id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-007275-emmoeuqd	Cooper, Joanne C.	An Impaired Breeding Phenotype in Mice with a Genetic Deletion of Beta-2 Microglobulin and Diminished MHC Class I Expression: Role in Reproductive Fitness(1)	2007-08-01		.txt	text/plain	4436	243	56	title: An Impaired Breeding Phenotype in Mice with a Genetic Deletion of Beta-2 Microglobulin and Diminished MHC Class I Expression: Role in Reproductive Fitness(1) Beta-2 microglobulin (B2M) plays a pivotal role in the biology of mammals, including its association with major histocompatibility complex (MHC) Class I gene products. Here we report the results of a longitudinal study of the reproductive performance of a genetically modified B2m deficient mouse strain with low MHC Class I expression. In the course of experiments designed to generate mouse embryos for gene transcription studies and immuno-detection of MHC products [50] [51] , we consistently observed an impaired reproductive capacity in the B2m deficient mice. Therefore, a possible mechanism operating in the B2m-deficient mice is the absence of secreted MHC class I products, and thus the absence of mating signals resulting in impaired breeding.	./cache/cord-007275-emmoeuqd.txt	./txt/cord-007275-emmoeuqd.txt