Summary of your 'study carrel' ============================== This is a summary of your Distant Reader 'study carrel'. The Distant Reader harvested & cached your content into a collection/corpus. It then applied sets of natural language processing and text mining against the collection. The results of this process was reduced to a database file -- a 'study carrel'. The study carrel can then be queried, thus bringing light specific characteristics for your collection. These characteristics can help you summarize the collection as well as enumerate things you might want to investigate more closely. This report is a terse narrative report, and when processing is complete you will be linked to a more complete narrative report. Eric Lease Morgan Number of items in the collection; 'How big is my corpus?' ---------------------------------------------------------- 50 Average length of all items measured in words; "More or less, how big is each item?" ------------------------------------------------------------------------------------ 13586 Average readability score of all items (0 = difficult; 100 = easy) ------------------------------------------------------------------ 46 Top 50 statistically significant keywords; "What is my collection about?" ------------------------------------------------------------------------- 49 MBL 34 cell 33 TNF 33 IFN 33 CD8 31 IL-12 4 mannose 3 lectin 3 SARS 2 lactobacillus 2 complement 2 MBP 1 severe 1 response 1 protein 1 l10l 1 infection 1 figure 1 dna 1 bind 1 TBS 1 SLE 1 SIGN 1 MBL2 1 MBL-2 1 MASP2 1 MASP-2 1 MAC 1 L10H 1 IL-10 1 IBV 1 IAV 1 HIV 1 HCV 1 H9N2 1 H7N9 1 H1N1 1 Fig 1 DHF 1 CCL2 Top 50 lemmatized nouns; "What is discussed?" --------------------------------------------- 8899 cell 3005 response 2872 patient 2534 protein 1874 expression 1834 antibody 1807 level 1727 study 1687 cytokine 1597 infection 1519 result 1501 t 1436 virus 1426 p 1423 lectin 1309 antigen 1283 factor 1269 mouse 1259 role 1252 gene 1236 effect 1226 activation 1220 control 1207 molecule 1196 disease 1175 bacteria 1134 macrophage 1128 peptide 1126 complement 1119 production 1097 type 1088 activity 1076 blood 1058 receptor 1057 assay 970 % 964 tumour 899 system 899 cancer 822 concentration 816 h 816 datum 813 stimulation 811 group 783 pathway 773 time 770 protease 770 presence 767 strain 756 line Top 50 proper nouns; "What are the names of persons or places?" -------------------------------------------------------------- 3739 MBL 2108 IFN 1914 þ 1259 AE 1057 al 861 TNF 819 T 790 et 716 CD8 715 MS 701 IL-12 695 . 662 NK 644 CD4 637 HLA 591 DC 588 SP 566 g 564 ¼ 557 IL-10 548 A 505 C 436 a 432 mg 398 MHC 387 SARS 370 MBP 360 sera 349 S. 342 IgA 340 HC 339 GC 337 OspE 325 E. 321 MASP-2 297 OprI 297 IL-18 297 BCL-6 295 D 293 IgG 273 Mala 271 Stockholm 270 CLA 269 IgM 264 QBC 244 TLR 239 MT1 239 Der 238 Sassari 235 CD86 Top 50 personal pronouns nouns; "To whom are things referred?" ------------------------------------------------------------- 3898 we 548 it 357 i 213 they 182 them 102 iga1 36 us 35 one 35 itself 33 eph-4 1 Ϫ238 1 stlr2 1 he 1 cord-007375-hqmyund4 Top 50 lemmatized verbs; "What do things do?" --------------------------------------------- 21671 be 3853 have 2529 bind 2033 use 2003 induce 1785 increase 1320 find 1320 compare 1180 show 1015 associate 1008 demonstrate 896 investigate 893 suggest 822 involve 786 indicate 783 activate 664 detect 656 mediate 633 observe 591 develop 586 include 582 do 564 present 542 result 542 play 529 express 522 base 513 derive 511 perform 509 identify 480 relate 470 require 466 study 453 produce 432 examine 407 describe 404 measure 403 contain 391 lead 379 evaluate 378 determine 378 affect 376 analyse 371 decrease 362 provide 361 enhance 357 obtain 353 isolate 348 select 345 inhibit Top 50 lemmatized adjectives and adverbs; "How are things described?" --------------------------------------------------------------------- 1980 not 1889 high 1787 human 1495 immune 1285 low 1227 specific 1166 also 904 - 869 inflammatory 838 well 805 different 801 healthy 759 however 729 other 637 such 626 clinical 621 significantly 595 more 571 only 543 thus 540 dendritic 537 as 526 first 522 important 515 complement 486 recombinant 467 normal 450 anti 446 major 443 innate 438 further 429 recently 412 dependent 396 like 394 negative 392 antiviral 388 viral 386 significant 376 present 375 oral 368 peripheral 366 cellular 359 furthermore 353 bacterial 347 here 346 therefore 332 strong 324 novel 318 acute 313 various Top 50 lemmatized superlative adjectives; "How are things described to the extreme?" ------------------------------------------------------------------------- 48 least 45 most 36 great 5 high 5 good 4 low 3 Most 2 early 1 large 1 infantÕs 1 -t Top 50 lemmatized superlative adverbs; "How do things do to the extreme?" ------------------------------------------------------------------------ 168 most 33 well 7 least 1 lowest 1 highest Top 50 Internet domains; "What Webbed places are alluded to in this corpus?" ---------------------------------------------------------------------------- 2 www.ncbi.nlm.nih.gov 2 www.biomedcentral.com 2 dx.doi.org 1 www5.invitrogen.com 1 wbiomed.curtin.edu.au 1 en Top 50 URLs; "What is hyperlinked from this corpus?" ---------------------------------------------------- 1 http://www5.invitrogen.com/custom-genomic-products/tools/ 1 http://www.ncbi.nlm.nih.gov/SNP/ 1 http://www.ncbi.nlm.nih.gov/ 1 http://www.biomedcentral.com/content/supplementary/1471-2334-9-51-S1.doc] 1 http://www.biomedcentral.com/1471-2334/9/51/prepub 1 http://wbiomed.curtin.edu.au/ 1 http://en 1 http://dx.doi.org/10.1016/j.jinf.2015.03.006 1 http://dx.doi.org/10.1016/j.bbrc.2015 Top 50 email addresses; "Who are you gonna call?" ------------------------------------------------- 33 tgartner@vub.ac.be 33 stasa@hol.gr 33 rnsr@studmed.au.dk 33 michael.siassi@rzmail.uni-erlangen.de 33 judit.wefer@cmm.ki.se Top 50 positive assertions; "What sentences are in the shape of noun-verb-noun?" ------------------------------------------------------------------------------- 34 ae is not 34 antibodies are efficient 34 antibodies were present 34 bacteria induced inflammatory 34 bacteria was almost 34 bacteria was not 34 bacteria were intact 34 cells have long 34 cells have not 34 cells was severely 34 disease had significantly 34 genes were significantly 34 infection are surprisingly 34 levels were higher 34 proteins using mutagenesis 34 studies involving skin 34 virus was effectively 33 activation have so 33 antibodies was higher 33 cell mediated disease 33 cells are cells 33 cells express icosl 33 cells showed only 33 cells was significantly 33 expression did not 33 expression is similar 33 levels are predictive 33 levels were predictive 33 levels were subsequently 33 patients expressed significantly 33 patients had significant 33 response was further 33 response was not 33 responses were about 33 study involved longitudinal 10 mbl is able 7 mbl has also 6 mice are susceptible 5 mbl does not 4 lectin increases susceptibility 4 levels were not 4 mbl is also 3 antigen presenting cells 3 mbl was not 3 viruses are resistant 2 activation is harmful 2 cell mediated cytotoxicity 2 cells expressing viral 2 cells is necessary 2 cells were significantly Top 50 negative assertions; "What sentences are in the shape of noun-verb-no|not-noun?" --------------------------------------------------------------------------------------- 34 ae is not fully 34 proteins showed no difference 33 mbl showed no correlation 33 response was not compromised 3 levels were not different 2 cells showed no difference 1 activation does not only 1 activation is no greater 1 controls were not significantly 1 infection was not different 1 infections was not apparent 1 lectin is not only 1 levels have no clinical 1 mbl are not biologically 1 mbl does not opsonise 1 mbl plays no role 1 patients were not significant 1 results suggested no association 1 study demonstrated no association 1 study found no link 1 study observed no significant 1 virus is not well A rudimentary bibliography -------------------------- id = cord-023403-jzdrvfvr author = Ahlfors, E. title = Proliferation of Cells in the Oral Mucosa, the Ear Skin and the Regional Lymph Nodes in Mice Sensitized and Elicited with a Hapten date = 2008-06-28 keywords = CD8; IFN; IL-12; MBL; TNF; cell summary = We demonstrate that Cw6 þ psoriasis patients had significant CD8 þ T-cell IFN-g responses to peptides from K17 and M6 protein selected on the basis of sequence homology and predicted HLA-Cw*0602 binding. The uptake of MBP by B cells and the presentation of MBP-derive peptides to T helper (Th) cells by B cells may be promoted by the formation of complement (C) activating immune complexes (ICs) between MBP and natural autoantibodies in healthy individuals and disease-associated anti-MBP antibodies