id	sid	tid	token	lemma	pos
cord-016938-pk76snuy	1	1	key	key	JJ
cord-016938-pk76snuy	1	2	:	:	:
cord-016938-pk76snuy	1	3	cord-016938-pk76snuy	cord-016938-pk76snuy	NN
cord-016938-pk76snuy	1	4	authors	author	NNS
cord-016938-pk76snuy	1	5	:	:	:
cord-016938-pk76snuy	1	6	Suh	Suh	NNP
cord-016938-pk76snuy	1	7	,	,	,
cord-016938-pk76snuy	1	8	Hwal	Hwal	NNP
cord-016938-pk76snuy	1	9	(	(	-LRB-
cord-016938-pk76snuy	1	10	Matthew	Matthew	NNP
cord-016938-pk76snuy	1	11	)	)	-RRB-
cord-016938-pk76snuy	1	12	title	title	NN
cord-016938-pk76snuy	1	13	:	:	:
cord-016938-pk76snuy	1	14	Collagen	Collagen	NNP
cord-016938-pk76snuy	1	15	Fabrication	Fabrication	NNP
cord-016938-pk76snuy	1	16	for	for	IN
cord-016938-pk76snuy	1	17	the	the	DT
cord-016938-pk76snuy	1	18	Cell	cell	NN
cord-016938-pk76snuy	1	19	-	-	HYPH
cord-016938-pk76snuy	1	20	based	base	VBN
cord-016938-pk76snuy	1	21	Implants	implant	NNS
cord-016938-pk76snuy	1	22	in	in	IN
cord-016938-pk76snuy	1	23	Regenerative	Regenerative	NNP
cord-016938-pk76snuy	1	24	Medicine	Medicine	NNP
cord-016938-pk76snuy	1	25	date	date	NN
cord-016938-pk76snuy	1	26	:	:	:
cord-016938-pk76snuy	1	27	2008	2008	CD
cord-016938-pk76snuy	1	28	journal	journal	NN
cord-016938-pk76snuy	1	29	:	:	:
cord-016938-pk76snuy	1	30	Bioengineering	bioengineering	NN
cord-016938-pk76snuy	1	31	in	in	IN
cord-016938-pk76snuy	1	32	Cell	Cell	NNP
cord-016938-pk76snuy	1	33	and	and	CC
cord-016938-pk76snuy	1	34	Tissue	Tissue	NNP
cord-016938-pk76snuy	1	35	Research	Research	NNP
cord-016938-pk76snuy	2	1	DOI	DOI	NNP
cord-016938-pk76snuy	2	2	:	:	:
cord-016938-pk76snuy	2	3	10.1007/978	10.1007/978	CD
cord-016938-pk76snuy	2	4	-	-	HYPH
cord-016938-pk76snuy	2	5	3	3	CD
cord-016938-pk76snuy	2	6	-	-	HYPH
cord-016938-pk76snuy	2	7	540	540	CD
cord-016938-pk76snuy	2	8	-	-	HYPH
cord-016938-pk76snuy	2	9	75409	75409	CD
cord-016938-pk76snuy	2	10	-	-	SYM
cord-016938-pk76snuy	2	11	1_8	1_8	CD
cord-016938-pk76snuy	2	12	sha	sha	NNP
cord-016938-pk76snuy	2	13	:	:	:
cord-016938-pk76snuy	3	1	866f923f5f41ec09ddec68d8db463d829b99a1f3	866f923f5f41ec09ddec68d8db463d829b99a1f3	CD
cord-016938-pk76snuy	3	2	doc_id	doc_id	CD
cord-016938-pk76snuy	3	3	:	:	:
cord-016938-pk76snuy	3	4	16938	16938	CD
cord-016938-pk76snuy	3	5	cord_uid	cord_uid	NNS
cord-016938-pk76snuy	3	6	:	:	:
cord-016938-pk76snuy	3	7	pk76snuy	pk76snuy	NNP
cord-016938-pk76snuy	4	1	Though	though	IN
cord-016938-pk76snuy	4	2	transplantation	transplantation	NN
cord-016938-pk76snuy	4	3	of	of	IN
cord-016938-pk76snuy	4	4	cells	cell	NNS
cord-016938-pk76snuy	4	5	,	,	,
cord-016938-pk76snuy	4	6	tissue	tissue	NN
cord-016938-pk76snuy	4	7	or	or	CC
cord-016938-pk76snuy	4	8	organ	organ	NN
cord-016938-pk76snuy	4	9	has	have	VBZ
cord-016938-pk76snuy	4	10	been	be	VBN
cord-016938-pk76snuy	4	11	regarded	regard	VBN
cord-016938-pk76snuy	4	12	as	as	IN
cord-016938-pk76snuy	4	13	an	an	DT
cord-016938-pk76snuy	4	14	ideal	ideal	JJ
cord-016938-pk76snuy	4	15	approach	approach	NN
cord-016938-pk76snuy	4	16	,	,	,
cord-016938-pk76snuy	4	17	scarcity	scarcity	NN
cord-016938-pk76snuy	4	18	of	of	IN
cord-016938-pk76snuy	4	19	donor	donor	NN
cord-016938-pk76snuy	4	20	is	be	VBZ
cord-016938-pk76snuy	4	21	a	a	DT
cord-016938-pk76snuy	4	22	practical	practical	JJ
cord-016938-pk76snuy	4	23	barrier	barrier	NN
cord-016938-pk76snuy	4	24	in	in	IN
cord-016938-pk76snuy	4	25	clinics	clinic	NNS
cord-016938-pk76snuy	4	26	.	.	.
cord-016938-pk76snuy	5	1	Current	current	JJ
cord-016938-pk76snuy	5	2	progresses	progress	NNS
cord-016938-pk76snuy	5	3	in	in	IN
cord-016938-pk76snuy	5	4	cell	cell	NN
cord-016938-pk76snuy	5	5	engineering	engineering	NN
cord-016938-pk76snuy	5	6	has	have	VBZ
cord-016938-pk76snuy	5	7	opened	open	VBN
cord-016938-pk76snuy	5	8	a	a	DT
cord-016938-pk76snuy	5	9	new	new	JJ
cord-016938-pk76snuy	5	10	era	era	NN
cord-016938-pk76snuy	5	11	,	,	,
cord-016938-pk76snuy	5	12	providing	provide	VBG
cord-016938-pk76snuy	5	13	tools	tool	NNS
cord-016938-pk76snuy	5	14	for	for	IN
cord-016938-pk76snuy	5	15	host	host	NN
cord-016938-pk76snuy	5	16	-	-	HYPH
cord-016938-pk76snuy	5	17	regeneration	regeneration	NN
cord-016938-pk76snuy	5	18	by	by	IN
cord-016938-pk76snuy	5	19	implanting	implant	VBG
cord-016938-pk76snuy	5	20	manipulated	manipulate	VBN
cord-016938-pk76snuy	5	21	cells	cell	NNS
cord-016938-pk76snuy	5	22	in	in	IN
cord-016938-pk76snuy	5	23	forms	form	NNS
cord-016938-pk76snuy	5	24	of	of	IN
cord-016938-pk76snuy	5	25	cell	cell	NN
cord-016938-pk76snuy	5	26	therapy	therapy	NN
cord-016938-pk76snuy	5	27	,	,	,
cord-016938-pk76snuy	5	28	which	which	WDT
cord-016938-pk76snuy	5	29	includes	include	VBZ
cord-016938-pk76snuy	5	30	delivery	delivery	NN
cord-016938-pk76snuy	5	31	of	of	IN
cord-016938-pk76snuy	5	32	single	single	JJ
cord-016938-pk76snuy	5	33	cells	cell	NNS
cord-016938-pk76snuy	5	34	or	or	CC
cord-016938-pk76snuy	5	35	multicellular	multicellular	JJ
cord-016938-pk76snuy	5	36	structural	structural	JJ
cord-016938-pk76snuy	5	37	support	support	NN
cord-016938-pk76snuy	5	38	of	of	IN
cord-016938-pk76snuy	5	39	hybridized	hybridized	JJ
cord-016938-pk76snuy	5	40	cells	cell	NNS
cord-016938-pk76snuy	5	41	,	,	,
cord-016938-pk76snuy	5	42	as	as	IN
cord-016938-pk76snuy	5	43	a	a	DT
cord-016938-pk76snuy	5	44	representative	representative	JJ
cord-016938-pk76snuy	5	45	individualized	individualized	JJ
cord-016938-pk76snuy	5	46	treatment	treatment	NN
cord-016938-pk76snuy	5	47	method	method	NN
cord-016938-pk76snuy	5	48	.	.	.
cord-016938-pk76snuy	6	1	This	this	DT
cord-016938-pk76snuy	6	2	chapter	chapter	NN
cord-016938-pk76snuy	6	3	mainly	mainly	RB
cord-016938-pk76snuy	6	4	concerns	concern	NNS
cord-016938-pk76snuy	6	5	on	on	IN
cord-016938-pk76snuy	6	6	the	the	DT
cord-016938-pk76snuy	6	7	cellbased	cellbase	VBN
cord-016938-pk76snuy	6	8	implant	implant	NNP
cord-016938-pk76snuy	6	9	made	make	VBN
cord-016938-pk76snuy	6	10	of	of	IN
cord-016938-pk76snuy	6	11	cells	cell	NNS
cord-016938-pk76snuy	6	12	and	and	CC
cord-016938-pk76snuy	6	13	collagen	collagen	NN
cord-016938-pk76snuy	6	14	,	,	,
cord-016938-pk76snuy	6	15	the	the	DT
cord-016938-pk76snuy	6	16	main	main	JJ
cord-016938-pk76snuy	6	17	structural	structural	JJ
cord-016938-pk76snuy	6	18	protein	protein	NN
cord-016938-pk76snuy	6	19	in	in	IN
cord-016938-pk76snuy	6	20	extracellular	extracellular	JJ
cord-016938-pk76snuy	6	21	matrix	matrix	NN
cord-016938-pk76snuy	6	22	in	in	IN
cord-016938-pk76snuy	6	23	mammalian	mammalian	JJ
cord-016938-pk76snuy	6	24	tissue	tissue	NN
cord-016938-pk76snuy	6	25	,	,	,
cord-016938-pk76snuy	6	26	as	as	IN
cord-016938-pk76snuy	6	27	it	-PRON-	PRP
cord-016938-pk76snuy	6	28	has	have	VBZ
cord-016938-pk76snuy	6	29	been	be	VBN
cord-016938-pk76snuy	6	30	regarded	regard	VBN
cord-016938-pk76snuy	6	31	as	as	IN
cord-016938-pk76snuy	6	32	a	a	DT
cord-016938-pk76snuy	6	33	promising	promising	JJ
cord-016938-pk76snuy	6	34	method	method	NN
cord-016938-pk76snuy	6	35	for	for	IN
cord-016938-pk76snuy	6	36	manufacturing	manufacture	VBG
cord-016938-pk76snuy	6	37	a	a	DT
cord-016938-pk76snuy	6	38	biologically	biologically	RB
cord-016938-pk76snuy	6	39	mimicked	mimic	VBN
cord-016938-pk76snuy	6	40	artificial	artificial	JJ
cord-016938-pk76snuy	6	41	tissues	tissue	NNS
cord-016938-pk76snuy	6	42	.	.	.
cord-016938-pk76snuy	7	1	Regenerative	regenerative	JJ
cord-016938-pk76snuy	7	2	medicine	medicine	NN
cord-016938-pk76snuy	7	3	is	be	VBZ
cord-016938-pk76snuy	7	4	to	to	TO
cord-016938-pk76snuy	7	5	repair	repair	VB
cord-016938-pk76snuy	7	6	,	,	,
cord-016938-pk76snuy	7	7	replace	replace	VB
cord-016938-pk76snuy	7	8	and/or	and/or	CC
cord-016938-pk76snuy	7	9	modify	modify	VB
cord-016938-pk76snuy	7	10	the	the	DT
cord-016938-pk76snuy	7	11	disordered	disordered	JJ
cord-016938-pk76snuy	7	12	or	or	CC
cord-016938-pk76snuy	7	13	damaged	damage	VBN
cord-016938-pk76snuy	7	14	human	human	JJ
cord-016938-pk76snuy	7	15	body	body	NN
cord-016938-pk76snuy	7	16	,	,	,
cord-016938-pk76snuy	7	17	either	either	CC
cord-016938-pk76snuy	7	18	from	from	IN
cord-016938-pk76snuy	7	19	a	a	DT
cord-016938-pk76snuy	7	20	disease	disease	NN
cord-016938-pk76snuy	7	21	and/or	and/or	CC
cord-016938-pk76snuy	7	22	an	an	DT
cord-016938-pk76snuy	7	23	injury	injury	NN
cord-016938-pk76snuy	7	24	,	,	,
cord-016938-pk76snuy	7	25	via	via	IN
cord-016938-pk76snuy	7	26	functional	functional	JJ
cord-016938-pk76snuy	7	27	regeneration	regeneration	NN
cord-016938-pk76snuy	7	28	of	of	IN
cord-016938-pk76snuy	7	29	the	the	DT
cord-016938-pk76snuy	7	30	host	host	NN
cord-016938-pk76snuy	7	31	cells	cell	NNS
cord-016938-pk76snuy	7	32	,	,	,
cord-016938-pk76snuy	7	33	tissues	tissue	NNS
cord-016938-pk76snuy	7	34	and	and	CC
cord-016938-pk76snuy	7	35	organs	organ	NNS
cord-016938-pk76snuy	7	36	by	by	IN
cord-016938-pk76snuy	7	37	placing	place	VBG
cord-016938-pk76snuy	7	38	appropriate	appropriate	JJ
cord-016938-pk76snuy	7	39	cells	cell	NNS
cord-016938-pk76snuy	7	40	of	of	IN
cord-016938-pk76snuy	7	41	optimal	optimal	JJ
cord-016938-pk76snuy	7	42	quantity	quantity	NN
cord-016938-pk76snuy	7	43	into	into	IN
cord-016938-pk76snuy	7	44	the	the	DT
cord-016938-pk76snuy	7	45	damaged	damage	VBN
cord-016938-pk76snuy	7	46	body	body	NN
cord-016938-pk76snuy	7	47	and	and	CC
cord-016938-pk76snuy	7	48	maintaining	maintain	VBG
cord-016938-pk76snuy	7	49	the	the	DT
cord-016938-pk76snuy	7	50	cellular	cellular	JJ
cord-016938-pk76snuy	7	51	functions	function	NNS
cord-016938-pk76snuy	7	52	that	that	WDT
cord-016938-pk76snuy	7	53	provide	provide	VBP
cord-016938-pk76snuy	7	54	expected	expect	VBN
cord-016938-pk76snuy	7	55	efficacy	efficacy	NN
cord-016938-pk76snuy	7	56	.	.	.
cord-016938-pk76snuy	8	1	Outcome	outcome	NN
cord-016938-pk76snuy	8	2	of	of	IN
cord-016938-pk76snuy	8	3	the	the	DT
cord-016938-pk76snuy	8	4	regenerative	regenerative	JJ
cord-016938-pk76snuy	8	5	medical	medical	JJ
cord-016938-pk76snuy	8	6	treatment	treatment	NN
cord-016938-pk76snuy	8	7	completely	completely	RB
cord-016938-pk76snuy	8	8	depends	depend	VBZ
cord-016938-pk76snuy	8	9	on	on	IN
cord-016938-pk76snuy	8	10	the	the	DT
cord-016938-pk76snuy	8	11	viability	viability	NN
cord-016938-pk76snuy	8	12	of	of	IN
cord-016938-pk76snuy	8	13	delivered	deliver	VBN
cord-016938-pk76snuy	8	14	cells	cell	NNS
cord-016938-pk76snuy	8	15	.	.	.
cord-016938-pk76snuy	9	1	Embedding	embed	VBG
cord-016938-pk76snuy	9	2	and	and	CC
cord-016938-pk76snuy	9	3	planting	planting	NN
cord-016938-pk76snuy	9	4	,	,	,
cord-016938-pk76snuy	9	5	referred	refer	VBD
cord-016938-pk76snuy	9	6	to	to	IN
cord-016938-pk76snuy	9	7	as	as	IN
cord-016938-pk76snuy	9	8	implantation	implantation	NN
cord-016938-pk76snuy	9	9	,	,	,
cord-016938-pk76snuy	9	10	of	of	IN
cord-016938-pk76snuy	9	11	devices	device	NNS
cord-016938-pk76snuy	9	12	made	make	VBN
cord-016938-pk76snuy	9	13	of	of	IN
cord-016938-pk76snuy	9	14	biocompatible	biocompatible	JJ
cord-016938-pk76snuy	9	15	materials	material	NNS
cord-016938-pk76snuy	9	16	has	have	VBZ
cord-016938-pk76snuy	9	17	been	be	VBN
cord-016938-pk76snuy	9	18	widely	widely	RB
cord-016938-pk76snuy	9	19	applied	apply	VBN
cord-016938-pk76snuy	9	20	.	.	.
cord-016938-pk76snuy	10	1	Metals	metal	NNS
cord-016938-pk76snuy	10	2	,	,	,
cord-016938-pk76snuy	10	3	ceramics	ceramic	NNS
cord-016938-pk76snuy	10	4	,	,	,
cord-016938-pk76snuy	10	5	synthetic	synthetic	JJ
cord-016938-pk76snuy	10	6	and	and	CC
cord-016938-pk76snuy	10	7	natural	natural	JJ
cord-016938-pk76snuy	10	8	polymers	polymer	NNS
cord-016938-pk76snuy	10	9	are	be	VBP
cord-016938-pk76snuy	10	10	the	the	DT
cord-016938-pk76snuy	10	11	fundamental	fundamental	JJ
cord-016938-pk76snuy	10	12	biomaterials	biomaterial	NNS
cord-016938-pk76snuy	10	13	that	that	WDT
cord-016938-pk76snuy	10	14	are	be	VBP
cord-016938-pk76snuy	10	15	convenient	convenient	JJ
cord-016938-pk76snuy	10	16	for	for	IN
cord-016938-pk76snuy	10	17	processing	process	VBG
cord-016938-pk76snuy	10	18	and	and	CC
cord-016938-pk76snuy	10	19	fabricating	fabricate	VBG
cord-016938-pk76snuy	10	20	into	into	IN
cord-016938-pk76snuy	10	21	various	various	JJ
cord-016938-pk76snuy	10	22	forms	form	NNS
cord-016938-pk76snuy	10	23	of	of	IN
cord-016938-pk76snuy	10	24	tissue	tissue	NN
cord-016938-pk76snuy	10	25	supporting	support	VBG
cord-016938-pk76snuy	10	26	structures	structure	NNS
cord-016938-pk76snuy	10	27	.	.	.
cord-016938-pk76snuy	11	1	However	however	RB
cord-016938-pk76snuy	11	2	,	,	,
cord-016938-pk76snuy	11	3	lack	lack	NN
cord-016938-pk76snuy	11	4	of	of	IN
cord-016938-pk76snuy	11	5	their	-PRON-	PRP$
cord-016938-pk76snuy	11	6	biological	biological	JJ
cord-016938-pk76snuy	11	7	function	function	NN
cord-016938-pk76snuy	11	8	is	be	VBZ
cord-016938-pk76snuy	11	9	too	too	RB
cord-016938-pk76snuy	11	10	far	far	RB
cord-016938-pk76snuy	11	11	from	from	IN
cord-016938-pk76snuy	11	12	the	the	DT
cord-016938-pk76snuy	11	13	ideal	ideal	JJ
cord-016938-pk76snuy	11	14	goal	goal	NN
cord-016938-pk76snuy	11	15	for	for	IN
cord-016938-pk76snuy	11	16	treatment	treatment	NN
cord-016938-pk76snuy	11	17	.	.	.
cord-016938-pk76snuy	12	1	From	from	IN
cord-016938-pk76snuy	12	2	this	this	DT
cord-016938-pk76snuy	12	3	perspective	perspective	NN
cord-016938-pk76snuy	12	4	,	,	,
cord-016938-pk76snuy	12	5	transplantation	transplantation	NN
cord-016938-pk76snuy	12	6	which	which	WDT
cord-016938-pk76snuy	12	7	involves	involve	VBZ
cord-016938-pk76snuy	12	8	transferring	transfer	VBG
cord-016938-pk76snuy	12	9	procured	procure	VBN
cord-016938-pk76snuy	12	10	cells	cell	NNS
cord-016938-pk76snuy	12	11	,	,	,
cord-016938-pk76snuy	12	12	tissue	tissue	NN
cord-016938-pk76snuy	12	13	or	or	CC
cord-016938-pk76snuy	12	14	organ	organ	NN
cord-016938-pk76snuy	12	15	from	from	IN
cord-016938-pk76snuy	12	16	a	a	DT
cord-016938-pk76snuy	12	17	donor	donor	NN
cord-016938-pk76snuy	12	18	and	and	CC
cord-016938-pk76snuy	12	19	planting	planting	NN
cord-016938-pk76snuy	12	20	into	into	IN
cord-016938-pk76snuy	12	21	a	a	DT
cord-016938-pk76snuy	12	22	recipient	recipient	NN
cord-016938-pk76snuy	12	23	to	to	TO
cord-016938-pk76snuy	12	24	replace	replace	VB
cord-016938-pk76snuy	12	25	the	the	DT
cord-016938-pk76snuy	12	26	damaged	damage	VBN
cord-016938-pk76snuy	12	27	lesion	lesion	NN
cord-016938-pk76snuy	12	28	has	have	VBZ
cord-016938-pk76snuy	12	29	been	be	VBN
cord-016938-pk76snuy	12	30	regarded	regard	VBN
cord-016938-pk76snuy	12	31	as	as	IN
cord-016938-pk76snuy	12	32	an	an	DT
cord-016938-pk76snuy	12	33	ideal	ideal	JJ
cord-016938-pk76snuy	12	34	approach	approach	NN
cord-016938-pk76snuy	12	35	that	that	WDT
cord-016938-pk76snuy	12	36	provides	provide	VBZ
cord-016938-pk76snuy	12	37	biological	biological	JJ
cord-016938-pk76snuy	12	38	restoration	restoration	NN
cord-016938-pk76snuy	12	39	with	with	IN
cord-016938-pk76snuy	12	40	recovery	recovery	NN
cord-016938-pk76snuy	12	41	of	of	IN
cord-016938-pk76snuy	12	42	physiological	physiological	JJ
cord-016938-pk76snuy	12	43	functions	function	NNS
cord-016938-pk76snuy	12	44	.	.	.
cord-016938-pk76snuy	13	1	Nevertheless	nevertheless	RB
cord-016938-pk76snuy	13	2	,	,	,
cord-016938-pk76snuy	13	3	the	the	DT
cord-016938-pk76snuy	13	4	opportunity	opportunity	NN
cord-016938-pk76snuy	13	5	for	for	IN
cord-016938-pk76snuy	13	6	selection	selection	NN
cord-016938-pk76snuy	13	7	of	of	IN
cord-016938-pk76snuy	13	8	the	the	DT
cord-016938-pk76snuy	13	9	completely	completely	RB
cord-016938-pk76snuy	13	10	perfect	perfect	JJ
cord-016938-pk76snuy	13	11	donor	donor	NN
cord-016938-pk76snuy	13	12	for	for	IN
cord-016938-pk76snuy	13	13	a	a	DT
cord-016938-pk76snuy	13	14	patient	patient	NN
cord-016938-pk76snuy	13	15	is	be	VBZ
cord-016938-pk76snuy	13	16	critically	critically	RB
cord-016938-pk76snuy	13	17	limited	limit	VBN
cord-016938-pk76snuy	13	18	in	in	IN
cord-016938-pk76snuy	13	19	practice	practice	NN
cord-016938-pk76snuy	13	20	.	.	.
cord-016938-pk76snuy	14	1	The	the	DT
cord-016938-pk76snuy	14	2	gene	gene	NN
cord-016938-pk76snuy	14	3	-	-	HYPH
cord-016938-pk76snuy	14	4	homogeneity	homogeneity	NN
cord-016938-pk76snuy	14	5	between	between	IN
cord-016938-pk76snuy	14	6	the	the	DT
cord-016938-pk76snuy	14	7	donor	donor	NN
cord-016938-pk76snuy	14	8	and	and	CC
cord-016938-pk76snuy	14	9	recipient	recipient	NN
cord-016938-pk76snuy	14	10	,	,	,
cord-016938-pk76snuy	14	11	mainly	mainly	RB
cord-016938-pk76snuy	14	12	in	in	IN
cord-016938-pk76snuy	14	13	human	human	JJ
cord-016938-pk76snuy	14	14	leukocyte	leukocyte	NN
cord-016938-pk76snuy	14	15	antigen	antigen	NN
cord-016938-pk76snuy	14	16	(	(	-LRB-
cord-016938-pk76snuy	14	17	HLA	HLA	NNP
cord-016938-pk76snuy	14	18	)	)	-RRB-
cord-016938-pk76snuy	14	19	types	type	NNS
cord-016938-pk76snuy	14	20	,	,	,
cord-016938-pk76snuy	14	21	is	be	VBZ
cord-016938-pk76snuy	14	22	the	the	DT
cord-016938-pk76snuy	14	23	first	first	JJ
cord-016938-pk76snuy	14	24	factor	factor	NN
cord-016938-pk76snuy	14	25	to	to	TO
cord-016938-pk76snuy	14	26	avoid	avoid	VB
cord-016938-pk76snuy	14	27	any	any	DT
cord-016938-pk76snuy	14	28	post	post	JJ
cord-016938-pk76snuy	14	29	-	-	JJ
cord-016938-pk76snuy	14	30	operative	operative	JJ
cord-016938-pk76snuy	14	31	complication	complication	NN
cord-016938-pk76snuy	14	32	oriented	orient	VBN
cord-016938-pk76snuy	14	33	from	from	IN
cord-016938-pk76snuy	14	34	the	the	DT
cord-016938-pk76snuy	14	35	immune	immune	JJ
cord-016938-pk76snuy	14	36	responses	response	NNS
cord-016938-pk76snuy	14	37	.	.	.
cord-016938-pk76snuy	15	1	Although	although	IN
cord-016938-pk76snuy	15	2	autologous	autologous	JJ
cord-016938-pk76snuy	15	3	tissue	tissue	NN
cord-016938-pk76snuy	15	4	is	be	VBZ
cord-016938-pk76snuy	15	5	the	the	DT
cord-016938-pk76snuy	15	6	most	most	RBS
cord-016938-pk76snuy	15	7	appropriate	appropriate	JJ
cord-016938-pk76snuy	15	8	if	if	IN
cord-016938-pk76snuy	15	9	damage	damage	NN
cord-016938-pk76snuy	15	10	or	or	CC
cord-016938-pk76snuy	15	11	defect	defect	NN
cord-016938-pk76snuy	15	12	is	be	VBZ
cord-016938-pk76snuy	15	13	not	not	RB
cord-016938-pk76snuy	15	14	related	relate	VBN
cord-016938-pk76snuy	15	15	to	to	IN
cord-016938-pk76snuy	15	16	immune	immune	JJ
cord-016938-pk76snuy	15	17	disease	disease	NN
cord-016938-pk76snuy	15	18	,	,	,
cord-016938-pk76snuy	15	19	applicable	applicable	JJ
cord-016938-pk76snuy	15	20	size	size	NN
cord-016938-pk76snuy	15	21	and	and	CC
cord-016938-pk76snuy	15	22	volume	volume	NN
cord-016938-pk76snuy	15	23	of	of	IN
cord-016938-pk76snuy	15	24	donor	donor	NN
cord-016938-pk76snuy	15	25	site	site	NN
cord-016938-pk76snuy	15	26	are	be	VBP
cord-016938-pk76snuy	15	27	extremely	extremely	RB
cord-016938-pk76snuy	15	28	limited	limited	JJ
cord-016938-pk76snuy	15	29	.	.	.
cord-016938-pk76snuy	16	1	Allogeneic	allogeneic	IN
cord-016938-pk76snuy	16	2	tissue	tissue	NN
cord-016938-pk76snuy	16	3	has	have	VBZ
cord-016938-pk76snuy	16	4	been	be	VBN
cord-016938-pk76snuy	16	5	the	the	DT
cord-016938-pk76snuy	16	6	second	second	JJ
cord-016938-pk76snuy	16	7	choice	choice	NN
cord-016938-pk76snuy	16	8	for	for	IN
cord-016938-pk76snuy	16	9	transplantation	transplantation	NN
cord-016938-pk76snuy	16	10	since	since	IN
cord-016938-pk76snuy	16	11	several	several	JJ
cord-016938-pk76snuy	16	12	immune	immune	JJ
cord-016938-pk76snuy	16	13	-	-	HYPH
cord-016938-pk76snuy	16	14	suppressive	suppressive	JJ
cord-016938-pk76snuy	16	15	agents	agent	NNS
cord-016938-pk76snuy	16	16	have	have	VBP
cord-016938-pk76snuy	16	17	been	be	VBN
cord-016938-pk76snuy	16	18	introduced	introduce	VBN
cord-016938-pk76snuy	16	19	,	,	,
cord-016938-pk76snuy	16	20	but	but	CC
cord-016938-pk76snuy	16	21	these	these	DT
cord-016938-pk76snuy	16	22	agents	agent	NNS
cord-016938-pk76snuy	16	23	also	also	RB
cord-016938-pk76snuy	16	24	lead	lead	VBP
cord-016938-pk76snuy	16	25	to	to	IN
cord-016938-pk76snuy	16	26	other	other	JJ
cord-016938-pk76snuy	16	27	immune	immune	NN
cord-016938-pk76snuy	16	28	-	-	HYPH
cord-016938-pk76snuy	16	29	depressed	depressed	JJ
cord-016938-pk76snuy	16	30	diseases	disease	NNS
cord-016938-pk76snuy	16	31	by	by	IN
cord-016938-pk76snuy	16	32	breaking	break	VBG
cord-016938-pk76snuy	16	33	the	the	DT
cord-016938-pk76snuy	16	34	natural	natural	JJ
cord-016938-pk76snuy	16	35	immune	immune	JJ
cord-016938-pk76snuy	16	36	homeostasis	homeostasis	NN
cord-016938-pk76snuy	16	37	.	.	.
cord-016938-pk76snuy	17	1	Xenogeneic	Xenogeneic	NNP
cord-016938-pk76snuy	17	2	tissue	tissue	NN
cord-016938-pk76snuy	17	3	and	and	CC
cord-016938-pk76snuy	17	4	organ	organ	NN
cord-016938-pk76snuy	17	5	transplantation	transplantation	NN
cord-016938-pk76snuy	17	6	have	have	VBP
cord-016938-pk76snuy	17	7	been	be	VBN
cord-016938-pk76snuy	17	8	suggested	suggest	VBN
cord-016938-pk76snuy	17	9	by	by	IN
cord-016938-pk76snuy	17	10	a	a	DT
cord-016938-pk76snuy	17	11	number	number	NN
cord-016938-pk76snuy	17	12	of	of	IN
cord-016938-pk76snuy	17	13	researchers	researcher	NNS
cord-016938-pk76snuy	17	14	but	but	CC
cord-016938-pk76snuy	17	15	longevity	longevity	NN
cord-016938-pk76snuy	17	16	difference	difference	NN
cord-016938-pk76snuy	17	17	between	between	IN
cord-016938-pk76snuy	17	18	human	human	JJ
cord-016938-pk76snuy	17	19	and	and	CC
cord-016938-pk76snuy	17	20	donor	donor	NN
cord-016938-pk76snuy	17	21	animal	animal	NN
cord-016938-pk76snuy	17	22	is	be	VBZ
cord-016938-pk76snuy	17	23	a	a	DT
cord-016938-pk76snuy	17	24	great	great	JJ
cord-016938-pk76snuy	17	25	barrier	barrier	NN
cord-016938-pk76snuy	17	26	that	that	WDT
cord-016938-pk76snuy	17	27	can	can	MD
cord-016938-pk76snuy	17	28	not	not	RB
cord-016938-pk76snuy	17	29	be	be	VB
cord-016938-pk76snuy	17	30	overcome	overcome	VBN
cord-016938-pk76snuy	17	31	at	at	IN
cord-016938-pk76snuy	17	32	present	present	NN
cord-016938-pk76snuy	17	33	.	.	.
cord-016938-pk76snuy	18	1	An	an	DT
cord-016938-pk76snuy	18	2	approach	approach	NN
cord-016938-pk76snuy	18	3	to	to	TO
cord-016938-pk76snuy	18	4	treat	treat	VB
cord-016938-pk76snuy	18	5	gene	gene	NN
cord-016938-pk76snuy	18	6	-	-	HYPH
cord-016938-pk76snuy	18	7	defect	defect	NN
cord-016938-pk76snuy	18	8	oriented	orient	VBN
cord-016938-pk76snuy	18	9	congenital	congenital	JJ
cord-016938-pk76snuy	18	10	disease	disease	NN
cord-016938-pk76snuy	18	11	by	by	IN
cord-016938-pk76snuy	18	12	delivering	deliver	VBG
cord-016938-pk76snuy	18	13	correct	correct	JJ
cord-016938-pk76snuy	18	14	genes	gene	NNS
cord-016938-pk76snuy	18	15	directly	directly	RB
cord-016938-pk76snuy	18	16	to	to	IN
cord-016938-pk76snuy	18	17	a	a	DT
cord-016938-pk76snuy	18	18	patient	patient	NN
cord-016938-pk76snuy	18	19	,	,	,
cord-016938-pk76snuy	18	20	known	know	VBN
cord-016938-pk76snuy	18	21	as	as	IN
cord-016938-pk76snuy	18	22	gene	gene	NN
cord-016938-pk76snuy	18	23	therapy	therapy	NN
cord-016938-pk76snuy	18	24	,	,	,
cord-016938-pk76snuy	18	25	has	have	VBZ
cord-016938-pk76snuy	18	26	been	be	VBN
cord-016938-pk76snuy	18	27	introduced	introduce	VBN
cord-016938-pk76snuy	18	28	as	as	IN
cord-016938-pk76snuy	18	29	an	an	DT
cord-016938-pk76snuy	18	30	individualized	individualized	JJ
cord-016938-pk76snuy	18	31	treatment	treatment	NN
cord-016938-pk76snuy	18	32	tool	tool	NN
cord-016938-pk76snuy	18	33	.	.	.
cord-016938-pk76snuy	19	1	Selected	select	VBN
cord-016938-pk76snuy	19	2	genes	gene	NNS
cord-016938-pk76snuy	19	3	hybridized	hybridize	VBN
cord-016938-pk76snuy	19	4	with	with	IN
cord-016938-pk76snuy	19	5	a	a	DT
cord-016938-pk76snuy	19	6	carrier	carrier	NN
cord-016938-pk76snuy	19	7	vector	vector	NN
cord-016938-pk76snuy	19	8	are	be	VBP
cord-016938-pk76snuy	19	9	injected	inject	VBN
cord-016938-pk76snuy	19	10	into	into	IN
cord-016938-pk76snuy	19	11	a	a	DT
cord-016938-pk76snuy	19	12	patient	patient	NN
cord-016938-pk76snuy	19	13	,	,	,
cord-016938-pk76snuy	19	14	and	and	CC
cord-016938-pk76snuy	19	15	the	the	DT
cord-016938-pk76snuy	19	16	vector	vector	NN
cord-016938-pk76snuy	19	17	may	may	MD
cord-016938-pk76snuy	19	18	infect	infect	VB
cord-016938-pk76snuy	19	19	patient	patient	JJ
cord-016938-pk76snuy	19	20	's	's	POS
cord-016938-pk76snuy	19	21	cells	cell	NNS
cord-016938-pk76snuy	19	22	and	and	CC
cord-016938-pk76snuy	19	23	leave	leave	VB
cord-016938-pk76snuy	19	24	the	the	DT
cord-016938-pk76snuy	19	25	selected	select	VBN
cord-016938-pk76snuy	19	26	genes	gene	NNS
cord-016938-pk76snuy	19	27	within	within	IN
cord-016938-pk76snuy	19	28	patient	patient	NN
cord-016938-pk76snuy	19	29	's	's	POS
cord-016938-pk76snuy	19	30	cells	cell	NNS
cord-016938-pk76snuy	19	31	.	.	.
cord-016938-pk76snuy	20	1	Then	then	RB
cord-016938-pk76snuy	20	2	,	,	,
cord-016938-pk76snuy	20	3	the	the	DT
cord-016938-pk76snuy	20	4	delivered	deliver	VBN
cord-016938-pk76snuy	20	5	genes	gene	NNS
cord-016938-pk76snuy	20	6	may	may	MD
cord-016938-pk76snuy	20	7	express	express	VB
cord-016938-pk76snuy	20	8	its	-PRON-	PRP$
cord-016938-pk76snuy	20	9	genetic	genetic	JJ
cord-016938-pk76snuy	20	10	characteristics	characteristic	NNS
cord-016938-pk76snuy	20	11	necessary	necessary	JJ
cord-016938-pk76snuy	20	12	to	to	TO
cord-016938-pk76snuy	20	13	cure	cure	VB
cord-016938-pk76snuy	20	14	the	the	DT
cord-016938-pk76snuy	20	15	disease	disease	NN
cord-016938-pk76snuy	20	16	.	.	.
cord-016938-pk76snuy	21	1	However	however	RB
cord-016938-pk76snuy	21	2	,	,	,
cord-016938-pk76snuy	21	3	the	the	DT
cord-016938-pk76snuy	21	4	gene	gene	NN
cord-016938-pk76snuy	21	5	therapy	therapy	NN
cord-016938-pk76snuy	21	6	bears	bear	VBZ
cord-016938-pk76snuy	21	7	several	several	JJ
cord-016938-pk76snuy	21	8	problems	problem	NNS
cord-016938-pk76snuy	21	9	:	:	:
cord-016938-pk76snuy	22	1	(	(	-LRB-
cord-016938-pk76snuy	22	2	1	1	LS
cord-016938-pk76snuy	22	3	)	)	-RRB-
cord-016938-pk76snuy	22	4	there	there	EX
cord-016938-pk76snuy	22	5	is	be	VBZ
cord-016938-pk76snuy	22	6	no	no	DT
cord-016938-pk76snuy	22	7	perfect	perfect	JJ
cord-016938-pk76snuy	22	8	method	method	NN
cord-016938-pk76snuy	22	9	to	to	TO
cord-016938-pk76snuy	22	10	deliver	deliver	VB
cord-016938-pk76snuy	22	11	genes	gene	NNS
cord-016938-pk76snuy	22	12	into	into	IN
cord-016938-pk76snuy	22	13	appropriate	appropriate	JJ
cord-016938-pk76snuy	22	14	cells	cell	NNS
cord-016938-pk76snuy	22	15	,	,	,
cord-016938-pk76snuy	22	16	(	(	-LRB-
cord-016938-pk76snuy	22	17	2	2	LS
cord-016938-pk76snuy	22	18	)	)	-RRB-
cord-016938-pk76snuy	22	19	efficiency	efficiency	NN
cord-016938-pk76snuy	22	20	of	of	IN
cord-016938-pk76snuy	22	21	gene	gene	NN
cord-016938-pk76snuy	22	22	expression	expression	NN
cord-016938-pk76snuy	22	23	varies	vary	VBZ
cord-016938-pk76snuy	22	24	,	,	,
cord-016938-pk76snuy	22	25	and	and	CC
cord-016938-pk76snuy	22	26	(	(	-LRB-
cord-016938-pk76snuy	22	27	3	3	LS
cord-016938-pk76snuy	22	28	)	)	-RRB-
cord-016938-pk76snuy	22	29	the	the	DT
cord-016938-pk76snuy	22	30	gene	gene	NN
cord-016938-pk76snuy	22	31	delivering	deliver	VBG
cord-016938-pk76snuy	22	32	viral	viral	JJ
cord-016938-pk76snuy	22	33	vector	vector	NN
cord-016938-pk76snuy	22	34	may	may	MD
cord-016938-pk76snuy	22	35	induce	induce	VB
cord-016938-pk76snuy	22	36	unpredictable	unpredictable	JJ
cord-016938-pk76snuy	22	37	and	and	CC
cord-016938-pk76snuy	22	38	unknown	unknown	JJ
cord-016938-pk76snuy	22	39	complications	complication	NNS
cord-016938-pk76snuy	22	40	in	in	IN
cord-016938-pk76snuy	22	41	body	body	NN
cord-016938-pk76snuy	22	42	.	.	.
cord-016938-pk76snuy	23	1	Another	another	DT
cord-016938-pk76snuy	23	2	individualize	individualize	NN
cord-016938-pk76snuy	23	3	treatment	treatment	NN
cord-016938-pk76snuy	23	4	tool	tool	NN
cord-016938-pk76snuy	23	5	called	call	VBN
cord-016938-pk76snuy	23	6	cell	cell	NN
cord-016938-pk76snuy	23	7	therapy	therapy	NN
cord-016938-pk76snuy	23	8	is	be	VBZ
cord-016938-pk76snuy	23	9	planting	plant	VBG
cord-016938-pk76snuy	23	10	therapeutic	therapeutic	JJ
cord-016938-pk76snuy	23	11	cells	cell	NNS
cord-016938-pk76snuy	23	12	.	.	.
cord-016938-pk76snuy	24	1	Instead	instead	RB
cord-016938-pk76snuy	24	2	of	of	IN
cord-016938-pk76snuy	24	3	transplanting	transplant	VBG
cord-016938-pk76snuy	24	4	tissue	tissue	NN
cord-016938-pk76snuy	24	5	or	or	CC
cord-016938-pk76snuy	24	6	organ	organ	NN
cord-016938-pk76snuy	24	7	,	,	,
cord-016938-pk76snuy	24	8	therapeutic	therapeutic	JJ
cord-016938-pk76snuy	24	9	cells	cell	NNS
cord-016938-pk76snuy	24	10	are	be	VBP
cord-016938-pk76snuy	24	11	delivered	deliver	VBN
cord-016938-pk76snuy	24	12	in	in	IN
cord-016938-pk76snuy	24	13	forms	form	NNS
cord-016938-pk76snuy	24	14	of	of	IN
cord-016938-pk76snuy	24	15	either	either	DT
cord-016938-pk76snuy	24	16	transplantation	transplantation	NN
cord-016938-pk76snuy	24	17	of	of	IN
cord-016938-pk76snuy	24	18	natural	natural	JJ
cord-016938-pk76snuy	24	19	cells	cell	NNS
cord-016938-pk76snuy	24	20	or	or	CC
cord-016938-pk76snuy	24	21	implantation	implantation	NN
cord-016938-pk76snuy	24	22	of	of	IN
cord-016938-pk76snuy	24	23	artificially	artificially	RB
cord-016938-pk76snuy	24	24	manipulated	manipulate	VBN
cord-016938-pk76snuy	24	25	cells	cell	NNS
cord-016938-pk76snuy	24	26	.	.	.
cord-016938-pk76snuy	25	1	In	in	IN
cord-016938-pk76snuy	25	2	addition	addition	NN
cord-016938-pk76snuy	25	3	,	,	,
cord-016938-pk76snuy	25	4	resource	resource	NN
cord-016938-pk76snuy	25	5	of	of	IN
cord-016938-pk76snuy	25	6	applicable	applicable	JJ
cord-016938-pk76snuy	25	7	tissues	tissue	NNS
cord-016938-pk76snuy	25	8	from	from	IN
cord-016938-pk76snuy	25	9	which	which	WDT
cord-016938-pk76snuy	25	10	therapeutic	therapeutic	JJ
cord-016938-pk76snuy	25	11	cells	cell	NNS
cord-016938-pk76snuy	25	12	could	could	MD
cord-016938-pk76snuy	25	13	be	be	VB
cord-016938-pk76snuy	25	14	prepared	prepare	VBN
cord-016938-pk76snuy	25	15	is	be	VBZ
cord-016938-pk76snuy	25	16	expanded	expand	VBN
cord-016938-pk76snuy	25	17	.	.	.
cord-016938-pk76snuy	26	1	Conventional	conventional	JJ
cord-016938-pk76snuy	26	2	transplantation	transplantation	NN
cord-016938-pk76snuy	26	3	mainly	mainly	RB
cord-016938-pk76snuy	26	4	consists	consist	VBZ
cord-016938-pk76snuy	26	5	of	of	IN
cord-016938-pk76snuy	26	6	matured	mature	VBN
cord-016938-pk76snuy	26	7	tissue	tissue	NN
cord-016938-pk76snuy	26	8	or	or	CC
cord-016938-pk76snuy	26	9	organ	organ	NN
cord-016938-pk76snuy	26	10	,	,	,
cord-016938-pk76snuy	26	11	but	but	CC
cord-016938-pk76snuy	26	12	it	-PRON-	PRP
cord-016938-pk76snuy	26	13	is	be	VBZ
cord-016938-pk76snuy	26	14	now	now	RB
cord-016938-pk76snuy	26	15	possible	possible	JJ
cord-016938-pk76snuy	26	16	to	to	TO
cord-016938-pk76snuy	26	17	obtain	obtain	VB
cord-016938-pk76snuy	26	18	therapeutic	therapeutic	JJ
cord-016938-pk76snuy	26	19	cells	cell	NNS
cord-016938-pk76snuy	26	20	from	from	IN
cord-016938-pk76snuy	26	21	any	any	DT
cord-016938-pk76snuy	26	22	tissue	tissue	NN
cord-016938-pk76snuy	26	23	at	at	IN
cord-016938-pk76snuy	26	24	any	any	DT
cord-016938-pk76snuy	26	25	growth	growth	NN
cord-016938-pk76snuy	26	26	stage	stage	NN
cord-016938-pk76snuy	26	27	,	,	,
cord-016938-pk76snuy	26	28	including	include	VBG
cord-016938-pk76snuy	26	29	embryonic	embryonic	JJ
cord-016938-pk76snuy	26	30	blastocyst	blastocyst	NN
cord-016938-pk76snuy	26	31	.	.	.
cord-016938-pk76snuy	27	1	Through	through	IN
cord-016938-pk76snuy	27	2	in	in	IN
cord-016938-pk76snuy	27	3	vitro	vitro	FW
cord-016938-pk76snuy	27	4	gene	gene	NN
cord-016938-pk76snuy	27	5	modification	modification	NN
cord-016938-pk76snuy	27	6	of	of	IN
cord-016938-pk76snuy	27	7	cells	cell	NNS
cord-016938-pk76snuy	27	8	,	,	,
cord-016938-pk76snuy	27	9	it	-PRON-	PRP
cord-016938-pk76snuy	27	10	is	be	VBZ
cord-016938-pk76snuy	27	11	possible	possible	JJ
cord-016938-pk76snuy	27	12	to	to	TO
cord-016938-pk76snuy	27	13	select	select	VB
cord-016938-pk76snuy	27	14	only	only	RB
cord-016938-pk76snuy	27	15	the	the	DT
cord-016938-pk76snuy	27	16	cells	cell	NNS
cord-016938-pk76snuy	27	17	which	which	WDT
cord-016938-pk76snuy	27	18	possess	possess	VBP
cord-016938-pk76snuy	27	19	appropriate	appropriate	JJ
cord-016938-pk76snuy	27	20	genes	gene	NNS
cord-016938-pk76snuy	27	21	for	for	IN
cord-016938-pk76snuy	27	22	treatment	treatment	NN
cord-016938-pk76snuy	27	23	purposes	purpose	NNS
cord-016938-pk76snuy	27	24	from	from	IN
cord-016938-pk76snuy	27	25	outside	outside	IN
cord-016938-pk76snuy	27	26	of	of	IN
cord-016938-pk76snuy	27	27	the	the	DT
cord-016938-pk76snuy	27	28	human	human	JJ
cord-016938-pk76snuy	27	29	body	body	NN
cord-016938-pk76snuy	27	30	.	.	.
cord-016938-pk76snuy	28	1	Theoretically	theoretically	RB
cord-016938-pk76snuy	28	2	,	,	,
cord-016938-pk76snuy	28	3	in	in	IN
cord-016938-pk76snuy	28	4	case	case	NN
cord-016938-pk76snuy	28	5	of	of	IN
cord-016938-pk76snuy	28	6	autologous	autologous	JJ
cord-016938-pk76snuy	28	7	cell	cell	NN
cord-016938-pk76snuy	28	8	therapy	therapy	NN
cord-016938-pk76snuy	28	9	,	,	,
cord-016938-pk76snuy	28	10	patient	patient	NN
cord-016938-pk76snuy	28	11	's	's	POS
cord-016938-pk76snuy	28	12	cells	cell	NNS
cord-016938-pk76snuy	28	13	are	be	VBP
cord-016938-pk76snuy	28	14	harvested	harvest	VBN
cord-016938-pk76snuy	28	15	through	through	IN
cord-016938-pk76snuy	28	16	autopsy	autopsy	JJ
cord-016938-pk76snuy	28	17	or	or	CC
cord-016938-pk76snuy	28	18	procurement	procurement	NN
cord-016938-pk76snuy	28	19	,	,	,
cord-016938-pk76snuy	28	20	and	and	CC
cord-016938-pk76snuy	28	21	the	the	DT
cord-016938-pk76snuy	28	22	treatment	treatment	NN
cord-016938-pk76snuy	28	23	gene	gene	NN
cord-016938-pk76snuy	28	24	for	for	IN
cord-016938-pk76snuy	28	25	correction	correction	NN
cord-016938-pk76snuy	28	26	is	be	VBZ
cord-016938-pk76snuy	28	27	transfected	transfecte	VBN
cord-016938-pk76snuy	28	28	into	into	IN
cord-016938-pk76snuy	28	29	the	the	DT
cord-016938-pk76snuy	28	30	cells	cell	NNS
cord-016938-pk76snuy	28	31	.	.	.
cord-016938-pk76snuy	29	1	After	after	IN
cord-016938-pk76snuy	29	2	culture	culture	NN
cord-016938-pk76snuy	29	3	,	,	,
cord-016938-pk76snuy	29	4	only	only	RB
cord-016938-pk76snuy	29	5	the	the	DT
cord-016938-pk76snuy	29	6	completely	completely	RB
cord-016938-pk76snuy	29	7	gene	gene	NN
cord-016938-pk76snuy	29	8	-	-	HYPH
cord-016938-pk76snuy	29	9	transfected	transfecte	VBN
cord-016938-pk76snuy	29	10	,	,	,
cord-016938-pk76snuy	29	11	healthy	healthy	JJ
cord-016938-pk76snuy	29	12	cells	cell	NNS
cord-016938-pk76snuy	29	13	are	be	VBP
cord-016938-pk76snuy	29	14	collected	collect	VBN
cord-016938-pk76snuy	29	15	,	,	,
cord-016938-pk76snuy	29	16	and	and	CC
cord-016938-pk76snuy	29	17	the	the	DT
cord-016938-pk76snuy	29	18	selected	select	VBN
cord-016938-pk76snuy	29	19	cells	cell	NNS
cord-016938-pk76snuy	29	20	are	be	VBP
cord-016938-pk76snuy	29	21	further	further	RB
cord-016938-pk76snuy	29	22	cultured	culture	VBN
cord-016938-pk76snuy	29	23	to	to	TO
cord-016938-pk76snuy	29	24	obtain	obtain	VB
cord-016938-pk76snuy	29	25	abundant	abundant	JJ
cord-016938-pk76snuy	29	26	number	number	NN
cord-016938-pk76snuy	29	27	of	of	IN
cord-016938-pk76snuy	29	28	cells	cell	NNS
cord-016938-pk76snuy	29	29	to	to	TO
cord-016938-pk76snuy	29	30	deliver	deliver	VB
cord-016938-pk76snuy	29	31	in	in	IN
cord-016938-pk76snuy	29	32	forms	form	NNS
cord-016938-pk76snuy	29	33	of	of	IN
cord-016938-pk76snuy	29	34	cell	cell	NN
cord-016938-pk76snuy	29	35	suspension	suspension	NN
cord-016938-pk76snuy	29	36	for	for	IN
cord-016938-pk76snuy	29	37	injection	injection	NN
cord-016938-pk76snuy	29	38	.	.	.
cord-016938-pk76snuy	30	1	As	as	IN
cord-016938-pk76snuy	30	2	the	the	DT
cord-016938-pk76snuy	30	3	whole	whole	JJ
cord-016938-pk76snuy	30	4	procedure	procedure	NN
cord-016938-pk76snuy	30	5	is	be	VBZ
cord-016938-pk76snuy	30	6	performed	perform	VBN
cord-016938-pk76snuy	30	7	in	in	IN
cord-016938-pk76snuy	30	8	vitro	vitro	FW
cord-016938-pk76snuy	30	9	environment	environment	NN
cord-016938-pk76snuy	30	10	,	,	,
cord-016938-pk76snuy	30	11	only	only	RB
cord-016938-pk76snuy	30	12	perfectly	perfectly	RB
cord-016938-pk76snuy	30	13	modified	modify	VBN
cord-016938-pk76snuy	30	14	therapeutic	therapeutic	JJ
cord-016938-pk76snuy	30	15	cells	cell	NNS
cord-016938-pk76snuy	30	16	are	be	VBP
cord-016938-pk76snuy	30	17	selected	select	VBN
cord-016938-pk76snuy	30	18	.	.	.
cord-016938-pk76snuy	31	1	In	in	IN
cord-016938-pk76snuy	31	2	case	case	NN
cord-016938-pk76snuy	31	3	of	of	IN
cord-016938-pk76snuy	31	4	allogeneic	allogeneic	NN
cord-016938-pk76snuy	31	5	cell	cell	NN
cord-016938-pk76snuy	31	6	therapy	therapy	NN
cord-016938-pk76snuy	31	7	,	,	,
cord-016938-pk76snuy	31	8	donor	donor	NN
cord-016938-pk76snuy	31	9	's	's	POS
cord-016938-pk76snuy	31	10	HLA	HLA	NNP
cord-016938-pk76snuy	31	11	could	could	MD
cord-016938-pk76snuy	31	12	be	be	VB
cord-016938-pk76snuy	31	13	also	also	RB
cord-016938-pk76snuy	31	14	replaced	replace	VBN
cord-016938-pk76snuy	31	15	by	by	IN
cord-016938-pk76snuy	31	16	the	the	DT
cord-016938-pk76snuy	31	17	recipient	recipient	NN
cord-016938-pk76snuy	31	18	's	's	POS
cord-016938-pk76snuy	31	19	to	to	TO
cord-016938-pk76snuy	31	20	escape	escape	VB
cord-016938-pk76snuy	31	21	from	from	IN
cord-016938-pk76snuy	31	22	the	the	DT
cord-016938-pk76snuy	31	23	post	post	JJ
cord-016938-pk76snuy	31	24	-	-	JJ
cord-016938-pk76snuy	31	25	operative	operative	JJ
cord-016938-pk76snuy	31	26	immune	immune	JJ
cord-016938-pk76snuy	31	27	rejection	rejection	NN
cord-016938-pk76snuy	31	28	.	.	.
cord-016938-pk76snuy	32	1	Furthermore	furthermore	RB
cord-016938-pk76snuy	32	2	,	,	,
cord-016938-pk76snuy	32	3	risk	risk	NN
cord-016938-pk76snuy	32	4	of	of	IN
cord-016938-pk76snuy	32	5	inducing	induce	VBG
cord-016938-pk76snuy	32	6	uncontrollable	uncontrollable	JJ
cord-016938-pk76snuy	32	7	oncogenesis	oncogenesis	NN
cord-016938-pk76snuy	32	8	oriented	orient	VBN
cord-016938-pk76snuy	32	9	from	from	IN
cord-016938-pk76snuy	32	10	the	the	DT
cord-016938-pk76snuy	32	11	mutated	mutate	VBN
cord-016938-pk76snuy	32	12	cells	cell	NNS
cord-016938-pk76snuy	32	13	is	be	VBZ
cord-016938-pk76snuy	32	14	avoidable	avoidable	JJ
cord-016938-pk76snuy	32	15	during	during	IN
cord-016938-pk76snuy	32	16	the	the	DT
cord-016938-pk76snuy	32	17	cell	cell	NN
cord-016938-pk76snuy	32	18	selecting	select	VBG
cord-016938-pk76snuy	32	19	procedure	procedure	NN
cord-016938-pk76snuy	32	20	in	in	IN
cord-016938-pk76snuy	32	21	vitro	vitro	FW
cord-016938-pk76snuy	32	22	[	[	-LRB-
cord-016938-pk76snuy	32	23	1	1	CD
cord-016938-pk76snuy	32	24	]	]	-RRB-
cord-016938-pk76snuy	32	25	.	.	.
cord-016938-pk76snuy	33	1	To	to	TO
cord-016938-pk76snuy	33	2	deliver	deliver	VB
cord-016938-pk76snuy	33	3	the	the	DT
cord-016938-pk76snuy	33	4	selected	select	VBN
cord-016938-pk76snuy	33	5	cells	cell	NNS
cord-016938-pk76snuy	33	6	into	into	IN
cord-016938-pk76snuy	33	7	the	the	DT
cord-016938-pk76snuy	33	8	selected	select	VBN
cord-016938-pk76snuy	33	9	site	site	NN
cord-016938-pk76snuy	33	10	in	in	IN
cord-016938-pk76snuy	33	11	recipient	recipient	NN
cord-016938-pk76snuy	33	12	's	's	POS
cord-016938-pk76snuy	33	13	body	body	NN
cord-016938-pk76snuy	33	14	,	,	,
cord-016938-pk76snuy	33	15	it	-PRON-	PRP
cord-016938-pk76snuy	33	16	is	be	VBZ
cord-016938-pk76snuy	33	17	necessary	necessary	JJ
cord-016938-pk76snuy	33	18	to	to	TO
cord-016938-pk76snuy	33	19	fabricate	fabricate	VB
cord-016938-pk76snuy	33	20	cell	cell	NN
cord-016938-pk76snuy	33	21	delivery	delivery	NN
cord-016938-pk76snuy	33	22	vehicle	vehicle	NN
cord-016938-pk76snuy	33	23	with	with	IN
cord-016938-pk76snuy	33	24	biomaterials	biomaterial	NNS
cord-016938-pk76snuy	33	25	that	that	WDT
cord-016938-pk76snuy	33	26	supply	supply	VBP
cord-016938-pk76snuy	33	27	agents	agent	NNS
cord-016938-pk76snuy	33	28	to	to	TO
cord-016938-pk76snuy	33	29	maintain	maintain	VB
cord-016938-pk76snuy	33	30	cell	cell	NN
cord-016938-pk76snuy	33	31	-	-	HYPH
cord-016938-pk76snuy	33	32	viability	viability	NN
cord-016938-pk76snuy	33	33	and	and	CC
cord-016938-pk76snuy	33	34	act	act	NN
cord-016938-pk76snuy	33	35	as	as	IN
cord-016938-pk76snuy	33	36	probes	probe	NNS
cord-016938-pk76snuy	33	37	for	for	IN
cord-016938-pk76snuy	33	38	piloting	pilot	VBG
cord-016938-pk76snuy	33	39	cells	cell	NNS
cord-016938-pk76snuy	33	40	toward	toward	IN
cord-016938-pk76snuy	33	41	appropriate	appropriate	JJ
cord-016938-pk76snuy	33	42	site	site	NN
cord-016938-pk76snuy	33	43	.	.	.
