id sid tid token lemma pos cord-007636-kfd0wqdx 1 1 key key JJ cord-007636-kfd0wqdx 1 2 : : : cord-007636-kfd0wqdx 1 3 cord-007636-kfd0wqdx cord-007636-kfd0wqdx NNP cord-007636-kfd0wqdx 1 4 authors author NNS cord-007636-kfd0wqdx 1 5 : : : cord-007636-kfd0wqdx 1 6 Wen Wen NNP cord-007636-kfd0wqdx 1 7 , , , cord-007636-kfd0wqdx 1 8 P. P. NNP cord-007636-kfd0wqdx 1 9 ; ; : cord-007636-kfd0wqdx 1 10 Loeffler Loeffler NNP cord-007636-kfd0wqdx 1 11 , , , cord-007636-kfd0wqdx 1 12 J.S. J.S. NNP cord-007636-kfd0wqdx 1 13 ; ; : cord-007636-kfd0wqdx 1 14 Morris Morris NNP cord-007636-kfd0wqdx 1 15 , , , cord-007636-kfd0wqdx 1 16 J.H. J.H. NNP cord-007636-kfd0wqdx 1 17 ; ; : cord-007636-kfd0wqdx 1 18 Lampson Lampson NNP cord-007636-kfd0wqdx 1 19 , , , cord-007636-kfd0wqdx 1 20 L.A. L.A. NNP cord-007636-kfd0wqdx 1 21 title title NN cord-007636-kfd0wqdx 1 22 : : : cord-007636-kfd0wqdx 2 1 The the DT cord-007636-kfd0wqdx 2 2 effects effect NNS cord-007636-kfd0wqdx 2 3 of of IN cord-007636-kfd0wqdx 2 4 irradiation irradiation NN cord-007636-kfd0wqdx 2 5 on on IN cord-007636-kfd0wqdx 2 6 major major JJ cord-007636-kfd0wqdx 2 7 histocampatibility histocampatibility NN cord-007636-kfd0wqdx 2 8 complex complex JJ cord-007636-kfd0wqdx 2 9 expression expression NN cord-007636-kfd0wqdx 2 10 and and CC cord-007636-kfd0wqdx 2 11 lymphocytic lymphocytic JJ cord-007636-kfd0wqdx 2 12 infiltration infiltration NN cord-007636-kfd0wqdx 2 13 in in IN cord-007636-kfd0wqdx 2 14 the the DT cord-007636-kfd0wqdx 2 15 normal normal JJ cord-007636-kfd0wqdx 2 16 rat rat NN cord-007636-kfd0wqdx 2 17 brain brain NN cord-007636-kfd0wqdx 2 18 and and CC cord-007636-kfd0wqdx 2 19 the the DT cord-007636-kfd0wqdx 2 20 9L 9l CD cord-007636-kfd0wqdx 2 21 gliosarcoma gliosarcoma NNP cord-007636-kfd0wqdx 2 22 brain brain NNP cord-007636-kfd0wqdx 2 23 tumor tumor NN cord-007636-kfd0wqdx 2 24 model model NN cord-007636-kfd0wqdx 2 25 date date NN cord-007636-kfd0wqdx 2 26 : : : cord-007636-kfd0wqdx 2 27 2002 2002 CD cord-007636-kfd0wqdx 2 28 - - HYPH cord-007636-kfd0wqdx 2 29 11 11 CD cord-007636-kfd0wqdx 2 30 - - SYM cord-007636-kfd0wqdx 2 31 13 13 CD cord-007636-kfd0wqdx 2 32 journal journal NN cord-007636-kfd0wqdx 2 33 : : : cord-007636-kfd0wqdx 2 34 J J NNP cord-007636-kfd0wqdx 2 35 Neuroimmunol Neuroimmunol NNP cord-007636-kfd0wqdx 2 36 DOI DOI NNP cord-007636-kfd0wqdx 2 37 : : : cord-007636-kfd0wqdx 2 38 10.1016/0165 10.1016/0165 CD cord-007636-kfd0wqdx 2 39 - - HYPH cord-007636-kfd0wqdx 2 40 5728(90)90074-w 5728(90)90074-w CD cord-007636-kfd0wqdx 2 41 sha sha NN cord-007636-kfd0wqdx 2 42 : : : cord-007636-kfd0wqdx 3 1 88e59988d0761ab9e2ccfb6b19d1a697df14828f 88e59988d0761ab9e2ccfb6b19d1a697df14828f CD cord-007636-kfd0wqdx 3 2 doc_id doc_id CD cord-007636-kfd0wqdx 3 3 : : : cord-007636-kfd0wqdx 4 1 7636 7636 CD cord-007636-kfd0wqdx 4 2 cord_uid cord_uid NNS cord-007636-kfd0wqdx 4 3 : : : cord-007636-kfd0wqdx 4 4 kfd0wqdx kfd0wqdx XX cord-007636-kfd0wqdx 5 1 The the DT cord-007636-kfd0wqdx 5 2 effects effect NNS cord-007636-kfd0wqdx 5 3 of of IN cord-007636-kfd0wqdx 5 4 irradiation irradiation NN cord-007636-kfd0wqdx 5 5 on on IN cord-007636-kfd0wqdx 5 6 major major JJ cord-007636-kfd0wqdx 5 7 histocompatibility histocompatibility NN cord-007636-kfd0wqdx 5 8 complex complex NN cord-007636-kfd0wqdx 5 9 ( ( -LRB- cord-007636-kfd0wqdx 5 10 MHC MHC NNP cord-007636-kfd0wqdx 5 11 ) ) -RRB- cord-007636-kfd0wqdx 5 12 expression expression NN cord-007636-kfd0wqdx 5 13 and and CC cord-007636-kfd0wqdx 5 14 lymphocytic lymphocytic JJ cord-007636-kfd0wqdx 5 15 infiltration infiltration NN cord-007636-kfd0wqdx 5 16 in in IN cord-007636-kfd0wqdx 5 17 the the DT cord-007636-kfd0wqdx 5 18 normal normal JJ cord-007636-kfd0wqdx 5 19 rat rat NN cord-007636-kfd0wqdx 5 20 brain brain NN cord-007636-kfd0wqdx 5 21 and and CC cord-007636-kfd0wqdx 5 22 the the DT cord-007636-kfd0wqdx 5 23 9L 9l CD cord-007636-kfd0wqdx 5 24 gliosarcoma gliosarcoma NNP cord-007636-kfd0wqdx 5 25 brain brain NNP cord-007636-kfd0wqdx 5 26 tumor tumor NN cord-007636-kfd0wqdx 5 27 model model NN cord-007636-kfd0wqdx 5 28 were be VBD cord-007636-kfd0wqdx 5 29 examined examine VBN cord-007636-kfd0wqdx 5 30 . . . cord-007636-kfd0wqdx 6 1 Doses dose NNS cord-007636-kfd0wqdx 6 2 of of IN cord-007636-kfd0wqdx 6 3 irradiation irradiation NN cord-007636-kfd0wqdx 6 4 administered administer VBN cord-007636-kfd0wqdx 6 5 were be VBD cord-007636-kfd0wqdx 6 6 biologically biologically RB cord-007636-kfd0wqdx 6 7 equivalent equivalent JJ cord-007636-kfd0wqdx 6 8 to to IN cord-007636-kfd0wqdx 6 9 that that DT cord-007636-kfd0wqdx 6 10 used use VBN cord-007636-kfd0wqdx 6 11 in in IN cord-007636-kfd0wqdx 6 12 the the DT cord-007636-kfd0wqdx 6 13 treatment treatment NN cord-007636-kfd0wqdx 6 14 of of IN cord-007636-kfd0wqdx 6 15 patients patient NNS cord-007636-kfd0wqdx 6 16 with with IN cord-007636-kfd0wqdx 6 17 malignant malignant JJ cord-007636-kfd0wqdx 6 18 gliomas glioma NNS cord-007636-kfd0wqdx 6 19 . . . cord-007636-kfd0wqdx 7 1 No no DT cord-007636-kfd0wqdx 7 2 significant significant JJ cord-007636-kfd0wqdx 7 3 change change NN cord-007636-kfd0wqdx 7 4 in in IN cord-007636-kfd0wqdx 7 5 immune immune JJ cord-007636-kfd0wqdx 7 6 parameters parameter NNS cord-007636-kfd0wqdx 7 7 was be VBD cord-007636-kfd0wqdx 7 8 observed observe VBN cord-007636-kfd0wqdx 7 9 following follow VBG cord-007636-kfd0wqdx 7 10 irradiation irradiation NN cord-007636-kfd0wqdx 7 11 in in IN cord-007636-kfd0wqdx 7 12 the the DT cord-007636-kfd0wqdx 7 13 normal normal JJ cord-007636-kfd0wqdx 7 14 rat rat NN cord-007636-kfd0wqdx 7 15 brain brain NN cord-007636-kfd0wqdx 7 16 . . . cord-007636-kfd0wqdx 8 1 In in IN cord-007636-kfd0wqdx 8 2 the the DT cord-007636-kfd0wqdx 8 3 9L 9l CD cord-007636-kfd0wqdx 8 4 gliosarcoma gliosarcoma NNP cord-007636-kfd0wqdx 8 5 model model NN cord-007636-kfd0wqdx 8 6 irradiation irradiation NN cord-007636-kfd0wqdx 8 7 did do VBD cord-007636-kfd0wqdx 8 8 not not RB cord-007636-kfd0wqdx 8 9 suppress suppress VB cord-007636-kfd0wqdx 8 10 MHC MHC NNP cord-007636-kfd0wqdx 8 11 expression expression NN cord-007636-kfd0wqdx 8 12 or or CC cord-007636-kfd0wqdx 8 13 lymphocytic lymphocytic JJ cord-007636-kfd0wqdx 8 14 infiltration infiltration NN cord-007636-kfd0wqdx 8 15 . . . cord-007636-kfd0wqdx 9 1 These these DT cord-007636-kfd0wqdx 9 2 findings finding NNS cord-007636-kfd0wqdx 9 3 suggest suggest VBP cord-007636-kfd0wqdx 9 4 that that IN cord-007636-kfd0wqdx 9 5 prior prior JJ cord-007636-kfd0wqdx 9 6 exposure exposure NN cord-007636-kfd0wqdx 9 7 to to IN cord-007636-kfd0wqdx 9 8 therapeutic therapeutic JJ cord-007636-kfd0wqdx 9 9 irradiation irradiation NN cord-007636-kfd0wqdx 9 10 need nee MD cord-007636-kfd0wqdx 9 11 not not RB cord-007636-kfd0wqdx 9 12 adversely adversely RB cord-007636-kfd0wqdx 9 13 affect affect VB cord-007636-kfd0wqdx 9 14 subsequent subsequent JJ cord-007636-kfd0wqdx 9 15 immunotherapies immunotherapy NNS cord-007636-kfd0wqdx 9 16 , , , cord-007636-kfd0wqdx 9 17 and and CC cord-007636-kfd0wqdx 9 18 provide provide VB cord-007636-kfd0wqdx 9 19 a a DT cord-007636-kfd0wqdx 9 20 foundation foundation NN cord-007636-kfd0wqdx 9 21 for for IN cord-007636-kfd0wqdx 9 22 future future JJ cord-007636-kfd0wqdx 9 23 studies study NNS cord-007636-kfd0wqdx 9 24 of of IN cord-007636-kfd0wqdx 9 25 immunomodulation immunomodulation NN cord-007636-kfd0wqdx 9 26 in in IN cord-007636-kfd0wqdx 9 27 the the DT cord-007636-kfd0wqdx 9 28 irradiated irradiate VBN cord-007636-kfd0wqdx 9 29 brain brain NN cord-007636-kfd0wqdx 9 30 . . . cord-007636-kfd0wqdx 10 1 The the DT cord-007636-kfd0wqdx 10 2 limitation limitation NN cord-007636-kfd0wqdx 10 3 of of IN cord-007636-kfd0wqdx 10 4 current current JJ cord-007636-kfd0wqdx 10 5 therapy therapy NN cord-007636-kfd0wqdx 10 6 for for IN cord-007636-kfd0wqdx 10 7 patients patient NNS cord-007636-kfd0wqdx 10 8 with with IN cord-007636-kfd0wqdx 10 9 malignant malignant JJ cord-007636-kfd0wqdx 10 10 glioma glioma NN cord-007636-kfd0wqdx 10 11 has have VBZ cord-007636-kfd0wqdx 10 12 led lead VBN cord-007636-kfd0wqdx 10 13 to to IN cord-007636-kfd0wqdx 10 14 renewed renew VBN cord-007636-kfd0wqdx 10 15 interest interest NN cord-007636-kfd0wqdx 10 16 in in IN cord-007636-kfd0wqdx 10 17 immunotherapy immunotherapy NN cord-007636-kfd0wqdx 10 18 as as IN cord-007636-kfd0wqdx 10 19 an an DT cord-007636-kfd0wqdx 10 20 adjunctive adjunctive JJ cord-007636-kfd0wqdx 10 21 mode mode NN cord-007636-kfd0wqdx 10 22 of of IN cord-007636-kfd0wqdx 10 23 treatment treatment NN cord-007636-kfd0wqdx 10 24 . . . cord-007636-kfd0wqdx 11 1 Immunotherapy immunotherapy NN cord-007636-kfd0wqdx 11 2 is be VBZ cord-007636-kfd0wqdx 11 3 likely likely JJ cord-007636-kfd0wqdx 11 4 to to TO cord-007636-kfd0wqdx 11 5 be be VB cord-007636-kfd0wqdx 11 6 most most RBS cord-007636-kfd0wqdx 11 7 effective effective JJ cord-007636-kfd0wqdx 11 8 in in IN cord-007636-kfd0wqdx 11 9 the the DT cord-007636-kfd0wqdx 11 10 early early JJ cord-007636-kfd0wqdx 11 11 weeks week NNS cord-007636-kfd0wqdx 11 12 following follow VBG cord-007636-kfd0wqdx 11 13 maximal maximal JJ cord-007636-kfd0wqdx 11 14 cytore cytore NN cord-007636-kfd0wqdx 11 15 - - HYPH cord-007636-kfd0wqdx 11 16 duction duction NN cord-007636-kfd0wqdx 11 17 with with IN cord-007636-kfd0wqdx 11 18 surgery surgery NN cord-007636-kfd0wqdx 11 19 and and CC cord-007636-kfd0wqdx 11 20 radiation radiation NN cord-007636-kfd0wqdx 11 21 therapy therapy NN cord-007636-kfd0wqdx 11 22 . . . cord-007636-kfd0wqdx 12 1 The the DT cord-007636-kfd0wqdx 12 2 immunosuppressive immunosuppressive JJ cord-007636-kfd0wqdx 12 3 effects effect NNS cord-007636-kfd0wqdx 12 4 of of IN cord-007636-kfd0wqdx 12 5 ionizing ionize VBG cord-007636-kfd0wqdx 12 6 radiation radiation NN cord-007636-kfd0wqdx 12 7 are be VBP cord-007636-kfd0wqdx 12 8 well well RB cord-007636-kfd0wqdx 12 9 known know VBN cord-007636-kfd0wqdx 13 1 ( ( -LRB- cord-007636-kfd0wqdx 13 2 Markoe Markoe NNP cord-007636-kfd0wqdx 13 3 and and CC cord-007636-kfd0wqdx 13 4 Saluk Saluk NNP cord-007636-kfd0wqdx 13 5 , , , cord-007636-kfd0wqdx 13 6 1987 1987 CD cord-007636-kfd0wqdx 13 7 ) ) -RRB- cord-007636-kfd0wqdx 13 8 . . . cord-007636-kfd0wqdx 14 1 Irradiation irradiation NN cord-007636-kfd0wqdx 14 2 has have VBZ cord-007636-kfd0wqdx 14 3 been be VBN cord-007636-kfd0wqdx 14 4 shown show VBN cord-007636-kfd0wqdx 14 5 to to TO cord-007636-kfd0wqdx 14 6 decrease decrease VB cord-007636-kfd0wqdx 14 7 major major JJ cord-007636-kfd0wqdx 14 8 histocompatibility histocompatibility NN cord-007636-kfd0wqdx 14 9 complex complex NN cord-007636-kfd0wqdx 14 10 ( ( -LRB- cord-007636-kfd0wqdx 14 11 MHC MHC NNP cord-007636-kfd0wqdx 14 12 ) ) -RRB- cord-007636-kfd0wqdx 14 13 expression expression NN cord-007636-kfd0wqdx 14 14 and and CC cord-007636-kfd0wqdx 14 15 lymphocytic lymphocytic JJ cord-007636-kfd0wqdx 14 16 infiltration infiltration NN cord-007636-kfd0wqdx 14 17 in in IN cord-007636-kfd0wqdx 14 18 melanoma melanoma NN cord-007636-kfd0wqdx 14 19 ( ( -LRB- cord-007636-kfd0wqdx 14 20 Jager Jager NNP cord-007636-kfd0wqdx 14 21 et et NNP cord-007636-kfd0wqdx 14 22 al al NNP cord-007636-kfd0wqdx 14 23 . . NNP cord-007636-kfd0wqdx 14 24 , , , cord-007636-kfd0wqdx 14 25 1988 1988 CD cord-007636-kfd0wqdx 14 26 ) ) -RRB- cord-007636-kfd0wqdx 14 27 and and CC cord-007636-kfd0wqdx 14 28 reduce reduce VB cord-007636-kfd0wqdx 14 29 the the DT cord-007636-kfd0wqdx 14 30 effectiveness effectiveness NN cord-007636-kfd0wqdx 14 31 of of IN cord-007636-kfd0wqdx 14 32 some some DT cord-007636-kfd0wqdx 14 33 forms form NNS cord-007636-kfd0wqdx 14 34 of of IN cord-007636-kfd0wqdx 14 35 immunotherapy immunotherapy NN cord-007636-kfd0wqdx 14 36 ( ( -LRB- cord-007636-kfd0wqdx 14 37 Ettinghausen Ettinghausen NNP cord-007636-kfd0wqdx 