id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-013093-aa4cf44u	Cassotta, Antonino	Deciphering and predicting CD4(+) T cell immunodominance of influenza virus hemagglutinin	2020-07-09		.txt	text/plain	10936	470	50	The detailed and unbiased characterization of HA-reactive memory and naive CD4 + T cell repertoires, paralleled by a deep analysis of the naturally presented repertoire of MHC-II-binding HA peptides by mass spectrometry (MS)-based immunopeptidomics, allowed us to shed new light on the factors governing CD4 + T cell clonal selection and immunodominance to influenza HA in humans. We then selected a large number of H1-HA-specific T cell clones derived from naive or memory T cells of donor HD1 and determined their functional avidity by measuring the proliferative response to autologous monocytes pulsed with different concentrations of the H1-HA peptides or H1-HA protein, which need processing for presentation on MHC-II molecules.	./cache/cord-013093-aa4cf44u.txt	./txt/cord-013093-aa4cf44u.txt