id sid tid token lemma pos cord-325712-9kbnyqt3 1 1 key key NN cord-325712-9kbnyqt3 1 2 : : : cord-325712-9kbnyqt3 2 1 cord-325712 cord-325712 JJ cord-325712-9kbnyqt3 2 2 - - HYPH cord-325712-9kbnyqt3 2 3 9kbnyqt3 9kbnyqt3 CD cord-325712-9kbnyqt3 2 4 authors author NNS cord-325712-9kbnyqt3 2 5 : : : cord-325712-9kbnyqt3 2 6 Nathan Nathan NNP cord-325712-9kbnyqt3 2 7 , , , cord-325712-9kbnyqt3 2 8 Lakshmi Lakshmi NNP cord-325712-9kbnyqt3 2 9 ; ; : cord-325712-9kbnyqt3 2 10 Daniel Daniel NNP cord-325712-9kbnyqt3 2 11 , , , cord-325712-9kbnyqt3 2 12 Susan Susan NNP cord-325712-9kbnyqt3 2 13 title title NN cord-325712-9kbnyqt3 2 14 : : : cord-325712-9kbnyqt3 2 15 Single single JJ cord-325712-9kbnyqt3 2 16 Virion virion NN cord-325712-9kbnyqt3 2 17 Tracking tracking NN cord-325712-9kbnyqt3 2 18 Microscopy Microscopy NNP cord-325712-9kbnyqt3 2 19 for for IN cord-325712-9kbnyqt3 2 20 the the DT cord-325712-9kbnyqt3 2 21 Study Study NNP cord-325712-9kbnyqt3 2 22 of of IN cord-325712-9kbnyqt3 2 23 Virus Virus NNP cord-325712-9kbnyqt3 2 24 Entry Entry NNP cord-325712-9kbnyqt3 2 25 Processes Processes NNPS cord-325712-9kbnyqt3 2 26 in in IN cord-325712-9kbnyqt3 2 27 Live live JJ cord-325712-9kbnyqt3 2 28 Cells cell NNS cord-325712-9kbnyqt3 2 29 and and CC cord-325712-9kbnyqt3 3 1 Biomimetic Biomimetic NNP cord-325712-9kbnyqt3 3 2 Platforms Platforms NNP cord-325712-9kbnyqt3 3 3 date date NN cord-325712-9kbnyqt3 3 4 : : : cord-325712-9kbnyqt3 3 5 2019 2019 CD cord-325712-9kbnyqt3 3 6 - - HYPH cord-325712-9kbnyqt3 3 7 07 07 CD cord-325712-9kbnyqt3 3 8 - - SYM cord-325712-9kbnyqt3 3 9 18 18 CD cord-325712-9kbnyqt3 3 10 journal journal NN cord-325712-9kbnyqt3 3 11 : : : cord-325712-9kbnyqt3 3 12 Physical Physical NNP cord-325712-9kbnyqt3 3 13 Virology Virology NNP cord-325712-9kbnyqt3 3 14 DOI doi NN cord-325712-9kbnyqt3 3 15 : : : cord-325712-9kbnyqt3 3 16 10.1007/978 10.1007/978 CD cord-325712-9kbnyqt3 3 17 - - HYPH cord-325712-9kbnyqt3 3 18 3 3 CD cord-325712-9kbnyqt3 3 19 - - HYPH cord-325712-9kbnyqt3 3 20 030 030 CD cord-325712-9kbnyqt3 3 21 - - HYPH cord-325712-9kbnyqt3 3 22 14741 14741 CD cord-325712-9kbnyqt3 3 23 - - SYM cord-325712-9kbnyqt3 3 24 9_2 9_2 CD cord-325712-9kbnyqt3 3 25 sha sha NN cord-325712-9kbnyqt3 3 26 : : : cord-325712-9kbnyqt3 3 27 1fef777f0d7c519231aac4fa514c2821d1a60750 1fef777f0d7c519231aac4fa514c2821d1a60750 CD cord-325712-9kbnyqt3 3 28 doc_id doc_id CD cord-325712-9kbnyqt3 3 29 : : : cord-325712-9kbnyqt3 3 30 325712 325712 CD cord-325712-9kbnyqt3 3 31 cord_uid cord_uid NN cord-325712-9kbnyqt3 3 32 : : : cord-325712-9kbnyqt3 4 1 9kbnyqt3 9kbnyqt3 CD cord-325712-9kbnyqt3 5 1 The the DT cord-325712-9kbnyqt3 5 2 most most RBS cord-325712-9kbnyqt3 5 3 widely widely RB cord-325712-9kbnyqt3 5 4 - - HYPH cord-325712-9kbnyqt3 5 5 used use VBN cord-325712-9kbnyqt3 5 6 assays assay NNS cord-325712-9kbnyqt3 5 7 for for IN cord-325712-9kbnyqt3 5 8 studying study VBG cord-325712-9kbnyqt3 5 9 viral viral JJ cord-325712-9kbnyqt3 5 10 entry entry NN cord-325712-9kbnyqt3 5 11 , , , cord-325712-9kbnyqt3 5 12 including include VBG cord-325712-9kbnyqt3 5 13 infectivity infectivity NN cord-325712-9kbnyqt3 5 14 , , , cord-325712-9kbnyqt3 5 15 cofloatation cofloatation NN cord-325712-9kbnyqt3 5 16 , , , cord-325712-9kbnyqt3 5 17 and and CC cord-325712-9kbnyqt3 5 18 cell cell NN cord-325712-9kbnyqt3 5 19 - - HYPH cord-325712-9kbnyqt3 5 20 cell cell NN cord-325712-9kbnyqt3 5 21 fusion fusion NN cord-325712-9kbnyqt3 5 22 assays assay NNS cord-325712-9kbnyqt3 5 23 , , , cord-325712-9kbnyqt3 5 24 yield yield VB cord-325712-9kbnyqt3 5 25 functional functional JJ cord-325712-9kbnyqt3 5 26 information information NN cord-325712-9kbnyqt3 5 27 but but CC cord-325712-9kbnyqt3 5 28 provide provide VB cord-325712-9kbnyqt3 5 29 low low JJ cord-325712-9kbnyqt3 5 30 resolution resolution NN cord-325712-9kbnyqt3 5 31 of of IN cord-325712-9kbnyqt3 5 32 individual individual JJ cord-325712-9kbnyqt3 5 33 entry entry NN cord-325712-9kbnyqt3 5 34 steps step NNS cord-325712-9kbnyqt3 5 35 . . . cord-325712-9kbnyqt3 6 1 Structural structural JJ cord-325712-9kbnyqt3 6 2 characterization characterization NN cord-325712-9kbnyqt3 6 3 provides provide VBZ cord-325712-9kbnyqt3 6 4 high high JJ cord-325712-9kbnyqt3 6 5 - - HYPH cord-325712-9kbnyqt3 6 6 resolution resolution NN cord-325712-9kbnyqt3 6 7 conformational conformational JJ cord-325712-9kbnyqt3 6 8 information information NN cord-325712-9kbnyqt3 6 9 , , , cord-325712-9kbnyqt3 6 10 but but CC cord-325712-9kbnyqt3 6 11 on on IN cord-325712-9kbnyqt3 6 12 its -PRON- PRP$ cord-325712-9kbnyqt3 6 13 own own JJ cord-325712-9kbnyqt3 6 14 is be VBZ cord-325712-9kbnyqt3 6 15 unable unable JJ cord-325712-9kbnyqt3 6 16 to to TO cord-325712-9kbnyqt3 6 17 address address VB cord-325712-9kbnyqt3 6 18 the the DT cord-325712-9kbnyqt3 6 19 functional functional JJ cord-325712-9kbnyqt3 6 20 significance significance NN cord-325712-9kbnyqt3 6 21 of of IN cord-325712-9kbnyqt3 6 22 these these DT cord-325712-9kbnyqt3 6 23 conformations conformation NNS cord-325712-9kbnyqt3 6 24 . . . cord-325712-9kbnyqt3 7 1 Single single JJ cord-325712-9kbnyqt3 7 2 virion virion NN cord-325712-9kbnyqt3 7 3 tracking track VBG cord-325712-9kbnyqt3 7 4 microscopy microscopy NN cord-325712-9kbnyqt3 7 5 techniques technique NNS cord-325712-9kbnyqt3 7 6 provide provide VBP cord-325712-9kbnyqt3 7 7 more more JJR cord-325712-9kbnyqt3 7 8 detail detail NN cord-325712-9kbnyqt3 7 9 on on IN cord-325712-9kbnyqt3 7 10 the the DT cord-325712-9kbnyqt3 7 11 intermediate intermediate JJ cord-325712-9kbnyqt3 7 12 entry entry NN cord-325712-9kbnyqt3 7 13 steps step NNS cord-325712-9kbnyqt3 7 14 than than IN cord-325712-9kbnyqt3 7 15 infection infection NN cord-325712-9kbnyqt3 7 16 assays assay NNS cord-325712-9kbnyqt3 7 17 and and CC cord-325712-9kbnyqt3 7 18 more more JJR cord-325712-9kbnyqt3 7 19 functional functional JJ cord-325712-9kbnyqt3 7 20 information information NN cord-325712-9kbnyqt3 7 21 than than IN cord-325712-9kbnyqt3 7 22 structural structural JJ cord-325712-9kbnyqt3 7 23 methods method NNS cord-325712-9kbnyqt3 7 24 , , , cord-325712-9kbnyqt3 7 25 bridging bridge VBG cord-325712-9kbnyqt3 7 26 the the DT cord-325712-9kbnyqt3 7 27 gap gap NN cord-325712-9kbnyqt3 7 28 between between IN cord-325712-9kbnyqt3 7 29 these these DT cord-325712-9kbnyqt3 7 30 methods method NNS cord-325712-9kbnyqt3 7 31 . . . cord-325712-9kbnyqt3 8 1 In in IN cord-325712-9kbnyqt3 8 2 addition addition NN cord-325712-9kbnyqt3 8 3 , , , cord-325712-9kbnyqt3 8 4 single single JJ cord-325712-9kbnyqt3 8 5 virion virion NN cord-325712-9kbnyqt3 8 6 approaches approach NNS cord-325712-9kbnyqt3 8 7 also also RB cord-325712-9kbnyqt3 8 8 provide provide VBP cord-325712-9kbnyqt3 8 9 dynamic dynamic JJ cord-325712-9kbnyqt3 8 10 information information NN cord-325712-9kbnyqt3 8 11 about about IN cord-325712-9kbnyqt3 8 12 the the DT cord-325712-9kbnyqt3 8 13 kinetics kinetic NNS cord-325712-9kbnyqt3 8 14 of of IN cord-325712-9kbnyqt3 8 15 entry entry NN cord-325712-9kbnyqt3 8 16 processes process NNS cord-325712-9kbnyqt3 8 17 . . . cord-325712-9kbnyqt3 9 1 This this DT cord-325712-9kbnyqt3 9 2 chapter chapter NN cord-325712-9kbnyqt3 9 3 reviews review VBZ cord-325712-9kbnyqt3 9 4 single single JJ cord-325712-9kbnyqt3 9 5 virion virion NN cord-325712-9kbnyqt3 9 6 tracking tracking NN cord-325712-9kbnyqt3 9 7 techniques technique NNS cord-325712-9kbnyqt3 9 8 and and CC cord-325712-9kbnyqt3 9 9 describes describe VBZ cord-325712-9kbnyqt3 9 10 how how WRB cord-325712-9kbnyqt3 9 11 they -PRON- PRP cord-325712-9kbnyqt3 9 12 can can MD cord-325712-9kbnyqt3 9 13 be be VB cord-325712-9kbnyqt3 9 14 applied apply VBN cord-325712-9kbnyqt3 9 15 to to TO cord-325712-9kbnyqt3 9 16 study study VB cord-325712-9kbnyqt3 9 17 specific specific JJ cord-325712-9kbnyqt3 9 18 virus virus NN cord-325712-9kbnyqt3 9 19 entry entry NN cord-325712-9kbnyqt3 9 20 steps step NNS cord-325712-9kbnyqt3 9 21 . . . cord-325712-9kbnyqt3 10 1 These these DT cord-325712-9kbnyqt3 10 2 techniques technique NNS cord-325712-9kbnyqt3 10 3 provide provide VBP cord-325712-9kbnyqt3 10 4 information information NN cord-325712-9kbnyqt3 10 5 complementary complementary JJ cord-325712-9kbnyqt3 10 6 to to IN cord-325712-9kbnyqt3 10 7 traditional traditional JJ cord-325712-9kbnyqt3 10 8 ensemble ensemble NN cord-325712-9kbnyqt3 10 9 approaches approach NNS cord-325712-9kbnyqt3 10 10 . . . cord-325712-9kbnyqt3 11 1 Single single JJ cord-325712-9kbnyqt3 11 2 virion virion NN cord-325712-9kbnyqt3 11 3 techniques technique NNS cord-325712-9kbnyqt3 11 4 may may MD cord-325712-9kbnyqt3 11 5 either either RB cord-325712-9kbnyqt3 11 6 probe probe VB cord-325712-9kbnyqt3 11 7 virion virion NN cord-325712-9kbnyqt3 11 8 behavior behavior NN cord-325712-9kbnyqt3 11 9 in in IN cord-325712-9kbnyqt3 11 10 live live JJ cord-325712-9kbnyqt3 11 11 cells cell NNS cord-325712-9kbnyqt3 11 12 or or CC cord-325712-9kbnyqt3 11 13 in in IN cord-325712-9kbnyqt3 11 14 biomimetic biomimetic JJ cord-325712-9kbnyqt3 11 15 platforms platform NNS cord-325712-9kbnyqt3 11 16 . . . cord-325712-9kbnyqt3 12 1 Synthesizing synthesize VBG cord-325712-9kbnyqt3 12 2 information information NN cord-325712-9kbnyqt3 12 3 from from IN cord-325712-9kbnyqt3 12 4 ensemble ensemble NN cord-325712-9kbnyqt3 12 5 , , , cord-325712-9kbnyqt3 12 6 structural structural JJ cord-325712-9kbnyqt3 12 7 , , , cord-325712-9kbnyqt3 12 8 and and CC cord-325712-9kbnyqt3 12 9 single single JJ cord-325712-9kbnyqt3 12 10 virion virion NN cord-325712-9kbnyqt3 12 11 techniques technique NNS cord-325712-9kbnyqt3 12 12 ultimately ultimately RB cord-325712-9kbnyqt3 12 13 yields yield VBZ cord-325712-9kbnyqt3 12 14 a a DT cord-325712-9kbnyqt3 12 15 more more RBR cord-325712-9kbnyqt3 12 16 complete complete JJ cord-325712-9kbnyqt3 12 17 understanding understanding NN cord-325712-9kbnyqt3 12 18 of of IN cord-325712-9kbnyqt3 12 19 the the DT cord-325712-9kbnyqt3 12 20 viral viral JJ cord-325712-9kbnyqt3 12 21 entry entry NN cord-325712-9kbnyqt3 12 22 process process NN cord-325712-9kbnyqt3 12 23 than than IN cord-325712-9kbnyqt3 12 24 can can MD cord-325712-9kbnyqt3 12 25 be be VB cord-325712-9kbnyqt3 12 26 achieved achieve VBN cord-325712-9kbnyqt3 12 27 by by IN cord-325712-9kbnyqt3 12 28 any any DT cord-325712-9kbnyqt3 12 29 single single JJ cord-325712-9kbnyqt3 12 30 method method NN cord-325712-9kbnyqt3 12 31 alone alone RB cord-325712-9kbnyqt3 12 32 . . . cord-325712-9kbnyqt3 13 1 called call VBN cord-325712-9kbnyqt3 13 2 spikes spike NNS cord-325712-9kbnyqt3 13 3 . . . cord-325712-9kbnyqt3 14 1 The the DT cord-325712-9kbnyqt3 14 2 coat coat NN cord-325712-9kbnyqt3 14 3 protein protein NN cord-325712-9kbnyqt3 14 4 of of IN cord-325712-9kbnyqt3 14 5 non non JJ cord-325712-9kbnyqt3 14 6 - - JJ cord-325712-9kbnyqt3 14 7 enveloped enveloped JJ cord-325712-9kbnyqt3 14 8 viruses virus NNS cord-325712-9kbnyqt3 14 9 and and CC cord-325712-9kbnyqt3 14 10 spike spike NN cord-325712-9kbnyqt3 14 11 proteins protein NNS cord-325712-9kbnyqt3 14 12 of of IN cord-325712-9kbnyqt3 14 13 enveloped envelop VBN cord-325712-9kbnyqt3 14 14 viruses virus NNS cord-325712-9kbnyqt3 14 15 facilitate facilitate VBP cord-325712-9kbnyqt3 14 16 the the DT cord-325712-9kbnyqt3 14 17 virus virus NN cord-325712-9kbnyqt3 14 18 's 's POS cord-325712-9kbnyqt3 14 19 entry entry NN cord-325712-9kbnyqt3 14 20 into into IN cord-325712-9kbnyqt3 14 21 the the DT cord-325712-9kbnyqt3 14 22 cell cell NN cord-325712-9kbnyqt3 14 23 . . . cord-325712-9kbnyqt3 15 1 These these DT cord-325712-9kbnyqt3 15 2 viral viral JJ cord-325712-9kbnyqt3 15 3 proteins protein NNS cord-325712-9kbnyqt3 15 4 engage engage VBP cord-325712-9kbnyqt3 15 5 receptors receptor NNS cord-325712-9kbnyqt3 15 6 on on IN cord-325712-9kbnyqt3 15 7 host host NN cord-325712-9kbnyqt3 15 8 cells cell NNS cord-325712-9kbnyqt3 15 9 to to TO cord-325712-9kbnyqt3 15 10 promote promote VB cord-325712-9kbnyqt3 15 11 attachment attachment NN cord-325712-9kbnyqt3 15 12 to to IN cord-325712-9kbnyqt3 15 13 the the DT cord-325712-9kbnyqt3 15 14 host host NN cord-325712-9kbnyqt3 15 15 cell cell NN cord-325712-9kbnyqt3 15 16 surface surface NN cord-325712-9kbnyqt3 15 17 , , , cord-325712-9kbnyqt3 15 18 but but CC cord-325712-9kbnyqt3 15 19 after after IN cord-325712-9kbnyqt3 15 20 that that DT cord-325712-9kbnyqt3 15 21 initial initial JJ cord-325712-9kbnyqt3 15 22 binding binding NN cord-325712-9kbnyqt3 15 23 event event NN cord-325712-9kbnyqt3 15 24 , , , cord-325712-9kbnyqt3 15 25 non non JJ cord-325712-9kbnyqt3 15 26 - - JJ cord-325712-9kbnyqt3 15 27 enveloped enveloped JJ cord-325712-9kbnyqt3 15 28 and and CC cord-325712-9kbnyqt3 15 29 enveloped envelop VBN cord-325712-9kbnyqt3 15 30 viruses virus NNS cord-325712-9kbnyqt3 15 31 breach breach VB cord-325712-9kbnyqt3 15 32 host host NN cord-325712-9kbnyqt3 15 33 cell cell NN cord-325712-9kbnyqt3 15 34 membranes membrane NNS cord-325712-9kbnyqt3 15 35 through through IN cord-325712-9kbnyqt3 15 36 different different JJ cord-325712-9kbnyqt3 15 37 pathways pathway NNS cord-325712-9kbnyqt3 15 38 [ [ -LRB- cord-325712-9kbnyqt3 15 39 1 1 CD cord-325712-9kbnyqt3 15 40 ] ] -RRB- cord-325712-9kbnyqt3 15 41 . . . cord-325712-9kbnyqt3 16 1 Non Non NNS cord-325712-9kbnyqt3 16 2 - - JJ cord-325712-9kbnyqt3 16 3 enveloped enveloped JJ cord-325712-9kbnyqt3 16 4 viruses virus NNS cord-325712-9kbnyqt3 16 5 typically typically RB cord-325712-9kbnyqt3 16 6 enter enter VBP cord-325712-9kbnyqt3 16 7 cells cell NNS cord-325712-9kbnyqt3 16 8 by by IN cord-325712-9kbnyqt3 16 9 endocytosis endocytosis NN cord-325712-9kbnyqt3 16 10 and and CC cord-325712-9kbnyqt3 16 11 then then RB cord-325712-9kbnyqt3 16 12 either either CC cord-325712-9kbnyqt3 16 13 lyse lyse VB cord-325712-9kbnyqt3 16 14 the the DT cord-325712-9kbnyqt3 16 15 intracellular intracellular JJ cord-325712-9kbnyqt3 16 16 compartment compartment NN cord-325712-9kbnyqt3 16 17 , , , cord-325712-9kbnyqt3 16 18 or or CC cord-325712-9kbnyqt3 16 19 release release VB cord-325712-9kbnyqt3 16 20 genetic genetic JJ cord-325712-9kbnyqt3 16 21 material material NN cord-325712-9kbnyqt3 16 22 through through IN cord-325712-9kbnyqt3 16 23 a a DT cord-325712-9kbnyqt3 16 24 pore pore NN cord-325712-9kbnyqt3 16 25 created create VBN cord-325712-9kbnyqt3 16 26 in in IN cord-325712-9kbnyqt3 16 27 the the DT cord-325712-9kbnyqt3 16 28 membrane membrane NN cord-325712-9kbnyqt3 16 29 of of IN cord-325712-9kbnyqt3 16 30 the the DT cord-325712-9kbnyqt3 16 31 intracellular intracellular JJ cord-325712-9kbnyqt3 16 32 compartment compartment NN cord-325712-9kbnyqt3 16 33 [ [ -LRB- cord-325712-9kbnyqt3 16 34 2 2 CD cord-325712-9kbnyqt3 16 35 , , , cord-325712-9kbnyqt3 16 36 3 3 CD cord-325712-9kbnyqt3 16 37 ] ] -RRB- cord-325712-9kbnyqt3 16 38 . . . cord-325712-9kbnyqt3 17 1 Enveloped envelop VBN cord-325712-9kbnyqt3 17 2 viruses virus NNS cord-325712-9kbnyqt3 17 3 , , , cord-325712-9kbnyqt3 17 4 on on IN cord-325712-9kbnyqt3 17 5 the the DT cord-325712-9kbnyqt3 17 6 other other JJ cord-325712-9kbnyqt3 17 7 hand hand NN cord-325712-9kbnyqt3 17 8 , , , cord-325712-9kbnyqt3 17 9 must must MD cord-325712-9kbnyqt3 17 10 undergo undergo VB cord-325712-9kbnyqt3 17 11 membrane membrane NN cord-325712-9kbnyqt3 17 12 fusion fusion NN cord-325712-9kbnyqt3 17 13 with with IN cord-325712-9kbnyqt3 17 14 a a DT cord-325712-9kbnyqt3 17 15 cellular cellular JJ cord-325712-9kbnyqt3 17 16 membrane membrane NN cord-325712-9kbnyqt3 17 17 to to TO cord-325712-9kbnyqt3 17 18 release release VB cord-325712-9kbnyqt3 17 19 their -PRON- PRP$ cord-325712-9kbnyqt3 17 20 genetic genetic JJ cord-325712-9kbnyqt3 17 21 material material NN cord-325712-9kbnyqt3 17 22 into into IN cord-325712-9kbnyqt3 17 23 the the DT cord-325712-9kbnyqt3 17 24 host host NN cord-325712-9kbnyqt3 17 25 cell cell NN cord-325712-9kbnyqt3 17 26 ( ( -LRB- cord-325712-9kbnyqt3 17 27 Fig Fig NNP cord-325712-9kbnyqt3 17 28 . . . cord-325712-9kbnyqt3 17 29 2.1 2.1 CD cord-325712-9kbnyqt3 17 30 ) ) -RRB- cord-325712-9kbnyqt3 17 31 . . . cord-325712-9kbnyqt3 18 1 Some some DT cord-325712-9kbnyqt3 18 2 enveloped envelop VBN cord-325712-9kbnyqt3 18 3 viruses virus NNS cord-325712-9kbnyqt3 18 4 , , , cord-325712-9kbnyqt3 18 5 like like IN cord-325712-9kbnyqt3 18 6 coronaviruses coronaviruse NNS cord-325712-9kbnyqt3 18 7 or or CC cord-325712-9kbnyqt3 18 8 human human JJ cord-325712-9kbnyqt3 18 9 immunodeficiency immunodeficiency NN cord-325712-9kbnyqt3 18 10 virus virus NN cord-325712-9kbnyqt3 18 11 ( ( -LRB- cord-325712-9kbnyqt3 18 12 HIV HIV NNP cord-325712-9kbnyqt3 18 13 ) ) -RRB- cord-325712-9kbnyqt3 18 14 , , , cord-325712-9kbnyqt3 18 15 can can MD cord-325712-9kbnyqt3 18 16 undergo undergo VB cord-325712-9kbnyqt3 18 17 fusion fusion NN cord-325712-9kbnyqt3 18 18 at at IN cord-325712-9kbnyqt3 18 19 the the DT cord-325712-9kbnyqt3 18 20 plasma plasma NN cord-325712-9kbnyqt3 18 21 membrane membrane NN cord-325712-9kbnyqt3 18 22 ( ( -LRB- cord-325712-9kbnyqt3 18 23 A a NN cord-325712-9kbnyqt3 18 24 ) ) -RRB- cord-325712-9kbnyqt3 18 25 , , , cord-325712-9kbnyqt3 18 26 while while IN cord-325712-9kbnyqt3 18 27 others other NNS cord-325712-9kbnyqt3 18 28 , , , cord-325712-9kbnyqt3 18 29 like like IN cord-325712-9kbnyqt3 18 30 influenza influenza NN cord-325712-9kbnyqt3 18 31 , , , cord-325712-9kbnyqt3 18 32 fuse fuse VB cord-325712-9kbnyqt3 18 33 within within IN cord-325712-9kbnyqt3 18 34 endosomes endosome NNS cord-325712-9kbnyqt3 18 35 ( ( -LRB- cord-325712-9kbnyqt3 18 36 B b NN cord-325712-9kbnyqt3 18 37 ) ) -RRB- cord-325712-9kbnyqt3 18 38 [ [ -LRB- cord-325712-9kbnyqt3 18 39 4 4 CD cord-325712-9kbnyqt3 18 40 ] ] -RRB- cord-325712-9kbnyqt3 18 41 . . . cord-325712-9kbnyqt3 19 1 Binding bind VBG cord-325712-9kbnyqt3 19 2 and and CC cord-325712-9kbnyqt3 19 3 uncoating uncoating NN cord-325712-9kbnyqt3 19 4 of of IN cord-325712-9kbnyqt3 19 5 nonenveloped nonenveloped JJ cord-325712-9kbnyqt3 19 6 viruses virus NNS cord-325712-9kbnyqt3 19 7 is be VBZ cord-325712-9kbnyqt3 19 8 mediated mediate VBN cord-325712-9kbnyqt3 19 9 by by IN cord-325712-9kbnyqt3 19 10 the the DT cord-325712-9kbnyqt3 19 11 capsid capsid NN cord-325712-9kbnyqt3 19 12 surface surface NN cord-325712-9kbnyqt3 19 13 or or CC cord-325712-9kbnyqt3 19 14 capsid capsid NN cord-325712-9kbnyqt3 19 15 proteins protein NNS cord-325712-9kbnyqt3 19 16 projecting project VBG cord-325712-9kbnyqt3 19 17 from from IN cord-325712-9kbnyqt3 19 18 it -PRON- PRP cord-325712-9kbnyqt3 19 19 . . . cord-325712-9kbnyqt3 20 1 For for IN cord-325712-9kbnyqt3 20 2 enveloped envelop VBN cord-325712-9kbnyqt3 20 3 viruses virus NNS cord-325712-9kbnyqt3 20 4 , , , cord-325712-9kbnyqt3 20 5 the the DT cord-325712-9kbnyqt3 20 6 fusion fusion NN cord-325712-9kbnyqt3 20 7 or or CC cord-325712-9kbnyqt3 20 8 spike spike NN cord-325712-9kbnyqt3 20 9 proteins protein NNS cord-325712-9kbnyqt3 20 10 embedded embed VBN cord-325712-9kbnyqt3 20 11 in in IN cord-325712-9kbnyqt3 20 12 the the DT cord-325712-9kbnyqt3 20 13 envelope envelope NN cord-325712-9kbnyqt3 20 14 are be VBP cord-325712-9kbnyqt3 20 15 responsible responsible JJ cord-325712-9kbnyqt3 20 16 for for IN cord-325712-9kbnyqt3 20 17 both both DT cord-325712-9kbnyqt3 20 18 receptor receptor NN cord-325712-9kbnyqt3 20 19 binding binding NN cord-325712-9kbnyqt3 20 20 and and CC cord-325712-9kbnyqt3 20 21 membrane membrane NN cord-325712-9kbnyqt3 20 22 fusion fusion NN cord-325712-9kbnyqt3 20 23 . . . cord-325712-9kbnyqt3 21 1 Membrane membrane NN cord-325712-9kbnyqt3 21 2 fusion fusion NN cord-325712-9kbnyqt3 21 3 proteins protein NNS cord-325712-9kbnyqt3 21 4 can can MD cord-325712-9kbnyqt3 21 5 be be VB cord-325712-9kbnyqt3 21 6 subdivided subdivide VBN cord-325712-9kbnyqt3 21 7 into into IN cord-325712-9kbnyqt3 21 8 three three CD cord-325712-9kbnyqt3 21 9 categories category NNS cord-325712-9kbnyqt3 21 10 based base VBN cord-325712-9kbnyqt3 21 11 on on IN cord-325712-9kbnyqt3 21 12 their -PRON- PRP$ cord-325712-9kbnyqt3 21 13 structure structure NN cord-325712-9kbnyqt3 21 14 [ [ -LRB- cord-325712-9kbnyqt3 21 15 5 5 CD cord-325712-9kbnyqt3 21 16 ] ] -RRB- cord-325712-9kbnyqt3 21 17 . . . cord-325712-9kbnyqt3 22 1 Class class NN cord-325712-9kbnyqt3 22 2 I -PRON- PRP cord-325712-9kbnyqt3 22 3 fusion fusion NN cord-325712-9kbnyqt3 22 4 proteins protein NNS cord-325712-9kbnyqt3 22 5 are be VBP cord-325712-9kbnyqt3 22 6 primarily primarily RB cord-325712-9kbnyqt3 22 7 α α NN cord-325712-9kbnyqt3 22 8 - - HYPH cord-325712-9kbnyqt3 22 9 helical helical JJ cord-325712-9kbnyqt3 22 10 , , , cord-325712-9kbnyqt3 22 11 Class Class NNP cord-325712-9kbnyqt3 22 12 II II NNP cord-325712-9kbnyqt3 22 13 fusion fusion NN cord-325712-9kbnyqt3 22 14 proteins protein NNS cord-325712-9kbnyqt3 22 15 contain contain VBP cord-325712-9kbnyqt3 22 16 mainly mainly RB cord-325712-9kbnyqt3 22 17 β β NN cord-325712-9kbnyqt3 22 18 - - HYPH cord-325712-9kbnyqt3 22 19 sheets sheet NNS cord-325712-9kbnyqt3 22 20 and and CC cord-325712-9kbnyqt3 22 21 β β NN cord-325712-9kbnyqt3 22 22 - - HYPH cord-325712-9kbnyqt3 22 23 strands strand NNS cord-325712-9kbnyqt3 22 24 , , , cord-325712-9kbnyqt3 22 25 and and CC cord-325712-9kbnyqt3 22 26 Class Class NNP cord-325712-9kbnyqt3 22 27 III III NNP cord-325712-9kbnyqt3 22 28 fusion fusion NN cord-325712-9kbnyqt3 22 29 proteins protein NNS cord-325712-9kbnyqt3 22 30 contain contain VBP cord-325712-9kbnyqt3 22 31 a a DT cord-325712-9kbnyqt3 22 32 mix mix NN cord-325712-9kbnyqt3 22 33 of of IN cord-325712-9kbnyqt3 22 34 both both CC cord-325712-9kbnyqt3 22 35 α α NN cord-325712-9kbnyqt3 22 36 - - HYPH cord-325712-9kbnyqt3 22 37 helices helix NNS cord-325712-9kbnyqt3 22 38 and and CC cord-325712-9kbnyqt3 22 39 β β NN cord-325712-9kbnyqt3 22 40 - - HYPH cord-325712-9kbnyqt3 22 41 sheets sheet NNS cord-325712-9kbnyqt3 22 42 . . . cord-325712-9kbnyqt3 23 1 Class class NN cord-325712-9kbnyqt3 23 2 I i NN cord-325712-9kbnyqt3 23 3 and and CC cord-325712-9kbnyqt3 23 4 II II NNP cord-325712-9kbnyqt3 23 5 fusion fusion NN cord-325712-9kbnyqt3 23 6 proteins protein NNS cord-325712-9kbnyqt3 23 7 require require VBP cord-325712-9kbnyqt3 23 8 a a DT cord-325712-9kbnyqt3 23 9 proteolytic proteolytic JJ cord-325712-9kbnyqt3 23 10 priming priming NN cord-325712-9kbnyqt3 23 11 event event NN cord-325712-9kbnyqt3 23 12 to to TO cord-325712-9kbnyqt3 23 13 convert convert VB cord-325712-9kbnyqt3 23 14 them -PRON- PRP cord-325712-9kbnyqt3 23 15 from from IN cord-325712-9kbnyqt3 23 16 a a DT cord-325712-9kbnyqt3 23 17 fusion fusion NN cord-325712-9kbnyqt3 23 18 - - HYPH cord-325712-9kbnyqt3 23 19 incompetent incompetent JJ cord-325712-9kbnyqt3 23 20 state state NN cord-325712-9kbnyqt3 23 21 to to IN cord-325712-9kbnyqt3 23 22 a a DT cord-325712-9kbnyqt3 23 23 fusioncompetent fusioncompetent NN cord-325712-9kbnyqt3 23 24 one one NN cord-325712-9kbnyqt3 23 25 . . . cord-325712-9kbnyqt3 24 1 Once once IN cord-325712-9kbnyqt3 24 2 the the DT cord-325712-9kbnyqt3 24 3 fusion fusion NN cord-325712-9kbnyqt3 24 4 protein protein NN cord-325712-9kbnyqt3 24 5 is be VBZ cord-325712-9kbnyqt3 24 6 in in IN cord-325712-9kbnyqt3 24 7 a a DT cord-325712-9kbnyqt3 24 8 fusion fusion NN cord-325712-9kbnyqt3 24 9 - - HYPH cord-325712-9kbnyqt3 24 10 competent competent JJ cord-325712-9kbnyqt3 24 11 state state NN cord-325712-9kbnyqt3 24 12 , , , cord-325712-9kbnyqt3 24 13 the the DT cord-325712-9kbnyqt3 24 14 structural structural JJ cord-325712-9kbnyqt3 24 15 The the DT cord-325712-9kbnyqt3 24 16 entry entry NN cord-325712-9kbnyqt3 24 17 process process NN cord-325712-9kbnyqt3 24 18 begins begin VBZ cord-325712-9kbnyqt3 24 19 with with IN cord-325712-9kbnyqt3 24 20 the the DT cord-325712-9kbnyqt3 24 21 virus virus NN cord-325712-9kbnyqt3 24 22 binding bind VBG cord-325712-9kbnyqt3 24 23 to to IN cord-325712-9kbnyqt3 24 24 a a DT cord-325712-9kbnyqt3 24 25 receptor receptor NN cord-325712-9kbnyqt3 24 26 on on IN cord-325712-9kbnyqt3 24 27 the the DT cord-325712-9kbnyqt3 24 28 surface surface NN cord-325712-9kbnyqt3 24 29 of of IN cord-325712-9kbnyqt3 24 30 the the DT cord-325712-9kbnyqt3 24 31 cell cell NN cord-325712-9kbnyqt3 24 32 . . . cord-325712-9kbnyqt3 25 1 This this DT cord-325712-9kbnyqt3 25 2 binding binding NN cord-325712-9kbnyqt3 25 3 may may MD cord-325712-9kbnyqt3 25 4 result result VB cord-325712-9kbnyqt3 25 5 in in IN cord-325712-9kbnyqt3 25 6 ( ( -LRB- cord-325712-9kbnyqt3 25 7 a a DT cord-325712-9kbnyqt3 25 8 ) ) -RRB- cord-325712-9kbnyqt3 25 9 release release NN cord-325712-9kbnyqt3 25 10 of of IN cord-325712-9kbnyqt3 25 11 the the DT cord-325712-9kbnyqt3 25 12 viral viral JJ cord-325712-9kbnyqt3 25 13 genome genome NN cord-325712-9kbnyqt3 25 14 via via IN cord-325712-9kbnyqt3 25 15 fusion fusion NN cord-325712-9kbnyqt3 25 16 at at IN cord-325712-9kbnyqt3 25 17 the the DT cord-325712-9kbnyqt3 25 18 plasma plasma NN cord-325712-9kbnyqt3 25 19 membrane membrane NN cord-325712-9kbnyqt3 25 20 or or CC cord-325712-9kbnyqt3 25 21 ( ( -LRB- cord-325712-9kbnyqt3 25 22 b b NN cord-325712-9kbnyqt3 25 23 ) ) -RRB- cord-325712-9kbnyqt3 25 24 uptake uptake NN cord-325712-9kbnyqt3 25 25 by by IN cord-325712-9kbnyqt3 25 26 endocytosis endocytosis NN cord-325712-9kbnyqt3 25 27 or or CC cord-325712-9kbnyqt3 25 28 macropinocytosis macropinocytosis NN cord-325712-9kbnyqt3 25 29 ( ( -LRB- cord-325712-9kbnyqt3 25 30 not not RB cord-325712-9kbnyqt3 25 31 shown show VBN cord-325712-9kbnyqt3 25 32 ) ) -RRB- cord-325712-9kbnyqt3 25 33 followed follow VBN cord-325712-9kbnyqt3 25 34 by by IN cord-325712-9kbnyqt3 25 35 fusion fusion NN cord-325712-9kbnyqt3 25 36 within within IN cord-325712-9kbnyqt3 25 37 the the DT cord-325712-9kbnyqt3 25 38 endosome endosome NN cord-325712-9kbnyqt3 25 39 . . . cord-325712-9kbnyqt3 26 1 The the DT cord-325712-9kbnyqt3 26 2 location location NN cord-325712-9kbnyqt3 26 3 and and CC cord-325712-9kbnyqt3 26 4 mechanism mechanism NN cord-325712-9kbnyqt3 26 5 of of IN cord-325712-9kbnyqt3 26 6 fusion fusion NN cord-325712-9kbnyqt3 26 7 can can MD cord-325712-9kbnyqt3 26 8 be be VB cord-325712-9kbnyqt3 26 9 impacted impact VBN cord-325712-9kbnyqt3 26 10 by by IN cord-325712-9kbnyqt3 26 11 environmental environmental JJ cord-325712-9kbnyqt3 26 12 conditions condition NNS cord-325712-9kbnyqt3 26 13 , , , cord-325712-9kbnyqt3 26 14 including include VBG cord-325712-9kbnyqt3 26 15 pH ph NN cord-325712-9kbnyqt3 26 16 , , , cord-325712-9kbnyqt3 26 17 ions ion NNS cord-325712-9kbnyqt3 26 18 , , , cord-325712-9kbnyqt3 26 19 protease protease NN cord-325712-9kbnyqt3 26 20 activity activity NN cord-325712-9kbnyqt3 26 21 , , , cord-325712-9kbnyqt3 26 22 and and CC cord-325712-9kbnyqt3 26 23 lipid lipid NN cord-325712-9kbnyqt3 26 24 composition composition NN cord-325712-9kbnyqt3 26 25 . . . cord-325712-9kbnyqt3 27 1 Once once IN cord-325712-9kbnyqt3 27 2 the the DT cord-325712-9kbnyqt3 27 3 genome genome NN cord-325712-9kbnyqt3 27 4 has have VBZ cord-325712-9kbnyqt3 27 5 been be VBN cord-325712-9kbnyqt3 27 6 released release VBN cord-325712-9kbnyqt3 27 7 into into IN cord-325712-9kbnyqt3 27 8 the the DT cord-325712-9kbnyqt3 27 9 cytosol cytosol NN cord-325712-9kbnyqt3 27 10 , , , cord-325712-9kbnyqt3 27 11 it -PRON- PRP cord-325712-9kbnyqt3 27 12 can can MD cord-325712-9kbnyqt3 27 13 access access VB cord-325712-9kbnyqt3 27 14 cellular cellular JJ cord-325712-9kbnyqt3 27 15 machinery machinery NN cord-325712-9kbnyqt3 27 16 , , , cord-325712-9kbnyqt3 27 17 leading lead VBG cord-325712-9kbnyqt3 27 18 to to IN cord-325712-9kbnyqt3 27 19 replication replication NN cord-325712-9kbnyqt3 27 20 of of IN cord-325712-9kbnyqt3 27 21 the the DT cord-325712-9kbnyqt3 27 22 viral viral JJ cord-325712-9kbnyqt3 27 23 genome genome NN cord-325712-9kbnyqt3 27 24 and and CC cord-325712-9kbnyqt3 27 25 synthesis synthesis NN cord-325712-9kbnyqt3 27 26 of of IN cord-325712-9kbnyqt3 27 27 new new JJ cord-325712-9kbnyqt3 27 28 viral viral JJ cord-325712-9kbnyqt3 27 29 proteins protein NNS cord-325712-9kbnyqt3 27 30 . . . cord-325712-9kbnyqt3 28 1 Newly newly RB cord-325712-9kbnyqt3 28 2 synthesized synthesize VBN cord-325712-9kbnyqt3 28 3 virions virion NNS cord-325712-9kbnyqt3 28 4 can can MD cord-325712-9kbnyqt3 28 5 then then RB cord-325712-9kbnyqt3 28 6 exit exit VB cord-325712-9kbnyqt3 28 7 the the DT cord-325712-9kbnyqt3 28 8 cell cell NN cord-325712-9kbnyqt3 28 9 by by IN cord-325712-9kbnyqt3 28 10 budding bud VBG cord-325712-9kbnyqt3 28 11 rearrangement rearrangement NN cord-325712-9kbnyqt3 28 12 necessary necessary JJ cord-325712-9kbnyqt3 28 13 for for IN cord-325712-9kbnyqt3 28 14 exposure exposure NN cord-325712-9kbnyqt3 28 15 of of IN cord-325712-9kbnyqt3 28 16 the the DT cord-325712-9kbnyqt3 28 17 fusion fusion NN cord-325712-9kbnyqt3 28 18 peptide peptide NN cord-325712-9kbnyqt3 28 19 and and CC cord-325712-9kbnyqt3 28 20 its -PRON- PRP$ cord-325712-9kbnyqt3 28 21 burial burial NN cord-325712-9kbnyqt3 28 22 into into IN cord-325712-9kbnyqt3 28 23 the the DT cord-325712-9kbnyqt3 28 24 target target NN cord-325712-9kbnyqt3 28 25 membrane membrane NN cord-325712-9kbnyqt3 28 26 is be VBZ cord-325712-9kbnyqt3 28 27 often often RB cord-325712-9kbnyqt3 28 28 triggered trigger VBN cord-325712-9kbnyqt3 28 29 by by IN cord-325712-9kbnyqt3 28 30 some some DT cord-325712-9kbnyqt3 28 31 change change NN cord-325712-9kbnyqt3 28 32 in in IN cord-325712-9kbnyqt3 28 33 environmental environmental JJ cord-325712-9kbnyqt3 28 34 conditions condition NNS cord-325712-9kbnyqt3 28 35 . . . cord-325712-9kbnyqt3 29 1 Fusion fusion NN cord-325712-9kbnyqt3 29 2 may may MD cord-325712-9kbnyqt3 29 3 be be VB cord-325712-9kbnyqt3 29 4 triggered trigger VBN cord-325712-9kbnyqt3 29 5 by by IN cord-325712-9kbnyqt3 29 6 receptor receptor NN cord-325712-9kbnyqt3 29 7 binding bind VBG cord-325712-9kbnyqt3 29 8 itself -PRON- PRP cord-325712-9kbnyqt3 29 9 , , , cord-325712-9kbnyqt3 29 10 lowering lower VBG cord-325712-9kbnyqt3 29 11 of of IN cord-325712-9kbnyqt3 29 12 pH ph NN cord-325712-9kbnyqt3 29 13 , , , cord-325712-9kbnyqt3 29 14 protease protease NN cord-325712-9kbnyqt3 29 15 action action NN cord-325712-9kbnyqt3 29 16 [ [ -LRB- cord-325712-9kbnyqt3 29 17 6 6 CD cord-325712-9kbnyqt3 29 18 ] ] -RRB- cord-325712-9kbnyqt3 29 19 , , , cord-325712-9kbnyqt3 29 20 or or CC cord-325712-9kbnyqt3 29 21 a a DT cord-325712-9kbnyqt3 29 22 combination combination NN cord-325712-9kbnyqt3 29 23 of of IN cord-325712-9kbnyqt3 29 24 these these DT cord-325712-9kbnyqt3 29 25 [ [ -LRB- cord-325712-9kbnyqt3 29 26 4 4 CD cord-325712-9kbnyqt3 29 27 , , , cord-325712-9kbnyqt3 29 28 7 7 CD cord-325712-9kbnyqt3 29 29 ] ] -RRB- cord-325712-9kbnyqt3 29 30 . . . cord-325712-9kbnyqt3 30 1 Viruses virus NNS cord-325712-9kbnyqt3 30 2 that that WDT cord-325712-9kbnyqt3 30 3 fuse fuse VBP cord-325712-9kbnyqt3 30 4 at at IN cord-325712-9kbnyqt3 30 5 the the DT cord-325712-9kbnyqt3 30 6 plasma plasma NN cord-325712-9kbnyqt3 30 7 membrane membrane NN cord-325712-9kbnyqt3 30 8 may may MD cord-325712-9kbnyqt3 30 9 be be VB cord-325712-9kbnyqt3 30 10 triggered trigger VBN cord-325712-9kbnyqt3 30 11 by by IN cord-325712-9kbnyqt3 30 12 receptor receptor NN cord-325712-9kbnyqt3 30 13 binding binding NN cord-325712-9kbnyqt3 30 14 or or CC cord-325712-9kbnyqt3 30 15 protease protease NN cord-325712-9kbnyqt3 30 16 activation activation NN cord-325712-9kbnyqt3 30 17 , , , cord-325712-9kbnyqt3 30 18 while while IN cord-325712-9kbnyqt3 30 19 those those DT cord-325712-9kbnyqt3 30 20 that that WDT cord-325712-9kbnyqt3 30 21 fuse fuse VBP cord-325712-9kbnyqt3 30 22 within within IN cord-325712-9kbnyqt3 30 23 the the DT cord-325712-9kbnyqt3 30 24 endosome endosome NN cord-325712-9kbnyqt3 30 25 generally generally RB cord-325712-9kbnyqt3 30 26 require require VBP cord-325712-9kbnyqt3 30 27 low low JJ cord-325712-9kbnyqt3 30 28 pH ph NN cord-325712-9kbnyqt3 30 29 and and CC cord-325712-9kbnyqt3 30 30 may may MD cord-325712-9kbnyqt3 30 31 require require VB cord-325712-9kbnyqt3 30 32 other other JJ cord-325712-9kbnyqt3 30 33 additional additional JJ cord-325712-9kbnyqt3 30 34 cues cue NNS cord-325712-9kbnyqt3 30 35 , , , cord-325712-9kbnyqt3 30 36 such such JJ cord-325712-9kbnyqt3 30 37 as as IN cord-325712-9kbnyqt3 30 38 changes change NNS cord-325712-9kbnyqt3 30 39 in in IN cord-325712-9kbnyqt3 30 40 other other JJ cord-325712-9kbnyqt3 30 41 ions ion NNS cord-325712-9kbnyqt3 30 42 than than IN cord-325712-9kbnyqt3 30 43 protons proton NNS cord-325712-9kbnyqt3 30 44 , , , cord-325712-9kbnyqt3 30 45 or or CC cord-325712-9kbnyqt3 30 46 endosome endosome NN cord-325712-9kbnyqt3 30 47 - - HYPH cord-325712-9kbnyqt3 30 48 specific specific JJ cord-325712-9kbnyqt3 30 49 protease protease NN cord-325712-9kbnyqt3 30 50 exposure exposure NN cord-325712-9kbnyqt3 30 51 . . . cord-325712-9kbnyqt3 31 1 Despite despite IN cord-325712-9kbnyqt3 31 2 the the DT cord-325712-9kbnyqt3 31 3 diversity diversity NN cord-325712-9kbnyqt3 31 4 in in IN cord-325712-9kbnyqt3 31 5 structure structure NN cord-325712-9kbnyqt3 31 6 and and CC cord-325712-9kbnyqt3 31 7 triggering trigger VBG cord-325712-9kbnyqt3 31 8 mechanisms mechanism NNS cord-325712-9kbnyqt3 31 9 , , , cord-325712-9kbnyqt3 31 10 fusion fusion NN cord-325712-9kbnyqt3 31 11 proteins protein NNS cord-325712-9kbnyqt3 31 12 typically typically RB cord-325712-9kbnyqt3 31 13 follow follow VBP cord-325712-9kbnyqt3 31 14 a a DT cord-325712-9kbnyqt3 31 15 common common JJ cord-325712-9kbnyqt3 31 16 pathway pathway NN cord-325712-9kbnyqt3 31 17 for for IN cord-325712-9kbnyqt3 31 18 merging merge VBG cord-325712-9kbnyqt3 31 19 the the DT cord-325712-9kbnyqt3 31 20 viral viral JJ cord-325712-9kbnyqt3 31 21 envelope envelope NN cord-325712-9kbnyqt3 31 22 with with IN cord-325712-9kbnyqt3 31 23 the the DT cord-325712-9kbnyqt3 31 24 host host NN cord-325712-9kbnyqt3 31 25 membrane membrane NN cord-325712-9kbnyqt3 31 26 ( ( -LRB- cord-325712-9kbnyqt3 31 27 Fig Fig NNP cord-325712-9kbnyqt3 31 28 . . NNP cord-325712-9kbnyqt3 31 29 2 2 CD cord-325712-9kbnyqt3 31 30 . . . cord-325712-9kbnyqt3 31 31 2 2 LS cord-325712-9kbnyqt3 31 32 ) ) -RRB- cord-325712-9kbnyqt3 31 33 , , , cord-325712-9kbnyqt3 31 34 as as IN cord-325712-9kbnyqt3 31 35 described describe VBN cord-325712-9kbnyqt3 31 36 in in IN cord-325712-9kbnyqt3 31 37 White White NNP cord-325712-9kbnyqt3 31 38 et et NNP cord-325712-9kbnyqt3 31 39 al al NNP cord-325712-9kbnyqt3 31 40 . . . cord-325712-9kbnyqt3 32 1 [ [ -LRB- cord-325712-9kbnyqt3 32 2 5 5 CD cord-325712-9kbnyqt3 32 3 ] ] -RRB- cord-325712-9kbnyqt3 32 4 and and CC cord-325712-9kbnyqt3 32 5 Harrison Harrison NNP cord-325712-9kbnyqt3 32 6 [ [ -LRB- cord-325712-9kbnyqt3 32 7 8 8 CD cord-325712-9kbnyqt3 32 8 ] ] -RRB- cord-325712-9kbnyqt3 32 9 . . . cord-325712-9kbnyqt3 33 1 After after IN cord-325712-9kbnyqt3 33 2 fusion fusion NN cord-325712-9kbnyqt3 33 3 is be VBZ cord-325712-9kbnyqt3 33 4 triggered trigger VBN cord-325712-9kbnyqt3 33 5 , , , cord-325712-9kbnyqt3 33 6 the the DT cord-325712-9kbnyqt3 33 7 protein protein NN cord-325712-9kbnyqt3 33 8 rearranges rearrange VBZ cord-325712-9kbnyqt3 33 9 into into IN cord-325712-9kbnyqt3 33 10 a a DT cord-325712-9kbnyqt3 33 11 prehairpin prehairpin NN cord-325712-9kbnyqt3 33 12 intermediate intermediate NN cord-325712-9kbnyqt3 33 13 ( ( -LRB- cord-325712-9kbnyqt3 33 14 1 1 CD cord-325712-9kbnyqt3 33 15 ) ) -RRB- cord-325712-9kbnyqt3 33 16 with with IN cord-325712-9kbnyqt3 33 17 the the DT cord-325712-9kbnyqt3 33 18 fusion fusion NN cord-325712-9kbnyqt3 33 19 peptide peptide NN cord-325712-9kbnyqt3 33 20 inserted insert VBD cord-325712-9kbnyqt3 33 21 into into IN cord-325712-9kbnyqt3 33 22 the the DT cord-325712-9kbnyqt3 33 23 host host NN cord-325712-9kbnyqt3 33 24 membrane membrane NN cord-325712-9kbnyqt3 33 25 . . . cord-325712-9kbnyqt3 34 1 While while IN cord-325712-9kbnyqt3 34 2 the the DT cord-325712-9kbnyqt3 34 3 fusion fusion NN cord-325712-9kbnyqt3 34 4 protein protein NN cord-325712-9kbnyqt3 34 5 may may MD cord-325712-9kbnyqt3 34 6 be be VB cord-325712-9kbnyqt3 34 7 found find VBN cord-325712-9kbnyqt3 34 8 as as IN cord-325712-9kbnyqt3 34 9 dimers dimer NNS cord-325712-9kbnyqt3 34 10 or or CC cord-325712-9kbnyqt3 34 11 trimers trimer NNS cord-325712-9kbnyqt3 34 12 on on IN cord-325712-9kbnyqt3 34 13 the the DT cord-325712-9kbnyqt3 34 14 surface surface NN cord-325712-9kbnyqt3 34 15 of of IN cord-325712-9kbnyqt3 34 16 the the DT cord-325712-9kbnyqt3 34 17 virus virus NN cord-325712-9kbnyqt3 34 18 ( ( -LRB- cord-325712-9kbnyqt3 34 19 2 2 CD cord-325712-9kbnyqt3 34 20 ) ) -RRB- cord-325712-9kbnyqt3 34 21 , , , cord-325712-9kbnyqt3 34 22 the the DT cord-325712-9kbnyqt3 34 23 prehairpin prehairpin NNP cord-325712-9kbnyqt3 34 24 intermediate intermediate NNP cord-325712-9kbnyqt3 34 25 consists consist VBZ cord-325712-9kbnyqt3 34 26 of of IN cord-325712-9kbnyqt3 34 27 a a DT cord-325712-9kbnyqt3 34 28 trimer trimer NN cord-325712-9kbnyqt3 34 29 . . . cord-325712-9kbnyqt3 35 1 It -PRON- PRP cord-325712-9kbnyqt3 35 2 is be VBZ cord-325712-9kbnyqt3 35 3 thought think VBN cord-325712-9kbnyqt3 35 4 that that IN cord-325712-9kbnyqt3 35 5 several several JJ cord-325712-9kbnyqt3 35 6 prehairpin prehairpin NN cord-325712-9kbnyqt3 35 7 intermediates intermediate NNS cord-325712-9kbnyqt3 35 8 cluster cluster VBP cord-325712-9kbnyqt3 35 9 together together RB cord-325712-9kbnyqt3 35 10 then then RB cord-325712-9kbnyqt3 35 11 fold fold VB cord-325712-9kbnyqt3 35 12 back back RB cord-325712-9kbnyqt3 35 13 on on IN cord-325712-9kbnyqt3 35 14 themselves -PRON- PRP cord-325712-9kbnyqt3 35 15 to to TO cord-325712-9kbnyqt3 35 16 bring bring VB cord-325712-9kbnyqt3 35 17 the the DT cord-325712-9kbnyqt3 35 18 membranes membrane NNS cord-325712-9kbnyqt3 35 19 close close JJ cord-325712-9kbnyqt3 35 20 to to IN cord-325712-9kbnyqt3 35 21 each each DT cord-325712-9kbnyqt3 35 22 other other JJ cord-325712-9kbnyqt3 35 23 ( ( -LRB- cord-325712-9kbnyqt3 35 24 3 3 CD cord-325712-9kbnyqt3 35 25 ) ) -RRB- cord-325712-9kbnyqt3 35 26 . . . cord-325712-9kbnyqt3 36 1 As as IN cord-325712-9kbnyqt3 36 2 the the DT cord-325712-9kbnyqt3 36 3 prehairpins prehairpin NNS cord-325712-9kbnyqt3 36 4 fold fold VBP cord-325712-9kbnyqt3 36 5 into into IN cord-325712-9kbnyqt3 36 6 a a DT cord-325712-9kbnyqt3 36 7 six six CD cord-325712-9kbnyqt3 36 8 - - HYPH cord-325712-9kbnyqt3 36 9 helix helix NN cord-325712-9kbnyqt3 36 10 bundle bundle NN cord-325712-9kbnyqt3 36 11 , , , cord-325712-9kbnyqt3 36 12 the the DT cord-325712-9kbnyqt3 36 13 membranes membrane NNS cord-325712-9kbnyqt3 36 14 are be VBP cord-325712-9kbnyqt3 36 15 brought bring VBN cord-325712-9kbnyqt3 36 16 close close RB cord-325712-9kbnyqt3 36 17 enough enough RB cord-325712-9kbnyqt3 36 18 that that IN cord-325712-9kbnyqt3 36 19 lipids lipid NNS cord-325712-9kbnyqt3 36 20 from from IN cord-325712-9kbnyqt3 36 21 their -PRON- PRP$ cord-325712-9kbnyqt3 36 22 outer outer JJ cord-325712-9kbnyqt3 36 23 leaflets leaflet NNS cord-325712-9kbnyqt3 36 24 are be VBP cord-325712-9kbnyqt3 36 25 able able JJ cord-325712-9kbnyqt3 36 26 to to TO cord-325712-9kbnyqt3 36 27 mix mix VB cord-325712-9kbnyqt3 36 28 , , , cord-325712-9kbnyqt3 36 29 creating create VBG cord-325712-9kbnyqt3 36 30 a a DT cord-325712-9kbnyqt3 36 31 structure structure NN cord-325712-9kbnyqt3 36 32 often often RB cord-325712-9kbnyqt3 36 33 referred refer VBD cord-325712-9kbnyqt3 36 34 to to IN cord-325712-9kbnyqt3 36 35 as as IN cord-325712-9kbnyqt3 36 36 a a DT cord-325712-9kbnyqt3 36 37 " " `` cord-325712-9kbnyqt3 36 38 stalk stalk NN cord-325712-9kbnyqt3 36 39 " " '' cord-325712-9kbnyqt3 36 40 ( ( -LRB- cord-325712-9kbnyqt3 36 41 4 4 CD cord-325712-9kbnyqt3 36 42 ) ) -RRB- cord-325712-9kbnyqt3 36 43 . . . cord-325712-9kbnyqt3 37 1 This this DT cord-325712-9kbnyqt3 37 2 step step NN cord-325712-9kbnyqt3 37 3 is be VBZ cord-325712-9kbnyqt3 37 4 known know VBN cord-325712-9kbnyqt3 37 5 as as IN cord-325712-9kbnyqt3 37 6 hemifusion hemifusion NN cord-325712-9kbnyqt3 37 7 . . . cord-325712-9kbnyqt3 38 1 Lastly lastly RB cord-325712-9kbnyqt3 38 2 , , , cord-325712-9kbnyqt3 38 3 a a DT cord-325712-9kbnyqt3 38 4 pore pore NN cord-325712-9kbnyqt3 38 5 forms form NNS cord-325712-9kbnyqt3 38 6 ( ( -LRB- cord-325712-9kbnyqt3 38 7 5 5 LS cord-325712-9kbnyqt3 38 8 ) ) -RRB- cord-325712-9kbnyqt3 38 9 enabling enable VBG cord-325712-9kbnyqt3 38 10 the the DT cord-325712-9kbnyqt3 38 11 viral viral JJ cord-325712-9kbnyqt3 38 12 genome genome NN cord-325712-9kbnyqt3 38 13 to to TO cord-325712-9kbnyqt3 38 14 pass pass VB cord-325712-9kbnyqt3 38 15 through through IN cord-325712-9kbnyqt3 38 16 this this DT cord-325712-9kbnyqt3 38 17 opening opening NN cord-325712-9kbnyqt3 38 18 as as IN cord-325712-9kbnyqt3 38 19 the the DT cord-325712-9kbnyqt3 38 20 fusion fusion NN cord-325712-9kbnyqt3 38 21 proteins protein NNS cord-325712-9kbnyqt3 38 22 form form VBP cord-325712-9kbnyqt3 38 23 into into IN cord-325712-9kbnyqt3 38 24 a a DT cord-325712-9kbnyqt3 38 25 stable stable JJ cord-325712-9kbnyqt3 38 26 trimer trimer NN cord-325712-9kbnyqt3 38 27 of of IN cord-325712-9kbnyqt3 38 28 hairpins hairpin NNS cord-325712-9kbnyqt3 38 29 . . . cord-325712-9kbnyqt3 39 1 Although although IN cord-325712-9kbnyqt3 39 2 all all DT cord-325712-9kbnyqt3 39 3 viral viral JJ cord-325712-9kbnyqt3 39 4 fusion fusion NN cord-325712-9kbnyqt3 39 5 proteins protein NNS cord-325712-9kbnyqt3 39 6 studied study VBD cord-325712-9kbnyqt3 39 7 to to IN cord-325712-9kbnyqt3 39 8 date date NN cord-325712-9kbnyqt3 39 9 follow follow VB cord-325712-9kbnyqt3 39 10 this this DT cord-325712-9kbnyqt3 39 11 common common JJ cord-325712-9kbnyqt3 39 12 pathway pathway NN cord-325712-9kbnyqt3 39 13 , , , cord-325712-9kbnyqt3 39 14 much much JJ cord-325712-9kbnyqt3 39 15 remains remain VBZ cord-325712-9kbnyqt3 39 16 unknown unknown JJ cord-325712-9kbnyqt3 39 17 about about IN cord-325712-9kbnyqt3 39 18 viral viral JJ cord-325712-9kbnyqt3 39 19 entry entry NN cord-325712-9kbnyqt3 39 20 itself -PRON- PRP cord-325712-9kbnyqt3 39 21 . . . cord-325712-9kbnyqt3 40 1 For for IN cord-325712-9kbnyqt3 40 2 example example NN cord-325712-9kbnyqt3 40 3 , , , cord-325712-9kbnyqt3 40 4 the the DT cord-325712-9kbnyqt3 40 5 dynamics dynamic NNS cord-325712-9kbnyqt3 40 6 of of IN cord-325712-9kbnyqt3 40 7 these these DT cord-325712-9kbnyqt3 40 8 fusion fusion NN cord-325712-9kbnyqt3 40 9 steps step NNS cord-325712-9kbnyqt3 40 10 are be VBP cord-325712-9kbnyqt3 40 11 not not RB cord-325712-9kbnyqt3 40 12 fully fully RB cord-325712-9kbnyqt3 40 13 understood understand VBN cord-325712-9kbnyqt3 40 14 , , , cord-325712-9kbnyqt3 40 15 the the DT cord-325712-9kbnyqt3 40 16 fusion fusion NN cord-325712-9kbnyqt3 40 17 trigger trigger NN cord-325712-9kbnyqt3 40 18 of of IN cord-325712-9kbnyqt3 40 19 some some DT cord-325712-9kbnyqt3 40 20 viruses virus NNS cord-325712-9kbnyqt3 40 21 remains remain VBZ cord-325712-9kbnyqt3 40 22 ambiguous ambiguous JJ cord-325712-9kbnyqt3 40 23 , , , cord-325712-9kbnyqt3 40 24 and and CC cord-325712-9kbnyqt3 40 25 developing develop VBG cord-325712-9kbnyqt3 40 26 antivirals antiviral NNS cord-325712-9kbnyqt3 40 27 to to TO cord-325712-9kbnyqt3 40 28 halt halt VB cord-325712-9kbnyqt3 40 29 virus virus NN cord-325712-9kbnyqt3 40 30 entry entry NN cord-325712-9kbnyqt3 40 31 requires require VBZ cord-325712-9kbnyqt3 40 32 further further JJ cord-325712-9kbnyqt3 40 33 characterization characterization NN cord-325712-9kbnyqt3 40 34 of of IN cord-325712-9kbnyqt3 40 35 all all DT cord-325712-9kbnyqt3 40 36 of of IN cord-325712-9kbnyqt3 40 37 the the DT cord-325712-9kbnyqt3 40 38 steps step NNS cord-325712-9kbnyqt3 40 39 between between IN cord-325712-9kbnyqt3 40 40 initial initial JJ cord-325712-9kbnyqt3 40 41 viral viral JJ cord-325712-9kbnyqt3 40 42 contact contact NN cord-325712-9kbnyqt3 40 43 with with IN cord-325712-9kbnyqt3 40 44 the the DT cord-325712-9kbnyqt3 40 45 host host NN cord-325712-9kbnyqt3 40 46 cell cell NN cord-325712-9kbnyqt3 40 47 and and CC cord-325712-9kbnyqt3 40 48 viral viral JJ cord-325712-9kbnyqt3 40 49 genome genome NN cord-325712-9kbnyqt3 40 50 release release NN cord-325712-9kbnyqt3 40 51 . . . cord-325712-9kbnyqt3 41 1 Techniques technique NNS cord-325712-9kbnyqt3 41 2 for for IN cord-325712-9kbnyqt3 41 3 studying study VBG cord-325712-9kbnyqt3 41 4 virus virus NN cord-325712-9kbnyqt3 41 5 entry entry NN cord-325712-9kbnyqt3 41 6 can can MD cord-325712-9kbnyqt3 41 7 be be VB cord-325712-9kbnyqt3 41 8 broadly broadly RB cord-325712-9kbnyqt3 41 9 classified classify VBN cord-325712-9kbnyqt3 41 10 as as IN cord-325712-9kbnyqt3 41 11 those those DT cord-325712-9kbnyqt3 41 12 that that WDT cord-325712-9kbnyqt3 41 13 examine examine VBP cord-325712-9kbnyqt3 41 14 the the DT cord-325712-9kbnyqt3 41 15 entry entry NN cord-325712-9kbnyqt3 41 16 of of IN cord-325712-9kbnyqt3 41 17 a a DT cord-325712-9kbnyqt3 41 18 collective collective JJ cord-325712-9kbnyqt3 41 19 group group NN cord-325712-9kbnyqt3 41 20 or or CC cord-325712-9kbnyqt3 41 21 ensemble ensemble NN cord-325712-9kbnyqt3 41 22 of of IN cord-325712-9kbnyqt3 41 23 virions virion NNS cord-325712-9kbnyqt3 41 24 and and CC cord-325712-9kbnyqt3 41 25 those those DT cord-325712-9kbnyqt3 41 26 that that WDT cord-325712-9kbnyqt3 41 27 track track VBP cord-325712-9kbnyqt3 41 28 individual individual JJ cord-325712-9kbnyqt3 41 29 virion virion NN cord-325712-9kbnyqt3 41 30 entry entry NN cord-325712-9kbnyqt3 41 31 . . . cord-325712-9kbnyqt3 42 1 Ensemble ensemble NN cord-325712-9kbnyqt3 42 2 methods method NNS cord-325712-9kbnyqt3 42 3 provide provide VBP cord-325712-9kbnyqt3 42 4 information information NN cord-325712-9kbnyqt3 42 5 on on IN cord-325712-9kbnyqt3 42 6 the the DT cord-325712-9kbnyqt3 42 7 broader broad JJR cord-325712-9kbnyqt3 42 8 context context NN cord-325712-9kbnyqt3 42 9 of of IN cord-325712-9kbnyqt3 42 10 entry entry NN cord-325712-9kbnyqt3 42 11 steps step NNS cord-325712-9kbnyqt3 42 12 , , , cord-325712-9kbnyqt3 42 13 while while IN cord-325712-9kbnyqt3 42 14 single single JJ cord-325712-9kbnyqt3 42 15 virion virion NN cord-325712-9kbnyqt3 42 16 imaging imaging NN cord-325712-9kbnyqt3 42 17 provides provide VBZ cord-325712-9kbnyqt3 42 18 detailed detailed JJ cord-325712-9kbnyqt3 42 19 information information NN cord-325712-9kbnyqt3 42 20 on on IN cord-325712-9kbnyqt3 42 21 the the DT cord-325712-9kbnyqt3 42 22 dynamics dynamic NNS cord-325712-9kbnyqt3 42 23 of of IN cord-325712-9kbnyqt3 42 24 those those DT cord-325712-9kbnyqt3 42 25 steps step NNS cord-325712-9kbnyqt3 42 26 . . . cord-325712-9kbnyqt3 43 1 Ensemble ensemble NN cord-325712-9kbnyqt3 43 2 methods method NNS cord-325712-9kbnyqt3 43 3 include include VBP cord-325712-9kbnyqt3 43 4 many many JJ cord-325712-9kbnyqt3 43 5 of of IN cord-325712-9kbnyqt3 43 6 the the DT cord-325712-9kbnyqt3 43 7 most most RBS cord-325712-9kbnyqt3 43 8 wellestablished wellestablished JJ cord-325712-9kbnyqt3 43 9 techniques technique NNS cord-325712-9kbnyqt3 43 10 for for IN cord-325712-9kbnyqt3 43 11 studying study VBG cord-325712-9kbnyqt3 43 12 viral viral JJ cord-325712-9kbnyqt3 43 13 entry entry NN cord-325712-9kbnyqt3 43 14 and and CC cord-325712-9kbnyqt3 43 15 may may MD cord-325712-9kbnyqt3 43 16 probe probe VB cord-325712-9kbnyqt3 43 17 overall overall JJ cord-325712-9kbnyqt3 43 18 infection infection NN cord-325712-9kbnyqt3 43 19 , , , cord-325712-9kbnyqt3 43 20 receptor receptor NN cord-325712-9kbnyqt3 43 21 binding binding NN cord-325712-9kbnyqt3 43 22 , , , cord-325712-9kbnyqt3 43 23 fusion fusion NN cord-325712-9kbnyqt3 43 24 , , , cord-325712-9kbnyqt3 43 25 or or CC cord-325712-9kbnyqt3 43 26 cargo cargo NN cord-325712-9kbnyqt3 43 27 transfer transfer NN cord-325712-9kbnyqt3 43 28 . . . cord-325712-9kbnyqt3 44 1 Single single JJ cord-325712-9kbnyqt3 44 2 virion virion NN cord-325712-9kbnyqt3 44 3 imaging imaging NN cord-325712-9kbnyqt3 44 4 techniques technique NNS cord-325712-9kbnyqt3 44 5 can can MD cord-325712-9kbnyqt3 44 6 provide provide VB cord-325712-9kbnyqt3 44 7 mechanistic mechanistic JJ cord-325712-9kbnyqt3 44 8 detail detail NN cord-325712-9kbnyqt3 44 9 and and CC cord-325712-9kbnyqt3 44 10 kinetics kinetic NNS cord-325712-9kbnyqt3 44 11 for for IN cord-325712-9kbnyqt3 44 12 steps step NNS cord-325712-9kbnyqt3 44 13 that that WDT cord-325712-9kbnyqt3 44 14 are be VBP cord-325712-9kbnyqt3 44 15 masked mask VBN cord-325712-9kbnyqt3 44 16 in in IN cord-325712-9kbnyqt3 44 17 ensemble ensemble JJ cord-325712-9kbnyqt3 44 18 methods method NNS cord-325712-9kbnyqt3 44 19 . . . cord-325712-9kbnyqt3 45 1 In in IN cord-325712-9kbnyqt3 45 2 addition addition NN cord-325712-9kbnyqt3 45 3 , , , cord-325712-9kbnyqt3 45 4 for for IN cord-325712-9kbnyqt3 45 5 HIV HIV NNP cord-325712-9kbnyqt3 45 6 [ [ -LRB- cord-325712-9kbnyqt3 45 7 9 9 CD cord-325712-9kbnyqt3 45 8 ] ] -RRB- cord-325712-9kbnyqt3 45 9 , , , cord-325712-9kbnyqt3 45 10 influenza influenza NN cord-325712-9kbnyqt3 45 11 [ [ -LRB- cord-325712-9kbnyqt3 45 12 10 10 CD cord-325712-9kbnyqt3 45 13 ] ] -RRB- cord-325712-9kbnyqt3 45 14 , , , cord-325712-9kbnyqt3 45 15 and and CC cord-325712-9kbnyqt3 45 16 Ebola Ebola NNP cord-325712-9kbnyqt3 45 17 virus virus NN cord-325712-9kbnyqt3 45 18 [ [ -LRB- cord-325712-9kbnyqt3 45 19 11 11 CD cord-325712-9kbnyqt3 45 20 ] ] -RRB- cord-325712-9kbnyqt3 45 21 , , , cord-325712-9kbnyqt3 45 22 most most JJS cord-325712-9kbnyqt3 45 23 virions virion NNS cord-325712-9kbnyqt3 45 24 that that WDT cord-325712-9kbnyqt3 45 25 encounter encounter VBP cord-325712-9kbnyqt3 45 26 a a DT cord-325712-9kbnyqt3 45 27 cell cell NN cord-325712-9kbnyqt3 45 28 are be VBP cord-325712-9kbnyqt3 45 29 not not RB cord-325712-9kbnyqt3 45 30 involved involve VBN cord-325712-9kbnyqt3 45 31 in in IN cord-325712-9kbnyqt3 45 32 productive productive JJ cord-325712-9kbnyqt3 45 33 entry entry NN cord-325712-9kbnyqt3 45 34 so so IN cord-325712-9kbnyqt3 45 35 the the DT cord-325712-9kbnyqt3 45 36 ability ability NN cord-325712-9kbnyqt3 45 37 of of IN cord-325712-9kbnyqt3 45 38 single single JJ cord-325712-9kbnyqt3 45 39 virion virion NN cord-325712-9kbnyqt3 45 40 techniques technique NNS cord-325712-9kbnyqt3 45 41 to to TO cord-325712-9kbnyqt3 45 42 distinguish distinguish VB cord-325712-9kbnyqt3 45 43 entry entry NN cord-325712-9kbnyqt3 45 44 - - HYPH cord-325712-9kbnyqt3 45 45 competent competent JJ cord-325712-9kbnyqt3 45 46 particles particle NNS cord-325712-9kbnyqt3 45 47 from from IN cord-325712-9kbnyqt3 45 48 non non JJ cord-325712-9kbnyqt3 45 49 - - JJ cord-325712-9kbnyqt3 45 50 competent competent JJ cord-325712-9kbnyqt3 45 51 ones one NNS cord-325712-9kbnyqt3 45 52 and and CC cord-325712-9kbnyqt3 45 53 characterize characterize VB cord-325712-9kbnyqt3 45 54 their -PRON- PRP$ cord-325712-9kbnyqt3 45 55 individual individual JJ cord-325712-9kbnyqt3 45 56 behavior behavior NN cord-325712-9kbnyqt3 45 57 provides provide VBZ cord-325712-9kbnyqt3 45 58 valuable valuable JJ cord-325712-9kbnyqt3 45 59 data datum NNS cord-325712-9kbnyqt3 45 60 on on IN cord-325712-9kbnyqt3 45 61 heterogeneity heterogeneity NN cord-325712-9kbnyqt3 45 62 in in IN cord-325712-9kbnyqt3 45 63 viral viral JJ cord-325712-9kbnyqt3 45 64 populations population NNS cord-325712-9kbnyqt3 45 65 and and CC cord-325712-9kbnyqt3 45 66 its -PRON- PRP$ cord-325712-9kbnyqt3 45 67 ultimate ultimate JJ cord-325712-9kbnyqt3 45 68 impact impact NN cord-325712-9kbnyqt3 45 69 on on IN cord-325712-9kbnyqt3 45 70 infection infection NN cord-325712-9kbnyqt3 45 71 . . . cord-325712-9kbnyqt3 46 1 The the DT cord-325712-9kbnyqt3 46 2 remaining remain VBG cord-325712-9kbnyqt3 46 3 part part NN cord-325712-9kbnyqt3 46 4 of of IN cord-325712-9kbnyqt3 46 5 the the DT cord-325712-9kbnyqt3 46 6 chapter chapter NN cord-325712-9kbnyqt3 46 7 will will MD cord-325712-9kbnyqt3 46 8 focus focus VB cord-325712-9kbnyqt3 46 9 on on IN cord-325712-9kbnyqt3 46 10 single single JJ cord-325712-9kbnyqt3 46 11 particle particle NN cord-325712-9kbnyqt3 46 12 tracking tracking NN cord-325712-9kbnyqt3 46 13 microscopy microscopy NN cord-325712-9kbnyqt3 46 14 techniques technique NNS cord-325712-9kbnyqt3 46 15 compatible compatible JJ cord-325712-9kbnyqt3 46 16 with with IN cord-325712-9kbnyqt3 46 17 dynamic dynamic JJ cord-325712-9kbnyqt3 46 18 / / SYM cord-325712-9kbnyqt3 46 19 temporal temporal JJ cord-325712-9kbnyqt3 46 20 data datum NNS cord-325712-9kbnyqt3 46 21 acquisition acquisition NN cord-325712-9kbnyqt3 46 22 , , , cord-325712-9kbnyqt3 46 23 their -PRON- PRP$ cord-325712-9kbnyqt3 46 24 salient salient JJ cord-325712-9kbnyqt3 46 25 features feature NNS cord-325712-9kbnyqt3 46 26 , , , cord-325712-9kbnyqt3 46 27 and and CC cord-325712-9kbnyqt3 46 28 how how WRB cord-325712-9kbnyqt3 46 29 the the DT cord-325712-9kbnyqt3 46 30 data datum NNS cord-325712-9kbnyqt3 46 31 generated generate VBN cord-325712-9kbnyqt3 46 32 complement complement NN cord-325712-9kbnyqt3 46 33 ensemble ensemble JJ cord-325712-9kbnyqt3 46 34 methods method NNS cord-325712-9kbnyqt3 46 35 for for IN cord-325712-9kbnyqt3 46 36 studying study VBG cord-325712-9kbnyqt3 46 37 viral viral JJ cord-325712-9kbnyqt3 46 38 entry entry NN cord-325712-9kbnyqt3 46 39 processes process NNS cord-325712-9kbnyqt3 46 40 and and CC cord-325712-9kbnyqt3 46 41 their -PRON- PRP$ cord-325712-9kbnyqt3 46 42 intermediate intermediate JJ cord-325712-9kbnyqt3 46 43 steps step NNS cord-325712-9kbnyqt3 46 44 and and CC cord-325712-9kbnyqt3 46 45 mechanisms mechanism NNS cord-325712-9kbnyqt3 46 46 . . . cord-325712-9kbnyqt3 47 1 Over over IN cord-325712-9kbnyqt3 47 2 the the DT cord-325712-9kbnyqt3 47 3 past past JJ cord-325712-9kbnyqt3 47 4 30 30 CD cord-325712-9kbnyqt3 47 5 years year NNS cord-325712-9kbnyqt3 47 6 , , , cord-325712-9kbnyqt3 47 7 microscopy microscopy NN cord-325712-9kbnyqt3 47 8 optics optic NNS cord-325712-9kbnyqt3 47 9 , , , cord-325712-9kbnyqt3 47 10 fluorescent fluorescent JJ cord-325712-9kbnyqt3 47 11 labeling labeling NN cord-325712-9kbnyqt3 47 12 strategies strategy NNS cord-325712-9kbnyqt3 47 13 , , , cord-325712-9kbnyqt3 47 14 computing compute VBG cord-325712-9kbnyqt3 47 15 power power NN cord-325712-9kbnyqt3 47 16 and and CC cord-325712-9kbnyqt3 47 17 image image NN cord-325712-9kbnyqt3 47 18 processing processing NN cord-325712-9kbnyqt3 47 19 have have VBP cord-325712-9kbnyqt3 47 20 enabled enable VBN cord-325712-9kbnyqt3 47 21 the the DT cord-325712-9kbnyqt3 47 22 dynamic dynamic JJ cord-325712-9kbnyqt3 47 23 tracking tracking NN cord-325712-9kbnyqt3 47 24 of of IN cord-325712-9kbnyqt3 47 25 individual individual JJ cord-325712-9kbnyqt3 47 26 virions virion NNS cord-325712-9kbnyqt3 47 27 throughout throughout IN cord-325712-9kbnyqt3 47 28 the the DT cord-325712-9kbnyqt3 47 29 entry entry NN cord-325712-9kbnyqt3 47 30 process process NN cord-325712-9kbnyqt3 47 31 and and CC cord-325712-9kbnyqt3 47 32 the the DT cord-325712-9kbnyqt3 47 33 decomposition decomposition NN cord-325712-9kbnyqt3 47 34 of of IN cord-325712-9kbnyqt3 47 35 their -PRON- PRP$ cord-325712-9kbnyqt3 47 36 intermediate intermediate JJ cord-325712-9kbnyqt3 47 37 steps step NNS cord-325712-9kbnyqt3 47 38 . . . cord-325712-9kbnyqt3 48 1 For for IN cord-325712-9kbnyqt3 48 2 some some DT cord-325712-9kbnyqt3 48 3 examples example NNS cord-325712-9kbnyqt3 48 4 , , , cord-325712-9kbnyqt3 48 5 see see VB cord-325712-9kbnyqt3 48 6 the the DT cord-325712-9kbnyqt3 48 7 following follow VBG cord-325712-9kbnyqt3 48 8 references reference NNS cord-325712-9kbnyqt3 48 9 : : : cord-325712-9kbnyqt3 48 10 [ [ -LRB- cord-325712-9kbnyqt3 48 11 12 12 CD cord-325712-9kbnyqt3 48 12 ] ] -RRB- cord-325712-9kbnyqt3 48 13 [ [ -LRB- cord-325712-9kbnyqt3 48 14 13 13 CD cord-325712-9kbnyqt3 48 15 ] ] -RRB- cord-325712-9kbnyqt3 48 16 [ [ -LRB- cord-325712-9kbnyqt3 48 17 14 14 CD cord-325712-9kbnyqt3 48 18 ] ] -RRB- cord-325712-9kbnyqt3 48 19 [ [ -LRB- cord-325712-9kbnyqt3 48 20 15 15 CD cord-325712-9kbnyqt3 48 21 ] ] -RRB- cord-325712-9kbnyqt3 48 22 [ [ -LRB- cord-325712-9kbnyqt3 48 23 16 16 CD cord-325712-9kbnyqt3 48 24 ] ] -RRB- cord-325712-9kbnyqt3 48 25 [ [ -LRB- cord-325712-9kbnyqt3 48 26 17 17 CD cord-325712-9kbnyqt3 48 27 ] ] -RRB- cord-325712-9kbnyqt3 48 28 [ [ -LRB- cord-325712-9kbnyqt3 48 29 18 18 CD cord-325712-9kbnyqt3 48 30 ] ] -RRB- cord-325712-9kbnyqt3 48 31 . . . cord-325712-9kbnyqt3 49 1 In in IN cord-325712-9kbnyqt3 49 2 particular particular JJ cord-325712-9kbnyqt3 49 3 , , , cord-325712-9kbnyqt3 49 4 charge charge NN cord-325712-9kbnyqt3 49 5 coupled coupled JJ cord-325712-9kbnyqt3 49 6 device device NN cord-325712-9kbnyqt3 49 7 ( ( -LRB- cord-325712-9kbnyqt3 49 8 CCD CCD NNP cord-325712-9kbnyqt3 49 9 ) ) -RRB- cord-325712-9kbnyqt3 49 10 cameras camera NNS cord-325712-9kbnyqt3 49 11 combined combine VBN cord-325712-9kbnyqt3 49 12 with with IN cord-325712-9kbnyqt3 49 13 advanced advanced JJ cord-325712-9kbnyqt3 49 14 microscopy microscopy NNS cord-325712-9kbnyqt3 49 15 enable enable VBP cord-325712-9kbnyqt3 49 16 single single JJ cord-325712-9kbnyqt3 49 17 particle particle NN cord-325712-9kbnyqt3 49 18 resolution resolution NN cord-325712-9kbnyqt3 49 19 [ [ -LRB- cord-325712-9kbnyqt3 49 20 19 19 CD cord-325712-9kbnyqt3 49 21 ] ] -RRB- cord-325712-9kbnyqt3 49 22 . . . cord-325712-9kbnyqt3 50 1 The the DT cord-325712-9kbnyqt3 50 2 frame frame NN cord-325712-9kbnyqt3 50 3 rates rate NNS cord-325712-9kbnyqt3 50 4 of of IN cord-325712-9kbnyqt3 50 5 today today NN cord-325712-9kbnyqt3 50 6 's 's POS cord-325712-9kbnyqt3 50 7 cameras camera NNS cord-325712-9kbnyqt3 50 8 dictate dictate VBP cord-325712-9kbnyqt3 50 9 temporal temporal JJ cord-325712-9kbnyqt3 50 10 resolution resolution NN cord-325712-9kbnyqt3 50 11 of of IN cord-325712-9kbnyqt3 50 12 dynamic dynamic JJ cord-325712-9kbnyqt3 50 13 studies study NNS cord-325712-9kbnyqt3 50 14 , , , cord-325712-9kbnyqt3 50 15 which which WDT cord-325712-9kbnyqt3 50 16 can can MD cord-325712-9kbnyqt3 50 17 range range VB cord-325712-9kbnyqt3 50 18 from from IN cord-325712-9kbnyqt3 50 19 a a DT cord-325712-9kbnyqt3 50 20 few few JJ cord-325712-9kbnyqt3 50 21 to to IN cord-325712-9kbnyqt3 50 22 hundreds hundred NNS cord-325712-9kbnyqt3 50 23 of of IN cord-325712-9kbnyqt3 50 24 milliseconds millisecond NNS cord-325712-9kbnyqt3 50 25 [ [ -LRB- cord-325712-9kbnyqt3 50 26 20 20 CD cord-325712-9kbnyqt3 50 27 , , , cord-325712-9kbnyqt3 50 28 21 21 CD cord-325712-9kbnyqt3 50 29 ] ] -RRB- cord-325712-9kbnyqt3 50 30 . . . cord-325712-9kbnyqt3 51 1 In in IN cord-325712-9kbnyqt3 51 2 the the DT cord-325712-9kbnyqt3 51 3 following follow VBG cord-325712-9kbnyqt3 51 4 sections section NNS cord-325712-9kbnyqt3 51 5 , , , cord-325712-9kbnyqt3 51 6 the the DT cord-325712-9kbnyqt3 51 7 main main JJ cord-325712-9kbnyqt3 51 8 advances advance NNS cord-325712-9kbnyqt3 51 9 enabling enable VBG cord-325712-9kbnyqt3 51 10 single single JJ cord-325712-9kbnyqt3 51 11 virion virion NN cord-325712-9kbnyqt3 51 12 tracking tracking NN cord-325712-9kbnyqt3 51 13 techniques technique NNS cord-325712-9kbnyqt3 51 14 are be VBP cord-325712-9kbnyqt3 51 15 summarized summarize VBN cord-325712-9kbnyqt3 51 16 . . . cord-325712-9kbnyqt3 52 1 Three three CD cord-325712-9kbnyqt3 52 2 microscopy microscopy NN cord-325712-9kbnyqt3 52 3 configurations configuration NNS cord-325712-9kbnyqt3 52 4 are be VBP cord-325712-9kbnyqt3 52 5 commonly commonly RB cord-325712-9kbnyqt3 52 6 employed employ VBN cord-325712-9kbnyqt3 52 7 in in IN cord-325712-9kbnyqt3 52 8 virology virology NN cord-325712-9kbnyqt3 52 9 research research NN cord-325712-9kbnyqt3 52 10 : : : cord-325712-9kbnyqt3 52 11 epifluorescence epifluorescence NNP cord-325712-9kbnyqt3 52 12 , , , cord-325712-9kbnyqt3 52 13 total total JJ cord-325712-9kbnyqt3 52 14 internal internal JJ cord-325712-9kbnyqt3 52 15 reflection reflection NN cord-325712-9kbnyqt3 52 16 fluorescence fluorescence NN cord-325712-9kbnyqt3 52 17 ( ( -LRB- cord-325712-9kbnyqt3 52 18 TIRF TIRF NNP cord-325712-9kbnyqt3 52 19 ) ) -RRB- cord-325712-9kbnyqt3 52 20 , , , cord-325712-9kbnyqt3 52 21 and and CC cord-325712-9kbnyqt3 52 22 confocal confocal JJ cord-325712-9kbnyqt3 52 23 microscopy microscopy NNS cord-325712-9kbnyqt3 52 24 [ [ -LRB- cord-325712-9kbnyqt3 52 25 22 22 CD cord-325712-9kbnyqt3 52 26 , , , cord-325712-9kbnyqt3 52 27 23 23 CD cord-325712-9kbnyqt3 52 28 ] ] -RRB- cord-325712-9kbnyqt3 52 29 as as IN cord-325712-9kbnyqt3 52 30 illustrated illustrate VBN cord-325712-9kbnyqt3 52 31 in in IN cord-325712-9kbnyqt3 52 32 Fig Fig NNP cord-325712-9kbnyqt3 52 33 . . NNP cord-325712-9kbnyqt3 52 34 2 2 CD cord-325712-9kbnyqt3 52 35 . . . cord-325712-9kbnyqt3 53 1 3 3 LS cord-325712-9kbnyqt3 53 2 . . . cord-325712-9kbnyqt3 54 1 The the DT cord-325712-9kbnyqt3 54 2 epifluorescence epifluorescence NN cord-325712-9kbnyqt3 54 3 configuration configuration NN cord-325712-9kbnyqt3 54 4 ( ( -LRB- cord-325712-9kbnyqt3 54 5 Fig fig NN cord-325712-9kbnyqt3 54 6 . . . cord-325712-9kbnyqt3 55 1 2 2 LS cord-325712-9kbnyqt3 55 2 .3a .3a CD cord-325712-9kbnyqt3 55 3 , , , cord-325712-9kbnyqt3 55 4 d d LS cord-325712-9kbnyqt3 55 5 ) ) -RRB- cord-325712-9kbnyqt3 55 6 illuminates illuminate VBZ cord-325712-9kbnyqt3 55 7 everything everything NN cord-325712-9kbnyqt3 55 8 within within IN cord-325712-9kbnyqt3 55 9 the the DT cord-325712-9kbnyqt3 55 10 field field NN cord-325712-9kbnyqt3 55 11 of of IN cord-325712-9kbnyqt3 55 12 view view NN cord-325712-9kbnyqt3 55 13 . . . cord-325712-9kbnyqt3 56 1 So so RB cord-325712-9kbnyqt3 56 2 , , , cord-325712-9kbnyqt3 56 3 unbound unbound JJ cord-325712-9kbnyqt3 56 4 virions virion NNS cord-325712-9kbnyqt3 56 5 in in IN cord-325712-9kbnyqt3 56 6 the the DT cord-325712-9kbnyqt3 56 7 bulk bulk JJ cord-325712-9kbnyqt3 56 8 phase phase NN cord-325712-9kbnyqt3 56 9 or or CC cord-325712-9kbnyqt3 56 10 cells cell NNS cord-325712-9kbnyqt3 56 11 with with IN cord-325712-9kbnyqt3 56 12 high high JJ cord-325712-9kbnyqt3 56 13 background background NN cord-325712-9kbnyqt3 56 14 autofluorescence autofluorescence NN cord-325712-9kbnyqt3 56 15 result result VBP cord-325712-9kbnyqt3 56 16 in in IN cord-325712-9kbnyqt3 56 17 high high JJ cord-325712-9kbnyqt3 56 18 noise noise NN cord-325712-9kbnyqt3 56 19 that that WDT cord-325712-9kbnyqt3 56 20 obscures obscure VBZ cord-325712-9kbnyqt3 56 21 signals signal NNS cord-325712-9kbnyqt3 56 22 from from IN cord-325712-9kbnyqt3 56 23 individual individual JJ cord-325712-9kbnyqt3 56 24 virions virion NNS cord-325712-9kbnyqt3 56 25 . . . cord-325712-9kbnyqt3 57 1 As as IN cord-325712-9kbnyqt3 57 2 a a DT cord-325712-9kbnyqt3 57 3 result result NN cord-325712-9kbnyqt3 57 4 , , , cord-325712-9kbnyqt3 57 5 epifluorescence epifluorescence NN cord-325712-9kbnyqt3 