id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-285091-2i2v5ecg	Kopitar-Jerala, Nataša	The Role of Cysteine Proteinases and their Inhibitors in the Host-Pathogen Cross Talk	2012-12-17		.txt	text/plain	6213	358	44	showed that inhibitors of cysteine proteinases cystatin C and p41 form of major histocompatibility complex invariant chain did not inhibit cathepsin L and the authors suggested that cystatin F might be the inhibitor that selectively regulated cathepsin L activity in macrophages [69] . Gene targeting studies showed a critical role for the lysosomal cysteine protease cathepsin S in the late stages of Ii degradation in B cells, DCs and macrophages [89] [90] [91] and cathepsin L (V in humans) in thymic cortical epithelium [92] . An additional level of control is achieved by the proteolysis full length TLR7 and TLR9 by endosomal cysteine cathepsins and AEP.TLR9 can bind its ligand CpG DNA, but it cannot trigger activation signals without first being processed by endolysosomal proteases, which remove N-terminal region [98] [99] [100] [101] . The study shows that the functions of proteinases in the virus entry into the cell as well as in host immune response are relevant for the possible therapy with inhibitors.	./cache/cord-285091-2i2v5ecg.txt	./txt/cord-285091-2i2v5ecg.txt