id sid tid token lemma pos cord-013590-pkm81fq1 1 1 key key JJ cord-013590-pkm81fq1 2 1 : : : cord-013590-pkm81fq1 2 2 cord-013590-pkm81fq1 cord-013590-pkm81fq1 NNP cord-013590-pkm81fq1 2 3 authors author NNS cord-013590-pkm81fq1 2 4 : : : cord-013590-pkm81fq1 2 5 Deseke Deseke NNP cord-013590-pkm81fq1 2 6 , , , cord-013590-pkm81fq1 2 7 Malte Malte NNP cord-013590-pkm81fq1 2 8 ; ; : cord-013590-pkm81fq1 2 9 Prinz Prinz NNP cord-013590-pkm81fq1 2 10 , , , cord-013590-pkm81fq1 2 11 Immo Immo NNP cord-013590-pkm81fq1 2 12 title title NN cord-013590-pkm81fq1 2 13 : : : cord-013590-pkm81fq1 3 1 Ligand ligand NN cord-013590-pkm81fq1 3 2 recognition recognition NN cord-013590-pkm81fq1 3 3 by by IN cord-013590-pkm81fq1 3 4 the the DT cord-013590-pkm81fq1 3 5 γδ γδ NNP cord-013590-pkm81fq1 3 6 TCR TCR NNP cord-013590-pkm81fq1 3 7 and and CC cord-013590-pkm81fq1 3 8 discrimination discrimination NN cord-013590-pkm81fq1 3 9 between between IN cord-013590-pkm81fq1 3 10 homeostasis homeostasis NN cord-013590-pkm81fq1 3 11 and and CC cord-013590-pkm81fq1 3 12 stress stress NN cord-013590-pkm81fq1 3 13 conditions condition NNS cord-013590-pkm81fq1 3 14 date date NN cord-013590-pkm81fq1 3 15 : : : cord-013590-pkm81fq1 3 16 2020 2020 CD cord-013590-pkm81fq1 3 17 - - HYPH cord-013590-pkm81fq1 3 18 07 07 CD cord-013590-pkm81fq1 3 19 - - HYPH cord-013590-pkm81fq1 3 20 24 24 CD cord-013590-pkm81fq1 3 21 journal journal NN cord-013590-pkm81fq1 3 22 : : : cord-013590-pkm81fq1 4 1 Cell cell NN cord-013590-pkm81fq1 4 2 Mol Mol NNP cord-013590-pkm81fq1 4 3 Immunol Immunol NNP cord-013590-pkm81fq1 5 1 DOI DOI NNP cord-013590-pkm81fq1 6 1 : : : cord-013590-pkm81fq1 6 2 10.1038 10.1038 CD cord-013590-pkm81fq1 6 3 / / SYM cord-013590-pkm81fq1 6 4 s41423 s41423 NNP cord-013590-pkm81fq1 6 5 - - HYPH cord-013590-pkm81fq1 6 6 020 020 CD cord-013590-pkm81fq1 6 7 - - HYPH cord-013590-pkm81fq1 6 8 0503-y 0503-y CD cord-013590-pkm81fq1 6 9 sha sha NNP cord-013590-pkm81fq1 6 10 : : : cord-013590-pkm81fq1 6 11 69c7447e591e2a88602467efedb4956d6998cd28 69c7447e591e2a88602467efedb4956d6998cd28 NNP cord-013590-pkm81fq1 6 12 doc_id doc_id CD cord-013590-pkm81fq1 6 13 : : : cord-013590-pkm81fq1 6 14 13590 13590 CD cord-013590-pkm81fq1 6 15 cord_uid cord_uid NNS cord-013590-pkm81fq1 6 16 : : : cord-013590-pkm81fq1 7 1 pkm81fq1 pkm81fq1 NNP cord-013590-pkm81fq1 7 2 T T NNP cord-013590-pkm81fq1 7 3 lymphocytes lymphocyte NNS cord-013590-pkm81fq1 7 4 comprise comprise VBP cord-013590-pkm81fq1 7 5 cells cell NNS cord-013590-pkm81fq1 7 6 expressing express VBG cord-013590-pkm81fq1 7 7 either either CC cord-013590-pkm81fq1 7 8 an an DT cord-013590-pkm81fq1 7 9 αβ αβ NN cord-013590-pkm81fq1 7 10 or or CC cord-013590-pkm81fq1 7 11 a a DT cord-013590-pkm81fq1 7 