57 6 is be VBZ cord-325712-9kbnyqt3 57 7 not not RB cord-325712-9kbnyqt3 57 8 typically typically RB cord-325712-9kbnyqt3 57 9 used use VBN cord-325712-9kbnyqt3 57 10 for for IN cord-325712-9kbnyqt3 57 11 single single JJ cord-325712-9kbnyqt3 57 12 virion virion NN cord-325712-9kbnyqt3 57 13 tracking tracking NN cord-325712-9kbnyqt3 57 14 . . . cord-325712-9kbnyqt3 58 1 In in IN cord-325712-9kbnyqt3 58 2 the the DT cord-325712-9kbnyqt3 58 3 TIRF TIRF NNP cord-325712-9kbnyqt3 58 4 configuration configuration NN cord-325712-9kbnyqt3 58 5 ( ( -LRB- cord-325712-9kbnyqt3 58 6 Fig Fig NNP cord-325712-9kbnyqt3 58 7 . . NNP cord-325712-9kbnyqt3 58 8 2 2 CD cord-325712-9kbnyqt3 58 9 . . . cord-325712-9kbnyqt3 58 10 3b 3b NNP cord-325712-9kbnyqt3 58 11 , , , cord-325712-9kbnyqt3 58 12 e e LS cord-325712-9kbnyqt3 58 13 ) ) -RRB- cord-325712-9kbnyqt3 58 14 , , , cord-325712-9kbnyqt3 58 15 only only RB cord-325712-9kbnyqt3 58 16 particles particle NNS cord-325712-9kbnyqt3 58 17 within within IN cord-325712-9kbnyqt3 58 18 a a DT cord-325712-9kbnyqt3 58 19 shallow shallow JJ cord-325712-9kbnyqt3 58 20 field field NN cord-325712-9kbnyqt3 58 21 are be VBP cord-325712-9kbnyqt3 58 22 illuminated illuminate VBN cord-325712-9kbnyqt3 58 23 , , , cord-325712-9kbnyqt3 58 24 eliminating eliminate VBG cord-325712-9kbnyqt3 58 25 noise noise NN cord-325712-9kbnyqt3 58 26 from from IN cord-325712-9kbnyqt3 58 27 the the DT cord-325712-9kbnyqt3 58 28 bulk bulk JJ cord-325712-9kbnyqt3 58 29 solution solution NN cord-325712-9kbnyqt3 58 30 and and CC cord-325712-9kbnyqt3 58 31 thereby thereby RB cord-325712-9kbnyqt3 58 32 enhancing enhance VBG cord-325712-9kbnyqt3 58 33 the the DT cord-325712-9kbnyqt3 58 34 signal signal NN cord-325712-9kbnyqt3 58 35 - - HYPH cord-325712-9kbnyqt3 58 36 to to IN cord-325712-9kbnyqt3 58 37 - - HYPH cord-325712-9kbnyqt3 58 38 noise noise NN cord-325712-9kbnyqt3 58 39 . . . cord-325712-9kbnyqt3 59 1 This this DT cord-325712-9kbnyqt3 59 2 configuration configuration NN cord-325712-9kbnyqt3 59 3 is be VBZ cord-325712-9kbnyqt3 59 4 achieved achieve VBN cord-325712-9kbnyqt3 59 5 by by IN cord-325712-9kbnyqt3 59 6 setting set VBG cord-325712-9kbnyqt3 59 7 the the DT cord-325712-9kbnyqt3 59 8 incidence incidence NN cord-325712-9kbnyqt3 59 9 angle angle NN cord-325712-9kbnyqt3 59 10 of of IN cord-325712-9kbnyqt3 59 11 the the DT cord-325712-9kbnyqt3 59 12 laser laser NN cord-325712-9kbnyqt3 59 13 to to TO cord-325712-9kbnyqt3 59 14 be be VB cord-325712-9kbnyqt3 59 15 higher high JJR cord-325712-9kbnyqt3 59 16 than than IN cord-325712-9kbnyqt3 59 17 the the DT cord-325712-9kbnyqt3 59 18 critical critical JJ cord-325712-9kbnyqt3 59 19 angle angle NN cord-325712-9kbnyqt3 59 20 for for IN cord-325712-9kbnyqt3 59 21 total total JJ cord-325712-9kbnyqt3 59 22 internal internal JJ cord-325712-9kbnyqt3 59 23 reflection reflection NN cord-325712-9kbnyqt3 59 24 of of IN cord-325712-9kbnyqt3 59 25 the the DT cord-325712-9kbnyqt3 59 26 laser laser NN cord-325712-9kbnyqt3 59 27 light light NN cord-325712-9kbnyqt3 59 28 at at IN cord-325712-9kbnyqt3 59 29 the the DT cord-325712-9kbnyqt3 59 30 glass glass NN cord-325712-9kbnyqt3 59 31 / / SYM cord-325712-9kbnyqt3 59 32 water water NN cord-325712-9kbnyqt3 59 33 or or CC cord-325712-9kbnyqt3 59 34 glass glass NN cord-325712-9kbnyqt3 59 35 / / SYM cord-325712-9kbnyqt3 59 36 cell cell NN cord-325712-9kbnyqt3 59 37 interface interface NN cord-325712-9kbnyqt3 59 38 , , , cord-325712-9kbnyqt3 59 39 resulting result VBG cord-325712-9kbnyqt3 59 40 in in IN cord-325712-9kbnyqt3 59 41 an an DT cord-325712-9kbnyqt3 59 42 exponentially exponentially RB cord-325712-9kbnyqt3 59 43 decaying decaying JJ cord-325712-9kbnyqt3 59 44 evanescent evanescent JJ cord-325712-9kbnyqt3 59 45 field field NN cord-325712-9kbnyqt3 59 46 that that WDT cord-325712-9kbnyqt3 59 47 penetrates penetrate VBZ cord-325712-9kbnyqt3 59 48 roughly roughly RB cord-325712-9kbnyqt3 59 49 100 100 CD cord-325712-9kbnyqt3 59 50 nm nm NN cord-325712-9kbnyqt3 59 51 into into IN cord-325712-9kbnyqt3 59 52 the the DT cord-325712-9kbnyqt3 59 53 sample sample NN cord-325712-9kbnyqt3 59 54 [ [ -LRB- cord-325712-9kbnyqt3 59 55 24 24 CD cord-325712-9kbnyqt3 59 56 , , , cord-325712-9kbnyqt3 59 57 25 25 CD cord-325712-9kbnyqt3 59 58 ] ] -RRB- cord-325712-9kbnyqt3 59 59 . . . cord-325712-9kbnyqt3 60 1 The the DT cord-325712-9kbnyqt3 60 2 advantage advantage NN cord-325712-9kbnyqt3 60 3 with with IN cord-325712-9kbnyqt3 60 4 this this DT cord-325712-9kbnyqt3 60 5 configuration configuration NN cord-325712-9kbnyqt3 60 6 is be VBZ cord-325712-9kbnyqt3 60 7 that that IN cord-325712-9kbnyqt3 60 8 a a DT cord-325712-9kbnyqt3 60 9 two two CD cord-325712-9kbnyqt3 60 10 - - HYPH cord-325712-9kbnyqt3 60 11 dimensional dimensional JJ cord-325712-9kbnyqt3 60 12 plane plane NN cord-325712-9kbnyqt3 60 13 can can MD cord-325712-9kbnyqt3 60 14 be be VB cord-325712-9kbnyqt3 60 15 monitored monitor VBN cord-325712-9kbnyqt3 60 16 precisely precisely RB cord-325712-9kbnyqt3 60 17 , , , cord-325712-9kbnyqt3 60 18 enabling enable VBG cord-325712-9kbnyqt3 60 19 the the DT cord-325712-9kbnyqt3 60 20 distinction distinction NN cord-325712-9kbnyqt3 60 21 between between IN cord-325712-9kbnyqt3 60 22 binding binding NN cord-325712-9kbnyqt3 60 23 and and CC cord-325712-9kbnyqt3 60 24 fusion fusion NN cord-325712-9kbnyqt3 60 25 events event NNS cord-325712-9kbnyqt3 60 26 of of IN cord-325712-9kbnyqt3 60 27 the the DT cord-325712-9kbnyqt3 60 28 virions virion NNS cord-325712-9kbnyqt3 60 29 , , , cord-325712-9kbnyqt3 60 30 with with IN cord-325712-9kbnyqt3 60 31 appropriate appropriate JJ cord-325712-9kbnyqt3 60 32 virion virion NN cord-325712-9kbnyqt3 60 33 labeling labeling NN cord-325712-9kbnyqt3 60 34 ( ( -LRB- cord-325712-9kbnyqt3 60 35 described describe VBN cord-325712-9kbnyqt3 60 36 next next RB cord-325712-9kbnyqt3 60 37 ) ) -RRB- cord-325712-9kbnyqt3 60 38 . . . cord-325712-9kbnyqt3 61 1 However however RB cord-325712-9kbnyqt3 61 2 , , , cord-325712-9kbnyqt3 61 3 no no DT cord-325712-9kbnyqt3 61 4 three three CD cord-325712-9kbnyqt3 61 5 dimensional dimensional JJ cord-325712-9kbnyqt3 61 6 tracking tracking NN cord-325712-9kbnyqt3 61 7 information information NN cord-325712-9kbnyqt3 61 8 can can MD cord-325712-9kbnyqt3 61 9 be be VB cord-325712-9kbnyqt3 61 10 obtained obtain VBN cord-325712-9kbnyqt3 61 11 ; ; : cord-325712-9kbnyqt3 61 12 data datum NNS cord-325712-9kbnyqt3 61 13 collection collection NN cord-325712-9kbnyqt3 61 14 is be VBZ cord-325712-9kbnyqt3 61 15 confined confine VBN cord-325712-9kbnyqt3 61 16 to to IN cord-325712-9kbnyqt3 61 17 the the DT cord-325712-9kbnyqt3 61 18 interfacial interfacial JJ cord-325712-9kbnyqt3 61 19 region region NN cord-325712-9kbnyqt3 61 20 of of IN cord-325712-9kbnyqt3 61 21 interest interest NN cord-325712-9kbnyqt3 61 22 . . . cord-325712-9kbnyqt3 62 1 This this DT cord-325712-9kbnyqt3 62 2 configuration configuration NN cord-325712-9kbnyqt3 62 3 is be VBZ cord-325712-9kbnyqt3 62 4 most most RBS cord-325712-9kbnyqt3 62 5 suitable suitable JJ cord-325712-9kbnyqt3 62 6 for for IN cord-325712-9kbnyqt3 62 7 examination examination NN cord-325712-9kbnyqt3 62 8 of of IN cord-325712-9kbnyqt3 62 9 virus virus NN cord-325712-9kbnyqt3 62 10 behavior behavior NN cord-325712-9kbnyqt3 62 11 at at IN cord-325712-9kbnyqt3 62 12 biomimetic biomimetic JJ cord-325712-9kbnyqt3 62 13 surfaces surface NNS cord-325712-9kbnyqt3 62 14 like like IN cord-325712-9kbnyqt3 62 15 supported support VBN cord-325712-9kbnyqt3 62 16 lipid lipid NN cord-325712-9kbnyqt3 62 17 bilayers bilayer NNS cord-325712-9kbnyqt3 62 18 or or CC cord-325712-9kbnyqt3 62 19 live live JJ cord-325712-9kbnyqt3 62 20 cell cell NN cord-325712-9kbnyqt3 62 21 plasma plasma NN cord-325712-9kbnyqt3 62 22 membranes membrane NNS cord-325712-9kbnyqt3 62 23 close close RB cord-325712-9kbnyqt3 62 24 to to IN cord-325712-9kbnyqt3 62 25 the the DT cord-325712-9kbnyqt3 62 26 glass glass NN cord-325712-9kbnyqt3 62 27 surface surface NN cord-325712-9kbnyqt3 62 28 . . . cord-325712-9kbnyqt3 63 1 In in IN cord-325712-9kbnyqt3 63 2 the the DT cord-325712-9kbnyqt3 63 3 confocal confocal JJ cord-325712-9kbnyqt3 63 4 microscopy microscopy NN cord-325712-9kbnyqt3 63 5 configuration configuration NN cord-325712-9kbnyqt3 63 6 ( ( -LRB- cord-325712-9kbnyqt3 63 7 Fig Fig NNP cord-325712-9kbnyqt3 63 8 . . NNP cord-325712-9kbnyqt3 63 9 2 2 CD cord-325712-9kbnyqt3 63 10 .3c .3c NFP cord-325712-9kbnyqt3 63 11 ) ) -RRB- cord-325712-9kbnyqt3 63 12 , , , cord-325712-9kbnyqt3 63 13 a a DT cord-325712-9kbnyqt3 63 14 pinhole pinhole NN cord-325712-9kbnyqt3 63 15 optic optic NN cord-325712-9kbnyqt3 63 16 assists assist VBZ cord-325712-9kbnyqt3 63 17 in in IN cord-325712-9kbnyqt3 63 18 filtering filter VBG cord-325712-9kbnyqt3 63 19 out out RP cord-325712-9kbnyqt3 63 20 background background NN cord-325712-9kbnyqt3 63 21 noise noise NN cord-325712-9kbnyqt3 63 22 while while IN cord-325712-9kbnyqt3 63 23 scanning scan VBG cord-325712-9kbnyqt3 63 24 across across IN cord-325712-9kbnyqt3 63 25 a a DT cord-325712-9kbnyqt3 63 26 sample sample NN cord-325712-9kbnyqt3 63 27 one one CD cord-325712-9kbnyqt3 63 28 Z z NN cord-325712-9kbnyqt3 63 29 - - HYPH cord-325712-9kbnyqt3 63 30 plane plane NN cord-325712-9kbnyqt3 63 31 at at IN cord-325712-9kbnyqt3 63 32 a a DT cord-325712-9kbnyqt3 63 33 time time NN cord-325712-9kbnyqt3 63 34 . . . cord-325712-9kbnyqt3 64 1 Cross cross NN cord-325712-9kbnyqt3 64 2 sections section NNS cord-325712-9kbnyqt3 64 3 may may MD cord-325712-9kbnyqt3 64 4 be be VB cord-325712-9kbnyqt3 64 5 stacked stack VBN cord-325712-9kbnyqt3 64 6 to to TO cord-325712-9kbnyqt3 64 7 yield yield VB cord-325712-9kbnyqt3 64 8 a a DT cord-325712-9kbnyqt3 64 9 three three CD cord-325712-9kbnyqt3 64 10 - - HYPH cord-325712-9kbnyqt3 64 11 dimensional dimensional JJ cord-325712-9kbnyqt3 64 12 image image NN cord-325712-9kbnyqt3 64 13 , , , cord-325712-9kbnyqt3 64 14 making make VBG cord-325712-9kbnyqt3 64 15 this this DT cord-325712-9kbnyqt3 64 16 configuration configuration NN cord-325712-9kbnyqt3 64 17 suitable suitable JJ cord-325712-9kbnyqt3 64 18 for for IN cord-325712-9kbnyqt3 64 19 imaging image VBG cord-325712-9kbnyqt3 64 20 live live JJ cord-325712-9kbnyqt3 64 21 or or CC cord-325712-9kbnyqt3 64 22 fixed fix VBN cord-325712-9kbnyqt3 64 23 cells cell NNS cord-325712-9kbnyqt3 64 24 and and CC cord-325712-9kbnyqt3 64 25 observing observe VBG cord-325712-9kbnyqt3 64 26 trafficking trafficking NN cord-325712-9kbnyqt3 64 27 of of IN cord-325712-9kbnyqt3 64 28 viruses virus NNS cord-325712-9kbnyqt3 64 29 in in IN cord-325712-9kbnyqt3 64 30 the the DT cord-325712-9kbnyqt3 64 31 cytosol cytosol NN cord-325712-9kbnyqt3 64 32 . . . cord-325712-9kbnyqt3 65 1 The the DT cord-325712-9kbnyqt3 65 2 disadvantage disadvantage NN cord-325712-9kbnyqt3 65 3 of of IN cord-325712-9kbnyqt3 65 4 this this DT cord-325712-9kbnyqt3 65 5 configuration configuration NN cord-325712-9kbnyqt3 65 6 is be VBZ cord-325712-9kbnyqt3 65 7 the the DT cord-325712-9kbnyqt3 65 8 difficulty difficulty NN cord-325712-9kbnyqt3 65 9 in in IN cord-325712-9kbnyqt3 65 10 temporally temporally RB cord-325712-9kbnyqt3 65 11 tracking track VBG cord-325712-9kbnyqt3 65 12 phenomena phenomenon NNS cord-325712-9kbnyqt3 65 13 in in IN cord-325712-9kbnyqt3 65 14 real real JJ cord-325712-9kbnyqt3 65 15 - - HYPH cord-325712-9kbnyqt3 65 16 time time NN cord-325712-9kbnyqt3 65 17 , , , cord-325712-9kbnyqt3 65 18 while while IN cord-325712-9kbnyqt3 65 19 simultaneously simultaneously RB cord-325712-9kbnyqt3 65 20 scanning scan VBG cord-325712-9kbnyqt3 65 21 across across IN cord-325712-9kbnyqt3 65 22 slices slice NNS cord-325712-9kbnyqt3 65 23 of of IN cord-325712-9kbnyqt3 65 24 the the DT cord-325712-9kbnyqt3 65 25 sample sample NN cord-325712-9kbnyqt3 65 26 and and CC cord-325712-9kbnyqt3 65 27 reconstructing reconstruct VBG cord-325712-9kbnyqt3 65 28 the the DT cord-325712-9kbnyqt3 65 29 image image NN cord-325712-9kbnyqt3 65 30 . . . cord-325712-9kbnyqt3 66 1 Furthermore furthermore RB cord-325712-9kbnyqt3 66 2 , , , cord-325712-9kbnyqt3 66 3 exposure exposure NN cord-325712-9kbnyqt3 66 4 to to IN cord-325712-9kbnyqt3 66 5 strong strong JJ cord-325712-9kbnyqt3 66 6 light light NN cord-325712-9kbnyqt3 66 7 can can MD cord-325712-9kbnyqt3 66 8 be be VB cord-325712-9kbnyqt3 66 9 toxic toxic JJ cord-325712-9kbnyqt3 66 10 to to IN cord-325712-9kbnyqt3 66 11 living living NN cord-325712-9kbnyqt3 66 12 cells cell NNS cord-325712-9kbnyqt3 66 13 [ [ -LRB- cord-325712-9kbnyqt3 66 14 26 26 CD cord-325712-9kbnyqt3 66 15 ] ] -RRB- cord-325712-9kbnyqt3 66 16 . . . cord-325712-9kbnyqt3 67 1 As as IN cord-325712-9kbnyqt3 67 2 technology technology NN cord-325712-9kbnyqt3 67 3 advances advance VBZ cord-325712-9kbnyqt3 67 4 , , , cord-325712-9kbnyqt3 67 5 these these DT cord-325712-9kbnyqt3 67 6 drawbacks drawback NNS cord-325712-9kbnyqt3 67 7 should should MD cord-325712-9kbnyqt3 67 8 subside subside VB cord-325712-9kbnyqt3 67 9 . . . cord-325712-9kbnyqt3 68 1 In in IN cord-325712-9kbnyqt3 68 2 all all DT cord-325712-9kbnyqt3 68 3 of of IN cord-325712-9kbnyqt3 68 4 these these DT cord-325712-9kbnyqt3 68 5 microscopy microscopy NN cord-325712-9kbnyqt3 68 6 techniques technique NNS cord-325712-9kbnyqt3 68 7 , , , cord-325712-9kbnyqt3 68 8 virions virion NNS cord-325712-9kbnyqt3 68 9 must must MD cord-325712-9kbnyqt3 68 10 be be VB cord-325712-9kbnyqt3 68 11 labeled label VBN cord-325712-9kbnyqt3 68 12 to to TO cord-325712-9kbnyqt3 68 13 visualize visualize VB cord-325712-9kbnyqt3 68 14 them -PRON- PRP cord-325712-9kbnyqt3 68 15 . . . cord-325712-9kbnyqt3 69 1 Virions virion NNS cord-325712-9kbnyqt3 69 2 are be VBP cord-325712-9kbnyqt3 69 3 commonly commonly RB cord-325712-9kbnyqt3 69 4 labeled label VBN cord-325712-9kbnyqt3 69 5 by by IN cord-325712-9kbnyqt3 69 6 attaching attach VBG cord-325712-9kbnyqt3 69 7 fluorescent fluorescent NN cord-325712-9kbnyqt3 69 8 proteins protein NNS cord-325712-9kbnyqt3 69 9 to to IN cord-325712-9kbnyqt3 69 10 viral viral JJ cord-325712-9kbnyqt3 69 11 proteins protein NNS cord-325712-9kbnyqt3 69 12 , , , cord-325712-9kbnyqt3 69 13 by by IN cord-325712-9kbnyqt3 69 14 incorporating incorporate VBG cord-325712-9kbnyqt3 69 15 chemical chemical JJ cord-325712-9kbnyqt3 69 16 dyes dye NNS cord-325712-9kbnyqt3 69 17 into into IN cord-325712-9kbnyqt3 69 18 the the DT cord-325712-9kbnyqt3 69 19 virion virion NN cord-325712-9kbnyqt3 69 20 , , , cord-325712-9kbnyqt3 69 21 or or CC cord-325712-9kbnyqt3 69 22 by by IN cord-325712-9kbnyqt3 69 23 incorporating incorporate VBG cord-325712-9kbnyqt3 69 24 quantum quantum NN cord-325712-9kbnyqt3 69 25 dots dot NNS cord-325712-9kbnyqt3 69 26 [ [ -LRB- cord-325712-9kbnyqt3 69 27 27 27 CD cord-325712-9kbnyqt3 69 28 ] ] -RRB- cord-325712-9kbnyqt3 69 29 [ [ -LRB- cord-325712-9kbnyqt3 69 30 28 28 CD cord-325712-9kbnyqt3 69 31 ] ] -RRB- cord-325712-9kbnyqt3 69 32 [ [ -LRB- cord-325712-9kbnyqt3 69 33 29 29 CD cord-325712-9kbnyqt3 69 34 ] ] -RRB- cord-325712-9kbnyqt3 69 35 . . . cord-325712-9kbnyqt3 70 1 Here here RB cord-325712-9kbnyqt3 70 2 , , , cord-325712-9kbnyqt3 70 3 we -PRON- PRP cord-325712-9kbnyqt3 70 4 focus focus VBP cord-325712-9kbnyqt3 70 5 on on IN cord-325712-9kbnyqt3 70 6 fluorescent fluorescent JJ cord-325712-9kbnyqt3 70 7 and and CC cord-325712-9kbnyqt3 70 8 chemical chemical JJ cord-325712-9kbnyqt3 70 9 labels label NNS cord-325712-9kbnyqt3 70 10 ; ; : cord-325712-9kbnyqt3 70 11 for for IN cord-325712-9kbnyqt3 70 12 a a DT cord-325712-9kbnyqt3 70 13 review review NN cord-325712-9kbnyqt3 70 14 of of IN cord-325712-9kbnyqt3 70 15 quantum quantum NN cord-325712-9kbnyqt3 70 16 dot dot NN cord-325712-9kbnyqt3 70 17 techniques technique NNS cord-325712-9kbnyqt3 70 18 we -PRON- PRP cord-325712-9kbnyqt3 70 19 refer refer VBP cord-325712-9kbnyqt3 70 20 the the DT cord-325712-9kbnyqt3 70 21 reader reader NN cord-325712-9kbnyqt3 70 22 to to IN cord-325712-9kbnyqt3 70 23 Liu Liu NNP cord-325712-9kbnyqt3 70 24 et et NNP cord-325712-9kbnyqt3 70 25 al al NNP cord-325712-9kbnyqt3 70 26 . . . cord-325712-9kbnyqt3 71 1 [ [ -LRB- cord-325712-9kbnyqt3 71 2 28 28 CD cord-325712-9kbnyqt3 71 3 ] ] -RRB- cord-325712-9kbnyqt3 71 4 . . . cord-325712-9kbnyqt3 72 1 Both both DT cord-325712-9kbnyqt3 72 2 fluorescent fluorescent JJ cord-325712-9kbnyqt3 72 3 proteins protein NNS cord-325712-9kbnyqt3 72 4 and and CC cord-325712-9kbnyqt3 72 5 chemical chemical NN cord-325712-9kbnyqt3 72 6 labels label NNS cord-325712-9kbnyqt3 72 7 have have VBP cord-325712-9kbnyqt3 72 8 been be VBN cord-325712-9kbnyqt3 72 9 used use VBN cord-325712-9kbnyqt3 72 10 to to TO cord-325712-9kbnyqt3 72 11 label label VB cord-325712-9kbnyqt3 72 12 viral viral JJ cord-325712-9kbnyqt3 72 13 coatings coating NNS cord-325712-9kbnyqt3 72 14 as as RB cord-325712-9kbnyqt3 72 15 well well RB cord-325712-9kbnyqt3 72 16 as as IN cord-325712-9kbnyqt3 72 17 contents content NNS cord-325712-9kbnyqt3 72 18 . . . cord-325712-9kbnyqt3 73 1 Fluorescent fluorescent JJ cord-325712-9kbnyqt3 73 2 viral viral JJ cord-325712-9kbnyqt3 73 3 protein protein NN cord-325712-9kbnyqt3 73 4 constructs construct NNS cord-325712-9kbnyqt3 73 5 can can MD cord-325712-9kbnyqt3 73 6 be be VB cord-325712-9kbnyqt3 73 7 prepared prepare VBN cord-325712-9kbnyqt3 73 8 for for IN cord-325712-9kbnyqt3 73 9 enveloped envelop VBN cord-325712-9kbnyqt3 73 10 [ [ -LRB- cord-325712-9kbnyqt3 73 11 30 30 CD cord-325712-9kbnyqt3 73 12 ] ] -RRB- cord-325712-9kbnyqt3 73 13 or or CC cord-325712-9kbnyqt3 73 14 non non JJ cord-325712-9kbnyqt3 73 15 - - JJ cord-325712-9kbnyqt3 73 16 enveloped enveloped JJ cord-325712-9kbnyqt3 73 17 viruses virus NNS cord-325712-9kbnyqt3 73 18 [ [ -LRB- cord-325712-9kbnyqt3 73 19 31 31 CD cord-325712-9kbnyqt3 73 20 , , , cord-325712-9kbnyqt3 73 21 32 32 CD cord-325712-9kbnyqt3 73 22 ] ] -RRB- cord-325712-9kbnyqt3 73 23 and and CC cord-325712-9kbnyqt3 73 24 virions virion NNS cord-325712-9kbnyqt3 73 25 are be VBP cord-325712-9kbnyqt3 73 26 labeled label VBN cord-325712-9kbnyqt3 73 27 as as IN cord-325712-9kbnyqt3 73 28 they -PRON- PRP cord-325712-9kbnyqt3 73 29 are be VBP cord-325712-9kbnyqt3 73 30 synthesized synthesize VBN cord-325712-9kbnyqt3 73 31 . . . cord-325712-9kbnyqt3 74 1 Chemical chemical JJ cord-325712-9kbnyqt3 74 2 labels label NNS cord-325712-9kbnyqt3 74 3 , , , cord-325712-9kbnyqt3 74 4 including include VBG cord-325712-9kbnyqt3 74 5 Alexa Alexa NNP cord-325712-9kbnyqt3 74 6 dyes dye NNS cord-325712-9kbnyqt3 74 7 , , , cord-325712-9kbnyqt3 74 8 octadecylrhodamine octadecylrhodamine NN cord-325712-9kbnyqt3 74 9 B b NN cord-325712-9kbnyqt3 74 10 ( ( -LRB- cord-325712-9kbnyqt3 74 11 R18 R18 NNP cord-325712-9kbnyqt3 74 12 ) ) -RRB- cord-325712-9kbnyqt3 74 13 , , , cord-325712-9kbnyqt3 74 14 and and CC cord-325712-9kbnyqt3 74 15 carbocyanine carbocyanine JJ cord-325712-9kbnyqt3 74 16 perchlorates perchlorate NNS cord-325712-9kbnyqt3 74 17 ( ( -LRB- cord-325712-9kbnyqt3 74 18 DiD do VBD cord-325712-9kbnyqt3 74 19 , , , cord-325712-9kbnyqt3 74 20 DiI DiI NNP cord-325712-9kbnyqt3 74 21 , , , cord-325712-9kbnyqt3 74 22 or or CC cord-325712-9kbnyqt3 74 23 DiO dio NN cord-325712-9kbnyqt3 74 24 ) ) -RRB- cord-325712-9kbnyqt3 74 25 may may MD cord-325712-9kbnyqt3 74 26 be be VB cord-325712-9kbnyqt3 74 27 added add VBN cord-325712-9kbnyqt3 74 28 during during IN cord-325712-9kbnyqt3 74 29 virion virion NN cord-325712-9kbnyqt3 74 30 synthesis synthesis NN cord-325712-9kbnyqt3 74 31 or or CC cord-325712-9kbnyqt3 74 32 post post NN cord-325712-9kbnyqt3 74 33 - - NN cord-325712-9kbnyqt3 74 34 production production NN cord-325712-9kbnyqt3 74 35 . . . cord-325712-9kbnyqt3 75 1 Some some DT cord-325712-9kbnyqt3 75 2 chemical chemical JJ cord-325712-9kbnyqt3 75 3 labels label NNS cord-325712-9kbnyqt3 75 4 , , , cord-325712-9kbnyqt3 75 5 like like IN cord-325712-9kbnyqt3 75 6 lipophilic lipophilic JJ cord-325712-9kbnyqt3 75 7 dyes dye NNS cord-325712-9kbnyqt3 75 8 , , , cord-325712-9kbnyqt3 75 9 are be VBP cord-325712-9kbnyqt3 75 10 only only RB cord-325712-9kbnyqt3 75 11 suitable suitable JJ cord-325712-9kbnyqt3 75 12 for for IN cord-325712-9kbnyqt3 75 13 labeling label VBG cord-325712-9kbnyqt3 75 14 enveloped envelop VBN cord-325712-9kbnyqt3 75 15 viruses virus NNS cord-325712-9kbnyqt3 75 16 while while IN cord-325712-9kbnyqt3 75 17 others other NNS cord-325712-9kbnyqt3 75 18 , , , cord-325712-9kbnyqt3 75 19 like like IN cord-325712-9kbnyqt3 75 20 amino amino NN cord-325712-9kbnyqt3 75 21 - - HYPH cord-325712-9kbnyqt3 75 22 reactive reactive JJ cord-325712-9kbnyqt3 75 23 dyes dye NNS cord-325712-9kbnyqt3 75 24 , , , cord-325712-9kbnyqt3 75 25 may may MD cord-325712-9kbnyqt3 75 26 be be VB cord-325712-9kbnyqt3 75 27 employed employ VBN cord-325712-9kbnyqt3 75 28 with with IN cord-325712-9kbnyqt3 75 29 either either CC cord-325712-9kbnyqt3 75 30 enveloped envelop VBN cord-325712-9kbnyqt3 75 31 or or CC cord-325712-9kbnyqt3 75 32 non non JJ cord-325712-9kbnyqt3 75 33 - - JJ cord-325712-9kbnyqt3 75 34 enveloped enveloped JJ cord-325712-9kbnyqt3 75 35 virions virion NNS cord-325712-9kbnyqt3 75 36 [ [ -LRB- cord-325712-9kbnyqt3 75 37 22 22 CD cord-325712-9kbnyqt3 75 38 ] ] -RRB- cord-325712-9kbnyqt3 75 39 . . . cord-325712-9kbnyqt3 76 1 Membrane membrane NN cord-325712-9kbnyqt3 76 2 hemifusion hemifusion NN cord-325712-9kbnyqt3 76 3 is be VBZ cord-325712-9kbnyqt3 76 4 typically typically RB cord-325712-9kbnyqt3 76 5 monitored monitor VBN cord-325712-9kbnyqt3 76 6 with with IN cord-325712-9kbnyqt3 76 7 lipophilic lipophilic JJ cord-325712-9kbnyqt3 76 8 dyes dye NNS cord-325712-9kbnyqt3 76 9 that that WDT cord-325712-9kbnyqt3 76 10 undergo undergo VBP cord-325712-9kbnyqt3 76 11 dequenching dequenching NN cord-325712-9kbnyqt3 76 12 when when WRB cord-325712-9kbnyqt3 76 13 the the DT cord-325712-9kbnyqt3 76 14 virion virion NN cord-325712-9kbnyqt3 76 15 fuses fuse VBZ cord-325712-9kbnyqt3 76 16 with with IN cord-325712-9kbnyqt3 76 17 the the DT cord-325712-9kbnyqt3 76 18 target target NN cord-325712-9kbnyqt3 76 19 membrane membrane NN cord-325712-9kbnyqt3 76 20 , , , cord-325712-9kbnyqt3 76 21 while while IN cord-325712-9kbnyqt3 76 22 pore pore NN cord-325712-9kbnyqt3 76 23 formation formation NN cord-325712-9kbnyqt3 76 24 is be VBZ cord-325712-9kbnyqt3 76 25 typically typically RB cord-325712-9kbnyqt3 76 26 tracked track VBN cord-325712-9kbnyqt3 76 27 with with IN cord-325712-9kbnyqt3 76 28 a a DT cord-325712-9kbnyqt3 76 29 dye dye NN cord-325712-9kbnyqt3 76 30 that that WDT cord-325712-9kbnyqt3 76 31 can can MD cord-325712-9kbnyqt3 76 32 partition partition VB cord-325712-9kbnyqt3 76 33 into into IN cord-325712-9kbnyqt3 76 34 the the DT cord-325712-9kbnyqt3 76 35 capsid capsid NN cord-325712-9kbnyqt3 76 36 and and CC cord-325712-9kbnyqt3 76 37 then then RB cord-325712-9kbnyqt3 76 38 dissipate dissipate VB cord-325712-9kbnyqt3 76 39 upon upon IN cord-325712-9kbnyqt3 76 40 release release NN cord-325712-9kbnyqt3 76 41 from from IN cord-325712-9kbnyqt3 76 42 the the DT cord-325712-9kbnyqt3 76 43 virion virion NN cord-325712-9kbnyqt3 76 44 [ [ -LRB- cord-325712-9kbnyqt3 76 45 33 33 CD cord-325712-9kbnyqt3 76 46 , , , cord-325712-9kbnyqt3 76 47 34 34 CD cord-325712-9kbnyqt3 76 48 ] ] -RRB- cord-325712-9kbnyqt3 76 49 . . . cord-325712-9kbnyqt3 77 1 It -PRON- PRP cord-325712-9kbnyqt3 77 2 is be VBZ cord-325712-9kbnyqt3 77 3 also also RB cord-325712-9kbnyqt3 77 4 possible possible JJ cord-325712-9kbnyqt3 77 5 to to TO cord-325712-9kbnyqt3 77 6 incorporate incorporate VB cord-325712-9kbnyqt3 77 7 pH pH NNP cord-325712-9kbnyqt3 77 8 sensors sensor NNS cord-325712-9kbnyqt3 77 9 into into IN cord-325712-9kbnyqt3 77 10 the the DT cord-325712-9kbnyqt3 77 11 envelope envelope NN cord-325712-9kbnyqt3 77 12 of of IN cord-325712-9kbnyqt3 77 13 virions virion NNS cord-325712-9kbnyqt3 77 14 to to TO cord-325712-9kbnyqt3 77 15 measure measure VB cord-325712-9kbnyqt3 77 16 the the DT cord-325712-9kbnyqt3 77 17 pH ph NN cord-325712-9kbnyqt3 77 18 of of IN cord-325712-9kbnyqt3 77 19 the the DT cord-325712-9kbnyqt3 77 20 fusion fusion NN cord-325712-9kbnyqt3 77 21 environment environment NN cord-325712-9kbnyqt3 77 22 [ [ -LRB- cord-325712-9kbnyqt3 77 23 35 35 CD cord-325712-9kbnyqt3 77 24 ] ] -RRB- cord-325712-9kbnyqt3 77 25 . . . cord-325712-9kbnyqt3 78 1 In in IN cord-325712-9kbnyqt3 78 2 all all DT cord-325712-9kbnyqt3 78 3 cases case NNS cord-325712-9kbnyqt3 78 4 , , , cord-325712-9kbnyqt3 78 5 care care NN cord-325712-9kbnyqt3 78 6 must must MD cord-325712-9kbnyqt3 78 7 be be VB cord-325712-9kbnyqt3 78 8 taken take VBN cord-325712-9kbnyqt3 78 9 to to TO cord-325712-9kbnyqt3 78 10 ensure ensure VB cord-325712-9kbnyqt3 78 11 that that IN cord-325712-9kbnyqt3 78 12 labeling labeling NN cord-325712-9kbnyqt3 78 13 does do VBZ cord-325712-9kbnyqt3 78 14 not not RB cord-325712-9kbnyqt3 78 15 adversely adversely RB cord-325712-9kbnyqt3 78 16 impact impact VB cord-325712-9kbnyqt3 78 17 viral viral JJ cord-325712-9kbnyqt3 78 18 infectivity infectivity NN cord-325712-9kbnyqt3 78 19 . . . cord-325712-9kbnyqt3 79 1 This this DT cord-325712-9kbnyqt3 79 2 can can MD cord-325712-9kbnyqt3 79 3 be be VB cord-325712-9kbnyqt3 79 4 easily easily RB cord-325712-9kbnyqt3 79 5 assessed assess VBN cord-325712-9kbnyqt3 79 6 by by IN cord-325712-9kbnyqt3 79 7 conducting conduct VBG cord-325712-9kbnyqt3 79 8 cell cell NN cord-325712-9kbnyqt3 79 9 infectivity infectivity NN cord-325712-9kbnyqt3 79 10 assays assays RB cord-325712-9kbnyqt3 79 11 with with IN cord-325712-9kbnyqt3 79 12 labeled label VBN cord-325712-9kbnyqt3 79 13 virions virion NNS cord-325712-9kbnyqt3 79 14 . . . cord-325712-9kbnyqt3 80 1 In in IN cord-325712-9kbnyqt3 80 2 general general JJ cord-325712-9kbnyqt3 80 3 , , , cord-325712-9kbnyqt3 80 4 these these DT cord-325712-9kbnyqt3 80 5 labeling labeling NN cord-325712-9kbnyqt3 80 6 approaches approach NNS cord-325712-9kbnyqt3 80 7 can can MD cord-325712-9kbnyqt3 80 8 be be VB cord-325712-9kbnyqt3 80 9 optimized optimize VBN cord-325712-9kbnyqt3 80 10 to to TO cord-325712-9kbnyqt3 80 11 mitigate mitigate VB cord-325712-9kbnyqt3 80 12 any any DT cord-325712-9kbnyqt3 80 13 significant significant JJ cord-325712-9kbnyqt3 80 14 negative negative JJ cord-325712-9kbnyqt3 80 15 impact impact NN cord-325712-9kbnyqt3 80 16 . . . cord-325712-9kbnyqt3 81 1 Once once IN cord-325712-9kbnyqt3 81 2 the the DT cord-325712-9kbnyqt3 81 3 microscopy microscopy NN cord-325712-9kbnyqt3 81 4 configuration configuration NN cord-325712-9kbnyqt3 81 5 and and CC cord-325712-9kbnyqt3 81 6 virion virion NN cord-325712-9kbnyqt3 81 7 labeling labeling NN cord-325712-9kbnyqt3 81 8 method method NN cord-325712-9kbnyqt3 81 9 have have VBP cord-325712-9kbnyqt3 81 10 been be VBN cord-325712-9kbnyqt3 81 11 chosen choose VBN cord-325712-9kbnyqt3 81 12 , , , cord-325712-9kbnyqt3 81 13 image image NN cord-325712-9kbnyqt3 81 14 processing processing NN cord-325712-9kbnyqt3 81 15 assists assist VBZ cord-325712-9kbnyqt3 81 16 in in IN cord-325712-9kbnyqt3 81 17 extracting extract VBG cord-325712-9kbnyqt3 81 18 information information NN cord-325712-9kbnyqt3 81 19 from from IN cord-325712-9kbnyqt3 81 20 the the DT cord-325712-9kbnyqt3 81 21 images image NNS cord-325712-9kbnyqt3 81 22 . . . cord-325712-9kbnyqt3 82 1 Today today NN cord-325712-9kbnyqt3 82 2 's 's POS cord-325712-9kbnyqt3 82 3 fast fast JJ cord-325712-9kbnyqt3 82 4 computers computer NNS cord-325712-9kbnyqt3 82 5 and and CC cord-325712-9kbnyqt3 82 6 image image NN cord-325712-9kbnyqt3 82 7 processing processing NN cord-325712-9kbnyqt3 82 8 algorithms algorithm NNS cord-325712-9kbnyqt3 82 9 assist assist VBP cord-325712-9kbnyqt3 82 10 in in IN cord-325712-9kbnyqt3 82 11 noise noise NN cord-325712-9kbnyqt3 82 12 filtering filtering NN cord-325712-9kbnyqt3 82 13 , , , cord-325712-9kbnyqt3 82 14 virion virion NN cord-325712-9kbnyqt3 82 15 tracking tracking NN cord-325712-9kbnyqt3 82 16 , , , cord-325712-9kbnyqt3 82 17 and and CC cord-325712-9kbnyqt3 82 18 trajectory trajectory NN cord-325712-9kbnyqt3 82 19 mapping mapping NN cord-325712-9kbnyqt3 82 20 , , , cord-325712-9kbnyqt3 82 21 as as IN cord-325712-9kbnyqt3 82 22 described describe VBN cord-325712-9kbnyqt3 82 23 in in IN cord-325712-9kbnyqt3 82 24 the the DT cord-325712-9kbnyqt3 82 25 references reference NNS cord-325712-9kbnyqt3 82 26 that that WDT cord-325712-9kbnyqt3 82 27 follow follow VBP cord-325712-9kbnyqt3 82 28 . . . cord-325712-9kbnyqt3 83 1 In in IN cord-325712-9kbnyqt3 83 2 single single JJ cord-325712-9kbnyqt3 83 3 virion virion NN cord-325712-9kbnyqt3 83 4 imaging imaging NN cord-325712-9kbnyqt3 83 5 , , , cord-325712-9kbnyqt3 83 6 noise noise NN cord-325712-9kbnyqt3 83 7 is be VBZ cord-325712-9kbnyqt3 83 8 always always RB cord-325712-9kbnyqt3 83 9 a a DT cord-325712-9kbnyqt3 83 10 primary primary JJ cord-325712-9kbnyqt3 83 11 concern concern NN cord-325712-9kbnyqt3 83 12 , , , cord-325712-9kbnyqt3 83 13 regardless regardless RB cord-325712-9kbnyqt3 83 14 of of IN cord-325712-9kbnyqt3 83 15 the the DT cord-325712-9kbnyqt3 83 16 microscope microscope NN cord-325712-9kbnyqt3 83 17 configuration configuration NN cord-325712-9kbnyqt3 83 18 . . . cord-325712-9kbnyqt3 84 1 To to TO cord-325712-9kbnyqt3 84 2 combat combat VB cord-325712-9kbnyqt3 84 3 this this DT cord-325712-9kbnyqt3 84 4 , , , cord-325712-9kbnyqt3 84 5 several several JJ cord-325712-9kbnyqt3 84 6 particle particle NN cord-325712-9kbnyqt3 84 7 detection detection NN cord-325712-9kbnyqt3 84 8 and and CC cord-325712-9kbnyqt3 84 9 image image NN cord-325712-9kbnyqt3 84 10 restoration restoration NN cord-325712-9kbnyqt3 84 11 techniques technique NNS cord-325712-9kbnyqt3 84 12 have have VBP cord-325712-9kbnyqt3 84 13 been be VBN cord-325712-9kbnyqt3 84 14 developed develop VBN cord-325712-9kbnyqt3 84 15 specifically specifically RB cord-325712-9kbnyqt3 84 16 for for IN cord-325712-9kbnyqt3 84 17 single single JJ cord-325712-9kbnyqt3 84 18 virion virion NN cord-325712-9kbnyqt3 84 19 tracking track VBG cord-325712-9kbnyqt3 84 20 [ [ -LRB- cord-325712-9kbnyqt3 84 21 36 36 CD cord-325712-9kbnyqt3 84 22 , , , cord-325712-9kbnyqt3 84 23 37 37 CD cord-325712-9kbnyqt3 84 24 ] ] -RRB- cord-325712-9kbnyqt3 84 25 . . . cord-325712-9kbnyqt3 85 1 Coordinates coordinate NNS cord-325712-9kbnyqt3 85 2 of of IN cord-325712-9kbnyqt3 85 3 the the DT cord-325712-9kbnyqt3 85 4 particles particle NNS cord-325712-9kbnyqt3 85 5 are be VBP cord-325712-9kbnyqt3 85 6 obtained obtain VBN cord-325712-9kbnyqt3 85 7 by by IN cord-325712-9kbnyqt3 85 8 scanning scan VBG cord-325712-9kbnyqt3 85 9 filtered filter VBN cord-325712-9kbnyqt3 85 10 images image NNS cord-325712-9kbnyqt3 85 11 for for IN cord-325712-9kbnyqt3 85 12 areas area NNS cord-325712-9kbnyqt3 85 13 of of IN cord-325712-9kbnyqt3 85 14 fluorescence fluorescence NN cord-325712-9kbnyqt3 85 15 intensity intensity NN cord-325712-9kbnyqt3 85 16 that that WDT cord-325712-9kbnyqt3 85 17 exceed exceed VBP cord-325712-9kbnyqt3 85 18 a a DT cord-325712-9kbnyqt3 85 19 certain certain JJ cord-325712-9kbnyqt3 85 20 threshold threshold NN cord-325712-9kbnyqt3 85 21 or or CC cord-325712-9kbnyqt3 85 22 fit fit VB cord-325712-9kbnyqt3 85 23 a a DT cord-325712-9kbnyqt3 85 24 particular particular JJ cord-325712-9kbnyqt3 85 25 intensity intensity NN cord-325712-9kbnyqt3 85 26 profile profile NN cord-325712-9kbnyqt3 85 27 [ [ -LRB- cord-325712-9kbnyqt3 85 28 38 38 CD cord-325712-9kbnyqt3 85 29 , , , cord-325712-9kbnyqt3 85 30 39 39 CD cord-325712-9kbnyqt3 85 31 ] ] -RRB- cord-325712-9kbnyqt3 85 32 . . . cord-325712-9kbnyqt3 86 1 The the DT cord-325712-9kbnyqt3 86 2 next next JJ cord-325712-9kbnyqt3 86 3 challenge challenge NN cord-325712-9kbnyqt3 86 4 is be VBZ cord-325712-9kbnyqt3 86 5 obtaining obtain VBG cord-325712-9kbnyqt3 86 6 accurate accurate JJ cord-325712-9kbnyqt3 86 7 virion virion NN cord-325712-9kbnyqt3 86 8 tracking track VBG cord-325712-9kbnyqt3 86 9 from from IN cord-325712-9kbnyqt3 86 10 one one CD cord-325712-9kbnyqt3 86 11 frame frame NN cord-325712-9kbnyqt3 86 12 to to IN cord-325712-9kbnyqt3 86 13 the the DT cord-325712-9kbnyqt3 86 14 next next JJ cord-325712-9kbnyqt3 86 15 ( ( -LRB- cord-325712-9kbnyqt3 86 16 temporal temporal JJ cord-325712-9kbnyqt3 86 17 trajectories trajectory NNS cord-325712-9kbnyqt3 86 18 ) ) -RRB- cord-325712-9kbnyqt3 86 19 . . . cord-325712-9kbnyqt3 87 1 Particle particle NN cord-325712-9kbnyqt3 87 2 trajectories trajectory NNS cord-325712-9kbnyqt3 87 3 can can MD cord-325712-9kbnyqt3 87 4 be be VB cord-325712-9kbnyqt3 87 5 calculated calculate VBN cord-325712-9kbnyqt3 87 6 from from IN cord-325712-9kbnyqt3 87 7 nearest near JJS cord-325712-9kbnyqt3 87 8 - - HYPH cord-325712-9kbnyqt3 87 9 neighbor neighbor NN cord-325712-9kbnyqt3 87 10 associations association NNS cord-325712-9kbnyqt3 87 11 [ [ -LRB- cord-325712-9kbnyqt3 87 12 21 21 CD cord-325712-9kbnyqt3 87 13 , , , cord-325712-9kbnyqt3 87 14 40 40 CD cord-325712-9kbnyqt3 87 15 ] ] -RRB- cord-325712-9kbnyqt3 87 16 . . . cord-325712-9kbnyqt3 88 1 Measurements measurement NNS cord-325712-9kbnyqt3 88 2 of of IN cord-325712-9kbnyqt3 88 3 virion virion NN cord-325712-9kbnyqt3 88 4 movement movement NN cord-325712-9kbnyqt3 88 5 and and CC cord-325712-9kbnyqt3 88 6 mean mean VB cord-325712-9kbnyqt3 88 7 squared squared JJ cord-325712-9kbnyqt3 88 8 displacements displacement NNS cord-325712-9kbnyqt3 88 9 are be VBP cord-325712-9kbnyqt3 88 10 then then RB cord-325712-9kbnyqt3 88 11 used use VBN cord-325712-9kbnyqt3 88 12 to to TO cord-325712-9kbnyqt3 88 13 determine determine VB cord-325712-9kbnyqt3 88 14 whether whether IN cord-325712-9kbnyqt3 88 15 the the DT cord-325712-9kbnyqt3 88 16 virions virion NNS cord-325712-9kbnyqt3 88 17 exhibit exhibit NN cord-325712-9kbnyqt3 88 18 directed direct VBN cord-325712-9kbnyqt3 88 19 , , , cord-325712-9kbnyqt3 88 20 normal normal JJ cord-325712-9kbnyqt3 88 21 , , , cord-325712-9kbnyqt3 88 22 or or CC cord-325712-9kbnyqt3 88 23 anomalous anomalous JJ cord-325712-9kbnyqt3 88 24 diffusion diffusion NN cord-325712-9kbnyqt3 88 25 [ [ -LRB- cord-325712-9kbnyqt3 88 26 41 41 CD cord-325712-9kbnyqt3 88 27 ] ] -RRB- cord-325712-9kbnyqt3 88 28 . . . cord-325712-9kbnyqt3 89 1 The the DT cord-325712-9kbnyqt3 89 2 diffusion diffusion NN cord-325712-9kbnyqt3 89 3 type type NN cord-325712-9kbnyqt3 89 4 can can MD cord-325712-9kbnyqt3 89 5 indicate indicate VB cord-325712-9kbnyqt3 89 6 the the DT cord-325712-9kbnyqt3 89 7 type type NN cord-325712-9kbnyqt3 89 8 of of IN cord-325712-9kbnyqt3 89 9 interactions interaction NNS cord-325712-9kbnyqt3 89 10 the the DT cord-325712-9kbnyqt3 89 11 virion virion NN cord-325712-9kbnyqt3 89 12 is be VBZ cord-325712-9kbnyqt3 89 13 having have VBG cord-325712-9kbnyqt3 89 14 with with IN cord-325712-9kbnyqt3 89 15 the the DT cord-325712-9kbnyqt3 89 16 surface surface NN cord-325712-9kbnyqt3 89 17 of of IN cord-325712-9kbnyqt3 89 18 the the DT cord-325712-9kbnyqt3 89 19 cell cell NN cord-325712-9kbnyqt3 89 20 or or CC cord-325712-9kbnyqt3 89 21 extracellular extracellular JJ cord-325712-9kbnyqt3 89 22 environment environment NN cord-325712-9kbnyqt3 89 23 . . . cord-325712-9kbnyqt3 90 1 Tracking track VBG cord-325712-9kbnyqt3 90 2 frame frame NN cord-325712-9kbnyqt3 90 3 - - HYPH cord-325712-9kbnyqt3 90 4 to to IN cord-325712-9kbnyqt3 90 5 - - HYPH cord-325712-9kbnyqt3 90 6 frame frame NN cord-325712-9kbnyqt3 90 7 is be VBZ cord-325712-9kbnyqt3 90 8 important important JJ cord-325712-9kbnyqt3 90 9 in in IN cord-325712-9kbnyqt3 90 10 measuring measure VBG cord-325712-9kbnyqt3 90 11 binding bind VBG cord-325712-9kbnyqt3 90 12 residence residence NN cord-325712-9kbnyqt3 90 13 times time NNS cord-325712-9kbnyqt3 90 14 as as RB cord-325712-9kbnyqt3 90 15 well well RB cord-325712-9kbnyqt3 90 16 , , , cord-325712-9kbnyqt3 90 17 and and CC cord-325712-9kbnyqt3 90 18 by by IN cord-325712-9kbnyqt3 90 19 extension extension NN cord-325712-9kbnyqt3 90 20 , , , cord-325712-9kbnyqt3 90 21 binding bind VBG cord-325712-9kbnyqt3 90 22 strength strength NN cord-325712-9kbnyqt3 90 23 characteristics characteristic NNS cord-325712-9kbnyqt3 90 24 [ [ -LRB- cord-325712-9kbnyqt3 90 25 37 37 CD cord-325712-9kbnyqt3 90 26 ] ] -RRB- cord-325712-9kbnyqt3 90 27 . . . cord-325712-9kbnyqt3 91 1 Once once RB cord-325712-9kbnyqt3 91 2 bound bind VBN cord-325712-9kbnyqt3 91 3 , , , cord-325712-9kbnyqt3 91 4 the the DT cord-325712-9kbnyqt3 91 5 progression progression NN cord-325712-9kbnyqt3 91 6 of of IN cord-325712-9kbnyqt3 91 7 membrane membrane NN cord-325712-9kbnyqt3 91 8 fusion fusion NN cord-325712-9kbnyqt3 91 9 can can MD cord-325712-9kbnyqt3 91 10 be be VB cord-325712-9kbnyqt3 91 11 tracked track VBN cord-325712-9kbnyqt3 91 12 from from IN cord-325712-9kbnyqt3 91 13 frame frame NN cord-325712-9kbnyqt3 91 14 - - HYPH cord-325712-9kbnyqt3 91 15 to to IN cord-325712-9kbnyqt3 91 16 - - HYPH cord-325712-9kbnyqt3 91 17 frame frame NN cord-325712-9kbnyqt3 91 18 using use VBG cord-325712-9kbnyqt3 91 19 strategies strategy NNS cord-325712-9kbnyqt3 91 20 like like IN cord-325712-9kbnyqt3 91 21 fluorescence fluorescence NN cord-325712-9kbnyqt3 91 22 dequenching dequenching NN cord-325712-9kbnyqt3 91 23 , , , cord-325712-9kbnyqt3 91 24 where where WRB cord-325712-9kbnyqt3 91 25 the the DT cord-325712-9kbnyqt3 91 26 evolution evolution NN cord-325712-9kbnyqt3 91 27 of of IN cord-325712-9kbnyqt3 91 28 the the DT cord-325712-9kbnyqt3 91 29 fluorescence fluorescence NN cord-325712-9kbnyqt3 91 30 signal signal NN cord-325712-9kbnyqt3 91 31 reports report NNS cord-325712-9kbnyqt3 91 32 on on IN cord-325712-9kbnyqt3 91 33 the the DT cord-325712-9kbnyqt3 91 34 merging merging NN cord-325712-9kbnyqt3 91 35 of of IN cord-325712-9kbnyqt3 91 36 membranes membrane NNS cord-325712-9kbnyqt3 91 37 , , , cord-325712-9kbnyqt3 91 38 the the DT cord-325712-9kbnyqt3 91 39 rate rate NN cord-325712-9kbnyqt3 91 40 of of IN cord-325712-9kbnyqt3 91 41 membrane membrane NN cord-325712-9kbnyqt3 91 42 mixing mixing NN cord-325712-9kbnyqt3 91 43 , , , cord-325712-9kbnyqt3 91 44 and and CC cord-325712-9kbnyqt3 91 45 the the DT cord-325712-9kbnyqt3 91 46 release release NN cord-325712-9kbnyqt3 91 47 of of IN cord-325712-9kbnyqt3 91 48 viral viral JJ cord-325712-9kbnyqt3 91 49 genome genome NN cord-325712-9kbnyqt3 91 50 . . . cord-325712-9kbnyqt3 92 1 Finally finally RB cord-325712-9kbnyqt3 92 2 , , , cord-325712-9kbnyqt3 92 3 obtaining obtain VBG cord-325712-9kbnyqt3 92 4 good good JJ cord-325712-9kbnyqt3 92 5 statistical statistical JJ cord-325712-9kbnyqt3 92 6 data datum NNS cord-325712-9kbnyqt3 92 7 from from IN cord-325712-9kbnyqt3 92 8 virion virion NN cord-325712-9kbnyqt3 92 9 tracking tracking NN cord-325712-9kbnyqt3 92 10 experiments experiment NNS cord-325712-9kbnyqt3 92 11 requires require VBZ cord-325712-9kbnyqt3 92 12 collecting collect VBG cord-325712-9kbnyqt3 92 13 data datum NNS cord-325712-9kbnyqt3 92 14 on on IN cord-325712-9kbnyqt3 92 15 hundreds hundred NNS cord-325712-9kbnyqt3 92 16 of of IN cord-325712-9kbnyqt3 92 17 individual individual JJ cord-325712-9kbnyqt3 92 18 virions virion NNS cord-325712-9kbnyqt3 92 19 . . . cord-325712-9kbnyqt3 93 1 Single single JJ cord-325712-9kbnyqt3 93 2 virion virion NN cord-325712-9kbnyqt3 93 3 tracking tracking NN cord-325712-9kbnyqt3 93 4 may may MD cord-325712-9kbnyqt3 93 5 follow follow VB cord-325712-9kbnyqt3 93 6 virions virion NNS cord-325712-9kbnyqt3 93 7 through through IN cord-325712-9kbnyqt3 93 8 the the DT cord-325712-9kbnyqt3 93 9 infection infection NN cord-325712-9kbnyqt3 93 10 process process NN cord-325712-9kbnyqt3 93 11 in in IN cord-325712-9kbnyqt3 93 12 live live JJ cord-325712-9kbnyqt3 93 13 cells cell NNS cord-325712-9kbnyqt3 93 14 using use VBG cord-325712-9kbnyqt3 93 15 confocal confocal JJ cord-325712-9kbnyqt3 93 16 microscopy microscopy NNS cord-325712-9kbnyqt3 93 17 or or CC cord-325712-9kbnyqt3 93 18 within within IN cord-325712-9kbnyqt3 93 19 an an DT cord-325712-9kbnyqt3 93 20 in in FW cord-325712-9kbnyqt3 93 21 vitro vitro FW cord-325712-9kbnyqt3 93 22 biomimetic biomimetic JJ cord-325712-9kbnyqt3 93 23 platform platform NN cord-325712-9kbnyqt3 93 24 using use VBG cord-325712-9kbnyqt3 93 25 TIRF TIRF NNP cord-325712-9kbnyqt3 93 26 microscopy microscopy NN cord-325712-9kbnyqt3 93 27 . . . cord-325712-9kbnyqt3 94 1 Cell cell NN cord-325712-9kbnyqt3 94 2 - - HYPH cord-325712-9kbnyqt3 94 3 based base VBN cord-325712-9kbnyqt3 94 4 virion virion NN cord-325712-9kbnyqt3 94 5 imaging imaging NN cord-325712-9kbnyqt3 94 6 techniques technique NNS cord-325712-9kbnyqt3 94 7 enable enable VBP cord-325712-9kbnyqt3 94 8 direct direct JJ cord-325712-9kbnyqt3 94 9 visualization visualization NN cord-325712-9kbnyqt3 94 10 of of IN cord-325712-9kbnyqt3 94 11 the the DT cord-325712-9kbnyqt3 94 12 viral viral JJ cord-325712-9kbnyqt3 94 13 entry entry NN cord-325712-9kbnyqt3 94 14 pathway pathway NN cord-325712-9kbnyqt3 94 15 and and CC cord-325712-9kbnyqt3 94 16 interactions interaction NNS cord-325712-9kbnyqt3 94 17 between between IN cord-325712-9kbnyqt3 94 18 virions virion NNS cord-325712-9kbnyqt3 94 19 and and CC cord-325712-9kbnyqt3 94 20 host host NN cord-325712-9kbnyqt3 94 21 cell cell NN cord-325712-9kbnyqt3 94 22 machinery machinery NN cord-325712-9kbnyqt3 94 23 within within IN cord-325712-9kbnyqt3 94 24 the the DT cord-325712-9kbnyqt3 94 25 native native JJ cord-325712-9kbnyqt3 94 26 complexity complexity NN cord-325712-9kbnyqt3 94 27 of of IN cord-325712-9kbnyqt3 94 28 the the DT cord-325712-9kbnyqt3 94 29 cellular cellular JJ cord-325712-9kbnyqt3 94 30 environment environment NN cord-325712-9kbnyqt3 94 31 . . . cord-325712-9kbnyqt3 95 1 On on IN cord-325712-9kbnyqt3 95 2 the the DT cord-325712-9kbnyqt3 95 3 other other JJ cord-325712-9kbnyqt3 95 4 hand hand NN cord-325712-9kbnyqt3 95 5 , , , cord-325712-9kbnyqt3 95 6 biomimetic biomimetic JJ cord-325712-9kbnyqt3 95 7 platforms platform NNS cord-325712-9kbnyqt3 95 8 utilizing utilize VBG cord-325712-9kbnyqt3 95 9 the the DT cord-325712-9kbnyqt3 95 10 TIRF TIRF NNP cord-325712-9kbnyqt3 95 11 configuration configuration NN cord-325712-9kbnyqt3 95 12 enable enable VB cord-325712-9kbnyqt3 95 13 observation observation NN cord-325712-9kbnyqt3 95 14 of of IN cord-325712-9kbnyqt3 95 15 membrane membrane NN cord-325712-9kbnyqt3 95 16 surface surface NN cord-325712-9kbnyqt3 95 17 phenomena phenomenon NNS cord-325712-9kbnyqt3 95 18 and and CC cord-325712-9kbnyqt3 95 19 can can MD cord-325712-9kbnyqt3 95 20 be be VB cord-325712-9kbnyqt3 95 21 integrated integrate VBN cord-325712-9kbnyqt3 95 22 with with IN cord-325712-9kbnyqt3 95 23 tools tool NNS cord-325712-9kbnyqt3 95 24 like like IN cord-325712-9kbnyqt3 95 25 microfluidics microfluidic NNS cord-325712-9kbnyqt3 95 26 that that WDT cord-325712-9kbnyqt3 95 27 allow allow VBP cord-325712-9kbnyqt3 95 28 the the DT cord-325712-9kbnyqt3 95 29 user user NN cord-325712-9kbnyqt3 95 30 to to TO cord-325712-9kbnyqt3 95 31 define define VB cord-325712-9kbnyqt3 95 32 and and CC cord-325712-9kbnyqt3 95 33 test test VB cord-325712-9kbnyqt3 95 34 a a DT cord-325712-9kbnyqt3 95 35 tightly tightly RB cord-325712-9kbnyqt3 95 36 controlled control VBN cord-325712-9kbnyqt3 95 37 environment environment NN cord-325712-9kbnyqt3 95 38 . . . cord-325712-9kbnyqt3 96 1 This this DT cord-325712-9kbnyqt3 96 2 control control NN cord-325712-9kbnyqt3 96 3 enables enable VBZ cord-325712-9kbnyqt3 96 4 decoupling decoupling NN cord-325712-9kbnyqt3 96 5 of of IN cord-325712-9kbnyqt3 96 6 factors factor NNS cord-325712-9kbnyqt3 96 7 that that WDT cord-325712-9kbnyqt3 96 8 may may MD cord-325712-9kbnyqt3 96 9 be be VB cord-325712-9kbnyqt3 96 10 hard hard JJ cord-325712-9kbnyqt3 96 11 to to TO cord-325712-9kbnyqt3 96 12 detangle detangle VB cord-325712-9kbnyqt3 96 13 in in IN cord-325712-9kbnyqt3 96 14 vivo vivo NN cord-325712-9kbnyqt3 96 15 . . . cord-325712-9kbnyqt3 97 1 Sections section NNS cord-325712-9kbnyqt3 97 2 2.2.2.1 2.2.2.1 CD cord-325712-9kbnyqt3 97 3 and and CC cord-325712-9kbnyqt3 97 4 2.2.2.2 2.2.2.2 CD cord-325712-9kbnyqt3 97 5 provide provide VB cord-325712-9kbnyqt3 97 6 overviews overview NNS cord-325712-9kbnyqt3 97 7 of of IN cord-325712-9kbnyqt3 97 8 these these DT cord-325712-9kbnyqt3 97 9 two two CD cord-325712-9kbnyqt3 97 10 approaches approach NNS cord-325712-9kbnyqt3 97 11 while while IN cord-325712-9kbnyqt3 97 12 Sect Sect NNP cord-325712-9kbnyqt3 97 13 . . . cord-325712-9kbnyqt3 98 1 2.3 2.3 CD cord-325712-9kbnyqt3 98 2 provides provide VBZ cord-325712-9kbnyqt3 98 3 examples example NNS cord-325712-9kbnyqt3 98 4 of of IN cord-325712-9kbnyqt3 98 5 specific specific JJ cord-325712-9kbnyqt3 98 6 implementations implementation NNS cord-325712-9kbnyqt3 98 7 of of IN cord-325712-9kbnyqt3 98 8 single single JJ cord-325712-9kbnyqt3 98 9 virion virion NN cord-325712-9kbnyqt3 98 10 tracking tracking NN cord-325712-9kbnyqt3 98 11 to to IN cord-325712-9kbnyqt3 98 12 the the DT cord-325712-9kbnyqt3 98 13 investigation investigation NN cord-325712-9kbnyqt3 98 14 of of IN cord-325712-9kbnyqt3 98 15 viral viral JJ cord-325712-9kbnyqt3 98 16 entry entry NN cord-325712-9kbnyqt3 98 17 and and CC cord-325712-9kbnyqt3 98 18 contrasts contrast VBZ cord-325712-9kbnyqt3 98 19 them -PRON- PRP cord-325712-9kbnyqt3 98 20 with with IN cord-325712-9kbnyqt3 98 21 ensemble ensemble NN cord-325712-9kbnyqt3 98 22 approaches approach NNS cord-325712-9kbnyqt3 98 23 . . . cord-325712-9kbnyqt3 99 1 In in IN cord-325712-9kbnyqt3 99 2 current current JJ cord-325712-9kbnyqt3 99 3 cell cell NN cord-325712-9kbnyqt3 99 4 - - HYPH cord-325712-9kbnyqt3 99 5 based base VBN cord-325712-9kbnyqt3 99 6 fluorescence fluorescence NN cord-325712-9kbnyqt3 99 7 assays assay NNS cord-325712-9kbnyqt3 99 8 , , , cord-325712-9kbnyqt3 99 9 both both DT cord-325712-9kbnyqt3 99 10 virions virion NNS cord-325712-9kbnyqt3 99 11 and and CC cord-325712-9kbnyqt3 99 12 cellular cellular JJ cord-325712-9kbnyqt3 99 13 components component NNS cord-325712-9kbnyqt3 99 14 are be VBP cord-325712-9kbnyqt3 99 15 fluorescently fluorescently RB cord-325712-9kbnyqt3 99 16 labeled label VBN cord-325712-9kbnyqt3 99 17 so so IN cord-325712-9kbnyqt3 99 18 their -PRON- PRP$ cord-325712-9kbnyqt3 99 19 interactions interaction NNS cord-325712-9kbnyqt3 99 20 can can MD cord-325712-9kbnyqt3 99 21 be be VB cord-325712-9kbnyqt3 99 22 tracked track VBN cord-325712-9kbnyqt3 99 23 with with IN cord-325712-9kbnyqt3 99 24 multicolor multicolor JJ cord-325712-9kbnyqt3 99 25 real real JJ cord-325712-9kbnyqt3 99 26 - - HYPH cord-325712-9kbnyqt3 99 27 time time NN cord-325712-9kbnyqt3 99 28 microscopy microscopy NN cord-325712-9kbnyqt3 99 29 . . . cord-325712-9kbnyqt3 100 1 Live live JJ cord-325712-9kbnyqt3 100 2 cell cell NN cord-325712-9kbnyqt3 100 3 virion virion NN cord-325712-9kbnyqt3 100 4 tracking tracking NN cord-325712-9kbnyqt3 100 5 can can MD cord-325712-9kbnyqt3 100 6 be be VB cord-325712-9kbnyqt3 100 7 used use VBN cord-325712-9kbnyqt3 100 8 to to TO cord-325712-9kbnyqt3 100 9 observe observe VB cord-325712-9kbnyqt3 100 10 cell cell NN cord-325712-9kbnyqt3 100 11 - - HYPH cord-325712-9kbnyqt3 100 12 cell cell NN cord-325712-9kbnyqt3 100 13 spread spread NN cord-325712-9kbnyqt3 100 14 , , , cord-325712-9kbnyqt3 100 15 receptor receptor NN cord-325712-9kbnyqt3 100 16 binding binding NN cord-325712-9kbnyqt3 100 17 , , , cord-325712-9kbnyqt3 100 18 intracellular intracellular JJ cord-325712-9kbnyqt3 100 19 trafficking trafficking NN cord-325712-9kbnyqt3 100 20 and and CC cord-325712-9kbnyqt3 100 21 membrane membrane NN cord-325712-9kbnyqt3 100 22 fusion fusion NN cord-325712-9kbnyqt3 100 23 . . . cord-325712-9kbnyqt3 101 1 Virions Virions NNP cord-325712-9kbnyqt3 101 2 may may MD cord-325712-9kbnyqt3 101 3 be be VB cord-325712-9kbnyqt3 101 4 labeled label VBN cord-325712-9kbnyqt3 101 5 with with IN cord-325712-9kbnyqt3 101 6 fluorescent fluorescent JJ cord-325712-9kbnyqt3 101 7 proteins protein NNS cord-325712-9kbnyqt3 101 8 , , , cord-325712-9kbnyqt3 101 9 chemical chemical NN cord-325712-9kbnyqt3 101 10 dyes dye NNS cord-325712-9kbnyqt3 101 11 , , , cord-325712-9kbnyqt3 101 12 or or CC cord-325712-9kbnyqt3 101 13 quantum quantum NN cord-325712-9kbnyqt3 101 14 dots dot NNS cord-325712-9kbnyqt3 101 15 while while IN cord-325712-9kbnyqt3 101 16 intracellular intracellular JJ cord-325712-9kbnyqt3 101 17 components component NNS cord-325712-9kbnyqt3 101 18 are be VBP cord-325712-9kbnyqt3 101 19 typically typically RB cord-325712-9kbnyqt3 101 20 labeled label VBN cord-325712-9kbnyqt3 101 21 using use VBG cord-325712-9kbnyqt3 101 22 fluorescent fluorescent NN cord-325712-9kbnyqt3 101 23 proteins protein NNS cord-325712-9kbnyqt3 101 24 . . . cord-325712-9kbnyqt3 102 1 Epifluorescence Epifluorescence NNP cord-325712-9kbnyqt3 102 2 , , , cord-325712-9kbnyqt3 102 3 TIRF TIRF NNP cord-325712-9kbnyqt3 102 4 , , , cord-325712-9kbnyqt3 102 5 and and CC cord-325712-9kbnyqt3 102 6 confocal confocal JJ cord-325712-9kbnyqt3 102 7 microscopy microscopy NNS cord-325712-9kbnyqt3 102 8 have have VBP cord-325712-9kbnyqt3 102 9 all all DT cord-325712-9kbnyqt3 102 10 been be VBN cord-325712-9kbnyqt3 102 11 used use VBN cord-325712-9kbnyqt3 102 12 in in IN cord-325712-9kbnyqt3 102 13 live live JJ cord-325712-9kbnyqt3 102 14 cell cell NN cord-325712-9kbnyqt3 102 15 single single JJ cord-325712-9kbnyqt3 102 16 virion virion NN cord-325712-9kbnyqt3 102 17 tracking tracking NN cord-325712-9kbnyqt3 102 18 . . . cord-325712-9kbnyqt3 103 1 Virions Virions NNP cord-325712-9kbnyqt3 103 2 may may MD cord-325712-9kbnyqt3 103 3 be be VB cord-325712-9kbnyqt3 103 4 tracked track VBN cord-325712-9kbnyqt3 103 5 in in IN cord-325712-9kbnyqt3 103 6 two two CD cord-325712-9kbnyqt3 103 7 or or CC cord-325712-9kbnyqt3 103 8 three three CD cord-325712-9kbnyqt3 103 9 dimensions dimension NNS cord-325712-9kbnyqt3 103 10 depending depend VBG cord-325712-9kbnyqt3 103 11 on on IN cord-325712-9kbnyqt3 103 12 the the DT cord-325712-9kbnyqt3 103 13 microscope microscope NN cord-325712-9kbnyqt3 103 14 configuration configuration NN cord-325712-9kbnyqt3 103 15 , , , cord-325712-9kbnyqt3 103 16 as as IN cord-325712-9kbnyqt3 103 17 described describe VBN cord-325712-9kbnyqt3 103 18 above above RB cord-325712-9kbnyqt3 103 19 . . . cord-325712-9kbnyqt3 104 1 Certain certain JJ cord-325712-9kbnyqt3 104 2 cell cell NN cord-325712-9kbnyqt3 104 3 types type NNS cord-325712-9kbnyqt3 104 4 may may MD cord-325712-9kbnyqt3 104 5 be be VB cord-325712-9kbnyqt3 104 6 easier easy JJR cord-325712-9kbnyqt3 104 7 to to TO cord-325712-9kbnyqt3 104 8 image image VB cord-325712-9kbnyqt3 104 9 due due IN cord-325712-9kbnyqt3 104 10 to to IN cord-325712-9kbnyqt3 104 11 autofluorescence autofluorescence NNP cord-325712-9kbnyqt3 104 12 of of IN cord-325712-9kbnyqt3 104 13 cellular cellular JJ cord-325712-9kbnyqt3 104 14 components component NNS cord-325712-9kbnyqt3 104 15 [ [ -LRB- cord-325712-9kbnyqt3 104 16 11 11 CD cord-325712-9kbnyqt3 104 17 ] ] -RRB- cord-325712-9kbnyqt3 104 18 . . . cord-325712-9kbnyqt3 105 1 As as RB cord-325712-9kbnyqt3 105 2 early early RB cord-325712-9kbnyqt3 105 3 as as IN cord-325712-9kbnyqt3 105 4 the the DT cord-325712-9kbnyqt3 105 5 1980s 1980 NNS cord-325712-9kbnyqt3 105 6 , , , cord-325712-9kbnyqt3 105 7 fusion fusion NN cord-325712-9kbnyqt3 105 8 of of IN cord-325712-9kbnyqt3 105 9 individual individual JJ cord-325712-9kbnyqt3 105 10 virions virion NNS cord-325712-9kbnyqt3 105 11 at at IN cord-325712-9kbnyqt3 105 12 the the DT cord-325712-9kbnyqt3 105 13 plasma plasma NN cord-325712-9kbnyqt3 105 14 membrane membrane NN cord-325712-9kbnyqt3 105 15 surface surface NN cord-325712-9kbnyqt3 105 16 was be VBD cord-325712-9kbnyqt3 105 17 observed observe VBN cord-325712-9kbnyqt3 105 18 . . . cord-325712-9kbnyqt3 106 1 Virions virion NNS cord-325712-9kbnyqt3 106 2 were be VBD cord-325712-9kbnyqt3 106 3 labeled label VBN cord-325712-9kbnyqt3 106 4 with with IN cord-325712-9kbnyqt3 106 5 R18 R18 NNP cord-325712-9kbnyqt3 106 6 , , , cord-325712-9kbnyqt3 106 7 which which WDT cord-325712-9kbnyqt3 106 8 self self NN cord-325712-9kbnyqt3 106 9 - - HYPH cord-325712-9kbnyqt3 106 10 quenches quench VBZ cord-325712-9kbnyqt3 106 11 at at IN cord-325712-9kbnyqt3 106 12 high high JJ cord-325712-9kbnyqt3 106 13 concentrations concentration NNS cord-325712-9kbnyqt3 106 14 , , , cord-325712-9kbnyqt3 106 15 and and CC cord-325712-9kbnyqt3 106 16 dequenching dequenching NN cord-325712-9kbnyqt3 106 17 of of IN cord-325712-9kbnyqt3 106 18 the the DT cord-325712-9kbnyqt3 106 19 R18 R18 NNP cord-325712-9kbnyqt3 106 20 upon upon IN cord-325712-9kbnyqt3 106 21 fusion fusion NN cord-325712-9kbnyqt3 106 22 of of IN cord-325712-9kbnyqt3 106 23 the the DT cord-325712-9kbnyqt3 106 24 virion virion NN cord-325712-9kbnyqt3 106 25 with with IN cord-325712-9kbnyqt3 106 26 a a DT cord-325712-9kbnyqt3 106 27 membrane membrane NN cord-325712-9kbnyqt3 106 28 was be VBD cord-325712-9kbnyqt3 106 29 detected detect VBN cord-325712-9kbnyqt3 106 30 by by IN cord-325712-9kbnyqt3 106 31 a a DT cord-325712-9kbnyqt3 106 32 simple simple JJ cord-325712-9kbnyqt3 106 33 fluorescence fluorescence NN cord-325712-9kbnyqt3 106 34 microscope microscope NN cord-325712-9kbnyqt3 106 35 . . . cord-325712-9kbnyqt3 107 1 Early early JJ cord-325712-9kbnyqt3 107 2 assays assay NNS cord-325712-9kbnyqt3 107 3 monitored monitor VBD cord-325712-9kbnyqt3 107 4 fusion fusion NN cord-325712-9kbnyqt3 107 5 at at IN cord-325712-9kbnyqt3 107 6 the the DT cord-325712-9kbnyqt3 107 7 plasma plasma NN cord-325712-9kbnyqt3 107 8 membrane membrane NN cord-325712-9kbnyqt3 107 9 of of IN cord-325712-9kbnyqt3 107 10 erythrocytes erythrocyte NNS cord-325712-9kbnyqt3 107 11 , , , cord-325712-9kbnyqt3 107 12 where where WRB cord-325712-9kbnyqt3 107 13 fusion fusion NN cord-325712-9kbnyqt3 107 14 of of IN cord-325712-9kbnyqt3 107 15 influenza influenza NN cord-325712-9kbnyqt3 107 16 could could MD cord-325712-9kbnyqt3 107 17 be be VB cord-325712-9kbnyqt3 107 18 triggered trigger VBN cord-325712-9kbnyqt3 107 19 by by IN cord-325712-9kbnyqt3 107 20 lowering lower VBG cord-325712-9kbnyqt3 107 21 the the DT cord-325712-9kbnyqt3 107 22 pH pH NNP cord-325712-9kbnyqt3 107 23 [ [ -LRB- cord-325712-9kbnyqt3 107 24 42 42 CD cord-325712-9kbnyqt3 107 25 , , , cord-325712-9kbnyqt3 107 26 43 43 CD cord-325712-9kbnyqt3 107 27 ] ] -RRB- cord-325712-9kbnyqt3 107 28 . . . cord-325712-9kbnyqt3 108 1 An an DT cord-325712-9kbnyqt3 108 2 important important JJ cord-325712-9kbnyqt3 108 3 aspect aspect NN cord-325712-9kbnyqt3 108 4 of of IN cord-325712-9kbnyqt3 108 5 live live JJ cord-325712-9kbnyqt3 108 6 cell cell NN cord-325712-9kbnyqt3 108 7 approaches approach NNS cord-325712-9kbnyqt3 108 8 is be VBZ cord-325712-9kbnyqt3 108 9 that that IN cord-325712-9kbnyqt3 108 10 it -PRON- PRP cord-325712-9kbnyqt3 108 11 is be VBZ cord-325712-9kbnyqt3 108 12 possible possible JJ cord-325712-9kbnyqt3 108 13 to to TO cord-325712-9kbnyqt3 108 14 inhibit inhibit VB cord-325712-9kbnyqt3 108 15 cellular cellular JJ cord-325712-9kbnyqt3 108 16 machinery machinery NN cord-325712-9kbnyqt3 108 17 by by IN cord-325712-9kbnyqt3 108 18 drug drug NN cord-325712-9kbnyqt3 108 19 treatment treatment NN cord-325712-9kbnyqt3 108 20 or or CC cord-325712-9kbnyqt3 108 21 gene gene NN cord-325712-9kbnyqt3 108 22 knockout knockout NN cord-325712-9kbnyqt3 108 23 . . . cord-325712-9kbnyqt3 109 1 Such such JJ cord-325712-9kbnyqt3 109 2 cells cell NNS cord-325712-9kbnyqt3 109 3 can can MD cord-325712-9kbnyqt3 109 4 be be VB cord-325712-9kbnyqt3 109 5 used use VBN cord-325712-9kbnyqt3 109 6 in in IN cord-325712-9kbnyqt3 109 7 combination combination NN cord-325712-9kbnyqt3 109 8 with with IN cord-325712-9kbnyqt3 109 9 live live JJ cord-325712-9kbnyqt3 109 10 cell cell NN cord-325712-9kbnyqt3 109 11 imaging imaging NN cord-325712-9kbnyqt3 109 12 to to TO cord-325712-9kbnyqt3 109 13 identify identify VB cord-325712-9kbnyqt3 109 14 key key JJ cord-325712-9kbnyqt3 109 15 cellular cellular JJ cord-325712-9kbnyqt3 109 16 components component NNS cord-325712-9kbnyqt3 109 17 that that WDT cord-325712-9kbnyqt3 109 18 are be VBP cord-325712-9kbnyqt3 109 19 necessary necessary JJ cord-325712-9kbnyqt3 109 20 for for IN cord-325712-9kbnyqt3 109 21 virus virus NN cord-325712-9kbnyqt3 109 22 entry entry NN cord-325712-9kbnyqt3 109 23 . . . cord-325712-9kbnyqt3 110 1 A a DT cord-325712-9kbnyqt3 110 2 review review NN cord-325712-9kbnyqt3 110 3 of of IN cord-325712-9kbnyqt3 110 4 implementations implementation NNS cord-325712-9kbnyqt3 110 5 and and CC cord-325712-9kbnyqt3 110 6 insights insight NNS cord-325712-9kbnyqt3 110 7 gained gain VBD cord-325712-9kbnyqt3 110 8 from from IN cord-325712-9kbnyqt3 110 9 live live JJ cord-325712-9kbnyqt3 110 10 cell cell NN cord-325712-9kbnyqt3 110 11 single single JJ cord-325712-9kbnyqt3 110 12 virion virion NN cord-325712-9kbnyqt3 110 13 imaging imaging NN cord-325712-9kbnyqt3 110 14 will will MD cord-325712-9kbnyqt3 110 15 be be VB cord-325712-9kbnyqt3 110 16 provided provide VBN cord-325712-9kbnyqt3 110 17 in in IN cord-325712-9kbnyqt3 110 18 Sect Sect NNP cord-325712-9kbnyqt3 110 19 . . . cord-325712-9kbnyqt3 111 1 2.3 2.3 CD cord-325712-9kbnyqt3 111 2 . . . cord-325712-9kbnyqt3 112 1 We -PRON- PRP cord-325712-9kbnyqt3 112 2 also also RB cord-325712-9kbnyqt3 112 3 recommend recommend VBP cord-325712-9kbnyqt3 112 4 the the DT cord-325712-9kbnyqt3 112 5 reviews review NNS cord-325712-9kbnyqt3 112 6 by by IN cord-325712-9kbnyqt3 112 7 Brandenburg Brandenburg NNP cord-325712-9kbnyqt3 112 8 and and CC cord-325712-9kbnyqt3 112 9 Zhuang Zhuang NNP cord-325712-9kbnyqt3 112 10 [ [ -LRB- cord-325712-9kbnyqt3 112 11 14 14 CD cord-325712-9kbnyqt3 112 12 ] ] -RRB- cord-325712-9kbnyqt3 112 13 , , , cord-325712-9kbnyqt3 112 14 Ewers Ewers NNPS cord-325712-9kbnyqt3 112 15 and and CC cord-325712-9kbnyqt3 112 16 Schelhaas Schelhaas NNP cord-325712-9kbnyqt3 112 17 [ [ -LRB- cord-325712-9kbnyqt3 112 18 20 20 CD cord-325712-9kbnyqt3 112 19 ] ] -RRB- cord-325712-9kbnyqt3 112 20 , , , cord-325712-9kbnyqt3 112 21 Otterstrom Otterstrom NNP cord-325712-9kbnyqt3 112 22 and and CC cord-325712-9kbnyqt3 112 23 Van Van NNP cord-325712-9kbnyqt3 112 24 Oijen Oijen NNP cord-325712-9kbnyqt3 112 25 [ [ -LRB- cord-325712-9kbnyqt3 112 26 22 22 CD cord-325712-9kbnyqt3 112 27 ] ] -RRB- cord-325712-9kbnyqt3 112 28 , , , cord-325712-9kbnyqt3 112 29 Sun Sun NNP cord-325712-9kbnyqt3 112 30 et et NNP cord-325712-9kbnyqt3 112 31 al al NNP cord-325712-9kbnyqt3 112 32 . . . cord-325712-9kbnyqt3 113 1 [ [ -LRB- cord-325712-9kbnyqt3 113 2 23 23 CD cord-325712-9kbnyqt3 113 3 ] ] -RRB- cord-325712-9kbnyqt3 113 4 , , , cord-325712-9kbnyqt3 113 5 and and CC cord-325712-9kbnyqt3 113 6 Wang Wang NNP cord-325712-9kbnyqt3 113 7 et et NNP cord-325712-9kbnyqt3 113 8 al al NNP cord-325712-9kbnyqt3 113 9 . . . cord-325712-9kbnyqt3 114 1 [ [ -LRB- cord-325712-9kbnyqt3 114 2 29 29 CD cord-325712-9kbnyqt3 114 3 ] ] -RRB- cord-325712-9kbnyqt3 114 4 . . . cord-325712-9kbnyqt3 115 1 In in IN cord-325712-9kbnyqt3 115 2 early early JJ cord-325712-9kbnyqt3 115 3 work work NN cord-325712-9kbnyqt3 115 4 , , , cord-325712-9kbnyqt3 115 5 perhaps perhaps RB cord-325712-9kbnyqt3 115 6 the the DT cord-325712-9kbnyqt3 115 7 first first JJ cord-325712-9kbnyqt3 115 8 , , , cord-325712-9kbnyqt3 115 9 observations observation NNS cord-325712-9kbnyqt3 115 10 of of IN cord-325712-9kbnyqt3 115 11 membrane membrane NN cord-325712-9kbnyqt3 115 12 fusion fusion NN cord-325712-9kbnyqt3 115 13 of of IN cord-325712-9kbnyqt3 115 14 individual individual JJ cord-325712-9kbnyqt3 115 15 virions virion NNS cord-325712-9kbnyqt3 115 16 to to IN cord-325712-9kbnyqt3 115 17 biomimetic biomimetic JJ cord-325712-9kbnyqt3 115 18 membranes membrane NNS cord-325712-9kbnyqt3 115 19 was be VBD cord-325712-9kbnyqt3 115 20 monitored monitor VBN cord-325712-9kbnyqt3 115 21 with with IN cord-325712-9kbnyqt3 115 22 video video NN cord-325712-9kbnyqt3 115 23 fluorescence fluorescence NN cord-325712-9kbnyqt3 115 24 microscopy microscopy NN cord-325712-9kbnyqt3 115 25 [ [ -LRB- cord-325712-9kbnyqt3 115 26 44 44 CD cord-325712-9kbnyqt3 115 27 , , , cord-325712-9kbnyqt3 115 28 45 45 CD cord-325712-9kbnyqt3 115 29 ] ] -RRB- cord-325712-9kbnyqt3 115 30 . . . cord-325712-9kbnyqt3 116 1 In in IN cord-325712-9kbnyqt3 116 2 this this DT cord-325712-9kbnyqt3 116 3 work work NN cord-325712-9kbnyqt3 116 4 , , , cord-325712-9kbnyqt3 116 5 planar planar JJ cord-325712-9kbnyqt3 116 6 bilayers bilayer NNS cord-325712-9kbnyqt3 116 7 were be VBD cord-325712-9kbnyqt3 116 8 suspended suspend VBN cord-325712-9kbnyqt3 116 9 over over IN cord-325712-9kbnyqt3 116 10 a a DT cord-325712-9kbnyqt3 116 11 small small JJ cord-325712-9kbnyqt3 116 12 hole hole NN cord-325712-9kbnyqt3 116 13 in in IN cord-325712-9kbnyqt3 116 14 a a DT cord-325712-9kbnyqt3 116 15 Teflon Teflon NNP cord-325712-9kbnyqt3 116 16 sheet sheet NN cord-325712-9kbnyqt3 116 17 , , , cord-325712-9kbnyqt3 116 18 a a DT cord-325712-9kbnyqt3 116 19 so so RB cord-325712-9kbnyqt3 116 20 - - HYPH cord-325712-9kbnyqt3 116 21 called call VBN cord-325712-9kbnyqt3 116 22 black black JJ cord-325712-9kbnyqt3 116 23 lipid lipid NN cord-325712-9kbnyqt3 116 24 membrane membrane NN cord-325712-9kbnyqt3 116 25 ( ( -LRB- cord-325712-9kbnyqt3 116 26 BLM BLM NNP cord-325712-9kbnyqt3 116 27 ) ) -RRB- cord-325712-9kbnyqt3 116 28 , , , cord-325712-9kbnyqt3 116 29 to to TO cord-325712-9kbnyqt3 116 30 serve serve VB cord-325712-9kbnyqt3 116 31 as as IN cord-325712-9kbnyqt3 116 32 the the DT cord-325712-9kbnyqt3 116 33 host host NN cord-325712-9kbnyqt3 116 34 cell cell NN cord-325712-9kbnyqt3 116 35 membrane membrane NN cord-325712-9kbnyqt3 116 36 mimic mimic VBP cord-325712-9kbnyqt3 116 37 . . . cord-325712-9kbnyqt3 117 1 However however RB cord-325712-9kbnyqt3 117 2 , , , cord-325712-9kbnyqt3 117 3 BLMs blm NNS cord-325712-9kbnyqt3 117 4 are be VBP cord-325712-9kbnyqt3 117 5 fragile fragile JJ cord-325712-9kbnyqt3 117 6 and and CC cord-325712-9kbnyqt3 117 7 prone prone JJ cord-325712-9kbnyqt3 117 8 to to TO cord-325712-9kbnyqt3 117 9 rupture rupture VB cord-325712-9kbnyqt3 117 10 and and CC cord-325712-9kbnyqt3 117 11 continued continued JJ cord-325712-9kbnyqt3 117 12 progress progress NN cord-325712-9kbnyqt3 117 13 using use VBG cord-325712-9kbnyqt3 117 14 this this DT cord-325712-9kbnyqt3 117 15 approach approach NN cord-325712-9kbnyqt3 117 16 was be VBD cord-325712-9kbnyqt3 117 17 slow slow JJ cord-325712-9kbnyqt3 117 18 . . . cord-325712-9kbnyqt3 118 1 In in IN cord-325712-9kbnyqt3 118 2 recent recent JJ cord-325712-9kbnyqt3 118 3 years year NNS cord-325712-9kbnyqt3 118 4 , , , cord-325712-9kbnyqt3 118 5 supported