id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-021693-odfxkfu7	Lim, Dong-Gyun	Molecular Mimicry in Multiple Sclerosis: Role of MHC-Altered Peptide Ligands (MAPL)	2007-05-09		.txt	text/plain	3880	173	41	Data from animal studies in the EAE model established that CD4 + Thl cells specific to myelin antigens can play a central role in the induction and progression of autoimmune demyelinating disease [2, 3] . In examining the immune response to MBP, we found that complementary mutations in an antigenic peptide allow for cross-reactivity of autoreacfive T cell clones that may be related to shifts of the TCR structure itself [11] . The new knowledge obtained from this study was 1) that of highly degenerative recognition of peptides by autoreactive CD4 § T cells, including identification of stimulatory ligands not sharing a single amino acid in corresponding positions with the antigen used to establish the T cell clone and 2) the identification of more potent agonistic peptides than cognate self-peptide. Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein Cross-reactive human autoreactive T-ceU receptor responses to altered peptide ligands presented by different MHC class II molecules	./cache/cord-021693-odfxkfu7.txt	./txt/cord-021693-odfxkfu7.txt