12 γδ γδ NN cord-013590-pkm81fq1 7 13 TCR TCR NNP cord-013590-pkm81fq1 7 14 . . . cord-013590-pkm81fq1 8 1 The the DT cord-013590-pkm81fq1 8 2 riddle riddle NN cord-013590-pkm81fq1 8 3 how how WRB cord-013590-pkm81fq1 8 4 αβ αβ FW cord-013590-pkm81fq1 8 5 TCRs tcr NNS cord-013590-pkm81fq1 8 6 are be VBP cord-013590-pkm81fq1 8 7 triggered trigger VBN cord-013590-pkm81fq1 8 8 by by IN cord-013590-pkm81fq1 8 9 specific specific JJ cord-013590-pkm81fq1 8 10 peptides peptide NNS cord-013590-pkm81fq1 8 11 presented present VBN cord-013590-pkm81fq1 8 12 in in IN cord-013590-pkm81fq1 8 13 the the DT cord-013590-pkm81fq1 8 14 context context NN cord-013590-pkm81fq1 8 15 of of IN cord-013590-pkm81fq1 8 16 MHC MHC NNP cord-013590-pkm81fq1 8 17 was be VBD cord-013590-pkm81fq1 8 18 elucidated elucidate VBN cord-013590-pkm81fq1 8 19 some some DT cord-013590-pkm81fq1 8 20 time time NN cord-013590-pkm81fq1 8 21 ago ago RB cord-013590-pkm81fq1 8 22 . . . cord-013590-pkm81fq1 9 1 In in IN cord-013590-pkm81fq1 9 2 contrast contrast NN cord-013590-pkm81fq1 9 3 , , , cord-013590-pkm81fq1 9 4 the the DT cord-013590-pkm81fq1 9 5 mechanisms mechanism NNS cord-013590-pkm81fq1 9 6 that that WDT cord-013590-pkm81fq1 9 7 underlie underlie VBP cord-013590-pkm81fq1 9 8 antigen antigen NN cord-013590-pkm81fq1 9 9 recognition recognition NN cord-013590-pkm81fq1 9 10 by by IN cord-013590-pkm81fq1 9 11 γδ γδ IN cord-013590-pkm81fq1 9 12 TCRs tcr NNS cord-013590-pkm81fq1 9 13 are be VBP cord-013590-pkm81fq1 9 14 still still RB cord-013590-pkm81fq1 9 15 baffling baffle VBG cord-013590-pkm81fq1 9 16 the the DT cord-013590-pkm81fq1 9 17 scientific scientific JJ cord-013590-pkm81fq1 9 18 community community NN cord-013590-pkm81fq1 9 19 . . . cord-013590-pkm81fq1 10 1 It -PRON- PRP cord-013590-pkm81fq1 10 2 is be VBZ cord-013590-pkm81fq1 10 3 clear clear JJ cord-013590-pkm81fq1 10 4 that that IN cord-013590-pkm81fq1 10 5 activation activation NN cord-013590-pkm81fq1 10 6 of of IN cord-013590-pkm81fq1 10 7 γδ γδ NNP cord-013590-pkm81fq1 10 8 TCRs TCRs NNP cord-013590-pkm81fq1 10 9 does do VBZ cord-013590-pkm81fq1 10 10 not not RB cord-013590-pkm81fq1 10 11 necessarily necessarily RB cord-013590-pkm81fq1 10 12 depend depend VB cord-013590-pkm81fq1 10 13 on on IN cord-013590-pkm81fq1 10 14 MHC MHC NNP cord-013590-pkm81fq1 10 15 antigen antigen NN cord-013590-pkm81fq1 10 16 presentation presentation NN cord-013590-pkm81fq1 10 17 . . . cord-013590-pkm81fq1 11 1 To to IN cord-013590-pkm81fq1 11 2 date date NN cord-013590-pkm81fq1 11 3 , , , cord-013590-pkm81fq1 11 4 diverse diverse JJ cord-013590-pkm81fq1 11 5 and and CC cord-013590-pkm81fq1 11 6 largely largely RB cord-013590-pkm81fq1 11 7 host host NN cord-013590-pkm81fq1 11 8 - - HYPH cord-013590-pkm81fq1 