id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-011173-c1i0a92f	Moore, Tamson V.	Improved MHC II epitope prediction — a step towards personalized medicine	2019-12-13		.txt	text/plain	1663	72	44	Whereas the presence and expression of neoantigen proteins can be identified through sequencing of the tumour exome, the neoepitopes presented by MHC II molecules must be either discovered empirically using expensive and time-consuming mass spectrometry (MS) techniques 4 or predicted using software-based estimations of peptide-MHC II binding affinity. The deconvoluted peptidomic datasets were then used to train a prediction algorithm, MixMHC2pred, which returns an MHC II binding score for a given peptide sequence and HLA-D allele. The efficacy of such neoantigen-based immunotherapies will be dependent on the identification of a sufficient number of MHC II-binding peptides to stimulate CD4 + T cell responses. Both MARIA and MixMHC2pred have the potential to make personalized neoantigen-based therapies more accessible to patients, including patients with tumours harbouring fewer mutations, by identifying more MHC II-binding epitopes to which CD4 + T cells can respond within each patient's pool of putative neoantigens.	./cache/cord-011173-c1i0a92f.txt	./txt/cord-011173-c1i0a92f.txt