cord-016938-pk76snuy	34	1	The	the	DT
cord-016938-pk76snuy	34	2	cell	cell	NN
cord-016938-pk76snuy	34	3	-	-	HYPH
cord-016938-pk76snuy	34	4	based	base	VBN
cord-016938-pk76snuy	34	5	implant	implant	NN
cord-016938-pk76snuy	34	6	is	be	VBZ
cord-016938-pk76snuy	34	7	defined	define	VBN
cord-016938-pk76snuy	34	8	as	as	IN
cord-016938-pk76snuy	34	9	any	any	DT
cord-016938-pk76snuy	34	10	implant	implant	NN
cord-016938-pk76snuy	34	11	in	in	IN
cord-016938-pk76snuy	34	12	combination	combination	NN
cord-016938-pk76snuy	34	13	of	of	IN
cord-016938-pk76snuy	34	14	cells	cell	NNS
cord-016938-pk76snuy	34	15	and	and	CC
cord-016938-pk76snuy	34	16	biomaterials	biomaterial	NNS
cord-016938-pk76snuy	34	17	which	which	WDT
cord-016938-pk76snuy	34	18	are	be	VBP
cord-016938-pk76snuy	34	19	intended	intend	VBN
cord-016938-pk76snuy	34	20	to	to	TO
cord-016938-pk76snuy	34	21	repair	repair	VB
cord-016938-pk76snuy	34	22	,	,	,
cord-016938-pk76snuy	34	23	modify	modify	VB
cord-016938-pk76snuy	34	24	and/or	and/or	CC
cord-016938-pk76snuy	34	25	regenerate	regenerate	VB
cord-016938-pk76snuy	34	26	human	human	JJ
cord-016938-pk76snuy	34	27	body	body	NN
cord-016938-pk76snuy	34	28	,	,	,
cord-016938-pk76snuy	34	29	through	through	IN
cord-016938-pk76snuy	34	30	expected	expect	VBN
cord-016938-pk76snuy	34	31	regulation	regulation	NN
cord-016938-pk76snuy	34	32	and	and	CC
cord-016938-pk76snuy	34	33	control	control	NN
cord-016938-pk76snuy	34	34	of	of	IN
cord-016938-pk76snuy	34	35	cellular	cellular	JJ
cord-016938-pk76snuy	34	36	functions	function	NNS
cord-016938-pk76snuy	34	37	and/or	and/or	CC
cord-016938-pk76snuy	34	38	behaviors	behavior	NNS
cord-016938-pk76snuy	34	39	after	after	IN
cord-016938-pk76snuy	34	40	implantation	implantation	NN
cord-016938-pk76snuy	34	41	.	.	.
cord-016938-pk76snuy	35	1	The	the	DT
cord-016938-pk76snuy	35	2	cell	cell	NN
cord-016938-pk76snuy	35	3	-	-	HYPH
cord-016938-pk76snuy	35	4	based	base	VBN
cord-016938-pk76snuy	35	5	implant	implant	NN
cord-016938-pk76snuy	35	6	consists	consist	VBZ
cord-016938-pk76snuy	35	7	of	of	IN
cord-016938-pk76snuy	35	8	artificially	artificially	RB
cord-016938-pk76snuy	35	9	manipulated	manipulate	VBN
cord-016938-pk76snuy	35	10	therapeutic	therapeutic	JJ
cord-016938-pk76snuy	35	11	cells	cell	NNS
cord-016938-pk76snuy	35	12	hybridized	hybridize	VBN
cord-016938-pk76snuy	35	13	with	with	IN
cord-016938-pk76snuy	35	14	biomaterials	biomaterial	NNS
cord-016938-pk76snuy	35	15	in	in	IN
cord-016938-pk76snuy	35	16	vitro	vitro	FW
cord-016938-pk76snuy	35	17	.	.	.
cord-016938-pk76snuy	36	1	For	for	IN
cord-016938-pk76snuy	36	2	cell	cell	NN
cord-016938-pk76snuy	36	3	therapy	therapy	NN
cord-016938-pk76snuy	36	4	,	,	,
cord-016938-pk76snuy	36	5	each	each	DT
cord-016938-pk76snuy	36	6	cell	cell	NN
cord-016938-pk76snuy	36	7	is	be	VBZ
cord-016938-pk76snuy	36	8	individually	individually	RB
cord-016938-pk76snuy	36	9	hybridized	hybridize	VBN
cord-016938-pk76snuy	36	10	with	with	IN
cord-016938-pk76snuy	36	11	biomaterials	biomaterial	NNS
cord-016938-pk76snuy	36	12	,	,	,
cord-016938-pk76snuy	36	13	but	but	CC
cord-016938-pk76snuy	36	14	in	in	IN
cord-016938-pk76snuy	36	15	forms	form	NNS
cord-016938-pk76snuy	36	16	of	of	IN
cord-016938-pk76snuy	36	17	tissue	tissue	NN
cord-016938-pk76snuy	36	18	engineered	engineer	VBN
cord-016938-pk76snuy	36	19	implants	implant	NNS
cord-016938-pk76snuy	36	20	,	,	,
cord-016938-pk76snuy	36	21	cells	cell	NNS
cord-016938-pk76snuy	36	22	are	be	VBP
cord-016938-pk76snuy	36	23	hybridized	hybridize	VBN
cord-016938-pk76snuy	36	24	with	with	IN
cord-016938-pk76snuy	36	25	scaffold	scaffold	NN
cord-016938-pk76snuy	36	26	-	-	HYPH
cord-016938-pk76snuy	36	27	biomaterials	biomaterial	NNS
cord-016938-pk76snuy	36	28	that	that	WDT
cord-016938-pk76snuy	36	29	act	act	VBP
cord-016938-pk76snuy	36	30	as	as	IN
cord-016938-pk76snuy	36	31	structural	structural	JJ
cord-016938-pk76snuy	36	32	support	support	NN
cord-016938-pk76snuy	36	33	in	in	IN
cord-016938-pk76snuy	36	34	the	the	DT
cord-016938-pk76snuy	36	35	same	same	JJ
cord-016938-pk76snuy	36	36	way	way	NN
cord-016938-pk76snuy	36	37	as	as	IN
cord-016938-pk76snuy	36	38	the	the	DT
cord-016938-pk76snuy	36	39	extracellular	extracellular	JJ
cord-016938-pk76snuy	36	40	matrix	matrix	NN
cord-016938-pk76snuy	36	41	in	in	IN
cord-016938-pk76snuy	36	42	tissue	tissue	NN
cord-016938-pk76snuy	36	43	does	do	VBZ
cord-016938-pk76snuy	36	44	[	[	-LRB-
cord-016938-pk76snuy	36	45	2	2	LS
cord-016938-pk76snuy	36	46	]	]	-RRB-
cord-016938-pk76snuy	36	47	(	(	-LRB-
cord-016938-pk76snuy	37	1	Fig	Fig	NNP
cord-016938-pk76snuy	37	2	.	.	.
cord-016938-pk76snuy	37	3	8.1	8.1	CD
cord-016938-pk76snuy	37	4	)	)	-RRB-
cord-016938-pk76snuy	37	5	.	.	.
cord-016938-pk76snuy	38	1	Substances	substance	NNS
cord-016938-pk76snuy	38	2	applied	apply	VBD
cord-016938-pk76snuy	38	3	to	to	TO
cord-016938-pk76snuy	38	4	control	control	VB
cord-016938-pk76snuy	38	5	biological	biological	JJ
cord-016938-pk76snuy	38	6	events	event	NNS
cord-016938-pk76snuy	38	7	of	of	IN
cord-016938-pk76snuy	38	8	cells	cell	NNS
cord-016938-pk76snuy	38	9	may	may	MD
cord-016938-pk76snuy	38	10	have	have	VB
cord-016938-pk76snuy	38	11	biological	biological	JJ
cord-016938-pk76snuy	38	12	risks	risk	NNS
cord-016938-pk76snuy	38	13	.	.	.
cord-016938-pk76snuy	39	1	In	in	IN
cord-016938-pk76snuy	39	2	manipulating	manipulate	VBG
cord-016938-pk76snuy	39	3	cells	cell	NNS
cord-016938-pk76snuy	39	4	,	,	,
cord-016938-pk76snuy	39	5	various	various	JJ
cord-016938-pk76snuy	39	6	kinds	kind	NNS
cord-016938-pk76snuy	39	7	of	of	IN
cord-016938-pk76snuy	39	8	substances	substance	NNS
cord-016938-pk76snuy	39	9	functioning	function	VBG
cord-016938-pk76snuy	39	10	chemically	chemically	RB
cord-016938-pk76snuy	39	11	at	at	IN
cord-016938-pk76snuy	39	12	molecular	molecular	JJ
cord-016938-pk76snuy	39	13	level	level	NN
cord-016938-pk76snuy	39	14	are	be	VBP
cord-016938-pk76snuy	39	15	used	use	VBN
cord-016938-pk76snuy	39	16	in	in	IN
cord-016938-pk76snuy	39	17	cell	cell	NN
cord-016938-pk76snuy	39	18	-	-	HYPH
cord-016938-pk76snuy	39	19	modifying	modify	VBG
cord-016938-pk76snuy	39	20	procedures	procedure	NNS
cord-016938-pk76snuy	39	21	.	.	.
cord-016938-pk76snuy	40	1	Biological	biological	JJ
cord-016938-pk76snuy	40	2	agents	agent	NNS
cord-016938-pk76snuy	40	3	,	,	,
cord-016938-pk76snuy	40	4	such	such	JJ
cord-016938-pk76snuy	40	5	as	as	IN
cord-016938-pk76snuy	40	6	enzymes	enzyme	NNS
cord-016938-pk76snuy	40	7	in	in	IN
cord-016938-pk76snuy	40	8	the	the	DT
cord-016938-pk76snuy	40	9	nucleic	nucleic	JJ
cord-016938-pk76snuy	40	10	acid	acid	NN
cord-016938-pk76snuy	40	11	recombination	recombination	NN
cord-016938-pk76snuy	40	12	procedure	procedure	NN
cord-016938-pk76snuy	40	13	,	,	,
cord-016938-pk76snuy	40	14	cytokines	cytokine	NNS
cord-016938-pk76snuy	40	15	in	in	IN
cord-016938-pk76snuy	40	16	cell	cell	NN
cord-016938-pk76snuy	40	17	differentiation	differentiation	NN
cord-016938-pk76snuy	40	18	and	and	CC
cord-016938-pk76snuy	40	19	proliferation	proliferation	NN
cord-016938-pk76snuy	40	20	control	control	NN
cord-016938-pk76snuy	40	21	,	,	,
cord-016938-pk76snuy	40	22	and	and	CC
cord-016938-pk76snuy	40	23	peptides	peptide	NNS
cord-016938-pk76snuy	40	24	in	in	IN
cord-016938-pk76snuy	40	25	cell	cell	NN
cord-016938-pk76snuy	40	26	culture	culture	NN
cord-016938-pk76snuy	40	27	media	medium	NNS
cord-016938-pk76snuy	40	28	,	,	,
cord-016938-pk76snuy	40	29	are	be	VBP
cord-016938-pk76snuy	40	30	regarded	regard	VBN
cord-016938-pk76snuy	40	31	as	as	IN
cord-016938-pk76snuy	40	32	biologic	biologic	JJ
cord-016938-pk76snuy	40	33	substances	substance	NNS
cord-016938-pk76snuy	40	34	,	,	,
cord-016938-pk76snuy	40	35	and	and	CC
cord-016938-pk76snuy	40	36	they	-PRON-	PRP
cord-016938-pk76snuy	40	37	must	must	MD
cord-016938-pk76snuy	40	38	not	not	RB
cord-016938-pk76snuy	40	39	produce	produce	VB
cord-016938-pk76snuy	40	40	any	any	DT
cord-016938-pk76snuy	40	41	biological	biological	JJ
cord-016938-pk76snuy	40	42	hazard	hazard	NN
cord-016938-pk76snuy	40	43	during	during	IN
cord-016938-pk76snuy	40	44	the	the	DT
cord-016938-pk76snuy	40	45	manipulation	manipulation	NN
cord-016938-pk76snuy	40	46	procedures	procedure	NNS
cord-016938-pk76snuy	40	47	.	.	.
cord-016938-pk76snuy	41	1	In	in	IN
cord-016938-pk76snuy	41	2	gene	gene	NN
cord-016938-pk76snuy	41	3	modification	modification	NN
cord-016938-pk76snuy	41	4	process	process	NN
cord-016938-pk76snuy	41	5	,	,	,
cord-016938-pk76snuy	41	6	to	to	TO
cord-016938-pk76snuy	41	7	avoid	avoid	VB
cord-016938-pk76snuy	41	8	adverse	adverse	JJ
cord-016938-pk76snuy	41	9	reactions	reaction	NNS
cord-016938-pk76snuy	41	10	oriented	orient	VBN
cord-016938-pk76snuy	41	11	from	from	IN
cord-016938-pk76snuy	41	12	viral	viral	JJ
cord-016938-pk76snuy	41	13	vectors	vector	NNS
cord-016938-pk76snuy	41	14	,	,	,
cord-016938-pk76snuy	41	15	such	such	JJ
cord-016938-pk76snuy	41	16	as	as	IN
cord-016938-pk76snuy	41	17	retrovirus	retrovirus	NN
cord-016938-pk76snuy	41	18	,	,	,
cord-016938-pk76snuy	41	19	adenovirus	adenovirus	NN
cord-016938-pk76snuy	41	20	and	and	CC
cord-016938-pk76snuy	41	21	adeno	adeno	NN
cord-016938-pk76snuy	41	22	-	-	HYPH
cord-016938-pk76snuy	41	23	associate	associate	JJ
cord-016938-pk76snuy	41	24	virus	virus	NN
cord-016938-pk76snuy	41	25	,	,	,
cord-016938-pk76snuy	41	26	non	non	JJ
cord-016938-pk76snuy	41	27	-	-	JJ
cord-016938-pk76snuy	41	28	viral	viral	JJ
cord-016938-pk76snuy	41	29	vectors	vector	NNS
cord-016938-pk76snuy	41	30	are	be	VBP
cord-016938-pk76snuy	41	31	designed	design	VBN
cord-016938-pk76snuy	41	32	to	to	TO
cord-016938-pk76snuy	41	33	avoid	avoid	VB
cord-016938-pk76snuy	41	34	biological	biological	JJ
cord-016938-pk76snuy	41	35	risks	risk	NNS
cord-016938-pk76snuy	41	36	and	and	CC
cord-016938-pk76snuy	41	37	to	to	TO
cord-016938-pk76snuy	41	38	manipulate	manipulate	VB
cord-016938-pk76snuy	41	39	easily	easily	RB
cord-016938-pk76snuy	41	40	.	.	.
cord-016938-pk76snuy	42	1	Capability	capability	NN
cord-016938-pk76snuy	42	2	of	of	IN
cord-016938-pk76snuy	42	3	non	non	JJ
cord-016938-pk76snuy	42	4	-	-	JJ
cord-016938-pk76snuy	42	5	viral	viral	JJ
cord-016938-pk76snuy	42	6	vectors	vector	NNS
cord-016938-pk76snuy	42	7	is	be	VBZ
cord-016938-pk76snuy	42	8	mainly	mainly	RB
cord-016938-pk76snuy	42	9	dependent	dependent	JJ
cord-016938-pk76snuy	42	10	on	on	IN
cord-016938-pk76snuy	42	11	endocytosis	endocytosis	NN
cord-016938-pk76snuy	42	12	mechanism	mechanism	NN
cord-016938-pk76snuy	42	13	,	,	,
cord-016938-pk76snuy	42	14	but	but	CC
cord-016938-pk76snuy	42	15	the	the	DT
cord-016938-pk76snuy	42	16	extent	extent	NN
cord-016938-pk76snuy	42	17	of	of	IN
cord-016938-pk76snuy	42	18	development	development	NN
cord-016938-pk76snuy	42	19	in	in	IN
cord-016938-pk76snuy	42	20	an	an	DT
cord-016938-pk76snuy	42	21	artificial	artificial	JJ
cord-016938-pk76snuy	42	22	vector	vector	NN
cord-016938-pk76snuy	42	23	that	that	WDT
cord-016938-pk76snuy	42	24	provides	provide	VBZ
cord-016938-pk76snuy	42	25	efficient	efficient	JJ
cord-016938-pk76snuy	42	26	endosomal	endosomal	NN
cord-016938-pk76snuy	42	27	escape	escape	VB
cord-016938-pk76snuy	42	28	to	to	TO
cord-016938-pk76snuy	42	29	deliver	deliver	VB
cord-016938-pk76snuy	42	30	the	the	DT
cord-016938-pk76snuy	42	31	gene	gene	NN
cord-016938-pk76snuy	42	32	finally	finally	RB
cord-016938-pk76snuy	42	33	into	into	IN
cord-016938-pk76snuy	42	34	nucleus	nucleus	NN
cord-016938-pk76snuy	42	35	is	be	VBZ
cord-016938-pk76snuy	42	36	still	still	RB
cord-016938-pk76snuy	42	37	questionable	questionable	JJ
cord-016938-pk76snuy	42	38	at	at	IN
cord-016938-pk76snuy	42	39	present	present	NN
cord-016938-pk76snuy	42	40	.	.	.
cord-016938-pk76snuy	43	1	Biocompatibility	Biocompatibility	NNP
cord-016938-pk76snuy	43	2	is	be	VBZ
cord-016938-pk76snuy	43	3	the	the	DT
cord-016938-pk76snuy	43	4	primary	primary	JJ
cord-016938-pk76snuy	43	5	requirement	requirement	NN
cord-016938-pk76snuy	43	6	for	for	IN
cord-016938-pk76snuy	43	7	any	any	DT
cord-016938-pk76snuy	43	8	material	material	NN
cord-016938-pk76snuy	43	9	used	use	VBN
cord-016938-pk76snuy	43	10	in	in	IN
cord-016938-pk76snuy	43	11	manufacturing	manufacture	VBG
cord-016938-pk76snuy	43	12	implant	implant	NN
cord-016938-pk76snuy	43	13	.	.	.
cord-016938-pk76snuy	44	1	In	in	IN
cord-016938-pk76snuy	44	2	the	the	DT
cord-016938-pk76snuy	44	3	cell	cell	NN
cord-016938-pk76snuy	44	4	-	-	HYPH
cord-016938-pk76snuy	44	5	based	base	VBN
cord-016938-pk76snuy	44	6	implants	implant	NNS
cord-016938-pk76snuy	44	7	,	,	,
cord-016938-pk76snuy	44	8	the	the	DT
cord-016938-pk76snuy	44	9	material	material	NN
cord-016938-pk76snuy	44	10	hybridized	hybridize	VBN
cord-016938-pk76snuy	44	11	with	with	IN
cord-016938-pk76snuy	44	12	cells	cell	NNS
cord-016938-pk76snuy	44	13	shall	shall	MD
cord-016938-pk76snuy	44	14	either	either	CC
cord-016938-pk76snuy	44	15	biologically	biologically	RB
cord-016938-pk76snuy	44	16	or	or	CC
cord-016938-pk76snuy	44	17	mechanically	mechanically	RB
cord-016938-pk76snuy	44	18	be	be	VB
cord-016938-pk76snuy	44	19	compatible	compatible	JJ
cord-016938-pk76snuy	44	20	with	with	IN
cord-016938-pk76snuy	44	21	the	the	DT
cord-016938-pk76snuy	44	22	neighboring	neighboring	NN
cord-016938-pk76snuy	44	23	cells	cell	NNS
cord-016938-pk76snuy	44	24	at	at	IN
cord-016938-pk76snuy	44	25	the	the	DT
cord-016938-pk76snuy	44	26	delivered	deliver	VBN
cord-016938-pk76snuy	44	27	site	site	NN
cord-016938-pk76snuy	44	28	.	.	.
cord-016938-pk76snuy	45	1	For	for	IN
cord-016938-pk76snuy	45	2	cell	cell	NN
cord-016938-pk76snuy	45	3	therapy	therapy	NN
cord-016938-pk76snuy	45	4	,	,	,
cord-016938-pk76snuy	45	5	each	each	DT
cord-016938-pk76snuy	45	6	cell	cell	NN
cord-016938-pk76snuy	45	7	would	would	MD
cord-016938-pk76snuy	45	8	be	be	VB
cord-016938-pk76snuy	45	9	hybridized	hybridize	VBN
cord-016938-pk76snuy	45	10	with	with	IN
cord-016938-pk76snuy	45	11	nano	nano	NN
cord-016938-pk76snuy	45	12	-	-	HYPH
cord-016938-pk76snuy	45	13	sized	sized	JJ
cord-016938-pk76snuy	45	14	particles	particle	NNS
cord-016938-pk76snuy	45	15	that	that	WDT
cord-016938-pk76snuy	45	16	have	have	VBP
cord-016938-pk76snuy	45	17	specific	specific	JJ
cord-016938-pk76snuy	45	18	affinity	affinity	NN
cord-016938-pk76snuy	45	19	to	to	IN
cord-016938-pk76snuy	45	20	the	the	DT
cord-016938-pk76snuy	45	21	treatment	treatment	NN
cord-016938-pk76snuy	45	22	target	target	NN
cord-016938-pk76snuy	45	23	site	site	NN
cord-016938-pk76snuy	45	24	and	and	CC
cord-016938-pk76snuy	45	25	self	self	NN
cord-016938-pk76snuy	45	26	-	-	HYPH
cord-016938-pk76snuy	45	27	driving	drive	VBG
cord-016938-pk76snuy	45	28	ability	ability	NN
cord-016938-pk76snuy	45	29	.	.	.
cord-016938-pk76snuy	46	1	Particles	particle	NNS
cord-016938-pk76snuy	46	2	shall	shall	MD
cord-016938-pk76snuy	46	3	be	be	VB
cord-016938-pk76snuy	46	4	dissociated	dissociate	VBN
cord-016938-pk76snuy	46	5	from	from	IN
cord-016938-pk76snuy	46	6	the	the	DT
cord-016938-pk76snuy	46	7	delivered	deliver	VBN
cord-016938-pk76snuy	46	8	cell	cell	NN
cord-016938-pk76snuy	46	9	after	after	IN
cord-016938-pk76snuy	46	10	landing	land	VBG
cord-016938-pk76snuy	46	11	at	at	IN
cord-016938-pk76snuy	46	12	the	the	DT
cord-016938-pk76snuy	46	13	site	site	NN
cord-016938-pk76snuy	46	14	and	and	CC
cord-016938-pk76snuy	46	15	be	be	VB
cord-016938-pk76snuy	46	16	completely	completely	RB
cord-016938-pk76snuy	46	17	excreted	excrete	VBN
cord-016938-pk76snuy	46	18	without	without	IN
cord-016938-pk76snuy	46	19	accumulation	accumulation	NN
cord-016938-pk76snuy	46	20	in	in	IN
cord-016938-pk76snuy	46	21	the	the	DT
cord-016938-pk76snuy	46	22	recipient	recipient	NN
cord-016938-pk76snuy	46	23	's	's	POS
cord-016938-pk76snuy	46	24	body	body	NN
cord-016938-pk76snuy	46	25	and	and	CC
cord-016938-pk76snuy	46	26	any	any	DT
cord-016938-pk76snuy	46	27	side	side	NN
cord-016938-pk76snuy	46	28	effect	effect	NN
cord-016938-pk76snuy	46	29	.	.	.
cord-016938-pk76snuy	47	1	Size	size	NN
cord-016938-pk76snuy	47	2	of	of	IN
cord-016938-pk76snuy	47	3	a	a	DT
cord-016938-pk76snuy	47	4	tissue	tissue	NN
cord-016938-pk76snuy	47	5	cell	cell	NN
cord-016938-pk76snuy	47	6	is	be	VBZ
cord-016938-pk76snuy	47	7	about	about	RB
cord-016938-pk76snuy	47	8	10	10	CD
cord-016938-pk76snuy	47	9	×10	×10	NNS
cord-016938-pk76snuy	47	10	−5	−5	NNP
cord-016938-pk76snuy	47	11	m	m	NNP
cord-016938-pk76snuy	47	12	(=	(=	NNP
cord-016938-pk76snuy	47	13	10	10	CD
cord-016938-pk76snuy	47	14	μm	μm	NNS
cord-016938-pk76snuy	47	15	)	)	-RRB-
cord-016938-pk76snuy	47	16	,	,	,
cord-016938-pk76snuy	47	17	a	a	DT
cord-016938-pk76snuy	47	18	virus	virus	NN
cord-016938-pk76snuy	47	19	is	be	VBZ
cord-016938-pk76snuy	47	20	10	10	CD
cord-016938-pk76snuy	47	21	×10	×10	NFP
cord-016938-pk76snuy	47	22	−7	−7	XX
cord-016938-pk76snuy	48	1	m	m	NNP
cord-016938-pk76snuy	48	2	(=	(=	NNP
cord-016938-pk76snuy	48	3	100	100	CD
cord-016938-pk76snuy	48	4	nm	nm	NN
cord-016938-pk76snuy	48	5	)	)	-RRB-
cord-016938-pk76snuy	49	1	,	,	,
cord-016938-pk76snuy	49	2	diameter	diameter	NN
cord-016938-pk76snuy	49	3	of	of	IN
cord-016938-pk76snuy	49	4	a	a	DT
cord-016938-pk76snuy	49	5	DNA	dna	NN
cord-016938-pk76snuy	49	6	is	be	VBZ
cord-016938-pk76snuy	49	7	10	10	CD
cord-016938-pk76snuy	49	8	×10	×10	NNPS
cord-016938-pk76snuy	49	9	−8	−8	NNP
cord-016938-pk76snuy	49	10	m	m	NNP
cord-016938-pk76snuy	49	11	(=	(=	NNP
cord-016938-pk76snuy	49	12	10	10	CD
cord-016938-pk76snuy	49	13	nm	nm	NN
cord-016938-pk76snuy	49	14	)	)	-RRB-
cord-016938-pk76snuy	49	15	,	,	.
cord-016938-pk76snuy	50	1	diameter	diameter	NN
cord-016938-pk76snuy	50	2	of	of	IN
cord-016938-pk76snuy	50	3	a	a	DT
cord-016938-pk76snuy	50	4	hydrogen	hydrogen	NN
cord-016938-pk76snuy	50	5	atom	atom	NN
cord-016938-pk76snuy	50	6	is	be	VBZ
cord-016938-pk76snuy	50	7	10	10	CD
cord-016938-pk76snuy	50	8	×10	×10	NNS
cord-016938-pk76snuy	50	9	−9	−9	NNP
cord-016938-pk76snuy	50	10	m	m	NN
cord-016938-pk76snuy	50	11	(=	(=	NNP
cord-016938-pk76snuy	50	12	1	1	CD
cord-016938-pk76snuy	50	13	nm	nm	NNP
cord-016938-pk76snuy	50	14	)	)	-RRB-
cord-016938-pk76snuy	50	15	,	,	,
cord-016938-pk76snuy	50	16	and	and	CC
cord-016938-pk76snuy	50	17	hybridizing	hybridize	VBG
cord-016938-pk76snuy	50	18	substances	substance	NNS
cord-016938-pk76snuy	50	19	are	be	VBP
cord-016938-pk76snuy	50	20	smaller	small	JJR
cord-016938-pk76snuy	50	21	than	than	IN
cord-016938-pk76snuy	50	22	a	a	DT
cord-016938-pk76snuy	50	23	μm	μm	NN
cord-016938-pk76snuy	50	24	.	.	.
cord-016938-pk76snuy	51	1	However	however	RB
cord-016938-pk76snuy	51	2	,	,	,
cord-016938-pk76snuy	51	3	there	there	EX
cord-016938-pk76snuy	51	4	is	be	VBZ
cord-016938-pk76snuy	51	5	no	no	DT
cord-016938-pk76snuy	51	6	accurate	accurate	JJ
cord-016938-pk76snuy	51	7	tool	tool	NN
cord-016938-pk76snuy	51	8	to	to	TO
cord-016938-pk76snuy	51	9	detect	detect	VB
cord-016938-pk76snuy	51	10	these	these	DT
cord-016938-pk76snuy	51	11	extremely	extremely	RB
cord-016938-pk76snuy	51	12	small	small	JJ
cord-016938-pk76snuy	51	13	,	,	,
cord-016938-pk76snuy	51	14	nano	nano	NN
cord-016938-pk76snuy	51	15	-	-	HYPH
cord-016938-pk76snuy	51	16	scale	scale	NN
cord-016938-pk76snuy	51	17	particles	particle	NNS
cord-016938-pk76snuy	51	18	that	that	WDT
cord-016938-pk76snuy	51	19	exist	exist	VBP
cord-016938-pk76snuy	51	20	in	in	IN
cord-016938-pk76snuy	51	21	living	live	VBG
cord-016938-pk76snuy	51	22	body	body	NN
cord-016938-pk76snuy	51	23	for	for	IN
cord-016938-pk76snuy	51	24	safety	safety	NN
cord-016938-pk76snuy	51	25	evaluation	evaluation	NN
cord-016938-pk76snuy	51	26	of	of	IN
cord-016938-pk76snuy	51	27	a	a	DT
cord-016938-pk76snuy	51	28	substance	substance	NN
cord-016938-pk76snuy	51	29	at	at	IN
cord-016938-pk76snuy	51	30	present	present	NN
cord-016938-pk76snuy	51	31	.	.	.
cord-016938-pk76snuy	52	1	The	the	DT
cord-016938-pk76snuy	52	2	cell	cell	NN
cord-016938-pk76snuy	52	3	-	-	HYPH
cord-016938-pk76snuy	52	4	fabricating	fabricate	VBG
cord-016938-pk76snuy	52	5	operator	operator	NN
cord-016938-pk76snuy	52	6	might	may	MD
cord-016938-pk76snuy	52	7	be	be	VB
cord-016938-pk76snuy	52	8	exposed	expose	VBN
cord-016938-pk76snuy	52	9	to	to	IN
cord-016938-pk76snuy	52	10	the	the	DT
cord-016938-pk76snuy	52	11	substances	substance	NNS
cord-016938-pk76snuy	52	12	during	during	IN
cord-016938-pk76snuy	52	13	the	the	DT
cord-016938-pk76snuy	52	14	whole	whole	JJ
cord-016938-pk76snuy	52	15	manipulating	manipulate	VBG
cord-016938-pk76snuy	52	16	procedure	procedure	NN
cord-016938-pk76snuy	52	17	,	,	,
cord-016938-pk76snuy	52	18	and	and	CC
cord-016938-pk76snuy	52	19	further	further	JJ
cord-016938-pk76snuy	52	20	investigation	investigation	NN
cord-016938-pk76snuy	52	21	is	be	VBZ
cord-016938-pk76snuy	52	22	necessary	necessary	JJ
cord-016938-pk76snuy	52	23	to	to	TO
cord-016938-pk76snuy	52	24	avoid	avoid	VB
cord-016938-pk76snuy	52	25	hazards	hazard	NNS
cord-016938-pk76snuy	52	26	.	.	.
cord-016938-pk76snuy	53	1	Otherwise	otherwise	RB
cord-016938-pk76snuy	53	2	,	,	,
cord-016938-pk76snuy	53	3	currently	currently	RB
cord-016938-pk76snuy	53	4	introduced	introduce	VBN
cord-016938-pk76snuy	53	5	biomaterials	biomaterial	NNS
cord-016938-pk76snuy	53	6	for	for	IN
cord-016938-pk76snuy	53	7	cell	cell	NN
cord-016938-pk76snuy	53	8	encapsulation	encapsulation	NN
cord-016938-pk76snuy	53	9	are	be	VBP
cord-016938-pk76snuy	53	10	designed	design	VBN
cord-016938-pk76snuy	53	11	to	to	TO
cord-016938-pk76snuy	53	12	protect	protect	VB
cord-016938-pk76snuy	53	13	therapeutic	therapeutic	JJ
cord-016938-pk76snuy	53	14	cells	cell	NNS
cord-016938-pk76snuy	53	15	from	from	IN
cord-016938-pk76snuy	53	16	immune	immune	JJ
cord-016938-pk76snuy	53	17	rejection	rejection	NN
cord-016938-pk76snuy	53	18	while	while	IN
cord-016938-pk76snuy	53	19	providing	provide	VBG
cord-016938-pk76snuy	53	20	the	the	DT
cord-016938-pk76snuy	53	21	excretion	excretion	NN
cord-016938-pk76snuy	53	22	of	of	IN
cord-016938-pk76snuy	53	23	biologics	biologic	NNS
cord-016938-pk76snuy	53	24	from	from	IN
cord-016938-pk76snuy	53	25	the	the	DT
cord-016938-pk76snuy	53	26	cell	cell	NN
cord-016938-pk76snuy	53	27	,	,	,
cord-016938-pk76snuy	53	28	and	and	CC
cord-016938-pk76snuy	53	29	mostly	mostly	RB
cord-016938-pk76snuy	53	30	to	to	TO
cord-016938-pk76snuy	53	31	manufacture	manufacture	VB
cord-016938-pk76snuy	53	32	macromolecules	macromolecule	NNS
cord-016938-pk76snuy	53	33	with	with	IN
cord-016938-pk76snuy	53	34	less	less	JJR
cord-016938-pk76snuy	53	35	difficulty	difficulty	NN
cord-016938-pk76snuy	53	36	to	to	TO
cord-016938-pk76snuy	53	37	characterize	characterize	VB
cord-016938-pk76snuy	53	38	[	[	-LRB-
cord-016938-pk76snuy	53	39	3	3	CD
cord-016938-pk76snuy	53	40	]	]	-RRB-
cord-016938-pk76snuy	53	41	.	.	.
cord-016938-pk76snuy	54	1	In	in	IN
cord-016938-pk76snuy	54	2	producing	produce	VBG
cord-016938-pk76snuy	54	3	multicellular	multicellular	JJ
cord-016938-pk76snuy	54	4	structural	structural	JJ
cord-016938-pk76snuy	54	5	cell	cell	NN
cord-016938-pk76snuy	54	6	-	-	HYPH
cord-016938-pk76snuy	54	7	based	base	VBN
cord-016938-pk76snuy	54	8	implants	implant	NNS
cord-016938-pk76snuy	54	9	,	,	,
cord-016938-pk76snuy	54	10	so	so	CC
cord-016938-pk76snuy	54	11	called	call	VBN
cord-016938-pk76snuy	54	12	tissue	tissue	NN
cord-016938-pk76snuy	54	13	engineered	engineer	VBN
cord-016938-pk76snuy	54	14	implants	implant	NNS
cord-016938-pk76snuy	54	15	,	,	,
cord-016938-pk76snuy	54	16	various	various	JJ
cord-016938-pk76snuy	54	17	biomaterials	biomaterial	NNS
cord-016938-pk76snuy	54	18	of	of	IN
cord-016938-pk76snuy	54	19	either	either	DT
cord-016938-pk76snuy	54	20	synthetic	synthetic	JJ
cord-016938-pk76snuy	54	21	or	or	CC
cord-016938-pk76snuy	54	22	natural	natural	JJ
cord-016938-pk76snuy	54	23	substance	substance	NN
cord-016938-pk76snuy	54	24	are	be	VBP
cord-016938-pk76snuy	54	25	applied	apply	VBN
cord-016938-pk76snuy	54	26	.	.	.
cord-016938-pk76snuy	55	1	Basically	basically	RB
cord-016938-pk76snuy	55	2	,	,	,
cord-016938-pk76snuy	55	3	conventionally	conventionally	RB
cord-016938-pk76snuy	55	4	available	available	JJ
cord-016938-pk76snuy	55	5	biomaterials	biomaterial	NNS
cord-016938-pk76snuy	55	6	can	can	MD
cord-016938-pk76snuy	55	7	also	also	RB
cord-016938-pk76snuy	55	8	be	be	VB
cord-016938-pk76snuy	55	9	adopted	adopt	VBN
cord-016938-pk76snuy	55	10	as	as	RB
cord-016938-pk76snuy	55	11	long	long	RB
cord-016938-pk76snuy	55	12	as	as	IN
cord-016938-pk76snuy	55	13	the	the	DT
cord-016938-pk76snuy	55	14	permanent	permanent	JJ
cord-016938-pk76snuy	55	15	biocompatibility	biocompatibility	NN
cord-016938-pk76snuy	55	16	is	be	VBZ
cord-016938-pk76snuy	55	17	approved	approve	VBN
cord-016938-pk76snuy	55	18	.	.	.
cord-016938-pk76snuy	56	1	Synthetic	synthetic	JJ
cord-016938-pk76snuy	56	2	polymeric	polymeric	JJ
cord-016938-pk76snuy	56	3	biomaterials	biomaterial	NNS
cord-016938-pk76snuy	56	4	are	be	VBP
cord-016938-pk76snuy	56	5	the	the	DT
cord-016938-pk76snuy	56	6	representatives	representative	NNS
cord-016938-pk76snuy	56	7	,	,	,
cord-016938-pk76snuy	56	8	and	and	CC
cord-016938-pk76snuy	56	9	can	can	MD
cord-016938-pk76snuy	56	10	be	be	VB
cord-016938-pk76snuy	56	11	non	non	JJ
cord-016938-pk76snuy	56	12	-	-	JJ
cord-016938-pk76snuy	56	13	biodegradable	biodegradable	JJ
cord-016938-pk76snuy	56	14	or	or	CC
cord-016938-pk76snuy	56	15	biodegradable	biodegradable	JJ
cord-016938-pk76snuy	56	16	after	after	IN
cord-016938-pk76snuy	56	17	implantation	implantation	NN
cord-016938-pk76snuy	56	18	.	.	.
cord-016938-pk76snuy	57	1	Non	non	JJ
cord-016938-pk76snuy	57	2	-	-	JJ
cord-016938-pk76snuy	57	3	biodegradable	biodegradable	JJ
cord-016938-pk76snuy	57	4	materials	material	NNS
cord-016938-pk76snuy	57	5	are	be	VBP
cord-016938-pk76snuy	57	6	usually	usually	RB
cord-016938-pk76snuy	57	7	intended	intend	VBN
cord-016938-pk76snuy	57	8	for	for	IN
cord-016938-pk76snuy	57	9	use	use	NN
cord-016938-pk76snuy	57	10	in	in	IN
cord-016938-pk76snuy	57	11	cell	cell	NN
cord-016938-pk76snuy	57	12	therapy	therapy	NN
cord-016938-pk76snuy	57	13	where	where	WRB
cord-016938-pk76snuy	57	14	cell	cell	NN
cord-016938-pk76snuy	57	15	-	-	HYPH
cord-016938-pk76snuy	57	16	encapsulation	encapsulation	NN
cord-016938-pk76snuy	57	17	is	be	VBZ
cord-016938-pk76snuy	57	18	required	require	VBN
cord-016938-pk76snuy	57	19	to	to	TO
cord-016938-pk76snuy	57	20	provide	provide	VB
cord-016938-pk76snuy	57	21	and	and	CC
cord-016938-pk76snuy	57	22	maintain	maintain	VB
cord-016938-pk76snuy	57	23	optimal	optimal	JJ
cord-016938-pk76snuy	57	24	cellular	cellular	JJ
cord-016938-pk76snuy	57	25	function	function	NN
cord-016938-pk76snuy	58	1	(	(	-LRB-
cord-016938-pk76snuy	58	2	e.	e.	NNP
cord-016938-pk76snuy	58	3	g.	g.	NNP
cord-016938-pk76snuy	58	4	,	,	,
cord-016938-pk76snuy	58	5	alginate	alginate	NN
cord-016938-pk76snuy	58	6	,	,	,
cord-016938-pk76snuy	58	7	liposome	liposome	NN
cord-016938-pk76snuy	58	8	,	,	,
cord-016938-pk76snuy	58	9	etc	etc	FW
cord-016938-pk76snuy	58	10	.	.	.
cord-016938-pk76snuy	58	11	)	)	-RRB-
cord-016938-pk76snuy	59	1	by	by	IN
cord-016938-pk76snuy	59	2	protecting	protect	VBG
cord-016938-pk76snuy	59	3	the	the	DT
cord-016938-pk76snuy	59	4	cells	cell	NNS
cord-016938-pk76snuy	59	5	from	from	IN
cord-016938-pk76snuy	59	6	host	host	NN
cord-016938-pk76snuy	59	7	immune	immune	JJ
cord-016938-pk76snuy	59	8	reaction	reaction	NN
cord-016938-pk76snuy	59	9	,	,	,
cord-016938-pk76snuy	59	10	and/or	and/or	CC
cord-016938-pk76snuy	59	11	for	for	IN
cord-016938-pk76snuy	59	12	a	a	DT
cord-016938-pk76snuy	59	13	tissue	tissue	NN
cord-016938-pk76snuy	59	14	engineered	engineer	VBN
cord-016938-pk76snuy	59	15	implant	implant	RB
cord-016938-pk76snuy	59	16	,	,	,
cord-016938-pk76snuy	59	17	which	which	WDT
cord-016938-pk76snuy	59	18	requires	require	VBZ
cord-016938-pk76snuy	59	19	the	the	DT
cord-016938-pk76snuy	59	20	physiological	physiological	JJ
cord-016938-pk76snuy	59	21	load	load	NN
cord-016938-pk76snuy	59	22	-	-	HYPH
cord-016938-pk76snuy	59	23	bearing	bear	VBG
cord-016938-pk76snuy	59	24	compliance	compliance	NN
cord-016938-pk76snuy	59	25	(	(	-LRB-
cord-016938-pk76snuy	59	26	e.	e.	NNP
cord-016938-pk76snuy	59	27	g.	g.	NNP
cord-016938-pk76snuy	59	28	,	,	,
cord-016938-pk76snuy	59	29	polyurethane	polyurethane	NN
cord-016938-pk76snuy	59	30	scaffolds	scaffold	NNS
cord-016938-pk76snuy	59	31	for	for	IN
cord-016938-pk76snuy	59	32	blood	blood	NN
cord-016938-pk76snuy	59	33	vessels	vessel	NNS
cord-016938-pk76snuy	59	34	,	,	,
cord-016938-pk76snuy	59	35	tendons	tendon	NNS
cord-016938-pk76snuy	59	36	,	,	,
cord-016938-pk76snuy	59	37	ligaments	ligament	NNS
cord-016938-pk76snuy	59	38	,	,	,
cord-016938-pk76snuy	59	39	etc	etc	FW
cord-016938-pk76snuy	59	40	.	.	.
cord-016938-pk76snuy	59	41	)	)	-RRB-
cord-016938-pk76snuy	60	1	after	after	IN
cord-016938-pk76snuy	60	2	implantation	implantation	NN
cord-016938-pk76snuy	60	3	.	.	.
cord-016938-pk76snuy	61	1	They	-PRON-	PRP
cord-016938-pk76snuy	61	2	permanently	permanently	RB
cord-016938-pk76snuy	61	3	remain	remain	VBP
cord-016938-pk76snuy	61	4	at	at	IN
cord-016938-pk76snuy	61	5	the	the	DT
cord-016938-pk76snuy	61	6	planted	plant	VBN
cord-016938-pk76snuy	61	7	place	place	NN
cord-016938-pk76snuy	61	8	in	in	IN
cord-016938-pk76snuy	61	9	recipient	recipient	NN
cord-016938-pk76snuy	61	10	's	's	POS
cord-016938-pk76snuy	61	11	body	body	NN
cord-016938-pk76snuy	61	12	.	.	.
cord-016938-pk76snuy	62	1	Meanwhile	meanwhile	RB
cord-016938-pk76snuy	62	2	,	,	,
cord-016938-pk76snuy	62	3	biodegradable	biodegradable	JJ
cord-016938-pk76snuy	62	4	materials	material	NNS
cord-016938-pk76snuy	62	5	are	be	VBP
cord-016938-pk76snuy	62	6	usually	usually	RB
cord-016938-pk76snuy	62	7	intended	intend	VBN
cord-016938-pk76snuy	62	8	for	for	IN
cord-016938-pk76snuy	62	9	use	use	NN
cord-016938-pk76snuy	62	10	in	in	IN
cord-016938-pk76snuy	62	11	implants	implant	NNS
cord-016938-pk76snuy	62	12	which	which	WDT
cord-016938-pk76snuy	62	13	restore	restore	VBP
cord-016938-pk76snuy	62	14	the	the	DT
cord-016938-pk76snuy	62	15	histological	histological	JJ
cord-016938-pk76snuy	62	16	structure	structure	NN
cord-016938-pk76snuy	62	17	and	and	CC
cord-016938-pk76snuy	62	18	replace	replace	VB
cord-016938-pk76snuy	62	19	the	the	DT
cord-016938-pk76snuy	62	20	cellular	cellular	JJ
cord-016938-pk76snuy	62	21	function	function	NN
cord-016938-pk76snuy	62	22	of	of	IN
cord-016938-pk76snuy	62	23	recipients	recipient	NNS
cord-016938-pk76snuy	62	24	.	.	.
cord-016938-pk76snuy	63	1	They	-PRON-	PRP
cord-016938-pk76snuy	63	2	are	be	VBP
cord-016938-pk76snuy	63	3	gradually	gradually	RB
cord-016938-pk76snuy	63	4	degraded	degrade	VBN
cord-016938-pk76snuy	63	5	in	in	IN
cord-016938-pk76snuy	63	6	recipient	recipient	NN
cord-016938-pk76snuy	63	7	's	's	POS
cord-016938-pk76snuy	63	8	body	body	NN
cord-016938-pk76snuy	63	9	through	through	IN
cord-016938-pk76snuy	63	10	hydrolysis	hydrolysis	NN
cord-016938-pk76snuy	63	11	or	or	CC
cord-016938-pk76snuy	63	12	enzymatic	enzymatic	JJ
cord-016938-pk76snuy	63	13	function	function	NN
cord-016938-pk76snuy	63	14	after	after	IN
cord-016938-pk76snuy	63	15	implantation	implantation	NN
cord-016938-pk76snuy	63	16	(	(	-LRB-
cord-016938-pk76snuy	63	17	e.	e.	NNP
cord-016938-pk76snuy	63	18	g.	g.	NNP
cord-016938-pk76snuy	63	19	,	,	,
cord-016938-pk76snuy	63	20	poly	poly	NNP
cord-016938-pk76snuy	63	21	L	L	NNP
cord-016938-pk76snuy	63	22	-	-	HYPH
cord-016938-pk76snuy	63	23	lactic	lactic	NN
cord-016938-pk76snuy	63	24	acid	acid	NN
cord-016938-pk76snuy	63	25	,	,	,
cord-016938-pk76snuy	63	26	poly	poly	JJ
cord-016938-pk76snuy	63	27	glycolic	glycolic	NN
cord-016938-pk76snuy	63	28	acid	acid	NN
cord-016938-pk76snuy	63	29	,	,	,
cord-016938-pk76snuy	63	30	etc	etc	FW
cord-016938-pk76snuy	63	31	.	.	.
cord-016938-pk76snuy	63	32	)	)	-RRB-
cord-016938-pk76snuy	63	33	.	.	.
cord-016938-pk76snuy	64	1	In	in	IN
cord-016938-pk76snuy	64	2	cases	case	NNS
cord-016938-pk76snuy	64	3	of	of	IN
cord-016938-pk76snuy	64	4	using	use	VBG
cord-016938-pk76snuy	64	5	synthetic	synthetic	JJ
cord-016938-pk76snuy	64	6	polymeric	polymeric	JJ
cord-016938-pk76snuy	64	7	biomaterials	biomaterial	NNS
cord-016938-pk76snuy	64	8	,	,	,
cord-016938-pk76snuy	64	9	behavior	behavior	NN
cord-016938-pk76snuy	64	10	of	of	IN
cord-016938-pk76snuy	64	11	hybrid	hybrid	JJ
cord-016938-pk76snuy	64	12	cells	cell	NNS
cord-016938-pk76snuy	64	13	is	be	VBZ
cord-016938-pk76snuy	64	14	mainly	mainly	RB
cord-016938-pk76snuy	64	15	dependent	dependent	JJ
cord-016938-pk76snuy	64	16	on	on	IN
cord-016938-pk76snuy	64	17	surface	surface	NN
cord-016938-pk76snuy	64	18	characteristics	characteristic	NNS
cord-016938-pk76snuy	64	19	of	of	IN
cord-016938-pk76snuy	64	20	material	material	NN
cord-016938-pk76snuy	64	21	.	.	.
cord-016938-pk76snuy	65	1	Especially	especially	RB
cord-016938-pk76snuy	65	2	,	,	,
cord-016938-pk76snuy	65	3	the	the	DT
cord-016938-pk76snuy	65	4	cellular	cellular	JJ
cord-016938-pk76snuy	65	5	events	event	NNS
cord-016938-pk76snuy	65	6	such	such	JJ
cord-016938-pk76snuy	65	7	as	as	IN
cord-016938-pk76snuy	65	8	adhesion	adhesion	NN
cord-016938-pk76snuy	65	9	,	,	,
cord-016938-pk76snuy	65	10	differentiation	differentiation	NN
cord-016938-pk76snuy	65	11	,	,	,
cord-016938-pk76snuy	65	12	proliferation	proliferation	NN
cord-016938-pk76snuy	65	13	and	and	CC
cord-016938-pk76snuy	65	14	migration	migration	NN
cord-016938-pk76snuy	65	15	on	on	IN
cord-016938-pk76snuy	65	16	the	the	DT
cord-016938-pk76snuy	65	17	non	non	JJ
cord-016938-pk76snuy	65	18	-	-	JJ
cord-016938-pk76snuy	65	19	biological	biological	JJ
cord-016938-pk76snuy	65	20	synthetic	synthetic	JJ
cord-016938-pk76snuy	65	21	biomaterial	biomaterial	NN
cord-016938-pk76snuy	65	22	are	be	VBP
cord-016938-pk76snuy	65	23	important	important	JJ
cord-016938-pk76snuy	65	24	for	for	IN
cord-016938-pk76snuy	65	25	maintaining	maintain	VBG
cord-016938-pk76snuy	65	26	viability	viability	NN
cord-016938-pk76snuy	65	27	of	of	IN
cord-016938-pk76snuy	65	28	cells	cell	NNS
cord-016938-pk76snuy	65	29	implanted	implant	VBN
cord-016938-pk76snuy	65	30	in	in	IN
cord-016938-pk76snuy	65	31	bio	bio	JJ
cord-016938-pk76snuy	65	32	-	-	JJ
cord-016938-pk76snuy	65	33	inert	inert	JJ
cord-016938-pk76snuy	65	34	materials	material	NNS
cord-016938-pk76snuy	65	35	.	.	.
cord-016938-pk76snuy	66	1	Furthermore	furthermore	RB
cord-016938-pk76snuy	66	2	,	,	,
cord-016938-pk76snuy	66	3	an	an	DT
cord-016938-pk76snuy	66	4	increased	increase	VBN
cord-016938-pk76snuy	66	5	regional	regional	JJ
cord-016938-pk76snuy	66	6	acidity	acidity	NN
cord-016938-pk76snuy	66	7	induced	induce	VBN
cord-016938-pk76snuy	66	8	by	by	IN
cord-016938-pk76snuy	66	9	dissolved	dissolve	VBN
cord-016938-pk76snuy	66	10	acidic	acidic	JJ
cord-016938-pk76snuy	66	11	component	component	NN
cord-016938-pk76snuy	66	12	through	through	IN
cord-016938-pk76snuy	66	13	hydrolysis	hydrolysis	NN
cord-016938-pk76snuy	66	14	from	from	IN
cord-016938-pk76snuy	66	15	the	the	DT
cord-016938-pk76snuy	66	16	biodegradable	biodegradable	JJ
cord-016938-pk76snuy	66	17	materials	material	NNS
cord-016938-pk76snuy	66	18	demonstrates	demonstrate	VBZ
cord-016938-pk76snuy	66	19	the	the	DT
cord-016938-pk76snuy	66	20	limitation	limitation	NN
cord-016938-pk76snuy	66	21	in	in	IN
cord-016938-pk76snuy	66	22	mimicking	mimic	VBG
cord-016938-pk76snuy	66	23	natural	natural	JJ
cord-016938-pk76snuy	66	24	biological	biological	JJ
cord-016938-pk76snuy	66	25	environment	environment	NN
cord-016938-pk76snuy	66	26	with	with	IN
cord-016938-pk76snuy	66	27	synthetic	synthetic	JJ
cord-016938-pk76snuy	66	28	biomaterials	biomaterial	NNS
cord-016938-pk76snuy	66	29	.	.	.
cord-016938-pk76snuy	67	1	Natural	natural	JJ
cord-016938-pk76snuy	67	2	biomaterials	biomaterial	NNS
cord-016938-pk76snuy	67	3	are	be	VBP
cord-016938-pk76snuy	67	4	mainly	mainly	RB
cord-016938-pk76snuy	67	5	composed	compose	VBN
cord-016938-pk76snuy	67	6	of	of	IN
cord-016938-pk76snuy	67	7	extracellular	extracellular	JJ
cord-016938-pk76snuy	67	8	matrix	matrix	NN
cord-016938-pk76snuy	67	9	(	(	-LRB-
cord-016938-pk76snuy	67	10	ECM	ECM	NNP
cord-016938-pk76snuy	67	11	)	)	-RRB-
cord-016938-pk76snuy	67	12	components	component	NNS
cord-016938-pk76snuy	67	13	(	(	-LRB-
cord-016938-pk76snuy	67	14	including	include	VBG
cord-016938-pk76snuy	67	15	structural	structural	JJ
cord-016938-pk76snuy	67	16	components	component	NNS
cord-016938-pk76snuy	67	17	and	and	CC
cord-016938-pk76snuy	67	18	biomolecules	biomolecule	NNS
cord-016938-pk76snuy	67	19	)	)	-RRB-
cord-016938-pk76snuy	67	20	originated	originate	VBD
cord-016938-pk76snuy	67	21	from	from	IN
cord-016938-pk76snuy	67	22	autologous	autologous	JJ
cord-016938-pk76snuy	67	23	,	,	,
cord-016938-pk76snuy	67	24	allogeneic	allogeneic	NN
cord-016938-pk76snuy	67	25	and	and	CC
cord-016938-pk76snuy	67	26	xenogeneic	xenogeneic	NNS
cord-016938-pk76snuy	67	27	tissues	tissue	NNS
cord-016938-pk76snuy	67	28	of	of	IN
cord-016938-pk76snuy	67	29	mammalians	mammalian	NNS
cord-016938-pk76snuy	67	30	.	.	.
cord-016938-pk76snuy	68	1	Collagen	collagen	NN
cord-016938-pk76snuy	68	2	,	,	,
cord-016938-pk76snuy	68	3	elastin	elastin	NN
cord-016938-pk76snuy	68	4	,	,	,
cord-016938-pk76snuy	68	5	chondroitin-6-sulphate	chondroitin-6-sulphate	JJ
cord-016938-pk76snuy	68	6	and	and	CC
cord-016938-pk76snuy	68	7	hyaluronic	hyaluronic	NN
cord-016938-pk76snuy	68	8	acid	acid	NN
cord-016938-pk76snuy	68	9	are	be	VBP
cord-016938-pk76snuy	68	10	structural	structural	JJ
cord-016938-pk76snuy	68	11	components	component	NNS
cord-016938-pk76snuy	68	12	.	.	.
cord-016938-pk76snuy	69	1	Biomolecules	Biomolecules	NNP
cord-016938-pk76snuy	69	2	,	,	,
cord-016938-pk76snuy	69	3	such	such	JJ
cord-016938-pk76snuy	69	4	as	as	IN
cord-016938-pk76snuy	69	5	peptides	peptide	NNS
cord-016938-pk76snuy	69	6	,	,	,
cord-016938-pk76snuy	69	7	fibronectin	fibronectin	NN
cord-016938-pk76snuy	69	8	,	,	,
cord-016938-pk76snuy	69	9	laminin	laminin	NN
cord-016938-pk76snuy	69	10	,	,	,
cord-016938-pk76snuy	69	11	vitronectin	vitronectin	NN
cord-016938-pk76snuy	69	12	and	and	CC
cord-016938-pk76snuy	69	13	fibrin	fibrin	NN
cord-016938-pk76snuy	69	14	,	,	,
cord-016938-pk76snuy	69	15	and	and	CC
cord-016938-pk76snuy	69	16	cytokines	cytokine	NNS
cord-016938-pk76snuy	69	17	as	as	IN
cord-016938-pk76snuy	69	18	growth	growth	NN
cord-016938-pk76snuy	69	19	factors	factor	NNS
cord-016938-pk76snuy	69	20	and	and	CC
cord-016938-pk76snuy	69	21	apoptosis	apoptosis	NN
cord-016938-pk76snuy	69	22	signal	signal	NN
cord-016938-pk76snuy	69	23	promoters	promoter	NNS
cord-016938-pk76snuy	69	24	,	,	,
cord-016938-pk76snuy	69	25	are	be	VBP
cord-016938-pk76snuy	69	26	biologically	biologically	RB
cord-016938-pk76snuy	69	27	active	active	JJ
cord-016938-pk76snuy	69	28	substances	substance	NNS
cord-016938-pk76snuy	69	29	produced	produce	VBN
cord-016938-pk76snuy	69	30	by	by	IN
cord-016938-pk76snuy	69	31	nature	nature	NN
cord-016938-pk76snuy	69	32	.	.	.
cord-016938-pk76snuy	70	1	Non	non	JJ
cord-016938-pk76snuy	70	2	-	-	JJ
cord-016938-pk76snuy	70	3	mammalian	mammalian	JJ
cord-016938-pk76snuy	70	4	substances	substance	NNS
cord-016938-pk76snuy	70	5	such	such	JJ
cord-016938-pk76snuy	70	6	as	as	IN
cord-016938-pk76snuy	70	7	silk	silk	NN
cord-016938-pk76snuy	70	8	fibroin	fibroin	NNP
cord-016938-pk76snuy	70	9	,	,	,
cord-016938-pk76snuy	70	10	crab	crab	NN
cord-016938-pk76snuy	70	11	chitin	chitin	NN
cord-016938-pk76snuy	70	12	and	and	CC
cord-016938-pk76snuy	70	13	chitosan	chitosan	NN
cord-016938-pk76snuy	70	14	and	and	CC
cord-016938-pk76snuy	70	15	agar	agar	NN
cord-016938-pk76snuy	70	16	are	be	VBP
cord-016938-pk76snuy	70	17	also	also	RB
cord-016938-pk76snuy	70	18	included	include	VBN
cord-016938-pk76snuy	70	19	in	in	IN
cord-016938-pk76snuy	70	20	this	this	DT
cord-016938-pk76snuy	70	21	criteria	criterion	NNS
cord-016938-pk76snuy	70	22	.	.	.