14 38 et et NNP cord-007636-kfd0wqdx 14 39 al al NNP cord-007636-kfd0wqdx 14 40 . . NNP cord-007636-kfd0wqdx 14 41 , , , cord-007636-kfd0wqdx 14 42 1985 1985 CD cord-007636-kfd0wqdx 14 43 ) ) -RRB- cord-007636-kfd0wqdx 14 44 . . . cord-007636-kfd0wqdx 15 1 However however RB cord-007636-kfd0wqdx 15 2 , , , cord-007636-kfd0wqdx 15 3 under under IN cord-007636-kfd0wqdx 15 4 certain certain JJ cord-007636-kfd0wqdx 15 5 circumstances circumstance NNS cord-007636-kfd0wqdx 15 6 , , , cord-007636-kfd0wqdx 15 7 irradiation irradiation NN cord-007636-kfd0wqdx 15 8 can can MD cord-007636-kfd0wqdx 15 9 enhance enhance VB cord-007636-kfd0wqdx 15 10 the the DT cord-007636-kfd0wqdx 15 11 host host NN cord-007636-kfd0wqdx 15 12 immune immune JJ cord-007636-kfd0wqdx 15 13 response response NN cord-007636-kfd0wqdx 15 14 , , , cord-007636-kfd0wqdx 15 15 and and CC cord-007636-kfd0wqdx 15 16 increase increase VB cord-007636-kfd0wqdx 15 17 the the DT cord-007636-kfd0wqdx 15 18 efficacy efficacy NN cord-007636-kfd0wqdx 15 19 of of IN cord-007636-kfd0wqdx 15 20 immunotherapeutic immunotherapeutic JJ cord-007636-kfd0wqdx 15 21 regimens regimen NNS cord-007636-kfd0wqdx 15 22 ( ( -LRB- cord-007636-kfd0wqdx 15 23 Hellstrom Hellstrom NNP cord-007636-kfd0wqdx 15 24 et et NNP cord-007636-kfd0wqdx 15 25 al al NNP cord-007636-kfd0wqdx 15 26 . . NNP cord-007636-kfd0wqdx 15 27 , , , cord-007636-kfd0wqdx 15 28 1978 1978 CD cord-007636-kfd0wqdx 15 29 ; ; : cord-007636-kfd0wqdx 16 1 Tilkin Tilkin NNP cord-007636-kfd0wqdx 16 2 et et FW cord-007636-kfd0wqdx 16 3 al al NNP cord-007636-kfd0wqdx 16 4 . . . cord-007636-kfd0wqdx 17 1 , , , cord-007636-kfd0wqdx 17 2 1981 1981 CD cord-007636-kfd0wqdx 17 3 ; ; : cord-007636-kfd0wqdx 17 4 North North NNP cord-007636-kfd0wqdx 17 5 , , , cord-007636-kfd0wqdx 17 6 1984 1984 CD cord-007636-kfd0wqdx 17 7 ) ) -RRB- cord-007636-kfd0wqdx 17 8 . . . cord-007636-kfd0wqdx 18 1 Recent recent JJ cord-007636-kfd0wqdx 18 2 work work NN cord-007636-kfd0wqdx 18 3 has have VBZ cord-007636-kfd0wqdx 18 4 defined define VBN cord-007636-kfd0wqdx 18 5 a a DT cord-007636-kfd0wqdx 18 6 growing grow VBG cord-007636-kfd0wqdx 18 7 number number NN cord-007636-kfd0wqdx 18 8 of of IN cord-007636-kfd0wqdx 18 9 pathological pathological JJ cord-007636-kfd0wqdx 18 10 and and CC cord-007636-kfd0wqdx 18 11 experimental experimental JJ cord-007636-kfd0wqdx 18 12 situations situation NNS cord-007636-kfd0wqdx 18 13 in in IN cord-007636-kfd0wqdx 18 14 which which WDT cord-007636-kfd0wqdx 18 15 the the DT cord-007636-kfd0wqdx 18 16 brain brain NN cord-007636-kfd0wqdx 18 17 's 's POS cord-007636-kfd0wqdx 18 18 immune immune JJ cord-007636-kfd0wqdx 18 19 environment environment NN cord-007636-kfd0wqdx 18 20 is be VBZ cord-007636-kfd0wqdx 18 21 altered alter VBN cord-007636-kfd0wqdx 18 22 ( ( -LRB- cord-007636-kfd0wqdx 18 23 Lampson Lampson NNP cord-007636-kfd0wqdx 18 24 , , , cord-007636-kfd0wqdx 18 25 1987 1987 CD cord-007636-kfd0wqdx 18 26 ) ) -RRB- cord-007636-kfd0wqdx 18 27 . . . cord-007636-kfd0wqdx 19 1 Yet yet CC cord-007636-kfd0wqdx 19 2 few few JJ cord-007636-kfd0wqdx 19 3 studies study NNS cord-007636-kfd0wqdx 19 4 have have VBP cord-007636-kfd0wqdx 19 5 addressed address VBN cord-007636-kfd0wqdx 19 6 the the DT cord-007636-kfd0wqdx 19 7 possible possible JJ cord-007636-kfd0wqdx 19 8 effects effect NNS cord-007636-kfd0wqdx 19 9 of of IN cord-007636-kfd0wqdx 19 10 irradiation irradiation NN cord-007636-kfd0wqdx 19 11 on on IN cord-007636-kfd0wqdx 19 12 immune immune JJ cord-007636-kfd0wqdx 19 13 parameters parameter NNS cord-007636-kfd0wqdx 19 14 in in IN cord-007636-kfd0wqdx 19 15 the the DT cord-007636-kfd0wqdx 19 16 normal normal JJ cord-007636-kfd0wqdx 19 17 or or CC cord-007636-kfd0wqdx 19 18 tumor tumor NN cord-007636-kfd0wqdx 19 19 - - HYPH cord-007636-kfd0wqdx 19 20 bearing bear VBG cord-007636-kfd0wqdx 19 21 brain brain NN cord-007636-kfd0wqdx 19 22 . . . cord-007636-kfd0wqdx 20 1 In in IN cord-007636-kfd0wqdx 20 2 this this DT cord-007636-kfd0wqdx 20 3 study study NN cord-007636-kfd0wqdx 20 4 , , , cord-007636-kfd0wqdx 20 5 we -PRON- PRP cord-007636-kfd0wqdx 20 6 examined examine VBD cord-007636-kfd0wqdx 20 7 the the DT cord-007636-kfd0wqdx 20 8 effects effect NNS cord-007636-kfd0wqdx 20 9 of of IN cord-007636-kfd0wqdx 20 10 irradiation irradiation NN cord-007636-kfd0wqdx 20 11 , , , cord-007636-kfd0wqdx 20 12 biologically biologically RB cord-007636-kfd0wqdx 20 13 equivalent equivalent JJ cord-007636-kfd0wqdx 20 14 to to IN cord-007636-kfd0wqdx 20 15 that that DT cord-007636-kfd0wqdx 20 16 used use VBN cord-007636-kfd0wqdx 20 17 in in IN cord-007636-kfd0wqdx 20 18 the the DT cord-007636-kfd0wqdx 20 19 treatment treatment NN cord-007636-kfd0wqdx 20 20 of of IN cord-007636-kfd0wqdx 20 21 patients patient NNS cord-007636-kfd0wqdx 20 22 with with IN cord-007636-kfd0wqdx 20 23 malignant malignant JJ cord-007636-kfd0wqdx 20 24 gliomas glioma NNS cord-007636-kfd0wqdx 20 25 , , , cord-007636-kfd0wqdx 20 26 during during IN cord-007636-kfd0wqdx 20 27 the the DT cord-007636-kfd0wqdx 20 28 time time NN cord-007636-kfd0wqdx 20 29 period period NN cord-007636-kfd0wqdx 20 30 when when WRB cord-007636-kfd0wqdx 20 31 immunotherapy immunotherapy NN cord-007636-kfd0wqdx 20 32 is be VBZ cord-007636-kfd0wqdx 20 33 most most RBS cord-007636-kfd0wqdx 20 34 likely likely JJ cord-007636-kfd0wqdx 20 35 to to TO cord-007636-kfd0wqdx 20 36 be be VB cord-007636-kfd0wqdx 20 37 attempted attempt VBN cord-007636-kfd0wqdx 20 38 . . . cord-007636-kfd0wqdx 21 1 MHC MHC NNP cord-007636-kfd0wqdx 21 2 expression expression NN cord-007636-kfd0wqdx 21 3 and and CC cord-007636-kfd0wqdx 21 4 lymphocyte lymphocyte NN cord-007636-kfd0wqdx 21 5 infiltration infiltration NN cord-007636-kfd0wqdx 21 6 were be VBD cord-007636-kfd0wqdx 21 7 examined examine VBN cord-007636-kfd0wqdx 21 8 in in IN cord-007636-kfd0wqdx 21 9 irradiated irradiate VBN cord-007636-kfd0wqdx 21 10 tumor tumor NN cord-007636-kfd0wqdx 21 11 - - HYPH cord-007636-kfd0wqdx 21 12 free free JJ cord-007636-kfd0wqdx 21 13 brains brain NNS cord-007636-kfd0wqdx 21 14 and and CC cord-007636-kfd0wqdx 21 15 in in IN cord-007636-kfd0wqdx 21 16 the the DT cord-007636-kfd0wqdx 21 17 9L 9l CD cord-007636-kfd0wqdx 21 18 gliosarcoma gliosarcoma NNP cord-007636-kfd0wqdx 21 19 brain brain NNP cord-007636-kfd0wqdx 21 20 tumor tumor NN cord-007636-kfd0wqdx 21 21 model model NN cord-007636-kfd0wqdx 21 22 . . . cord-007636-kfd0wqdx 22 1 Rats rat NNS cord-007636-kfd0wqdx 22 2 . . . cord-007636-kfd0wqdx 23 1 Female female JJ cord-007636-kfd0wqdx 23 2 CDF CDF NNP cord-007636-kfd0wqdx 23 3 rats rat NNS cord-007636-kfd0wqdx 23 4 ( ( -LRB- cord-007636-kfd0wqdx 23 5 125 125 CD cord-007636-kfd0wqdx 23 6 - - SYM cord-007636-kfd0wqdx 23 7 150 150 CD cord-007636-kfd0wqdx 23 8 g g NN cord-007636-kfd0wqdx 23 9 ) ) -RRB- cord-007636-kfd0wqdx 23 10 were be VBD cord-007636-kfd0wqdx 23 11 purchased purchase VBN cord-007636-kfd0wqdx 23 12 from from IN cord-007636-kfd0wqdx 23 13 Charles Charles NNP cord-007636-kfd0wqdx 23 14 River River NNP cord-007636-kfd0wqdx 23 15 Lab Lab NNP cord-007636-kfd0wqdx 23 16 . . . cord-007636-kfd0wqdx 24 1 ( ( -LRB- cord-007636-kfd0wqdx 24 2 Wilmington Wilmington NNP cord-007636-kfd0wqdx 24 3 , , , cord-007636-kfd0wqdx 24 4 MA MA NNP cord-007636-kfd0wqdx 24 5 , , , cord-007636-kfd0wqdx 24 6 U.S.A. U.S.A. NNP cord-007636-kfd0wqdx 24 7 ) ) -RRB- cord-007636-kfd0wqdx 24 8 . . . cord-007636-kfd0wqdx 25 1 Antibodies antibody NNS cord-007636-kfd0wqdx 25 2 . . . cord-007636-kfd0wqdx 26 1 Immunocytochemistry Immunocytochemistry NNP cord-007636-kfd0wqdx 26 2 was be VBD cord-007636-kfd0wqdx 26 3 carried carry VBN cord-007636-kfd0wqdx 26 4 out out RP cord-007636-kfd0wqdx 26 5 with with IN cord-007636-kfd0wqdx 26 6 rabbit rabbit NN cord-007636-kfd0wqdx 26 7 serum serum NN cord-007636-kfd0wqdx 26 8 against against IN cord-007636-kfd0wqdx 26 9 glial glial JJ cord-007636-kfd0wqdx 26 10 fibrillary fibrillary JJ cord-007636-kfd0wqdx 26 11 acidic acidic JJ cord-007636-kfd0wqdx 26 12 protein protein NN cord-007636-kfd0wqdx 26 13 ( ( -LRB- cord-007636-kfd0wqdx 26 14 GFAP GFAP NNP cord-007636-kfd0wqdx 26 15 ) ) -RRB- cord-007636-kfd0wqdx 26 16 ( ( -LRB- cord-007636-kfd0wqdx 26 17 Dako Dako NNP cord-007636-kfd0wqdx 26 18 ) ) -RRB- cord-007636-kfd0wqdx 26 19 and and CC cord-007636-kfd0wqdx 26 20 the the DT cord-007636-kfd0wqdx 26 21 monoclonal monoclonal JJ cord-007636-kfd0wqdx 26 22 antibodies antibody NNS cord-007636-kfd0wqdx 26 23 OX6 OX6 NNP cord-007636-kfd0wqdx 26 24 ( ( -LRB- cord-007636-kfd0wqdx 26 25 class class NN cord-007636-kfd0wqdx 26 26 II II NNP cord-007636-kfd0wqdx 26 27 ) ) -RRB- cord-007636-kfd0wqdx 26 28 , , , cord-007636-kfd0wqdx 26 29 OX18 OX18 NNP cord-007636-kfd0wqdx 27 1 ( ( -LRB- cord-007636-kfd0wqdx 27 2 class class NN cord-007636-kfd0wqdx 27 3 I -PRON- PRP cord-007636-kfd0wqdx 27 4 MHC MHC NNP cord-007636-kfd0wqdx 27 5 ) ) -RRB- cord-007636-kfd0wqdx 27 6 , , , cord-007636-kfd0wqdx 27 7 OX1 OX1 NNP cord-007636-kfd0wqdx 27 8 ( ( -LRB- cord-007636-kfd0wqdx 27 9 LCA LCA NNP cord-007636-kfd0wqdx 27 10 ) ) -RRB- cord-007636-kfd0wqdx 27 11 , , , cord-007636-kfd0wqdx 27 12 W3/13 W3/13 NNP cord-007636-kfd0wqdx 27 13 ( ( -LRB- cord-007636-kfd0wqdx 27 14 T t NN cord-007636-kfd0wqdx 27 15 cells cell NNS cord-007636-kfd0wqdx 27 16 ) ) -RRB- cord-007636-kfd0wqdx 27 17 , , . cord-007636-kfd0wqdx 28 1 W3/25 w3/25 NN cord-007636-kfd0wqdx 28 2 ( ( -LRB- cord-007636-kfd0wqdx 28 3 T T NNP cord-007636-kfd0wqdx 28 4 helper helper NN cord-007636-kfd0wqdx 28 5 ) ) -RRB- cord-007636-kfd0wqdx 28 6 , , , cord-007636-kfd0wqdx 28 7 OX8 OX8 NNP cord-007636-kfd0wqdx 28 8 ( ( -LRB- cord-007636-kfd0wqdx 28 9 T T NNP cord-007636-kfd0wqdx 28 10 cytotoxic cytotoxic JJ cord-007636-kfd0wqdx 28 11 / / SYM cord-007636-kfd0wqdx 28 12 suppressor suppressor NN cord-007636-kfd0wqdx 28 13 ) ) -RRB- cord-007636-kfd0wqdx 28 14 , , , cord-007636-kfd0wqdx 28 15 OX33 OX33 NNP cord-007636-kfd0wqdx 28 16 ( ( -LRB- cord-007636-kfd0wqdx 28 17 B b NN cord-007636-kfd0wqdx 28 18 cells cell NNS cord-007636-kfd0wqdx 28 19 ) ) -RRB- cord-007636-kfd0wqdx 28 20 and and CC cord-007636-kfd0wqdx 28 21 OX42 OX42 NNP cord-007636-kfd0wqdx 28 22 ( ( -LRB- cord-007636-kfd0wqdx 28 23 microglia microglia NNP cord-007636-kfd0wqdx 28 24 ) ) -RRB- cord-007636-kfd0wqdx 28 25 using use VBG cord-007636-kfd0wqdx 28 26 a a DT cord-007636-kfd0wqdx 28 27 modification modification NN cord-007636-kfd0wqdx 28 28 of of IN cord-007636-kfd0wqdx 28 29 the the DT cord-007636-kfd0wqdx 28 30 ABC ABC NNP cord-007636-kfd0wqdx 28 31 Vectastain Vectastain NNP cord-007636-kfd0wqdx 28 32 procedure procedure NN cord-007636-kfd0wqdx 28 33 ( ( -LRB- cord-007636-kfd0wqdx 28 34 Whelan Whelan NNP cord-007636-kfd0wqdx 28 35 et et NNP cord-007636-kfd0wqdx 28 36 al al NNP cord-007636-kfd0wqdx 28 37 . . NNP cord-007636-kfd0wqdx 28 38 , , , cord-007636-kfd0wqdx 28 39 1986 1986 CD cord-007636-kfd0wqdx 28 40 ) ) -RRB- cord-007636-kfd0wqdx 28 41 . . . cord-007636-kfd0wqdx 29 1 Briefly briefly RB cord-007636-kfd0wqdx 29 2 , , , cord-007636-kfd0wqdx 29 3 sections section NNS cord-007636-kfd0wqdx 29 4 were be VBD cord-007636-kfd0wqdx 29 5 fixed fix VBN cord-007636-kfd0wqdx 29 6 in in IN cord-007636-kfd0wqdx 29 7 absolute absolute JJ cord-007636-kfd0wqdx 29 8 methanol methanol NN cord-007636-kfd0wqdx 29 9 ( ( -LRB- cord-007636-kfd0wqdx 29 10 -20 -20 NNP cord-007636-kfd0wqdx 29 11 ° ° NN cord-007636-kfd0wqdx 29 12 C c NN cord-007636-kfd0wqdx 29 13 for for IN cord-007636-kfd0wqdx 29 14 2 2 CD cord-007636-kfd0wqdx 29 15 min min NNP cord-007636-kfd0wqdx 29 16 ) ) -RRB- cord-007636-kfd0wqdx 29 17 and and CC cord-007636-kfd0wqdx 29 18 incubated incubate VBN cord-007636-kfd0wqdx 29 19 in in IN cord-007636-kfd0wqdx 29 20 succession succession NN cord-007636-kfd0wqdx 29 21 with with IN cord-007636-kfd0wqdx 