11 9 cell cell NN cord-013590-pkm81fq1 11 10 - - HYPH cord-013590-pkm81fq1 11 11 derived derive VBN cord-013590-pkm81fq1 11 12 molecules molecule NNS cord-013590-pkm81fq1 11 13 have have VBP cord-013590-pkm81fq1 11 14 been be VBN cord-013590-pkm81fq1 11 15 identified identify VBN cord-013590-pkm81fq1 11 16 as as IN cord-013590-pkm81fq1 11 17 cognate cognate JJ cord-013590-pkm81fq1 11 18 antigens antigen NNS cord-013590-pkm81fq1 11 19 for for IN cord-013590-pkm81fq1 11 20 the the DT cord-013590-pkm81fq1 11 21 γδ γδ NNP cord-013590-pkm81fq1 11 22 TCR TCR NNP cord-013590-pkm81fq1 11 23 . . . cord-013590-pkm81fq1 12 1 However however RB cord-013590-pkm81fq1 12 2 , , , cord-013590-pkm81fq1 12 3 for for IN cord-013590-pkm81fq1 12 4 most most JJS cord-013590-pkm81fq1 12 5 γδ γδ IN cord-013590-pkm81fq1 12 6 TCRs TCRs NNP cord-013590-pkm81fq1 12 7 , , , cord-013590-pkm81fq1 12 8 the the DT cord-013590-pkm81fq1 12 9 activating activate VBG cord-013590-pkm81fq1 12 10 ligand ligand NN cord-013590-pkm81fq1 12 11 is be VBZ cord-013590-pkm81fq1 12 12 still still RB cord-013590-pkm81fq1 12 13 unknown unknown JJ cord-013590-pkm81fq1 12 14 and and CC cord-013590-pkm81fq1 12 15 many many JJ cord-013590-pkm81fq1 12 16 open open JJ cord-013590-pkm81fq1 12 17 questions question NNS cord-013590-pkm81fq1 12 18 with with IN cord-013590-pkm81fq1 12 19 regard regard NN cord-013590-pkm81fq1 12 20 to to IN cord-013590-pkm81fq1 12 21 physiological physiological JJ cord-013590-pkm81fq1 12 22 relevance relevance NN cord-013590-pkm81fq1 12 23 and and CC cord-013590-pkm81fq1 12 24 generalizable generalizable JJ cord-013590-pkm81fq1 12 25 concepts concept NNS cord-013590-pkm81fq1 12 26 remain remain VBP cord-013590-pkm81fq1 12 27 . . . cord-013590-pkm81fq1 13 1 Especially especially RB cord-013590-pkm81fq1 13 2 the the DT cord-013590-pkm81fq1 13 3 question question NN cord-013590-pkm81fq1 13 4 of of IN cord-013590-pkm81fq1 13 5 how how WRB cord-013590-pkm81fq1 13 6 γδ γδ NNP cord-013590-pkm81fq1 13 7 T t NN cord-013590-pkm81fq1 13 8 cells cell NNS cord-013590-pkm81fq1 13 9 can can MD cord-013590-pkm81fq1 13 10 distinguish distinguish VB cord-013590-pkm81fq1 13 11 homeostatic homeostatic JJ cord-013590-pkm81fq1 13 12 from from IN cord-013590-pkm81fq1 13 13 stress stress NN cord-013590-pkm81fq1 13 14 conditions condition NNS cord-013590-pkm81fq1 13 15 via via IN cord-013590-pkm81fq1 13 16 their -PRON- PRP$ cord-013590-pkm81fq1 13 17 TCR TCR NNP cord-013590-pkm81fq1 13 18 remains remain VBZ cord-013590-pkm81fq1 13 19 largely largely RB cord-013590-pkm81fq1 13 20 unresolved unresolved JJ cord-013590-pkm81fq1 13 21 . . . cord-013590-pkm81fq1 14 1 Recent recent JJ cord-013590-pkm81fq1 14 2 discoveries discovery NNS cord-013590-pkm81fq1 14 