support VBD cord-325712-9kbnyqt3 118 6 lipid lipid NN cord-325712-9kbnyqt3 118 7 bilayers bilayer NNS cord-325712-9kbnyqt3 118 8 , , , cord-325712-9kbnyqt3 118 9 which which WDT cord-325712-9kbnyqt3 118 10 are be VBP cord-325712-9kbnyqt3 118 11 more more RBR cord-325712-9kbnyqt3 118 12 robust robust JJ cord-325712-9kbnyqt3 118 13 than than IN cord-325712-9kbnyqt3 118 14 BLMs blm NNS cord-325712-9kbnyqt3 118 15 , , , cord-325712-9kbnyqt3 118 16 have have VBP cord-325712-9kbnyqt3 118 17 become become VBN cord-325712-9kbnyqt3 118 18 more more RBR cord-325712-9kbnyqt3 118 19 widely widely RB cord-325712-9kbnyqt3 118 20 used use VBN cord-325712-9kbnyqt3 118 21 in in RP cord-325712-9kbnyqt3 118 22 in in IN cord-325712-9kbnyqt3 118 23 vitro vitro FW cord-325712-9kbnyqt3 118 24 single single JJ cord-325712-9kbnyqt3 118 25 virion virion NN cord-325712-9kbnyqt3 118 26 tracking track VBG cord-325712-9kbnyqt3 118 27 experiments experiment NNS cord-325712-9kbnyqt3 118 28 . . . cord-325712-9kbnyqt3 119 1 Because because IN cord-325712-9kbnyqt3 119 2 these these DT cord-325712-9kbnyqt3 119 3 SLB SLB NNP cord-325712-9kbnyqt3 119 4 platforms platform NNS cord-325712-9kbnyqt3 119 5 are be VBP cord-325712-9kbnyqt3 119 6 becoming become VBG cord-325712-9kbnyqt3 119 7 the the DT cord-325712-9kbnyqt3 119 8 backbone backbone NN cord-325712-9kbnyqt3 119 9 of of IN cord-325712-9kbnyqt3 119 10 many many JJ cord-325712-9kbnyqt3 119 11 types type NNS cord-325712-9kbnyqt3 119 12 of of IN cord-325712-9kbnyqt3 119 13 single single JJ cord-325712-9kbnyqt3 119 14 virion virion NN cord-325712-9kbnyqt3 119 15 tracking track VBG cord-325712-9kbnyqt3 119 16 experiments experiment NNS cord-325712-9kbnyqt3 119 17 , , , cord-325712-9kbnyqt3 119 18 it -PRON- PRP cord-325712-9kbnyqt3 119 19 is be VBZ cord-325712-9kbnyqt3 119 20 worth worth JJ cord-325712-9kbnyqt3 119 21 describing describe VBG cord-325712-9kbnyqt3 119 22 them -PRON- PRP cord-325712-9kbnyqt3 119 23 in in IN cord-325712-9kbnyqt3 119 24 some some DT cord-325712-9kbnyqt3 119 25 detail detail NN cord-325712-9kbnyqt3 119 26 here here RB cord-325712-9kbnyqt3 119 27 . . . cord-325712-9kbnyqt3 120 1 A a DT cord-325712-9kbnyqt3 120 2 supported supported JJ cord-325712-9kbnyqt3 120 3 lipid lipid NN cord-325712-9kbnyqt3 120 4 bilayer bilayer NN cord-325712-9kbnyqt3 120 5 is be VBZ cord-325712-9kbnyqt3 120 6 a a DT cord-325712-9kbnyqt3 120 7 planar planar JJ cord-325712-9kbnyqt3 120 8 , , , cord-325712-9kbnyqt3 120 9 single single JJ cord-325712-9kbnyqt3 120 10 bilayer bilayer NN cord-325712-9kbnyqt3 120 11 , , , cord-325712-9kbnyqt3 120 12 typically typically RB cord-325712-9kbnyqt3 120 13 self self NN cord-325712-9kbnyqt3 120 14 - - HYPH cord-325712-9kbnyqt3 120 15 assembled assemble VBN cord-325712-9kbnyqt3 120 16 by by IN cord-325712-9kbnyqt3 120 17 rupturing rupture VBG cord-325712-9kbnyqt3 120 18 liposomes liposome NNS cord-325712-9kbnyqt3 120 19 at at IN cord-325712-9kbnyqt3 120 20 the the DT cord-325712-9kbnyqt3 120 21 surface surface NN cord-325712-9kbnyqt3 120 22 of of IN cord-325712-9kbnyqt3 120 23 hydrophilic hydrophilic JJ cord-325712-9kbnyqt3 120 24 silica silica NN cord-325712-9kbnyqt3 120 25 surfaces surface NNS cord-325712-9kbnyqt3 120 26 like like IN cord-325712-9kbnyqt3 120 27 glass glass NN cord-325712-9kbnyqt3 120 28 microscope microscope NN cord-325712-9kbnyqt3 120 29 slides slide NNS cord-325712-9kbnyqt3 120 30 . . . cord-325712-9kbnyqt3 121 1 For for IN cord-325712-9kbnyqt3 121 2 reviews review NNS cord-325712-9kbnyqt3 121 3 of of IN cord-325712-9kbnyqt3 121 4 supported support VBN cord-325712-9kbnyqt3 121 5 lipid lipid NN cord-325712-9kbnyqt3 121 6 bilayer bilayer NN cord-325712-9kbnyqt3 121 7 technologies technology NNS cord-325712-9kbnyqt3 121 8 , , , cord-325712-9kbnyqt3 121 9 we -PRON- PRP cord-325712-9kbnyqt3 121 10 encourage encourage VBP cord-325712-9kbnyqt3 121 11 the the DT cord-325712-9kbnyqt3 121 12 reader reader NN cord-325712-9kbnyqt3 121 13 to to TO cord-325712-9kbnyqt3 121 14 consult consult VB cord-325712-9kbnyqt3 121 15 Sackmann Sackmann NNP cord-325712-9kbnyqt3 121 16 [ [ -LRB- cord-325712-9kbnyqt3 121 17 46 46 CD cord-325712-9kbnyqt3 121 18 ] ] -RRB- cord-325712-9kbnyqt3 121 19 , , , cord-325712-9kbnyqt3 121 20 Tanaka Tanaka NNP cord-325712-9kbnyqt3 121 21 and and CC cord-325712-9kbnyqt3 121 22 Sackmann Sackmann NNP cord-325712-9kbnyqt3 121 23 [ [ -LRB- cord-325712-9kbnyqt3 121 24 47 47 CD cord-325712-9kbnyqt3 121 25 ] ] -RRB- cord-325712-9kbnyqt3 121 26 , , , cord-325712-9kbnyqt3 121 27 and and CC cord-325712-9kbnyqt3 121 28 Castellana Castellana NNP cord-325712-9kbnyqt3 121 29 and and CC cord-325712-9kbnyqt3 121 30 Cremer Cremer NNP cord-325712-9kbnyqt3 121 31 [ [ -LRB- cord-325712-9kbnyqt3 121 32 48 48 CD cord-325712-9kbnyqt3 121 33 ] ] -RRB- cord-325712-9kbnyqt3 121 34 . . . cord-325712-9kbnyqt3 122 1 These these DT cord-325712-9kbnyqt3 122 2 supported support VBD cord-325712-9kbnyqt3 122 3 lipid lipid NN cord-325712-9kbnyqt3 122 4 bilayers bilayer NNS cord-325712-9kbnyqt3 122 5 act act VBP cord-325712-9kbnyqt3 122 6 as as IN cord-325712-9kbnyqt3 122 7 mimics mimic NNS cord-325712-9kbnyqt3 122 8 for for IN cord-325712-9kbnyqt3 122 9 cellular cellular JJ cord-325712-9kbnyqt3 122 10 membranes membrane NNS cord-325712-9kbnyqt3 122 11 and and CC cord-325712-9kbnyqt3 122 12 the the DT cord-325712-9kbnyqt3 122 13 compatibility compatibility NN cord-325712-9kbnyqt3 122 14 of of IN cord-325712-9kbnyqt3 122 15 these these DT cord-325712-9kbnyqt3 122 16 bilayers bilayer NNS cord-325712-9kbnyqt3 122 17 with with IN cord-325712-9kbnyqt3 122 18 flat flat JJ cord-325712-9kbnyqt3 122 19 glass glass NN cord-325712-9kbnyqt3 122 20 surfaces surface NNS cord-325712-9kbnyqt3 122 21 makes make VBZ cord-325712-9kbnyqt3 122 22 them -PRON- PRP cord-325712-9kbnyqt3 122 23 ideal ideal JJ cord-325712-9kbnyqt3 122 24 for for IN cord-325712-9kbnyqt3 122 25 coupling couple VBG cord-325712-9kbnyqt3 122 26 to to IN cord-325712-9kbnyqt3 122 27 microscopy microscopy NN cord-325712-9kbnyqt3 122 28 techniques technique NNS cord-325712-9kbnyqt3 122 29 . . . cord-325712-9kbnyqt3 123 1 Additionally additionally RB cord-325712-9kbnyqt3 123 2 , , , cord-325712-9kbnyqt3 123 3 supported support VBN cord-325712-9kbnyqt3 123 4 bilayers bilayer NNS cord-325712-9kbnyqt3 123 5 may may MD cord-325712-9kbnyqt3 123 6 be be VB cord-325712-9kbnyqt3 123 7 assembled assemble VBN cord-325712-9kbnyqt3 123 8 within within IN cord-325712-9kbnyqt3 123 9 a a DT cord-325712-9kbnyqt3 123 10 flow flow NN cord-325712-9kbnyqt3 123 11 cell cell NN cord-325712-9kbnyqt3 123 12 or or CC cord-325712-9kbnyqt3 123 13 microfluidic microfluidic JJ cord-325712-9kbnyqt3 123 14 device device NN cord-325712-9kbnyqt3 123 15 , , , cord-325712-9kbnyqt3 123 16 which which WDT cord-325712-9kbnyqt3 123 17 enables enable VBZ cord-325712-9kbnyqt3 123 18 the the DT cord-325712-9kbnyqt3 123 19 exchange exchange NN cord-325712-9kbnyqt3 123 20 of of IN cord-325712-9kbnyqt3 123 21 buffers buffer NNS cord-325712-9kbnyqt3 123 22 and and CC cord-325712-9kbnyqt3 123 23 , , , cord-325712-9kbnyqt3 123 24 consequently consequently RB cord-325712-9kbnyqt3 123 25 , , , cord-325712-9kbnyqt3 123 26 the the DT cord-325712-9kbnyqt3 123 27 precise precise JJ cord-325712-9kbnyqt3 123 28 control control NN cord-325712-9kbnyqt3 123 29 over over IN cord-325712-9kbnyqt3 123 30 the the DT cord-325712-9kbnyqt3 123 31 binding binding NN cord-325712-9kbnyqt3 123 32 and and CC cord-325712-9kbnyqt3 123 33 fusion fusion NN cord-325712-9kbnyqt3 123 34 environment environment NN cord-325712-9kbnyqt3 123 35 during during IN cord-325712-9kbnyqt3 123 36 single single JJ cord-325712-9kbnyqt3 123 37 virion virion NN cord-325712-9kbnyqt3 123 38 tracking tracking NN cord-325712-9kbnyqt3 123 39 microscopy microscopy NNS cord-325712-9kbnyqt3 123 40 . . . cord-325712-9kbnyqt3 124 1 The the DT cord-325712-9kbnyqt3 124 2 composition composition NN cord-325712-9kbnyqt3 124 3 of of IN cord-325712-9kbnyqt3 124 4 these these DT cord-325712-9kbnyqt3 124 5 bilayers bilayer NNS cord-325712-9kbnyqt3 124 6 is be VBZ cord-325712-9kbnyqt3 124 7 highly highly RB cord-325712-9kbnyqt3 124 8 tunable tunable JJ cord-325712-9kbnyqt3 124 9 , , , cord-325712-9kbnyqt3 124 10 ranging range VBG cord-325712-9kbnyqt3 124 11 from from IN cord-325712-9kbnyqt3 124 12 the the DT cord-325712-9kbnyqt3 124 13 simplest simple JJS cord-325712-9kbnyqt3 124 14 lipid lipid NN cord-325712-9kbnyqt3 124 15 components component NNS cord-325712-9kbnyqt3 124 16 , , , cord-325712-9kbnyqt3 124 17 to to IN cord-325712-9kbnyqt3 124 18 recapitulating recapitulate VBG cord-325712-9kbnyqt3 124 19 the the DT cord-325712-9kbnyqt3 124 20 complexity complexity NN cord-325712-9kbnyqt3 124 21 of of IN cord-325712-9kbnyqt3 124 22 the the DT cord-325712-9kbnyqt3 124 23 plasma plasma NN cord-325712-9kbnyqt3 124 24 cell cell NN cord-325712-9kbnyqt3 124 25 membrane membrane NN cord-325712-9kbnyqt3 124 26 of of IN cord-325712-9kbnyqt3 124 27 specific specific JJ cord-325712-9kbnyqt3 124 28 cell cell NN cord-325712-9kbnyqt3 124 29 types type NNS cord-325712-9kbnyqt3 124 30 ( ( -LRB- cord-325712-9kbnyqt3 124 31 Fig Fig NNP cord-325712-9kbnyqt3 124 32 . . . cord-325712-9kbnyqt3 124 33 2.4 2.4 CD cord-325712-9kbnyqt3 124 34 ) ) -RRB- cord-325712-9kbnyqt3 124 35 . . . cord-325712-9kbnyqt3 125 1 Initial initial JJ cord-325712-9kbnyqt3 125 2 studies study NNS cord-325712-9kbnyqt3 125 3 employed employ VBD cord-325712-9kbnyqt3 125 4 purely purely RB cord-325712-9kbnyqt3 125 5 lipid lipid JJ cord-325712-9kbnyqt3 125 6 bilayers bilayer NNS cord-325712-9kbnyqt3 125 7 with with IN cord-325712-9kbnyqt3 125 8 glycolipid glycolipid NNP cord-325712-9kbnyqt3 125 9 viral viral JJ cord-325712-9kbnyqt3 125 10 receptors receptor NNS cord-325712-9kbnyqt3 125 11 [ [ -LRB- cord-325712-9kbnyqt3 125 12 12 12 CD cord-325712-9kbnyqt3 125 13 , , , cord-325712-9kbnyqt3 125 14 33 33 CD cord-325712-9kbnyqt3 125 15 , , , cord-325712-9kbnyqt3 125 16 34 34 CD cord-325712-9kbnyqt3 125 17 , , , cord-325712-9kbnyqt3 125 18 49 49 CD cord-325712-9kbnyqt3 125 19 ] ] -RRB- cord-325712-9kbnyqt3 125 20 . . . cord-325712-9kbnyqt3 126 1 More More JJR cord-325712-9kbnyqt3 126 2 recent recent JJ cord-325712-9kbnyqt3 126 3 work work NN cord-325712-9kbnyqt3 126 4 has have VBZ cord-325712-9kbnyqt3 126 5 used use VBN cord-325712-9kbnyqt3 126 6 reconstituted reconstitute VBN cord-325712-9kbnyqt3 126 7 proteoliposomes proteoliposome NNS cord-325712-9kbnyqt3 126 8 that that WDT cord-325712-9kbnyqt3 126 9 contain contain VBP cord-325712-9kbnyqt3 126 10 protein protein NN cord-325712-9kbnyqt3 126 11 receptors receptor NNS cord-325712-9kbnyqt3 126 12 [ [ -LRB- cord-325712-9kbnyqt3 126 13 50 50 CD cord-325712-9kbnyqt3 126 14 ] ] -RRB- cord-325712-9kbnyqt3 126 15 . . . cord-325712-9kbnyqt3 127 1 There there EX cord-325712-9kbnyqt3 127 2 has have VBZ cord-325712-9kbnyqt3 127 3 also also RB cord-325712-9kbnyqt3 127 4 been be VBN cord-325712-9kbnyqt3 127 5 progress progress NN cord-325712-9kbnyqt3 127 6 in in IN cord-325712-9kbnyqt3 127 7 using use VBG cord-325712-9kbnyqt3 127 8 composite composite JJ cord-325712-9kbnyqt3 127 9 membranes membrane NNS cord-325712-9kbnyqt3 127 10 made make VBN cord-325712-9kbnyqt3 127 11 from from IN cord-325712-9kbnyqt3 127 12 cell cell NN cord-325712-9kbnyqt3 127 13 - - HYPH cord-325712-9kbnyqt3 127 14 derived derive VBN cord-325712-9kbnyqt3 127 15 membrane membrane NN cord-325712-9kbnyqt3 127 16 components component NNS cord-325712-9kbnyqt3 127 17 mixed mix VBN cord-325712-9kbnyqt3 127 18 with with IN cord-325712-9kbnyqt3 127 19 PEGylated pegylated JJ cord-325712-9kbnyqt3 127 20 liposomes liposome NNS cord-325712-9kbnyqt3 127 21 to to TO cord-325712-9kbnyqt3 127 22 engender engender VB cord-325712-9kbnyqt3 127 23 the the DT cord-325712-9kbnyqt3 127 24 SLB SLB NNP cord-325712-9kbnyqt3 127 25 with with IN cord-325712-9kbnyqt3 127 26 both both DT cord-325712-9kbnyqt3 127 27 biologically biologically RB cord-325712-9kbnyqt3 127 28 relevant relevant JJ cord-325712-9kbnyqt3 127 29 material material NN cord-325712-9kbnyqt3 127 30 ( ( -LRB- cord-325712-9kbnyqt3 127 31 receptors receptor NNS cord-325712-9kbnyqt3 127 32 , , , cord-325712-9kbnyqt3 127 33 etc etc FW cord-325712-9kbnyqt3 127 34 . . . cord-325712-9kbnyqt3 127 35 ) ) -RRB- cord-325712-9kbnyqt3 127 36 and and CC cord-325712-9kbnyqt3 127 37 a a DT cord-325712-9kbnyqt3 127 38 built build VBN cord-325712-9kbnyqt3 127 39 - - HYPH cord-325712-9kbnyqt3 127 40 in in RP cord-325712-9kbnyqt3 127 41 cushion cushion NN cord-325712-9kbnyqt3 127 42 to to TO cord-325712-9kbnyqt3 127 43 maintain maintain VB cord-325712-9kbnyqt3 127 44 constituent constituent JJ cord-325712-9kbnyqt3 127 45 mobility mobility NN cord-325712-9kbnyqt3 127 46 [ [ -LRB- cord-325712-9kbnyqt3 127 47 51 51 CD cord-325712-9kbnyqt3 127 48 , , , cord-325712-9kbnyqt3 127 49 52 52 CD cord-325712-9kbnyqt3 127 50 ] ] -RRB- cord-325712-9kbnyqt3 127 51 . . . cord-325712-9kbnyqt3 128 1 Other other JJ cord-325712-9kbnyqt3 128 2 work work NN cord-325712-9kbnyqt3 128 3 has have VBZ cord-325712-9kbnyqt3 128 4 demonstrated demonstrate VBN cord-325712-9kbnyqt3 128 5 the the DT cord-325712-9kbnyqt3 128 6 ability ability NN cord-325712-9kbnyqt3 128 7 to to TO cord-325712-9kbnyqt3 128 8 form form VB cord-325712-9kbnyqt3 128 9 bilayers bilayer NNS cord-325712-9kbnyqt3 128 10 from from IN cord-325712-9kbnyqt3 128 11 cell cell NN cord-325712-9kbnyqt3 128 12 plasma plasma NN cord-325712-9kbnyqt3 128 13 membrane membrane NN cord-325712-9kbnyqt3 128 14 blebs bleb NNS cord-325712-9kbnyqt3 128 15 as as IN cord-325712-9kbnyqt3 128 16 a a DT cord-325712-9kbnyqt3 128 17 way way NN cord-325712-9kbnyqt3 128 18 to to TO cord-325712-9kbnyqt3 128 19 incorporate incorporate VB cord-325712-9kbnyqt3 128 20 transmembrane transmembrane JJ cord-325712-9kbnyqt3 128 21 proteinaceous proteinaceous JJ cord-325712-9kbnyqt3 128 22 receptors receptor NNS cord-325712-9kbnyqt3 128 23 and and CC cord-325712-9kbnyqt3 128 24 complete complete VB cord-325712-9kbnyqt3 128 25 native native JJ cord-325712-9kbnyqt3 128 26 cell cell NN cord-325712-9kbnyqt3 128 27 materials material NNS cord-325712-9kbnyqt3 128 28 into into IN cord-325712-9kbnyqt3 128 29 planar planar JJ cord-325712-9kbnyqt3 128 30 geometries geometry NNS cord-325712-9kbnyqt3 128 31 [ [ -LRB- cord-325712-9kbnyqt3 128 32 13 13 CD cord-325712-9kbnyqt3 128 33 , , , cord-325712-9kbnyqt3 128 34 53 53 CD cord-325712-9kbnyqt3 128 35 , , , cord-325712-9kbnyqt3 128 36 54 54 CD cord-325712-9kbnyqt3 128 37 ] ] -RRB- cord-325712-9kbnyqt3 128 38 . . . cord-325712-9kbnyqt3 129 1 The the DT cord-325712-9kbnyqt3 129 2 incorporation incorporation NN cord-325712-9kbnyqt3 129 3 of of IN cord-325712-9kbnyqt3 129 4 transmembrane transmembrane NN cord-325712-9kbnyqt3 129 5 proteins protein NNS cord-325712-9kbnyqt3 129 6 greatly greatly RB cord-325712-9kbnyqt3 129 7 expands expand VBZ cord-325712-9kbnyqt3 129 8 the the DT cord-325712-9kbnyqt3 129 9 range range NN cord-325712-9kbnyqt3 129 10 of of IN cord-325712-9kbnyqt3 129 11 viruses virus NNS cord-325712-9kbnyqt3 129 12 that that WDT cord-325712-9kbnyqt3 129 13 can can MD cord-325712-9kbnyqt3 129 14 be be VB cord-325712-9kbnyqt3 129 15 studied study VBN cord-325712-9kbnyqt3 129 16 with with IN cord-325712-9kbnyqt3 129 17 single single JJ cord-325712-9kbnyqt3 129 18 virions virion NNS cord-325712-9kbnyqt3 129 19 tracking tracking NN cord-325712-9kbnyqt3 129 20 techniques technique NNS cord-325712-9kbnyqt3 129 21 [ [ -LRB- cord-325712-9kbnyqt3 129 22 13 13 CD cord-325712-9kbnyqt3 129 23 ] ] -RRB- cord-325712-9kbnyqt3 129 24 . . . cord-325712-9kbnyqt3 130 1 Notably notably RB cord-325712-9kbnyqt3 130 2 , , , cord-325712-9kbnyqt3 130 3 the the DT cord-325712-9kbnyqt3 130 4 simplest simple JJS cord-325712-9kbnyqt3 130 5 lipid lipid NN cord-325712-9kbnyqt3 130 6 - - HYPH cord-325712-9kbnyqt3 130 7 only only RB cord-325712-9kbnyqt3 130 8 bilayer bilayer NN cord-325712-9kbnyqt3 130 9 on on IN cord-325712-9kbnyqt3 130 10 glass glass NN cord-325712-9kbnyqt3 130 11 is be VBZ cord-325712-9kbnyqt3 130 12 roughly roughly RB cord-325712-9kbnyqt3 130 13 4 4 CD cord-325712-9kbnyqt3 130 14 nm nm NN cord-325712-9kbnyqt3 130 15 thick thick JJ cord-325712-9kbnyqt3 130 16 and and CC cord-325712-9kbnyqt3 130 17 sits sit VBZ cord-325712-9kbnyqt3 130 18 above above IN cord-325712-9kbnyqt3 130 19 a a DT cord-325712-9kbnyqt3 130 20 thin thin JJ cord-325712-9kbnyqt3 130 21 layer layer NN cord-325712-9kbnyqt3 130 22 of of IN cord-325712-9kbnyqt3 130 23 water water NN cord-325712-9kbnyqt3 130 24 on on IN cord-325712-9kbnyqt3 130 25 the the DT cord-325712-9kbnyqt3 130 26 order order NN cord-325712-9kbnyqt3 130 27 of of IN cord-325712-9kbnyqt3 130 28 a a DT cord-325712-9kbnyqt3 130 29 nanometer nanometer NN cord-325712-9kbnyqt3 130 30 thick thick JJ cord-325712-9kbnyqt3 130 31 [ [ -LRB- cord-325712-9kbnyqt3 130 32 55 55 CD cord-325712-9kbnyqt3 130 33 , , , cord-325712-9kbnyqt3 130 34 56 56 CD cord-325712-9kbnyqt3 130 35 ] ] -RRB- cord-325712-9kbnyqt3 130 36 . . . cord-325712-9kbnyqt3 131 1 This this DT cord-325712-9kbnyqt3 131 2 feature feature NN cord-325712-9kbnyqt3 131 3 enables enable VBZ cord-325712-9kbnyqt3 131 4 the the DT cord-325712-9kbnyqt3 131 5 two two CD cord-325712-9kbnyqt3 131 6 - - HYPH cord-325712-9kbnyqt3 131 7 dimensional dimensional JJ cord-325712-9kbnyqt3 131 8 mobility mobility NN cord-325712-9kbnyqt3 131 9 of of IN cord-325712-9kbnyqt3 131 10 lipids lipid NNS cord-325712-9kbnyqt3 131 11 within within IN cord-325712-9kbnyqt3 131 12 the the DT cord-325712-9kbnyqt3 131 13 bilayer bilayer NN cord-325712-9kbnyqt3 131 14 necessary necessary JJ cord-325712-9kbnyqt3 131 15 for for IN cord-325712-9kbnyqt3 131 16 membrane membrane NN cord-325712-9kbnyqt3 131 17 fusion fusion NN cord-325712-9kbnyqt3 131 18 , , , cord-325712-9kbnyqt3 131 19 but but CC cord-325712-9kbnyqt3 131 20 mobility mobility NN cord-325712-9kbnyqt3 131 21 is be VBZ cord-325712-9kbnyqt3 131 22 also also RB cord-325712-9kbnyqt3 131 23 a a DT cord-325712-9kbnyqt3 131 24 key key JJ cord-325712-9kbnyqt3 131 25 property property NN cord-325712-9kbnyqt3 131 26 for for IN cord-325712-9kbnyqt3 131 27 allowing allow VBG cord-325712-9kbnyqt3 131 28 receptors receptor NNS cord-325712-9kbnyqt3 131 29 to to TO cord-325712-9kbnyqt3 131 30 rearrange rearrange VB cord-325712-9kbnyqt3 131 31 to to TO cord-325712-9kbnyqt3 131 32 permit permit VB cord-325712-9kbnyqt3 131 33 multivalent multivalent JJ cord-325712-9kbnyqt3 131 34 binding bind VBG cord-325712-9kbnyqt3 131 35 interactions interaction NNS cord-325712-9kbnyqt3 131 36 , , , cord-325712-9kbnyqt3 131 37 as as IN cord-325712-9kbnyqt3 131 38 they -PRON- PRP cord-325712-9kbnyqt3 131 39 do do VBP cord-325712-9kbnyqt3 131 40 in in IN cord-325712-9kbnyqt3 131 41 live live JJ cord-325712-9kbnyqt3 131 42 cell cell NN cord-325712-9kbnyqt3 131 43 membranes membrane NNS cord-325712-9kbnyqt3 131 44 . . . cord-325712-9kbnyqt3 132 1 Mobility mobility NN cord-325712-9kbnyqt3 132 2 of of IN cord-325712-9kbnyqt3 132 3 protein protein NN cord-325712-9kbnyqt3 132 4 receptors receptor NNS cord-325712-9kbnyqt3 132 5 , , , cord-325712-9kbnyqt3 132 6 particularly particularly RB cord-325712-9kbnyqt3 132 7 those those DT cord-325712-9kbnyqt3 132 8 with with IN cord-325712-9kbnyqt3 132 9 transmembrane transmembrane NN cord-325712-9kbnyqt3 132 10 domains domain NNS cord-325712-9kbnyqt3 132 11 , , , cord-325712-9kbnyqt3 132 12 can can MD cord-325712-9kbnyqt3 132 13 be be VB cord-325712-9kbnyqt3 132 14 a a DT cord-325712-9kbnyqt3 132 15 challenge challenge NN cord-325712-9kbnyqt3 132 16 in in IN cord-325712-9kbnyqt3 132 17 these these DT cord-325712-9kbnyqt3 132 18 platforms platform NNS cord-325712-9kbnyqt3 132 19 if if IN cord-325712-9kbnyqt3 132 20 the the DT cord-325712-9kbnyqt3 132 21 water water NN cord-325712-9kbnyqt3 132 22 gap gap NN cord-325712-9kbnyqt3 132 23 is be VBZ cord-325712-9kbnyqt3 132 24 insufficient insufficient JJ cord-325712-9kbnyqt3 132 25 for for IN cord-325712-9kbnyqt3 132 26 limiting limit VBG cord-325712-9kbnyqt3 132 27 interaction interaction NN cord-325712-9kbnyqt3 132 28 between between IN cord-325712-9kbnyqt3 132 29 the the DT cord-325712-9kbnyqt3 132 30 protein protein NN cord-325712-9kbnyqt3 132 31 and and CC cord-325712-9kbnyqt3 132 32 the the DT cord-325712-9kbnyqt3 132 33 glass glass NN cord-325712-9kbnyqt3 132 34 support support NN cord-325712-9kbnyqt3 132 35 . . . cord-325712-9kbnyqt3 133 1 To to TO cord-325712-9kbnyqt3 133 2 overcome overcome VB cord-325712-9kbnyqt3 133 3 this this DT cord-325712-9kbnyqt3 133 4 challenge challenge NN cord-325712-9kbnyqt3 133 5 , , , cord-325712-9kbnyqt3 133 6 various various JJ cord-325712-9kbnyqt3 133 7 cushions cushion NNS cord-325712-9kbnyqt3 133 8 , , , cord-325712-9kbnyqt3 133 9 such such JJ cord-325712-9kbnyqt3 133 10 as as IN cord-325712-9kbnyqt3 133 11 polyethylene polyethylene NN cord-325712-9kbnyqt3 133 12 glycol glycol NN cord-325712-9kbnyqt3 133 13 ( ( -LRB- cord-325712-9kbnyqt3 133 14 PEG PEG NNP cord-325712-9kbnyqt3 133 15 ) ) -RRB- cord-325712-9kbnyqt3 133 16 [ [ -LRB- cord-325712-9kbnyqt3 133 17 52 52 CD cord-325712-9kbnyqt3 133 18 ] ] -RRB- cord-325712-9kbnyqt3 133 19 , , , cord-325712-9kbnyqt3 133 20 bovine bovine JJ cord-325712-9kbnyqt3 133 21 serum serum NN cord-325712-9kbnyqt3 133 22 albumin albumin NN cord-325712-9kbnyqt3 133 23 , , , cord-325712-9kbnyqt3 133 24 dextran dextran NN cord-325712-9kbnyqt3 133 25 [ [ -LRB- cord-325712-9kbnyqt3 133 26 33 33 CD cord-325712-9kbnyqt3 133 27 , , , cord-325712-9kbnyqt3 133 28 57 57 CD cord-325712-9kbnyqt3 133 29 ] ] -RRB- cord-325712-9kbnyqt3 133 30 , , , cord-325712-9kbnyqt3 133 31 or or CC cord-325712-9kbnyqt3 133 32 polyelectrolyte polyelectrolyte NN cord-325712-9kbnyqt3 133 33 brushes brush NNS cord-325712-9kbnyqt3 133 34 [ [ -LRB- cord-325712-9kbnyqt3 133 35 54 54 CD cord-325712-9kbnyqt3 133 36 ] ] -RRB- cord-325712-9kbnyqt3 133 37 , , , cord-325712-9kbnyqt3 133 38 have have VBP cord-325712-9kbnyqt3 133 39 been be VBN cord-325712-9kbnyqt3 133 40 placed place VBN cord-325712-9kbnyqt3 133 41 between between IN cord-325712-9kbnyqt3 133 42 the the DT cord-325712-9kbnyqt3 133 43 bilayer bilayer NN cord-325712-9kbnyqt3 133 44 and and CC cord-325712-9kbnyqt3 133 45 the the DT cord-325712-9kbnyqt3 133 46 supporting support VBG cord-325712-9kbnyqt3 133 47 surface surface NN cord-325712-9kbnyqt3 133 48 to to TO cord-325712-9kbnyqt3 133 49 improve improve VB cord-325712-9kbnyqt3 133 50 protein protein NN cord-325712-9kbnyqt3 133 51 mobility mobility NN cord-325712-9kbnyqt3 133 52 [ [ -LRB- cord-325712-9kbnyqt3 133 53 58 58 CD cord-325712-9kbnyqt3 133 54 ] ] -RRB- cord-325712-9kbnyqt3 133 55 . . . cord-325712-9kbnyqt3 134 1 It -PRON- PRP cord-325712-9kbnyqt3 134 2 is be VBZ cord-325712-9kbnyqt3 134 3 also also RB cord-325712-9kbnyqt3 134 4 possible possible JJ cord-325712-9kbnyqt3 134 5 to to TO cord-325712-9kbnyqt3 134 6 form form VB cord-325712-9kbnyqt3 134 7 supported support VBN cord-325712-9kbnyqt3 134 8 lipid lipid NN cord-325712-9kbnyqt3 134 9 bilayers bilayer NNS cord-325712-9kbnyqt3 134 10 that that WDT cord-325712-9kbnyqt3 134 11 mimic mimic VBP cord-325712-9kbnyqt3 134 12 the the DT cord-325712-9kbnyqt3 134 13 viral viral JJ cord-325712-9kbnyqt3 134 14 membrane membrane NN cord-325712-9kbnyqt3 134 15 instead instead RB cord-325712-9kbnyqt3 134 16 of of IN cord-325712-9kbnyqt3 134 17 the the DT cord-325712-9kbnyqt3 134 18 host host NN cord-325712-9kbnyqt3 134 19 membrane membrane NN cord-325712-9kbnyqt3 134 20 and and CC cord-325712-9kbnyqt3 134 21 conduct conduct VB cord-325712-9kbnyqt3 134 22 experiments experiment NNS cord-325712-9kbnyqt3 134 23 in in IN cord-325712-9kbnyqt3 134 24 the the DT cord-325712-9kbnyqt3 134 25 opposite opposite JJ cord-325712-9kbnyqt3 134 26 configuration configuration NN cord-325712-9kbnyqt3 134 27 . . . cord-325712-9kbnyqt3 135 1 Here here RB cord-325712-9kbnyqt3 135 2 , , , cord-325712-9kbnyqt3 135 3 binding binding NN cord-325712-9kbnyqt3 135 4 and and CC cord-325712-9kbnyqt3 135 5 fusion fusion NN cord-325712-9kbnyqt3 135 6 is be VBZ cord-325712-9kbnyqt3 135 7 studied study VBN cord-325712-9kbnyqt3 135 8 by by IN cord-325712-9kbnyqt3 135 9 monitoring monitor VBG cord-325712-9kbnyqt3 135 10 liposomes liposome NNS cord-325712-9kbnyqt3 135 11 decorated decorate VBN cord-325712-9kbnyqt3 135 12 with with IN cord-325712-9kbnyqt3 135 13 host host NN cord-325712-9kbnyqt3 135 14 cell cell NN cord-325712-9kbnyqt3 135 15 receptors receptor NNS cord-325712-9kbnyqt3 135 16 interacting interact VBG cord-325712-9kbnyqt3 135 17 with with IN cord-325712-9kbnyqt3 135 18 the the DT cord-325712-9kbnyqt3 135 19 planar planar JJ cord-325712-9kbnyqt3 135 20 virus virus NN cord-325712-9kbnyqt3 135 21 - - HYPH cord-325712-9kbnyqt3 135 22 like like JJ cord-325712-9kbnyqt3 135 23 bilayer bilayer NN cord-325712-9kbnyqt3 135 24 containing contain VBG cord-325712-9kbnyqt3 135 25 embedded embed VBN cord-325712-9kbnyqt3 135 26 viral viral JJ cord-325712-9kbnyqt3 135 27 proteins protein NNS cord-325712-9kbnyqt3 135 28 [ [ -LRB- cord-325712-9kbnyqt3 135 29 59 59 CD cord-325712-9kbnyqt3 135 30 ] ] -RRB- cord-325712-9kbnyqt3 135 31 [ [ -LRB- cord-325712-9kbnyqt3 135 32 60 60 CD cord-325712-9kbnyqt3 135 33 ] ] -RRB- cord-325712-9kbnyqt3 135 34 [ [ -LRB- cord-325712-9kbnyqt3 135 35 61 61 CD cord-325712-9kbnyqt3 135 36 ] ] -RRB- cord-325712-9kbnyqt3 135 37 . . . cord-325712-9kbnyqt3 136 1 Such such PDT cord-325712-9kbnyqt3 136 2 an an DT cord-325712-9kbnyqt3 136 3 arrangement arrangement NN cord-325712-9kbnyqt3 136 4 could could MD cord-325712-9kbnyqt3 136 5 be be VB cord-325712-9kbnyqt3 136 6 used use VBN cord-325712-9kbnyqt3 136 7 for for IN cord-325712-9kbnyqt3 136 8 screening screening NN cord-325712-9kbnyqt3 136 9 applications application NNS cord-325712-9kbnyqt3 136 10 of of IN cord-325712-9kbnyqt3 136 11 antivirals antiviral NNS cord-325712-9kbnyqt3 136 12 that that WDT cord-325712-9kbnyqt3 136 13 target target VBP cord-325712-9kbnyqt3 136 14 entry entry NN cord-325712-9kbnyqt3 136 15 processes process NNS cord-325712-9kbnyqt3 136 16 , , , cord-325712-9kbnyqt3 136 17 without without IN cord-325712-9kbnyqt3 136 18 the the DT cord-325712-9kbnyqt3 136 19 need need NN cord-325712-9kbnyqt3 136 20 for for IN cord-325712-9kbnyqt3 136 21 live live JJ cord-325712-9kbnyqt3 136 22 virus virus NN cord-325712-9kbnyqt3 136 23 or or CC cord-325712-9kbnyqt3 136 24 pseudotyped pseudotyped NN cord-325712-9kbnyqt3 136 25 particles particle NNS cord-325712-9kbnyqt3 136 26 . . . cord-325712-9kbnyqt3 137 1 In in IN cord-325712-9kbnyqt3 137 2 summary summary NN cord-325712-9kbnyqt3 137 3 , , , cord-325712-9kbnyqt3 137 4 biomimetic biomimetic JJ cord-325712-9kbnyqt3 137 5 platforms platform NNS cord-325712-9kbnyqt3 137 6 enable enable VBP cord-325712-9kbnyqt3 137 7 a a DT cord-325712-9kbnyqt3 137 8 level level NN cord-325712-9kbnyqt3 137 9 of of IN cord-325712-9kbnyqt3 137 10 environmental environmental JJ cord-325712-9kbnyqt3 137 11 control control NN cord-325712-9kbnyqt3 137 12 that that WDT cord-325712-9kbnyqt3 137 13 can can MD cord-325712-9kbnyqt3 137 14 not not RB cord-325712-9kbnyqt3 137 15 be be VB cord-325712-9kbnyqt3 137 16 attained attain VBN cord-325712-9kbnyqt3 137 17 in in IN cord-325712-9kbnyqt3 137 18 live live JJ cord-325712-9kbnyqt3 137 19 cell cell NN cord-325712-9kbnyqt3 137 20 particle particle NN cord-325712-9kbnyqt3 137 21 tracking tracking NN cord-325712-9kbnyqt3 137 22 techniques technique NNS cord-325712-9kbnyqt3 137 23 . . . cord-325712-9kbnyqt3 138 1 First first RB cord-325712-9kbnyqt3 138 2 , , , cord-325712-9kbnyqt3 138 3 there there EX cord-325712-9kbnyqt3 138 4 is be VBZ cord-325712-9kbnyqt3 138 5 a a DT cord-325712-9kbnyqt3 138 6 degree degree NN cord-325712-9kbnyqt3 138 7 of of IN cord-325712-9kbnyqt3 138 8 control control NN cord-325712-9kbnyqt3 138 9 over over IN cord-325712-9kbnyqt3 138 10 the the DT cord-325712-9kbnyqt3 138 11 host host NN cord-325712-9kbnyqt3 138 12 cell cell NN cord-325712-9kbnyqt3 138 13 membrane membrane NN cord-325712-9kbnyqt3 138 14 mimic mimic VBP cord-325712-9kbnyqt3 138 15 's 's POS cord-325712-9kbnyqt3 138 16 composition composition NN cord-325712-9kbnyqt3 138 17 that that WDT cord-325712-9kbnyqt3 138 18 is be VBZ cord-325712-9kbnyqt3 138 19 difficult difficult JJ cord-325712-9kbnyqt3 138 20 to to TO cord-325712-9kbnyqt3 138 21 alter alter VB cord-325712-9kbnyqt3 138 22 in in IN cord-325712-9kbnyqt3 138 23 live live JJ cord-325712-9kbnyqt3 138 24 cells cell NNS cord-325712-9kbnyqt3 138 25 . . . cord-325712-9kbnyqt3 139 1 Second second RB cord-325712-9kbnyqt3 139 2 , , , cord-325712-9kbnyqt3 139 3 in in IN cord-325712-9kbnyqt3 139 4 these these DT cord-325712-9kbnyqt3 139 5 platforms platform NNS cord-325712-9kbnyqt3 139 6 , , , cord-325712-9kbnyqt3 139 7 the the DT cord-325712-9kbnyqt3 139 8 buffers buffer NNS cord-325712-9kbnyqt3 139 9 in in IN cord-325712-9kbnyqt3 139 10 contact contact NN cord-325712-9kbnyqt3 139 11 with with IN cord-325712-9kbnyqt3 139 12 the the DT cord-325712-9kbnyqt3 139 13 virus virus NN cord-325712-9kbnyqt3 139 14 can can MD cord-325712-9kbnyqt3 139 15 have have VB cord-325712-9kbnyqt3 139 16 a a DT cord-325712-9kbnyqt3 139 17 defined define VBN cord-325712-9kbnyqt3 139 18 composition composition NN cord-325712-9kbnyqt3 139 19 and and CC cord-325712-9kbnyqt3 139 20 the the DT cord-325712-9kbnyqt3 139 21 experimenter experimenter NN cord-325712-9kbnyqt3 139 22 controls control VBZ cord-325712-9kbnyqt3 139 23 the the DT cord-325712-9kbnyqt3 139 24 timing timing NN cord-325712-9kbnyqt3 139 25 and and CC cord-325712-9kbnyqt3 139 26 order order NN cord-325712-9kbnyqt3 139 27 of of IN cord-325712-9kbnyqt3 139 28 exposure exposure NN cord-325712-9kbnyqt3 139 29 to to IN cord-325712-9kbnyqt3 139 30 proteases protease NNS cord-325712-9kbnyqt3 139 31 , , , cord-325712-9kbnyqt3 139 32 pH pH NNP cord-325712-9kbnyqt3 139 33 , , , cord-325712-9kbnyqt3 139 34 or or CC cord-325712-9kbnyqt3 139 35 any any DT cord-325712-9kbnyqt3 139 36 other other JJ cord-325712-9kbnyqt3 139 37 component component NN cord-325712-9kbnyqt3 139 38 of of IN cord-325712-9kbnyqt3 139 39 interest interest NN cord-325712-9kbnyqt3 139 40 to to IN cord-325712-9kbnyqt3 139 41 the the DT cord-325712-9kbnyqt3 139 42 virus virus NN cord-325712-9kbnyqt3 139 43 . . . cord-325712-9kbnyqt3 140 1 But but CC cord-325712-9kbnyqt3 140 2 perhaps perhaps RB cord-325712-9kbnyqt3 140 3 the the DT cord-325712-9kbnyqt3 140 4 most most RBS cord-325712-9kbnyqt3 140 5 salient salient JJ cord-325712-9kbnyqt3 140 6 feature feature NN cord-325712-9kbnyqt3 140 7 of of IN cord-325712-9kbnyqt3 140 8 this this DT cord-325712-9kbnyqt3 140 9 experimental experimental JJ cord-325712-9kbnyqt3 140 10 approach approach NN cord-325712-9kbnyqt3 140 11 is be VBZ cord-325712-9kbnyqt3 140 12 that that IN cord-325712-9kbnyqt3 140 13 these these DT cord-325712-9kbnyqt3 140 14 platforms platform NNS cord-325712-9kbnyqt3 140 15 allow allow VBP cord-325712-9kbnyqt3 140 16 detailed detailed JJ cord-325712-9kbnyqt3 140 17 examination examination NN cord-325712-9kbnyqt3 140 18 of of IN cord-325712-9kbnyqt3 140 19 the the DT cord-325712-9kbnyqt3 140 20 binding binding NN cord-325712-9kbnyqt3 140 21 and and CC cord-325712-9kbnyqt3 140 22 membrane membrane NN cord-325712-9kbnyqt3 140 23 fusion fusion NN cord-325712-9kbnyqt3 140 24 process process NN cord-325712-9kbnyqt3 140 25 and and CC cord-325712-9kbnyqt3 140 26 gathering gathering NN cord-325712-9kbnyqt3 140 27 of of IN cord-325712-9kbnyqt3 140 28 dynamic dynamic JJ cord-325712-9kbnyqt3 140 29 data datum NNS cord-325712-9kbnyqt3 140 30 from from IN cord-325712-9kbnyqt3 140 31 these these DT cord-325712-9kbnyqt3 140 32 processes process NNS cord-325712-9kbnyqt3 140 33 . . . cord-325712-9kbnyqt3 141 1 However however RB cord-325712-9kbnyqt3 141 2 , , , cord-325712-9kbnyqt3 141 3 the the DT cord-325712-9kbnyqt3 141 4 two two CD cord-325712-9kbnyqt3 141 5 - - HYPH cord-325712-9kbnyqt3 141 6 dimensional dimensional JJ cord-325712-9kbnyqt3 141 7 , , , cord-325712-9kbnyqt3 141 8 in in IN cord-325712-9kbnyqt3 141 9 vitro vitro FW cord-325712-9kbnyqt3 141 10 nature nature NN cord-325712-9kbnyqt3 141 11 of of IN cord-325712-9kbnyqt3 141 12 these these DT cord-325712-9kbnyqt3 141 13 platforms platform NNS cord-325712-9kbnyqt3 141 14 make make VBP cord-325712-9kbnyqt3 141 15 them -PRON- PRP cord-325712-9kbnyqt3 141 16 unsuitable unsuitable JJ cord-325712-9kbnyqt3 141 17 for for IN cord-325712-9kbnyqt3 141 18 measuring measure VBG cord-325712-9kbnyqt3 141 19 cytoskeletal cytoskeletal JJ cord-325712-9kbnyqt3 141 20 involvement involvement NN cord-325712-9kbnyqt3 141 21 in in IN cord-325712-9kbnyqt3 141 22 entry entry NN cord-325712-9kbnyqt3 141 23 . . . cord-325712-9kbnyqt3 142 1 Thus thus RB cord-325712-9kbnyqt3 142 2 , , , cord-325712-9kbnyqt3 142 3 to to TO cord-325712-9kbnyqt3 142 4 obtain obtain VB cord-325712-9kbnyqt3 142 5 the the DT cord-325712-9kbnyqt3 142 6 most most RBS cord-325712-9kbnyqt3 142 7 complete complete JJ cord-325712-9kbnyqt3 142 8 information information NN cord-325712-9kbnyqt3 142 9 about about IN cord-325712-9kbnyqt3 142 10 the the DT cord-325712-9kbnyqt3 142 11 infection infection NN cord-325712-9kbnyqt3 142 12 process process NN cord-325712-9kbnyqt3 142 13 , , , cord-325712-9kbnyqt3 142 14 combining combine VBG cord-325712-9kbnyqt3 142 15 data datum NNS cord-325712-9kbnyqt3 142 16 from from IN cord-325712-9kbnyqt3 142 17 complementary complementary JJ cord-325712-9kbnyqt3 142 18 approaches approach NNS cord-325712-9kbnyqt3 142 19 using use VBG cord-325712-9kbnyqt3 142 20 live live JJ cord-325712-9kbnyqt3 142 21 cells cell NNS cord-325712-9kbnyqt3 142 22 and and CC cord-325712-9kbnyqt3 142 23 biomimetic biomimetic JJ cord-325712-9kbnyqt3 142 24 platforms platform NNS cord-325712-9kbnyqt3 142 25 is be VBZ cord-325712-9kbnyqt3 142 26 an an DT cord-325712-9kbnyqt3 142 27 excellent excellent JJ cord-325712-9kbnyqt3 142 28 strategy strategy NN cord-325712-9kbnyqt3 142 29 . . . cord-325712-9kbnyqt3 143 1 In in IN cord-325712-9kbnyqt3 143 2 the the DT cord-325712-9kbnyqt3 143 3 following following JJ cord-325712-9kbnyqt3 143 4 sections section NNS cord-325712-9kbnyqt3 143 5 we -PRON- PRP cord-325712-9kbnyqt3 143 6 describe describe VBP cord-325712-9kbnyqt3 143 7 how how WRB cord-325712-9kbnyqt3 143 8 single single JJ cord-325712-9kbnyqt3 143 9 virion virion NN cord-325712-9kbnyqt3 143 10 tracking tracking NN cord-325712-9kbnyqt3 143 11 has have VBZ cord-325712-9kbnyqt3 143 12 been be VBN cord-325712-9kbnyqt3 143 13 applied apply VBN cord-325712-9kbnyqt3 143 14 to to TO cord-325712-9kbnyqt3 143 15 investigate investigate VB cord-325712-9kbnyqt3 143 16 different different JJ cord-325712-9kbnyqt3 143 17 steps step NNS cord-325712-9kbnyqt3 143 18 in in IN cord-325712-9kbnyqt3 143 19 virus virus NN cord-325712-9kbnyqt3 143 20 entry entry NN cord-325712-9kbnyqt3 143 21 . . . cord-325712-9kbnyqt3 144 1 We -PRON- PRP cord-325712-9kbnyqt3 144 2 also also RB cord-325712-9kbnyqt3 144 3 include include VBP cord-325712-9kbnyqt3 144 4 overviews overview NNS cord-325712-9kbnyqt3 144 5 of of IN cord-325712-9kbnyqt3 144 6 a a DT cord-325712-9kbnyqt3 144 7 selection selection NN cord-325712-9kbnyqt3 144 8 of of IN cord-325712-9kbnyqt3 144 9 ensemble ensemble JJ cord-325712-9kbnyqt3 144 10 methods method NNS cord-325712-9kbnyqt3 144 11 to to TO cord-325712-9kbnyqt3 144 12 appreciate appreciate VB cord-325712-9kbnyqt3 144 13 the the DT cord-325712-9kbnyqt3 144 14 synergy synergy NN cord-325712-9kbnyqt3 144 15 between between IN cord-325712-9kbnyqt3 144 16 the the DT cord-325712-9kbnyqt3 144 17 data datum NNS cord-325712-9kbnyqt3 144 18 collected collect VBN cord-325712-9kbnyqt3 144 19 by by IN cord-325712-9kbnyqt3 144 20 the the DT cord-325712-9kbnyqt3 144 21 different different JJ cord-325712-9kbnyqt3 144 22 techniques technique NNS cord-325712-9kbnyqt3 144 23 in in IN cord-325712-9kbnyqt3 144 24 providing provide VBG cord-325712-9kbnyqt3 144 25 a a DT cord-325712-9kbnyqt3 144 26 complete complete JJ cord-325712-9kbnyqt3 144 27 description description NN cord-325712-9kbnyqt3 144 28 of of IN cord-325712-9kbnyqt3 144 29 virus virus NN cord-325712-9kbnyqt3 144 30 entry entry NN cord-325712-9kbnyqt3 144 31 . . . cord-325712-9kbnyqt3 145 1 Table table NN cord-325712-9kbnyqt3 145 2 2 2 CD cord-325712-9kbnyqt3 145 3 .1 .1 NFP cord-325712-9kbnyqt3 145 4 provides provide VBZ cord-325712-9kbnyqt3 145 5 a a DT cord-325712-9kbnyqt3 145 6 quick quick JJ cord-325712-9kbnyqt3 145 7 reference reference NN cord-325712-9kbnyqt3 145 8 of of IN cord-325712-9kbnyqt3 145 9 techniques technique NNS cord-325712-9kbnyqt3 145 10 and and CC cord-325712-9kbnyqt3 145 11 the the DT cord-325712-9kbnyqt3 145 12 data datum NNS cord-325712-9kbnyqt3 145 13 that that WDT cord-325712-9kbnyqt3 145 14 can can MD cord-325712-9kbnyqt3 145 15 be be VB cord-325712-9kbnyqt3 145 16 obtained obtain VBN cord-325712-9kbnyqt3 145 17 in in IN cord-325712-9kbnyqt3 145 18 each each DT cord-325712-9kbnyqt3 145 19 approach approach NN cord-325712-9kbnyqt3 145 20 for for IN cord-325712-9kbnyqt3 145 21 each each DT cord-325712-9kbnyqt3 145 22 entry entry NN cord-325712-9kbnyqt3 145 23 stage stage NN cord-325712-9kbnyqt3 145 24 . . . cord-325712-9kbnyqt3 146 1 There there EX cord-325712-9kbnyqt3 146 2 are be VBP cord-325712-9kbnyqt3 146 3 two two CD cord-325712-9kbnyqt3 146 4 scales scale NNS cord-325712-9kbnyqt3 146 5 of of IN cord-325712-9kbnyqt3 146 6 transport transport NN cord-325712-9kbnyqt3 146 7 to to TO cord-325712-9kbnyqt3 146 8 be be VB cord-325712-9kbnyqt3 146 9 observed observe VBN cord-325712-9kbnyqt3 146 10 during during IN cord-325712-9kbnyqt3 146 11 virus virus NN cord-325712-9kbnyqt3 146 12 spread spread NN cord-325712-9kbnyqt3 146 13 and and CC cord-325712-9kbnyqt3 146 14 infection infection NN cord-325712-9kbnyqt3 146 15 . . . cord-325712-9kbnyqt3 147 1 On on IN cord-325712-9kbnyqt3 147 2 the the DT cord-325712-9kbnyqt3 147 3 larger large JJR cord-325712-9kbnyqt3 147 4 scale scale NN cord-325712-9kbnyqt3 147 5 is be VBZ cord-325712-9kbnyqt3 147 6 the the DT cord-325712-9kbnyqt3 147 7 transport transport NN cord-325712-9kbnyqt3 147 8 and and CC cord-325712-9kbnyqt3 147 9 spread spread NN cord-325712-9kbnyqt3 147 10 of of IN cord-325712-9kbnyqt3 147 11 virions virion NNS cord-325712-9kbnyqt3 147 12 between between IN cord-325712-9kbnyqt3 147 13 neighboring neighboring NN cord-325712-9kbnyqt3 147 14 cells cell NNS cord-325712-9kbnyqt3 147 15 . . . cord-325712-9kbnyqt3 148 1 Also also RB cord-325712-9kbnyqt3 148 2 of of IN cord-325712-9kbnyqt3 148 3 interest interest NN cord-325712-9kbnyqt3 148 4 is be VBZ cord-325712-9kbnyqt3 148 5 the the DT cord-325712-9kbnyqt3 148 6 smaller small JJR cord-325712-9kbnyqt3 148 7 - - HYPH cord-325712-9kbnyqt3 148 8 scale scale NN cord-325712-9kbnyqt3 148 9 tracking tracking NN cord-325712-9kbnyqt3 148 10 of of IN cord-325712-9kbnyqt3 148 11 an an DT cord-325712-9kbnyqt3 148 12 individual individual JJ cord-325712-9kbnyqt3 148 13 virion virion NN cord-325712-9kbnyqt3 148 14 on on IN cord-325712-9kbnyqt3 148 15 a a DT cord-325712-9kbnyqt3 148 16 cell cell NN cord-325712-9kbnyqt3 148 17 plasma plasma NN cord-325712-9kbnyqt3 148 18 surface surface NN cord-325712-9kbnyqt3 148 19 before before IN cord-325712-9kbnyqt3 148 20 it -PRON- PRP cord-325712-9kbnyqt3 148 21 is be VBZ cord-325712-9kbnyqt3 148 22 internalized internalize VBN cord-325712-9kbnyqt3 148 23 by by IN cord-325712-9kbnyqt3 148 24 that that DT cord-325712-9kbnyqt3 148 25 particular particular JJ cord-325712-9kbnyqt3 148 26 cell cell NN cord-325712-9kbnyqt3 148 27 . . . cord-325712-9kbnyqt3 149 1 In in IN cord-325712-9kbnyqt3 149 2 the the DT cord-325712-9kbnyqt3 149 3 following following JJ cord-325712-9kbnyqt3 149 4 sections section NNS cord-325712-9kbnyqt3 149 5 , , , cord-325712-9kbnyqt3 149 6 experiments experiment NNS cord-325712-9kbnyqt3 149 7 at at IN cord-325712-9kbnyqt3 149 8 each each DT cord-325712-9kbnyqt3 149 9 scale scale NN cord-325712-9kbnyqt3 149 10 will will MD cord-325712-9kbnyqt3 149 11 be be VB cord-325712-9kbnyqt3 149 12 described describe VBN cord-325712-9kbnyqt3 149 13 with with IN cord-325712-9kbnyqt3 149 14 selected select VBN cord-325712-9kbnyqt3 149 15 examples example NNS cord-325712-9kbnyqt3 149 16 and and CC cord-325712-9kbnyqt3 149 17 references reference NNS cord-325712-9kbnyqt3 149 18 . . . cord-325712-9kbnyqt3 150 1 Tracking track VBG cord-325712-9kbnyqt3 150 2 virion virion NN cord-325712-9kbnyqt3 150 3 movement movement NN cord-325712-9kbnyqt3 150 4 in in IN cord-325712-9kbnyqt3 150 5 the the DT cord-325712-9kbnyqt3 150 6 in in IN cord-325712-9kbnyqt3 150 7 vivo vivo NN cord-325712-9kbnyqt3 150 8 environment environment NN cord-325712-9kbnyqt3 150 9 has have VBZ cord-325712-9kbnyqt3 150 10 revealed reveal VBN cord-325712-9kbnyqt3 150 11 various various JJ cord-325712-9kbnyqt3 150 12 avenues avenue NNS cord-325712-9kbnyqt3 150 13 of of IN cord-325712-9kbnyqt3 150 14 virus virus NN cord-325712-9kbnyqt3 150 15 spread spread VBN cord-325712-9kbnyqt3 150 16 to to IN cord-325712-9kbnyqt3 150 17 surrounding surround VBG cord-325712-9kbnyqt3 150 18 cells cell NNS cord-325712-9kbnyqt3 150 19 . . . cord-325712-9kbnyqt3 151 1 The the DT cord-325712-9kbnyqt3 151 2 predominant predominant JJ cord-325712-9kbnyqt3 151 3 transport transport NN cord-325712-9kbnyqt3 151 4 mechanisms mechanism NNS cord-325712-9kbnyqt3 151 5 of of IN cord-325712-9kbnyqt3 151 6 virus virus NN cord-325712-9kbnyqt3 151 7 spread spread VBN cord-325712-9kbnyqt3 151 8 between between IN cord-325712-9kbnyqt3 151 9 cells cell NNS cord-325712-9kbnyqt3 151 10 are be VBP cord-325712-9kbnyqt3 151 11 : : : cord-325712-9kbnyqt3 151 12 ( ( -LRB- cord-325712-9kbnyqt3 151 13 1 1 LS cord-325712-9kbnyqt3 151 14 ) ) -RRB- cord-325712-9kbnyqt3 151 15 virions virion NNS cord-325712-9kbnyqt3 151 16 freely freely RB cord-325712-9kbnyqt3 151 17 diffusing diffuse VBG cord-325712-9kbnyqt3 151 18 through through IN cord-325712-9kbnyqt3 151 19 the the DT cord-325712-9kbnyqt3 151 20 extracellular extracellular JJ cord-325712-9kbnyqt3 151 21 environment environment NN cord-325712-9kbnyqt3 151 22 to to IN cord-325712-9kbnyqt3 151 23 neighboring neighboring NN cord-325712-9kbnyqt3 151 24 cell cell NN cord-325712-9kbnyqt3 151 25 surfaces surface NNS cord-325712-9kbnyqt3 151 26 , , , cord-325712-9kbnyqt3 151 27 or or CC cord-325712-9kbnyqt3 151 28 ( ( -LRB- cord-325712-9kbnyqt3 151 29 2 2 LS cord-325712-9kbnyqt3 151 30 ) ) -RRB- cord-325712-9kbnyqt3 151 31 spreading spread VBG cord-325712-9kbnyqt3 151 32 to to IN cord-325712-9kbnyqt3 151 33 neighboring neighboring NN cord-325712-9kbnyqt3 151 34 cells cell NNS cord-325712-9kbnyqt3 151 35 through through IN cord-325712-9kbnyqt3 151 36 direct direct JJ cord-325712-9kbnyqt3 151 37 transmission transmission NN cord-325712-9kbnyqt3 151 38 across across IN cord-325712-9kbnyqt3 151 39 adjoining adjoin VBG cord-325712-9kbnyqt3 151 40 membranes membrane NNS cord-325712-9kbnyqt3 151 41 . . . cord-325712-9kbnyqt3 152 1 For for IN cord-325712-9kbnyqt3 152 2 the the DT cord-325712-9kbnyqt3 152 3 first first JJ cord-325712-9kbnyqt3 152 4 mechanism mechanism NN cord-325712-9kbnyqt3 152 5 , , , cord-325712-9kbnyqt3 152 6 the the DT cord-325712-9kbnyqt3 152 7 mean mean JJ cord-325712-9kbnyqt3 152 8 - - HYPH cord-325712-9kbnyqt3 152 9 squared squared JJ cord-325712-9kbnyqt3 152 10 displacement displacement NN cord-325712-9kbnyqt3 152 11 of of IN cord-325712-9kbnyqt3 152 12 virions virion NNS cord-325712-9kbnyqt3 152 13 over over IN cord-325712-9kbnyqt3 152 14 time time NN cord-325712-9kbnyqt3 152 15 is be VBZ cord-325712-9kbnyqt3 152 16 used use VBN cord-325712-9kbnyqt3 152 17 to to TO cord-325712-9kbnyqt3 152 18 classify classify VB cord-325712-9kbnyqt3 152 19 their -PRON- PRP$ cord-325712-9kbnyqt3 152 20 motion motion NN cord-325712-9kbnyqt3 152 21 as as IN cord-325712-9kbnyqt3 152 22 diffusive diffusive JJ cord-325712-9kbnyqt3 152 23 or or CC cord-325712-9kbnyqt3 152 24 sub sub JJ cord-325712-9kbnyqt3 152 25 - - JJ cord-325712-9kbnyqt3 152 26 diffusive diffusive JJ cord-325712-9kbnyqt3 152 27 through through IN cord-325712-9kbnyqt3 152 28 the the DT cord-325712-9kbnyqt3 152 29 extracellular extracellular JJ cord-325712-9kbnyqt3 152 30 environment environment NN cord-325712-9kbnyqt3 152 31 . . . cord-325712-9kbnyqt3 153 1 For for IN cord-325712-9kbnyqt3 153 2 example example NN cord-325712-9kbnyqt3 153 3 , , , cord-325712-9kbnyqt3 153 4 live live JJ cord-325712-9kbnyqt3 153 5 cell cell NN cord-325712-9kbnyqt3 153 6 single single JJ cord-325712-9kbnyqt3 153 7 virion virion NN cord-325712-9kbnyqt3 153 8 tracking tracking NN cord-325712-9kbnyqt3 153 9 of of IN cord-325712-9kbnyqt3 153 10 adeno adeno NN cord-325712-9kbnyqt3 153 11 - - HYPH cord-325712-9kbnyqt3 153 12 associated associate VBN cord-325712-9kbnyqt3 153 13 viruses virus NNS cord-325712-9kbnyqt3 153 14 [ [ -LRB- cord-325712-9kbnyqt3 153 15 17 17 CD cord-325712-9kbnyqt3 153 16 ] ] -RRB- cord-325712-9kbnyqt3 153 17 and and CC cord-325712-9kbnyqt3 153 18 simian simian JJ cord-325712-9kbnyqt3 153 19 virus virus NN cord-325712-9kbnyqt3 153 20 40 40 CD cord-325712-9kbnyqt3 153 21 virus virus NN cord-325712-9kbnyqt3 153 22 - - HYPH cord-325712-9kbnyqt3 153 23 like like JJ cord-325712-9kbnyqt3 153 24 particles particle NNS cord-325712-9kbnyqt3 153 25 [ [ -LRB- cord-325712-9kbnyqt3 153 26 62 62 CD cord-325712-9kbnyqt3 153 27 ] ] -RRB- cord-325712-9kbnyqt3 153 28 indicates indicate VBZ cord-325712-9kbnyqt3 153 29 that that IN cord-325712-9kbnyqt3 153 30 particles particle NNS cord-325712-9kbnyqt3 153 31 undergo undergo VBP cord-325712-9kbnyqt3 153 32 normal normal JJ cord-325712-9kbnyqt3 153 33 diffusion diffusion NN cord-325712-9kbnyqt3 153 34 in in IN cord-325712-9kbnyqt3 153 35 the the DT cord-325712-9kbnyqt3 153 36 extracellular extracellular JJ cord-325712-9kbnyqt3 153 37 environment environment NN cord-325712-9kbnyqt3 153 38 . . . cord-325712-9kbnyqt3 154 1 Adeno Adeno NNP cord-325712-9kbnyqt3 154 2 - - HYPH cord-325712-9kbnyqt3 154 3 associated associate VBN cord-325712-9kbnyqt3 154 4 viruses virus NNS cord-325712-9kbnyqt3 154 5 slow slow VBP cord-325712-9kbnyqt3 154 6 down down RP cord-325712-9kbnyqt3 154 7 when when WRB cord-325712-9kbnyqt3 154 8 in in IN cord-325712-9kbnyqt3 154 9 the the DT cord-325712-9kbnyqt3 154 10 vicinity vicinity NN cord-325712-9kbnyqt3 154 11 of of IN cord-325712-9kbnyqt3 154 12 a a DT cord-325712-9kbnyqt3 154 13 cell cell NN cord-325712-9kbnyqt3 154 14 , , , cord-325712-9kbnyqt3 154 15 and and CC cord-325712-9kbnyqt3 154 16 touch touch VB cord-325712-9kbnyqt3 154 17 the the DT cord-325712-9kbnyqt3 154 18 cell cell NN cord-325712-9kbnyqt3 154 19 membrane membrane NN cord-325712-9kbnyqt3 154 20 multiple multiple JJ cord-325712-9kbnyqt3 154 21 times time NNS cord-325712-9kbnyqt3 154 22 before before IN cord-325712-9kbnyqt3 154 23 penetrating penetrate VBG cord-325712-9kbnyqt3 154 24 the the DT cord-325712-9kbnyqt3 154 25 cell cell NN cord-325712-9kbnyqt3 154 26 [ [ -LRB- cord-325712-9kbnyqt3 154 27 17 17 CD cord-325712-9kbnyqt3 154 28 ] ] -RRB- cord-325712-9kbnyqt3 154 29 . . . cord-325712-9kbnyqt3 155 1 In in IN cord-325712-9kbnyqt3 155 2 contrast contrast NN cord-325712-9kbnyqt3 155 3 , , , cord-325712-9kbnyqt3 155 4 HIV HIV NNP cord-325712-9kbnyqt3 155 5 follows follow VBZ cord-325712-9kbnyqt3 155 6 the the DT cord-325712-9kbnyqt3 155 7 second second JJ cord-325712-9kbnyqt3 155 8 mechanism mechanism NN cord-325712-9kbnyqt3 155 9 and and CC cord-325712-9kbnyqt3 155 10 preferentially preferentially RB cord-325712-9kbnyqt3 155 11 transmits transmit VBZ cord-325712-9kbnyqt3 155 12 directly directly RB cord-325712-9kbnyqt3 155 13 from from IN cord-325712-9kbnyqt3 155 14 one one CD cord-325712-9kbnyqt3 155 15 neighboring neighbor VBG cord-325712-9kbnyqt3 155 16 cell cell NN cord-325712-9kbnyqt3 155 17 to to IN cord-325712-9kbnyqt3 155 18 another another DT cord-325712-9kbnyqt3 155 19 through through IN cord-325712-9kbnyqt3 155 20 virological virological JJ cord-325712-9kbnyqt3 155 21 synapses synapsis NNS cord-325712-9kbnyqt3 155 22 rather rather RB cord-325712-9kbnyqt3 155 23 than than IN cord-325712-9kbnyqt3 155 24 transmission transmission NN cord-325712-9kbnyqt3 155 25 by by IN cord-325712-9kbnyqt3 155 26 extracellular extracellular JJ cord-325712-9kbnyqt3 155 27 diffusion diffusion NN cord-325712-9kbnyqt3 155 28 [ [ -LRB- cord-325712-9kbnyqt3 155 29 63 63 CD cord-325712-9kbnyqt3 155 30 ] ] -RRB- cord-325712-9kbnyqt3 155 31 [ [ -LRB- cord-325712-9kbnyqt3 155 32 64 64 CD cord-325712-9kbnyqt3 155 33 ] ] -RRB- cord-325712-9kbnyqt3 156 1 [ [ -LRB- cord-325712-9kbnyqt3 156 2 65 65 CD cord-325712-9kbnyqt3 156 3 ] ] -RRB- cord-325712-9kbnyqt3 157 1 Some some DT cord-325712-9kbnyqt3 157 2 viruses virus NNS cord-325712-9kbnyqt3 157 3 exploit exploit VBP cord-325712-9kbnyqt3 157 4 cytoskeletal cytoskeletal JJ cord-325712-9kbnyqt3 157 5 components component NNS cord-325712-9kbnyqt3 157 6 to to TO cord-325712-9kbnyqt3 157 7 facilitate facilitate VB cord-325712-9kbnyqt3 157 8 transport transport NN cord-325712-9kbnyqt3 157 9 from from IN cord-325712-9kbnyqt3 157 10 one one CD cord-325712-9kbnyqt3 157 11 cell cell NN cord-325712-9kbnyqt3 157 12 to to IN cord-325712-9kbnyqt3 157 13 another another DT cord-325712-9kbnyqt3 157 14 . . . cord-325712-9kbnyqt3 158 1 Vaccinia vaccinia NN cord-325712-9kbnyqt3 158 2 virus virus NN cord-325712-9kbnyqt3 158 3 , , , cord-325712-9kbnyqt3 158 4 for for IN cord-325712-9kbnyqt3 158 5 • • NNP cord-325712-9kbnyqt3 158 6 Cytoskeletal Cytoskeletal NNP cord-325712-9kbnyqt3 158 7 interaction interaction NN cord-325712-9kbnyqt3 159 1 • • NNP cord-325712-9kbnyqt3 160 1 Extra extra JJ cord-325712-9kbnyqt3 160 2 - - JJ cord-325712-9kbnyqt3 160 3 and and CC cord-325712-9kbnyqt3 160 4 intra intra JJ cord-325712-9kbnyqt3 160 5 - - JJ cord-325712-9kbnyqt3 160 6 nuclear nuclear JJ cord-325712-9kbnyqt3 160 7 movement movement NN cord-325712-9kbnyqt3 161 1 n n LS cord-325712-9kbnyqt3 161 2 / / SYM cord-325712-9kbnyqt3 161 3 a a DT cord-325712-9kbnyqt3 161 4 IFA IFA NNP cord-325712-9kbnyqt3 161 5 Acronyms Acronyms NNP cord-325712-9kbnyqt3 161 6 : : : cord-325712-9kbnyqt3 162 1 QCMD QCMD NNP cord-325712-9kbnyqt3 162 2 Quartz Quartz NNP cord-325712-9kbnyqt3 162 3 crystal crystal NN cord-325712-9kbnyqt3 162 4 microbalance microbalance NN cord-325712-9kbnyqt3 162 5 with with IN cord-325712-9kbnyqt3 162 6 dissipation dissipation NN cord-325712-9kbnyqt3 163 1 , , , cord-325712-9kbnyqt3 163 2 ELISA ELISA NNP cord-325712-9kbnyqt3 163 3 Enzyme Enzyme NNP cord-325712-9kbnyqt3 163 4 - - HYPH cord-325712-9kbnyqt3 163 5 linked link VBN cord-325712-9kbnyqt3 163 6 immunosorbent immunosorbent JJ cord-325712-9kbnyqt3 163 7 assay assay NN cord-325712-9kbnyqt3 163 8 , , , cord-325712-9kbnyqt3 163 9 SPR SPR NNP cord-325712-9kbnyqt3 163 10 Surface Surface NNP cord-325712-9kbnyqt3 163 11 plasmon plasmon JJ cord-325712-9kbnyqt3 163 12 resonance resonance NN cord-325712-9kbnyqt3 163 13 , , , cord-325712-9kbnyqt3 163 14 TEM tem NN cord-325712-9kbnyqt3 163 15 Transmission transmission NN cord-325712-9kbnyqt3 163 16 electron electron NN cord-325712-9kbnyqt3 163 17 microscopy microscopy NN cord-325712-9kbnyqt3 163 18 , , , cord-325712-9kbnyqt3 163 19 IFA IFA NNP cord-325712-9kbnyqt3 163 20 immunofluoresence immunofluoresence NN cord-325712-9kbnyqt3 163 21 assay assay NN cord-325712-9kbnyqt3 163 22 , , , cord-325712-9kbnyqt3 163 23 BlaM BlaM NNP cord-325712-9kbnyqt3 163 24 Beta beta JJ cord-325712-9kbnyqt3 163 25 lactamase lactamase NN cord-325712-9kbnyqt3 163 26 example example NN cord-325712-9kbnyqt3 163 27 , , , cord-325712-9kbnyqt3 163 28 induces induce VBZ cord-325712-9kbnyqt3 163 29 the the DT cord-325712-9kbnyqt3 163 30 formation formation NN cord-325712-9kbnyqt3 163 31 of of IN cord-325712-9kbnyqt3 163 32 actin actin NN cord-325712-9kbnyqt3 163 33 protrusions protrusion NNS cord-325712-9kbnyqt3 163 34 from from IN cord-325712-9kbnyqt3 163 35 the the DT cord-325712-9kbnyqt3 163 36 cell cell NN cord-325712-9kbnyqt3 163 37 surface surface NN cord-325712-9kbnyqt3 163 38 and and CC cord-325712-9kbnyqt3 163 39 is be VBZ cord-325712-9kbnyqt3 163 40 transported transport VBN cord-325712-9kbnyqt3 163 41 along along IN cord-325712-9kbnyqt3 163 42 these these DT cord-325712-9kbnyqt3 163 43 to to TO cord-325712-9kbnyqt3 163 44 spread spread VB cord-325712-9kbnyqt3 163 45 from from IN cord-325712-9kbnyqt3 163 46 cell cell NN cord-325712-9kbnyqt3 163 47 to to IN cord-325712-9kbnyqt3 163 48 cell cell NN cord-325712-9kbnyqt3 163 49 [ [ -LRB- cord-325712-9kbnyqt3 163 50 66 66 CD cord-325712-9kbnyqt3 163 51 ] ] -RRB- cord-325712-9kbnyqt3 163 52 . . . cord-325712-9kbnyqt3 164 1 Looking look VBG cord-325712-9kbnyqt3 164 2 at at IN cord-325712-9kbnyqt3 164 3 viral viral JJ cord-325712-9kbnyqt3 164 4 transport transport NN cord-325712-9kbnyqt3 164 5 over over IN cord-325712-9kbnyqt3 164 6 a a DT cord-325712-9kbnyqt3 164 7 longer long JJR cord-325712-9kbnyqt3 164 8 distance distance NN cord-325712-9kbnyqt3 164 9 scale scale NN cord-325712-9kbnyqt3 164 10 , , , cord-325712-9kbnyqt3 164 11 single single JJ cord-325712-9kbnyqt3 164 12 virion virion NN cord-325712-9kbnyqt3 164 13 imaging imaging NN cord-325712-9kbnyqt3 164 14 has have VBZ cord-325712-9kbnyqt3 164 15 shown show VBN cord-325712-9kbnyqt3 164 16 that that IN cord-325712-9kbnyqt3 164 17 pseudorabies pseudorabies NN cord-325712-9kbnyqt3 164 18 virus virus NN cord-325712-9kbnyqt3 164 19 is be VBZ cord-325712-9kbnyqt3 164 20 able able JJ cord-325712-9kbnyqt3 164 21 to to TO cord-325712-9kbnyqt3 164 22 spread spread VB cord-325712-9kbnyqt3 164 23 from from IN cord-325712-9kbnyqt3 164 24 the the DT cord-325712-9kbnyqt3 164 25 site site NN cord-325712-9kbnyqt3 164 26 of of IN cord-325712-9kbnyqt3 164 27 infection infection NN cord-325712-9kbnyqt3 164 28 to to IN cord-325712-9kbnyqt3 164 29 the the DT cord-325712-9kbnyqt3 164 30 peripheral peripheral JJ cord-325712-9kbnyqt3 164 31 nervous nervous JJ cord-325712-9kbnyqt3 164 32 system system NN cord-325712-9kbnyqt3 164 33 ganglia ganglion NNS cord-325712-9kbnyqt3 164 34 for for IN cord-325712-9kbnyqt3 164 35 replication replication NN cord-325712-9kbnyqt3 164 36 then then RB cord-325712-9kbnyqt3 164 37 back back RB cord-325712-9kbnyqt3 164 38 along along IN cord-325712-9kbnyqt3 164 39 axons axon NNS cord-325712-9kbnyqt3 164 40 to to TO cord-325712-9kbnyqt3 164 41 reseed reseed VB cord-325712-9kbnyqt3 164 42 the the DT cord-325712-9kbnyqt3 164 43 initial initial JJ cord-325712-9kbnyqt3 164 44 infection infection NN cord-325712-9kbnyqt3 164 45 site site NN cord-325712-9kbnyqt3 164 46 [ [ -LRB- cord-325712-9kbnyqt3 164 47 67 67 CD cord-325712-9kbnyqt3 164 48 ] ] -RRB- cord-325712-9kbnyqt3 164 49 . . . cord-325712-9kbnyqt3 165 1 In in IN cord-325712-9kbnyqt3 165 2 vitro vitro FW cord-325712-9kbnyqt3 165 3 experiments experiment NNS cord-325712-9kbnyqt3 165 4 have have VBP cord-325712-9kbnyqt3 165 5 been be VBN cord-325712-9kbnyqt3 165 6 used use VBN cord-325712-9kbnyqt3 165 7 to to TO cord-325712-9kbnyqt3 165 8 study study VB cord-325712-9kbnyqt3 165 9 how how WRB cord-325712-9kbnyqt3 165 10 respiratory respiratory JJ cord-325712-9kbnyqt3 165 11 mucosa mucosa NN cord-325712-9kbnyqt3 165 12 hinders hinder VBZ cord-325712-9kbnyqt3 165 13 the the DT cord-325712-9kbnyqt3 165 14 ability ability NN cord-325712-9kbnyqt3 165 15 of of IN cord-325712-9kbnyqt3 165 16 pseudorabies pseudorabies NN cord-325712-9kbnyqt3 165 17 virus virus NN cord-325712-9kbnyqt3 165 18 to to TO cord-325712-9kbnyqt3 165 19 cross cross VB cord-325712-9kbnyqt3 165 20 into into IN cord-325712-9kbnyqt3 165 21 the the DT cord-325712-9kbnyqt3 165 22 epithelium epithelium NN cord-325712-9kbnyqt3 165 23 , , , cord-325712-9kbnyqt3 165 24 revealing reveal VBG cord-325712-9kbnyqt3 165 25 that that IN cord-325712-9kbnyqt3 165 26 both both DT cord-325712-9kbnyqt3 165 27 size size NN cord-325712-9kbnyqt3 165 28 and and CC cord-325712-9kbnyqt3 165 29 charge charge NN cord-325712-9kbnyqt3 165 30 interactions interaction NNS cord-325712-9kbnyqt3 165 31 are be VBP cord-325712-9kbnyqt3 165 32 important important JJ cord-325712-9kbnyqt3 165 33 [ [ -LRB- cord-325712-9kbnyqt3 165 34 68 68 CD cord-325712-9kbnyqt3 165 35 ] ] -RRB- cord-325712-9kbnyqt3 165 36 . . . cord-325712-9kbnyqt3 166 1 There there EX cord-325712-9kbnyqt3 166 2 are be VBP cord-325712-9kbnyqt3 166 3 multiple multiple JJ cord-325712-9kbnyqt3 166 4 strategies strategy NNS cord-325712-9kbnyqt3 166 5 for for IN cord-325712-9kbnyqt3 166 6 observing observe VBG cord-325712-9kbnyqt3 166 7 lateral lateral JJ cord-325712-9kbnyqt3 166 8 viral viral JJ cord-325712-9kbnyqt3 166 9 movement movement NN cord-325712-9kbnyqt3 166 10 along along IN cord-325712-9kbnyqt3 166 11 the the DT cord-325712-9kbnyqt3 166 12 plasma plasma NN cord-325712-9kbnyqt3 166 13 membrane membrane NN cord-325712-9kbnyqt3 166 14 of of IN cord-325712-9kbnyqt3 166 15 a a DT cord-325712-9kbnyqt3 166 16 live live JJ cord-325712-9kbnyqt3 166 17 cell cell NN cord-325712-9kbnyqt3 166 18 . . . cord-325712-9kbnyqt3 167 1 One one CD cord-325712-9kbnyqt3 167 2 method method NN cord-325712-9kbnyqt3 167 3 is be VBZ cord-325712-9kbnyqt3 167 4 labeling label VBG cord-325712-9kbnyqt3 167 5 the the DT cord-325712-9kbnyqt3 167 6 core core NN cord-325712-9kbnyqt3 167 7 of of IN cord-325712-9kbnyqt3 167 8 virions virion NNS cord-325712-9kbnyqt3 167 9 and and CC cord-325712-9kbnyqt3 167 10 cellular cellular JJ cord-325712-9kbnyqt3 167 11 actin actin NN cord-325712-9kbnyqt3 167 12 ( ( -LRB- cord-325712-9kbnyqt3 167 13 to to TO cord-325712-9kbnyqt3 167 14 delineate delineate VB cord-325712-9kbnyqt3 167 15 the the DT cord-325712-9kbnyqt3 167 16 border border NN cord-325712-9kbnyqt3 167 17 of of IN cord-325712-9kbnyqt3 167 18 cells cell NNS cord-325712-9kbnyqt3 167 19 ) ) -RRB- cord-325712-9kbnyqt3 167 20 and and CC cord-325712-9kbnyqt3 167 21 track track NN cord-325712-9kbnyqt3 167 22 virion virion NN cord-325712-9kbnyqt3 167 23 movement movement NN cord-325712-9kbnyqt3 167 24 along along IN cord-325712-9kbnyqt3 167 25 the the DT cord-325712-9kbnyqt3 167 26 periphery periphery NN cord-325712-9kbnyqt3 167 27 of of IN cord-325712-9kbnyqt3 167 28 the the DT cord-325712-9kbnyqt3 167 29 cell cell NN cord-325712-9kbnyqt3 167 30 [ [ -LRB- cord-325712-9kbnyqt3 167 31 69 69 CD cord-325712-9kbnyqt3 167 32 ] ] -RRB- cord-325712-9kbnyqt3 167 33 . . . cord-325712-9kbnyqt3 168 1 Another another DT cord-325712-9kbnyqt3 168 2 method method NN cord-325712-9kbnyqt3 168 3 is be VBZ cord-325712-9kbnyqt3 168 4 to to TO cord-325712-9kbnyqt3 168 5 label label VB cord-325712-9kbnyqt3 168 6 the the DT cord-325712-9kbnyqt3 168 7 viral viral JJ cord-325712-9kbnyqt3 168 8 membrane membrane NN cord-325712-9kbnyqt3 168 9 and and CC cord-325712-9kbnyqt3 168 10 look look VB cord-325712-9kbnyqt3 168 11 at at IN cord-325712-9kbnyqt3 168 12 diffusion diffusion NN cord-325712-9kbnyqt3 168 13 on on IN cord-325712-9kbnyqt3 168 14 top top NN cord-325712-9kbnyqt3 168 15 of of IN cord-325712-9kbnyqt3 168 16 membrane membrane NN cord-325712-9kbnyqt3 168 17 until until IN cord-325712-9kbnyqt3 168 18 the the DT cord-325712-9kbnyqt3 168 19 virion virion NN cord-325712-9kbnyqt3 168 20 overlaps overlap VBZ cord-325712-9kbnyqt3 168 21 with with IN cord-325712-9kbnyqt3 168 22 an an DT cord-325712-9kbnyqt3 168 23 endocytosis endocytosis NN cord-325712-9kbnyqt3 168 24 site site NN cord-325712-9kbnyqt3 168 25 [ [ -LRB- cord-325712-9kbnyqt3 168 26 70 70 CD cord-325712-9kbnyqt3 168 27 ] ] -RRB- cord-325712-9kbnyqt3 168 28 . . . cord-325712-9kbnyqt3 169 1 A a DT cord-325712-9kbnyqt3 169 2 few few JJ cord-325712-9kbnyqt3 169 3 examples example NNS cord-325712-9kbnyqt3 169 4 of of IN cord-325712-9kbnyqt3 169 5 virion virion NN cord-325712-9kbnyqt3 169 6 movement movement NN cord-325712-9kbnyqt3 169 7 that that WDT cord-325712-9kbnyqt3 169 8 have have VBP cord-325712-9kbnyqt3 169 9 been be VBN cord-325712-9kbnyqt3 169 10 studied study VBN cord-325712-9kbnyqt3 169 11 this this DT cord-325712-9kbnyqt3 169 12 way way NN cord-325712-9kbnyqt3 169 13 are be VBP cord-325712-9kbnyqt3 169 14 as as IN cord-325712-9kbnyqt3 169 15 follows follow VBZ cord-325712-9kbnyqt3 169 16 . . . cord-325712-9kbnyqt3 170 1 Simian simian JJ cord-325712-9kbnyqt3 170 2 virus virus NN cord-325712-9kbnyqt3 170 3 40 40 CD cord-325712-9kbnyqt3 170 4 undergoes undergo VBZ cord-325712-9kbnyqt3 170 5 actin actin JJ cord-325712-9kbnyqt3 170 6 independent independent JJ cord-325712-9kbnyqt3 170 7 diffusive diffusive JJ cord-325712-9kbnyqt3 170 8 movement movement NN cord-325712-9kbnyqt3 170 9 on on IN cord-325712-9kbnyqt3 170 10 the the DT cord-325712-9kbnyqt3 170 11 cell cell NN cord-325712-9kbnyqt3 170 12 membrane membrane NN cord-325712-9kbnyqt3 170 13 until until IN cord-325712-9kbnyqt3 170 14 it -PRON- PRP cord-325712-9kbnyqt3 170 15 reaches reach VBZ cord-325712-9kbnyqt3 170 16 caveolae caveolae NNP cord-325712-9kbnyqt3 170 17 [ [ -LRB- cord-325712-9kbnyqt3 170 18 71 71 CD cord-325712-9kbnyqt3 170 19 ] ] -RRB- cord-325712-9kbnyqt3 170 20 . . . cord-325712-9kbnyqt3 171 1 Dengue dengue NN cord-325712-9kbnyqt3 171 2 virus virus NN cord-325712-9kbnyqt3 171 3 similarly similarly RB cord-325712-9kbnyqt3 171 4 freely freely RB cord-325712-9kbnyqt3 171 5 diffuses diffuse VBZ cord-325712-9kbnyqt3 171 6 on on IN cord-325712-9kbnyqt3 171 7 the the DT cord-325712-9kbnyqt3 171 8 membrane membrane NN cord-325712-9kbnyqt3 171 9 until until IN cord-325712-9kbnyqt3 171 10 it -PRON- PRP cord-325712-9kbnyqt3 171 11 reaches reach VBZ cord-325712-9kbnyqt3 171 12 an an DT cord-325712-9kbnyqt3 171 13 existing exist VBG cord-325712-9kbnyqt3 171 14 clathrin clathrin NN cord-325712-9kbnyqt3 171 15 - - HYPH cord-325712-9kbnyqt3 171 16 coated coated JJ cord-325712-9kbnyqt3 171 17 pit pit NN cord-325712-9kbnyqt3 171 18 [ [ -LRB- cord-325712-9kbnyqt3 171 19 70 70 CD cord-325712-9kbnyqt3 171 20 ] ] -RRB- cord-325712-9kbnyqt3 171 21 . . . cord-325712-9kbnyqt3 172 1 Murine murine JJ cord-325712-9kbnyqt3 172 2 polyoma polyoma NN cord-325712-9kbnyqt3 172 3 virus virus NN cord-325712-9kbnyqt3 172 4 - - HYPH cord-325712-9kbnyqt3 172 5 like like JJ cord-325712-9kbnyqt3 172 6 particles particle NNS cord-325712-9kbnyqt3 172 7 also also RB cord-325712-9kbnyqt3 172 8 freely freely RB cord-325712-9kbnyqt3 172 9 diffuse diffuse VBP cord-325712-9kbnyqt3 172 10 at at IN cord-325712-9kbnyqt3 172 11 first first RB cord-325712-9kbnyqt3 172 12 , , , cord-325712-9kbnyqt3 172 13 then then RB cord-325712-9kbnyqt3 172 14 