29 22 2 2 CD cord-007636-kfd0wqdx 29 23 % % NN cord-007636-kfd0wqdx 29 24 normal normal JJ cord-007636-kfd0wqdx 29 25 goat goat NN cord-007636-kfd0wqdx 29 26 serum serum NN cord-007636-kfd0wqdx 29 27 ( ( -LRB- cord-007636-kfd0wqdx 29 28 30 30 CD cord-007636-kfd0wqdx 29 29 rain rain NN cord-007636-kfd0wqdx 29 30 ) ) -RRB- cord-007636-kfd0wqdx 29 31 , , , cord-007636-kfd0wqdx 29 32 diluted dilute VBN cord-007636-kfd0wqdx 29 33 primary primary JJ cord-007636-kfd0wqdx 29 34 antibody antibody NN cord-007636-kfd0wqdx 29 35 ( ( -LRB- cord-007636-kfd0wqdx 29 36 4 4 CD cord-007636-kfd0wqdx 29 37 ° ° NN cord-007636-kfd0wqdx 29 38 C c NN cord-007636-kfd0wqdx 29 39 , , , cord-007636-kfd0wqdx 29 40 overnight overnight RB cord-007636-kfd0wqdx 29 41 ) ) -RRB- cord-007636-kfd0wqdx 29 42 , , , cord-007636-kfd0wqdx 29 43 biotinylated biotinylated NNP cord-007636-kfd0wqdx 29 44 horse horse NNP cord-007636-kfd0wqdx 29 45 antimouse antimouse IN cord-007636-kfd0wqdx 29 46 IgG IgG NNP cord-007636-kfd0wqdx 29 47 ( ( -LRB- cord-007636-kfd0wqdx 29 48 pre pre JJ cord-007636-kfd0wqdx 29 49 - - VBN cord-007636-kfd0wqdx 29 50 incubated incubate VBN cord-007636-kfd0wqdx 29 51 for for IN cord-007636-kfd0wqdx 29 52 30 30 CD cord-007636-kfd0wqdx 29 53 rain rain NN cord-007636-kfd0wqdx 29 54 with with IN cord-007636-kfd0wqdx 29 55 2 2 CD cord-007636-kfd0wqdx 29 56 % % NN cord-007636-kfd0wqdx 29 57 normal normal JJ cord-007636-kfd0wqdx 29 58 rat rat NN cord-007636-kfd0wqdx 29 59 serum serum NN cord-007636-kfd0wqdx 29 60 to to TO cord-007636-kfd0wqdx 29 61 reduce reduce VB cord-007636-kfd0wqdx 29 62 background background NN cord-007636-kfd0wqdx 29 63 staining staining NN cord-007636-kfd0wqdx 29 64 ) ) -RRB- cord-007636-kfd0wqdx 29 65 ( ( -LRB- cord-007636-kfd0wqdx 29 66 30 30 CD cord-007636-kfd0wqdx 29 67 min min NN cord-007636-kfd0wqdx 29 68 ) ) -RRB- cord-007636-kfd0wqdx 29 69 and and CC cord-007636-kfd0wqdx 29 70 ABC ABC NNP cord-007636-kfd0wqdx 29 71 complex complex NN cord-007636-kfd0wqdx 29 72 ( ( -LRB- cord-007636-kfd0wqdx 29 73 1 1 CD cord-007636-kfd0wqdx 29 74 h h NN cord-007636-kfd0wqdx 29 75 ) ) -RRB- cord-007636-kfd0wqdx 29 76 . . . cord-007636-kfd0wqdx 30 1 The the DT cord-007636-kfd0wqdx 30 2 primary primary JJ cord-007636-kfd0wqdx 30 3 antibodies antibody NNS cord-007636-kfd0wqdx 30 4 were be VBD cord-007636-kfd0wqdx 30 5 diluted dilute VBN cord-007636-kfd0wqdx 30 6 1/10 1/10 CD cord-007636-kfd0wqdx 30 7 except except IN cord-007636-kfd0wqdx 30 8 for for IN cord-007636-kfd0wqdx 30 9 OX18 OX18 NNP cord-007636-kfd0wqdx 30 10 which which WDT cord-007636-kfd0wqdx 30 11 was be VBD cord-007636-kfd0wqdx 30 12 diluted dilute VBN cord-007636-kfd0wqdx 30 13 1/3 1/3 CD cord-007636-kfd0wqdx 30 14 . . . cord-007636-kfd0wqdx 31 1 Specific specific JJ cord-007636-kfd0wqdx 31 2 binding binding NN cord-007636-kfd0wqdx 31 3 was be VBD cord-007636-kfd0wqdx 31 4 visualized visualize VBN cord-007636-kfd0wqdx 31 5 with with IN cord-007636-kfd0wqdx 31 6 a a DT cord-007636-kfd0wqdx 31 7 solution solution NN cord-007636-kfd0wqdx 31 8 containing contain VBG cord-007636-kfd0wqdx 31 9 0.05 0.05 CD cord-007636-kfd0wqdx 31 10 % % NN cord-007636-kfd0wqdx 31 11 diaminobenzidine diaminobenzidine NN cord-007636-kfd0wqdx 31 12 tetrahydrochloride tetrahydrochloride NN cord-007636-kfd0wqdx 31 13 , , , cord-007636-kfd0wqdx 31 14 0.001 0.001 CD cord-007636-kfd0wqdx 31 15 % % NN cord-007636-kfd0wqdx 31 16 hydrogen hydrogen NN cord-007636-kfd0wqdx 31 17 peroxide peroxide NN cord-007636-kfd0wqdx 31 18 , , , cord-007636-kfd0wqdx 31 19 and and CC cord-007636-kfd0wqdx 31 20 0.01 0.01 CD cord-007636-kfd0wqdx 31 21 M m CD cord-007636-kfd0wqdx 31 22 imidazole imidazole NN cord-007636-kfd0wqdx 31 23 for for IN cord-007636-kfd0wqdx 31 24 10 10 CD cord-007636-kfd0wqdx 31 25 min min NN cord-007636-kfd0wqdx 31 26 . . . cord-007636-kfd0wqdx 32 1 P3 P3 NNP cord-007636-kfd0wqdx 32 2 / / SYM cord-007636-kfd0wqdx 32 3 X63 x63 NN cord-007636-kfd0wqdx 32 4 culture culture NN cord-007636-kfd0wqdx 32 5 supernatant supernatant NN cord-007636-kfd0wqdx 32 6 was be VBD cord-007636-kfd0wqdx 32 7 used use VBN cord-007636-kfd0wqdx 32 8 as as IN cord-007636-kfd0wqdx 32 9 a a DT cord-007636-kfd0wqdx 32 10 negative negative JJ cord-007636-kfd0wqdx 32 11 control control NN cord-007636-kfd0wqdx 32 12 . . . cord-007636-kfd0wqdx 33 1 For for IN cord-007636-kfd0wqdx 33 2 GFAP GFAP NNP cord-007636-kfd0wqdx 33 3 staining staining NN cord-007636-kfd0wqdx 33 4 , , , cord-007636-kfd0wqdx 33 5 the the DT cord-007636-kfd0wqdx 33 6 sections section NNS cord-007636-kfd0wqdx 33 7 were be VBD cord-007636-kfd0wqdx 33 8 serially serially RB cord-007636-kfd0wqdx 33 9 incubated incubate VBN cord-007636-kfd0wqdx 33 10 with with IN cord-007636-kfd0wqdx 33 11 2 2 CD cord-007636-kfd0wqdx 33 12 % % NN cord-007636-kfd0wqdx 33 13 normal normal JJ cord-007636-kfd0wqdx 33 14 goat goat NN cord-007636-kfd0wqdx 33 15 serum serum NN cord-007636-kfd0wqdx 33 16 , , , cord-007636-kfd0wqdx 33 17 rabbit rabbit NN cord-007636-kfd0wqdx 33 18 anti anti JJ cord-007636-kfd0wqdx 33 19 - - JJ cord-007636-kfd0wqdx 33 20 cow cow JJ cord-007636-kfd0wqdx 33 21 GFAP GFAP NNP cord-007636-kfd0wqdx 33 22 antibody antibody NN cord-007636-kfd0wqdx 33 23 ( ( -LRB- cord-007636-kfd0wqdx 33 24 1:10,000 1:10,000 CD cord-007636-kfd0wqdx 33 25 ) ) -RRB- cord-007636-kfd0wqdx 33 26 and and CC cord-007636-kfd0wqdx 33 27 biotinylated biotinylated NNP cord-007636-kfd0wqdx 33 28 goat goat NNP cord-007636-kfd0wqdx 33 29 anti anti JJ cord-007636-kfd0wqdx 33 30 - - JJ cord-007636-kfd0wqdx 33 31 rabbit rabbit JJ cord-007636-kfd0wqdx 34 1 IgG. IgG. NNP cord-007636-kfd0wqdx 35 1 The the DT cord-007636-kfd0wqdx 35 2 remainder remainder NN cord-007636-kfd0wqdx 35 3 of of IN cord-007636-kfd0wqdx 35 4 the the DT cord-007636-kfd0wqdx 35 5 procedure procedure NN cord-007636-kfd0wqdx 35 6 was be VBD cord-007636-kfd0wqdx 35 7 unchanged unchanged JJ cord-007636-kfd0wqdx 35 8 from from IN cord-007636-kfd0wqdx 35 9 the the DT cord-007636-kfd0wqdx 35 10 one one NN cord-007636-kfd0wqdx 35 11 outlined outline VBN cord-007636-kfd0wqdx 35 12 above above RB cord-007636-kfd0wqdx 35 13 . . . cord-007636-kfd0wqdx 36 1 Normal normal JJ cord-007636-kfd0wqdx 36 2 rabbit rabbit NN cord-007636-kfd0wqdx 36 3 serum serum NN cord-007636-kfd0wqdx 36 4 was be VBD cord-007636-kfd0wqdx 36 5 used use VBN cord-007636-kfd0wqdx 36 6 as as IN cord-007636-kfd0wqdx 36 7 a a DT cord-007636-kfd0wqdx 36 8 negative negative JJ cord-007636-kfd0wqdx 36 9 control control NN cord-007636-kfd0wqdx 36 10 . . . cord-007636-kfd0wqdx 37 1 Irradiation irradiation NN cord-007636-kfd0wqdx 37 2 of of IN cord-007636-kfd0wqdx 37 3 tumor tumor NN cord-007636-kfd0wqdx 37 4 - - HYPH cord-007636-kfd0wqdx 37 5 free free JJ cord-007636-kfd0wqdx 37 6 brain brain NN cord-007636-kfd0wqdx 37 7 . . . cord-007636-kfd0wqdx 38 1 The the DT cord-007636-kfd0wqdx 38 2 posterior posterior JJ cord-007636-kfd0wqdx 38 3 half half NN cord-007636-kfd0wqdx 38 4 of of IN cord-007636-kfd0wqdx 38 5 the the DT cord-007636-kfd0wqdx 38 6 brains brain NNS cord-007636-kfd0wqdx 38 7 of of IN cord-007636-kfd0wqdx 38 8 12 12 CD cord-007636-kfd0wqdx 38 9 anesthetized anesthetize VBN cord-007636-kfd0wqdx 38 10 rats rat NNS cord-007636-kfd0wqdx 38 11 was be VBD cord-007636-kfd0wqdx 38 12 irradiated irradiate VBN cord-007636-kfd0wqdx 38 13 with with IN cord-007636-kfd0wqdx 38 14 a a DT cord-007636-kfd0wqdx 38 15 single single JJ cord-007636-kfd0wqdx 38 16 dose dose NN cord-007636-kfd0wqdx 38 17 of of IN cord-007636-kfd0wqdx 38 18 1200 1200 CD cord-007636-kfd0wqdx 38 19 cGy cGy NNS cord-007636-kfd0wqdx 38 20 using use VBG cord-007636-kfd0wqdx 38 21 a a DT cord-007636-kfd0wqdx 38 22 GE GE NNP cord-007636-kfd0wqdx 38 23 Maximar Maximar NNP cord-007636-kfd0wqdx 38 24 XRay XRay NNP cord-007636-kfd0wqdx 38 25 generator generator NN cord-007636-kfd0wqdx 38 26 . . . cord-007636-kfd0wqdx 39 1 This this DT cord-007636-kfd0wqdx 39 2 dose dose NN cord-007636-kfd0wqdx 39 3 was be VBD cord-007636-kfd0wqdx 39 4 biologically biologically RB cord-007636-kfd0wqdx 39 5 equivalent equivalent JJ cord-007636-kfd0wqdx 39 6 to to IN cord-007636-kfd0wqdx 39 7 the the DT cord-007636-kfd0wqdx 39 8 high high JJ cord-007636-kfd0wqdx 39 9 doses dose NNS cord-007636-kfd0wqdx 39 10 of of IN cord-007636-kfd0wqdx 39 11 fractionated fractionate VBN cord-007636-kfd0wqdx 39 12 radiation radiation NN cord-007636-kfd0wqdx 39 13 used use VBN cord-007636-kfd0wqdx 39 14 clinically clinically RB cord-007636-kfd0wqdx 39 15 in in IN cord-007636-kfd0wqdx 39 16 the the DT cord-007636-kfd0wqdx 39 17 treatment treatment NN cord-007636-kfd0wqdx 39 18 of of IN cord-007636-kfd0wqdx 39 19 patients patient NNS cord-007636-kfd0wqdx 39 20 with with IN cord-007636-kfd0wqdx 39 21 malignant malignant JJ cord-007636-kfd0wqdx 39 22 gliomas glioma NNS cord-007636-kfd0wqdx 39 23 ( ( -LRB- cord-007636-kfd0wqdx 39 24 Ellis Ellis NNP cord-007636-kfd0wqdx 39 25 , , , cord-007636-kfd0wqdx 39 26 1971 1971 CD cord-007636-kfd0wqdx 39 27 ; ; : cord-007636-kfd0wqdx 39 28 Kramer Kramer NNP cord-007636-kfd0wqdx 39 29 et et NNP cord-007636-kfd0wqdx 39 30 al al NNP cord-007636-kfd0wqdx 39 31 . . NNP cord-007636-kfd0wqdx 39 32 , , , cord-007636-kfd0wqdx 39 33 1977 1977 CD cord-007636-kfd0wqdx 39 34 ; ; . cord-007636-kfd0wqdx 40 1 Henderson Henderson NNP cord-007636-kfd0wqdx 40 2 et et NNP cord-007636-kfd0wqdx 40 3 al al NNP cord-007636-kfd0wqdx 40 4 . . NNP cord-007636-kfd0wqdx 40 5 , , , cord-007636-kfd0wqdx 40 6 1981 1981 CD cord-007636-kfd0wqdx 40 7 ) ) -RRB- cord-007636-kfd0wqdx 40 8 . . . cord-007636-kfd0wqdx 41 1 Lead lead VB cord-007636-kfd0wqdx 41 2 foil foil NN cord-007636-kfd0wqdx 41 3 blocks block NNS cord-007636-kfd0wqdx 41 4 shielded shield VBD cord-007636-kfd0wqdx 41 5 the the DT cord-007636-kfd0wqdx 41 6 anterior anterior JJ cord-007636-kfd0wqdx 41 7 half half NN cord-007636-kfd0wqdx 41 8 of of IN cord-007636-kfd0wqdx 41 9 the the DT cord-007636-kfd0wqdx 41 10 brain brain NN cord-007636-kfd0wqdx 41 11 , , , cord-007636-kfd0wqdx 41 12 which which WDT cord-007636-kfd0wqdx 41 13 acted act VBD cord-007636-kfd0wqdx 41 14 as as IN cord-007636-kfd0wqdx 41 15 an an DT cord-007636-kfd0wqdx 41 16 internal internal JJ cord-007636-kfd0wqdx 41 17 control control NN cord-007636-kfd0wqdx 41 18 . . . cord-007636-kfd0wqdx 42 1 Two two CD cord-007636-kfd0wqdx 42 2 unirradiated unirradiated JJ cord-007636-kfd0wqdx 42 3 rats rat NNS cord-007636-kfd0wqdx 42 4 served serve VBD cord-007636-kfd0wqdx 42 5 as as IN cord-007636-kfd0wqdx 42 6 additional additional JJ cord-007636-kfd0wqdx 42 7 controls control NNS cord-007636-kfd0wqdx 42 8 . . . cord-007636-kfd0wqdx 43 1 The the DT cord-007636-kfd0wqdx 43 2 animals animal NNS cord-007636-kfd0wqdx 43 3 were be VBD cord-007636-kfd0wqdx 43 4 sacrificed sacrifice VBN cord-007636-kfd0wqdx 43 5 on on IN cord-007636-kfd0wqdx 43 6 days day NNS cord-007636-kfd0wqdx 43 7 0 0 NFP cord-007636-kfd0wqdx 43 8 ( ( -LRB- cord-007636-kfd0wqdx 43 9 immediately immediately RB cord-007636-kfd0wqdx 43 10 after after IN cord-007636-kfd0wqdx 43 11 irradiation irradiation NN cord-007636-kfd0wqdx 43 12 ) ) -RRB- cord-007636-kfd0wqdx 43 13 , , , cord-007636-kfd0wqdx 43 14 1 1 CD cord-007636-kfd0wqdx 43 15 , , , cord-007636-kfd0wqdx 43 16 2 2 CD cord-007636-kfd0wqdx 43 17 and and CC cord-007636-kfd0wqdx 43 18 5 5 CD cord-007636-kfd0wqdx 43 19 and and CC cord-007636-kfd0wqdx 43 20 weeks week NNS cord-007636-kfd0wqdx 43 21 1 1 CD cord-007636-kfd0wqdx 43 22 , , , cord-007636-kfd0wqdx 43 23 2 2 CD cord-007636-kfd0wqdx 43 24 , , , cord-007636-kfd0wqdx 43 25 3 3 CD cord-007636-kfd0wqdx 43 26 , , , cord-007636-kfd0wqdx 43 27 4 4 CD cord-007636-kfd0wqdx 43 28 , , , cord-007636-kfd0wqdx 43 29 5 5 CD cord-007636-kfd0wqdx 43 30 , , , cord-007636-kfd0wqdx 43 31 7 7 CD cord-007636-kfd0wqdx 43 32 , , , cord-007636-kfd0wqdx 