id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-355075-ieb35upi	Papenfuss, Anthony T	The immune gene repertoire of an important viral reservoir, the Australian black flying fox	2012-06-20		.txt	text/plain	8952	480	54	alecto transcriptome provides information on a variety of immune genes not previously identified in any bat species and represents an important starting point for examining the antiviral activity of these molecules. To enrich for sequences corresponding to cytokines and innate immune genes, the second dataset was derived from pooled total RNA obtained from mitogen-stimulated spleen, white blood cells and lymph node and unstimulated thymus and bone marrow obtained from one pregnant female and one adult male flying fox. A full length transcript, encoding a 667 amino acid protein was identified in our bat transcriptome datasets and found to be orthologous to Mx1 based on comparison with known mammalian Mx1 and Mx2 family members (Figure 4a and data not shown). Genes involved in the adaptive immune system, including MHC class I and II genes and T and B cell receptors and co-receptors were highly represented in both the thymus and pooled datasets providing evidence that bats have all of the components necessary to mount an adaptive immune response.	./cache/cord-355075-ieb35upi.txt	./txt/cord-355075-ieb35upi.txt