in MS patients, respectively. While MBP did not induce measurable proliferation of B cells nor CD4 þ T cells, we observed the production of TNF-a, IFN-g and IL-10 by PBMC in response to incubation with MBP in the presence of sera from healthy controls as well as sera from MS patients. In conclusion, the results of this study suggest an involvement of the ASMase in the activation, expansion or maturation of virus-specific CD8 þ T cells during the acute infection of mice with the LCM virus. doi = 10.1111/j.0300-9475.2004.01423ac.x id = cord-292581-6ipzvryb author = Alagarasu, Kalichamy title = Elevated levels of vitamin D and deficiency of mannose binding lectin in dengue hemorrhagic fever date = 2012-05-04 keywords = DHF; MBL summary = BACKGROUND: Altered plasma concentrations of vitamin D and mannose binding lectin (MBL), components of innate immunity, have been shown to be associated with the pathogenesis of viral infections. The objective of the present study was to find out whether plasma concentrations of MBL and vitamin D are different in patients with dengue fever (DF) and dengue hemorrhagic fever (DHF). Therefore, we investigated the levels of plasma vitamin D and MBL in dengue infected patients in the context of disease severity and immune status. When the patients were grouped based on immune status and disease severity, secondary DHF cases had significantly higher concentrations of vitamin D as compared to secondary DF cases (P < 0.050). Analysis of circulating concentrations of MBL in dengue cases and healthy controls revealed no significant difference between the two groups suggesting that the MBL mediated pathway of complement activation might be inhibited or may not be induced during DENV infection. doi = 10.1186/1743-422x-9-86 id = cord-023375-x4p187u7 author = Alitalo, A. title = Lysine‐Dependent Binding of OspE to the C‐terminus of Factor H Mediates Complement Resistance in Borrelia burgdorferi date = 2008-06-28 keywords = CD8; IFN; IL-12; MBL; TNF; cell summary = We demonstrate that Cw6 þ psoriasis patients had significant CD8 þ T-cell IFN-g responses to peptides from K17 and M6 protein selected on the basis of sequence homology and predicted HLA-Cw*0602 binding. The uptake of MBP by B cells and the presentation of MBP-derive peptides to T helper (Th) cells by B cells may be promoted by the formation of complement (C) activating immune complexes (ICs) between MBP and natural autoantibodies in healthy individuals and disease-associated anti-MBP antibodies in MS patients, respectively. While MBP did not induce measurable proliferation of B cells nor CD4 þ T cells, we observed the production of TNF-a, IFN-g and IL-10 by PBMC in response to incubation with MBP in the presence of sera from healthy controls as well as sera from MS patients. In conclusion, the results of this study suggest an involvement of the ASMase in the activation, expansion or maturation of virus-specific CD8 þ T cells during the acute infection of mice with the LCM virus. doi = 10.1111/j.0300-9475.2004.01423aj.x id = cord-023411-iszb5qlk author = Astrinidou‐Vakaloudi, A. title = Presence of Helicobacter pylori Antibodies in Haemodialysis Patients date = 2008-06-28 keywords = CD8; IFN; IL-12; MBL; TNF; cell summary = We demonstrate that Cw6 þ psoriasis patients had significant CD8 þ T-cell IFN-g responses to peptides from K17 and M6 protein selected on the basis of sequence homology and predicted HLA-Cw*0602 binding. The uptake of MBP by B cells and the presentation of MBP-derive peptides to T helper (Th) cells by B cells may be promoted by the formation of complement (C) activating immune complexes (ICs) between MBP and natural autoantibodies in healthy individuals and disease-associated anti-MBP antibodies in MS patients, respectively. While MBP did not induce measurable proliferation of B cells nor CD4 þ T cells, we observed the production of TNF-a, IFN-g and IL-10 by PBMC in response to incubation with MBP in the presence of sera from healthy controls as well as sera from MS patients. In conclusion, the results of this study suggest an involvement of the ASMase in the activation, expansion or maturation of virus-specific CD8 þ T cells during the acute infection of mice with the LCM virus. doi = 10.1111/j.0300-9475.2004.01423p.x id = cord-023390-5hcgdlmt author = Bhuvanath, S. title = Inflammatory Cytokine Modulation of Cancer Cell Proliferation date = 2008-06-28 keywords = CD8; IFN; IL-12; MBL; TNF; cell summary = We demonstrate that Cw6 þ psoriasis patients had significant CD8 þ T-cell IFN-g responses to peptides from K17 and M6 protein selected on the basis of sequence homology and predicted HLA-Cw*0602 binding. The uptake of MBP by B cells and the presentation of MBP-derive peptides to T helper (Th) cells by B cells may be promoted by the formation of complement (C) activating immune complexes (ICs) between MBP and natural autoantibodies in healthy individuals and disease-associated anti-MBP antibodies in MS patients, respectively. While MBP did not induce measurable proliferation of B cells nor CD4 þ T cells, we observed the production of TNF-a, IFN-g and IL-10 by PBMC in response to incubation with MBP in the presence of sera from healthy controls as well as sera from MS patients. In conclusion, the results of this study suggest an involvement of the ASMase in the activation, expansion or maturation of virus-specific CD8 þ T cells during the acute infection of mice with the LCM virus. doi = 10.1111/j.0300-9475.2004.01423bi.x id = cord-023414-xxw5kptr author = Chistensen, H. R. title = Characterization of a Large Panel of Lactic Acid Bacteria Derived from the Human Gut for their Capacity to Polarize Dendritic Cell date = 2008-06-28 keywords = CD8; IFN; MBL; TNF; cell; lactobacillus summary = We demonstrate that Cw6 þ psoriasis patients had significant CD8 þ T-cell IFN-g responses to peptides from K17 and M6 protein selected on the basis of sequence homology and predicted HLA-Cw*0602 binding. The uptake of MBP by B cells and the presentation of MBP-derive peptides to T helper (Th) cells by B cells may be promoted by the formation of complement (C) activating immune complexes (ICs) between MBP and natural autoantibodies in healthy individuals and disease-associated anti-MBP antibodies in MS patients, respectively. While MBP did not induce measurable proliferation of B cells nor CD4 þ T cells, we observed the production of TNF-a, IFN-g and IL-10 by PBMC in response to incubation with MBP in the presence of sera from healthy controls as well as sera from MS patients. In conclusion, the results of this study suggest an involvement of the ASMase in the activation, expansion or maturation of virus-specific CD8 þ T cells during the acute infection of mice with the LCM virus. doi = 10.1111/j.0300-9475.2004.01423ap.x id = cord-324840-ug5a9wx6 author = De Pascale, Gennaro title = The Role of Mannose-Binding Lectin in Severe Sepsis and Septic Shock date = 2013-10-02 keywords = MBL; lectin; mannose; severe summary = In a cohort of critically ill pediatric patients, Fidler and coworkers observed that MBL levels less than 1000 ng/mL, consistent with MBL-2 gene exon 1 polymorphisms, significantly increased the risk of developing systemic inflammatory response syndrome (SIRS) and progression to severe sepsis/septic shock [32] . The association between the deficiency of this protein and worse outcome during severe systemic infections (i.e., evolution to refractory septic shock) may be also related to the significant interaction between complement activation, inflammatory cytokines'' "storm", and coagulation cascade. Hence MBL, due to its pivotal role in the crosstalking among complement activation, coagulation, and systemic inflammation, may represent a key point for the understanding of the development of systemic severe infections, as interestingly investigated in animal models and clinical studies involving patients with severe sepsis/septic shock. doi = 10.1155/2013/625803 id = cord-278644-u4swxsjj author = Degn, Søren E. title = MAp19, the alternative splice product of the MASP2 gene date = 2011-10-28 keywords = Fig; MASP-2; MBL; TBS summary = Strips of a Western blot containing purified MBL/MASP complexes from human plasma were developed using hybridoma supernatants as primary antibodies. Strips were incubated with hybridoma supernatants diluted 1/10 in primary buffer (TBS/Tw, 1 mM EDTA, with 1 mg HSA and 100 μg normal human IgG (hIgG) added per ml), or with the parental rat serum 1/500. The wells were then blocked with HSA, 1 mg/ml TBS, washed thrice with TBS/Tw, and incubated with serum samples diluted 20-fold in MAp19 buffer (TBS/Tw, 1 M total NaCl, 10 mM EDTA, containing 100 μg ΔhIgG (heat-aggregated hIgG); Beriglobin, from ZLB Behring GmbH, incubated 30 min at 63°C and centrifuged 10 min at 3,000 g to remove large aggregates) per ml, and 