43 33 10 10 CD cord-007636-kfd0wqdx 43 34 and and CC cord-007636-kfd0wqdx 43 35 16 16 CD cord-007636-kfd0wqdx 43 36 . . . cord-007636-kfd0wqdx 44 1 6 6 CD cord-007636-kfd0wqdx 44 2 /~m /~m NN cord-007636-kfd0wqdx 44 3 coronal coronal JJ cord-007636-kfd0wqdx 44 4 frozen frozen JJ cord-007636-kfd0wqdx 44 5 sections section NNS cord-007636-kfd0wqdx 44 6 of of IN cord-007636-kfd0wqdx 44 7 the the DT cord-007636-kfd0wqdx 44 8 brains brain NNS cord-007636-kfd0wqdx 44 9 were be VBD cord-007636-kfd0wqdx 44 10 obtained obtain VBN cord-007636-kfd0wqdx 44 11 through through IN cord-007636-kfd0wqdx 44 12 the the DT cord-007636-kfd0wqdx 44 13 irradiated irradiate VBN cord-007636-kfd0wqdx 44 14 parietal parietal JJ cord-007636-kfd0wqdx 44 15 lobes lobe NNS cord-007636-kfd0wqdx 44 16 and and CC cord-007636-kfd0wqdx 44 17 the the DT cord-007636-kfd0wqdx 44 18 shielded shielded JJ cord-007636-kfd0wqdx 44 19 frontal frontal JJ cord-007636-kfd0wqdx 44 20 lobes lobe NNS cord-007636-kfd0wqdx 44 21 and and CC cord-007636-kfd0wqdx 44 22 examined examine VBN cord-007636-kfd0wqdx 44 23 for for IN cord-007636-kfd0wqdx 44 24 histologic histologic JJ cord-007636-kfd0wqdx 44 25 changes change NNS cord-007636-kfd0wqdx 44 26 ( ( -LRB- cord-007636-kfd0wqdx 44 27 hematoxylin hematoxylin NNP cord-007636-kfd0wqdx 44 28 and and CC cord-007636-kfd0wqdx 44 29 eosin eosin NNPS cord-007636-kfd0wqdx 44 30 ; ; : cord-007636-kfd0wqdx 44 31 H H NNP cord-007636-kfd0wqdx 44 32 & & CC cord-007636-kfd0wqdx 44 33 E E NNP cord-007636-kfd0wqdx 44 34 ) ) -RRB- cord-007636-kfd0wqdx 44 35 and and CC cord-007636-kfd0wqdx 44 36 demyelination demyelination NN cord-007636-kfd0wqdx 44 37 ( ( -LRB- cord-007636-kfd0wqdx 44 38 Luxol Luxol NNP cord-007636-kfd0wqdx 44 39 Fast Fast NNP cord-007636-kfd0wqdx 44 40 Blue Blue NNP cord-007636-kfd0wqdx 44 41 ) ) -RRB- cord-007636-kfd0wqdx 44 42 , , , cord-007636-kfd0wqdx 44 43 and and CC cord-007636-kfd0wqdx 44 44 immunocytochemically immunocytochemically RB cord-007636-kfd0wqdx 44 45 . . . cord-007636-kfd0wqdx 45 1 Sections section NNS cord-007636-kfd0wqdx 45 2 from from IN cord-007636-kfd0wqdx 45 3 the the DT cord-007636-kfd0wqdx 45 4 corresponding corresponding JJ cord-007636-kfd0wqdx 45 5 areas area NNS cord-007636-kfd0wqdx 45 6 of of IN cord-007636-kfd0wqdx 45 7 the the DT cord-007636-kfd0wqdx 45 8 brains brain NNS cord-007636-kfd0wqdx 45 9 of of IN cord-007636-kfd0wqdx 45 10 the the DT cord-007636-kfd0wqdx 45 11 unirradiated unirradiated JJ cord-007636-kfd0wqdx 45 12 rats rat NNS cord-007636-kfd0wqdx 45 13 served serve VBD cord-007636-kfd0wqdx 45 14 as as IN cord-007636-kfd0wqdx 45 15 additional additional JJ cord-007636-kfd0wqdx 45 16 controls control NNS cord-007636-kfd0wqdx 45 17 . . . cord-007636-kfd0wqdx 46 1 Normal normal JJ cord-007636-kfd0wqdx 46 2 lymph lymph NN cord-007636-kfd0wqdx 46 3 nodes node NNS cord-007636-kfd0wqdx 46 4 and and CC cord-007636-kfd0wqdx 46 5 brains brain NNS cord-007636-kfd0wqdx 46 6 from from IN cord-007636-kfd0wqdx 46 7 two two CD cord-007636-kfd0wqdx 46 8 rats rat NNS cord-007636-kfd0wqdx 46 9 that that WDT cord-007636-kfd0wqdx 46 10 had have VBD cord-007636-kfd0wqdx 46 11 20,000 20,000 CD cord-007636-kfd0wqdx 46 12 units unit NNS cord-007636-kfd0wqdx 46 13 of of IN cord-007636-kfd0wqdx 46 14 recombinant recombinant JJ cord-007636-kfd0wqdx 46 15 T t NN cord-007636-kfd0wqdx 46 16 - - HYPH cord-007636-kfd0wqdx 46 17 interferon interferon NNP cord-007636-kfd0wqdx 46 18 ( ( -LRB- cord-007636-kfd0wqdx 46 19 IFN IFN NNP cord-007636-kfd0wqdx 46 20 - - HYPH cord-007636-kfd0wqdx 46 21 T T NNP cord-007636-kfd0wqdx 46 22 ) ) -RRB- cord-007636-kfd0wqdx 46 23 ( ( -LRB- cord-007636-kfd0wqdx 46 24 Biogen Biogen NNP cord-007636-kfd0wqdx 46 25 Biologicals Biologicals NNPS cord-007636-kfd0wqdx 46 26 ) ) -RRB- cord-007636-kfd0wqdx 46 27 injected inject VBD cord-007636-kfd0wqdx 46 28 into into IN cord-007636-kfd0wqdx 46 29 the the DT cord-007636-kfd0wqdx 46 30 parietal parietal JJ cord-007636-kfd0wqdx 46 31 lobes lobe NNS cord-007636-kfd0wqdx 46 32 3 3 CD cord-007636-kfd0wqdx 46 33 days day NNS cord-007636-kfd0wqdx 46 34 prior prior RB cord-007636-kfd0wqdx 46 35 to to IN cord-007636-kfd0wqdx 46 36 being be VBG cord-007636-kfd0wqdx 46 37 sacrificed sacrifice VBN cord-007636-kfd0wqdx 46 38 served serve VBN cord-007636-kfd0wqdx 46 39 as as IN cord-007636-kfd0wqdx 46 40 positive positive JJ cord-007636-kfd0wqdx 46 41 controls control NNS cord-007636-kfd0wqdx 46 42 . . . cord-007636-kfd0wqdx 47 1 Irradiation irradiation NN cord-007636-kfd0wqdx 47 2 of of IN cord-007636-kfd0wqdx 47 3 tumor tumor NN cord-007636-kfd0wqdx 47 4 - - HYPH cord-007636-kfd0wqdx 47 5 bearing bear VBG cord-007636-kfd0wqdx 47 6 animals animal NNS cord-007636-kfd0wqdx 47 7 . . . cord-007636-kfd0wqdx 48 1 The the DT cord-007636-kfd0wqdx 48 2 9L 9l CD cord-007636-kfd0wqdx 48 3 gliosarcoma gliosarcoma NNP cord-007636-kfd0wqdx 48 4 cell cell NN cord-007636-kfd0wqdx 48 5 line line NN cord-007636-kfd0wqdx 48 6 was be VBD cord-007636-kfd0wqdx 48 7 originally originally RB cord-007636-kfd0wqdx 48 8 derived derive VBN cord-007636-kfd0wqdx 48 9 from from IN cord-007636-kfd0wqdx 48 10 tumors tumor NNS cord-007636-kfd0wqdx 48 11 induced induce VBN cord-007636-kfd0wqdx 48 12 in in IN cord-007636-kfd0wqdx 48 13 CDF CDF NNP cord-007636-kfd0wqdx 48 14 rats rat NNS cord-007636-kfd0wqdx 48 15 by by IN cord-007636-kfd0wqdx 48 16 weekly weekly JJ cord-007636-kfd0wqdx 48 17 intravenous intravenous JJ cord-007636-kfd0wqdx 48 18 injections injection NNS cord-007636-kfd0wqdx 48 19 of of IN cord-007636-kfd0wqdx 48 20 N N NNP cord-007636-kfd0wqdx 48 21 - - HYPH cord-007636-kfd0wqdx 48 22 nitrosomethylurea nitrosomethylurea NNP cord-007636-kfd0wqdx 49 1 ( ( -LRB- cord-007636-kfd0wqdx 49 2 Schmidek Schmidek NNP cord-007636-kfd0wqdx 49 3 et et NNP cord-007636-kfd0wqdx 49 4 al al NNP cord-007636-kfd0wqdx 49 5 . . NNP cord-007636-kfd0wqdx 49 6 , , , cord-007636-kfd0wqdx 49 7 1971 1971 CD cord-007636-kfd0wqdx 49 8 ) ) -RRB- cord-007636-kfd0wqdx 49 9 . . . cord-007636-kfd0wqdx 50 1 2 2 LS cord-007636-kfd0wqdx 51 1 x x SYM cord-007636-kfd0wqdx 51 2 10 10 CD cord-007636-kfd0wqdx 51 3 4 4 CD cord-007636-kfd0wqdx 51 4 9L 9l CD cord-007636-kfd0wqdx 51 5 cells cell NNS cord-007636-kfd0wqdx 51 6 were be VBD cord-007636-kfd0wqdx 51 7 stereotactically stereotactically RB cord-007636-kfd0wqdx 51 8 implanted implant VBN cord-007636-kfd0wqdx 51 9 into into IN cord-007636-kfd0wqdx 51 10 the the DT cord-007636-kfd0wqdx 51 11 right right JJ cord-007636-kfd0wqdx 51 12 caudate caudate NNP cord-007636-kfd0wqdx 51 13 nucleus nucleus NN cord-007636-kfd0wqdx 51 14 of of IN cord-007636-kfd0wqdx 51 15 CDF CDF NNP cord-007636-kfd0wqdx 51 16 rats rat NNS cord-007636-kfd0wqdx 51 17 using use VBG cord-007636-kfd0wqdx 51 18 a a DT cord-007636-kfd0wqdx 51 19 modification modification NN cord-007636-kfd0wqdx 51 20 of of IN cord-007636-kfd0wqdx 51 21 the the DT cord-007636-kfd0wqdx 51 22 method method NN cord-007636-kfd0wqdx 51 23 of of IN cord-007636-kfd0wqdx 51 24 Kobayashi Kobayashi NNP cord-007636-kfd0wqdx 51 25 ( ( -LRB- cord-007636-kfd0wqdx 51 26 Kobayashi Kobayashi NNP cord-007636-kfd0wqdx 51 27 et et FW cord-007636-kfd0wqdx 51 28 al al NNP cord-007636-kfd0wqdx 51 29 . . NNP cord-007636-kfd0wqdx 51 30 , , , cord-007636-kfd0wqdx 51 31 1980 1980 CD cord-007636-kfd0wqdx 51 32 ) ) -RRB- cord-007636-kfd0wqdx 51 33 . . . cord-007636-kfd0wqdx 52 1 On on IN cord-007636-kfd0wqdx 52 2 day day NN cord-007636-kfd0wqdx 52 3 12 12 CD cord-007636-kfd0wqdx 52 4 after after IN cord-007636-kfd0wqdx 52 5 implantation implantation NN cord-007636-kfd0wqdx 52 6 half half PDT cord-007636-kfd0wqdx 52 7 the the DT cord-007636-kfd0wqdx 52 8 animals animal NNS cord-007636-kfd0wqdx 52 9 were be VBD cord-007636-kfd0wqdx 52 10 anesthetized anesthetize VBN cord-007636-kfd0wqdx 52 11 and and CC cord-007636-kfd0wqdx 52 12 the the DT cord-007636-kfd0wqdx 52 13 whole whole JJ cord-007636-kfd0wqdx 52 14 brain brain NN cord-007636-kfd0wqdx 52 15 irradiated irradiate VBN cord-007636-kfd0wqdx 52 16 with with IN cord-007636-kfd0wqdx 52 17 a a DT cord-007636-kfd0wqdx 52 18 single single JJ cord-007636-kfd0wqdx 52 19 dose dose NN cord-007636-kfd0wqdx 52 20 of of IN cord-007636-kfd0wqdx 52 21 1200 1200 CD cord-007636-kfd0wqdx 52 22 cGy cGy NNS cord-007636-kfd0wqdx 52 23 . . . cord-007636-kfd0wqdx 52 24 1 1 CD cord-007636-kfd0wqdx 52 25 - - SYM cord-007636-kfd0wqdx 52 26 2 2 CD cord-007636-kfd0wqdx 52 27 irradiated irradiate VBN cord-007636-kfd0wqdx 52 28 and and CC cord-007636-kfd0wqdx 52 29 1 1 CD cord-007636-kfd0wqdx 52 30 - - SYM cord-007636-kfd0wqdx 52 31 2 2 CD cord-007636-kfd0wqdx 52 32 non non JJ cord-007636-kfd0wqdx 52 33 - - JJ cord-007636-kfd0wqdx 52 34 irradiated irradiate VBN cord-007636-kfd0wqdx 52 35 rats rat NNS cord-007636-kfd0wqdx 52 36 were be VBD cord-007636-kfd0wqdx 52 37 then then RB cord-007636-kfd0wqdx 52 38 sacrificed sacrifice VBN cord-007636-kfd0wqdx 52 39 on on IN cord-007636-kfd0wqdx 52 40 days day NNS cord-007636-kfd0wqdx 52 41 0 0 CD cord-007636-kfd0wqdx 52 42 , , , cord-007636-kfd0wqdx 52 43 1 1 CD cord-007636-kfd0wqdx 52 44 , , , cord-007636-kfd0wqdx 52 45 2 2 CD cord-007636-kfd0wqdx 52 46 , , , cord-007636-kfd0wqdx 52 47 3 3 CD cord-007636-kfd0wqdx 52 48 , , , cord-007636-kfd0wqdx 52 49 5 5 CD cord-007636-kfd0wqdx 52 50 , , , cord-007636-kfd0wqdx 52 51 7 7 CD cord-007636-kfd0wqdx 52 52 , , , cord-007636-kfd0wqdx 52 53 10 10 CD cord-007636-kfd0wqdx 52 54 , , , cord-007636-kfd0wqdx 52 55 14 14 CD cord-007636-kfd0wqdx 52 56 and and CC cord-007636-kfd0wqdx 52 57 21 21 CD cord-007636-kfd0wqdx 52 58 . . . cord-007636-kfd0wqdx 53 1 Although although IN cord-007636-kfd0wqdx 53 2 an an DT cord-007636-kfd0wqdx 53 3 attempt attempt NN cord-007636-kfd0wqdx 53 4 was be VBD cord-007636-kfd0wqdx 53 5 made make VBN cord-007636-kfd0wqdx 53 6 to to TO cord-007636-kfd0wqdx 53 7 match match VB cord-007636-kfd0wqdx 53 8 irradiated irradiate VBN cord-007636-kfd0wqdx 53 9 with with IN cord-007636-kfd0wqdx 53 10 non non JJ cord-007636-kfd0wqdx 53 11 - - JJ cord-007636-kfd0wqdx 53 12 irradiated irradiated JJ cord-007636-kfd0wqdx 53 13 controls control NNS cord-007636-kfd0wqdx 53 14 as as RB cord-007636-kfd0wqdx 53 15 closely closely RB cord-007636-kfd0wqdx 53 16 as as IN cord-007636-kfd0wqdx 53 17 possible possible JJ cord-007636-kfd0wqdx 53 18 , , , cord-007636-kfd0wqdx 53 19 none none NN cord-007636-kfd0wqdx 53 20 of of IN cord-007636-kfd0wqdx 53 21 the the DT cord-007636-kfd0wqdx 53 22 nonirradiated nonirradiate VBN cord-007636-kfd0wqdx 53 23 tumor tumor NN cord-007636-kfd0wqdx 53 24 - - HYPH cord-007636-kfd0wqdx 53 25 bearing bear VBG cord-007636-kfd0wqdx 53 26 animals animal NNS cord-007636-kfd0wqdx 53 27 survived survive VBD cord-007636-kfd0wqdx 53 28 beyond beyond IN cord-007636-kfd0wqdx 53 29 day day NN cord-007636-kfd0wqdx 53 30 14 14 CD cord-007636-kfd0wqdx 53 31 ( ( -LRB- cord-007636-kfd0wqdx 53 32 26 26 CD cord-007636-kfd0wqdx 53 33 days day NNS cord-007636-kfd0wqdx 53 34 after after IN cord-007636-kfd0wqdx 53 35 implantation implantation NN cord-007636-kfd0wqdx 53 36 ) ) -RRB- cord-007636-kfd0wqdx 53 37 . . . cord-007636-kfd0wqdx 54 1 Coronal coronal JJ cord-007636-kfd0wqdx 54 2 frozen frozen JJ cord-007636-kfd0wqdx 54 3 sections section NNS cord-007636-kfd0wqdx 54 4 were be VBD cord-007636-kfd0wqdx 54 5 obtained obtain VBN cord-007636-kfd0wqdx 54 6 through through IN cord-007636-kfd0wqdx 54 7 the the DT cord-007636-kfd0wqdx 54 8 center center NN cord-007636-kfd0wqdx 54 9 of of IN cord-007636-kfd0wqdx 54 10 the the DT cord-007636-kfd0wqdx 54 11 tumors tumor NNS cord-007636-kfd0wqdx 54 12 and and CC cord-007636-kfd0wqdx 54 13 assayed assay VBN cord-007636-kfd0wqdx 54 14 immunocytochemically immunocytochemically RB cord-007636-kfd0wqdx 54 15 . . . cord-007636-kfd0wqdx 55 1 With