become become VB cord-325712-9kbnyqt3 172 15 confined confine VBN cord-325712-9kbnyqt3 172 16 and and CC cord-325712-9kbnyqt3 172 17 follow follow VB cord-325712-9kbnyqt3 172 18 actin actin NN cord-325712-9kbnyqt3 172 19 - - HYPH cord-325712-9kbnyqt3 172 20 directed direct VBN cord-325712-9kbnyqt3 172 21 trajectories trajectory NNS cord-325712-9kbnyqt3 172 22 afterwards afterwards RB cord-325712-9kbnyqt3 172 23 [ [ -LRB- cord-325712-9kbnyqt3 172 24 72 72 CD cord-325712-9kbnyqt3 172 25 ] ] -RRB- cord-325712-9kbnyqt3 172 26 . . . cord-325712-9kbnyqt3 173 1 Vaccinia vaccinia NN cord-325712-9kbnyqt3 173 2 bound bind VBN cord-325712-9kbnyqt3 173 3 to to IN cord-325712-9kbnyqt3 173 4 filopodia filopodia NNS cord-325712-9kbnyqt3 173 5 have have VBP cord-325712-9kbnyqt3 173 6 been be VBN cord-325712-9kbnyqt3 173 7 observed observe VBN cord-325712-9kbnyqt3 173 8 to to TO cord-325712-9kbnyqt3 173 9 move move VB cord-325712-9kbnyqt3 173 10 towards towards IN cord-325712-9kbnyqt3 173 11 the the DT cord-325712-9kbnyqt3 173 12 cell cell NN cord-325712-9kbnyqt3 173 13 body body NN cord-325712-9kbnyqt3 173 14 along along IN cord-325712-9kbnyqt3 173 15 the the DT cord-325712-9kbnyqt3 173 16 plasma plasma NN cord-325712-9kbnyqt3 173 17 membrane membrane NN cord-325712-9kbnyqt3 173 18 [ [ -LRB- cord-325712-9kbnyqt3 173 19 73 73 CD cord-325712-9kbnyqt3 173 20 ] ] -RRB- cord-325712-9kbnyqt3 173 21 . . . cord-325712-9kbnyqt3 174 1 Some some DT cord-325712-9kbnyqt3 174 2 viruses virus NNS cord-325712-9kbnyqt3 174 3 employ employ VBP cord-325712-9kbnyqt3 174 4 a a DT cord-325712-9kbnyqt3 174 5 mix mix NN cord-325712-9kbnyqt3 174 6 of of IN cord-325712-9kbnyqt3 174 7 two two CD cord-325712-9kbnyqt3 174 8 mechanisms mechanism NNS cord-325712-9kbnyqt3 174 9 , , , cord-325712-9kbnyqt3 174 10 free free JJ cord-325712-9kbnyqt3 174 11 diffusion diffusion NN cord-325712-9kbnyqt3 174 12 and and CC cord-325712-9kbnyqt3 174 13 directed direct VBN cord-325712-9kbnyqt3 174 14 motion motion NN cord-325712-9kbnyqt3 174 15 . . . cord-325712-9kbnyqt3 175 1 Some some DT cord-325712-9kbnyqt3 175 2 examples example NNS cord-325712-9kbnyqt3 175 3 of of IN cord-325712-9kbnyqt3 175 4 this this DT cord-325712-9kbnyqt3 175 5 type type NN cord-325712-9kbnyqt3 175 6 of of IN cord-325712-9kbnyqt3 175 7 movement movement NN cord-325712-9kbnyqt3 175 8 are be VBP cord-325712-9kbnyqt3 175 9 as as IN cord-325712-9kbnyqt3 175 10 follows follow VBZ cord-325712-9kbnyqt3 175 11 . . . cord-325712-9kbnyqt3 176 1 After after IN cord-325712-9kbnyqt3 176 2 binding bind VBG cord-325712-9kbnyqt3 176 3 to to IN cord-325712-9kbnyqt3 176 4 filopodia filopodia NNS cord-325712-9kbnyqt3 176 5 , , , cord-325712-9kbnyqt3 176 6 murine murine JJ cord-325712-9kbnyqt3 176 7 leukemia leukemia NN cord-325712-9kbnyqt3 176 8 virus virus NN cord-325712-9kbnyqt3 176 9 , , , cord-325712-9kbnyqt3 176 10 avian avian JJ cord-325712-9kbnyqt3 176 11 leucosis leucosis NN cord-325712-9kbnyqt3 176 12 virus virus NN cord-325712-9kbnyqt3 176 13 , , , cord-325712-9kbnyqt3 176 14 vesicular vesicular JJ cord-325712-9kbnyqt3 176 15 stomatitis stomatitis NN cord-325712-9kbnyqt3 176 16 virus virus NN cord-325712-9kbnyqt3 176 17 , , , cord-325712-9kbnyqt3 176 18 and and CC cord-325712-9kbnyqt3 176 19 rabies rabies NN cord-325712-9kbnyqt3 176 20 virus virus NN cord-325712-9kbnyqt3 176 21 appear appear VBP cord-325712-9kbnyqt3 176 22 to to TO cord-325712-9kbnyqt3 176 23 " " `` cord-325712-9kbnyqt3 176 24 surf surf VB cord-325712-9kbnyqt3 176 25 " " '' cord-325712-9kbnyqt3 176 26 on on IN cord-325712-9kbnyqt3 176 27 top top NN cord-325712-9kbnyqt3 176 28 of of IN cord-325712-9kbnyqt3 176 29 the the DT cord-325712-9kbnyqt3 176 30 membrane membrane NN cord-325712-9kbnyqt3 176 31 via via IN cord-325712-9kbnyqt3 176 32 actin actin NN cord-325712-9kbnyqt3 176 33 and and CC cord-325712-9kbnyqt3 176 34 myosin myosin NN cord-325712-9kbnyqt3 176 35 II II NNP cord-325712-9kbnyqt3 176 36 driven drive VBN cord-325712-9kbnyqt3 176 37 transport transport NN cord-325712-9kbnyqt3 176 38 towards towards IN cord-325712-9kbnyqt3 176 39 entry entry NN cord-325712-9kbnyqt3 176 40 sites site NNS cord-325712-9kbnyqt3 176 41 [ [ -LRB- cord-325712-9kbnyqt3 176 42 69 69 CD cord-325712-9kbnyqt3 176 43 , , , cord-325712-9kbnyqt3 176 44 74 74 CD cord-325712-9kbnyqt3 176 45 ] ] -RRB- cord-325712-9kbnyqt3 176 46 . . . cord-325712-9kbnyqt3 177 1 Similarly similarly RB cord-325712-9kbnyqt3 177 2 , , , cord-325712-9kbnyqt3 177 3 adenovirus adenovirus NN cord-325712-9kbnyqt3 177 4 binds bind VBZ cord-325712-9kbnyqt3 177 5 its -PRON- PRP$ cord-325712-9kbnyqt3 177 6 receptor receptor NN cord-325712-9kbnyqt3 177 7 then then RB cord-325712-9kbnyqt3 177 8 drifts drift VBZ cord-325712-9kbnyqt3 177 9 along along IN cord-325712-9kbnyqt3 177 10 the the DT cord-325712-9kbnyqt3 177 11 cell cell NN cord-325712-9kbnyqt3 177 12 surface surface NN cord-325712-9kbnyqt3 177 13 with with IN cord-325712-9kbnyqt3 177 14 the the DT cord-325712-9kbnyqt3 177 15 assistance assistance NN cord-325712-9kbnyqt3 177 16 of of IN cord-325712-9kbnyqt3 177 17 actin actin NN cord-325712-9kbnyqt3 177 18 and and CC cord-325712-9kbnyqt3 177 19 myosin myosin NNS cord-325712-9kbnyqt3 177 20 II II NNP cord-325712-9kbnyqt3 177 21 [ [ -LRB- cord-325712-9kbnyqt3 177 22 75 75 CD cord-325712-9kbnyqt3 177 23 , , , cord-325712-9kbnyqt3 177 24 76 76 CD cord-325712-9kbnyqt3 177 25 ] ] -RRB- cord-325712-9kbnyqt3 177 26 . . . cord-325712-9kbnyqt3 178 1 Coxsackievirus Coxsackievirus NNP cord-325712-9kbnyqt3 178 2 has have VBZ cord-325712-9kbnyqt3 178 3 been be VBN cord-325712-9kbnyqt3 178 4 shown show VBN cord-325712-9kbnyqt3 178 5 to to TO cord-325712-9kbnyqt3 178 6 bind bind VB cord-325712-9kbnyqt3 178 7 on on IN cord-325712-9kbnyqt3 178 8 the the DT cord-325712-9kbnyqt3 178 9 apical apical JJ cord-325712-9kbnyqt3 178 10 surface surface NN cord-325712-9kbnyqt3 178 11 of of IN cord-325712-9kbnyqt3 178 12 epithelia epithelium NNS cord-325712-9kbnyqt3 178 13 , , , cord-325712-9kbnyqt3 178 14 which which WDT cord-325712-9kbnyqt3 178 15 then then RB cord-325712-9kbnyqt3 178 16 triggers trigger VBZ cord-325712-9kbnyqt3 178 17 cytoskeletal cytoskeletal JJ cord-325712-9kbnyqt3 178 18 rearrangement rearrangement NN cord-325712-9kbnyqt3 178 19 that that WDT cord-325712-9kbnyqt3 178 20 transports transport VBZ cord-325712-9kbnyqt3 178 21 the the DT cord-325712-9kbnyqt3 178 22 virus virus NN cord-325712-9kbnyqt3 178 23 to to IN cord-325712-9kbnyqt3 178 24 the the DT cord-325712-9kbnyqt3 178 25 site site NN cord-325712-9kbnyqt3 178 26 of of IN cord-325712-9kbnyqt3 178 27 viral viral JJ cord-325712-9kbnyqt3 178 28 entry entry NN cord-325712-9kbnyqt3 178 29 , , , cord-325712-9kbnyqt3 178 30 the the DT cord-325712-9kbnyqt3 178 31 tight tight JJ cord-325712-9kbnyqt3 178 32 junctions junction NNS cord-325712-9kbnyqt3 178 33 [ [ -LRB- cord-325712-9kbnyqt3 178 34 77 77 CD cord-325712-9kbnyqt3 178 35 ] ] -RRB- cord-325712-9kbnyqt3 178 36 . . . cord-325712-9kbnyqt3 179 1 Finally finally RB cord-325712-9kbnyqt3 179 2 , , , cord-325712-9kbnyqt3 179 3 influenza influenza NN cord-325712-9kbnyqt3 179 4 virus virus NN cord-325712-9kbnyqt3 179 5 appears appear VBZ cord-325712-9kbnyqt3 179 6 to to TO cord-325712-9kbnyqt3 179 7 undergo undergo VB cord-325712-9kbnyqt3 179 8 actindirected actindirecte VBN cord-325712-9kbnyqt3 179 9 motion motion NN cord-325712-9kbnyqt3 179 10 in in IN cord-325712-9kbnyqt3 179 11 the the DT cord-325712-9kbnyqt3 179 12 area area NN cord-325712-9kbnyqt3 179 13 near near IN cord-325712-9kbnyqt3 179 14 its -PRON- PRP$ cord-325712-9kbnyqt3 179 15 initial initial JJ cord-325712-9kbnyqt3 179 16 binding binding NN cord-325712-9kbnyqt3 179 17 site site NN cord-325712-9kbnyqt3 179 18 on on IN cord-325712-9kbnyqt3 179 19 the the DT cord-325712-9kbnyqt3 179 20 cell cell NN cord-325712-9kbnyqt3 179 21 surface surface NN cord-325712-9kbnyqt3 179 22 [ [ -LRB- cord-325712-9kbnyqt3 179 23 10 10 CD cord-325712-9kbnyqt3 179 24 , , , cord-325712-9kbnyqt3 179 25 78 78 CD cord-325712-9kbnyqt3 179 26 ] ] -RRB- cord-325712-9kbnyqt3 179 27 . . . cord-325712-9kbnyqt3 180 1 In in IN cord-325712-9kbnyqt3 180 2 the the DT cord-325712-9kbnyqt3 180 3 in in FW cord-325712-9kbnyqt3 180 4 vitro vitro FW cord-325712-9kbnyqt3 180 5 environment environment NN cord-325712-9kbnyqt3 180 6 of of IN cord-325712-9kbnyqt3 180 7 supported support VBN cord-325712-9kbnyqt3 180 8 lipid lipid NN cord-325712-9kbnyqt3 180 9 bilayer bilayer NN cord-325712-9kbnyqt3 180 10 platforms platform NNS cord-325712-9kbnyqt3 180 11 , , , cord-325712-9kbnyqt3 180 12 virions virion NNS cord-325712-9kbnyqt3 180 13 diffusing diffuse VBG cord-325712-9kbnyqt3 180 14 along along IN cord-325712-9kbnyqt3 180 15 the the DT cord-325712-9kbnyqt3 180 16 bilayer bilayer NN cord-325712-9kbnyqt3 180 17 follow follow VB cord-325712-9kbnyqt3 180 18 a a DT cord-325712-9kbnyqt3 180 19 continuous continuous JJ cord-325712-9kbnyqt3 180 20 trajectory trajectory NN cord-325712-9kbnyqt3 180 21 , , , cord-325712-9kbnyqt3 180 22 whereas whereas IN cord-325712-9kbnyqt3 180 23 those those DT cord-325712-9kbnyqt3 180 24 that that WDT cord-325712-9kbnyqt3 180 25 bind bind VBP cord-325712-9kbnyqt3 180 26 , , , cord-325712-9kbnyqt3 180 27 detach detach VB cord-325712-9kbnyqt3 180 28 , , , cord-325712-9kbnyqt3 180 29 and and CC cord-325712-9kbnyqt3 180 30 rebind rebind VB cord-325712-9kbnyqt3 180 31 elsewhere elsewhere RB cord-325712-9kbnyqt3 180 32 on on IN cord-325712-9kbnyqt3 180 33 the the DT cord-325712-9kbnyqt3 180 34 surface surface NN cord-325712-9kbnyqt3 180 35 " " `` cord-325712-9kbnyqt3 180 36 appear appear VBP cord-325712-9kbnyqt3 180 37 " " '' cord-325712-9kbnyqt3 180 38 and and CC cord-325712-9kbnyqt3 180 39 " " `` cord-325712-9kbnyqt3 180 40 disappear disappear VB cord-325712-9kbnyqt3 180 41 " " '' cord-325712-9kbnyqt3 180 42 under under IN cord-325712-9kbnyqt3 180 43 TIRF tirf NN cord-325712-9kbnyqt3 180 44 microscopy microscopy NNS cord-325712-9kbnyqt3 180 45 . . . cord-325712-9kbnyqt3 181 1 These these DT cord-325712-9kbnyqt3 181 2 modes mode NNS cord-325712-9kbnyqt3 181 3 of of IN cord-325712-9kbnyqt3 181 4 transport transport NN cord-325712-9kbnyqt3 181 5 are be VBP cord-325712-9kbnyqt3 181 6 easily easily RB cord-325712-9kbnyqt3 181 7 distinguished distinguish VBN cord-325712-9kbnyqt3 181 8 from from IN cord-325712-9kbnyqt3 181 9 each each DT cord-325712-9kbnyqt3 181 10 other other JJ cord-325712-9kbnyqt3 181 11 using use VBG cord-325712-9kbnyqt3 181 12 this this DT cord-325712-9kbnyqt3 181 13 microscopy microscopy NN cord-325712-9kbnyqt3 181 14 approach approach NN cord-325712-9kbnyqt3 181 15 [ [ -LRB- cord-325712-9kbnyqt3 181 16 79 79 CD cord-325712-9kbnyqt3 181 17 ] ] -RRB- cord-325712-9kbnyqt3 181 18 . . . cord-325712-9kbnyqt3 182 1 Supported support VBN cord-325712-9kbnyqt3 182 2 lipid lipid NN cord-325712-9kbnyqt3 182 3 bilayers bilayer NNS cord-325712-9kbnyqt3 182 4 have have VBP cord-325712-9kbnyqt3 182 5 an an DT cord-325712-9kbnyqt3 182 6 advantage advantage NN cord-325712-9kbnyqt3 182 7 over over IN cord-325712-9kbnyqt3 182 8 live live JJ cord-325712-9kbnyqt3 182 9 cells cell NNS cord-325712-9kbnyqt3 182 10 for for IN cord-325712-9kbnyqt3 182 11 certain certain JJ cord-325712-9kbnyqt3 182 12 types type NNS cord-325712-9kbnyqt3 182 13 of of IN cord-325712-9kbnyqt3 182 14 studies study NNS cord-325712-9kbnyqt3 182 15 because because IN cord-325712-9kbnyqt3 182 16 of of IN cord-325712-9kbnyqt3 182 17 the the DT cord-325712-9kbnyqt3 182 18 ability ability NN cord-325712-9kbnyqt3 182 19 to to TO cord-325712-9kbnyqt3 182 20 tightly tightly RB cord-325712-9kbnyqt3 182 21 control control VB cord-325712-9kbnyqt3 182 22 composition composition NN cord-325712-9kbnyqt3 182 23 , , , cord-325712-9kbnyqt3 182 24 receptor receptor NN cord-325712-9kbnyqt3 182 25 density density NN cord-325712-9kbnyqt3 182 26 and and CC cord-325712-9kbnyqt3 182 27 mobility mobility NN cord-325712-9kbnyqt3 182 28 , , , cord-325712-9kbnyqt3 182 29 and and CC cord-325712-9kbnyqt3 182 30 surface surface NN cord-325712-9kbnyqt3 182 31 geometry geometry NN cord-325712-9kbnyqt3 182 32 and and CC cord-325712-9kbnyqt3 182 33 heterogeneity heterogeneity NN cord-325712-9kbnyqt3 182 34 . . . cord-325712-9kbnyqt3 183 1 For for IN cord-325712-9kbnyqt3 183 2 example example NN cord-325712-9kbnyqt3 183 3 , , , cord-325712-9kbnyqt3 183 4 supported support VBD cord-325712-9kbnyqt3 183 5 lipid lipid NN cord-325712-9kbnyqt3 183 6 bilayers bilayer NNS cord-325712-9kbnyqt3 183 7 have have VBP cord-325712-9kbnyqt3 183 8 been be VBN cord-325712-9kbnyqt3 183 9 used use VBN cord-325712-9kbnyqt3 183 10 to to TO cord-325712-9kbnyqt3 183 11 observe observe VB cord-325712-9kbnyqt3 183 12 sliding slide VBG cord-325712-9kbnyqt3 183 13 and and CC cord-325712-9kbnyqt3 183 14 tumbling tumble VBG cord-325712-9kbnyqt3 183 15 of of IN cord-325712-9kbnyqt3 183 16 quantum quantum NN cord-325712-9kbnyqt3 183 17 dot dot NN cord-325712-9kbnyqt3 183 18 - - HYPH cord-325712-9kbnyqt3 183 19 labeled label VBN cord-325712-9kbnyqt3 183 20 simian simian JJ cord-325712-9kbnyqt3 183 21 virus virus NN cord-325712-9kbnyqt3 183 22 40 40 CD cord-325712-9kbnyqt3 183 23 virus virus NN cord-325712-9kbnyqt3 183 24 - - HYPH cord-325712-9kbnyqt3 183 25 like like JJ cord-325712-9kbnyqt3 183 26 particles particle NNS cord-325712-9kbnyqt3 183 27 on on IN cord-325712-9kbnyqt3 183 28 bilayers bilayer NNS cord-325712-9kbnyqt3 183 29 containing contain VBG cord-325712-9kbnyqt3 183 30 low low JJ cord-325712-9kbnyqt3 183 31 concentrations concentration NNS cord-325712-9kbnyqt3 183 32 of of IN cord-325712-9kbnyqt3 183 33 GM1 GM1 NNP cord-325712-9kbnyqt3 183 34 and and CC cord-325712-9kbnyqt3 183 35 back back NN cord-325712-9kbnyqt3 183 36 - - HYPH cord-325712-9kbnyqt3 183 37 and and CC cord-325712-9kbnyqt3 183 38 - - HYPH cord-325712-9kbnyqt3 183 39 forth forth RB cord-325712-9kbnyqt3 183 40 rocking rock VBG cord-325712-9kbnyqt3 183 41 at at IN cord-325712-9kbnyqt3 183 42 high high JJ cord-325712-9kbnyqt3 183 43 receptor receptor NN cord-325712-9kbnyqt3 183 44 concentrations concentration NNS cord-325712-9kbnyqt3 183 45 [ [ -LRB- cord-325712-9kbnyqt3 183 46 36 36 CD cord-325712-9kbnyqt3 183 47 ] ] -RRB- cord-325712-9kbnyqt3 183 48 . . . cord-325712-9kbnyqt3 184 1 However however RB cord-325712-9kbnyqt3 184 2 , , , cord-325712-9kbnyqt3 184 3 because because IN cord-325712-9kbnyqt3 184 4 lipid lipid NN cord-325712-9kbnyqt3 184 5 bilayers bilayer NNS cord-325712-9kbnyqt3 184 6 do do VBP cord-325712-9kbnyqt3 184 7 not not RB cord-325712-9kbnyqt3 184 8 contain contain VB cord-325712-9kbnyqt3 184 9 the the DT cord-325712-9kbnyqt3 184 10 full full JJ cord-325712-9kbnyqt3 184 11 cytoskeletal cytoskeletal JJ cord-325712-9kbnyqt3 184 12 network network NN cord-325712-9kbnyqt3 184 13 of of IN cord-325712-9kbnyqt3 184 14 cells cell NNS cord-325712-9kbnyqt3 184 15 , , , cord-325712-9kbnyqt3 184 16 it -PRON- PRP cord-325712-9kbnyqt3 184 17 is be VBZ cord-325712-9kbnyqt3 184 18 possible possible JJ cord-325712-9kbnyqt3 184 19 that that IN cord-325712-9kbnyqt3 184 20 virion virion NN cord-325712-9kbnyqt3 184 21 motion motion NN cord-325712-9kbnyqt3 184 22 in in IN cord-325712-9kbnyqt3 184 23 these these DT cord-325712-9kbnyqt3 184 24 platforms platform NNS cord-325712-9kbnyqt3 184 25 could could MD cord-325712-9kbnyqt3 184 26 be be VB cord-325712-9kbnyqt3 184 27 different different JJ cord-325712-9kbnyqt3 184 28 from from IN cord-325712-9kbnyqt3 184 29 their -PRON- PRP$ cord-325712-9kbnyqt3 184 30 motion motion NN cord-325712-9kbnyqt3 184 31 in in IN cord-325712-9kbnyqt3 184 32 vivo vivo NNP cord-325712-9kbnyqt3 184 33 . . . cord-325712-9kbnyqt3 185 1 Studies study NNS cord-325712-9kbnyqt3 185 2 of of IN cord-325712-9kbnyqt3 185 3 virus virus NN cord-325712-9kbnyqt3 185 4 binding bind VBG cord-325712-9kbnyqt3 185 5 kinetics kinetics NN cord-325712-9kbnyqt3 185 6 and and CC cord-325712-9kbnyqt3 185 7 determination determination NN cord-325712-9kbnyqt3 185 8 of of IN cord-325712-9kbnyqt3 185 9 binding bind VBG cord-325712-9kbnyqt3 185 10 strength strength NN cord-325712-9kbnyqt3 185 11 are be VBP cord-325712-9kbnyqt3 185 12 often often RB cord-325712-9kbnyqt3 185 13 carried carry VBN cord-325712-9kbnyqt3 185 14 out out RP cord-325712-9kbnyqt3 185 15 in in RB cord-325712-9kbnyqt3 185 16 in in FW cord-325712-9kbnyqt3 185 17 vitro vitro FW cord-325712-9kbnyqt3 185 18 assays assay NNS cord-325712-9kbnyqt3 185 19 , , , cord-325712-9kbnyqt3 185 20 either either CC cord-325712-9kbnyqt3 185 21 by by IN cord-325712-9kbnyqt3 185 22 monitoring monitor VBG cord-325712-9kbnyqt3 185 23 many many JJ cord-325712-9kbnyqt3 185 24 single single JJ cord-325712-9kbnyqt3 185 25 virion virion NN cord-325712-9kbnyqt3 185 26 events event NNS cord-325712-9kbnyqt3 185 27 or or CC cord-325712-9kbnyqt3 185 28 following follow VBG cord-325712-9kbnyqt3 185 29 ensemble ensemble JJ cord-325712-9kbnyqt3 185 30 behavior behavior NN cord-325712-9kbnyqt3 185 31 of of IN cord-325712-9kbnyqt3 185 32 a a DT cord-325712-9kbnyqt3 185 33 population population NN cord-325712-9kbnyqt3 185 34 . . . cord-325712-9kbnyqt3 186 1 In in IN cord-325712-9kbnyqt3 186 2 this this DT cord-325712-9kbnyqt3 186 3 section section NN cord-325712-9kbnyqt3 186 4 , , , cord-325712-9kbnyqt3 186 5 we -PRON- PRP cord-325712-9kbnyqt3 186 6 describe describe VBP cord-325712-9kbnyqt3 186 7 these these DT cord-325712-9kbnyqt3 186 8 approaches approach NNS cord-325712-9kbnyqt3 186 9 and and CC cord-325712-9kbnyqt3 186 10 highlight highlight VB cord-325712-9kbnyqt3 186 11 some some DT cord-325712-9kbnyqt3 186 12 selected select VBN cord-325712-9kbnyqt3 186 13 studies study NNS cord-325712-9kbnyqt3 186 14 that that WDT cord-325712-9kbnyqt3 186 15 illustrate illustrate VBP cord-325712-9kbnyqt3 186 16 their -PRON- PRP$ cord-325712-9kbnyqt3 186 17 utility utility NN cord-325712-9kbnyqt3 186 18 . . . cord-325712-9kbnyqt3 187 1 Direct direct JJ cord-325712-9kbnyqt3 187 2 observation observation NN cord-325712-9kbnyqt3 187 3 of of IN cord-325712-9kbnyqt3 187 4 many many JJ cord-325712-9kbnyqt3 187 5 individual individual JJ cord-325712-9kbnyqt3 187 6 virion virion NN cord-325712-9kbnyqt3 187 7 interactions interaction NNS cord-325712-9kbnyqt3 187 8 with with IN cord-325712-9kbnyqt3 187 9 supported support VBN cord-325712-9kbnyqt3 187 10 lipid lipid NN cord-325712-9kbnyqt3 187 11 bilayers bilayer NNS cord-325712-9kbnyqt3 187 12 can can MD cord-325712-9kbnyqt3 187 13 be be VB cord-325712-9kbnyqt3 187 14 used use VBN cord-325712-9kbnyqt3 187 15 to to TO cord-325712-9kbnyqt3 187 16 measure measure VB cord-325712-9kbnyqt3 187 17 receptor receptor NN cord-325712-9kbnyqt3 187 18 binding binding NN cord-325712-9kbnyqt3 187 19 and and CC cord-325712-9kbnyqt3 187 20 detachment detachment NN cord-325712-9kbnyqt3 187 21 rates rate NNS cord-325712-9kbnyqt3 187 22 , , , cord-325712-9kbnyqt3 187 23 multivalent multivalent JJ cord-325712-9kbnyqt3 187 24 avidity avidity NN cord-325712-9kbnyqt3 187 25 characteristics characteristic NNS cord-325712-9kbnyqt3 187 26 , , , cord-325712-9kbnyqt3 187 27 and and CC cord-325712-9kbnyqt3 187 28 equilibrium equilibrium NN cord-325712-9kbnyqt3 187 29 binding bind VBG cord-325712-9kbnyqt3 187 30 constants constant NNS cord-325712-9kbnyqt3 187 31 . . . cord-325712-9kbnyqt3 188 1 TIRF TIRF NNP cord-325712-9kbnyqt3 188 2 microscopy microscopy NN cord-325712-9kbnyqt3 188 3 is be VBZ cord-325712-9kbnyqt3 188 4 the the DT cord-325712-9kbnyqt3 188 5 most most RBS cord-325712-9kbnyqt3 188 6 common common JJ cord-325712-9kbnyqt3 188 7 method method NN cord-325712-9kbnyqt3 188 8 used use VBN cord-325712-9kbnyqt3 188 9 in in IN cord-325712-9kbnyqt3 188 10 monitoring monitor VBG cord-325712-9kbnyqt3 188 11 individual individual JJ cord-325712-9kbnyqt3 188 12 virions virion NNS cord-325712-9kbnyqt3 188 13 binding bind VBG cord-325712-9kbnyqt3 188 14 to to IN cord-325712-9kbnyqt3 188 15 biomimetic biomimetic JJ cord-325712-9kbnyqt3 188 16 membranes membrane NNS cord-325712-9kbnyqt3 188 17 because because IN cord-325712-9kbnyqt3 188 18 it -PRON- PRP cord-325712-9kbnyqt3 188 19 clearly clearly RB cord-325712-9kbnyqt3 188 20 distinguishes distinguish VBZ cord-325712-9kbnyqt3 188 21 labeled label VBN cord-325712-9kbnyqt3 188 22 virions virion NNS cord-325712-9kbnyqt3 188 23 that that WDT cord-325712-9kbnyqt3 188 24 are be VBP cord-325712-9kbnyqt3 188 25 bound bind VBN cord-325712-9kbnyqt3 188 26 to to IN cord-325712-9kbnyqt3 188 27 the the DT cord-325712-9kbnyqt3 188 28 lipid lipid NN cord-325712-9kbnyqt3 188 29 bilayer bilayer NN cord-325712-9kbnyqt3 188 30 from from IN cord-325712-9kbnyqt3 188 31 unbound unbound JJ cord-325712-9kbnyqt3 188 32 virions virion NNS cord-325712-9kbnyqt3 188 33 in in IN cord-325712-9kbnyqt3 188 34 the the DT cord-325712-9kbnyqt3 188 35 bulk bulk JJ cord-325712-9kbnyqt3 188 36 solution solution NN cord-325712-9kbnyqt3 188 37 ( ( -LRB- cord-325712-9kbnyqt3 188 38 Fig fig NN cord-325712-9kbnyqt3 188 39 . . . cord-325712-9kbnyqt3 188 40 2.5 2.5 CD cord-325712-9kbnyqt3 188 41 ) ) -RRB- cord-325712-9kbnyqt3 188 42 . . . cord-325712-9kbnyqt3 189 1 In in IN cord-325712-9kbnyqt3 189 2 this this DT cord-325712-9kbnyqt3 189 3 experimental experimental JJ cord-325712-9kbnyqt3 189 4 approach approach NN cord-325712-9kbnyqt3 189 5 , , , cord-325712-9kbnyqt3 189 6 the the DT cord-325712-9kbnyqt3 189 7 residence residence NN cord-325712-9kbnyqt3 189 8 time time NN cord-325712-9kbnyqt3 189 9 of of IN cord-325712-9kbnyqt3 189 10 bound bind VBN cord-325712-9kbnyqt3 189 11 virions virion NNS cord-325712-9kbnyqt3 189 12 can can MD cord-325712-9kbnyqt3 189 13 be be VB cord-325712-9kbnyqt3 189 14 collected collect VBN cord-325712-9kbnyqt3 189 15 for for IN cord-325712-9kbnyqt3 189 16 each each DT cord-325712-9kbnyqt3 189 17 individual individual JJ cord-325712-9kbnyqt3 189 18 Residence Residence NNP cord-325712-9kbnyqt3 189 19 times time NNS cord-325712-9kbnyqt3 189 20 can can MD cord-325712-9kbnyqt3 189 21 be be VB cord-325712-9kbnyqt3 189 22 determined determine VBN cord-325712-9kbnyqt3 189 23 by by IN cord-325712-9kbnyqt3 189 24 the the DT cord-325712-9kbnyqt3 189 25 number number NN cord-325712-9kbnyqt3 189 26 of of IN cord-325712-9kbnyqt3 189 27 frames frame NNS cord-325712-9kbnyqt3 189 28 the the DT cord-325712-9kbnyqt3 189 29 virion virion NN cord-325712-9kbnyqt3 189 30 remains remain VBZ cord-325712-9kbnyqt3 189 31 observable observable JJ cord-325712-9kbnyqt3 189 32 , , , cord-325712-9kbnyqt3 189 33 as as IN cord-325712-9kbnyqt3 189 34 shown show VBN cord-325712-9kbnyqt3 189 35 in in IN cord-325712-9kbnyqt3 189 36 the the DT cord-325712-9kbnyqt3 189 37 images image NNS cord-325712-9kbnyqt3 189 38 below below IN cord-325712-9kbnyqt3 189 39 the the DT cord-325712-9kbnyqt3 189 40 cartoons cartoon NNS cord-325712-9kbnyqt3 189 41 , , , cord-325712-9kbnyqt3 189 42 before before IN cord-325712-9kbnyqt3 189 43 the the DT cord-325712-9kbnyqt3 189 44 virion virion NN cord-325712-9kbnyqt3 189 45 unbinds unbind VBZ cord-325712-9kbnyqt3 189 46 virion virion NN cord-325712-9kbnyqt3 189 47 . . . cord-325712-9kbnyqt3 190 1 As as IN cord-325712-9kbnyqt3 190 2 experimental experimental JJ cord-325712-9kbnyqt3 190 3 conditions condition NNS cord-325712-9kbnyqt3 190 4 change change NN cord-325712-9kbnyqt3 190 5 , , , cord-325712-9kbnyqt3 190 6 shifts shift NNS cord-325712-9kbnyqt3 190 7 in in IN cord-325712-9kbnyqt3 190 8 residence residence NN cord-325712-9kbnyqt3 190 9 times time NNS cord-325712-9kbnyqt3 190 10 can can MD cord-325712-9kbnyqt3 190 11 be be VB cord-325712-9kbnyqt3 190 12 monitored monitor VBN cord-325712-9kbnyqt3 190 13 . . . cord-325712-9kbnyqt3 191 1 From from IN cord-325712-9kbnyqt3 191 2 this this DT cord-325712-9kbnyqt3 191 3 data data NN cord-325712-9kbnyqt3 191 4 , , , cord-325712-9kbnyqt3 191 5 binding bind VBG cord-325712-9kbnyqt3 191 6 characteristics characteristic NNS cord-325712-9kbnyqt3 191 7 can can MD cord-325712-9kbnyqt3 191 8 be be VB cord-325712-9kbnyqt3 191 9 quantified quantify VBN cord-325712-9kbnyqt3 191 10 . . . cord-325712-9kbnyqt3 192 1 Initial initial JJ cord-325712-9kbnyqt3 192 2 work work NN cord-325712-9kbnyqt3 192 3 monitoring monitor VBG cord-325712-9kbnyqt3 192 4 nanoparticle nanoparticle NN cord-325712-9kbnyqt3 192 5 binding bind VBG cord-325712-9kbnyqt3 192 6 to to IN cord-325712-9kbnyqt3 192 7 supported support VBN cord-325712-9kbnyqt3 192 8 bilayers bilayer NNS cord-325712-9kbnyqt3 192 9 and and CC cord-325712-9kbnyqt3 192 10 surfacetethered surfacetethere VBN cord-325712-9kbnyqt3 192 11 vesicles vesicle NNS cord-325712-9kbnyqt3 192 12 demonstrated demonstrate VBD cord-325712-9kbnyqt3 192 13 the the DT cord-325712-9kbnyqt3 192 14 advantage advantage NN cord-325712-9kbnyqt3 192 15 of of IN cord-325712-9kbnyqt3 192 16 using use VBG cord-325712-9kbnyqt3 192 17 TIRF TIRF NNP cord-325712-9kbnyqt3 192 18 microscopy microscopy NNS cord-325712-9kbnyqt3 192 19 in in IN cord-325712-9kbnyqt3 192 20 this this DT cord-325712-9kbnyqt3 192 21 application application NN cord-325712-9kbnyqt3 192 22 . . . cord-325712-9kbnyqt3 193 1 Here here RB cord-325712-9kbnyqt3 193 2 , , , cord-325712-9kbnyqt3 193 3 a a DT cord-325712-9kbnyqt3 193 4 useful useful JJ cord-325712-9kbnyqt3 193 5 approach approach NN cord-325712-9kbnyqt3 193 6 , , , cord-325712-9kbnyqt3 193 7 equilibrium equilibrium NN cord-325712-9kbnyqt3 193 8 - - HYPH cord-325712-9kbnyqt3 193 9 fluctuation fluctuation NN cord-325712-9kbnyqt3 193 10 - - HYPH cord-325712-9kbnyqt3 193 11 analysis analysis NN cord-325712-9kbnyqt3 193 12 , , , cord-325712-9kbnyqt3 193 13 was be VBD cord-325712-9kbnyqt3 193 14 developed develop VBN cord-325712-9kbnyqt3 193 15 to to TO cord-325712-9kbnyqt3 193 16 quantify quantify VB cord-325712-9kbnyqt3 193 17 apparent apparent JJ cord-325712-9kbnyqt3 193 18 kinetic kinetic JJ cord-325712-9kbnyqt3 193 19 rate rate NN cord-325712-9kbnyqt3 193 20 constants constant NNS cord-325712-9kbnyqt3 193 21 of of IN cord-325712-9kbnyqt3 193 22 carbohydrate carbohydrate NN cord-325712-9kbnyqt3 193 23 - - HYPH cord-325712-9kbnyqt3 193 24 bearing bear VBG cord-325712-9kbnyqt3 193 25 particles particle NNS cord-325712-9kbnyqt3 193 26 with with IN cord-325712-9kbnyqt3 193 27 carbohydrate carbohydrate NN cord-325712-9kbnyqt3 193 28 presenting present VBG cord-325712-9kbnyqt3 193 29 SLBs slbs NN cord-325712-9kbnyqt3 193 30 [ [ -LRB- cord-325712-9kbnyqt3 193 31 80 80 CD cord-325712-9kbnyqt3 193 32 ] ] -RRB- cord-325712-9kbnyqt3 193 33 . . . cord-325712-9kbnyqt3 194 1 This this DT cord-325712-9kbnyqt3 194 2 analysis analysis NN cord-325712-9kbnyqt3 194 3 was be VBD cord-325712-9kbnyqt3 194 4 then then RB cord-325712-9kbnyqt3 194 5 extended extend VBN cord-325712-9kbnyqt3 194 6 to to IN cord-325712-9kbnyqt3 194 7 studies study NNS cord-325712-9kbnyqt3 194 8 of of IN cord-325712-9kbnyqt3 194 9 virus virus NN cord-325712-9kbnyqt3 194 10 - - HYPH cord-325712-9kbnyqt3 194 11 like like JJ cord-325712-9kbnyqt3 194 12 particles particle NNS cord-325712-9kbnyqt3 194 13 [ [ -LRB- cord-325712-9kbnyqt3 194 14 49 49 CD cord-325712-9kbnyqt3 194 15 , , , cord-325712-9kbnyqt3 194 16 81 81 CD cord-325712-9kbnyqt3 194 17 ] ] -RRB- cord-325712-9kbnyqt3 194 18 and and CC cord-325712-9kbnyqt3 194 19 live live JJ cord-325712-9kbnyqt3 194 20 virions virion NNS cord-325712-9kbnyqt3 194 21 [ [ -LRB- cord-325712-9kbnyqt3 194 22 81 81 CD cord-325712-9kbnyqt3 194 23 ] ] -RRB- cord-325712-9kbnyqt3 194 24 interacting interact VBG cord-325712-9kbnyqt3 194 25 with with IN cord-325712-9kbnyqt3 194 26 glycosylated glycosylated JJ cord-325712-9kbnyqt3 194 27 bilayers bilayer NNS cord-325712-9kbnyqt3 194 28 to to TO cord-325712-9kbnyqt3 194 29 provide provide VB cord-325712-9kbnyqt3 194 30 new new JJ cord-325712-9kbnyqt3 194 31 insight insight NN cord-325712-9kbnyqt3 194 32 into into IN cord-325712-9kbnyqt3 194 33 virus virus NN cord-325712-9kbnyqt3 194 34 attachment attachment NN cord-325712-9kbnyqt3 194 35 to to IN cord-325712-9kbnyqt3 194 36 cell cell NN cord-325712-9kbnyqt3 194 37 surfaces surface NNS cord-325712-9kbnyqt3 194 38 and and CC cord-325712-9kbnyqt3 194 39 applications application NNS cord-325712-9kbnyqt3 194 40 in in IN cord-325712-9kbnyqt3 194 41 biosensing biosense VBG cord-325712-9kbnyqt3 194 42 [ [ -LRB- cord-325712-9kbnyqt3 194 43 82 82 CD cord-325712-9kbnyqt3 194 44 ] ] -RRB- cord-325712-9kbnyqt3 194 45 . . . cord-325712-9kbnyqt3 195 1 The the DT cord-325712-9kbnyqt3 195 2 kinetics kinetic NNS cord-325712-9kbnyqt3 195 3 of of IN cord-325712-9kbnyqt3 195 4 particle particle NN cord-325712-9kbnyqt3 195 5 detachment detachment NN cord-325712-9kbnyqt3 195 6 [ [ -LRB- cord-325712-9kbnyqt3 195 7 83 83 CD cord-325712-9kbnyqt3 195 8 ] ] -RRB- cord-325712-9kbnyqt3 195 9 can can MD cord-325712-9kbnyqt3 195 10 also also RB cord-325712-9kbnyqt3 195 11 be be VB cord-325712-9kbnyqt3 195 12 studied study VBN cord-325712-9kbnyqt3 195 13 in in IN cord-325712-9kbnyqt3 195 14 these these DT cord-325712-9kbnyqt3 195 15 platforms platform NNS cord-325712-9kbnyqt3 195 16 , , , cord-325712-9kbnyqt3 195 17 as as IN cord-325712-9kbnyqt3 195 18 can can MD cord-325712-9kbnyqt3 195 19 multivalent multivalent JJ cord-325712-9kbnyqt3 195 20 binding bind VBG cord-325712-9kbnyqt3 195 21 behavior behavior NN cord-325712-9kbnyqt3 195 22 [ [ -LRB- cord-325712-9kbnyqt3 195 23 62 62 CD cord-325712-9kbnyqt3 195 24 , , , cord-325712-9kbnyqt3 195 25 84 84 CD cord-325712-9kbnyqt3 195 26 ] ] -RRB- cord-325712-9kbnyqt3 195 27 . . . cord-325712-9kbnyqt3 196 1 Such such JJ cord-325712-9kbnyqt3 196 2 studies study NNS cord-325712-9kbnyqt3 196 3 can can MD cord-325712-9kbnyqt3 196 4 reveal reveal VB cord-325712-9kbnyqt3 196 5 changes change NNS cord-325712-9kbnyqt3 196 6 in in IN cord-325712-9kbnyqt3 196 7 binding bind VBG cord-325712-9kbnyqt3 196 8 behavior behavior NN cord-325712-9kbnyqt3 196 9 that that WDT cord-325712-9kbnyqt3 196 10 promote promote VBP cord-325712-9kbnyqt3 196 11 viral viral JJ cord-325712-9kbnyqt3 196 12 attachment attachment NN cord-325712-9kbnyqt3 196 13 . . . cord-325712-9kbnyqt3 197 1 For for IN cord-325712-9kbnyqt3 197 2 example example NN cord-325712-9kbnyqt3 197 3 , , , cord-325712-9kbnyqt3 197 4 both both DT cord-325712-9kbnyqt3 197 5 influenza influenza NN cord-325712-9kbnyqt3 197 6 and and CC cord-325712-9kbnyqt3 197 7 canine canine JJ cord-325712-9kbnyqt3 197 8 parvovirus parvovirus NN cord-325712-9kbnyqt3 197 9 undergo undergo VBP cord-325712-9kbnyqt3 197 10 " " `` cord-325712-9kbnyqt3 197 11 adhesion adhesion NN cord-325712-9kbnyqt3 197 12 - - HYPH cord-325712-9kbnyqt3 197 13 strengthening strengthen VBG cord-325712-9kbnyqt3 197 14 " " '' cord-325712-9kbnyqt3 197 15 where where WRB cord-325712-9kbnyqt3 197 16 the the DT cord-325712-9kbnyqt3 197 17 longer long RBR cord-325712-9kbnyqt3 197 18 a a DT cord-325712-9kbnyqt3 197 19 virion virion NN cord-325712-9kbnyqt3 197 20 is be VBZ cord-325712-9kbnyqt3 197 21 bound bind VBN cord-325712-9kbnyqt3 197 22 , , , cord-325712-9kbnyqt3 197 23 the the DT cord-325712-9kbnyqt3 197 24 more more RBR cord-325712-9kbnyqt3 197 25 strongly strongly RB cord-325712-9kbnyqt3 197 26 it -PRON- PRP cord-325712-9kbnyqt3 197 27 adheres adhere VBZ cord-325712-9kbnyqt3 197 28 to to IN cord-325712-9kbnyqt3 197 29 the the DT cord-325712-9kbnyqt3 197 30 bilayer bilayer NN cord-325712-9kbnyqt3 197 31 [ [ -LRB- cord-325712-9kbnyqt3 197 32 37 37 CD cord-325712-9kbnyqt3 197 33 , , , cord-325712-9kbnyqt3 197 34 85 85 CD cord-325712-9kbnyqt3 197 35 ] ] -RRB- cord-325712-9kbnyqt3 197 36 . . . cord-325712-9kbnyqt3 198 1 Overall overall RB cord-325712-9kbnyqt3 198 2 , , , cord-325712-9kbnyqt3 198 3 these these DT cord-325712-9kbnyqt3 198 4 platforms platform NNS cord-325712-9kbnyqt3 198 5 are be VBP cord-325712-9kbnyqt3 198 6 convenient convenient JJ cord-325712-9kbnyqt3 198 7 for for IN cord-325712-9kbnyqt3 198 8 gathering gather VBG cord-325712-9kbnyqt3 198 9 insight insight NN cord-325712-9kbnyqt3 198 10 on on IN cord-325712-9kbnyqt3 198 11 this this DT cord-325712-9kbnyqt3 198 12 critical critical JJ cord-325712-9kbnyqt3 198 13 virus virus NN cord-325712-9kbnyqt3 198 14 entry entry NN cord-325712-9kbnyqt3 198 15 step step NN cord-325712-9kbnyqt3 198 16 and and CC cord-325712-9kbnyqt3 198 17 how how WRB cord-325712-9kbnyqt3 198 18 it -PRON- PRP cord-325712-9kbnyqt3 198 19 depends depend VBZ cord-325712-9kbnyqt3 198 20 on on IN cord-325712-9kbnyqt3 198 21 the the DT cord-325712-9kbnyqt3 198 22 host host NN cord-325712-9kbnyqt3 198 23 cell cell NN cord-325712-9kbnyqt3 198 24 surface surface NN cord-325712-9kbnyqt3 198 25 . . . cord-325712-9kbnyqt3 199 1 One one CD cord-325712-9kbnyqt3 199 2 advantage advantage NN cord-325712-9kbnyqt3 199 3 of of IN cord-325712-9kbnyqt3 199 4 this this DT cord-325712-9kbnyqt3 199 5 platform platform NN cord-325712-9kbnyqt3 199 6 is be VBZ cord-325712-9kbnyqt3 199 7 the the DT cord-325712-9kbnyqt3 199 8 tunability tunability NN cord-325712-9kbnyqt3 199 9 of of IN cord-325712-9kbnyqt3 199 10 the the DT cord-325712-9kbnyqt3 199 11 bilayer bilayer NN cord-325712-9kbnyqt3 199 12 compositions composition NNS cord-325712-9kbnyqt3 199 13 and and CC cord-325712-9kbnyqt3 199 14 heterogeneity heterogeneity NN cord-325712-9kbnyqt3 199 15 . . . cord-325712-9kbnyqt3 200 1 For for IN cord-325712-9kbnyqt3 200 2 example example NN cord-325712-9kbnyqt3 200 3 , , , cord-325712-9kbnyqt3 200 4 single single JJ cord-325712-9kbnyqt3 200 5 particle particle NN cord-325712-9kbnyqt3 200 6 binding binding NN cord-325712-9kbnyqt3 200 7 studies study NNS cord-325712-9kbnyqt3 200 8 have have VBP cord-325712-9kbnyqt3 200 9 revealed reveal VBN cord-325712-9kbnyqt3 200 10 the the DT cord-325712-9kbnyqt3 200 11 importance importance NN cord-325712-9kbnyqt3 200 12 of of IN cord-325712-9kbnyqt3 200 13 microdomains microdomain NNS cord-325712-9kbnyqt3 200 14 in in IN cord-325712-9kbnyqt3 200 15 binding binding NN cord-325712-9kbnyqt3 200 16 of of IN cord-325712-9kbnyqt3 200 17 norovirus norovirus NN cord-325712-9kbnyqt3 200 18 - - HYPH cord-325712-9kbnyqt3 200 19 like like JJ cord-325712-9kbnyqt3 200 20 particles particle NNS cord-325712-9kbnyqt3 200 21 , , , cord-325712-9kbnyqt3 200 22 which which WDT cord-325712-9kbnyqt3 200 23 preferentially preferentially RB cord-325712-9kbnyqt3 200 24 bind bind VBP cord-325712-9kbnyqt3 200 25 the the DT cord-325712-9kbnyqt3 200 26 edges edge NNS cord-325712-9kbnyqt3 200 27 of of IN cord-325712-9kbnyqt3 200 28 glycosphingolipid glycosphingolipid NN cord-325712-9kbnyqt3 200 29 - - HYPH cord-325712-9kbnyqt3 200 30 enriched enrich VBN cord-325712-9kbnyqt3 200 31 domains domain NNS cord-325712-9kbnyqt3 200 32 [ [ -LRB- cord-325712-9kbnyqt3 200 33 49 49 CD cord-325712-9kbnyqt3 200 34 ] ] -RRB- cord-325712-9kbnyqt3 200 35 . . . cord-325712-9kbnyqt3 201 1 Later later RB cord-325712-9kbnyqt3 201 2 it -PRON- PRP cord-325712-9kbnyqt3 201 3 was be VBD cord-325712-9kbnyqt3 201 4 also also RB cord-325712-9kbnyqt3 201 5 shown show VBN cord-325712-9kbnyqt3 201 6 that that IN cord-325712-9kbnyqt3 201 7 HIV HIV NNP cord-325712-9kbnyqt3 201 8 particles particle NNS cord-325712-9kbnyqt3 201 9 prefer prefer VBP cord-325712-9kbnyqt3 201 10 to to TO cord-325712-9kbnyqt3 201 11 bind bind VB cord-325712-9kbnyqt3 201 12 at at IN cord-325712-9kbnyqt3 201 13 the the DT cord-325712-9kbnyqt3 201 14 edges edge NNS cord-325712-9kbnyqt3 201 15 of of IN cord-325712-9kbnyqt3 201 16 cholesterol cholesterol NN cord-325712-9kbnyqt3 201 17 - - HYPH cord-325712-9kbnyqt3 201 18 rich rich JJ cord-325712-9kbnyqt3 201 19 lipid lipid NN cord-325712-9kbnyqt3 201 20 domains domain NNS cord-325712-9kbnyqt3 201 21 that that WDT cord-325712-9kbnyqt3 201 22 were be VBD cord-325712-9kbnyqt3 201 23 reconstituted reconstitute VBN cord-325712-9kbnyqt3 201 24 in in IN cord-325712-9kbnyqt3 201 25 supported support VBN cord-325712-9kbnyqt3 201 26 bilayers bilayer NNS cord-325712-9kbnyqt3 201 27 [ [ -LRB- cord-325712-9kbnyqt3 201 28 86 86 CD cord-325712-9kbnyqt3 201 29 , , , cord-325712-9kbnyqt3 201 30 87 87 CD cord-325712-9kbnyqt3 201 31 ] ] -RRB- cord-325712-9kbnyqt3 201 32 ; ; : cord-325712-9kbnyqt3 201 33 however however RB cord-325712-9kbnyqt3 201 34 , , , cord-325712-9kbnyqt3 201 35 observing observe VBG cord-325712-9kbnyqt3 201 36 this this DT cord-325712-9kbnyqt3 201 37 preference preference NN cord-325712-9kbnyqt3 201 38 in in IN cord-325712-9kbnyqt3 201 39 live live JJ cord-325712-9kbnyqt3 201 40 cells cell NNS cord-325712-9kbnyqt3 201 41 due due IN cord-325712-9kbnyqt3 201 42 to to IN cord-325712-9kbnyqt3 201 43 the the DT cord-325712-9kbnyqt3 201 44 small small JJ cord-325712-9kbnyqt3 201 45 scale scale NN cord-325712-9kbnyqt3 201 46 and and CC cord-325712-9kbnyqt3 201 47 dynamism dynamism NN cord-325712-9kbnyqt3 201 48 of of IN cord-325712-9kbnyqt3 201 49 lipid lipid NN cord-325712-9kbnyqt3 201 50 rafts raft NNS cord-325712-9kbnyqt3 201 51 is be VBZ cord-325712-9kbnyqt3 201 52 difficult difficult JJ cord-325712-9kbnyqt3 201 53 , , , cord-325712-9kbnyqt3 201 54 illustrating illustrate VBG cord-325712-9kbnyqt3 201 55 the the DT cord-325712-9kbnyqt3 201 56 power power NN cord-325712-9kbnyqt3 201 57 of of IN cord-325712-9kbnyqt3 201 58 using use VBG cord-325712-9kbnyqt3 201 59 an an DT cord-325712-9kbnyqt3 201 60 in in FW cord-325712-9kbnyqt3 201 61 vitro vitro FW cord-325712-9kbnyqt3 201 62 system system NN cord-325712-9kbnyqt3 201 63 for for IN cord-325712-9kbnyqt3 201 64 such such JJ cord-325712-9kbnyqt3 201 65 studies study NNS cord-325712-9kbnyqt3 201 66 . . . cord-325712-9kbnyqt3 202 1 Focusing focus VBG cord-325712-9kbnyqt3 202 2 further far RBR cord-325712-9kbnyqt3 202 3 on on IN cord-325712-9kbnyqt3 202 4 the the DT cord-325712-9kbnyqt3 202 5 receptors receptor NNS cord-325712-9kbnyqt3 202 6 themselves -PRON- PRP cord-325712-9kbnyqt3 202 7 , , , cord-325712-9kbnyqt3 202 8 TIRF tirf NN cord-325712-9kbnyqt3 202 9 microscopy microscopy NN cord-325712-9kbnyqt3 202 10 has have VBZ cord-325712-9kbnyqt3 202 11 also also RB cord-325712-9kbnyqt3 202 12 been be VBN cord-325712-9kbnyqt3 202 13 used use VBN cord-325712-9kbnyqt3 202 14 to to TO cord-325712-9kbnyqt3 202 15 measure measure VB cord-325712-9kbnyqt3 202 16 the the DT cord-325712-9kbnyqt3 202 17 affinity affinity NN cord-325712-9kbnyqt3 202 18 of of IN cord-325712-9kbnyqt3 202 19 HIV HIV NNP cord-325712-9kbnyqt3 202 20 glycoprotein glycoprotein NN cord-325712-9kbnyqt3 202 21 120 120 CD cord-325712-9kbnyqt3 202 22 for for IN cord-325712-9kbnyqt3 202 23 the the DT cord-325712-9kbnyqt3 202 24 glycosphingolipids glycosphingolipid NNS cord-325712-9kbnyqt3 202 25 galactosyl galactosyl NNP cord-325712-9kbnyqt3 202 26 ceramide ceramide NN cord-325712-9kbnyqt3 202 27 , , , cord-325712-9kbnyqt3 202 28 glucosylceramide glucosylceramide NNP cord-325712-9kbnyqt3 202 29 , , , cord-325712-9kbnyqt3 202 30 lactosylceramide lactosylceramide NN cord-325712-9kbnyqt3 202 31 and and CC cord-325712-9kbnyqt3 202 32 α α NN cord-325712-9kbnyqt3 202 33 - - HYPH cord-325712-9kbnyqt3 202 34 hydroxy hydroxy JJ cord-325712-9kbnyqt3 202 35 glucosylceramide glucosylceramide NN cord-325712-9kbnyqt3 202 36 in in IN cord-325712-9kbnyqt3 202 37 SLBs SLBs NNP cord-325712-9kbnyqt3 202 38 [ [ -LRB- cord-325712-9kbnyqt3 202 39 88 88 CD cord-325712-9kbnyqt3 202 40 , , , cord-325712-9kbnyqt3 202 41 89 89 CD cord-325712-9kbnyqt3 202 42 ] ] -RRB- cord-325712-9kbnyqt3 202 43 . . . cord-325712-9kbnyqt3 203 1 The the DT cord-325712-9kbnyqt3 203 2 affinity affinity NN cord-325712-9kbnyqt3 203 3 of of IN cord-325712-9kbnyqt3 203 4 glycoprotein glycoprotein NN cord-325712-9kbnyqt3 203 5 120 120 CD cord-325712-9kbnyqt3 203 6 for for IN cord-325712-9kbnyqt3 203 7 these these DT cord-325712-9kbnyqt3 203 8 lipids lipid NNS cord-325712-9kbnyqt3 203 9 is be VBZ cord-325712-9kbnyqt3 203 10 roughly roughly RB cord-325712-9kbnyqt3 203 11 5 5 CD cord-325712-9kbnyqt3 203 12 times time NNS cord-325712-9kbnyqt3 203 13 lower low JJR cord-325712-9kbnyqt3 203 14 than than IN cord-325712-9kbnyqt3 203 15 its -PRON- PRP$ cord-325712-9kbnyqt3 203 16 affinity affinity NN cord-325712-9kbnyqt3 203 17 for for IN cord-325712-9kbnyqt3 203 18 CD4 CD4 NNP cord-325712-9kbnyqt3 203 19 [ [ -LRB- cord-325712-9kbnyqt3 203 20 90 90 CD cord-325712-9kbnyqt3 203 21 ] ] -RRB- cord-325712-9kbnyqt3 203 22 . . . cord-325712-9kbnyqt3 204 1 The the DT cord-325712-9kbnyqt3 204 2 importance importance NN cord-325712-9kbnyqt3 204 3 of of IN cord-325712-9kbnyqt3 204 4 studying study VBG cord-325712-9kbnyqt3 204 5 the the DT cord-325712-9kbnyqt3 204 6 binding binding JJ cord-325712-9kbnyqt3 204 7 step step NN cord-325712-9kbnyqt3 204 8 is be VBZ cord-325712-9kbnyqt3 204 9 that that IN cord-325712-9kbnyqt3 204 10 the the DT cord-325712-9kbnyqt3 204 11 tropism tropism NN cord-325712-9kbnyqt3 204 12 of of IN cord-325712-9kbnyqt3 204 13 a a DT cord-325712-9kbnyqt3 204 14 virus virus NN cord-325712-9kbnyqt3 204 15 is be VBZ cord-325712-9kbnyqt3 204 16 strongly strongly RB cord-325712-9kbnyqt3 204 17 tied tie VBN cord-325712-9kbnyqt3 204 18 to to IN cord-325712-9kbnyqt3 204 19 its -PRON- PRP$ cord-325712-9kbnyqt3 204 20 ability ability NN cord-325712-9kbnyqt3 204 21 to to TO cord-325712-9kbnyqt3 204 22 bind bind VB cord-325712-9kbnyqt3 204 23 various various JJ cord-325712-9kbnyqt3 204 24 receptors receptor NNS cord-325712-9kbnyqt3 204 25 . . . cord-325712-9kbnyqt3 205 1 A a DT cord-325712-9kbnyqt3 205 2 nice nice JJ cord-325712-9kbnyqt3 205 3 example example NN cord-325712-9kbnyqt3 205 4 , , , cord-325712-9kbnyqt3 205 5 illustrating illustrate VBG cord-325712-9kbnyqt3 205 6 the the DT cord-325712-9kbnyqt3 205 7 power power NN cord-325712-9kbnyqt3 205 8 of of IN cord-325712-9kbnyqt3 205 9 combining combine VBG cord-325712-9kbnyqt3 205 10 single single JJ cord-325712-9kbnyqt3 205 11 virion virion NN cord-325712-9kbnyqt3 205 12 binding bind VBG cord-325712-9kbnyqt3 205 13 measurements measurement NNS cord-325712-9kbnyqt3 205 14 with with IN cord-325712-9kbnyqt3 205 15 cell cell NN cord-325712-9kbnyqt3 205 16 infectivity infectivity NN cord-325712-9kbnyqt3 205 17 studies study NNS cord-325712-9kbnyqt3 205 18 , , , cord-325712-9kbnyqt3 205 19 clearly clearly RB cord-325712-9kbnyqt3 205 20 showed show VBD cord-325712-9kbnyqt3 205 21 that that IN cord-325712-9kbnyqt3 205 22 a a DT cord-325712-9kbnyqt3 205 23 single single JJ cord-325712-9kbnyqt3 205 24 mutation mutation NN cord-325712-9kbnyqt3 205 25 in in IN cord-325712-9kbnyqt3 205 26 the the DT cord-325712-9kbnyqt3 205 27 canine canine JJ cord-325712-9kbnyqt3 205 28 parvovirus parvovirus NN cord-325712-9kbnyqt3 205 29 capsid capsid NN cord-325712-9kbnyqt3 205 30 is be VBZ cord-325712-9kbnyqt3 205 31 able able JJ cord-325712-9kbnyqt3 205 32 to to TO cord-325712-9kbnyqt3 205 33 alter alter VB cord-325712-9kbnyqt3 205 34 binding binding NN cord-325712-9kbnyqt3 205 35 to to IN cord-325712-9kbnyqt3 205 36 dog dog NN cord-325712-9kbnyqt3 205 37 and and CC cord-325712-9kbnyqt3 205 38 raccoon raccoon NN cord-325712-9kbnyqt3 205 39 transferrin transferrin NN cord-325712-9kbnyqt3 205 40 receptors receptor NNS cord-325712-9kbnyqt3 205 41 and and CC cord-325712-9kbnyqt3 205 42 completely completely RB cord-325712-9kbnyqt3 205 43 change change VB cord-325712-9kbnyqt3 205 44 the the DT cord-325712-9kbnyqt3 205 45 tropism tropism NN cord-325712-9kbnyqt3 205 46 of of IN cord-325712-9kbnyqt3 205 47 the the DT cord-325712-9kbnyqt3 205 48 virus virus NN cord-325712-9kbnyqt3 205 49 [ [ -LRB- cord-325712-9kbnyqt3 205 50 85 85 CD cord-325712-9kbnyqt3 205 51 ] ] -RRB- cord-325712-9kbnyqt3 205 52 . . . cord-325712-9kbnyqt3 206 1 Binding binding NN cord-325712-9kbnyqt3 206 2 can can MD cord-325712-9kbnyqt3 206 3 be be VB cord-325712-9kbnyqt3 206 4 monitored monitor VBN cord-325712-9kbnyqt3 206 5 using use VBG cord-325712-9kbnyqt3 206 6 ensemble ensemble NN cord-325712-9kbnyqt3 206 7 approaches approach NNS cord-325712-9kbnyqt3 206 8 that that WDT cord-325712-9kbnyqt3 206 9 monitor monitor VBP cord-325712-9kbnyqt3 206 10 the the DT cord-325712-9kbnyqt3 206 11 overall overall JJ cord-325712-9kbnyqt3 206 12 change change NN cord-325712-9kbnyqt3 206 13 in in IN cord-325712-9kbnyqt3 206 14 an an DT cord-325712-9kbnyqt3 206 15 aggregate aggregate JJ cord-325712-9kbnyqt3 206 16 signal signal NN cord-325712-9kbnyqt3 206 17 from from IN cord-325712-9kbnyqt3 206 18 many many JJ cord-325712-9kbnyqt3 206 19 virions virion NNS cord-325712-9kbnyqt3 206 20 interacting interact VBG cord-325712-9kbnyqt3 206 21 with with IN cord-325712-9kbnyqt3 206 22 a a DT cord-325712-9kbnyqt3 206 23 target target NN cord-325712-9kbnyqt3 206 24 surface surface NN cord-325712-9kbnyqt3 206 25 . . . cord-325712-9kbnyqt3 207 1 The the DT cord-325712-9kbnyqt3 207 2 simplest simple JJS cord-325712-9kbnyqt3 207 3 manner manner NN cord-325712-9kbnyqt3 207 4 to to TO cord-325712-9kbnyqt3 207 5 measure measure VB cord-325712-9kbnyqt3 207 6 virion virion NN cord-325712-9kbnyqt3 207 7 binding bind VBG cord-325712-9kbnyqt3 207 8 to to IN cord-325712-9kbnyqt3 207 9 a a DT cord-325712-9kbnyqt3 207 10 particular particular JJ cord-325712-9kbnyqt3 207 11 host host NN cord-325712-9kbnyqt3 207 12 cell cell NN cord-325712-9kbnyqt3 207 13 receptor receptor NN cord-325712-9kbnyqt3 207 14 is be VBZ cord-325712-9kbnyqt3 207 15 the the DT cord-325712-9kbnyqt3 207 16 cofloatation cofloatation NN cord-325712-9kbnyqt3 207 17 assay assay NN cord-325712-9kbnyqt3 207 18 . . . cord-325712-9kbnyqt3 208 1 In in IN cord-325712-9kbnyqt3 208 2 these these DT cord-325712-9kbnyqt3 208 3 assays assay NNS cord-325712-9kbnyqt3 208 4 , , , cord-325712-9kbnyqt3 208 5 viral viral JJ cord-325712-9kbnyqt3 208 6 particles particle NNS cord-325712-9kbnyqt3 208 7 or or CC cord-325712-9kbnyqt3 208 8 purified purify VBN cord-325712-9kbnyqt3 208 9 fusion fusion NN cord-325712-9kbnyqt3 208 10 proteins protein NNS cord-325712-9kbnyqt3 208 11 are be VBP cord-325712-9kbnyqt3 208 12 labeled label VBN cord-325712-9kbnyqt3 208 13 with with IN cord-325712-9kbnyqt3 208 14 a a DT cord-325712-9kbnyqt3 208 15 probe probe NN cord-325712-9kbnyqt3 208 16 and and CC cord-325712-9kbnyqt3 208 17 mixed mix VBN cord-325712-9kbnyqt3 208 18 with with IN cord-325712-9kbnyqt3 208 19 liposomes liposome NNS cord-325712-9kbnyqt3 208 20 containing contain VBG cord-325712-9kbnyqt3 208 21 the the DT cord-325712-9kbnyqt3 208 22 receptor receptor NN cord-325712-9kbnyqt3 208 23 for for IN cord-325712-9kbnyqt3 208 24 the the DT cord-325712-9kbnyqt3 208 25 virus virus NN cord-325712-9kbnyqt3 208 26 . . . cord-325712-9kbnyqt3 209 1 After after IN cord-325712-9kbnyqt3 209 2 the the DT cord-325712-9kbnyqt3 209 3 virus virus NN cord-325712-9kbnyqt3 209 4 has have VBZ cord-325712-9kbnyqt3 209 5 bound bind VBN cord-325712-9kbnyqt3 209 6 , , , cord-325712-9kbnyqt3 209 7 the the DT cord-325712-9kbnyqt3 209 8 mixture mixture NN cord-325712-9kbnyqt3 209 9 can can MD cord-325712-9kbnyqt3 209 10 then then RB cord-325712-9kbnyqt3 209 11 be be VB cord-325712-9kbnyqt3 209 12 added add VBN cord-325712-9kbnyqt3 209 13 to to IN cord-325712-9kbnyqt3 209 14 a a DT cord-325712-9kbnyqt3 209 15 sucrose sucrose NN cord-325712-9kbnyqt3 209 16 gradient gradient NN cord-325712-9kbnyqt3 209 17 and and CC cord-325712-9kbnyqt3 209 18 fractionated fractionate VBN cord-325712-9kbnyqt3 209 19 . . . cord-325712-9kbnyqt3 210 1 The the DT cord-325712-9kbnyqt3 210 2 fractions fraction NNS cord-325712-9kbnyqt3 210 3 are be VBP cord-325712-9kbnyqt3 210 4 analyzed analyze VBN cord-325712-9kbnyqt3 210 5 with with IN cord-325712-9kbnyqt3 210 6 PAGE page NN cord-325712-9kbnyqt3 210 7 or or CC cord-325712-9kbnyqt3 210 8 Western western JJ cord-325712-9kbnyqt3 210 9 Blot blot NN cord-325712-9kbnyqt3 210 10 to to TO cord-325712-9kbnyqt3 210 11 determine determine VB cord-325712-9kbnyqt3 210 12 under under IN cord-325712-9kbnyqt3 210 13 which which WDT cord-325712-9kbnyqt3 210 14 conditions condition VBZ cord-325712-9kbnyqt3 210 15 the the DT cord-325712-9kbnyqt3 210 16 virus virus NN cord-325712-9kbnyqt3 210 17 and and CC cord-325712-9kbnyqt3 210 18 liposomes liposome NNS cord-325712-9kbnyqt3 210 19 comigrate comigrate NNP cord-325712-9kbnyqt3 210 20 or or CC cord-325712-9kbnyqt3 210 21 cofloat cofloat JJ cord-325712-9kbnyqt3 210 22 [ [ -LRB- cord-325712-9kbnyqt3 210 23 91 91 CD cord-325712-9kbnyqt3 210 24 , , , cord-325712-9kbnyqt3 210 25 92 92 CD cord-325712-9kbnyqt3 210 26 ] ] -RRB- cord-325712-9kbnyqt3 210 27 . . . cord-325712-9kbnyqt3 211 1 Altering alter VBG cord-325712-9kbnyqt3 211 2 the the DT cord-325712-9kbnyqt3 211 3 composition composition NN cord-325712-9kbnyqt3 211 4 of of IN cord-325712-9kbnyqt3 211 5 the the DT cord-325712-9kbnyqt3 211 6 liposomes liposome NNS cord-325712-9kbnyqt3 211 7 can can MD cord-325712-9kbnyqt3 211 8 be be VB cord-325712-9kbnyqt3 211 9 used use VBN cord-325712-9kbnyqt3 211 10 to to TO cord-325712-9kbnyqt3 211 11 determine determine VB cord-325712-9kbnyqt3 211 12 what what WP cord-325712-9kbnyqt3 211 13 lipids lipid NNS cord-325712-9kbnyqt3 211 14 and and CC cord-325712-9kbnyqt3 211 15 proteins protein NNS cord-325712-9kbnyqt3 211 16 the the DT cord-325712-9kbnyqt3 211 17 virus virus NN cord-325712-9kbnyqt3 211 18 binds bind VBZ cord-325712-9kbnyqt3 211 19 to to IN cord-325712-9kbnyqt3 211 20 . . . cord-325712-9kbnyqt3 212 1 This this DT cord-325712-9kbnyqt3 212 2 assay assay NN cord-325712-9kbnyqt3 212 3 is be VBZ cord-325712-9kbnyqt3 212 4 able able JJ cord-325712-9kbnyqt3 212 5 to to TO cord-325712-9kbnyqt3 212 6 probe probe VB cord-325712-9kbnyqt3 212 7 virus virus NN cord-325712-9kbnyqt3 212 8 - - HYPH cord-325712-9kbnyqt3 212 9 receptor receptor NN cord-325712-9kbnyqt3 212 10 interactions interaction NNS cord-325712-9kbnyqt3 212 11 but but CC cord-325712-9kbnyqt3 212 12 does do VBZ cord-325712-9kbnyqt3 212 13 not not RB cord-325712-9kbnyqt3 212 14 provide provide VB cord-325712-9kbnyqt3 212 15 information information NN cord-325712-9kbnyqt3 212 16 on on IN cord-325712-9kbnyqt3 212 17 binding bind VBG cord-325712-9kbnyqt3 212 18 kinetics kinetic NNS cord-325712-9kbnyqt3 212 19 . . . cord-325712-9kbnyqt3 213 1 An an DT cord-325712-9kbnyqt3 213 2 additional additional JJ cord-325712-9kbnyqt3 213 3 limitation limitation NN cord-325712-9kbnyqt3 213 4 is be VBZ cord-325712-9kbnyqt3 213 5 that that IN cord-325712-9kbnyqt3 213 6 it -PRON- PRP cord-325712-9kbnyqt3 213 7 may may MD cord-325712-9kbnyqt3 213 8 be be VB cord-325712-9kbnyqt3 213 9 difficult difficult JJ cord-325712-9kbnyqt3 213 10 to to TO cord-325712-9kbnyqt3 213 11 purify purify VB cord-325712-9kbnyqt3 213 12 or or CC cord-325712-9kbnyqt3 213 13 prepare prepare VB cord-325712-9kbnyqt3 213 14 liposomes liposome NNS cord-325712-9kbnyqt3 213 15 containing contain VBG cord-325712-9kbnyqt3 213 16 the the DT cord-325712-9kbnyqt3 213 17 receptor receptor NN cord-325712-9kbnyqt3 213 18 , , , cord-325712-9kbnyqt3 213 19 particularly particularly RB cord-325712-9kbnyqt3 213 20 if if IN cord-325712-9kbnyqt3 213 21 it -PRON- PRP cord-325712-9kbnyqt3 213 22 is be VBZ cord-325712-9kbnyqt3 213 23 a a DT cord-325712-9kbnyqt3 213 24 transmembrane transmembrane NN cord-325712-9kbnyqt3 213 25 protein protein NN cord-325712-9kbnyqt3 213 26 . . . cord-325712-9kbnyqt3 214 1 Some some DT cord-325712-9kbnyqt3 214 2 ensemble ensemble NN cord-325712-9kbnyqt3 214 3 viral viral JJ cord-325712-9kbnyqt3 214 4 binding bind VBG cord-325712-9kbnyqt3 214 5 assays assay NNS cord-325712-9kbnyqt3 214 6 , , , cord-325712-9kbnyqt3 214 7 like like IN cord-325712-9kbnyqt3 214 8 enzyme enzyme NN cord-325712-9kbnyqt3 214 9 - - HYPH cord-325712-9kbnyqt3 214 10 linked link VBN cord-325712-9kbnyqt3 214 11 immunosorbent immunosorbent JJ cord-325712-9kbnyqt3 214 12 assay assay NN cord-325712-9kbnyqt3 214 13 ( ( -LRB- cord-325712-9kbnyqt3 214 14 ELISA ELISA NNP cord-325712-9kbnyqt3 214 15 ) ) -RRB- cord-325712-9kbnyqt3 214 16 or or CC cord-325712-9kbnyqt3 214 17 glycan glycan NN cord-325712-9kbnyqt3 214 18 arrays array NNS cord-325712-9kbnyqt3 214 19 , , , cord-325712-9kbnyqt3 214 20 immobilize immobilize VB cord-325712-9kbnyqt3 214 21 proteins protein NNS cord-325712-9kbnyqt3 214 22 , , , cord-325712-9kbnyqt3 214 23 carbohydrates carbohydrate NNS cord-325712-9kbnyqt3 214 24 , , , cord-325712-9kbnyqt3 214 25 or or CC cord-325712-9kbnyqt3 214 26 glycans glycan NNS cord-325712-9kbnyqt3 214 27 on on IN cord-325712-9kbnyqt3 214 28 a a DT cord-325712-9kbnyqt3 214 29 rigid rigid JJ cord-325712-9kbnyqt3 214 30 surface surface NN cord-325712-9kbnyqt3 214 31 . . . cord-325712-9kbnyqt3 215 1 These these DT cord-325712-9kbnyqt3 215 2 arrays array NNS cord-325712-9kbnyqt3 215 3 do do VBP cord-325712-9kbnyqt3 215 4 not not RB cord-325712-9kbnyqt3 215 5 preserve preserve VB cord-325712-9kbnyqt3 215 6 the the DT cord-325712-9kbnyqt3 215 7 structure structure NN cord-325712-9kbnyqt3 215 8 , , , cord-325712-9kbnyqt3 215 9 complexity complexity NN cord-325712-9kbnyqt3 215 10 , , , cord-325712-9kbnyqt3 215 11 or or CC cord-325712-9kbnyqt3 215 12 two two CD cord-325712-9kbnyqt3 215 13 - - HYPH cord-325712-9kbnyqt3 215 14 dimensional dimensional JJ cord-325712-9kbnyqt3 215 15 fluidity fluidity NN cord-325712-9kbnyqt3 215 16 of of IN cord-325712-9kbnyqt3 215 17 cellular cellular JJ cord-325712-9kbnyqt3 215 18 membranes membrane NNS cord-325712-9kbnyqt3 215 19 , , , cord-325712-9kbnyqt3 215 20 which which WDT cord-325712-9kbnyqt3 215 21 may may MD cord-325712-9kbnyqt3 215 22 limit limit VB cord-325712-9kbnyqt3 215 23 accurate accurate JJ cord-325712-9kbnyqt3 215 24 assessment assessment NN cord-325712-9kbnyqt3 215 25 of of IN cord-325712-9kbnyqt3 215 26 binding bind VBG cord-325712-9kbnyqt3 215 27 avidity avidity NN cord-325712-9kbnyqt3 215 28 . . . cord-325712-9kbnyqt3 216 1 However however RB cord-325712-9kbnyqt3 216 2 , , , cord-325712-9kbnyqt3 216 3 they -PRON- PRP cord-325712-9kbnyqt3 216 4 can can MD cord-325712-9kbnyqt3 216 5 be be VB cord-325712-9kbnyqt3 216 6 useful useful JJ cord-325712-9kbnyqt3 216 7 for for IN cord-325712-9kbnyqt3 216 8 rapidly rapidly RB cord-325712-9kbnyqt3 216 9 identifying identify VBG cord-325712-9kbnyqt3 216 10 binding bind VBG cord-325712-9kbnyqt3 216 11 partners partner NNS cord-325712-9kbnyqt3 216 12 in in IN cord-325712-9kbnyqt3 216 13 screening screening NN cord-325712-9kbnyqt3 216 14 , , , cord-325712-9kbnyqt3 216 15 for for IN cord-325712-9kbnyqt3 216 16 example example NN cord-325712-9kbnyqt3 216 17 , , , cord-325712-9kbnyqt3 216 18 potential potential JJ cord-325712-9kbnyqt3 216 19 tropism tropism NN cord-325712-9kbnyqt3 216 20 changes change NNS cord-325712-9kbnyqt3 216 21 [ [ -LRB- cord-325712-9kbnyqt3 216 22 93 93 CD cord-325712-9kbnyqt3 216 23 ] ] -RRB- cord-325712-9kbnyqt3 216 24 . . . cord-325712-9kbnyqt3 217 1 Measurements measurement NNS cord-325712-9kbnyqt3 217 2 of of IN cord-325712-9kbnyqt3 217 3 real real JJ cord-325712-9kbnyqt3 217 4 - - HYPH cord-325712-9kbnyqt3 217 5 time time NN cord-325712-9kbnyqt3 217 6 binding binding NN cord-325712-9kbnyqt3 217 7 and and CC cord-325712-9kbnyqt3 217 8 desorption desorption NN cord-325712-9kbnyqt3 217 9 can can MD cord-325712-9kbnyqt3 217 10 be be VB cord-325712-9kbnyqt3 217 11 assessed assess VBN cord-325712-9kbnyqt3 217 12 using use VBG cord-325712-9kbnyqt3 217 13 techniques technique NNS cord-325712-9kbnyqt3 217 14 like like IN cord-325712-9kbnyqt3 217 15 surface surface NN cord-325712-9kbnyqt3 217 16 plasmon plasmon JJ cord-325712-9kbnyqt3 217 17 resonance resonance NN cord-325712-9kbnyqt3 217 18 ( ( -LRB- cord-325712-9kbnyqt3 217 19 SPR SPR NNP cord-325712-9kbnyqt3 217 20 ) ) -RRB- cord-325712-9kbnyqt3 217 21 [ [ -LRB- cord-325712-9kbnyqt3 217 22 94 94 CD cord-325712-9kbnyqt3 217 23 ] ] -RRB- cord-325712-9kbnyqt3 217 24 and and CC cord-325712-9kbnyqt3 217 25 quartz quartz NN cord-325712-9kbnyqt3 217 26 crystal crystal NN cord-325712-9kbnyqt3 217 27 microbalance microbalance NN cord-325712-9kbnyqt3 217 28 with with IN cord-325712-9kbnyqt3 217 29 dissipation dissipation NN cord-325712-9kbnyqt3 217 30 ( ( -LRB- cord-325712-9kbnyqt3 217 31 QCM QCM NNP cord-325712-9kbnyqt3 217 32 - - HYPH cord-325712-9kbnyqt3 217 33 D D NNP cord-325712-9kbnyqt3 217 34 ) ) -RRB- cord-325712-9kbnyqt3 218 1 [ [ -LRB- cord-325712-9kbnyqt3 218 2 49 49 CD cord-325712-9kbnyqt3 218 3 , , , cord-325712-9kbnyqt3 218 4 95 95 CD cord-325712-9kbnyqt3 218 5 ] ] -RRB- cord-325712-9kbnyqt3 218 6 . . . cord-325712-9kbnyqt3 219 1 SPR SPR NNP cord-325712-9kbnyqt3 219 2 uses use VBZ cord-325712-9kbnyqt3 219 3 changes change NNS cord-325712-9kbnyqt3 219 4 in in IN cord-325712-9kbnyqt3 219 5 refractive refractive JJ cord-325712-9kbnyqt3 219 6 index index NN cord-325712-9kbnyqt3 219 7 to to TO cord-325712-9kbnyqt3 219 8 report report VB cord-325712-9kbnyqt3 219 9 the the DT cord-325712-9kbnyqt3 219 10 binding bind VBG cord-325712-9kbnyqt3 219 11 behavior behavior NN cord-325712-9kbnyqt3 219 12 , , , cord-325712-9kbnyqt3 219 13 while while IN cord-325712-9kbnyqt3 219 14 QCM QCM NNP cord-325712-9kbnyqt3 219 15 - - HYPH cord-325712-9kbnyqt3 219 16 D D NNP cord-325712-9kbnyqt3 219 17 uses use VBZ cord-325712-9kbnyqt3 219 18 a a DT cord-325712-9kbnyqt3 219 19 shift shift NN cord-325712-9kbnyqt3 219 20 in in IN cord-325712-9kbnyqt3 219 21 resonance resonance NN cord-325712-9kbnyqt3 219 22 frequency frequency NN cord-325712-9kbnyqt3 219 23 to to TO cord-325712-9kbnyqt3 219 24 report report VB cord-325712-9kbnyqt3 219 25 virus virus NN cord-325712-9kbnyqt3 219 26 interaction interaction NN cord-325712-9kbnyqt3 219 27 . . . cord-325712-9kbnyqt3 220 1 In in IN cord-325712-9kbnyqt3 220 2 both both DT cord-325712-9kbnyqt3 220 3 approaches approach NNS cord-325712-9kbnyqt3 220 4 , , , cord-325712-9kbnyqt3 220 5 biomimetic biomimetic JJ cord-325712-9kbnyqt3 220 6 membranes membrane NNS cord-325712-9kbnyqt3 220 7 can can MD cord-325712-9kbnyqt3 220 8 be be VB cord-325712-9kbnyqt3 220 9 used use VBN cord-325712-9kbnyqt3 220 10 to to TO cord-325712-9kbnyqt3 220 11 preserve preserve VB cord-325712-9kbnyqt3 220 12 many many JJ cord-325712-9kbnyqt3 220 13 properties property NNS cord-325712-9kbnyqt3 220 14 of of IN cord-325712-9kbnyqt3 220 15 the the DT cord-325712-9kbnyqt3 220 16 host host NN cord-325712-9kbnyqt3 220 17 cell cell NN cord-325712-9kbnyqt3 220 18 surface surface NN cord-325712-9kbnyqt3 220 19 , , , cord-325712-9kbnyqt3 220 20 including include VBG cord-325712-9kbnyqt3 220 21 integration integration NN cord-325712-9kbnyqt3 220 22 of of IN cord-325712-9kbnyqt3 220 23 the the DT cord-325712-9kbnyqt3 220 24 receptor receptor NN cord-325712-9kbnyqt3 220 25 . . . cord-325712-9kbnyqt3 221 1 Kinetic kinetic JJ cord-325712-9kbnyqt3 221 2 analysis analysis NN cord-325712-9kbnyqt3 221 3 of of IN cord-325712-9kbnyqt3 221 4 binding bind VBG cord-325712-9kbnyqt3 221 5 with with IN cord-325712-9kbnyqt3 221 6 these these DT cord-325712-9kbnyqt3 221 7 techniques technique NNS cord-325712-9kbnyqt3 221 8 requires require VBZ cord-325712-9kbnyqt3 221 9 two two CD cord-325712-9kbnyqt3 221 10 experimental experimental JJ cord-325712-9kbnyqt3 221 11 phases phase NNS cord-325712-9kbnyqt3 221 12 to to TO cord-325712-9kbnyqt3 221 13 decouple decouple VB cord-325712-9kbnyqt3 221 14 binding bind VBG cord-325712-9kbnyqt3 221 15 and and CC cord-325712-9kbnyqt3 221 16 unbinding unbinding NN cord-325712-9kbnyqt3 221 17 of of IN cord-325712-9kbnyqt3 221 18 virions virion NNS cord-325712-9kbnyqt3 221 19 . . . cord-325712-9kbnyqt3 222 1 In in IN cord-325712-9kbnyqt3 222 2 the the DT cord-325712-9kbnyqt3 222 3 first first JJ cord-325712-9kbnyqt3 222 4 phase phase NN cord-325712-9kbnyqt3 222 5 , , , cord-325712-9kbnyqt3 222 6 virions virion NNS cord-325712-9kbnyqt3 222 7 are be VBP cord-325712-9kbnyqt3 222 8 added add VBN cord-325712-9kbnyqt3 222 9 to to IN cord-325712-9kbnyqt3 222 10 a a DT cord-325712-9kbnyqt3 222 11 biomimetic biomimetic JJ cord-325712-9kbnyqt3 222 12 surface surface NN cord-325712-9kbnyqt3 222 13 and and CC cord-325712-9kbnyqt3 222 14 bind bind VB cord-325712-9kbnyqt3 222 15 to to IN cord-325712-9kbnyqt3 222 16 the the DT cord-325712-9kbnyqt3 222 17 receptors receptor NNS cord-325712-9kbnyqt3 222 18 . . . cord-325712-9kbnyqt3 223 1 In in IN cord-325712-9kbnyqt3 223 2 this this DT cord-325712-9kbnyqt3 223 3 way way NN cord-325712-9kbnyqt3 223 4 , , , cord-325712-9kbnyqt3 223 5 an an DT cord-325712-9kbnyqt3 223 6 " " `` cord-325712-9kbnyqt3 223 7 on on IN cord-325712-9kbnyqt3 223 8 " " `` cord-325712-9kbnyqt3 223 9 rate rate NN cord-325712-9kbnyqt3 223 10 can can MD cord-325712-9kbnyqt3 223 11 be be VB cord-325712-9kbnyqt3 223 12 obtained obtain VBN cord-325712-9kbnyqt3 223 13 . . . cord-325712-9kbnyqt3 224 1 In in IN cord-325712-9kbnyqt3 224 2 the the DT cord-325712-9kbnyqt3 224 3 second second JJ cord-325712-9kbnyqt3 224 4 phase phase NN cord-325712-9kbnyqt3 224 5 , , , cord-325712-9kbnyqt3 224 6 a a DT cord-325712-9kbnyqt3 224 7 virus virus NN cord-325712-9kbnyqt3 224 8 - - HYPH cord-325712-9kbnyqt3 224 9 free free JJ cord-325712-9kbnyqt3 224 10 buffer buffer NN cord-325712-9kbnyqt3 224 11 is be VBZ cord-325712-9kbnyqt3 224 12 added add VBN cord-325712-9kbnyqt3 224 13 and and CC cord-325712-9kbnyqt3 224 14 the the DT cord-325712-9kbnyqt3 224 15 dissociation dissociation NN cord-325712-9kbnyqt3 224 16 of of IN cord-325712-9kbnyqt3 224 17 the the DT cord-325712-9kbnyqt3 224 18 virus virus NN cord-325712-9kbnyqt3 224 19 from from IN cord-325712-9kbnyqt3 224 20 the the DT cord-325712-9kbnyqt3 224 21 receptor receptor NN cord-325712-9kbnyqt3 224 22 is be VBZ cord-325712-9kbnyqt3 224 23 monitored monitor VBN cord-325712-9kbnyqt3 224 24 . . . cord-325712-9kbnyqt3 225 1 In in IN cord-325712-9kbnyqt3 225 2 this this DT cord-325712-9kbnyqt3 225 3 arrangement arrangement NN cord-325712-9kbnyqt3 225 4 , , , cord-325712-9kbnyqt3 225 5 an an DT cord-325712-9kbnyqt3 225 6 " " `` cord-325712-9kbnyqt3 225 7 off off JJ cord-325712-9kbnyqt3 225 8 " " '' cord-325712-9kbnyqt3 225 9 rate rate NN cord-325712-9kbnyqt3 225 10 can can MD cord-325712-9kbnyqt3 225 11 be be VB cord-325712-9kbnyqt3 225 12 obtained obtain VBN cord-325712-9kbnyqt3 225 13 . . . cord-325712-9kbnyqt3 226 1 It -PRON- PRP cord-325712-9kbnyqt3 226 2 should should MD cord-325712-9kbnyqt3 226 3 be be VB cord-325712-9kbnyqt3 226 4 noted note VBN cord-325712-9kbnyqt3 226 5 that that IN cord-325712-9kbnyqt3 226 6 averaged average VBN cord-325712-9kbnyqt3 226 7 data datum NNS cord-325712-9kbnyqt3 226 8 from from IN cord-325712-9kbnyqt3 226 9 many many JJ cord-325712-9kbnyqt3 226 10 single single JJ cord-325712-9kbnyqt3 226 11 virion virion NN cord-325712-9kbnyqt3 226 12 tracking track VBG cord-325712-9kbnyqt3 226 13 binding/ binding/ NN cord-325712-9kbnyqt3 226 14 unbinding unbind VBG cord-325712-9kbnyqt3 