100 μg normal rat IgG (Lampire) per ml) o.n. at RT. The specificity of the anti-MAp19 antibodies was validated by performing Western blotting with purified MBL/MASP complex (Fig. 1C) . doi = 10.1016/j.jim.2011.08.006 id = cord-306111-wn1gxhk9 author = Dommett, R. M. title = Mannose‐binding lectin in innate immunity: past, present and future date = 2006-09-01 keywords = HIV; MBL; infection; lectin; mannose; protein summary = Third MBL mutation in codon 52 (variant D) described (52) 1995 Polymorphisms found in promoter region of MBL gene (55) 1997 Second MASP found to activate complement (20) MBL mutations are an important risk factor for infections in children (132) 1998 Reconstitution of opsonizing activity by infusion of purified MBL into MBL-deficient humans (112) 1999 Truncated form of MASP-2 -MAp19 (21) 2000 Complement-activating complex of ficolins and MASP (133) MBL shown to bind to clinically relevant organisms (15) Structural aspects of MBL doi = 10.1111/j.1399-0039.2006.00649.x id = cord-023441-q83y12sk author = Draborg, H. title = Recominant Expression and Immunological Characterization of House Dust Mite Allergen Der P 1 date = 2008-06-28 keywords = CD8; IFN; IL-12; MBL; TNF; cell summary = We demonstrate that Cw6 þ psoriasis patients had significant CD8 þ T-cell IFN-g responses to peptides from K17 and M6 protein selected on the basis of sequence homology and predicted HLA-Cw*0602 binding. The uptake of MBP by B cells and the presentation of MBP-derive peptides to T helper (Th) cells by B cells may be promoted by the formation of complement (C) activating immune complexes (ICs) between MBP and natural autoantibodies in healthy individuals and disease-associated anti-MBP antibodies in MS patients, respectively. While MBP did not induce measurable proliferation of B cells nor CD4 þ T cells, we observed the production of TNF-a, IFN-g and IL-10 by PBMC in response to incubation with MBP in the presence of sera from healthy controls as well as sera from MS patients. In conclusion, the results of this study suggest an involvement of the ASMase in the activation, expansion or maturation of virus-specific CD8 þ T cells during the acute infection of mice with the LCM virus. doi = 10.1111/j.0300-9475.2004.01423ag.x id = cord-266739-oay8gbit author = Eisen, Damon P. title = No association between mannose-binding lectin deficiency and H1N1 2009 infection observed during the first season of this novel pandemic influenza virus date = 2011-11-30 keywords = H1N1; MBL summary = title: No association between mannose-binding lectin deficiency and H1N1 2009 infection observed during the first season of this novel pandemic influenza virus Therefore, we studied whether MBL deficiency played a role in infection with the novel H1N1 2009 influenza strain in exposed health care workers. This is countered, however, by the in vitro evidence of MBL''s inhibition of influenza virus [3, 18] , recent evidence of MBL''s role in the development of humoral immunity to influenza [19] , and clinical association studies that demonstrate that MBL deficiency predisposes not only to respiratory tract infection in general, but also to respiratory tract infections with viral pathogens like severe acute respiratory syndrome in particular [7] . Although we have not demonstrated a clinical association between MBL deficiency and predisposition to the novel H1N1 2009 influenza strain, this may be because of the absence of exposed MBL-binding sites on this specific virus. doi = 10.1016/j.humimm.2011.08.014 id = cord-310110-haukpwtf author = Guo, Jinlei title = Limited effect of recombinant human mannose-binding lectin on the infection of novel influenza A (H7N9) virus in vitro date = 2015-02-27 keywords = H7N9; MBL summary = title: Limited effect of recombinant human mannose-binding lectin on the infection of novel influenza A (H7N9) virus in vitro Our findings suggest that MBL, the host innate molecule, has differential interference effects with human and avian influenza virus and limited antiviral effect against H7N9 virus. Different concentrations of rhMBL were diluted in HBSS containing Ca 2þ and mixed with influenza virus in a total volume of 100 mL and preincubated at 37 C for 1 h, and then transferred to wells precoated with fetuin (Sigma, USA) and incubated at 37 C for 4 h, After washing, 100 mL of HRP-labeled peanut lectin (3 mg/mL) was added and after 1 h at room temperature, the wells were washed and o-phenylenediamine dihydrochloride in citrate buffer was added, reaction was stopped by 2 M H 2 SO 4 , and the OD at 492 nm was measured. Therefore, the strong MBL-H7N9 virus interaction whereas limited effects on viral HA-receptor binding or NA-mediated releasing, might amplify immune dysfunctions in vivo and confer clinical severity of H7N9 infection via activating complement pathway and further investigates are needed. Human mannan-binding lectin inhibits the infection of influenza A virus without complement doi = 10.1016/j.bbrc.2015.01.070 id = cord-017438-x12d2ewc author = Gupta, Anita title = MBL Deficiency as Risk of Infection and Autoimmunity date = 2012-03-20 keywords = MBL; MBL2; MBP; SLE; lectin; mannose summary = The distribution of MBL gene polymorphisms was significantly different between patients with SARS and normal subjects, with a higher frequency of haplotypes associated with low or deficient serum levels of MBL in patients with SARS. Whether variant alleles of the MBL gene causing low serum concentrations of MBL are associated with increased susceptibility to RA and erosive outcome in an inception cohort of patients with early polyarthritis was studied by Jacobsen et al. SLE patients were associated with a reduced functional activity of the MBL pathway of complement, in relation to expression of MBL variant alleles, increased levels of autoantibodies against cardiolipin and C1q, but not against MBL. Polymorphisms of both codon 54 allele and promoter variants of the mannose MBL gene in patients with primary Sjogren''s syndrome (SS) was suggested as one of the genetic factors that determines susceptibility to SS (Wang et al. Association of mannose-binding lectin gene variation with disease severity and infections in a population-based cohort of systemic lupus erythematosus patients doi = 10.1007/978-3-7091-1065-2_42 id = cord-023392-axd0901z author = Hansen, T. K. title = Association between Mannose‐Binding Lectin and Vascular Complications in Type 1 Diabetes date = 2008-06-28 keywords = CD8; IFN; IL-12; MBL; TNF; cell summary = We demonstrate that Cw6 þ psoriasis patients had significant CD8 þ T-cell IFN-g responses to peptides from K17 and M6 protein selected on the basis of sequence homology and predicted HLA-Cw*0602 binding. The uptake of MBP by B cells and the presentation of MBP-derive peptides to T helper (Th) cells by B cells may be promoted by the formation of complement (C) activating immune complexes (ICs) between MBP and natural autoantibodies in healthy individuals and disease-associated anti-MBP antibodies in MS patients, respectively. While MBP did not induce measurable proliferation of B cells nor CD4 þ T cells, we observed the production of TNF-a, IFN-g and IL-10 by PBMC in response to incubation with MBP in the presence of sera from healthy controls as well as sera from MS patients. In conclusion, the results of this study suggest an involvement of the ASMase in the activation, expansion or maturation of virus-specific CD8 þ T cells during the acute infection of mice with the LCM virus. doi = 10.1111/j.0300-9475.2004.01423i.x id = cord-023439-r04y1j22 author = Hedegaard, C. J. title = The Role of Immune Complexes Consisting of Myelin Basic Protein (MBP), Anti‐MBP Antibodies and Complement in Promoting CD4(+) T‐cell Responses to MBP in Health and Multiple Sclerosis date = 2008-06-28 keywords = CD8; IFN; MBL; MBP; TNF; cell summary = We demonstrate that Cw6 þ psoriasis patients had significant CD8 þ T-cell IFN-g responses to peptides from K17 and M6 protein selected on the basis of sequence homology and predicted HLA-Cw*0602 binding. The uptake of MBP by B cells and the presentation of MBP-derive peptides to T helper (Th) cells by B cells may be promoted by the formation of complement (C) activating immune complexes (ICs) between MBP and natural autoantibodies in healthy individuals and disease-associated anti-MBP antibodies in MS patients, respectively. While MBP did not induce measurable proliferation of B cells nor CD4 þ T cells, we observed the production of TNF-a, IFN-g and IL-10 by PBMC in response to incubation with MBP in the presence of sera from healthy controls as well as sera from MS patients. doi = 10.1111/j.0300-9475.2004.01423k.x id = cord-023388-btbf6wkg author = Hoffmann, H. J. title = Decrease in Fine T‐cell Subset ratio MT2/MT1 During Steroid Reduction of Asthmatic Patients date = 2008-06-28 keywords = CD8; IFN; IL-12; MBL; TNF; cell summary = We demonstrate that Cw6 þ psoriasis patients had significant CD8 þ T-cell IFN-g responses to peptides from K17 and M6 protein selected on the basis of sequence homology and predicted HLA-Cw*0602 binding. The uptake of MBP by B cells and the presentation of MBP-derive peptides to T helper (Th) cells by B cells may be promoted by the formation of complement (C) activating immune complexes (ICs) between MBP and natural autoantibodies in healthy individuals and disease-associated anti-MBP antibodies in MS patients, respectively. While MBP did not induce measurable proliferation of B cells nor CD4 þ T cells, we observed the production of TNF-a, IFN-g and IL-10 by PBMC in response to incubation with MBP in the presence of sera from healthy controls as well as sera from MS patients. In conclusion, the results of this study suggest an involvement of the ASMase in the activation, expansion or maturation of virus-specific CD8 þ T cells during the acute infection of mice with the LCM virus. doi = 10.1111/j.0300-9475.2004.01423ah.x id = cord-023407-s85g7g0x author = Huang, Y.