id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-007375-hqmyund4	Tang, Yi-Wei	Host Single-Nucleotide Polymorphisms and Altered Responses to Inactivated Influenza Vaccine	2007-10-01		.txt	text/plain	2612	112	41	We analyzed the relationship between host gene polymorphisms and responses in recipients of inactivated influenza vaccine, who were classified into poor, normal, or adverse response groups. The frequency of the mannose-binding lectin-2 codon 54 allele was significantly different among the 3 types of responders, with a decreased odds ratio for the development of poor or adverse responses (P = .033). The present study explored the possibility that host gene polymorphisms influence inactivated influenza vaccineinduced immune responses by comparing the frequencies of 8 SNPs in the MBL-2 gene and in the TNF-a and IL-10 promoter regions among different groups. We found a significant difference in allele frequency in the MBL-2 codon 54 among the poor, normal, and adverse responders, suggesting that the allele polymorphism is independently associated with poor and adverse responses to influenza vaccination. These findings support the present data by suggesting that the Ϫ1082 allele polymorphism in the IL-10 promoter region may be associated with adverse responses induced by influenza vaccine.	./cache/cord-007375-hqmyund4.txt	./txt/cord-007375-hqmyund4.txt