3 in in IN cord-013590-pkm81fq1 14 4 the the DT cord-013590-pkm81fq1 14 5 field field NN cord-013590-pkm81fq1 14 6 might may MD cord-013590-pkm81fq1 14 7 have have VB cord-013590-pkm81fq1 14 8 paved pave VBN cord-013590-pkm81fq1 14 9 the the DT cord-013590-pkm81fq1 14 10 way way NN cord-013590-pkm81fq1 14 11 towards towards IN cord-013590-pkm81fq1 14 12 a a DT cord-013590-pkm81fq1 14 13 better well JJR cord-013590-pkm81fq1 14 14 understanding understanding NN cord-013590-pkm81fq1 14 15 of of IN cord-013590-pkm81fq1 14 16 antigen antigen NN cord-013590-pkm81fq1 14 17 recognition recognition NN cord-013590-pkm81fq1 14 18 by by IN cord-013590-pkm81fq1 14 19 the the DT cord-013590-pkm81fq1 14 20 γδ γδ NNP cord-013590-pkm81fq1 14 21 TCR TCR NNP cord-013590-pkm81fq1 14 22 and and CC cord-013590-pkm81fq1 14 23 have have VBP cord-013590-pkm81fq1 14 24 made make VBN cord-013590-pkm81fq1 14 25 it -PRON- PRP cord-013590-pkm81fq1 14 26 conceivable conceivable JJ cord-013590-pkm81fq1 14 27 to to TO cord-013590-pkm81fq1 14 28 revise revise VB cord-013590-pkm81fq1 14 29 the the DT cord-013590-pkm81fq1 14 30 current current JJ cord-013590-pkm81fq1 14 31 knowledge knowledge NN cord-013590-pkm81fq1 14 32 and and CC cord-013590-pkm81fq1 14 33 contextualize contextualize VB cord-013590-pkm81fq1 14 34 the the DT cord-013590-pkm81fq1 14 35 new new JJ cord-013590-pkm81fq1 14 36 findings finding NNS cord-013590-pkm81fq1 14 37 . . . cord-013590-pkm81fq1 15 1 T t NN cord-013590-pkm81fq1 15 2 cells cell NNS cord-013590-pkm81fq1 15 3 are be VBP cord-013590-pkm81fq1 15 4 divided divide VBN cord-013590-pkm81fq1 15 5 into into IN cord-013590-pkm81fq1 15 6 αβ αβ NN cord-013590-pkm81fq1 15 7 and and CC cord-013590-pkm81fq1 15 8 γδ γδ NN cord-013590-pkm81fq1 15 9 T t NN cord-013590-pkm81fq1 15 10 cells cell NNS cord-013590-pkm81fq1 15 11 based base VBN cord-013590-pkm81fq1 15 12 on on IN cord-013590-pkm81fq1 15 13 the the DT cord-013590-pkm81fq1 15 14 expression expression NN cord-013590-pkm81fq1 15 15 of of IN cord-013590-pkm81fq1 15 16 their -PRON- PRP$ cord-013590-pkm81fq1 15 17 respective respective JJ cord-013590-pkm81fq1 15 18 T t NN cord-013590-pkm81fq1 15 19 - - HYPH cord-013590-pkm81fq1 15 20 cell cell NN cord-013590-pkm81fq1 15 21 receptor receptor NN cord-013590-pkm81fq1 15 22 ( ( -LRB- cord-013590-pkm81fq1 15 23 TCR TCR NNP cord-013590-pkm81fq1 15 24 ) ) -RRB- cord-013590-pkm81fq1 15 25 . . . cord-013590-pkm81fq1 16 1 With with IN cord-013590-pkm81fq1 16 2 a a DT cord-013590-pkm81fq1 16 3 frequency frequency NN cord-013590-pkm81fq1 16 4 of of IN cord-013590-pkm81fq1 16 5 0.5 0.5 CD cord-013590-pkm81fq1 16 6 - - SYM cord-013590-pkm81fq1 16 7 16 16 CD cord-013590-pkm81fq1 16 8 % % NN cord-013590-pkm81fq1 16 9 of of IN