cord-016938-pk76snuy	71	1	At	at	IN
cord-016938-pk76snuy	71	2	this	this	DT
cord-016938-pk76snuy	71	3	scope	scope	NN
cord-016938-pk76snuy	71	4	,	,	,
cord-016938-pk76snuy	71	5	it	-PRON-	PRP
cord-016938-pk76snuy	71	6	can	can	MD
cord-016938-pk76snuy	71	7	be	be	VB
cord-016938-pk76snuy	71	8	recognized	recognize	VBN
cord-016938-pk76snuy	71	9	that	that	IN
cord-016938-pk76snuy	71	10	,	,	,
cord-016938-pk76snuy	71	11	although	although	IN
cord-016938-pk76snuy	71	12	any	any	DT
cord-016938-pk76snuy	71	13	xenogeneic	xenogeneic	NNP
cord-016938-pk76snuy	71	14	cells	cell	NNS
cord-016938-pk76snuy	71	15	are	be	VBP
cord-016938-pk76snuy	71	16	still	still	RB
cord-016938-pk76snuy	71	17	not	not	RB
cord-016938-pk76snuy	71	18	permitted	permit	VBN
cord-016938-pk76snuy	71	19	,	,	,
cord-016938-pk76snuy	71	20	xenogeneic	xenogeneic	NNP
cord-016938-pk76snuy	71	21	ECM	ECM	NNP
cord-016938-pk76snuy	71	22	components	component	NNS
cord-016938-pk76snuy	71	23	are	be	VBP
cord-016938-pk76snuy	71	24	permitted	permit	VBN
cord-016938-pk76snuy	71	25	for	for	IN
cord-016938-pk76snuy	71	26	the	the	DT
cord-016938-pk76snuy	71	27	"	"	``
cord-016938-pk76snuy	71	28	trans-	trans-	JJ
cord-016938-pk76snuy	71	29	"	"	''
cord-016938-pk76snuy	71	30	or	or	CC
cord-016938-pk76snuy	71	31	"	"	``
cord-016938-pk76snuy	71	32	im-"plantable	im-"plantable	JJ
cord-016938-pk76snuy	71	33	biomaterials	biomaterial	NNS
cord-016938-pk76snuy	71	34	.	.	.
cord-016938-pk76snuy	72	1	For	for	IN
cord-016938-pk76snuy	72	2	cell	cell	NN
cord-016938-pk76snuy	72	3	-	-	HYPH
cord-016938-pk76snuy	72	4	based	base	VBN
cord-016938-pk76snuy	72	5	implants	implant	NNS
cord-016938-pk76snuy	72	6	that	that	WDT
cord-016938-pk76snuy	72	7	utilize	utilize	VBP
cord-016938-pk76snuy	72	8	xenogeneic	xenogeneic	NNS
cord-016938-pk76snuy	72	9	tissues	tissue	NNS
cord-016938-pk76snuy	72	10	or	or	CC
cord-016938-pk76snuy	72	11	their	-PRON-	PRP$
cord-016938-pk76snuy	72	12	derivatives	derivative	NNS
cord-016938-pk76snuy	72	13	as	as	IN
cord-016938-pk76snuy	72	14	biomaterials	biomaterial	NNS
cord-016938-pk76snuy	72	15	,	,	,
cord-016938-pk76snuy	72	16	secure	secure	JJ
cord-016938-pk76snuy	72	17	risk	risk	NN
cord-016938-pk76snuy	72	18	controls	control	NNS
cord-016938-pk76snuy	72	19	shall	shall	MD
cord-016938-pk76snuy	72	20	be	be	VB
cord-016938-pk76snuy	72	21	applied	apply	VBN
cord-016938-pk76snuy	72	22	on	on	IN
cord-016938-pk76snuy	72	23	sourcing	source	VBG
cord-016938-pk76snuy	72	24	,	,	,
cord-016938-pk76snuy	72	25	collecting	collect	VBG
cord-016938-pk76snuy	72	26	and	and	CC
cord-016938-pk76snuy	72	27	handling	handle	VBG
cord-016938-pk76snuy	72	28	xenogeneic	xenogeneic	NNS
cord-016938-pk76snuy	72	29	ECM	ECM	NNP
cord-016938-pk76snuy	72	30	,	,	,
cord-016938-pk76snuy	72	31	on	on	IN
cord-016938-pk76snuy	72	32	the	the	DT
cord-016938-pk76snuy	72	33	validation	validation	NN
cord-016938-pk76snuy	72	34	of	of	IN
cord-016938-pk76snuy	72	35	elimination	elimination	NN
cord-016938-pk76snuy	72	36	and/or	and/or	CC
cord-016938-pk76snuy	72	37	inactivation	inactivation	NN
cord-016938-pk76snuy	72	38	of	of	IN
cord-016938-pk76snuy	72	39	adventitious	adventitious	JJ
cord-016938-pk76snuy	72	40	agents	agent	NNS
cord-016938-pk76snuy	72	41	,	,	,
cord-016938-pk76snuy	72	42	such	such	JJ
cord-016938-pk76snuy	72	43	as	as	IN
cord-016938-pk76snuy	72	44	Transmissible	transmissible	JJ
cord-016938-pk76snuy	72	45	Spongiform	Spongiform	NNP
cord-016938-pk76snuy	72	46	Encephalopathy	Encephalopathy	NNP
cord-016938-pk76snuy	72	47	(	(	-LRB-
cord-016938-pk76snuy	72	48	TSE	TSE	NNP
cord-016938-pk76snuy	72	49	)	)	-RRB-
cord-016938-pk76snuy	72	50	agents	agent	NNS
cord-016938-pk76snuy	72	51	in	in	IN
cord-016938-pk76snuy	72	52	case	case	NN
cord-016938-pk76snuy	72	53	of	of	IN
cord-016938-pk76snuy	72	54	using	use	VBG
cord-016938-pk76snuy	72	55	bovine	bovine	JJ
cord-016938-pk76snuy	72	56	tissue	tissue	NN
cord-016938-pk76snuy	72	57	,	,	,
cord-016938-pk76snuy	72	58	in	in	IN
cord-016938-pk76snuy	72	59	products	product	NNS
cord-016938-pk76snuy	72	60	.	.	.
cord-016938-pk76snuy	73	1	Non	non	JJ
cord-016938-pk76snuy	73	2	-	-	JJ
cord-016938-pk76snuy	73	3	comparable	comparable	JJ
cord-016938-pk76snuy	73	4	biological	biological	JJ
cord-016938-pk76snuy	73	5	superiority	superiority	NN
cord-016938-pk76snuy	73	6	of	of	IN
cord-016938-pk76snuy	73	7	natural	natural	JJ
cord-016938-pk76snuy	73	8	ECM	ECM	NNP
cord-016938-pk76snuy	73	9	components	component	NNS
cord-016938-pk76snuy	73	10	are	be	VBP
cord-016938-pk76snuy	73	11	applied	apply	VBN
cord-016938-pk76snuy	73	12	for	for	IN
cord-016938-pk76snuy	73	13	improving	improve	VBG
cord-016938-pk76snuy	73	14	biocompatibility	biocompatibility	NN
cord-016938-pk76snuy	73	15	of	of	IN
cord-016938-pk76snuy	73	16	synthetic	synthetic	JJ
cord-016938-pk76snuy	73	17	polymeric	polymeric	JJ
cord-016938-pk76snuy	73	18	biomaterials	biomaterial	NNS
cord-016938-pk76snuy	73	19	as	as	IN
cord-016938-pk76snuy	73	20	grafting	graft	VBG
cord-016938-pk76snuy	73	21	materials	material	NNS
cord-016938-pk76snuy	73	22	onto	onto	IN
cord-016938-pk76snuy	73	23	the	the	DT
cord-016938-pk76snuy	73	24	surface	surface	NN
cord-016938-pk76snuy	73	25	of	of	IN
cord-016938-pk76snuy	73	26	material	material	NN
cord-016938-pk76snuy	73	27	.	.	.
cord-016938-pk76snuy	74	1	Also	also	RB
cord-016938-pk76snuy	74	2	,	,	,
cord-016938-pk76snuy	74	3	bioactive	bioactive	JJ
cord-016938-pk76snuy	74	4	agents	agent	NNS
cord-016938-pk76snuy	74	5	(	(	-LRB-
cord-016938-pk76snuy	74	6	including	include	VBG
cord-016938-pk76snuy	74	7	biologics	biologic	NNS
cord-016938-pk76snuy	74	8	,	,	,
cord-016938-pk76snuy	74	9	antibiotics	antibiotic	NNS
cord-016938-pk76snuy	74	10	,	,	,
cord-016938-pk76snuy	74	11	and	and	CC
cord-016938-pk76snuy	74	12	antimicrobials	antimicrobial	NNS
cord-016938-pk76snuy	74	13	)	)	-RRB-
cord-016938-pk76snuy	75	1	and/or	and/or	CC
cord-016938-pk76snuy	75	2	synthetic	synthetic	JJ
cord-016938-pk76snuy	75	3	drugs	drug	NNS
cord-016938-pk76snuy	75	4	can	can	MD
cord-016938-pk76snuy	75	5	be	be	VB
cord-016938-pk76snuy	75	6	medicinal	medicinal	JJ
cord-016938-pk76snuy	75	7	components	component	NNS
cord-016938-pk76snuy	75	8	in	in	IN
cord-016938-pk76snuy	75	9	biomaterials	biomaterial	NNS
cord-016938-pk76snuy	75	10	,	,	,
cord-016938-pk76snuy	75	11	and	and	CC
cord-016938-pk76snuy	75	12	they	-PRON-	PRP
cord-016938-pk76snuy	75	13	shall	shall	MD
cord-016938-pk76snuy	75	14	be	be	VB
cord-016938-pk76snuy	75	15	assessed	assess	VBN
cord-016938-pk76snuy	75	16	,	,	,
cord-016938-pk76snuy	75	17	in	in	IN
cord-016938-pk76snuy	75	18	the	the	DT
cord-016938-pk76snuy	75	19	context	context	NN
cord-016938-pk76snuy	75	20	of	of	IN
cord-016938-pk76snuy	75	21	their	-PRON-	PRP$
cord-016938-pk76snuy	75	22	integration	integration	NN
cord-016938-pk76snuy	75	23	with	with	IN
cord-016938-pk76snuy	75	24	the	the	DT
cord-016938-pk76snuy	75	25	cell	cell	NN
cord-016938-pk76snuy	75	26	-	-	HYPH
cord-016938-pk76snuy	75	27	based	base	VBN
cord-016938-pk76snuy	75	28	implant	implant	NN
cord-016938-pk76snuy	75	29	,	,	,
cord-016938-pk76snuy	75	30	according	accord	VBG
cord-016938-pk76snuy	75	31	to	to	IN
cord-016938-pk76snuy	75	32	pharmaceutical	pharmaceutical	JJ
cord-016938-pk76snuy	75	33	principles	principle	NNS
cord-016938-pk76snuy	75	34	.	.	.
cord-016938-pk76snuy	76	1	This	this	DT
cord-016938-pk76snuy	76	2	assessment	assessment	NN
cord-016938-pk76snuy	76	3	shall	shall	MD
cord-016938-pk76snuy	76	4	consider	consider	VB
cord-016938-pk76snuy	76	5	the	the	DT
cord-016938-pk76snuy	76	6	effects	effect	NNS
cord-016938-pk76snuy	76	7	of	of	IN
cord-016938-pk76snuy	76	8	medicinal	medicinal	JJ
cord-016938-pk76snuy	76	9	components	component	NNS
cord-016938-pk76snuy	76	10	on	on	IN
cord-016938-pk76snuy	76	11	product	product	NN
cord-016938-pk76snuy	76	12	and	and	CC
cord-016938-pk76snuy	76	13	vice	vice	NN
cord-016938-pk76snuy	76	14	versa	versa	RB
cord-016938-pk76snuy	76	15	.	.	.
cord-016938-pk76snuy	77	1	Furthermore	furthermore	RB
cord-016938-pk76snuy	77	2	,	,	,
cord-016938-pk76snuy	77	3	the	the	DT
cord-016938-pk76snuy	77	4	medicinal	medicinal	JJ
cord-016938-pk76snuy	77	5	components	component	NNS
cord-016938-pk76snuy	77	6	could	could	MD
cord-016938-pk76snuy	77	7	be	be	VB
cord-016938-pk76snuy	77	8	an	an	DT
cord-016938-pk76snuy	77	9	additive	additive	NN
cord-016938-pk76snuy	77	10	to	to	TO
cord-016938-pk76snuy	77	11	treat	treat	VB
cord-016938-pk76snuy	77	12	the	the	DT
cord-016938-pk76snuy	77	13	recipient	recipient	NN
cord-016938-pk76snuy	77	14	's	's	POS
cord-016938-pk76snuy	77	15	disease	disease	NN
cord-016938-pk76snuy	77	16	[	[	-LRB-
cord-016938-pk76snuy	77	17	4	4	CD
cord-016938-pk76snuy	77	18	]	]	-RRB-
cord-016938-pk76snuy	77	19	.	.	.
cord-016938-pk76snuy	78	1	In	in	IN
cord-016938-pk76snuy	78	2	mammalians	mammalian	NNS
cord-016938-pk76snuy	78	3	,	,	,
cord-016938-pk76snuy	78	4	collagen	collagen	NN
cord-016938-pk76snuy	78	5	comprises	comprise	VBZ
cord-016938-pk76snuy	78	6	about	about	IN
cord-016938-pk76snuy	78	7	30	30	CD
cord-016938-pk76snuy	78	8	%	%	NN
cord-016938-pk76snuy	78	9	of	of	IN
cord-016938-pk76snuy	78	10	total	total	JJ
cord-016938-pk76snuy	78	11	proteins	protein	NNS
cord-016938-pk76snuy	78	12	and	and	CC
cord-016938-pk76snuy	78	13	exists	exist	VBZ
cord-016938-pk76snuy	78	14	as	as	IN
cord-016938-pk76snuy	78	15	a	a	DT
cord-016938-pk76snuy	78	16	main	main	JJ
cord-016938-pk76snuy	78	17	structural	structural	JJ
cord-016938-pk76snuy	78	18	component	component	NN
cord-016938-pk76snuy	78	19	in	in	IN
cord-016938-pk76snuy	78	20	ECM	ECM	NNP
cord-016938-pk76snuy	78	21	and	and	CC
cord-016938-pk76snuy	78	22	supports	support	VBZ
cord-016938-pk76snuy	78	23	anatomical	anatomical	JJ
cord-016938-pk76snuy	78	24	morphology	morphology	NN
cord-016938-pk76snuy	78	25	of	of	IN
cord-016938-pk76snuy	78	26	every	every	DT
cord-016938-pk76snuy	78	27	tissue	tissue	NN
cord-016938-pk76snuy	78	28	and	and	CC
cord-016938-pk76snuy	78	29	organ	organ	NN
cord-016938-pk76snuy	78	30	.	.	.
cord-016938-pk76snuy	79	1	Although	although	IN
cord-016938-pk76snuy	79	2	more	more	JJR
cord-016938-pk76snuy	79	3	than	than	IN
cord-016938-pk76snuy	79	4	20	20	CD
cord-016938-pk76snuy	79	5	types	type	NNS
cord-016938-pk76snuy	79	6	of	of	IN
cord-016938-pk76snuy	79	7	them	-PRON-	PRP
cord-016938-pk76snuy	79	8	are	be	VBP
cord-016938-pk76snuy	79	9	informed	inform	VBN
cord-016938-pk76snuy	79	10	,	,	,
cord-016938-pk76snuy	79	11	type	type	NN
cord-016938-pk76snuy	79	12	I	-PRON-	PRP
cord-016938-pk76snuy	79	13	collagen	collagen	NN
cord-016938-pk76snuy	79	14	,	,	,
cord-016938-pk76snuy	79	15	which	which	WDT
cord-016938-pk76snuy	79	16	has	have	VBZ
cord-016938-pk76snuy	79	17	a	a	DT
cord-016938-pk76snuy	79	18	specific	specific	JJ
cord-016938-pk76snuy	79	19	molecule	molecule	NN
cord-016938-pk76snuy	79	20	of	of	IN
cord-016938-pk76snuy	79	21	the	the	DT
cord-016938-pk76snuy	79	22	super	super	RB
cord-016938-pk76snuy	79	23	-	-	JJ
cord-016938-pk76snuy	79	24	coiled	coiled	JJ
cord-016938-pk76snuy	79	25	triple	triple	JJ
cord-016938-pk76snuy	79	26	helical	helical	JJ
cord-016938-pk76snuy	79	27	peptide	peptide	NN
cord-016938-pk76snuy	79	28	chains	chain	NNS
cord-016938-pk76snuy	79	29	,	,	,
cord-016938-pk76snuy	79	30	is	be	VBZ
cord-016938-pk76snuy	79	31	the	the	DT
cord-016938-pk76snuy	79	32	most	most	RBS
cord-016938-pk76snuy	79	33	abundant	abundant	JJ
cord-016938-pk76snuy	79	34	in	in	IN
cord-016938-pk76snuy	79	35	body	body	NN
cord-016938-pk76snuy	79	36	.	.	.
cord-016938-pk76snuy	80	1	In	in	IN
cord-016938-pk76snuy	80	2	brief	brief	NN
cord-016938-pk76snuy	80	3	,	,	,
cord-016938-pk76snuy	80	4	each	each	DT
cord-016938-pk76snuy	80	5	peptide	peptide	NN
cord-016938-pk76snuy	80	6	chain	chain	NN
cord-016938-pk76snuy	80	7	is	be	VBZ
cord-016938-pk76snuy	80	8	a	a	DT
cord-016938-pk76snuy	80	9	specific	specific	JJ
cord-016938-pk76snuy	80	10	left	left	JJ
cord-016938-pk76snuy	80	11	-	-	HYPH
cord-016938-pk76snuy	80	12	handed	handed	JJ
cord-016938-pk76snuy	80	13	helix	helix	NN
cord-016938-pk76snuy	80	14	of	of	IN
cord-016938-pk76snuy	80	15	100,000	100,000	CD
cord-016938-pk76snuy	80	16	molecular	molecular	JJ
cord-016938-pk76snuy	80	17	weight	weight	NN
cord-016938-pk76snuy	80	18	and	and	CC
cord-016938-pk76snuy	80	19	consists	consist	VBZ
cord-016938-pk76snuy	80	20	of	of	IN
cord-016938-pk76snuy	80	21	repeating	repeat	VBG
cord-016938-pk76snuy	80	22	"	"	``
cord-016938-pk76snuy	80	23	-Glycine	-glycine	NN
cord-016938-pk76snuy	80	24	-	-	HYPH
cord-016938-pk76snuy	80	25	X	x	NN
cord-016938-pk76snuy	80	26	-	-	NN
cord-016938-pk76snuy	80	27	Y-	y-	DT
cord-016938-pk76snuy	80	28	"	"	''
cord-016938-pk76snuy	80	29	amino	amino	NN
cord-016938-pk76snuy	80	30	acid	acid	NN
cord-016938-pk76snuy	80	31	sequence	sequence	NN
cord-016938-pk76snuy	80	32	.	.	.
cord-016938-pk76snuy	81	1	As	as	IN
cord-016938-pk76snuy	81	2	the	the	DT
cord-016938-pk76snuy	81	3	arginine	arginine	NN
cord-016938-pk76snuy	81	4	-	-	HYPH
cord-016938-pk76snuy	81	5	glycine	glycine	NN
cord-016938-pk76snuy	81	6	-	-	HYPH
cord-016938-pk76snuy	81	7	aspartic	aspartic	JJ
cord-016938-pk76snuy	81	8	acid	acid	NN
cord-016938-pk76snuy	81	9	(	(	-LRB-
cord-016938-pk76snuy	81	10	RGD	RGD	NNP
cord-016938-pk76snuy	81	11	)	)	-RRB-
cord-016938-pk76snuy	81	12	sequence	sequence	NN
cord-016938-pk76snuy	81	13	is	be	VBZ
cord-016938-pk76snuy	81	14	a	a	DT
cord-016938-pk76snuy	81	15	typical	typical	JJ
cord-016938-pk76snuy	81	16	cell	cell	NN
cord-016938-pk76snuy	81	17	adhesive	adhesive	NN
cord-016938-pk76snuy	81	18	ligand	ligand	NN
cord-016938-pk76snuy	81	19	,	,	,
cord-016938-pk76snuy	81	20	collagen	collagen	NN
cord-016938-pk76snuy	81	21	demonstrates	demonstrate	VBZ
cord-016938-pk76snuy	81	22	strong	strong	JJ
cord-016938-pk76snuy	81	23	cell	cell	NN
cord-016938-pk76snuy	81	24	adhesion	adhesion	NN
cord-016938-pk76snuy	81	25	property	property	NN
cord-016938-pk76snuy	81	26	.	.	.
cord-016938-pk76snuy	82	1	3	3	CD
cord-016938-pk76snuy	82	2	left	left	JJ
cord-016938-pk76snuy	82	3	-	-	HYPH
cord-016938-pk76snuy	82	4	handed	handed	JJ
cord-016938-pk76snuy	82	5	helical	helical	JJ
cord-016938-pk76snuy	82	6	peptide	peptide	NN
cord-016938-pk76snuy	82	7	chains	chain	NNS
cord-016938-pk76snuy	82	8	are	be	VBP
cord-016938-pk76snuy	82	9	integrated	integrate	VBN
cord-016938-pk76snuy	82	10	by	by	IN
cord-016938-pk76snuy	82	11	intramolecular	intramolecular	JJ
cord-016938-pk76snuy	82	12	bindings	binding	NNS
cord-016938-pk76snuy	82	13	of	of	IN
cord-016938-pk76snuy	82	14	hydrogen	hydrogen	NN
cord-016938-pk76snuy	82	15	bonds	bond	NNS
cord-016938-pk76snuy	82	16	at	at	IN
cord-016938-pk76snuy	82	17	glycines	glycine	NNS
cord-016938-pk76snuy	82	18	to	to	IN
cord-016938-pk76snuy	82	19	glycines	glycine	NNS
cord-016938-pk76snuy	82	20	and	and	CC
cord-016938-pk76snuy	82	21	hydroxyl	hydroxyl	NN
cord-016938-pk76snuy	82	22	bonds	bond	NNS
cord-016938-pk76snuy	82	23	at	at	IN
cord-016938-pk76snuy	82	24	hydroxyprolines	hydroxyproline	NNS
cord-016938-pk76snuy	82	25	to	to	IN
cord-016938-pk76snuy	82	26	hydroxyprolines	hydroxyproline	NNS
cord-016938-pk76snuy	82	27	in	in	IN
cord-016938-pk76snuy	82	28	each	each	DT
cord-016938-pk76snuy	82	29	chain	chain	NN
cord-016938-pk76snuy	82	30	to	to	TO
cord-016938-pk76snuy	82	31	form	form	VB
cord-016938-pk76snuy	82	32	a	a	DT
cord-016938-pk76snuy	82	33	right	right	RB
cord-016938-pk76snuy	82	34	-	-	HYPH
cord-016938-pk76snuy	82	35	handed	handed	JJ
cord-016938-pk76snuy	82	36	triple	triple	JJ
cord-016938-pk76snuy	82	37	helical	helical	JJ
cord-016938-pk76snuy	82	38	collagen	collagen	NN
cord-016938-pk76snuy	82	39	molecule	molecule	NN
cord-016938-pk76snuy	82	40	.	.	.
cord-016938-pk76snuy	83	1	In	in	IN
cord-016938-pk76snuy	83	2	a	a	DT
cord-016938-pk76snuy	83	3	chain	chain	NN
cord-016938-pk76snuy	83	4	,	,	,
cord-016938-pk76snuy	83	5	1012	1012	CD
cord-016938-pk76snuy	83	6	amino	amino	NN
cord-016938-pk76snuy	83	7	acids	acid	NNS
cord-016938-pk76snuy	83	8	are	be	VBP
cord-016938-pk76snuy	83	9	involved	involve	VBN
cord-016938-pk76snuy	83	10	in	in	IN
cord-016938-pk76snuy	83	11	the	the	DT
cord-016938-pk76snuy	83	12	formation	formation	NN
cord-016938-pk76snuy	83	13	of	of	IN
cord-016938-pk76snuy	83	14	a	a	DT
cord-016938-pk76snuy	83	15	molecule	molecule	NN
cord-016938-pk76snuy	83	16	,	,	,
cord-016938-pk76snuy	83	17	and	and	CC
cord-016938-pk76snuy	83	18	each	each	DT
cord-016938-pk76snuy	83	19	free	free	JJ
cord-016938-pk76snuy	83	20	-	-	HYPH
cord-016938-pk76snuy	83	21	end	end	NN
cord-016938-pk76snuy	83	22	of	of	IN
cord-016938-pk76snuy	83	23	a	a	DT
cord-016938-pk76snuy	83	24	chain	chain	NN
cord-016938-pk76snuy	83	25	that	that	WDT
cord-016938-pk76snuy	83	26	is	be	VBZ
cord-016938-pk76snuy	83	27	not	not	RB
cord-016938-pk76snuy	83	28	integrated	integrate	VBN
cord-016938-pk76snuy	83	29	with	with	IN
cord-016938-pk76snuy	83	30	the	the	DT
cord-016938-pk76snuy	83	31	others	other	NNS
cord-016938-pk76snuy	83	32	,	,	,
cord-016938-pk76snuy	83	33	is	be	VBZ
cord-016938-pk76snuy	83	34	made	make	VBN
cord-016938-pk76snuy	83	35	of	of	IN
cord-016938-pk76snuy	83	36	12	12	CD
cord-016938-pk76snuy	83	37	-17	-17	CD
cord-016938-pk76snuy	83	38	amino	amino	JJ
cord-016938-pk76snuy	83	39	acids	acid	NNS
cord-016938-pk76snuy	83	40	and	and	CC
cord-016938-pk76snuy	83	41	named	name	VBN
cord-016938-pk76snuy	83	42	as	as	IN
cord-016938-pk76snuy	83	43	telopeptides	telopeptides	NNP
cord-016938-pk76snuy	83	44	.	.	.
cord-016938-pk76snuy	84	1	Each	each	DT
cord-016938-pk76snuy	84	2	of	of	IN
cord-016938-pk76snuy	84	3	these	these	DT
cord-016938-pk76snuy	84	4	at	at	IN
cord-016938-pk76snuy	84	5	the	the	DT
cord-016938-pk76snuy	84	6	C	C	NNP
cord-016938-pk76snuy	84	7	-	-	HYPH
cord-016938-pk76snuy	84	8	and	and	CC
cord-016938-pk76snuy	84	9	N	N	NNP
cord-016938-pk76snuy	84	10	-	-	HYPH
cord-016938-pk76snuy	84	11	terminals	terminal	NNS
cord-016938-pk76snuy	84	12	of	of	IN
cord-016938-pk76snuy	84	13	molecule	molecule	NN
cord-016938-pk76snuy	84	14	binds	bind	VBZ
cord-016938-pk76snuy	84	15	to	to	IN
cord-016938-pk76snuy	84	16	another	another	DT
cord-016938-pk76snuy	84	17	and	and	CC
cord-016938-pk76snuy	84	18	forms	form	VBZ
cord-016938-pk76snuy	84	19	a	a	DT
cord-016938-pk76snuy	84	20	long	long	JJ
cord-016938-pk76snuy	84	21	linear	linear	JJ
cord-016938-pk76snuy	84	22	chain	chain	NN
cord-016938-pk76snuy	84	23	.	.	.
cord-016938-pk76snuy	85	1	Collagen	collagen	NN
cord-016938-pk76snuy	85	2	is	be	VBZ
cord-016938-pk76snuy	85	3	easily	easily	RB
cord-016938-pk76snuy	85	4	denatured	denature	VBN
cord-016938-pk76snuy	85	5	at	at	IN
cord-016938-pk76snuy	85	6	temperature	temperature	NN
cord-016938-pk76snuy	85	7	over	over	IN
cord-016938-pk76snuy	85	8	37	37	CD
cord-016938-pk76snuy	85	9	•	•	NN
cord-016938-pk76snuy	85	10	C	c	NN
cord-016938-pk76snuy	85	11	through	through	IN
cord-016938-pk76snuy	85	12	disintegration	disintegration	NN
cord-016938-pk76snuy	85	13	of	of	IN
cord-016938-pk76snuy	85	14	the	the	DT
cord-016938-pk76snuy	85	15	intermolecular	intermolecular	JJ
cord-016938-pk76snuy	85	16	bonds	bond	NNS
cord-016938-pk76snuy	85	17	,	,	,
cord-016938-pk76snuy	85	18	and	and	CC
cord-016938-pk76snuy	85	19	becomes	become	VBZ
cord-016938-pk76snuy	85	20	gelatinized	gelatinize	VBN
cord-016938-pk76snuy	85	21	to	to	TO
cord-016938-pk76snuy	85	22	form	form	VB
cord-016938-pk76snuy	85	23	a	a	DT
cord-016938-pk76snuy	85	24	randomly	randomly	RB
cord-016938-pk76snuy	85	25	coiled	coil	VBN
cord-016938-pk76snuy	85	26	chain	chain	NN
cord-016938-pk76snuy	85	27	with	with	IN
cord-016938-pk76snuy	85	28	less	less	JJR
cord-016938-pk76snuy	85	29	viscosity	viscosity	NN
cord-016938-pk76snuy	85	30	than	than	IN
cord-016938-pk76snuy	85	31	that	that	DT
cord-016938-pk76snuy	85	32	of	of	IN
cord-016938-pk76snuy	85	33	collagen	collagen	NN
cord-016938-pk76snuy	85	34	.	.	.
cord-016938-pk76snuy	86	1	Once	once	RB
cord-016938-pk76snuy	86	2	denatured	denature	VBN
cord-016938-pk76snuy	86	3	,	,	,
cord-016938-pk76snuy	86	4	gelatin	gelatin	NN
cord-016938-pk76snuy	86	5	is	be	VBZ
cord-016938-pk76snuy	86	6	amorphous	amorphous	JJ
cord-016938-pk76snuy	86	7	and	and	CC
cord-016938-pk76snuy	86	8	does	do	VBZ
cord-016938-pk76snuy	86	9	recover	recover	VB
cord-016938-pk76snuy	86	10	the	the	DT
cord-016938-pk76snuy	86	11	intermolecular	intermolecular	JJ
cord-016938-pk76snuy	86	12	bonds	bond	NNS
cord-016938-pk76snuy	86	13	in	in	IN
cord-016938-pk76snuy	86	14	nature	nature	NN
cord-016938-pk76snuy	86	15	and	and	CC
cord-016938-pk76snuy	86	16	is	be	VBZ
cord-016938-pk76snuy	86	17	more	more	RBR
cord-016938-pk76snuy	86	18	easily	easily	RB
cord-016938-pk76snuy	86	19	digested	digest	VBN
cord-016938-pk76snuy	86	20	by	by	IN
cord-016938-pk76snuy	86	21	metaloprotease	metaloprotease	NNP
cord-016938-pk76snuy	86	22	than	than	IN
cord-016938-pk76snuy	86	23	collagen	collagen	NNP
cord-016938-pk76snuy	86	24	.	.	.
cord-016938-pk76snuy	87	1	A	a	DT
cord-016938-pk76snuy	87	2	type	type	NN
cord-016938-pk76snuy	87	3	I	-PRON-	PRP
cord-016938-pk76snuy	87	4	collagen	collagen	NN
cord-016938-pk76snuy	87	5	fibril	fibril	NN
cord-016938-pk76snuy	87	6	consists	consist	VBZ
cord-016938-pk76snuy	87	7	of	of	IN
cord-016938-pk76snuy	87	8	5	5	CD
cord-016938-pk76snuy	87	9	collagen	collagen	NN
cord-016938-pk76snuy	87	10	linear	linear	JJ
cord-016938-pk76snuy	87	11	chains	chain	NNS
cord-016938-pk76snuy	87	12	with	with	IN
cord-016938-pk76snuy	87	13	strong	strong	JJ
cord-016938-pk76snuy	87	14	intermolecular	intermolecular	JJ
cord-016938-pk76snuy	87	15	hydrogen	hydrogen	NN
cord-016938-pk76snuy	87	16	bonds	bond	NNS
cord-016938-pk76snuy	87	17	at	at	IN
cord-016938-pk76snuy	87	18	lysine	lysine	NN
cord-016938-pk76snuy	87	19	to	to	IN
cord-016938-pk76snuy	87	20	lysine	lysine	NN
cord-016938-pk76snuy	87	21	in	in	IN
cord-016938-pk76snuy	87	22	each	each	DT
cord-016938-pk76snuy	87	23	molecule	molecule	NN
cord-016938-pk76snuy	87	24	.	.	.
cord-016938-pk76snuy	88	1	In	in	IN
cord-016938-pk76snuy	88	2	nature	nature	NN
cord-016938-pk76snuy	88	3	,	,	,
cord-016938-pk76snuy	88	4	ε	ε	NNP
cord-016938-pk76snuy	88	5	-	-	HYPH
cord-016938-pk76snuy	88	6	NH	NH	NNP
cord-016938-pk76snuy	88	7	2	2	CD
cord-016938-pk76snuy	88	8	of	of	IN
cord-016938-pk76snuy	88	9	lysines	lysine	NNS
cord-016938-pk76snuy	88	10	and	and	CC
cord-016938-pk76snuy	88	11	hydroxylysines	hydroxylysines	NNP
cord-016938-pk76snuy	88	12	at	at	IN
cord-016938-pk76snuy	88	13	the	the	DT
cord-016938-pk76snuy	88	14	both	both	DT
cord-016938-pk76snuy	88	15	extremities	extremity	NNS
cord-016938-pk76snuy	88	16	of	of	IN
cord-016938-pk76snuy	88	17	telopeptide	telopeptide	NN
cord-016938-pk76snuy	88	18	is	be	VBZ
cord-016938-pk76snuy	88	19	converted	convert	VBN
cord-016938-pk76snuy	88	20	to	to	IN
cord-016938-pk76snuy	88	21	aldehydes	aldehyde	NNS
cord-016938-pk76snuy	88	22	by	by	IN
cord-016938-pk76snuy	88	23	lysineoxidase	lysineoxidase	NN
cord-016938-pk76snuy	88	24	,	,	,
cord-016938-pk76snuy	88	25	and	and	CC
cord-016938-pk76snuy	88	26	the	the	DT
cord-016938-pk76snuy	88	27	Schiff	Schiff	NNP
cord-016938-pk76snuy	88	28	base	base	NN
cord-016938-pk76snuy	88	29	formation	formation	NN
cord-016938-pk76snuy	88	30	by	by	IN
cord-016938-pk76snuy	88	31	binding	bind	VBG
cord-016938-pk76snuy	88	32	aldehyde	aldehyde	NN
cord-016938-pk76snuy	88	33	with	with	IN
cord-016938-pk76snuy	88	34	residual	residual	JJ
cord-016938-pk76snuy	88	35	ε	ε	NNP
cord-016938-pk76snuy	88	36	-	-	HYPH
cord-016938-pk76snuy	88	37	NH	NH	NNP
cord-016938-pk76snuy	88	38	2	2	CD
cord-016938-pk76snuy	88	39	or	or	CC
cord-016938-pk76snuy	88	40	by	by	IN
cord-016938-pk76snuy	88	41	aldol	aldol	NN
cord-016938-pk76snuy	88	42	condensation	condensation	NN
cord-016938-pk76snuy	88	43	between	between	IN
cord-016938-pk76snuy	88	44	aldehyde	aldehyde	NN
cord-016938-pk76snuy	88	45	to	to	IN
cord-016938-pk76snuy	88	46	aldehyde	aldehyde	NN
cord-016938-pk76snuy	88	47	occur	occur	VBP
cord-016938-pk76snuy	88	48	.	.	.
cord-016938-pk76snuy	89	1	This	this	DT
cord-016938-pk76snuy	89	2	strong	strong	JJ
cord-016938-pk76snuy	89	3	molecular	molecular	JJ
cord-016938-pk76snuy	89	4	binding	binding	NN
cord-016938-pk76snuy	89	5	is	be	VBZ
cord-016938-pk76snuy	89	6	called	call	VBN
cord-016938-pk76snuy	89	7	as	as	IN
cord-016938-pk76snuy	89	8	the	the	DT
cord-016938-pk76snuy	89	9	crosslinking	crosslinking	NN
cord-016938-pk76snuy	89	10	and	and	CC
cord-016938-pk76snuy	89	11	introduces	introduce	VBZ
cord-016938-pk76snuy	89	12	strong	strong	JJ
cord-016938-pk76snuy	89	13	mechanical	mechanical	JJ
cord-016938-pk76snuy	89	14	characteristics	characteristic	NNS
cord-016938-pk76snuy	89	15	to	to	IN
cord-016938-pk76snuy	89	16	collagen	collagen	NN
cord-016938-pk76snuy	89	17	to	to	TO
cord-016938-pk76snuy	89	18	act	act	VB
cord-016938-pk76snuy	89	19	as	as	IN
cord-016938-pk76snuy	89	20	the	the	DT
cord-016938-pk76snuy	89	21	structural	structural	JJ
cord-016938-pk76snuy	89	22	matrix	matrix	NN
cord-016938-pk76snuy	89	23	in	in	IN
cord-016938-pk76snuy	89	24	tissue	tissue	NN
cord-016938-pk76snuy	89	25	and	and	CC
cord-016938-pk76snuy	89	26	provide	provide	VB
cord-016938-pk76snuy	89	27	organ	organ	NN
cord-016938-pk76snuy	89	28	morphology	morphology	NN
cord-016938-pk76snuy	89	29	.	.	.
cord-016938-pk76snuy	90	1	As	as	IN
cord-016938-pk76snuy	90	2	hydrogen	hydrogen	NN
cord-016938-pk76snuy	90	3	concentration	concentration	NN
cord-016938-pk76snuy	90	4	of	of	IN
cord-016938-pk76snuy	90	5	body	body	NN
cord-016938-pk76snuy	90	6	fluid	fluid	NN
cord-016938-pk76snuy	90	7	is	be	VBZ
cord-016938-pk76snuy	90	8	pH	pH	NNP
cord-016938-pk76snuy	90	9	7.4	7.4	CD
cord-016938-pk76snuy	90	10	,	,	,
cord-016938-pk76snuy	90	11	collagen	collagen	NN
cord-016938-pk76snuy	90	12	is	be	VBZ
cord-016938-pk76snuy	90	13	regarded	regard	VBN
cord-016938-pk76snuy	90	14	as	as	IN
cord-016938-pk76snuy	90	15	a	a	DT
cord-016938-pk76snuy	90	16	weak	weak	JJ
cord-016938-pk76snuy	90	17	base	base	NN
cord-016938-pk76snuy	90	18	substance	substance	NN
cord-016938-pk76snuy	90	19	,	,	,
cord-016938-pk76snuy	90	20	and	and	CC
cord-016938-pk76snuy	90	21	is	be	VBZ
cord-016938-pk76snuy	90	22	generally	generally	RB
cord-016938-pk76snuy	90	23	extracted	extract	VBN
cord-016938-pk76snuy	90	24	from	from	IN
cord-016938-pk76snuy	90	25	mammalian	mammalian	JJ
cord-016938-pk76snuy	90	26	tissue	tissue	NN
cord-016938-pk76snuy	90	27	.	.	.
cord-016938-pk76snuy	91	1	Collagen	collagen	NN
cord-016938-pk76snuy	91	2	is	be	VBZ
cord-016938-pk76snuy	91	3	the	the	DT
cord-016938-pk76snuy	91	4	hydrophobic	hydrophobic	JJ
cord-016938-pk76snuy	91	5	protein	protein	NN
cord-016938-pk76snuy	91	6	and	and	CC
cord-016938-pk76snuy	91	7	is	be	VBZ
cord-016938-pk76snuy	91	8	generally	generally	RB
cord-016938-pk76snuy	91	9	insoluble	insoluble	JJ
cord-016938-pk76snuy	91	10	in	in	IN
cord-016938-pk76snuy	91	11	a	a	DT
cord-016938-pk76snuy	91	12	neutral	neutral	JJ
cord-016938-pk76snuy	91	13	solution	solution	NN
cord-016938-pk76snuy	91	14	,	,	,
cord-016938-pk76snuy	91	15	but	but	CC
cord-016938-pk76snuy	91	16	non	non	JJ
cord-016938-pk76snuy	91	17	-	-	JJ
cord-016938-pk76snuy	91	18	crosslinked	crosslinked	JJ
cord-016938-pk76snuy	91	19	collagen	collagen	NN
cord-016938-pk76snuy	91	20	is	be	VBZ
cord-016938-pk76snuy	91	21	soluble	soluble	JJ
cord-016938-pk76snuy	91	22	in	in	IN
cord-016938-pk76snuy	91	23	the	the	DT
cord-016938-pk76snuy	91	24	neutral	neutral	JJ
cord-016938-pk76snuy	91	25	base	base	NN
cord-016938-pk76snuy	91	26	solution	solution	NN
cord-016938-pk76snuy	91	27	such	such	JJ
cord-016938-pk76snuy	91	28	as	as	IN
cord-016938-pk76snuy	91	29	NaCl	NaCl	NNP
cord-016938-pk76snuy	91	30	or	or	CC
cord-016938-pk76snuy	91	31	Na	Na	NNP
cord-016938-pk76snuy	91	32	2	2	CD
cord-016938-pk76snuy	91	33	HPO	HPO	NNP
cord-016938-pk76snuy	91	34	4	4	CD
cord-016938-pk76snuy	91	35	.	.	.
cord-016938-pk76snuy	92	1	On	on	IN
cord-016938-pk76snuy	92	2	the	the	DT
cord-016938-pk76snuy	92	3	other	other	JJ
cord-016938-pk76snuy	92	4	hand	hand	NN
cord-016938-pk76snuy	92	5	,	,	,
cord-016938-pk76snuy	92	6	weak	weak	JJ
cord-016938-pk76snuy	92	7	acid	acid	NN
cord-016938-pk76snuy	92	8	such	such	JJ
cord-016938-pk76snuy	92	9	as	as	IN
cord-016938-pk76snuy	92	10	HCl	hcl	NN
cord-016938-pk76snuy	92	11	,	,	,
cord-016938-pk76snuy	92	12	citric	citric	JJ
cord-016938-pk76snuy	92	13	acid	acid	NN
cord-016938-pk76snuy	92	14	and	and	CC
cord-016938-pk76snuy	92	15	acetate	acetate	NN
cord-016938-pk76snuy	92	16	breaks	break	VBZ
cord-016938-pk76snuy	92	17	the	the	DT
cord-016938-pk76snuy	92	18	intermolecular	intermolecular	JJ
cord-016938-pk76snuy	92	19	Schiff	Schiff	NNP
cord-016938-pk76snuy	92	20	base	base	NN
cord-016938-pk76snuy	92	21	bonds	bond	NNS
cord-016938-pk76snuy	92	22	and	and	CC
cord-016938-pk76snuy	92	23	the	the	DT
cord-016938-pk76snuy	92	24	acid	acid	NN
cord-016938-pk76snuy	92	25	soluble	soluble	JJ
cord-016938-pk76snuy	92	26	collagen	collagen	NN
cord-016938-pk76snuy	92	27	molecules	molecule	NNS
cord-016938-pk76snuy	92	28	are	be	VBP
cord-016938-pk76snuy	92	29	extracted	extract	VBN
cord-016938-pk76snuy	92	30	.	.	.
cord-016938-pk76snuy	93	1	After	after	IN
cord-016938-pk76snuy	93	2	extracting	extract	VBG
cord-016938-pk76snuy	93	3	acid	acid	NN
cord-016938-pk76snuy	93	4	soluble	soluble	JJ
cord-016938-pk76snuy	93	5	collagen	collagen	NN
cord-016938-pk76snuy	93	6	,	,	,
cord-016938-pk76snuy	93	7	non	non	JJ
cord-016938-pk76snuy	93	8	-	-	JJ
cord-016938-pk76snuy	93	9	acid	acid	JJ
cord-016938-pk76snuy	93	10	soluble	soluble	JJ
cord-016938-pk76snuy	93	11	remnants	remnant	NNS
cord-016938-pk76snuy	93	12	remain	remain	VBP
cord-016938-pk76snuy	93	13	,	,	,
cord-016938-pk76snuy	93	14	and	and	CC
cord-016938-pk76snuy	93	15	these	these	DT
cord-016938-pk76snuy	93	16	are	be	VBP
cord-016938-pk76snuy	93	17	strongly	strongly	RB
cord-016938-pk76snuy	93	18	crosslinked	crosslinked	JJ
cord-016938-pk76snuy	93	19	collagen	collagen	NN
cord-016938-pk76snuy	93	20	fibrils	fibril	NNS
cord-016938-pk76snuy	93	21	.	.	.
cord-016938-pk76snuy	94	1	When	when	WRB
cord-016938-pk76snuy	94	2	additional	additional	JJ
cord-016938-pk76snuy	94	3	process	process	NN
cord-016938-pk76snuy	94	4	using	use	VBG
cord-016938-pk76snuy	94	5	pepsin	pepsin	NN
cord-016938-pk76snuy	94	6	that	that	WDT
cord-016938-pk76snuy	94	7	digests	digest	VBZ
cord-016938-pk76snuy	94	8	the	the	DT
cord-016938-pk76snuy	94	9	linear	linear	JJ
cord-016938-pk76snuy	94	10	intermolecular	intermolecular	JJ
cord-016938-pk76snuy	94	11	bonds	bond	NNS
cord-016938-pk76snuy	94	12	at	at	IN
cord-016938-pk76snuy	94	13	each	each	DT
cord-016938-pk76snuy	94	14	telopeptide	telopeptide	NN
cord-016938-pk76snuy	94	15	is	be	VBZ
cord-016938-pk76snuy	94	16	performed	perform	VBN
cord-016938-pk76snuy	94	17	,	,	,
cord-016938-pk76snuy	94	18	telopeptide	telopeptide	RB
cord-016938-pk76snuy	94	19	-	-	HYPH
cord-016938-pk76snuy	94	20	free	free	JJ
cord-016938-pk76snuy	94	21	collagen	collagen	NN
cord-016938-pk76snuy	94	22	molecules	molecule	NNS
cord-016938-pk76snuy	94	23	,	,	,
cord-016938-pk76snuy	94	24	known	know	VBN
cord-016938-pk76snuy	94	25	as	as	IN
cord-016938-pk76snuy	94	26	the	the	DT
cord-016938-pk76snuy	94	27	atelocollagen	atelocollagen	NN
cord-016938-pk76snuy	94	28	,	,	,
cord-016938-pk76snuy	94	29	can	can	MD
cord-016938-pk76snuy	94	30	be	be	VB
cord-016938-pk76snuy	94	31	obtained	obtain	VBN
cord-016938-pk76snuy	94	32	from	from	IN
cord-016938-pk76snuy	94	33	remaining	remain	VBG
cord-016938-pk76snuy	94	34	collagen	collagen	NN
cord-016938-pk76snuy	94	35	fibrils	fibril	NNS
cord-016938-pk76snuy	94	36	.	.	.
cord-016938-pk76snuy	95	1	Because	because	IN
cord-016938-pk76snuy	95	2	telopeptide	telopeptide	NNP
cord-016938-pk76snuy	95	3	demonstrates	demonstrate	VBZ
cord-016938-pk76snuy	95	4	individual	individual	JJ
cord-016938-pk76snuy	95	5	gene	gene	NN
cord-016938-pk76snuy	95	6	-	-	HYPH
cord-016938-pk76snuy	95	7	characteristics	characteristic	NNS
cord-016938-pk76snuy	95	8	,	,	,
cord-016938-pk76snuy	95	9	these	these	DT
cord-016938-pk76snuy	95	10	atelocollagen	atelocollagen	NN
cord-016938-pk76snuy	95	11	molecules	molecule	NNS
cord-016938-pk76snuy	95	12	are	be	VBP
cord-016938-pk76snuy	95	13	recognized	recognize	VBN
cord-016938-pk76snuy	95	14	as	as	IN
cord-016938-pk76snuy	95	15	immune	immune	JJ
cord-016938-pk76snuy	95	16	-	-	HYPH
cord-016938-pk76snuy	95	17	free	free	JJ
cord-016938-pk76snuy	95	18	substance	substance	NN
cord-016938-pk76snuy	95	19	and	and	CC
cord-016938-pk76snuy	95	20	are	be	VBP
cord-016938-pk76snuy	95	21	applicable	applicable	JJ
cord-016938-pk76snuy	95	22	to	to	IN
cord-016938-pk76snuy	95	23	medical	medical	JJ
cord-016938-pk76snuy	95	24	and	and	CC
cord-016938-pk76snuy	95	25	pharmaceutical	pharmaceutical	JJ
cord-016938-pk76snuy	95	26	purposes	purpose	NNS
cord-016938-pk76snuy	95	27	.	.	.
cord-016938-pk76snuy	96	1	High	high	JJ
cord-016938-pk76snuy	96	2	concentration	concentration	NN
cord-016938-pk76snuy	96	3	of	of	IN
cord-016938-pk76snuy	96	4	bases	basis	NNS
cord-016938-pk76snuy	96	5	such	such	JJ
cord-016938-pk76snuy	96	6	as	as	IN
cord-016938-pk76snuy	96	7	NaCl	NaCl	NNP
cord-016938-pk76snuy	96	8	,	,	,
cord-016938-pk76snuy	97	1	Na	Na	NNP
cord-016938-pk76snuy	97	2	2	2	CD
cord-016938-pk76snuy	97	3	SO	so	RB
cord-016938-pk76snuy	97	4	4	4	CD
cord-016938-pk76snuy	97	5	,	,	,
cord-016938-pk76snuy	97	6	Na	Na	NNP
cord-016938-pk76snuy	97	7	2	2	CD
cord-016938-pk76snuy	97	8	HPO	HPO	NNP
cord-016938-pk76snuy	97	9	4	4	CD
cord-016938-pk76snuy	97	10	aggregate	aggregate	VBP
cord-016938-pk76snuy	97	11	the	the	DT
cord-016938-pk76snuy	97	12	acid	acid	NN
cord-016938-pk76snuy	97	13	-	-	HYPH
cord-016938-pk76snuy	97	14	soluble	soluble	JJ
cord-016938-pk76snuy	97	15	collagen	collagen	NN
cord-016938-pk76snuy	97	16	molecules	molecule	NNS
cord-016938-pk76snuy	97	17	in	in	IN
cord-016938-pk76snuy	97	18	solution	solution	NN
cord-016938-pk76snuy	97	19	,	,	,
cord-016938-pk76snuy	97	20	and	and	CC
cord-016938-pk76snuy	97	21	this	this	DT
cord-016938-pk76snuy	97	22	phenomenon	phenomenon	NN
cord-016938-pk76snuy	97	23	is	be	VBZ
cord-016938-pk76snuy	97	24	applied	apply	VBN
cord-016938-pk76snuy	97	25	to	to	TO
cord-016938-pk76snuy	97	26	produce	produce	VB
cord-016938-pk76snuy	97	27	collagen	collagen	NN
cord-016938-pk76snuy	97	28	membranes	membrane	NNS
cord-016938-pk76snuy	97	29	,	,	,
cord-016938-pk76snuy	97	30	threads	thread	NNS
cord-016938-pk76snuy	97	31	and	and	CC
cord-016938-pk76snuy	97	32	hollow	hollow	JJ
cord-016938-pk76snuy	97	33	fibers	fiber	NNS
cord-016938-pk76snuy	97	34	.	.	.
cord-016938-pk76snuy	98	1	However	however	RB
cord-016938-pk76snuy	98	2	,	,	,
cord-016938-pk76snuy	98	3	randomly	randomly	RB
cord-016938-pk76snuy	98	4	reconstructed	reconstruct	VBN
cord-016938-pk76snuy	98	5	intramolecular	intramolecular	JJ
cord-016938-pk76snuy	98	6	and/or	and/or	CC
cord-016938-pk76snuy	98	7	intermolecular	intermolecular	JJ
cord-016938-pk76snuy	98	8	bonds	bond	NNS
cord-016938-pk76snuy	98	9	do	do	VBP
cord-016938-pk76snuy	98	10	not	not	RB
cord-016938-pk76snuy	98	11	provide	provide	VB
cord-016938-pk76snuy	98	12	sufficient	sufficient	JJ
cord-016938-pk76snuy	98	13	mechanical	mechanical	JJ
cord-016938-pk76snuy	98	14	properties	property	NNS
cord-016938-pk76snuy	98	15	compared	compare	VBN
cord-016938-pk76snuy	98	16	to	to	IN
cord-016938-pk76snuy	98	17	natural	natural	JJ
cord-016938-pk76snuy	98	18	collagen	collagen	NN
cord-016938-pk76snuy	98	19	in	in	IN
cord-016938-pk76snuy	98	20	tissue	tissue	NN
cord-016938-pk76snuy	98	21	.	.	.
cord-016938-pk76snuy	99	1	Hence	hence	RB
cord-016938-pk76snuy	99	2	,	,	,
cord-016938-pk76snuy	99	3	in	in	IN
cord-016938-pk76snuy	99	4	order	order	NN
cord-016938-pk76snuy	99	5	to	to	TO
cord-016938-pk76snuy	99	6	fabricate	fabricate	VB
cord-016938-pk76snuy	99	7	collagen	collagen	NN
cord-016938-pk76snuy	99	8	with	with	IN
cord-016938-pk76snuy	99	9	higher	high	JJR
cord-016938-pk76snuy	99	10	mechanical	mechanical	JJ
cord-016938-pk76snuy	99	11	strength	strength	NN
cord-016938-pk76snuy	99	12	,	,	,
cord-016938-pk76snuy	99	13	re	re	NN
cord-016938-pk76snuy	99	14	-	-	NN
cord-016938-pk76snuy	99	15	crosslinking	crosslinking	JJ
cord-016938-pk76snuy	99	16	methods	method	NNS
cord-016938-pk76snuy	99	17	are	be	VBP
cord-016938-pk76snuy	99	18	introduced	introduce	VBN
cord-016938-pk76snuy	99	19	[	[	-LRB-
cord-016938-pk76snuy	99	20	5	5	CD
cord-016938-pk76snuy	99	21	]	]	-RRB-
cord-016938-pk76snuy	100	1	(	(	-LRB-
cord-016938-pk76snuy	100	2	Fig	Fig	NNP
cord-016938-pk76snuy	100	3	.	.	.
cord-016938-pk76snuy	100	4	8.2	8.2	CD
cord-016938-pk76snuy	100	5	)	)	-RRB-
cord-016938-pk76snuy	100	6	.	.	.
cord-016938-pk76snuy	101	1	Collagen	collagen	NN
cord-016938-pk76snuy	101	2	has	have	VBZ
cord-016938-pk76snuy	101	3	been	be	VBN
cord-016938-pk76snuy	101	4	regarded	regard	VBN
cord-016938-pk76snuy	101	5	as	as	IN
cord-016938-pk76snuy	101	6	the	the	DT
cord-016938-pk76snuy	101	7	first	first	JJ
cord-016938-pk76snuy	101	8	candidate	candidate	NN
cord-016938-pk76snuy	101	9	for	for	IN
cord-016938-pk76snuy	101	10	hybridization	hybridization	NN
cord-016938-pk76snuy	101	11	with	with	IN
cord-016938-pk76snuy	101	12	cells	cell	NNS
cord-016938-pk76snuy	101	13	as	as	IN
cord-016938-pk76snuy	101	14	it	-PRON-	PRP
cord-016938-pk76snuy	101	15	exists	exist	VBZ
cord-016938-pk76snuy	101	16	in	in	IN
cord-016938-pk76snuy	101	17	every	every	DT
cord-016938-pk76snuy	101	18	part	part	NN
cord-016938-pk76snuy	101	19	of	of	IN
cord-016938-pk76snuy	101	20	body	body	NN
cord-016938-pk76snuy	101	21	as	as	IN
cord-016938-pk76snuy	101	22	the	the	DT
cord-016938-pk76snuy	101	23	main	main	JJ
cord-016938-pk76snuy	101	24	extracellular	extracellular	JJ
cord-016938-pk76snuy	101	25	matrix	matrix	NN
cord-016938-pk76snuy	101	26	component	component	NN
cord-016938-pk76snuy	101	27	.	.	.
cord-016938-pk76snuy	102	1	Although	although	IN
cord-016938-pk76snuy	102	2	implantation	implantation	NN
cord-016938-pk76snuy	102	3	of	of	IN
cord-016938-pk76snuy	102	4	xenogeneic	xenogeneic	NNP
cord-016938-pk76snuy	102	5	cells	cell	NNS
cord-016938-pk76snuy	102	6	is	be	VBZ
cord-016938-pk76snuy	102	7	not	not	RB
cord-016938-pk76snuy	102	8	practically	practically	RB
cord-016938-pk76snuy	102	9	permitted	permit	VBN
cord-016938-pk76snuy	102	10	,	,	,
cord-016938-pk76snuy	102	11	immunefree	immunefree	NNP
cord-016938-pk76snuy	102	12	atelocollagen	atelocollagen	NNP
cord-016938-pk76snuy	102	13	is	be	VBZ
cord-016938-pk76snuy	102	14	generally	generally	RB
cord-016938-pk76snuy	102	15	extracted	extract	VBN
cord-016938-pk76snuy	102	16	from	from	IN
cord-016938-pk76snuy	102	17	mammalians	mammalian	NNS
cord-016938-pk76snuy	102	18	for	for	IN
cord-016938-pk76snuy	102	19	medical	medical	JJ
cord-016938-pk76snuy	102	20	use	use	NN
cord-016938-pk76snuy	102	21	.	.	.