226 15 events event NNS cord-325712-9kbnyqt3 226 16 should should MD cord-325712-9kbnyqt3 226 17 match match VB cord-325712-9kbnyqt3 226 18 the the DT cord-325712-9kbnyqt3 226 19 ensemble ensemble NN cord-325712-9kbnyqt3 226 20 results result NNS cord-325712-9kbnyqt3 226 21 generated generate VBN cord-325712-9kbnyqt3 226 22 with with IN cord-325712-9kbnyqt3 226 23 SPR SPR NNP cord-325712-9kbnyqt3 226 24 or or CC cord-325712-9kbnyqt3 226 25 QCM QCM NNP cord-325712-9kbnyqt3 226 26 - - HYPH cord-325712-9kbnyqt3 226 27 D. D. NNP cord-325712-9kbnyqt3 227 1 However however RB cord-325712-9kbnyqt3 227 2 , , , cord-325712-9kbnyqt3 227 3 direct direct JJ cord-325712-9kbnyqt3 227 4 imaging imaging NN cord-325712-9kbnyqt3 227 5 with with IN cord-325712-9kbnyqt3 227 6 single single JJ cord-325712-9kbnyqt3 227 7 virion virion NN cord-325712-9kbnyqt3 227 8 tracking tracking NN cord-325712-9kbnyqt3 227 9 allows allow VBZ cord-325712-9kbnyqt3 227 10 collection collection NN cord-325712-9kbnyqt3 227 11 of of IN cord-325712-9kbnyqt3 227 12 a a DT cord-325712-9kbnyqt3 227 13 richer rich JJR cord-325712-9kbnyqt3 227 14 set set NN cord-325712-9kbnyqt3 227 15 of of IN cord-325712-9kbnyqt3 227 16 data datum NNS cord-325712-9kbnyqt3 227 17 for for IN cord-325712-9kbnyqt3 227 18 on on IN cord-325712-9kbnyqt3 227 19 and and CC cord-325712-9kbnyqt3 227 20 off off JJ cord-325712-9kbnyqt3 227 21 rates rate NNS cord-325712-9kbnyqt3 227 22 simultaneously simultaneously RB cord-325712-9kbnyqt3 227 23 because because IN cord-325712-9kbnyqt3 227 24 each each DT cord-325712-9kbnyqt3 227 25 particle particle NN cord-325712-9kbnyqt3 227 26 trajectory trajectory NN cord-325712-9kbnyqt3 227 27 is be VBZ cord-325712-9kbnyqt3 227 28 captured capture VBN cord-325712-9kbnyqt3 227 29 [ [ -LRB- cord-325712-9kbnyqt3 227 30 37 37 CD cord-325712-9kbnyqt3 227 31 ] ] -RRB- cord-325712-9kbnyqt3 227 32 . . . cord-325712-9kbnyqt3 228 1 Furthermore furthermore RB cord-325712-9kbnyqt3 228 2 , , , cord-325712-9kbnyqt3 228 3 by by IN cord-325712-9kbnyqt3 228 4 having have VBG cord-325712-9kbnyqt3 228 5 the the DT cord-325712-9kbnyqt3 228 6 signature signature NN cord-325712-9kbnyqt3 228 7 of of IN cord-325712-9kbnyqt3 228 8 each each DT cord-325712-9kbnyqt3 228 9 individual individual JJ cord-325712-9kbnyqt3 228 10 virion virion NN cord-325712-9kbnyqt3 228 11 's 's POS cord-325712-9kbnyqt3 228 12 binding bind VBG cord-325712-9kbnyqt3 228 13 behavior behavior NN cord-325712-9kbnyqt3 228 14 , , , cord-325712-9kbnyqt3 228 15 heterogeneities heterogeneity NNS cord-325712-9kbnyqt3 228 16 in in IN cord-325712-9kbnyqt3 228 17 the the DT cord-325712-9kbnyqt3 228 18 virus virus NN cord-325712-9kbnyqt3 228 19 population population NN cord-325712-9kbnyqt3 228 20 or or CC cord-325712-9kbnyqt3 228 21 membrane membrane NN cord-325712-9kbnyqt3 228 22 surface surface NN cord-325712-9kbnyqt3 228 23 can can MD cord-325712-9kbnyqt3 228 24 be be VB cord-325712-9kbnyqt3 228 25 identified identify VBN cord-325712-9kbnyqt3 228 26 , , , cord-325712-9kbnyqt3 228 27 which which WDT cord-325712-9kbnyqt3 228 28 can can MD cord-325712-9kbnyqt3 228 29 then then RB cord-325712-9kbnyqt3 228 30 be be VB cord-325712-9kbnyqt3 228 31 compared compare VBN cord-325712-9kbnyqt3 228 32 to to IN cord-325712-9kbnyqt3 228 33 infection infection NN cord-325712-9kbnyqt3 228 34 trends trend NNS cord-325712-9kbnyqt3 228 35 to to TO cord-325712-9kbnyqt3 228 36 understand understand VB cord-325712-9kbnyqt3 228 37 how how WRB cord-325712-9kbnyqt3 228 38 population population NN cord-325712-9kbnyqt3 228 39 dispersity dispersity NN cord-325712-9kbnyqt3 228 40 impacts impact NNS cord-325712-9kbnyqt3 228 41 infection infection NN cord-325712-9kbnyqt3 228 42 [ [ -LRB- cord-325712-9kbnyqt3 228 43 96 96 CD cord-325712-9kbnyqt3 228 44 ] ] -RRB- cord-325712-9kbnyqt3 228 45 . . . cord-325712-9kbnyqt3 229 1 Internalization internalization NN cord-325712-9kbnyqt3 229 2 , , , cord-325712-9kbnyqt3 229 3 or or CC cord-325712-9kbnyqt3 229 4 the the DT cord-325712-9kbnyqt3 229 5 uptake uptake NN cord-325712-9kbnyqt3 229 6 of of IN cord-325712-9kbnyqt3 229 7 the the DT cord-325712-9kbnyqt3 229 8 virus virus NN cord-325712-9kbnyqt3 229 9 particle particle NN cord-325712-9kbnyqt3 229 10 into into IN cord-325712-9kbnyqt3 229 11 the the DT cord-325712-9kbnyqt3 229 12 cytosol cytosol NN cord-325712-9kbnyqt3 229 13 , , , cord-325712-9kbnyqt3 229 14 can can MD cord-325712-9kbnyqt3 229 15 be be VB cord-325712-9kbnyqt3 229 16 assessed assess VBN cord-325712-9kbnyqt3 229 17 either either CC cord-325712-9kbnyqt3 229 18 with with IN cord-325712-9kbnyqt3 229 19 live live JJ cord-325712-9kbnyqt3 229 20 cell cell NN cord-325712-9kbnyqt3 229 21 imaging imaging NN cord-325712-9kbnyqt3 229 22 or or CC cord-325712-9kbnyqt3 229 23 in in IN cord-325712-9kbnyqt3 229 24 fixed fix VBN cord-325712-9kbnyqt3 229 25 cells cell NNS cord-325712-9kbnyqt3 229 26 through through IN cord-325712-9kbnyqt3 229 27 immunofluorescence immunofluorescence NN cord-325712-9kbnyqt3 229 28 imaging imaging NN cord-325712-9kbnyqt3 229 29 . . . cord-325712-9kbnyqt3 230 1 In in IN cord-325712-9kbnyqt3 230 2 live live JJ cord-325712-9kbnyqt3 230 3 cell cell NN cord-325712-9kbnyqt3 230 4 virion virion NN cord-325712-9kbnyqt3 230 5 tracking tracking NN cord-325712-9kbnyqt3 230 6 , , , cord-325712-9kbnyqt3 230 7 cellular cellular JJ cord-325712-9kbnyqt3 230 8 components component NNS cord-325712-9kbnyqt3 230 9 , , , cord-325712-9kbnyqt3 230 10 like like IN cord-325712-9kbnyqt3 230 11 clathrin clathrin NN cord-325712-9kbnyqt3 230 12 and and CC cord-325712-9kbnyqt3 230 13 caveolin caveolin NNP cord-325712-9kbnyqt3 230 14 , , , cord-325712-9kbnyqt3 230 15 can can MD cord-325712-9kbnyqt3 230 16 be be VB cord-325712-9kbnyqt3 230 17 fluorescently fluorescently RB cord-325712-9kbnyqt3 230 18 labeled label VBN cord-325712-9kbnyqt3 230 19 and and CC cord-325712-9kbnyqt3 230 20 colocalization colocalization NN cord-325712-9kbnyqt3 230 21 of of IN cord-325712-9kbnyqt3 230 22 these these DT cord-325712-9kbnyqt3 230 23 components component NNS cord-325712-9kbnyqt3 230 24 with with IN cord-325712-9kbnyqt3 230 25 virions virion NNS cord-325712-9kbnyqt3 230 26 enables enable VBZ cord-325712-9kbnyqt3 230 27 determination determination NN cord-325712-9kbnyqt3 230 28 of of IN cord-325712-9kbnyqt3 230 29 whether whether IN cord-325712-9kbnyqt3 230 30 the the DT cord-325712-9kbnyqt3 230 31 primary primary JJ cord-325712-9kbnyqt3 230 32 means mean NNS cord-325712-9kbnyqt3 230 33 of of IN cord-325712-9kbnyqt3 230 34 viral viral JJ cord-325712-9kbnyqt3 230 35 entry entry NN cord-325712-9kbnyqt3 230 36 is be VBZ cord-325712-9kbnyqt3 230 37 through through IN cord-325712-9kbnyqt3 230 38 clathrin clathrin NN cord-325712-9kbnyqt3 230 39 - - HYPH cord-325712-9kbnyqt3 230 40 dependent dependent JJ cord-325712-9kbnyqt3 230 41 endocytosis endocytosis NN cord-325712-9kbnyqt3 230 42 , , , cord-325712-9kbnyqt3 230 43 caveolin caveolin JJ cord-325712-9kbnyqt3 230 44 - - HYPH cord-325712-9kbnyqt3 230 45 dependent dependent JJ cord-325712-9kbnyqt3 230 46 endocytosis endocytosis NN cord-325712-9kbnyqt3 230 47 , , , cord-325712-9kbnyqt3 230 48 or or CC cord-325712-9kbnyqt3 230 49 a a DT cord-325712-9kbnyqt3 230 50 clathrin clathrin NN cord-325712-9kbnyqt3 230 51 / / SYM cord-325712-9kbnyqt3 230 52 caveolin caveolin JJ cord-325712-9kbnyqt3 230 53 independent independent JJ cord-325712-9kbnyqt3 230 54 uptake uptake NN cord-325712-9kbnyqt3 230 55 mechanism mechanism NN cord-325712-9kbnyqt3 230 56 . . . cord-325712-9kbnyqt3 231 1 When when WRB cord-325712-9kbnyqt3 231 2 tracking track VBG cord-325712-9kbnyqt3 231 3 labeled label VBN cord-325712-9kbnyqt3 231 4 virions virion NNS cord-325712-9kbnyqt3 231 5 on on IN cord-325712-9kbnyqt3 231 6 live live JJ cord-325712-9kbnyqt3 231 7 cells cell NNS cord-325712-9kbnyqt3 231 8 , , , cord-325712-9kbnyqt3 231 9 rapid rapid JJ cord-325712-9kbnyqt3 231 10 unidirectional unidirectional JJ cord-325712-9kbnyqt3 231 11 motion motion NN cord-325712-9kbnyqt3 231 12 indicates indicate VBZ cord-325712-9kbnyqt3 231 13 that that IN cord-325712-9kbnyqt3 231 14 particles particle NNS cord-325712-9kbnyqt3 231 15 have have VBP cord-325712-9kbnyqt3 231 16 been be VBN cord-325712-9kbnyqt3 231 17 internalized internalize VBN cord-325712-9kbnyqt3 231 18 [ [ -LRB- cord-325712-9kbnyqt3 231 19 70 70 CD cord-325712-9kbnyqt3 231 20 , , , cord-325712-9kbnyqt3 231 21 78 78 CD cord-325712-9kbnyqt3 231 22 , , , cord-325712-9kbnyqt3 231 23 97 97 CD cord-325712-9kbnyqt3 231 24 ] ] -RRB- cord-325712-9kbnyqt3 231 25 . . . cord-325712-9kbnyqt3 232 1 Live live JJ cord-325712-9kbnyqt3 232 2 - - HYPH cord-325712-9kbnyqt3 232 3 cell cell NN cord-325712-9kbnyqt3 232 4 tracking tracking NN cord-325712-9kbnyqt3 232 5 has have VBZ cord-325712-9kbnyqt3 232 6 revealed reveal VBN cord-325712-9kbnyqt3 232 7 myriad myriad JJ cord-325712-9kbnyqt3 232 8 information information NN cord-325712-9kbnyqt3 232 9 about about IN cord-325712-9kbnyqt3 232 10 virus virus NN cord-325712-9kbnyqt3 232 11 internalization internalization NN cord-325712-9kbnyqt3 232 12 , , , cord-325712-9kbnyqt3 232 13 including include VBG cord-325712-9kbnyqt3 232 14 identifying identify VBG cord-325712-9kbnyqt3 232 15 viral viral JJ cord-325712-9kbnyqt3 232 16 dependence dependence NN cord-325712-9kbnyqt3 232 17 on on IN cord-325712-9kbnyqt3 232 18 clathrin clathrin NN cord-325712-9kbnyqt3 232 19 or or CC cord-325712-9kbnyqt3 232 20 caveolin caveolin NN cord-325712-9kbnyqt3 232 21 for for IN cord-325712-9kbnyqt3 232 22 uptake uptake NN cord-325712-9kbnyqt3 232 23 as as RB cord-325712-9kbnyqt3 232 24 well well RB cord-325712-9kbnyqt3 232 25 as as IN cord-325712-9kbnyqt3 232 26 the the DT cord-325712-9kbnyqt3 232 27 ability ability NN cord-325712-9kbnyqt3 232 28 of of IN cord-325712-9kbnyqt3 232 29 viruses virus NNS cord-325712-9kbnyqt3 232 30 to to TO cord-325712-9kbnyqt3 232 31 promote promote VB cord-325712-9kbnyqt3 232 32 their -PRON- PRP$ cord-325712-9kbnyqt3 232 33 own own JJ cord-325712-9kbnyqt3 232 34 uptake uptake NN cord-325712-9kbnyqt3 232 35 . . . cord-325712-9kbnyqt3 233 1 For for IN cord-325712-9kbnyqt3 233 2 example example NN cord-325712-9kbnyqt3 233 3 , , , cord-325712-9kbnyqt3 233 4 Reovirus Reovirus NNP cord-325712-9kbnyqt3 233 5 induces induce VBZ cord-325712-9kbnyqt3 233 6 the the DT cord-325712-9kbnyqt3 233 7 formation formation NN cord-325712-9kbnyqt3 233 8 of of IN cord-325712-9kbnyqt3 233 9 clathrin clathrin NN cord-325712-9kbnyqt3 233 10 - - HYPH cord-325712-9kbnyqt3 233 11 coated coat VBN cord-325712-9kbnyqt3 233 12 pits pit NNS cord-325712-9kbnyqt3 233 13 for for IN cord-325712-9kbnyqt3 233 14 uptake uptake NN cord-325712-9kbnyqt3 233 15 [ [ -LRB- cord-325712-9kbnyqt3 233 16 97 97 CD cord-325712-9kbnyqt3 233 17 ] ] -RRB- cord-325712-9kbnyqt3 233 18 . . . cord-325712-9kbnyqt3 234 1 Simian simian JJ cord-325712-9kbnyqt3 234 2 virus virus NN cord-325712-9kbnyqt3 234 3 40 40 CD cord-325712-9kbnyqt3 234 4 has have VBZ cord-325712-9kbnyqt3 234 5 the the DT cord-325712-9kbnyqt3 234 6 ability ability NN cord-325712-9kbnyqt3 234 7 to to TO cord-325712-9kbnyqt3 234 8 induce induce VB cord-325712-9kbnyqt3 234 9 actin actin JJ cord-325712-9kbnyqt3 234 10 rearrangement rearrangement NN cord-325712-9kbnyqt3 234 11 to to TO cord-325712-9kbnyqt3 234 12 further further RB cord-325712-9kbnyqt3 234 13 promote promote VB cord-325712-9kbnyqt3 234 14 its -PRON- PRP$ cord-325712-9kbnyqt3 234 15 own own JJ cord-325712-9kbnyqt3 234 16 internalization internalization NN cord-325712-9kbnyqt3 234 17 whereas whereas IN cord-325712-9kbnyqt3 234 18 echovirus echovirus NNP cord-325712-9kbnyqt3 234 19 1 1 CD cord-325712-9kbnyqt3 234 20 does do VBZ cord-325712-9kbnyqt3 234 21 not not RB cord-325712-9kbnyqt3 234 22 [ [ -LRB- cord-325712-9kbnyqt3 234 23 71 71 CD cord-325712-9kbnyqt3 234 24 , , , cord-325712-9kbnyqt3 234 25 98 98 CD cord-325712-9kbnyqt3 234 26 ] ] -RRB- cord-325712-9kbnyqt3 234 27 . . . cord-325712-9kbnyqt3 235 1 Clathrin Clathrin NNP cord-325712-9kbnyqt3 235 2 - - HYPH cord-325712-9kbnyqt3 235 3 mediated mediate VBN cord-325712-9kbnyqt3 235 4 endocytosis endocytosis NN cord-325712-9kbnyqt3 235 5 is be VBZ cord-325712-9kbnyqt3 235 6 utilized utilize VBN cord-325712-9kbnyqt3 235 7 for for IN cord-325712-9kbnyqt3 235 8 the the DT cord-325712-9kbnyqt3 235 9 uptake uptake NN cord-325712-9kbnyqt3 235 10 of of IN cord-325712-9kbnyqt3 235 11 many many JJ cord-325712-9kbnyqt3 235 12 viruses virus NNS cord-325712-9kbnyqt3 235 13 including include VBG cord-325712-9kbnyqt3 235 14 Australian australian JJ cord-325712-9kbnyqt3 235 15 bat bat NN cord-325712-9kbnyqt3 235 16 lyssavirus lyssavirus NN cord-325712-9kbnyqt3 235 17 [ [ -LRB- cord-325712-9kbnyqt3 235 18 99 99 CD cord-325712-9kbnyqt3 235 19 ] ] -RRB- cord-325712-9kbnyqt3 235 20 , , , cord-325712-9kbnyqt3 235 21 HIV HIV NNP cord-325712-9kbnyqt3 235 22 [ [ -LRB- cord-325712-9kbnyqt3 235 23 100 100 CD cord-325712-9kbnyqt3 235 24 ] ] -RRB- cord-325712-9kbnyqt3 235 25 , , , cord-325712-9kbnyqt3 235 26 infectious infectious JJ cord-325712-9kbnyqt3 235 27 hematopoietic hematopoietic JJ cord-325712-9kbnyqt3 235 28 necrosis necrosis NN cord-325712-9kbnyqt3 235 29 virus virus NN cord-325712-9kbnyqt3 235 30 [ [ -LRB- cord-325712-9kbnyqt3 235 31 101 101 CD cord-325712-9kbnyqt3 235 32 ] ] -RRB- cord-325712-9kbnyqt3 235 33 , , , cord-325712-9kbnyqt3 235 34 and and CC cord-325712-9kbnyqt3 235 35 rabiesvirus rabiesvirus NNP cord-325712-9kbnyqt3 235 36 [ [ -LRB- cord-325712-9kbnyqt3 235 37 74 74 CD cord-325712-9kbnyqt3 235 38 ] ] -RRB- cord-325712-9kbnyqt3 235 39 . . . cord-325712-9kbnyqt3 236 1 Other other JJ cord-325712-9kbnyqt3 236 2 viruses virus NNS cord-325712-9kbnyqt3 236 3 are be VBP cord-325712-9kbnyqt3 236 4 caveolinindependent caveolinindependent JJ cord-325712-9kbnyqt3 236 5 or or CC cord-325712-9kbnyqt3 236 6 use use VB cord-325712-9kbnyqt3 236 7 macropinocytosis macropinocytosis NN cord-325712-9kbnyqt3 236 8 . . . cord-325712-9kbnyqt3 237 1 For for IN cord-325712-9kbnyqt3 237 2 example example NN cord-325712-9kbnyqt3 237 3 , , , cord-325712-9kbnyqt3 237 4 mouse mouse NNP cord-325712-9kbnyqt3 237 5 polyomavirus polyomavirus NNP cord-325712-9kbnyqt3 237 6 is be VBZ cord-325712-9kbnyqt3 237 7 also also RB cord-325712-9kbnyqt3 237 8 delivered deliver VBN cord-325712-9kbnyqt3 237 9 to to IN cord-325712-9kbnyqt3 237 10 early early JJ cord-325712-9kbnyqt3 237 11 endosomes endosome NNS cord-325712-9kbnyqt3 237 12 by by IN cord-325712-9kbnyqt3 237 13 a a DT cord-325712-9kbnyqt3 237 14 caveolin caveolin JJ cord-325712-9kbnyqt3 237 15 independent independent JJ cord-325712-9kbnyqt3 237 16 pathway pathway NN cord-325712-9kbnyqt3 237 17 [ [ -LRB- cord-325712-9kbnyqt3 237 18 102 102 CD cord-325712-9kbnyqt3 237 19 ] ] -RRB- cord-325712-9kbnyqt3 237 20 . . . cord-325712-9kbnyqt3 238 1 Adenovirus Adenovirus NNP cord-325712-9kbnyqt3 238 2 2 2 CD cord-325712-9kbnyqt3 238 3 enters enter VBZ cord-325712-9kbnyqt3 238 4 the the DT cord-325712-9kbnyqt3 238 5 cell cell NN cord-325712-9kbnyqt3 238 6 viaboth viaboth NNP cord-325712-9kbnyqt3 238 7 clathrin clathrin NN cord-325712-9kbnyqt3 238 8 dependent dependent JJ cord-325712-9kbnyqt3 238 9 and and CC cord-325712-9kbnyqt3 238 10 independent independent JJ cord-325712-9kbnyqt3 238 11 endocytosis endocytosis NN cord-325712-9kbnyqt3 238 12 and and CC cord-325712-9kbnyqt3 238 13 triggers trigger VBZ cord-325712-9kbnyqt3 238 14 macropinocytosis macropinocytosis NNP cord-325712-9kbnyqt3 238 15 [ [ -LRB- cord-325712-9kbnyqt3 238 16 103 103 CD cord-325712-9kbnyqt3 238 17 ] ] -RRB- cord-325712-9kbnyqt3 238 18 [ [ -LRB- cord-325712-9kbnyqt3 238 19 104 104 CD cord-325712-9kbnyqt3 238 20 ] ] -RRB- cord-325712-9kbnyqt3 238 21 [ [ -LRB- cord-325712-9kbnyqt3 238 22 105 105 CD cord-325712-9kbnyqt3 238 23 ] ] -RRB- cord-325712-9kbnyqt3 238 24 [ [ -LRB- cord-325712-9kbnyqt3 238 25 106 106 CD cord-325712-9kbnyqt3 238 26 ] ] -RRB- cord-325712-9kbnyqt3 238 27 . . . cord-325712-9kbnyqt3 239 1 Still still RB cord-325712-9kbnyqt3 239 2 other other JJ cord-325712-9kbnyqt3 239 3 viruses virus NNS cord-325712-9kbnyqt3 239 4 have have VBP cord-325712-9kbnyqt3 239 5 been be VBN cord-325712-9kbnyqt3 239 6 shown show VBN cord-325712-9kbnyqt3 239 7 to to TO cord-325712-9kbnyqt3 239 8 be be VB cord-325712-9kbnyqt3 239 9 agile agile JJ cord-325712-9kbnyqt3 239 10 in in IN cord-325712-9kbnyqt3 239 11 their -PRON- PRP$ cord-325712-9kbnyqt3 239 12 internalization internalization NN cord-325712-9kbnyqt3 239 13 route route NN cord-325712-9kbnyqt3 239 14 , , , cord-325712-9kbnyqt3 239 15 for for IN cord-325712-9kbnyqt3 239 16 example example NN cord-325712-9kbnyqt3 239 17 , , , cord-325712-9kbnyqt3 239 18 in in IN cord-325712-9kbnyqt3 239 19 the the DT cord-325712-9kbnyqt3 239 20 absence absence NN cord-325712-9kbnyqt3 239 21 of of IN cord-325712-9kbnyqt3 239 22 caveolin caveolin JJ cord-325712-9kbnyqt3 239 23 , , , cord-325712-9kbnyqt3 239 24 simian simian JJ cord-325712-9kbnyqt3 239 25 virus virus NN cord-325712-9kbnyqt3 239 26 40 40 CD cord-325712-9kbnyqt3 239 27 can can MD cord-325712-9kbnyqt3 239 28 exploit exploit VB cord-325712-9kbnyqt3 239 29 a a DT cord-325712-9kbnyqt3 239 30 clathrin clathrin NN cord-325712-9kbnyqt3 239 31 / / SYM cord-325712-9kbnyqt3 239 32 caveolin caveolin JJ cord-325712-9kbnyqt3 239 33 independent independent JJ cord-325712-9kbnyqt3 239 34 pathway pathway NN cord-325712-9kbnyqt3 239 35 [ [ -LRB- cord-325712-9kbnyqt3 239 36 107 107 CD cord-325712-9kbnyqt3 239 37 ] ] -RRB- cord-325712-9kbnyqt3 239 38 . . . cord-325712-9kbnyqt3 240 1 Studies study NNS cord-325712-9kbnyqt3 240 2 have have VBP cord-325712-9kbnyqt3 240 3 shown show VBN cord-325712-9kbnyqt3 240 4 that that WDT cord-325712-9kbnyqt3 240 5 bound bind VBN cord-325712-9kbnyqt3 240 6 influenza influenza NN cord-325712-9kbnyqt3 240 7 virions virion NNS cord-325712-9kbnyqt3 240 8 have have VBP cord-325712-9kbnyqt3 240 9 the the DT cord-325712-9kbnyqt3 240 10 ability ability NN cord-325712-9kbnyqt3 240 11 to to TO cord-325712-9kbnyqt3 240 12 induce induce VB cord-325712-9kbnyqt3 240 13 the the DT cord-325712-9kbnyqt3 240 14 formation formation NN cord-325712-9kbnyqt3 240 15 of of IN cord-325712-9kbnyqt3 240 16 clathrin clathrin NN cord-325712-9kbnyqt3 240 17 - - HYPH cord-325712-9kbnyqt3 240 18 coated coat VBN cord-325712-9kbnyqt3 240 19 pits pit NNS cord-325712-9kbnyqt3 240 20 , , , cord-325712-9kbnyqt3 240 21 but but CC cord-325712-9kbnyqt3 240 22 can can MD cord-325712-9kbnyqt3 240 23 also also RB cord-325712-9kbnyqt3 240 24 enter enter VB cord-325712-9kbnyqt3 240 25 in in IN cord-325712-9kbnyqt3 240 26 a a DT cord-325712-9kbnyqt3 240 27 clathrin clathrin NN cord-325712-9kbnyqt3 240 28 / / SYM cord-325712-9kbnyqt3 240 29 caveolin caveolin JJ cord-325712-9kbnyqt3 240 30 independent independent JJ cord-325712-9kbnyqt3 240 31 manner manner NN cord-325712-9kbnyqt3 240 32 [ [ -LRB- cord-325712-9kbnyqt3 240 33 78 78 CD cord-325712-9kbnyqt3 240 34 ] ] -RRB- cord-325712-9kbnyqt3 240 35 . . . cord-325712-9kbnyqt3 241 1 Influenza influenza NN cord-325712-9kbnyqt3 241 2 is be VBZ cord-325712-9kbnyqt3 241 3 then then RB cord-325712-9kbnyqt3 241 4 preferentially preferentially RB cord-325712-9kbnyqt3 241 5 sorted sort VBN cord-325712-9kbnyqt3 241 6 into into IN cord-325712-9kbnyqt3 241 7 a a DT cord-325712-9kbnyqt3 241 8 population population NN cord-325712-9kbnyqt3 241 9 of of IN cord-325712-9kbnyqt3 241 10 early early JJ cord-325712-9kbnyqt3 241 11 endosomes endosome NNS cord-325712-9kbnyqt3 241 12 that that WDT cord-325712-9kbnyqt3 241 13 quickly quickly RB cord-325712-9kbnyqt3 241 14 matures mature VBZ cord-325712-9kbnyqt3 241 15 [ [ -LRB- cord-325712-9kbnyqt3 241 16 108 108 CD cord-325712-9kbnyqt3 241 17 ] ] -RRB- cord-325712-9kbnyqt3 241 18 . . . cord-325712-9kbnyqt3 242 1 To to TO cord-325712-9kbnyqt3 242 2 monitor monitor VB cord-325712-9kbnyqt3 242 3 virus virus NN cord-325712-9kbnyqt3 242 4 entry entry NN cord-325712-9kbnyqt3 242 5 without without IN cord-325712-9kbnyqt3 242 6 live live JJ cord-325712-9kbnyqt3 242 7 cell cell NN cord-325712-9kbnyqt3 242 8 particle particle NN cord-325712-9kbnyqt3 242 9 tracking tracking NN cord-325712-9kbnyqt3 242 10 , , , cord-325712-9kbnyqt3 242 11 infected infected JJ cord-325712-9kbnyqt3 242 12 cells cell NNS cord-325712-9kbnyqt3 242 13 can can MD cord-325712-9kbnyqt3 242 14 be be VB cord-325712-9kbnyqt3 242 15 fixed fix VBN cord-325712-9kbnyqt3 242 16 and and CC cord-325712-9kbnyqt3 242 17 imaged image VBN cord-325712-9kbnyqt3 242 18 with with IN cord-325712-9kbnyqt3 242 19 an an DT cord-325712-9kbnyqt3 242 20 immunofluorescence immunofluorescence NN cord-325712-9kbnyqt3 242 21 assay assay NN cord-325712-9kbnyqt3 242 22 . . . cord-325712-9kbnyqt3 243 1 Permeablized permeablized JJ cord-325712-9kbnyqt3 243 2 cells cell NNS cord-325712-9kbnyqt3 243 3 can can MD cord-325712-9kbnyqt3 243 4 be be VB cord-325712-9kbnyqt3 243 5 probed probe VBN cord-325712-9kbnyqt3 243 6 with with IN cord-325712-9kbnyqt3 243 7 antibodies antibody NNS cord-325712-9kbnyqt3 243 8 against against IN cord-325712-9kbnyqt3 243 9 viral viral JJ cord-325712-9kbnyqt3 243 10 proteins protein NNS cord-325712-9kbnyqt3 243 11 , , , cord-325712-9kbnyqt3 243 12 and and CC cord-325712-9kbnyqt3 243 13 cytoskeletal cytoskeletal JJ cord-325712-9kbnyqt3 243 14 elements element NNS cord-325712-9kbnyqt3 243 15 , , , cord-325712-9kbnyqt3 243 16 or or CC cord-325712-9kbnyqt3 243 17 endocytosis endocytosis NN cord-325712-9kbnyqt3 243 18 markers marker NNS cord-325712-9kbnyqt3 243 19 . . . cord-325712-9kbnyqt3 244 1 Colocalization colocalization NN cord-325712-9kbnyqt3 244 2 of of IN cord-325712-9kbnyqt3 244 3 viral viral JJ cord-325712-9kbnyqt3 244 4 particles particle NNS cord-325712-9kbnyqt3 244 5 and and CC cord-325712-9kbnyqt3 244 6 cellular cellular JJ cord-325712-9kbnyqt3 244 7 components component NNS cord-325712-9kbnyqt3 244 8 can can MD cord-325712-9kbnyqt3 244 9 then then RB cord-325712-9kbnyqt3 244 10 reveal reveal VB cord-325712-9kbnyqt3 244 11 the the DT cord-325712-9kbnyqt3 244 12 general general JJ cord-325712-9kbnyqt3 244 13 entry entry NN cord-325712-9kbnyqt3 244 14 pathway pathway NN cord-325712-9kbnyqt3 244 15 of of IN cord-325712-9kbnyqt3 244 16 the the DT cord-325712-9kbnyqt3 244 17 virus virus NN cord-325712-9kbnyqt3 244 18 [ [ -LRB- cord-325712-9kbnyqt3 244 19 109 109 CD cord-325712-9kbnyqt3 244 20 ] ] -RRB- cord-325712-9kbnyqt3 244 21 [ [ -LRB- cord-325712-9kbnyqt3 244 22 110 110 CD cord-325712-9kbnyqt3 244 23 ] ] -RRB- cord-325712-9kbnyqt3 244 24 [ [ -LRB- cord-325712-9kbnyqt3 244 25 111 111 CD cord-325712-9kbnyqt3 244 26 ] ] -RRB- cord-325712-9kbnyqt3 244 27 . . . cord-325712-9kbnyqt3 245 1 Cells cell NNS cord-325712-9kbnyqt3 245 2 can can MD cord-325712-9kbnyqt3 245 3 be be VB cord-325712-9kbnyqt3 245 4 fixed fix VBN cord-325712-9kbnyqt3 245 5 at at IN cord-325712-9kbnyqt3 245 6 various various JJ cord-325712-9kbnyqt3 245 7 time time NN cord-325712-9kbnyqt3 245 8 points point NNS cord-325712-9kbnyqt3 245 9 after after IN cord-325712-9kbnyqt3 245 10 infection infection NN cord-325712-9kbnyqt3 245 11 to to TO cord-325712-9kbnyqt3 245 12 determine determine VB cord-325712-9kbnyqt3 245 13 the the DT cord-325712-9kbnyqt3 245 14 general general JJ cord-325712-9kbnyqt3 245 15 time time NN cord-325712-9kbnyqt3 245 16 course course NN cord-325712-9kbnyqt3 245 17 of of IN cord-325712-9kbnyqt3 245 18 entry entry NN cord-325712-9kbnyqt3 245 19 [ [ -LRB- cord-325712-9kbnyqt3 245 20 112 112 CD cord-325712-9kbnyqt3 245 21 , , , cord-325712-9kbnyqt3 245 22 113 113 CD cord-325712-9kbnyqt3 245 23 ] ] -RRB- cord-325712-9kbnyqt3 245 24 . . . cord-325712-9kbnyqt3 246 1 This this DT cord-325712-9kbnyqt3 246 2 method method NN cord-325712-9kbnyqt3 246 3 provides provide VBZ cord-325712-9kbnyqt3 246 4 snapshots snapshot NNS cord-325712-9kbnyqt3 246 5 of of IN cord-325712-9kbnyqt3 246 6 the the DT cord-325712-9kbnyqt3 246 7 viral viral JJ cord-325712-9kbnyqt3 246 8 entry entry NN cord-325712-9kbnyqt3 246 9 process process NN cord-325712-9kbnyqt3 246 10 because because IN cord-325712-9kbnyqt3 246 11 the the DT cord-325712-9kbnyqt3 246 12 cells cell NNS cord-325712-9kbnyqt3 246 13 are be VBP cord-325712-9kbnyqt3 246 14 fixed fix VBN cord-325712-9kbnyqt3 246 15 before before IN cord-325712-9kbnyqt3 246 16 imaging image VBG cord-325712-9kbnyqt3 246 17 , , , cord-325712-9kbnyqt3 246 18 but but CC cord-325712-9kbnyqt3 246 19 it -PRON- PRP cord-325712-9kbnyqt3 246 20 requires require VBZ cord-325712-9kbnyqt3 246 21 less less RBR cord-325712-9kbnyqt3 246 22 specialized specialized JJ cord-325712-9kbnyqt3 246 23 microscopes microscope NNS cord-325712-9kbnyqt3 246 24 and and CC cord-325712-9kbnyqt3 246 25 cameras camera NNS cord-325712-9kbnyqt3 246 26 than than IN cord-325712-9kbnyqt3 246 27 livecell livecell NNP cord-325712-9kbnyqt3 246 28 imaging imaging NN cord-325712-9kbnyqt3 246 29 . . . cord-325712-9kbnyqt3 247 1 For for IN cord-325712-9kbnyqt3 247 2 viruses virus NNS cord-325712-9kbnyqt3 247 3 that that WDT cord-325712-9kbnyqt3 247 4 are be VBP cord-325712-9kbnyqt3 247 5 internalized internalize VBN cord-325712-9kbnyqt3 247 6 , , , cord-325712-9kbnyqt3 247 7 live live JJ cord-325712-9kbnyqt3 247 8 - - HYPH cord-325712-9kbnyqt3 247 9 cell cell NN cord-325712-9kbnyqt3 247 10 fluorescent fluorescent NN cord-325712-9kbnyqt3 247 11 imaging imaging NN cord-325712-9kbnyqt3 247 12 can can MD cord-325712-9kbnyqt3 247 13 provide provide VB cord-325712-9kbnyqt3 247 14 insight insight NN cord-325712-9kbnyqt3 247 15 into into IN cord-325712-9kbnyqt3 247 16 how how WRB cord-325712-9kbnyqt3 247 17 viruses virus NNS cord-325712-9kbnyqt3 247 18 use use VBP cord-325712-9kbnyqt3 247 19 cellular cellular JJ cord-325712-9kbnyqt3 247 20 machinery machinery NN cord-325712-9kbnyqt3 247 21 , , , cord-325712-9kbnyqt3 247 22 such such JJ cord-325712-9kbnyqt3 247 23 as as IN cord-325712-9kbnyqt3 247 24 the the DT cord-325712-9kbnyqt3 247 25 cytoskeleton cytoskeleton NN cord-325712-9kbnyqt3 247 26 or or CC cord-325712-9kbnyqt3 247 27 microtubules microtubule NNS cord-325712-9kbnyqt3 247 28 , , , cord-325712-9kbnyqt3 247 29 to to TO cord-325712-9kbnyqt3 247 30 propel propel VB cord-325712-9kbnyqt3 247 31 their -PRON- PRP$ cord-325712-9kbnyqt3 247 32 movement movement NN cord-325712-9kbnyqt3 247 33 within within IN cord-325712-9kbnyqt3 247 34 the the DT cord-325712-9kbnyqt3 247 35 cell cell NN cord-325712-9kbnyqt3 247 36 . . . cord-325712-9kbnyqt3 248 1 One one CD cord-325712-9kbnyqt3 248 2 common common JJ cord-325712-9kbnyqt3 248 3 approach approach NN cord-325712-9kbnyqt3 248 4 to to IN cord-325712-9kbnyqt3 248 5 determining determine VBG cord-325712-9kbnyqt3 248 6 if if IN cord-325712-9kbnyqt3 248 7 cytoskeletal cytoskeletal JJ cord-325712-9kbnyqt3 248 8 elements element NNS cord-325712-9kbnyqt3 248 9 are be VBP cord-325712-9kbnyqt3 248 10 involved involve VBN cord-325712-9kbnyqt3 248 11 is be VBZ cord-325712-9kbnyqt3 248 12 to to TO cord-325712-9kbnyqt3 248 13 compare compare VB cord-325712-9kbnyqt3 248 14 the the DT cord-325712-9kbnyqt3 248 15 speed speed NN cord-325712-9kbnyqt3 248 16 and and CC cord-325712-9kbnyqt3 248 17 shape shape NN cord-325712-9kbnyqt3 248 18 of of IN cord-325712-9kbnyqt3 248 19 virion virion NN cord-325712-9kbnyqt3 248 20 trajectories trajectory NNS cord-325712-9kbnyqt3 248 21 in in IN cord-325712-9kbnyqt3 248 22 the the DT cord-325712-9kbnyqt3 248 23 presence presence NN cord-325712-9kbnyqt3 248 24 and and CC cord-325712-9kbnyqt3 248 25 absence absence NN cord-325712-9kbnyqt3 248 26 of of IN cord-325712-9kbnyqt3 248 27 cytoskeletal cytoskeletal JJ cord-325712-9kbnyqt3 248 28 inhibitors inhibitor NNS cord-325712-9kbnyqt3 248 29 such such JJ cord-325712-9kbnyqt3 248 30 as as IN cord-325712-9kbnyqt3 248 31 nocodazole nocodazole NNP cord-325712-9kbnyqt3 248 32 , , , cord-325712-9kbnyqt3 248 33 and and CC cord-325712-9kbnyqt3 248 34 cytochalasin cytochalasin NNP cord-325712-9kbnyqt3 248 35 D D NNP cord-325712-9kbnyqt3 248 36 [ [ -LRB- cord-325712-9kbnyqt3 248 37 114 114 CD cord-325712-9kbnyqt3 248 38 ] ] -RRB- cord-325712-9kbnyqt3 248 39 . . . cord-325712-9kbnyqt3 249 1 This this DT cord-325712-9kbnyqt3 249 2 strategy strategy NN cord-325712-9kbnyqt3 249 3 has have VBZ cord-325712-9kbnyqt3 249 4 been be VBN cord-325712-9kbnyqt3 249 5 employed employ VBN cord-325712-9kbnyqt3 249 6 to to TO cord-325712-9kbnyqt3 249 7 determine determine VB cord-325712-9kbnyqt3 249 8 that that IN cord-325712-9kbnyqt3 249 9 reovirus reovirus NNP cord-325712-9kbnyqt3 249 10 movement movement NN cord-325712-9kbnyqt3 249 11 after after IN cord-325712-9kbnyqt3 249 12 endocytosis endocytosis NN cord-325712-9kbnyqt3 249 13 is be VBZ cord-325712-9kbnyqt3 249 14 microtubule microtubule NN cord-325712-9kbnyqt3 249 15 - - HYPH cord-325712-9kbnyqt3 249 16 directed direct VBN cord-325712-9kbnyqt3 249 17 [ [ -LRB- cord-325712-9kbnyqt3 249 18 114 114 CD cord-325712-9kbnyqt3 249 19 ] ] -RRB- cord-325712-9kbnyqt3 249 20 . . . cord-325712-9kbnyqt3 250 1 Microtubules microtubule NNS cord-325712-9kbnyqt3 250 2 are be VBP cord-325712-9kbnyqt3 250 3 involved involve VBN cord-325712-9kbnyqt3 250 4 in in IN cord-325712-9kbnyqt3 250 5 the the DT cord-325712-9kbnyqt3 250 6 cytosolic cytosolic JJ cord-325712-9kbnyqt3 250 7 movement movement NN cord-325712-9kbnyqt3 250 8 of of IN cord-325712-9kbnyqt3 250 9 Adeno Adeno NNP cord-325712-9kbnyqt3 250 10 - - HYPH cord-325712-9kbnyqt3 250 11 associated associate VBN cord-325712-9kbnyqt3 250 12 virus virus NN cord-325712-9kbnyqt3 250 13 type type NN cord-325712-9kbnyqt3 250 14 2 2 CD cord-325712-9kbnyqt3 250 15 [ [ -LRB- cord-325712-9kbnyqt3 250 16 115 115 CD cord-325712-9kbnyqt3 250 17 ] ] -RRB- cord-325712-9kbnyqt3 250 18 , , , cord-325712-9kbnyqt3 250 19 HIV HIV NNP cord-325712-9kbnyqt3 250 20 [ [ -LRB- cord-325712-9kbnyqt3 250 21 30 30 CD cord-325712-9kbnyqt3 250 22 , , , cord-325712-9kbnyqt3 250 23 116 116 CD cord-325712-9kbnyqt3 250 24 ] ] -RRB- cord-325712-9kbnyqt3 250 25 infectious infectious JJ cord-325712-9kbnyqt3 250 26 hematopoietic hematopoietic JJ cord-325712-9kbnyqt3 250 27 necrosis necrosis NN cord-325712-9kbnyqt3 250 28 virus virus NN cord-325712-9kbnyqt3 250 29 [ [ -LRB- cord-325712-9kbnyqt3 250 30 101 101 CD cord-325712-9kbnyqt3 250 31 ] ] -RRB- cord-325712-9kbnyqt3 250 32 , , , cord-325712-9kbnyqt3 250 33 rabies rabies NN cord-325712-9kbnyqt3 250 34 virus virus NN cord-325712-9kbnyqt3 250 35 [ [ -LRB- cord-325712-9kbnyqt3 250 36 74 74 CD cord-325712-9kbnyqt3 250 37 ] ] -RRB- cord-325712-9kbnyqt3 250 38 , , . cord-325712-9kbnyqt3 251 1 In in IN cord-325712-9kbnyqt3 251 2 contrast contrast NN cord-325712-9kbnyqt3 251 3 , , , cord-325712-9kbnyqt3 251 4 polio polio NN cord-325712-9kbnyqt3 251 5 movement movement NN cord-325712-9kbnyqt3 251 6 inside inside IN cord-325712-9kbnyqt3 251 7 cells cell NNS cord-325712-9kbnyqt3 251 8 is be VBZ cord-325712-9kbnyqt3 251 9 actin actin JJ cord-325712-9kbnyqt3 251 10 dependent dependent JJ cord-325712-9kbnyqt3 251 11 , , , cord-325712-9kbnyqt3 251 12 but but CC cord-325712-9kbnyqt3 251 13 microtubule microtubule JJ cord-325712-9kbnyqt3 251 14 independent independent JJ cord-325712-9kbnyqt3 251 15 [ [ -LRB- cord-325712-9kbnyqt3 251 16 117 117 CD cord-325712-9kbnyqt3 251 17 ] ] -RRB- cord-325712-9kbnyqt3 251 18 . . . cord-325712-9kbnyqt3 252 1 Adenovirus Adenovirus NNP cord-325712-9kbnyqt3 252 2 interacts interact VBZ cord-325712-9kbnyqt3 252 3 with with IN cord-325712-9kbnyqt3 252 4 minus minus JJ cord-325712-9kbnyqt3 252 5 - - HYPH cord-325712-9kbnyqt3 252 6 end end NN cord-325712-9kbnyqt3 252 7 dynein dynein NN cord-325712-9kbnyqt3 252 8 and and CC cord-325712-9kbnyqt3 252 9 a a DT cord-325712-9kbnyqt3 252 10 plus plus NN cord-325712-9kbnyqt3 252 11 - - HYPH cord-325712-9kbnyqt3 252 12 end end NN cord-325712-9kbnyqt3 252 13 directed direct VBN cord-325712-9kbnyqt3 252 14 factor factor NN cord-325712-9kbnyqt3 252 15 to to IN cord-325712-9kbnyqt3 252 16 traffic traffic NN cord-325712-9kbnyqt3 252 17 along along IN cord-325712-9kbnyqt3 252 18 cytoplasmic cytoplasmic JJ cord-325712-9kbnyqt3 252 19 microtubules microtubule NNS cord-325712-9kbnyqt3 252 20 [ [ -LRB- cord-325712-9kbnyqt3 252 21 118 118 CD cord-325712-9kbnyqt3 252 22 ] ] -RRB- cord-325712-9kbnyqt3 252 23 . . . cord-325712-9kbnyqt3 253 1 Influenza influenza NN cord-325712-9kbnyqt3 253 2 in in IN cord-325712-9kbnyqt3 253 3 endosomes endosome NNS cord-325712-9kbnyqt3 253 4 undergoes undergo VBZ cord-325712-9kbnyqt3 253 5 unidirectional unidirectional JJ cord-325712-9kbnyqt3 253 6 dynein dynein NN cord-325712-9kbnyqt3 253 7 - - HYPH cord-325712-9kbnyqt3 253 8 directed direct VBN cord-325712-9kbnyqt3 253 9 translocation translocation NN cord-325712-9kbnyqt3 253 10 to to IN cord-325712-9kbnyqt3 253 11 the the DT cord-325712-9kbnyqt3 253 12 perinuclear perinuclear NNP cord-325712-9kbnyqt3 253 13 region region NN cord-325712-9kbnyqt3 253 14 followed follow VBN cord-325712-9kbnyqt3 253 15 by by IN cord-325712-9kbnyqt3 253 16 intermittent intermittent JJ cord-325712-9kbnyqt3 253 17 back back NN cord-325712-9kbnyqt3 253 18 - - HYPH cord-325712-9kbnyqt3 253 19 and and CC cord-325712-9kbnyqt3 253 20 - - HYPH cord-325712-9kbnyqt3 253 21 forth forth RB cord-325712-9kbnyqt3 253 22 microtubule microtubule NN cord-325712-9kbnyqt3 253 23 - - HYPH cord-325712-9kbnyqt3 253 24 dependent dependent JJ cord-325712-9kbnyqt3 253 25 motion motion NN cord-325712-9kbnyqt3 253 26 within within IN cord-325712-9kbnyqt3 253 27 the the DT cord-325712-9kbnyqt3 253 28 perinuclear perinuclear NNP cord-325712-9kbnyqt3 253 29 region region NN cord-325712-9kbnyqt3 253 30 prior prior RB cord-325712-9kbnyqt3 253 31 to to IN cord-325712-9kbnyqt3 253 32 virion virion NN cord-325712-9kbnyqt3 253 33 fusion fusion NN cord-325712-9kbnyqt3 253 34 with with IN cord-325712-9kbnyqt3 253 35 endosomes endosome NNS cord-325712-9kbnyqt3 253 36 [ [ -LRB- cord-325712-9kbnyqt3 253 37 10 10 CD cord-325712-9kbnyqt3 253 38 ] ] -RRB- cord-325712-9kbnyqt3 253 39 . . . cord-325712-9kbnyqt3 254 1 In in IN cord-325712-9kbnyqt3 254 2 addition addition NN cord-325712-9kbnyqt3 254 3 to to IN cord-325712-9kbnyqt3 254 4 investigating investigate VBG cord-325712-9kbnyqt3 254 5 movement movement NN cord-325712-9kbnyqt3 254 6 towards towards IN cord-325712-9kbnyqt3 254 7 the the DT cord-325712-9kbnyqt3 254 8 nucleus nucleus NN cord-325712-9kbnyqt3 254 9 , , , cord-325712-9kbnyqt3 254 10 live live JJ cord-325712-9kbnyqt3 254 11 - - HYPH cord-325712-9kbnyqt3 254 12 cell cell NN cord-325712-9kbnyqt3 254 13 single single JJ cord-325712-9kbnyqt3 254 14 virion virion NN cord-325712-9kbnyqt3 254 15 tracking tracking NN cord-325712-9kbnyqt3 254 16 has have VBZ cord-325712-9kbnyqt3 254 17 been be VBN cord-325712-9kbnyqt3 254 18 used use VBN cord-325712-9kbnyqt3 254 19 to to TO cord-325712-9kbnyqt3 254 20 monitor monitor VB cord-325712-9kbnyqt3 254 21 movement movement NN cord-325712-9kbnyqt3 254 22 within within IN cord-325712-9kbnyqt3 254 23 the the DT cord-325712-9kbnyqt3 254 24 nuclear nuclear JJ cord-325712-9kbnyqt3 254 25 region region NN cord-325712-9kbnyqt3 254 26 . . . cord-325712-9kbnyqt3 255 1 Adenovirus Adenovirus NNP cord-325712-9kbnyqt3 255 2 utilizes utilize VBZ cord-325712-9kbnyqt3 255 3 microtubules microtubule NNS cord-325712-9kbnyqt3 255 4 for for IN cord-325712-9kbnyqt3 255 5 movement movement NN cord-325712-9kbnyqt3 255 6 within within IN cord-325712-9kbnyqt3 255 7 the the DT cord-325712-9kbnyqt3 255 8 cell cell NN cord-325712-9kbnyqt3 255 9 , , , cord-325712-9kbnyqt3 255 10 but but CC cord-325712-9kbnyqt3 255 11 detaches detach VBZ cord-325712-9kbnyqt3 255 12 from from IN cord-325712-9kbnyqt3 255 13 them -PRON- PRP cord-325712-9kbnyqt3 255 14 when when WRB cord-325712-9kbnyqt3 255 15 the the DT cord-325712-9kbnyqt3 255 16 virions virion NNS cord-325712-9kbnyqt3 255 17 reach reach VBP cord-325712-9kbnyqt3 255 18 close close JJ cord-325712-9kbnyqt3 255 19 proximity proximity NN cord-325712-9kbnyqt3 255 20 to to IN cord-325712-9kbnyqt3 255 21 the the DT cord-325712-9kbnyqt3 255 22 nucleus nucleus NN cord-325712-9kbnyqt3 255 23 [ [ -LRB- cord-325712-9kbnyqt3 255 24 119 119 CD cord-325712-9kbnyqt3 255 25 ] ] -RRB- cord-325712-9kbnyqt3 255 26 . . . cord-325712-9kbnyqt3 256 1 HIV HIV NNP cord-325712-9kbnyqt3 256 2 cores core NNS cord-325712-9kbnyqt3 256 3 move move VBP cord-325712-9kbnyqt3 256 4 toward toward IN cord-325712-9kbnyqt3 256 5 the the DT cord-325712-9kbnyqt3 256 6 nucleus nucleus NN cord-325712-9kbnyqt3 256 7 with with IN cord-325712-9kbnyqt3 256 8 a a DT cord-325712-9kbnyqt3 256 9 microtuble microtuble NN cord-325712-9kbnyqt3 256 10 - - : cord-325712-9kbnyqt3 256 11 and and CC cord-325712-9kbnyqt3 256 12 actin actin NN cord-325712-9kbnyqt3 256 13 - - HYPH cord-325712-9kbnyqt3 256 14 dependent dependent JJ cord-325712-9kbnyqt3 256 15 motion motion NN cord-325712-9kbnyqt3 256 16 ; ; : cord-325712-9kbnyqt3 256 17 within within IN cord-325712-9kbnyqt3 256 18 the the DT cord-325712-9kbnyqt3 256 19 nucleus nucleus NN cord-325712-9kbnyqt3 256 20 , , , cord-325712-9kbnyqt3 256 21 the the DT cord-325712-9kbnyqt3 256 22 motion motion NN cord-325712-9kbnyqt3 256 23 is be VBZ cord-325712-9kbnyqt3 256 24 slow slow JJ cord-325712-9kbnyqt3 256 25 and and CC cord-325712-9kbnyqt3 256 26 diffuse diffuse JJ cord-325712-9kbnyqt3 256 27 [ [ -LRB- cord-325712-9kbnyqt3 256 28 100 100 CD cord-325712-9kbnyqt3 256 29 , , , cord-325712-9kbnyqt3 256 30 116 116 CD cord-325712-9kbnyqt3 256 31 , , , cord-325712-9kbnyqt3 256 32 120 120 CD cord-325712-9kbnyqt3 256 33 ] ] -RRB- cord-325712-9kbnyqt3 256 34 . . . cord-325712-9kbnyqt3 257 1 HIV HIV NNP cord-325712-9kbnyqt3 257 2 RNA RNA NNP cord-325712-9kbnyqt3 257 3 alone alone RB cord-325712-9kbnyqt3 257 4 moves move VBZ cord-325712-9kbnyqt3 257 5 through through IN cord-325712-9kbnyqt3 257 6 the the DT cord-325712-9kbnyqt3 257 7 cytoplasm cytoplasm NN cord-325712-9kbnyqt3 257 8 by by IN cord-325712-9kbnyqt3 257 9 diffusion diffusion NN cord-325712-9kbnyqt3 257 10 [ [ -LRB- cord-325712-9kbnyqt3 257 11 121 121 CD cord-325712-9kbnyqt3 257 12 ] ] -RRB- cord-325712-9kbnyqt3 257 13 . . . cord-325712-9kbnyqt3 258 1 After after IN cord-325712-9kbnyqt3 258 2 reaching reach VBG cord-325712-9kbnyqt3 258 3 the the DT cord-325712-9kbnyqt3 258 4 nucleus nucleus NN cord-325712-9kbnyqt3 258 5 , , , cord-325712-9kbnyqt3 258 6 HIV HIV NNP cord-325712-9kbnyqt3 258 7 pre pre VBD cord-325712-9kbnyqt3 258 8 - - VB cord-325712-9kbnyqt3 258 9 integration integration JJ cord-325712-9kbnyqt3 258 10 complexes complex NNS cord-325712-9kbnyqt3 258 11 target target VBP cord-325712-9kbnyqt3 258 12 areas area NNS cord-325712-9kbnyqt3 258 13 of of IN cord-325712-9kbnyqt3 258 14 decondensed decondense VBN cord-325712-9kbnyqt3 258 15 chromatin chromatin NN cord-325712-9kbnyqt3 258 16 [ [ -LRB- cord-325712-9kbnyqt3 258 17 122 122 CD cord-325712-9kbnyqt3 258 18 ] ] -RRB- cord-325712-9kbnyqt3 258 19 . . . cord-325712-9kbnyqt3 259 1 For for IN cord-325712-9kbnyqt3 259 2 influenza influenza NN cord-325712-9kbnyqt3 259 3 , , , cord-325712-9kbnyqt3 259 4 genes gene NNS cord-325712-9kbnyqt3 259 5 are be VBP cord-325712-9kbnyqt3 259 6 transported transport VBN cord-325712-9kbnyqt3 259 7 to to IN cord-325712-9kbnyqt3 259 8 and and CC cord-325712-9kbnyqt3 259 9 within within IN cord-325712-9kbnyqt3 259 10 the the DT cord-325712-9kbnyqt3 259 11 nucleus nucleus NN cord-325712-9kbnyqt3 259 12 by by IN cord-325712-9kbnyqt3 259 13 diffusion diffusion NN cord-325712-9kbnyqt3 259 14 [ [ -LRB- cord-325712-9kbnyqt3 259 15 123 123 CD cord-325712-9kbnyqt3 259 16 ] ] -RRB- cord-325712-9kbnyqt3 259 17 . . . cord-325712-9kbnyqt3 260 1 Intracellular Intracellular NNP cord-325712-9kbnyqt3 260 2 movement movement NN cord-325712-9kbnyqt3 260 3 of of IN cord-325712-9kbnyqt3 260 4 virions virion NNS cord-325712-9kbnyqt3 260 5 is be VBZ cord-325712-9kbnyqt3 260 6 not not RB cord-325712-9kbnyqt3 260 7 necessarily necessarily RB cord-325712-9kbnyqt3 260 8 mediated mediate VBN cord-325712-9kbnyqt3 260 9 by by IN cord-325712-9kbnyqt3 260 10 spike spike NN cord-325712-9kbnyqt3 260 11 or or CC cord-325712-9kbnyqt3 260 12 capsid capsid NN cord-325712-9kbnyqt3 260 13 proteins protein NNS cord-325712-9kbnyqt3 260 14 alone alone RB cord-325712-9kbnyqt3 260 15 ; ; : cord-325712-9kbnyqt3 260 16 for for IN cord-325712-9kbnyqt3 260 17 herpes herpes NN cord-325712-9kbnyqt3 260 18 simplex simplex NNP cord-325712-9kbnyqt3 260 19 virus virus NN cord-325712-9kbnyqt3 260 20 , , , cord-325712-9kbnyqt3 260 21 the the DT cord-325712-9kbnyqt3 260 22 inner inner JJ cord-325712-9kbnyqt3 260 23 tegument tegument NN cord-325712-9kbnyqt3 260 24 proteins protein NNS cord-325712-9kbnyqt3 260 25 promote promote VBP cord-325712-9kbnyqt3 260 26 movement movement NN cord-325712-9kbnyqt3 260 27 along along IN cord-325712-9kbnyqt3 260 28 microtubules microtubule NNS cord-325712-9kbnyqt3 260 29 and and CC cord-325712-9kbnyqt3 260 30 are be VBP cord-325712-9kbnyqt3 260 31 necessary necessary JJ cord-325712-9kbnyqt3 260 32 for for IN cord-325712-9kbnyqt3 260 33 movement movement NN cord-325712-9kbnyqt3 260 34 away away RB cord-325712-9kbnyqt3 260 35 from from IN cord-325712-9kbnyqt3 260 36 the the DT cord-325712-9kbnyqt3 260 37 cell cell NN cord-325712-9kbnyqt3 260 38 body body NN cord-325712-9kbnyqt3 260 39 along along IN cord-325712-9kbnyqt3 260 40 axons axon NNS cord-325712-9kbnyqt3 260 41 [ [ -LRB- cord-325712-9kbnyqt3 260 42 124 124 CD cord-325712-9kbnyqt3 260 43 ] ] -RRB- cord-325712-9kbnyqt3 260 44 [ [ -LRB- cord-325712-9kbnyqt3 260 45 125 125 CD cord-325712-9kbnyqt3 260 46 ] ] -RRB- cord-325712-9kbnyqt3 260 47 [ [ -LRB- cord-325712-9kbnyqt3 260 48 126 126 CD cord-325712-9kbnyqt3 260 49 ] ] -RRB- cord-325712-9kbnyqt3 260 50 . . . cord-325712-9kbnyqt3 261 1 An an DT cord-325712-9kbnyqt3 261 2 alternative alternative JJ cord-325712-9kbnyqt3 261 3 method method NN cord-325712-9kbnyqt3 261 4 is be VBZ cord-325712-9kbnyqt3 261 5 to to TO cord-325712-9kbnyqt3 261 6 use use VB cord-325712-9kbnyqt3 261 7 immunofluorescence immunofluorescence NN cord-325712-9kbnyqt3 261 8 assays assay NNS cord-325712-9kbnyqt3 261 9 of of IN cord-325712-9kbnyqt3 261 10 fixed fix VBN cord-325712-9kbnyqt3 261 11 cells cell NNS cord-325712-9kbnyqt3 261 12 to to TO cord-325712-9kbnyqt3 261 13 obtain obtain VB cord-325712-9kbnyqt3 261 14 snapshots snapshot NNS cord-325712-9kbnyqt3 261 15 of of IN cord-325712-9kbnyqt3 261 16 intracellular intracellular JJ cord-325712-9kbnyqt3 261 17 virion virion NN cord-325712-9kbnyqt3 261 18 trafficking trafficking NN cord-325712-9kbnyqt3 261 19 , , , cord-325712-9kbnyqt3 261 20 including include VBG cord-325712-9kbnyqt3 261 21 what what WDT cord-325712-9kbnyqt3 261 22 cytoskeletal cytoskeletal JJ cord-325712-9kbnyqt3 261 23 components component NNS cord-325712-9kbnyqt3 261 24 are be VBP cord-325712-9kbnyqt3 261 25 involved involve VBN cord-325712-9kbnyqt3 261 26 [ [ -LRB- cord-325712-9kbnyqt3 261 27 127 127 CD cord-325712-9kbnyqt3 261 28 , , , cord-325712-9kbnyqt3 261 29 128 128 CD cord-325712-9kbnyqt3 261 30 ] ] -RRB- cord-325712-9kbnyqt3 261 31 . . . cord-325712-9kbnyqt3 262 1 These these DT cord-325712-9kbnyqt3 262 2 do do VBP cord-325712-9kbnyqt3 262 3 not not RB cord-325712-9kbnyqt3 262 4 allow allow VB cord-325712-9kbnyqt3 262 5 for for IN cord-325712-9kbnyqt3 262 6 the the DT cord-325712-9kbnyqt3 262 7 tracking tracking NN cord-325712-9kbnyqt3 262 8 of of IN cord-325712-9kbnyqt3 262 9 individual individual JJ cord-325712-9kbnyqt3 262 10 virion virion NN cord-325712-9kbnyqt3 262 11 trajectories trajectory NNS cord-325712-9kbnyqt3 262 12 and and CC cord-325712-9kbnyqt3 262 13 are be VBP cord-325712-9kbnyqt3 262 14 more more RBR cord-325712-9kbnyqt3 262 15 limited limited JJ cord-325712-9kbnyqt3 262 16 in in IN cord-325712-9kbnyqt3 262 17 temporal temporal JJ cord-325712-9kbnyqt3 262 18 resolution resolution NN cord-325712-9kbnyqt3 262 19 than than IN cord-325712-9kbnyqt3 262 20 live live JJ cord-325712-9kbnyqt3 262 21 cell cell NN cord-325712-9kbnyqt3 262 22 virion virion NN cord-325712-9kbnyqt3 262 23 tracking tracking NN cord-325712-9kbnyqt3 262 24 , , , cord-325712-9kbnyqt3 262 25 but but CC cord-325712-9kbnyqt3 262 26 require require VB cord-325712-9kbnyqt3 262 27 less less RBR cord-325712-9kbnyqt3 262 28 specialized specialized JJ cord-325712-9kbnyqt3 262 29 equipment equipment NN cord-325712-9kbnyqt3 262 30 . . . cord-325712-9kbnyqt3 263 1 Membrane membrane NN cord-325712-9kbnyqt3 263 2 enveloped envelop VBD cord-325712-9kbnyqt3 263 3 viruses virus NNS cord-325712-9kbnyqt3 263 4 must must MD cord-325712-9kbnyqt3 263 5 fuse fuse VB cord-325712-9kbnyqt3 263 6 their -PRON- PRP$ cord-325712-9kbnyqt3 263 7 membrane membrane NN cord-325712-9kbnyqt3 263 8 with with IN cord-325712-9kbnyqt3 263 9 the the DT cord-325712-9kbnyqt3 263 10 host host NN cord-325712-9kbnyqt3 263 11 membrane membrane NN cord-325712-9kbnyqt3 263 12 to to TO cord-325712-9kbnyqt3 263 13 deliver deliver VB cord-325712-9kbnyqt3 263 14 their -PRON- PRP$ cord-325712-9kbnyqt3 263 15 genome genome NN cord-325712-9kbnyqt3 263 16 to to IN cord-325712-9kbnyqt3 263 17 the the DT cord-325712-9kbnyqt3 263 18 cytosol cytosol NN cord-325712-9kbnyqt3 263 19 for for IN cord-325712-9kbnyqt3 263 20 replication replication NN cord-325712-9kbnyqt3 263 21 . . . cord-325712-9kbnyqt3 264 1 Fusion fusion NN cord-325712-9kbnyqt3 264 2 can can MD cord-325712-9kbnyqt3 264 3 occur occur VB cord-325712-9kbnyqt3 264 4 either either CC cord-325712-9kbnyqt3 264 5 at at IN cord-325712-9kbnyqt3 264 6 the the DT cord-325712-9kbnyqt3 264 7 plasma plasma NN cord-325712-9kbnyqt3 264 8 membrane membrane NN cord-325712-9kbnyqt3 264 9 surface surface NN cord-325712-9kbnyqt3 264 10 or or CC cord-325712-9kbnyqt3 264 11 in in IN cord-325712-9kbnyqt3 264 12 endosomes endosome NNS cord-325712-9kbnyqt3 264 13 after after IN cord-325712-9kbnyqt3 264 14 the the DT cord-325712-9kbnyqt3 264 15 virion virion NN cord-325712-9kbnyqt3 264 16 is be VBZ cord-325712-9kbnyqt3 264 17 internalized internalize VBN cord-325712-9kbnyqt3 264 18 . . . cord-325712-9kbnyqt3 265 1 Fusion fusion NN cord-325712-9kbnyqt3 265 2 can can MD cord-325712-9kbnyqt3 265 3 be be VB cord-325712-9kbnyqt3 265 4 monitored monitor VBN cord-325712-9kbnyqt3 265 5 in in IN cord-325712-9kbnyqt3 265 6 both both DT cord-325712-9kbnyqt3 265 7 live live JJ cord-325712-9kbnyqt3 265 8 cells cell NNS cord-325712-9kbnyqt3 265 9 and and CC cord-325712-9kbnyqt3 265 10 in in IN cord-325712-9kbnyqt3 265 11 in in FW cord-325712-9kbnyqt3 265 12 vitro vitro FW cord-325712-9kbnyqt3 265 13 platforms platform NNS cord-325712-9kbnyqt3 265 14 . . . cord-325712-9kbnyqt3 266 1 Each each DT cord-325712-9kbnyqt3 266 2 approach approach NN cord-325712-9kbnyqt3 266 3 has have VBZ cord-325712-9kbnyqt3 266 4 advantages advantage NNS cord-325712-9kbnyqt3 266 5 and and CC cord-325712-9kbnyqt3 266 6 disadvantages disadvantage NNS cord-325712-9kbnyqt3 266 7 , , , cord-325712-9kbnyqt3 266 8 and and CC cord-325712-9kbnyqt3 266 9 some some DT cord-325712-9kbnyqt3 266 10 examples example NNS cord-325712-9kbnyqt3 266 11 of of IN cord-325712-9kbnyqt3 266 12 how how WRB cord-325712-9kbnyqt3 266 13 these these DT cord-325712-9kbnyqt3 266 14 experiments experiment NNS cord-325712-9kbnyqt3 266 15 are be VBP cord-325712-9kbnyqt3 266 16 conducted conduct VBN cord-325712-9kbnyqt3 266 17 follow follow VBP cord-325712-9kbnyqt3 266 18 next next RB cord-325712-9kbnyqt3 266 19 . . . cord-325712-9kbnyqt3 267 1 Viral viral JJ cord-325712-9kbnyqt3 267 2 fusion fusion NN cord-325712-9kbnyqt3 267 3 at at IN cord-325712-9kbnyqt3 267 4 the the DT cord-325712-9kbnyqt3 267 5 plasma plasma NN cord-325712-9kbnyqt3 267 6 membrane membrane NN cord-325712-9kbnyqt3 267 7 can can MD cord-325712-9kbnyqt3 267 8 be be VB cord-325712-9kbnyqt3 267 9 differentiated differentiate VBN cord-325712-9kbnyqt3 267 10 from from IN cord-325712-9kbnyqt3 267 11 fusion fusion NN cord-325712-9kbnyqt3 267 12 within within IN cord-325712-9kbnyqt3 267 13 endosomes endosome NNS cord-325712-9kbnyqt3 267 14 in in IN cord-325712-9kbnyqt3 267 15 live live JJ cord-325712-9kbnyqt3 267 16 cells cell NNS cord-325712-9kbnyqt3 267 17 . . . cord-325712-9kbnyqt3 268 1 To to TO cord-325712-9kbnyqt3 268 2 do do VB cord-325712-9kbnyqt3 268 3 so so RB cord-325712-9kbnyqt3 268 4 , , , cord-325712-9kbnyqt3 268 5 the the DT cord-325712-9kbnyqt3 268 6 viral viral JJ cord-325712-9kbnyqt3 268 7 contents content NNS cord-325712-9kbnyqt3 268 8 can can MD cord-325712-9kbnyqt3 268 9 be be VB cord-325712-9kbnyqt3 268 10 labeled label VBN cord-325712-9kbnyqt3 268 11 with with IN cord-325712-9kbnyqt3 268 12 a a DT cord-325712-9kbnyqt3 268 13 diffusible diffusible JJ cord-325712-9kbnyqt3 268 14 content content NN cord-325712-9kbnyqt3 268 15 marker marker NN cord-325712-9kbnyqt3 268 16 while while IN cord-325712-9kbnyqt3 268 17 the the DT cord-325712-9kbnyqt3 268 18 envelope envelope NN cord-325712-9kbnyqt3 268 19 is be VBZ cord-325712-9kbnyqt3 268 20 labeled label VBN cord-325712-9kbnyqt3 268 21 with with IN cord-325712-9kbnyqt3 268 22 an an DT cord-325712-9kbnyqt3 268 23 acid acid NN cord-325712-9kbnyqt3 268 24 - - HYPH cord-325712-9kbnyqt3 268 25 stable stable JJ cord-325712-9kbnyqt3 268 26 lipophilic lipophilic JJ cord-325712-9kbnyqt3 268 27 dye dye NN cord-325712-9kbnyqt3 268 28 . . . cord-325712-9kbnyqt3 269 1 If if IN cord-325712-9kbnyqt3 269 2 fusion fusion NN cord-325712-9kbnyqt3 269 3 occurs occur VBZ cord-325712-9kbnyqt3 269 4 at at IN cord-325712-9kbnyqt3 269 5 the the DT cord-325712-9kbnyqt3 269 6 plasma plasma NN cord-325712-9kbnyqt3 269 7 membrane membrane NN cord-325712-9kbnyqt3 269 8 , , , cord-325712-9kbnyqt3 269 9 both both DT cord-325712-9kbnyqt3 269 10 fluorescent fluorescent JJ cord-325712-9kbnyqt3 269 11 markers marker NNS cord-325712-9kbnyqt3 269 12 will will MD cord-325712-9kbnyqt3 269 13 seem seem VB cord-325712-9kbnyqt3 269 14 to to TO cord-325712-9kbnyqt3 269 15 disappear disappear VB cord-325712-9kbnyqt3 269 16 because because IN cord-325712-9kbnyqt3 269 17 they -PRON- PRP cord-325712-9kbnyqt3 269 18 will will MD cord-325712-9kbnyqt3 269 19 be be VB cord-325712-9kbnyqt3 269 20 diluted dilute VBN cord-325712-9kbnyqt3 269 21 into into IN cord-325712-9kbnyqt3 269 22 the the DT cord-325712-9kbnyqt3 269 23 plasma plasma NN cord-325712-9kbnyqt3 269 24 membrane membrane NN cord-325712-9kbnyqt3 269 25 and and CC cord-325712-9kbnyqt3 269 26 cytosol cytosol NN cord-325712-9kbnyqt3 269 27 . . . cord-325712-9kbnyqt3 270 1 If if IN cord-325712-9kbnyqt3 270 2 fusion fusion NN cord-325712-9kbnyqt3 270 3 occurs occur VBZ cord-325712-9kbnyqt3 270 4 within within IN cord-325712-9kbnyqt3 270 5 an an DT cord-325712-9kbnyqt3 270 6 endosome endosome NN cord-325712-9kbnyqt3 270 7 , , , cord-325712-9kbnyqt3 270 8 the the DT cord-325712-9kbnyqt3 270 9 viral viral JJ cord-325712-9kbnyqt3 270 10 content content NN cord-325712-9kbnyqt3 270 11 marker marker NN cord-325712-9kbnyqt3 270 12 will will MD cord-325712-9kbnyqt3 270 13 disappear disappear VB cord-325712-9kbnyqt3 270 14 as as IN cord-325712-9kbnyqt3 270 15 it -PRON- PRP cord-325712-9kbnyqt3 270 16 is be VBZ cord-325712-9kbnyqt3 270 17 released release VBN cord-325712-9kbnyqt3 270 18 into into IN cord-325712-9kbnyqt3 270 19 the the DT cord-325712-9kbnyqt3 270 20 cytosol cytosol NN cord-325712-9kbnyqt3 270 21 and and CC cord-325712-9kbnyqt3 270 22 diluted dilute VBN cord-325712-9kbnyqt3 270 23 , , , cord-325712-9kbnyqt3 270 24 but but CC cord-325712-9kbnyqt3 270 25 the the DT cord-325712-9kbnyqt3 270 26 lipid lipid NN cord-325712-9kbnyqt3 270 27 marker marker NN cord-325712-9kbnyqt3 270 28 will will MD cord-325712-9kbnyqt3 270 29 continue continue VB cord-325712-9kbnyqt3 270 30 to to TO cord-325712-9kbnyqt3 270 31 appear appear VB cord-325712-9kbnyqt3 270 32 bright bright JJ cord-325712-9kbnyqt3 270 33 as as IN cord-325712-9kbnyqt3 270 34 the the DT cord-325712-9kbnyqt3 270 35 dye dye NN cord-325712-9kbnyqt3 270 36 mixes mix VBZ cord-325712-9kbnyqt3 270 37 into into IN cord-325712-9kbnyqt3 270 38 the the DT cord-325712-9kbnyqt3 270 39 relatively relatively RB cord-325712-9kbnyqt3 270 40 small small JJ cord-325712-9kbnyqt3 270 41 endosomal endosomal NNP cord-325712-9kbnyqt3 270 42 membrane membrane NN cord-325712-9kbnyqt3 270 43 [ [ -LRB- cord-325712-9kbnyqt3 270 44 129 129 CD cord-325712-9kbnyqt3 270 45 ] ] -RRB- cord-325712-9kbnyqt3 270 46 . . . cord-325712-9kbnyqt3 271 1 This this DT cord-325712-9kbnyqt3 271 2 approach approach NN cord-325712-9kbnyqt3 271 3 has have VBZ cord-325712-9kbnyqt3 271 4 been be VBN cord-325712-9kbnyqt3 271 5 used use VBN cord-325712-9kbnyqt3 271 6 to to TO cord-325712-9kbnyqt3 271 7 show show VB cord-325712-9kbnyqt3 271 8 that that IN cord-325712-9kbnyqt3 271 9 HIV HIV NNP cord-325712-9kbnyqt3 271 10 can can MD cord-325712-9kbnyqt3 271 11 undergo undergo VB cord-325712-9kbnyqt3 271 12 full full JJ cord-325712-9kbnyqt3 271 13 fusion fusion NN cord-325712-9kbnyqt3 271 14 inside inside IN cord-325712-9kbnyqt3 271 15 endosomes endosome NNS cord-325712-9kbnyqt3 271 16 while while IN cord-325712-9kbnyqt3 271 17 fusion fusion NN cord-325712-9kbnyqt3 271 18 at at IN cord-325712-9kbnyqt3 271 19 plasma plasma NN cord-325712-9kbnyqt3 271 20 membrane membrane NN cord-325712-9kbnyqt3 271 21 is be VBZ cord-325712-9kbnyqt3 271 22 halted halt VBN cord-325712-9kbnyqt3 271 23 at at IN cord-325712-9kbnyqt3 271 24 the the DT cord-325712-9kbnyqt3 271 25 lipid lipid NN cord-325712-9kbnyqt3 271 26 mixing mix VBG cord-325712-9kbnyqt3 271 27 step step NN cord-325712-9kbnyqt3 271 28 . . . cord-325712-9kbnyqt3 272 1 However however RB cord-325712-9kbnyqt3 272 2 , , , cord-325712-9kbnyqt3 272 3 this this DT cord-325712-9kbnyqt3 272 4 may may MD cord-325712-9kbnyqt3 272 5 be be VB cord-325712-9kbnyqt3 272 6 cell cell NN cord-325712-9kbnyqt3 272 7 - - HYPH cord-325712-9kbnyqt3 272 8 type type NN cord-325712-9kbnyqt3 272 9 dependent dependent JJ cord-325712-9kbnyqt3 272 10 ; ; : cord-325712-9kbnyqt3 272 11 HIV HIV NNP cord-325712-9kbnyqt3 272 12 content content NN cord-325712-9kbnyqt3 272 13 release release NN cord-325712-9kbnyqt3 272 14 from from IN cord-325712-9kbnyqt3 272 15 plasma plasma NN cord-325712-9kbnyqt3 272 16 membrane membrane NN cord-325712-9kbnyqt3 272 17 fusion fusion NN cord-325712-9kbnyqt3 272 18 was be VBD cord-325712-9kbnyqt3 272 19 observed observe VBN cord-325712-9kbnyqt3 272 20 for for IN cord-325712-9kbnyqt3 272 21 U87 U87 NNP cord-325712-9kbnyqt3 272 22 cells cell NNS cord-325712-9kbnyqt3 272 23 but but CC cord-325712-9kbnyqt3 272 24 not not RB cord-325712-9kbnyqt3 272 25 JC5.3 jc5.3 NN cord-325712-9kbnyqt3 272 26 or or CC cord-325712-9kbnyqt3 272 27 HOS hos NN cord-325712-9kbnyqt3 272 28 cells cell NNS cord-325712-9kbnyqt3 272 29 [ [ -LRB- cord-325712-9kbnyqt3 272 30 130 130 CD cord-325712-9kbnyqt3 272 31 ] ] -RRB- cord-325712-9kbnyqt3 272 32 . . . cord-325712-9kbnyqt3 273 1 The the DT cord-325712-9kbnyqt3 273 2 ability ability NN cord-325712-9kbnyqt3 273 3 to to TO cord-325712-9kbnyqt3 273 4 detect detect VB cord-325712-9kbnyqt3 273 5 viral viral JJ cord-325712-9kbnyqt3 273 6 fusion fusion NN cord-325712-9kbnyqt3 273 7 in in IN cord-325712-9kbnyqt3 273 8 live live JJ cord-325712-9kbnyqt3 273 9 cells cell NNS cord-325712-9kbnyqt3 273 10 within within IN cord-325712-9kbnyqt3 273 11 the the DT cord-325712-9kbnyqt3 273 12 endocytic endocytic JJ cord-325712-9kbnyqt3 273 13 pathway pathway NN cord-325712-9kbnyqt3 273 14 often often RB cord-325712-9kbnyqt3 273 15 relies rely VBZ cord-325712-9kbnyqt3 273 16 on on IN cord-325712-9kbnyqt3 273 17 labeling label VBG cord-325712-9kbnyqt3 273 18 virions virion NNS cord-325712-9kbnyqt3 273 19 with with IN cord-325712-9kbnyqt3 273 20 quenched quench VBN cord-325712-9kbnyqt3 273 21 amounts amount NNS cord-325712-9kbnyqt3 273 22 of of IN cord-325712-9kbnyqt3 273 23 dye dye NN cord-325712-9kbnyqt3 273 24 . . . cord-325712-9kbnyqt3 274 1 Colocalization Colocalization NNP cord-325712-9kbnyqt3 274 2 of of IN cord-325712-9kbnyqt3 274 3 dequenching dequenche VBG cord-325712-9kbnyqt3 274 4 virions virion NNS cord-325712-9kbnyqt3 274 5 with with IN cord-325712-9kbnyqt3 274 6 labeled label VBN cord-325712-9kbnyqt3 274 7 cellular cellular JJ cord-325712-9kbnyqt3 274 8 components component NNS cord-325712-9kbnyqt3 274 9 , , , cord-325712-9kbnyqt3 274 10 such such JJ cord-325712-9kbnyqt3 274 11 as as IN cord-325712-9kbnyqt3 274 12 clathrin clathrin NN cord-325712-9kbnyqt3 274 13 or or CC cord-325712-9kbnyqt3 274 14 Rab Rab NNP cord-325712-9kbnyqt3 274 15 proteins protein NNS cord-325712-9kbnyqt3 274 16 , , , cord-325712-9kbnyqt3 274 17 can can MD cord-325712-9kbnyqt3 274 18 reveal reveal VB cord-325712-9kbnyqt3 274 19 whether whether IN cord-325712-9kbnyqt3 274 20 fusion fusion NN cord-325712-9kbnyqt3 274 21 occurs occur VBZ cord-325712-9kbnyqt3 274 22 in in IN cord-325712-9kbnyqt3 274 23 early early JJ cord-325712-9kbnyqt3 274 24 or or CC cord-325712-9kbnyqt3 274 25 late late JJ cord-325712-9kbnyqt3 274 26 stage stage NN cord-325712-9kbnyqt3 274 27 endosomes endosome NNS cord-325712-9kbnyqt3 274 28 . . . cord-325712-9kbnyqt3 275 1 This this DT cord-325712-9kbnyqt3 275 2 approach approach NN cord-325712-9kbnyqt3 275 3 has have VBZ cord-325712-9kbnyqt3 275 4 been be VBN cord-325712-9kbnyqt3 275 5 employed employ VBN cord-325712-9kbnyqt3 275 6 in in IN cord-325712-9kbnyqt3 275 7 the the DT cord-325712-9kbnyqt3 275 8 study study NN cord-325712-9kbnyqt3 275 9 of of IN cord-325712-9kbnyqt3 275 10 influenza influenza NN cord-325712-9kbnyqt3 275 11 virus virus NN cord-325712-9kbnyqt3 275 12 , , , cord-325712-9kbnyqt3 275 13 which which WDT cord-325712-9kbnyqt3 275 14 fuses fuse VBZ cord-325712-9kbnyqt3 275 15 in in IN cord-325712-9kbnyqt3 275 16 early early JJ cord-325712-9kbnyqt3 275 17 endosomes endosome NNS cord-325712-9kbnyqt3 275 18 , , , cord-325712-9kbnyqt3 275 19 revealing reveal VBG cord-325712-9kbnyqt3 275 20 that that IN cord-325712-9kbnyqt3 275 21 the the DT cord-325712-9kbnyqt3 275 22 virus virus NN cord-325712-9kbnyqt3 275 23 is be VBZ cord-325712-9kbnyqt3 275 24 able able JJ cord-325712-9kbnyqt3 275 25 to to TO cord-325712-9kbnyqt3 275 26 enter enter VB cord-325712-9kbnyqt3 275 27 a a DT cord-325712-9kbnyqt3 275 28 clathrin clathrin NN cord-325712-9kbnyqt3 275 29 - - HYPH cord-325712-9kbnyqt3 275 30 dependent dependent JJ cord-325712-9kbnyqt3 275 31 manner manner NN cord-325712-9kbnyqt3 275 32 as as RB cord-325712-9kbnyqt3 275 33 well well RB cord-325712-9kbnyqt3 275 34 as as IN cord-325712-9kbnyqt3 275 35 a a DT cord-325712-9kbnyqt3 275 36 clathrin clathrin NN cord-325712-9kbnyqt3 275 37 and and CC cord-325712-9kbnyqt3 275 38 caveolin caveolin JJ cord-325712-9kbnyqt3 275 39 independent independent JJ cord-325712-9kbnyqt3 275 40 fashion fashion NN cord-325712-9kbnyqt3 275 41 , , , cord-325712-9kbnyqt3 275 42 and and CC cord-325712-9kbnyqt3 275 43 viral viral JJ cord-325712-9kbnyqt3 275 44 fusion fusion NN cord-325712-9kbnyqt3 275 45 can can MD cord-325712-9kbnyqt3 275 46 occur occur VB cord-325712-9kbnyqt3 275 47 in in IN cord-325712-9kbnyqt3 275 48 both both DT cord-325712-9kbnyqt3 275 49 pathways pathway NNS cord-325712-9kbnyqt3 275 50 [ [ -LRB- cord-325712-9kbnyqt3 275 51 78 78 CD cord-325712-9kbnyqt3 275 52 ] ] -RRB- cord-325712-9kbnyqt3 275 53 . . . cord-325712-9kbnyqt3 276 1 In in IN cord-325712-9kbnyqt3 276 2 macrophages macrophage NNS cord-325712-9kbnyqt3 276 3 , , , cord-325712-9kbnyqt3 276 4 HIV HIV NNP cord-325712-9kbnyqt3 276 5 undergoes undergo VBZ cord-325712-9kbnyqt3 276 6 fusion fusion NN cord-325712-9kbnyqt3 276 7 in in IN cord-325712-9kbnyqt3 276 8 Rab5A Rab5A NNP cord-325712-9kbnyqt3 276 9 positive positive JJ cord-325712-9kbnyqt3 276 10 endosomes endosome NNS cord-325712-9kbnyqt3 276 11 [ [ -LRB- cord-325712-9kbnyqt3 276 12 100 100 CD cord-325712-9kbnyqt3 276 13 ] ] -RRB- cord-325712-9kbnyqt3 276 14 . . . cord-325712-9kbnyqt3 277 1 Fusion fusion NN cord-325712-9kbnyqt3 277 2 of of IN cord-325712-9kbnyqt3 277 3 Dengue Dengue NNP cord-325712-9kbnyqt3 277 4 virus virus NN cord-325712-9kbnyqt3 277 5 [ [ -LRB- cord-325712-9kbnyqt3 277 6 70 70 CD cord-325712-9kbnyqt3 277 7 ] ] -RRB- cord-325712-9kbnyqt3 277 8 and and CC cord-325712-9kbnyqt3 277 9 Ebola Ebola NNP cord-325712-9kbnyqt3 277 10 virus virus NN cord-325712-9kbnyqt3 277 11 [ [ -LRB- cord-325712-9kbnyqt3 277 12 11 11 CD cord-325712-9kbnyqt3 277 13 ] ] -RRB- cord-325712-9kbnyqt3 277 14 colocalizes colocalize VBZ cord-325712-9kbnyqt3 277 15 with with IN cord-325712-9kbnyqt3 277 16 Rab7 Rab7 NNP cord-325712-9kbnyqt3 277 17 , , , cord-325712-9kbnyqt3 277 18 a a DT cord-325712-9kbnyqt3 277 19 marker marker NN cord-325712-9kbnyqt3 277 20 of of IN cord-325712-9kbnyqt3 277 21 late late JJ cord-325712-9kbnyqt3 277 22 stage stage NN cord-325712-9kbnyqt3 277 23 endosomes endosome NNS cord-325712-9kbnyqt3 277 24 . . . cord-325712-9kbnyqt3 278 1 Alternatively alternatively RB cord-325712-9kbnyqt3 278 2 , , , cord-325712-9kbnyqt3 278 3 endosomal endosomal NNP cord-325712-9kbnyqt3 278 4 fusion fusion NN cord-325712-9kbnyqt3 278 5 may may MD cord-325712-9kbnyqt3 278 6 be be VB cord-325712-9kbnyqt3 278 7 mimicked mimic VBN cord-325712-9kbnyqt3 278 8 by by IN cord-325712-9kbnyqt3 278 9 binding bind VBG cord-325712-9kbnyqt3 278 10 virions virion NNS cord-325712-9kbnyqt3 278 11 to to IN cord-325712-9kbnyqt3 278 12 the the DT cord-325712-9kbnyqt3 278 13 plasma plasma NN cord-325712-9kbnyqt3 278 14 membrane membrane NN cord-325712-9kbnyqt3 278 15 then then RB cord-325712-9kbnyqt3 278 16 lowering lower VBG cord-325712-9kbnyqt3 278 17 the the DT cord-325712-9kbnyqt3 278 18 extracellular extracellular JJ cord-325712-9kbnyqt3 278 19 pH. ph. NN cord-325712-9kbnyqt3 278 20 This this DT cord-325712-9kbnyqt3 278 21 method method NN cord-325712-9kbnyqt3 278 22 of of IN cord-325712-9kbnyqt3 278 23 acid acid NN cord-325712-9kbnyqt3 278 24 - - HYPH cord-325712-9kbnyqt3 278 25 induced induce VBN cord-325712-9kbnyqt3 278 26 endosomal endosomal NNP cord-325712-9kbnyqt3 278 27 bypass bypass NN cord-325712-9kbnyqt3 278 28 has have VBZ cord-325712-9kbnyqt3 278 29 been be VBN cord-325712-9kbnyqt3 278 30 employed employ VBN cord-325712-9kbnyqt3 278 31 to to TO cord-325712-9kbnyqt3 278 32 characterize characterize VB cord-325712-9kbnyqt3 278 33 avian avian JJ cord-325712-9kbnyqt3 278 34 sarcoma sarcoma NN cord-325712-9kbnyqt3 278 35 and and CC cord-325712-9kbnyqt3 278 36 leukosis leukosis NN cord-325712-9kbnyqt3 278 37 virus virus NN cord-325712-9kbnyqt3 278 38 fusion fusion NN cord-325712-9kbnyqt3 278 39 behavior behavior NN cord-325712-9kbnyqt3 278 40 [ [ -LRB- cord-325712-9kbnyqt3 278 41 131 