cord-013590-pkm81fq1 16 10 all all DT cord-013590-pkm81fq1 16 11 T t NN cord-013590-pkm81fq1 16 12 cells cell NNS cord-013590-pkm81fq1 16 13 in in IN cord-013590-pkm81fq1 16 14 human human JJ cord-013590-pkm81fq1 16 15 peripheral peripheral JJ cord-013590-pkm81fq1 16 16 blood blood NN cord-013590-pkm81fq1 16 17 γδ γδ NN cord-013590-pkm81fq1 16 18 T t NN cord-013590-pkm81fq1 16 19 cells cell NNS cord-013590-pkm81fq1 16 20 are be VBP cord-013590-pkm81fq1 16 21 the the DT cord-013590-pkm81fq1 16 22 smaller smaller RBR cord-013590-pkm81fq1 16 23 subset subset JJ cord-013590-pkm81fq1 16 24 although although IN cord-013590-pkm81fq1 16 25 higher high JJR cord-013590-pkm81fq1 16 26 abundances abundance NNS cord-013590-pkm81fq1 16 27 can can MD cord-013590-pkm81fq1 16 28 be be VB cord-013590-pkm81fq1 16 29 observed observe VBN cord-013590-pkm81fq1 16 30 in in IN cord-013590-pkm81fq1 16 31 peripheral peripheral JJ cord-013590-pkm81fq1 16 32 tissues tissue NNS cord-013590-pkm81fq1 16 33 . . . cord-013590-pkm81fq1 17 1 1 1 CD cord-013590-pkm81fq1 17 2 , , , cord-013590-pkm81fq1 17 3 2 2 CD cord-013590-pkm81fq1 18 1 Nevertheless nevertheless RB cord-013590-pkm81fq1 18 2 , , , cord-013590-pkm81fq1 18 3 this this DT cord-013590-pkm81fq1 18 4 enigmatic enigmatic JJ cord-013590-pkm81fq1 18 5 immune immune JJ cord-013590-pkm81fq1 18 6 cell cell NN cord-013590-pkm81fq1 18 7 subset subset NN cord-013590-pkm81fq1 18 8 is be VBZ cord-013590-pkm81fq1 18 9 conserved conserve VBN cord-013590-pkm81fq1 18 10 among among IN cord-013590-pkm81fq1 18 11 almost almost RB cord-013590-pkm81fq1 18 12 all all DT cord-013590-pkm81fq1 18 13 jawed jawed JJ cord-013590-pkm81fq1 18 14 vertebrates vertebrate NNS cord-013590-pkm81fq1 18 15 , , , cord-013590-pkm81fq1 18 16 which which WDT cord-013590-pkm81fq1 18 17 indicates indicate VBZ cord-013590-pkm81fq1 18 18 their -PRON- PRP$ cord-013590-pkm81fq1 18 19 importance importance NN cord-013590-pkm81fq1 18 20 for for IN cord-013590-pkm81fq1 18 21 the the DT cord-013590-pkm81fq1 18 22 immune immune JJ cord-013590-pkm81fq1 18 23 system system NN cord-013590-pkm81fq1 18 24 . . . cord-013590-pkm81fq1 19 1 They -PRON- PRP cord-013590-pkm81fq1 19 2 are be VBP cord-013590-pkm81fq1 19 3 able able JJ cord-013590-pkm81fq1 19 4 to to TO cord-013590-pkm81fq1 19 5 recognize recognize VB cord-013590-pkm81fq1 19 6 a a DT cord-013590-pkm81fq1 19 7 plethora plethora NN cord-013590-pkm81fq1 19 8 of of IN cord-013590-pkm81fq1 19 9 infections infection NNS cord-013590-pkm81fq1 19 10 such such JJ cord-013590-pkm81fq1 19 11 as as IN cord-013590-pkm81fq1 19 12 by by IN cord-013590-pkm81fq1 19 13 mycobacteria mycobacterium NNS cord-013590-pkm81fq1 19 14 , , , cord-013590-pkm81fq1 19 15 3 3 CD cord-013590-pkm81fq1 19 16 Plasmodium