id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-275433-58unu79x	Levine, Beth	Unveiling the roles of autophagy in innate and adaptive immunity	2007		.txt	text/plain	8366	375	34	The process of autophagy may degrade intracellular pathogens, deliver endogenous antigens to MHC-class-II-loading compartments, direct viral nucleic acids to Toll-like receptors and regulate T-cell homeostasis. The class III PI3K vPS34 (also known as PIK3C3) generates phosphatidylinositol-3-phosphate (PtdIns3P) by phosphorylating The cellular events during digestion of self constituents or intracellular pathogens follow three distinct stages: initiation (formation of the phagophore), elongation (growth and closure) and maturation of a double membrane autophagosome into an autolysosome. In principle, autophagy may function in the direct elimination of viruses (as shown in vitro), in the breakdown of host factors required for viral replication or the inhibition of innate immune signalling, and in the promotion of cell survival either by maintaining bioenergetics in virally infected cells or by removing toxic self or viral components. In addition, numerous viruses inhibit the PKR (IFN-inducible doublestranded-RNA-dependent protein kinase) antiviral signalling pathway that is required for the induction of autophagy in virally infected cells or activate the autophagy-inhibitory class I PI3K-AKT-mTOR signalling pathway 63 .	./cache/cord-275433-58unu79x.txt	./txt/cord-275433-58unu79x.txt