‐M. title = Anti‐Inflammatory Liver X Receptors and Related Molecules in Multiple Sclerosis Patients from Sardinia and Sweden date = 2008-06-28 keywords = CD8; IFN; IL-12; MBL; TNF; cell summary = We demonstrate that Cw6 þ psoriasis patients had significant CD8 þ T-cell IFN-g responses to peptides from K17 and M6 protein selected on the basis of sequence homology and predicted HLA-Cw*0602 binding. The uptake of MBP by B cells and the presentation of MBP-derive peptides to T helper (Th) cells by B cells may be promoted by the formation of complement (C) activating immune complexes (ICs) between MBP and natural autoantibodies in healthy individuals and disease-associated anti-MBP antibodies in MS patients, respectively. While MBP did not induce measurable proliferation of B cells nor CD4 þ T cells, we observed the production of TNF-a, IFN-g and IL-10 by PBMC in response to incubation with MBP in the presence of sera from healthy controls as well as sera from MS patients. In conclusion, the results of this study suggest an involvement of the ASMase in the activation, expansion or maturation of virus-specific CD8 þ T cells during the acute infection of mice with the LCM virus. doi = 10.1111/j.0300-9475.2004.01423d.x id = cord-023387-tyeh14wz author = Hvas, C. L. title = Probiotic Bacteria Induce Regulatory Cytokine Production via Dendritic Cells date = 2008-06-28 keywords = CD8; IFN; IL-12; MBL; TNF; cell; lactobacillus summary = We demonstrate that Cw6 þ psoriasis patients had significant CD8 þ T-cell IFN-g responses to peptides from K17 and M6 protein selected on the basis of sequence homology and predicted HLA-Cw*0602 binding. The uptake of MBP by B cells and the presentation of MBP-derive peptides to T helper (Th) cells by B cells may be promoted by the formation of complement (C) activating immune complexes (ICs) between MBP and natural autoantibodies in healthy individuals and disease-associated anti-MBP antibodies in MS patients, respectively. While MBP did not induce measurable proliferation of B cells nor CD4 þ T cells, we observed the production of TNF-a, IFN-g and IL-10 by PBMC in response to incubation with MBP in the presence of sera from healthy controls as well as sera from MS patients. In conclusion, the results of this study suggest an involvement of the ASMase in the activation, expansion or maturation of virus-specific CD8 þ T cells during the acute infection of mice with the LCM virus. doi = 10.1111/j.0300-9475.2004.01423au.x id = cord-023394-ptfjxpo6 author = Isa, A. title = Mapping of the Ex Vivo Cellular Immune Response Against the Complete Human Parvovirus B19 Genome During Acute Infection date = 2008-06-28 keywords = CD8; IFN; IL-12; MBL; TNF; cell summary = We demonstrate that Cw6 þ psoriasis patients had significant CD8 þ T-cell IFN-g responses to peptides from K17 and M6 protein selected on the basis of sequence homology and predicted HLA-Cw*0602 binding. The uptake of MBP by B cells and the presentation of MBP-derive peptides to T helper (Th) cells by B cells may be promoted by the formation of complement (C) activating immune complexes (ICs) between MBP and natural autoantibodies in healthy individuals and disease-associated anti-MBP antibodies in MS patients, respectively. While MBP did not induce measurable proliferation of B cells nor CD4 þ T cells, we observed the production of TNF-a, IFN-g and IL-10 by PBMC in response to incubation with MBP in the presence of sera from healthy controls as well as sera from MS patients. In conclusion, the results of this study suggest an involvement of the ASMase in the activation, expansion or maturation of virus-specific CD8 þ T cells during the acute infection of mice with the LCM virus. doi = 10.1111/j.0300-9475.2004.01423n.x id = cord-022631-s4n24xij author = Jonsson, M. V. title = Germinal Centres in Primary Sjögren''s Syndrome Indicate a Certain Clinical Immunological Phenotype date = 2008-06-28 keywords = CD8; IFN; IL-12; MBL; TNF; cell summary = We demonstrate that Cw6 þ psoriasis patients had significant CD8 þ T-cell IFN-g responses to peptides from K17 and M6 protein selected on the basis of sequence homology and predicted HLA-Cw*0602 binding. The uptake of MBP by B cells and the presentation of MBP-derive peptides to T helper (Th) cells by B cells may be promoted by the formation of complement (C) activating immune complexes (ICs) between MBP and natural autoantibodies in healthy individuals and disease-associated anti-MBP antibodies in MS patients, respectively. While MBP did not induce measurable proliferation of B cells nor CD4 þ T cells, we observed the production of TNF-a, IFN-g and IL-10 by PBMC in response to incubation with MBP in the presence of sera from healthy controls as well as sera from MS patients. In conclusion, the results of this study suggest an involvement of the ASMase in the activation, expansion or maturation of virus-specific CD8 þ T cells during the acute infection of mice with the LCM virus. doi = 10.1111/j.0300-9475.2004.01423h.x id = cord-023415-hhvmsn5b author = Karlsson, H. title = Pattern of Cytokine Responses to Gram‐Positive and Gram‐Negative Commensal Bacteria is Profoundly Changed when Monocytes Differentiate into Dendritic Cells date = 2008-06-28 keywords = CD8; IFN; IL-12; MBL; TNF; cell summary = We demonstrate that Cw6 þ psoriasis patients had significant CD8 þ T-cell IFN-g responses to peptides from K17 and M6 protein selected on the basis of sequence homology and predicted HLA-Cw*0602 binding. The uptake of MBP by B cells and the presentation of MBP-derive peptides to T helper (Th) cells by B cells may be promoted by the formation of complement (C) activating immune complexes (ICs) between MBP and natural autoantibodies in healthy individuals and disease-associated anti-MBP antibodies in MS patients, respectively. While MBP did not induce measurable proliferation of B cells nor CD4 þ T cells, we observed the production of TNF-a, IFN-g and IL-10 by PBMC in response to incubation with MBP in the presence of sera from healthy controls as well as sera from MS patients. In conclusion, the results of this study suggest an involvement of the ASMase in the activation, expansion or maturation of virus-specific CD8 þ T cells during the acute infection of mice with the LCM virus. doi = 10.1111/j.0300-9475.2004.01423at.x id = cord-342176-tewfm8it author = Kjærup, Rikke M. title = Adjuvant effects of mannose-binding lectin ligands on the immune response to infectious bronchitis vaccine in chickens with high or low serum mannose-binding lectin concentrations date = 2013-11-08 keywords = IBV; L10H; MBL; l10l summary = title: Adjuvant effects of mannose-binding lectin ligands on the immune response to infectious bronchitis vaccine in chickens with high or low serum mannose-binding lectin concentrations Chickens from two inbred lines (L10H and L10L) selected for high or low MBL serum concentrations, respectively, were vaccinated against IBV with or without the addition of the MBL ligands mannan, chitosan and fructooligosaccharide (FOS). Studies using these chicken sublines as well as outbred chickens have shown an inverse relationship between the MBL concentrations and the pathogen-specific antibody response (Juul-Madsen et al. However, MBL has an influence as the difference was more pronounced for the L10H chickens than L10L chickens for both the IBV-specific IgG antibody titres and the numbers of CD4−CD8␣+ and CD4−CD8␣− cells. Mannan-binding lectin (MBL) serum concentration in relation to propagation of infectious bronchitis virus (IBV) in chickens Crosstalk between innate and adaptive immune responses to infectious bronchitis virus after vaccination and challenge of chickens varying in serum mannose-binding lectin