id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-298169-2133gahl	Tamouza, Ryad	Understanding the genetic contribution of the Human Leukocyte Antigen system to common major psychiatric disorders in a world pandemic context	2020-10-05		.txt	text/plain	5938	290	39	Despite evidence of prominent immune implication in a significant subset of major psychiatric disorder patients such as schizophrenia, bipolar disorder or depression (Khandaker, Dantzer, Jones, 2017) or autism spectrum disorder (Meltzer & Van de Water, 2017) , deciphering the mechanistic link between the HLA system and these disorders was difficult, primarily because of the complex genetic architecture of the HLA system. This section reviews investigations of HLA gene candidate association in schizophrenia, bipolar disorders and Autism Spectrum Disorders, focusing on the risk/protection that HLA alleles/haplotypes may confer on specific sub-groups. Influenza and other infections prenatally can also increase risk of schizophrenia and autism spectrum disorders in the offspring, suggesting that HLA/MHC genetic variations may interact with prenatal infection in the etiology of major psychiatric disorders, although complicated by the immune-suppression that occurs in pregnancy (Shah et al, 2010) .	./cache/cord-298169-2133gahl.txt	./txt/cord-298169-2133gahl.txt