with IN cord-007636-kfd0wqdx 55 2 each each DT cord-007636-kfd0wqdx 55 3 antibody antibody NN cord-007636-kfd0wqdx 55 4 , , , cord-007636-kfd0wqdx 55 5 the the DT cord-007636-kfd0wqdx 55 6 percentages percentage NNS cord-007636-kfd0wqdx 55 7 of of IN cord-007636-kfd0wqdx 55 8 positively positively RB cord-007636-kfd0wqdx 55 9 staining stain VBG cord-007636-kfd0wqdx 55 10 cells cell NNS cord-007636-kfd0wqdx 55 11 / / SYM cord-007636-kfd0wqdx 55 12 total total JJ cord-007636-kfd0wqdx 55 13 number number NN cord-007636-kfd0wqdx 55 14 of of IN cord-007636-kfd0wqdx 55 15 all all DT cord-007636-kfd0wqdx 55 16 cells cell NNS cord-007636-kfd0wqdx 55 17 from from IN cord-007636-kfd0wqdx 55 18 six six CD cord-007636-kfd0wqdx 55 19 random random JJ cord-007636-kfd0wqdx 55 20 high high RB cord-007636-kfd0wqdx 55 21 - - HYPH cord-007636-kfd0wqdx 55 22 powered power VBN cord-007636-kfd0wqdx 55 23 fields field NNS cord-007636-kfd0wqdx 55 24 within within IN cord-007636-kfd0wqdx 55 25 the the DT cord-007636-kfd0wqdx 55 26 tumor tumor NN cord-007636-kfd0wqdx 55 27 ( ( -LRB- cord-007636-kfd0wqdx 55 28 minimum minimum NN cord-007636-kfd0wqdx 55 29 of of IN cord-007636-kfd0wqdx 55 30 900 900 CD cord-007636-kfd0wqdx 55 31 cells cell NNS cord-007636-kfd0wqdx 55 32 ) ) -RRB- cord-007636-kfd0wqdx 55 33 were be VBD cord-007636-kfd0wqdx 55 34 obtained obtain VBN cord-007636-kfd0wqdx 55 35 and and CC cord-007636-kfd0wqdx 55 36 the the DT cord-007636-kfd0wqdx 55 37 average average NN cord-007636-kfd0wqdx 55 38 determined determine VBN cord-007636-kfd0wqdx 55 39 ( ( -LRB- cord-007636-kfd0wqdx 55 40 Whelan Whelan NNP cord-007636-kfd0wqdx 55 41 et et NNP cord-007636-kfd0wqdx 55 42 al al NNP cord-007636-kfd0wqdx 55 43 . . NNP cord-007636-kfd0wqdx 55 44 , , , cord-007636-kfd0wqdx 55 45 1985 1985 CD cord-007636-kfd0wqdx 55 46 ) ) -RRB- cord-007636-kfd0wqdx 55 47 . . . cord-007636-kfd0wqdx 55 48 _SP cord-007636-kfd0wqdx 56 1 In in IN cord-007636-kfd0wqdx 56 2 the the DT cord-007636-kfd0wqdx 56 3 normal normal JJ cord-007636-kfd0wqdx 56 4 rat rat NN cord-007636-kfd0wqdx 56 5 brain brain NN cord-007636-kfd0wqdx 56 6 , , , cord-007636-kfd0wqdx 56 7 irradiation irradiation NN cord-007636-kfd0wqdx 56 8 did do VBD cord-007636-kfd0wqdx 56 9 not not RB cord-007636-kfd0wqdx 56 10 produce produce VB cord-007636-kfd0wqdx 56 11 significant significant JJ cord-007636-kfd0wqdx 56 12 histologic histologic JJ cord-007636-kfd0wqdx 56 13 changes change NNS cord-007636-kfd0wqdx 56 14 , , , cord-007636-kfd0wqdx 56 15 demyelination demyelination NN cord-007636-kfd0wqdx 56 16 or or CC cord-007636-kfd0wqdx 56 17 gliosis gliosis NN cord-007636-kfd0wqdx 56 18 within within IN cord-007636-kfd0wqdx 56 19 the the DT cord-007636-kfd0wqdx 56 20 time time NN cord-007636-kfd0wqdx 56 21 period period NN cord-007636-kfd0wqdx 56 22 studied study VBD cord-007636-kfd0wqdx 56 23 . . . cord-007636-kfd0wqdx 57 1 The the DT cord-007636-kfd0wqdx 57 2 monoclonal monoclonal JJ cord-007636-kfd0wqdx 57 3 antibodies antibody NNS cord-007636-kfd0wqdx 57 4 to to TO cord-007636-kfd0wqdx 57 5 class class NN cord-007636-kfd0wqdx 57 6 I -PRON- PRP cord-007636-kfd0wqdx 57 7 and and CC cord-007636-kfd0wqdx 57 8 I -PRON- PRP cord-007636-kfd0wqdx 57 9 ! ! . cord-007636-kfd0wqdx 58 1 MHC MHC NNP cord-007636-kfd0wqdx 58 2 antigens antigen NNS cord-007636-kfd0wqdx 58 3 produced produce VBD cord-007636-kfd0wqdx 58 4 dense dense JJ cord-007636-kfd0wqdx 58 5 staining staining NN cord-007636-kfd0wqdx 58 6 of of IN cord-007636-kfd0wqdx 58 7 the the DT cord-007636-kfd0wqdx 58 8 lymph lymph NN cord-007636-kfd0wqdx 58 9 node node NN cord-007636-kfd0wqdx 58 10 controls control NNS cord-007636-kfd0wqdx 58 11 , , , cord-007636-kfd0wqdx 58 12 and and CC cord-007636-kfd0wqdx 58 13 of of IN cord-007636-kfd0wqdx 58 14 dendritic dendritic JJ cord-007636-kfd0wqdx 58 15 cells cell NNS cord-007636-kfd0wqdx 58 16 in in IN cord-007636-kfd0wqdx 58 17 control control NN cord-007636-kfd0wqdx 58 18 brains brain NNS cord-007636-kfd0wqdx 58 19 that that WDT cord-007636-kfd0wqdx 58 20 had have VBD cord-007636-kfd0wqdx 58 21 been be VBN cord-007636-kfd0wqdx 58 22 treated treat VBN cord-007636-kfd0wqdx 58 23 with with IN cord-007636-kfd0wqdx 58 24 IFN-7 IFN-7 NNP cord-007636-kfd0wqdx 58 25 . . . cord-007636-kfd0wqdx 59 1 No no DT cord-007636-kfd0wqdx 59 2 differences difference NNS cord-007636-kfd0wqdx 59 3 were be VBD cord-007636-kfd0wqdx 59 4 detected detect VBN cord-007636-kfd0wqdx 59 5 in in IN cord-007636-kfd0wqdx 59 6 the the DT cord-007636-kfd0wqdx 59 7 staining stain VBG cord-007636-kfd0wqdx 59 8 patterns pattern NNS cord-007636-kfd0wqdx 59 9 in in IN cord-007636-kfd0wqdx 59 10 irradiated irradiate VBN cord-007636-kfd0wqdx 59 11 brain brain NN cord-007636-kfd0wqdx 59 12 areas area NNS cord-007636-kfd0wqdx 59 13 compared compare VBN cord-007636-kfd0wqdx 59 14 to to IN cord-007636-kfd0wqdx 59 15 unirradiated unirradiated JJ cord-007636-kfd0wqdx 59 16 areas area NNS cord-007636-kfd0wqdx 59 17 or or CC cord-007636-kfd0wqdx 59 18 normal normal JJ cord-007636-kfd0wqdx 59 19 brains brain NNS cord-007636-kfd0wqdx 59 20 : : : cord-007636-kfd0wqdx 59 21 class class NN cord-007636-kfd0wqdx 60 1 I -PRON- PRP cord-007636-kfd0wqdx 60 2 was be VBD cord-007636-kfd0wqdx 60 3 restricted restrict VBN cord-007636-kfd0wqdx 60 4 to to IN cord-007636-kfd0wqdx 60 5 blood blood NN cord-007636-kfd0wqdx 60 6 vessel vessel NN cord-007636-kfd0wqdx 60 7 walls wall NNS cord-007636-kfd0wqdx 60 8 , , , cord-007636-kfd0wqdx 60 9 and and CC cord-007636-kfd0wqdx 60 10 class class NN cord-007636-kfd0wqdx 60 11 II II NNP cord-007636-kfd0wqdx 60 12 to to IN cord-007636-kfd0wqdx 60 13 occasional occasional JJ cord-007636-kfd0wqdx 60 14 cells cell NNS cord-007636-kfd0wqdx 60 15 associated associate VBN cord-007636-kfd0wqdx 60 16 with with IN cord-007636-kfd0wqdx 60 17 the the DT cord-007636-kfd0wqdx 60 18 leptomeninges leptomeninge NNS cord-007636-kfd0wqdx 60 19 , , , cord-007636-kfd0wqdx 60 20 choroid choroid JJ cord-007636-kfd0wqdx 60 21 plexus plexus NN cord-007636-kfd0wqdx 60 22 and and CC cord-007636-kfd0wqdx 60 23 blood blood NN cord-007636-kfd0wqdx 60 24 vessels vessel NNS cord-007636-kfd0wqdx 60 25 , , , cord-007636-kfd0wqdx 60 26 and and CC cord-007636-kfd0wqdx 60 27 rare rare JJ cord-007636-kfd0wqdx 60 28 dendritic dendritic JJ cord-007636-kfd0wqdx 60 29 cells cell NNS cord-007636-kfd0wqdx 60 30 . . . cord-007636-kfd0wqdx 61 1 The the DT cord-007636-kfd0wqdx 61 2 antibody antibody NN cord-007636-kfd0wqdx 61 3 to to IN cord-007636-kfd0wqdx 61 4 LCA LCA NNP cord-007636-kfd0wqdx 61 5 ( ( -LRB- cord-007636-kfd0wqdx 61 6 OX1 OX1 NNP cord-007636-kfd0wqdx 61 7 ) ) -RRB- cord-007636-kfd0wqdx 61 8 produced produce VBD cord-007636-kfd0wqdx 61 9 strong strong JJ cord-007636-kfd0wqdx 61 10 staining staining NN cord-007636-kfd0wqdx 61 11 in in IN cord-007636-kfd0wqdx 61 12 lymphoid lymphoid JJ cord-007636-kfd0wqdx 61 13 controls control NNS cord-007636-kfd0wqdx 61 14 , , , cord-007636-kfd0wqdx 61 15 but but CC cord-007636-kfd0wqdx 61 16 stained stain VBN cord-007636-kfd0wqdx 61 17 only only JJ cord-007636-kfd0wqdx 61 18 occasional occasional JJ cord-007636-kfd0wqdx 61 19 inflammatory inflammatory JJ cord-007636-kfd0wqdx 61 20 cells cell NNS cord-007636-kfd0wqdx 61 21 in in IN cord-007636-kfd0wqdx 61 22 the the DT cord-007636-kfd0wqdx 61 23 leptomeninges leptomeninge NNS cord-007636-kfd0wqdx 61 24 in in IN cord-007636-kfd0wqdx 61 25 both both CC cord-007636-kfd0wqdx 61 26 irradiated irradiate VBN cord-007636-kfd0wqdx 61 27 and and CC cord-007636-kfd0wqdx 61 28 unirradiated unirradiated JJ cord-007636-kfd0wqdx 61 29 areas area NNS cord-007636-kfd0wqdx 61 30 and and CC cord-007636-kfd0wqdx 61 31 control control NN cord-007636-kfd0wqdx 61 32 brains brain NNS cord-007636-kfd0wqdx 62 1 ( ( -LRB- cord-007636-kfd0wqdx 62 2 Fig Fig NNP cord-007636-kfd0wqdx 62 3 . . NNP cord-007636-kfd0wqdx 62 4 1 1 CD cord-007636-kfd0wqdx 62 5 ) ) -RRB- cord-007636-kfd0wqdx 62 6 . . . cord-007636-kfd0wqdx 63 1 In in IN cord-007636-kfd0wqdx 63 2 unirradiated unirradiated JJ cord-007636-kfd0wqdx 63 3 tumor tumor NN cord-007636-kfd0wqdx 63 4 - - HYPH cord-007636-kfd0wqdx 63 5 bearing bear VBG cord-007636-kfd0wqdx 63 6 animals animal NNS cord-007636-kfd0wqdx 63 7 , , , cord-007636-kfd0wqdx 63 8 no no DT cord-007636-kfd0wqdx 63 9 strong strong JJ cord-007636-kfd0wqdx 63 10 class class NN cord-007636-kfd0wqdx 63 11 I i NN cord-007636-kfd0wqdx 63 12 activity activity NN cord-007636-kfd0wqdx 63 13 was be VBD cord-007636-kfd0wqdx 63 14 seen see VBN cord-007636-kfd0wqdx 63 15 in in IN cord-007636-kfd0wqdx 63 16 the the DT cord-007636-kfd0wqdx 63 17 tumor tumor NN cord-007636-kfd0wqdx 63 18 cells cell NNS cord-007636-kfd0wqdx 63 19 or or CC cord-007636-kfd0wqdx 63 20 the the DT cord-007636-kfd0wqdx 63 21 surrounding surround VBG cord-007636-kfd0wqdx 63 22 neural neural JJ cord-007636-kfd0wqdx 63 23 cells cell NNS cord-007636-kfd0wqdx 63 24 . . . cord-007636-kfd0wqdx 64 1 In in IN cord-007636-kfd0wqdx 64 2 contrast contrast NN cord-007636-kfd0wqdx 64 3 , , , cord-007636-kfd0wqdx 64 4 many many JJ cord-007636-kfd0wqdx 64 5 class class NN cord-007636-kfd0wqdx 64 6 II ii NN cord-007636-kfd0wqdx 64 7 + + CC cord-007636-kfd0wqdx 64 8 cells cell NNS cord-007636-kfd0wqdx 64 9 were be VBD cord-007636-kfd0wqdx 64 10 seen see VBN cord-007636-kfd0wqdx 64 11 , , , cord-007636-kfd0wqdx 64 12 especially especially RB cord-007636-kfd0wqdx 64 13 at at IN cord-007636-kfd0wqdx 64 14 the the DT cord-007636-kfd0wqdx 64 15 periphery periphery NN cord-007636-kfd0wqdx 64 16 of of IN cord-007636-kfd0wqdx 64 17 the the DT cord-007636-kfd0wqdx 64 18 tumors tumor NNS cord-007636-kfd0wqdx 64 19 . . . cord-007636-kfd0wqdx 65 1 The the DT cord-007636-kfd0wqdx 65 2 number number NN cord-007636-kfd0wqdx 65 3 of of IN cord-007636-kfd0wqdx 65 4 class class NN cord-007636-kfd0wqdx 65 5 II II NNP cord-007636-kfd0wqdx 65 6 + + CC cord-007636-kfd0wqdx 65 7 cells cell NNS cord-007636-kfd0wqdx 65 8 increased increase VBD cord-007636-kfd0wqdx 65 9 with with IN cord-007636-kfd0wqdx 65 10 time time NN cord-007636-kfd0wqdx 65 11 after after IN cord-007636-kfd0wqdx 65 12 tumor tumor NN cord-007636-kfd0wqdx 65 13 implantation implantation NN cord-007636-kfd0wqdx 65 14 , , , cord-007636-kfd0wqdx 65 15 reaching reach VBG cord-007636-kfd0wqdx 65 16 40 40 CD cord-007636-kfd0wqdx 65 17 % % NN cord-007636-kfd0wqdx 65 18 of of IN cord-007636-kfd0wqdx 65 19 the the DT cord-007636-kfd0wqdx 65 20 ceils ceil NNS cord-007636-kfd0wqdx 65 21 within within IN cord-007636-kfd0wqdx 65 22 selected select VBN cord-007636-kfd0wqdx 65 23 areas area NNS cord-007636-kfd0wqdx 65 24 of of IN cord-007636-kfd0wqdx 65 25 the the DT cord-007636-kfd0wqdx 65 26 tumor tumor NN cord-007636-kfd0wqdx 65 27 mass mass NN cord-007636-kfd0wqdx 65 28 . . . cord-007636-kfd0wqdx 66 1 Most Most JJS cord-007636-kfd0wqdx 66 2 of of IN cord-007636-kfd0wqdx 66 3 the the DT cord-007636-kfd0wqdx 66 4 class class NN cord-007636-kfd0wqdx 66 5 II II NNP cord-007636-kfd0wqdx 66 6 + + CC cord-007636-kfd0wqdx 66 7 cells cell NNS cord-007636-kfd0wqdx 66 8 had have VBD cord-007636-kfd0wqdx 66 9 a a DT cord-007636-kfd0wqdx 66 10 dendritic dendritic JJ cord-007636-kfd0wqdx 66 11 morphology morphology NN cord-007636-kfd0wqdx 66 12 suggestive suggestive JJ cord-007636-kfd0wqdx 66 13 of of IN cord-007636-kfd0wqdx 66 14 microglia microglia NN cord-007636-kfd0wqdx 66 15 . . . cord-007636-kfd0wqdx 67 1 Rare rare JJ cord-007636-kfd0wqdx 67 2 cells cell NNS cord-007636-kfd0wqdx 67 3 ( ( -LRB- cord-007636-kfd0wqdx 67 4 5 5 CD cord-007636-kfd0wqdx 67 5 % % NN cord-007636-kfd0wqdx 67 6 ) ) -RRB- cord-007636-kfd0wqdx 67 7 had have VBD cord-007636-kfd0wqdx 67 8 the the DT cord-007636-kfd0wqdx 67 9 morphologic morphologic JJ cord-007636-kfd0wqdx 67 10 characteristics characteristic NNS