concentrations doi = 10.1016/j.imbio.2013.10.013 id = cord-023410-eblcf902 author = Kollgaard, T. M. title = Clonally Expanded CD8(+) T cells in Allogeneic Bone Marrow Transplantation date = 2008-06-28 keywords = CD8; IFN; IL-12; MBL; TNF; cell summary = We demonstrate that Cw6 þ psoriasis patients had significant CD8 þ T-cell IFN-g responses to peptides from K17 and M6 protein selected on the basis of sequence homology and predicted HLA-Cw*0602 binding. The uptake of MBP by B cells and the presentation of MBP-derive peptides to T helper (Th) cells by B cells may be promoted by the formation of complement (C) activating immune complexes (ICs) between MBP and natural autoantibodies in healthy individuals and disease-associated anti-MBP antibodies in MS patients, respectively. While MBP did not induce measurable proliferation of B cells nor CD4 þ T cells, we observed the production of TNF-a, IFN-g and IL-10 by PBMC in response to incubation with MBP in the presence of sera from healthy controls as well as sera from MS patients. In conclusion, the results of this study suggest an involvement of the ASMase in the activation, expansion or maturation of virus-specific CD8 þ T cells during the acute infection of mice with the LCM virus. doi = 10.1111/j.0300-9475.2004.01423bm.x id = cord-023393-8nye3nc8 author = Krarup, A. title = Mannan‐Binding Lectin, L‐Ficolin and H‐Ficolin Selectively Binds to Different Bacteria date = 2008-06-28 keywords = CD8; IFN; IL-12; MBL; TNF; cell summary = We demonstrate that Cw6 þ psoriasis patients had significant CD8 þ T-cell IFN-g responses to peptides from K17 and M6 protein selected on the basis of sequence homology and predicted HLA-Cw*0602 binding. The uptake of MBP by B cells and the presentation of MBP-derive peptides to T helper (Th) cells by B cells may be promoted by the formation of complement (C) activating immune complexes (ICs) between MBP and natural autoantibodies in healthy individuals and disease-associated anti-MBP antibodies in MS patients, respectively. While MBP did not induce measurable proliferation of B cells nor CD4 þ T cells, we observed the production of TNF-a, IFN-g and IL-10 by PBMC in response to incubation with MBP in the presence of sera from healthy controls as well as sera from MS patients. In conclusion, the results of this study suggest an involvement of the ASMase in the activation, expansion or maturation of virus-specific CD8 þ T cells during the acute infection of mice with the LCM virus. doi = 10.1111/j.0300-9475.2004.01423al.x id = cord-023438-g0k0vvdc author = Krog, J. title = The Effects of Hyperbaric Exposure on Human Peripheral Blood Mononuclear Cells, with Special Emphasis on Natural Killer Cell Cytotoxicity and Subsets date = 2008-06-28 keywords = CD8; IFN; IL-12; MBL; TNF; cell summary = We demonstrate that Cw6 þ psoriasis patients had significant CD8 þ T-cell IFN-g responses to peptides from K17 and M6 protein selected on the basis of sequence homology and predicted HLA-Cw*0602 binding. The uptake of MBP by B cells and the presentation of MBP-derive peptides to T helper (Th) cells by B cells may be promoted by the formation of complement (C) activating immune complexes (ICs) between MBP and natural autoantibodies in healthy individuals and disease-associated anti-MBP antibodies in MS patients, respectively. While MBP did not induce measurable proliferation of B cells nor CD4 þ T cells, we observed the production of TNF-a, IFN-g and IL-10 by PBMC in response to incubation with MBP in the presence of sera from healthy controls as well as sera from MS patients. In conclusion, the results of this study suggest an involvement of the ASMase in the activation, expansion or maturation of virus-specific CD8 þ T cells during the acute infection of mice with the LCM virus. doi = 10.1111/j.0300-9475.2004.01423aa.x id = cord-023445-c4tqioz1 author = Lauridsen, C. title = Supplementation of Vitamin C to Weaner Diets Increases IgM Concentration and Improves the Biological Activity of Vitamin E in Alveolar Macrophages date = 2008-06-28 keywords = CD8; IFN; IL-12; MBL; TNF; cell summary = We demonstrate that Cw6 þ psoriasis patients had significant CD8 þ T-cell IFN-g responses to peptides from K17 and M6 protein selected on the basis of sequence homology and predicted HLA-Cw*0602 binding. The uptake of MBP by B cells and the presentation of MBP-derive peptides to T helper (Th) cells by B cells may be promoted by the formation of complement (C) activating immune complexes (ICs) between MBP and natural autoantibodies in healthy individuals and disease-associated anti-MBP antibodies in MS patients, respectively. While MBP did not induce measurable proliferation of B cells nor CD4 þ T cells, we observed the production of TNF-a, IFN-g and IL-10 by PBMC in response to incubation with MBP in the presence of sera from healthy controls as well as sera from MS patients. In conclusion, the results of this study suggest an involvement of the ASMase in the activation, expansion or maturation of virus-specific CD8 þ T cells during the acute infection of mice with the LCM virus. doi = 10.1111/j.0300-9475.2004.01423u.x id = cord-000524-5y9kfyk9 author = Ling, Man To title = Mannose-Binding Lectin Contributes to Deleterious Inflammatory Response in Pandemic H1N1 and Avian H9N2 Infection date = 2011-11-11 keywords = H9N2; MBL summary = Furthermore, MBL WT mice had enhanced production of proinflammatory cytokines and chemokines compared with MBL KO mice, suggesting that MBL could upregulate inflammatory responses that may potentially worsen pdmH1N1 and H9N2/G1 virus infections. In the present study, we investigated whether MBL could display any in vitro or in vivo antiviral function toward pdmH1N1 and H9N2/G1 viruses, as well as whether it could modulate the inflammatory response upon infection by these two strains of influenza virus. As shown in Figures 4 and 5 , upon pdmH1N1 and H9N2/G1 virus infection, inflammatory response assayed by cytokines and chemokines production was triggered in both MBL WT and MBL KO mice. Consistent with our cytokine and chemokine data, the pulmonary histological analysis suggested that the MBL WT mice had a more severe inflammatory response upon pdmH1N1 and H9N2/G1 virus infection. doi = 10.1093/infdis/jir691 id = cord-268902-npug5c8p author = Liu, Yang title = The Roles of Direct Recognition by Animal Lectins in Antiviral Immunity and Viral Pathogenesis date = 2015-01-29 keywords = MBL; SIGN; figure summary = In agreement with the findings in mosquitoes, a recent study has identified a C-type lectin in the shrimp Marsupenaeus japonicus that interacts with an envelope protein of White spot syndrome virus (WSSV) and consequently associates with a cell-surface calreticulin, which serves as a membrane receptor that facilitates viral entry in a cholesterol-dependent manner [128] . The interaction between lectins and viral glycoproteins may lead to the three following consequences: (1) lectins, such as MBL and SPs, function as pattern recognition molecules that bind a repertoire of viruses and activate antiviral immune responses; (2) lectins are employed as attachment factors that recruit viral particles to the cell membrane to enhance viral entry, e.g., some mammalian lectins (DC-SIGN, L-SIGN, MR and MPRs) or their homologs in arthropods (mosGCTLs); and (3) some intracellular lectins, such as calnexin and ERGIC-53, function as susceptibility factors associated with virus-encoded proteins to facilitate viral replication or assembly (please refer to Figures 1 and 4) . doi = 10.3390/molecules20022272 id = cord-023373-6wh1kb3p author = Melchjorsen, J. title = Differential Requirements for Toll‐Like Receptor Signalling for Induction of Chemokine Expression by Herpes Simplex Virus and Sendai Virus date = 2008-06-28 keywords = CD8; IFN; IL-12; MBL; TNF; cell summary = We demonstrate that Cw6 þ psoriasis patients had significant CD8 þ T-cell IFN-g responses to peptides from K17 and M6 protein selected on the basis of sequence homology and predicted HLA-Cw*0602 binding. The uptake of MBP by B cells and the presentation of MBP-derive peptides to T helper (Th) cells by B cells may be promoted by the formation of complement (C) activating immune complexes (ICs) between MBP and natural autoantibodies in healthy individuals and disease-associated anti-MBP antibodies in MS patients, respectively. While MBP did not induce measurable proliferation of B cells nor CD4 þ T cells, we observed the production of TNF-a, IFN-g and IL-10 by PBMC in response to incubation with MBP in the presence of sera from healthy controls as well as sera from MS patients. In conclusion, the results of this study suggest an involvement of the ASMase in the activation, expansion or maturation of virus-specific CD8 þ T cells during the acute infection of mice with the LCM virus. doi = 