131 CD cord-325712-9kbnyqt3 278 42 ] ] -RRB- cord-325712-9kbnyqt3 278 43 . . . cord-325712-9kbnyqt3 279 1 Viral viral JJ cord-325712-9kbnyqt3 279 2 fusion fusion NN cord-325712-9kbnyqt3 279 3 can can MD cord-325712-9kbnyqt3 279 4 also also RB cord-325712-9kbnyqt3 279 5 be be VB cord-325712-9kbnyqt3 279 6 monitored monitor VBN cord-325712-9kbnyqt3 279 7 by by IN cord-325712-9kbnyqt3 279 8 observing observe VBG cord-325712-9kbnyqt3 279 9 the the DT cord-325712-9kbnyqt3 279 10 release release NN cord-325712-9kbnyqt3 279 11 of of IN cord-325712-9kbnyqt3 279 12 fluorescent fluorescent JJ cord-325712-9kbnyqt3 279 13 viral viral JJ cord-325712-9kbnyqt3 279 14 cargo cargo NN cord-325712-9kbnyqt3 279 15 . . . cord-325712-9kbnyqt3 280 1 Avian avian JJ cord-325712-9kbnyqt3 280 2 sarcoma sarcoma NN cord-325712-9kbnyqt3 280 3 and and CC cord-325712-9kbnyqt3 280 4 leukosis leukosis NN cord-325712-9kbnyqt3 280 5 virions virion NNS cord-325712-9kbnyqt3 280 6 labeled label VBN cord-325712-9kbnyqt3 280 7 with with IN cord-325712-9kbnyqt3 280 8 fluorescent fluorescent JJ cord-325712-9kbnyqt3 280 9 cargo cargo NN cord-325712-9kbnyqt3 280 10 and and CC cord-325712-9kbnyqt3 280 11 an an DT cord-325712-9kbnyqt3 280 12 envelope envelope NN cord-325712-9kbnyqt3 280 13 pH ph NN cord-325712-9kbnyqt3 280 14 sensor sensor NN cord-325712-9kbnyqt3 280 15 showed show VBD cord-325712-9kbnyqt3 280 16 little little JJ cord-325712-9kbnyqt3 280 17 correlation correlation NN cord-325712-9kbnyqt3 280 18 between between IN cord-325712-9kbnyqt3 280 19 endosomal endosomal NNP cord-325712-9kbnyqt3 280 20 pH pH NNP cord-325712-9kbnyqt3 280 21 and and CC cord-325712-9kbnyqt3 280 22 fusion fusion NN cord-325712-9kbnyqt3 280 23 lag lag NN cord-325712-9kbnyqt3 280 24 time time NN cord-325712-9kbnyqt3 280 25 [ [ -LRB- cord-325712-9kbnyqt3 280 26 132 132 CD cord-325712-9kbnyqt3 280 27 ] ] -RRB- cord-325712-9kbnyqt3 280 28 . . . cord-325712-9kbnyqt3 281 1 However however RB cord-325712-9kbnyqt3 281 2 fusion fusion NN cord-325712-9kbnyqt3 281 3 lag lag NN cord-325712-9kbnyqt3 281 4 time time NN cord-325712-9kbnyqt3 281 5 and and CC cord-325712-9kbnyqt3 281 6 pore pore NN cord-325712-9kbnyqt3 281 7 size size NN cord-325712-9kbnyqt3 281 8 did do VBD cord-325712-9kbnyqt3 281 9 vary vary VB cord-325712-9kbnyqt3 281 10 with with IN cord-325712-9kbnyqt3 281 11 surface surface NN cord-325712-9kbnyqt3 281 12 receptor receptor NN cord-325712-9kbnyqt3 281 13 and and CC cord-325712-9kbnyqt3 281 14 endosome endosome NN cord-325712-9kbnyqt3 281 15 type type NN cord-325712-9kbnyqt3 281 16 , , , cord-325712-9kbnyqt3 281 17 indicating indicate VBG cord-325712-9kbnyqt3 281 18 that that IN cord-325712-9kbnyqt3 281 19 endosomal endosomal NNP cord-325712-9kbnyqt3 281 20 composition composition NN cord-325712-9kbnyqt3 281 21 may may MD cord-325712-9kbnyqt3 281 22 modulate modulate VB cord-325712-9kbnyqt3 281 23 fusion fusion NN cord-325712-9kbnyqt3 281 24 [ [ -LRB- cord-325712-9kbnyqt3 281 25 35 35 CD cord-325712-9kbnyqt3 281 26 , , , cord-325712-9kbnyqt3 281 27 132 132 CD cord-325712-9kbnyqt3 281 28 , , , cord-325712-9kbnyqt3 281 29 133 133 CD cord-325712-9kbnyqt3 281 30 ] ] -RRB- cord-325712-9kbnyqt3 281 31 . . . cord-325712-9kbnyqt3 282 1 In in IN cord-325712-9kbnyqt3 282 2 the the DT cord-325712-9kbnyqt3 282 3 case case NN cord-325712-9kbnyqt3 282 4 of of IN cord-325712-9kbnyqt3 282 5 vesicular vesicular JJ cord-325712-9kbnyqt3 282 6 stomatitis stomatitis NN cord-325712-9kbnyqt3 282 7 virus virus NN cord-325712-9kbnyqt3 282 8 , , , cord-325712-9kbnyqt3 282 9 cytoplasmic cytoplasmic JJ cord-325712-9kbnyqt3 282 10 nucleocapsid nucleocapsid NN cord-325712-9kbnyqt3 282 11 release release NN cord-325712-9kbnyqt3 282 12 does do VBZ cord-325712-9kbnyqt3 282 13 not not RB cord-325712-9kbnyqt3 282 14 necessarily necessarily RB cord-325712-9kbnyqt3 282 15 immediately immediately RB cord-325712-9kbnyqt3 282 16 follow follow VBP cord-325712-9kbnyqt3 282 17 fusion fusion NN cord-325712-9kbnyqt3 282 18 . . . cord-325712-9kbnyqt3 283 1 VSV VSV NNP cord-325712-9kbnyqt3 283 2 has have VBZ cord-325712-9kbnyqt3 283 3 been be VBN cord-325712-9kbnyqt3 283 4 shown show VBN cord-325712-9kbnyqt3 283 5 to to TO cord-325712-9kbnyqt3 283 6 undergo undergo VB cord-325712-9kbnyqt3 283 7 fusion fusion NN cord-325712-9kbnyqt3 283 8 between between IN cord-325712-9kbnyqt3 283 9 the the DT cord-325712-9kbnyqt3 283 10 early early JJ cord-325712-9kbnyqt3 283 11 and and CC cord-325712-9kbnyqt3 283 12 late late JJ cord-325712-9kbnyqt3 283 13 endosome endosome NN cord-325712-9kbnyqt3 283 14 stage stage NN cord-325712-9kbnyqt3 283 15 [ [ -LRB- cord-325712-9kbnyqt3 283 16 134 134 CD cord-325712-9kbnyqt3 283 17 ] ] -RRB- cord-325712-9kbnyqt3 283 18 . . . cord-325712-9kbnyqt3 284 1 With with IN cord-325712-9kbnyqt3 284 2 the the DT cord-325712-9kbnyqt3 284 3 lipid lipid NN cord-325712-9kbnyqt3 284 4 bilayer bilayer NN cord-325712-9kbnyqt3 284 5 platform platform NN cord-325712-9kbnyqt3 284 6 , , , cord-325712-9kbnyqt3 284 7 hemifusion hemifusion NN cord-325712-9kbnyqt3 284 8 and and CC cord-325712-9kbnyqt3 284 9 pore pore NN cord-325712-9kbnyqt3 284 10 formation formation NN cord-325712-9kbnyqt3 284 11 can can MD cord-325712-9kbnyqt3 284 12 be be VB cord-325712-9kbnyqt3 284 13 observed observe VBN cord-325712-9kbnyqt3 284 14 within within IN cord-325712-9kbnyqt3 284 15 the the DT cord-325712-9kbnyqt3 284 16 same same JJ cord-325712-9kbnyqt3 284 17 particle particle NN cord-325712-9kbnyqt3 284 18 by by IN cord-325712-9kbnyqt3 284 19 dual dual JJ cord-325712-9kbnyqt3 284 20 - - HYPH cord-325712-9kbnyqt3 284 21 labeling label VBG cord-325712-9kbnyqt3 284 22 the the DT cord-325712-9kbnyqt3 284 23 viral viral JJ cord-325712-9kbnyqt3 284 24 envelope envelope NN cord-325712-9kbnyqt3 284 25 and and CC cord-325712-9kbnyqt3 284 26 contents content NNS cord-325712-9kbnyqt3 284 27 with with IN cord-325712-9kbnyqt3 284 28 different different JJ cord-325712-9kbnyqt3 284 29 colors color NNS cord-325712-9kbnyqt3 284 30 ( ( -LRB- cord-325712-9kbnyqt3 284 31 Fig Fig NNP cord-325712-9kbnyqt3 284 32 . . . cord-325712-9kbnyqt3 284 33 2.6 2.6 CD cord-325712-9kbnyqt3 284 34 ) ) -RRB- cord-325712-9kbnyqt3 284 35 . . . cord-325712-9kbnyqt3 285 1 By by IN cord-325712-9kbnyqt3 285 2 using use VBG cord-325712-9kbnyqt3 285 3 a a DT cord-325712-9kbnyqt3 285 4 flow flow NN cord-325712-9kbnyqt3 285 5 cell cell NN cord-325712-9kbnyqt3 285 6 or or CC cord-325712-9kbnyqt3 285 7 microfluidic microfluidic JJ cord-325712-9kbnyqt3 285 8 device device NN cord-325712-9kbnyqt3 285 9 , , , cord-325712-9kbnyqt3 285 10 this this DT cord-325712-9kbnyqt3 285 11 platform platform NN cord-325712-9kbnyqt3 285 12 also also RB cord-325712-9kbnyqt3 285 13 enables enable VBZ cord-325712-9kbnyqt3 285 14 control control NN cord-325712-9kbnyqt3 285 15 over over IN cord-325712-9kbnyqt3 285 16 the the DT cord-325712-9kbnyqt3 285 17 timing timing NN cord-325712-9kbnyqt3 285 18 of of IN cord-325712-9kbnyqt3 285 19 fusion fusion NN cord-325712-9kbnyqt3 285 20 trigger(s trigger(s NN cord-325712-9kbnyqt3 285 21 ) ) -RRB- cord-325712-9kbnyqt3 285 22 or or CC cord-325712-9kbnyqt3 285 23 other other JJ cord-325712-9kbnyqt3 285 24 environmental environmental JJ cord-325712-9kbnyqt3 285 25 changes change NNS cord-325712-9kbnyqt3 285 26 within within IN cord-325712-9kbnyqt3 285 27 the the DT cord-325712-9kbnyqt3 285 28 viral viral JJ cord-325712-9kbnyqt3 285 29 environment environment NN cord-325712-9kbnyqt3 285 30 . . . cord-325712-9kbnyqt3 286 1 A a DT cord-325712-9kbnyqt3 286 2 common common JJ cord-325712-9kbnyqt3 286 3 fusion fusion NN cord-325712-9kbnyqt3 286 4 trigger trigger NN cord-325712-9kbnyqt3 286 5 is be VBZ cord-325712-9kbnyqt3 286 6 a a DT cord-325712-9kbnyqt3 286 7 drop drop NN cord-325712-9kbnyqt3 286 8 in in IN cord-325712-9kbnyqt3 286 9 pH. ph. NN cord-325712-9kbnyqt3 287 1 To to TO cord-325712-9kbnyqt3 287 2 trigger trigger VB cord-325712-9kbnyqt3 287 3 fusion fusion NN cord-325712-9kbnyqt3 287 4 , , , cord-325712-9kbnyqt3 287 5 acidic acidic JJ cord-325712-9kbnyqt3 287 6 buffer buffer NN cord-325712-9kbnyqt3 287 7 can can MD cord-325712-9kbnyqt3 287 8 be be VB cord-325712-9kbnyqt3 287 9 passed pass VBN cord-325712-9kbnyqt3 287 10 over over IN cord-325712-9kbnyqt3 287 11 the the DT cord-325712-9kbnyqt3 287 12 bilayer bilayer NN cord-325712-9kbnyqt3 287 13 inside inside IN cord-325712-9kbnyqt3 287 14 a a DT cord-325712-9kbnyqt3 287 15 microfluidic microfluidic JJ cord-325712-9kbnyqt3 287 16 device device NN cord-325712-9kbnyqt3 287 17 . . . cord-325712-9kbnyqt3 288 1 Incorporation Incorporation NNP cord-325712-9kbnyqt3 288 2 of of IN cord-325712-9kbnyqt3 288 3 pH pH NNP cord-325712-9kbnyqt3 288 4 sensitive sensitive JJ cord-325712-9kbnyqt3 288 5 dye dye NN cord-325712-9kbnyqt3 288 6 into into IN cord-325712-9kbnyqt3 288 7 the the DT cord-325712-9kbnyqt3 288 8 bilayer bilayer NN cord-325712-9kbnyqt3 288 9 enables enable VBZ cord-325712-9kbnyqt3 288 10 detection detection NN cord-325712-9kbnyqt3 288 11 of of IN cord-325712-9kbnyqt3 288 12 the the DT cord-325712-9kbnyqt3 288 13 time time NN cord-325712-9kbnyqt3 288 14 at at IN cord-325712-9kbnyqt3 288 15 which which WDT cord-325712-9kbnyqt3 288 16 bound bind VBN cord-325712-9kbnyqt3 288 17 virions virion NNS cord-325712-9kbnyqt3 288 18 encounter encounter VBP cord-325712-9kbnyqt3 288 19 the the DT cord-325712-9kbnyqt3 288 20 acid acid NN cord-325712-9kbnyqt3 288 21 [ [ -LRB- cord-325712-9kbnyqt3 288 22 33 33 CD cord-325712-9kbnyqt3 288 23 ] ] -RRB- cord-325712-9kbnyqt3 288 24 . . . cord-325712-9kbnyqt3 289 1 Alternatively alternatively RB cord-325712-9kbnyqt3 289 2 , , , cord-325712-9kbnyqt3 289 3 ultraviolet ultraviolet JJ cord-325712-9kbnyqt3 289 4 light light NN cord-325712-9kbnyqt3 289 5 can can MD cord-325712-9kbnyqt3 289 6 be be VB cord-325712-9kbnyqt3 289 7 used use VBN cord-325712-9kbnyqt3 289 8 to to TO cord-325712-9kbnyqt3 289 9 " " `` cord-325712-9kbnyqt3 289 10 uncage uncage NN cord-325712-9kbnyqt3 289 11 " " '' cord-325712-9kbnyqt3 289 12 protons proton NNS cord-325712-9kbnyqt3 289 13 from from IN cord-325712-9kbnyqt3 289 14 onitrobenzaldehyde onitrobenzaldehyde NNP cord-325712-9kbnyqt3 289 15 in in IN cord-325712-9kbnyqt3 289 16 solution solution NN cord-325712-9kbnyqt3 289 17 to to TO cord-325712-9kbnyqt3 289 18 rapidly rapidly RB cord-325712-9kbnyqt3 289 19 acidify acidify VB cord-325712-9kbnyqt3 289 20 the the DT cord-325712-9kbnyqt3 289 21 bilayer bilayer NN cord-325712-9kbnyqt3 289 22 and and CC cord-325712-9kbnyqt3 289 23 virions virion NNS cord-325712-9kbnyqt3 289 24 [ [ -LRB- cord-325712-9kbnyqt3 289 25 12 12 CD cord-325712-9kbnyqt3 289 26 ] ] -RRB- cord-325712-9kbnyqt3 289 27 . . . cord-325712-9kbnyqt3 290 1 Both both DT cord-325712-9kbnyqt3 290 2 of of IN cord-325712-9kbnyqt3 290 3 these these DT cord-325712-9kbnyqt3 290 4 methods method NNS cord-325712-9kbnyqt3 290 5 enable enable VBP cord-325712-9kbnyqt3 290 6 measurement measurement NN cord-325712-9kbnyqt3 290 7 of of IN cord-325712-9kbnyqt3 290 8 the the DT cord-325712-9kbnyqt3 290 9 lag lag JJ cord-325712-9kbnyqt3 290 10 time time NN cord-325712-9kbnyqt3 290 11 between between IN cord-325712-9kbnyqt3 290 12 exposure exposure NN cord-325712-9kbnyqt3 290 13 to to IN cord-325712-9kbnyqt3 290 14 a a DT cord-325712-9kbnyqt3 290 15 fusion fusion NN cord-325712-9kbnyqt3 290 16 trigger trigger NN cord-325712-9kbnyqt3 290 17 and and CC cord-325712-9kbnyqt3 290 18 the the DT cord-325712-9kbnyqt3 290 19 onset onset NN cord-325712-9kbnyqt3 290 20 of of IN cord-325712-9kbnyqt3 290 21 hemifusion hemifusion NN cord-325712-9kbnyqt3 290 22 . . . cord-325712-9kbnyqt3 291 1 By by IN cord-325712-9kbnyqt3 291 2 analyzing analyze VBG cord-325712-9kbnyqt3 291 3 this this DT cord-325712-9kbnyqt3 291 4 lag lag NN cord-325712-9kbnyqt3 291 5 time time NN cord-325712-9kbnyqt3 291 6 for for IN cord-325712-9kbnyqt3 291 7 hundreds hundred NNS cord-325712-9kbnyqt3 291 8 of of IN cord-325712-9kbnyqt3 291 9 individual individual JJ cord-325712-9kbnyqt3 291 10 fusion fusion NN cord-325712-9kbnyqt3 291 11 events event NNS cord-325712-9kbnyqt3 291 12 , , , cord-325712-9kbnyqt3 291 13 the the DT cord-325712-9kbnyqt3 291 14 rate rate NN cord-325712-9kbnyqt3 291 15 constants constant NNS cord-325712-9kbnyqt3 291 16 of of IN cord-325712-9kbnyqt3 291 17 hemifusion hemifusion NN cord-325712-9kbnyqt3 291 18 can can MD cord-325712-9kbnyqt3 291 19 be be VB cord-325712-9kbnyqt3 291 20 calculated calculate VBN cord-325712-9kbnyqt3 291 21 . . . cord-325712-9kbnyqt3 292 1 Pore pore NN cord-325712-9kbnyqt3 292 2 formation formation NN cord-325712-9kbnyqt3 292 3 can can MD cord-325712-9kbnyqt3 292 4 be be VB cord-325712-9kbnyqt3 292 5 monitored monitor VBN cord-325712-9kbnyqt3 292 6 by by IN cord-325712-9kbnyqt3 292 7 particles particle NNS cord-325712-9kbnyqt3 292 8 also also RB cord-325712-9kbnyqt3 292 9 containing contain VBG cord-325712-9kbnyqt3 292 10 internal internal JJ cord-325712-9kbnyqt3 292 11 capsid capsid NN cord-325712-9kbnyqt3 292 12 dyes dye NNS cord-325712-9kbnyqt3 292 13 . . . cord-325712-9kbnyqt3 293 1 Monitoring monitor VBG cord-325712-9kbnyqt3 293 2 the the DT cord-325712-9kbnyqt3 293 3 drop drop NN cord-325712-9kbnyqt3 293 4 in in IN cord-325712-9kbnyqt3 293 5 signal signal NN cord-325712-9kbnyqt3 293 6 of of IN cord-325712-9kbnyqt3 293 7 this this DT cord-325712-9kbnyqt3 293 8 co co NN cord-325712-9kbnyqt3 293 9 - - JJ cord-325712-9kbnyqt3 293 10 localized localized JJ cord-325712-9kbnyqt3 293 11 fluorophore fluorophore NN cord-325712-9kbnyqt3 293 12 reports report VBZ cord-325712-9kbnyqt3 293 13 the the DT cord-325712-9kbnyqt3 293 14 opening opening NN cord-325712-9kbnyqt3 293 15 of of IN cord-325712-9kbnyqt3 293 16 the the DT cord-325712-9kbnyqt3 293 17 fusion fusion NN cord-325712-9kbnyqt3 293 18 pore pore NN cord-325712-9kbnyqt3 293 19 . . . cord-325712-9kbnyqt3 294 1 If if IN cord-325712-9kbnyqt3 294 2 there there EX cord-325712-9kbnyqt3 294 3 is be VBZ cord-325712-9kbnyqt3 294 4 a a DT cord-325712-9kbnyqt3 294 5 single single JJ cord-325712-9kbnyqt3 294 6 rate rate NN cord-325712-9kbnyqt3 294 7 liming liming NN cord-325712-9kbnyqt3 294 8 step step NN cord-325712-9kbnyqt3 294 9 , , , cord-325712-9kbnyqt3 294 10 the the DT cord-325712-9kbnyqt3 294 11 distribution distribution NN cord-325712-9kbnyqt3 294 12 of of IN cord-325712-9kbnyqt3 294 13 lag lag NN cord-325712-9kbnyqt3 294 14 times time NNS cord-325712-9kbnyqt3 294 15 will will MD cord-325712-9kbnyqt3 294 16 follow follow VB cord-325712-9kbnyqt3 294 17 a a DT cord-325712-9kbnyqt3 294 18 simple simple JJ cord-325712-9kbnyqt3 294 19 exponential exponential JJ cord-325712-9kbnyqt3 294 20 decay decay NN cord-325712-9kbnyqt3 294 21 , , , cord-325712-9kbnyqt3 294 22 with with IN cord-325712-9kbnyqt3 294 23 the the DT cord-325712-9kbnyqt3 294 24 decay decay NN cord-325712-9kbnyqt3 294 25 constant constant NN cord-325712-9kbnyqt3 294 26 corresponding correspond VBG cord-325712-9kbnyqt3 294 27 to to IN cord-325712-9kbnyqt3 294 28 the the DT cord-325712-9kbnyqt3 294 29 rate rate NN cord-325712-9kbnyqt3 294 30 constant constant NN cord-325712-9kbnyqt3 294 31 of of IN cord-325712-9kbnyqt3 294 32 that that DT cord-325712-9kbnyqt3 294 33 limiting limit VBG cord-325712-9kbnyqt3 294 34 step step NN cord-325712-9kbnyqt3 294 35 . . . cord-325712-9kbnyqt3 295 1 If if IN cord-325712-9kbnyqt3 295 2 there there EX cord-325712-9kbnyqt3 295 3 are be VBP cord-325712-9kbnyqt3 295 4 multiple multiple JJ cord-325712-9kbnyqt3 295 5 rate rate NN cord-325712-9kbnyqt3 295 6 liming liming NN cord-325712-9kbnyqt3 295 7 steps step NNS cord-325712-9kbnyqt3 295 8 , , , cord-325712-9kbnyqt3 295 9 the the DT cord-325712-9kbnyqt3 295 10 lag lag NN cord-325712-9kbnyqt3 295 11 time time NN cord-325712-9kbnyqt3 295 12 distribution distribution NN cord-325712-9kbnyqt3 295 13 will will MD cord-325712-9kbnyqt3 295 14 rise rise VB cord-325712-9kbnyqt3 295 15 and and CC cord-325712-9kbnyqt3 295 16 decay decay VB cord-325712-9kbnyqt3 295 17 [ [ -LRB- cord-325712-9kbnyqt3 295 18 135 135 CD cord-325712-9kbnyqt3 295 19 ] ] -RRB- cord-325712-9kbnyqt3 295 20 . . . cord-325712-9kbnyqt3 296 1 A a DT cord-325712-9kbnyqt3 296 2 simple simple JJ cord-325712-9kbnyqt3 296 3 approach approach NN cord-325712-9kbnyqt3 296 4 to to IN cord-325712-9kbnyqt3 296 5 quantifying quantify VBG cord-325712-9kbnyqt3 296 6 the the DT cord-325712-9kbnyqt3 296 7 kinetics kinetic NNS cord-325712-9kbnyqt3 296 8 of of IN cord-325712-9kbnyqt3 296 9 hemifusion hemifusion NN cord-325712-9kbnyqt3 296 10 and and CC cord-325712-9kbnyqt3 296 11 pore pore NN cord-325712-9kbnyqt3 296 12 formation formation NN cord-325712-9kbnyqt3 296 13 is be VBZ cord-325712-9kbnyqt3 296 14 fitting fit VBG cord-325712-9kbnyqt3 296 15 the the DT cord-325712-9kbnyqt3 296 16 cumulative cumulative JJ cord-325712-9kbnyqt3 296 17 distribution distribution NN cord-325712-9kbnyqt3 296 18 of of IN cord-325712-9kbnyqt3 296 19 fusion fusion NN cord-325712-9kbnyqt3 296 20 events event NNS cord-325712-9kbnyqt3 296 21 to to IN cord-325712-9kbnyqt3 296 22 a a DT cord-325712-9kbnyqt3 296 23 convolution convolution NN cord-325712-9kbnyqt3 296 24 of of IN cord-325712-9kbnyqt3 296 25 Poisson Poisson NNP cord-325712-9kbnyqt3 296 26 processes process NNS cord-325712-9kbnyqt3 296 27 with with IN cord-325712-9kbnyqt3 296 28 the the DT cord-325712-9kbnyqt3 296 29 equation equation NN cord-325712-9kbnyqt3 296 30 : : : cord-325712-9kbnyqt3 296 31 where where WRB cord-325712-9kbnyqt3 296 32 P p NN cord-325712-9kbnyqt3 296 33 is be VBZ cord-325712-9kbnyqt3 296 34 the the DT cord-325712-9kbnyqt3 296 35 probability probability NN cord-325712-9kbnyqt3 296 36 of of IN cord-325712-9kbnyqt3 296 37 a a DT cord-325712-9kbnyqt3 296 38 virion virion NN cord-325712-9kbnyqt3 296 39 being be VBG cord-325712-9kbnyqt3 296 40 in in IN cord-325712-9kbnyqt3 296 41 that that DT cord-325712-9kbnyqt3 296 42 state state NN cord-325712-9kbnyqt3 296 43 ( ( -LRB- cord-325712-9kbnyqt3 296 44 hemifused hemifuse VBN cord-325712-9kbnyqt3 296 45 or or CC cord-325712-9kbnyqt3 296 46 pore pore NN cord-325712-9kbnyqt3 296 47 forming form VBG cord-325712-9kbnyqt3 296 48 ) ) -RRB- cord-325712-9kbnyqt3 296 49 at at IN cord-325712-9kbnyqt3 296 50 time time NN cord-325712-9kbnyqt3 296 51 t t NN cord-325712-9kbnyqt3 296 52 after after IN cord-325712-9kbnyqt3 296 53 the the DT cord-325712-9kbnyqt3 296 54 fusion fusion NN cord-325712-9kbnyqt3 296 55 trigger trigger NN cord-325712-9kbnyqt3 296 56 has have VBZ cord-325712-9kbnyqt3 296 57 been be VBN cord-325712-9kbnyqt3 296 58 added add VBN cord-325712-9kbnyqt3 296 59 and and CC cord-325712-9kbnyqt3 296 60 Γ(t Γ(t NNP cord-325712-9kbnyqt3 296 61 ) ) -RRB- cord-325712-9kbnyqt3 296 62 is be VBZ cord-325712-9kbnyqt3 296 63 the the DT cord-325712-9kbnyqt3 296 64 gamma gamma NN cord-325712-9kbnyqt3 296 65 distribution distribution NN cord-325712-9kbnyqt3 296 66 function function NN cord-325712-9kbnyqt3 296 67 . . . cord-325712-9kbnyqt3 297 1 This this DT cord-325712-9kbnyqt3 297 2 fit fit NN cord-325712-9kbnyqt3 297 3 yields yield NNS cord-325712-9kbnyqt3 298 1 k k NNP cord-325712-9kbnyqt3 298 2 , , , cord-325712-9kbnyqt3 298 3 the the DT cord-325712-9kbnyqt3 298 4 rate rate NN cord-325712-9kbnyqt3 298 5 constant constant NN cord-325712-9kbnyqt3 298 6 of of IN cord-325712-9kbnyqt3 298 7 that that DT cord-325712-9kbnyqt3 298 8 step step NN cord-325712-9kbnyqt3 298 9 , , , cord-325712-9kbnyqt3 298 10 and and CC cord-325712-9kbnyqt3 298 11 N n CD cord-325712-9kbnyqt3 298 12 , , , cord-325712-9kbnyqt3 298 13 the the DT cord-325712-9kbnyqt3 298 14 number number NN cord-325712-9kbnyqt3 298 15 of of IN cord-325712-9kbnyqt3 298 16 stochastic stochastic JJ cord-325712-9kbnyqt3 298 17 rate rate NN cord-325712-9kbnyqt3 298 18 limiting limit VBG cord-325712-9kbnyqt3 298 19 events event NNS cord-325712-9kbnyqt3 298 20 governing govern VBG cord-325712-9kbnyqt3 298 21 the the DT cord-325712-9kbnyqt3 298 22 kinetics kinetic NNS cord-325712-9kbnyqt3 298 23 of of IN cord-325712-9kbnyqt3 298 24 that that DT cord-325712-9kbnyqt3 298 25 step step NN cord-325712-9kbnyqt3 298 26 [ [ -LRB- cord-325712-9kbnyqt3 298 27 33 33 CD cord-325712-9kbnyqt3 298 28 ] ] -RRB- cord-325712-9kbnyqt3 298 29 . . . cord-325712-9kbnyqt3 299 1 If if IN cord-325712-9kbnyqt3 299 2 there there EX cord-325712-9kbnyqt3 299 3 is be VBZ cord-325712-9kbnyqt3 299 4 only only RB cord-325712-9kbnyqt3 299 5 one one CD cord-325712-9kbnyqt3 299 6 rate rate NN cord-325712-9kbnyqt3 299 7 - - HYPH cord-325712-9kbnyqt3 299 8 limiting limit VBG cord-325712-9kbnyqt3 299 9 step step NN cord-325712-9kbnyqt3 299 10 ( ( -LRB- cord-325712-9kbnyqt3 299 11 N n NN cord-325712-9kbnyqt3 299 12 ¼ ¼ NN cord-325712-9kbnyqt3 299 13 1 1 CD cord-325712-9kbnyqt3 299 14 ) ) -RRB- cord-325712-9kbnyqt3 299 15 , , , cord-325712-9kbnyqt3 299 16 the the DT cord-325712-9kbnyqt3 299 17 above above JJ cord-325712-9kbnyqt3 299 18 equation equation NN cord-325712-9kbnyqt3 299 19 simplifies simplify VBZ cord-325712-9kbnyqt3 299 20 to to IN cord-325712-9kbnyqt3 299 21 a a DT cord-325712-9kbnyqt3 299 22 single single JJ cord-325712-9kbnyqt3 299 23 exponential exponential JJ cord-325712-9kbnyqt3 299 24 decay decay NN cord-325712-9kbnyqt3 299 25 . . . cord-325712-9kbnyqt3 300 1 As as IN cord-325712-9kbnyqt3 300 2 the the DT cord-325712-9kbnyqt3 300 3 number number NN cord-325712-9kbnyqt3 300 4 of of IN cord-325712-9kbnyqt3 300 5 rate rate NN cord-325712-9kbnyqt3 300 6 - - HYPH cord-325712-9kbnyqt3 300 7 limiting limit VBG cord-325712-9kbnyqt3 300 8 steps step NNS cord-325712-9kbnyqt3 300 9 increases increase NNS cord-325712-9kbnyqt3 300 10 , , , cord-325712-9kbnyqt3 300 11 more more JJR cord-325712-9kbnyqt3 300 12 events event NNS cord-325712-9kbnyqt3 300 13 must must MD cord-325712-9kbnyqt3 300 14 be be VB cord-325712-9kbnyqt3 300 15 observed observe VBN cord-325712-9kbnyqt3 300 16 to to TO cord-325712-9kbnyqt3 300 17 accurately accurately RB cord-325712-9kbnyqt3 300 18 calculate calculate VB cord-325712-9kbnyqt3 300 19 N. N. NNP cord-325712-9kbnyqt3 300 20 For for IN cord-325712-9kbnyqt3 300 21 processes process NNS cord-325712-9kbnyqt3 300 22 with with IN cord-325712-9kbnyqt3 300 23 three three CD cord-325712-9kbnyqt3 300 24 steps step NNS cord-325712-9kbnyqt3 300 25 or or CC cord-325712-9kbnyqt3 300 26 fewer few JJR cord-325712-9kbnyqt3 300 27 , , , cord-325712-9kbnyqt3 300 28 50 50 CD cord-325712-9kbnyqt3 300 29 events event NNS cord-325712-9kbnyqt3 300 30 is be VBZ cord-325712-9kbnyqt3 300 31 sufficient sufficient JJ cord-325712-9kbnyqt3 300 32 to to TO cord-325712-9kbnyqt3 300 33 calculate calculate VB cord-325712-9kbnyqt3 300 34 N n CD cord-325712-9kbnyqt3 300 35 with with IN cord-325712-9kbnyqt3 300 36 a a DT cord-325712-9kbnyqt3 300 37 standard standard JJ cord-325712-9kbnyqt3 300 38 deviation deviation NN cord-325712-9kbnyqt3 300 39 of of IN cord-325712-9kbnyqt3 300 40 1 1 CD cord-325712-9kbnyqt3 300 41 [ [ -LRB- cord-325712-9kbnyqt3 300 42 15 15 CD cord-325712-9kbnyqt3 300 43 ] ] -RRB- cord-325712-9kbnyqt3 300 44 . . . cord-325712-9kbnyqt3 301 1 There there EX cord-325712-9kbnyqt3 301 2 are be VBP cord-325712-9kbnyqt3 301 3 other other JJ cord-325712-9kbnyqt3 301 4 more more RBR cord-325712-9kbnyqt3 301 5 complex complex JJ cord-325712-9kbnyqt3 301 6 methods method NNS cord-325712-9kbnyqt3 301 7 for for IN cord-325712-9kbnyqt3 301 8 fitting fitting JJ cord-325712-9kbnyqt3 301 9 lag lag NN cord-325712-9kbnyqt3 301 10 time time NN cord-325712-9kbnyqt3 301 11 distributions distribution NNS cord-325712-9kbnyqt3 301 12 that that WDT cord-325712-9kbnyqt3 301 13 may may MD cord-325712-9kbnyqt3 301 14 capture capture VB cord-325712-9kbnyqt3 301 15 more more JJR cord-325712-9kbnyqt3 301 16 of of IN cord-325712-9kbnyqt3 301 17 the the DT cord-325712-9kbnyqt3 301 18 details detail NNS cord-325712-9kbnyqt3 301 19 of of IN cord-325712-9kbnyqt3 301 20 hemifusion hemifusion NN cord-325712-9kbnyqt3 301 21 [ [ -LRB- cord-325712-9kbnyqt3 301 22 136 136 CD cord-325712-9kbnyqt3 301 23 ] ] -RRB- cord-325712-9kbnyqt3 301 24 . . . cord-325712-9kbnyqt3 302 1 Viruses virus NNS cord-325712-9kbnyqt3 302 2 with with IN cord-325712-9kbnyqt3 302 3 Class class NN cord-325712-9kbnyqt3 302 4 I i NN cord-325712-9kbnyqt3 302 5 , , , cord-325712-9kbnyqt3 302 6 Class Class NNP cord-325712-9kbnyqt3 302 7 II II NNP cord-325712-9kbnyqt3 302 8 and and CC cord-325712-9kbnyqt3 302 9 Class Class NNP cord-325712-9kbnyqt3 302 10 III III NNP cord-325712-9kbnyqt3 302 11 fusion fusion NN cord-325712-9kbnyqt3 302 12 proteins protein NNS cord-325712-9kbnyqt3 302 13 have have VBP cord-325712-9kbnyqt3 302 14 been be VBN cord-325712-9kbnyqt3 302 15 studied study VBN cord-325712-9kbnyqt3 302 16 at at IN cord-325712-9kbnyqt3 302 17 the the DT cord-325712-9kbnyqt3 302 18 single single JJ cord-325712-9kbnyqt3 302 19 virion virion NN cord-325712-9kbnyqt3 302 20 level level NN cord-325712-9kbnyqt3 302 21 with with IN cord-325712-9kbnyqt3 302 22 SLBs slb NNS cord-325712-9kbnyqt3 302 23 . . . cord-325712-9kbnyqt3 303 1 The the DT cord-325712-9kbnyqt3 303 2 kinetic kinetic JJ cord-325712-9kbnyqt3 303 3 analysis analysis NN cord-325712-9kbnyqt3 303 4 described describe VBN cord-325712-9kbnyqt3 303 5 here here RB cord-325712-9kbnyqt3 303 6 has have VBZ cord-325712-9kbnyqt3 303 7 indicated indicate VBN cord-325712-9kbnyqt3 303 8 that that IN cord-325712-9kbnyqt3 303 9 influenza influenza NN cord-325712-9kbnyqt3 303 10 virus virus NN cord-325712-9kbnyqt3 303 11 hemifusion hemifusion NN cord-325712-9kbnyqt3 303 12 is be VBZ cord-325712-9kbnyqt3 303 13 controlled control VBN cord-325712-9kbnyqt3 303 14 by by IN cord-325712-9kbnyqt3 303 15 three three CD cord-325712-9kbnyqt3 303 16 rate rate NN cord-325712-9kbnyqt3 303 17 - - HYPH cord-325712-9kbnyqt3 303 18 limiting limit VBG cord-325712-9kbnyqt3 303 19 steps step NNS cord-325712-9kbnyqt3 303 20 while while IN cord-325712-9kbnyqt3 303 21 the the DT cord-325712-9kbnyqt3 303 22 kinetics kinetic NNS cord-325712-9kbnyqt3 303 23 of of IN cord-325712-9kbnyqt3 303 24 pore pore NN cord-325712-9kbnyqt3 303 25 formation formation NN cord-325712-9kbnyqt3 303 26 is be VBZ cord-325712-9kbnyqt3 303 27 governed govern VBN cord-325712-9kbnyqt3 303 28 by by IN cord-325712-9kbnyqt3 303 29 a a DT cord-325712-9kbnyqt3 303 30 single single JJ cord-325712-9kbnyqt3 303 31 step step NN cord-325712-9kbnyqt3 303 32 [ [ -LRB- cord-325712-9kbnyqt3 303 33 33 33 CD cord-325712-9kbnyqt3 303 34 ] ] -RRB- cord-325712-9kbnyqt3 303 35 . . . cord-325712-9kbnyqt3 304 1 Chikungunya chikungunya NN cord-325712-9kbnyqt3 304 2 virus virus NN cord-325712-9kbnyqt3 304 3 also also RB cord-325712-9kbnyqt3 304 4 has have VBZ cord-325712-9kbnyqt3 304 5 three three CD cord-325712-9kbnyqt3 304 6 - - HYPH cord-325712-9kbnyqt3 304 7 rate rate NN cord-325712-9kbnyqt3 304 8 limiting limit VBG cord-325712-9kbnyqt3 304 9 steps step NNS cord-325712-9kbnyqt3 304 10 governing govern VBG cord-325712-9kbnyqt3 304 11 hemifusion hemifusion NN cord-325712-9kbnyqt3 304 12 [ [ -LRB- cord-325712-9kbnyqt3 304 13 137 137 CD cord-325712-9kbnyqt3 304 14 ] ] -RRB- cord-325712-9kbnyqt3 304 15 . . . cord-325712-9kbnyqt3 305 1 For for IN cord-325712-9kbnyqt3 305 2 West West NNP cord-325712-9kbnyqt3 305 3 Nile Nile NNP cord-325712-9kbnyqt3 305 4 virus virus NN cord-325712-9kbnyqt3 305 5 , , , cord-325712-9kbnyqt3 305 6 hemifusion hemifusion NN cord-325712-9kbnyqt3 305 7 has have VBZ cord-325712-9kbnyqt3 305 8 one one CD cord-325712-9kbnyqt3 305 9 or or CC cord-325712-9kbnyqt3 305 10 two two CD cord-325712-9kbnyqt3 305 11 rate rate NN cord-325712-9kbnyqt3 305 12 - - HYPH cord-325712-9kbnyqt3 305 13 limiting limit VBG cord-325712-9kbnyqt3 305 14 steps step NNS cord-325712-9kbnyqt3 305 15 , , , cord-325712-9kbnyqt3 305 16 depending depend VBG cord-325712-9kbnyqt3 305 17 on on IN cord-325712-9kbnyqt3 305 18 the the DT cord-325712-9kbnyqt3 305 19 pH ph NN cord-325712-9kbnyqt3 305 20 [ [ -LRB- cord-325712-9kbnyqt3 305 21 138 138 CD cord-325712-9kbnyqt3 305 22 ] ] -RRB- cord-325712-9kbnyqt3 305 23 . . . cord-325712-9kbnyqt3 306 1 Vesicular vesicular JJ cord-325712-9kbnyqt3 306 2 stomatitis stomatitis NN cord-325712-9kbnyqt3 306 3 virus virus NN cord-325712-9kbnyqt3 306 4 hemifusion hemifusion NN cord-325712-9kbnyqt3 306 5 also also RB cord-325712-9kbnyqt3 306 6 has have VBZ cord-325712-9kbnyqt3 306 7 multiple multiple JJ cord-325712-9kbnyqt3 306 8 rate rate NN cord-325712-9kbnyqt3 306 9 - - HYPH cord-325712-9kbnyqt3 306 10 limiting limit VBG cord-325712-9kbnyqt3 306 11 steps step NNS cord-325712-9kbnyqt3 306 12 at at IN cord-325712-9kbnyqt3 306 13 higher high JJR cord-325712-9kbnyqt3 306 14 pH ph NN cord-325712-9kbnyqt3 306 15 and and CC cord-325712-9kbnyqt3 306 16 a a DT cord-325712-9kbnyqt3 306 17 single single JJ cord-325712-9kbnyqt3 306 18 rate rate NN cord-325712-9kbnyqt3 306 19 - - HYPH cord-325712-9kbnyqt3 306 20 limiting limit VBG cord-325712-9kbnyqt3 306 21 step step NN cord-325712-9kbnyqt3 306 22 at at IN cord-325712-9kbnyqt3 306 23 low low JJ cord-325712-9kbnyqt3 306 24 pH pH . cord-325712-9kbnyqt3 306 25 [ [ -LRB- cord-325712-9kbnyqt3 306 26 139 139 CD cord-325712-9kbnyqt3 306 27 ] ] -RRB- cord-325712-9kbnyqt3 306 28 . . . cord-325712-9kbnyqt3 307 1 While while IN cord-325712-9kbnyqt3 307 2 it -PRON- PRP cord-325712-9kbnyqt3 307 3 can can MD cord-325712-9kbnyqt3 307 4 not not RB cord-325712-9kbnyqt3 307 5 be be VB cord-325712-9kbnyqt3 307 6 assumed assume VBN cord-325712-9kbnyqt3 307 7 that that IN cord-325712-9kbnyqt3 307 8 the the DT cord-325712-9kbnyqt3 307 9 kinetics kinetic NNS cord-325712-9kbnyqt3 307 10 obtained obtain VBN cord-325712-9kbnyqt3 307 11 from from IN cord-325712-9kbnyqt3 307 12 this this DT cord-325712-9kbnyqt3 307 13 method method NN cord-325712-9kbnyqt3 307 14 reflect reflect VBP cord-325712-9kbnyqt3 307 15 the the DT cord-325712-9kbnyqt3 307 16 actual actual JJ cord-325712-9kbnyqt3 307 17 reaction reaction NN cord-325712-9kbnyqt3 307 18 rates rate NNS cord-325712-9kbnyqt3 307 19 within within IN cord-325712-9kbnyqt3 307 20 a a DT cord-325712-9kbnyqt3 307 21 cell cell NN cord-325712-9kbnyqt3 307 22 , , , cord-325712-9kbnyqt3 307 23 comparison comparison NN cord-325712-9kbnyqt3 307 24 of of IN cord-325712-9kbnyqt3 307 25 these these DT cord-325712-9kbnyqt3 307 26 rates rate NNS cord-325712-9kbnyqt3 307 27 under under IN cord-325712-9kbnyqt3 307 28 different different JJ cord-325712-9kbnyqt3 307 29 conditions condition NNS cord-325712-9kbnyqt3 307 30 , , , cord-325712-9kbnyqt3 307 31 such such JJ cord-325712-9kbnyqt3 307 32 as as IN cord-325712-9kbnyqt3 307 33 different different JJ cord-325712-9kbnyqt3 307 34 bilayer bilayer NN cord-325712-9kbnyqt3 307 35 compositions composition NNS cord-325712-9kbnyqt3 307 36 , , , cord-325712-9kbnyqt3 307 37 pH pH NNP cord-325712-9kbnyqt3 307 38 , , , cord-325712-9kbnyqt3 307 39 or or CC cord-325712-9kbnyqt3 307 40 viral viral JJ cord-325712-9kbnyqt3 307 41 strains strain NNS cord-325712-9kbnyqt3 307 42 , , , cord-325712-9kbnyqt3 307 43 can can MD cord-325712-9kbnyqt3 307 44 yield yield VB cord-325712-9kbnyqt3 307 45 valuable valuable JJ cord-325712-9kbnyqt3 307 46 insight insight NN cord-325712-9kbnyqt3 307 47 . . . cord-325712-9kbnyqt3 308 1 The the DT cord-325712-9kbnyqt3 308 2 ability ability NN cord-325712-9kbnyqt3 308 3 to to TO cord-325712-9kbnyqt3 308 4 manipulate manipulate VB cord-325712-9kbnyqt3 308 5 the the DT cord-325712-9kbnyqt3 308 6 composition composition NN cord-325712-9kbnyqt3 308 7 of of IN cord-325712-9kbnyqt3 308 8 supported support VBN cord-325712-9kbnyqt3 308 9 lipid lipid NN cord-325712-9kbnyqt3 308 10 bilayers bilayer NNS cord-325712-9kbnyqt3 308 11 has have VBZ cord-325712-9kbnyqt3 308 12 been be VBN cord-325712-9kbnyqt3 308 13 used use VBN cord-325712-9kbnyqt3 308 14 to to TO cord-325712-9kbnyqt3 308 15 determine determine VB cord-325712-9kbnyqt3 308 16 that that IN cord-325712-9kbnyqt3 308 17 anionic anionic JJ cord-325712-9kbnyqt3 308 18 lipids lipid NNS cord-325712-9kbnyqt3 308 19 are be VBP cord-325712-9kbnyqt3 308 20 essential essential JJ cord-325712-9kbnyqt3 308 21 for for IN cord-325712-9kbnyqt3 308 22 vesicular vesicular JJ cord-325712-9kbnyqt3 308 23 stomatitis stomatitis NN cord-325712-9kbnyqt3 308 24 virus virus NN cord-325712-9kbnyqt3 308 25 fusion fusion NN cord-325712-9kbnyqt3 308 26 and and CC cord-325712-9kbnyqt3 308 27 that that IN cord-325712-9kbnyqt3 308 28 the the DT cord-325712-9kbnyqt3 308 29 lag lag NN cord-325712-9kbnyqt3 308 30 between between IN cord-325712-9kbnyqt3 308 31 hemifusion hemifusion NN cord-325712-9kbnyqt3 308 32 and and CC cord-325712-9kbnyqt3 308 33 pore pore NN cord-325712-9kbnyqt3 308 34 formation formation NN cord-325712-9kbnyqt3 308 35 is be VBZ cord-325712-9kbnyqt3 308 36 shortened shorten VBN cord-325712-9kbnyqt3 308 37 in in IN cord-325712-9kbnyqt3 308 38 the the DT cord-325712-9kbnyqt3 308 39 presence presence NN cord-325712-9kbnyqt3 308 40 of of IN cord-325712-9kbnyqt3 308 41 bis(monoacylglycero)phosphate bis(monoacylglycero)phosphate NNP cord-325712-9kbnyqt3 308 42 , , , cord-325712-9kbnyqt3 308 43 a a DT cord-325712-9kbnyqt3 308 44 lipid lipid NN cord-325712-9kbnyqt3 308 45 found find VBN cord-325712-9kbnyqt3 308 46 in in IN cord-325712-9kbnyqt3 308 47 late late JJ cord-325712-9kbnyqt3 308 48 endosomes endosome NNS cord-325712-9kbnyqt3 308 49 [ [ -LRB- cord-325712-9kbnyqt3 308 50 57 57 CD cord-325712-9kbnyqt3 308 51 ] ] -RRB- cord-325712-9kbnyqt3 308 52 . . . cord-325712-9kbnyqt3 309 1 Precisely precisely RB cord-325712-9kbnyqt3 309 2 controlling control VBG cord-325712-9kbnyqt3 309 3 the the DT cord-325712-9kbnyqt3 309 4 triggering trigger VBG cord-325712-9kbnyqt3 309 5 pH ph NN cord-325712-9kbnyqt3 309 6 has have VBZ cord-325712-9kbnyqt3 309 7 revealed reveal VBN cord-325712-9kbnyqt3 309 8 that that IN cord-325712-9kbnyqt3 309 9 influenza influenza NN cord-325712-9kbnyqt3 309 10 virus virus NN cord-325712-9kbnyqt3 309 11 requires require VBZ cord-325712-9kbnyqt3 309 12 a a DT cord-325712-9kbnyqt3 309 13 lower low JJR cord-325712-9kbnyqt3 309 14 pH ph NN cord-325712-9kbnyqt3 309 15 to to TO cord-325712-9kbnyqt3 309 16 trigger trigger VB cord-325712-9kbnyqt3 309 17 fusion fusion NN cord-325712-9kbnyqt3 309 18 than than IN cord-325712-9kbnyqt3 309 19 Sindbis Sindbis NNP cord-325712-9kbnyqt3 309 20 virus virus NN cord-325712-9kbnyqt3 309 21 [ [ -LRB- cord-325712-9kbnyqt3 309 22 34 34 CD cord-325712-9kbnyqt3 309 23 ] ] -RRB- cord-325712-9kbnyqt3 309 24 , , , cord-325712-9kbnyqt3 309 25 suggesting suggest VBG cord-325712-9kbnyqt3 309 26 that that IN cord-325712-9kbnyqt3 309 27 it -PRON- PRP cord-325712-9kbnyqt3 309 28 fuses fuse VBZ cord-325712-9kbnyqt3 309 29 later later RB cord-325712-9kbnyqt3 309 30 in in IN cord-325712-9kbnyqt3 309 31 the the DT cord-325712-9kbnyqt3 309 32 endocytic endocytic JJ cord-325712-9kbnyqt3 309 33 pathway pathway NN cord-325712-9kbnyqt3 309 34 . . . cord-325712-9kbnyqt3 310 1 While while IN cord-325712-9kbnyqt3 310 2 the the DT cord-325712-9kbnyqt3 310 3 rate rate NN cord-325712-9kbnyqt3 310 4 of of IN cord-325712-9kbnyqt3 310 5 influenza influenza NN cord-325712-9kbnyqt3 310 6 X-31 X-31 NNP cord-325712-9kbnyqt3 310 7 virus virus NN cord-325712-9kbnyqt3 310 8 hemifusion hemifusion NN cord-325712-9kbnyqt3 310 9 increases increase VBZ cord-325712-9kbnyqt3 310 10 at at IN cord-325712-9kbnyqt3 310 11 lower low JJR cord-325712-9kbnyqt3 310 12 pH pH NNP cord-325712-9kbnyqt3 310 13 [ [ -LRB- cord-325712-9kbnyqt3 310 14 33 33 CD cord-325712-9kbnyqt3 310 15 ] ] -RRB- cord-325712-9kbnyqt3 310 16 , , , cord-325712-9kbnyqt3 310 17 the the DT cord-325712-9kbnyqt3 310 18 rate rate NN cord-325712-9kbnyqt3 310 19 of of IN cord-325712-9kbnyqt3 310 20 Brisbane Brisbane NNP cord-325712-9kbnyqt3 310 21 is be VBZ cord-325712-9kbnyqt3 310 22 much much RB cord-325712-9kbnyqt3 310 23 less less JJR cord-325712-9kbnyqt3 310 24 pH ph NN cord-325712-9kbnyqt3 310 25 dependent dependent JJ cord-325712-9kbnyqt3 310 26 [ [ -LRB- cord-325712-9kbnyqt3 310 27 140 140 CD cord-325712-9kbnyqt3 310 28 ] ] -RRB- cord-325712-9kbnyqt3 310 29 . . . cord-325712-9kbnyqt3 311 1 The the DT cord-325712-9kbnyqt3 311 2 rate rate NN cord-325712-9kbnyqt3 311 3 of of IN cord-325712-9kbnyqt3 311 4 pore pore NN cord-325712-9kbnyqt3 311 5 formation formation NN cord-325712-9kbnyqt3 311 6 for for IN cord-325712-9kbnyqt3 311 7 influenza influenza NN cord-325712-9kbnyqt3 311 8 virus virus NN cord-325712-9kbnyqt3 311 9 is be VBZ cord-325712-9kbnyqt3 311 10 pH pH NNP cord-325712-9kbnyqt3 311 11 independent independent JJ cord-325712-9kbnyqt3 311 12 . . . cord-325712-9kbnyqt3 312 1 Multiple multiple JJ cord-325712-9kbnyqt3 312 2 influenza influenza NN cord-325712-9kbnyqt3 312 3 hemagglutinin hemagglutinin NN cord-325712-9kbnyqt3 312 4 trimers trimer NNS cord-325712-9kbnyqt3 312 5 are be VBP cord-325712-9kbnyqt3 312 6 involved involve VBN cord-325712-9kbnyqt3 312 7 in in IN cord-325712-9kbnyqt3 312 8 fusion fusion NN cord-325712-9kbnyqt3 312 9 [ [ -LRB- cord-325712-9kbnyqt3 312 10 141 141 CD cord-325712-9kbnyqt3 312 11 ] ] -RRB- cord-325712-9kbnyqt3 312 12 , , , cord-325712-9kbnyqt3 312 13 although although IN cord-325712-9kbnyqt3 312 14 not not RB cord-325712-9kbnyqt3 312 15 all all DT cord-325712-9kbnyqt3 312 16 are be VBP cord-325712-9kbnyqt3 312 17 active active JJ cord-325712-9kbnyqt3 312 18 participants participant NNS cord-325712-9kbnyqt3 312 19 [ [ -LRB- cord-325712-9kbnyqt3 312 20 142 142 CD cord-325712-9kbnyqt3 312 21 , , , cord-325712-9kbnyqt3 312 22 143 143 CD cord-325712-9kbnyqt3 312 23 ] ] -RRB- cord-325712-9kbnyqt3 312 24 . . . cord-325712-9kbnyqt3 313 1 This this DT cord-325712-9kbnyqt3 313 2 platform platform NN cord-325712-9kbnyqt3 313 3 is be VBZ cord-325712-9kbnyqt3 313 4 able able JJ cord-325712-9kbnyqt3 313 5 to to TO cord-325712-9kbnyqt3 313 6 detect detect VB cord-325712-9kbnyqt3 313 7 differences difference NNS cord-325712-9kbnyqt3 313 8 in in IN cord-325712-9kbnyqt3 313 9 the the DT cord-325712-9kbnyqt3 313 10 acid acid NN cord-325712-9kbnyqt3 313 11 stability stability NN cord-325712-9kbnyqt3 313 12 and and CC cord-325712-9kbnyqt3 313 13 fusion fusion NN cord-325712-9kbnyqt3 313 14 behavior behavior NN cord-325712-9kbnyqt3 313 15 of of IN cord-325712-9kbnyqt3 313 16 different different JJ cord-325712-9kbnyqt3 313 17 strains strain NNS cord-325712-9kbnyqt3 313 18 and and CC cord-325712-9kbnyqt3 313 19 reassortants reassortant NNS cord-325712-9kbnyqt3 313 20 of of IN cord-325712-9kbnyqt3 313 21 influenza influenza NN cord-325712-9kbnyqt3 313 22 , , , cord-325712-9kbnyqt3 313 23 which which WDT cord-325712-9kbnyqt3 313 24 is be VBZ cord-325712-9kbnyqt3 313 25 tied tie VBN cord-325712-9kbnyqt3 313 26 to to IN cord-325712-9kbnyqt3 313 27 their -PRON- PRP$ cord-325712-9kbnyqt3 313 28 tropism tropism NN cord-325712-9kbnyqt3 313 29 [ [ -LRB- cord-325712-9kbnyqt3 313 30 140 140 CD cord-325712-9kbnyqt3 313 31 , , , cord-325712-9kbnyqt3 313 32 144 144 CD cord-325712-9kbnyqt3 313 33 ] ] -RRB- cord-325712-9kbnyqt3 313 34 . . . cord-325712-9kbnyqt3 314 1 This this DT cord-325712-9kbnyqt3 314 2 platform platform NN cord-325712-9kbnyqt3 314 3 can can MD cord-325712-9kbnyqt3 314 4 also also RB cord-325712-9kbnyqt3 314 5 be be VB cord-325712-9kbnyqt3 314 6 used use VBN cord-325712-9kbnyqt3 314 7 to to TO cord-325712-9kbnyqt3 314 8 measure measure VB cord-325712-9kbnyqt3 314 9 the the DT cord-325712-9kbnyqt3 314 10 number number NN cord-325712-9kbnyqt3 314 11 of of IN cord-325712-9kbnyqt3 314 12 antibodies antibody NNS cord-325712-9kbnyqt3 314 13 required require VBN cord-325712-9kbnyqt3 314 14 to to TO cord-325712-9kbnyqt3 314 15 neutralize neutralize VB cord-325712-9kbnyqt3 314 16 fusion fusion NN cord-325712-9kbnyqt3 314 17 of of IN cord-325712-9kbnyqt3 314 18 a a DT cord-325712-9kbnyqt3 314 19 single single JJ cord-325712-9kbnyqt3 314 20 virion virion NN cord-325712-9kbnyqt3 314 21 [ [ -LRB- cord-325712-9kbnyqt3 314 22 145 145 CD cord-325712-9kbnyqt3 314 23 ] ] -RRB- cord-325712-9kbnyqt3 314 24 . . . cord-325712-9kbnyqt3 315 1 Figure figure NN cord-325712-9kbnyqt3 315 2 2 2 CD cord-325712-9kbnyqt3 315 3 .7 .7 NFP cord-325712-9kbnyqt3 315 4 provides provide VBZ cord-325712-9kbnyqt3 315 5 a a DT cord-325712-9kbnyqt3 315 6 summary summary NN cord-325712-9kbnyqt3 315 7 of of IN cord-325712-9kbnyqt3 315 8 the the DT cord-325712-9kbnyqt3 315 9 flexibility flexibility NN cord-325712-9kbnyqt3 315 10 , , , cord-325712-9kbnyqt3 315 11 the the DT cord-325712-9kbnyqt3 315 12 biomimetic biomimetic JJ cord-325712-9kbnyqt3 315 13 fusion fusion NN cord-325712-9kbnyqt3 315 14 assay assay NN cord-325712-9kbnyqt3 315 15 and and CC cord-325712-9kbnyqt3 315 16 the the DT cord-325712-9kbnyqt3 315 17 kinds kind NNS cord-325712-9kbnyqt3 315 18 of of IN cord-325712-9kbnyqt3 315 19 insight insight NN cord-325712-9kbnyqt3 315 20 that that WDT cord-325712-9kbnyqt3 315 21 has have VBZ cord-325712-9kbnyqt3 315 22 been be VBN cord-325712-9kbnyqt3 315 23 gained gain VBN cord-325712-9kbnyqt3 315 24 from from IN cord-325712-9kbnyqt3 315 25 these these DT cord-325712-9kbnyqt3 315 26 tunable tunable JJ cord-325712-9kbnyqt3 315 27 assays assay NNS cord-325712-9kbnyqt3 315 28 . . . cord-325712-9kbnyqt3 316 1 With with IN cord-325712-9kbnyqt3 316 2 the the DT cord-325712-9kbnyqt3 316 3 advances advance NNS cord-325712-9kbnyqt3 316 4 in in IN cord-325712-9kbnyqt3 316 5 supported support VBN cord-325712-9kbnyqt3 316 6 bilayer bilayer NN cord-325712-9kbnyqt3 316 7 complexity complexity NN cord-325712-9kbnyqt3 316 8 and and CC cord-325712-9kbnyqt3 316 9 fabrication fabrication NN cord-325712-9kbnyqt3 316 10 , , , cord-325712-9kbnyqt3 316 11 these these DT cord-325712-9kbnyqt3 316 12 platforms platform NNS cord-325712-9kbnyqt3 316 13 can can MD cord-325712-9kbnyqt3 316 14 also also RB cord-325712-9kbnyqt3 316 15 be be VB cord-325712-9kbnyqt3 316 16 used use VBN cord-325712-9kbnyqt3 316 17 to to TO cord-325712-9kbnyqt3 316 18 study study VB cord-325712-9kbnyqt3 316 19 viruses virus NNS cord-325712-9kbnyqt3 316 20 that that WDT cord-325712-9kbnyqt3 316 21 bind bind VBP cord-325712-9kbnyqt3 316 22 proteinaceous proteinaceous JJ cord-325712-9kbnyqt3 316 23 receptors receptor NNS cord-325712-9kbnyqt3 316 24 , , , cord-325712-9kbnyqt3 316 25 such such JJ cord-325712-9kbnyqt3 316 26 as as IN cord-325712-9kbnyqt3 316 27 feline feline JJ cord-325712-9kbnyqt3 316 28 coronavirus coronavirus NN cord-325712-9kbnyqt3 316 29 [ [ -LRB- cord-325712-9kbnyqt3 316 30 13 13 CD cord-325712-9kbnyqt3 316 31 ] ] -RRB- cord-325712-9kbnyqt3 316 32 . . . cord-325712-9kbnyqt3 317 1 Finally finally RB cord-325712-9kbnyqt3 317 2 , , , cord-325712-9kbnyqt3 317 3 given give VBN cord-325712-9kbnyqt3 317 4 the the DT cord-325712-9kbnyqt3 317 5 highly highly RB cord-325712-9kbnyqt3 317 6 - - HYPH cord-325712-9kbnyqt3 317 7 defined define VBN cord-325712-9kbnyqt3 317 8 nature nature NN cord-325712-9kbnyqt3 317 9 of of IN cord-325712-9kbnyqt3 317 10 these these DT cord-325712-9kbnyqt3 317 11 platforms platform NNS cord-325712-9kbnyqt3 317 12 , , , cord-325712-9kbnyqt3 317 13 viruses virus NNS cord-325712-9kbnyqt3 317 14 that that WDT cord-325712-9kbnyqt3 317 15 do do VBP cord-325712-9kbnyqt3 317 16 not not RB cord-325712-9kbnyqt3 317 17 have have VB cord-325712-9kbnyqt3 317 18 a a DT cord-325712-9kbnyqt3 317 19 known know VBN cord-325712-9kbnyqt3 317 20 fusion fusion NN cord-325712-9kbnyqt3 317 21 trigger trigger NN cord-325712-9kbnyqt3 317 22 or or CC cord-325712-9kbnyqt3 317 23 receptor receptor NN cord-325712-9kbnyqt3 317 24 might may MD cord-325712-9kbnyqt3 317 25 be be VB cord-325712-9kbnyqt3 317 26 difficult difficult JJ cord-325712-9kbnyqt3 317 27 to to TO cord-325712-9kbnyqt3 317 28 study study VB cord-325712-9kbnyqt3 317 29 , , , cord-325712-9kbnyqt3 317 30 because because IN cord-325712-9kbnyqt3 317 31 each each DT cord-325712-9kbnyqt3 317 32 component component NN cord-325712-9kbnyqt3 317 33 must must MD cord-325712-9kbnyqt3 317 34 be be VB cord-325712-9kbnyqt3 317 35 intentionally intentionally RB cord-325712-9kbnyqt3 317 36 added add VBN cord-325712-9kbnyqt3 317 37 to to IN cord-325712-9kbnyqt3 317 38 the the DT cord-325712-9kbnyqt3 317 39 platform platform NN cord-325712-9kbnyqt3 317 40 . . . cord-325712-9kbnyqt3 318 1 However however RB cord-325712-9kbnyqt3 318 2 , , , cord-325712-9kbnyqt3 318 3 because because IN cord-325712-9kbnyqt3 318 4 SLBs slb NNS cord-325712-9kbnyqt3 318 5 can can MD cord-325712-9kbnyqt3 318 6 be be VB cord-325712-9kbnyqt3 318 7 formed form VBN cord-325712-9kbnyqt3 318 8 in in IN cord-325712-9kbnyqt3 318 9 a a DT cord-325712-9kbnyqt3 318 10 microfluidic microfluidic JJ cord-325712-9kbnyqt3 318 11 device device NN cord-325712-9kbnyqt3 318 12 , , , cord-325712-9kbnyqt3 318 13 it -PRON- PRP cord-325712-9kbnyqt3 318 14 should should MD cord-325712-9kbnyqt3 318 15 be be VB cord-325712-9kbnyqt3 318 16 possible possible JJ cord-325712-9kbnyqt3 318 17 to to TO cord-325712-9kbnyqt3 318 18 formulate formulate VB cord-325712-9kbnyqt3 318 19 a a DT cord-325712-9kbnyqt3 318 20 high high JJ cord-325712-9kbnyqt3 318 21 - - HYPH cord-325712-9kbnyqt3 318 22 throughput throughput NN cord-325712-9kbnyqt3 318 23 screen screen NN cord-325712-9kbnyqt3 318 24 for for IN cord-325712-9kbnyqt3 318 25 possible possible JJ cord-325712-9kbnyqt3 318 26 fusion fusion NN cord-325712-9kbnyqt3 318 27 triggers trigger NNS cord-325712-9kbnyqt3 318 28 or or CC cord-325712-9kbnyqt3 318 29 binding bind VBG cord-325712-9kbnyqt3 318 30 partners partner NNS cord-325712-9kbnyqt3 318 31 with with IN cord-325712-9kbnyqt3 318 32 this this DT cord-325712-9kbnyqt3 318 33 configuration configuration NN cord-325712-9kbnyqt3 318 34 . . . cord-325712-9kbnyqt3 319 1 A a DT cord-325712-9kbnyqt3 319 2 common common JJ cord-325712-9kbnyqt3 319 3 method method NN cord-325712-9kbnyqt3 319 4 to to TO cord-325712-9kbnyqt3 319 5 study study VB cord-325712-9kbnyqt3 319 6 fusion fusion NN cord-325712-9kbnyqt3 319 7 behavior behavior NN cord-325712-9kbnyqt3 319 8 is be VBZ cord-325712-9kbnyqt3 319 9 cell cell NN cord-325712-9kbnyqt3 319 10 - - HYPH cord-325712-9kbnyqt3 319 11 cell cell NN cord-325712-9kbnyqt3 319 12 fusion fusion NN cord-325712-9kbnyqt3 319 13 assays assay NNS cord-325712-9kbnyqt3 319 14 , , , cord-325712-9kbnyqt3 319 15 where where WRB cord-325712-9kbnyqt3 319 16 fusion fusion NN cord-325712-9kbnyqt3 319 17 between between IN cord-325712-9kbnyqt3 319 18 target target NN cord-325712-9kbnyqt3 319 19 cells cell NNS cord-325712-9kbnyqt3 319 20 expressing express VBG cord-325712-9kbnyqt3 319 21 the the DT cord-325712-9kbnyqt3 319 22 receptor receptor NN cord-325712-9kbnyqt3 319 23 for for IN cord-325712-9kbnyqt3 319 24 the the DT cord-325712-9kbnyqt3 319 25 virus virus NN cord-325712-9kbnyqt3 319 26 and and CC cord-325712-9kbnyqt3 319 27 effector effector NN cord-325712-9kbnyqt3 319 28 cells cell NNS cord-325712-9kbnyqt3 319 29 expressing express VBG cord-325712-9kbnyqt3 319 30 the the DT cord-325712-9kbnyqt3 319 31 viral viral JJ cord-325712-9kbnyqt3 319 32 fusion fusion NN cord-325712-9kbnyqt3 319 33 protein protein NN cord-325712-9kbnyqt3 319 34 is be VBZ cord-325712-9kbnyqt3 319 35 monitored monitor VBN cord-325712-9kbnyqt3 319 36 . . . cord-325712-9kbnyqt3 320 1 When when WRB cord-325712-9kbnyqt3 320 2 the the DT cord-325712-9kbnyqt3 320 3 viral viral JJ cord-325712-9kbnyqt3 320 4 fusion fusion NN cord-325712-9kbnyqt3 320 5 protein protein NN cord-325712-9kbnyqt3 320 6 is be VBZ cord-325712-9kbnyqt3 320 7 triggered trigger VBN cord-325712-9kbnyqt3 320 8 , , , cord-325712-9kbnyqt3 320 9 for for IN cord-325712-9kbnyqt3 320 10 example example NN cord-325712-9kbnyqt3 320 11 by by IN cord-325712-9kbnyqt3 320 12 lowering lower VBG cord-325712-9kbnyqt3 320 13 the the DT cord-325712-9kbnyqt3 320 14 pH pH NNP cord-325712-9kbnyqt3 320 15 , , , cord-325712-9kbnyqt3 320 16 the the DT cord-325712-9kbnyqt3 320 17 cells cell NNS cord-325712-9kbnyqt3 320 18 fuse fuse VBP cord-325712-9kbnyqt3 320 19 to to IN cord-325712-9kbnyqt3 320 20 each each DT cord-325712-9kbnyqt3 320 21 other other JJ cord-325712-9kbnyqt3 320 22 , , , cord-325712-9kbnyqt3 320 23 leading lead VBG cord-325712-9kbnyqt3 320 24 to to IN cord-325712-9kbnyqt3 320 25 clusters cluster NNS cord-325712-9kbnyqt3 320 26 of of IN cord-325712-9kbnyqt3 320 27 multiple multiple JJ cord-325712-9kbnyqt3 320 28 nuclei nucleus NNS cord-325712-9kbnyqt3 320 29 surrounded surround VBN cord-325712-9kbnyqt3 320 30 by by IN cord-325712-9kbnyqt3 320 31 a a DT cord-325712-9kbnyqt3 320 32 single single JJ cord-325712-9kbnyqt3 320 33 cell cell NN cord-325712-9kbnyqt3 320 34 membrane membrane NN cord-325712-9kbnyqt3 320 35 [ [ -LRB- cord-325712-9kbnyqt3 320 36 146 146 CD cord-325712-9kbnyqt3 320 37 ] ] -RRB- cord-325712-9kbnyqt3 320 38 . . . cord-325712-9kbnyqt3 321 1 These these DT cord-325712-9kbnyqt3 321 2 clusters cluster NNS cord-325712-9kbnyqt3 321 3 are be VBP cord-325712-9kbnyqt3 321 4 known know VBN cord-325712-9kbnyqt3 321 5 as as IN cord-325712-9kbnyqt3 321 6 syncytia syncytia NN cord-325712-9kbnyqt3 321 7 . . . cord-325712-9kbnyqt3 322 1 Lipophilic lipophilic JJ cord-325712-9kbnyqt3 322 2 and and CC cord-325712-9kbnyqt3 322 3 aqueous aqueous JJ cord-325712-9kbnyqt3 322 4 dyes dye NNS cord-325712-9kbnyqt3 322 5 can can MD cord-325712-9kbnyqt3 322 6 be be VB cord-325712-9kbnyqt3 322 7 used use VBN cord-325712-9kbnyqt3 322 8 to to TO cord-325712-9kbnyqt3 322 9 label label VB cord-325712-9kbnyqt3 322 10 the the DT cord-325712-9kbnyqt3 322 11 membrane membrane NN cord-325712-9kbnyqt3 322 12 and and CC cord-325712-9kbnyqt3 322 13 contents content NNS cord-325712-9kbnyqt3 322 14 of of IN cord-325712-9kbnyqt3 322 15 the the DT cord-325712-9kbnyqt3 322 16 effector effector NN cord-325712-9kbnyqt3 322 17 cell cell NN cord-325712-9kbnyqt3 322 18 , , , cord-325712-9kbnyqt3 322 19 providing provide VBG cord-325712-9kbnyqt3 322 20 readouts readout NNS cord-325712-9kbnyqt3 322 21 for for IN cord-325712-9kbnyqt3 322 22 lipid lipid NN cord-325712-9kbnyqt3 322 23 mixing mixing NN cord-325712-9kbnyqt3 322 24 or or CC cord-325712-9kbnyqt3 322 25 pore pore NN cord-325712-9kbnyqt3 322 26 formation formation NN cord-325712-9kbnyqt3 322 27 . . . cord-325712-9kbnyqt3 323 1 To to TO cord-325712-9kbnyqt3 323 2 isolate isolate VB cord-325712-9kbnyqt3 323 3 the the DT cord-325712-9kbnyqt3 323 4 hemifusion hemifusion NN cord-325712-9kbnyqt3 323 5 step step NN cord-325712-9kbnyqt3 323 6 , , , cord-325712-9kbnyqt3 323 7 fusion fusion NN cord-325712-9kbnyqt3 323 8 can can MD cord-325712-9kbnyqt3 323 9 be be VB cord-325712-9kbnyqt3 323 10 triggered trigger VBN cord-325712-9kbnyqt3 323 11 then then RB cord-325712-9kbnyqt3 323 12 arrested arrest VBN cord-325712-9kbnyqt3 323 13 by by IN cord-325712-9kbnyqt3 323 14 quickly quickly RB cord-325712-9kbnyqt3 323 15 cooling cool VBG cord-325712-9kbnyqt3 323 16 the the DT cord-325712-9kbnyqt3 323 17 cells cell NNS cord-325712-9kbnyqt3 323 18 to to IN cord-325712-9kbnyqt3 323 19 4 4 CD cord-325712-9kbnyqt3 323 20 C C NNP cord-325712-9kbnyqt3 323 21 [ [ -LRB- cord-325712-9kbnyqt3 323 22 147 147 CD cord-325712-9kbnyqt3 323 23 , , , cord-325712-9kbnyqt3 323 24 148 148 CD cord-325712-9kbnyqt3 323 25 ] ] -RRB- cord-325712-9kbnyqt3 323 26 . . . cord-325712-9kbnyqt3 324 1 This this DT cord-325712-9kbnyqt3 324 2 rapid rapid RB cord-325712-9kbnyqt3 324 3 - - HYPH cord-325712-9kbnyqt3 324 4 cooling cool VBG cord-325712-9kbnyqt3 324 5 approach approach NN cord-325712-9kbnyqt3 324 6 has have VBZ cord-325712-9kbnyqt3 324 7 been be VBN cord-325712-9kbnyqt3 324 8 used use VBN cord-325712-9kbnyqt3 324 9 to to TO cord-325712-9kbnyqt3 324 10 determine determine VB cord-325712-9kbnyqt3 324 11 that that DT cord-325712-9kbnyqt3 324 12 hemifusion hemifusion NN cord-325712-9kbnyqt3 324 13 of of IN cord-325712-9kbnyqt3 324 14 avian avian JJ cord-325712-9kbnyqt3 324 15 sarcoma sarcoma NN cord-325712-9kbnyqt3 324 16 and and CC cord-325712-9kbnyqt3 324 17 leukosis leukosis NN cord-325712-9kbnyqt3 324 18 virus virus NN cord-325712-9kbnyqt3 324 19 requires require VBZ cord-325712-9kbnyqt3 324 20 low low JJ cord-325712-9kbnyqt3 324 21 pH ph NN cord-325712-9kbnyqt3 324 22 , , , cord-325712-9kbnyqt3 324 23 but but CC cord-325712-9kbnyqt3 324 24 expansion expansion NN cord-325712-9kbnyqt3 324 25 of of IN cord-325712-9kbnyqt3 324 26 the the DT cord-325712-9kbnyqt3 324 27 fusion fusion NN cord-325712-9kbnyqt3 324 28 pore pore NN cord-325712-9kbnyqt3 324 29 does do VBZ cord-325712-9kbnyqt3 324 30 not not RB cord-325712-9kbnyqt3 324 31 [ [ -LRB- cord-325712-9kbnyqt3 324 32 148 148 CD cord-325712-9kbnyqt3 324 33 ] ] -RRB- cord-325712-9kbnyqt3 324 34 . . . cord-325712-9kbnyqt3 325 1 As as IN cord-325712-9kbnyqt3 325 2 an an DT cord-325712-9kbnyqt3 325 3 alternative alternative NN cord-325712-9kbnyqt3 325 4 to to IN cord-325712-9kbnyqt3 325 5 monitoring monitor VBG cord-325712-9kbnyqt3 325 6 pore pore NN cord-325712-9kbnyqt3 325 7 formation formation NN cord-325712-9kbnyqt3 325 8 by by IN cord-325712-9kbnyqt3 325 9 observing observe VBG cord-325712-9kbnyqt3 325 10 the the DT cord-325712-9kbnyqt3 325 11 transfer transfer NN cord-325712-9kbnyqt3 325 12 of of IN cord-325712-9kbnyqt3 325 13 intracellular intracellular JJ cord-325712-9kbnyqt3 325 14 fluorescent fluorescent JJ cord-325712-9kbnyqt3 325 15 cargo cargo NN cord-325712-9kbnyqt3 325 16 from from IN cord-325712-9kbnyqt3 325 17 effector effector NN cord-325712-9kbnyqt3 325 18 cells cell NNS cord-325712-9kbnyqt3 325 19 to to TO cord-325712-9kbnyqt3 325 20 target target VB cord-325712-9kbnyqt3 325 21 cells cell NNS cord-325712-9kbnyqt3 325 22 [ [ -LRB- cord-325712-9kbnyqt3 325 23 149 149 CD cord-325712-9kbnyqt3 325 24 ] ] -RRB- cord-325712-9kbnyqt3 325 25 , , , cord-325712-9kbnyqt3 325 26 whole whole JJ cord-325712-9kbnyqt3 325 27 cell cell NN cord-325712-9kbnyqt3 325 28 patch patch NN cord-325712-9kbnyqt3 325 29 - - HYPH cord-325712-9kbnyqt3 325 30 clamp clamp NN cord-325712-9kbnyqt3 325 31 electrical electrical JJ cord-325712-9kbnyqt3 325 32 measurements measurement NNS cord-325712-9kbnyqt3 325 33 can can MD cord-325712-9kbnyqt3 325 34 be be VB cord-325712-9kbnyqt3 325 35 used use VBN cord-325712-9kbnyqt3 325 36 [ [ -LRB- cord-325712-9kbnyqt3 325 37 150 150 CD cord-325712-9kbnyqt3 325 38 ] ] -RRB- cord-325712-9kbnyqt3 325 39 . . . cord-325712-9kbnyqt3 326 1 In in IN cord-325712-9kbnyqt3 326 2 this this DT cord-325712-9kbnyqt3 326 3 configuration configuration NN cord-325712-9kbnyqt3 326 4 , , , cord-325712-9kbnyqt3 326 5 a a DT cord-325712-9kbnyqt3 326 6 pipette pipette NN cord-325712-9kbnyqt3 326 7 connected connect VBN cord-325712-9kbnyqt3 326 8 to to IN cord-325712-9kbnyqt3 326 9 an an DT cord-325712-9kbnyqt3 326 10 electrode electrode NN cord-325712-9kbnyqt3 326 11 and and CC cord-325712-9kbnyqt3 326 12 amplifier amplifier NN cord-325712-9kbnyqt3 326 13 pierces pierce VBZ cord-325712-9kbnyqt3 326 14 the the DT cord-325712-9kbnyqt3 326 15 membrane membrane NN cord-325712-9kbnyqt3 326 16 of of IN cord-325712-9kbnyqt3 326 17 the the DT cord-325712-9kbnyqt3 326 18 effector effector NN cord-325712-9kbnyqt3 326 19 cell cell NN cord-325712-9kbnyqt3 326 20 . . . cord-325712-9kbnyqt3 327 1 The the DT cord-325712-9kbnyqt3 327 2 voltage voltage NN cord-325712-9kbnyqt3 327 3 across across IN cord-325712-9kbnyqt3 327 4 the the DT cord-325712-9kbnyqt3 327 5 membrane membrane NN cord-325712-9kbnyqt3 327 6 can can MD cord-325712-9kbnyqt3 327 7 be be VB cord-325712-9kbnyqt3 327 8 manipulated manipulate VBN cord-325712-9kbnyqt3 327 9 and and CC cord-325712-9kbnyqt3 327 10 the the DT cord-325712-9kbnyqt3 327 11 resulting result VBG cord-325712-9kbnyqt3 327 12 current current NN cord-325712-9kbnyqt3 327 13 measured measure VBN cord-325712-9kbnyqt3 327 14 . . . cord-325712-9kbnyqt3 328 1 During during IN cord-325712-9kbnyqt3 328 2 cellcell cellcell NNP cord-325712-9kbnyqt3 328 3 fusion fusion NN cord-325712-9kbnyqt3 328 4 , , , cord-325712-9kbnyqt3 328 5 the the DT cord-325712-9kbnyqt3 328 6 cell cell NN cord-325712-9kbnyqt3 328 7 surface surface NN cord-325712-9kbnyqt3 328 8 area area NN cord-325712-9kbnyqt3 328 9 increases increase NNS cord-325712-9kbnyqt3 328 10 as as IN cord-325712-9kbnyqt3 328 11 the the DT cord-325712-9kbnyqt3 328 12 membranes membrane NNS cord-325712-9kbnyqt3 328 13 merge merge VBP cord-325712-9kbnyqt3 328 14 , , , cord-325712-9kbnyqt3 328 15 resulting result VBG cord-325712-9kbnyqt3 328 16 in in IN cord-325712-9kbnyqt3 328 17 an an DT cord-325712-9kbnyqt3 328 18 increase increase NN cord-325712-9kbnyqt3 328 19 in in IN cord-325712-9kbnyqt3 328 20 membrane membrane NN cord-325712-9kbnyqt3 328 21 capacitance capacitance NN cord-325712-9kbnyqt3 328 22 . . . cord-325712-9kbnyqt3 329 1 Such such JJ cord-325712-9kbnyqt3 329 2 measurements measurement NNS cord-325712-9kbnyqt3 329 3 can can MD cord-325712-9kbnyqt3 329 4 also also RB cord-325712-9kbnyqt3 329 5 allow allow VB cord-325712-9kbnyqt3 329 6 for for IN cord-325712-9kbnyqt3 329 7 estimation estimation NN cord-325712-9kbnyqt3 329 8 of of IN cord-325712-9kbnyqt3 329 9 fusion fusion NN cord-325712-9kbnyqt3 329 10 pore pore NN cord-325712-9kbnyqt3 329 11 size size NN cord-325712-9kbnyqt3 329 12 [ [ -LRB- cord-325712-9kbnyqt3 329 13 151 151 CD cord-325712-9kbnyqt3 329 14 ] ] -RRB- cord-325712-9kbnyqt3 329 15 . . . cord-325712-9kbnyqt3 330 1 While while IN cord-325712-9kbnyqt3 330 2 syncytia syncytia NN cord-325712-9kbnyqt3 330 3 assays assay NNS cord-325712-9kbnyqt3 330 4 do do VBP cord-325712-9kbnyqt3 330 5 not not RB cord-325712-9kbnyqt3 330 6 require require VB cord-325712-9kbnyqt3 330 7 viral viral JJ cord-325712-9kbnyqt3 330 8 particles particle NNS cord-325712-9kbnyqt3 330 9 or or CC cord-325712-9kbnyqt3 330 10 specialized specialized JJ cord-325712-9kbnyqt3 330 11 equipment equipment NN cord-325712-9kbnyqt3 330 12 , , , cord-325712-9kbnyqt3 330 13 making make VBG cord-325712-9kbnyqt3 330 14 them -PRON- PRP cord-325712-9kbnyqt3 330 15 easy easy JJ cord-325712-9kbnyqt3 330 16 to to TO cord-325712-9kbnyqt3 330 17 carry carry VB cord-325712-9kbnyqt3 330 18 out out RP cord-325712-9kbnyqt3 330 19 , , , cord-325712-9kbnyqt3 330 20 there there EX cord-325712-9kbnyqt3 330 21 are be VBP cord-325712-9kbnyqt3 330 22 some some DT cord-325712-9kbnyqt3 330 23 limitations limitation NNS cord-325712-9kbnyqt3 330 24 . . . cord-325712-9kbnyqt3 331 1 Syncytia syncytia NN cord-325712-9kbnyqt3 331 2 form form NN cord-325712-9kbnyqt3 331 3 over over IN cord-325712-9kbnyqt3 331 4 the the DT cord-325712-9kbnyqt3 331 5 course course NN cord-325712-9kbnyqt3 331 6 of of IN cord-325712-9kbnyqt3 331 7 hours hour NNS cord-325712-9kbnyqt3 331 8 , , , cord-325712-9kbnyqt3 331 9 so so CC cord-325712-9kbnyqt3 331 10 this this DT cord-325712-9kbnyqt3 331 11 technique technique NN cord-325712-9kbnyqt3 331 12 is be VBZ cord-325712-9kbnyqt3 331 13 not not RB cord-325712-9kbnyqt3 331 14 suitable suitable JJ cord-325712-9kbnyqt3 331 15 for for IN cord-325712-9kbnyqt3 331 16 obtaining obtain VBG cord-325712-9kbnyqt3 331 17 kinetic kinetic JJ cord-325712-9kbnyqt3 331 18 data datum NNS cord-325712-9kbnyqt3 331 19 Features feature NNS cord-325712-9kbnyqt3 331 20 that that WDT cord-325712-9kbnyqt3 331 21 can can MD cord-325712-9kbnyqt3 331 22 be be VB cord-325712-9kbnyqt3 331 23 easily easily RB cord-325712-9kbnyqt3 331 24 controlled control VBN cord-325712-9kbnyqt3 331 25 in in IN cord-325712-9kbnyqt3 331 26 biomimetic biomimetic JJ cord-325712-9kbnyqt3 331 27 fusion fusion NN cord-325712-9kbnyqt3 331 28 assays assay NNS cord-325712-9kbnyqt3 331 29 . . . cord-325712-9kbnyqt3 332 1 In in IN cord-325712-9kbnyqt3 332 2 combination combination NN cord-325712-9kbnyqt3 332 3 with with IN cord-325712-9kbnyqt3 332 4 a a DT cord-325712-9kbnyqt3 332 5 high high JJ cord-325712-9kbnyqt3 332 6 throughput throughput NN cord-325712-9kbnyqt3 332 7 approach approach NN cord-325712-9kbnyqt3 332 8 , , , cord-325712-9kbnyqt3 332 9 these these DT cord-325712-9kbnyqt3 332 10 conditions condition NNS cord-325712-9kbnyqt3 332 11 ( ( -LRB- cord-325712-9kbnyqt3 332 12 left left NN cord-325712-9kbnyqt3 332 13 ) ) -RRB- cord-325712-9kbnyqt3 332 14 can can MD cord-325712-9kbnyqt3 332 15 be be VB cord-325712-9kbnyqt3 332 16 evaluated evaluate VBN cord-325712-9kbnyqt3 332 17 to to TO cord-325712-9kbnyqt3 332 18 provide provide VB cord-325712-9kbnyqt3 332 19 new new JJ cord-325712-9kbnyqt3 332 20 insight insight NN cord-325712-9kbnyqt3 332 21 into into IN cord-325712-9kbnyqt3 332 22 virus virus NN cord-325712-9kbnyqt3 332 23 fusion fusion NN cord-325712-9kbnyqt3 332 24 . . . cord-325712-9kbnyqt3 333 1 ( ( -LRB- cord-325712-9kbnyqt3 333 2 Right right JJ cord-325712-9kbnyqt3 333 3 ) ) -RRB- cord-325712-9kbnyqt3 333 4 Examples example NNS cord-325712-9kbnyqt3 333 5 of of IN cord-325712-9kbnyqt3 333 6 the the DT cord-325712-9kbnyqt3 333 7 kinds kind NNS cord-325712-9kbnyqt3 333 8 of of IN cord-325712-9kbnyqt3 333 9 insight insight NN cord-325712-9kbnyqt3 333 10 that that WDT cord-325712-9kbnyqt3 333 11 can can MD cord-325712-9kbnyqt3 333 12 be be VB cord-325712-9kbnyqt3 333 13 gained gain VBN cord-325712-9kbnyqt3 333 14 with with IN cord-325712-9kbnyqt3 333 15 a a DT cord-325712-9kbnyqt3 333 16 biomimetic biomimetic JJ cord-325712-9kbnyqt3 333 17 assay assay NN cord-325712-9kbnyqt3 333 18 that that WDT cord-325712-9kbnyqt3 333 19 isolates isolate VBZ cord-325712-9kbnyqt3 333 20 the the DT cord-325712-9kbnyqt3 333 21 fusion fusion NN cord-325712-9kbnyqt3 333 22 reaction reaction NN cord-325712-9kbnyqt3 333 23 from from IN cord-325712-9kbnyqt3 333 24 other other JJ cord-325712-9kbnyqt3 333 25 virus virus NN cord-325712-9kbnyqt3 333 26 entry entry NN cord-325712-9kbnyqt3 333 27 steps step NNS cord-325712-9kbnyqt3 333 28 [ [ -LRB- cord-325712-9kbnyqt3 333 29 152 152 CD cord-325712-9kbnyqt3 333 30 ] ] -RRB- cord-325712-9kbnyqt3 333 31 . . . cord-325712-9kbnyqt3 334 1 Furthermore furthermore RB cord-325712-9kbnyqt3 334 2 , , , cord-325712-9kbnyqt3 334 3 the the DT cord-325712-9kbnyqt3 334 4 extracellular extracellular JJ cord-325712-9kbnyqt3 334 5 environment environment NN cord-325712-9kbnyqt3 334 6 can can MD cord-325712-9kbnyqt3 334 7 differ differ VB cord-325712-9kbnyqt3 334 8 substantially substantially RB cord-325712-9kbnyqt3 334 9 from from IN cord-325712-9kbnyqt3 334 10 the the DT cord-325712-9kbnyqt3 334 11 endosomal endosomal NNP cord-325712-9kbnyqt3 334 12 environment environment NN cord-325712-9kbnyqt3 334 13 , , , cord-325712-9kbnyqt3 334 14 which which WDT cord-325712-9kbnyqt3 334 15 may may MD cord-325712-9kbnyqt3 334 16 create create VB cord-325712-9kbnyqt3 334 17 artifacts artifact NNS cord-325712-9kbnyqt3 334 18 when when WRB cord-325712-9kbnyqt3 334 19 