Plasmodium NNP cord-013590-pkm81fq1 19 17 , , , cord-013590-pkm81fq1 19 18 4,5 4,5 CD cord-013590-pkm81fq1 19 19 or or CC cord-013590-pkm81fq1 19 20 cytomegalovirus cytomegalovirus NNP cord-013590-pkm81fq1 19 21 ( ( -LRB- cord-013590-pkm81fq1 19 22 CMV CMV NNP cord-013590-pkm81fq1 19 23 ) ) -RRB- cord-013590-pkm81fq1 19 24 6 6 CD cord-013590-pkm81fq1 19 25 and and CC cord-013590-pkm81fq1 19 26 induce induce VB cord-013590-pkm81fq1 19 27 potent potent JJ cord-013590-pkm81fq1 19 28 infection infection NN cord-013590-pkm81fq1 19 29 containing contain VBG cord-013590-pkm81fq1 19 30 reactions reaction NNS cord-013590-pkm81fq1 19 31 , , , cord-013590-pkm81fq1 19 32 such such JJ cord-013590-pkm81fq1 19 33 as as IN cord-013590-pkm81fq1 19 34 granzyme granzyme NNS cord-013590-pkm81fq1 19 35 and and CC cord-013590-pkm81fq1 19 36 cytokine cytokine NN cord-013590-pkm81fq1 19 37 release release NN cord-013590-pkm81fq1 19 38 . . . cord-013590-pkm81fq1 20 1 7 7 CD cord-013590-pkm81fq1 20 2 , , , cord-013590-pkm81fq1 20 3 8 8 CD cord-013590-pkm81fq1 21 1 Besides besides RB cord-013590-pkm81fq1 21 2 , , , cord-013590-pkm81fq1 21 3 γδ γδ CC cord-013590-pkm81fq1 21 4 T t NN cord-013590-pkm81fq1 21 5 cells cell NNS cord-013590-pkm81fq1 21 6 were be VBD cord-013590-pkm81fq1 21 7 also also RB cord-013590-pkm81fq1 21 8 shown show VBN cord-013590-pkm81fq1 21 9 to to TO cord-013590-pkm81fq1 21 10 be be VB cord-013590-pkm81fq1 21 11 effective effective JJ cord-013590-pkm81fq1 21 12 in in IN cord-013590-pkm81fq1 21 13 inducing induce VBG cord-013590-pkm81fq1 21 14 antitumor antitumor JJ cord-013590-pkm81fq1 21 15 responses response NNS cord-013590-pkm81fq1 21 16 . . . cord-013590-pkm81fq1 22 1 [ [ -LRB- cord-013590-pkm81fq1 22 2 9 9 CD cord-013590-pkm81fq1 22 3 ] ] -RRB- cord-013590-pkm81fq1 22 4 [ [ -LRB- cord-013590-pkm81fq1 22 5 10 10 CD cord-013590-pkm81fq1 22 6 ] ] -RRB- cord-013590-pkm81fq1 23 1 [ [ -LRB- cord-013590-pkm81fq1 23 2 11 11 CD cord-013590-pkm81fq1 23 3 ] ] -RRB- cord-013590-pkm81fq1 24 1 Besides besides IN cord-013590-pkm81fq1 24 2 the the DT cord-013590-pkm81fq1 24 3 different different JJ cord-013590-pkm81fq1 24 4 immune immune JJ cord-013590-pkm81fq1 24 5 receptors receptor NNS cord-013590-pkm81fq1 24 6 expressed express VBN cord-013590-pkm81fq1 24 7 by by IN cord-013590-pkm81fq1 24 8 γδ γδ NNP cord-013590-pkm81fq1 24 9 T T NNP cord-013590-pkm81fq1 24 10 cells cell NNS cord-013590-pkm81fq1 24 11 like like IN cord-013590-pkm81fq1 24 12 NK NK NNP cord-013590-pkm81fq1 24 13 cell cell NN cord-013590-pkm81fq1 24 14 receptors receptor NNS cord-013590-pkm81fq1 24 15 and and CC cord-013590-pkm81fq1 24 16 NCRs ncr NNS cord-013590-pkm81fq1 24 17 , , , cord-013590-pkm81fq1 24 18 their -PRON- PRP$ cord-013590-pkm81fq1 24 19 