cord-007636-kfd0wqdx 67 11 of of IN cord-007636-kfd0wqdx 67 12 macrophages macrophage NNS cord-007636-kfd0wqdx 67 13 , , , cord-007636-kfd0wqdx 67 14 lymphocytes lymphocyte NNS cord-007636-kfd0wqdx 67 15 , , , cord-007636-kfd0wqdx 67 16 and and CC cord-007636-kfd0wqdx 67 17 occasionally occasionally RB cord-007636-kfd0wqdx 67 18 astrocytes astrocyte VBZ cord-007636-kfd0wqdx 67 19 . . . cord-007636-kfd0wqdx 68 1 Neither neither CC cord-007636-kfd0wqdx 68 2 the the DT cord-007636-kfd0wqdx 68 3 numbers number NNS cord-007636-kfd0wqdx 68 4 nor nor CC cord-007636-kfd0wqdx 68 5 the the DT cord-007636-kfd0wqdx 68 6 proportions proportion NNS cord-007636-kfd0wqdx 68 7 of of IN cord-007636-kfd0wqdx 68 8 cells cell NNS cord-007636-kfd0wqdx 68 9 were be VBD cord-007636-kfd0wqdx 68 10 significantly significantly RB cord-007636-kfd0wqdx 68 11 changed change VBN cord-007636-kfd0wqdx 68 12 following follow VBG cord-007636-kfd0wqdx 68 13 irradiation irradiation NN cord-007636-kfd0wqdx 68 14 . . . cord-007636-kfd0wqdx 69 1 These these DT cord-007636-kfd0wqdx 69 2 identifications identification NNS cord-007636-kfd0wqdx 69 3 were be VBD cord-007636-kfd0wqdx 69 4 confirmed confirm VBN cord-007636-kfd0wqdx 69 5 by by IN cord-007636-kfd0wqdx 69 6 serial serial JJ cord-007636-kfd0wqdx 69 7 sections section NNS cord-007636-kfd0wqdx 69 8 stained stain VBN cord-007636-kfd0wqdx 69 9 with with IN cord-007636-kfd0wqdx 69 10 OX6 ox6 NN cord-007636-kfd0wqdx 69 11 and and CC cord-007636-kfd0wqdx 69 12 antibody antibody NN cord-007636-kfd0wqdx 69 13 to to IN cord-007636-kfd0wqdx 69 14 GFAP GFAP NNP cord-007636-kfd0wqdx 69 15 and and CC cord-007636-kfd0wqdx 69 16 with with IN cord-007636-kfd0wqdx 69 17 OX6 OX6 NNP cord-007636-kfd0wqdx 69 18 and and CC cord-007636-kfd0wqdx 69 19 OX42 OX42 NNP cord-007636-kfd0wqdx 69 20 . . . cord-007636-kfd0wqdx 70 1 Two two CD cord-007636-kfd0wqdx 70 2 kinds kind NNS cord-007636-kfd0wqdx 70 3 of of IN cord-007636-kfd0wqdx 70 4 evidence evidence NN cord-007636-kfd0wqdx 70 5 suggest suggest VBP cord-007636-kfd0wqdx 70 6 that that IN cord-007636-kfd0wqdx 70 7 the the DT cord-007636-kfd0wqdx 70 8 class class NN cord-007636-kfd0wqdx 70 9 II ii NN cord-007636-kfd0wqdx 70 10 - - HYPH cord-007636-kfd0wqdx 70 11 positive positive JJ cord-007636-kfd0wqdx 70 12 cells cell NNS cord-007636-kfd0wqdx 70 13 were be VBD cord-007636-kfd0wqdx 70 14 not not RB cord-007636-kfd0wqdx 70 15 tumor tumor NN cord-007636-kfd0wqdx 70 16 cells cell NNS cord-007636-kfd0wqdx 70 17 . . . cord-007636-kfd0wqdx 71 1 In in IN cord-007636-kfd0wqdx 71 2 vitro vitro FW cord-007636-kfd0wqdx 71 3 , , , cord-007636-kfd0wqdx 71 4 no no DT cord-007636-kfd0wqdx 71 5 class class NN cord-007636-kfd0wqdx 71 6 II II NNP cord-007636-kfd0wqdx 71 7 was be VBD cord-007636-kfd0wqdx 71 8 detected detect VBN cord-007636-kfd0wqdx 71 9 on on IN cord-007636-kfd0wqdx 71 10 9L 9l CD cord-007636-kfd0wqdx 71 11 cells cell NNS cord-007636-kfd0wqdx 71 12 , , , cord-007636-kfd0wqdx 71 13 even even RB cord-007636-kfd0wqdx 71 14 after after IN cord-007636-kfd0wqdx 71 15 incubation incubation NN cord-007636-kfd0wqdx 71 16 with with IN cord-007636-kfd0wqdx 71 17 IFN IFN NNP cord-007636-kfd0wqdx 71 18 - - HYPH cord-007636-kfd0wqdx 71 19 T T NNP cord-007636-kfd0wqdx 71 20 , , , cord-007636-kfd0wqdx 71 21 suggesting suggest VBG cord-007636-kfd0wqdx 71 22 that that IN cord-007636-kfd0wqdx 71 23 the the DT cord-007636-kfd0wqdx 71 24 9L 9l CD cord-007636-kfd0wqdx 71 25 cells cell NNS cord-007636-kfd0wqdx 71 26 may may MD cord-007636-kfd0wqdx 71 27 not not RB cord-007636-kfd0wqdx 71 28 have have VB cord-007636-kfd0wqdx 71 29 the the DT cord-007636-kfd0wqdx 71 30 potential potential NN cord-007636-kfd0wqdx 71 31 to to TO cord-007636-kfd0wqdx 71 32 express express VB cord-007636-kfd0wqdx 71 33 class class NN cord-007636-kfd0wqdx 71 34 II II NNP cord-007636-kfd0wqdx 71 35 MHC MHC NNP cord-007636-kfd0wqdx 71 36 molecules molecule NNS cord-007636-kfd0wqdx 71 37 . . . cord-007636-kfd0wqdx 72 1 In in IN cord-007636-kfd0wqdx 72 2 work work NN cord-007636-kfd0wqdx 72 3 to to TO cord-007636-kfd0wqdx 72 4 be be VB cord-007636-kfd0wqdx 72 5 reported report VBN cord-007636-kfd0wqdx 72 6 separately separately RB cord-007636-kfd0wqdx 72 7 , , , cord-007636-kfd0wqdx 72 8 9L 9l CD cord-007636-kfd0wqdx 72 9 cells cell NNS cord-007636-kfd0wqdx 72 10 were be VBD cord-007636-kfd0wqdx 72 11 transfected transfecte VBN cord-007636-kfd0wqdx 72 12 with with IN cord-007636-kfd0wqdx 72 13 the the DT cord-007636-kfd0wqdx 72 14 Escherichia Escherichia NNP cord-007636-kfd0wqdx 72 15 coli coli NNS cord-007636-kfd0wqdx 72 16 fl fl NNP cord-007636-kfd0wqdx 72 17 - - HYPH cord-007636-kfd0wqdx 72 18 galactosidase galactosidase NN cord-007636-kfd0wqdx 72 19 gene gene NN cord-007636-kfd0wqdx 72 20 so so IN cord-007636-kfd0wqdx 72 21 that that IN cord-007636-kfd0wqdx 72 22 they -PRON- PRP cord-007636-kfd0wqdx 72 23 could could MD cord-007636-kfd0wqdx 72 24 be be VB cord-007636-kfd0wqdx 72 25 identified identify VBN cord-007636-kfd0wqdx 72 26 histochemically histochemically RB cord-007636-kfd0wqdx 72 27 ( ( -LRB- cord-007636-kfd0wqdx 72 28 Lampson Lampson NNP cord-007636-kfd0wqdx 72 29 et et NNP cord-007636-kfd0wqdx 72 30 al al NNP cord-007636-kfd0wqdx 72 31 . . NNP cord-007636-kfd0wqdx 72 32 , , , cord-007636-kfd0wqdx 72 33 1989 1989 CD cord-007636-kfd0wqdx 72 34 ) ) -RRB- cord-007636-kfd0wqdx 72 35 . . . cord-007636-kfd0wqdx 73 1 Double double JJ cord-007636-kfd0wqdx 73 2 - - HYPH cord-007636-kfd0wqdx 73 3 labelling labelling NN cord-007636-kfd0wqdx 73 4 studies study NNS cord-007636-kfd0wqdx 73 5 using use VBG cord-007636-kfd0wqdx 73 6 the the DT cord-007636-kfd0wqdx 73 7 modified modify VBN cord-007636-kfd0wqdx 73 8 cells cell NNS cord-007636-kfd0wqdx 73 9 did do VBD cord-007636-kfd0wqdx 73 10 not not RB cord-007636-kfd0wqdx 73 11 reveal reveal VB cord-007636-kfd0wqdx 73 12 class class NN cord-007636-kfd0wqdx 73 13 II ii NN cord-007636-kfd0wqdx 73 14 - - HYPH cord-007636-kfd0wqdx 73 15 positive positive JJ cord-007636-kfd0wqdx 73 16 tumor tumor NN cord-007636-kfd0wqdx 73 17 cells cell NNS cord-007636-kfd0wqdx 73 18 within within IN cord-007636-kfd0wqdx 73 19 the the DT cord-007636-kfd0wqdx 73 20 brain brain NN cord-007636-kfd0wqdx 73 21 . . . cord-007636-kfd0wqdx 74 1 Many many JJ cord-007636-kfd0wqdx 74 2 infiltrating infiltrate VBG cord-007636-kfd0wqdx 74 3 leucocytes leucocyte NNS cord-007636-kfd0wqdx 74 4 were be VBD cord-007636-kfd0wqdx 74 5 also also RB cord-007636-kfd0wqdx 74 6 seen see VBN cord-007636-kfd0wqdx 74 7 in in IN cord-007636-kfd0wqdx 74 8 the the DT cord-007636-kfd0wqdx 74 9 tumor tumor NN cord-007636-kfd0wqdx 74 10 - - HYPH cord-007636-kfd0wqdx 74 11 containing contain VBG cord-007636-kfd0wqdx 74 12 areas area NNS cord-007636-kfd0wqdx 74 13 . . . cord-007636-kfd0wqdx 75 1 As as RB cord-007636-kfd0wqdx 75 2 many many JJ cord-007636-kfd0wqdx 75 3 as as IN cord-007636-kfd0wqdx 75 4 40 40 CD cord-007636-kfd0wqdx 75 5 % % NN cord-007636-kfd0wqdx 75 6 of of IN cord-007636-kfd0wqdx 75 7 the the DT cord-007636-kfd0wqdx 75 8 cells cell NNS cord-007636-kfd0wqdx 75 9 within within IN cord-007636-kfd0wqdx 75 10 the the DT cord-007636-kfd0wqdx 75 11 tumors tumor NNS cord-007636-kfd0wqdx 75 12 were be VBD cord-007636-kfd0wqdx 76 1 LCA LCA NNP cord-007636-kfd0wqdx 76 2 ÷. ÷. NNP cord-007636-kfd0wqdx 76 3 Analysis Analysis NNP cord-007636-kfd0wqdx 76 4 of of IN cord-007636-kfd0wqdx 76 5 lymphocyte lymphocyte NN cord-007636-kfd0wqdx 76 6 subsets subset NNS cord-007636-kfd0wqdx 76 7 showed show VBD cord-007636-kfd0wqdx 76 8 many many JJ cord-007636-kfd0wqdx 76 9 T t NN cord-007636-kfd0wqdx 76 10 cells cell NNS cord-007636-kfd0wqdx 76 11 , , , cord-007636-kfd0wqdx 76 12 including include VBG cord-007636-kfd0wqdx 76 13 helper helper NN cord-007636-kfd0wqdx 76 14 cells cell NNS cord-007636-kfd0wqdx 76 15 ( ( -LRB- cord-007636-kfd0wqdx 76 16 up up IN cord-007636-kfd0wqdx 76 17 to to TO cord-007636-kfd0wqdx 76 18 25 25 CD cord-007636-kfd0wqdx 76 19 % % NN cord-007636-kfd0wqdx 76 20 of of IN cord-007636-kfd0wqdx 76 21 all all DT cord-007636-kfd0wqdx 76 22 cells cell NNS cord-007636-kfd0wqdx 76 23 within within IN cord-007636-kfd0wqdx 76 24 the the DT cord-007636-kfd0wqdx 76 25 tumor tumor NN cord-007636-kfd0wqdx 76 26 mass mass NN cord-007636-kfd0wqdx 76 27 ) ) -RRB- cord-007636-kfd0wqdx 76 28 , , , cord-007636-kfd0wqdx 76 29 fewer few JJR cord-007636-kfd0wqdx 76 30 cytotoxic cytotoxic JJ cord-007636-kfd0wqdx 76 31 / / SYM cord-007636-kfd0wqdx 76 32 suppressor suppressor NN cord-007636-kfd0wqdx 76 33 cells cell NNS cord-007636-kfd0wqdx 76 34 ( ( -LRB- cord-007636-kfd0wqdx 76 35 up up IN cord-007636-kfd0wqdx 76 36 to to TO cord-007636-kfd0wqdx 76 37 12 12 CD cord-007636-kfd0wqdx 76 38 % % NN cord-007636-kfd0wqdx 76 39 ) ) -RRB- cord-007636-kfd0wqdx 76 40 and and CC cord-007636-kfd0wqdx 76 41 rare rare JJ cord-007636-kfd0wqdx 76 42 B b NN cord-007636-kfd0wqdx 76 43 cells cell NNS cord-007636-kfd0wqdx 76 44 ( ( -LRB- cord-007636-kfd0wqdx 76 45 less less JJR cord-007636-kfd0wqdx 76 46 than than IN cord-007636-kfd0wqdx 76 47 5 5 CD cord-007636-kfd0wqdx 76 48 % % NN cord-007636-kfd0wqdx 76 49 ) ) -RRB- cord-007636-kfd0wqdx 76 50 . . . cord-007636-kfd0wqdx 77 1 In in IN cord-007636-kfd0wqdx 77 2 control control NN cord-007636-kfd0wqdx 77 3 studies study NNS cord-007636-kfd0wqdx 77 4 , , , cord-007636-kfd0wqdx 77 5 9L 9l CD cord-007636-kfd0wqdx 77 6 cells cell NNS cord-007636-kfd0wqdx 77 7 themselves -PRON- PRP cord-007636-kfd0wqdx 77 8 did do VBD cord-007636-kfd0wqdx 77 9 not not RB cord-007636-kfd0wqdx 77 10 crossreact crossreact VB cord-007636-kfd0wqdx 77 11 with with IN cord-007636-kfd0wqdx 77 12 the the DT cord-007636-kfd0wqdx 77 13 antibodies antibody NNS cord-007636-kfd0wqdx 77 14 to to TO cord-007636-kfd0wqdx 77 15 lymphocyte lymphocyte NN cord-007636-kfd0wqdx 77 16 subsets subset NNS cord-007636-kfd0wqdx 77 17 . . . cord-007636-kfd0wqdx 78 1 Irradiation irradiation NN cord-007636-kfd0wqdx 78 2 produced produce VBD cord-007636-kfd0wqdx 78 3 only only RB cord-007636-kfd0wqdx 78 4 slight slight JJ cord-007636-kfd0wqdx 78 5 necrosis necrosis NN cord-007636-kfd0wqdx 78 6 . . . cord-007636-kfd0wqdx 79 1 There there EX cord-007636-kfd0wqdx 79 2 was be VBD cord-007636-kfd0wqdx 79 3 no no DT cord-007636-kfd0wqdx 79 4 significant significant JJ cord-007636-kfd0wqdx 79 5 effect effect NN cord-007636-kfd0wqdx 79 6 on on IN cord-007636-kfd0wqdx 79 7 class class NN cord-007636-kfd0wqdx 79 8 I -PRON- PRP cord-007636-kfd0wqdx 79 9 MHC MHC NNP cord-007636-kfd0wqdx 79 10 expression expression NN cord-007636-kfd0wqdx 79 11 in in IN cord-007636-kfd0wqdx 79 12 tumor tumor NN cord-007636-kfd0wqdx 79 13 - - HYPH cord-007636-kfd0wqdx 79 14 bearing bear VBG cord-007636-kfd0wqdx 79 15 rats rat NNS cord-007636-kfd0wqdx 79 16 . . . cord-007636-kfd0wqdx 80 1 No no DT cord-007636-kfd0wqdx 80 2 significant significant JJ cord-007636-kfd0wqdx 80 3 change change NN cord-007636-kfd0wqdx 80 4 243 243 CD cord-007636-kfd0wqdx 80 5 was be VBD cord-007636-kfd0wqdx 80 6 noted note VBN cord-007636-kfd0wqdx 80 7 in in IN cord-007636-kfd0wqdx 80 8 class class NN cord-007636-kfd0wqdx 80 9 II II NNP cord-007636-kfd0wqdx 80 10 MHC MHC NNP cord-007636-kfd0wqdx 80 11 expression expression NN cord-007636-kfd0wqdx 80 12 or or CC cord-007636-kfd0wqdx 80 13 lymphocytic lymphocytic JJ cord-007636-kfd0wqdx 80 14 infiltration infiltration NN cord-007636-kfd0wqdx 80 15 on on IN cord-007636-kfd0wqdx 80 16 the the DT cord-007636-kfd0wqdx 80 17 first first JJ cord-007636-kfd0wqdx 80 18 2 2 CD cord-007636-kfd0wqdx 80 19 days day NNS cord-007636-kfd0wqdx 80 20 after after IN cord-007636-kfd0wqdx 80 21 irradiation irradiation NN cord-007636-kfd0wqdx 80 22 . . . cord-007636-kfd0wqdx 81 1 From from IN cord-007636-kfd0wqdx 81 2 day day NN cord-007636-kfd0wqdx 81 