cord-016938-pk76snuy	103	1	Bovine	bovine	NN
cord-016938-pk76snuy	103	2	is	be	VBZ
cord-016938-pk76snuy	103	3	the	the	DT
cord-016938-pk76snuy	103	4	most	most	RBS
cord-016938-pk76snuy	103	5	popular	popular	JJ
cord-016938-pk76snuy	103	6	resource	resource	NN
cord-016938-pk76snuy	103	7	provided	provide	VBN
cord-016938-pk76snuy	103	8	if	if	IN
cord-016938-pk76snuy	103	9	cows	cow	NNS
cord-016938-pk76snuy	103	10	are	be	VBP
cord-016938-pk76snuy	103	11	grown	grow	VBN
cord-016938-pk76snuy	103	12	at	at	IN
cord-016938-pk76snuy	103	13	the	the	DT
cord-016938-pk76snuy	103	14	officially	officially	RB
cord-016938-pk76snuy	103	15	recognized	recognize	VBN
cord-016938-pk76snuy	103	16	region	region	NN
cord-016938-pk76snuy	103	17	that	that	WDT
cord-016938-pk76snuy	103	18	is	be	VBZ
cord-016938-pk76snuy	103	19	free	free	JJ
cord-016938-pk76snuy	103	20	from	from	IN
cord-016938-pk76snuy	103	21	TSE	TSE	NNP
cord-016938-pk76snuy	103	22	.	.	.
cord-016938-pk76snuy	104	1	As	as	IN
cord-016938-pk76snuy	104	2	atelocollagen	atelocollagen	NNP
cord-016938-pk76snuy	104	3	has	have	VBZ
cord-016938-pk76snuy	104	4	no	no	DT
cord-016938-pk76snuy	104	5	telopeptides	telopeptides	NN
cord-016938-pk76snuy	104	6	that	that	WDT
cord-016938-pk76snuy	104	7	integrate	integrate	VBP
cord-016938-pk76snuy	104	8	with	with	IN
cord-016938-pk76snuy	104	9	other	other	JJ
cord-016938-pk76snuy	104	10	atelocollagen	atelocollagen	NN
cord-016938-pk76snuy	104	11	molecules	molecule	NNS
cord-016938-pk76snuy	104	12	,	,	,
cord-016938-pk76snuy	104	13	basic	basic	JJ
cord-016938-pk76snuy	104	14	technology	technology	NN
cord-016938-pk76snuy	104	15	to	to	TO
cord-016938-pk76snuy	104	16	produce	produce	VB
cord-016938-pk76snuy	104	17	intramolecular	intramolecular	JJ
cord-016938-pk76snuy	104	18	and	and	CC
cord-016938-pk76snuy	104	19	intermolecular	intermolecular	JJ
cord-016938-pk76snuy	104	20	bonds	bond	NNS
cord-016938-pk76snuy	104	21	for	for	IN
cord-016938-pk76snuy	104	22	construction	construction	NN
cord-016938-pk76snuy	104	23	of	of	IN
cord-016938-pk76snuy	104	24	the	the	DT
cord-016938-pk76snuy	104	25	extracellular	extracellular	JJ
cord-016938-pk76snuy	104	26	matrix	matrix	NN
cord-016938-pk76snuy	104	27	with	with	IN
cord-016938-pk76snuy	104	28	adequate	adequate	JJ
cord-016938-pk76snuy	104	29	mechanical	mechanical	JJ
cord-016938-pk76snuy	104	30	properties	property	NNS
cord-016938-pk76snuy	104	31	required	require	VBN
cord-016938-pk76snuy	104	32	by	by	IN
cord-016938-pk76snuy	104	33	tissue	tissue	NN
cord-016938-pk76snuy	104	34	where	where	WRB
cord-016938-pk76snuy	104	35	the	the	DT
cord-016938-pk76snuy	104	36	artificial	artificial	JJ
cord-016938-pk76snuy	104	37	cell	cell	NN
cord-016938-pk76snuy	104	38	-	-	HYPH
cord-016938-pk76snuy	104	39	based	base	VBN
cord-016938-pk76snuy	104	40	implant	implant	NN
cord-016938-pk76snuy	104	41	is	be	VBZ
cord-016938-pk76snuy	104	42	delivered	deliver	VBN
cord-016938-pk76snuy	104	43	is	be	VBZ
cord-016938-pk76snuy	104	44	the	the	DT
cord-016938-pk76snuy	104	45	recrosslinking	recrosslinking	NN
cord-016938-pk76snuy	104	46	method	method	NN
cord-016938-pk76snuy	104	47	using	use	VBG
cord-016938-pk76snuy	104	48	chemical	chemical	JJ
cord-016938-pk76snuy	104	49	reagents	reagent	NNS
cord-016938-pk76snuy	104	50	or	or	CC
cord-016938-pk76snuy	104	51	physical	physical	JJ
cord-016938-pk76snuy	104	52	dynamics	dynamic	NNS
cord-016938-pk76snuy	104	53	.	.	.
cord-016938-pk76snuy	105	1	Most	Most	JJS
cord-016938-pk76snuy	105	2	common	common	JJ
cord-016938-pk76snuy	105	3	chemical	chemical	NN
cord-016938-pk76snuy	105	4	reagent	reagent	NN
cord-016938-pk76snuy	105	5	adopted	adopt	VBN
cord-016938-pk76snuy	105	6	for	for	IN
cord-016938-pk76snuy	105	7	this	this	DT
cord-016938-pk76snuy	105	8	process	process	NN
cord-016938-pk76snuy	105	9	is	be	VBZ
cord-016938-pk76snuy	105	10	glutaraldehyde	glutaraldehyde	VBN
cord-016938-pk76snuy	105	11	that	that	WDT
cord-016938-pk76snuy	105	12	introduces	introduce	VBZ
cord-016938-pk76snuy	105	13	stable	stable	JJ
cord-016938-pk76snuy	105	14	covalent	covalent	JJ
cord-016938-pk76snuy	105	15	NH	NH	NNP
cord-016938-pk76snuy	105	16	2	2	CD
cord-016938-pk76snuy	105	17	to	to	IN
cord-016938-pk76snuy	105	18	NH	NH	NNP
cord-016938-pk76snuy	105	19	2	2	CD
cord-016938-pk76snuy	105	20	bindings	binding	NNS
cord-016938-pk76snuy	105	21	between	between	IN
cord-016938-pk76snuy	105	22	the	the	DT
cord-016938-pk76snuy	105	23	molecules	molecule	NNS
cord-016938-pk76snuy	105	24	.	.	.
cord-016938-pk76snuy	106	1	As	as	IN
cord-016938-pk76snuy	106	2	amine	amine	NN
cord-016938-pk76snuy	106	3	to	to	IN
cord-016938-pk76snuy	106	4	amine	amine	NN
cord-016938-pk76snuy	106	5	(	(	-LRB-
cord-016938-pk76snuy	106	6	NH	NH	NNP
cord-016938-pk76snuy	106	7	-	-	HYPH
cord-016938-pk76snuy	106	8	NH	NH	NNP
cord-016938-pk76snuy	106	9	)	)	-RRB-
cord-016938-pk76snuy	106	10	bonding	bonding	NN
cord-016938-pk76snuy	106	11	exists	exist	VBZ
cord-016938-pk76snuy	106	12	in	in	IN
cord-016938-pk76snuy	106	13	every	every	DT
cord-016938-pk76snuy	106	14	amino	amino	NN
cord-016938-pk76snuy	106	15	acid	acid	NN
cord-016938-pk76snuy	106	16	in	in	IN
cord-016938-pk76snuy	106	17	molecules	molecule	NNS
cord-016938-pk76snuy	106	18	,	,	,
cord-016938-pk76snuy	106	19	the	the	DT
cord-016938-pk76snuy	106	20	chemically	chemically	RB
cord-016938-pk76snuy	106	21	crosslinked	crosslinke	VBN
cord-016938-pk76snuy	106	22	collagen	collagen	NN
cord-016938-pk76snuy	106	23	demonstrates	demonstrate	VBZ
cord-016938-pk76snuy	106	24	high	high	JJ
cord-016938-pk76snuy	106	25	strength	strength	NN
cord-016938-pk76snuy	106	26	,	,	,
cord-016938-pk76snuy	106	27	but	but	CC
cord-016938-pk76snuy	106	28	irregular	irregular	JJ
cord-016938-pk76snuy	106	29	patterns	pattern	NNS
cord-016938-pk76snuy	106	30	of	of	IN
cord-016938-pk76snuy	106	31	the	the	DT
cord-016938-pk76snuy	106	32	crosslinked	crosslinked	JJ
cord-016938-pk76snuy	106	33	fibers	fiber	NNS
cord-016938-pk76snuy	106	34	and	and	CC
cord-016938-pk76snuy	106	35	protracted	protracted	JJ
cord-016938-pk76snuy	106	36	resorption	resorption	NN
cord-016938-pk76snuy	106	37	are	be	VBP
cord-016938-pk76snuy	106	38	general	general	JJ
cord-016938-pk76snuy	106	39	disadvantages	disadvantage	NNS
cord-016938-pk76snuy	106	40	.	.	.
cord-016938-pk76snuy	107	1	Furthermore	furthermore	RB
cord-016938-pk76snuy	107	2	,	,	,
cord-016938-pk76snuy	107	3	in	in	IN
cord-016938-pk76snuy	107	4	case	case	NN
cord-016938-pk76snuy	107	5	of	of	IN
cord-016938-pk76snuy	107	6	using	use	VBG
cord-016938-pk76snuy	107	7	glutaraldehyde	glutaraldehyde	NN
cord-016938-pk76snuy	107	8	,	,	,
cord-016938-pk76snuy	107	9	complications	complication	NNS
cord-016938-pk76snuy	107	10	due	due	JJ
cord-016938-pk76snuy	107	11	to	to	IN
cord-016938-pk76snuy	107	12	residual	residual	JJ
cord-016938-pk76snuy	107	13	aldehydes	aldehyde	NNS
cord-016938-pk76snuy	107	14	often	often	RB
cord-016938-pk76snuy	107	15	conduct	conduct	VBP
cord-016938-pk76snuy	107	16	calcification	calcification	NN
cord-016938-pk76snuy	107	17	that	that	WDT
cord-016938-pk76snuy	107	18	directly	directly	RB
cord-016938-pk76snuy	107	19	leads	lead	VBZ
cord-016938-pk76snuy	107	20	to	to	IN
cord-016938-pk76snuy	107	21	the	the	DT
cord-016938-pk76snuy	107	22	loss	loss	NN
cord-016938-pk76snuy	107	23	of	of	IN
cord-016938-pk76snuy	107	24	mechanical	mechanical	JJ
cord-016938-pk76snuy	107	25	strength	strength	NN
cord-016938-pk76snuy	107	26	.	.	.
cord-016938-pk76snuy	108	1	To	to	TO
cord-016938-pk76snuy	108	2	overcome	overcome	VB
cord-016938-pk76snuy	108	3	these	these	DT
cord-016938-pk76snuy	108	4	disadvantages	disadvantage	NNS
cord-016938-pk76snuy	108	5	,	,	,
cord-016938-pk76snuy	108	6	1-ethyl-3(3-dimethylaminopropyl	1-ethyl-3(3-dimethylaminopropyl	CD
cord-016938-pk76snuy	108	7	)	)	-RRB-
cord-016938-pk76snuy	108	8	carbodiimide	carbodiimide	NNP
cord-016938-pk76snuy	108	9	(	(	-LRB-
cord-016938-pk76snuy	108	10	EDC	EDC	NNP
cord-016938-pk76snuy	108	11	)	)	-RRB-
cord-016938-pk76snuy	108	12	,	,	,
cord-016938-pk76snuy	108	13	which	which	WDT
cord-016938-pk76snuy	108	14	introduces	introduce	VBZ
cord-016938-pk76snuy	108	15	NH	NH	NNP
cord-016938-pk76snuy	108	16	2	2	CD
cord-016938-pk76snuy	108	17	to	to	IN
cord-016938-pk76snuy	108	18	COOH	COOH	NNP
cord-016938-pk76snuy	108	19	covalent	covalent	JJ
cord-016938-pk76snuy	108	20	bonding	bonding	NN
cord-016938-pk76snuy	108	21	and	and	CC
cord-016938-pk76snuy	108	22	has	have	VBZ
cord-016938-pk76snuy	108	23	no	no	DT
cord-016938-pk76snuy	108	24	toxicity	toxicity	NN
cord-016938-pk76snuy	108	25	,	,	,
cord-016938-pk76snuy	108	26	has	have	VBZ
cord-016938-pk76snuy	108	27	been	be	VBN
cord-016938-pk76snuy	108	28	applied	apply	VBN
cord-016938-pk76snuy	108	29	to	to	IN
cord-016938-pk76snuy	108	30	the	the	DT
cord-016938-pk76snuy	108	31	procedure	procedure	NN
cord-016938-pk76snuy	108	32	.	.	.
cord-016938-pk76snuy	109	1	To	to	TO
cord-016938-pk76snuy	109	2	avoid	avoid	VB
cord-016938-pk76snuy	109	3	any	any	DT
cord-016938-pk76snuy	109	4	disadvantage	disadvantage	NN
cord-016938-pk76snuy	109	5	arising	arise	VBG
cord-016938-pk76snuy	109	6	from	from	IN
cord-016938-pk76snuy	109	7	the	the	DT
cord-016938-pk76snuy	109	8	use	use	NN
cord-016938-pk76snuy	109	9	chemical	chemical	NN
cord-016938-pk76snuy	109	10	reagents	reagent	NNS
cord-016938-pk76snuy	109	11	,	,	,
cord-016938-pk76snuy	109	12	cross	cross	NN
cord-016938-pk76snuy	109	13	-	-	NN
cord-016938-pk76snuy	109	14	linking	link	VBG
cord-016938-pk76snuy	109	15	by	by	IN
cord-016938-pk76snuy	109	16	physical	physical	JJ
cord-016938-pk76snuy	109	17	method	method	NN
cord-016938-pk76snuy	109	18	is	be	VBZ
cord-016938-pk76snuy	109	19	employed	employ	VBN
cord-016938-pk76snuy	109	20	.	.	.
cord-016938-pk76snuy	110	1	Irradiating	irradiate	VBG
cord-016938-pk76snuy	110	2	with	with	IN
cord-016938-pk76snuy	110	3	gamma	gamma	NN
cord-016938-pk76snuy	110	4	or	or	CC
cord-016938-pk76snuy	110	5	ultraviolet	ultraviolet	JJ
cord-016938-pk76snuy	110	6	rays	ray	NNS
cord-016938-pk76snuy	110	7	produces	produce	VBZ
cord-016938-pk76snuy	110	8	radicals	radical	NNS
cord-016938-pk76snuy	110	9	in	in	IN
cord-016938-pk76snuy	110	10	the	the	DT
cord-016938-pk76snuy	110	11	form	form	NN
cord-016938-pk76snuy	110	12	of	of	IN
cord-016938-pk76snuy	110	13	unpaired	unpaired	JJ
cord-016938-pk76snuy	110	14	electrons	electron	NNS
cord-016938-pk76snuy	110	15	in	in	IN
cord-016938-pk76snuy	110	16	the	the	DT
cord-016938-pk76snuy	110	17	nuclei	nucleus	NNS
cord-016938-pk76snuy	110	18	of	of	IN
cord-016938-pk76snuy	110	19	aromatic	aromatic	JJ
cord-016938-pk76snuy	110	20	residues	residue	NNS
cord-016938-pk76snuy	110	21	such	such	JJ
cord-016938-pk76snuy	110	22	as	as	IN
cord-016938-pk76snuy	110	23	those	those	DT
cord-016938-pk76snuy	110	24	in	in	IN
cord-016938-pk76snuy	110	25	tyrosine	tyrosine	NN
cord-016938-pk76snuy	110	26	and	and	CC
cord-016938-pk76snuy	110	27	phenylalanine	phenylalanine	NN
cord-016938-pk76snuy	110	28	,	,	,
cord-016938-pk76snuy	110	29	and	and	CC
cord-016938-pk76snuy	110	30	binding	binding	NN
cord-016938-pk76snuy	110	31	of	of	IN
cord-016938-pk76snuy	110	32	these	these	DT
cord-016938-pk76snuy	110	33	radicals	radical	NNS
cord-016938-pk76snuy	110	34	results	result	VBZ
cord-016938-pk76snuy	110	35	in	in	IN
cord-016938-pk76snuy	110	36	the	the	DT
cord-016938-pk76snuy	110	37	collagen	collagen	NN
cord-016938-pk76snuy	110	38	cross	cross	NN
cord-016938-pk76snuy	110	39	-	-	JJ
cord-016938-pk76snuy	110	40	linking	link	VBG
cord-016938-pk76snuy	110	41	through	through	IN
cord-016938-pk76snuy	110	42	random	random	JJ
cord-016938-pk76snuy	110	43	NH	NH	NNP
cord-016938-pk76snuy	110	44	2	2	CD
cord-016938-pk76snuy	110	45	to	to	IN
cord-016938-pk76snuy	110	46	COOH	COOH	NNP
cord-016938-pk76snuy	110	47	bonding	bonding	NN
cord-016938-pk76snuy	110	48	.	.	.
cord-016938-pk76snuy	111	1	Even	even	RB
cord-016938-pk76snuy	111	2	though	though	IN
cord-016938-pk76snuy	111	3	the	the	DT
cord-016938-pk76snuy	111	4	physical	physical	JJ
cord-016938-pk76snuy	111	5	method	method	NN
cord-016938-pk76snuy	111	6	is	be	VBZ
cord-016938-pk76snuy	111	7	safe	safe	JJ
cord-016938-pk76snuy	111	8	as	as	IN
cord-016938-pk76snuy	111	9	it	-PRON-	PRP
cord-016938-pk76snuy	111	10	does	do	VBZ
cord-016938-pk76snuy	111	11	not	not	RB
cord-016938-pk76snuy	111	12	involve	involve	VB
cord-016938-pk76snuy	111	13	the	the	DT
cord-016938-pk76snuy	111	14	use	use	NN
cord-016938-pk76snuy	111	15	of	of	IN
cord-016938-pk76snuy	111	16	chemicals	chemical	NNS
cord-016938-pk76snuy	111	17	,	,	,
cord-016938-pk76snuy	111	18	stability	stability	NN
cord-016938-pk76snuy	111	19	of	of	IN
cord-016938-pk76snuy	111	20	the	the	DT
cord-016938-pk76snuy	111	21	crosslink	crosslink	NN
cord-016938-pk76snuy	111	22	is	be	VBZ
cord-016938-pk76snuy	111	23	less	less	JJR
cord-016938-pk76snuy	111	24	than	than	IN
cord-016938-pk76snuy	111	25	that	that	DT
cord-016938-pk76snuy	111	26	of	of	IN
cord-016938-pk76snuy	111	27	chemically	chemically	RB
cord-016938-pk76snuy	111	28	induced	induce	VBN
cord-016938-pk76snuy	111	29	crosslink	crosslink	NN
cord-016938-pk76snuy	111	30	.	.	.
cord-016938-pk76snuy	112	1	Collagen	collagen	NN
cord-016938-pk76snuy	112	2	can	can	MD
cord-016938-pk76snuy	112	3	be	be	VB
cord-016938-pk76snuy	112	4	fabricated	fabricate	VBN
cord-016938-pk76snuy	112	5	into	into	IN
cord-016938-pk76snuy	112	6	various	various	JJ
cord-016938-pk76snuy	112	7	forms	form	NNS
cord-016938-pk76snuy	112	8	of	of	IN
cord-016938-pk76snuy	112	9	gel	gel	NN
cord-016938-pk76snuy	112	10	,	,	,
cord-016938-pk76snuy	112	11	fiber	fiber	NN
cord-016938-pk76snuy	112	12	,	,	,
cord-016938-pk76snuy	112	13	membrane	membrane	NN
cord-016938-pk76snuy	112	14	with	with	IN
cord-016938-pk76snuy	112	15	or	or	CC
cord-016938-pk76snuy	112	16	without	without	IN
cord-016938-pk76snuy	112	17	pores	pore	NNS
cord-016938-pk76snuy	112	18	,	,	,
cord-016938-pk76snuy	112	19	and	and	CC
cord-016938-pk76snuy	112	20	it	-PRON-	PRP
cord-016938-pk76snuy	112	21	can	can	MD
cord-016938-pk76snuy	112	22	even	even	RB
cord-016938-pk76snuy	112	23	be	be	VB
cord-016938-pk76snuy	112	24	grafted	graft	VBN
cord-016938-pk76snuy	112	25	onto	onto	IN
cord-016938-pk76snuy	112	26	the	the	DT
cord-016938-pk76snuy	112	27	non	non	JJ
cord-016938-pk76snuy	112	28	-	-	JJ
cord-016938-pk76snuy	112	29	viable	viable	JJ
cord-016938-pk76snuy	112	30	metal	metal	NN
cord-016938-pk76snuy	112	31	,	,	,
cord-016938-pk76snuy	112	32	ceramic	ceramic	JJ
cord-016938-pk76snuy	112	33	and	and	CC
cord-016938-pk76snuy	112	34	synthetic	synthetic	JJ
cord-016938-pk76snuy	112	35	biomaterials	biomaterial	NNS
cord-016938-pk76snuy	112	36	to	to	TO
cord-016938-pk76snuy	112	37	introduce	introduce	VB
cord-016938-pk76snuy	112	38	biological	biological	JJ
cord-016938-pk76snuy	112	39	layer	layer	NN
cord-016938-pk76snuy	112	40	on	on	IN
cord-016938-pk76snuy	112	41	surface	surface	NN
cord-016938-pk76snuy	112	42	.	.	.
cord-016938-pk76snuy	113	1	Atelocollagen	Atelocollagen	NNP
cord-016938-pk76snuy	113	2	gel	gel	NN
cord-016938-pk76snuy	113	3	is	be	VBZ
cord-016938-pk76snuy	113	4	easily	easily	RB
cord-016938-pk76snuy	113	5	prepared	prepare	VBN
cord-016938-pk76snuy	113	6	by	by	IN
cord-016938-pk76snuy	113	7	dispersing	disperse	VBG
cord-016938-pk76snuy	113	8	in	in	IN
cord-016938-pk76snuy	113	9	weak	weak	JJ
cord-016938-pk76snuy	113	10	acidic	acidic	JJ
cord-016938-pk76snuy	113	11	solutions	solution	NNS
cord-016938-pk76snuy	113	12	.	.	.
cord-016938-pk76snuy	114	1	In	in	IN
cord-016938-pk76snuy	114	2	general	general	JJ
cord-016938-pk76snuy	114	3	,	,	,
cord-016938-pk76snuy	114	4	collagen	collagen	NN
cord-016938-pk76snuy	114	5	is	be	VBZ
cord-016938-pk76snuy	114	6	dispersed	disperse	VBN
cord-016938-pk76snuy	114	7	in	in	IN
cord-016938-pk76snuy	114	8	a	a	DT
cord-016938-pk76snuy	114	9	weak	weak	JJ
cord-016938-pk76snuy	114	10	acid	acid	NN
cord-016938-pk76snuy	114	11	solution	solution	NN
cord-016938-pk76snuy	114	12	of	of	IN
cord-016938-pk76snuy	114	13	pH	pH	NNP
cord-016938-pk76snuy	114	14	6	6	CD
cord-016938-pk76snuy	114	15	-	-	SYM
cord-016938-pk76snuy	114	16	6.5	6.5	CD
cord-016938-pk76snuy	114	17	and	and	CC
cord-016938-pk76snuy	114	18	finally	finally	RB
cord-016938-pk76snuy	114	19	adjusted	adjust	VBN
cord-016938-pk76snuy	114	20	to	to	IN
cord-016938-pk76snuy	114	21	required	require	VBN
cord-016938-pk76snuy	114	22	pH	ph	NN
cord-016938-pk76snuy	114	23	by	by	IN
cord-016938-pk76snuy	114	24	adding	add	VBG
cord-016938-pk76snuy	114	25	base	base	NN
cord-016938-pk76snuy	114	26	for	for	IN
cord-016938-pk76snuy	114	27	medical	medical	JJ
cord-016938-pk76snuy	114	28	purpose	purpose	NN
cord-016938-pk76snuy	114	29	.	.	.
cord-016938-pk76snuy	115	1	Additive	additive	NN
cord-016938-pk76snuy	115	2	substance	substance	NN
cord-016938-pk76snuy	115	3	to	to	IN
cord-016938-pk76snuy	115	4	Ultimate	ultimate	JJ
cord-016938-pk76snuy	115	5	tensile	tensile	JJ
cord-016938-pk76snuy	115	6	stress	stress	NN
cord-016938-pk76snuy	115	7	of	of	IN
cord-016938-pk76snuy	115	8	dense	dense	JJ
cord-016938-pk76snuy	115	9	membrane	membrane	NN
cord-016938-pk76snuy	115	10	in	in	IN
cord-016938-pk76snuy	115	11	relation	relation	NN
cord-016938-pk76snuy	115	12	to	to	IN
cord-016938-pk76snuy	115	13	UV	uv	NN
cord-016938-pk76snuy	115	14	irradiation	irradiation	NN
cord-016938-pk76snuy	115	15	time	time	NN
cord-016938-pk76snuy	115	16	.	.	.
cord-016938-pk76snuy	116	1	Each	each	DT
cord-016938-pk76snuy	116	2	value	value	NN
cord-016938-pk76snuy	116	3	represents	represent	VBZ
cord-016938-pk76snuy	116	4	the	the	DT
cord-016938-pk76snuy	116	5	mean	mean	JJ
cord-016938-pk76snuy	116	6	±	±	NNP
cord-016938-pk76snuy	116	7	SD	SD	NNP
cord-016938-pk76snuy	116	8	in	in	IN
cord-016938-pk76snuy	116	9	five	five	CD
cord-016938-pk76snuy	116	10	samples	sample	NNS
cord-016938-pk76snuy	116	11	,	,	,
cord-016938-pk76snuy	116	12	*	*	NFP
cord-016938-pk76snuy	116	13	and	and	CC
cord-016938-pk76snuy	116	14	†	†	NN
cord-016938-pk76snuy	116	15	:	:	:
cord-016938-pk76snuy	116	16	significantly	significantly	RB
cord-016938-pk76snuy	116	17	different	different	JJ
cord-016938-pk76snuy	116	18	compared	compare	VBN
cord-016938-pk76snuy	116	19	to	to	IN
cord-016938-pk76snuy	116	20	the	the	DT
cord-016938-pk76snuy	116	21	control	control	NN
cord-016938-pk76snuy	116	22	non	non	JJ
cord-016938-pk76snuy	116	23	-	-	JJ
cord-016938-pk76snuy	116	24	treated	treated	JJ
cord-016938-pk76snuy	116	25	group	group	NN
cord-016938-pk76snuy	116	26	for	for	IN
cord-016938-pk76snuy	116	27	each	each	DT
cord-016938-pk76snuy	116	28	type	type	NN
cord-016938-pk76snuy	116	29	of	of	IN
cord-016938-pk76snuy	116	30	membrane	membrane	NN
cord-016938-pk76snuy	116	31	,	,	,
cord-016938-pk76snuy	116	32	*	*	NFP
cord-016938-pk76snuy	116	33	:	:	:
cord-016938-pk76snuy	116	34	p	p	NN
cord-016938-pk76snuy	116	35	<	<	XX
cord-016938-pk76snuy	116	36	0.05	0.05	CD
cord-016938-pk76snuy	116	37	and	and	CC
cord-016938-pk76snuy	116	38	†	†	NN
cord-016938-pk76snuy	116	39	:	:	:
cord-016938-pk76snuy	116	40	p	p	NN
cord-016938-pk76snuy	116	41	<	<	XX
cord-016938-pk76snuy	116	42	0.01	0.01	CD
cord-016938-pk76snuy	116	43	.	.	.
cord-016938-pk76snuy	117	1	CONTROL	control	NN
cord-016938-pk76snuy	117	2	:	:	:
cord-016938-pk76snuy	117	3	nontreated	nontreated	NNP
cord-016938-pk76snuy	117	4	group	group	NN
cord-016938-pk76snuy	117	5	,	,	,
cord-016938-pk76snuy	118	1	UV1/2	UV1/2	NNP
cord-016938-pk76snuy	118	2	:	:	:
cord-016938-pk76snuy	118	3	UV	uv	NN
cord-016938-pk76snuy	118	4	-	-	HYPH
cord-016938-pk76snuy	118	5	irradiated	irradiate	VBN
cord-016938-pk76snuy	118	6	group	group	NN
cord-016938-pk76snuy	118	7	for	for	IN
cord-016938-pk76snuy	118	8	30	30	CD
cord-016938-pk76snuy	118	9	mins	min	NNS
cord-016938-pk76snuy	118	10	,	,	,
cord-016938-pk76snuy	118	11	UV2	uv2	NN
cord-016938-pk76snuy	118	12	:	:	:
cord-016938-pk76snuy	118	13	UV	uv	NN
cord-016938-pk76snuy	118	14	-	-	HYPH
cord-016938-pk76snuy	118	15	irradiated	irradiate	VBN
cord-016938-pk76snuy	118	16	group	group	NN
cord-016938-pk76snuy	118	17	for	for	IN
cord-016938-pk76snuy	118	18	2	2	CD
cord-016938-pk76snuy	118	19	hours	hour	NNS
cord-016938-pk76snuy	118	20	,	,	,
cord-016938-pk76snuy	118	21	UV4	uv4	NN
cord-016938-pk76snuy	118	22	:	:	:
cord-016938-pk76snuy	118	23	UV	uv	NN
cord-016938-pk76snuy	118	24	-	-	HYPH
cord-016938-pk76snuy	118	25	irradiated	irradiate	VBN
cord-016938-pk76snuy	118	26	group	group	NN
cord-016938-pk76snuy	118	27	for	for	IN
cord-016938-pk76snuy	118	28	4	4	CD
cord-016938-pk76snuy	118	29	hours	hour	NNS
cord-016938-pk76snuy	118	30	,	,	,
cord-016938-pk76snuy	118	31	UV8	uv8	JJ
cord-016938-pk76snuy	118	32	:	:	:
cord-016938-pk76snuy	118	33	UV	uv	NN
cord-016938-pk76snuy	118	34	-	-	HYPH
cord-016938-pk76snuy	118	35	irradiated	irradiate	VBN
cord-016938-pk76snuy	118	36	group	group	NN
cord-016938-pk76snuy	118	37	for	for	IN
cord-016938-pk76snuy	118	38	8	8	CD
cord-016938-pk76snuy	118	39	hours	hour	NNS
cord-016938-pk76snuy	118	40	,	,	,
cord-016938-pk76snuy	118	41	GA	GA	NNP
cord-016938-pk76snuy	118	42	:	:	:
cord-016938-pk76snuy	118	43	0.625	0.625	CD
cord-016938-pk76snuy	118	44	%	%	NN
cord-016938-pk76snuy	118	45	glutaraldehyde	glutaraldehyde	NN
cord-016938-pk76snuy	118	46	pretreated	pretreate	VBN
cord-016938-pk76snuy	118	47	group	group	NN
cord-016938-pk76snuy	118	48	for	for	IN
cord-016938-pk76snuy	118	49	24	24	CD
cord-016938-pk76snuy	118	50	hours	hour	NNS
cord-016938-pk76snuy	118	51	(	(	-LRB-
cord-016938-pk76snuy	118	52	Y	Y	NNP
cord-016938-pk76snuy	118	53	-axis	-axis	NN
cord-016938-pk76snuy	118	54	:	:	:
cord-016938-pk76snuy	118	55	Maximum	maximum	JJ
cord-016938-pk76snuy	118	56	tensile	tensile	JJ
cord-016938-pk76snuy	118	57	stress	stress	NN
cord-016938-pk76snuy	118	58	(	(	-LRB-
cord-016938-pk76snuy	118	59	kPa	kPa	NNP
cord-016938-pk76snuy	118	60	)	)	-RRB-
cord-016938-pk76snuy	118	61	)	)	-RRB-
cord-016938-pk76snuy	118	62	provide	provide	VBP
cord-016938-pk76snuy	118	63	and/or	and/or	CC
cord-016938-pk76snuy	118	64	control	control	VB
cord-016938-pk76snuy	118	65	the	the	DT
cord-016938-pk76snuy	118	66	biological	biological	JJ
cord-016938-pk76snuy	118	67	function	function	NN
cord-016938-pk76snuy	118	68	of	of	IN
cord-016938-pk76snuy	118	69	the	the	DT
cord-016938-pk76snuy	118	70	collagen	collagen	NN
cord-016938-pk76snuy	118	71	can	can	MD
cord-016938-pk76snuy	118	72	be	be	VB
cord-016938-pk76snuy	118	73	introduced	introduce	VBN
cord-016938-pk76snuy	118	74	at	at	IN
cord-016938-pk76snuy	118	75	this	this	DT
cord-016938-pk76snuy	118	76	stage	stage	NN
cord-016938-pk76snuy	118	77	utilizing	utilize	VBG
cord-016938-pk76snuy	118	78	the	the	DT
cord-016938-pk76snuy	118	79	high	high	JJ
cord-016938-pk76snuy	118	80	viscosity	viscosity	NN
cord-016938-pk76snuy	118	81	property	property	NN
cord-016938-pk76snuy	118	82	.	.	.
cord-016938-pk76snuy	119	1	Biochemical	biochemical	JJ
cord-016938-pk76snuy	119	2	property	property	NN
cord-016938-pk76snuy	119	3	of	of	IN
cord-016938-pk76snuy	119	4	collagen	collagen	NN
cord-016938-pk76snuy	119	5	molecule	molecule	NN
cord-016938-pk76snuy	119	6	can	can	MD
cord-016938-pk76snuy	119	7	be	be	VB
cord-016938-pk76snuy	119	8	modified	modify	VBN
cord-016938-pk76snuy	119	9	by	by	IN
cord-016938-pk76snuy	119	10	varying	vary	VBG
cord-016938-pk76snuy	119	11	the	the	DT
cord-016938-pk76snuy	119	12	surface	surface	NN
cord-016938-pk76snuy	119	13	electric	electric	JJ
cord-016938-pk76snuy	119	14	charge	charge	NN
cord-016938-pk76snuy	119	15	by	by	IN
cord-016938-pk76snuy	119	16	altering	alter	VBG
cord-016938-pk76snuy	119	17	the	the	DT
cord-016938-pk76snuy	119	18	molecular	molecular	JJ
cord-016938-pk76snuy	119	19	side	side	NN
cord-016938-pk76snuy	119	20	chain	chain	NN
cord-016938-pk76snuy	119	21	which	which	WDT
cord-016938-pk76snuy	119	22	leads	lead	VBZ
cord-016938-pk76snuy	119	23	to	to	IN
cord-016938-pk76snuy	119	24	the	the	DT
cord-016938-pk76snuy	119	25	adjustment	adjustment	NN
cord-016938-pk76snuy	119	26	of	of	IN
cord-016938-pk76snuy	119	27	hydrophilicity	hydrophilicity	NN
cord-016938-pk76snuy	119	28	-	-	HYPH
cord-016938-pk76snuy	119	29	hydrophobicity	hydrophobicity	NN
cord-016938-pk76snuy	119	30	balance	balance	NN
cord-016938-pk76snuy	119	31	.	.	.
cord-016938-pk76snuy	120	1	Succinylization	Succinylization	NNP
cord-016938-pk76snuy	120	2	of	of	IN
cord-016938-pk76snuy	120	3	amines	amine	NNS
cord-016938-pk76snuy	120	4	(	(	-LRB-
cord-016938-pk76snuy	120	5	NH	NH	NNP
cord-016938-pk76snuy	120	6	-	-	HYPH
cord-016938-pk76snuy	120	7	CO(CH	CO(CH	NNP
cord-016938-pk76snuy	120	8	2	2	CD
cord-016938-pk76snuy	120	9	)	)	-RRB-
cord-016938-pk76snuy	120	10	2	2	CD
cord-016938-pk76snuy	120	11	-COOH	-COOH	.
cord-016938-pk76snuy	120	12	)	)	-RRB-
cord-016938-pk76snuy	120	13	by	by	IN
cord-016938-pk76snuy	120	14	using	use	VBG
cord-016938-pk76snuy	120	15	anhydrate	anhydrate	NNP
cord-016938-pk76snuy	120	16	succinyl	succinyl	NNP
cord-016938-pk76snuy	120	17	acid	acid	NNP
cord-016938-pk76snuy	120	18	provides	provide	VBZ
cord-016938-pk76snuy	120	19	abundant	abundant	JJ
cord-016938-pk76snuy	120	20	(	(	-LRB-
cord-016938-pk76snuy	120	21	−	−	NN
cord-016938-pk76snuy	120	22	)	)	-RRB-
cord-016938-pk76snuy	120	23	charges	charge	NNS
cord-016938-pk76snuy	120	24	,	,	,
cord-016938-pk76snuy	120	25	and	and	CC
cord-016938-pk76snuy	120	26	the	the	DT
cord-016938-pk76snuy	120	27	succinylated	succinylated	JJ
cord-016938-pk76snuy	120	28	collagen	collagen	NN
cord-016938-pk76snuy	120	29	becomes	become	VBZ
cord-016938-pk76snuy	120	30	soluble	soluble	JJ
cord-016938-pk76snuy	120	31	in	in	IN
cord-016938-pk76snuy	120	32	neutral	neutral	JJ
cord-016938-pk76snuy	120	33	solution	solution	NN
cord-016938-pk76snuy	120	34	,	,	,
cord-016938-pk76snuy	120	35	which	which	WDT
cord-016938-pk76snuy	120	36	finally	finally	RB
cord-016938-pk76snuy	120	37	results	result	VBZ
cord-016938-pk76snuy	120	38	in	in	IN
cord-016938-pk76snuy	120	39	translucent	translucent	JJ
cord-016938-pk76snuy	120	40	viscous	viscous	JJ
cord-016938-pk76snuy	120	41	collagen	collagen	NN
cord-016938-pk76snuy	120	42	gel	gel	NN
cord-016938-pk76snuy	120	43	with	with	IN
cord-016938-pk76snuy	120	44	hydrophilicity	hydrophilicity	NN
cord-016938-pk76snuy	120	45	.	.	.
cord-016938-pk76snuy	121	1	Meanwhile	meanwhile	RB
cord-016938-pk76snuy	121	2	esterization	esterization	NN
cord-016938-pk76snuy	121	3	(	(	-LRB-
cord-016938-pk76snuy	121	4	-COOCH	-COOCH	NNP
cord-016938-pk76snuy	121	5	3	3	LS
cord-016938-pk76snuy	121	6	)	)	-RRB-
cord-016938-pk76snuy	121	7	of	of	IN
cord-016938-pk76snuy	121	8	carboxyl	carboxyl	NN
cord-016938-pk76snuy	121	9	group	group	NN
cord-016938-pk76snuy	121	10	by	by	IN
cord-016938-pk76snuy	121	11	methanol	methanol	NN
cord-016938-pk76snuy	121	12	produces	produce	VBZ
cord-016938-pk76snuy	121	13	abundant	abundant	JJ
cord-016938-pk76snuy	121	14	(	(	-LRB-
cord-016938-pk76snuy	121	15	+	+	NNS
cord-016938-pk76snuy	121	16	)	)	-RRB-
cord-016938-pk76snuy	121	17	charges	charge	NNS
cord-016938-pk76snuy	121	18	on	on	IN
cord-016938-pk76snuy	121	19	the	the	DT
cord-016938-pk76snuy	121	20	collagen	collagen	NN
cord-016938-pk76snuy	121	21	and	and	CC
cord-016938-pk76snuy	121	22	provides	provide	VBZ
cord-016938-pk76snuy	121	23	a	a	DT
cord-016938-pk76snuy	121	24	favorable	favorable	JJ
cord-016938-pk76snuy	121	25	hydrophobic	hydrophobic	JJ
cord-016938-pk76snuy	121	26	niche	niche	NN
cord-016938-pk76snuy	121	27	for	for	IN
cord-016938-pk76snuy	121	28	protein	protein	NN
cord-016938-pk76snuy	121	29	adhesion	adhesion	NN
cord-016938-pk76snuy	121	30	.	.	.
cord-016938-pk76snuy	122	1	Atelocollagen	Atelocollagen	NNP
cord-016938-pk76snuy	122	2	gel	gel	NN
cord-016938-pk76snuy	122	3	is	be	VBZ
cord-016938-pk76snuy	122	4	fabricated	fabricate	VBN
cord-016938-pk76snuy	122	5	into	into	IN
cord-016938-pk76snuy	122	6	fiber	fiber	NN
cord-016938-pk76snuy	122	7	form	form	NN
cord-016938-pk76snuy	122	8	by	by	IN
cord-016938-pk76snuy	122	9	using	use	VBG
cord-016938-pk76snuy	122	10	an	an	DT
cord-016938-pk76snuy	122	11	electro	electro	JJ
cord-016938-pk76snuy	122	12	spinning	spinning	NN
cord-016938-pk76snuy	122	13	.	.	.
cord-016938-pk76snuy	123	1	For	for	IN
cord-016938-pk76snuy	123	2	example	example	NN
cord-016938-pk76snuy	123	3	,	,	,
cord-016938-pk76snuy	123	4	a	a	DT
cord-016938-pk76snuy	123	5	collagen	collagen	NN
cord-016938-pk76snuy	123	6	solution	solution	NN
cord-016938-pk76snuy	123	7	dissolved	dissolve	VBN
cord-016938-pk76snuy	123	8	in	in	IN
cord-016938-pk76snuy	123	9	1,1,1,3,3,3-hexafluoro-2-propanol	1,1,1,3,3,3-hexafluoro-2-propanol	CD
cord-016938-pk76snuy	123	10	(	(	-LRB-
cord-016938-pk76snuy	123	11	HFP	HFP	NNP
cord-016938-pk76snuy	123	12	)	)	-RRB-
cord-016938-pk76snuy	123	13	having	have	VBG
cord-016938-pk76snuy	123	14	concentration	concentration	NN
cord-016938-pk76snuy	123	15	over	over	IN
cord-016938-pk76snuy	123	16	5	5	CD
cord-016938-pk76snuy	123	17	%	%	NN
cord-016938-pk76snuy	123	18	is	be	VBZ
cord-016938-pk76snuy	123	19	useful	useful	JJ
cord-016938-pk76snuy	123	20	to	to	TO
cord-016938-pk76snuy	123	21	produce	produce	VB
cord-016938-pk76snuy	123	22	a	a	DT
cord-016938-pk76snuy	123	23	diameter	diameter	NN
cord-016938-pk76snuy	123	24	controlled	control	VBN
cord-016938-pk76snuy	123	25	nanofiber	nanofiber	NN
cord-016938-pk76snuy	123	26	by	by	IN
cord-016938-pk76snuy	123	27	passing	pass	VBG
cord-016938-pk76snuy	123	28	it	-PRON-	PRP
cord-016938-pk76snuy	123	29	through	through	IN
cord-016938-pk76snuy	123	30	a	a	DT
cord-016938-pk76snuy	123	31	diameter	diameter	NN
cord-016938-pk76snuy	123	32	adjustable	adjustable	JJ
cord-016938-pk76snuy	123	33	nozzle	nozzle	NN
cord-016938-pk76snuy	123	34	under	under	IN
cord-016938-pk76snuy	123	35	the	the	DT
cord-016938-pk76snuy	123	36	condition	condition	NN
cord-016938-pk76snuy	123	37	of	of	IN
cord-016938-pk76snuy	123	38	a	a	DT
cord-016938-pk76snuy	123	39	high	high	JJ
cord-016938-pk76snuy	123	40	voltage	voltage	NN
cord-016938-pk76snuy	123	41	at	at	IN
cord-016938-pk76snuy	123	42	25	25	CD
cord-016938-pk76snuy	123	43	kV	kV	NNP
cord-016938-pk76snuy	123	44	,	,	,
cord-016938-pk76snuy	123	45	flow	flow	NN
cord-016938-pk76snuy	123	46	velocity	velocity	NN
cord-016938-pk76snuy	123	47	at	at	IN
cord-016938-pk76snuy	123	48	2.5m	2.5m	CD
cord-016938-pk76snuy	123	49	/	/	SYM
cord-016938-pk76snuy	123	50	h	h	NN
cord-016938-pk76snuy	123	51	,	,	,
cord-016938-pk76snuy	123	52	metal	metal	NN
cord-016938-pk76snuy	123	53	collector	collector	NN
cord-016938-pk76snuy	123	54	of	of	IN
cord-016938-pk76snuy	123	55	2	2	CD
cord-016938-pk76snuy	123	56	cm	cm	NN
cord-016938-pk76snuy	123	57	width	width	NN
cord-016938-pk76snuy	123	58	with	with	IN
cord-016938-pk76snuy	123	59	rotating	rotate	VBG
cord-016938-pk76snuy	123	60	speed	speed	NN
cord-016938-pk76snuy	123	61	at	at	IN
cord-016938-pk76snuy	123	62	300	300	CD
cord-016938-pk76snuy	123	63	rpm	rpm	NN
cord-016938-pk76snuy	123	64	,	,	,
cord-016938-pk76snuy	123	65	and	and	CC
cord-016938-pk76snuy	123	66	distance	distance	NN
cord-016938-pk76snuy	123	67	between	between	IN
cord-016938-pk76snuy	123	68	the	the	DT
cord-016938-pk76snuy	123	69	metal	metal	NN
cord-016938-pk76snuy	123	70	collector	collector	NN
cord-016938-pk76snuy	123	71	and	and	CC
cord-016938-pk76snuy	123	72	spinner	spinner	NN
cord-016938-pk76snuy	123	73	of	of	IN
cord-016938-pk76snuy	123	74	15	15	CD
cord-016938-pk76snuy	123	75	cm	cm	NNS
cord-016938-pk76snuy	123	76	,	,	,
cord-016938-pk76snuy	123	77	and	and	CC
cord-016938-pk76snuy	123	78	finally	finally	RB
cord-016938-pk76snuy	123	79	removing	remove	VBG
cord-016938-pk76snuy	123	80	organic	organic	JJ
cord-016938-pk76snuy	123	81	solute	solute	NN
cord-016938-pk76snuy	123	82	for	for	IN
cord-016938-pk76snuy	123	83	48	48	CD
cord-016938-pk76snuy	123	84	hours	hour	NNS
cord-016938-pk76snuy	123	85	by	by	IN
cord-016938-pk76snuy	123	86	drying	dry	VBG
cord-016938-pk76snuy	123	87	in	in	IN
cord-016938-pk76snuy	123	88	a	a	DT
cord-016938-pk76snuy	123	89	vacuum	vacuum	NN
cord-016938-pk76snuy	123	90	chamber	chamber	NN
cord-016938-pk76snuy	123	91	.	.	.
cord-016938-pk76snuy	124	1	The	the	DT
cord-016938-pk76snuy	124	2	produced	produce	VBN
cord-016938-pk76snuy	124	3	nanofiber	nanofiber	NN
cord-016938-pk76snuy	124	4	is	be	VBZ
cord-016938-pk76snuy	124	5	crosslinked	crosslinke	VBN
cord-016938-pk76snuy	124	6	by	by	IN
cord-016938-pk76snuy	124	7	either	either	DT
cord-016938-pk76snuy	124	8	EDC	EDC	NNP
cord-016938-pk76snuy	124	9	or	or	CC
cord-016938-pk76snuy	124	10	UV	uv	NN
cord-016938-pk76snuy	124	11	irradiation	irradiation	NN
cord-016938-pk76snuy	124	12	later	later	RB
cord-016938-pk76snuy	124	13	in	in	IN
cord-016938-pk76snuy	124	14	order	order	NN
cord-016938-pk76snuy	124	15	to	to	TO
cord-016938-pk76snuy	124	16	reinforce	reinforce	VB
cord-016938-pk76snuy	124	17	the	the	DT
cord-016938-pk76snuy	124	18	fiber	fiber	NN
cord-016938-pk76snuy	124	19	strength	strength	NN
cord-016938-pk76snuy	124	20	,	,	,
cord-016938-pk76snuy	124	21	and	and	CC
cord-016938-pk76snuy	124	22	demonstrates	demonstrate	VBZ
cord-016938-pk76snuy	124	23	the	the	DT
cord-016938-pk76snuy	124	24	typical	typical	JJ
cord-016938-pk76snuy	124	25	triple	triple	JJ
cord-016938-pk76snuy	124	26	helical	helical	JJ
cord-016938-pk76snuy	124	27	structure	structure	NN
cord-016938-pk76snuy	124	28	of	of	IN
cord-016938-pk76snuy	124	29	collagen	collagen	NN
cord-016938-pk76snuy	124	30	molecule	molecule	NN
cord-016938-pk76snuy	124	31	.	.	.
cord-016938-pk76snuy	125	1	Freeze	freeze	NN
cord-016938-pk76snuy	125	2	-	-	HYPH
cord-016938-pk76snuy	125	3	drying	dry	VBG
cord-016938-pk76snuy	125	4	the	the	DT
cord-016938-pk76snuy	125	5	gel	gel	NN
cord-016938-pk76snuy	125	6	in	in	IN
cord-016938-pk76snuy	125	7	vacuum	vacuum	NN
cord-016938-pk76snuy	125	8	condition	condition	NN
cord-016938-pk76snuy	125	9	is	be	VBZ
cord-016938-pk76snuy	125	10	a	a	DT
cord-016938-pk76snuy	125	11	simple	simple	JJ
cord-016938-pk76snuy	125	12	procedure	procedure	NN
cord-016938-pk76snuy	125	13	for	for	IN
cord-016938-pk76snuy	125	14	fabrication	fabrication	NN
cord-016938-pk76snuy	125	15	of	of	IN
cord-016938-pk76snuy	125	16	a	a	DT
cord-016938-pk76snuy	125	17	porous	porous	JJ
cord-016938-pk76snuy	125	18	membrane	membrane	NN
cord-016938-pk76snuy	125	19	,	,	,
cord-016938-pk76snuy	125	20	as	as	IN
cord-016938-pk76snuy	125	21	lower	low	JJR
cord-016938-pk76snuy	125	22	concentration	concentration	NN
cord-016938-pk76snuy	125	23	and	and	CC
cord-016938-pk76snuy	125	24	higher	high	JJR
cord-016938-pk76snuy	125	25	freezing	freeze	VBG
cord-016938-pk76snuy	125	26	temperature	temperature	NN
cord-016938-pk76snuy	125	27	leads	lead	VBZ
cord-016938-pk76snuy	125	28	to	to	IN
cord-016938-pk76snuy	125	29	smaller	small	JJR
cord-016938-pk76snuy	125	30	and	and	CC
cord-016938-pk76snuy	125	31	bigger	big	JJR
cord-016938-pk76snuy	125	32	pores	pore	NNS
cord-016938-pk76snuy	125	33	[	[	-LRB-
cord-016938-pk76snuy	125	34	6	6	CD
cord-016938-pk76snuy	125	35	]	]	-RRB-
cord-016938-pk76snuy	125	36	[	[	-LRB-
cord-016938-pk76snuy	125	37	7	7	CD
cord-016938-pk76snuy	125	38	]	]	-RRB-
cord-016938-pk76snuy	126	1	[	[	-LRB-
cord-016938-pk76snuy	126	2	8	8	CD
cord-016938-pk76snuy	126	3	]	]	-RRB-
cord-016938-pk76snuy	126	4	[	[	-LRB-
cord-016938-pk76snuy	126	5	9	9	CD
cord-016938-pk76snuy	126	6	]	]	-RRB-
cord-016938-pk76snuy	126	7	[	[	-LRB-
cord-016938-pk76snuy	126	8	10	10	CD
cord-016938-pk76snuy	126	9	]	]	-RRB-
cord-016938-pk76snuy	126	10	,	,	,
cord-016938-pk76snuy	126	11	(	(	-LRB-
cord-016938-pk76snuy	126	12	Figs	fig	NNS
cord-016938-pk76snuy	126	13	.	.	.
cord-016938-pk76snuy	126	14	8.3	8.3	CD
cord-016938-pk76snuy	126	15	-	-	SYM
cord-016938-pk76snuy	126	16	8.8	8.8	CD
cord-016938-pk76snuy	126	17	)	)	-RRB-
cord-016938-pk76snuy	126	18	.	.	.
cord-016938-pk76snuy	126	19	 	 	_SP
cord-016938-pk76snuy	127	1	Collagen	collagen	NN
cord-016938-pk76snuy	127	2	contains	contain	VBZ
cord-016938-pk76snuy	127	3	much	much	JJ
cord-016938-pk76snuy	127	4	of	of	IN
cord-016938-pk76snuy	127	5	the	the	DT
cord-016938-pk76snuy	127	6	cell	cell	NN
cord-016938-pk76snuy	127	7	adhesive	adhesive	NN
cord-016938-pk76snuy	127	8	RGD	RGD	NNP
cord-016938-pk76snuy	127	9	sequences	sequence	NNS
cord-016938-pk76snuy	127	10	in	in	IN
cord-016938-pk76snuy	127	11	molecule	molecule	NN
cord-016938-pk76snuy	127	12	,	,	,
cord-016938-pk76snuy	127	13	thus	thus	RB
cord-016938-pk76snuy	127	14	has	have	VBZ
cord-016938-pk76snuy	127	15	cell	cell	NN
cord-016938-pk76snuy	127	16	conductive	conductive	JJ
cord-016938-pk76snuy	127	17	characteristics	characteristic	NNS
cord-016938-pk76snuy	127	18	and	and	CC
cord-016938-pk76snuy	127	19	is	be	VBZ
cord-016938-pk76snuy	127	20	applied	apply	VBN
cord-016938-pk76snuy	127	21	either	either	CC
cord-016938-pk76snuy	127	22	in	in	IN
cord-016938-pk76snuy	127	23	the	the	DT
cord-016938-pk76snuy	127	24	independent	independent	JJ
cord-016938-pk76snuy	127	25	form	form	NN
cord-016938-pk76snuy	127	26	,	,	,
cord-016938-pk76snuy	127	27	in	in	IN
cord-016938-pk76snuy	127	28	form	form	NN
cord-016938-pk76snuy	127	29	of	of	IN
cord-016938-pk76snuy	127	30	hybridization	hybridization	NN
cord-016938-pk76snuy	127	31	with	with	IN
cord-016938-pk76snuy	127	32	biofunctional	biofunctional	NNP
cord-016938-pk76snuy	127	33	agents	agent	NNS
cord-016938-pk76snuy	127	34	and	and	CC
cord-016938-pk76snuy	127	35	cells	cell	NNS
cord-016938-pk76snuy	127	36	,	,	,
cord-016938-pk76snuy	127	37	or	or	CC
cord-016938-pk76snuy	127	38	,	,	,
cord-016938-pk76snuy	127	39	occasionally	occasionally	RB
cord-016938-pk76snuy	127	40	,	,	,
cord-016938-pk76snuy	127	41	in	in	IN
cord-016938-pk76snuy	127	42	form	form	NN
cord-016938-pk76snuy	127	43	of	of	IN
cord-016938-pk76snuy	127	44	copolymer	copolymer	NN
cord-016938-pk76snuy	127	45	by	by	IN
cord-016938-pk76snuy	127	46	introduction	introduction	NN
cord-016938-pk76snuy	127	47	of	of	IN
cord-016938-pk76snuy	127	48	synthetic	synthetic	JJ
cord-016938-pk76snuy	127	49	polymers	polymer	NNS
cord-016938-pk76snuy	127	50	which	which	WDT
cord-016938-pk76snuy	127	51	is	be	VBZ
cord-016938-pk76snuy	127	52	mainly	mainly	RB
cord-016938-pk76snuy	127	53	aimed	aim	VBN
cord-016938-pk76snuy	127	54	to	to	TO
cord-016938-pk76snuy	127	55	enforce	enforce	VB
cord-016938-pk76snuy	127	56	mechanical	mechanical	JJ
cord-016938-pk76snuy	127	57	property	property	NN
cord-016938-pk76snuy	127	58	.	.	.
cord-016938-pk76snuy	128	1	Collagen	collagen	NN
cord-016938-pk76snuy	128	2	gel	gel	NN
cord-016938-pk76snuy	128	3	is	be	VBZ
cord-016938-pk76snuy	128	4	usually	usually	RB
cord-016938-pk76snuy	128	5	applied	apply	VBN
cord-016938-pk76snuy	128	6	to	to	IN
cord-016938-pk76snuy	128	7	cell	cell	NN
cord-016938-pk76snuy	128	8	culture	culture	NN
cord-016938-pk76snuy	128	9	.	.	.
cord-016938-pk76snuy	129	1	A	a	DT
cord-016938-pk76snuy	129	2	cell	cell	NN
cord-016938-pk76snuy	129	3	culture	culture	NN
cord-016938-pk76snuy	129	4	plate	plate	NN
cord-016938-pk76snuy	129	5	whose	whose	WP$
cord-016938-pk76snuy	129	6	bottom	bottom	NN
cord-016938-pk76snuy	129	7	surface	surface	NN
cord-016938-pk76snuy	129	8	is	be	VBZ
cord-016938-pk76snuy	129	9	coated	coat	VBN
cord-016938-pk76snuy	129	10	by	by	IN
cord-016938-pk76snuy	129	11	collagen	collagen	NN
cord-016938-pk76snuy	129	12	gel	gel	NN
cord-016938-pk76snuy	129	13	and	and	CC
cord-016938-pk76snuy	129	14	dried	dry	VBN
cord-016938-pk76snuy	129	15	makes	make	VBZ
cord-016938-pk76snuy	129	16	it	-PRON-	PRP
cord-016938-pk76snuy	129	17	possible	possible	JJ
cord-016938-pk76snuy	129	18	for	for	IN
cord-016938-pk76snuy	129	19	suspended	suspend	VBN
cord-016938-pk76snuy	129	20	cells	cell	NNS
cord-016938-pk76snuy	129	21	to	to	TO
cord-016938-pk76snuy	129	22	produce	produce	VB
cord-016938-pk76snuy	129	23	a	a	DT
cord-016938-pk76snuy	129	24	monolayered	monolayered	JJ
cord-016938-pk76snuy	129	25	cell	cell	NN
cord-016938-pk76snuy	129	26	cluster	cluster	NN
cord-016938-pk76snuy	129	27	by	by	IN
cord-016938-pk76snuy	129	28	attaching	attach	VBG
cord-016938-pk76snuy	129	29	them	-PRON-	PRP
cord-016938-pk76snuy	129	30	to	to	IN
cord-016938-pk76snuy	129	31	the	the	DT
cord-016938-pk76snuy	129	32	coated	coated	JJ
cord-016938-pk76snuy	129	33	collagen	collagen	NN
cord-016938-pk76snuy	129	34	layer	layer	NN
cord-016938-pk76snuy	129	35	.	.	.