using use VBG cord-325712-9kbnyqt3 334 20 this this DT cord-325712-9kbnyqt3 334 21 technique technique NN cord-325712-9kbnyqt3 334 22 to to TO cord-325712-9kbnyqt3 334 23 study study VB cord-325712-9kbnyqt3 334 24 viruses virus NNS cord-325712-9kbnyqt3 334 25 that that WDT cord-325712-9kbnyqt3 334 26 typically typically RB cord-325712-9kbnyqt3 334 27 fuse fuse VBP cord-325712-9kbnyqt3 334 28 within within IN cord-325712-9kbnyqt3 334 29 the the DT cord-325712-9kbnyqt3 334 30 endocytic endocytic JJ cord-325712-9kbnyqt3 334 31 pathway pathway NN cord-325712-9kbnyqt3 334 32 . . . cord-325712-9kbnyqt3 335 1 In in IN cord-325712-9kbnyqt3 335 2 this this DT cord-325712-9kbnyqt3 335 3 approach approach NN cord-325712-9kbnyqt3 335 4 , , , cord-325712-9kbnyqt3 335 5 any any DT cord-325712-9kbnyqt3 335 6 impact impact NN cord-325712-9kbnyqt3 335 7 of of IN cord-325712-9kbnyqt3 335 8 the the DT cord-325712-9kbnyqt3 335 9 virion virion NN cord-325712-9kbnyqt3 335 10 size size NN cord-325712-9kbnyqt3 335 11 or or CC cord-325712-9kbnyqt3 335 12 shape shape NN cord-325712-9kbnyqt3 335 13 on on IN cord-325712-9kbnyqt3 335 14 fusion fusion NN cord-325712-9kbnyqt3 335 15 is be VBZ cord-325712-9kbnyqt3 335 16 not not RB cord-325712-9kbnyqt3 335 17 captured capture VBN cord-325712-9kbnyqt3 335 18 . . . cord-325712-9kbnyqt3 336 1 In in IN cord-325712-9kbnyqt3 336 2 bulk bulk JJ cord-325712-9kbnyqt3 336 3 fusion fusion NN cord-325712-9kbnyqt3 336 4 assays assay NNS cord-325712-9kbnyqt3 336 5 , , , cord-325712-9kbnyqt3 336 6 viral viral JJ cord-325712-9kbnyqt3 336 7 particles particle NNS cord-325712-9kbnyqt3 336 8 are be VBP cord-325712-9kbnyqt3 336 9 fluorescently fluorescently RB cord-325712-9kbnyqt3 336 10 labeled label VBN cord-325712-9kbnyqt3 336 11 , , , cord-325712-9kbnyqt3 336 12 then then RB cord-325712-9kbnyqt3 336 13 they -PRON- PRP cord-325712-9kbnyqt3 336 14 are be VBP cord-325712-9kbnyqt3 336 15 mixed mix VBN cord-325712-9kbnyqt3 336 16 with with IN cord-325712-9kbnyqt3 336 17 liposomes liposome NNS cord-325712-9kbnyqt3 336 18 in in IN cord-325712-9kbnyqt3 336 19 a a DT cord-325712-9kbnyqt3 336 20 cuvette cuvette NN cord-325712-9kbnyqt3 336 21 and and CC cord-325712-9kbnyqt3 336 22 the the DT cord-325712-9kbnyqt3 336 23 fluorescent fluorescent JJ cord-325712-9kbnyqt3 336 24 signal signal NN cord-325712-9kbnyqt3 336 25 of of IN cord-325712-9kbnyqt3 336 26 the the DT cord-325712-9kbnyqt3 336 27 solution solution NN cord-325712-9kbnyqt3 336 28 is be VBZ cord-325712-9kbnyqt3 336 29 measured measure VBN cord-325712-9kbnyqt3 336 30 by by IN cord-325712-9kbnyqt3 336 31 fluorimetry fluorimetry NNP cord-325712-9kbnyqt3 336 32 as as IN cord-325712-9kbnyqt3 336 33 fusion fusion NN cord-325712-9kbnyqt3 336 34 triggers trigger NNS cord-325712-9kbnyqt3 336 35 are be VBP cord-325712-9kbnyqt3 336 36 added add VBN cord-325712-9kbnyqt3 336 37 . . . cord-325712-9kbnyqt3 337 1 In in IN cord-325712-9kbnyqt3 337 2 one one CD cord-325712-9kbnyqt3 337 3 labeling labeling NN cord-325712-9kbnyqt3 337 4 approach approach NN cord-325712-9kbnyqt3 337 5 , , , cord-325712-9kbnyqt3 337 6 particles particle NNS cord-325712-9kbnyqt3 337 7 and/or and/or CC cord-325712-9kbnyqt3 337 8 liposome liposome NN cord-325712-9kbnyqt3 337 9 membranes membrane NNS cord-325712-9kbnyqt3 337 10 can can MD cord-325712-9kbnyqt3 337 11 be be VB cord-325712-9kbnyqt3 337 12 labeled label VBN cord-325712-9kbnyqt3 337 13 with with IN cord-325712-9kbnyqt3 337 14 fluorescence fluorescence NN cord-325712-9kbnyqt3 337 15 energy energy NN cord-325712-9kbnyqt3 337 16 resonance resonance NN cord-325712-9kbnyqt3 337 17 transfer transfer NN cord-325712-9kbnyqt3 337 18 ( ( -LRB- cord-325712-9kbnyqt3 337 19 FRET fret NN cord-325712-9kbnyqt3 337 20 ) ) -RRB- cord-325712-9kbnyqt3 337 21 pairs pair NNS cord-325712-9kbnyqt3 337 22 . . . cord-325712-9kbnyqt3 338 1 If if IN cord-325712-9kbnyqt3 338 2 fusion fusion NN cord-325712-9kbnyqt3 338 3 occurs occur VBZ cord-325712-9kbnyqt3 338 4 , , , cord-325712-9kbnyqt3 338 5 FRET FRET NNP cord-325712-9kbnyqt3 338 6 will will MD cord-325712-9kbnyqt3 338 7 stop stop VB cord-325712-9kbnyqt3 338 8 as as IN cord-325712-9kbnyqt3 338 9 the the DT cord-325712-9kbnyqt3 338 10 pairs pair NNS cord-325712-9kbnyqt3 338 11 become become VBP cord-325712-9kbnyqt3 338 12 separated separate VBN cord-325712-9kbnyqt3 338 13 , , , cord-325712-9kbnyqt3 338 14 and and CC cord-325712-9kbnyqt3 338 15 the the DT cord-325712-9kbnyqt3 338 16 fluorescence fluorescence NN cord-325712-9kbnyqt3 338 17 signal signal NN cord-325712-9kbnyqt3 338 18 will will MD cord-325712-9kbnyqt3 338 19 change change VB cord-325712-9kbnyqt3 338 20 accordingly accordingly RB cord-325712-9kbnyqt3 338 21 [ [ -LRB- cord-325712-9kbnyqt3 338 22 153 153 CD cord-325712-9kbnyqt3 338 23 ] ] -RRB- cord-325712-9kbnyqt3 338 24 . . . cord-325712-9kbnyqt3 339 1 In in IN cord-325712-9kbnyqt3 339 2 the the DT cord-325712-9kbnyqt3 339 3 second second JJ cord-325712-9kbnyqt3 339 4 labeling labeling NN cord-325712-9kbnyqt3 339 5 approach approach NN cord-325712-9kbnyqt3 339 6 , , , cord-325712-9kbnyqt3 339 7 particle particle NN cord-325712-9kbnyqt3 339 8 membranes membrane NNS cord-325712-9kbnyqt3 339 9 are be VBP cord-325712-9kbnyqt3 339 10 labeled label VBN cord-325712-9kbnyqt3 339 11 with with IN cord-325712-9kbnyqt3 339 12 a a DT cord-325712-9kbnyqt3 339 13 single single JJ cord-325712-9kbnyqt3 339 14 quenched quench VBN cord-325712-9kbnyqt3 339 15 fluorescent fluorescent NN cord-325712-9kbnyqt3 339 16 marker marker NN cord-325712-9kbnyqt3 339 17 [ [ -LRB- cord-325712-9kbnyqt3 339 18 154 154 CD cord-325712-9kbnyqt3 339 19 ] ] -RRB- cord-325712-9kbnyqt3 339 20 . . . cord-325712-9kbnyqt3 340 1 Upon upon IN cord-325712-9kbnyqt3 340 2 fusion fusion NN cord-325712-9kbnyqt3 340 3 with with IN cord-325712-9kbnyqt3 340 4 a a DT cord-325712-9kbnyqt3 340 5 liposome liposome NN cord-325712-9kbnyqt3 340 6 , , , cord-325712-9kbnyqt3 340 7 the the DT cord-325712-9kbnyqt3 340 8 quenched quench VBN cord-325712-9kbnyqt3 340 9 fluorophores fluorophore NNS cord-325712-9kbnyqt3 340 10 will will MD cord-325712-9kbnyqt3 340 11 become become VB cord-325712-9kbnyqt3 340 12 diluted dilute VBN cord-325712-9kbnyqt3 340 13 and and CC cord-325712-9kbnyqt3 340 14 dequench dequench NNP cord-325712-9kbnyqt3 340 15 , , , cord-325712-9kbnyqt3 340 16 causing cause VBG cord-325712-9kbnyqt3 340 17 a a DT cord-325712-9kbnyqt3 340 18 marked marked JJ cord-325712-9kbnyqt3 340 19 increase increase NN cord-325712-9kbnyqt3 340 20 in in IN cord-325712-9kbnyqt3 340 21 fluorescence fluorescence NN cord-325712-9kbnyqt3 340 22 . . . cord-325712-9kbnyqt3 341 1 In in IN cord-325712-9kbnyqt3 341 2 a a DT cord-325712-9kbnyqt3 341 3 third third JJ cord-325712-9kbnyqt3 341 4 approach approach NN cord-325712-9kbnyqt3 341 5 , , , cord-325712-9kbnyqt3 341 6 the the DT cord-325712-9kbnyqt3 341 7 release release NN cord-325712-9kbnyqt3 341 8 of of IN cord-325712-9kbnyqt3 341 9 viral viral JJ cord-325712-9kbnyqt3 341 10 cargo cargo NN cord-325712-9kbnyqt3 341 11 can can MD cord-325712-9kbnyqt3 341 12 be be VB cord-325712-9kbnyqt3 341 13 detected detect VBN cord-325712-9kbnyqt3 341 14 by by IN cord-325712-9kbnyqt3 341 15 measuring measure VBG cord-325712-9kbnyqt3 341 16 β β NN cord-325712-9kbnyqt3 341 17 - - HYPH cord-325712-9kbnyqt3 341 18 lactamase lactamase NNP cord-325712-9kbnyqt3 341 19 ( ( -LRB- cord-325712-9kbnyqt3 341 20 BlaM BlaM NNP cord-325712-9kbnyqt3 341 21 ) ) -RRB- cord-325712-9kbnyqt3 341 22 activity activity NN cord-325712-9kbnyqt3 341 23 . . . cord-325712-9kbnyqt3 342 1 In in IN cord-325712-9kbnyqt3 342 2 this this DT cord-325712-9kbnyqt3 342 3 type type NN cord-325712-9kbnyqt3 342 4 of of IN cord-325712-9kbnyqt3 342 5 assay assay NN cord-325712-9kbnyqt3 342 6 , , , cord-325712-9kbnyqt3 342 7 target target NN cord-325712-9kbnyqt3 342 8 cells cell NNS cord-325712-9kbnyqt3 342 9 are be VBP cord-325712-9kbnyqt3 342 10 loaded load VBN cord-325712-9kbnyqt3 342 11 with with IN cord-325712-9kbnyqt3 342 12 a a DT cord-325712-9kbnyqt3 342 13 dye dye NN cord-325712-9kbnyqt3 342 14 containing contain VBG cord-325712-9kbnyqt3 342 15 a a DT cord-325712-9kbnyqt3 342 16 β β NN cord-325712-9kbnyqt3 342 17 - - HYPH cord-325712-9kbnyqt3 342 18 lactam lactam NN cord-325712-9kbnyqt3 342 19 ring ring NN cord-325712-9kbnyqt3 342 20 and and CC cord-325712-9kbnyqt3 342 21 a a DT cord-325712-9kbnyqt3 342 22 FRET fret NN cord-325712-9kbnyqt3 342 23 pair pair NN cord-325712-9kbnyqt3 342 24 . . . cord-325712-9kbnyqt3 343 1 Chimeras chimera NNS cord-325712-9kbnyqt3 343 2 of of IN cord-325712-9kbnyqt3 343 3 viral viral JJ cord-325712-9kbnyqt3 343 4 core core NN cord-325712-9kbnyqt3 343 5 proteins protein NNS cord-325712-9kbnyqt3 343 6 and and CC cord-325712-9kbnyqt3 343 7 BlaM BlaM NNP cord-325712-9kbnyqt3 343 8 are be VBP cord-325712-9kbnyqt3 343 9 incorporated incorporate VBN cord-325712-9kbnyqt3 343 10 into into IN cord-325712-9kbnyqt3 343 11 virions virion NNS cord-325712-9kbnyqt3 343 12 . . . cord-325712-9kbnyqt3 344 1 If if IN cord-325712-9kbnyqt3 344 2 virions virion NNS cord-325712-9kbnyqt3 344 3 are be VBP cord-325712-9kbnyqt3 344 4 able able JJ cord-325712-9kbnyqt3 344 5 to to TO cord-325712-9kbnyqt3 344 6 release release VB cord-325712-9kbnyqt3 344 7 their -PRON- PRP$ cord-325712-9kbnyqt3 344 8 cargo cargo NN cord-325712-9kbnyqt3 344 9 during during IN cord-325712-9kbnyqt3 344 10 infection infection NN cord-325712-9kbnyqt3 344 11 , , , cord-325712-9kbnyqt3 344 12 BlaM BlaM NNP cord-325712-9kbnyqt3 344 13 will will MD cord-325712-9kbnyqt3 344 14 cleave cleave VB cord-325712-9kbnyqt3 344 15 the the DT cord-325712-9kbnyqt3 344 16 lactam lactam NNS cord-325712-9kbnyqt3 344 17 ring ring NN cord-325712-9kbnyqt3 344 18 , , , cord-325712-9kbnyqt3 344 19 interrupting interrupt VBG cord-325712-9kbnyqt3 344 20 FRET fret NN cord-325712-9kbnyqt3 344 21 and and CC cord-325712-9kbnyqt3 344 22 causing cause VBG cord-325712-9kbnyqt3 344 23 the the DT cord-325712-9kbnyqt3 344 24 cells cell NNS cord-325712-9kbnyqt3 344 25 to to TO cord-325712-9kbnyqt3 344 26 fluoresce fluoresce VB cord-325712-9kbnyqt3 344 27 a a DT cord-325712-9kbnyqt3 344 28 different different JJ cord-325712-9kbnyqt3 344 29 color color NN cord-325712-9kbnyqt3 344 30 [ [ -LRB- cord-325712-9kbnyqt3 344 31 155 155 CD cord-325712-9kbnyqt3 344 32 ] ] -RRB- cord-325712-9kbnyqt3 344 33 . . . cord-325712-9kbnyqt3 345 1 Infected infected JJ cord-325712-9kbnyqt3 345 2 and and CC cord-325712-9kbnyqt3 345 3 uninfected uninfected JJ cord-325712-9kbnyqt3 345 4 cells cell NNS cord-325712-9kbnyqt3 345 5 can can MD cord-325712-9kbnyqt3 345 6 then then RB cord-325712-9kbnyqt3 345 7 be be VB cord-325712-9kbnyqt3 345 8 sorted sort VBN cord-325712-9kbnyqt3 345 9 by by IN cord-325712-9kbnyqt3 345 10 flow flow NN cord-325712-9kbnyqt3 345 11 cytometry cytometry NN cord-325712-9kbnyqt3 345 12 for for IN cord-325712-9kbnyqt3 345 13 further further JJ cord-325712-9kbnyqt3 345 14 analysis analysis NN cord-325712-9kbnyqt3 345 15 . . . cord-325712-9kbnyqt3 346 1 This this DT cord-325712-9kbnyqt3 346 2 technique technique NN cord-325712-9kbnyqt3 346 3 requires require VBZ cord-325712-9kbnyqt3 346 4 the the DT cord-325712-9kbnyqt3 346 5 ability ability NN cord-325712-9kbnyqt3 346 6 to to TO cord-325712-9kbnyqt3 346 7 make make VB cord-325712-9kbnyqt3 346 8 chimeric chimeric JJ cord-325712-9kbnyqt3 346 9 proteins protein NNS cord-325712-9kbnyqt3 346 10 but but CC cord-325712-9kbnyqt3 346 11 otherwise otherwise RB cord-325712-9kbnyqt3 346 12 does do VBZ cord-325712-9kbnyqt3 346 13 not not RB cord-325712-9kbnyqt3 346 14 require require VB cord-325712-9kbnyqt3 346 15 specialized specialized JJ cord-325712-9kbnyqt3 346 16 equipment equipment NN cord-325712-9kbnyqt3 346 17 . . . cord-325712-9kbnyqt3 347 1 BlaM BlaM NNP cord-325712-9kbnyqt3 347 2 activity activity NN cord-325712-9kbnyqt3 347 3 assays assay NNS cord-325712-9kbnyqt3 347 4 have have VBP cord-325712-9kbnyqt3 347 5 been be VBN cord-325712-9kbnyqt3 347 6 combined combine VBN cord-325712-9kbnyqt3 347 7 with with IN cord-325712-9kbnyqt3 347 8 single single JJ cord-325712-9kbnyqt3 347 9 virion virion NN cord-325712-9kbnyqt3 347 10 imaging imaging NN cord-325712-9kbnyqt3 347 11 to to TO cord-325712-9kbnyqt3 347 12 indicate indicate VB cord-325712-9kbnyqt3 347 13 that that IN cord-325712-9kbnyqt3 347 14 HIV HIV NNP cord-325712-9kbnyqt3 347 15 releases release VBZ cord-325712-9kbnyqt3 347 16 cargo cargo NN cord-325712-9kbnyqt3 347 17 by by IN cord-325712-9kbnyqt3 347 18 fusion fusion NN cord-325712-9kbnyqt3 347 19 inside inside RB cord-325712-9kbnyqt3 347 20 endosomes endosome NNS cord-325712-9kbnyqt3 347 21 and and CC cord-325712-9kbnyqt3 347 22 not not RB cord-325712-9kbnyqt3 347 23 fusion fusion VB cord-325712-9kbnyqt3 347 24 at at IN cord-325712-9kbnyqt3 347 25 the the DT cord-325712-9kbnyqt3 347 26 plasma plasma NN cord-325712-9kbnyqt3 347 27 membrane membrane NN cord-325712-9kbnyqt3 347 28 surface surface NN cord-325712-9kbnyqt3 347 29 [ [ -LRB- cord-325712-9kbnyqt3 347 30 156 156 CD cord-325712-9kbnyqt3 347 31 ] ] -RRB- cord-325712-9kbnyqt3 347 32 . . . cord-325712-9kbnyqt3 348 1 Bulk bulk JJ cord-325712-9kbnyqt3 348 2 fusion fusion NN cord-325712-9kbnyqt3 348 3 provides provide VBZ cord-325712-9kbnyqt3 348 4 information information NN cord-325712-9kbnyqt3 348 5 on on IN cord-325712-9kbnyqt3 348 6 the the DT cord-325712-9kbnyqt3 348 7 kinetics kinetic NNS cord-325712-9kbnyqt3 348 8 of of IN cord-325712-9kbnyqt3 348 9 the the DT cord-325712-9kbnyqt3 348 10 fusion fusion NN cord-325712-9kbnyqt3 348 11 of of IN cord-325712-9kbnyqt3 348 12 the the DT cord-325712-9kbnyqt3 348 13 overall overall JJ cord-325712-9kbnyqt3 348 14 population population NN cord-325712-9kbnyqt3 348 15 in in IN cord-325712-9kbnyqt3 348 16 the the DT cord-325712-9kbnyqt3 348 17 solution solution NN cord-325712-9kbnyqt3 348 18 , , , cord-325712-9kbnyqt3 348 19 including include VBG cord-325712-9kbnyqt3 348 20 the the DT cord-325712-9kbnyqt3 348 21 lag lag JJ cord-325712-9kbnyqt3 348 22 time time NN cord-325712-9kbnyqt3 348 23 between between IN cord-325712-9kbnyqt3 348 24 when when WRB cord-325712-9kbnyqt3 348 25 the the DT cord-325712-9kbnyqt3 348 26 viruses virus NNS cord-325712-9kbnyqt3 348 27 are be VBP cord-325712-9kbnyqt3 348 28 exposed expose VBN cord-325712-9kbnyqt3 348 29 to to IN cord-325712-9kbnyqt3 348 30 a a DT cord-325712-9kbnyqt3 348 31 fusion fusion NN cord-325712-9kbnyqt3 348 32 trigger trigger NN cord-325712-9kbnyqt3 348 33 and and CC cord-325712-9kbnyqt3 348 34 when when WRB cord-325712-9kbnyqt3 348 35 dequenching dequenching NN cord-325712-9kbnyqt3 348 36 begins begin VBZ cord-325712-9kbnyqt3 348 37 , , , cord-325712-9kbnyqt3 348 38 with with IN cord-325712-9kbnyqt3 348 39 a a DT cord-325712-9kbnyqt3 348 40 resolution resolution NN cord-325712-9kbnyqt3 348 41 of of IN cord-325712-9kbnyqt3 348 42 less less JJR cord-325712-9kbnyqt3 348 43 than than IN cord-325712-9kbnyqt3 348 44 a a DT cord-325712-9kbnyqt3 348 45 second second JJ cord-325712-9kbnyqt3 348 46 [ [ -LRB- cord-325712-9kbnyqt3 348 47 157 157 CD cord-325712-9kbnyqt3 348 48 ] ] -RRB- cord-325712-9kbnyqt3 348 49 . . . cord-325712-9kbnyqt3 349 1 Varying vary VBG cord-325712-9kbnyqt3 349 2 the the DT cord-325712-9kbnyqt3 349 3 composition composition NN cord-325712-9kbnyqt3 349 4 of of IN cord-325712-9kbnyqt3 349 5 the the DT cord-325712-9kbnyqt3 349 6 liposomes liposome NNS cord-325712-9kbnyqt3 349 7 can can MD cord-325712-9kbnyqt3 349 8 reveal reveal VB cord-325712-9kbnyqt3 349 9 how how WRB cord-325712-9kbnyqt3 349 10 lipids lipid NNS cord-325712-9kbnyqt3 349 11 impact impact NN cord-325712-9kbnyqt3 349 12 viral viral JJ cord-325712-9kbnyqt3 349 13 fusion fusion NN cord-325712-9kbnyqt3 349 14 [ [ -LRB- cord-325712-9kbnyqt3 349 15 158 158 CD cord-325712-9kbnyqt3 349 16 ] ] -RRB- cord-325712-9kbnyqt3 349 17 . . . cord-325712-9kbnyqt3 350 1 However however RB cord-325712-9kbnyqt3 350 2 , , , cord-325712-9kbnyqt3 350 3 liposomes liposome NNS cord-325712-9kbnyqt3 350 4 containing contain VBG cord-325712-9kbnyqt3 350 5 the the DT cord-325712-9kbnyqt3 350 6 viral viral JJ cord-325712-9kbnyqt3 350 7 receptor receptor NN cord-325712-9kbnyqt3 350 8 may may MD cord-325712-9kbnyqt3 350 9 be be VB cord-325712-9kbnyqt3 350 10 hard hard JJ cord-325712-9kbnyqt3 350 11 to to TO cord-325712-9kbnyqt3 350 12 prepare prepare VB cord-325712-9kbnyqt3 350 13 if if IN cord-325712-9kbnyqt3 350 14 the the DT cord-325712-9kbnyqt3 350 15 receptor receptor NN cord-325712-9kbnyqt3 350 16 is be VBZ cord-325712-9kbnyqt3 350 17 a a DT cord-325712-9kbnyqt3 350 18 transmembrane transmembrane NN cord-325712-9kbnyqt3 350 19 protein protein NN cord-325712-9kbnyqt3 350 20 . . . cord-325712-9kbnyqt3 351 1 These these DT cord-325712-9kbnyqt3 351 2 assays assay NNS cord-325712-9kbnyqt3 351 3 can can MD cord-325712-9kbnyqt3 351 4 not not RB cord-325712-9kbnyqt3 351 5 resolve resolve VB cord-325712-9kbnyqt3 351 6 intermediate intermediate JJ cord-325712-9kbnyqt3 351 7 steps step NNS cord-325712-9kbnyqt3 351 8 like like IN cord-325712-9kbnyqt3 351 9 hemifusion hemifusion NN cord-325712-9kbnyqt3 351 10 , , , cord-325712-9kbnyqt3 351 11 or or CC cord-325712-9kbnyqt3 351 12 resolve resolve VB cord-325712-9kbnyqt3 351 13 fusion fusion NN cord-325712-9kbnyqt3 351 14 of of IN cord-325712-9kbnyqt3 351 15 individual individual JJ cord-325712-9kbnyqt3 351 16 virions virion NNS cord-325712-9kbnyqt3 351 17 , , , cord-325712-9kbnyqt3 351 18 but but CC cord-325712-9kbnyqt3 351 19 can can MD cord-325712-9kbnyqt3 351 20 be be VB cord-325712-9kbnyqt3 351 21 used use VBN cord-325712-9kbnyqt3 351 22 to to TO cord-325712-9kbnyqt3 351 23 determine determine VB cord-325712-9kbnyqt3 351 24 conditions condition NNS cord-325712-9kbnyqt3 351 25 interesting interesting JJ cord-325712-9kbnyqt3 351 26 for for IN cord-325712-9kbnyqt3 351 27 further further JJ cord-325712-9kbnyqt3 351 28 investigation investigation NN cord-325712-9kbnyqt3 351 29 with with IN cord-325712-9kbnyqt3 351 30 single single JJ cord-325712-9kbnyqt3 351 31 virion virion NN cord-325712-9kbnyqt3 351 32 tracking tracking NN cord-325712-9kbnyqt3 351 33 with with IN cord-325712-9kbnyqt3 351 34 SLBs slb NNS cord-325712-9kbnyqt3 351 35 [ [ -LRB- cord-325712-9kbnyqt3 351 36 137 137 CD cord-325712-9kbnyqt3 351 37 ] ] -RRB- cord-325712-9kbnyqt3 351 38 . . . cord-325712-9kbnyqt3 352 1 It -PRON- PRP cord-325712-9kbnyqt3 352 2 is be VBZ cord-325712-9kbnyqt3 352 3 worth worth JJ cord-325712-9kbnyqt3 352 4 noting note VBG cord-325712-9kbnyqt3 352 5 that that IN cord-325712-9kbnyqt3 352 6 single single JJ cord-325712-9kbnyqt3 352 7 virion virion NN cord-325712-9kbnyqt3 352 8 fusion fusion NN cord-325712-9kbnyqt3 352 9 tracking tracking NN cord-325712-9kbnyqt3 352 10 experiments experiment NNS cord-325712-9kbnyqt3 352 11 agree agree VBP cord-325712-9kbnyqt3 352 12 with with IN cord-325712-9kbnyqt3 352 13 data datum NNS cord-325712-9kbnyqt3 352 14 obtained obtain VBN cord-325712-9kbnyqt3 352 15 from from IN cord-325712-9kbnyqt3 352 16 bulk bulk JJ cord-325712-9kbnyqt3 352 17 fusion fusion NN cord-325712-9kbnyqt3 352 18 experiments experiment NNS cord-325712-9kbnyqt3 352 19 . . . cord-325712-9kbnyqt3 353 1 In in IN cord-325712-9kbnyqt3 353 2 a a DT cord-325712-9kbnyqt3 353 3 study study NN cord-325712-9kbnyqt3 353 4 directly directly RB cord-325712-9kbnyqt3 353 5 comparing compare VBG cord-325712-9kbnyqt3 353 6 the the DT cord-325712-9kbnyqt3 353 7 two two CD cord-325712-9kbnyqt3 353 8 methods method NNS cord-325712-9kbnyqt3 353 9 a a DT cord-325712-9kbnyqt3 353 10 combination combination NN cord-325712-9kbnyqt3 353 11 of of IN cord-325712-9kbnyqt3 353 12 bulk bulk JJ cord-325712-9kbnyqt3 353 13 fusion fusion NN cord-325712-9kbnyqt3 353 14 and and CC cord-325712-9kbnyqt3 353 15 single single JJ cord-325712-9kbnyqt3 353 16 virion virion NN cord-325712-9kbnyqt3 353 17 tracking tracking NN cord-325712-9kbnyqt3 353 18 showed show VBD cord-325712-9kbnyqt3 353 19 that that IN cord-325712-9kbnyqt3 353 20 cholesterol cholesterol NN cord-325712-9kbnyqt3 353 21 enhances enhance VBZ cord-325712-9kbnyqt3 353 22 the the DT cord-325712-9kbnyqt3 353 23 extent extent NN cord-325712-9kbnyqt3 353 24 of of IN cord-325712-9kbnyqt3 353 25 Sindbis Sindbis NNP cord-325712-9kbnyqt3 353 26 virus virus NN cord-325712-9kbnyqt3 353 27 fusion fusion NN cord-325712-9kbnyqt3 353 28 , , , cord-325712-9kbnyqt3 353 29 but but CC cord-325712-9kbnyqt3 353 30 increases increase VBZ cord-325712-9kbnyqt3 353 31 the the DT cord-325712-9kbnyqt3 353 32 lag lag NN cord-325712-9kbnyqt3 353 33 between between IN cord-325712-9kbnyqt3 353 34 binding binding NN cord-325712-9kbnyqt3 353 35 and and CC cord-325712-9kbnyqt3 353 36 fusion fusion NN cord-325712-9kbnyqt3 353 37 at at IN cord-325712-9kbnyqt3 353 38 pH pH NNP cord-325712-9kbnyqt3 353 39 less less JJR cord-325712-9kbnyqt3 353 40 than than IN cord-325712-9kbnyqt3 353 41 5 5 CD cord-325712-9kbnyqt3 353 42 , , , cord-325712-9kbnyqt3 353 43 revealing reveal VBG cord-325712-9kbnyqt3 353 44 a a DT cord-325712-9kbnyqt3 353 45 complicated complicated JJ cord-325712-9kbnyqt3 353 46 relationship relationship NN cord-325712-9kbnyqt3 353 47 between between IN cord-325712-9kbnyqt3 353 48 lipids lipid NNS cord-325712-9kbnyqt3 353 49 and and CC cord-325712-9kbnyqt3 353 50 viral viral JJ cord-325712-9kbnyqt3 353 51 fusion fusion NN cord-325712-9kbnyqt3 353 52 proteins protein NNS cord-325712-9kbnyqt3 353 53 in in IN cord-325712-9kbnyqt3 353 54 binding binding NN cord-325712-9kbnyqt3 353 55 and and CC cord-325712-9kbnyqt3 353 56 fusion fusion NN cord-325712-9kbnyqt3 353 57 [ [ -LRB- cord-325712-9kbnyqt3 353 58 34 34 CD cord-325712-9kbnyqt3 353 59 ] ] -RRB- cord-325712-9kbnyqt3 353 60 . . . cord-325712-9kbnyqt3 354 1 Methods method NNS cord-325712-9kbnyqt3 354 2 for for IN cord-325712-9kbnyqt3 354 3 studying study VBG cord-325712-9kbnyqt3 354 4 viral viral JJ cord-325712-9kbnyqt3 354 5 entry entry NN cord-325712-9kbnyqt3 354 6 vary vary VBP cord-325712-9kbnyqt3 354 7 widely widely RB cord-325712-9kbnyqt3 354 8 in in IN cord-325712-9kbnyqt3 354 9 functional functional JJ cord-325712-9kbnyqt3 354 10 characterization characterization NN cord-325712-9kbnyqt3 354 11 , , , cord-325712-9kbnyqt3 354 12 and and CC cord-325712-9kbnyqt3 354 13 structural structural JJ cord-325712-9kbnyqt3 354 14 and and CC cord-325712-9kbnyqt3 354 15 temporal temporal JJ cord-325712-9kbnyqt3 354 16 resolution resolution NN cord-325712-9kbnyqt3 354 17 . . . cord-325712-9kbnyqt3 355 1 No no DT cord-325712-9kbnyqt3 355 2 single single JJ cord-325712-9kbnyqt3 355 3 technique technique NN cord-325712-9kbnyqt3 355 4 is be VBZ cord-325712-9kbnyqt3 355 5 sufficient sufficient JJ cord-325712-9kbnyqt3 355 6 to to TO cord-325712-9kbnyqt3 355 7 determine determine VB cord-325712-9kbnyqt3 355 8 all all PDT cord-325712-9kbnyqt3 355 9 the the DT cord-325712-9kbnyqt3 355 10 steps step NNS cord-325712-9kbnyqt3 355 11 or or CC cord-325712-9kbnyqt3 355 12 details detail NNS cord-325712-9kbnyqt3 355 13 of of IN cord-325712-9kbnyqt3 355 14 viral viral JJ cord-325712-9kbnyqt3 355 15 entry entry NN cord-325712-9kbnyqt3 355 16 . . . cord-325712-9kbnyqt3 356 1 Single single JJ cord-325712-9kbnyqt3 356 2 virion virion NN cord-325712-9kbnyqt3 356 3 tracking tracking NN cord-325712-9kbnyqt3 356 4 techniques technique NNS cord-325712-9kbnyqt3 356 5 can can MD cord-325712-9kbnyqt3 356 6 bridge bridge VB cord-325712-9kbnyqt3 356 7 the the DT cord-325712-9kbnyqt3 356 8 gap gap NN cord-325712-9kbnyqt3 356 9 between between IN cord-325712-9kbnyqt3 356 10 detailed detailed JJ cord-325712-9kbnyqt3 356 11 structural structural JJ cord-325712-9kbnyqt3 356 12 information information NN cord-325712-9kbnyqt3 356 13 and and CC cord-325712-9kbnyqt3 356 14 overall overall JJ cord-325712-9kbnyqt3 356 15 infection infection NN cord-325712-9kbnyqt3 356 16 measurements measurement NNS cord-325712-9kbnyqt3 356 17 to to TO cord-325712-9kbnyqt3 356 18 inform inform VB cord-325712-9kbnyqt3 356 19 our -PRON- PRP$ cord-325712-9kbnyqt3 356 20 understanding understanding NN cord-325712-9kbnyqt3 356 21 of of IN cord-325712-9kbnyqt3 356 22 the the DT cord-325712-9kbnyqt3 356 23 structure structure NN cord-325712-9kbnyqt3 356 24 - - HYPH cord-325712-9kbnyqt3 356 25 function function NN cord-325712-9kbnyqt3 356 26 relationship relationship NN cord-325712-9kbnyqt3 356 27 of of IN cord-325712-9kbnyqt3 356 28 viral viral JJ cord-325712-9kbnyqt3 356 29 fusion fusion NN cord-325712-9kbnyqt3 356 30 proteins protein NNS cord-325712-9kbnyqt3 356 31 . . . cord-325712-9kbnyqt3 357 1 The the DT cord-325712-9kbnyqt3 357 2 development development NN cord-325712-9kbnyqt3 357 3 of of IN cord-325712-9kbnyqt3 357 4 single single JJ cord-325712-9kbnyqt3 357 5 virion virion NN cord-325712-9kbnyqt3 357 6 tracking tracking NN cord-325712-9kbnyqt3 357 7 techniques technique NNS cord-325712-9kbnyqt3 357 8 has have VBZ cord-325712-9kbnyqt3 357 9 been be VBN cord-325712-9kbnyqt3 357 10 dependent dependent JJ cord-325712-9kbnyqt3 357 11 on on IN cord-325712-9kbnyqt3 357 12 advances advance NNS cord-325712-9kbnyqt3 357 13 in in IN cord-325712-9kbnyqt3 357 14 viral viral JJ cord-325712-9kbnyqt3 357 15 labeling labeling NN cord-325712-9kbnyqt3 357 16 , , , cord-325712-9kbnyqt3 357 17 microscopy microscopy NNS cord-325712-9kbnyqt3 357 18 , , , cord-325712-9kbnyqt3 357 19 and and CC cord-325712-9kbnyqt3 357 20 image image NN cord-325712-9kbnyqt3 357 21 analysis analysis NN cord-325712-9kbnyqt3 357 22 . . . cord-325712-9kbnyqt3 358 1 These these DT cord-325712-9kbnyqt3 358 2 single single JJ cord-325712-9kbnyqt3 358 3 virion virion NN cord-325712-9kbnyqt3 358 4 techniques technique NNS cord-325712-9kbnyqt3 358 5 can can MD cord-325712-9kbnyqt3 358 6 be be VB cord-325712-9kbnyqt3 358 7 applied apply VBN cord-325712-9kbnyqt3 358 8 to to TO cord-325712-9kbnyqt3 358 9 study study VB cord-325712-9kbnyqt3 358 10 the the DT cord-325712-9kbnyqt3 358 11 progression progression NN cord-325712-9kbnyqt3 358 12 of of IN cord-325712-9kbnyqt3 358 13 infection infection NN cord-325712-9kbnyqt3 358 14 in in IN cord-325712-9kbnyqt3 358 15 live live JJ cord-325712-9kbnyqt3 358 16 cells cell NNS cord-325712-9kbnyqt3 358 17 as as RB cord-325712-9kbnyqt3 358 18 well well RB cord-325712-9kbnyqt3 358 19 as as IN cord-325712-9kbnyqt3 358 20 used use VBN cord-325712-9kbnyqt3 358 21 in in IN cord-325712-9kbnyqt3 358 22 a a DT cord-325712-9kbnyqt3 358 23 tightly tightly RB cord-325712-9kbnyqt3 358 24 - - HYPH cord-325712-9kbnyqt3 358 25 controlled control VBN cord-325712-9kbnyqt3 358 26 biomimetic biomimetic JJ cord-325712-9kbnyqt3 358 27 platform platform NN cord-325712-9kbnyqt3 358 28 . . . cord-325712-9kbnyqt3 359 1 Top top JJ cord-325712-9kbnyqt3 359 2 - - HYPH cord-325712-9kbnyqt3 359 3 down down RP cord-325712-9kbnyqt3 359 4 cell cell NN cord-325712-9kbnyqt3 359 5 culture culture NN cord-325712-9kbnyqt3 359 6 approaches approach VBZ cord-325712-9kbnyqt3 359 7 where where WRB cord-325712-9kbnyqt3 359 8 inhibition inhibition NN cord-325712-9kbnyqt3 359 9 or or CC cord-325712-9kbnyqt3 359 10 knockout knockout NN cord-325712-9kbnyqt3 359 11 of of IN cord-325712-9kbnyqt3 359 12 cellular cellular JJ cord-325712-9kbnyqt3 359 13 components component NNS cord-325712-9kbnyqt3 359 14 reveals reveal VBZ cord-325712-9kbnyqt3 359 15 their -PRON- PRP$ cord-325712-9kbnyqt3 359 16 role role NN cord-325712-9kbnyqt3 359 17 in in IN cord-325712-9kbnyqt3 359 18 viral viral JJ cord-325712-9kbnyqt3 359 19 entry entry NN cord-325712-9kbnyqt3 359 20 complement complement NN cord-325712-9kbnyqt3 359 21 bottom bottom RB cord-325712-9kbnyqt3 359 22 - - HYPH cord-325712-9kbnyqt3 359 23 up up RP cord-325712-9kbnyqt3 359 24 biomimetic biomimetic JJ cord-325712-9kbnyqt3 359 25 methods method NNS cord-325712-9kbnyqt3 359 26 where where WRB cord-325712-9kbnyqt3 359 27 components component NNS cord-325712-9kbnyqt3 359 28 of of IN cord-325712-9kbnyqt3 359 29 interest interest NN cord-325712-9kbnyqt3 359 30 are be VBP cord-325712-9kbnyqt3 359 31 methodically methodically RB cord-325712-9kbnyqt3 359 32 added add VBN cord-325712-9kbnyqt3 359 33 to to IN cord-325712-9kbnyqt3 359 34 the the DT cord-325712-9kbnyqt3 359 35 experimental experimental JJ cord-325712-9kbnyqt3 359 36 platform platform NN cord-325712-9kbnyqt3 359 37 . . . cord-325712-9kbnyqt3 360 1 Combining combine VBG cord-325712-9kbnyqt3 360 2 information information NN cord-325712-9kbnyqt3 360 3 from from IN cord-325712-9kbnyqt3 360 4 these these DT cord-325712-9kbnyqt3 360 5 different different JJ cord-325712-9kbnyqt3 360 6 techniques technique NNS cord-325712-9kbnyqt3 360 7 illuminates illuminate VBZ cord-325712-9kbnyqt3 360 8 the the DT cord-325712-9kbnyqt3 360 9 framework framework NN cord-325712-9kbnyqt3 360 10 of of IN cord-325712-9kbnyqt3 360 11 steps step NNS cord-325712-9kbnyqt3 360 12 involved involve VBN cord-325712-9kbnyqt3 360 13 in in IN cord-325712-9kbnyqt3 360 14 viral viral JJ cord-325712-9kbnyqt3 360 15 entry entry NN cord-325712-9kbnyqt3 360 16 and and CC cord-325712-9kbnyqt3 360 17 clarifies clarify VBZ cord-325712-9kbnyqt3 360 18 the the DT cord-325712-9kbnyqt3 360 19 mechanisms mechanism NNS cord-325712-9kbnyqt3 360 20 underlying underlie VBG cord-325712-9kbnyqt3 360 21 each each DT cord-325712-9kbnyqt3 360 22 step step NN cord-325712-9kbnyqt3 360 23 . . . cord-325712-9kbnyqt3 361 1 Virus virus NN cord-325712-9kbnyqt3 361 2 entry entry NN cord-325712-9kbnyqt3 361 3 : : : cord-325712-9kbnyqt3 361 4 open open JJ cord-325712-9kbnyqt3 361 5 sesame sesame NN cord-325712-9kbnyqt3 361 6 Principles Principles NNPS cord-325712-9kbnyqt3 361 7 of of IN cord-325712-9kbnyqt3 361 8 virology virology NN cord-325712-9kbnyqt3 361 9 , , , cord-325712-9kbnyqt3 361 10 volume volume NN cord-325712-9kbnyqt3 361 11 I -PRON- PRP cord-325712-9kbnyqt3 361 12 : : : cord-325712-9kbnyqt3 361 13 molecular molecular JJ cord-325712-9kbnyqt3 361 14 biology biology NN cord-325712-9kbnyqt3 361 15 Uncoating Uncoating NNP cord-325712-9kbnyqt3 361 16 of of IN cord-325712-9kbnyqt3 361 17 non non JJ cord-325712-9kbnyqt3 361 18 - - JJ cord-325712-9kbnyqt3 361 19 enveloped enveloped JJ cord-325712-9kbnyqt3 361 20 viruses virus NNS cord-325712-9kbnyqt3 361 21 Fusion Fusion NNP cord-325712-9kbnyqt3 361 22 of of IN cord-325712-9kbnyqt3 361 23 enveloped envelop VBN cord-325712-9kbnyqt3 361 24 viruses virus NNS cord-325712-9kbnyqt3 361 25 in in IN cord-325712-9kbnyqt3 361 26 endosomes endosomes JJ cord-325712-9kbnyqt3 361 27 Structures structure NNS cord-325712-9kbnyqt3 361 28 and and CC cord-325712-9kbnyqt3 361 29 mechanisms mechanism NNS cord-325712-9kbnyqt3 361 30 of of IN cord-325712-9kbnyqt3 361 31 viral viral JJ cord-325712-9kbnyqt3 361 32 membrane membrane NN cord-325712-9kbnyqt3 361 33 fusion fusion NN cord-325712-9kbnyqt3 361 34 proteins protein NNS cord-325712-9kbnyqt3 361 35 : : : cord-325712-9kbnyqt3 361 36 multiple multiple JJ cord-325712-9kbnyqt3 361 37 variations variation NNS cord-325712-9kbnyqt3 361 38 on on IN cord-325712-9kbnyqt3 361 39 a a DT cord-325712-9kbnyqt3 361 40 common common JJ cord-325712-9kbnyqt3 361 41 theme theme NN cord-325712-9kbnyqt3 361 42 Protease protease NN cord-325712-9kbnyqt3 361 43 - - HYPH cord-325712-9kbnyqt3 361 44 mediated mediate VBN cord-325712-9kbnyqt3 361 45 enhancement enhancement NN cord-325712-9kbnyqt3 361 46 of of IN cord-325712-9kbnyqt3 361 47 severe severe JJ cord-325712-9kbnyqt3 361 48 acute acute JJ cord-325712-9kbnyqt3 361 49 respiratory respiratory JJ cord-325712-9kbnyqt3 361 50 syndrome syndrome NN cord-325712-9kbnyqt3 361 51 coronavirus coronavirus NN cord-325712-9kbnyqt3 361 52 infection infection NN cord-325712-9kbnyqt3 361 53 Principles principle NNS cord-325712-9kbnyqt3 361 54 of of IN cord-325712-9kbnyqt3 361 55 virus virus NN cord-325712-9kbnyqt3 361 56 uncoating uncoating NN cord-325712-9kbnyqt3 361 57 : : : cord-325712-9kbnyqt3 361 58 cues cue NNS cord-325712-9kbnyqt3 361 59 and and CC cord-325712-9kbnyqt3 361 60 the the DT cord-325712-9kbnyqt3 361 61 snooker snooker NNP cord-325712-9kbnyqt3 361 62 ball ball NN cord-325712-9kbnyqt3 361 63 Viral Viral NNP cord-325712-9kbnyqt3 361 64 membrane membrane NN cord-325712-9kbnyqt3 361 65 fusion fusion NN cord-325712-9kbnyqt3 361 66 Real real JJ cord-325712-9kbnyqt3 361 67 - - HYPH cord-325712-9kbnyqt3 361 68 time time NN cord-325712-9kbnyqt3 361 69 imaging imaging NN cord-325712-9kbnyqt3 361 70 of of IN cord-325712-9kbnyqt3 361 71 single single JJ cord-325712-9kbnyqt3 361 72 HIV-1 HIV-1 NNP cord-325712-9kbnyqt3 361 73 disassembly disassembly NN cord-325712-9kbnyqt3 361 74 with with IN cord-325712-9kbnyqt3 361 75 multicolor multicolor JJ cord-325712-9kbnyqt3 361 76 viral viral JJ cord-325712-9kbnyqt3 361 77 particles particle NNS cord-325712-9kbnyqt3 361 78 Visualizing visualize VBG cord-325712-9kbnyqt3 361 79 infection infection NN cord-325712-9kbnyqt3 361 80 of of IN cord-325712-9kbnyqt3 361 81 individual individual JJ cord-325712-9kbnyqt3 361 82 influenza influenza NN cord-325712-9kbnyqt3 361 83 viruses virus NNS cord-325712-9kbnyqt3 362 1 Direct direct JJ cord-325712-9kbnyqt3 362 2 visualization visualization NN cord-325712-9kbnyqt3 362 3 of of IN cord-325712-9kbnyqt3 362 4 Ebola Ebola NNP cord-325712-9kbnyqt3 362 5 virus virus NN cord-325712-9kbnyqt3 362 6 fusion fusion NN cord-325712-9kbnyqt3 362 7 triggering trigger VBG cord-325712-9kbnyqt3 362 8 in in IN cord-325712-9kbnyqt3 362 9 the the DT cord-325712-9kbnyqt3 362 10 endocytic endocytic JJ cord-325712-9kbnyqt3 362 11 pathway pathway NN cord-325712-9kbnyqt3 362 12 Influenza Influenza NNP cord-325712-9kbnyqt3 362 13 virus virus NN cord-325712-9kbnyqt3 362 14 - - HYPH cord-325712-9kbnyqt3 362 15 membrane membrane NN cord-325712-9kbnyqt3 362 16 fusion fusion NN cord-325712-9kbnyqt3 362 17 triggered trigger VBN cord-325712-9kbnyqt3 362 18 by by IN cord-325712-9kbnyqt3 362 19 proton proton NN cord-325712-9kbnyqt3 362 20 uncaging uncage VBG cord-325712-9kbnyqt3 362 21 for for IN cord-325712-9kbnyqt3 362 22 single single JJ cord-325712-9kbnyqt3 362 23 particle particle NN cord-325712-9kbnyqt3 362 24 studies study NNS cord-325712-9kbnyqt3 362 25 of of IN cord-325712-9kbnyqt3 362 26 fusion fusion NN cord-325712-9kbnyqt3 362 27 kinetics kinetics NNP cord-325712-9kbnyqt3 362 28 Single Single NNP cord-325712-9kbnyqt3 362 29 particle particle NN cord-325712-9kbnyqt3 362 30 assay assay NN cord-325712-9kbnyqt3 362 31 of of IN cord-325712-9kbnyqt3 362 32 coronavirus coronavirus NN cord-325712-9kbnyqt3 362 33 membrane membrane NN cord-325712-9kbnyqt3 362 34 fusion fusion NN cord-325712-9kbnyqt3 362 35 with with IN cord-325712-9kbnyqt3 362 36 proteinaceous proteinaceous JJ cord-325712-9kbnyqt3 362 37 receptor receptor NN cord-325712-9kbnyqt3 362 38 - - HYPH cord-325712-9kbnyqt3 362 39 embedded embed VBN cord-325712-9kbnyqt3 362 40 supported support VBD cord-325712-9kbnyqt3 362 41 bilayers bilayer NNS cord-325712-9kbnyqt3 362 42 Analysis Analysis NNP cord-325712-9kbnyqt3 362 43 of of IN cord-325712-9kbnyqt3 362 44 virus virus NN cord-325712-9kbnyqt3 362 45 entry entry NN cord-325712-9kbnyqt3 362 46 and and CC cord-325712-9kbnyqt3 362 47 cellular cellular JJ cord-325712-9kbnyqt3 362 48 membrane membrane NN cord-325712-9kbnyqt3 362 49 dynamics dynamic NNS cord-325712-9kbnyqt3 362 50 by by IN cord-325712-9kbnyqt3 362 51 single single JJ cord-325712-9kbnyqt3 362 52 particle particle NN cord-325712-9kbnyqt3 362 53 tracking tracking NN cord-325712-9kbnyqt3 362 54 Analysis Analysis NNP cord-325712-9kbnyqt3 362 55 of of IN cord-325712-9kbnyqt3 362 56 kinetic kinetic JJ cord-325712-9kbnyqt3 362 57 intermediates intermediate NNS cord-325712-9kbnyqt3 362 58 in in IN cord-325712-9kbnyqt3 362 59 singleparticle singleparticle NNP cord-325712-9kbnyqt3 362 60 dwell dwell VB cord-325712-9kbnyqt3 362 61 - - HYPH cord-325712-9kbnyqt3 362 62 time time NN cord-325712-9kbnyqt3 362 63 distributions distribution NNS cord-325712-9kbnyqt3 362 64 On on IN cord-325712-9kbnyqt3 362 65 the the DT cord-325712-9kbnyqt3 362 66 entry entry NN cord-325712-9kbnyqt3 362 67 of of IN cord-325712-9kbnyqt3 362 68 Semliki Semliki NNP cord-325712-9kbnyqt3 362 69 forest forest NN cord-325712-9kbnyqt3 362 70 virus virus NN cord-325712-9kbnyqt3 362 71 into into IN cord-325712-9kbnyqt3 362 72 BHK-21 BHK-21 NNP cord-325712-9kbnyqt3 362 73 cells cell VBZ cord-325712-9kbnyqt3 362 74 Real real JJ cord-325712-9kbnyqt3 362 75 - - HYPH cord-325712-9kbnyqt3 362 76 time time NN cord-325712-9kbnyqt3 362 77 single single JJ cord-325712-9kbnyqt3 362 78 - - HYPH cord-325712-9kbnyqt3 362 79 molecule molecule NN cord-325712-9kbnyqt3 362 80 imaging imaging NN cord-325712-9kbnyqt3 362 81 of of IN cord-325712-9kbnyqt3 362 82 the the DT cord-325712-9kbnyqt3 362 83 infection infection NN cord-325712-9kbnyqt3 362 84 pathway pathway NN cord-325712-9kbnyqt3 362 85 of of IN cord-325712-9kbnyqt3 362 86 an an DT cord-325712-9kbnyqt3 362 87 adeno adeno NN cord-325712-9kbnyqt3 362 88 - - HYPH cord-325712-9kbnyqt3 362 89 associated associate VBN cord-325712-9kbnyqt3 362 90 virus virus NN cord-325712-9kbnyqt3 362 91 Microtubule Microtubule NNP cord-325712-9kbnyqt3 362 92 - - HYPH cord-325712-9kbnyqt3 362 93 dependent dependent JJ cord-325712-9kbnyqt3 362 94 plus plus NN cord-325712-9kbnyqt3 362 95 - - HYPH cord-325712-9kbnyqt3 362 96 and and CC cord-325712-9kbnyqt3 362 97 minus minus CC cord-325712-9kbnyqt3 362 98 end end NN cord-325712-9kbnyqt3 362 99 - - HYPH cord-325712-9kbnyqt3 362 100 directed direct VBN cord-325712-9kbnyqt3 362 101 motilities motility NNS cord-325712-9kbnyqt3 362 102 are be VBP cord-325712-9kbnyqt3 362 103 competing compete VBG cord-325712-9kbnyqt3 362 104 processes process NNS cord-325712-9kbnyqt3 362 105 for for IN cord-325712-9kbnyqt3 362 106 nuclear nuclear JJ cord-325712-9kbnyqt3 362 107 targeting targeting NN cord-325712-9kbnyqt3 362 108 of of IN cord-325712-9kbnyqt3 362 109 adenovirus adenovirus NN cord-325712-9kbnyqt3 362 110 Detectors detector NNS cord-325712-9kbnyqt3 362 111 for for IN cord-325712-9kbnyqt3 362 112 single single JJ cord-325712-9kbnyqt3 362 113 - - HYPH cord-325712-9kbnyqt3 362 114 molecule molecule NN cord-325712-9kbnyqt3 362 115 fluorescence fluorescence NN cord-325712-9kbnyqt3 362 116 imaging imaging NN cord-325712-9kbnyqt3 362 117 and and CC cord-325712-9kbnyqt3 362 118 spectroscopy spectroscopy NN cord-325712-9kbnyqt3 362 119 Visualization visualization NN cord-325712-9kbnyqt3 362 120 of of IN cord-325712-9kbnyqt3 362 121 membrane membrane NN cord-325712-9kbnyqt3 362 122 fusion fusion NN cord-325712-9kbnyqt3 362 123 , , , cord-325712-9kbnyqt3 362 124 one one CD cord-325712-9kbnyqt3 362 125 particle particle NN cord-325712-9kbnyqt3 362 126 at at IN cord-325712-9kbnyqt3 362 127 a a DT cord-325712-9kbnyqt3 362 128 time time NN cord-325712-9kbnyqt3 362 129 Single single JJ cord-325712-9kbnyqt3 362 130 particle particle NN cord-325712-9kbnyqt3 362 131 tracking tracking NN cord-325712-9kbnyqt3 362 132 : : : cord-325712-9kbnyqt3 362 133 from from IN cord-325712-9kbnyqt3 362 134 theory theory NN cord-325712-9kbnyqt3 362 135 to to IN cord-325712-9kbnyqt3 362 136 biophysical biophysical JJ cord-325712-9kbnyqt3 362 137 applications application NNS cord-325712-9kbnyqt3 363 1 Virus virus NN cord-325712-9kbnyqt3 363 2 trafficking trafficking NN cord-325712-9kbnyqt3 363 3 - - HYPH cord-325712-9kbnyqt3 363 4 learning learn VBG cord-325712-9kbnyqt3 363 5 from from IN cord-325712-9kbnyqt3 363 6 single single JJ cord-325712-9kbnyqt3 363 7 - - HYPH cord-325712-9kbnyqt3 363 8 virus virus NN cord-325712-9kbnyqt3 363 9 tracking tracking NN cord-325712-9kbnyqt3 363 10 Imaging Imaging NNP cord-325712-9kbnyqt3 363 11 , , , cord-325712-9kbnyqt3 363 12 tracking tracking NN cord-325712-9kbnyqt3 363 13 and and CC cord-325712-9kbnyqt3 363 14 computational computational JJ cord-325712-9kbnyqt3 363 15 analyses analysis NNS cord-325712-9kbnyqt3 363 16 of of IN cord-325712-9kbnyqt3 363 17 virus virus NN cord-325712-9kbnyqt3 363 18 entry entry NN cord-325712-9kbnyqt3 363 19 and and CC cord-325712-9kbnyqt3 363 20 egress egress NN cord-325712-9kbnyqt3 363 21 with with IN cord-325712-9kbnyqt3 363 22 the the DT cord-325712-9kbnyqt3 363 23 cytoskeleton cytoskeleton NN cord-325712-9kbnyqt3 363 24 Total total JJ cord-325712-9kbnyqt3 363 25 internal internal JJ cord-325712-9kbnyqt3 363 26 reflection reflection NN cord-325712-9kbnyqt3 363 27 fluorescence fluorescence NN cord-325712-9kbnyqt3 363 28 microscopy microscopy NNS cord-325712-9kbnyqt3 363 29 in in IN cord-325712-9kbnyqt3 363 30 cell cell NN cord-325712-9kbnyqt3 363 31 biology biology NN cord-325712-9kbnyqt3 363 32 Imaging Imaging NNP cord-325712-9kbnyqt3 363 33 with with IN cord-325712-9kbnyqt3 363 34 total total JJ cord-325712-9kbnyqt3 363 35 internal internal JJ cord-325712-9kbnyqt3 363 36 reflection reflection NN cord-325712-9kbnyqt3 363 37 fluorescence fluorescence NN cord-325712-9kbnyqt3 363 38 microscopy microscopy NNS cord-325712-9kbnyqt3 363 39 for for IN cord-325712-9kbnyqt3 363 40 the the DT cord-325712-9kbnyqt3 363 41 cell cell NN cord-325712-9kbnyqt3 363 42 biologist biologist NN cord-325712-9kbnyqt3 363 43 Phototoxicity Phototoxicity NNP cord-325712-9kbnyqt3 363 44 in in IN cord-325712-9kbnyqt3 363 45 live live JJ cord-325712-9kbnyqt3 363 46 fluorescence fluorescence NN cord-325712-9kbnyqt3 363 47 microscopy microscopy NN cord-325712-9kbnyqt3 363 48 , , , cord-325712-9kbnyqt3 363 49 and and CC cord-325712-9kbnyqt3 363 50 how how WRB cord-325712-9kbnyqt3 363 51 to to TO cord-325712-9kbnyqt3 363 52 avoid avoid VB cord-325712-9kbnyqt3 363 53 it -PRON- PRP cord-325712-9kbnyqt3 363 54 Progress Progress NNP cord-325712-9kbnyqt3 363 55 on on IN cord-325712-9kbnyqt3 363 56 the the DT cord-325712-9kbnyqt3 363 57 labeling labeling NN cord-325712-9kbnyqt3 363 58 and and CC cord-325712-9kbnyqt3 363 59 single single JJ cord-325712-9kbnyqt3 363 60 - - HYPH cord-325712-9kbnyqt3 363 61 particle particle NN cord-325712-9kbnyqt3 363 62 tracking tracking NN cord-325712-9kbnyqt3 363 63 technologies technology NNS cord-325712-9kbnyqt3 363 64 of of IN cord-325712-9kbnyqt3 363 65 viruses virus NNS cord-325712-9kbnyqt3 363 66 Tracking track VBG cord-325712-9kbnyqt3 363 67 single single JJ cord-325712-9kbnyqt3 363 68 viruses virus NNS cord-325712-9kbnyqt3 363 69 infecting infect VBG cord-325712-9kbnyqt3 363 70 their -PRON- PRP$ cord-325712-9kbnyqt3 363 71 host host NN cord-325712-9kbnyqt3 363 72 cells cell NNS cord-325712-9kbnyqt3 363 73 using use VBG cord-325712-9kbnyqt3 363 74 quantum quantum NN cord-325712-9kbnyqt3 363 75 dots dot NNS cord-325712-9kbnyqt3 363 76 Live live JJ cord-325712-9kbnyqt3 363 77 cell cell NN cord-325712-9kbnyqt3 363 78 imaging imaging NN cord-325712-9kbnyqt3 363 79 of of IN cord-325712-9kbnyqt3 363 80 viral viral JJ cord-325712-9kbnyqt3 363 81 entry entry NN cord-325712-9kbnyqt3 363 82 Visualization visualization NN cord-325712-9kbnyqt3 363 83 of of IN cord-325712-9kbnyqt3 363 84 the the DT cord-325712-9kbnyqt3 363 85 intracellular intracellular JJ cord-325712-9kbnyqt3 363 86 behavior behavior NN cord-325712-9kbnyqt3 363 87 of of IN cord-325712-9kbnyqt3 363 88 HIV HIV NNP cord-325712-9kbnyqt3 363 89 in in IN cord-325712-9kbnyqt3 363 90 living living NN cord-325712-9kbnyqt3 363 91 cells cell NNS cord-325712-9kbnyqt3 363 92 Individual individual JJ cord-325712-9kbnyqt3 363 93 rotavirus rotavirus NN cord-325712-9kbnyqt3 363 94 - - HYPH cord-325712-9kbnyqt3 363 95 like like JJ cord-325712-9kbnyqt3 363 96 particles particle NNS cord-325712-9kbnyqt3 363 97 containing contain VBG cord-325712-9kbnyqt3 363 98 120 120 CD cord-325712-9kbnyqt3 363 99 molecules molecule NNS cord-325712-9kbnyqt3 363 100 of of IN cord-325712-9kbnyqt3 363 101 fluorescent fluorescent JJ cord-325712-9kbnyqt3 363 102 protein protein NN cord-325712-9kbnyqt3 363 103 are be VBP cord-325712-9kbnyqt3 363 104 visible visible JJ cord-325712-9kbnyqt3 363 105 in in IN cord-325712-9kbnyqt3 363 106 living live VBG cord-325712-9kbnyqt3 363 107 cells cell NNS cord-325712-9kbnyqt3 364 1 Incorporation incorporation NN cord-325712-9kbnyqt3 364 2 of of IN cord-325712-9kbnyqt3 364 3 the the DT cord-325712-9kbnyqt3 364 4 green green JJ cord-325712-9kbnyqt3 364 5 fluorescent fluorescent NN cord-325712-9kbnyqt3 364 6 protein protein NN cord-325712-9kbnyqt3 364 7 into into IN cord-325712-9kbnyqt3 364 8 the the DT cord-325712-9kbnyqt3 364 9 herpes herpes NNP cord-325712-9kbnyqt3 364 10 simplex simplex NNP cord-325712-9kbnyqt3 364 11 virus virus NN cord-325712-9kbnyqt3 364 12 type type NN cord-325712-9kbnyqt3 364 13 1 1 CD cord-325712-9kbnyqt3 364 14 capsid capsid NN cord-325712-9kbnyqt3 364 15 Single single JJ cord-325712-9kbnyqt3 364 16 - - HYPH cord-325712-9kbnyqt3 364 17 particle particle NN cord-325712-9kbnyqt3 364 18 kinetics kinetic NNS cord-325712-9kbnyqt3 364 19 of of IN cord-325712-9kbnyqt3 364 20 influenza influenza NN cord-325712-9kbnyqt3 364 21 virus virus NN cord-325712-9kbnyqt3 364 22 membrane membrane NN cord-325712-9kbnyqt3 364 23 fusion fusion NN cord-325712-9kbnyqt3 364 24 Rapid Rapid NNP cord-325712-9kbnyqt3 364 25 membrane membrane NN cord-325712-9kbnyqt3 364 26 fusion fusion NN cord-325712-9kbnyqt3 364 27 of of IN cord-325712-9kbnyqt3 364 28 individual individual JJ cord-325712-9kbnyqt3 364 29 virus virus NN cord-325712-9kbnyqt3 364 30 particles particle NNS cord-325712-9kbnyqt3 364 31 with with IN cord-325712-9kbnyqt3 364 32 supported support VBN cord-325712-9kbnyqt3 364 33 lipid lipid NN cord-325712-9kbnyqt3 364 34 bilayers bilayer NNS cord-325712-9kbnyqt3 365 1 Quantitative quantitative JJ cord-325712-9kbnyqt3 365 2 imaging imaging NN cord-325712-9kbnyqt3 365 3 of of IN cord-325712-9kbnyqt3 365 4 endosome endosome NN cord-325712-9kbnyqt3 365 5 acidification acidification NN cord-325712-9kbnyqt3 365 6 and and CC cord-325712-9kbnyqt3 365 7 single single JJ cord-325712-9kbnyqt3 365 8 retrovirus retrovirus NN cord-325712-9kbnyqt3 365 9 fusion fusion NN cord-325712-9kbnyqt3 365 10 with with IN cord-325712-9kbnyqt3 365 11 distinct distinct JJ cord-325712-9kbnyqt3 365 12 pools pool NNS cord-325712-9kbnyqt3 365 13 of of IN cord-325712-9kbnyqt3 365 14 early early JJ cord-325712-9kbnyqt3 365 15 endosomes endosome NNS cord-325712-9kbnyqt3 365 16 High high JJ cord-325712-9kbnyqt3 365 17 - - HYPH cord-325712-9kbnyqt3 365 18 speed speed NN cord-325712-9kbnyqt3 365 19 nanoscopic nanoscopic JJ cord-325712-9kbnyqt3 365 20 tracking tracking NN cord-325712-9kbnyqt3 365 21 of of IN cord-325712-9kbnyqt3 365 22 the the DT cord-325712-9kbnyqt3 365 23 position position NN cord-325712-9kbnyqt3 365 24 and and CC cord-325712-9kbnyqt3 365 25 orientation orientation NN cord-325712-9kbnyqt3 365 26 of of IN cord-325712-9kbnyqt3 365 27 a a DT cord-325712-9kbnyqt3 365 28 single single JJ cord-325712-9kbnyqt3 365 29 virus virus NN cord-325712-9kbnyqt3 365 30 Image image NN cord-325712-9kbnyqt3 365 31 restoration restoration NN cord-325712-9kbnyqt3 365 32 and and CC cord-325712-9kbnyqt3 365 33 analysis analysis NN cord-325712-9kbnyqt3 365 34 of of IN cord-325712-9kbnyqt3 365 35 influenza influenza NN cord-325712-9kbnyqt3 365 36 virions virion NNS cord-325712-9kbnyqt3 365 37 binding bind VBG cord-325712-9kbnyqt3 365 38 to to IN cord-325712-9kbnyqt3 365 39 membrane membrane NN cord-325712-9kbnyqt3 365 40 receptors receptor NNS cord-325712-9kbnyqt3 365 41 reveal reveal VBP cord-325712-9kbnyqt3 365 42 adhesion adhesion NN cord-325712-9kbnyqt3 365 43 - - HYPH cord-325712-9kbnyqt3 365 44 strengthening strengthen VBG cord-325712-9kbnyqt3 365 45 kinetics kinetic NNS cord-325712-9kbnyqt3 366 1 Tracking track VBG cord-325712-9kbnyqt3 366 2 single single JJ cord-325712-9kbnyqt3 366 3 particles particle NNS cord-325712-9kbnyqt3 366 4 : : : cord-325712-9kbnyqt3 367 1 a a DT cord-325712-9kbnyqt3 367 2 user user NN cord-325712-9kbnyqt3 367 3 - - HYPH cord-325712-9kbnyqt3 367 4 friendly friendly JJ cord-325712-9kbnyqt3 367 5 quantitative quantitative JJ cord-325712-9kbnyqt3 367 6 evaluation evaluation NN cord-325712-9kbnyqt3 367 7 Tracking tracking NN cord-325712-9kbnyqt3 367 8 in in IN cord-325712-9kbnyqt3 367 9 cell cell NN cord-325712-9kbnyqt3 367 10 and and CC cord-325712-9kbnyqt3 367 11 developmental developmental JJ cord-325712-9kbnyqt3 367 12 biology biology NN cord-325712-9kbnyqt3 367 13 Feature feature NN cord-325712-9kbnyqt3 367 14 point point NN cord-325712-9kbnyqt3 367 15 tracking tracking NN cord-325712-9kbnyqt3 367 16 and and CC cord-325712-9kbnyqt3 367 17 trajectory trajectory NN cord-325712-9kbnyqt3 367 18 analysis analysis NN cord-325712-9kbnyqt3 367 19 for for IN cord-325712-9kbnyqt3 367 20 video video NN cord-325712-9kbnyqt3 367 21 imaging imaging NN cord-325712-9kbnyqt3 367 22 in in IN cord-325712-9kbnyqt3 367 23 cell cell NN cord-325712-9kbnyqt3 367 24 biology biology NN cord-325712-9kbnyqt3 367 25 Single single JJ cord-325712-9kbnyqt3 367 26 - - HYPH cord-325712-9kbnyqt3 367 27 particle particle NN cord-325712-9kbnyqt3 367 28 tracking tracking NN cord-325712-9kbnyqt3 367 29 as as IN cord-325712-9kbnyqt3 367 30 a a DT cord-325712-9kbnyqt3 367 31 quantitative quantitative JJ cord-325712-9kbnyqt3 367 32 microscopy microscopy NN cord-325712-9kbnyqt3 367 33 - - HYPH cord-325712-9kbnyqt3 367 34 based base VBN cord-325712-9kbnyqt3 367 35 approach approach NN cord-325712-9kbnyqt3 367 36 to to TO cord-325712-9kbnyqt3 367 37 unravel unravel VB cord-325712-9kbnyqt3 367 38 cell cell NN cord-325712-9kbnyqt3 367 39 entry entry NN cord-325712-9kbnyqt3 367 40 mechanisms mechanism NNS cord-325712-9kbnyqt3 367 41 of of IN cord-325712-9kbnyqt3 367 42 viruses virus NNS cord-325712-9kbnyqt3 367 43 and and CC cord-325712-9kbnyqt3 367 44 pharmaceutical pharmaceutical NN cord-325712-9kbnyqt3 367 45 nanoparticles nanoparticle NNS cord-325712-9kbnyqt3 367 46 Digital Digital NNP cord-325712-9kbnyqt3 367 47 fluorescence fluorescence NN cord-325712-9kbnyqt3 367 48 imaging imaging NN cord-325712-9kbnyqt3 367 49 of of IN cord-325712-9kbnyqt3 367 50 fusion fusion NN cord-325712-9kbnyqt3 367 51 of of IN cord-325712-9kbnyqt3 367 52 influenza influenza NN cord-325712-9kbnyqt3 367 53 virus virus NN cord-325712-9kbnyqt3 367 54 with with IN cord-325712-9kbnyqt3 367 55 erythrocytes erythrocyte NNS cord-325712-9kbnyqt3 367 56 Observation observation NN cord-325712-9kbnyqt3 367 57 of of IN cord-325712-9kbnyqt3 367 58 single single JJ cord-325712-9kbnyqt3 367 59 influenza influenza NN cord-325712-9kbnyqt3 367 60 virus virus NN cord-325712-9kbnyqt3 367 61 - - HYPH cord-325712-9kbnyqt3 367 62 cell cell NN cord-325712-9kbnyqt3 367 63 fusion fusion NN cord-325712-9kbnyqt3 367 64 and and CC cord-325712-9kbnyqt3 367 65 measurement measurement NN cord-325712-9kbnyqt3 367 66 by by IN cord-325712-9kbnyqt3 367 67 fluorescence fluorescence NN cord-325712-9kbnyqt3 367 68 video video NN cord-325712-9kbnyqt3 367 69 microscopy microscopy NN cord-325712-9kbnyqt3 367 70 Fusion fusion NN cord-325712-9kbnyqt3 367 71 of of IN cord-325712-9kbnyqt3 367 72 influenza influenza NN cord-325712-9kbnyqt3 367 73 virions virion NNS cord-325712-9kbnyqt3 367 74 with with IN cord-325712-9kbnyqt3 367 75 a a DT cord-325712-9kbnyqt3 367 76 planar planar JJ cord-325712-9kbnyqt3 367 77 lipid lipid NN cord-325712-9kbnyqt3 367 78 membrane membrane NN cord-325712-9kbnyqt3 367 79 detected detect VBN cord-325712-9kbnyqt3 367 80 by by IN cord-325712-9kbnyqt3 367 81 video video NN cord-325712-9kbnyqt3 367 82 fluorescence fluorescence NN cord-325712-9kbnyqt3 367 83 microscopy microscopy NN cord-325712-9kbnyqt3 368 1 The the DT cord-325712-9kbnyqt3 368 2 role role NN cord-325712-9kbnyqt3 368 3 of of IN cord-325712-9kbnyqt3 368 4 N n NN cord-325712-9kbnyqt3 368 5 - - HYPH cord-325712-9kbnyqt3 368 6 acetylneuraminic acetylneuraminic NNP cord-325712-9kbnyqt3 368 7 ( ( -LRB- cord-325712-9kbnyqt3 368 8 sialic sialic NN cord-325712-9kbnyqt3 368 9 ) ) -RRB- cord-325712-9kbnyqt3 368 10 acid acid NN cord-325712-9kbnyqt3 368 11 in in IN cord-325712-9kbnyqt3 368 12 the the DT cord-325712-9kbnyqt3 368 13 pH pH NNP cord-325712-9kbnyqt3 368 14 dependence dependence NN cord-325712-9kbnyqt3 368 15 of of IN cord-325712-9kbnyqt3 368 16 influenza influenza NN cord-325712-9kbnyqt3 368 17 virion virion NN cord-325712-9kbnyqt3 368 18 fusion fusion NN cord-325712-9kbnyqt3 368 19 with with IN cord-325712-9kbnyqt3 368 20 planar planar JJ cord-325712-9kbnyqt3 368 21 phospholipid phospholipid NN cord-325712-9kbnyqt3 368 22 membranes membrane NNS cord-325712-9kbnyqt3 368 23 Supported support VBD cord-325712-9kbnyqt3 368 24 membranes membrane NNS cord-325712-9kbnyqt3 368 25 : : : cord-325712-9kbnyqt3 368 26 scientific scientific JJ cord-325712-9kbnyqt3 368 27 and and CC cord-325712-9kbnyqt3 368 28 practical practical JJ cord-325712-9kbnyqt3 368 29 applications application NNS cord-325712-9kbnyqt3 368 30 Polymer polymer NN cord-325712-9kbnyqt3 368 31 - - HYPH cord-325712-9kbnyqt3 368 32 supported support VBN cord-325712-9kbnyqt3 368 33 membranes membrane NNS cord-325712-9kbnyqt3 368 34 as as IN cord-325712-9kbnyqt3 368 35 models model NNS cord-325712-9kbnyqt3 368 36 of of IN cord-325712-9kbnyqt3 368 37 the the DT cord-325712-9kbnyqt3 368 38 cell cell NN cord-325712-9kbnyqt3 368 39 surface surface NN cord-325712-9kbnyqt3 368 40 Solid Solid NNP cord-325712-9kbnyqt3 368 41 supported support VBD cord-325712-9kbnyqt3 368 42 lipid lipid NN cord-325712-9kbnyqt3 368 43 bilayers bilayer NNS cord-325712-9kbnyqt3 368 44 : : : cord-325712-9kbnyqt3 368 45 from from IN cord-325712-9kbnyqt3 368 46 biophysical biophysical JJ cord-325712-9kbnyqt3 368 47 studies study NNS cord-325712-9kbnyqt3 368 48 to to TO cord-325712-9kbnyqt3 368 49 sensor sensor VB cord-325712-9kbnyqt3 368 50 design design NN cord-325712-9kbnyqt3 368 51 Norovirus norovirus IN cord-325712-9kbnyqt3 368 52 GII.4 gii.4 NN cord-325712-9kbnyqt3 368 53 virus virus NN cord-325712-9kbnyqt3 368 54 - - HYPH cord-325712-9kbnyqt3 368 55 like like JJ cord-325712-9kbnyqt3 368 56 particles particle NNS cord-325712-9kbnyqt3 368 57 recognize recognize VBP cord-325712-9kbnyqt3 368 58 galactosylceramides galactosylceramide NNS cord-325712-9kbnyqt3 368 59 in in IN cord-325712-9kbnyqt3 368 60 domains domain NNS cord-325712-9kbnyqt3 368 61 of of IN cord-325712-9kbnyqt3 368 62 planar planar JJ cord-325712-9kbnyqt3 368 63 supported support VBN cord-325712-9kbnyqt3 368 64 lipid lipid NN cord-325712-9kbnyqt3 368 65 bilayers bilayer NNS cord-325712-9kbnyqt3 368 66 Single single JJ cord-325712-9kbnyqt3 368 67 - - HYPH cord-325712-9kbnyqt3 368 68 particle particle NN cord-325712-9kbnyqt3 368 69 fusion fusion NN cord-325712-9kbnyqt3 368 70 of of IN cord-325712-9kbnyqt3 368 71 influenza influenza NN cord-325712-9kbnyqt3 368 72 viruses virus NNS cord-325712-9kbnyqt3 368 73 reveals reveal VBZ cord-325712-9kbnyqt3 368 74 complex complex JJ cord-325712-9kbnyqt3 368 75 interactions interaction NNS cord-325712-9kbnyqt3 368 76 with with IN cord-325712-9kbnyqt3 368 77 target target NN cord-325712-9kbnyqt3 368 78 membranes membrane NNS cord-325712-9kbnyqt3 368 79 Preserved preserve VBN cord-325712-9kbnyqt3 368 80 transmembrane transmembrane NN cord-325712-9kbnyqt3 368 81 protein protein NN cord-325712-9kbnyqt3 368 82 mobility mobility NN cord-325712-9kbnyqt3 368 83 in in IN cord-325712-9kbnyqt3 368 84 polymer polymer NN cord-325712-9kbnyqt3 368 85 - - HYPH cord-325712-9kbnyqt3 368 86 supported support VBN cord-325712-9kbnyqt3 368 87 lipid lipid NN cord-325712-9kbnyqt3 368 88 bilayers bilayer NNS cord-325712-9kbnyqt3 368 89 derived derive VBN cord-325712-9kbnyqt3 368 90 from from IN cord-325712-9kbnyqt3 368 91 cell cell NN cord-325712-9kbnyqt3 368 92 membranes membrane NNS cord-325712-9kbnyqt3 368 93 Membrane membrane NN cord-325712-9kbnyqt3 368 94 protein protein NN cord-325712-9kbnyqt3 368 95 mobility mobility NN cord-325712-9kbnyqt3 368 96 and and CC cord-325712-9kbnyqt3 368 97 orientation orientation NN cord-325712-9kbnyqt3 368 98 preserved preserve VBN cord-325712-9kbnyqt3 368 99 in in IN cord-325712-9kbnyqt3 368 100 supported support VBN cord-325712-9kbnyqt3 368 101 bilayers bilayer NNS cord-325712-9kbnyqt3 368 102 created create VBN cord-325712-9kbnyqt3 368 103 directly directly RB cord-325712-9kbnyqt3 368 104 from from IN cord-325712-9kbnyqt3 368 105 cell cell NN cord-325712-9kbnyqt3 368 106 plasma plasma NN cord-325712-9kbnyqt3 368 107 membrane membrane NN cord-325712-9kbnyqt3 368 108 blebs blebs NN cord-325712-9kbnyqt3 368 109 Single single JJ cord-325712-9kbnyqt3 368 110 particle particle NN cord-325712-9kbnyqt3 368 111 tracking tracking NN cord-325712-9kbnyqt3 368 112 assay assay NN cord-325712-9kbnyqt3 368 113 to to TO cord-325712-9kbnyqt3 368 114 study study VB cord-325712-9kbnyqt3 368 115 coronavirus coronavirus NN cord-325712-9kbnyqt3 368 116 membrane membrane NN cord-325712-9kbnyqt3 368 117 fusion fusion NN cord-325712-9kbnyqt3 368 118 Biologically biologically RB cord-325712-9kbnyqt3 368 119 complex complex JJ cord-325712-9kbnyqt3 368 120 planar planar JJ cord-325712-9kbnyqt3 368 121 cell cell NN cord-325712-9kbnyqt3 368 122 plasma plasma NN cord-325712-9kbnyqt3 368 123 membranes membrane NNS cord-325712-9kbnyqt3 368 124 supported support VBN cord-325712-9kbnyqt3 368 125 on on IN cord-325712-9kbnyqt3 368 126 polyelectrolyte polyelectrolyte NNP cord-325712-9kbnyqt3 368 127 cushions cushion NNS cord-325712-9kbnyqt3 368 128 enhance enhance VBP cord-325712-9kbnyqt3 368 129 transmembrane transmembrane NN cord-325712-9kbnyqt3 368 130 protein protein NN cord-325712-9kbnyqt3 368 131 mobility mobility NN cord-325712-9kbnyqt3 368 132 and and CC cord-325712-9kbnyqt3 368 133 retain retain VB cord-325712-9kbnyqt3 368 134 native native JJ cord-325712-9kbnyqt3 368 135 orientation orientation NN cord-325712-9kbnyqt3 368 136 Physical physical JJ cord-325712-9kbnyqt3 368 137 properties property NNS cord-325712-9kbnyqt3 368 138 of of IN cord-325712-9kbnyqt3 368 139 single single JJ cord-325712-9kbnyqt3 368 140 phospholipid phospholipid NN cord-325712-9kbnyqt3 368 141 bilayers bilayer NNS cord-325712-9kbnyqt3 368 142 adsorbed adsorb VBN cord-325712-9kbnyqt3 368 143 to to IN cord-325712-9kbnyqt3 368 144 micro micro JJ cord-325712-9kbnyqt3 368 145 glass glass NN cord-325712-9kbnyqt3 368 146 beads bead NNS cord-325712-9kbnyqt3 368 147 . . . cord-325712-9kbnyqt3 369 1 A a DT cord-325712-9kbnyqt3 369 2 new new JJ cord-325712-9kbnyqt3 369 3 vesicular vesicular JJ cord-325712-9kbnyqt3 369 4 model model NN cord-325712-9kbnyqt3 369 5 system system NN cord-325712-9kbnyqt3 369 6 studied study VBN cord-325712-9kbnyqt3 369 7 by by IN cord-325712-9kbnyqt3 369 8 2H 2h JJ cord-325712-9kbnyqt3 369 9 - - HYPH cord-325712-9kbnyqt3 369 10 nuclear nuclear JJ cord-325712-9kbnyqt3 369 11 magnetic magnetic JJ cord-325712-9kbnyqt3 369 12 resonance resonance NN cord-325712-9kbnyqt3 369 13 Structure Structure NNP cord-325712-9kbnyqt3 369 14 of of IN cord-325712-9kbnyqt3 369 15 an an DT cord-325712-9kbnyqt3 369 16 adsorbed adsorb VBN cord-325712-9kbnyqt3 369 17 dimyristoylphosphatidylcholine dimyristoylphosphatidylcholine NN cord-325712-9kbnyqt3 369 18 bilayer bilayer NN cord-325712-9kbnyqt3 369 19 measured measure VBN cord-325712-9kbnyqt3 369 20 with with IN cord-325712-9kbnyqt3 369 21 specular specular JJ cord-325712-9kbnyqt3 369 22 reflection reflection NN cord-325712-9kbnyqt3 369 23 of of IN cord-325712-9kbnyqt3 369 24 neutrons neutron NNS cord-325712-9kbnyqt3 369 25 Anionic Anionic NNP cord-325712-9kbnyqt3 369 26 lipids lipid NNS cord-325712-9kbnyqt3 369 27 are be VBP cord-325712-9kbnyqt3 369 28 required require VBN cord-325712-9kbnyqt3 369 29 for for IN cord-325712-9kbnyqt3 369 30 vesicular vesicular JJ cord-325712-9kbnyqt3 369 31 stomatitis stomatitis NN cord-325712-9kbnyqt3 369 32 virus virus NN cord-325712-9kbnyqt3 369 33 G g NN cord-325712-9kbnyqt3 369 34 protein protein NN cord-325712-9kbnyqt3 369 35 - - HYPH cord-325712-9kbnyqt3 369 36 mediated mediate VBN cord-325712-9kbnyqt3 369 37 single single JJ cord-325712-9kbnyqt3 369 38 particle particle NN cord-325712-9kbnyqt3 369 39 fusion fusion NN cord-325712-9kbnyqt3 369 40 with with IN cord-325712-9kbnyqt3 369 41 supported support VBN cord-325712-9kbnyqt3 369 42 lipid lipid NN cord-325712-9kbnyqt3 369 43 bilayers bilayer NNS cord-325712-9kbnyqt3 370 1 A a DT cord-325712-9kbnyqt3 370 2 review review NN cord-325712-9kbnyqt3 370 3 of of IN cord-325712-9kbnyqt3 370 4 traditional traditional JJ cord-325712-9kbnyqt3 370 5 and and CC cord-325712-9kbnyqt3 370 6 emerging emerge VBG cord-325712-9kbnyqt3 370 7 methods method NNS cord-325712-9kbnyqt3 370 8 to to TO cord-325712-9kbnyqt3 370 9 characterize characterize VB cord-325712-9kbnyqt3 370 10 lipid lipid NN cord-325712-9kbnyqt3 370 11 - - HYPH cord-325712-9kbnyqt3 370 12 protein protein NN cord-325712-9kbnyqt3 370 13 interactions interaction NNS cord-325712-9kbnyqt3 370 14 in in IN cord-325712-9kbnyqt3 370 15 biological biological JJ cord-325712-9kbnyqt3 370 16 membranes membrane NNS cord-325712-9kbnyqt3 370 17 Membrane membrane NN cord-325712-9kbnyqt3 370 18 fusion fusion NN cord-325712-9kbnyqt3 370 19 - - HYPH cord-325712-9kbnyqt3 370 20 competent competent JJ cord-325712-9kbnyqt3 370 21 virus virus NN cord-325712-9kbnyqt3 370 22 - - HYPH cord-325712-9kbnyqt3 370 23 like like JJ cord-325712-9kbnyqt3 370 24 proteoliposomes proteoliposome NNS cord-325712-9kbnyqt3 370 25 and and CC cord-325712-9kbnyqt3 370 26 proteinaceous proteinaceous JJ cord-325712-9kbnyqt3 370 27 supported support VBN cord-325712-9kbnyqt3 370 28 bilayers bilayer NNS cord-325712-9kbnyqt3 370 29 made make VBN cord-325712-9kbnyqt3 370 30 directly directly RB cord-325712-9kbnyqt3 370 31 from from IN cord-325712-9kbnyqt3 370 32 cell cell NN cord-325712-9kbnyqt3 370 33 plasma plasma NN cord-325712-9kbnyqt3 370 34 membranes membrane NNS cord-325712-9kbnyqt3 370 35 Reconstitution Reconstitution NNP cord-325712-9kbnyqt3 370 36 of of IN cord-325712-9kbnyqt3 370 37 membrane membrane NN cord-325712-9kbnyqt3 370 38 fusion fusion NN cord-325712-9kbnyqt3 370 39 sites site NNS cord-325712-9kbnyqt3 370 40 Influenza Influenza NNP cord-325712-9kbnyqt3 370 41 hemagglutinin hemagglutinin NN cord-325712-9kbnyqt3 370 42 assumes assume VBZ cord-325712-9kbnyqt3 370 43 a a DT cord-325712-9kbnyqt3 370 44 tilted tilted JJ cord-325712-9kbnyqt3 370 45 conformation conformation NN cord-325712-9kbnyqt3 370 46 during during IN cord-325712-9kbnyqt3 370 47 membrane membrane NN cord-325712-9kbnyqt3 370 48 fusion fusion NN cord-325712-9kbnyqt3 370 49 as as IN cord-325712-9kbnyqt3 370 50 determined determine VBN cord-325712-9kbnyqt3 370 51 by by IN cord-325712-9kbnyqt3 370 52 attenuated attenuated JJ cord-325712-9kbnyqt3 370 53 total total