3 3 3 CD cord-007636-kfd0wqdx 81 4 onwards onwards RB cord-007636-kfd0wqdx 81 5 there there EX cord-007636-kfd0wqdx 81 6 was be VBD cord-007636-kfd0wqdx 81 7 a a DT cord-007636-kfd0wqdx 81 8 slight slight JJ cord-007636-kfd0wqdx 81 9 increase increase NN cord-007636-kfd0wqdx 81 10 in in IN cord-007636-kfd0wqdx 81 11 the the DT cord-007636-kfd0wqdx 81 12 numbers number NNS cord-007636-kfd0wqdx 81 13 of of IN cord-007636-kfd0wqdx 81 14 class class NN cord-007636-kfd0wqdx 81 15 II ii NN cord-007636-kfd0wqdx 81 16 - - HYPH cord-007636-kfd0wqdx 81 17 positive positive JJ cord-007636-kfd0wqdx 81 18 cells cell NNS cord-007636-kfd0wqdx 81 19 and and CC cord-007636-kfd0wqdx 81 20 lymphocytes lymphocyte NNS cord-007636-kfd0wqdx 81 21 in in IN cord-007636-kfd0wqdx 81 22 the the DT cord-007636-kfd0wqdx 81 23 irradiated irradiate VBN cord-007636-kfd0wqdx 81 24 tumors tumor NNS cord-007636-kfd0wqdx 81 25 . . . cord-007636-kfd0wqdx 82 1 However however RB cord-007636-kfd0wqdx 82 2 , , , cord-007636-kfd0wqdx 82 3 these these DT cord-007636-kfd0wqdx 82 4 differences difference NNS cord-007636-kfd0wqdx 82 5 did do VBD cord-007636-kfd0wqdx 82 6 not not RB cord-007636-kfd0wqdx 82 7 reach reach VB cord-007636-kfd0wqdx 82 8 statistical statistical JJ cord-007636-kfd0wqdx 82 9 significance significance NN cord-007636-kfd0wqdx 82 10 in in IN cord-007636-kfd0wqdx 82 11 the the DT cord-007636-kfd0wqdx 82 12 Wilcoxon Wilcoxon NNP cord-007636-kfd0wqdx 82 13 sign sign NN cord-007636-kfd0wqdx 82 14 rank rank NN cord-007636-kfd0wqdx 82 15 test test NN cord-007636-kfd0wqdx 82 16 ( ( -LRB- cord-007636-kfd0wqdx 82 17 Figs fig NNS cord-007636-kfd0wqdx 82 18 . . . cord-007636-kfd0wqdx 83 1 2 2 CD cord-007636-kfd0wqdx 83 2 _SP cord-007636-kfd0wqdx 83 3 and and CC cord-007636-kfd0wqdx 83 4 3 3 CD cord-007636-kfd0wqdx 83 5 ) ) -RRB- cord-007636-kfd0wqdx 84 1 . . . cord-007636-kfd0wqdx 85 1 Under under IN cord-007636-kfd0wqdx 85 2 normal normal JJ cord-007636-kfd0wqdx 85 3 circumstances circumstance NNS cord-007636-kfd0wqdx 85 4 there there EX cord-007636-kfd0wqdx 85 5 is be VBZ cord-007636-kfd0wqdx 85 6 little little JJ cord-007636-kfd0wqdx 85 7 detectable detectable JJ cord-007636-kfd0wqdx 85 8 MHC MHC NNP cord-007636-kfd0wqdx 85 9 expression expression NN cord-007636-kfd0wqdx 85 10 on on IN cord-007636-kfd0wqdx 85 11 neural neural JJ cord-007636-kfd0wqdx 85 12 cells cell NNS cord-007636-kfd0wqdx 85 13 or or CC cord-007636-kfd0wqdx 85 14 lymphocytic lymphocytic JJ cord-007636-kfd0wqdx 85 15 infiltration infiltration NN cord-007636-kfd0wqdx 85 16 in in IN cord-007636-kfd0wqdx 85 17 the the DT cord-007636-kfd0wqdx 85 18 brain brain NN cord-007636-kfd0wqdx 85 19 . . . cord-007636-kfd0wqdx 86 1 However however RB cord-007636-kfd0wqdx 86 2 , , , cord-007636-kfd0wqdx 86 3 both both DT cord-007636-kfd0wqdx 86 4 enhanced enhance VBD cord-007636-kfd0wqdx 86 5 MHC MHC NNP cord-007636-kfd0wqdx 86 6 expression expression NN cord-007636-kfd0wqdx 86 7 and and CC cord-007636-kfd0wqdx 86 8 lymphocytic lymphocytic JJ cord-007636-kfd0wqdx 86 9 infiltration infiltration NN cord-007636-kfd0wqdx 86 10 can can MD cord-007636-kfd0wqdx 86 11 occur occur VB cord-007636-kfd0wqdx 86 12 in in IN cord-007636-kfd0wqdx 86 13 a a DT cord-007636-kfd0wqdx 86 14 variety variety NN cord-007636-kfd0wqdx 86 15 of of IN cord-007636-kfd0wqdx 86 16 conditions condition NNS cord-007636-kfd0wqdx 86 17 , , , cord-007636-kfd0wqdx 86 18 enabling enable VBG cord-007636-kfd0wqdx 86 19 neural neural JJ cord-007636-kfd0wqdx 86 20 cells cell NNS cord-007636-kfd0wqdx 86 21 to to TO cord-007636-kfd0wqdx 86 22 become become VB cord-007636-kfd0wqdx 86 23 subjected subject VBN cord-007636-kfd0wqdx 86 24 to to IN cord-007636-kfd0wqdx 86 25 cellmediated cellmediate VBN cord-007636-kfd0wqdx 86 26 immune immune JJ cord-007636-kfd0wqdx 86 27 reactions reaction NNS cord-007636-kfd0wqdx 86 28 ( ( -LRB- cord-007636-kfd0wqdx 86 29 Sobel Sobel NNP cord-007636-kfd0wqdx 86 30 et et NNP cord-007636-kfd0wqdx 86 31 al al NNP cord-007636-kfd0wqdx 86 32 . . NNP cord-007636-kfd0wqdx 86 33 , , , cord-007636-kfd0wqdx 86 34 1984 1984 CD cord-007636-kfd0wqdx 86 35 ; ; : cord-007636-kfd0wqdx 86 36 Wong Wong NNP cord-007636-kfd0wqdx 86 37 et et NNP cord-007636-kfd0wqdx 86 38 al al NNP cord-007636-kfd0wqdx 86 39 . . NNP cord-007636-kfd0wqdx 86 40 , , , cord-007636-kfd0wqdx 86 41 1985 1985 CD cord-007636-kfd0wqdx 86 42 ; ; : cord-007636-kfd0wqdx 86 43 Lampson Lampson NNP cord-007636-kfd0wqdx 86 44 and and CC cord-007636-kfd0wqdx 86 45 Hickey Hickey NNP cord-007636-kfd0wqdx 86 46 , , , cord-007636-kfd0wqdx 86 47 1986 1986 CD cord-007636-kfd0wqdx 86 48 ; ; : cord-007636-kfd0wqdx 86 49 Suzumura Suzumura NNP cord-007636-kfd0wqdx 86 50 et et NNP cord-007636-kfd0wqdx 86 51 al al NNP cord-007636-kfd0wqdx 86 52 . . . cord-007636-kfd0wqdx 87 1 , , , cord-007636-kfd0wqdx 87 2 1986 1986 CD cord-007636-kfd0wqdx 87 3 ; ; : cord-007636-kfd0wqdx 87 4 Lampson Lampson NNP cord-007636-kfd0wqdx 87 5 , , , cord-007636-kfd0wqdx 87 6 1987 1987 CD cord-007636-kfd0wqdx 87 7 ; ; : cord-007636-kfd0wqdx 87 8 Traugott Traugott NNP cord-007636-kfd0wqdx 87 9 , , , cord-007636-kfd0wqdx 87 10 1987 1987 CD cord-007636-kfd0wqdx 87 11 ; ; : cord-007636-kfd0wqdx 87 12 McGeer mcgeer UH cord-007636-kfd0wqdx 87 13 et et NNP cord-007636-kfd0wqdx 87 14 al al NNP cord-007636-kfd0wqdx 87 15 . . NNP cord-007636-kfd0wqdx 87 16 , , , cord-007636-kfd0wqdx 87 17 1988 1988 CD cord-007636-kfd0wqdx 87 18 ; ; : cord-007636-kfd0wqdx 87 19 Streit Streit NNP cord-007636-kfd0wqdx 87 20 et et NNP cord-007636-kfd0wqdx 87 21 al al NNP cord-007636-kfd0wqdx 87 22 . . NNP cord-007636-kfd0wqdx 87 23 , , , cord-007636-kfd0wqdx 87 24 1989 1989 CD cord-007636-kfd0wqdx 87 25 ) ) -RRB- cord-007636-kfd0wqdx 87 26 . . . cord-007636-kfd0wqdx 88 1 In in IN cord-007636-kfd0wqdx 88 2 this this DT cord-007636-kfd0wqdx 88 3 study study NN cord-007636-kfd0wqdx 88 4 , , , cord-007636-kfd0wqdx 88 5 we -PRON- PRP cord-007636-kfd0wqdx 88 6 have have VBP cord-007636-kfd0wqdx 88 7 found find VBN cord-007636-kfd0wqdx 88 8 that that IN cord-007636-kfd0wqdx 88 9 a a DT cord-007636-kfd0wqdx 88 10 dose dose NN cord-007636-kfd0wqdx 88 11 of of IN cord-007636-kfd0wqdx 88 12 irradiation irradiation NN cord-007636-kfd0wqdx 88 13 biologically biologically RB cord-007636-kfd0wqdx 88 14 equivalent equivalent JJ cord-007636-kfd0wqdx 88 15 to to IN cord-007636-kfd0wqdx 88 16 that that DT cord-007636-kfd0wqdx 88 17 used use VBN cord-007636-kfd0wqdx 88 18 in in IN cord-007636-kfd0wqdx 88 19 the the DT cord-007636-kfd0wqdx 88 20 treatment treatment NN cord-007636-kfd0wqdx 88 21 of of IN cord-007636-kfd0wqdx 88 22 malignant malignant JJ cord-007636-kfd0wqdx 88 23 glioma glioma NN cord-007636-kfd0wqdx 88 24 did do VBD cord-007636-kfd0wqdx 88 25 not not RB cord-007636-kfd0wqdx 88 26 produce produce VB cord-007636-kfd0wqdx 88 27 major major JJ cord-007636-kfd0wqdx 88 28 histologic histologic JJ cord-007636-kfd0wqdx 88 29 changes change NNS cord-007636-kfd0wqdx 88 30 , , , cord-007636-kfd0wqdx 88 31 leucocytic leucocytic JJ cord-007636-kfd0wqdx 88 32 infiltration infiltration NN cord-007636-kfd0wqdx 88 33 , , , cord-007636-kfd0wqdx 88 34 or or CC cord-007636-kfd0wqdx 88 35 induction induction NN cord-007636-kfd0wqdx 88 36 of of IN cord-007636-kfd0wqdx 88 37 MHC MHC NNP cord-007636-kfd0wqdx 88 38 antigens antigen NNS cord-007636-kfd0wqdx 88 39 in in IN cord-007636-kfd0wqdx 88 40 the the DT cord-007636-kfd0wqdx 88 41 brain brain NN cord-007636-kfd0wqdx 88 42 in in IN cord-007636-kfd0wqdx 88 43 the the DT cord-007636-kfd0wqdx 88 44 time time NN cord-007636-kfd0wqdx 88 45 covered cover VBN cord-007636-kfd0wqdx 88 46 . . . cord-007636-kfd0wqdx 89 1 Surprisingly surprisingly RB cord-007636-kfd0wqdx 89 2 , , , cord-007636-kfd0wqdx 89 3 our -PRON- PRP$ cord-007636-kfd0wqdx 89 4 study study NN cord-007636-kfd0wqdx 89 5 also also RB cord-007636-kfd0wqdx 89 6 suggested suggest VBD cord-007636-kfd0wqdx 89 7 that that IN cord-007636-kfd0wqdx 89 8 irradiation irradiation NN cord-007636-kfd0wqdx 89 9 did do VBD cord-007636-kfd0wqdx 89 10 not not RB cord-007636-kfd0wqdx 89 11 decrease decrease VB cord-007636-kfd0wqdx 89 12 class class NN cord-007636-kfd0wqdx 89 13 II II NNP cord-007636-kfd0wqdx 89 14 MHC MHC NNP cord-007636-kfd0wqdx 89 15 expression expression NN cord-007636-kfd0wqdx 89 16 or or CC cord-007636-kfd0wqdx 89 17 lymphocytic lymphocytic JJ cord-007636-kfd0wqdx 89 18 infiltration infiltration NN cord-007636-kfd0wqdx 89 19 in in IN cord-007636-kfd0wqdx 89 20 the the DT cord-007636-kfd0wqdx 89 21 9L 9l CD cord-007636-kfd0wqdx 89 22 gliosarcoma gliosarcoma NNP cord-007636-kfd0wqdx 89 23 brain brain NNP cord-007636-kfd0wqdx 89 24 tumor tumor NN cord-007636-kfd0wqdx 89 25 model model NN cord-007636-kfd0wqdx 89 26 . . . cord-007636-kfd0wqdx 90 1 These these DT cord-007636-kfd0wqdx 90 2 findings finding NNS cord-007636-kfd0wqdx 90 3 lay lie VBD cord-007636-kfd0wqdx 90 4 a a DT cord-007636-kfd0wqdx 90 5 foundation foundation NN cord-007636-kfd0wqdx 90 6 for for IN cord-007636-kfd0wqdx 90 7 future future JJ cord-007636-kfd0wqdx 90 8 studies study NNS cord-007636-kfd0wqdx 90 9 of of IN cord-007636-kfd0wqdx 90 10 immunomodulation immunomodulation NN cord-007636-kfd0wqdx 90 11 in in IN cord-007636-kfd0wqdx 90 12 the the DT cord-007636-kfd0wqdx 90 13 brain brain NN cord-007636-kfd0wqdx 90 14 when when WRB cord-007636-kfd0wqdx 90 15 , , , cord-007636-kfd0wqdx 90 16 as as IN cord-007636-kfd0wqdx 90 17 in in IN cord-007636-kfd0wqdx 90 18 the the DT cord-007636-kfd0wqdx 90 19 case case NN cord-007636-kfd0wqdx 90 20 of of IN cord-007636-kfd0wqdx 90 21 brain brain NN cord-007636-kfd0wqdx 90 22 tumor tumor NN cord-007636-kfd0wqdx 90 23 patients patient NNS cord-007636-kfd0wqdx 90 24 , , , cord-007636-kfd0wqdx 90 25 high high JJ cord-007636-kfd0wqdx 90 26 doses dose NNS cord-007636-kfd0wqdx 90 27 of of IN cord-007636-kfd0wqdx 90 28 radiotherapy radiotherapy NN cord-007636-kfd0wqdx 90 29 have have VBP cord-007636-kfd0wqdx 90 30 been be VBN cord-007636-kfd0wqdx 90 31 given give VBN cord-007636-kfd0wqdx 90 32 previously previously RB cord-007636-kfd0wqdx 90 33 . . . cord-007636-kfd0wqdx 91 1 Nominal nominal JJ cord-007636-kfd0wqdx 91 2 standard standard JJ cord-007636-kfd0wqdx 91 3 dose dose NN cord-007636-kfd0wqdx 91 4 and and CC cord-007636-kfd0wqdx 91 5 the the DT cord-007636-kfd0wqdx 91 6 rat rat NN cord-007636-kfd0wqdx 91 7 Systemic Systemic NNP cord-007636-kfd0wqdx 91 8 administration administration NN cord-007636-kfd0wqdx 91 9 of of IN cord-007636-kfd0wqdx 91 10 recombinant recombinant JJ cord-007636-kfd0wqdx 91 11 interleukin interleukin NN cord-007636-kfd0wqdx 91 12 2 2 CD cord-007636-kfd0wqdx 91 13 stimulates stimulate VBZ cord-007636-kfd0wqdx 91 14 in in IN cord-007636-kfd0wqdx 91 15 vivo vivo NN cord-007636-kfd0wqdx 91 16 lymphoid lymphoid JJ cord-007636-kfd0wqdx 91 17 proliferation proliferation NN cord-007636-kfd0wqdx 91 18 in in IN cord-007636-kfd0wqdx 91 19 tissues tissue NNS cord-007636-kfd0wqdx 91 20 Regression regression NN cord-007636-kfd0wqdx 91 21 and and CC cord-007636-kfd0wqdx 91 22 inhibition inhibition NN cord-007636-kfd0wqdx 91 23 of of IN cord-007636-kfd0wqdx 91 24 sarcoma sarcoma NN cord-007636-kfd0wqdx 91 25 growth growth NN cord-007636-kfd0wqdx 91 26 by by IN cord-007636-kfd0wqdx 91 27 interference interference NN cord-007636-kfd0wqdx 91 28 with with IN cord-007636-kfd0wqdx 91 29 a a DT cord-007636-kfd0wqdx 91 30 radiosensitive radiosensitive JJ cord-007636-kfd0wqdx 91 31 T t NN cord-007636-kfd0wqdx 91 32 - - HYPH cord-007636-kfd0wqdx 91 33 cell cell NN cord-007636-kfd0wqdx 91 34 population population NN cord-007636-kfd0wqdx 91 35 Radiation radiation NN cord-007636-kfd0wqdx 91 36 therapy therapy NN cord-007636-kfd0wqdx 91 37 of of IN cord-007636-kfd0wqdx 91 38 9L 9l CD cord-007636-kfd0wqdx 91 39 