cord-016938-pk76snuy	130	1	This	this	DT
cord-016938-pk76snuy	130	2	technique	technique	NN
cord-016938-pk76snuy	130	3	is	be	VBZ
cord-016938-pk76snuy	130	4	directly	directly	RB
cord-016938-pk76snuy	130	5	applied	apply	VBN
cord-016938-pk76snuy	130	6	to	to	TO
cord-016938-pk76snuy	130	7	produce	produce	VB
cord-016938-pk76snuy	130	8	skin	skin	NN
cord-016938-pk76snuy	130	9	wound	wound	NN
cord-016938-pk76snuy	130	10	dressing	dress	VBG
cord-016938-pk76snuy	130	11	membranes	membrane	NNS
cord-016938-pk76snuy	130	12	.	.	.
cord-016938-pk76snuy	131	1	Exposure	exposure	NN
cord-016938-pk76snuy	131	2	of	of	IN
cord-016938-pk76snuy	131	3	dermis	dermis	NN
cord-016938-pk76snuy	131	4	to	to	IN
cord-016938-pk76snuy	131	5	the	the	DT
cord-016938-pk76snuy	131	6	open	open	JJ
cord-016938-pk76snuy	131	7	air	air	NN
cord-016938-pk76snuy	131	8	,	,	,
cord-016938-pk76snuy	131	9	the	the	DT
cord-016938-pk76snuy	131	10	grade	grade	NN
cord-016938-pk76snuy	131	11	3	3	CD
cord-016938-pk76snuy	131	12	skin	skin	NN
cord-016938-pk76snuy	131	13	defect	defect	NN
cord-016938-pk76snuy	131	14	,	,	,
cord-016938-pk76snuy	131	15	in	in	IN
cord-016938-pk76snuy	131	16	which	which	WDT
cord-016938-pk76snuy	131	17	the	the	DT
cord-016938-pk76snuy	131	18	basal	basal	NN
cord-016938-pk76snuy	131	19	epithelial	epithelial	JJ
cord-016938-pk76snuy	131	20	layer	layer	NN
cord-016938-pk76snuy	131	21	that	that	WDT
cord-016938-pk76snuy	131	22	prevents	prevent	VBZ
cord-016938-pk76snuy	131	23	direct	direct	JJ
cord-016938-pk76snuy	131	24	contact	contact	NN
cord-016938-pk76snuy	131	25	of	of	IN
cord-016938-pk76snuy	131	26	inner	inner	JJ
cord-016938-pk76snuy	131	27	body	body	NN
cord-016938-pk76snuy	131	28	to	to	IN
cord-016938-pk76snuy	131	29	the	the	DT
cord-016938-pk76snuy	131	30	outer	outer	JJ
cord-016938-pk76snuy	131	31	bodily	bodily	JJ
cord-016938-pk76snuy	131	32	environment	environment	NN
cord-016938-pk76snuy	131	33	and	and	CC
cord-016938-pk76snuy	131	34	supports	support	VBZ
cord-016938-pk76snuy	131	35	epithelium	epithelium	NN
cord-016938-pk76snuy	131	36	as	as	IN
cord-016938-pk76snuy	131	37	the	the	DT
cord-016938-pk76snuy	131	38	bed	bed	NN
cord-016938-pk76snuy	131	39	for	for	IN
cord-016938-pk76snuy	131	40	keratinocytes	keratinocyte	NNS
cord-016938-pk76snuy	131	41	is	be	VBZ
cord-016938-pk76snuy	131	42	destroyed	destroy	VBN
cord-016938-pk76snuy	131	43	from	from	IN
cord-016938-pk76snuy	131	44	burn	burn	NN
cord-016938-pk76snuy	131	45	,	,	,
cord-016938-pk76snuy	131	46	and	and	CC
cord-016938-pk76snuy	131	47	sore	sore	JJ
cord-016938-pk76snuy	131	48	spots	spot	NNS
cord-016938-pk76snuy	131	49	induced	induce	VBN
cord-016938-pk76snuy	131	50	by	by	IN
cord-016938-pk76snuy	131	51	diabetes	diabetes	NN
cord-016938-pk76snuy	131	52	mellitus	mellitus	NN
cord-016938-pk76snuy	131	53	or	or	CC
cord-016938-pk76snuy	131	54	accident	accident	NN
cord-016938-pk76snuy	131	55	are	be	VBP
cord-016938-pk76snuy	131	56	critical	critical	JJ
cord-016938-pk76snuy	131	57	emergency	emergency	NN
cord-016938-pk76snuy	131	58	in	in	IN
cord-016938-pk76snuy	131	59	clinics	clinic	NNS
cord-016938-pk76snuy	131	60	.	.	.
cord-016938-pk76snuy	132	1	They	-PRON-	PRP
cord-016938-pk76snuy	132	2	evolve	evolve	VBP
cord-016938-pk76snuy	132	3	the	the	DT
cord-016938-pk76snuy	132	4	direct	direct	JJ
cord-016938-pk76snuy	132	5	contamination	contamination	NN
cord-016938-pk76snuy	132	6	of	of	IN
cord-016938-pk76snuy	132	7	dermis	dermis	NN
cord-016938-pk76snuy	132	8	which	which	WDT
cord-016938-pk76snuy	132	9	usually	usually	RB
cord-016938-pk76snuy	132	10	progresses	progress	VBZ
cord-016938-pk76snuy	132	11	toward	toward	IN
cord-016938-pk76snuy	132	12	fatal	fatal	JJ
cord-016938-pk76snuy	132	13	septicemia	septicemia	NN
cord-016938-pk76snuy	132	14	or	or	CC
cord-016938-pk76snuy	132	15	skin	skin	NN
cord-016938-pk76snuy	132	16	necrosis	necrosis	NN
cord-016938-pk76snuy	132	17	.	.	.
cord-016938-pk76snuy	133	1	The	the	DT
cord-016938-pk76snuy	133	2	conventional	conventional	JJ
cord-016938-pk76snuy	133	3	treatment	treatment	NN
cord-016938-pk76snuy	133	4	procedure	procedure	NN
cord-016938-pk76snuy	133	5	mainly	mainly	RB
cord-016938-pk76snuy	133	6	consists	consist	VBZ
cord-016938-pk76snuy	133	7	of	of	IN
cord-016938-pk76snuy	133	8	complete	complete	JJ
cord-016938-pk76snuy	133	9	irrigation	irrigation	NN
cord-016938-pk76snuy	133	10	and	and	CC
cord-016938-pk76snuy	133	11	debridement	debridement	NN
cord-016938-pk76snuy	133	12	of	of	IN
cord-016938-pk76snuy	133	13	the	the	DT
cord-016938-pk76snuy	133	14	wound	wound	NN
cord-016938-pk76snuy	133	15	,	,	,
cord-016938-pk76snuy	133	16	topical	topical	JJ
cord-016938-pk76snuy	133	17	administration	administration	NN
cord-016938-pk76snuy	133	18	of	of	IN
cord-016938-pk76snuy	133	19	broad	broad	JJ
cord-016938-pk76snuy	133	20	spectrum	spectrum	NN
cord-016938-pk76snuy	133	21	antibacterial	antibacterial	JJ
cord-016938-pk76snuy	133	22	and	and	CC
cord-016938-pk76snuy	133	23	antifungal	antifungal	JJ
cord-016938-pk76snuy	133	24	agents	agent	NNS
cord-016938-pk76snuy	133	25	,	,	,
cord-016938-pk76snuy	133	26	covering	cover	VBG
cord-016938-pk76snuy	133	27	the	the	DT
cord-016938-pk76snuy	133	28	wound	wound	NN
cord-016938-pk76snuy	133	29	by	by	IN
cord-016938-pk76snuy	133	30	oily	oily	JJ
cord-016938-pk76snuy	133	31	ointment	ointment	NN
cord-016938-pk76snuy	133	32	to	to	TO
cord-016938-pk76snuy	133	33	protect	protect	VB
cord-016938-pk76snuy	133	34	it	-PRON-	PRP
cord-016938-pk76snuy	133	35	from	from	IN
cord-016938-pk76snuy	133	36	air	air	NN
cord-016938-pk76snuy	133	37	contact	contact	NN
cord-016938-pk76snuy	133	38	,	,	,
cord-016938-pk76snuy	133	39	painful	painful	JJ
cord-016938-pk76snuy	133	40	daily	daily	JJ
cord-016938-pk76snuy	133	41	dressing	dressing	NN
cord-016938-pk76snuy	133	42	change	change	NN
cord-016938-pk76snuy	133	43	,	,	,
cord-016938-pk76snuy	133	44	and	and	CC
cord-016938-pk76snuy	133	45	observation	observation	NN
cord-016938-pk76snuy	133	46	of	of	IN
cord-016938-pk76snuy	133	47	the	the	DT
cord-016938-pk76snuy	133	48	auto	auto	NN
cord-016938-pk76snuy	133	49	-	-	HYPH
cord-016938-pk76snuy	133	50	regeneration	regeneration	NN
cord-016938-pk76snuy	133	51	of	of	IN
cord-016938-pk76snuy	133	52	wound	wound	NN
cord-016938-pk76snuy	133	53	by	by	IN
cord-016938-pk76snuy	133	54	proliferation	proliferation	NN
cord-016938-pk76snuy	133	55	of	of	IN
cord-016938-pk76snuy	133	56	both	both	DT
cord-016938-pk76snuy	133	57	dermal	dermal	JJ
cord-016938-pk76snuy	133	58	fibroblasts	fibroblast	NNS
cord-016938-pk76snuy	133	59	and	and	CC
cord-016938-pk76snuy	133	60	epithelial	epithelial	JJ
cord-016938-pk76snuy	133	61	keratinocytes	keratinocyte	NNS
cord-016938-pk76snuy	133	62	and	and	CC
cord-016938-pk76snuy	133	63	basement	basement	NN
cord-016938-pk76snuy	133	64	membrane	membrane	NN
cord-016938-pk76snuy	133	65	reconstruction	reconstruction	NN
cord-016938-pk76snuy	133	66	.	.	.
cord-016938-pk76snuy	134	1	Promoting	promote	VBG
cord-016938-pk76snuy	134	2	proliferation	proliferation	NN
cord-016938-pk76snuy	134	3	of	of	IN
cord-016938-pk76snuy	134	4	these	these	DT
cord-016938-pk76snuy	134	5	skin	skin	NN
cord-016938-pk76snuy	134	6	cells	cell	NNS
cord-016938-pk76snuy	134	7	with	with	IN
cord-016938-pk76snuy	134	8	protection	protection	NN
cord-016938-pk76snuy	134	9	from	from	IN
cord-016938-pk76snuy	134	10	air	air	NN
cord-016938-pk76snuy	134	11	contact	contact	NN
cord-016938-pk76snuy	134	12	until	until	IN
cord-016938-pk76snuy	134	13	complete	complete	JJ
cord-016938-pk76snuy	134	14	healing	healing	NN
cord-016938-pk76snuy	134	15	is	be	VBZ
cord-016938-pk76snuy	134	16	the	the	DT
cord-016938-pk76snuy	134	17	key	key	JJ
cord-016938-pk76snuy	134	18	technology	technology	NN
cord-016938-pk76snuy	134	19	,	,	,
cord-016938-pk76snuy	134	20	and	and	CC
cord-016938-pk76snuy	134	21	collagen	collagen	NN
cord-016938-pk76snuy	134	22	membrane	membrane	NN
cord-016938-pk76snuy	134	23	has	have	VBZ
cord-016938-pk76snuy	134	24	been	be	VBN
cord-016938-pk76snuy	134	25	applied	apply	VBN
cord-016938-pk76snuy	134	26	for	for	IN
cord-016938-pk76snuy	134	27	this	this	DT
cord-016938-pk76snuy	134	28	.	.	.
cord-016938-pk76snuy	135	1	For	for	IN
cord-016938-pk76snuy	135	2	example	example	NN
cord-016938-pk76snuy	135	3	,	,	,
cord-016938-pk76snuy	135	4	freeze	freeze	VB
cord-016938-pk76snuy	135	5	dried	dry	VBN
cord-016938-pk76snuy	135	6	atelocollagen	atelocollagen	NN
cord-016938-pk76snuy	135	7	in	in	IN
cord-016938-pk76snuy	135	8	vacuum	vacuum	NN
cord-016938-pk76snuy	135	9	forms	form	VBZ
cord-016938-pk76snuy	135	10	a	a	DT
cord-016938-pk76snuy	135	11	membrane	membrane	NN
cord-016938-pk76snuy	135	12	with	with	IN
cord-016938-pk76snuy	135	13	random	random	JJ
cord-016938-pk76snuy	135	14	pores	pore	NNS
cord-016938-pk76snuy	135	15	,	,	,
cord-016938-pk76snuy	135	16	and	and	CC
cord-016938-pk76snuy	135	17	the	the	DT
cord-016938-pk76snuy	135	18	pore	pore	NN
cord-016938-pk76snuy	135	19	size	size	NN
cord-016938-pk76snuy	135	20	into	into	IN
cord-016938-pk76snuy	135	21	which	which	WDT
cord-016938-pk76snuy	135	22	the	the	DT
cord-016938-pk76snuy	135	23	cells	cell	NNS
cord-016938-pk76snuy	135	24	may	may	MD
cord-016938-pk76snuy	135	25	proliferate	proliferate	VB
cord-016938-pk76snuy	135	26	is	be	VBZ
cord-016938-pk76snuy	135	27	controlled	control	VBN
cord-016938-pk76snuy	135	28	by	by	IN
cord-016938-pk76snuy	135	29	the	the	DT
cord-016938-pk76snuy	135	30	gel	gel	NN
cord-016938-pk76snuy	135	31	concentration	concentration	NN
cord-016938-pk76snuy	135	32	and	and	CC
cord-016938-pk76snuy	135	33	temperature	temperature	NN
cord-016938-pk76snuy	135	34	at	at	IN
cord-016938-pk76snuy	135	35	which	which	WDT
cord-016938-pk76snuy	135	36	it	-PRON-	PRP
cord-016938-pk76snuy	135	37	is	be	VBZ
cord-016938-pk76snuy	135	38	frozen	frozen	JJ
cord-016938-pk76snuy	135	39	.	.	.
cord-016938-pk76snuy	136	1	Freeze	freeze	NN
cord-016938-pk76snuy	136	2	dried	dry	VBD
cord-016938-pk76snuy	136	3	collagen	collagen	NN
cord-016938-pk76snuy	136	4	gel	gel	NN
cord-016938-pk76snuy	136	5	of	of	IN
cord-016938-pk76snuy	136	6	1	1	CD
cord-016938-pk76snuy	136	7	,	,	,
cord-016938-pk76snuy	136	8	2	2	CD
cord-016938-pk76snuy	136	9	,	,	,
cord-016938-pk76snuy	136	10	and	and	CC
cord-016938-pk76snuy	136	11	5	5	CD
cord-016938-pk76snuy	136	12	%	%	NN
cord-016938-pk76snuy	136	13	in	in	IN
cord-016938-pk76snuy	136	14	concentration	concentration	NN
cord-016938-pk76snuy	136	15	at	at	IN
cord-016938-pk76snuy	136	16	−20	−20	NNP
cord-016938-pk76snuy	136	17	,	,	,
cord-016938-pk76snuy	136	18	−40	−40	NNP
cord-016938-pk76snuy	136	19	,	,	,
cord-016938-pk76snuy	136	20	and	and	CC
cord-016938-pk76snuy	136	21	−80	−80	NNP
cord-016938-pk76snuy	137	1	•	•	NNP
cord-016938-pk76snuy	138	1	C	C	NNP
cord-016938-pk76snuy	138	2	for	for	IN
cord-016938-pk76snuy	138	3	1/2	1/2	CD
cord-016938-pk76snuy	138	4	,	,	,
cord-016938-pk76snuy	138	5	1	1	CD
cord-016938-pk76snuy	138	6	,	,	,
cord-016938-pk76snuy	138	7	2	2	CD
cord-016938-pk76snuy	138	8	,	,	,
cord-016938-pk76snuy	138	9	and	and	CC
cord-016938-pk76snuy	138	10	4	4	CD
cord-016938-pk76snuy	138	11	hours	hour	NNS
cord-016938-pk76snuy	138	12	demonstrated	demonstrate	VBD
cord-016938-pk76snuy	138	13	that	that	IN
cord-016938-pk76snuy	138	14	higher	high	JJR
cord-016938-pk76snuy	138	15	concentration	concentration	NN
cord-016938-pk76snuy	138	16	produced	produce	VBD
cord-016938-pk76snuy	138	17	less	less	JJR
cord-016938-pk76snuy	138	18	and	and	CC
cord-016938-pk76snuy	138	19	smaller	small	JJR
cord-016938-pk76snuy	138	20	sized	sized	JJ
cord-016938-pk76snuy	138	21	pores	pore	NNS
cord-016938-pk76snuy	138	22	.	.	.
cord-016938-pk76snuy	139	1	Also	also	RB
cord-016938-pk76snuy	139	2	,	,	,
cord-016938-pk76snuy	139	3	the	the	DT
cord-016938-pk76snuy	139	4	lower	low	JJR
cord-016938-pk76snuy	139	5	temperature	temperature	NN
cord-016938-pk76snuy	139	6	and	and	CC
cord-016938-pk76snuy	139	7	prolonged	prolong	VBN
cord-016938-pk76snuy	139	8	freezing	freezing	NN
cord-016938-pk76snuy	139	9	time	time	NN
cord-016938-pk76snuy	139	10	decreased	decrease	VBD
cord-016938-pk76snuy	139	11	viscosity	viscosity	NN
cord-016938-pk76snuy	139	12	.	.	.
cord-016938-pk76snuy	140	1	To	to	TO
cord-016938-pk76snuy	140	2	produce	produce	VB
cord-016938-pk76snuy	140	3	a	a	DT
cord-016938-pk76snuy	140	4	collagen	collagen	NN
cord-016938-pk76snuy	140	5	membrane	membrane	NN
cord-016938-pk76snuy	140	6	with	with	IN
cord-016938-pk76snuy	140	7	optimal	optimal	JJ
cord-016938-pk76snuy	140	8	pore	pore	NN
cord-016938-pk76snuy	140	9	size	size	NN
cord-016938-pk76snuy	140	10	of	of	IN
cord-016938-pk76snuy	140	11	over	over	IN
cord-016938-pk76snuy	140	12	120	120	CD
cord-016938-pk76snuy	140	13	μm	μm	NN
cord-016938-pk76snuy	140	14	which	which	WDT
cord-016938-pk76snuy	140	15	permits	permit	VBZ
cord-016938-pk76snuy	140	16	penetration	penetration	NN
cord-016938-pk76snuy	140	17	and	and	CC
cord-016938-pk76snuy	140	18	proliferation	proliferation	NN
cord-016938-pk76snuy	140	19	of	of	IN
cord-016938-pk76snuy	140	20	dermal	dermal	JJ
cord-016938-pk76snuy	140	21	fibroblast	fibroblast	NN
cord-016938-pk76snuy	140	22	proliferation	proliferation	NN
cord-016938-pk76snuy	140	23	,	,	,
cord-016938-pk76snuy	140	24	the	the	DT
cord-016938-pk76snuy	140	25	2	2	CD
cord-016938-pk76snuy	140	26	%	%	NN
cord-016938-pk76snuy	140	27	collagen	collagen	NN
cord-016938-pk76snuy	140	28	gel	gel	NN
cord-016938-pk76snuy	140	29	freeze	freeze	NN
cord-016938-pk76snuy	140	30	dried	dry	VBN
cord-016938-pk76snuy	140	31	at	at	IN
cord-016938-pk76snuy	140	32	−40	−40	NNP
cord-016938-pk76snuy	140	33	•	•	NNP
cord-016938-pk76snuy	140	34	C	C	NNP
cord-016938-pk76snuy	140	35	for	for	IN
cord-016938-pk76snuy	140	36	2	2	CD
cord-016938-pk76snuy	140	37	hours	hour	NNS
cord-016938-pk76snuy	140	38	and	and	CC
cord-016938-pk76snuy	140	39	crosslinked	crosslinke	VBN
cord-016938-pk76snuy	140	40	by	by	IN
cord-016938-pk76snuy	140	41	EDC	EDC	NNP
cord-016938-pk76snuy	140	42	or	or	CC
cord-016938-pk76snuy	140	43	UV	uv	NN
cord-016938-pk76snuy	140	44	irradiation	irradiation	NN
cord-016938-pk76snuy	140	45	for	for	IN
cord-016938-pk76snuy	140	46	2	2	CD
cord-016938-pk76snuy	140	47	hours	hour	NNS
cord-016938-pk76snuy	140	48	was	be	VBD
cord-016938-pk76snuy	140	49	found	find	VBN
cord-016938-pk76snuy	140	50	to	to	TO
cord-016938-pk76snuy	140	51	be	be	VB
cord-016938-pk76snuy	140	52	recommendable	recommendable	JJ
cord-016938-pk76snuy	140	53	to	to	TO
cord-016938-pk76snuy	140	54	use	use	VB
cord-016938-pk76snuy	140	55	as	as	IN
cord-016938-pk76snuy	140	56	a	a	DT
cord-016938-pk76snuy	140	57	dermal	dermal	JJ
cord-016938-pk76snuy	140	58	cell	cell	NN
cord-016938-pk76snuy	140	59	conductive	conductive	JJ
cord-016938-pk76snuy	140	60	membrane	membrane	NN
cord-016938-pk76snuy	140	61	that	that	WDT
cord-016938-pk76snuy	140	62	provides	provide	VBZ
cord-016938-pk76snuy	140	63	the	the	DT
cord-016938-pk76snuy	140	64	appropriate	appropriate	JJ
cord-016938-pk76snuy	140	65	viscosity	viscosity	NN
cord-016938-pk76snuy	140	66	for	for	IN
cord-016938-pk76snuy	140	67	initial	initial	JJ
cord-016938-pk76snuy	140	68	anchorage	anchorage	NN
cord-016938-pk76snuy	140	69	,	,	,
cord-016938-pk76snuy	140	70	and	and	CC
cord-016938-pk76snuy	140	71	any	any	DT
cord-016938-pk76snuy	140	72	inflammatory	inflammatory	JJ
cord-016938-pk76snuy	140	73	exudate	exudate	NN
cord-016938-pk76snuy	140	74	escapes	escape	VBZ
cord-016938-pk76snuy	140	75	through	through	IN
cord-016938-pk76snuy	140	76	pores	pore	NNS
cord-016938-pk76snuy	140	77	.	.	.
cord-016938-pk76snuy	141	1	A	a	DT
cord-016938-pk76snuy	141	2	collagen	collagen	NN
cord-016938-pk76snuy	141	3	bi	bi	JJ
cord-016938-pk76snuy	141	4	-	-	JJ
cord-016938-pk76snuy	141	5	layered	layered	JJ
cord-016938-pk76snuy	141	6	membrane	membrane	NN
cord-016938-pk76snuy	141	7	is	be	VBZ
cord-016938-pk76snuy	141	8	applied	apply	VBN
cord-016938-pk76snuy	141	9	to	to	IN
cord-016938-pk76snuy	141	10	skin	skin	NN
cord-016938-pk76snuy	141	11	in	in	IN
cord-016938-pk76snuy	141	12	forms	form	NNS
cord-016938-pk76snuy	141	13	of	of	IN
cord-016938-pk76snuy	141	14	either	either	CC
cord-016938-pk76snuy	141	15	wound	wound	NN
cord-016938-pk76snuy	141	16	dressing	dressing	NN
cord-016938-pk76snuy	141	17	or	or	CC
cord-016938-pk76snuy	141	18	extracellular	extracellular	JJ
cord-016938-pk76snuy	141	19	structural	structural	JJ
cord-016938-pk76snuy	141	20	supporting	support	VBG
cord-016938-pk76snuy	141	21	matrix	matrix	NN
cord-016938-pk76snuy	141	22	for	for	IN
cord-016938-pk76snuy	141	23	artificial	artificial	JJ
cord-016938-pk76snuy	141	24	skin	skin	NN
cord-016938-pk76snuy	141	25	.	.	.
cord-016938-pk76snuy	142	1	Laminin	Laminin	NNP
cord-016938-pk76snuy	142	2	,	,	,
cord-016938-pk76snuy	142	3	which	which	WDT
cord-016938-pk76snuy	142	4	is	be	VBZ
cord-016938-pk76snuy	142	5	a	a	DT
cord-016938-pk76snuy	142	6	cell	cell	NN
cord-016938-pk76snuy	142	7	adhesive	adhesive	NN
cord-016938-pk76snuy	142	8	protein	protein	NN
cord-016938-pk76snuy	142	9	and	and	CC
cord-016938-pk76snuy	142	10	a	a	DT
cord-016938-pk76snuy	142	11	main	main	JJ
cord-016938-pk76snuy	142	12	component	component	NN
cord-016938-pk76snuy	142	13	of	of	IN
cord-016938-pk76snuy	142	14	the	the	DT
cord-016938-pk76snuy	142	15	basement	basement	NN
cord-016938-pk76snuy	142	16	membrane	membrane	NN
cord-016938-pk76snuy	142	17	between	between	IN
cord-016938-pk76snuy	142	18	dermis	dermis	NN
cord-016938-pk76snuy	142	19	and	and	CC
cord-016938-pk76snuy	142	20	epithelium	epithelium	NN
cord-016938-pk76snuy	142	21	,	,	,
cord-016938-pk76snuy	142	22	is	be	VBZ
cord-016938-pk76snuy	142	23	mixed	mix	VBN
cord-016938-pk76snuy	142	24	with	with	IN
cord-016938-pk76snuy	142	25	2	2	CD
cord-016938-pk76snuy	142	26	%	%	NN
cord-016938-pk76snuy	142	27	collagen	collagen	NN
cord-016938-pk76snuy	142	28	gel	gel	NN
cord-016938-pk76snuy	142	29	.	.	.
cord-016938-pk76snuy	143	1	A	a	DT
cord-016938-pk76snuy	143	2	porous	porous	JJ
cord-016938-pk76snuy	143	3	collagenlaminin	collagenlaminin	NNS
cord-016938-pk76snuy	143	4	membrane	membrane	NN
cord-016938-pk76snuy	143	5	is	be	VBZ
cord-016938-pk76snuy	143	6	fabricated	fabricate	VBN
cord-016938-pk76snuy	143	7	and	and	CC
cord-016938-pk76snuy	143	8	freeze	freeze	NN
cord-016938-pk76snuy	143	9	-	-	HYPH
cord-016938-pk76snuy	143	10	dried	dry	VBN
cord-016938-pk76snuy	143	11	as	as	IN
cord-016938-pk76snuy	143	12	previously	previously	RB
cord-016938-pk76snuy	143	13	described	describe	VBN
cord-016938-pk76snuy	143	14	and	and	CC
cord-016938-pk76snuy	143	15	additional	additional	JJ
cord-016938-pk76snuy	143	16	4	4	CD
cord-016938-pk76snuy	143	17	%	%	NN
cord-016938-pk76snuy	143	18	collagen	collagen	NN
cord-016938-pk76snuy	143	19	gel	gel	NN
cord-016938-pk76snuy	143	20	is	be	VBZ
cord-016938-pk76snuy	143	21	coated	coat	VBN
cord-016938-pk76snuy	143	22	on	on	IN
cord-016938-pk76snuy	143	23	the	the	DT
cord-016938-pk76snuy	143	24	porous	porous	JJ
cord-016938-pk76snuy	143	25	membrane	membrane	NN
cord-016938-pk76snuy	143	26	and	and	CC
cord-016938-pk76snuy	143	27	crosslinking	crosslinking	NN
cord-016938-pk76snuy	143	28	is	be	VBZ
cord-016938-pk76snuy	143	29	promoted	promote	VBN
cord-016938-pk76snuy	143	30	by	by	IN
cord-016938-pk76snuy	143	31	EDC	EDC	NNP
cord-016938-pk76snuy	143	32	treatment	treatment	NN
cord-016938-pk76snuy	143	33	or	or	CC
cord-016938-pk76snuy	143	34	UV	uv	NN
cord-016938-pk76snuy	143	35	irradiation	irradiation	NN
cord-016938-pk76snuy	143	36	.	.	.
cord-016938-pk76snuy	144	1	Through	through	IN
cord-016938-pk76snuy	144	2	this	this	DT
cord-016938-pk76snuy	144	3	procedure	procedure	NN
cord-016938-pk76snuy	144	4	,	,	,
cord-016938-pk76snuy	144	5	a	a	DT
cord-016938-pk76snuy	144	6	bi	bi	JJ
cord-016938-pk76snuy	144	7	-	-	JJ
cord-016938-pk76snuy	144	8	layered	layered	JJ
cord-016938-pk76snuy	144	9	collagen	collagen	NN
cord-016938-pk76snuy	144	10	matrix	matrix	NN
cord-016938-pk76snuy	144	11	that	that	WDT
cord-016938-pk76snuy	144	12	consists	consist	VBZ
cord-016938-pk76snuy	144	13	of	of	IN
cord-016938-pk76snuy	144	14	dense	dense	JJ
cord-016938-pk76snuy	144	15	collagen	collagen	NN
cord-016938-pk76snuy	144	16	layer	layer	NN
cord-016938-pk76snuy	144	17	overlaid	overlay	VBN
cord-016938-pk76snuy	144	18	on	on	IN
cord-016938-pk76snuy	144	19	the	the	DT
cord-016938-pk76snuy	144	20	prefabricated	prefabricated	JJ
cord-016938-pk76snuy	144	21	porous	porous	JJ
cord-016938-pk76snuy	144	22	collagen	collagen	NN
cord-016938-pk76snuy	144	23	-	-	HYPH
cord-016938-pk76snuy	144	24	laminin	laminin	NN
cord-016938-pk76snuy	144	25	membrane	membrane	NN
cord-016938-pk76snuy	144	26	was	be	VBD
cord-016938-pk76snuy	144	27	produced	produce	VBN
cord-016938-pk76snuy	144	28	.	.	.
cord-016938-pk76snuy	145	1	In	in	IN
cord-016938-pk76snuy	145	2	use	use	NN
cord-016938-pk76snuy	145	3	as	as	IN
cord-016938-pk76snuy	145	4	a	a	DT
cord-016938-pk76snuy	145	5	wound	wound	NN
cord-016938-pk76snuy	145	6	dressing	dressing	NN
cord-016938-pk76snuy	145	7	,	,	,
cord-016938-pk76snuy	145	8	the	the	DT
cord-016938-pk76snuy	145	9	upper	upper	JJ
cord-016938-pk76snuy	145	10	dense	dense	JJ
cord-016938-pk76snuy	145	11	layer	layer	NN
cord-016938-pk76snuy	145	12	prohibits	prohibit	VBZ
cord-016938-pk76snuy	145	13	direct	direct	JJ
cord-016938-pk76snuy	145	14	wound	wound	NN
cord-016938-pk76snuy	145	15	contact	contact	NN
cord-016938-pk76snuy	145	16	with	with	IN
cord-016938-pk76snuy	145	17	the	the	DT
cord-016938-pk76snuy	145	18	open	open	JJ
cord-016938-pk76snuy	145	19	air	air	NN
cord-016938-pk76snuy	145	20	and	and	CC
cord-016938-pk76snuy	145	21	plays	play	VBZ
cord-016938-pk76snuy	145	22	a	a	DT
cord-016938-pk76snuy	145	23	role	role	NN
cord-016938-pk76snuy	145	24	as	as	IN
cord-016938-pk76snuy	145	25	a	a	DT
cord-016938-pk76snuy	145	26	bed	bed	NN
cord-016938-pk76snuy	145	27	for	for	IN
cord-016938-pk76snuy	145	28	keratinocyte	keratinocyte	NNP
cord-016938-pk76snuy	145	29	proliferation	proliferation	NN
cord-016938-pk76snuy	145	30	,	,	,
cord-016938-pk76snuy	145	31	while	while	IN
cord-016938-pk76snuy	145	32	the	the	DT
cord-016938-pk76snuy	145	33	porous	porous	JJ
cord-016938-pk76snuy	145	34	layer	layer	NN
cord-016938-pk76snuy	145	35	conducts	conduct	VBZ
cord-016938-pk76snuy	145	36	dermal	dermal	JJ
cord-016938-pk76snuy	145	37	fibroblast	fibroblast	NN
cord-016938-pk76snuy	145	38	proliferation	proliferation	NN
cord-016938-pk76snuy	145	39	.	.	.
cord-016938-pk76snuy	146	1	Thus	thus	RB
cord-016938-pk76snuy	146	2	,	,	,
cord-016938-pk76snuy	146	3	the	the	DT
cord-016938-pk76snuy	146	4	painful	painful	JJ
cord-016938-pk76snuy	146	5	daily	daily	JJ
cord-016938-pk76snuy	146	6	dressing	dressing	NN
cord-016938-pk76snuy	146	7	change	change	NN
cord-016938-pk76snuy	146	8	becomes	become	VBZ
cord-016938-pk76snuy	146	9	unnecessary	unnecessary	JJ
cord-016938-pk76snuy	146	10	.	.	.
cord-016938-pk76snuy	147	1	Antibacterial	antibacterial	JJ
cord-016938-pk76snuy	147	2	agents	agent	NNS
cord-016938-pk76snuy	147	3	encapsulated	encapsulate	VBN
cord-016938-pk76snuy	147	4	by	by	IN
cord-016938-pk76snuy	147	5	hyaluronic	hyaluronic	NN
cord-016938-pk76snuy	147	6	acid	acid	NN
cord-016938-pk76snuy	147	7	can	can	MD
cord-016938-pk76snuy	147	8	be	be	VB
cord-016938-pk76snuy	147	9	incorporated	incorporate	VBN
cord-016938-pk76snuy	147	10	into	into	IN
cord-016938-pk76snuy	147	11	the	the	DT
cord-016938-pk76snuy	147	12	collagen	collagen	NN
cord-016938-pk76snuy	147	13	gel	gel	NN
cord-016938-pk76snuy	147	14	and	and	CC
cord-016938-pk76snuy	147	15	the	the	DT
cord-016938-pk76snuy	147	16	drug	drug	NN
cord-016938-pk76snuy	147	17	may	may	MD
cord-016938-pk76snuy	147	18	be	be	VB
cord-016938-pk76snuy	147	19	released	release	VBN
cord-016938-pk76snuy	147	20	from	from	IN
cord-016938-pk76snuy	147	21	the	the	DT
cord-016938-pk76snuy	147	22	collagen	collagen	NN
cord-016938-pk76snuy	147	23	membrane	membrane	NN
cord-016938-pk76snuy	147	24	to	to	TO
cord-016938-pk76snuy	147	25	avoid	avoid	VB
cord-016938-pk76snuy	147	26	periodic	periodic	JJ
cord-016938-pk76snuy	147	27	topical	topical	JJ
cord-016938-pk76snuy	147	28	drug	drug	NN
cord-016938-pk76snuy	147	29	application	application	NN
cord-016938-pk76snuy	147	30	.	.	.
cord-016938-pk76snuy	148	1	Fabrication	fabrication	NN
cord-016938-pk76snuy	148	2	of	of	IN
cord-016938-pk76snuy	148	3	the	the	DT
cord-016938-pk76snuy	148	4	bi	bi	JJ
cord-016938-pk76snuy	148	5	-	-	JJ
cord-016938-pk76snuy	148	6	layered	layered	JJ
cord-016938-pk76snuy	148	7	collagen	collagen	NN
cord-016938-pk76snuy	148	8	membrane	membrane	NN
cord-016938-pk76snuy	148	9	is	be	VBZ
cord-016938-pk76snuy	148	10	the	the	DT
cord-016938-pk76snuy	148	11	basic	basic	JJ
cord-016938-pk76snuy	148	12	technology	technology	NN
cord-016938-pk76snuy	148	13	applicable	applicable	JJ
cord-016938-pk76snuy	148	14	to	to	TO
cord-016938-pk76snuy	148	15	manufacture	manufacture	VB
cord-016938-pk76snuy	148	16	of	of	IN
cord-016938-pk76snuy	148	17	artificial	artificial	JJ
cord-016938-pk76snuy	148	18	skin	skin	NN
cord-016938-pk76snuy	148	19	.	.	.
cord-016938-pk76snuy	149	1	In	in	IN
cord-016938-pk76snuy	149	2	the	the	DT
cord-016938-pk76snuy	149	3	1980s	1980	NNS
cord-016938-pk76snuy	149	4	,	,	,
cord-016938-pk76snuy	149	5	Bell	Bell	NNP
cord-016938-pk76snuy	149	6	introduced	introduce	VBD
cord-016938-pk76snuy	149	7	a	a	DT
cord-016938-pk76snuy	149	8	method	method	NN
cord-016938-pk76snuy	149	9	in	in	IN
cord-016938-pk76snuy	149	10	Fig	Fig	NNP
cord-016938-pk76snuy	149	11	.	.	.
cord-016938-pk76snuy	150	1	8.9	8.9	CD
cord-016938-pk76snuy	150	2	Collagen	Collagen	NNP
cord-016938-pk76snuy	150	3	-	-	HYPH
cord-016938-pk76snuy	150	4	Laminin	Laminin	NNP
cord-016938-pk76snuy	150	5	hybridized	hybridize	VBD
cord-016938-pk76snuy	150	6	porous	porous	JJ
cord-016938-pk76snuy	150	7	membrane	membrane	NN
cord-016938-pk76snuy	150	8	for	for	IN
cord-016938-pk76snuy	150	9	dermis	dermis	NN
cord-016938-pk76snuy	150	10	which	which	WDT
cord-016938-pk76snuy	150	11	dermal	dermal	JJ
cord-016938-pk76snuy	150	12	fibroblasts	fibroblast	NNS
cord-016938-pk76snuy	150	13	and	and	CC
cord-016938-pk76snuy	150	14	collagen	collagen	NN
cord-016938-pk76snuy	150	15	gel	gel	NN
cord-016938-pk76snuy	150	16	mixture	mixture	NN
cord-016938-pk76snuy	150	17	were	be	VBD
cord-016938-pk76snuy	150	18	cultured	culture	VBN
cord-016938-pk76snuy	150	19	at	at	IN
cord-016938-pk76snuy	150	20	37	37	CD
cord-016938-pk76snuy	150	21	•	•	NN
cord-016938-pk76snuy	150	22	C	C	NNP
cord-016938-pk76snuy	150	23	,	,	,
cord-016938-pk76snuy	150	24	and	and	CC
cord-016938-pk76snuy	150	25	when	when	WRB
cord-016938-pk76snuy	150	26	the	the	DT
cord-016938-pk76snuy	150	27	cells	cell	NNS
cord-016938-pk76snuy	150	28	were	be	VBD
cord-016938-pk76snuy	150	29	confluent	confluent	JJ
cord-016938-pk76snuy	150	30	in	in	IN
cord-016938-pk76snuy	150	31	the	the	DT
cord-016938-pk76snuy	150	32	gradually	gradually	RB
cord-016938-pk76snuy	150	33	shrinked	shrink	VBN
cord-016938-pk76snuy	150	34	gel	gel	NN
cord-016938-pk76snuy	150	35	,	,	,
cord-016938-pk76snuy	150	36	the	the	DT
cord-016938-pk76snuy	150	37	collagen	collagen	NN
cord-016938-pk76snuy	150	38	-	-	HYPH
cord-016938-pk76snuy	150	39	fibroblast	fibroblast	NN
cord-016938-pk76snuy	150	40	composite	composite	NN
cord-016938-pk76snuy	150	41	is	be	VBZ
cord-016938-pk76snuy	150	42	produced	produce	VBN
cord-016938-pk76snuy	150	43	.	.	.
cord-016938-pk76snuy	151	1	Keratinocytes	keratinocyte	NNS
cord-016938-pk76snuy	151	2	were	be	VBD
cord-016938-pk76snuy	151	3	overlaid	overlay	VBN
cord-016938-pk76snuy	151	4	on	on	IN
cord-016938-pk76snuy	151	5	the	the	DT
cord-016938-pk76snuy	151	6	composite	composite	NN
cord-016938-pk76snuy	151	7	to	to	TO
cord-016938-pk76snuy	151	8	mimic	mimic	VB
cord-016938-pk76snuy	151	9	anatomy	anatomy	NN
cord-016938-pk76snuy	151	10	of	of	IN
cord-016938-pk76snuy	151	11	the	the	DT
cord-016938-pk76snuy	151	12	dermal	dermal	JJ
cord-016938-pk76snuy	151	13	cellular	cellular	JJ
cord-016938-pk76snuy	151	14	structure	structure	NN
cord-016938-pk76snuy	151	15	,	,	,
cord-016938-pk76snuy	151	16	but	but	CC
cord-016938-pk76snuy	151	17	it	-PRON-	PRP
cord-016938-pk76snuy	151	18	required	require	VBD
cord-016938-pk76snuy	151	19	about	about	RB
cord-016938-pk76snuy	151	20	20	20	CD
cord-016938-pk76snuy	151	21	days	day	NNS
cord-016938-pk76snuy	151	22	for	for	IN
cord-016938-pk76snuy	151	23	the	the	DT
cord-016938-pk76snuy	151	24	manufacture	manufacture	NN
cord-016938-pk76snuy	151	25	to	to	TO
cord-016938-pk76snuy	151	26	be	be	VB
cord-016938-pk76snuy	151	27	completed	complete	VBN
cord-016938-pk76snuy	151	28	and	and	CC
cord-016938-pk76snuy	151	29	it	-PRON-	PRP
cord-016938-pk76snuy	151	30	was	be	VBD
cord-016938-pk76snuy	151	31	therefore	therefore	RB
cord-016938-pk76snuy	151	32	not	not	RB
cord-016938-pk76snuy	151	33	applicable	applicable	JJ
cord-016938-pk76snuy	151	34	to	to	IN
cord-016938-pk76snuy	151	35	patients	patient	NNS
cord-016938-pk76snuy	151	36	with	with	IN
cord-016938-pk76snuy	151	37	grade	grade	NN
cord-016938-pk76snuy	151	38	3	3	CD
cord-016938-pk76snuy	151	39	skin	skin	NN
cord-016938-pk76snuy	151	40	wound	wound	NN
cord-016938-pk76snuy	151	41	.	.	.
cord-016938-pk76snuy	152	1	On	on	IN
cord-016938-pk76snuy	152	2	the	the	DT
cord-016938-pk76snuy	152	3	other	other	JJ
cord-016938-pk76snuy	152	4	hand	hand	NN
cord-016938-pk76snuy	152	5	,	,	,
cord-016938-pk76snuy	152	6	Green	Green	NNP
cord-016938-pk76snuy	152	7	introduced	introduce	VBD
cord-016938-pk76snuy	152	8	an	an	DT
cord-016938-pk76snuy	152	9	advanced	advanced	JJ
cord-016938-pk76snuy	152	10	method	method	NN
cord-016938-pk76snuy	152	11	in	in	IN
cord-016938-pk76snuy	152	12	which	which	WDT
cord-016938-pk76snuy	152	13	dermal	dermal	JJ
cord-016938-pk76snuy	152	14	fibroblasts	fibroblast	NNS
cord-016938-pk76snuy	152	15	were	be	VBD
cord-016938-pk76snuy	152	16	cultured	culture	VBN
cord-016938-pk76snuy	152	17	to	to	TO
cord-016938-pk76snuy	152	18	form	form	VB
cord-016938-pk76snuy	152	19	monolayer	monolayer	NN
cord-016938-pk76snuy	152	20	on	on	IN
cord-016938-pk76snuy	152	21	a	a	DT
cord-016938-pk76snuy	152	22	collagen	collagen	NN
cord-016938-pk76snuy	152	23	coated	coated	JJ
cord-016938-pk76snuy	152	24	culture	culture	NN
cord-016938-pk76snuy	152	25	plate	plate	NN
cord-016938-pk76snuy	152	26	and	and	CC
cord-016938-pk76snuy	152	27	then	then	RB
cord-016938-pk76snuy	152	28	keratinocyte	keratinocyte	NNP
cord-016938-pk76snuy	152	29	was	be	VBD
cord-016938-pk76snuy	152	30	directly	directly	RB
cord-016938-pk76snuy	152	31	co	co	JJ
cord-016938-pk76snuy	152	32	-	-	JJ
cord-016938-pk76snuy	152	33	cultured	cultured	JJ
cord-016938-pk76snuy	152	34	on	on	IN
cord-016938-pk76snuy	152	35	the	the	DT
cord-016938-pk76snuy	152	36	fibroblast	fibroblast	NN
cord-016938-pk76snuy	152	37	monolayer	monolayer	NN
cord-016938-pk76snuy	152	38	in	in	IN
cord-016938-pk76snuy	152	39	a	a	DT
cord-016938-pk76snuy	152	40	media	medium	NNS
cord-016938-pk76snuy	152	41	containing	contain	VBG
cord-016938-pk76snuy	152	42	epithelial	epithelial	JJ
cord-016938-pk76snuy	152	43	growth	growth	NN
cord-016938-pk76snuy	152	44	factor	factor	NN
cord-016938-pk76snuy	152	45	.	.	.
cord-016938-pk76snuy	153	1	Nonetheless	nonetheless	RB
cord-016938-pk76snuy	153	2	,	,	,
cord-016938-pk76snuy	153	3	this	this	DT
cord-016938-pk76snuy	153	4	method	method	NN
cord-016938-pk76snuy	153	5	still	still	RB
cord-016938-pk76snuy	153	6	required	require	VBN
cord-016938-pk76snuy	153	7	at	at	IN
cord-016938-pk76snuy	153	8	least	least	JJS
cord-016938-pk76snuy	153	9	a	a	DT
cord-016938-pk76snuy	153	10	week	week	NN
cord-016938-pk76snuy	153	11	for	for	IN
cord-016938-pk76snuy	153	12	the	the	DT
cord-016938-pk76snuy	153	13	complete	complete	JJ
cord-016938-pk76snuy	153	14	fabrication	fabrication	NN
cord-016938-pk76snuy	153	15	,	,	,
cord-016938-pk76snuy	153	16	and	and	CC
cord-016938-pk76snuy	153	17	employment	employment	NN
cord-016938-pk76snuy	153	18	of	of	IN
cord-016938-pk76snuy	153	19	growth	growth	NN
cord-016938-pk76snuy	153	20	factors	factor	NNS
cord-016938-pk76snuy	153	21	holds	hold	VBZ
cord-016938-pk76snuy	153	22	a	a	DT
cord-016938-pk76snuy	153	23	risk	risk	NN
cord-016938-pk76snuy	153	24	of	of	IN
cord-016938-pk76snuy	153	25	oncogenesis	oncogenesis	NNP
cord-016938-pk76snuy	153	26	induction	induction	NN
cord-016938-pk76snuy	153	27	.	.	.
cord-016938-pk76snuy	154	1	To	to	TO
cord-016938-pk76snuy	154	2	produce	produce	VB
cord-016938-pk76snuy	154	3	an	an	DT
cord-016938-pk76snuy	154	4	artificial	artificial	JJ
cord-016938-pk76snuy	154	5	skin	skin	NN
cord-016938-pk76snuy	154	6	,	,	,
cord-016938-pk76snuy	154	7	autologous	autologous	JJ
cord-016938-pk76snuy	154	8	dermal	dermal	JJ
cord-016938-pk76snuy	154	9	fibroblasts	fibroblast	NNS
cord-016938-pk76snuy	154	10	of	of	IN
cord-016938-pk76snuy	154	11	rat	rat	NN
cord-016938-pk76snuy	154	12	were	be	VBD
cord-016938-pk76snuy	154	13	seeded	seed	VBN
cord-016938-pk76snuy	154	14	into	into	IN
cord-016938-pk76snuy	154	15	the	the	DT
cord-016938-pk76snuy	154	16	EDC	EDC	NNP
cord-016938-pk76snuy	154	17	crosslinked	crosslinke	VBD
cord-016938-pk76snuy	154	18	porous	porous	JJ
cord-016938-pk76snuy	154	19	collagen	collagen	NN
cord-016938-pk76snuy	154	20	-	-	HYPH
cord-016938-pk76snuy	154	21	laminin	laminin	NN
cord-016938-pk76snuy	154	22	membrane	membrane	NN
cord-016938-pk76snuy	154	23	and	and	CC
cord-016938-pk76snuy	154	24	cultured	culture	VBN
cord-016938-pk76snuy	154	25	in	in	IN
cord-016938-pk76snuy	154	26	minimum	minimum	JJ
cord-016938-pk76snuy	154	27	essential	essential	JJ
cord-016938-pk76snuy	154	28	medium	medium	NN
cord-016938-pk76snuy	154	29	(	(	-LRB-
cord-016938-pk76snuy	154	30	MEM	MEM	NNP
cord-016938-pk76snuy	154	31	)	)	-RRB-
cord-016938-pk76snuy	154	32	for	for	IN
cord-016938-pk76snuy	154	33	3	3	CD
cord-016938-pk76snuy	154	34	days	day	NNS
cord-016938-pk76snuy	154	35	to	to	TO
cord-016938-pk76snuy	154	36	provide	provide	VB
cord-016938-pk76snuy	154	37	the	the	DT
cord-016938-pk76snuy	154	38	cell	cell	NN
cord-016938-pk76snuy	154	39	-	-	HYPH
cord-016938-pk76snuy	154	40	niche	niche	NN
cord-016938-pk76snuy	154	41	adaptation	adaptation	NN
cord-016938-pk76snuy	154	42	period	period	NN
cord-016938-pk76snuy	154	43	.	.	.
cord-016938-pk76snuy	155	1	3-day	3-day	JJ
cord-016938-pk76snuy	155	2	culture	culture	NN
cord-016938-pk76snuy	155	3	is	be	VBZ
cord-016938-pk76snuy	155	4	not	not	RB
cord-016938-pk76snuy	155	5	enough	enough	JJ
cord-016938-pk76snuy	155	6	for	for	IN
cord-016938-pk76snuy	155	7	complete	complete	JJ
cord-016938-pk76snuy	155	8	proliferation	proliferation	NN
cord-016938-pk76snuy	155	9	of	of	IN
cord-016938-pk76snuy	155	10	cells	cell	NNS
cord-016938-pk76snuy	155	11	into	into	IN
cord-016938-pk76snuy	155	12	pores	pore	NNS
cord-016938-pk76snuy	155	13	,	,	,
cord-016938-pk76snuy	155	14	but	but	CC
cord-016938-pk76snuy	155	15	cells	cell	NNS
cord-016938-pk76snuy	155	16	were	be	VBD
cord-016938-pk76snuy	155	17	firmly	firmly	RB
cord-016938-pk76snuy	155	18	attached	attach	VBN
cord-016938-pk76snuy	155	19	and	and	CC
cord-016938-pk76snuy	155	20	anchored	anchor	VBN
cord-016938-pk76snuy	155	21	onto	onto	IN
cord-016938-pk76snuy	155	22	the	the	DT
cord-016938-pk76snuy	155	23	superficial	superficial	JJ
cord-016938-pk76snuy	155	24	layer	layer	NN
cord-016938-pk76snuy	155	25	of	of	IN
cord-016938-pk76snuy	155	26	the	the	DT
cord-016938-pk76snuy	155	27	porous	porous	JJ
cord-016938-pk76snuy	155	28	membrane	membrane	NN
cord-016938-pk76snuy	155	29	due	due	IN
cord-016938-pk76snuy	155	30	to	to	IN
cord-016938-pk76snuy	155	31	specific	specific	JJ
cord-016938-pk76snuy	155	32	cell	cell	NN
cord-016938-pk76snuy	155	33	adhesive	adhesive	NN
cord-016938-pk76snuy	155	34	characteristics	characteristic	NNS
cord-016938-pk76snuy	155	35	of	of	IN
cord-016938-pk76snuy	155	36	-RGD	-RGD	JJS
cord-016938-pk76snuy	155	37	-	-	HYPH
cord-016938-pk76snuy	155	38	sequences	sequence	NNS
cord-016938-pk76snuy	155	39	in	in	IN
cord-016938-pk76snuy	155	40	col-	col-	JJ
cord-016938-pk76snuy	155	41	lagen	lagen	NNP
cord-016938-pk76snuy	155	42	and	and	CC
cord-016938-pk76snuy	155	43	laminin	laminin	NNP
cord-016938-pk76snuy	155	44	.	.	.
cord-016938-pk76snuy	156	1	After	after	IN
cord-016938-pk76snuy	156	2	4	4	CD
cord-016938-pk76snuy	156	3	weeks	week	NNS
cord-016938-pk76snuy	156	4	of	of	IN
cord-016938-pk76snuy	156	5	coverage	coverage	NN
cord-016938-pk76snuy	156	6	onto	onto	IN
cord-016938-pk76snuy	156	7	a	a	DT
cord-016938-pk76snuy	156	8	grade	grade	NN
cord-016938-pk76snuy	156	9	3	3	CD
cord-016938-pk76snuy	156	10	skin	skin	NN
cord-016938-pk76snuy	156	11	wound	wound	NN
cord-016938-pk76snuy	156	12	,	,	,
cord-016938-pk76snuy	156	13	dermis	dermis	NN
cord-016938-pk76snuy	156	14	was	be	VBD
cord-016938-pk76snuy	156	15	completely	completely	RB
cord-016938-pk76snuy	156	16	replaced	replace	VBN
cord-016938-pk76snuy	156	17	,	,	,
cord-016938-pk76snuy	156	18	and	and	CC
cord-016938-pk76snuy	156	19	basement	basement	NN
cord-016938-pk76snuy	156	20	membrane	membrane	NN
cord-016938-pk76snuy	156	21	lined	line	VBN
cord-016938-pk76snuy	156	22	beneath	beneath	IN
cord-016938-pk76snuy	156	23	the	the	DT
cord-016938-pk76snuy	156	24	dense	dense	JJ
cord-016938-pk76snuy	156	25	layer	layer	NN
cord-016938-pk76snuy	156	26	as	as	IN
cord-016938-pk76snuy	156	27	the	the	DT
cord-016938-pk76snuy	156	28	seeded	seeded	JJ
cord-016938-pk76snuy	156	29	dermal	dermal	JJ
cord-016938-pk76snuy	156	30	fibroblasts	fibroblast	NNS
cord-016938-pk76snuy	156	31	were	be	VBD
cord-016938-pk76snuy	156	32	cultured	culture	VBN
cord-016938-pk76snuy	156	33	in	in	IN
cord-016938-pk76snuy	156	34	situ	situ	NN
cord-016938-pk76snuy	156	35	.	.	.
cord-016938-pk76snuy	157	1	Epithelial	epithelial	JJ
cord-016938-pk76snuy	157	2	regeneration	regeneration	NN
cord-016938-pk76snuy	157	3	upon	upon	IN
cord-016938-pk76snuy	157	4	the	the	DT
cord-016938-pk76snuy	157	5	dense	dense	JJ
cord-016938-pk76snuy	157	6	layer	layer	NN
cord-016938-pk76snuy	157	7	surface	surface	NN
cord-016938-pk76snuy	157	8	was	be	VBD
cord-016938-pk76snuy	157	9	poor	poor	JJ
cord-016938-pk76snuy	157	10	and	and	CC
cord-016938-pk76snuy	157	11	partially	partially	RB
cord-016938-pk76snuy	157	12	occupied	occupy	VBN
cord-016938-pk76snuy	157	13	by	by	IN
cord-016938-pk76snuy	157	14	the	the	DT
cord-016938-pk76snuy	157	15	keratinocytes	keratinocyte	NNS
cord-016938-pk76snuy	157	16	,	,	,
cord-016938-pk76snuy	157	17	but	but	CC
cord-016938-pk76snuy	157	18	full	full	JJ
cord-016938-pk76snuy	157	19	coverage	coverage	NN
cord-016938-pk76snuy	157	20	by	by	IN
cord-016938-pk76snuy	157	21	epithelium	epithelium	NN
cord-016938-pk76snuy	157	22	was	be	VBD
cord-016938-pk76snuy	157	23	observed	observe	VBN
cord-016938-pk76snuy	157	24	after	after	IN
cord-016938-pk76snuy	157	25	6	6	CD
cord-016938-pk76snuy	157	26	weeks	week	NNS
cord-016938-pk76snuy	157	27	.	.	.
cord-016938-pk76snuy	158	1	This	this	DT
cord-016938-pk76snuy	158	2	phenomenon	phenomenon	NN
cord-016938-pk76snuy	158	3	can	can	MD
cord-016938-pk76snuy	158	4	be	be	VB
cord-016938-pk76snuy	158	5	understood	understand	VBN
cord-016938-pk76snuy	158	6	as	as	IN
cord-016938-pk76snuy	158	7	the	the	DT
cord-016938-pk76snuy	158	8	porous	porous	JJ
cord-016938-pk76snuy	158	9	collagen	collagen	NN
cord-016938-pk76snuy	158	10	based	base	VBN
cord-016938-pk76snuy	158	11	membrane	membrane	NN
cord-016938-pk76snuy	158	12	can	can	MD
cord-016938-pk76snuy	158	13	play	play	VB
cord-016938-pk76snuy	158	14	as	as	IN
cord-016938-pk76snuy	158	15	a	a	DT
cord-016938-pk76snuy	158	16	vehicle	vehicle	NN
cord-016938-pk76snuy	158	17	for	for	IN
cord-016938-pk76snuy	158	18	dermal	dermal	JJ
cord-016938-pk76snuy	158	19	autologous	autologous	JJ
cord-016938-pk76snuy	158	20	cell	cell	NN
cord-016938-pk76snuy	158	21	delivery	delivery	NN
cord-016938-pk76snuy	158	22	,	,	,
cord-016938-pk76snuy	158	23	and	and	CC
cord-016938-pk76snuy	158	24	the	the	DT
cord-016938-pk76snuy	158	25	reconstructed	reconstruct	VBN
cord-016938-pk76snuy	158	26	basement	basement	NN
cord-016938-pk76snuy	158	27	membrane	membrane	NN
cord-016938-pk76snuy	158	28	,	,	,
cord-016938-pk76snuy	158	29	which	which	WDT
cord-016938-pk76snuy	158	30	is	be	VBZ
cord-016938-pk76snuy	158	31	a	a	DT
cord-016938-pk76snuy	158	32	keratinocyte	keratinocyte	NN
cord-016938-pk76snuy	158	33	supplying	supply	VBG
cord-016938-pk76snuy	158	34	bed	bed	NN
cord-016938-pk76snuy	158	35	in	in	IN
cord-016938-pk76snuy	158	36	nature	nature	NN
cord-016938-pk76snuy	158	37	,	,	,
cord-016938-pk76snuy	158	38	has	have	VBZ
cord-016938-pk76snuy	158	39	driven	drive	VBN
cord-016938-pk76snuy	158	40	epithelial	epithelial	JJ
cord-016938-pk76snuy	158	41	conduction	conduction	NN
cord-016938-pk76snuy	158	42	.	.	.
