id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-022142-d4yxgv83	David, Ayelet	Polymer-Based DNA Delivery Systems for Cancer Immunotherapy	2016-05-28		.txt	text/plain	7778	367	43	A number of polymer-based nanomedicines have been developed to deliver genes into DCs, primarily by incorporating tumor-specific, antigen-encoding plasmid DNA with polycationic molecules to facilitate DNA loading and intracellular trafficking. Direct in vivo targeting of plasmid DNA to DC surface receptors can induce high transfection efficiency and long-term gene expression, essential for antigen loading onto major histocompatibility complex molecules and stimulation of T-cell responses. This chapter highlights the repertoire of non-viral, nanosized polymeric DNA delivery systems (polyplexes) available to achieve effi cient gene transfer into DCs for immunotherapeutic applications in cancer therapy. With respect to clinical translation, effi cacious non-viral gene delivery into DCs will depend on the combination of intelligent material design, the appropriate tumor specifi c antigen-encoding DNA and immuno-stimulatory molecules to promote DC maturation and activation.	./cache/cord-022142-d4yxgv83.txt	./txt/cord-022142-d4yxgv83.txt