TCR TCR NNP cord-013590-pkm81fq1 24 20 is be VBZ cord-013590-pkm81fq1 24 21 one one CD cord-013590-pkm81fq1 24 22 of of IN cord-013590-pkm81fq1 24 23 the the DT cord-013590-pkm81fq1 24 24 main main JJ cord-013590-pkm81fq1 24 25 cellsurface cellsurface NN cord-013590-pkm81fq1 24 26 molecules molecule NNS cord-013590-pkm81fq1 24 27 that that WDT cord-013590-pkm81fq1 24 28 is be VBZ cord-013590-pkm81fq1 24 29 involved involve VBN cord-013590-pkm81fq1 24 30 in in IN cord-013590-pkm81fq1 24 31 the the DT cord-013590-pkm81fq1 24 32 recognition recognition NN cord-013590-pkm81fq1 24 33 of of IN cord-013590-pkm81fq1 24 34 pathological pathological JJ cord-013590-pkm81fq1 24 35 conditions condition NNS cord-013590-pkm81fq1 24 36 . . . cord-013590-pkm81fq1 25 1 This this DT cord-013590-pkm81fq1 25 2 assumption assumption NN cord-013590-pkm81fq1 25 3 is be VBZ cord-013590-pkm81fq1 25 4 supported support VBN cord-013590-pkm81fq1 25 5 by by IN cord-013590-pkm81fq1 25 6 blocking block VBG cord-013590-pkm81fq1 25 7 experiments experiment NNS cord-013590-pkm81fq1 25 8 12 12 CD cord-013590-pkm81fq1 25 9 , , , cord-013590-pkm81fq1 25 10 13 13 CD cord-013590-pkm81fq1 25 11 and and CC cord-013590-pkm81fq1 25 12 by by IN cord-013590-pkm81fq1 25 13 the the DT cord-013590-pkm81fq1 25 14 clonal clonal JJ cord-013590-pkm81fq1 25 15 expansion expansion NN cord-013590-pkm81fq1 25 16 of of IN cord-013590-pkm81fq1 25 17 specific specific JJ cord-013590-pkm81fq1 25 18 γδ γδ IN cord-013590-pkm81fq1 25 19 TCRs tcr NNS cord-013590-pkm81fq1 25 20 upon upon IN cord-013590-pkm81fq1 25 21 infections infection NNS cord-013590-pkm81fq1 25 22 . . . cord-013590-pkm81fq1 26 1 14 14 CD cord-013590-pkm81fq1 26 2 , , , cord-013590-pkm81fq1 26 3 15 15 CD cord-013590-pkm81fq1 26 4 Like like IN cord-013590-pkm81fq1 26 5 its -PRON- PRP$ cord-013590-pkm81fq1 26 6 αβ αβ NN cord-013590-pkm81fq1 26 7 counterpart counterpart NN cord-013590-pkm81fq1 26 8 , , , cord-013590-pkm81fq1 26 9 the the DT cord-013590-pkm81fq1 26 10 γδ γδ IN cord-013590-pkm81fq1 26 11 TCR TCR NNP cord-013590-pkm81fq1 26 12 is be VBZ cord-013590-pkm81fq1 26 13 composed compose VBN cord-013590-pkm81fq1 26 14 of of IN cord-013590-pkm81fq1 26 15 two two CD cord-013590-pkm81fq1 26 16 chains chain NNS cord-013590-pkm81fq1 26 17 , , , cord-013590-pkm81fq1 26 18 named name VBN cord-013590-pkm81fq1 26 19 gamma gamma NN cord-013590-pkm81fq1 26 20 and and CC cord-013590-pkm81fq1 26 21 delta delta NN cord-013590-pkm81fq1 26 22 , , , cord-013590-pkm81fq1 26 23 whose whose WP$ cord-013590-pkm81fq1 26 24 diversity diversity NN cord-013590-pkm81fq1 26 25 is be VBZ cord-013590-pkm81fq1 26 26 generated generate VBN cord-013590-pkm81fq1 26 27 by by IN cord-013590-pkm81fq1 26 28 the the DT cord-013590-pkm81fq1 