cord-016938-pk76snuy	159	1	Later	later	RB
cord-016938-pk76snuy	159	2	,	,	,
cord-016938-pk76snuy	159	3	a	a	DT
cord-016938-pk76snuy	159	4	collagen	collagen	NN
cord-016938-pk76snuy	159	5	-	-	HYPH
cord-016938-pk76snuy	159	6	elastin	elastin	NN
cord-016938-pk76snuy	159	7	nanofiber	nanofiber	NN
cord-016938-pk76snuy	159	8	was	be	VBD
cord-016938-pk76snuy	159	9	fabricated	fabricate	VBN
cord-016938-pk76snuy	159	10	as	as	IN
cord-016938-pk76snuy	159	11	previously	previously	RB
cord-016938-pk76snuy	159	12	described	describe	VBN
cord-016938-pk76snuy	159	13	,	,	,
cord-016938-pk76snuy	159	14	and	and	CC
cord-016938-pk76snuy	159	15	the	the	DT
cord-016938-pk76snuy	159	16	extruded	extruded	JJ
cord-016938-pk76snuy	159	17	fibers	fiber	NNS
cord-016938-pk76snuy	159	18	were	be	VBD
cord-016938-pk76snuy	159	19	brought	bring	VBN
cord-016938-pk76snuy	159	20	onto	onto	IN
cord-016938-pk76snuy	159	21	collagen	collagen	NN
cord-016938-pk76snuy	159	22	gel	gel	NN
cord-016938-pk76snuy	159	23	and	and	CC
cord-016938-pk76snuy	159	24	crosslinked	crosslinke	VBN
cord-016938-pk76snuy	159	25	by	by	IN
cord-016938-pk76snuy	159	26	EDC	EDC	NNP
cord-016938-pk76snuy	159	27	.	.	.
cord-016938-pk76snuy	160	1	Using	use	VBG
cord-016938-pk76snuy	160	2	nanofiber	nanofiber	NN
cord-016938-pk76snuy	160	3	made	make	VBD
cord-016938-pk76snuy	160	4	it	-PRON-	PRP
cord-016938-pk76snuy	160	5	possible	possible	JJ
cord-016938-pk76snuy	160	6	to	to	TO
cord-016938-pk76snuy	160	7	produce	produce	VB
cord-016938-pk76snuy	160	8	a	a	DT
cord-016938-pk76snuy	160	9	lattice	lattice	NN
cord-016938-pk76snuy	160	10	controlled	control	VBN
cord-016938-pk76snuy	160	11	matrix	matrix	NN
cord-016938-pk76snuy	160	12	,	,	,
cord-016938-pk76snuy	160	13	and	and	CC
cord-016938-pk76snuy	160	14	uniformly	uniformly	RB
cord-016938-pk76snuy	160	15	aligned	align	VBN
cord-016938-pk76snuy	160	16	lattices	lattice	NNS
cord-016938-pk76snuy	160	17	conducted	conduct	VBD
cord-016938-pk76snuy	160	18	cells	cell	NNS
cord-016938-pk76snuy	160	19	to	to	TO
cord-016938-pk76snuy	160	20	proliferate	proliferate	VB
cord-016938-pk76snuy	160	21	into	into	IN
cord-016938-pk76snuy	160	22	the	the	DT
cord-016938-pk76snuy	160	23	designed	design	VBN
cord-016938-pk76snuy	160	24	lattice	lattice	NN
cord-016938-pk76snuy	160	25	pattern	pattern	NN
cord-016938-pk76snuy	160	26	[	[	-LRB-
cord-016938-pk76snuy	160	27	11	11	CD
cord-016938-pk76snuy	160	28	]	]	-RRB-
cord-016938-pk76snuy	160	29	[	[	-LRB-
cord-016938-pk76snuy	160	30	12	12	CD
cord-016938-pk76snuy	160	31	]	]	-RRB-
cord-016938-pk76snuy	160	32	[	[	-LRB-
cord-016938-pk76snuy	160	33	13	13	CD
cord-016938-pk76snuy	160	34	]	]	-RRB-
cord-016938-pk76snuy	160	35	[	[	-LRB-
cord-016938-pk76snuy	160	36	14	14	CD
cord-016938-pk76snuy	160	37	]	]	-RRB-
cord-016938-pk76snuy	160	38	[	[	-LRB-
cord-016938-pk76snuy	160	39	15	15	CD
cord-016938-pk76snuy	160	40	]	]	-RRB-
cord-016938-pk76snuy	160	41	[	[	-LRB-
cord-016938-pk76snuy	160	42	16	16	CD
cord-016938-pk76snuy	160	43	]	]	-RRB-
cord-016938-pk76snuy	160	44	[	[	-LRB-
cord-016938-pk76snuy	160	45	17	17	CD
cord-016938-pk76snuy	160	46	]	]	-RRB-
cord-016938-pk76snuy	160	47	(	(	-LRB-
cord-016938-pk76snuy	160	48	Figs	fig	NNS
cord-016938-pk76snuy	160	49	.	.	.
cord-016938-pk76snuy	161	1	8.9	8.9	CD
cord-016938-pk76snuy	161	2	-	-	HYPH
cord-016938-pk76snuy	161	3	8.16	8.16	CD
cord-016938-pk76snuy	161	4	)	)	-RRB-
cord-016938-pk76snuy	161	5	.	.	.
cord-016938-pk76snuy	161	6	 	 	_SP
cord-016938-pk76snuy	162	1	Collagen	collagen	NN
cord-016938-pk76snuy	162	2	gel	gel	NN
cord-016938-pk76snuy	162	3	hybridized	hybridize	VBN
cord-016938-pk76snuy	162	4	with	with	IN
cord-016938-pk76snuy	162	5	calcium	calcium	NN
cord-016938-pk76snuy	162	6	phosphate	phosphate	NN
cord-016938-pk76snuy	162	7	is	be	VBZ
cord-016938-pk76snuy	162	8	applicable	applicable	JJ
cord-016938-pk76snuy	162	9	as	as	IN
cord-016938-pk76snuy	162	10	a	a	DT
cord-016938-pk76snuy	162	11	bone	bone	NN
cord-016938-pk76snuy	162	12	conductive	conductive	JJ
cord-016938-pk76snuy	162	13	substitute	substitute	NN
cord-016938-pk76snuy	162	14	.	.	.
cord-016938-pk76snuy	163	1	Apatite	apatite	NN
cord-016938-pk76snuy	163	2	(	(	-LRB-
cord-016938-pk76snuy	164	1	Ca	ca	RB
cord-016938-pk76snuy	164	2	10	10	CD
cord-016938-pk76snuy	164	3	(	(	-LRB-
cord-016938-pk76snuy	164	4	PO	PO	NNP
cord-016938-pk76snuy	164	5	4	4	CD
cord-016938-pk76snuy	164	6	)	)	-RRB-
cord-016938-pk76snuy	164	7	+	+	CC
cord-016938-pk76snuy	164	8	+	+	SYM
cord-016938-pk76snuy	164	9	6	6	CD
cord-016938-pk76snuy	164	10	)	)	-RRB-
cord-016938-pk76snuy	164	11	,	,	,
cord-016938-pk76snuy	164	12	a	a	DT
cord-016938-pk76snuy	164	13	typical	typical	JJ
cord-016938-pk76snuy	164	14	inorganic	inorganic	JJ
cord-016938-pk76snuy	164	15	component	component	NN
cord-016938-pk76snuy	164	16	of	of	IN
cord-016938-pk76snuy	164	17	skeleton	skeleton	NN
cord-016938-pk76snuy	164	18	,	,	,
cord-016938-pk76snuy	164	19	was	be	VBD
cord-016938-pk76snuy	164	20	synthesized	synthesize	VBN
cord-016938-pk76snuy	164	21	and	and	CC
cord-016938-pk76snuy	164	22	heated	heat	VBN
cord-016938-pk76snuy	164	23	at	at	IN
cord-016938-pk76snuy	164	24	980	980	CD
cord-016938-pk76snuy	164	25	•	•	NN
cord-016938-pk76snuy	164	26	C	c	NN
cord-016938-pk76snuy	164	27	after	after	IN
cord-016938-pk76snuy	164	28	which	which	WDT
cord-016938-pk76snuy	164	29	apatite	apatite	NN
cord-016938-pk76snuy	164	30	crystals	crystal	NNS
cord-016938-pk76snuy	164	31	were	be	VBD
cord-016938-pk76snuy	164	32	not	not	RB
cord-016938-pk76snuy	164	33	sintered	sinter	VBN
cord-016938-pk76snuy	164	34	but	but	CC
cord-016938-pk76snuy	164	35	degradable	degradable	JJ
cord-016938-pk76snuy	164	36	by	by	IN
cord-016938-pk76snuy	164	37	hydrolysis	hydrolysis	NN
cord-016938-pk76snuy	164	38	.	.	.
cord-016938-pk76snuy	165	1	1	1	CD
cord-016938-pk76snuy	165	2	%	%	NN
cord-016938-pk76snuy	165	3	collagen	collagen	NN
cord-016938-pk76snuy	165	4	gel	gel	NN
cord-016938-pk76snuy	165	5	was	be	VBD
cord-016938-pk76snuy	165	6	mixed	mix	VBN
cord-016938-pk76snuy	165	7	with	with	IN
cord-016938-pk76snuy	165	8	the	the	DT
cord-016938-pk76snuy	165	9	apatite	apatite	NN
cord-016938-pk76snuy	165	10	in	in	IN
cord-016938-pk76snuy	165	11	12:88	12:88	CD
cord-016938-pk76snuy	165	12	w	w	NN
cord-016938-pk76snuy	165	13	/	/	SYM
cord-016938-pk76snuy	165	14	v	v	NN
cord-016938-pk76snuy	165	15	,	,	,
cord-016938-pk76snuy	165	16	and	and	CC
cord-016938-pk76snuy	165	17	the	the	DT
cord-016938-pk76snuy	165	18	mixture	mixture	NN
cord-016938-pk76snuy	165	19	was	be	VBD
cord-016938-pk76snuy	165	20	crosslinked	crosslinke	VBN
cord-016938-pk76snuy	165	21	.	.	.
cord-016938-pk76snuy	166	1	Then	then	RB
cord-016938-pk76snuy	166	2	the	the	DT
cord-016938-pk76snuy	166	3	produced	produce	VBN
cord-016938-pk76snuy	166	4	apatite	apatite	NN
cord-016938-pk76snuy	166	5	-	-	HYPH
cord-016938-pk76snuy	166	6	collagen	collagen	NN
cord-016938-pk76snuy	166	7	pellet	pellet	NN
cord-016938-pk76snuy	166	8	was	be	VBD
cord-016938-pk76snuy	166	9	implanted	implant	VBN
cord-016938-pk76snuy	166	10	into	into	IN
cord-016938-pk76snuy	166	11	rabbit	rabbit	NN
cord-016938-pk76snuy	166	12	's	's	POS
cord-016938-pk76snuy	166	13	resected	resected	JJ
cord-016938-pk76snuy	166	14	tibiae	tibia	NNS
cord-016938-pk76snuy	166	15	.	.	.
cord-016938-pk76snuy	167	1	4	4	CD
cord-016938-pk76snuy	167	2	weeks	week	NNS
cord-016938-pk76snuy	167	3	after	after	IN
cord-016938-pk76snuy	167	4	implantation	implantation	NN
cord-016938-pk76snuy	167	5	,	,	,
cord-016938-pk76snuy	167	6	the	the	DT
cord-016938-pk76snuy	167	7	resected	resected	JJ
cord-016938-pk76snuy	167	8	defect	defect	NN
cord-016938-pk76snuy	167	9	was	be	VBD
cord-016938-pk76snuy	167	10	completely	completely	RB
cord-016938-pk76snuy	167	11	regenerated	regenerate	VBN
cord-016938-pk76snuy	167	12	by	by	IN
cord-016938-pk76snuy	167	13	host	host	NN
cord-016938-pk76snuy	167	14	bone	bone	NN
cord-016938-pk76snuy	167	15	with	with	IN
cord-016938-pk76snuy	167	16	cortical	cortical	JJ
cord-016938-pk76snuy	167	17	bone	bone	NN
cord-016938-pk76snuy	167	18	continuity	continuity	NN
cord-016938-pk76snuy	167	19	and	and	CC
cord-016938-pk76snuy	167	20	cancellous	cancellous	JJ
cord-016938-pk76snuy	167	21	bone	bone	NN
cord-016938-pk76snuy	167	22	stroma	stroma	NNP
cord-016938-pk76snuy	167	23	,	,	,
cord-016938-pk76snuy	167	24	and	and	CC
cord-016938-pk76snuy	167	25	after	after	IN
cord-016938-pk76snuy	167	26	that	that	DT
cord-016938-pk76snuy	167	27	,	,	,
cord-016938-pk76snuy	167	28	typical	typical	JJ
cord-016938-pk76snuy	167	29	bone	bone	NN
cord-016938-pk76snuy	167	30	remodeling	remodeling	NN
cord-016938-pk76snuy	167	31	process	process	NN
cord-016938-pk76snuy	167	32	followed	follow	VBD
cord-016938-pk76snuy	167	33	to	to	TO
cord-016938-pk76snuy	167	34	produce	produce	VB
cord-016938-pk76snuy	167	35	natural	natural	JJ
cord-016938-pk76snuy	167	36	bone	bone	NN
cord-016938-pk76snuy	167	37	.	.	.
cord-016938-pk76snuy	168	1	However	however	RB
cord-016938-pk76snuy	168	2	,	,	,
cord-016938-pk76snuy	168	3	mechanical	mechanical	JJ
cord-016938-pk76snuy	168	4	strength	strength	NN
cord-016938-pk76snuy	168	5	of	of	IN
cord-016938-pk76snuy	168	6	the	the	DT
cord-016938-pk76snuy	168	7	regenerated	regenerated	JJ
cord-016938-pk76snuy	168	8	area	area	NN
cord-016938-pk76snuy	168	9	was	be	VBD
cord-016938-pk76snuy	168	10	less	less	JJR
cord-016938-pk76snuy	168	11	than	than	IN
cord-016938-pk76snuy	168	12	general	general	JJ
cord-016938-pk76snuy	168	13	bone	bone	NN
cord-016938-pk76snuy	168	14	.	.	.
cord-016938-pk76snuy	169	1	Although	although	IN
cord-016938-pk76snuy	169	2	collagen	collagen	NN
cord-016938-pk76snuy	169	3	based	base	VBN
cord-016938-pk76snuy	169	4	gel	gel	NN
cord-016938-pk76snuy	169	5	is	be	VBZ
cord-016938-pk76snuy	169	6	favorable	favorable	JJ
cord-016938-pk76snuy	169	7	to	to	TO
cord-016938-pk76snuy	169	8	fabricate	fabricate	VB
cord-016938-pk76snuy	169	9	cell	cell	NN
cord-016938-pk76snuy	169	10	conductive	conductive	JJ
cord-016938-pk76snuy	169	11	substitute	substitute	NN
cord-016938-pk76snuy	169	12	,	,	,
cord-016938-pk76snuy	169	13	weak	weak	JJ
cord-016938-pk76snuy	169	14	mechanical	mechanical	JJ
cord-016938-pk76snuy	169	15	property	property	NN
cord-016938-pk76snuy	169	16	is	be	VBZ
cord-016938-pk76snuy	169	17	a	a	DT
cord-016938-pk76snuy	169	18	barrier	barrier	NN
cord-016938-pk76snuy	169	19	for	for	IN
cord-016938-pk76snuy	169	20	application	application	NN
cord-016938-pk76snuy	169	21	in	in	IN
cord-016938-pk76snuy	169	22	the	the	DT
cord-016938-pk76snuy	169	23	physiological	physiological	JJ
cord-016938-pk76snuy	169	24	stress	stress	NN
cord-016938-pk76snuy	169	25	bearing	bear	VBG
cord-016938-pk76snuy	169	26	tissues	tissue	NNS
cord-016938-pk76snuy	169	27	,	,	,
cord-016938-pk76snuy	169	28	and	and	CC
cord-016938-pk76snuy	169	29	,	,	,
cord-016938-pk76snuy	169	30	to	to	TO
cord-016938-pk76snuy	169	31	resolve	resolve	VB
cord-016938-pk76snuy	169	32	this	this	DT
cord-016938-pk76snuy	169	33	problem	problem	NN
cord-016938-pk76snuy	169	34	,	,	,
cord-016938-pk76snuy	169	35	hybridization	hybridization	NN
cord-016938-pk76snuy	169	36	of	of	IN
cord-016938-pk76snuy	169	37	collagen	collagen	NN
cord-016938-pk76snuy	169	38	with	with	IN
cord-016938-pk76snuy	169	39	polymeric	polymeric	JJ
cord-016938-pk76snuy	169	40	biomaterials	biomaterial	NNS
cord-016938-pk76snuy	169	41	has	have	VBZ
cord-016938-pk76snuy	169	42	been	be	VBN
cord-016938-pk76snuy	169	43	suggested	suggest	VBN
cord-016938-pk76snuy	169	44	.	.	.
cord-016938-pk76snuy	170	1	Introducing	introduce	VBG
cord-016938-pk76snuy	170	2	functional	functional	JJ
cord-016938-pk76snuy	170	3	groups	group	NNS
cord-016938-pk76snuy	170	4	on	on	IN
cord-016938-pk76snuy	170	5	esters	ester	NNS
cord-016938-pk76snuy	170	6	,	,	,
cord-016938-pk76snuy	170	7	such	such	JJ
cord-016938-pk76snuy	170	8	as	as	IN
cord-016938-pk76snuy	170	9	polyurethane	polyurethane	NN
cord-016938-pk76snuy	170	10	(	(	-LRB-
cord-016938-pk76snuy	170	11	PU	PU	NNP
cord-016938-pk76snuy	170	12	)	)	-RRB-
cord-016938-pk76snuy	170	13	and	and	CC
cord-016938-pk76snuy	170	14	poly	poly	JJ
cord-016938-pk76snuy	170	15	lactic	lactic	NN
cord-016938-pk76snuy	170	16	-	-	HYPH
cord-016938-pk76snuy	170	17	glycolic	glycolic	NN
cord-016938-pk76snuy	170	18	acid	acid	NN
cord-016938-pk76snuy	170	19	(	(	-LRB-
cord-016938-pk76snuy	170	20	PL	pl	NN
cord-016938-pk76snuy	170	21	-	-	HYPH
cord-016938-pk76snuy	170	22	GA	GA	NNP
cord-016938-pk76snuy	170	23	)	)	-RRB-
cord-016938-pk76snuy	170	24	,	,	,
cord-016938-pk76snuy	170	25	through	through	IN
cord-016938-pk76snuy	170	26	treatment	treatment	NN
cord-016938-pk76snuy	170	27	with	with	IN
cord-016938-pk76snuy	170	28	ozone	ozone	NN
cord-016938-pk76snuy	170	29	induces	induce	VBZ
cord-016938-pk76snuy	170	30	surface	surface	NN
cord-016938-pk76snuy	170	31	oxidization	oxidization	NN
cord-016938-pk76snuy	170	32	that	that	WDT
cord-016938-pk76snuy	170	33	produces	produce	VBZ
cord-016938-pk76snuy	170	34	carboxyl	carboxyl	NN
cord-016938-pk76snuy	170	35	groups	group	NNS
cord-016938-pk76snuy	170	36	on	on	IN
cord-016938-pk76snuy	170	37	the	the	DT
cord-016938-pk76snuy	170	38	surface	surface	NN
cord-016938-pk76snuy	170	39	which	which	WDT
cord-016938-pk76snuy	170	40	react	react	VBP
cord-016938-pk76snuy	170	41	with	with	IN
cord-016938-pk76snuy	170	42	amines	amine	NNS
cord-016938-pk76snuy	170	43	in	in	IN
cord-016938-pk76snuy	170	44	collagen	collagen	NN
cord-016938-pk76snuy	170	45	.	.	.
cord-016938-pk76snuy	171	1	As	as	IN
cord-016938-pk76snuy	171	2	the	the	DT
cord-016938-pk76snuy	171	3	apatite	apatite	NN
cord-016938-pk76snuy	171	4	-	-	HYPH
cord-016938-pk76snuy	171	5	collagen	collagen	NN
cord-016938-pk76snuy	171	6	provided	provide	VBD
cord-016938-pk76snuy	171	7	insufficient	insufficient	JJ
cord-016938-pk76snuy	171	8	strength	strength	NN
cord-016938-pk76snuy	171	9	despite	despite	IN
cord-016938-pk76snuy	171	10	promotion	promotion	NN
cord-016938-pk76snuy	171	11	of	of	IN
cord-016938-pk76snuy	171	12	a	a	DT
cord-016938-pk76snuy	171	13	favorable	favorable	JJ
cord-016938-pk76snuy	171	14	osteogenesis	osteogenesis	NN
cord-016938-pk76snuy	171	15	,	,	,
cord-016938-pk76snuy	171	16	collagen	collagen	NN
cord-016938-pk76snuy	171	17	was	be	VBD
cord-016938-pk76snuy	171	18	grafted	graft	VBN
cord-016938-pk76snuy	171	19	onto	onto	IN
cord-016938-pk76snuy	171	20	the	the	DT
cord-016938-pk76snuy	171	21	biodegradable	biodegradable	JJ
cord-016938-pk76snuy	171	22	PLA	PLA	NNP
cord-016938-pk76snuy	171	23	membrane	membrane	NN
cord-016938-pk76snuy	171	24	to	to	TO
cord-016938-pk76snuy	171	25	reinforce	reinforce	VB
cord-016938-pk76snuy	171	26	the	the	DT
cord-016938-pk76snuy	171	27	strength	strength	NN
cord-016938-pk76snuy	171	28	.	.	.
cord-016938-pk76snuy	172	1	PLA	PLA	NNP
cord-016938-pk76snuy	172	2	of	of	IN
cord-016938-pk76snuy	172	3	M.W.	M.W.	NNP
cord-016938-pk76snuy	172	4	50,000	50,000	CD
cord-016938-pk76snuy	172	5	was	be	VBD
cord-016938-pk76snuy	172	6	resolved	resolve	VBN
cord-016938-pk76snuy	172	7	by	by	IN
cord-016938-pk76snuy	172	8	99	99	CD
cord-016938-pk76snuy	172	9	%	%	NN
cord-016938-pk76snuy	172	10	chloroform	chloroform	NN
cord-016938-pk76snuy	172	11	solution	solution	NN
cord-016938-pk76snuy	172	12	to	to	TO
cord-016938-pk76snuy	172	13	produce	produce	VB
cord-016938-pk76snuy	172	14	9	9	CD
cord-016938-pk76snuy	172	15	%	%	NN
cord-016938-pk76snuy	172	16	(	(	-LRB-
cord-016938-pk76snuy	172	17	W	w	NN
cord-016938-pk76snuy	172	18	/	/	SYM
cord-016938-pk76snuy	172	19	V	v	NN
cord-016938-pk76snuy	172	20	)	)	-RRB-
cord-016938-pk76snuy	172	21	PLA	pla	NN
cord-016938-pk76snuy	172	22	solution	solution	NN
cord-016938-pk76snuy	172	23	,	,	,
cord-016938-pk76snuy	172	24	and	and	CC
cord-016938-pk76snuy	172	25	NaCl	nacl	NN
cord-016938-pk76snuy	172	26	crystals	crystal	NNS
cord-016938-pk76snuy	172	27	(	(	-LRB-
cord-016938-pk76snuy	172	28	425	425	CD
cord-016938-pk76snuy	172	29	-500	-500	NN
cord-016938-pk76snuy	172	30	μm	μm	NN
cord-016938-pk76snuy	172	31	)	)	-RRB-
cord-016938-pk76snuy	172	32	were	be	VBD
cord-016938-pk76snuy	172	33	mixed	mix	VBN
cord-016938-pk76snuy	172	34	to	to	IN
cord-016938-pk76snuy	172	35	the	the	DT
cord-016938-pk76snuy	172	36	PLA	PLA	NNP
cord-016938-pk76snuy	172	37	solution	solution	NN
cord-016938-pk76snuy	172	38	with	with	IN
cord-016938-pk76snuy	172	39	adjusting	adjust	VBG
cord-016938-pk76snuy	172	40	NaCl	nacl	NN
cord-016938-pk76snuy	172	41	:	:	:
cord-016938-pk76snuy	173	1	PLA	PLA	NNP
cord-016938-pk76snuy	173	2	ratio	ratio	NN
cord-016938-pk76snuy	173	3	to	to	IN
cord-016938-pk76snuy	173	4	9:1	9:1	CD
cord-016938-pk76snuy	174	1	(	(	-LRB-
cord-016938-pk76snuy	174	2	w	w	NNP
cord-016938-pk76snuy	174	3	/	/	SYM
cord-016938-pk76snuy	174	4	w	w	NN
cord-016938-pk76snuy	174	5	)	)	-RRB-
cord-016938-pk76snuy	174	6	.	.	.
cord-016938-pk76snuy	175	1	The	the	DT
cord-016938-pk76snuy	175	2	prepared	prepared	JJ
cord-016938-pk76snuy	175	3	solution	solution	NN
cord-016938-pk76snuy	175	4	was	be	VBD
cord-016938-pk76snuy	175	5	cast	cast	VBN
cord-016938-pk76snuy	175	6	into	into	IN
cord-016938-pk76snuy	175	7	an	an	DT
cord-016938-pk76snuy	175	8	appropriate	appropriate	JJ
cord-016938-pk76snuy	175	9	shape	shape	NN
cord-016938-pk76snuy	175	10	,	,	,
cord-016938-pk76snuy	175	11	and	and	CC
cord-016938-pk76snuy	175	12	the	the	DT
cord-016938-pk76snuy	175	13	solvent	solvent	NN
cord-016938-pk76snuy	175	14	was	be	VBD
cord-016938-pk76snuy	175	15	allowed	allow	VBN
cord-016938-pk76snuy	175	16	to	to	TO
cord-016938-pk76snuy	175	17	evaporate	evaporate	VB
cord-016938-pk76snuy	175	18	over	over	IN
cord-016938-pk76snuy	175	19	24	24	CD
cord-016938-pk76snuy	175	20	hrs	hrs	NN
cord-016938-pk76snuy	175	21	to	to	TO
cord-016938-pk76snuy	175	22	produce	produce	VB
cord-016938-pk76snuy	175	23	a	a	DT
cord-016938-pk76snuy	175	24	porous	porous	JJ
cord-016938-pk76snuy	175	25	membrane	membrane	NN
cord-016938-pk76snuy	175	26	after	after	IN
cord-016938-pk76snuy	175	27	leaching	leach	VBG
cord-016938-pk76snuy	175	28	out	out	RP
cord-016938-pk76snuy	175	29	the	the	DT
cord-016938-pk76snuy	175	30	NaCl	nacl	NN
cord-016938-pk76snuy	175	31	particles	particle	NNS
cord-016938-pk76snuy	175	32	with	with	IN
cord-016938-pk76snuy	175	33	distilled	distilled	JJ
cord-016938-pk76snuy	175	34	water	water	NN
cord-016938-pk76snuy	175	35	.	.	.
cord-016938-pk76snuy	176	1	To	to	TO
cord-016938-pk76snuy	176	2	induce	induce	VB
cord-016938-pk76snuy	176	3	molecular	molecular	JJ
cord-016938-pk76snuy	176	4	bindings	binding	NNS
cord-016938-pk76snuy	176	5	between	between	IN
cord-016938-pk76snuy	176	6	the	the	DT
cord-016938-pk76snuy	176	7	collagen	collagen	NN
cord-016938-pk76snuy	176	8	within	within	IN
cord-016938-pk76snuy	176	9	apatite	apatite	NN
cord-016938-pk76snuy	176	10	-	-	HYPH
cord-016938-pk76snuy	176	11	collagen	collagen	NN
cord-016938-pk76snuy	176	12	composite	composite	NN
cord-016938-pk76snuy	176	13	and	and	CC
cord-016938-pk76snuy	176	14	the	the	DT
cord-016938-pk76snuy	176	15	PLA	PLA	NNP
cord-016938-pk76snuy	176	16	membrane	membrane	NN
cord-016938-pk76snuy	176	17	surface	surface	NN
cord-016938-pk76snuy	176	18	,	,	,
cord-016938-pk76snuy	176	19	PLA	PLA	NNP
cord-016938-pk76snuy	176	20	membrane	membrane	NN
cord-016938-pk76snuy	176	21	was	be	VBD
cord-016938-pk76snuy	176	22	oxidized	oxidize	VBN
cord-016938-pk76snuy	176	23	by	by	IN
cord-016938-pk76snuy	176	24	ozone	ozone	NN
cord-016938-pk76snuy	176	25	to	to	TO
cord-016938-pk76snuy	176	26	produce	produce	VB
cord-016938-pk76snuy	176	27	reactive	reactive	JJ
cord-016938-pk76snuy	176	28	carboxyl	carboxyl	NN
cord-016938-pk76snuy	176	29	and	and	CC
cord-016938-pk76snuy	176	30	hydroperoxide	hydroperoxide	NN
cord-016938-pk76snuy	176	31	groups	group	NNS
cord-016938-pk76snuy	176	32	on	on	IN
cord-016938-pk76snuy	176	33	the	the	DT
cord-016938-pk76snuy	176	34	PLA	PLA	NNP
cord-016938-pk76snuy	176	35	surface	surface	NN
cord-016938-pk76snuy	176	36	.	.	.
cord-016938-pk76snuy	177	1	After	after	IN
cord-016938-pk76snuy	177	2	the	the	DT
cord-016938-pk76snuy	177	3	ozone	ozone	NN
cord-016938-pk76snuy	177	4	treatment	treatment	NN
cord-016938-pk76snuy	177	5	at	at	IN
cord-016938-pk76snuy	177	6	60	60	CD
cord-016938-pk76snuy	177	7	V	v	NN
cord-016938-pk76snuy	177	8	for	for	IN
cord-016938-pk76snuy	177	9	60	60	CD
cord-016938-pk76snuy	177	10	min	min	NN
cord-016938-pk76snuy	177	11	,	,	,
cord-016938-pk76snuy	177	12	apatite	apatite	NN
cord-016938-pk76snuy	177	13	-	-	HYPH
cord-016938-pk76snuy	177	14	collagen	collagen	NN
cord-016938-pk76snuy	177	15	was	be	VBD
cord-016938-pk76snuy	177	16	delivered	deliver	VBN
cord-016938-pk76snuy	177	17	onto	onto	IN
cord-016938-pk76snuy	177	18	the	the	DT
cord-016938-pk76snuy	177	19	ozone	ozone	NN
cord-016938-pk76snuy	177	20	treated	treat	VBN
cord-016938-pk76snuy	177	21	PLA	PLA	NNP
cord-016938-pk76snuy	177	22	membrane	membrane	NN
cord-016938-pk76snuy	177	23	to	to	TO
cord-016938-pk76snuy	177	24	produce	produce	VB
cord-016938-pk76snuy	177	25	an	an	DT
cord-016938-pk76snuy	177	26	apatite	apatite	NN
cord-016938-pk76snuy	177	27	-	-	HYPH
cord-016938-pk76snuy	177	28	collagen	collagen	NN
cord-016938-pk76snuy	177	29	grafted	graft	VBN
cord-016938-pk76snuy	177	30	PLA	PLA	NNP
cord-016938-pk76snuy	177	31	membrane	membrane	NN
cord-016938-pk76snuy	177	32	.	.	.
cord-016938-pk76snuy	178	1	The	the	DT
cord-016938-pk76snuy	178	2	grafted	grafted	JJ
cord-016938-pk76snuy	178	3	membrane	membrane	NN
cord-016938-pk76snuy	178	4	was	be	VBD
cord-016938-pk76snuy	178	5	pressed	press	VBN
cord-016938-pk76snuy	178	6	(	(	-LRB-
cord-016938-pk76snuy	178	7	1	1	CD
cord-016938-pk76snuy	178	8	bar	bar	NN
cord-016938-pk76snuy	178	9	at	at	IN
cord-016938-pk76snuy	178	10	37	37	CD
cord-016938-pk76snuy	178	11	•	•	NN
cord-016938-pk76snuy	178	12	C	c	NN
cord-016938-pk76snuy	178	13	)	)	-RRB-
cord-016938-pk76snuy	178	14	from	from	IN
cord-016938-pk76snuy	178	15	vertical	vertical	JJ
cord-016938-pk76snuy	178	16	direction	direction	NN
cord-016938-pk76snuy	178	17	,	,	,
cord-016938-pk76snuy	178	18	and	and	CC
cord-016938-pk76snuy	178	19	then	then	RB
cord-016938-pk76snuy	178	20	EDC	EDC	NNP
cord-016938-pk76snuy	178	21	collagen	collagen	NNP
cord-016938-pk76snuy	178	22	cross	cross	NN
cord-016938-pk76snuy	178	23	-	-	NN
cord-016938-pk76snuy	178	24	linking	linking	NN
cord-016938-pk76snuy	178	25	was	be	VBD
cord-016938-pk76snuy	178	26	performed	perform	VBN
cord-016938-pk76snuy	178	27	to	to	TO
cord-016938-pk76snuy	178	28	integrate	integrate	VB
cord-016938-pk76snuy	178	29	the	the	DT
cord-016938-pk76snuy	178	30	mixed	mixed	JJ
cord-016938-pk76snuy	178	31	atelocollagen	atelocollagen	NN
cord-016938-pk76snuy	178	32	fibers	fiber	NNS
cord-016938-pk76snuy	178	33	in	in	IN
cord-016938-pk76snuy	178	34	the	the	DT
cord-016938-pk76snuy	178	35	grafted	graft	VBN
cord-016938-pk76snuy	178	36	material	material	NN
cord-016938-pk76snuy	178	37	.	.	.
cord-016938-pk76snuy	179	1	The	the	DT
cord-016938-pk76snuy	179	2	final	final	JJ
cord-016938-pk76snuy	179	3	product	product	NN
cord-016938-pk76snuy	179	4	was	be	VBD
cord-016938-pk76snuy	179	5	im-	im-	JJ
cord-016938-pk76snuy	179	6	 	 	_SP
cord-016938-pk76snuy	180	1	Collagen	collagen	NN
cord-016938-pk76snuy	180	2	grafted	graft	VBD
cord-016938-pk76snuy	180	3	synthetic	synthetic	JJ
cord-016938-pk76snuy	180	4	polymer	polymer	NN
cord-016938-pk76snuy	180	5	is	be	VBZ
cord-016938-pk76snuy	180	6	applicable	applicable	JJ
cord-016938-pk76snuy	180	7	to	to	IN
cord-016938-pk76snuy	180	8	soft	soft	JJ
cord-016938-pk76snuy	180	9	tissue	tissue	NN
cord-016938-pk76snuy	180	10	replacement	replacement	NN
cord-016938-pk76snuy	180	11	as	as	RB
cord-016938-pk76snuy	180	12	well	well	RB
cord-016938-pk76snuy	180	13	.	.	.
cord-016938-pk76snuy	181	1	Except	except	IN
cord-016938-pk76snuy	181	2	the	the	DT
cord-016938-pk76snuy	181	3	air	air	NN
cord-016938-pk76snuy	181	4	passages	passage	NNS
cord-016938-pk76snuy	181	5	such	such	JJ
cord-016938-pk76snuy	181	6	as	as	IN
cord-016938-pk76snuy	181	7	trachea	trachea	NN
cord-016938-pk76snuy	181	8	and	and	CC
cord-016938-pk76snuy	181	9	bronchus	bronchus	NN
cord-016938-pk76snuy	181	10	which	which	WDT
cord-016938-pk76snuy	181	11	require	require	VBP
cord-016938-pk76snuy	181	12	almost	almost	RB
cord-016938-pk76snuy	181	13	no	no	DT
cord-016938-pk76snuy	181	14	repeating	repeat	VBG
cord-016938-pk76snuy	181	15	dilatation	dilatation	NN
cord-016938-pk76snuy	181	16	-	-	HYPH
cord-016938-pk76snuy	181	17	shrinkage	shrinkage	NN
cord-016938-pk76snuy	181	18	action	action	NN
cord-016938-pk76snuy	181	19	of	of	IN
cord-016938-pk76snuy	181	20	compliance	compliance	NN
cord-016938-pk76snuy	181	21	,	,	,
cord-016938-pk76snuy	181	22	most	most	JJS
cord-016938-pk76snuy	181	23	of	of	IN
cord-016938-pk76snuy	181	24	the	the	DT
cord-016938-pk76snuy	181	25	tubular	tubular	JJ
cord-016938-pk76snuy	181	26	-	-	HYPH
cord-016938-pk76snuy	181	27	shaped	shaped	JJ
cord-016938-pk76snuy	181	28	tissue	tissue	NN
cord-016938-pk76snuy	181	29	requires	require	VBZ
cord-016938-pk76snuy	181	30	various	various	JJ
cord-016938-pk76snuy	181	31	level	level	NN
cord-016938-pk76snuy	181	32	of	of	IN
cord-016938-pk76snuy	181	33	compliance	compliance	NN
cord-016938-pk76snuy	181	34	against	against	IN
cord-016938-pk76snuy	181	35	the	the	DT
cord-016938-pk76snuy	181	36	mass	mass	NN
cord-016938-pk76snuy	181	37	passing	pass	VBG
cord-016938-pk76snuy	181	38	through	through	IN
cord-016938-pk76snuy	181	39	lumen	lumen	NN
cord-016938-pk76snuy	181	40	,	,	,
cord-016938-pk76snuy	181	41	as	as	IN
cord-016938-pk76snuy	181	42	arteries	artery	NNS
cord-016938-pk76snuy	181	43	to	to	IN
cord-016938-pk76snuy	181	44	pulsating	pulsate	VBG
cord-016938-pk76snuy	181	45	blood	blood	NN
cord-016938-pk76snuy	181	46	flow	flow	NN
cord-016938-pk76snuy	181	47	and	and	CC
cord-016938-pk76snuy	181	48	esophagus	esophagus	NN
cord-016938-pk76snuy	181	49	to	to	IN
cord-016938-pk76snuy	181	50	swallowing	swallow	VBG
cord-016938-pk76snuy	181	51	dietary	dietary	JJ
cord-016938-pk76snuy	181	52	mass	mass	NN
cord-016938-pk76snuy	181	53	.	.	.
cord-016938-pk76snuy	182	1	In	in	IN
cord-016938-pk76snuy	182	2	general	general	JJ
cord-016938-pk76snuy	182	3	,	,	,
cord-016938-pk76snuy	182	4	tubular	tubular	JJ
cord-016938-pk76snuy	182	5	walls	wall	NNS
cord-016938-pk76snuy	182	6	of	of	IN
cord-016938-pk76snuy	182	7	those	those	DT
cord-016938-pk76snuy	182	8	tissues	tissue	NNS
cord-016938-pk76snuy	182	9	consist	consist	VBP
cord-016938-pk76snuy	182	10	of	of	IN
cord-016938-pk76snuy	182	11	multiple	multiple	JJ
cord-016938-pk76snuy	182	12	-	-	HYPH
cord-016938-pk76snuy	182	13	layered	layered	JJ
cord-016938-pk76snuy	182	14	smooth	smooth	JJ
cord-016938-pk76snuy	182	15	muscle	muscle	NN
cord-016938-pk76snuy	182	16	cells	cell	NNS
cord-016938-pk76snuy	182	17	to	to	TO
cord-016938-pk76snuy	182	18	resist	resist	VB
cord-016938-pk76snuy	182	19	against	against	IN
cord-016938-pk76snuy	182	20	pressure	pressure	NN
cord-016938-pk76snuy	182	21	at	at	IN
cord-016938-pk76snuy	182	22	luminal	luminal	JJ
cord-016938-pk76snuy	182	23	wall	wall	NN
cord-016938-pk76snuy	182	24	exerted	exert	VBN
cord-016938-pk76snuy	182	25	by	by	IN
cord-016938-pk76snuy	182	26	transporting	transport	VBG
cord-016938-pk76snuy	182	27	mass	mass	NN
cord-016938-pk76snuy	182	28	,	,	,
cord-016938-pk76snuy	182	29	and	and	CC
cord-016938-pk76snuy	182	30	appropriate	appropriate	JJ
cord-016938-pk76snuy	182	31	flexibility	flexibility	NN
cord-016938-pk76snuy	182	32	is	be	VBZ
cord-016938-pk76snuy	182	33	required	require	VBN
cord-016938-pk76snuy	182	34	.	.	.
cord-016938-pk76snuy	183	1	To	to	TO
cord-016938-pk76snuy	183	2	replace	replace	VB
cord-016938-pk76snuy	183	3	esophagus	esophagus	NN
cord-016938-pk76snuy	183	4	,	,	,
cord-016938-pk76snuy	183	5	polyurethane	polyurethane	NN
cord-016938-pk76snuy	183	6	,	,	,
cord-016938-pk76snuy	183	7	a	a	DT
cord-016938-pk76snuy	183	8	bioinert	bioinert	JJ
cord-016938-pk76snuy	183	9	biomaterial	biomaterial	NN
cord-016938-pk76snuy	183	10	with	with	IN
cord-016938-pk76snuy	183	11	mechanical	mechanical	JJ
cord-016938-pk76snuy	183	12	advantage	advantage	NN
cord-016938-pk76snuy	183	13	of	of	IN
cord-016938-pk76snuy	183	14	high	high	JJ
cord-016938-pk76snuy	183	15	durability	durability	NN
cord-016938-pk76snuy	183	16	against	against	IN
cord-016938-pk76snuy	183	17	continuous	continuous	JJ
cord-016938-pk76snuy	183	18	bending	bending	NN
cord-016938-pk76snuy	183	19	stresses	stress	NNS
cord-016938-pk76snuy	183	20	,	,	,
cord-016938-pk76snuy	183	21	was	be	VBD
cord-016938-pk76snuy	183	22	employed	employ	VBN
cord-016938-pk76snuy	183	23	.	.	.
cord-016938-pk76snuy	184	1	An	an	DT
cord-016938-pk76snuy	184	2	approach	approach	NN
cord-016938-pk76snuy	184	3	is	be	VBZ
cord-016938-pk76snuy	184	4	presented	present	VBN
cord-016938-pk76snuy	184	5	for	for	IN
cord-016938-pk76snuy	184	6	graft	graft	NN
cord-016938-pk76snuy	184	7	copolymerization	copolymerization	NN
cord-016938-pk76snuy	184	8	of	of	IN
cord-016938-pk76snuy	184	9	type	type	NN
cord-016938-pk76snuy	185	1	I	-PRON-	PRP
cord-016938-pk76snuy	185	2	atelocollagen	atelocollagen	VBP
cord-016938-pk76snuy	185	3	onto	onto	IN
cord-016938-pk76snuy	185	4	surface	surface	NN
cord-016938-pk76snuy	185	5	of	of	IN
cord-016938-pk76snuy	185	6	polyurethane	polyurethane	NN
cord-016938-pk76snuy	185	7	(	(	-LRB-
cord-016938-pk76snuy	185	8	PU	PU	NNP
cord-016938-pk76snuy	185	9	)	)	-RRB-
cord-016938-pk76snuy	185	10	treated	treat	VBN
cord-016938-pk76snuy	185	11	with	with	IN
cord-016938-pk76snuy	185	12	ozone	ozone	NN
cord-016938-pk76snuy	185	13	.	.	.
cord-016938-pk76snuy	186	1	Through	through	IN
cord-016938-pk76snuy	186	2	surface	surface	NN
cord-016938-pk76snuy	186	3	oxidization	oxidization	NN
cord-016938-pk76snuy	186	4	by	by	IN
cord-016938-pk76snuy	186	5	ozone	ozone	NN
cord-016938-pk76snuy	186	6	to	to	TO
cord-016938-pk76snuy	186	7	modify	modify	VB
cord-016938-pk76snuy	186	8	the	the	DT
cord-016938-pk76snuy	186	9	PU	PU	NNP
cord-016938-pk76snuy	186	10	surface	surface	NN
cord-016938-pk76snuy	186	11	,	,	,
cord-016938-pk76snuy	186	12	peroxide	peroxide	NN
cord-016938-pk76snuy	186	13	groups	group	NNS
cord-016938-pk76snuy	186	14	are	be	VBP
cord-016938-pk76snuy	186	15	easily	easily	RB
cord-016938-pk76snuy	186	16	generated	generate	VBN
cord-016938-pk76snuy	186	17	.	.	.
cord-016938-pk76snuy	187	1	Those	those	DT
cord-016938-pk76snuy	187	2	peroxides	peroxide	NNS
cord-016938-pk76snuy	187	3	are	be	VBP
cord-016938-pk76snuy	187	4	broken	break	VBN
cord-016938-pk76snuy	187	5	down	down	RP
cord-016938-pk76snuy	187	6	by	by	IN
cord-016938-pk76snuy	187	7	redox	redox	NN
cord-016938-pk76snuy	187	8	-	-	HYPH
cord-016938-pk76snuy	187	9	polymerization	polymerization	NN
cord-016938-pk76snuy	187	10	and	and	CC
cord-016938-pk76snuy	187	11	provide	provide	VB
cord-016938-pk76snuy	187	12	active	active	JJ
cord-016938-pk76snuy	187	13	species	specie	NNS
cord-016938-pk76snuy	187	14	which	which	WDT
cord-016938-pk76snuy	187	15	initiate	initiate	VBP
cord-016938-pk76snuy	187	16	graft	graft	NN
cord-016938-pk76snuy	187	17	polymerization	polymerization	NN
cord-016938-pk76snuy	187	18	by	by	IN
cord-016938-pk76snuy	187	19	reacting	react	VBG
cord-016938-pk76snuy	187	20	with	with	IN
cord-016938-pk76snuy	187	21	amines	amine	NNS
cord-016938-pk76snuy	187	22	in	in	IN
cord-016938-pk76snuy	187	23	the	the	DT
cord-016938-pk76snuy	187	24	collagen	collagen	NN
cord-016938-pk76snuy	187	25	molecules	molecule	NNS
cord-016938-pk76snuy	187	26	.	.	.
cord-016938-pk76snuy	188	1	Ozone	ozone	NN
cord-016938-pk76snuy	188	2	oxidation	oxidation	NN
cord-016938-pk76snuy	188	3	time	time	NN
cord-016938-pk76snuy	188	4	and	and	CC
cord-016938-pk76snuy	188	5	voltage	voltage	NN
cord-016938-pk76snuy	188	6	could	could	MD
cord-016938-pk76snuy	188	7	readily	readily	RB
cord-016938-pk76snuy	188	8	control	control	VB
cord-016938-pk76snuy	188	9	the	the	DT
cord-016938-pk76snuy	188	10	amount	amount	NN
cord-016938-pk76snuy	188	11	of	of	IN
cord-016938-pk76snuy	188	12	peroxide	peroxide	NN
cord-016938-pk76snuy	188	13	production	production	NN
cord-016938-pk76snuy	188	14	.	.	.
cord-016938-pk76snuy	189	1	Maximum	maximum	JJ
cord-016938-pk76snuy	189	2	concentration	concentration	NN
cord-016938-pk76snuy	189	3	of	of	IN
cord-016938-pk76snuy	189	4	peroxide	peroxide	NN
cord-016938-pk76snuy	189	5	was	be	VBD
cord-016938-pk76snuy	189	6	about	about	RB
cord-016938-pk76snuy	189	7	10.20	10.20	CD
cord-016938-pk76snuy	189	8	×10	×10	NFP
cord-016938-pk76snuy	189	9	−8	−8	NNP
cord-016938-pk76snuy	189	10	mol	mol	NNP
cord-016938-pk76snuy	189	11	/	/	SYM
cord-016938-pk76snuy	189	12	cm	cm	NNP
cord-016938-pk76snuy	189	13	2	2	CD
cord-016938-pk76snuy	189	14	when	when	WRB
cord-016938-pk76snuy	189	15	ozone	ozone	NN
cord-016938-pk76snuy	189	16	oxidation	oxidation	NN
cord-016938-pk76snuy	189	17	was	be	VBD
cord-016938-pk76snuy	189	18	performed	perform	VBN
cord-016938-pk76snuy	189	19	at	at	IN
cord-016938-pk76snuy	189	20	60	60	CD
cord-016938-pk76snuy	189	21	V	v	NN
cord-016938-pk76snuy	189	22	for	for	IN
cord-016938-pk76snuy	189	23	30	30	CD
cord-016938-pk76snuy	189	24	min	min	NN
cord-016938-pk76snuy	189	25	.	.	.
cord-016938-pk76snuy	190	1	After	after	IN
cord-016938-pk76snuy	190	2	the	the	DT
cord-016938-pk76snuy	190	3	reaction	reaction	NN
cord-016938-pk76snuy	190	4	of	of	IN
cord-016938-pk76snuy	190	5	PU	PU	NNP
cord-016938-pk76snuy	190	6	by	by	IN
cord-016938-pk76snuy	190	7	ozone	ozone	NN
cord-016938-pk76snuy	190	8	oxidation	oxidation	NN
cord-016938-pk76snuy	190	9	,	,	,
cord-016938-pk76snuy	190	10	type	type	NN
cord-016938-pk76snuy	191	1	I	-PRON-	PRP
cord-016938-pk76snuy	191	2	atelocollagen	atelocollagen	VBP
cord-016938-pk76snuy	191	3	gel	gel	NN
cord-016938-pk76snuy	191	4	was	be	VBD
cord-016938-pk76snuy	191	5	graft	graft	NN
cord-016938-pk76snuy	191	6	copolymerized	copolymerize	VBN
cord-016938-pk76snuy	191	7	onto	onto	IN
cord-016938-pk76snuy	191	8	the	the	DT
cord-016938-pk76snuy	191	9	PU	PU	NNP
cord-016938-pk76snuy	191	10	.	.	.
cord-016938-pk76snuy	192	1	All	all	PDT
cord-016938-pk76snuy	192	2	the	the	DT
cord-016938-pk76snuy	192	3	physical	physical	JJ
cord-016938-pk76snuy	192	4	measurements	measurement	NNS
cord-016938-pk76snuy	192	5	on	on	IN
cord-016938-pk76snuy	192	6	the	the	DT
cord-016938-pk76snuy	192	7	collagen	collagen	NN
cord-016938-pk76snuy	192	8	grafted	graft	VBN
cord-016938-pk76snuy	192	9	surface	surface	NN
cord-016938-pk76snuy	192	10	indicated	indicate	VBD
cord-016938-pk76snuy	192	11	that	that	IN
cord-016938-pk76snuy	192	12	the	the	DT
cord-016938-pk76snuy	192	13	PU	PU	NNP
cord-016938-pk76snuy	192	14	surface	surface	NN
cord-016938-pk76snuy	192	15	was	be	VBD
cord-016938-pk76snuy	192	16	effectively	effectively	RB
cord-016938-pk76snuy	192	17	covered	cover	VBN
cord-016938-pk76snuy	192	18	with	with	IN
cord-016938-pk76snuy	192	19	type	type	NN
cord-016938-pk76snuy	192	20	I	-PRON-	PRP
cord-016938-pk76snuy	192	21	atelocollagen	atelocollagen	VBD
cord-016938-pk76snuy	192	22	.	.	.
cord-016938-pk76snuy	193	1	Interaction	interaction	NN
cord-016938-pk76snuy	193	2	of	of	IN
cord-016938-pk76snuy	193	3	the	the	DT
cord-016938-pk76snuy	193	4	collagen	collagen	NN
cord-016938-pk76snuy	193	5	grafted	graft	VBN
cord-016938-pk76snuy	193	6	PU	PU	NNP
cord-016938-pk76snuy	193	7	surface	surface	NN
cord-016938-pk76snuy	193	8	with	with	IN
cord-016938-pk76snuy	193	9	fibroblasts	fibroblast	NNS
cord-016938-pk76snuy	193	10	could	could	MD
cord-016938-pk76snuy	193	11	be	be	VB
cord-016938-pk76snuy	193	12	greatly	greatly	RB
cord-016938-pk76snuy	193	13	enhanced	enhance	VBN
cord-016938-pk76snuy	193	14	by	by	IN
cord-016938-pk76snuy	193	15	the	the	DT
cord-016938-pk76snuy	193	16	surface	surface	NN
cord-016938-pk76snuy	193	17	graft	graft	NN
cord-016938-pk76snuy	193	18	polymerization	polymerization	NN
cord-016938-pk76snuy	193	19	with	with	IN
cord-016938-pk76snuy	193	20	type	type	NN
cord-016938-pk76snuy	193	21	I	-PRON-	PRP
cord-016938-pk76snuy	193	22	atelocollagen	atelocollagen	VBD
cord-016938-pk76snuy	193	23	.	.	.
cord-016938-pk76snuy	194	1	Attachment	attachment	NN
cord-016938-pk76snuy	194	2	and	and	CC
cord-016938-pk76snuy	194	3	proliferation	proliferation	NN
cord-016938-pk76snuy	194	4	of	of	IN
cord-016938-pk76snuy	194	5	fibroblasts	fibroblast	NNS
cord-016938-pk76snuy	194	6	on	on	IN
cord-016938-pk76snuy	194	7	the	the	DT
cord-016938-pk76snuy	194	8	grafted	grafted	JJ
cord-016938-pk76snuy	194	9	type	type	NN
cord-016938-pk76snuy	195	1	I	-PRON-	PRP
cord-016938-pk76snuy	195	2	atelocollagen	atelocollagen	NNP
cord-016938-pk76snuy	195	3	were	be	VBD
cord-016938-pk76snuy	195	4	significantly	significantly	RB
cord-016938-pk76snuy	195	5	enhanced	enhance	VBN
cord-016938-pk76snuy	195	6	,	,	,
cord-016938-pk76snuy	195	7	and	and	CC
cord-016938-pk76snuy	195	8	it	-PRON-	PRP
cord-016938-pk76snuy	195	9	is	be	VBZ
cord-016938-pk76snuy	195	10	assumed	assume	VBN
cord-016938-pk76snuy	195	11	that	that	IN
cord-016938-pk76snuy	195	12	the	the	DT
cord-016938-pk76snuy	195	13	atelocollagen	atelocollagen	NNP
cord-016938-pk76snuy	195	14	matrix	matrix	NN
cord-016938-pk76snuy	195	15	supported	support	VBD
cord-016938-pk76snuy	195	16	the	the	DT
cord-016938-pk76snuy	195	17	initial	initial	JJ
cord-016938-pk76snuy	195	18	attachment	attachment	NN
cord-016938-pk76snuy	195	19	and	and	CC
cord-016938-pk76snuy	195	20	growth	growth	NN
cord-016938-pk76snuy	195	21	of	of	IN
cord-016938-pk76snuy	195	22	cells	cell	NNS
cord-016938-pk76snuy	195	23	.	.	.
cord-016938-pk76snuy	196	1	In	in	IN
cord-016938-pk76snuy	196	2	the	the	DT
cord-016938-pk76snuy	196	3	early	early	JJ
cord-016938-pk76snuy	196	4	stage	stage	NN
cord-016938-pk76snuy	196	5	of	of	IN
cord-016938-pk76snuy	196	6	proliferation	proliferation	NN
cord-016938-pk76snuy	196	7	,	,	,
cord-016938-pk76snuy	196	8	collagen	collagen	NN
cord-016938-pk76snuy	196	9	synthesis	synthesis	NN
cord-016938-pk76snuy	196	10	in	in	IN
cord-016938-pk76snuy	196	11	fibroblasts	fibroblast	NNS
cord-016938-pk76snuy	196	12	was	be	VBD
cord-016938-pk76snuy	196	13	not	not	RB
cord-016938-pk76snuy	196	14	activated	activate	VBN
cord-016938-pk76snuy	196	15	and	and	CC
cord-016938-pk76snuy	196	16	remained	remain	VBD
cord-016938-pk76snuy	196	17	at	at	IN
cord-016938-pk76snuy	196	18	a	a	DT
cord-016938-pk76snuy	196	19	relatively	relatively	RB
cord-016938-pk76snuy	196	20	low	low	JJ
cord-016938-pk76snuy	196	21	level	level	NN
cord-016938-pk76snuy	196	22	due	due	IN
cord-016938-pk76snuy	196	23	to	to	IN
cord-016938-pk76snuy	196	24	the	the	DT
cord-016938-pk76snuy	196	25	grafted	grafted	JJ
cord-016938-pk76snuy	196	26	type	type	NN
cord-016938-pk76snuy	196	27	I	-PRON-	PRP
cord-016938-pk76snuy	196	28	atelocollagen	atelocollagen	VBD
cord-016938-pk76snuy	196	29	,	,	,
cord-016938-pk76snuy	196	30	increasing	increase	VBG
cord-016938-pk76snuy	196	31	only	only	JJ
cord-016938-pk76snuy	196	32	fibroblast	fibroblast	NN
cord-016938-pk76snuy	196	33	differentiation	differentiation	NN
cord-016938-pk76snuy	196	34	.	.	.
cord-016938-pk76snuy	197	1	The	the	DT
cord-016938-pk76snuy	197	2	mechanical	mechanical	JJ
cord-016938-pk76snuy	197	3	property	property	NN
cord-016938-pk76snuy	197	4	of	of	IN
cord-016938-pk76snuy	197	5	tubular	tubular	JJ
cord-016938-pk76snuy	197	6	tissue	tissue	NN
cord-016938-pk76snuy	197	7	was	be	VBD
cord-016938-pk76snuy	197	8	oriented	orient	VBN
cord-016938-pk76snuy	197	9	from	from	IN
cord-016938-pk76snuy	197	10	the	the	DT
cord-016938-pk76snuy	197	11	alignment	alignment	NN
cord-016938-pk76snuy	197	12	of	of	IN
cord-016938-pk76snuy	197	13	cells	cell	NNS
cord-016938-pk76snuy	197	14	that	that	WDT
cord-016938-pk76snuy	197	15	consists	consist	VBZ
cord-016938-pk76snuy	197	16	of	of	IN
cord-016938-pk76snuy	197	17	repeated	repeat	VBN
cord-016938-pk76snuy	197	18	overlayers	overlayer	NNS
cord-016938-pk76snuy	197	19	of	of	IN
cord-016938-pk76snuy	197	20	longitudinal	longitudinal	JJ
cord-016938-pk76snuy	197	21	and	and	CC
cord-016938-pk76snuy	197	22	circumferential	circumferential	JJ
cord-016938-pk76snuy	197	23	layers	layer	NNS
cord-016938-pk76snuy	197	24	and	and	CC
cord-016938-pk76snuy	197	25	forms	form	VBZ
cord-016938-pk76snuy	197	26	wall	wall	NN
cord-016938-pk76snuy	197	27	thickness	thickness	NN
cord-016938-pk76snuy	197	28	.	.	.
