id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-272666-3uidpr79	Doyle, Nicole	Infectious Bronchitis Virus Nonstructural Protein 4 Alone Induces Membrane Pairing	2018-09-06		.txt	text/plain	7472	358	52	In this study, membrane rearrangements induced when expressing viral non-structural proteins (nsps) from two different strains of IBV were compared. In contrast to previously studied coronaviruses, IBV nsp4 alone is necessary and sufficient to induce membrane pairing; however, expression of the transmembrane proteins together was not sufficient to fully recapitulate DMVs. This indicates that although nsp4 is able to singularly induce membrane pairing, further viral or host factors are required in order to fully assemble IBV replicative structures. In a subsequent study by others, it was shown that expression of only nsp3 and 4 from either MERS-CoV or SARS-CoV was able to induce DMV formation, and furthermore, addition of nsp6 made no difference to their shape or size, and did not induce the spherule-like structures seen following infection with whole virus [26] .	./cache/cord-272666-3uidpr79.txt	./txt/cord-272666-3uidpr79.txt