10.1111/j.0300-9475.2004.01423r.x id = cord-304626-ffao7vka author = Mellors, Jack title = Viral Evasion of the Complement System and Its Importance for Vaccines and Therapeutics date = 2020-07-09 keywords = MAC; MBL; SARS; cell; complement summary = A better understanding of this virus-host interplay and its contribution to pathogenesis has previously led to: the identification of genetic factors which influence viral infection and disease outcome, the development of novel antivirals, and the production of safer, more effective vaccines. Infected host cells which present viral antigens on the cell surface membrane can activate the classical pathway, as the antigens bind IgM/IgG to induce complement dependent cytotoxicity (CDC). Non-neutralizing antibodies can still bind the viral target with the potential to cross-link with Fc receptors, or activate complement and interact with complement receptors, to enhance viral infection of host cells (241) . Use of the non-neutralizing influenza virus M2 extracellular vaccine in mice required functional C3 to confer protection and induce effective humoral and cell-mediated immune responses (245) . doi = 10.3389/fimmu.2020.01450 id = cord-322933-5xnxjqm5 author = Murugaiah, Valarmathy title = Collectins: Innate Immune Pattern Recognition Molecules date = 2020-03-10 keywords = IAV; MBL; bind; mannose summary = The following nine collectins have been identified to date: mannan-binding lectin (MBL), three bovine serum collectins, conglutinin, CL-43 and CL-46, lung surfactant proteins SP-A and SP-D, and more recently discovered collectins including, collectin kidney 1 (CL-K1, also called CL-11), collectin liver 1 (CL-L1, also called CL-10) and collectin placenta 1 (CL-P1 also called CL-12). Thus, the interaction between SIRP-α and SHP-1 negatively regulates P38-MAP kinase signalling, and stimulates NF-κB activity, and cells become resistant to TNF-mediated effects, such as apoptosis (1) C1qRp (CD93) (C1q receptor associated with phagocytosis stimulated by C1q, MBL or SP-A): but this has subsequently been shown not to bind any of these ligands. Pulmonary surfactant protein A mediates enhanced phagocytosis of Mycobacterium tuberculosis by a direct interaction with human macrophages Role of mannose-binding lectin in the innate defense against Candida albicans: enhancement of complement activation, but lack of opsonic function, in phagocytosis by human dendritic cells doi = 10.1007/978-981-15-1580-4_4 id = cord-023430-5zuewjv2 author = Nilkaeo, A. title = Interleukin‐18 Inhibition of Oral Carcinoma Cell Proliferation date = 2008-06-28 keywords = CD8; IFN; IL-12; MBL; TNF; cell summary = We demonstrate that Cw6 þ psoriasis patients had significant CD8 þ T-cell IFN-g responses to peptides from K17 and M6 protein selected on the basis of sequence homology and predicted HLA-Cw*0602 binding. The uptake of MBP by B cells and the presentation of MBP-derive peptides to T helper (Th) cells by B cells may be promoted by the formation of complement (C) activating immune complexes (ICs) between MBP and natural autoantibodies in healthy individuals and disease-associated anti-MBP antibodies in MS patients, respectively. While MBP did not induce measurable proliferation of B cells nor CD4 þ T cells, we observed the production of TNF-a, IFN-g and IL-10 by PBMC in response to incubation with MBP in the presence of sera from healthy controls as well as sera from MS patients. In conclusion, the results of this study suggest an involvement of the ASMase in the activation, expansion or maturation of virus-specific CD8 þ T cells during the acute infection of mice with the LCM virus. doi = 10.1111/j.0300-9475.2004.01423bg.x id = cord-023372-ft8cp9op author = Rahman, Q. K. title = The Immunomodulatory Effect of Heat Shock Protein 70: Immunization with a DNA Construct Based on the Malarial Antigen Fused with a Fragment of HSP 70 Primes for a Th‐1 Type of Response date = 2008-06-28 keywords = CD8; IFN; IL-12; MBL; TNF; cell summary = We demonstrate that Cw6 þ psoriasis patients had significant CD8 þ T-cell IFN-g responses to peptides from K17 and M6 protein selected on the basis of sequence homology and predicted HLA-Cw*0602 binding. The uptake of MBP by B cells and the presentation of MBP-derive peptides to T helper (Th) cells by B cells may be promoted by the formation of complement (C) activating immune complexes (ICs) between MBP and natural autoantibodies in healthy individuals and disease-associated anti-MBP antibodies in MS patients, respectively. While MBP did not induce measurable proliferation of B cells nor CD4 þ T cells, we observed the production of TNF-a, IFN-g and IL-10 by PBMC in response to incubation with MBP in the presence of sera from healthy controls as well as sera from MS patients. In conclusion, the results of this study suggest an involvement of the ASMase in the activation, expansion or maturation of virus-specific CD8 þ T cells during the acute infection of mice with the LCM virus. doi = 10.1111/j.0300-9475.2004.01423aw.x id = cord-023402-8qfmo6rq author = Reinholdt, J. title = Pneumococcal IgA1 Protease Activity Interferes with Opsonophagocytosis of Streptococcus Pneumoniae Mediated by Serotype‐Specific Human Monoclonal IgA1 Antibodies date = 2008-06-28 keywords = CD8; IFN; IL-12; MBL; TNF; cell summary = We demonstrate that Cw6 þ psoriasis patients had significant CD8 þ T-cell IFN-g responses to peptides from K17 and M6 protein selected on the basis of sequence homology and predicted HLA-Cw*0602 binding. The uptake of MBP by B cells and the presentation of MBP-derive peptides to T helper (Th) cells by B cells may be promoted by the formation of complement (C) activating immune complexes (ICs) between MBP and natural autoantibodies in healthy individuals and disease-associated anti-MBP antibodies in MS patients, respectively. While MBP did not induce measurable proliferation of B cells nor CD4 þ T cells, we observed the production of TNF-a, IFN-g and IL-10 by PBMC in response to incubation with MBP in the presence of sera from healthy controls as well as sera from MS patients. In conclusion, the results of this study suggest an involvement of the ASMase in the activation, expansion or maturation of virus-specific CD8 þ T cells during the acute infection of mice with the LCM virus. doi = 10.1111/j.0300-9475.2004.01423t.x id = cord-023429-x52gbklw author = Ruseva, M. title = Mannan‐Binding Lectin Inhibits Humoural Responses date = 2008-06-28 keywords = CD8; IFN; IL-12; MBL; TNF; cell summary = We demonstrate that Cw6 þ psoriasis patients had significant CD8 þ T-cell IFN-g responses to peptides from K17 and M6 protein selected on the basis of sequence homology and predicted HLA-Cw*0602 binding. The uptake of MBP by B cells and the presentation of MBP-derive peptides to T helper (Th) cells by B cells may be promoted by the formation of complement (C) activating immune complexes (ICs) between MBP and natural autoantibodies in healthy individuals and disease-associated anti-MBP antibodies in MS patients, respectively. While MBP did not induce measurable proliferation of B cells nor CD4 þ T cells, we observed the production of TNF-a, IFN-g and IL-10 by PBMC in response to incubation with MBP in the presence of sera from healthy controls as well as sera from MS patients. In conclusion, the results of this study suggest an involvement of the ASMase in the activation, expansion or maturation of virus-specific CD8 þ T cells during the acute infection of mice with the LCM virus. doi = 10.1111/j.0300-9475.2004.01423an.x id = cord-023425-3sjsogvq author = Røntved, C. M. title = Do High and Low Tumour Necrosis Factor‐α Responders Exist in Dairy Cows? date = 2008-06-28 keywords = CD8; IFN; IL-12; MBL; TNF; cell summary = We demonstrate that Cw6 þ psoriasis patients had significant CD8 þ T-cell IFN-g responses to peptides from K17 and M6 protein selected on the basis of sequence homology and predicted HLA-Cw*0602 binding. The uptake of MBP by B cells and the presentation of MBP-derive peptides to T helper (Th) cells by B cells may be promoted by the formation of complement (C) activating immune complexes (ICs) between MBP and natural autoantibodies in healthy individuals and disease-associated anti-MBP antibodies in MS patients, respectively. While MBP did not induce measurable proliferation of B cells nor CD4 þ T cells, we observed the production of TNF-a, IFN-g and IL-10 by PBMC in response to incubation with MBP in the presence of sera from healthy controls as well as sera from MS patients. In conclusion, the results of this study suggest an involvement of the ASMase in the activation, expansion or maturation of virus-specific CD8 þ T cells during the acute infection of mice with the LCM virus. doi = 10.1111/j.0300-9475.2004.01423v.x id = cord-311913-cplhq4k9 author = SATO, Satoshi title = Association of mannose‐binding lectin gene polymorphisms with Kawasaki disease in the Japanese date = 2009-11-23 keywords = MBL summary = Method: The frequencies of the genotypes, defined as mutations in codons 52, 54 and 57, and the functional promoter variants of the MBL were determined in 45 patients with KD. 11 MBL2 gene polymorphism at codon 54 has shown to be associated with systemic lupus erythematosus, 12,13 rheumatic disease, and common variable immunodeficiency. 