id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-344105-9bw9rm6e	Teraguchi, Shunsuke	Methods for sequence and structural analysis of B and T cell receptor repertoires	2020-07-17		.txt	text/plain	6933	390	46	After describing the recent sequencing technologies for immune receptor repertoires, we survey structural modeling methods for BCR and TCRs, along with methods for clustering such models. We review downstream analyses, including BCR and TCR epitope prediction, antibody-antigen docking and TCR-peptide-MHC Modeling. The Immcantation framework [18, 19] and TRUST (TCR repertoire utilities for solid tissue) [20] can be also used for the same purpose among many other available tools not covered here Though single chain information alone is usually not enough to explain the binding of the receptor to the target epitope, there are several methods applicable to bulk sequencing data. Based on the observation that there are specific positions in TCR CDR3 regions that contact antigen peptides and that the presence of particular sequence motifs can define TCR clusters, Glanville et al., developed the GLIPH (grouping of lymphocyte interactions by paratope hotspots) algorithm [63, 64] .	./cache/cord-344105-9bw9rm6e.txt	./txt/cord-344105-9bw9rm6e.txt