cord-016938-pk76snuy	198	1	Regarding	regard	VBG
cord-016938-pk76snuy	198	2	this	this	DT
cord-016938-pk76snuy	198	3	result	result	NN
cord-016938-pk76snuy	198	4	,	,	,
cord-016938-pk76snuy	198	5	a	a	DT
cord-016938-pk76snuy	198	6	double	double	JJ
cord-016938-pk76snuy	198	7	layered	layer	VBN
cord-016938-pk76snuy	198	8	PU	PU	NNP
cord-016938-pk76snuy	198	9	tubular	tubular	JJ
cord-016938-pk76snuy	198	10	scaffold	scaffold	NN
cord-016938-pk76snuy	198	11	grafted	graft	VBN
cord-016938-pk76snuy	198	12	with	with	IN
cord-016938-pk76snuy	198	13	collagen	collagen	NN
cord-016938-pk76snuy	198	14	was	be	VBD
cord-016938-pk76snuy	198	15	fabricated	fabricate	VBN
cord-016938-pk76snuy	198	16	to	to	TO
cord-016938-pk76snuy	198	17	produce	produce	VB
cord-016938-pk76snuy	198	18	an	an	DT
cord-016938-pk76snuy	198	19	artificial	artificial	JJ
cord-016938-pk76snuy	198	20	esophagus	esophagus	NN
cord-016938-pk76snuy	198	21	.	.	.
cord-016938-pk76snuy	199	1	PU	PU	NNP
cord-016938-pk76snuy	199	2	purification	purification	NN
cord-016938-pk76snuy	199	3	was	be	VBD
cord-016938-pk76snuy	199	4	performed	perform	VBN
cord-016938-pk76snuy	199	5	by	by	IN
cord-016938-pk76snuy	199	6	diluting	dilute	VBG
cord-016938-pk76snuy	199	7	PU	PU	NNP
cord-016938-pk76snuy	199	8	particles	particle	NNS
cord-016938-pk76snuy	199	9	in	in	IN
cord-016938-pk76snuy	199	10	DMAC(dimethyl	DMAC(dimethyl	NNP
cord-016938-pk76snuy	199	11	-	-	HYPH
cord-016938-pk76snuy	199	12	acrylamide	acrylamide	NN
cord-016938-pk76snuy	199	13	)	)	-RRB-
cord-016938-pk76snuy	199	14	solution	solution	NN
cord-016938-pk76snuy	199	15	then	then	RB
cord-016938-pk76snuy	199	16	precipitating	precipitate	VBG
cord-016938-pk76snuy	199	17	in	in	IN
cord-016938-pk76snuy	199	18	non	non	JJ
cord-016938-pk76snuy	199	19	-	-	JJ
cord-016938-pk76snuy	199	20	solvent	solvent	JJ
cord-016938-pk76snuy	199	21	methanol	methanol	NN
cord-016938-pk76snuy	199	22	,	,	,
cord-016938-pk76snuy	199	23	and	and	CC
cord-016938-pk76snuy	199	24	drying	dry	VBG
cord-016938-pk76snuy	199	25	the	the	DT
cord-016938-pk76snuy	199	26	precipitate	precipitate	NN
cord-016938-pk76snuy	199	27	under	under	IN
cord-016938-pk76snuy	199	28	vacuum	vacuum	NN
cord-016938-pk76snuy	199	29	for	for	IN
cord-016938-pk76snuy	199	30	2	2	CD
cord-016938-pk76snuy	199	31	days	day	NNS
cord-016938-pk76snuy	199	32	to	to	TO
cord-016938-pk76snuy	199	33	remove	remove	VB
cord-016938-pk76snuy	199	34	residual	residual	JJ
cord-016938-pk76snuy	199	35	methanol	methanol	NN
cord-016938-pk76snuy	199	36	.	.	.
cord-016938-pk76snuy	200	1	After	after	IN
cord-016938-pk76snuy	200	2	purification	purification	NN
cord-016938-pk76snuy	200	3	,	,	,
cord-016938-pk76snuy	200	4	PU	PU	NNP
cord-016938-pk76snuy	200	5	was	be	VBD
cord-016938-pk76snuy	200	6	dissolved	dissolve	VBN
cord-016938-pk76snuy	200	7	in	in	IN
cord-016938-pk76snuy	200	8	DMAC	DMAC	NNP
cord-016938-pk76snuy	200	9	solution	solution	NN
cord-016938-pk76snuy	200	10	at	at	IN
cord-016938-pk76snuy	200	11	the	the	DT
cord-016938-pk76snuy	200	12	final	final	JJ
cord-016938-pk76snuy	200	13	concentration	concentration	NN
cord-016938-pk76snuy	200	14	of	of	IN
cord-016938-pk76snuy	200	15	13%w	13%w	CD
cord-016938-pk76snuy	200	16	/	/	SYM
cord-016938-pk76snuy	200	17	w	w	NN
cord-016938-pk76snuy	200	18	.	.	.
cord-016938-pk76snuy	201	1	Glass	glass	NN
cord-016938-pk76snuy	201	2	rod	rod	NN
cord-016938-pk76snuy	201	3	,	,	,
cord-016938-pk76snuy	201	4	with	with	IN
cord-016938-pk76snuy	201	5	diameter	diameter	NN
cord-016938-pk76snuy	201	6	of	of	IN
cord-016938-pk76snuy	201	7	3	3	CD
cord-016938-pk76snuy	201	8	mm	mm	NN
cord-016938-pk76snuy	201	9	and	and	CC
cord-016938-pk76snuy	201	10	length	length	NN
cord-016938-pk76snuy	201	11	of	of	IN
cord-016938-pk76snuy	201	12	15	15	CD
cord-016938-pk76snuy	201	13	cm	cm	NNS
cord-016938-pk76snuy	201	14	,	,	,
cord-016938-pk76snuy	201	15	was	be	VBD
cord-016938-pk76snuy	201	16	worn	wear	VBN
cord-016938-pk76snuy	201	17	with	with	IN
cord-016938-pk76snuy	201	18	13	13	CD
cord-016938-pk76snuy	201	19	%	%	NN
cord-016938-pk76snuy	201	20	PU	PU	NNP
cord-016938-pk76snuy	201	21	solution	solution	NN
cord-016938-pk76snuy	201	22	and	and	CC
cord-016938-pk76snuy	201	23	then	then	RB
cord-016938-pk76snuy	201	24	air	air	NN
cord-016938-pk76snuy	201	25	-	-	HYPH
cord-016938-pk76snuy	201	26	dried	dry	VBN
cord-016938-pk76snuy	201	27	for	for	IN
cord-016938-pk76snuy	201	28	6	6	CD
cord-016938-pk76snuy	201	29	hours	hour	NNS
cord-016938-pk76snuy	201	30	.	.	.
cord-016938-pk76snuy	202	1	This	this	DT
cord-016938-pk76snuy	202	2	process	process	NN
cord-016938-pk76snuy	202	3	was	be	VBD
cord-016938-pk76snuy	202	4	repeated	repeat	VBN
cord-016938-pk76snuy	202	5	twice	twice	RB
cord-016938-pk76snuy	202	6	.	.	.
cord-016938-pk76snuy	203	1	After	after	IN
cord-016938-pk76snuy	203	2	wearing	wear	VBG
cord-016938-pk76snuy	203	3	,	,	,
cord-016938-pk76snuy	203	4	an	an	DT
cord-016938-pk76snuy	203	5	end	end	NN
cord-016938-pk76snuy	203	6	part	part	NN
cord-016938-pk76snuy	203	7	of	of	IN
cord-016938-pk76snuy	203	8	the	the	DT
cord-016938-pk76snuy	203	9	glass	glass	NN
cord-016938-pk76snuy	203	10	rod	rod	NN
cord-016938-pk76snuy	203	11	was	be	VBD
cord-016938-pk76snuy	203	12	cut	cut	VBN
cord-016938-pk76snuy	203	13	,	,	,
cord-016938-pk76snuy	203	14	and	and	CC
cord-016938-pk76snuy	203	15	then	then	RB
cord-016938-pk76snuy	203	16	the	the	DT
cord-016938-pk76snuy	203	17	rod	rod	NN
cord-016938-pk76snuy	203	18	was	be	VBD
cord-016938-pk76snuy	203	19	worn	wear	VBN
cord-016938-pk76snuy	203	20	again	again	RB
cord-016938-pk76snuy	203	21	in	in	IN
cord-016938-pk76snuy	203	22	reverse	reverse	JJ
cord-016938-pk76snuy	203	23	direction	direction	NN
cord-016938-pk76snuy	203	24	by	by	IN
cord-016938-pk76snuy	203	25	the	the	DT
cord-016938-pk76snuy	203	26	same	same	JJ
cord-016938-pk76snuy	203	27	process	process	NN
cord-016938-pk76snuy	203	28	to	to	TO
cord-016938-pk76snuy	203	29	be	be	VB
cord-016938-pk76snuy	203	30	uniformly	uniformly	RB
cord-016938-pk76snuy	203	31	worn	wear	VBN
cord-016938-pk76snuy	203	32	.	.	.
cord-016938-pk76snuy	204	1	It	-PRON-	PRP
cord-016938-pk76snuy	204	2	was	be	VBD
cord-016938-pk76snuy	204	3	dried	dry	VBN
cord-016938-pk76snuy	204	4	under	under	IN
cord-016938-pk76snuy	204	5	vacuum	vacuum	NN
cord-016938-pk76snuy	204	6	for	for	IN
cord-016938-pk76snuy	204	7	12	12	CD
cord-016938-pk76snuy	204	8	hours	hour	NNS
cord-016938-pk76snuy	204	9	afterward	afterward	RB
cord-016938-pk76snuy	204	10	.	.	.
cord-016938-pk76snuy	205	1	Completely	completely	RB
cord-016938-pk76snuy	205	2	dried	dry	VBN
cord-016938-pk76snuy	205	3	sam-	sam-	XX
cord-016938-pk76snuy	205	4	ple	ple	NN
cord-016938-pk76snuy	205	5	was	be	VBD
cord-016938-pk76snuy	205	6	swelled	swell	VBN
cord-016938-pk76snuy	205	7	in	in	IN
cord-016938-pk76snuy	205	8	benzene	benzene	NN
cord-016938-pk76snuy	205	9	solution	solution	NN
cord-016938-pk76snuy	205	10	for	for	IN
cord-016938-pk76snuy	205	11	1	1	CD
cord-016938-pk76snuy	205	12	hour	hour	NN
cord-016938-pk76snuy	205	13	and	and	CC
cord-016938-pk76snuy	205	14	washed	wash	VBD
cord-016938-pk76snuy	205	15	with	with	IN
cord-016938-pk76snuy	205	16	distilled	distil	VBN
cord-016938-pk76snuy	205	17	water	water	NN
cord-016938-pk76snuy	205	18	for	for	IN
cord-016938-pk76snuy	205	19	2	2	CD
cord-016938-pk76snuy	205	20	hours	hour	NNS
cord-016938-pk76snuy	205	21	and	and	CC
cord-016938-pk76snuy	205	22	ethyl	ethyl	NN
cord-016938-pk76snuy	205	23	alcohol	alcohol	NN
cord-016938-pk76snuy	205	24	for	for	IN
cord-016938-pk76snuy	205	25	1	1	CD
cord-016938-pk76snuy	205	26	hour	hour	NN
cord-016938-pk76snuy	205	27	.	.	.
cord-016938-pk76snuy	206	1	After	after	IN
cord-016938-pk76snuy	206	2	swelling	swell	VBG
cord-016938-pk76snuy	206	3	and	and	CC
cord-016938-pk76snuy	206	4	wearing	wear	VBG
cord-016938-pk76snuy	206	5	process	process	NN
cord-016938-pk76snuy	206	6	,	,	,
cord-016938-pk76snuy	206	7	a	a	DT
cord-016938-pk76snuy	206	8	porous	porous	JJ
cord-016938-pk76snuy	206	9	PU	PU	NNP
cord-016938-pk76snuy	206	10	tube	tube	NN
cord-016938-pk76snuy	206	11	was	be	VBD
cord-016938-pk76snuy	206	12	separated	separate	VBN
cord-016938-pk76snuy	206	13	from	from	IN
cord-016938-pk76snuy	206	14	glass	glass	NN
cord-016938-pk76snuy	206	15	rod	rod	NN
cord-016938-pk76snuy	206	16	and	and	CC
cord-016938-pk76snuy	206	17	dried	dry	VBN
cord-016938-pk76snuy	206	18	under	under	IN
cord-016938-pk76snuy	206	19	vacuum	vacuum	NN
cord-016938-pk76snuy	206	20	.	.	.
cord-016938-pk76snuy	207	1	To	to	TO
cord-016938-pk76snuy	207	2	graft	graft	VB
cord-016938-pk76snuy	207	3	collagen	collagen	NN
cord-016938-pk76snuy	207	4	,	,	,
cord-016938-pk76snuy	207	5	ozone	ozone	NN
cord-016938-pk76snuy	207	6	treatment	treatment	NN
cord-016938-pk76snuy	207	7	was	be	VBD
cord-016938-pk76snuy	207	8	performed	perform	VBN
cord-016938-pk76snuy	207	9	as	as	IN
cord-016938-pk76snuy	207	10	described	describe	VBN
cord-016938-pk76snuy	207	11	above	above	RB
cord-016938-pk76snuy	207	12	.	.	.
cord-016938-pk76snuy	208	1	The	the	DT
cord-016938-pk76snuy	208	2	tube	tube	NN
cord-016938-pk76snuy	208	3	was	be	VBD
cord-016938-pk76snuy	208	4	immediately	immediately	RB
cord-016938-pk76snuy	208	5	immersed	immerse	VBN
cord-016938-pk76snuy	208	6	in	in	IN
cord-016938-pk76snuy	208	7	1	1	CD
cord-016938-pk76snuy	208	8	%	%	NN
cord-016938-pk76snuy	208	9	type	type	NN
cord-016938-pk76snuy	208	10	I	-PRON-	PRP
cord-016938-pk76snuy	208	11	atelocollagen	atelocollagen	VBP
cord-016938-pk76snuy	208	12	gel	gel	NN
cord-016938-pk76snuy	208	13	,	,	,
cord-016938-pk76snuy	208	14	and	and	CC
cord-016938-pk76snuy	208	15	Mohr	Mohr	NNP
cord-016938-pk76snuy	208	16	's	's	POS
cord-016938-pk76snuy	208	17	salt	salt	NN
cord-016938-pk76snuy	208	18	[	[	-LRB-
cord-016938-pk76snuy	208	19	FeSO	FeSO	NNP
cord-016938-pk76snuy	208	20	4	4	CD
cord-016938-pk76snuy	208	21	(	(	-LRB-
cord-016938-pk76snuy	208	22	NH	NH	NNP
cord-016938-pk76snuy	208	23	4	4	CD
cord-016938-pk76snuy	208	24	)	)	-RRB-
cord-016938-pk76snuy	208	25	2SO	2so	CD
cord-016938-pk76snuy	208	26	4	4	CD
cord-016938-pk76snuy	208	27	6H	6h	CD
cord-016938-pk76snuy	209	1	2	2	LS
cord-016938-pk76snuy	209	2	O	o	NN
cord-016938-pk76snuy	209	3	]	]	-RRB-
cord-016938-pk76snuy	209	4	was	be	VBD
cord-016938-pk76snuy	209	5	added	add	VBN
cord-016938-pk76snuy	209	6	to	to	IN
cord-016938-pk76snuy	209	7	the	the	DT
cord-016938-pk76snuy	209	8	gel	gel	NN
cord-016938-pk76snuy	209	9	to	to	TO
cord-016938-pk76snuy	209	10	decompose	decompose	VB
cord-016938-pk76snuy	209	11	peroxides	peroxide	NNS
cord-016938-pk76snuy	209	12	.	.	.
cord-016938-pk76snuy	210	1	Then	then	RB
cord-016938-pk76snuy	210	2	polymerization	polymerization	NN
cord-016938-pk76snuy	210	3	was	be	VBD
cord-016938-pk76snuy	210	4	allowed	allow	VBN
cord-016938-pk76snuy	210	5	to	to	TO
cord-016938-pk76snuy	210	6	proceed	proceed	VB
cord-016938-pk76snuy	210	7	at	at	IN
cord-016938-pk76snuy	210	8	35	35	CD
cord-016938-pk76snuy	210	9	•	•	NNS
cord-016938-pk76snuy	210	10	C	c	NN
cord-016938-pk76snuy	210	11	and	and	CC
cord-016938-pk76snuy	210	12	pH	pH	NNP
cord-016938-pk76snuy	210	13	8.0	8.0	CD
cord-016938-pk76snuy	210	14	.	.	.
cord-016938-pk76snuy	211	1	Type	type	NN
cord-016938-pk76snuy	211	2	I	-PRON-	PRP
cord-016938-pk76snuy	211	3	atelocollagen	atelocollagen	VBP
cord-016938-pk76snuy	211	4	grafted	graft	VBD
cord-016938-pk76snuy	211	5	porous	porous	JJ
cord-016938-pk76snuy	211	6	PU	PU	NNP
cord-016938-pk76snuy	211	7	tube	tube	NN
cord-016938-pk76snuy	211	8	was	be	VBD
cord-016938-pk76snuy	211	9	dried	dry	VBN
cord-016938-pk76snuy	211	10	in	in	IN
cord-016938-pk76snuy	211	11	vacuum	vacuum	NN
cord-016938-pk76snuy	211	12	at	at	IN
cord-016938-pk76snuy	211	13	25	25	CD
cord-016938-pk76snuy	211	14	•	•	NNS
cord-016938-pk76snuy	212	1	C.	C.	NNP
cord-016938-pk76snuy	213	1	The	the	DT
cord-016938-pk76snuy	213	2	tube	tube	NN
cord-016938-pk76snuy	213	3	was	be	VBD
cord-016938-pk76snuy	213	4	dipped	dip	VBN
cord-016938-pk76snuy	213	5	in	in	IN
cord-016938-pk76snuy	213	6	a	a	DT
cord-016938-pk76snuy	213	7	2	2	CD
cord-016938-pk76snuy	213	8	%	%	NN
cord-016938-pk76snuy	213	9	collagen	collagen	NN
cord-016938-pk76snuy	213	10	gel	gel	NN
cord-016938-pk76snuy	213	11	and	and	CC
cord-016938-pk76snuy	213	12	crosslinked	crosslinke	VBN
cord-016938-pk76snuy	213	13	by	by	IN
cord-016938-pk76snuy	213	14	EDC	EDC	NNP
cord-016938-pk76snuy	213	15	later	later	RB
cord-016938-pk76snuy	213	16	.	.	.
cord-016938-pk76snuy	214	1	By	by	IN
cord-016938-pk76snuy	214	2	this	this	DT
cord-016938-pk76snuy	214	3	procedure	procedure	NN
cord-016938-pk76snuy	214	4	,	,	,
cord-016938-pk76snuy	214	5	a	a	DT
cord-016938-pk76snuy	214	6	porous	porous	JJ
cord-016938-pk76snuy	214	7	collagen	collagen	NN
cord-016938-pk76snuy	214	8	-	-	HYPH
cord-016938-pk76snuy	214	9	grafted	graft	VBN
cord-016938-pk76snuy	214	10	tube	tube	NN
cord-016938-pk76snuy	214	11	with	with	IN
cord-016938-pk76snuy	214	12	inner	inner	JJ
cord-016938-pk76snuy	214	13	diameter	diameter	NN
cord-016938-pk76snuy	214	14	of	of	IN
cord-016938-pk76snuy	214	15	3	3	CD
cord-016938-pk76snuy	214	16	mm	mm	NN
cord-016938-pk76snuy	214	17	,	,	,
cord-016938-pk76snuy	214	18	thickness	thickness	NN
cord-016938-pk76snuy	214	19	of	of	IN
cord-016938-pk76snuy	214	20	0.7	0.7	CD
cord-016938-pk76snuy	214	21	mm	mm	NNS
cord-016938-pk76snuy	214	22	covered	cover	VBN
cord-016938-pk76snuy	214	23	by	by	IN
cord-016938-pk76snuy	214	24	dense	dense	JJ
cord-016938-pk76snuy	214	25	collagen	collagen	NN
cord-016938-pk76snuy	214	26	layer	layer	NN
cord-016938-pk76snuy	214	27	was	be	VBD
cord-016938-pk76snuy	214	28	produced	produce	VBN
cord-016938-pk76snuy	214	29	.	.	.
cord-016938-pk76snuy	215	1	Rabbit	Rabbit	NNP
cord-016938-pk76snuy	215	2	's	's	POS
cord-016938-pk76snuy	215	3	esophageal	esophageal	JJ
cord-016938-pk76snuy	215	4	smooth	smooth	JJ
cord-016938-pk76snuy	215	5	muscle	muscle	NN
cord-016938-pk76snuy	215	6	cells	cell	NNS
cord-016938-pk76snuy	215	7	were	be	VBD
cord-016938-pk76snuy	215	8	seeded	seed	VBN
cord-016938-pk76snuy	215	9	and	and	CC
cord-016938-pk76snuy	215	10	cultured	culture	VBN
cord-016938-pk76snuy	215	11	in	in	IN
cord-016938-pk76snuy	215	12	a	a	DT
cord-016938-pk76snuy	215	13	mechanically	mechanically	RB
cord-016938-pk76snuy	215	14	stressful	stressful	JJ
cord-016938-pk76snuy	215	15	environment	environment	NN
cord-016938-pk76snuy	215	16	of	of	IN
cord-016938-pk76snuy	215	17	10	10	CD
cord-016938-pk76snuy	215	18	%	%	NN
cord-016938-pk76snuy	215	19	strain	strain	NN
cord-016938-pk76snuy	215	20	magnitude	magnitude	NN
cord-016938-pk76snuy	215	21	and	and	CC
cord-016938-pk76snuy	215	22	1	1	CD
cord-016938-pk76snuy	215	23	Hz	Hz	NNP
cord-016938-pk76snuy	215	24	frequency	frequency	NN
cord-016938-pk76snuy	215	25	.	.	.
cord-016938-pk76snuy	216	1	Culturing	culture	VBG
cord-016938-pk76snuy	216	2	for	for	IN
cord-016938-pk76snuy	216	3	18	18	CD
cord-016938-pk76snuy	216	4	hours	hour	NNS
cord-016938-pk76snuy	216	5	of	of	IN
cord-016938-pk76snuy	216	6	mechanically	mechanically	RB
cord-016938-pk76snuy	216	7	stretching	stretch	VBG
cord-016938-pk76snuy	216	8	condition	condition	NN
cord-016938-pk76snuy	216	9	and	and	CC
cord-016938-pk76snuy	216	10	6	6	CD
cord-016938-pk76snuy	216	11	hours	hour	NNS
cord-016938-pk76snuy	216	12	of	of	IN
cord-016938-pk76snuy	216	13	stationary	stationary	JJ
cord-016938-pk76snuy	216	14	condition	condition	NN
cord-016938-pk76snuy	216	15	on	on	IN
cord-016938-pk76snuy	216	16	every	every	DT
cord-016938-pk76snuy	216	17	24-hour	24-hour	JJ
cord-016938-pk76snuy	216	18	period	period	NN
cord-016938-pk76snuy	216	19	,	,	,
cord-016938-pk76snuy	216	20	the	the	DT
cord-016938-pk76snuy	216	21	cultured	cultured	JJ
cord-016938-pk76snuy	216	22	cells	cell	NNS
cord-016938-pk76snuy	216	23	aligned	align	VBN
cord-016938-pk76snuy	216	24	in	in	IN
cord-016938-pk76snuy	216	25	the	the	DT
cord-016938-pk76snuy	216	26	perpendicular	perpendicular	JJ
cord-016938-pk76snuy	216	27	direction	direction	NN
cord-016938-pk76snuy	216	28	to	to	IN
cord-016938-pk76snuy	216	29	the	the	DT
cord-016938-pk76snuy	216	30	strain	strain	NN
cord-016938-pk76snuy	216	31	direction	direction	NN
cord-016938-pk76snuy	216	32	after	after	IN
cord-016938-pk76snuy	216	33	2	2	CD
cord-016938-pk76snuy	216	34	days	day	NNS
cord-016938-pk76snuy	216	35	.	.	.
cord-016938-pk76snuy	217	1	The	the	DT
cord-016938-pk76snuy	217	2	collagen	collagen	NN
cord-016938-pk76snuy	217	3	grafted	graft	VBD
cord-016938-pk76snuy	217	4	PU	PU	NNP
cord-016938-pk76snuy	217	5	tube	tube	NN
cord-016938-pk76snuy	217	6	with	with	IN
cord-016938-pk76snuy	217	7	cell	cell	NN
cord-016938-pk76snuy	217	8	alignment	alignment	NN
cord-016938-pk76snuy	217	9	control	control	NN
cord-016938-pk76snuy	217	10	was	be	VBD
cord-016938-pk76snuy	217	11	subcutaneously	subcutaneously	RB
cord-016938-pk76snuy	217	12	implanted	implant	VBN
cord-016938-pk76snuy	217	13	in	in	IN
cord-016938-pk76snuy	217	14	nude	nude	JJ
cord-016938-pk76snuy	217	15	mice	mouse	NNS
cord-016938-pk76snuy	217	16	for	for	IN
cord-016938-pk76snuy	217	17	4	4	CD
cord-016938-pk76snuy	217	18	weeks	week	NNS
cord-016938-pk76snuy	217	19	,	,	,
cord-016938-pk76snuy	217	20	and	and	CC
cord-016938-pk76snuy	217	21	a	a	DT
cord-016938-pk76snuy	217	22	histological	histological	JJ
cord-016938-pk76snuy	217	23	finding	finding	NN
cord-016938-pk76snuy	217	24	demonstrated	demonstrate	VBD
cord-016938-pk76snuy	217	25	that	that	IN
cord-016938-pk76snuy	217	26	a	a	DT
cord-016938-pk76snuy	217	27	well	well	RB
cord-016938-pk76snuy	217	28	-	-	HYPH
cord-016938-pk76snuy	217	29	aligned	align	VBN
cord-016938-pk76snuy	217	30	smooth	smooth	JJ
cord-016938-pk76snuy	217	31	muscle	muscle	NN
cord-016938-pk76snuy	217	32	cells	cell	NNS
cord-016938-pk76snuy	217	33	reconstructed	reconstruct	VBD
cord-016938-pk76snuy	217	34	the	the	DT
cord-016938-pk76snuy	217	35	tube	tube	NN
cord-016938-pk76snuy	217	36	which	which	WDT
cord-016938-pk76snuy	217	37	is	be	VBZ
cord-016938-pk76snuy	217	38	applicable	applicable	JJ
cord-016938-pk76snuy	217	39	for	for	IN
cord-016938-pk76snuy	217	40	replacement	replacement	NN
cord-016938-pk76snuy	217	41	of	of	IN
cord-016938-pk76snuy	217	42	esophagus	esophagus	NN
cord-016938-pk76snuy	217	43	[	[	-LRB-
cord-016938-pk76snuy	217	44	26	26	CD
cord-016938-pk76snuy	217	45	]	]	-RRB-
cord-016938-pk76snuy	218	1	[	[	-LRB-
cord-016938-pk76snuy	218	2	27	27	CD
cord-016938-pk76snuy	218	3	]	]	-RRB-
cord-016938-pk76snuy	218	4	[	[	-LRB-
cord-016938-pk76snuy	218	5	28	28	CD
cord-016938-pk76snuy	218	6	]	]	-RRB-
cord-016938-pk76snuy	218	7	[	[	-LRB-
cord-016938-pk76snuy	218	8	29	29	CD
cord-016938-pk76snuy	218	9	]	]	-RRB-
cord-016938-pk76snuy	219	1	[	[	-LRB-
cord-016938-pk76snuy	219	2	30	30	CD
cord-016938-pk76snuy	219	3	]	]	-RRB-
cord-016938-pk76snuy	219	4	 	 	_SP
cord-016938-pk76snuy	220	1	The	the	DT
cord-016938-pk76snuy	220	2	idea	idea	NN
cord-016938-pk76snuy	220	3	of	of	IN
cord-016938-pk76snuy	220	4	collagen	collagen	NN
cord-016938-pk76snuy	220	5	grafting	grafting	NN
cord-016938-pk76snuy	220	6	was	be	VBD
cord-016938-pk76snuy	220	7	also	also	RB
cord-016938-pk76snuy	220	8	applied	apply	VBN
cord-016938-pk76snuy	220	9	to	to	TO
cord-016938-pk76snuy	220	10	produce	produce	VB
cord-016938-pk76snuy	220	11	a	a	DT
cord-016938-pk76snuy	220	12	healing	healing	NN
cord-016938-pk76snuy	220	13	-	-	HYPH
cord-016938-pk76snuy	220	14	promoting	promote	VBG
cord-016938-pk76snuy	220	15	antiadhesive	antiadhesive	JJ
cord-016938-pk76snuy	220	16	membrane	membrane	NN
cord-016938-pk76snuy	220	17	that	that	WDT
cord-016938-pk76snuy	220	18	is	be	VBZ
cord-016938-pk76snuy	220	19	particularly	particularly	RB
cord-016938-pk76snuy	220	20	necessary	necessary	JJ
cord-016938-pk76snuy	220	21	in	in	IN
cord-016938-pk76snuy	220	22	peritoneal	peritoneal	JJ
cord-016938-pk76snuy	220	23	surgery	surgery	NN
cord-016938-pk76snuy	220	24	to	to	TO
cord-016938-pk76snuy	220	25	prevent	prevent	VB
cord-016938-pk76snuy	220	26	postoperative	postoperative	JJ
cord-016938-pk76snuy	220	27	adhesion	adhesion	NN
cord-016938-pk76snuy	220	28	.	.	.
cord-016938-pk76snuy	221	1	At	at	IN
cord-016938-pk76snuy	221	2	first	first	RB
cord-016938-pk76snuy	221	3	,	,	,
cord-016938-pk76snuy	221	4	glycolide	glycolide	NNP
cord-016938-pk76snuy	221	5	and	and	CC
cord-016938-pk76snuy	221	6	D	D	NNP
cord-016938-pk76snuy	221	7	,	,	,
cord-016938-pk76snuy	221	8	L	l	NN
cord-016938-pk76snuy	221	9	-	-	HYPH
cord-016938-pk76snuy	221	10	lactide	lactide	NNP
cord-016938-pk76snuy	221	11	were	be	VBD
cord-016938-pk76snuy	221	12	recrystallized	recrystallize	VBN
cord-016938-pk76snuy	221	13	from	from	IN
cord-016938-pk76snuy	221	14	ethyl	ethyl	NN
cord-016938-pk76snuy	221	15	acetate	acetate	NN
cord-016938-pk76snuy	221	16	and	and	CC
cord-016938-pk76snuy	221	17	dried	dry	VBN
cord-016938-pk76snuy	221	18	under	under	IN
cord-016938-pk76snuy	221	19	vacuum	vacuum	NN
cord-016938-pk76snuy	221	20	before	before	IN
cord-016938-pk76snuy	221	21	use	use	NN
cord-016938-pk76snuy	221	22	.	.	.
cord-016938-pk76snuy	222	1	Lactide	Lactide	NNP
cord-016938-pk76snuy	222	2	and	and	CC
cord-016938-pk76snuy	222	3	glycolide	glycolide	NNP
cord-016938-pk76snuy	222	4	,	,	,
cord-016938-pk76snuy	222	5	at	at	IN
cord-016938-pk76snuy	222	6	a	a	DT
cord-016938-pk76snuy	222	7	molar	molar	JJ
cord-016938-pk76snuy	222	8	ratio	ratio	NN
cord-016938-pk76snuy	222	9	of	of	IN
cord-016938-pk76snuy	222	10	75:25	75:25	CD
cord-016938-pk76snuy	222	11	,	,	,
cord-016938-pk76snuy	222	12	were	be	VBD
cord-016938-pk76snuy	222	13	put	put	VBN
cord-016938-pk76snuy	222	14	into	into	IN
cord-016938-pk76snuy	222	15	a	a	DT
cord-016938-pk76snuy	222	16	glass	glass	NN
cord-016938-pk76snuy	222	17	ampoule	ampoule	NN
cord-016938-pk76snuy	222	18	,	,	,
cord-016938-pk76snuy	222	19	and	and	CC
cord-016938-pk76snuy	222	20	mPEG	mPEG	NNP
cord-016938-pk76snuy	222	21	was	be	VBD
cord-016938-pk76snuy	222	22	added	add	VBN
cord-016938-pk76snuy	222	23	for	for	IN
cord-016938-pk76snuy	222	24	preparing	prepare	VBG
cord-016938-pk76snuy	222	25	the	the	DT
cord-016938-pk76snuy	222	26	mPEG	mPEG	NNP
cord-016938-pk76snuy	222	27	-	-	HYPH
cord-016938-pk76snuy	222	28	PLGA	PLGA	NNP
cord-016938-pk76snuy	222	29	block	block	NN
cord-016938-pk76snuy	222	30	copolymer	copolymer	NN
cord-016938-pk76snuy	222	31	through	through	IN
cord-016938-pk76snuy	222	32	ring	ring	NN
cord-016938-pk76snuy	222	33	-	-	HYPH
cord-016938-pk76snuy	222	34	opening	open	VBG
cord-016938-pk76snuy	222	35	polymerization	polymerization	NN
cord-016938-pk76snuy	222	36	.	.	.
cord-016938-pk76snuy	223	1	0.05%(w	0.05%(w	LS
cord-016938-pk76snuy	223	2	/	/	SYM
cord-016938-pk76snuy	223	3	w	w	NN
cord-016938-pk76snuy	223	4	)	)	-RRB-
cord-016938-pk76snuy	223	5	of	of	IN
cord-016938-pk76snuy	223	6	stannous	stannous	JJ
cord-016938-pk76snuy	223	7	octoate	octoate	NNP
cord-016938-pk76snuy	223	8	added	add	VBD
cord-016938-pk76snuy	223	9	to	to	IN
cord-016938-pk76snuy	223	10	the	the	DT
cord-016938-pk76snuy	223	11	solution	solution	NN
cord-016938-pk76snuy	223	12	as	as	IN
cord-016938-pk76snuy	223	13	a	a	DT
cord-016938-pk76snuy	223	14	catalyst	catalyst	NN
cord-016938-pk76snuy	223	15	.	.	.
cord-016938-pk76snuy	224	1	The	the	DT
cord-016938-pk76snuy	224	2	ampoule	ampoule	NN
cord-016938-pk76snuy	224	3	was	be	VBD
cord-016938-pk76snuy	224	4	evacuated	evacuate	VBN
cord-016938-pk76snuy	224	5	by	by	IN
cord-016938-pk76snuy	224	6	a	a	DT
cord-016938-pk76snuy	224	7	vacuum	vacuum	NN
cord-016938-pk76snuy	224	8	pump	pump	NN
cord-016938-pk76snuy	224	9	,	,	,
cord-016938-pk76snuy	224	10	sealed	seal	VBN
cord-016938-pk76snuy	224	11	with	with	IN
cord-016938-pk76snuy	224	12	a	a	DT
cord-016938-pk76snuy	224	13	torch	torch	NN
cord-016938-pk76snuy	224	14	,	,	,
cord-016938-pk76snuy	224	15	and	and	CC
cord-016938-pk76snuy	224	16	was	be	VBD
cord-016938-pk76snuy	224	17	heated	heat	VBN
cord-016938-pk76snuy	224	18	in	in	IN
cord-016938-pk76snuy	224	19	an	an	DT
cord-016938-pk76snuy	224	20	oil	oil	NN
cord-016938-pk76snuy	224	21	bath	bath	NN
cord-016938-pk76snuy	224	22	at	at	IN
cord-016938-pk76snuy	224	23	130	130	CD
cord-016938-pk76snuy	224	24	•	•	NN
cord-016938-pk76snuy	224	25	C	c	NN
cord-016938-pk76snuy	224	26	for	for	IN
cord-016938-pk76snuy	224	27	12	12	CD
cord-016938-pk76snuy	224	28	hrs	hrs	NN
cord-016938-pk76snuy	224	29	.	.	.
cord-016938-pk76snuy	225	1	After	after	IN
cord-016938-pk76snuy	225	2	the	the	DT
cord-016938-pk76snuy	225	3	reaction	reaction	NN
cord-016938-pk76snuy	225	4	was	be	VBD
cord-016938-pk76snuy	225	5	complete	complete	JJ
cord-016938-pk76snuy	225	6	,	,	,
cord-016938-pk76snuy	225	7	resulting	result	VBG
cord-016938-pk76snuy	225	8	polymers	polymer	NNS
cord-016938-pk76snuy	225	9	were	be	VBD
cord-016938-pk76snuy	225	10	purified	purify	VBN
cord-016938-pk76snuy	225	11	by	by	IN
cord-016938-pk76snuy	225	12	dissolving	dissolve	VBG
cord-016938-pk76snuy	225	13	in	in	IN
cord-016938-pk76snuy	225	14	methylene	methylene	NN
cord-016938-pk76snuy	225	15	chloride	chloride	NN
cord-016938-pk76snuy	225	16	and	and	CC
cord-016938-pk76snuy	225	17	then	then	RB
cord-016938-pk76snuy	225	18	precipitated	precipitate	VBD
cord-016938-pk76snuy	225	19	in	in	IN
cord-016938-pk76snuy	225	20	excess	excess	JJ
cord-016938-pk76snuy	225	21	methanol	methanol	NN
cord-016938-pk76snuy	225	22	.	.	.
cord-016938-pk76snuy	226	1	Obtained	obtain	VBN
cord-016938-pk76snuy	226	2	polymers	polymer	NNS
cord-016938-pk76snuy	226	3	were	be	VBD
cord-016938-pk76snuy	226	4	dried	dry	VBN
cord-016938-pk76snuy	226	5	in	in	IN
cord-016938-pk76snuy	226	6	vacuum	vacuum	NN
cord-016938-pk76snuy	226	7	.	.	.
cord-016938-pk76snuy	227	1	For	for	IN
cord-016938-pk76snuy	227	2	the	the	DT
cord-016938-pk76snuy	227	3	preparation	preparation	NN
cord-016938-pk76snuy	227	4	of	of	IN
cord-016938-pk76snuy	227	5	polymer	polymer	NN
cord-016938-pk76snuy	227	6	film	film	NN
cord-016938-pk76snuy	227	7	,	,	,
cord-016938-pk76snuy	227	8	8	8	CD
cord-016938-pk76snuy	227	9	%	%	NN
cord-016938-pk76snuy	227	10	solution	solution	NN
cord-016938-pk76snuy	227	11	of	of	IN
cord-016938-pk76snuy	227	12	mPEG	mPEG	NNP
cord-016938-pk76snuy	227	13	-	-	HYPH
cord-016938-pk76snuy	227	14	PLGA	PLGA	NNP
cord-016938-pk76snuy	227	15	in	in	IN
cord-016938-pk76snuy	227	16	chloroform	chloroform	NN
cord-016938-pk76snuy	227	17	was	be	VBD
cord-016938-pk76snuy	227	18	cast	cast	VBN
cord-016938-pk76snuy	227	19	on	on	IN
cord-016938-pk76snuy	227	20	a	a	DT
cord-016938-pk76snuy	227	21	glass	glass	NN
cord-016938-pk76snuy	227	22	plate	plate	NN
cord-016938-pk76snuy	227	23	,	,	,
cord-016938-pk76snuy	227	24	and	and	CC
cord-016938-pk76snuy	227	25	the	the	DT
cord-016938-pk76snuy	227	26	solvent	solvent	NN
cord-016938-pk76snuy	227	27	was	be	VBD
cord-016938-pk76snuy	227	28	evaporated	evaporate	VBN
cord-016938-pk76snuy	227	29	in	in	IN
cord-016938-pk76snuy	227	30	a	a	DT
cord-016938-pk76snuy	227	31	vacuum	vacuum	NN
cord-016938-pk76snuy	227	32	oven	oven	NN
cord-016938-pk76snuy	227	33	for	for	IN
cord-016938-pk76snuy	227	34	2	2	CD
cord-016938-pk76snuy	227	35	days	day	NNS
cord-016938-pk76snuy	227	36	.	.	.
cord-016938-pk76snuy	228	1	On	on	IN
cord-016938-pk76snuy	228	2	the	the	DT
cord-016938-pk76snuy	228	3	other	other	JJ
cord-016938-pk76snuy	228	4	side	side	NN
cord-016938-pk76snuy	228	5	,	,	,
cord-016938-pk76snuy	228	6	a	a	DT
cord-016938-pk76snuy	228	7	porous	porous	JJ
cord-016938-pk76snuy	228	8	collagen	collagen	NN
cord-016938-pk76snuy	228	9	-	-	HYPH
cord-016938-pk76snuy	228	10	hyaluronic	hyaluronic	NN
cord-016938-pk76snuy	228	11	acid	acid	NN
cord-016938-pk76snuy	228	12	(	(	-LRB-
cord-016938-pk76snuy	228	13	HA	HA	NNP
cord-016938-pk76snuy	228	14	-	-	HYPH
cord-016938-pk76snuy	228	15	Col	Col	NNP
cord-016938-pk76snuy	228	16	)	)	-RRB-
cord-016938-pk76snuy	228	17	membrane	membrane	NN
cord-016938-pk76snuy	228	18	was	be	VBD
cord-016938-pk76snuy	228	19	fabricated	fabricate	VBN
cord-016938-pk76snuy	228	20	and	and	CC
cord-016938-pk76snuy	228	21	crosslinked	crosslinke	VBN
cord-016938-pk76snuy	228	22	.	.	.
cord-016938-pk76snuy	229	1	1	1	CD
cord-016938-pk76snuy	229	2	%	%	NN
cord-016938-pk76snuy	229	3	of	of	IN
cord-016938-pk76snuy	229	4	hyaluronic	hyaluronic	NN
cord-016938-pk76snuy	229	5	acid	acid	NN
cord-016938-pk76snuy	229	6	(	(	-LRB-
cord-016938-pk76snuy	229	7	HA	HA	NNP
cord-016938-pk76snuy	229	8	)	)	-RRB-
cord-016938-pk76snuy	230	1	(	(	-LRB-
cord-016938-pk76snuy	230	2	sodium	sodium	NN
cord-016938-pk76snuy	230	3	salt	salt	NN
cord-016938-pk76snuy	230	4	,	,	,
cord-016938-pk76snuy	230	5	Mw	Mw	NNP
cord-016938-pk76snuy	230	6	=	=	SYM
cord-016938-pk76snuy	230	7	120,000	120,000	CD
cord-016938-pk76snuy	230	8	−	−	CD
cord-016938-pk76snuy	230	9	150,000	150,000	CD
cord-016938-pk76snuy	230	10	)	)	-RRB-
cord-016938-pk76snuy	230	11	as	as	IN
cord-016938-pk76snuy	230	12	an	an	DT
cord-016938-pk76snuy	230	13	aqueous	aqueous	JJ
cord-016938-pk76snuy	230	14	so-	so-	NN
cord-016938-pk76snuy	231	1	To	to	TO
cord-016938-pk76snuy	231	2	prepare	prepare	VB
cord-016938-pk76snuy	231	3	HA	HA	NNP
cord-016938-pk76snuy	231	4	-	-	HYPH
cord-016938-pk76snuy	231	5	Col	Col	NNP
cord-016938-pk76snuy	231	6	and	and	CC
cord-016938-pk76snuy	231	7	mPEG	mPEG	NNP
cord-016938-pk76snuy	231	8	-	-	HYPH
cord-016938-pk76snuy	231	9	PLGA	plga	JJ
cord-016938-pk76snuy	231	10	bi	bi	JJ
cord-016938-pk76snuy	231	11	-	-	JJ
cord-016938-pk76snuy	231	12	layered	layered	JJ
cord-016938-pk76snuy	231	13	composite	composite	JJ
cord-016938-pk76snuy	231	14	membrane	membrane	NN
cord-016938-pk76snuy	231	15	,	,	,
cord-016938-pk76snuy	231	16	chloroform	chloroform	NN
cord-016938-pk76snuy	231	17	was	be	VBD
cord-016938-pk76snuy	231	18	sprayed	spray	VBN
cord-016938-pk76snuy	231	19	on	on	IN
cord-016938-pk76snuy	231	20	the	the	DT
cord-016938-pk76snuy	231	21	surface	surface	NN
cord-016938-pk76snuy	231	22	of	of	IN
cord-016938-pk76snuy	231	23	mPEG	mPEG	NNP
cord-016938-pk76snuy	231	24	-	-	HYPH
cord-016938-pk76snuy	231	25	PLGA	PLGA	NNP
cord-016938-pk76snuy	231	26	film	film	NN
cord-016938-pk76snuy	231	27	,	,	,
cord-016938-pk76snuy	231	28	and	and	CC
cord-016938-pk76snuy	231	29	then	then	RB
cord-016938-pk76snuy	231	30	cross	cross	VB
cord-016938-pk76snuy	231	31	-	-	JJ
cord-016938-pk76snuy	231	32	linked	link	VBN
cord-016938-pk76snuy	231	33	HA	HA	NNP
cord-016938-pk76snuy	231	34	-	-	HYPH
cord-016938-pk76snuy	231	35	FN	FN	NNP
cord-016938-pk76snuy	231	36	-	-	HYPH
cord-016938-pk76snuy	231	37	Col	col	NN
cord-016938-pk76snuy	231	38	membrane	membrane	NN
cord-016938-pk76snuy	231	39	was	be	VBD
cord-016938-pk76snuy	231	40	loaded	load	VBN
cord-016938-pk76snuy	231	41	on	on	IN
cord-016938-pk76snuy	231	42	the	the	DT
cord-016938-pk76snuy	231	43	slightly	slightly	RB
cord-016938-pk76snuy	231	44	dissolved	dissolve	VBN
cord-016938-pk76snuy	231	45	surface	surface	NN
cord-016938-pk76snuy	231	46	of	of	IN
cord-016938-pk76snuy	231	47	mPEG	mpeg	NN
cord-016938-pk76snuy	231	48	-	-	HYPH
cord-016938-pk76snuy	231	49	PLGA	PLGA	NNP
cord-016938-pk76snuy	231	50	film	film	NN
cord-016938-pk76snuy	231	51	.	.	.
cord-016938-pk76snuy	232	1	In	in	IN
cord-016938-pk76snuy	232	2	vitro	vitro	FW
cord-016938-pk76snuy	232	3	adhesion	adhesion	NN
cord-016938-pk76snuy	232	4	test	test	NN
cord-016938-pk76snuy	232	5	revealed	reveal	VBD
cord-016938-pk76snuy	232	6	that	that	IN
cord-016938-pk76snuy	232	7	fibroblasts	fibroblast	NNS
cord-016938-pk76snuy	232	8	attached	attach	VBN
cord-016938-pk76snuy	232	9	better	well	RBR
cord-016938-pk76snuy	232	10	on	on	IN
cord-016938-pk76snuy	232	11	HA	HA	NNP
cord-016938-pk76snuy	232	12	-	-	HYPH
cord-016938-pk76snuy	232	13	Col	col	NN
cord-016938-pk76snuy	232	14	membrane	membrane	NN
cord-016938-pk76snuy	232	15	compared	compare	VBN
cord-016938-pk76snuy	232	16	to	to	IN
cord-016938-pk76snuy	232	17	those	those	DT
cord-016938-pk76snuy	232	18	on	on	IN
cord-016938-pk76snuy	232	19	mPEG	mPEG	NNP
cord-016938-pk76snuy	232	20	-	-	HYPH
cord-016938-pk76snuy	232	21	PLGA	PLGA	NNP
cord-016938-pk76snuy	232	22	film	film	NN
cord-016938-pk76snuy	232	23	,	,	,
cord-016938-pk76snuy	232	24	PLGA	PLGA	NNP
cord-016938-pk76snuy	232	25	film	film	NN
cord-016938-pk76snuy	232	26	or	or	CC
cord-016938-pk76snuy	232	27	oxidized	oxidize	VBN
cord-016938-pk76snuy	232	28	cellulose	cellulose	NN
cord-016938-pk76snuy	232	29	film	film	NN
cord-016938-pk76snuy	232	30	.	.	.
cord-016938-pk76snuy	233	1	mPEG	mPEG	NNP
cord-016938-pk76snuy	233	2	-	-	HYPH
cord-016938-pk76snuy	233	3	PLGA	PLGA	NNP
cord-016938-pk76snuy	233	4	film	film	NN
cord-016938-pk76snuy	233	5	had	have	VBD
cord-016938-pk76snuy	233	6	the	the	DT
cord-016938-pk76snuy	233	7	lowest	low	JJS
cord-016938-pk76snuy	233	8	cell	cell	NN
cord-016938-pk76snuy	233	9	adhesive	adhesive	NN
cord-016938-pk76snuy	233	10	property	property	NN
cord-016938-pk76snuy	233	11	.	.	.
cord-016938-pk76snuy	234	1	In	in	IN
cord-016938-pk76snuy	234	2	confocal	confocal	JJ
cord-016938-pk76snuy	234	3	microscopic	microscopic	JJ
cord-016938-pk76snuy	234	4	observation	observation	NN
cord-016938-pk76snuy	234	5	,	,	,
cord-016938-pk76snuy	234	6	the	the	DT
cord-016938-pk76snuy	234	7	actin	actin	NN
cord-016938-pk76snuy	234	8	filaments	filament	NNS
cord-016938-pk76snuy	234	9	were	be	VBD
cord-016938-pk76snuy	234	10	significantly	significantly	RB
cord-016938-pk76snuy	234	11	more	more	RBR
cord-016938-pk76snuy	234	12	polymerized	polymerize	VBN
cord-016938-pk76snuy	234	13	when	when	WRB
cord-016938-pk76snuy	234	14	50	50	CD
cord-016938-pk76snuy	234	15	or	or	CC
cord-016938-pk76snuy	234	16	100	100	CD
cord-016938-pk76snuy	234	17	μg	μg	NN
cord-016938-pk76snuy	234	18	/	/	SYM
cord-016938-pk76snuy	234	19	cm	cm	NN
cord-016938-pk76snuy	234	20	3	3	CD
cord-016938-pk76snuy	234	21	fibronectin	fibronectin	NN
cord-016938-pk76snuy	234	22	was	be	VBD
cord-016938-pk76snuy	234	23	incorporated	incorporate	VBN
cord-016938-pk76snuy	234	24	on	on	IN
cord-016938-pk76snuy	234	25	the	the	DT
cord-016938-pk76snuy	234	26	HA	HA	NNP
cord-016938-pk76snuy	234	27	-	-	HYPH
cord-016938-pk76snuy	234	28	Col	Col	NNP
cord-016938-pk76snuy	234	29	membranes	membrane	NNS
cord-016938-pk76snuy	234	30	.	.	.
cord-016938-pk76snuy	235	1	After	after	IN
cord-016938-pk76snuy	235	2	7-day	7-day	JJ
cord-016938-pk76snuy	235	3	culture	culture	NN
cord-016938-pk76snuy	235	4	,	,	,
cord-016938-pk76snuy	235	5	fibroblasts	fibroblast	NNS
cord-016938-pk76snuy	235	6	penetrated	penetrate	VBD
cord-016938-pk76snuy	235	7	throughout	throughout	IN
cord-016938-pk76snuy	235	8	the	the	DT
cord-016938-pk76snuy	235	9	HAFN	HAFN	NNP
cord-016938-pk76snuy	235	10	-	-	HYPH
cord-016938-pk76snuy	235	11	Col	Col	NNP
cord-016938-pk76snuy	235	12	network	network	NN
cord-016938-pk76snuy	235	13	and	and	CC
cord-016938-pk76snuy	235	14	the	the	DT
cord-016938-pk76snuy	235	15	cell	cell	NN
cord-016938-pk76snuy	235	16	density	density	NN
cord-016938-pk76snuy	235	17	increased	increase	VBD
cord-016938-pk76snuy	235	18	whereas	whereas	IN
cord-016938-pk76snuy	235	19	very	very	RB
cord-016938-pk76snuy	235	20	few	few	JJ
cord-016938-pk76snuy	235	21	cells	cell	NNS
cord-016938-pk76snuy	235	22	were	be	VBD
cord-016938-pk76snuy	235	23	found	find	VBN
cord-016938-pk76snuy	235	24	attached	attach	VBN
cord-016938-pk76snuy	235	25	on	on	IN
cord-016938-pk76snuy	235	26	surface	surface	NN
cord-016938-pk76snuy	235	27	of	of	IN
cord-016938-pk76snuy	235	28	the	the	DT
cord-016938-pk76snuy	235	29	mPEG	mPEG	NNP
cord-016938-pk76snuy	235	30	-	-	HYPH
cord-016938-pk76snuy	235	31	PLGA	PLGA	NNP
cord-016938-pk76snuy	235	32	film	film	NN
cord-016938-pk76snuy	235	33	.	.	.
cord-016938-pk76snuy	236	1	In	in	IN
cord-016938-pk76snuy	236	2	vivo	vivo	NN
cord-016938-pk76snuy	236	3	evaluation	evaluation	NN
cord-016938-pk76snuy	236	4	by	by	IN
cord-016938-pk76snuy	236	5	implantation	implantation	NN
cord-016938-pk76snuy	236	6	test	test	NN
cord-016938-pk76snuy	236	7	for	for	IN
cord-016938-pk76snuy	236	8	7	7	CD
cord-016938-pk76snuy	236	9	days	day	NNS
cord-016938-pk76snuy	236	10	in	in	IN
cord-016938-pk76snuy	236	11	rabbit	rabbit	NN
cord-016938-pk76snuy	236	12	's	's	POS
cord-016938-pk76snuy	236	13	peritoneal	peritoneal	NN
cord-016938-pk76snuy	236	14	wound	wound	NN
cord-016938-pk76snuy	236	15	showed	show	VBD
cord-016938-pk76snuy	236	16	that	that	IN
cord-016938-pk76snuy	236	17	the	the	DT
cord-016938-pk76snuy	236	18	composite	composite	JJ
cord-016938-pk76snuy	236	19	membrane	membrane	NN
cord-016938-pk76snuy	236	20	could	could	MD
cord-016938-pk76snuy	236	21	protect	protect	VB
cord-016938-pk76snuy	236	22	tissue	tissue	NN
cord-016938-pk76snuy	236	23	 	 	_SP
cord-016938-pk76snuy	236	24	Collagen	Collagen	NNP
cord-016938-pk76snuy	236	25	based	base	VBN
cord-016938-pk76snuy	236	26	biomaterial	biomaterial	NN
cord-016938-pk76snuy	236	27	was	be	VBD
cord-016938-pk76snuy	236	28	also	also	RB
cord-016938-pk76snuy	236	29	applied	apply	VBN
cord-016938-pk76snuy	236	30	as	as	IN
cord-016938-pk76snuy	236	31	a	a	DT
cord-016938-pk76snuy	236	32	mesenchymal	mesenchymal	JJ
cord-016938-pk76snuy	236	33	stem	stem	NN
cord-016938-pk76snuy	236	34	cell	cell	NN
cord-016938-pk76snuy	236	35	(	(	-LRB-
cord-016938-pk76snuy	236	36	MSC	MSC	NNP
cord-016938-pk76snuy	236	37	)	)	-RRB-
cord-016938-pk76snuy	236	38	delivery	delivery	NN
cord-016938-pk76snuy	236	39	vehicle	vehicle	NN
cord-016938-pk76snuy	236	40	.	.	.
cord-016938-pk76snuy	237	1	Liver	liver	NN
cord-016938-pk76snuy	237	2	hepatocyte	hepatocyte	NN
cord-016938-pk76snuy	237	3	is	be	VBZ
cord-016938-pk76snuy	237	4	a	a	DT
cord-016938-pk76snuy	237	5	representative	representative	JJ
cord-016938-pk76snuy	237	6	stable	stable	JJ
cord-016938-pk76snuy	237	7	cell	cell	NN
cord-016938-pk76snuy	237	8	that	that	WDT
cord-016938-pk76snuy	237	9	has	have	VBZ
cord-016938-pk76snuy	237	10	tremendous	tremendous	JJ
cord-016938-pk76snuy	237	11	proliferative	proliferative	JJ
cord-016938-pk76snuy	237	12	capacity	capacity	NN
cord-016938-pk76snuy	237	13	and	and	CC
cord-016938-pk76snuy	237	14	ability	ability	NN
cord-016938-pk76snuy	237	15	to	to	TO
cord-016938-pk76snuy	237	16	differentiate	differentiate	VB
cord-016938-pk76snuy	237	17	and	and	CC
cord-016938-pk76snuy	237	18	proliferate	proliferate	VB
cord-016938-pk76snuy	237	19	when	when	WRB
cord-016938-pk76snuy	237	20	injury	injury	NN
cord-016938-pk76snuy	237	21	or	or	CC
cord-016938-pk76snuy	237	22	damage	damage	NN
cord-016938-pk76snuy	237	23	occurs	occur	VBZ
cord-016938-pk76snuy	237	24	in	in	IN
cord-016938-pk76snuy	237	25	liver	liver	NN
cord-016938-pk76snuy	237	26	.	.	.