10 In this study, the combination of codon-54 polymorphism and promoter variants in the MBL2 gene were significantly higher in the KD group than that in the control group (P < 0.05). This study has shown that, in a population of individuals born in Japan, having codon 54 variants in the MBL2 gene is significantly associated with susceptibility to KD but not with coronary arterial lesions. Association of mannose-binding lectin gene variation with disease severity and infections in a population-based cohort of systemic lupus erythematosus patients doi = 10.1111/j.1756-185x.2009.01428.x id = cord-023433-d1b7qvhs author = Siassi, M. title = Expression of Human Collectins in Colorectal Carcinoma date = 2008-06-28 keywords = CD8; IFN; IL-12; MBL; TNF; cell summary = We demonstrate that Cw6 þ psoriasis patients had significant CD8 þ T-cell IFN-g responses to peptides from K17 and M6 protein selected on the basis of sequence homology and predicted HLA-Cw*0602 binding. The uptake of MBP by B cells and the presentation of MBP-derive peptides to T helper (Th) cells by B cells may be promoted by the formation of complement (C) activating immune complexes (ICs) between MBP and natural autoantibodies in healthy individuals and disease-associated anti-MBP antibodies in MS patients, respectively. While MBP did not induce measurable proliferation of B cells nor CD4 þ T cells, we observed the production of TNF-a, IFN-g and IL-10 by PBMC in response to incubation with MBP in the presence of sera from healthy controls as well as sera from MS patients. In conclusion, the results of this study suggest an involvement of the ASMase in the activation, expansion or maturation of virus-specific CD8 þ T cells during the acute infection of mice with the LCM virus. doi = 10.1111/j.0300-9475.2004.01423bo.x id = cord-023431-zjyrhlxn author = Sigmundsdóttir, H. title = Differential Effects of Interleukin‐12 and Interleukin‐10 on Superantigen‐Induced Expression of Cutaneous Lymphocyte‐Associated Antigen and αEβ7 Integrin (CD103) by CD8(+) T cells date = 2008-06-28 keywords = CD8; IFN; IL-12; MBL; TNF; cell summary = We demonstrate that Cw6 þ psoriasis patients had significant CD8 þ T-cell IFN-g responses to peptides from K17 and M6 protein selected on the basis of sequence homology and predicted HLA-Cw*0602 binding. The uptake of MBP by B cells and the presentation of MBP-derive peptides to T helper (Th) cells by B cells may be promoted by the formation of complement (C) activating immune complexes (ICs) between MBP and natural autoantibodies in healthy individuals and disease-associated anti-MBP antibodies in MS patients, respectively. While MBP did not induce measurable proliferation of B cells nor CD4 þ T cells, we observed the production of TNF-a, IFN-g and IL-10 by PBMC in response to incubation with MBP in the presence of sera from healthy controls as well as sera from MS patients. In conclusion, the results of this study suggest an involvement of the ASMase in the activation, expansion or maturation of virus-specific CD8 þ T cells during the acute infection of mice with the LCM virus. doi = 10.1111/j.0300-9475.2004.01423ab.x id = cord-023419-lnmc6vv5 author = Steinhauer, C. title = High‐Throughput Proteomics on Antibody‐based Microarrays: the Importance of Probe and Surface Design date = 2008-06-28 keywords = CD8; IFN; IL-12; MBL; TNF; cell summary = We demonstrate that Cw6 þ psoriasis patients had significant CD8 þ T-cell IFN-g responses to peptides from K17 and M6 protein selected on the basis of sequence homology and predicted HLA-Cw*0602 binding. The uptake of MBP by B cells and the presentation of MBP-derive peptides to T helper (Th) cells by B cells may be promoted by the formation of complement (C) activating immune complexes (ICs) between MBP and natural autoantibodies in healthy individuals and disease-associated anti-MBP antibodies in MS patients, respectively. While MBP did not induce measurable proliferation of B cells nor CD4 þ T cells, we observed the production of TNF-a, IFN-g and IL-10 by PBMC in response to incubation with MBP in the presence of sera from healthy controls as well as sera from MS patients. In conclusion, the results of this study suggest an involvement of the ASMase in the activation, expansion or maturation of virus-specific CD8 þ T cells during the acute infection of mice with the LCM virus. doi = 10.1111/j.0300-9475.2004.01423ax.x id = cord-256769-flfycl7i author = Stoermer, Kristina A. title = Complement and Viral Pathogenesis date = 2011-03-01 keywords = HCV; MBL; complement summary = Taken together, these studies and the findings that multiple components of the complement pathway are required for mice to survive ectromelia virus infection (discussed below), indicate that complement activation and viral evasion of the complement system are critical determinants of poxvirus pathogenesis. Mice deficient in C3, C4, or CR2 (which in mice encodes both CR1 and CR2) had significantly diminished IgG responses following Herpes Simplex virus-1 (HSV-1) infection, suggesting that activation of the classical pathway plays a key role in regulating the antibody response to HSV-1 infection (Da Costa et al., 1999) . Unlike VSV infection, the genetic absence of C3 or CR2 resulted in increased WNV-induced mortality, earlier WNV entry into the central nervous system, and greater viral loads of WNV in the brains of mice, suggesting complement-mediated regulation of B cell responses was critical to control WNV dissemination, replication, and disease (Mehlhop et al., 2005) . doi = 10.1016/j.virol.2010.12.045 id = cord-023374-87ob1exq author = Sukhija, S. title = Levels, Complement Activity and Polymorphisms of Mannan‐Binding Lectin in Patients of Bronchial Asthma with Allergic Rhinitis date = 2008-06-28 keywords = CD8; IFN; IL-12; MBL; TNF; cell summary = We demonstrate that Cw6 þ psoriasis patients had significant CD8 þ T-cell IFN-g responses to peptides from K17 and M6 protein selected on the basis of sequence homology and predicted HLA-Cw*0602 binding. The uptake of MBP by B cells and the presentation of MBP-derive peptides to T helper (Th) cells by B cells may be promoted by the formation of complement (C) activating immune complexes (ICs) between MBP and natural autoantibodies in healthy individuals and disease-associated anti-MBP antibodies in MS patients, respectively. While MBP did not induce measurable proliferation of B cells nor CD4 þ T cells, we observed the production of TNF-a, IFN-g and IL-10 by PBMC in response to incubation with MBP in the presence of sera from healthy controls as well as sera from MS patients. In conclusion, the results of this study suggest an involvement of the ASMase in the activation, expansion or maturation of virus-specific CD8 þ T cells during the acute infection of mice with the LCM virus. doi = 10.1111/j.0300-9475.2004.01423ai.x id = cord-023421-1d1gf7az author = Sønder, S. U. S. title = Monitoring Patients Treated with Type 1 Interferons: Antiviral versus MxA Induction Assays date = 2008-06-28 keywords = CD8; IFN; IL-12; MBL; TNF; cell summary = We demonstrate that Cw6 þ psoriasis patients had significant CD8 þ T-cell IFN-g responses to peptides from K17 and M6 protein selected on the basis of sequence homology and predicted HLA-Cw*0602 binding. The uptake of MBP by B cells and the presentation of MBP-derive peptides to T helper (Th) cells by B cells may be promoted by the formation of complement (C) activating immune complexes (ICs) between MBP and natural autoantibodies in healthy individuals and disease-associated anti-MBP antibodies in MS patients, respectively. While MBP did not induce measurable proliferation of B cells nor CD4 þ T cells, we observed the production of TNF-a, IFN-g and IL-10 by PBMC in response to incubation with MBP in the presence of sera from healthy controls as well as sera from MS patients. In conclusion, the results of this study suggest an involvement of the ASMase in the activation, expansion or maturation of virus-specific CD8 þ T cells during the acute infection of mice with the LCM virus. doi = 10.1111/j.0300-9475.2004.01423bb.x id = cord-007375-hqmyund4 author = Tang, Yi-Wei title = Host Single-Nucleotide Polymorphisms and Altered Responses to Inactivated Influenza Vaccine date = 2007-10-01 keywords = IL-10; MBL-2; response summary = We analyzed the relationship between host gene polymorphisms and responses in recipients