rat rat NNP cord-007636-kfd0wqdx 91 40 brain brain NN cord-007636-kfd0wqdx 91 41 tumors tumor NNS cord-007636-kfd0wqdx 92 1 Decreased decrease VBN cord-007636-kfd0wqdx 92 2 expression expression NN cord-007636-kfd0wqdx 92 3 of of IN cord-007636-kfd0wqdx 92 4 HLA HLA NNP cord-007636-kfd0wqdx 92 5 class class NN cord-007636-kfd0wqdx 92 6 II II NNP cord-007636-kfd0wqdx 92 7 antigens antigen NNS cord-007636-kfd0wqdx 92 8 on on IN cord-007636-kfd0wqdx 92 9 human human JJ cord-007636-kfd0wqdx 92 10 uveal uveal JJ cord-007636-kfd0wqdx 92 11 melanoma melanoma NN cord-007636-kfd0wqdx 92 12 cells cell NNS cord-007636-kfd0wqdx 92 13 after after IN cord-007636-kfd0wqdx 92 14 in in IN cord-007636-kfd0wqdx 93 1 vivo vivo NNP cord-007636-kfd0wqdx 93 2 X x NN cord-007636-kfd0wqdx 93 3 - - NN cord-007636-kfd0wqdx 93 4 ray ray NN cord-007636-kfd0wqdx 93 5 irradiation irradiation NN cord-007636-kfd0wqdx 93 6 An an DT cord-007636-kfd0wqdx 93 7 improved improved JJ cord-007636-kfd0wqdx 93 8 rat rat NN cord-007636-kfd0wqdx 93 9 brain brain NN cord-007636-kfd0wqdx 93 10 tumor tumor NN cord-007636-kfd0wqdx 93 11 model model NN cord-007636-kfd0wqdx 93 12 Therapeutic therapeutic JJ cord-007636-kfd0wqdx 93 13 trials trial NNS cord-007636-kfd0wqdx 93 14 in in IN cord-007636-kfd0wqdx 93 15 the the DT cord-007636-kfd0wqdx 93 16 management management NN cord-007636-kfd0wqdx 93 17 of of IN cord-007636-kfd0wqdx 93 18 metastatic metastatic JJ cord-007636-kfd0wqdx 93 19 brain brain NN cord-007636-kfd0wqdx 93 20 tumors tumor NNS cord-007636-kfd0wqdx 93 21 by by IN cord-007636-kfd0wqdx 93 22 different different JJ cord-007636-kfd0wqdx 93 23 time time NN cord-007636-kfd0wqdx 93 24 / / SYM cord-007636-kfd0wqdx 93 25 dose dose NN cord-007636-kfd0wqdx 93 26 fraction fraction NN cord-007636-kfd0wqdx 93 27 schemes scheme NNS cord-007636-kfd0wqdx 93 28 of of IN cord-007636-kfd0wqdx 93 29 radiation radiation NN cord-007636-kfd0wqdx 93 30 therapy therapy NN cord-007636-kfd0wqdx 93 31 Molecular molecular JJ cord-007636-kfd0wqdx 93 32 basis basis NN cord-007636-kfd0wqdx 93 33 of of IN cord-007636-kfd0wqdx 93 34 the the DT cord-007636-kfd0wqdx 93 35 immune immune JJ cord-007636-kfd0wqdx 93 36 response response NN cord-007636-kfd0wqdx 93 37 to to IN cord-007636-kfd0wqdx 93 38 neural neural JJ cord-007636-kfd0wqdx 93 39 antigens antigen NNS cord-007636-kfd0wqdx 93 40 Monoclonal Monoclonal NNP cord-007636-kfd0wqdx 93 41 antibody antibody NN cord-007636-kfd0wqdx 93 42 analysis analysis NN cord-007636-kfd0wqdx 93 43 of of IN cord-007636-kfd0wqdx 93 44 MHC MHC NNP cord-007636-kfd0wqdx 93 45 expression expression NN cord-007636-kfd0wqdx 93 46 in in IN cord-007636-kfd0wqdx 93 47 human human JJ cord-007636-kfd0wqdx 93 48 brain brain NN cord-007636-kfd0wqdx 93 49 biopsies biopsy NNS cord-007636-kfd0wqdx 93 50 : : : cord-007636-kfd0wqdx 93 51 tissue tissue NN cord-007636-kfd0wqdx 93 52 ranging range VBG cord-007636-kfd0wqdx 93 53 from from IN cord-007636-kfd0wqdx 93 54 ' ' '' cord-007636-kfd0wqdx 93 55 histologically histologically RB cord-007636-kfd0wqdx 93 56 normal normal JJ cord-007636-kfd0wqdx 93 57 ' ' '' cord-007636-kfd0wqdx 93 58 to to IN cord-007636-kfd0wqdx 93 59 that that DT cord-007636-kfd0wqdx 93 60 showing show VBG cord-007636-kfd0wqdx 93 61 different different JJ cord-007636-kfd0wqdx 93 62 levels level NNS cord-007636-kfd0wqdx 93 63 of of IN cord-007636-kfd0wqdx 93 64 glial glial JJ cord-007636-kfd0wqdx 93 65 tumor tumor NN cord-007636-kfd0wqdx 93 66 involvement involvement NN cord-007636-kfd0wqdx 93 67 Interactions interaction NNS cord-007636-kfd0wqdx 93 68 between between IN cord-007636-kfd0wqdx 93 69 leucocytes leucocyte NNS cord-007636-kfd0wqdx 93 70 and and CC cord-007636-kfd0wqdx 93 71 individual individual JJ cord-007636-kfd0wqdx 93 72 brain brain NN cord-007636-kfd0wqdx 93 73 tumor tumor NN cord-007636-kfd0wqdx 93 74 cells cell NNS cord-007636-kfd0wqdx 93 75 in in IN cord-007636-kfd0wqdx 93 76 the the DT cord-007636-kfd0wqdx 93 77 rat rat NN cord-007636-kfd0wqdx 93 78 brain brain NN cord-007636-kfd0wqdx 93 79 Radiation Radiation NNP cord-007636-kfd0wqdx 93 80 immunobiology immunobiology NN cord-007636-kfd0wqdx 93 81 and and CC cord-007636-kfd0wqdx 93 82 immunomodulation immunomodulation NN cord-007636-kfd0wqdx 93 83 Principles Principles NNPS cord-007636-kfd0wqdx 93 84 and and CC cord-007636-kfd0wqdx 93 85 Practice Practice NNP cord-007636-kfd0wqdx 93 86 of of IN cord-007636-kfd0wqdx 93 87 Radiation Radiation NNP cord-007636-kfd0wqdx 93 88 Oncology Oncology NNP cord-007636-kfd0wqdx 93 89 Reactive Reactive NNP cord-007636-kfd0wqdx 93 90 microglia microglia NNS cord-007636-kfd0wqdx 93 91 are be VBP cord-007636-kfd0wqdx 93 92 positive positive JJ cord-007636-kfd0wqdx 93 93 for for IN cord-007636-kfd0wqdx 93 94 HLA HLA NNP cord-007636-kfd0wqdx 93 95 - - HYPH cord-007636-kfd0wqdx 93 96 DR DR NNP cord-007636-kfd0wqdx 93 97 in in IN cord-007636-kfd0wqdx 93 98 the the DT cord-007636-kfd0wqdx 93 99 substantia substantia NN cord-007636-kfd0wqdx 93 100 nigra nigra NN cord-007636-kfd0wqdx 93 101 of of IN cord-007636-kfd0wqdx 93 102 Parkinson Parkinson NNP cord-007636-kfd0wqdx 93 103 's 's POS cord-007636-kfd0wqdx 93 104 and and CC cord-007636-kfd0wqdx 93 105 Alzheimer Alzheimer NNP cord-007636-kfd0wqdx 93 106 's 's POS cord-007636-kfd0wqdx 93 107 disease disease NN cord-007636-kfd0wqdx 93 108 brains brain NNS cord-007636-kfd0wqdx 93 109 y y NNP cord-007636-kfd0wqdx 93 110 - - HYPH cord-007636-kfd0wqdx 93 111 Irradiation Irradiation NNP cord-007636-kfd0wqdx 93 112 facilitates facilitate VBZ cord-007636-kfd0wqdx 93 113 the the DT cord-007636-kfd0wqdx 93 114 expression expression NN cord-007636-kfd0wqdx 93 115 of of IN cord-007636-kfd0wqdx 93 116 adoptive adoptive JJ cord-007636-kfd0wqdx 93 117 immunity immunity NN cord-007636-kfd0wqdx 93 118 against against IN cord-007636-kfd0wqdx 93 119 established establish VBN cord-007636-kfd0wqdx 93 120 tumors tumor NNS cord-007636-kfd0wqdx 93 121 by by IN cord-007636-kfd0wqdx 93 122 eliminating eliminate VBG cord-007636-kfd0wqdx 93 123 suppressor suppressor NN cord-007636-kfd0wqdx 93 124 T T NNP cord-007636-kfd0wqdx 93 125 cells cell NNS cord-007636-kfd0wqdx 93 126 Morphological morphological JJ cord-007636-kfd0wqdx 93 127 studies study NNS cord-007636-kfd0wqdx 93 128 of of IN cord-007636-kfd0wqdx 93 129 rat rat NN cord-007636-kfd0wqdx 93 130 brain brain NN cord-007636-kfd0wqdx 93 131 tumors tumor NNS cord-007636-kfd0wqdx 93 132 induced induce VBN cord-007636-kfd0wqdx 93 133 by by IN cord-007636-kfd0wqdx 93 134 N N NNP cord-007636-kfd0wqdx 93 135 - - HYPH cord-007636-kfd0wqdx 93 136 nitrosomethyhirea nitrosomethyhirea NNP cord-007636-kfd0wqdx 94 1 The the DT cord-007636-kfd0wqdx 94 2 immunopathology immunopathology NN cord-007636-kfd0wqdx 94 3 of of IN cord-007636-kfd0wqdx 94 4 experimental experimental JJ cord-007636-kfd0wqdx 94 5 allergic allergic JJ cord-007636-kfd0wqdx 94 6 encephalomyelitis encephalomyelitis NN cord-007636-kfd0wqdx 94 7 . . . cord-007636-kfd0wqdx 95 1 II II NNP cord-007636-kfd0wqdx 95 2 . . . cord-007636-kfd0wqdx 96 1 Endothelial endothelial JJ cord-007636-kfd0wqdx 96 2 cell cell NN cord-007636-kfd0wqdx 96 3 Ia Ia NNP cord-007636-kfd0wqdx 96 4 increases increase VBZ cord-007636-kfd0wqdx 96 5 prior prior RB cord-007636-kfd0wqdx 96 6 to to IN cord-007636-kfd0wqdx 96 7 inflammatory inflammatory JJ cord-007636-kfd0wqdx 96 8 infiltration infiltration NN cord-007636-kfd0wqdx 96 9 Peripheral peripheral JJ cord-007636-kfd0wqdx 96 10 nerve nerve NN cord-007636-kfd0wqdx 96 11 lesion lesion NN cord-007636-kfd0wqdx 96 12 produces produce VBZ cord-007636-kfd0wqdx 96 13 increased increase VBN cord-007636-kfd0wqdx 96 14 levels level NNS cord-007636-kfd0wqdx 96 15 of of IN cord-007636-kfd0wqdx 96 16 MHC MHC NNP cord-007636-kfd0wqdx 96 17 antigens antigen NNS cord-007636-kfd0wqdx 96 18 in in IN cord-007636-kfd0wqdx 96 19 the the DT cord-007636-kfd0wqdx 96 20 CNS CNS NNP cord-007636-kfd0wqdx 96 21 Corona Corona NNP cord-007636-kfd0wqdx 96 22 virus virus NN cord-007636-kfd0wqdx 96 23 infection infection NN cord-007636-kfd0wqdx 97 1 induces induce VBZ cord-007636-kfd0wqdx 97 2 H-2 H-2 NNP cord-007636-kfd0wqdx 97 3 antigen antigen NN cord-007636-kfd0wqdx 97 4 expression expression NN cord-007636-kfd0wqdx 97 5 in in IN cord-007636-kfd0wqdx 97 6 oligodendrocytes oligodendrocyte NNS cord-007636-kfd0wqdx 97 7 and and CC cord-007636-kfd0wqdx 97 8 astrocytes astrocyte NNS cord-007636-kfd0wqdx 97 9 Reduced reduce VBN cord-007636-kfd0wqdx 97 10 tumor tumor NN cord-007636-kfd0wqdx 97 11 growth growth NN cord-007636-kfd0wqdx 97 12 after after IN cord-007636-kfd0wqdx 97 13 low low JJ cord-007636-kfd0wqdx 97 14 dose dose NN cord-007636-kfd0wqdx 97 15 irradiation irradiation NN cord-007636-kfd0wqdx 97 16 or or CC cord-007636-kfd0wqdx 97 17 immunization immunization NN cord-007636-kfd0wqdx 97 18 against against IN cord-007636-kfd0wqdx 97 19 blastic blastic JJ cord-007636-kfd0wqdx 97 20 suppressor suppressor NN cord-007636-kfd0wqdx 97 21 cells cell NNS cord-007636-kfd0wqdx 98 1 Multiple multiple JJ cord-007636-kfd0wqdx 98 2 sclerosis sclerosis NN cord-007636-kfd0wqdx 98 3 : : : cord-007636-kfd0wqdx 99 1 relevance relevance NN cord-007636-kfd0wqdx 99 2 of of IN cord-007636-kfd0wqdx 99 3 class class NN cord-007636-kfd0wqdx 99 4 I i NN cord-007636-kfd0wqdx 99 5 and and CC cord-007636-kfd0wqdx 99 6 class class NN cord-007636-kfd0wqdx 99 7 II II NNP cord-007636-kfd0wqdx 99 8 MHC MHC NNP cord-007636-kfd0wqdx 99 9 expressing express VBG cord-007636-kfd0wqdx 99 10 cells cell NNS cord-007636-kfd0wqdx 99 11 to to IN cord-007636-kfd0wqdx 99 12 lesion lesion NN cord-007636-kfd0wqdx 99 13 development development NN cord-007636-kfd0wqdx 99 14 HLA HLA NNP cord-007636-kfd0wqdx 99 15 class class NN cord-007636-kfd0wqdx 99 16 1 1 CD cord-007636-kfd0wqdx 99 17 and and CC cord-007636-kfd0wqdx 99 18 fl2-microglobulin fl2-microglobulin JJ cord-007636-kfd0wqdx 99 19 expression expression NN cord-007636-kfd0wqdx 99 20 in in IN cord-007636-kfd0wqdx 99 21 frozen frozen JJ cord-007636-kfd0wqdx 99 22 and and CC cord-007636-kfd0wqdx 99 23 formaldehyde formaldehyde NN cord-007636-kfd0wqdx 99 24 - - HYPH cord-007636-kfd0wqdx 99 25 fixed fix VBN cord-007636-kfd0wqdx 99 26 paraffin paraffin NN cord-007636-kfd0wqdx 99 27 sections section NNS cord-007636-kfd0wqdx 99 28 of of IN cord-007636-kfd0wqdx 99 29 neuroblastoma neuroblastoma NN cord-007636-kfd0wqdx 99 30 tumors tumor NNS cord-007636-kfd0wqdx 99 31 Distribution distribution NN cord-007636-kfd0wqdx 99 32 of of IN cord-007636-kfd0wqdx 99 33 fl2-microglobulin fl2-microglobulin NNP cord-007636-kfd0wqdx 99 34 in in IN cord-007636-kfd0wqdx 99 35 olfactory olfactory JJ cord-007636-kfd0wqdx 99 36 epithelium epithelium NN cord-007636-kfd0wqdx 99 37 : : : cord-007636-kfd0wqdx 99 38 a a DT cord-007636-kfd0wqdx 99 39 proliferating proliferate VBG cord-007636-kfd0wqdx 99 40 neuroepithelium neuroepithelium NNP cord-007636-kfd0wqdx 99 41 not not RB cord-007636-kfd0wqdx 99 42 protected protect VBN cord-007636-kfd0wqdx 99 43 by by IN cord-007636-kfd0wqdx 99 44 a a DT cord-007636-kfd0wqdx 99 45 blood blood NN cord-007636-kfd0wqdx 99 46 - - HYPH cord-007636-kfd0wqdx 99 47 tissue tissue NN cord-007636-kfd0wqdx 99 48 barrier barrier NN cord-007636-kfd0wqdx 99 49 Interferon- Interferon- NNP cord-007636-kfd0wqdx 99 50 ) ) -RRB- cord-007636-kfd0wqdx 99 51 , , , cord-007636-kfd0wqdx 99 52 induces induce VBZ cord-007636-kfd0wqdx 99 53 the the DT cord-007636-kfd0wqdx 99 54 expression expression NN cord-007636-kfd0wqdx 99 55 of of IN cord-007636-kfd0wqdx 99 56 H-2 H-2 NNP cord-007636-kfd0wqdx 99 57 and and CC cord-007636-kfd0wqdx 99 58 la la NNP cord-007636-kfd0wqdx 99 59 antigens antigen NNS cord-007636-kfd0wqdx 99 60 on on IN cord-007636-kfd0wqdx 99 61 brain brain NN cord-007636-kfd0wqdx 99 62 cells cell NNS