JJ cord-325712-9kbnyqt3 370 54 reflection reflection NN cord-325712-9kbnyqt3 370 55 FTIR FTIR NNP cord-325712-9kbnyqt3 370 56 spectroscopy spectroscopy NN cord-325712-9kbnyqt3 370 57 Receptor receptor NN cord-325712-9kbnyqt3 370 58 concentration concentration NN cord-325712-9kbnyqt3 370 59 and and CC cord-325712-9kbnyqt3 370 60 diffusivity diffusivity NN cord-325712-9kbnyqt3 370 61 control control NN cord-325712-9kbnyqt3 370 62 multivalent multivalent JJ cord-325712-9kbnyqt3 370 63 binding binding NN cord-325712-9kbnyqt3 370 64 of of IN cord-325712-9kbnyqt3 370 65 Sv40 Sv40 NNP cord-325712-9kbnyqt3 370 66 to to TO cord-325712-9kbnyqt3 370 67 membrane membrane NN cord-325712-9kbnyqt3 370 68 bilayers bilayer NNS cord-325712-9kbnyqt3 370 69 Cell cell NN cord-325712-9kbnyqt3 370 70 - - HYPH cord-325712-9kbnyqt3 370 71 to to IN cord-325712-9kbnyqt3 370 72 - - HYPH cord-325712-9kbnyqt3 370 73 cell cell NN cord-325712-9kbnyqt3 370 74 transfer transfer NN cord-325712-9kbnyqt3 370 75 of of IN cord-325712-9kbnyqt3 370 76 HIV-1 HIV-1 NNP cord-325712-9kbnyqt3 370 77 via via IN cord-325712-9kbnyqt3 370 78 virological virological JJ cord-325712-9kbnyqt3 370 79 synapses synapsis NNS cord-325712-9kbnyqt3 370 80 leads lead VBZ cord-325712-9kbnyqt3 370 81 to to IN cord-325712-9kbnyqt3 370 82 endosomal endosomal NNP cord-325712-9kbnyqt3 370 83 virion virion NN cord-325712-9kbnyqt3 370 84 maturation maturation NN cord-325712-9kbnyqt3 370 85 that that WDT cord-325712-9kbnyqt3 370 86 activates activate VBZ cord-325712-9kbnyqt3 370 87 viral viral JJ cord-325712-9kbnyqt3 370 88 membrane membrane NN cord-325712-9kbnyqt3 370 89 fusion fusion NN cord-325712-9kbnyqt3 370 90 3D 3d JJ cord-325712-9kbnyqt3 370 91 visualization visualization NN cord-325712-9kbnyqt3 370 92 of of IN cord-325712-9kbnyqt3 370 93 HIV HIV NNP cord-325712-9kbnyqt3 370 94 transfer transfer NN cord-325712-9kbnyqt3 370 95 at at IN cord-325712-9kbnyqt3 370 96 the the DT cord-325712-9kbnyqt3 370 97 virological virological JJ cord-325712-9kbnyqt3 370 98 synapse synapse NN cord-325712-9kbnyqt3 370 99 between between IN cord-325712-9kbnyqt3 370 100 dendritic dendritic JJ cord-325712-9kbnyqt3 370 101 cells cell NNS cord-325712-9kbnyqt3 370 102 and and CC cord-325712-9kbnyqt3 370 103 T t NN cord-325712-9kbnyqt3 370 104 cells cell NNS cord-325712-9kbnyqt3 370 105 Quantitative quantitative JJ cord-325712-9kbnyqt3 370 106 3D 3d JJ cord-325712-9kbnyqt3 370 107 video video NN cord-325712-9kbnyqt3 370 108 microscopy microscopy NNS cord-325712-9kbnyqt3 370 109 of of IN cord-325712-9kbnyqt3 370 110 HIV HIV NNP cord-325712-9kbnyqt3 370 111 transfer transfer NN cord-325712-9kbnyqt3 370 112 across across IN cord-325712-9kbnyqt3 370 113 T t NN cord-325712-9kbnyqt3 370 114 cell cell NN cord-325712-9kbnyqt3 370 115 virological virological JJ cord-325712-9kbnyqt3 370 116 synapses synapsis NNS cord-325712-9kbnyqt3 370 117 Actin Actin NNP cord-325712-9kbnyqt3 370 118 - - HYPH cord-325712-9kbnyqt3 370 119 based base VBN cord-325712-9kbnyqt3 370 120 motility motility NN cord-325712-9kbnyqt3 370 121 of of IN cord-325712-9kbnyqt3 370 122 vaccinia vaccinia NN cord-325712-9kbnyqt3 370 123 virus virus NN cord-325712-9kbnyqt3 371 1 Imaging image VBG cord-325712-9kbnyqt3 371 2 the the DT cord-325712-9kbnyqt3 371 3 transport transport NN cord-325712-9kbnyqt3 371 4 dynamics dynamic NNS cord-325712-9kbnyqt3 371 5 of of IN cord-325712-9kbnyqt3 371 6 single single JJ cord-325712-9kbnyqt3 371 7 alphaherpesvirus alphaherpesvirus NN cord-325712-9kbnyqt3 371 8 particles particle NNS cord-325712-9kbnyqt3 371 9 in in IN cord-325712-9kbnyqt3 371 10 intact intact JJ cord-325712-9kbnyqt3 371 11 peripheral peripheral JJ cord-325712-9kbnyqt3 371 12 nervous nervous JJ cord-325712-9kbnyqt3 371 13 system system NN cord-325712-9kbnyqt3 371 14 explants explant NNS cord-325712-9kbnyqt3 371 15 from from IN cord-325712-9kbnyqt3 371 16 infected infected JJ cord-325712-9kbnyqt3 371 17 mice mouse NNS cord-325712-9kbnyqt3 371 18 Immobilization immobilization NN cord-325712-9kbnyqt3 371 19 of of IN cord-325712-9kbnyqt3 371 20 pseudorabies pseudorabies NN cord-325712-9kbnyqt3 371 21 virus virus NN cord-325712-9kbnyqt3 371 22 in in IN cord-325712-9kbnyqt3 371 23 porcine porcine JJ cord-325712-9kbnyqt3 371 24 tracheal tracheal JJ cord-325712-9kbnyqt3 371 25 respiratory respiratory JJ cord-325712-9kbnyqt3 371 26 mucus mucus NN cord-325712-9kbnyqt3 371 27 revealed reveal VBN cord-325712-9kbnyqt3 371 28 by by IN cord-325712-9kbnyqt3 371 29 single single JJ cord-325712-9kbnyqt3 371 30 particle particle NN cord-325712-9kbnyqt3 371 31 tracking track VBG cord-325712-9kbnyqt3 371 32 Actin Actin NNP cord-325712-9kbnyqt3 371 33 - - HYPH cord-325712-9kbnyqt3 371 34 and and CC cord-325712-9kbnyqt3 371 35 myosin myosin NN cord-325712-9kbnyqt3 371 36 - - HYPH cord-325712-9kbnyqt3 371 37 driven drive VBN cord-325712-9kbnyqt3 371 38 movement movement NN cord-325712-9kbnyqt3 371 39 of of IN cord-325712-9kbnyqt3 371 40 viruses virus NNS cord-325712-9kbnyqt3 371 41 along along IN cord-325712-9kbnyqt3 371 42 filopodia filopodia NNS cord-325712-9kbnyqt3 371 43 precedes precede VBZ cord-325712-9kbnyqt3 371 44 their -PRON- PRP$ cord-325712-9kbnyqt3 371 45 entry entry NN cord-325712-9kbnyqt3 371 46 into into IN cord-325712-9kbnyqt3 371 47 cells cell NNS cord-325712-9kbnyqt3 371 48 Dissecting dissect VBG cord-325712-9kbnyqt3 371 49 the the DT cord-325712-9kbnyqt3 371 50 cell cell NN cord-325712-9kbnyqt3 371 51 entry entry NN cord-325712-9kbnyqt3 371 52 pathway pathway NN cord-325712-9kbnyqt3 371 53 of of IN cord-325712-9kbnyqt3 371 54 dengue dengue NN cord-325712-9kbnyqt3 371 55 virus virus NN cord-325712-9kbnyqt3 371 56 by by IN cord-325712-9kbnyqt3 371 57 single single JJ cord-325712-9kbnyqt3 371 58 - - HYPH cord-325712-9kbnyqt3 371 59 particle particle NN cord-325712-9kbnyqt3 371 60 tracking tracking NN cord-325712-9kbnyqt3 371 61 in in IN cord-325712-9kbnyqt3 371 62 living living NN cord-325712-9kbnyqt3 371 63 cells cell NNS cord-325712-9kbnyqt3 371 64 Local local JJ cord-325712-9kbnyqt3 371 65 actin actin NN cord-325712-9kbnyqt3 371 66 polymerization polymerization NN cord-325712-9kbnyqt3 371 67 and and CC cord-325712-9kbnyqt3 371 68 dynamin dynamin NN cord-325712-9kbnyqt3 371 69 recruitment recruitment NN cord-325712-9kbnyqt3 371 70 in in IN cord-325712-9kbnyqt3 371 71 SV40-induced SV40-induced NNP cord-325712-9kbnyqt3 371 72 internalization internalization NN cord-325712-9kbnyqt3 371 73 of of IN cord-325712-9kbnyqt3 371 74 caveolae caveolae NNP cord-325712-9kbnyqt3 371 75 Single single JJ cord-325712-9kbnyqt3 371 76 - - HYPH cord-325712-9kbnyqt3 371 77 particle particle NN cord-325712-9kbnyqt3 371 78 tracking tracking NN cord-325712-9kbnyqt3 371 79 of of IN cord-325712-9kbnyqt3 371 80 murine murine JJ cord-325712-9kbnyqt3 371 81 polyoma polyoma JJ cord-325712-9kbnyqt3 371 82 virus virus NN cord-325712-9kbnyqt3 371 83 - - HYPH cord-325712-9kbnyqt3 371 84 like like JJ cord-325712-9kbnyqt3 371 85 particles particle NNS cord-325712-9kbnyqt3 371 86 on on IN cord-325712-9kbnyqt3 371 87 live live JJ cord-325712-9kbnyqt3 371 88 cells cell NNS cord-325712-9kbnyqt3 371 89 and and CC cord-325712-9kbnyqt3 371 90 artificial artificial JJ cord-325712-9kbnyqt3 371 91 membranes membrane NNS cord-325712-9kbnyqt3 371 92 Vaccinia Vaccinia NNP cord-325712-9kbnyqt3 371 93 virus virus NN cord-325712-9kbnyqt3 371 94 uses use VBZ cord-325712-9kbnyqt3 371 95 macropinocytosis macropinocytosis NN cord-325712-9kbnyqt3 371 96 and and CC cord-325712-9kbnyqt3 371 97 apoptotic apoptotic JJ cord-325712-9kbnyqt3 371 98 mimicry mimicry NN cord-325712-9kbnyqt3 371 99 to to TO cord-325712-9kbnyqt3 371 100 enter enter VB cord-325712-9kbnyqt3 371 101 host host NN cord-325712-9kbnyqt3 371 102 cells cell NNS cord-325712-9kbnyqt3 371 103 Real real JJ cord-325712-9kbnyqt3 371 104 - - HYPH cord-325712-9kbnyqt3 371 105 time time NN cord-325712-9kbnyqt3 371 106 imaging imaging NN cord-325712-9kbnyqt3 371 107 of of IN cord-325712-9kbnyqt3 371 108 rabies rabies NN cord-325712-9kbnyqt3 371 109 virus virus NN cord-325712-9kbnyqt3 371 110 entry entry NN cord-325712-9kbnyqt3 371 111 into into IN cord-325712-9kbnyqt3 371 112 living live VBG cord-325712-9kbnyqt3 371 113 vero vero NNP cord-325712-9kbnyqt3 371 114 cells cell NNS cord-325712-9kbnyqt3 371 115 Drifting drift VBG cord-325712-9kbnyqt3 371 116 motions motion NNS cord-325712-9kbnyqt3 371 117 of of IN cord-325712-9kbnyqt3 371 118 the the DT cord-325712-9kbnyqt3 371 119 adenovirus adenovirus NN cord-325712-9kbnyqt3 371 120 receptor receptor NN cord-325712-9kbnyqt3 371 121 CAR car NN cord-325712-9kbnyqt3 371 122 and and CC cord-325712-9kbnyqt3 371 123 immobile immobile JJ cord-325712-9kbnyqt3 371 124 integrins integrin NNS cord-325712-9kbnyqt3 371 125 initiate initiate VBP cord-325712-9kbnyqt3 371 126 virus virus NN cord-325712-9kbnyqt3 371 127 uncoating uncoating NN cord-325712-9kbnyqt3 371 128 and and CC cord-325712-9kbnyqt3 371 129 membrane membrane NN cord-325712-9kbnyqt3 371 130 lytic lytic JJ cord-325712-9kbnyqt3 371 131 protein protein NN cord-325712-9kbnyqt3 371 132 exposure exposure NN cord-325712-9kbnyqt3 372 1 A a DT cord-325712-9kbnyqt3 372 2 novel novel JJ cord-325712-9kbnyqt3 372 3 supervised supervise VBN cord-325712-9kbnyqt3 372 4 trajectory trajectory NN cord-325712-9kbnyqt3 372 5 segmentation segmentation NN cord-325712-9kbnyqt3 372 6 algorithm algorithm NN cord-325712-9kbnyqt3 372 7 identifies identify VBZ cord-325712-9kbnyqt3 372 8 distinct distinct JJ cord-325712-9kbnyqt3 372 9 types type NNS cord-325712-9kbnyqt3 372 10 of of IN cord-325712-9kbnyqt3 372 11 human human JJ cord-325712-9kbnyqt3 372 12 adenovirus adenovirus NN cord-325712-9kbnyqt3 372 13 motion motion NN cord-325712-9kbnyqt3 372 14 in in IN cord-325712-9kbnyqt3 372 15 host host NN cord-325712-9kbnyqt3 372 16 cells cell NNS cord-325712-9kbnyqt3 372 17 Virus virus NN cord-325712-9kbnyqt3 372 18 - - HYPH cord-325712-9kbnyqt3 372 19 induced induce VBN cord-325712-9kbnyqt3 372 20 Abl Abl NNP cord-325712-9kbnyqt3 372 21 and and CC cord-325712-9kbnyqt3 372 22 Fyn Fyn NNP cord-325712-9kbnyqt3 372 23 kinase kinase NN cord-325712-9kbnyqt3 372 24 signals signal VBZ cord-325712-9kbnyqt3 372 25 permit permit VBP cord-325712-9kbnyqt3 372 26 coxsackievirus coxsackievirus NN cord-325712-9kbnyqt3 372 27 entry entry NN cord-325712-9kbnyqt3 372 28 through through IN cord-325712-9kbnyqt3 372 29 epithelial epithelial JJ cord-325712-9kbnyqt3 372 30 tight tight JJ cord-325712-9kbnyqt3 372 31 junctions junction NNS cord-325712-9kbnyqt3 372 32 Assembly Assembly NNP cord-325712-9kbnyqt3 372 33 of of IN cord-325712-9kbnyqt3 372 34 endocytic endocytic JJ cord-325712-9kbnyqt3 372 35 machinery machinery NN cord-325712-9kbnyqt3 372 36 around around IN cord-325712-9kbnyqt3 372 37 individual individual JJ cord-325712-9kbnyqt3 372 38 influenza influenza NN cord-325712-9kbnyqt3 372 39 viruses virus NNS cord-325712-9kbnyqt3 372 40 during during IN cord-325712-9kbnyqt3 372 41 viral viral JJ cord-325712-9kbnyqt3 372 42 entry entry NN cord-325712-9kbnyqt3 372 43 Binding bind VBG cord-325712-9kbnyqt3 372 44 kinetics kinetic NNS cord-325712-9kbnyqt3 372 45 and and CC cord-325712-9kbnyqt3 372 46 lateral lateral JJ cord-325712-9kbnyqt3 372 47 mobility mobility NN cord-325712-9kbnyqt3 372 48 of of IN cord-325712-9kbnyqt3 372 49 HSV-1 hsv-1 NN cord-325712-9kbnyqt3 372 50 on on IN cord-325712-9kbnyqt3 372 51 end end NN cord-325712-9kbnyqt3 372 52 - - HYPH cord-325712-9kbnyqt3 372 53 grafted graft VBN cord-325712-9kbnyqt3 372 54 sulfated sulfated JJ cord-325712-9kbnyqt3 372 55 glycosaminoglycans glycosaminoglycans NN cord-325712-9kbnyqt3 372 56 Equilibrium equilibrium NN cord-325712-9kbnyqt3 372 57 - - HYPH cord-325712-9kbnyqt3 372 58 fluctuation fluctuation NN cord-325712-9kbnyqt3 372 59 - - HYPH cord-325712-9kbnyqt3 372 60 analysis analysis NN cord-325712-9kbnyqt3 372 61 of of IN cord-325712-9kbnyqt3 372 62 single single JJ cord-325712-9kbnyqt3 372 63 liposome liposome NN cord-325712-9kbnyqt3 372 64 binding bind VBG cord-325712-9kbnyqt3 372 65 events event NNS cord-325712-9kbnyqt3 372 66 reveals reveal VBZ cord-325712-9kbnyqt3 372 67 how how WRB cord-325712-9kbnyqt3 372 68 cholesterol cholesterol NN cord-325712-9kbnyqt3 372 69 and and CC cord-325712-9kbnyqt3 372 70 Ca2 ca2 NN cord-325712-9kbnyqt3 372 71 + + CC cord-325712-9kbnyqt3 372 72 modulate modulate VB cord-325712-9kbnyqt3 372 73 glycosphingolipid glycosphingolipid NNP cord-325712-9kbnyqt3 372 74 trans tran NNS cord-325712-9kbnyqt3 372 75 - - NNS cord-325712-9kbnyqt3 372 76 interactions interaction NNS cord-325712-9kbnyqt3 372 77 Interaction Interaction NNP cord-325712-9kbnyqt3 372 78 of of IN cord-325712-9kbnyqt3 372 79 single single JJ cord-325712-9kbnyqt3 372 80 viruslike viruslike JJ cord-325712-9kbnyqt3 372 81 particles particle NNS cord-325712-9kbnyqt3 372 82 with with IN cord-325712-9kbnyqt3 372 83 vesicles vesicle NNS cord-325712-9kbnyqt3 372 84 containing contain VBG cord-325712-9kbnyqt3 372 85 glycosphingolipids glycosphingolipid NNS cord-325712-9kbnyqt3 372 86 A a DT cord-325712-9kbnyqt3 372 87 virus virus NN cord-325712-9kbnyqt3 372 88 biosensor biosensor NN cord-325712-9kbnyqt3 372 89 with with IN cord-325712-9kbnyqt3 372 90 single single JJ cord-325712-9kbnyqt3 372 91 virus virus NN cord-325712-9kbnyqt3 372 92 - - HYPH cord-325712-9kbnyqt3 372 93 particle particle NN cord-325712-9kbnyqt3 372 94 sensitivity sensitivity NN cord-325712-9kbnyqt3 372 95 based base VBN cord-325712-9kbnyqt3 372 96 on on IN cord-325712-9kbnyqt3 372 97 fluorescent fluorescent JJ cord-325712-9kbnyqt3 372 98 vesicle vesicle NN cord-325712-9kbnyqt3 372 99 labels label NNS cord-325712-9kbnyqt3 372 100 and and CC cord-325712-9kbnyqt3 372 101 equilibrium equilibrium NN cord-325712-9kbnyqt3 372 102 fluctuation fluctuation NN cord-325712-9kbnyqt3 372 103 analysis analysis NN cord-325712-9kbnyqt3 372 104 Interaction Interaction NNP cord-325712-9kbnyqt3 372 105 of of IN cord-325712-9kbnyqt3 372 106 virus virus NN cord-325712-9kbnyqt3 372 107 - - HYPH cord-325712-9kbnyqt3 372 108 like like JJ cord-325712-9kbnyqt3 372 109 particles particle NNS cord-325712-9kbnyqt3 372 110 with with IN cord-325712-9kbnyqt3 372 111 vesicles vesicle NNS cord-325712-9kbnyqt3 372 112 containing contain VBG cord-325712-9kbnyqt3 372 113 glycolipids glycolipid NNS cord-325712-9kbnyqt3 372 114 : : : cord-325712-9kbnyqt3 372 115 kinetics kinetic NNS cord-325712-9kbnyqt3 372 116 of of IN cord-325712-9kbnyqt3 372 117 detachment detachment NN cord-325712-9kbnyqt3 372 118 Quantification quantification NN cord-325712-9kbnyqt3 372 119 of of IN cord-325712-9kbnyqt3 372 120 multivalent multivalent JJ cord-325712-9kbnyqt3 372 121 interactions interaction NNS cord-325712-9kbnyqt3 372 122 by by IN cord-325712-9kbnyqt3 372 123 tracking track VBG cord-325712-9kbnyqt3 372 124 single single JJ cord-325712-9kbnyqt3 372 125 biological biological JJ cord-325712-9kbnyqt3 372 126 nanoparticle nanoparticle NN cord-325712-9kbnyqt3 372 127 mobility mobility NN cord-325712-9kbnyqt3 372 128 on on IN cord-325712-9kbnyqt3 372 129 a a DT cord-325712-9kbnyqt3 372 130 lipid lipid NN cord-325712-9kbnyqt3 372 131 membrane membrane NN cord-325712-9kbnyqt3 372 132 Single single JJ cord-325712-9kbnyqt3 372 133 - - HYPH cord-325712-9kbnyqt3 372 134 particle particle NN cord-325712-9kbnyqt3 372 135 tracking tracking NN cord-325712-9kbnyqt3 372 136 shows show VBZ cord-325712-9kbnyqt3 372 137 that that IN cord-325712-9kbnyqt3 372 138 a a DT cord-325712-9kbnyqt3 372 139 point point NN cord-325712-9kbnyqt3 372 140 mutation mutation NN cord-325712-9kbnyqt3 372 141 in in IN cord-325712-9kbnyqt3 372 142 the the DT cord-325712-9kbnyqt3 372 143 carnivore carnivore NN cord-325712-9kbnyqt3 372 144 parvovirus parvovirus NN cord-325712-9kbnyqt3 372 145 capsid capsid NN cord-325712-9kbnyqt3 372 146 switches switch VBZ cord-325712-9kbnyqt3 372 147 binding bind VBG cord-325712-9kbnyqt3 372 148 between between IN cord-325712-9kbnyqt3 372 149 host host NN cord-325712-9kbnyqt3 372 150 - - HYPH cord-325712-9kbnyqt3 372 151 specific specific JJ cord-325712-9kbnyqt3 372 152 transferrin transferrin NN cord-325712-9kbnyqt3 372 153 receptors receptor NNS cord-325712-9kbnyqt3 373 1 HIV HIV NNP cord-325712-9kbnyqt3 373 2 gp41-mediated gp41-mediated NNP cord-325712-9kbnyqt3 373 3 membrane membrane NN cord-325712-9kbnyqt3 373 4 fusion fusion NN cord-325712-9kbnyqt3 373 5 occurs occur VBZ cord-325712-9kbnyqt3 373 6 at at IN cord-325712-9kbnyqt3 373 7 edges edge NNS cord-325712-9kbnyqt3 373 8 of of IN cord-325712-9kbnyqt3 373 9 cholesterol cholesterol NN cord-325712-9kbnyqt3 373 10 - - HYPH cord-325712-9kbnyqt3 373 11 rich rich JJ cord-325712-9kbnyqt3 373 12 lipid lipid NN cord-325712-9kbnyqt3 373 13 domains domain NNS cord-325712-9kbnyqt3 373 14 HIV HIV NNP cord-325712-9kbnyqt3 373 15 virions virion NNS cord-325712-9kbnyqt3 373 16 sense sense VBP cord-325712-9kbnyqt3 373 17 plasma plasma NN cord-325712-9kbnyqt3 373 18 membrane membrane NN cord-325712-9kbnyqt3 373 19 heterogeneity heterogeneity NN cord-325712-9kbnyqt3 373 20 for for IN cord-325712-9kbnyqt3 373 21 cell cell NN cord-325712-9kbnyqt3 373 22 entry entry NN cord-325712-9kbnyqt3 373 23 Gp120 gp120 NN cord-325712-9kbnyqt3 373 24 binds bind VBZ cord-325712-9kbnyqt3 373 25 cooperatively cooperatively RB cord-325712-9kbnyqt3 373 26 to to IN cord-325712-9kbnyqt3 373 27 several several JJ cord-325712-9kbnyqt3 373 28 biologically biologically RB cord-325712-9kbnyqt3 373 29 relevant relevant JJ cord-325712-9kbnyqt3 373 30 glycosphingolipids glycosphingolipid NNS cord-325712-9kbnyqt3 373 31 : : : cord-325712-9kbnyqt3 373 32 quantitative quantitative JJ cord-325712-9kbnyqt3 373 33 measurements measurement NNS cord-325712-9kbnyqt3 373 34 at at IN cord-325712-9kbnyqt3 373 35 equilibrium equilibrium NN cord-325712-9kbnyqt3 373 36 by by IN cord-325712-9kbnyqt3 373 37 total total JJ cord-325712-9kbnyqt3 373 38 internal internal JJ cord-325712-9kbnyqt3 373 39 reflection reflection NN cord-325712-9kbnyqt3 373 40 fluorescence fluorescence NN cord-325712-9kbnyqt3 373 41 microscopy microscopy NN cord-325712-9kbnyqt3 374 1 Quantitative quantitative JJ cord-325712-9kbnyqt3 374 2 measurements measurement NNS cord-325712-9kbnyqt3 374 3 of of IN cord-325712-9kbnyqt3 374 4 recombinant recombinant JJ cord-325712-9kbnyqt3 374 5 HIV HIV NNP cord-325712-9kbnyqt3 374 6 surface surface NN cord-325712-9kbnyqt3 374 7 glycoprotein glycoprotein NN cord-325712-9kbnyqt3 374 8 120 120 CD cord-325712-9kbnyqt3 374 9 binding bind VBG cord-325712-9kbnyqt3 374 10 to to IN cord-325712-9kbnyqt3 374 11 several several JJ cord-325712-9kbnyqt3 374 12 glycosphingolipids glycosphingolipid NNS cord-325712-9kbnyqt3 374 13 expressed express VBN cord-325712-9kbnyqt3 374 14 in in IN cord-325712-9kbnyqt3 374 15 planar planar JJ cord-325712-9kbnyqt3 374 16 supported support VBN cord-325712-9kbnyqt3 374 17 lipid lipid NN cord-325712-9kbnyqt3 374 18 bilayers bilayer NNS cord-325712-9kbnyqt3 374 19 Energetics Energetics NNP cord-325712-9kbnyqt3 374 20 of of IN cord-325712-9kbnyqt3 374 21 the the DT cord-325712-9kbnyqt3 374 22 HIV HIV NNP cord-325712-9kbnyqt3 374 23 gp120-CD4 gp120-CD4 NNP cord-325712-9kbnyqt3 374 24 binding binding NN cord-325712-9kbnyqt3 374 25 reaction reaction NN cord-325712-9kbnyqt3 374 26 Role role NN cord-325712-9kbnyqt3 374 27 of of IN cord-325712-9kbnyqt3 374 28 cholesterol cholesterol NN cord-325712-9kbnyqt3 374 29 in in IN cord-325712-9kbnyqt3 374 30 fusion fusion NN cord-325712-9kbnyqt3 374 31 of of IN cord-325712-9kbnyqt3 374 32 Semliki Semliki NNP cord-325712-9kbnyqt3 374 33 forest forest NN cord-325712-9kbnyqt3 374 34 virus virus NN cord-325712-9kbnyqt3 374 35 with with IN cord-325712-9kbnyqt3 374 36 membranes membrane NNS cord-325712-9kbnyqt3 374 37 Membrane membrane NN cord-325712-9kbnyqt3 374 38 fusion fusion NN cord-325712-9kbnyqt3 374 39 of of IN cord-325712-9kbnyqt3 374 40 Semliki Semliki NNP cord-325712-9kbnyqt3 374 41 forest forest NN cord-325712-9kbnyqt3 374 42 virus virus NN cord-325712-9kbnyqt3 374 43 involves involve VBZ cord-325712-9kbnyqt3 374 44 homotrimers homotrimer NNS cord-325712-9kbnyqt3 374 45 of of IN cord-325712-9kbnyqt3 374 46 the the DT cord-325712-9kbnyqt3 374 47 fusion fusion NN cord-325712-9kbnyqt3 374 48 protein protein NN cord-325712-9kbnyqt3 374 49 Structure Structure NNP cord-325712-9kbnyqt3 374 50 and and CC cord-325712-9kbnyqt3 374 51 receptor receptor NN cord-325712-9kbnyqt3 374 52 specificity specificity NN cord-325712-9kbnyqt3 374 53 of of IN cord-325712-9kbnyqt3 374 54 the the DT cord-325712-9kbnyqt3 374 55 hemagglutinin hemagglutinin NN cord-325712-9kbnyqt3 374 56 from from IN cord-325712-9kbnyqt3 374 57 an an DT cord-325712-9kbnyqt3 374 58 H5N1 H5N1 NNP cord-325712-9kbnyqt3 374 59 influenza influenza NN cord-325712-9kbnyqt3 374 60 virus virus NN cord-325712-9kbnyqt3 374 61 Binding bind VBG cord-325712-9kbnyqt3 374 62 kinetics kinetic NNS cord-325712-9kbnyqt3 374 63 of of IN cord-325712-9kbnyqt3 374 64 influenza influenza NN cord-325712-9kbnyqt3 374 65 viruses virus NNS cord-325712-9kbnyqt3 374 66 to to IN cord-325712-9kbnyqt3 374 67 sialic sialic JJ cord-325712-9kbnyqt3 374 68 acid acid NN cord-325712-9kbnyqt3 374 69 - - HYPH cord-325712-9kbnyqt3 374 70 containing contain VBG cord-325712-9kbnyqt3 374 71 carbohydrates carbohydrate NNS cord-325712-9kbnyqt3 374 72 QCM QCM NNP cord-325712-9kbnyqt3 374 73 - - HYPH cord-325712-9kbnyqt3 374 74 D D NNP cord-325712-9kbnyqt3 374 75 studies study NNS cord-325712-9kbnyqt3 374 76 of of IN cord-325712-9kbnyqt3 375 1 human human JJ cord-325712-9kbnyqt3 375 2 norovirus norovirus NN cord-325712-9kbnyqt3 375 3 VLPs vlp NNS cord-325712-9kbnyqt3 375 4 binding bind VBG cord-325712-9kbnyqt3 375 5 to to IN cord-325712-9kbnyqt3 375 6 glycosphingolipids glycosphingolipid NNS cord-325712-9kbnyqt3 375 7 in in IN cord-325712-9kbnyqt3 375 8 supported support VBN cord-325712-9kbnyqt3 375 9 lipid lipid NN cord-325712-9kbnyqt3 375 10 bilayers bilayer NNS cord-325712-9kbnyqt3 375 11 reveal reveal VBP cord-325712-9kbnyqt3 375 12 strain strain NN cord-325712-9kbnyqt3 375 13 - - HYPH cord-325712-9kbnyqt3 375 14 specific specific JJ cord-325712-9kbnyqt3 375 15 characteristics characteristic NNS cord-325712-9kbnyqt3 375 16 Single single JJ cord-325712-9kbnyqt3 375 17 - - HYPH cord-325712-9kbnyqt3 375 18 molecule molecule NN cord-325712-9kbnyqt3 375 19 fluorescence fluorescence NN cord-325712-9kbnyqt3 375 20 imaging imaging NN cord-325712-9kbnyqt3 375 21 : : : cord-325712-9kbnyqt3 375 22 generating generate VBG cord-325712-9kbnyqt3 375 23 insights insight NNS cord-325712-9kbnyqt3 375 24 into into IN cord-325712-9kbnyqt3 375 25 molecular molecular JJ cord-325712-9kbnyqt3 375 26 interactions interaction NNS cord-325712-9kbnyqt3 375 27 in in IN cord-325712-9kbnyqt3 375 28 virology virology NN cord-325712-9kbnyqt3 375 29 Endocytosis endocytosis NN cord-325712-9kbnyqt3 375 30 by by IN cord-325712-9kbnyqt3 375 31 random random JJ cord-325712-9kbnyqt3 375 32 initiation initiation NN cord-325712-9kbnyqt3 375 33 and and CC cord-325712-9kbnyqt3 375 34 stabilization stabilization NN cord-325712-9kbnyqt3 375 35 of of IN cord-325712-9kbnyqt3 375 36 clathrin clathrin NN cord-325712-9kbnyqt3 375 37 - - HYPH cord-325712-9kbnyqt3 375 38 coated coat VBN cord-325712-9kbnyqt3 375 39 pits pit NNS cord-325712-9kbnyqt3 375 40 Echovirus Echovirus NNP cord-325712-9kbnyqt3 375 41 1 1 CD cord-325712-9kbnyqt3 375 42 endocytosis endocytosis NN cord-325712-9kbnyqt3 375 43 into into IN cord-325712-9kbnyqt3 375 44 caveosomes caveosome NNS cord-325712-9kbnyqt3 375 45 requires require VBZ cord-325712-9kbnyqt3 375 46 lipid lipid NN cord-325712-9kbnyqt3 375 47 rafts raft NNS cord-325712-9kbnyqt3 375 48 , , , cord-325712-9kbnyqt3 375 49 dynamin dynamin NNP cord-325712-9kbnyqt3 375 50 II II NNP cord-325712-9kbnyqt3 375 51 , , , cord-325712-9kbnyqt3 375 52 and and CC cord-325712-9kbnyqt3 375 53 signaling signal VBG cord-325712-9kbnyqt3 375 54 events event NNS cord-325712-9kbnyqt3 375 55 Host Host NNP cord-325712-9kbnyqt3 375 56 cell cell NN cord-325712-9kbnyqt3 375 57 virus virus NN cord-325712-9kbnyqt3 375 58 entry entry NN cord-325712-9kbnyqt3 375 59 mediated mediate VBN cord-325712-9kbnyqt3 375 60 by by IN cord-325712-9kbnyqt3 375 61 Australian australian JJ cord-325712-9kbnyqt3 375 62 bat bat NN cord-325712-9kbnyqt3 375 63 lyssavirus lyssavirus NN cord-325712-9kbnyqt3 375 64 G g NN cord-325712-9kbnyqt3 375 65 envelope envelope NN cord-325712-9kbnyqt3 375 66 glycoprotein glycoprotein NN cord-325712-9kbnyqt3 375 67 occurs occur VBZ cord-325712-9kbnyqt3 375 68 through through IN cord-325712-9kbnyqt3 375 69 a a DT cord-325712-9kbnyqt3 375 70 clathrin clathrin NN cord-325712-9kbnyqt3 375 71 - - HYPH cord-325712-9kbnyqt3 375 72 mediated mediate VBN cord-325712-9kbnyqt3 375 73 endocytic endocytic JJ cord-325712-9kbnyqt3 375 74 pathway pathway NN cord-325712-9kbnyqt3 375 75 that that WDT cord-325712-9kbnyqt3 375 76 requires require VBZ cord-325712-9kbnyqt3 375 77 actin actin NN cord-325712-9kbnyqt3 375 78 and and CC cord-325712-9kbnyqt3 375 79 Rab5 Rab5 NNP cord-325712-9kbnyqt3 375 80 Single single JJ cord-325712-9kbnyqt3 375 81 - - HYPH cord-325712-9kbnyqt3 375 82 particle particle NN cord-325712-9kbnyqt3 375 83 tracking tracking NN cord-325712-9kbnyqt3 375 84 of of IN cord-325712-9kbnyqt3 375 85 human human JJ cord-325712-9kbnyqt3 375 86 immunodeficiency immunodeficiency NN cord-325712-9kbnyqt3 375 87 virus virus NN cord-325712-9kbnyqt3 375 88 type type NN cord-325712-9kbnyqt3 375 89 1 1 CD cord-325712-9kbnyqt3 375 90 productive productive JJ cord-325712-9kbnyqt3 375 91 entry entry NN cord-325712-9kbnyqt3 375 92 into into IN cord-325712-9kbnyqt3 375 93 human human JJ cord-325712-9kbnyqt3 375 94 primary primary JJ cord-325712-9kbnyqt3 375 95 macrophages macrophage NNS cord-325712-9kbnyqt3 375 96 Clathrin Clathrin NNP cord-325712-9kbnyqt3 375 97 - - HYPH cord-325712-9kbnyqt3 375 98 mediated mediate VBN cord-325712-9kbnyqt3 375 99 endocytosis endocytosis NN cord-325712-9kbnyqt3 375 100 in in IN cord-325712-9kbnyqt3 375 101 living live VBG cord-325712-9kbnyqt3 375 102 host host NN cord-325712-9kbnyqt3 375 103 cells cell NNS cord-325712-9kbnyqt3 375 104 visualized visualize VBN cord-325712-9kbnyqt3 375 105 through through IN cord-325712-9kbnyqt3 375 106 quantum quantum NN cord-325712-9kbnyqt3 375 107 dot dot NN cord-325712-9kbnyqt3 375 108 labeling labeling NN cord-325712-9kbnyqt3 375 109 of of IN cord-325712-9kbnyqt3 375 110 infectious infectious JJ cord-325712-9kbnyqt3 375 111 hematopoietic hematopoietic JJ cord-325712-9kbnyqt3 375 112 necrosis necrosis NN cord-325712-9kbnyqt3 375 113 virus virus NN cord-325712-9kbnyqt3 375 114 Mouse Mouse NNP cord-325712-9kbnyqt3 375 115 polyomavirus polyomavirus NNP cord-325712-9kbnyqt3 375 116 enters enter VBZ cord-325712-9kbnyqt3 375 117 early early JJ cord-325712-9kbnyqt3 375 118 endosomes endosome NNS cord-325712-9kbnyqt3 375 119 , , , cord-325712-9kbnyqt3 375 120 requires require VBZ cord-325712-9kbnyqt3 375 121 their -PRON- PRP$ cord-325712-9kbnyqt3 375 122 acidic acidic JJ cord-325712-9kbnyqt3 375 123 pH ph NN cord-325712-9kbnyqt3 375 124 for for IN cord-325712-9kbnyqt3 375 125 productive productive JJ cord-325712-9kbnyqt3 375 126 infection infection NN cord-325712-9kbnyqt3 375 127 , , , cord-325712-9kbnyqt3 375 128 and and CC cord-325712-9kbnyqt3 375 129 meets meet VBZ cord-325712-9kbnyqt3 375 130 transferrin transferrin NN cord-325712-9kbnyqt3 375 131 cargo cargo NN cord-325712-9kbnyqt3 375 132 in in IN cord-325712-9kbnyqt3 375 133 Rab11-positive rab11-positive JJ cord-325712-9kbnyqt3 375 134 endosomes endosome NNS cord-325712-9kbnyqt3 375 135 Drifting drift VBG cord-325712-9kbnyqt3 375 136 motions motion NNS cord-325712-9kbnyqt3 375 137 of of IN cord-325712-9kbnyqt3 375 138 the the DT cord-325712-9kbnyqt3 375 139 adenovirus adenovirus NN cord-325712-9kbnyqt3 375 140 receptor receptor NN cord-325712-9kbnyqt3 375 141 CAR car NN cord-325712-9kbnyqt3 375 142 and and CC cord-325712-9kbnyqt3 375 143 immobile immobile JJ cord-325712-9kbnyqt3 375 144 integrins integrin NNS cord-325712-9kbnyqt3 375 145 initiate initiate VBP cord-325712-9kbnyqt3 375 146 virus virus NN cord-325712-9kbnyqt3 375 147 uncoating uncoating NN cord-325712-9kbnyqt3 375 148 and and CC cord-325712-9kbnyqt3 375 149 membrane membrane NN cord-325712-9kbnyqt3 375 150 lytic lytic JJ cord-325712-9kbnyqt3 375 151 protein protein NN cord-325712-9kbnyqt3 375 152 exposure exposure NN cord-325712-9kbnyqt3 375 153 Co co NN cord-325712-9kbnyqt3 375 154 - - NN cord-325712-9kbnyqt3 375 155 option option NN cord-325712-9kbnyqt3 375 156 of of IN cord-325712-9kbnyqt3 375 157 membrane membrane NN cord-325712-9kbnyqt3 375 158 wounding wounding NN cord-325712-9kbnyqt3 375 159 enables enable VBZ cord-325712-9kbnyqt3 375 160 virus virus NN cord-325712-9kbnyqt3 375 161 penetration penetration NN cord-325712-9kbnyqt3 375 162 into into IN cord-325712-9kbnyqt3 375 163 cells cell NNS cord-325712-9kbnyqt3 375 164 Adenovirus Adenovirus NNP cord-325712-9kbnyqt3 375 165 triggers trigger VBZ cord-325712-9kbnyqt3 375 166 macropinocytosis macropinocytosis NNP cord-325712-9kbnyqt3 375 167 and and CC cord-325712-9kbnyqt3 375 168 endosomal endosomal NNP cord-325712-9kbnyqt3 375 169 leakage leakage VB cord-325712-9kbnyqt3 375 170 together together RB cord-325712-9kbnyqt3 375 171 with with IN cord-325712-9kbnyqt3 375 172 its -PRON- PRP$ cord-325712-9kbnyqt3 375 173 clathrin clathrin NN cord-325712-9kbnyqt3 375 174 - - HYPH cord-325712-9kbnyqt3 375 175 mediated mediate VBN cord-325712-9kbnyqt3 375 176 uptake uptake NN cord-325712-9kbnyqt3 376 1 The the DT cord-325712-9kbnyqt3 376 2 first first JJ cord-325712-9kbnyqt3 376 3 step step NN cord-325712-9kbnyqt3 376 4 of of IN cord-325712-9kbnyqt3 376 5 adenovirus adenovirus NN cord-325712-9kbnyqt3 376 6 type type NN cord-325712-9kbnyqt3 376 7 2 2 CD cord-325712-9kbnyqt3 376 8 disassembly disassembly NN cord-325712-9kbnyqt3 376 9 occurs occur VBZ cord-325712-9kbnyqt3 376 10 at at IN cord-325712-9kbnyqt3 376 11 the the DT cord-325712-9kbnyqt3 376 12 cell cell NN cord-325712-9kbnyqt3 376 13 surface surface NN cord-325712-9kbnyqt3 376 14 , , , cord-325712-9kbnyqt3 376 15 independently independently RB cord-325712-9kbnyqt3 376 16 of of IN cord-325712-9kbnyqt3 376 17 endocytosis endocytosis NN cord-325712-9kbnyqt3 376 18 and and CC cord-325712-9kbnyqt3 376 19 escape escape VB cord-325712-9kbnyqt3 376 20 to to IN cord-325712-9kbnyqt3 376 21 the the DT cord-325712-9kbnyqt3 376 22 cytosol cytosol NN cord-325712-9kbnyqt3 376 23 Clathrin Clathrin NNP cord-325712-9kbnyqt3 376 24 - - HYPH cord-325712-9kbnyqt3 376 25 and and CC cord-325712-9kbnyqt3 376 26 caveolin-1-independent caveolin-1-independent NNP cord-325712-9kbnyqt3 376 27 endocytosis endocytosis NN cord-325712-9kbnyqt3 376 28 Ligands Ligands NNPS cord-325712-9kbnyqt3 376 29 for for IN cord-325712-9kbnyqt3 376 30 clathrin clathrin NN cord-325712-9kbnyqt3 376 31 - - HYPH cord-325712-9kbnyqt3 376 32 mediated mediate VBN cord-325712-9kbnyqt3 376 33 endocytosis endocytosis NN cord-325712-9kbnyqt3 376 34 are be VBP cord-325712-9kbnyqt3 376 35 differentially differentially RB cord-325712-9kbnyqt3 376 36 sorted sort VBN cord-325712-9kbnyqt3 376 37 into into IN cord-325712-9kbnyqt3 376 38 distinct distinct JJ cord-325712-9kbnyqt3 376 39 populations population NNS cord-325712-9kbnyqt3 376 40 of of IN cord-325712-9kbnyqt3 376 41 early early JJ cord-325712-9kbnyqt3 376 42 endosomes endosome NNS cord-325712-9kbnyqt3 377 1 The the DT cord-325712-9kbnyqt3 377 2 human human JJ cord-325712-9kbnyqt3 377 3 polyomavirus polyomavirus NN cord-325712-9kbnyqt3 377 4 , , , cord-325712-9kbnyqt3 377 5 JCV JCV NNP cord-325712-9kbnyqt3 377 6 , , , cord-325712-9kbnyqt3 377 7 uses use VBZ cord-325712-9kbnyqt3 377 8 serotonin serotonin NN cord-325712-9kbnyqt3 377 9 receptors receptor NNS cord-325712-9kbnyqt3 377 10 to to TO cord-325712-9kbnyqt3 377 11 infect infect VB cord-325712-9kbnyqt3 377 12 cells cell NNS cord-325712-9kbnyqt3 377 13 Actin Actin NNP cord-325712-9kbnyqt3 377 14 - - HYPH cord-325712-9kbnyqt3 377 15 dependent dependent JJ cord-325712-9kbnyqt3 377 16 receptor receptor NN cord-325712-9kbnyqt3 377 17 colocalization colocalization NN cord-325712-9kbnyqt3 377 18 required require VBN cord-325712-9kbnyqt3 377 19 for for IN cord-325712-9kbnyqt3 377 20 human human JJ cord-325712-9kbnyqt3 377 21 immunodeficiency immunodeficiency NN cord-325712-9kbnyqt3 377 22 virus virus NN cord-325712-9kbnyqt3 377 23 entry entry NN cord-325712-9kbnyqt3 377 24 into into IN cord-325712-9kbnyqt3 377 25 host host NN cord-325712-9kbnyqt3 377 26 cells cell NNS cord-325712-9kbnyqt3 377 27 Role role NN cord-325712-9kbnyqt3 377 28 of of IN cord-325712-9kbnyqt3 377 29 protein protein NN cord-325712-9kbnyqt3 377 30 kinase kinase NN cord-325712-9kbnyqt3 377 31 C C NNP cord-325712-9kbnyqt3 377 32 betaII betaII NNP cord-325712-9kbnyqt3 377 33 in in IN cord-325712-9kbnyqt3 377 34 influenza influenza NN cord-325712-9kbnyqt3 377 35 virus virus NN cord-325712-9kbnyqt3 377 36 entry entry NN cord-325712-9kbnyqt3 377 37 via via IN cord-325712-9kbnyqt3 377 38 late late JJ cord-325712-9kbnyqt3 377 39 endosomes endosome NNS cord-325712-9kbnyqt3 377 40 Cellular cellular JJ cord-325712-9kbnyqt3 377 41 and and CC cord-325712-9kbnyqt3 377 42 viral viral JJ cord-325712-9kbnyqt3 377 43 requirements requirement NNS cord-325712-9kbnyqt3 377 44 for for IN cord-325712-9kbnyqt3 377 45 rapid rapid JJ cord-325712-9kbnyqt3 377 46 endocytic endocytic JJ cord-325712-9kbnyqt3 377 47 entry entry NN cord-325712-9kbnyqt3 377 48 of of IN cord-325712-9kbnyqt3 377 49 herpes herpes NN cord-325712-9kbnyqt3 377 50 simplex simplex NN cord-325712-9kbnyqt3 377 51 virus virus NN cord-325712-9kbnyqt3 377 52 Rab7 Rab7 NNP cord-325712-9kbnyqt3 377 53 associates associate NNS cord-325712-9kbnyqt3 377 54 with with IN cord-325712-9kbnyqt3 377 55 early early JJ cord-325712-9kbnyqt3 377 56 endosomes endosome NNS cord-325712-9kbnyqt3 377 57 to to TO cord-325712-9kbnyqt3 377 58 mediate mediate VB cord-325712-9kbnyqt3 377 59 sorting sorting NN cord-325712-9kbnyqt3 377 60 and and CC cord-325712-9kbnyqt3 377 61 transport transport NN cord-325712-9kbnyqt3 377 62 of of IN cord-325712-9kbnyqt3 377 63 semliki semliki NNP cord-325712-9kbnyqt3 377 64 forest forest NNP cord-325712-9kbnyqt3 377 65 virus virus NN cord-325712-9kbnyqt3 377 66 to to IN cord-325712-9kbnyqt3 377 67 late late JJ cord-325712-9kbnyqt3 377 68 endosomes endosome NNS cord-325712-9kbnyqt3 377 69 Detection detection NN cord-325712-9kbnyqt3 377 70 of of IN cord-325712-9kbnyqt3 377 71 individual individual JJ cord-325712-9kbnyqt3 377 72 fluorescently fluorescently RB cord-325712-9kbnyqt3 377 73 labeled label VBN cord-325712-9kbnyqt3 377 74 reovirions reovirion NNS cord-325712-9kbnyqt3 377 75 in in IN cord-325712-9kbnyqt3 377 76 living living NN cord-325712-9kbnyqt3 377 77 cells cell NNS cord-325712-9kbnyqt3 378 1 Cytoplasmic Cytoplasmic NNP cord-325712-9kbnyqt3 378 2 trafficking trafficking NN cord-325712-9kbnyqt3 378 3 , , , cord-325712-9kbnyqt3 378 4 endosomal endosomal NNP cord-325712-9kbnyqt3 378 5 escape escape NN cord-325712-9kbnyqt3 378 6 , , , cord-325712-9kbnyqt3 378 7 and and CC cord-325712-9kbnyqt3 378 8 perinuclear perinuclear NNP cord-325712-9kbnyqt3 378 9 accumulation accumulation NN cord-325712-9kbnyqt3 378 10 of of IN cord-325712-9kbnyqt3 378 11 adeno adeno NN cord-325712-9kbnyqt3 378 12 - - HYPH cord-325712-9kbnyqt3 378 13 associated associate VBN cord-325712-9kbnyqt3 378 14 virus virus NN cord-325712-9kbnyqt3 378 15 type type NN cord-325712-9kbnyqt3 378 16 2 2 CD cord-325712-9kbnyqt3 378 17 particles particle NNS cord-325712-9kbnyqt3 378 18 are be VBP cord-325712-9kbnyqt3 378 19 facilitated facilitate VBN cord-325712-9kbnyqt3 378 20 by by IN cord-325712-9kbnyqt3 378 21 microtubule microtubule NN cord-325712-9kbnyqt3 378 22 network network NN cord-325712-9kbnyqt3 378 23 Quantitative Quantitative NNP cord-325712-9kbnyqt3 378 24 four four CD cord-325712-9kbnyqt3 378 25 - - HYPH cord-325712-9kbnyqt3 378 26 dimensional dimensional JJ cord-325712-9kbnyqt3 378 27 tracking tracking NN cord-325712-9kbnyqt3 378 28 of of IN cord-325712-9kbnyqt3 378 29 cytoplasmic cytoplasmic JJ cord-325712-9kbnyqt3 378 30 and and CC cord-325712-9kbnyqt3 378 31 nuclear nuclear JJ cord-325712-9kbnyqt3 378 32 HIV-1 HIV-1 NNP cord-325712-9kbnyqt3 378 33 complexes complex NNS cord-325712-9kbnyqt3 378 34 Rapid Rapid NNP cord-325712-9kbnyqt3 378 35 actin actin NN cord-325712-9kbnyqt3 378 36 - - HYPH cord-325712-9kbnyqt3 378 37 dependent dependent JJ cord-325712-9kbnyqt3 378 38 viral viral JJ cord-325712-9kbnyqt3 378 39 motility motility NN cord-325712-9kbnyqt3 378 40 in in IN cord-325712-9kbnyqt3 378 41 live live JJ cord-325712-9kbnyqt3 378 42 cells cell NNS cord-325712-9kbnyqt3 378 43 Adenovirus Adenovirus NNP cord-325712-9kbnyqt3 378 44 transport transport NN cord-325712-9kbnyqt3 378 45 via via IN cord-325712-9kbnyqt3 378 46 direct direct JJ cord-325712-9kbnyqt3 378 47 interaction interaction NN cord-325712-9kbnyqt3 378 48 of of IN cord-325712-9kbnyqt3 378 49 cytoplasmic cytoplasmic JJ cord-325712-9kbnyqt3 378 50 dynein dynein NN cord-325712-9kbnyqt3 378 51 with with IN cord-325712-9kbnyqt3 378 52 the the DT cord-325712-9kbnyqt3 378 53 viral viral JJ cord-325712-9kbnyqt3 378 54 capsid capsid NN cord-325712-9kbnyqt3 378 55 hexon hexon NNP cord-325712-9kbnyqt3 378 56 subunit subunit NN cord-325712-9kbnyqt3 378 57 The the DT cord-325712-9kbnyqt3 378 58 nuclear nuclear JJ cord-325712-9kbnyqt3 378 59 export export NN cord-325712-9kbnyqt3 378 60 factor factor NN cord-325712-9kbnyqt3 379 1 CRM1 CRM1 NNP cord-325712-9kbnyqt3 379 2 controls control VBZ cord-325712-9kbnyqt3 379 3 juxta juxta JJ cord-325712-9kbnyqt3 379 4 - - HYPH cord-325712-9kbnyqt3 379 5 nuclear nuclear JJ cord-325712-9kbnyqt3 379 6 microtubule microtubule NN cord-325712-9kbnyqt3 379 7 - - HYPH cord-325712-9kbnyqt3 379 8 dependent dependent JJ cord-325712-9kbnyqt3 379 9 virus virus NN cord-325712-9kbnyqt3 379 10 transport transport VBP cord-325712-9kbnyqt3 379 11 Direct direct JJ cord-325712-9kbnyqt3 379 12 visualization visualization NN cord-325712-9kbnyqt3 379 13 of of IN cord-325712-9kbnyqt3 379 14 HIV-1 HIV-1 NNP cord-325712-9kbnyqt3 379 15 with with IN cord-325712-9kbnyqt3 379 16 correlative correlative JJ cord-325712-9kbnyqt3 379 17 live live JJ cord-325712-9kbnyqt3 379 18 - - HYPH cord-325712-9kbnyqt3 379 19 cell cell NN cord-325712-9kbnyqt3 379 20 microscopy microscopy NN cord-325712-9kbnyqt3 379 21 and and CC cord-325712-9kbnyqt3 379 22 cryo cryo NN cord-325712-9kbnyqt3 379 23 - - HYPH cord-325712-9kbnyqt3 379 24 electron electron NN cord-325712-9kbnyqt3 380 1 tomography tomography NNP cord-325712-9kbnyqt3 380 2 Cytoplasmic Cytoplasmic NNP cord-325712-9kbnyqt3 380 3 HIV-1 HIV-1 NNP cord-325712-9kbnyqt3 380 4 RNA RNA NNP cord-325712-9kbnyqt3 380 5 is be VBZ cord-325712-9kbnyqt3 380 6 mainly mainly RB cord-325712-9kbnyqt3 380 7 transported transport VBN cord-325712-9kbnyqt3 380 8 by by IN cord-325712-9kbnyqt3 380 9 diffusion diffusion NN cord-325712-9kbnyqt3 380 10 in in IN cord-325712-9kbnyqt3 380 11 the the DT cord-325712-9kbnyqt3 380 12 presence presence NN cord-325712-9kbnyqt3 380 13 or or CC cord-325712-9kbnyqt3 380 14 absence absence NN cord-325712-9kbnyqt3 380 15 of of IN cord-325712-9kbnyqt3 380 16 gag gag NN cord-325712-9kbnyqt3 380 17 protein protein NN cord-325712-9kbnyqt3 380 18 HIV-1 HIV-1 NNP cord-325712-9kbnyqt3 380 19 pre pre JJ cord-325712-9kbnyqt3 380 20 - - JJ cord-325712-9kbnyqt3 380 21 integration integration JJ cord-325712-9kbnyqt3 380 22 complexes complex NNS cord-325712-9kbnyqt3 381 1 selectively selectively RB cord-325712-9kbnyqt3 381 2 target target VB cord-325712-9kbnyqt3 381 3 decondensed decondense VBN cord-325712-9kbnyqt3 381 4 chromatin chromatin NN cord-325712-9kbnyqt3 381 5 in in IN cord-325712-9kbnyqt3 381 6 the the DT cord-325712-9kbnyqt3 381 7 nuclear nuclear JJ cord-325712-9kbnyqt3 381 8 periphery periphery NN cord-325712-9kbnyqt3 381 9 Using use VBG cord-325712-9kbnyqt3 381 10 single single JJ cord-325712-9kbnyqt3 381 11 - - HYPH cord-325712-9kbnyqt3 381 12 particle particle NN cord-325712-9kbnyqt3 381 13 tracking tracking NN cord-325712-9kbnyqt3 381 14 to to TO cord-325712-9kbnyqt3 381 15 study study VB cord-325712-9kbnyqt3 381 16 nuclear nuclear JJ cord-325712-9kbnyqt3 381 17 trafficking trafficking NN cord-325712-9kbnyqt3 381 18 of of IN cord-325712-9kbnyqt3 381 19 viral viral JJ cord-325712-9kbnyqt3 381 20 genes gene NNS cord-325712-9kbnyqt3 382 1 The the DT cord-325712-9kbnyqt3 382 2 Herpesvirus Herpesvirus NNP cord-325712-9kbnyqt3 382 3 capsid capsid NN cord-325712-9kbnyqt3 382 4 surface surface NN cord-325712-9kbnyqt3 382 5 protein protein NN cord-325712-9kbnyqt3 382 6 , , , cord-325712-9kbnyqt3 382 7 VP26 VP26 NNP cord-325712-9kbnyqt3 382 8 , , , cord-325712-9kbnyqt3 382 9 and and CC cord-325712-9kbnyqt3 382 10 the the DT cord-325712-9kbnyqt3 382 11 majority majority NN cord-325712-9kbnyqt3 382 12 of of IN cord-325712-9kbnyqt3 382 13 the the DT cord-325712-9kbnyqt3 382 14 tegument tegument NN cord-325712-9kbnyqt3 382 15 proteins protein NNS cord-325712-9kbnyqt3 382 16 are be VBP cord-325712-9kbnyqt3 382 17 dispensable dispensable JJ cord-325712-9kbnyqt3 382 18 for for IN cord-325712-9kbnyqt3 382 19 capsid capsid JJ cord-325712-9kbnyqt3 382 20 transport transport NN cord-325712-9kbnyqt3 382 21 toward toward IN cord-325712-9kbnyqt3 382 22 the the DT cord-325712-9kbnyqt3 382 23 nucleus nucleus NN cord-325712-9kbnyqt3 382 24 Targeting target VBG cord-325712-9kbnyqt3 382 25 of of IN cord-325712-9kbnyqt3 382 26 herpesvirus herpesvirus NN cord-325712-9kbnyqt3 382 27 capsid capsid NN cord-325712-9kbnyqt3 382 28 transport transport NN cord-325712-9kbnyqt3 382 29 in in IN cord-325712-9kbnyqt3 382 30 axons axon NNS cord-325712-9kbnyqt3 382 31 is be VBZ cord-325712-9kbnyqt3 382 32 coupled couple VBN cord-325712-9kbnyqt3 382 33 to to IN cord-325712-9kbnyqt3 382 34 association association NN cord-325712-9kbnyqt3 382 35 with with IN cord-325712-9kbnyqt3 382 36 specific specific JJ cord-325712-9kbnyqt3 382 37 sets set NNS cord-325712-9kbnyqt3 382 38 of of IN cord-325712-9kbnyqt3 382 39 tegument tegument NN cord-325712-9kbnyqt3 382 40 proteins protein NNS cord-325712-9kbnyqt3 383 1 The the DT cord-325712-9kbnyqt3 383 2 inner inner JJ cord-325712-9kbnyqt3 383 3 tegument tegument NN cord-325712-9kbnyqt3 383 4 promotes promote VBZ cord-325712-9kbnyqt3 383 5 herpes herpes NNP cord-325712-9kbnyqt3 383 6 simplex simplex NNP cord-325712-9kbnyqt3 383 7 virus virus NN cord-325712-9kbnyqt3 383 8 capsid capsid NN cord-325712-9kbnyqt3 383 9 motility motility NN cord-325712-9kbnyqt3 383 10 along along IN cord-325712-9kbnyqt3 383 11 microtubules microtubule NNS cord-325712-9kbnyqt3 383 12 in in IN cord-325712-9kbnyqt3 383 13 vitro vitro FW cord-325712-9kbnyqt3 383 14 Eclipse Eclipse NNP cord-325712-9kbnyqt3 383 15 phase phase NN cord-325712-9kbnyqt3 383 16 of of IN cord-325712-9kbnyqt3 383 17 herpes herpes NN cord-325712-9kbnyqt3 383 18 simplex simplex NNP cord-325712-9kbnyqt3 383 19 virus virus NN cord-325712-9kbnyqt3 383 20 type type NN cord-325712-9kbnyqt3 383 21 1 1 CD cord-325712-9kbnyqt3 383 22 infection infection NN cord-325712-9kbnyqt3 383 23 : : : cord-325712-9kbnyqt3 383 24 efficient efficient JJ cord-325712-9kbnyqt3 383 25 dynein dynein NN cord-325712-9kbnyqt3 383 26 - - HYPH cord-325712-9kbnyqt3 383 27 mediated mediate VBN cord-325712-9kbnyqt3 383 28 capsid capsid NN cord-325712-9kbnyqt3 383 29 transport transport NN cord-325712-9kbnyqt3 383 30 without without IN cord-325712-9kbnyqt3 383 31 the the DT cord-325712-9kbnyqt3 383 32 small small JJ cord-325712-9kbnyqt3 383 33 capsid capsid NN cord-325712-9kbnyqt3 383 34 protein protein NN cord-325712-9kbnyqt3 384 1 VP26 VP26 NNP cord-325712-9kbnyqt3 384 2 Nuclear Nuclear NNP cord-325712-9kbnyqt3 384 3 targeting targeting NN cord-325712-9kbnyqt3 384 4 of of IN cord-325712-9kbnyqt3 384 5 adenovirus adenovirus NN cord-325712-9kbnyqt3 384 6 type type NN cord-325712-9kbnyqt3 384 7 2 2 CD cord-325712-9kbnyqt3 384 8 requires require VBZ cord-325712-9kbnyqt3 384 9 CRM1-mediated CRM1-mediated NNP cord-325712-9kbnyqt3 384 10 nuclear nuclear JJ cord-325712-9kbnyqt3 384 11 export export NN cord-325712-9kbnyqt3 384 12 HIV HIV NNP cord-325712-9kbnyqt3 384 13 enters enter VBZ cord-325712-9kbnyqt3 384 14 cells cell NNS cord-325712-9kbnyqt3 384 15 via via IN cord-325712-9kbnyqt3 384 16 endocytosis endocytosis NN cord-325712-9kbnyqt3 384 17 and and CC cord-325712-9kbnyqt3 384 18 dynamindependent dynamindependent JJ cord-325712-9kbnyqt3 384 19 fusion fusion NN cord-325712-9kbnyqt3 384 20 with with IN cord-325712-9kbnyqt3 384 21 endosomes endosome NNS cord-325712-9kbnyqt3 384 22 Time time NN cord-325712-9kbnyqt3 384 23 - - HYPH cord-325712-9kbnyqt3 384 24 resolved resolve VBN cord-325712-9kbnyqt3 384 25 imaging imaging NN cord-325712-9kbnyqt3 384 26 of of IN cord-325712-9kbnyqt3 384 27 HIV-1 HIV-1 NNP cord-325712-9kbnyqt3 384 28 Env Env NNP cord-325712-9kbnyqt3 384 29 - - HYPH cord-325712-9kbnyqt3 384 30 mediated mediate VBN cord-325712-9kbnyqt3 384 31 lipid lipid NN cord-325712-9kbnyqt3 384 32 and and CC cord-325712-9kbnyqt3 384 33 content content NN cord-325712-9kbnyqt3 384 34 mixing mixing NN cord-325712-9kbnyqt3 384 35 between between IN cord-325712-9kbnyqt3 384 36 a a DT cord-325712-9kbnyqt3 384 37 single single JJ cord-325712-9kbnyqt3 384 38 virion virion NN cord-325712-9kbnyqt3 384 39 and and CC cord-325712-9kbnyqt3 384 40 cell cell NN cord-325712-9kbnyqt3 384 41 membrane membrane NN cord-325712-9kbnyqt3 384 42 Imaging Imaging NNP cord-325712-9kbnyqt3 384 43 individual individual JJ cord-325712-9kbnyqt3 384 44 retroviral retroviral NN cord-325712-9kbnyqt3 384 45 fusion fusion NN cord-325712-9kbnyqt3 384 46 events event NNS cord-325712-9kbnyqt3 384 47 : : : cord-325712-9kbnyqt3 384 48 from from IN cord-325712-9kbnyqt3 384 49 hemifusion hemifusion NN cord-325712-9kbnyqt3 384 50 to to TO cord-325712-9kbnyqt3 384 51 pore pore VB cord-325712-9kbnyqt3 384 52 formation formation NN cord-325712-9kbnyqt3 384 53 and and CC cord-325712-9kbnyqt3 384 54 growth growth NN cord-325712-9kbnyqt3 385 1 Imaging image VBG cord-325712-9kbnyqt3 385 2 single single JJ cord-325712-9kbnyqt3 385 3 retrovirus retrovirus NN cord-325712-9kbnyqt3 385 4 entry entry NN cord-325712-9kbnyqt3 385 5 through through IN cord-325712-9kbnyqt3 385 6 alternative alternative JJ cord-325712-9kbnyqt3 385 7 receptor receptor NN cord-325712-9kbnyqt3 385 8 isoforms isoform NNS cord-325712-9kbnyqt3 385 9 and and CC cord-325712-9kbnyqt3 385 10 intermediates intermediate NNS cord-325712-9kbnyqt3 385 11 of of IN cord-325712-9kbnyqt3 385 12 virus virus NN cord-325712-9kbnyqt3 385 13 - - HYPH cord-325712-9kbnyqt3 385 14 endosome endosome NN cord-325712-9kbnyqt3 385 15 fusion fusion NN cord-325712-9kbnyqt3 385 16 Synchronized synchronize VBN cord-325712-9kbnyqt3 385 17 retrovirus retrovirus NN cord-325712-9kbnyqt3 385 18 fusion fusion NN cord-325712-9kbnyqt3 385 19 in in IN cord-325712-9kbnyqt3 385 20 cells cell NNS cord-325712-9kbnyqt3 385 21 expressing express VBG cord-325712-9kbnyqt3 385 22 alternative alternative JJ cord-325712-9kbnyqt3 385 23 receptor receptor NN cord-325712-9kbnyqt3 385 24 isoforms isoform NNS cord-325712-9kbnyqt3 385 25 releases release VBZ cord-325712-9kbnyqt3 385 26 the the DT cord-325712-9kbnyqt3 385 27 viral viral JJ cord-325712-9kbnyqt3 385 28 core core NN cord-325712-9kbnyqt3 385 29 into into IN cord-325712-9kbnyqt3 385 30 distinct distinct JJ cord-325712-9kbnyqt3 385 31 sub sub JJ cord-325712-9kbnyqt3 385 32 - - JJ cord-325712-9kbnyqt3 385 33 cellular cellular JJ cord-325712-9kbnyqt3 385 34 compartments compartment NNS cord-325712-9kbnyqt3 386 1 Endosome Endosome NNP cord-325712-9kbnyqt3 386 2 - - HYPH cord-325712-9kbnyqt3 386 3 to to IN cord-325712-9kbnyqt3 386 4 - - HYPH cord-325712-9kbnyqt3 386 5 cytosol cytosol NN cord-325712-9kbnyqt3 386 6 transport transport NN cord-325712-9kbnyqt3 386 7 of of IN cord-325712-9kbnyqt3 386 8 viral viral JJ cord-325712-9kbnyqt3 386 9 nucleocapsids nucleocapsid NNS cord-325712-9kbnyqt3 386 10 Mechanisms Mechanisms NNPS cord-325712-9kbnyqt3 386 11 of of IN cord-325712-9kbnyqt3 386 12 influenza influenza NN cord-325712-9kbnyqt3 386 13 viral viral JJ cord-325712-9kbnyqt3 386 14 membrane membrane NN cord-325712-9kbnyqt3 386 15 fusion fusion NN cord-325712-9kbnyqt3 386 16 Statistical statistical JJ cord-325712-9kbnyqt3 386 17 mechanics mechanic NNS cord-325712-9kbnyqt3 386 18 of of IN cord-325712-9kbnyqt3 386 19 viral viral JJ cord-325712-9kbnyqt3 386 20 entry entry NN cord-325712-9kbnyqt3 386 21 Chikungunya Chikungunya NNP cord-325712-9kbnyqt3 386 22 virus virus NN cord-325712-9kbnyqt3 386 23 fusion fusion NN cord-325712-9kbnyqt3 386 24 properties property NNS cord-325712-9kbnyqt3 386 25 elucidated elucidate VBN cord-325712-9kbnyqt3 386 26 by by IN cord-325712-9kbnyqt3 386 27 single single JJ cord-325712-9kbnyqt3 386 28 - - HYPH cord-325712-9kbnyqt3 386 29 particle particle NN cord-325712-9kbnyqt3 386 30 and and CC cord-325712-9kbnyqt3 386 31 bulk bulk NN cord-325712-9kbnyqt3 386 32 approaches approach NNS cord-325712-9kbnyqt3 386 33 Sequential sequential JJ cord-325712-9kbnyqt3 386 34 conformational conformational JJ cord-325712-9kbnyqt3 386 35 rearrangements rearrangement NNS cord-325712-9kbnyqt3 386 36 in in IN cord-325712-9kbnyqt3 386 37 flavivirus flavivirus JJ cord-325712-9kbnyqt3 386 38 membrane membrane NN cord-325712-9kbnyqt3 386 39 fusion fusion NN cord-325712-9kbnyqt3 386 40 Mechanism Mechanism NNP cord-325712-9kbnyqt3 386 41 of of IN cord-325712-9kbnyqt3 386 42 membrane membrane NN cord-325712-9kbnyqt3 386 43 fusion fusion NN cord-325712-9kbnyqt3 386 44 induced induce VBN cord-325712-9kbnyqt3 386 45 by by IN cord-325712-9kbnyqt3 386 46 vesicular vesicular JJ cord-325712-9kbnyqt3 386 47 stomatitis stomatitis NN cord-325712-9kbnyqt3 386 48 virus virus NN cord-325712-9kbnyqt3 386 49 G g NN cord-325712-9kbnyqt3 386 50 protein protein NN cord-325712-9kbnyqt3 386 51 Variations variation NNS cord-325712-9kbnyqt3 386 52 in in IN cord-325712-9kbnyqt3 386 53 pH ph NN cord-325712-9kbnyqt3 386 54 sensitivity sensitivity NN cord-325712-9kbnyqt3 386 55 , , , cord-325712-9kbnyqt3 386 56 acid acid NN cord-325712-9kbnyqt3 386 57 stability stability NN cord-325712-9kbnyqt3 386 58 , , , cord-325712-9kbnyqt3 386 59 and and CC cord-325712-9kbnyqt3 386 60 fusogenicity fusogenicity NN cord-325712-9kbnyqt3 386 61 of of IN cord-325712-9kbnyqt3 386 62 three three CD cord-325712-9kbnyqt3 386 63 influenza influenza NN cord-325712-9kbnyqt3 386 64 virus virus NN cord-325712-9kbnyqt3 386 65 H3 H3 NNP cord-325712-9kbnyqt3 386 66 subtypes subtype NNS cord-325712-9kbnyqt3 386 67 Influenza influenza NN cord-325712-9kbnyqt3 386 68 - - HYPH cord-325712-9kbnyqt3 386 69 virus virus NN cord-325712-9kbnyqt3 386 70 membrane membrane NN cord-325712-9kbnyqt3 386 71 fusion fusion NN cord-325712-9kbnyqt3 386 72 by by IN cord-325712-9kbnyqt3 386 73 cooperative cooperative JJ cord-325712-9kbnyqt3 386 74 fold fold NN cord-325712-9kbnyqt3 386 75 - - HYPH cord-325712-9kbnyqt3 386 76 back back NN cord-325712-9kbnyqt3 386 77 of of IN cord-325712-9kbnyqt3 386 78 stochastically stochastically RB cord-325712-9kbnyqt3 386 79 induced induce VBN cord-325712-9kbnyqt3 386 80 hemagglutinin hemagglutinin NN cord-325712-9kbnyqt3 386 81 intermediates intermediate NNS cord-325712-9kbnyqt3 386 82 Distinct distinct JJ cord-325712-9kbnyqt3 386 83 functional functional JJ cord-325712-9kbnyqt3 386 84 determinants determinant NNS cord-325712-9kbnyqt3 386 85 of of IN cord-325712-9kbnyqt3 386 86 influenza influenza NN cord-325712-9kbnyqt3 386 87 hemagglutininmediated hemagglutininmediate VBN cord-325712-9kbnyqt3 386 88 membrane membrane NN cord-325712-9kbnyqt3 386 89 fusion fusion NN cord-325712-9kbnyqt3 386 90 . . . cord-325712-9kbnyqt3 387 1 elife elife NNP cord-325712-9kbnyqt3 387 2 4 4 CD cord-325712-9kbnyqt3 387 3 : : : cord-325712-9kbnyqt3 388 1 e11009 e11009 NNP cord-325712-9kbnyqt3 388 2 Stochastic stochastic JJ cord-325712-9kbnyqt3 388 3 fusion fusion NN cord-325712-9kbnyqt3 388 4 simulations simulation NNS cord-325712-9kbnyqt3 388 5 and and CC cord-325712-9kbnyqt3 388 6 experiments experiment NNS cord-325712-9kbnyqt3 388 7 suggest suggest VBP cord-325712-9kbnyqt3 388 8 passive passive JJ cord-325712-9kbnyqt3 388 9 and and CC cord-325712-9kbnyqt3 388 10 active active JJ cord-325712-9kbnyqt3 388 11 roles role NNS cord-325712-9kbnyqt3 388 12 of of IN cord-325712-9kbnyqt3 388 13 hemagglutinin hemagglutinin NN cord-325712-9kbnyqt3 388 14 during during IN cord-325712-9kbnyqt3 388 15 membrane membrane NN cord-325712-9kbnyqt3 388 16 fusion fusion NN cord-325712-9kbnyqt3 388 17 Viral viral JJ cord-325712-9kbnyqt3 388 18 fusion fusion NN cord-325712-9kbnyqt3 388 19 efficacy efficacy NN cord-325712-9kbnyqt3 388 20 of of IN cord-325712-9kbnyqt3 388 21 specific specific JJ cord-325712-9kbnyqt3 388 22 H3N2 H3N2 NNP cord-325712-9kbnyqt3 388 23 influenza influenza NN cord-325712-9kbnyqt3 388 24 virus virus NN cord-325712-9kbnyqt3 388 25 reassortant reassortant JJ cord-325712-9kbnyqt3 388 26 combinations combination NNS cord-325712-9kbnyqt3 388 27 at at IN cord-325712-9kbnyqt3 388 28 single single JJ cord-325712-9kbnyqt3 388 29 - - HYPH cord-325712-9kbnyqt3 388 30 particle particle NN cord-325712-9kbnyqt3 388 31 level level NN cord-325712-9kbnyqt3 388 32 Relating relate VBG cord-325712-9kbnyqt3 388 33 influenza influenza NN cord-325712-9kbnyqt3 388 34 virus virus NN cord-325712-9kbnyqt3 388 35 membrane membrane NN cord-325712-9kbnyqt3 388 36 fusion fusion NN cord-325712-9kbnyqt3 388 37 kinetics kinetic NNS cord-325712-9kbnyqt3 388 38 to to IN cord-325712-9kbnyqt3 388 39 stoichiometry stoichiometry NN cord-325712-9kbnyqt3 388 40 of of IN cord-325712-9kbnyqt3 388 41 neutralizing neutralize VBG cord-325712-9kbnyqt3 388 42 antibodies antibody NNS cord-325712-9kbnyqt3 388 43 at at IN cord-325712-9kbnyqt3 388 44 the the DT cord-325712-9kbnyqt3 388 45 single single JJ cord-325712-9kbnyqt3 388 46 - - HYPH cord-325712-9kbnyqt3 388 47 particle particle NN cord-325712-9kbnyqt3 388 48 level level NN cord-325712-9kbnyqt3 388 49 Cell cell NN cord-325712-9kbnyqt3 388 50 fusion fusion NN cord-325712-9kbnyqt3 388 51 by by IN cord-325712-9kbnyqt3 388 52 Semliki Semliki NNP cord-325712-9kbnyqt3 388 53 forest forest NN cord-325712-9kbnyqt3 388 54 , , , cord-325712-9kbnyqt3 388 55 influenza influenza NN cord-325712-9kbnyqt3 388 56 , , , cord-325712-9kbnyqt3 388 57 and and CC cord-325712-9kbnyqt3 388 58 vesicular vesicular JJ cord-325712-9kbnyqt3 388 59 stomatitis stomatitis NN cord-325712-9kbnyqt3 388 60 viruses virus NNS cord-325712-9kbnyqt3 389 1 A a DT cord-325712-9kbnyqt3 389 2 study study NN cord-325712-9kbnyqt3 389 3 of of IN cord-325712-9kbnyqt3 389 4 low low JJ cord-325712-9kbnyqt3 389 5 pH ph NN cord-325712-9kbnyqt3 389 6 - - HYPH cord-325712-9kbnyqt3 389 7 induced induce VBN cord-325712-9kbnyqt3 389 8 refolding refolding NN cord-325712-9kbnyqt3 389 9 of of IN cord-325712-9kbnyqt3 389 10 Env Env NNP cord-325712-9kbnyqt3 389 11 of of IN cord-325712-9kbnyqt3 389 12 avian avian JJ cord-325712-9kbnyqt3 389 13 sarcoma sarcoma NN cord-325712-9kbnyqt3 389 14 and and CC cord-325712-9kbnyqt3 389 15 leukosis leukosis NN cord-325712-9kbnyqt3 389 16 virus virus NN cord-325712-9kbnyqt3 389 17 into into IN cord-325712-9kbnyqt3 389 18 a a DT cord-325712-9kbnyqt3 389 19 six six CD cord-325712-9kbnyqt3 389 20 - - HYPH cord-325712-9kbnyqt3 389 21 helix helix NN cord-325712-9kbnyqt3 389 22 bundle bundle NN cord-325712-9kbnyqt3 390 1 Low low JJ cord-325712-9kbnyqt3 390 2 pH pH NNP cord-325712-9kbnyqt3 390 3 is be VBZ cord-325712-9kbnyqt3 390 4 required require VBN cord-325712-9kbnyqt3 390 5 for for IN cord-325712-9kbnyqt3 390 6 avian avian JJ cord-325712-9kbnyqt3 390 7 sarcoma sarcoma NN cord-325712-9kbnyqt3 390 8 and and CC cord-325712-9kbnyqt3 390 9 leukosis leukosis NN cord-325712-9kbnyqt3 390 10 virus virus NN cord-325712-9kbnyqt3 390 11 Env Env NNP cord-325712-9kbnyqt3 390 12 - - HYPH cord-325712-9kbnyqt3 390 13 induced induce VBN cord-325712-9kbnyqt3 390 14 hemifusion hemifusion NN cord-325712-9kbnyqt3 390 15 and and CC cord-325712-9kbnyqt3 390 16 fusion fusion NN cord-325712-9kbnyqt3 390 17 pore pore NN cord-325712-9kbnyqt3 390 18 formation formation NN cord-325712-9kbnyqt3 390 19 but but CC cord-325712-9kbnyqt3 390 20 not not RB cord-325712-9kbnyqt3 390 21 for for IN cord-325712-9kbnyqt3 390 22 pore pore NN cord-325712-9kbnyqt3 390 23 growth growth NN cord-325712-9kbnyqt3 390 24 Dilation dilation NN cord-325712-9kbnyqt3 390 25 of of IN cord-325712-9kbnyqt3 390 26 the the DT cord-325712-9kbnyqt3 390 27 influenza influenza NN cord-325712-9kbnyqt3 390 28 hemagglutinin hemagglutinin NNP cord-325712-9kbnyqt3 390 29 fusion fusion NN cord-325712-9kbnyqt3 390 30 pore pore NN cord-325712-9kbnyqt3 390 31 revealed reveal VBN cord-325712-9kbnyqt3 390 32 by by IN cord-325712-9kbnyqt3 390 33 the the DT cord-325712-9kbnyqt3 390 34 kinetics kinetic NNS cord-325712-9kbnyqt3 390 35 of of IN cord-325712-9kbnyqt3 390 36 individual individual JJ cord-325712-9kbnyqt3 390 37 cell cell NN cord-325712-9kbnyqt3 390 38 - - HYPH cord-325712-9kbnyqt3 390 39 cell cell NN cord-325712-9kbnyqt3 390 40 fusion fusion NN cord-325712-9kbnyqt3 390 41 events event NNS cord-325712-9kbnyqt3 390 42 Patch Patch NNP cord-325712-9kbnyqt3 390 43 clamp clamp NN cord-325712-9kbnyqt3 390 44 studies study NNS cord-325712-9kbnyqt3 390 45 of of IN cord-325712-9kbnyqt3 390 46 single single JJ cord-325712-9kbnyqt3 390 47 cell cell NN cord-325712-9kbnyqt3 390 48 - - HYPH cord-325712-9kbnyqt3 390 49 fusion fusion NN cord-325712-9kbnyqt3 390 50 events event NNS cord-325712-9kbnyqt3 390 51 mediated mediate VBN cord-325712-9kbnyqt3 390 52 by by IN cord-325712-9kbnyqt3 390 53 a a DT cord-325712-9kbnyqt3 390 54 viral viral JJ cord-325712-9kbnyqt3 390 55 fusion fusion NN cord-325712-9kbnyqt3 390 56 protein protein NN cord-325712-9kbnyqt3 391 1 The the DT cord-325712-9kbnyqt3 391 2 first first JJ cord-325712-9kbnyqt3 391 3 milliseconds millisecond NNS cord-325712-9kbnyqt3 391 4 of of IN cord-325712-9kbnyqt3 391 5 the the DT cord-325712-9kbnyqt3 391 6 pore pore NN cord-325712-9kbnyqt3 391 7 formed form VBN cord-325712-9kbnyqt3 391 8 by by IN cord-325712-9kbnyqt3 391 9 a a DT cord-325712-9kbnyqt3 391 10 fusogenic fusogenic JJ cord-325712-9kbnyqt3 391 11 viral viral JJ cord-325712-9kbnyqt3 391 12 envelope envelope NN cord-325712-9kbnyqt3 391 13 protein protein NN cord-325712-9kbnyqt3 391 14 during during IN cord-325712-9kbnyqt3 391 15 membrane membrane NN cord-325712-9kbnyqt3 391 16 fusion fusion NN cord-325712-9kbnyqt3 391 17 Methodologies Methodologies NNPS cord-325712-9kbnyqt3 391 18 in in IN cord-325712-9kbnyqt3 391 19 the the DT cord-325712-9kbnyqt3 391 20 study study NN cord-325712-9kbnyqt3 391 21 of of IN cord-325712-9kbnyqt3 391 22 cell cell NN cord-325712-9kbnyqt3 391 23 - - HYPH cord-325712-9kbnyqt3 391 24 cell cell NN cord-325712-9kbnyqt3 391 25 fusion fusion NN cord-325712-9kbnyqt3 391 26 Use use NN cord-325712-9kbnyqt3 391 27 of of IN cord-325712-9kbnyqt3 391 28 resonance resonance NN cord-325712-9kbnyqt3 391 29 energy energy NN cord-325712-9kbnyqt3 391 30 transfer transfer NN cord-325712-9kbnyqt3 391 31 to to TO cord-325712-9kbnyqt3 391 32 monitor monitor VB cord-325712-9kbnyqt3 391 33 membrane membrane NN cord-325712-9kbnyqt3 391 34 fusion fusion NN cord-325712-9kbnyqt3 391 35 Fluorescence fluorescence NN cord-325712-9kbnyqt3 391 36 method method NN cord-325712-9kbnyqt3 391 37 for for IN cord-325712-9kbnyqt3 391 38 measuring measure VBG cord-325712-9kbnyqt3 391 39 the the DT cord-325712-9kbnyqt3 391 40 kinetics kinetic NNS cord-325712-9kbnyqt3 391 41 of of IN cord-325712-9kbnyqt3 391 42 fusion fusion NN cord-325712-9kbnyqt3 391 43 between between IN cord-325712-9kbnyqt3 391 44 biological biological JJ cord-325712-9kbnyqt3 391 45 membranes membrane NNS cord-325712-9kbnyqt3 391 46 A a DT cord-325712-9kbnyqt3 391 47 sensitive sensitive JJ cord-325712-9kbnyqt3 391 48 and and CC cord-325712-9kbnyqt3 391 49 specific specific JJ cord-325712-9kbnyqt3 391 50 enzyme enzyme NN cord-325712-9kbnyqt3 391 51 - - HYPH cord-325712-9kbnyqt3 391 52 based base VBN cord-325712-9kbnyqt3 391 53 assay assay NN cord-325712-9kbnyqt3 391 54 detecting detect VBG cord-325712-9kbnyqt3 391 55 HIV-1 HIV-1 NNP cord-325712-9kbnyqt3 391 56 virion virion NN cord-325712-9kbnyqt3 391 57 fusion fusion NN cord-325712-9kbnyqt3 391 58 in in IN cord-325712-9kbnyqt3 391 59 primary primary JJ cord-325712-9kbnyqt3 391 60 T t NN cord-325712-9kbnyqt3 391 61 lymphocytes lymphocyte NNS cord-325712-9kbnyqt3 391 62 Inhibition inhibition NN cord-325712-9kbnyqt3 391 63 of of IN cord-325712-9kbnyqt3 391 64 HIV-1 HIV-1 NNP cord-325712-9kbnyqt3 391 65 endocytosis endocytosis NN cord-325712-9kbnyqt3 391 66 allows allow VBZ cord-325712-9kbnyqt3 391 67 lipid lipid NN cord-325712-9kbnyqt3 391 68 mixing mix VBG cord-325712-9kbnyqt3 391 69 at at IN cord-325712-9kbnyqt3 391 70 the the DT cord-325712-9kbnyqt3 391 71 plasma plasma NN cord-325712-9kbnyqt3 391 72 membrane membrane NN cord-325712-9kbnyqt3 391 73 , , , cord-325712-9kbnyqt3 391 74 but but CC cord-325712-9kbnyqt3 391 75 not not RB cord-325712-9kbnyqt3 391 76 complete complete JJ cord-325712-9kbnyqt3 391 77 fusion fusion NN cord-325712-9kbnyqt3 391 78 Delay delay NN cord-325712-9kbnyqt3 391 79 time time NN cord-325712-9kbnyqt3 391 80 for for IN cord-325712-9kbnyqt3 391 81 influenza influenza NN cord-325712-9kbnyqt3 391 82 virus virus NN cord-325712-9kbnyqt3 392 1 hemagglutinininduced hemagglutinininduced NNP cord-325712-9kbnyqt3 392 2 membrane membrane NN cord-325712-9kbnyqt3 392 3 fusion fusion NN cord-325712-9kbnyqt3 392 4 depends depend VBZ cord-325712-9kbnyqt3 392 5 on on IN cord-325712-9kbnyqt3 392 6 hemagglutinin hemagglutinin NN cord-325712-9kbnyqt3 392 7 surface surface NN cord-325712-9kbnyqt3 392 8 density density NN cord-325712-9kbnyqt3 392 9 Membrane membrane NN cord-325712-9kbnyqt3 392 10 fusion fusion NN cord-325712-9kbnyqt3 392 11 of of IN cord-325712-9kbnyqt3 392 12 Semliki Semliki NNP cord-325712-9kbnyqt3 392 13 Forest Forest NNP cord-325712-9kbnyqt3 392 14 virus virus NN cord-325712-9kbnyqt3 392 15 requires require VBZ cord-325712-9kbnyqt3 392 16 sphingolipids sphingolipid NNS cord-325712-9kbnyqt3 392 17 in in IN cord-325712-9kbnyqt3 392 18 the the DT cord-325712-9kbnyqt3 392 19 target target NN cord-325712-9kbnyqt3 392 20 membrane membrane NN