of inactivated influenza vaccine, who were classified into poor, normal, or adverse response groups. The frequency of the mannose-binding lectin-2 codon 54 allele was significantly different among the 3 types of responders, with a decreased odds ratio for the development of poor or adverse responses (P = .033). The present study explored the possibility that host gene polymorphisms influence inactivated influenza vaccineinduced immune responses by comparing the frequencies of 8 SNPs in the MBL-2 gene and in the TNF-a and IL-10 promoter regions among different groups. We found a significant difference in allele frequency in the MBL-2 codon 54 among the poor, normal, and adverse responders, suggesting that the allele polymorphism is independently associated with poor and adverse responses to influenza vaccination. These findings support the present data by suggesting that the Ϫ1082 allele polymorphism in the IL-10 promoter region may be associated with adverse responses induced by influenza vaccine. doi = 10.1086/521370 id = cord-282433-p6jl9gxf author = Tu, Xinyi title = Functional polymorphisms of the CCL2 and MBL genes cumulatively increase susceptibility to severe acute respiratory syndrome coronavirus infection date = 2015-03-27 keywords = CCL2; MBL; SARS summary = RESULTS: Both the high-CCL2-producing GG genotype and the low-MBL-producing B allele were consistently associated with increased risks of SARS-CoV infection in all 4 case–control populations (joint P = 1.6 × 10(−4) and 4.9 × 10(−8), for CCL2 and MBL respectively), with no interaction between polymorphisms could be detected. 3À10 In particular, our previous two independent association studies have implicated that a functional polymorphism at codon 54 in exon 1 (rs1800450, G230A, denoted as A/B variant) of mannose binding lectin (MBL), which encodes a protein belonging to the family of collectin and plays a critical role in the innate immune response, conferred a significantly increased susceptibility to SARS-CoV infection. Taken together, the large size of the investigation, the consistency of the observations in 4 independent caseecontrol series and the low P values distinguish our study from previous studies investigating the influence of different other polymorphisms on the development of SARS, and strengthen the association between the CCL2 G-2518A and MBL codon 54 variant (A/B) and susceptibility to SARS-CoV infection. doi = 10.1016/j.jinf.2015.03.006 id = cord-023391-bq5w3jk9 author = Utermöhlen, O. title = Delayed Elimination of the LCM Virus from Acid Sphingomyelinase‐Deficient Mice due to Reduced Expansion of Virus‐Specific CD8(+) T Lymphocytes date = 2008-06-28 keywords = CD8; IFN; IL-12; MBL; TNF; cell summary = We demonstrate that Cw6 þ psoriasis patients had significant CD8 þ T-cell IFN-g responses to peptides from K17 and M6 protein selected on the basis of sequence homology and predicted HLA-Cw*0602 binding. The uptake of MBP by B cells and the presentation of MBP-derive peptides to T helper (Th) cells by B cells may be promoted by the formation of complement (C) activating immune complexes (ICs) between MBP and natural autoantibodies in healthy individuals and disease-associated anti-MBP antibodies in MS patients, respectively. While MBP did not induce measurable proliferation of B cells nor CD4 þ T cells, we observed the production of TNF-a, IFN-g and IL-10 by PBMC in response to incubation with MBP in the presence of sera from healthy controls as well as sera from MS patients. In conclusion, the results of this study suggest an involvement of the ASMase in the activation, expansion or maturation of virus-specific CD8 þ T cells during the acute infection of mice with the LCM virus. doi = 10.1111/j.0300-9475.2004.01423l.x id = cord-023417-by18aczt author = Vilhelmsson, M. title = The Malassezia sympodialis Allergen Mala s 11 with Sequence Similarity to Manganese Superoxide Dismutase Induces Maturation and Production of Inflammatory Cytokines in Human Dendritic Cells date = 2008-06-28 keywords = CD8; IFN; IL-12; MBL; TNF; cell summary = We demonstrate that Cw6 þ psoriasis patients had significant CD8 þ T-cell IFN-g responses to peptides from K17 and M6 protein selected on the basis of sequence homology and predicted HLA-Cw*0602 binding. The uptake of MBP by B cells and the presentation of MBP-derive peptides to T helper (Th) cells by B cells may be promoted by the formation of complement (C) activating immune complexes (ICs) between MBP and natural autoantibodies in healthy individuals and disease-associated anti-MBP antibodies in MS patients, respectively. While MBP did not induce measurable proliferation of B cells nor CD4 þ T cells, we observed the production of TNF-a, IFN-g and IL-10 by PBMC in response to incubation with MBP in the presence of sera from healthy controls as well as sera from MS patients. In conclusion, the results of this study suggest an involvement of the ASMase in the activation, expansion or maturation of virus-specific CD8 þ T cells during the acute infection of mice with the LCM virus. doi = 10.1111/j.0300-9475.2004.01423ae.x id = cord-304718-w469n0o8 author = Wang, Yan title = Lack of association between polymorphisms of MASP2 and susceptibility to SARS coronavirus infection date = 2009-05-01 keywords = MASP2; MBL; SARS summary = One case-control study has reported an association between susceptibility to SARS and mannan-binding lectin (MBL) in China. As the downstream protein of MBL, variants of the MBL-associated serine protease-2 (MASP2) gene may be associated with SARS coronavirus (SARS-CoV) infection in the same population. RESULTS: There is no significant association between alleles or genotypes of the MASP2 tagSNP and susceptibility to SARS-CoV in both Beijing and Guangzhou populations. A few case-control studies have reported an association between SARS susceptibility and human leucocyte antigen (HLA) and MBL [8] [9] [10] [11] . With regard to SARS-CoV infection, the codon 54 variant of the MBL gene has been shown to be associated with infection susceptibility but not with disease severity [11] . As the downstream protein of MBL, variants of the MASP2 gene may be associated with SARS-CoV infection. Genomic DNA from 30 individuals with SARS was chosen for analysis of MASP2 gene polymorphisms. doi = 10.1186/1471-2334-9-51 id = cord-023389-ilrp8vb7 author = Wefer, J. title = Protective DNA Vaccination Against MOG(91‐108)‐Induced Experimental Autoimmune Encephalomyelitis Involves Induction of IFNβ date = 2008-06-28 keywords = CD8; IFN; IL-12; MBL; TNF; cell; dna summary = We demonstrate that Cw6 þ psoriasis patients had significant CD8 þ T-cell IFN-g responses to peptides from K17 and M6 protein selected on the basis of sequence homology and predicted HLA-Cw*0602 binding. The uptake of MBP by B cells and the presentation of MBP-derive peptides to T helper (Th) cells by B cells may be promoted by the formation of complement (C) activating immune complexes (ICs) between MBP and natural autoantibodies in healthy individuals and disease-associated anti-MBP antibodies in MS patients, respectively. While MBP did not induce measurable proliferation of B cells nor CD4 þ T cells, we observed the production of TNF-a, IFN-g and IL-10 by PBMC in response to incubation with MBP in the presence of sera from healthy controls as well as sera from MS patients. In conclusion, the results of this study suggest an involvement of the ASMase in the activation, expansion or maturation of virus-specific CD8 þ T cells during the acute infection of mice with the LCM virus. doi = 10.1111/j.0300-9475.2004.01423j.x id = cord-023443-pvz7dll9 author = nan title = Abstracts for the Scandinavian Society for Immunology 35th Annual Meeting and 20th Summer School date = 2004-06-02 keywords = CD8; IFN; IL-12; MBL; TNF; cell summary = We demonstrate that Cw6 þ psoriasis patients had significant CD8 þ T-cell IFN-g responses to peptides from K17 and M6 protein selected on the basis of sequence homology and predicted HLA-Cw*0602 binding. The uptake of MBP by B cells and the presentation of MBP-derive peptides to T helper (Th) cells by B cells may be promoted by the formation of complement (C) activating immune complexes (ICs) between MBP and natural autoantibodies in healthy individuals and disease-associated anti-MBP antibodies in MS patients, respectively. While MBP did not induce measurable proliferation of B cells nor CD4 þ T cells, we observed the production of TNF-a, IFN-g and IL-10 by PBMC in response to incubation with MBP in the presence of sera from healthy controls as well as sera from MS patients. In conclusion, the results of this study suggest an involvement of the ASMase in the activation, expansion or maturation of virus-specific CD8 þ T cells during the acute infection of mice with the LCM virus. doi = 10.1111/j.1365-3083.2004.01423.x