cord-016938-pk76snuy	238	1	In	in	IN
cord-016938-pk76snuy	238	2	case	case	NN
cord-016938-pk76snuy	238	3	of	of	IN
cord-016938-pk76snuy	238	4	no	no	DT
cord-016938-pk76snuy	238	5	-	-	HYPH
cord-016938-pk76snuy	238	6	proliferation	proliferation	NN
cord-016938-pk76snuy	238	7	of	of	IN
cord-016938-pk76snuy	238	8	hepatocytes	hepatocyte	NNS
cord-016938-pk76snuy	238	9	,	,	,
cord-016938-pk76snuy	238	10	oval	oval	JJ
cord-016938-pk76snuy	238	11	cells	cell	NNS
cord-016938-pk76snuy	238	12	are	be	VBP
cord-016938-pk76snuy	238	13	stimulated	stimulate	VBN
cord-016938-pk76snuy	238	14	to	to	TO
cord-016938-pk76snuy	238	15	divide	divide	VB
cord-016938-pk76snuy	238	16	and	and	CC
cord-016938-pk76snuy	238	17	eventually	eventually	RB
cord-016938-pk76snuy	238	18	differentiate	differentiate	VB
cord-016938-pk76snuy	238	19	into	into	IN
cord-016938-pk76snuy	238	20	mature	mature	JJ
cord-016938-pk76snuy	238	21	hepatocytes	hepatocyte	NNS
cord-016938-pk76snuy	238	22	;	;	:
cord-016938-pk76snuy	238	23	therefore	therefore	RB
cord-016938-pk76snuy	238	24	,	,	,
cord-016938-pk76snuy	238	25	an	an	DT
cord-016938-pk76snuy	238	26	oval	oval	JJ
cord-016938-pk76snuy	238	27	cell	cell	NN
cord-016938-pk76snuy	238	28	is	be	VBZ
cord-016938-pk76snuy	238	29	regarded	regard	VBN
cord-016938-pk76snuy	238	30	as	as	IN
cord-016938-pk76snuy	238	31	a	a	DT
cord-016938-pk76snuy	238	32	compensatory	compensatory	JJ
cord-016938-pk76snuy	238	33	cell	cell	NN
cord-016938-pk76snuy	238	34	in	in	IN
cord-016938-pk76snuy	238	35	liver	liver	NN
cord-016938-pk76snuy	238	36	injury	injury	NN
cord-016938-pk76snuy	238	37	,	,	,
cord-016938-pk76snuy	238	38	and	and	CC
cord-016938-pk76snuy	238	39	has	have	VBZ
cord-016938-pk76snuy	238	40	been	be	VBN
cord-016938-pk76snuy	238	41	concerned	concern	VBN
cord-016938-pk76snuy	238	42	to	to	TO
cord-016938-pk76snuy	238	43	be	be	VB
cord-016938-pk76snuy	238	44	equivalent	equivalent	JJ
cord-016938-pk76snuy	238	45	to	to	IN
cord-016938-pk76snuy	238	46	liver	liver	NN
cord-016938-pk76snuy	238	47	stem	stem	NN
cord-016938-pk76snuy	238	48	/	/	SYM
cord-016938-pk76snuy	238	49	progenitor	progenitor	NN
cord-016938-pk76snuy	238	50	cells	cell	NNS
cord-016938-pk76snuy	238	51	.	.	.
cord-016938-pk76snuy	239	1	Oval	oval	JJ
cord-016938-pk76snuy	239	2	cell	cell	NN
cord-016938-pk76snuy	239	3	is	be	VBZ
cord-016938-pk76snuy	239	4	oriented	orient	VBN
cord-016938-pk76snuy	239	5	from	from	IN
cord-016938-pk76snuy	239	6	bone	bone	NN
cord-016938-pk76snuy	239	7	marrow	marrow	NN
cord-016938-pk76snuy	239	8	mesenchymal	mesenchymal	JJ
cord-016938-pk76snuy	239	9	cell	cell	NN
cord-016938-pk76snuy	239	10	,	,	,
cord-016938-pk76snuy	239	11	and	and	CC
cord-016938-pk76snuy	239	12	is	be	VBZ
cord-016938-pk76snuy	239	13	a	a	DT
cord-016938-pk76snuy	239	14	facultative	facultative	JJ
cord-016938-pk76snuy	239	15	bipotential	bipotential	NN
cord-016938-pk76snuy	239	16	precursor	precursor	NN
cord-016938-pk76snuy	239	17	cell	cell	NN
cord-016938-pk76snuy	239	18	that	that	WDT
cord-016938-pk76snuy	239	19	differentiates	differentiate	VBZ
cord-016938-pk76snuy	239	20	into	into	IN
cord-016938-pk76snuy	239	21	hepatocytes	hepatocyte	NNS
cord-016938-pk76snuy	239	22	or	or	CC
cord-016938-pk76snuy	239	23	bile	bile	NN
cord-016938-pk76snuy	239	24	duct	duct	NN
cord-016938-pk76snuy	239	25	cells	cell	NNS
cord-016938-pk76snuy	239	26	.	.	.
cord-016938-pk76snuy	240	1	Human	human	JJ
cord-016938-pk76snuy	240	2	MSCs	msc	NNS
cord-016938-pk76snuy	240	3	harvested	harvest	VBN
cord-016938-pk76snuy	240	4	from	from	IN
cord-016938-pk76snuy	240	5	tibial	tibial	JJ
cord-016938-pk76snuy	240	6	bone	bone	NN
cord-016938-pk76snuy	240	7	marrow	marrow	NN
cord-016938-pk76snuy	240	8	and	and	CC
cord-016938-pk76snuy	240	9	co	co	JJ
cord-016938-pk76snuy	240	10	-	-	JJ
cord-016938-pk76snuy	240	11	cultured	cultured	JJ
cord-016938-pk76snuy	240	12	with	with	IN
cord-016938-pk76snuy	240	13	hepatocytes	hepatocyte	NNS
cord-016938-pk76snuy	240	14	for	for	IN
cord-016938-pk76snuy	240	15	3	3	CD
cord-016938-pk76snuy	240	16	days	day	NNS
cord-016938-pk76snuy	240	17	in	in	IN
cord-016938-pk76snuy	240	18	medium	medium	NN
cord-016938-pk76snuy	240	19	with	with	IN
cord-016938-pk76snuy	240	20	additive	additive	NN
cord-016938-pk76snuy	240	21	hepatocyte	hepatocyte	NN
cord-016938-pk76snuy	240	22	growth	growth	NN
cord-016938-pk76snuy	240	23	factor	factor	NN
cord-016938-pk76snuy	240	24	(	(	-LRB-
cord-016938-pk76snuy	240	25	HGF	hgf	NN
cord-016938-pk76snuy	240	26	)	)	-RRB-
cord-016938-pk76snuy	240	27	produced	produce	VBD
cord-016938-pk76snuy	240	28	a	a	DT
cord-016938-pk76snuy	240	29	confluent	confluent	JJ
cord-016938-pk76snuy	240	30	mixture	mixture	NN
cord-016938-pk76snuy	240	31	of	of	IN
cord-016938-pk76snuy	240	32	undifferentiated	undifferentiated	JJ
cord-016938-pk76snuy	240	33	MSCs	msc	NNS
cord-016938-pk76snuy	240	34	and	and	CC
cord-016938-pk76snuy	240	35	oval	oval	JJ
cord-016938-pk76snuy	240	36	cells	cell	NNS
cord-016938-pk76snuy	240	37	.	.	.
cord-016938-pk76snuy	241	1	To	to	TO
cord-016938-pk76snuy	241	2	purify	purify	VB
cord-016938-pk76snuy	241	3	the	the	DT
cord-016938-pk76snuy	241	4	oval	oval	JJ
cord-016938-pk76snuy	241	5	cells	cell	NNS
cord-016938-pk76snuy	241	6	from	from	IN
cord-016938-pk76snuy	241	7	nonparenchymal	nonparenchymal	NNP
cord-016938-pk76snuy	241	8	cells	cell	NNS
cord-016938-pk76snuy	241	9	,	,	,
cord-016938-pk76snuy	241	10	cell	cell	NN
cord-016938-pk76snuy	241	11	cloning	cloning	NN
cord-016938-pk76snuy	241	12	method	method	NN
cord-016938-pk76snuy	241	13	was	be	VBD
cord-016938-pk76snuy	241	14	applied	apply	VBN
cord-016938-pk76snuy	241	15	.	.	.
cord-016938-pk76snuy	242	1	Characterization	characterization	NN
cord-016938-pk76snuy	242	2	of	of	IN
cord-016938-pk76snuy	242	3	oval	oval	JJ
cord-016938-pk76snuy	242	4	cells	cell	NNS
cord-016938-pk76snuy	242	5	was	be	VBD
cord-016938-pk76snuy	242	6	performed	perform	VBN
cord-016938-pk76snuy	242	7	by	by	IN
cord-016938-pk76snuy	242	8	a	a	DT
cord-016938-pk76snuy	242	9	double	double	JJ
cord-016938-pk76snuy	242	10	immuno-	immuno-	NN
cord-016938-pk76snuy	242	11	Observed	observe	VBN
cord-016938-pk76snuy	242	12	fiblasts	fiblast	NNS
cord-016938-pk76snuy	242	13	on	on	IN
cord-016938-pk76snuy	242	14	the	the	DT
cord-016938-pk76snuy	242	15	PEG	PEG	NNP
cord-016938-pk76snuy	242	16	-	-	HYPH
cord-016938-pk76snuy	242	17	PLGA	PLGA	NNP
cord-016938-pk76snuy	242	18	surface	surface	NN
cord-016938-pk76snuy	242	19	were	be	VBD
cord-016938-pk76snuy	242	20	significantly	significantly	RB
cord-016938-pk76snuy	242	21	fewer	few	JJR
cord-016938-pk76snuy	242	22	than	than	IN
cord-016938-pk76snuy	242	23	on	on	IN
cord-016938-pk76snuy	242	24	the	the	DT
cord-016938-pk76snuy	242	25	PLGA	PLGA	NNP
cord-016938-pk76snuy	242	26	membrane	membrane	NN
cord-016938-pk76snuy	242	27	surface	surface	NN
cord-016938-pk76snuy	242	28	.	.	.
cord-016938-pk76snuy	243	1	Collagen	Collagen	NNP
cord-016938-pk76snuy	243	2	-	-	HYPH
cord-016938-pk76snuy	243	3	HA	HA	NNP
cord-016938-pk76snuy	243	4	membrane	membrane	NN
cord-016938-pk76snuy	243	5	demonstrated	demonstrate	VBD
cord-016938-pk76snuy	243	6	high	high	JJ
cord-016938-pk76snuy	243	7	affinity	affinity	NN
cord-016938-pk76snuy	243	8	to	to	IN
cord-016938-pk76snuy	243	9	cell	cell	NN
cord-016938-pk76snuy	243	10	attachment	attachment	NN
cord-016938-pk76snuy	243	11	fluorescence	fluorescence	NN
cord-016938-pk76snuy	243	12	method	method	NN
cord-016938-pk76snuy	243	13	using	use	VBG
cord-016938-pk76snuy	243	14	alpha	alpha	NN
cord-016938-pk76snuy	243	15	-	-	HYPH
cord-016938-pk76snuy	243	16	fetoprotein	fetoprotein	NNP
cord-016938-pk76snuy	243	17	(	(	-LRB-
cord-016938-pk76snuy	243	18	AFP	AFP	NNP
cord-016938-pk76snuy	243	19	)	)	-RRB-
cord-016938-pk76snuy	243	20	and	and	CC
cord-016938-pk76snuy	243	21	cytokeratin-19	cytokeratin-19	CD
cord-016938-pk76snuy	243	22	monoclonal	monoclonal	JJ
cord-016938-pk76snuy	243	23	antibody	antibody	NN
cord-016938-pk76snuy	243	24	expecting	expect	VBG
cord-016938-pk76snuy	243	25	co	co	NN
cord-016938-pk76snuy	243	26	-	-	NN
cord-016938-pk76snuy	243	27	expression	expression	NN
cord-016938-pk76snuy	243	28	.	.	.
cord-016938-pk76snuy	244	1	Isolated	isolate	VBN
cord-016938-pk76snuy	244	2	human	human	JJ
cord-016938-pk76snuy	244	3	MSCs	msc	NNS
cord-016938-pk76snuy	244	4	oriented	orient	VBN
cord-016938-pk76snuy	244	5	oval	oval	JJ
cord-016938-pk76snuy	244	6	cells	cell	NNS
cord-016938-pk76snuy	244	7	were	be	VBD
cord-016938-pk76snuy	244	8	seeded	seed	VBN
cord-016938-pk76snuy	244	9	on	on	IN
cord-016938-pk76snuy	244	10	an	an	DT
cord-016938-pk76snuy	244	11	EDC	EDC	NNP
cord-016938-pk76snuy	244	12	crosslinked	crosslinke	VBD
cord-016938-pk76snuy	244	13	porous	porous	JJ
cord-016938-pk76snuy	244	14	type	type	NN
cord-016938-pk76snuy	244	15	I	-PRON-	PRP
cord-016938-pk76snuy	244	16	atelocollagen	atelocollagen	VBP
cord-016938-pk76snuy	244	17	matrix	matrix	NN
cord-016938-pk76snuy	244	18	,	,	,
cord-016938-pk76snuy	244	19	and	and	CC
cord-016938-pk76snuy	244	20	cultured	culture	VBN
cord-016938-pk76snuy	244	21	in	in	IN
cord-016938-pk76snuy	244	22	medium	medium	JJ
cord-016938-pk76snuy	244	23	containing	contain	VBG
cord-016938-pk76snuy	244	24	insulin	insulin	NN
cord-016938-pk76snuy	244	25	,	,	,
cord-016938-pk76snuy	244	26	dexamethasone	dexamethasone	NN
cord-016938-pk76snuy	244	27	,	,	,
cord-016938-pk76snuy	244	28	and	and	CC
cord-016938-pk76snuy	244	29	hydrocortisone	hydrocortisone	NN
cord-016938-pk76snuy	244	30	as	as	IN
cord-016938-pk76snuy	244	31	the	the	DT
cord-016938-pk76snuy	244	32	hormone	hormone	NN
cord-016938-pk76snuy	244	33	stimulators	stimulator	NNS
cord-016938-pk76snuy	244	34	and	and	CC
cord-016938-pk76snuy	244	35	additive	additive	NN
cord-016938-pk76snuy	244	36	cytokines	cytokine	NNS
cord-016938-pk76snuy	244	37	of	of	IN
cord-016938-pk76snuy	244	38	HGF	hgf	NN
cord-016938-pk76snuy	244	39	and	and	CC
cord-016938-pk76snuy	244	40	epidermal	epidermal	JJ
cord-016938-pk76snuy	244	41	growth	growth	NN
cord-016938-pk76snuy	244	42	factor	factor	NN
cord-016938-pk76snuy	244	43	(	(	-LRB-
cord-016938-pk76snuy	244	44	EGF	EGF	NNP
cord-016938-pk76snuy	244	45	)	)	-RRB-
cord-016938-pk76snuy	244	46	.	.	.
cord-016938-pk76snuy	245	1	For	for	IN
cord-016938-pk76snuy	245	2	Co.	Co.	NNP
cord-016938-pk76snuy	245	3	)	)	-RRB-
cord-016938-pk76snuy	245	4	is	be	VBZ
cord-016938-pk76snuy	245	5	a	a	DT
cord-016938-pk76snuy	245	6	commercially	commercially	RB
cord-016938-pk76snuy	245	7	available	available	JJ
cord-016938-pk76snuy	245	8	anti	anti	JJ
cord-016938-pk76snuy	245	9	-	-	JJ
cord-016938-pk76snuy	245	10	adhesive	adhesive	JJ
cord-016938-pk76snuy	245	11	membrane	membrane	NN
cord-016938-pk76snuy	245	12	made	make	VBN
cord-016938-pk76snuy	245	13	by	by	IN
cord-016938-pk76snuy	245	14	oxidized	oxidize	VBN
cord-016938-pk76snuy	245	15	cellulose	cellulose	NN
cord-016938-pk76snuy	245	16	3	3	CD
cord-016938-pk76snuy	245	17	weeks	week	NNS
cord-016938-pk76snuy	245	18	,	,	,
cord-016938-pk76snuy	245	19	albumin	albumin	NN
cord-016938-pk76snuy	245	20	secretion	secretion	NN
cord-016938-pk76snuy	245	21	and	and	CC
cord-016938-pk76snuy	245	22	urea	urea	NN
cord-016938-pk76snuy	245	23	detoxification	detoxification	NN
cord-016938-pk76snuy	245	24	rate	rate	NN
cord-016938-pk76snuy	245	25	continuously	continuously	RB
cord-016938-pk76snuy	245	26	increased	increase	VBD
cord-016938-pk76snuy	245	27	either	either	CC
cord-016938-pk76snuy	245	28	in	in	IN
cord-016938-pk76snuy	245	29	the	the	DT
cord-016938-pk76snuy	245	30	hormone	hormone	NN
cord-016938-pk76snuy	245	31	additive	additive	NN
cord-016938-pk76snuy	245	32	or	or	CC
cord-016938-pk76snuy	245	33	the	the	DT
cord-016938-pk76snuy	245	34	cytokine	cytokine	NN
cord-016938-pk76snuy	245	35	additive	additive	NN
cord-016938-pk76snuy	245	36	groups	group	NNS
cord-016938-pk76snuy	245	37	,	,	,
cord-016938-pk76snuy	245	38	and	and	CC
cord-016938-pk76snuy	245	39	this	this	DT
cord-016938-pk76snuy	245	40	was	be	VBD
cord-016938-pk76snuy	245	41	directive	directive	NN
cord-016938-pk76snuy	245	42	knowledge	knowledge	NN
cord-016938-pk76snuy	245	43	that	that	DT
cord-016938-pk76snuy	245	44	avoidance	avoidance	NN
cord-016938-pk76snuy	245	45	of	of	IN
cord-016938-pk76snuy	245	46	using	use	VBG
cord-016938-pk76snuy	245	47	growth	growth	NN
cord-016938-pk76snuy	245	48	factors	factor	NNS
cord-016938-pk76snuy	245	49	in	in	IN
cord-016938-pk76snuy	245	50	committing	commit	VBG
cord-016938-pk76snuy	245	51	MSC	MSC	NNP
cord-016938-pk76snuy	245	52	-	-	HYPH
cord-016938-pk76snuy	245	53	oriented	orient	VBN
cord-016938-pk76snuy	245	54	oval	oval	JJ
cord-016938-pk76snuy	245	55	cell	cell	NN
cord-016938-pk76snuy	245	56	toward	toward	IN
cord-016938-pk76snuy	245	57	hepatocyte	hepatocyte	NN
cord-016938-pk76snuy	245	58	can	can	MD
cord-016938-pk76snuy	245	59	escape	escape	VB
cord-016938-pk76snuy	245	60	from	from	IN
cord-016938-pk76snuy	245	61	risky	risky	JJ
cord-016938-pk76snuy	245	62	induction	induction	NN
cord-016938-pk76snuy	245	63	to	to	IN
cord-016938-pk76snuy	245	64	liver	liver	NN
cord-016938-pk76snuy	245	65	cancer	cancer	NN
cord-016938-pk76snuy	245	66	.	.	.
cord-016938-pk76snuy	246	1	The	the	DT
cord-016938-pk76snuy	246	2	collagen	collagen	NN
cord-016938-pk76snuy	246	3	scaffold	scaffold	NN
cord-016938-pk76snuy	246	4	was	be	VBD
cord-016938-pk76snuy	246	5	able	able	JJ
cord-016938-pk76snuy	246	6	to	to	TO
cord-016938-pk76snuy	246	7	foster	foster	VB
cord-016938-pk76snuy	246	8	long	long	JJ
cord-016938-pk76snuy	246	9	-	-	HYPH
cord-016938-pk76snuy	246	10	term	term	NN
cord-016938-pk76snuy	246	11	viability	viability	NN
cord-016938-pk76snuy	246	12	and	and	CC
cord-016938-pk76snuy	246	13	protection	protection	NN
cord-016938-pk76snuy	246	14	of	of	IN
cord-016938-pk76snuy	246	15	the	the	DT
cord-016938-pk76snuy	246	16	cells	cell	NNS
cord-016938-pk76snuy	246	17	,	,	,
cord-016938-pk76snuy	246	18	and	and	CC
cord-016938-pk76snuy	246	19	this	this	DT
cord-016938-pk76snuy	246	20	3-dimensional	3-dimensional	JJ
cord-016938-pk76snuy	246	21	culture	culture	NN
cord-016938-pk76snuy	246	22	of	of	IN
cord-016938-pk76snuy	246	23	oval	oval	JJ
cord-016938-pk76snuy	246	24	cells	cell	NNS
cord-016938-pk76snuy	246	25	is	be	VBZ
cord-016938-pk76snuy	246	26	considerable	considerable	JJ
cord-016938-pk76snuy	246	27	for	for	IN
cord-016938-pk76snuy	246	28	designing	design	VBG
cord-016938-pk76snuy	246	29	a	a	DT
cord-016938-pk76snuy	246	30	cell	cell	NN
cord-016938-pk76snuy	246	31	-	-	HYPH
cord-016938-pk76snuy	246	32	delivering	deliver	VBG
cord-016938-pk76snuy	246	33	tool	tool	NN
cord-016938-pk76snuy	246	34	for	for	IN
cord-016938-pk76snuy	246	35	hepatic	hepatic	JJ
cord-016938-pk76snuy	246	36	disease	disease	NN
cord-016938-pk76snuy	246	37	[	[	-LRB-
cord-016938-pk76snuy	246	38	33	33	CD
cord-016938-pk76snuy	246	39	]	]	-RRB-
cord-016938-pk76snuy	246	40	(	(	-LRB-
cord-016938-pk76snuy	246	41	Figs	fig	NNS
cord-016938-pk76snuy	246	42	.	.	.
cord-016938-pk76snuy	246	43	8.33	8.33	CD
cord-016938-pk76snuy	246	44	-	-	CD
cord-016938-pk76snuy	246	45	8.38	8.38	CD
cord-016938-pk76snuy	246	46	)	)	-RRB-
cord-016938-pk76snuy	246	47	.	.	.
cord-016938-pk76snuy	247	1	Asymmetric	asymmetric	JJ
cord-016938-pk76snuy	247	2	collagen	collagen	NN
cord-016938-pk76snuy	247	3	-	-	HYPH
cord-016938-pk76snuy	247	4	fibronectin	fibronectin	NN
cord-016938-pk76snuy	247	5	grafted	graft	VBN
cord-016938-pk76snuy	248	1	PEG	PEG	NNP
cord-016938-pk76snuy	248	2	-	-	HYPH
cord-016938-pk76snuy	248	3	PLGA	PLGA	NNP
cord-016938-pk76snuy	248	4	copolymer	copolymer	NN
cord-016938-pk76snuy	248	5	membrane	membrane	NN
cord-016938-pk76snuy	248	6	was	be	VBD
cord-016938-pk76snuy	248	7	appeared	appear	VBN
cord-016938-pk76snuy	248	8	to	to	TO
cord-016938-pk76snuy	248	9	successfully	successfully	RB
cord-016938-pk76snuy	248	10	reduce	reduce	VB
cord-016938-pk76snuy	248	11	the	the	DT
cord-016938-pk76snuy	248	12	incidence	incidence	NN
cord-016938-pk76snuy	248	13	of	of	IN
cord-016938-pk76snuy	248	14	postoperative	postoperative	JJ
cord-016938-pk76snuy	248	15	adhesion	adhesion	NN
cord-016938-pk76snuy	248	16	formation	formation	NN
cord-016938-pk76snuy	248	17	 	 	_SP
cord-016938-pk76snuy	248	18	Although	although	IN
cord-016938-pk76snuy	248	19	collagen	collagen	NN
cord-016938-pk76snuy	248	20	is	be	VBZ
cord-016938-pk76snuy	248	21	a	a	DT
cord-016938-pk76snuy	248	22	favorable	favorable	JJ
cord-016938-pk76snuy	248	23	biomaterial	biomaterial	NN
cord-016938-pk76snuy	248	24	to	to	TO
cord-016938-pk76snuy	248	25	be	be	VB
cord-016938-pk76snuy	248	26	employed	employ	VBN
cord-016938-pk76snuy	248	27	in	in	IN
cord-016938-pk76snuy	248	28	a	a	DT
cord-016938-pk76snuy	248	29	wide	wide	JJ
cord-016938-pk76snuy	248	30	range	range	NN
cord-016938-pk76snuy	248	31	of	of	IN
cord-016938-pk76snuy	248	32	fabrication	fabrication	NN
cord-016938-pk76snuy	248	33	procedures	procedure	NNS
cord-016938-pk76snuy	248	34	with	with	IN
cord-016938-pk76snuy	248	35	cells	cell	NNS
cord-016938-pk76snuy	248	36	,	,	,
cord-016938-pk76snuy	248	37	there	there	EX
cord-016938-pk76snuy	248	38	is	be	VBZ
cord-016938-pk76snuy	248	39	no	no	DT
cord-016938-pk76snuy	248	40	established	establish	VBN
cord-016938-pk76snuy	248	41	tool	tool	NN
cord-016938-pk76snuy	248	42	to	to	TO
cord-016938-pk76snuy	248	43	isolate	isolate	VB
cord-016938-pk76snuy	248	44	and	and	CC
cord-016938-pk76snuy	248	45	produce	produce	VB
cord-016938-pk76snuy	248	46	absolute	absolute	JJ
cord-016938-pk76snuy	248	47	atelocollagen	atelocollagen	NN
cord-016938-pk76snuy	248	48	,	,	,
cord-016938-pk76snuy	248	49	the	the	DT
cord-016938-pk76snuy	248	50	immune	immune	NN
cord-016938-pk76snuy	248	51	-	-	HYPH
cord-016938-pk76snuy	248	52	free	free	JJ
cord-016938-pk76snuy	248	53	substitute	substitute	NN
cord-016938-pk76snuy	248	54	,	,	,
cord-016938-pk76snuy	248	55	at	at	IN
cord-016938-pk76snuy	248	56	present	present	NN
cord-016938-pk76snuy	248	57	.	.	.
cord-016938-pk76snuy	249	1	Even	even	RB
cord-016938-pk76snuy	249	2	a	a	DT
cord-016938-pk76snuy	249	3	single	single	JJ
cord-016938-pk76snuy	249	4	remaining	remain	VBG
cord-016938-pk76snuy	249	5	collagen	collagen	NN
cord-016938-pk76snuy	249	6	dimer	dimer	NN
cord-016938-pk76snuy	249	7	or	or	CC
cord-016938-pk76snuy	249	8	trimer	trimer	NN
cord-016938-pk76snuy	249	9	may	may	MD
cord-016938-pk76snuy	249	10	cause	cause	VB
cord-016938-pk76snuy	249	11	immune	immune	JJ
cord-016938-pk76snuy	249	12	reactions	reaction	NNS
cord-016938-pk76snuy	249	13	in	in	IN
cord-016938-pk76snuy	249	14	future	future	NN
cord-016938-pk76snuy	249	15	.	.	.
cord-016938-pk76snuy	250	1	The	the	DT
cord-016938-pk76snuy	250	2	resource	resource	NN
cord-016938-pk76snuy	250	3	of	of	IN
cord-016938-pk76snuy	250	4	collagen	collagen	NN
cord-016938-pk76snuy	250	5	,	,	,
cord-016938-pk76snuy	250	6	especially	especially	RB
cord-016938-pk76snuy	250	7	for	for	IN
cord-016938-pk76snuy	250	8	clinical	clinical	JJ
cord-016938-pk76snuy	250	9	applications	application	NNS
cord-016938-pk76snuy	250	10	is	be	VBZ
cord-016938-pk76snuy	250	11	also	also	RB
cord-016938-pk76snuy	250	12	important	important	JJ
cord-016938-pk76snuy	250	13	,	,	,
cord-016938-pk76snuy	250	14	because	because	IN
cord-016938-pk76snuy	250	15	unknown	unknown	JJ
cord-016938-pk76snuy	250	16	viruses	virus	NNS
cord-016938-pk76snuy	250	17	that	that	WDT
cord-016938-pk76snuy	250	18	produce	produce	VBP
cord-016938-pk76snuy	250	19	future	future	JJ
cord-016938-pk76snuy	250	20	unpredictable	unpredictable	JJ
cord-016938-pk76snuy	250	21	diseases	disease	NNS
cord-016938-pk76snuy	250	22	from	from	IN
cord-016938-pk76snuy	250	23	xenogeneic	xenogeneic	NNP
cord-016938-pk76snuy	250	24	extracellular	extracellular	JJ
cord-016938-pk76snuy	250	25	matrix	matrix	NN
cord-016938-pk76snuy	250	26	may	may	MD
cord-016938-pk76snuy	250	27	exist	exist	VB
cord-016938-pk76snuy	250	28	.	.	.
cord-016938-pk76snuy	251	1	If	if	IN
cord-016938-pk76snuy	251	2	single	single	JJ
cord-016938-pk76snuy	251	3	-	-	HYPH
cord-016938-pk76snuy	251	4	cell	cell	NN
cord-016938-pk76snuy	251	5	encapsulation	encapsulation	NN
cord-016938-pk76snuy	251	6	by	by	IN
cord-016938-pk76snuy	251	7	collagen	collagen	NN
cord-016938-pk76snuy	251	8	containing	contain	VBG
cord-016938-pk76snuy	251	9	signal	signal	NN
cord-016938-pk76snuy	251	10	transduction	transduction	NN
cord-016938-pk76snuy	251	11	agents	agent	NNS
cord-016938-pk76snuy	251	12	and	and	CC
cord-016938-pk76snuy	251	13	ligands	ligand	NNS
cord-016938-pk76snuy	251	14	attracting	attract	VBG
cord-016938-pk76snuy	251	15	specific	specific	JJ
cord-016938-pk76snuy	251	16	cell	cell	NN
cord-016938-pk76snuy	251	17	adhesive	adhesive	NN
cord-016938-pk76snuy	251	18	receptors	receptor	NNS
cord-016938-pk76snuy	251	19	is	be	VBZ
cord-016938-pk76snuy	251	20	systemized	systemize	VBN
cord-016938-pk76snuy	251	21	,	,	,
cord-016938-pk76snuy	251	22	commitment	commitment	NN
cord-016938-pk76snuy	251	23	of	of	IN
cord-016938-pk76snuy	251	24	stem	stem	NN
cord-016938-pk76snuy	251	25	cell	cell	NN
cord-016938-pk76snuy	251	26	differentiation	differentiation	NN
cord-016938-pk76snuy	251	27	and	and	CC
cord-016938-pk76snuy	251	28	proliferation	proliferation	NN
cord-016938-pk76snuy	251	29	toward	toward	IN
cord-016938-pk76snuy	251	30	the	the	DT
cord-016938-pk76snuy	251	31	designated	designate	VBN
cord-016938-pk76snuy	251	32	target	target	NN
cord-016938-pk76snuy	251	33	tissue	tissue	NN
cord-016938-pk76snuy	251	34	will	will	MD
cord-016938-pk76snuy	251	35	be	be	VB
cord-016938-pk76snuy	251	36	achieved	achieve	VBN
cord-016938-pk76snuy	251	37	,	,	,
cord-016938-pk76snuy	251	38	and	and	CC
cord-016938-pk76snuy	251	39	this	this	DT
cord-016938-pk76snuy	251	40	may	may	MD
cord-016938-pk76snuy	251	41	contribute	contribute	VB
cord-016938-pk76snuy	251	42	to	to	IN
cord-016938-pk76snuy	251	43	the	the	DT
cord-016938-pk76snuy	251	44	future	future	JJ
cord-016938-pk76snuy	251	45	progress	progress	NN
cord-016938-pk76snuy	251	46	of	of	IN
cord-016938-pk76snuy	251	47	stem	stem	NN
cord-016938-pk76snuy	251	48	cell	cell	NN
cord-016938-pk76snuy	251	49	-	-	HYPH
cord-016938-pk76snuy	251	50	based	base	VBN
cord-016938-pk76snuy	251	51	implant	implant	NN
cord-016938-pk76snuy	251	52	.	.	.
cord-016938-pk76snuy	251	53	 	 	_SP
cord-016938-pk76snuy	252	1	Tissue	tissue	NN
cord-016938-pk76snuy	252	2	Restoration	restoration	NN
cord-016938-pk76snuy	252	3	Fundamental	fundamental	JJ
cord-016938-pk76snuy	252	4	Concepts	Concepts	NNPS
cord-016938-pk76snuy	252	5	for	for	IN
cord-016938-pk76snuy	252	6	Tissue	Tissue	NNP
cord-016938-pk76snuy	252	7	Engineering	Engineering	NNP
cord-016938-pk76snuy	252	8	Biocompatibility	Biocompatibility	NNP
cord-016938-pk76snuy	252	9	assessment	assessment	NN
cord-016938-pk76snuy	252	10	of	of	IN
cord-016938-pk76snuy	252	11	medical	medical	JJ
cord-016938-pk76snuy	252	12	devices	device	NNS
cord-016938-pk76snuy	252	13	and	and	CC
cord-016938-pk76snuy	252	14	materials	material	NNS
cord-016938-pk76snuy	253	1	Extracellular	Extracellular	NNP
cord-016938-pk76snuy	253	2	Matrix	Matrix	NNP
cord-016938-pk76snuy	253	3	Components	Components	NNP
cord-016938-pk76snuy	253	4	Anti	Anti	NNP
cord-016938-pk76snuy	253	5	-	-	JJ
cord-016938-pk76snuy	253	6	infection	infection	NN
cord-016938-pk76snuy	253	7	Treatment	treatment	NN
cord-016938-pk76snuy	253	8	of	of	IN
cord-016938-pk76snuy	253	9	a	a	DT
cord-016938-pk76snuy	253	10	Transcutaneous	transcutaneous	JJ
cord-016938-pk76snuy	253	11	Device	device	NN
cord-016938-pk76snuy	253	12	by	by	IN
cord-016938-pk76snuy	253	13	a	a	DT
cord-016938-pk76snuy	253	14	Collagen	Collagen	NNP
cord-016938-pk76snuy	253	15	-	-	HYPH
cord-016938-pk76snuy	253	16	Rifampicine	Rifampicine	NNP
cord-016938-pk76snuy	253	17	Composite	Composite	NNP
cord-016938-pk76snuy	253	18	Treatment	Treatment	NNP
cord-016938-pk76snuy	253	19	of	of	IN
cord-016938-pk76snuy	253	20	Collagen	Collagen	NNP
cord-016938-pk76snuy	253	21	for	for	IN
cord-016938-pk76snuy	253	22	Tissue	tissue	NN
cord-016938-pk76snuy	253	23	Regenerative	Regenerative	NNP
cord-016938-pk76snuy	253	24	Scaffold	Scaffold	NNP
cord-016938-pk76snuy	253	25	Reaction	reaction	NN
cord-016938-pk76snuy	253	26	Monitoring	Monitoring	NNP
cord-016938-pk76snuy	253	27	of	of	IN
cord-016938-pk76snuy	253	28	Succinylation	Succinylation	NNP
cord-016938-pk76snuy	253	29	of	of	IN
cord-016938-pk76snuy	253	30	Collagen	Collagen	NNP
cord-016938-pk76snuy	253	31	in	in	IN
cord-016938-pk76snuy	253	32	Matrix	Matrix	NNP
cord-016938-pk76snuy	253	33	-	-	HYPH
cord-016938-pk76snuy	253	34	Assisted	Assisted	NNP
cord-016938-pk76snuy	253	35	Desorption	Desorption	NNP
cord-016938-pk76snuy	253	36	/	/	SYM
cord-016938-pk76snuy	253	37	Ionization	Ionization	NNP
cord-016938-pk76snuy	253	38	Mass	Mass	NNP
cord-016938-pk76snuy	253	39	Spectrometry	Spectrometry	NNP
cord-016938-pk76snuy	253	40	Characterization	characterization	NN
cord-016938-pk76snuy	253	41	of	of	IN
cord-016938-pk76snuy	253	42	UVirradiated	UVirradiated	NNP
cord-016938-pk76snuy	253	43	Dense	Dense	NNP
cord-016938-pk76snuy	253	44	/	/	SYM
cord-016938-pk76snuy	253	45	Porous	Porous	NNP
cord-016938-pk76snuy	253	46	Collagen	Collagen	NNP
cord-016938-pk76snuy	253	47	Membranes	membrane	NNS
cord-016938-pk76snuy	253	48	:	:	:
cord-016938-pk76snuy	253	49	Morphology	morphology	NN
cord-016938-pk76snuy	253	50	,	,	,
cord-016938-pk76snuy	253	51	Degradation	degradation	NN
cord-016938-pk76snuy	253	52	,	,	,
cord-016938-pk76snuy	253	53	and	and	CC
cord-016938-pk76snuy	253	54	Mechanical	Mechanical	NNP
cord-016938-pk76snuy	253	55	Properties	Properties	NNPS
cord-016938-pk76snuy	253	56	Characterization	Characterization	NNP
cord-016938-pk76snuy	253	57	of	of	IN
cord-016938-pk76snuy	253	58	Porous	Porous	NNP
cord-016938-pk76snuy	253	59	Collagen	Collagen	NNP
cord-016938-pk76snuy	253	60	/	/	SYM
cord-016938-pk76snuy	253	61	Hyaluronic	hyaluronic	NN
cord-016938-pk76snuy	253	62	Acid	acid	NN
cord-016938-pk76snuy	253	63	caffold	caffold	NN
cord-016938-pk76snuy	253	64	Modified	modify	VBN
cord-016938-pk76snuy	253	65	by	by	IN
cord-016938-pk76snuy	253	66	1-ethyl-3(3-dimethylaminopropyl)carbodiimide	1-ethyl-3(3-dimethylaminopropyl)carbodiimide	CD
cord-016938-pk76snuy	253	67	Cross	Cross	NNP
cord-016938-pk76snuy	253	68	-	-	HYPH
cord-016938-pk76snuy	253	69	linking	link	VBG
cord-016938-pk76snuy	253	70	Preparation	preparation	NN
cord-016938-pk76snuy	253	71	of	of	IN
cord-016938-pk76snuy	253	72	Collagen	Collagen	NNP
cord-016938-pk76snuy	253	73	Modified	modify	VBD
cord-016938-pk76snuy	253	74	Hyaluronan	Hyaluronan	NNP
cord-016938-pk76snuy	253	75	Microparticles	Microparticles	NNP
cord-016938-pk76snuy	253	76	as	as	IN
cord-016938-pk76snuy	253	77	Antibiotics	Antibiotics	NNPS
cord-016938-pk76snuy	253	78	Carrier	Carrier	NNP
cord-016938-pk76snuy	253	79	Behavior	Behavior	NNP
cord-016938-pk76snuy	253	80	of	of	IN
cord-016938-pk76snuy	253	81	fibroblasts	fibroblast	NNS
cord-016938-pk76snuy	253	82	on	on	IN
cord-016938-pk76snuy	253	83	a	a	DT
cord-016938-pk76snuy	253	84	porous	porous	JJ
cord-016938-pk76snuy	253	85	hyaluronic	hyaluronic	NN
cord-016938-pk76snuy	253	86	acid	acid	NN
cord-016938-pk76snuy	253	87	incorporated	incorporate	VBN
cord-016938-pk76snuy	253	88	collagen	collagen	NN
cord-016938-pk76snuy	253	89	matrix	matrix	NN
cord-016938-pk76snuy	253	90	Laminin	Laminin	NNP
cord-016938-pk76snuy	253	91	modified	modify	VBD
cord-016938-pk76snuy	253	92	infection	infection	NN
cord-016938-pk76snuy	253	93	-	-	HYPH
cord-016938-pk76snuy	253	94	preventing	prevent	VBG
cord-016938-pk76snuy	253	95	collagen	collagen	NN
cord-016938-pk76snuy	253	96	membrane	membrane	NN
cord-016938-pk76snuy	253	97	containing	contain	VBG
cord-016938-pk76snuy	253	98	silver	silver	JJ
cord-016938-pk76snuy	253	99	sulfadiazine	sulfadiazine	NNP
cord-016938-pk76snuy	253	100	-	-	HYPH
cord-016938-pk76snuy	253	101	hyaluronan	hyaluronan	NNP
cord-016938-pk76snuy	253	102	microparticles	microparticles	.
cord-016938-pk76snuy	254	1	An	an	DT
cord-016938-pk76snuy	254	2	infection	infection	NN
cord-016938-pk76snuy	254	3	-	-	HYPH
cord-016938-pk76snuy	254	4	preventing	prevent	VBG
cord-016938-pk76snuy	254	5	bilayered	bilayered	JJ
cord-016938-pk76snuy	254	6	collagen	collagen	NN
cord-016938-pk76snuy	254	7	membrane	membrane	NN
cord-016938-pk76snuy	254	8	containing	contain	VBG
cord-016938-pk76snuy	254	9	antibiotic	antibiotic	RB
cord-016938-pk76snuy	254	10	-	-	HYPH
cord-016938-pk76snuy	254	11	loaded	load	VBN
cord-016938-pk76snuy	254	12	hyaluronan	hyaluronan	NNP
cord-016938-pk76snuy	254	13	microparticles	microparticle	NNS
cord-016938-pk76snuy	254	14	:	:	:
cord-016938-pk76snuy	254	15	physical	physical	JJ
cord-016938-pk76snuy	254	16	and	and	CC
cord-016938-pk76snuy	254	17	biological	biological	JJ
cord-016938-pk76snuy	254	18	properties	property	NNS
cord-016938-pk76snuy	254	19	Biological	biological	JJ
cord-016938-pk76snuy	254	20	characterization	characterization	NN
cord-016938-pk76snuy	254	21	of	of	IN
cord-016938-pk76snuy	254	22	EDC	EDC	NNP
cord-016938-pk76snuy	254	23	-	-	HYPH
cord-016938-pk76snuy	254	24	crosslinked	crosslinke	VBN
cord-016938-pk76snuy	254	25	collagen	collagen	NN
cord-016938-pk76snuy	254	26	-	-	HYPH
cord-016938-pk76snuy	254	27	hyaluronic	hyaluronic	NN
cord-016938-pk76snuy	254	28	acid	acid	NN
cord-016938-pk76snuy	254	29	matrix	matrix	NN
cord-016938-pk76snuy	254	30	in	in	IN
cord-016938-pk76snuy	254	31	dermal	dermal	JJ
cord-016938-pk76snuy	254	32	tissue	tissue	NN
cord-016938-pk76snuy	254	33	restoration	restoration	NN
cord-016938-pk76snuy	254	34	Evaluation	evaluation	NN
cord-016938-pk76snuy	254	35	of	of	IN
cord-016938-pk76snuy	254	36	antibiotic	antibiotic	NN
cord-016938-pk76snuy	254	37	-	-	HYPH
cord-016938-pk76snuy	254	38	loaded	loaded	JJ
cord-016938-pk76snuy	254	39	collagen	collagen	NN
cord-016938-pk76snuy	254	40	-	-	HYPH
cord-016938-pk76snuy	254	41	hyaluronic	hyaluronic	NN
cord-016938-pk76snuy	254	42	acid	acid	NN
cord-016938-pk76snuy	254	43	matrix	matrix	NN
cord-016938-pk76snuy	254	44	as	as	IN
cord-016938-pk76snuy	254	45	a	a	DT
cord-016938-pk76snuy	254	46	skin	skin	NN
cord-016938-pk76snuy	254	47	substitute	substitute	NN
cord-016938-pk76snuy	254	48	Electrospun	Electrospun	NNP
cord-016938-pk76snuy	254	49	nanofibrous	nanofibrous	JJ
cord-016938-pk76snuy	254	50	membrane	membrane	NN
cord-016938-pk76snuy	254	51	for	for	IN
cord-016938-pk76snuy	254	52	the	the	DT
cord-016938-pk76snuy	254	53	engineering	engineering	NN
cord-016938-pk76snuy	254	54	of	of	IN
cord-016938-pk76snuy	254	55	cultured	cultured	JJ
cord-016938-pk76snuy	254	56	skin	skin	NN
cord-016938-pk76snuy	254	57	substitutes	substitute	NNS
cord-016938-pk76snuy	254	58	Biodegradable	Biodegradable	NNP
cord-016938-pk76snuy	254	59	Ceramic	Ceramic	NNP
cord-016938-pk76snuy	254	60	-	-	HYPH
cord-016938-pk76snuy	254	61	Collagen	Collagen	NNP
cord-016938-pk76snuy	254	62	Composite	Composite	NNP
cord-016938-pk76snuy	254	63	Implanted	implant	VBN
cord-016938-pk76snuy	254	64	in	in	IN
cord-016938-pk76snuy	254	65	Rabbit	Rabbit	NNP
cord-016938-pk76snuy	254	66	Tibiae	Tibiae	NNP
cord-016938-pk76snuy	254	67	Behaviors	behavior	NNS
cord-016938-pk76snuy	254	68	of	of	IN
cord-016938-pk76snuy	254	69	Osteoblasts	Osteoblasts	NNP
cord-016938-pk76snuy	254	70	-	-	HYPH
cord-016938-pk76snuy	254	71	like	like	JJ
cord-016938-pk76snuy	254	72	Cell	cell	NN
cord-016938-pk76snuy	254	73	(	(	-LRB-
cord-016938-pk76snuy	254	74	MC3T3-E1	MC3T3-E1	NNP
cord-016938-pk76snuy	254	75	)	)	-RRB-
cord-016938-pk76snuy	254	76	on	on	IN
cord-016938-pk76snuy	255	1	Collagen	Collagen	NNP
cord-016938-pk76snuy	255	2	Grafted	Grafted	NNP
cord-016938-pk76snuy	255	3	Poly	Poly	NNP
cord-016938-pk76snuy	255	4	L	l	NN
cord-016938-pk76snuy	255	5	-	-	HYPH
cord-016938-pk76snuy	255	6	lactic	lactic	NN
cord-016938-pk76snuy	255	7	Acid	acid	NN
cord-016938-pk76snuy	255	8	(	(	-LRB-
cord-016938-pk76snuy	255	9	PLLA	PLLA	NNP
cord-016938-pk76snuy	255	10	)	)	-RRB-
cord-016938-pk76snuy	255	11	Membranes	membrane	NNS
cord-016938-pk76snuy	255	12	with	with	IN
cord-016938-pk76snuy	255	13	Various	various	JJ
cord-016938-pk76snuy	255	14	Pore	pore	NN
cord-016938-pk76snuy	255	15	Sizes	size	NNS
cord-016938-pk76snuy	256	1	A	a	DT
cord-016938-pk76snuy	256	2	Bone	Bone	NNP
cord-016938-pk76snuy	256	3	Replaceable	Replaceable	NNP
cord-016938-pk76snuy	256	4	Artificial	Artificial	NNP
cord-016938-pk76snuy	256	5	Bone	Bone	NNP
cord-016938-pk76snuy	256	6	Substitute	Substitute	NNP
cord-016938-pk76snuy	256	7	:	:	:
cord-016938-pk76snuy	257	1	Morphological	morphological	JJ
cord-016938-pk76snuy	257	2	and	and	CC
cord-016938-pk76snuy	257	3	Physicochemical	Physicochemical	NNP
cord-016938-pk76snuy	257	4	Characterization	Characterization	NNP
cord-016938-pk76snuy	257	5	Behavior	Behavior	NNP
cord-016938-pk76snuy	257	6	of	of	IN
cord-016938-pk76snuy	257	7	Osteoblasts	Osteoblasts	NNP
cord-016938-pk76snuy	257	8	on	on	IN
cord-016938-pk76snuy	257	9	type	type	NN
cord-016938-pk76snuy	258	1	I	-PRON-	PRP
cord-016938-pk76snuy	258	2	Atelocollagen	Atelocollagen	NNP
cord-016938-pk76snuy	258	3	Grafted	Grafted	NNP
cord-016938-pk76snuy	258	4	Ozone	ozone	NN
cord-016938-pk76snuy	258	5	Oxidized	oxidize	VBN
cord-016938-pk76snuy	258	6	Poly	Poly	NNP
cord-016938-pk76snuy	258	7	L	l	NN
cord-016938-pk76snuy	258	8	-	-	HYPH
cord-016938-pk76snuy	258	9	lactic	lactic	JJ
cord-016938-pk76snuy	259	1	Acid	acid	NN
cord-016938-pk76snuy	259	2	Membrane	Membrane	NNP
cord-016938-pk76snuy	260	1	A	a	DT
cord-016938-pk76snuy	260	2	Bone	Bone	NNP
cord-016938-pk76snuy	260	3	Replacable	Replacable	NNP
cord-016938-pk76snuy	260	4	Artificial	Artificial	NNP
cord-016938-pk76snuy	260	5	Bone	Bone	NNP
cord-016938-pk76snuy	260	6	Substittue	Substittue	NNP
cord-016938-pk76snuy	260	7	:	:	:
cord-016938-pk76snuy	260	8	Cytotoxicity	Cytotoxicity	NNP
cord-016938-pk76snuy	260	9	,	,	,
cord-016938-pk76snuy	260	10	Cell	cell	NN
cord-016938-pk76snuy	260	11	Adhesion	adhesion	NN
cord-016938-pk76snuy	260	12	,	,	,
cord-016938-pk76snuy	260	13	Proliferation	proliferation	NN
cord-016938-pk76snuy	260	14	,	,	,
cord-016938-pk76snuy	260	15	and	and	CC
cord-016938-pk76snuy	260	16	Alkaline	alkaline	JJ
cord-016938-pk76snuy	260	17	Phosphatase	Phosphatase	NNP
cord-016938-pk76snuy	260	18	Activity	Activity	NNP
cord-016938-pk76snuy	260	19	A	A	NNP
cord-016938-pk76snuy	260	20	Bone	Bone	NNP
cord-016938-pk76snuy	260	21	Replaceable	replaceable	JJ
cord-016938-pk76snuy	260	22	Artificial	Artificial	NNP
cord-016938-pk76snuy	260	23	Bone	Bone	NNP
cord-016938-pk76snuy	260	24	Substitute	Substitute	NNP
cord-016938-pk76snuy	260	25	:	:	:
cord-016938-pk76snuy	260	26	Osteoinduction	Osteoinduction	NNP
cord-016938-pk76snuy	260	27	by	by	IN
cord-016938-pk76snuy	260	28	combining	combine	VBG
cord-016938-pk76snuy	260	29	with	with	IN
cord-016938-pk76snuy	260	30	Bone	Bone	NNP
cord-016938-pk76snuy	260	31	Inducing	Inducing	NNP
cord-016938-pk76snuy	260	32	Agent	Agent	NNP
cord-016938-pk76snuy	260	33	Interaction	Interaction	NNP
cord-016938-pk76snuy	260	34	of	of	IN
cord-016938-pk76snuy	260	35	Mesenchymal	Mesenchymal	NNP
cord-016938-pk76snuy	260	36	Stem	Stem	NNP
cord-016938-pk76snuy	260	37	Cells	Cells	NNPS
cord-016938-pk76snuy	260	38	and	and	CC
cord-016938-pk76snuy	260	39	Osteoblasts	Osteoblasts	NNPS
cord-016938-pk76snuy	260	40	for	for	IN
cord-016938-pk76snuy	260	41	in	in	FW
cord-016938-pk76snuy	260	42	vitro	vitro	FW
cord-016938-pk76snuy	260	43	Osteogenesis	osteogenesis	NN
cord-016938-pk76snuy	260	44	Ex	Ex	NNP
cord-016938-pk76snuy	260	45	Vivo	Vivo	NNP
cord-016938-pk76snuy	260	46	Mechanical	Mechanical	NNP
cord-016938-pk76snuy	260	47	Evaluation	Evaluation	NNP
cord-016938-pk76snuy	260	48	of	of	IN
cord-016938-pk76snuy	260	49	Carbonate	Carbonate	NNP
cord-016938-pk76snuy	260	50	Apatite	Apatite	NNP
cord-016938-pk76snuy	260	51	-	-	HYPH
cord-016938-pk76snuy	260	52	Collagen	Collagen	NNP
cord-016938-pk76snuy	260	53	Grafted	graft	VBD
cord-016938-pk76snuy	260	54	Porous	Porous	NNP
cord-016938-pk76snuy	260	55	PLLA	PLLA	NNP
cord-016938-pk76snuy	260	56	Membrane	membrane	NN
cord-016938-pk76snuy	260	57	in	in	IN
cord-016938-pk76snuy	260	58	Rabbit	Rabbit	NNP
cord-016938-pk76snuy	260	59	Calvarial	Calvarial	NNP
cord-016938-pk76snuy	260	60	Bone	Bone	NNP
cord-016938-pk76snuy	260	61	Type	type	NN
cord-016938-pk76snuy	261	1	I	-PRON-	PRP
cord-016938-pk76snuy	261	2	Atelocollagen	Atelocollagen	NNP
cord-016938-pk76snuy	261	3	Grafting	graft	VBG
cord-016938-pk76snuy	261	4	on	on	IN
cord-016938-pk76snuy	261	5	Polyurethane	Polyurethane	NNP
cord-016938-pk76snuy	261	6	Tube	Tube	NNP
cord-016938-pk76snuy	261	7	and	and	CC
cord-016938-pk76snuy	261	8	its	-PRON-	PRP$
cord-016938-pk76snuy	261	9	Mechanical	Mechanical	NNP
cord-016938-pk76snuy	261	10	Property	Property	NNP
cord-016938-pk76snuy	261	11	Compliance	Compliance	NNP
cord-016938-pk76snuy	261	12	of	of	IN
cord-016938-pk76snuy	261	13	surface	surface	NN
cord-016938-pk76snuy	261	14	Modified	Modified	NNP
cord-016938-pk76snuy	261	15	Polyurethane	Polyurethane	NNP
cord-016938-pk76snuy	261	16	Tubular	Tubular	NNP
cord-016938-pk76snuy	261	17	Scaffold	Scaffold	NNP
cord-016938-pk76snuy	261	18	for	for	IN
cord-016938-pk76snuy	261	19	Artificial	artificial	JJ
cord-016938-pk76snuy	261	20	Esophagus	esophagus	NN
cord-016938-pk76snuy	261	21	Type	type	NN
cord-016938-pk76snuy	262	1	I	-PRON-	PRP
cord-016938-pk76snuy	262	2	Atelocollagen	Atelocollagen	NNP
cord-016938-pk76snuy	262	3	Grafting	graft	VBG
cord-016938-pk76snuy	262	4	onto	onto	IN
cord-016938-pk76snuy	262	5	Ozone	ozone	NN
cord-016938-pk76snuy	262	6	treated	treat	VBN
cord-016938-pk76snuy	262	7	Polyurethane	Polyurethane	NNP
cord-016938-pk76snuy	262	8	Films	Films	NNPS
cord-016938-pk76snuy	262	9	:	:	:
cord-016938-pk76snuy	263	1	Cell	cell	NN
cord-016938-pk76snuy	263	2	Attachment	Attachment	NNP
cord-016938-pk76snuy	263	3	,	,	,
cord-016938-pk76snuy	263	4	Proliferation	Proliferation	NNP
cord-016938-pk76snuy	263	5	,	,	,
cord-016938-pk76snuy	263	6	and	and	CC
cord-016938-pk76snuy	263	7	Collagen	Collagen	NNP
cord-016938-pk76snuy	263	8	Synthesis	Synthesis	NNP
cord-016938-pk76snuy	263	9	Time	time	NN
cord-016938-pk76snuy	263	10	-	-	HYPH
cord-016938-pk76snuy	263	11	dependent	dependent	JJ
cord-016938-pk76snuy	263	12	modulation	modulation	NN
cord-016938-pk76snuy	263	13	of	of	IN
cord-016938-pk76snuy	263	14	alignment	alignment	NN
cord-016938-pk76snuy	263	15	and	and	CC
cord-016938-pk76snuy	263	16	differentiation	differentiation	NN
cord-016938-pk76snuy	263	17	of	of	IN
cord-016938-pk76snuy	263	18	smooth	smooth	JJ
cord-016938-pk76snuy	263	19	muscle	muscle	NN
cord-016938-pk76snuy	263	20	cells	cell	NNS
cord-016938-pk76snuy	263	21	seeded	seed	VBN
cord-016938-pk76snuy	263	22	on	on	IN
cord-016938-pk76snuy	263	23	a	a	DT
cord-016938-pk76snuy	263	24	porous	porous	JJ
cord-016938-pk76snuy	263	25	substrate	substrate	NN
cord-016938-pk76snuy	263	26	undergoing	undergo	VBG
cord-016938-pk76snuy	263	27	cyclic	cyclic	JJ
cord-016938-pk76snuy	263	28	mechanical	mechanical	JJ
cord-016938-pk76snuy	263	29	strain	strain	NN
cord-016938-pk76snuy	263	30	Construction	construction	NN
cord-016938-pk76snuy	263	31	of	of	IN
cord-016938-pk76snuy	263	32	functional	functional	JJ
cord-016938-pk76snuy	263	33	soft	soft	JJ
cord-016938-pk76snuy	263	34	tissues	tissue	NNS
cord-016938-pk76snuy	263	35	from	from	IN
cord-016938-pk76snuy	263	36	premodulated	premodulated	JJ
cord-016938-pk76snuy	263	37	smooth	smooth	JJ
cord-016938-pk76snuy	263	38	muscle	muscle	NN
cord-016938-pk76snuy	263	39	cells	cell	NNS
cord-016938-pk76snuy	263	40	using	use	VBG
cord-016938-pk76snuy	263	41	a	a	DT
cord-016938-pk76snuy	263	42	bioreactor	bioreactor	NN
cord-016938-pk76snuy	263	43	system	system	NN
cord-016938-pk76snuy	263	44	Evaluation	evaluation	NN
cord-016938-pk76snuy	263	45	of	of	IN
cord-016938-pk76snuy	263	46	tissue	tissue	NN
cord-016938-pk76snuy	263	47	adhesion	adhesion	NN
cord-016938-pk76snuy	263	48	preventive	preventive	JJ
cord-016938-pk76snuy	263	49	surface	surface	NN
cord-016938-pk76snuy	263	50	modified	modify	VBN
cord-016938-pk76snuy	263	51	natural	natural	JJ
cord-016938-pk76snuy	263	52	and	and	CC
cord-016938-pk76snuy	263	53	synthetic	synthetic	JJ
cord-016938-pk76snuy	263	54	polymeric	polymeric	JJ
cord-016938-pk76snuy	263	55	materials	material	NNS
cord-016938-pk76snuy	263	56	Preparation	preparation	NN
cord-016938-pk76snuy	263	57	and	and	CC
cord-016938-pk76snuy	263	58	characterization	characterization	NN
cord-016938-pk76snuy	263	59	of	of	IN
cord-016938-pk76snuy	263	60	biodegradable	biodegradable	JJ
cord-016938-pk76snuy	263	61	anti	anti	JJ
cord-016938-pk76snuy	263	62	-	-	JJ
cord-016938-pk76snuy	263	63	adhesive	adhesive	JJ
cord-016938-pk76snuy	263	64	membrane	membrane	NN
cord-016938-pk76snuy	263	65	for	for	IN
cord-016938-pk76snuy	263	66	peritoneal	peritoneal	JJ
cord-016938-pk76snuy	263	67	wound	wound	NN
cord-016938-pk76snuy	263	68	healing	heal	VBG
cord-016938-pk76snuy	263	69	Behaviors	behavior	NNS
cord-016938-pk76snuy	263	70	of	of	IN
cord-016938-pk76snuy	263	71	isolated	isolate	VBN
cord-016938-pk76snuy	263	72	rat	rat	NN
cord-016938-pk76snuy	263	73	oval	oval	JJ
cord-016938-pk76snuy	263	74	cells	cell	NNS
cord-016938-pk76snuy	263	75	in	in	IN
cord-016938-pk76snuy	263	76	porous	porous	JJ
cord-016938-pk76snuy	263	77	collagen	collagen	NN
cord-016938-pk76snuy	263	78	scaffold	scaffold	NN