id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-256769-flfycl7i	Stoermer, Kristina A.	Complement and Viral Pathogenesis	2011-03-01		.txt	text/plain	10339	493	39	Taken together, these studies and the findings that multiple components of the complement pathway are required for mice to survive ectromelia virus infection (discussed below), indicate that complement activation and viral evasion of the complement system are critical determinants of poxvirus pathogenesis. Mice deficient in C3, C4, or CR2 (which in mice encodes both CR1 and CR2) had significantly diminished IgG responses following Herpes Simplex virus-1 (HSV-1) infection, suggesting that activation of the classical pathway plays a key role in regulating the antibody response to HSV-1 infection (Da Costa et al., 1999) . Unlike VSV infection, the genetic absence of C3 or CR2 resulted in increased WNV-induced mortality, earlier WNV entry into the central nervous system, and greater viral loads of WNV in the brains of mice, suggesting complement-mediated regulation of B cell responses was critical to control WNV dissemination, replication, and disease (Mehlhop et al., 2005) .	./cache/cord-256769-flfycl7i.txt	./txt/cord-256769-flfycl7i.txt