26 29 recombination recombination NN cord-013590-pkm81fq1 26 30 of of IN cord-013590-pkm81fq1 26 31 variable variable NN cord-013590-pkm81fq1 26 32 ( ( -LRB- cord-013590-pkm81fq1 26 33 V v NN cord-013590-pkm81fq1 26 34 ) ) -RRB- cord-013590-pkm81fq1 26 35 , , , cord-013590-pkm81fq1 26 36 diversity diversity NN cord-013590-pkm81fq1 26 37 ( ( -LRB- cord-013590-pkm81fq1 26 38 D D NNP cord-013590-pkm81fq1 26 39 , , , cord-013590-pkm81fq1 26 40 only only RB cord-013590-pkm81fq1 26 41 in in IN cord-013590-pkm81fq1 26 42 δ δ NN cord-013590-pkm81fq1 26 43 - - HYPH cord-013590-pkm81fq1 26 44 chain chain NN cord-013590-pkm81fq1 26 45 ) ) -RRB- cord-013590-pkm81fq1 26 46 and and CC cord-013590-pkm81fq1 26 47 joining join VBG cord-013590-pkm81fq1 26 48 ( ( -LRB- cord-013590-pkm81fq1 26 49 J J NNP cord-013590-pkm81fq1 26 50 ) ) -RRB- cord-013590-pkm81fq1 26 51 fragments fragment NNS cord-013590-pkm81fq1 26 52 . . . cord-013590-pkm81fq1 27 1 With with IN cord-013590-pkm81fq1 27 2 some some DT cord-013590-pkm81fq1 27 3 exceptions exception NNS cord-013590-pkm81fq1 27 4 in in IN cord-013590-pkm81fq1 27 5 sharks shark NNS cord-013590-pkm81fq1 27 6 , , , cord-013590-pkm81fq1 27 7 16 16 CD cord-013590-pkm81fq1 27 8 somatic somatic JJ cord-013590-pkm81fq1 27 9 hypermutation hypermutation NN cord-013590-pkm81fq1 27 10 as as IN cord-013590-pkm81fq1 27 11 in in IN cord-013590-pkm81fq1 27 12 immunoglobulin immunoglobulin NN cord-013590-pkm81fq1 27 13 genes gene NNS cord-013590-pkm81fq1 27 14 does do VBZ cord-013590-pkm81fq1 27 15 not not RB cord-013590-pkm81fq1 27 16 occur occur VB cord-013590-pkm81fq1 27 17 in in IN cord-013590-pkm81fq1 27 18 TCRs tcr NNS cord-013590-pkm81fq1 27 19 so so IN cord-013590-pkm81fq1 27 20 that that IN cord-013590-pkm81fq1 27 21 the the DT cord-013590-pkm81fq1 27 22 recombined recombine VBN cord-013590-pkm81fq1 27 23 region region NN cord-013590-pkm81fq1 27 24 , , , cord-013590-pkm81fq1 27 25 which which WDT cord-013590-pkm81fq1 27 26 makes make VBZ cord-013590-pkm81fq1 27 27 up up RP cord-013590-pkm81fq1 27 28 the the DT cord-013590-pkm81fq1 27 29 complementarity complementarity NN cord-013590-pkm81fq1 27 30 defining define VBG cord-013590-pkm81fq1 27 31 region region NN cord-013590-pkm81fq1 27 32 3 3 CD cord-013590-pkm81fq1 27 33 ( ( -LRB- cord-013590-pkm81fq1 27 34 CDR3 CDR3 NNP cord-013590-pkm81fq1 27 35 ) ) -RRB- cord-013590-pkm81fq1 27 36 , , , cord-013590-pkm81fq1 27 37 comprises comprise VBZ cord-013590-pkm81fq1 27 38 most most JJS cord-013590-pkm81fq1 27 39 of of IN cord-013590-pkm81fq1 27 40 the the DT cord-013590-pkm81fq1 27 41 receptor receptor NN cord-013590-pkm81fq1 27 42 's 's POS cord-013590-pkm81fq1 27 43 diversity diversity NN cord-013590-pkm81fq1 27 44 . . . cord-013590-pkm81fq1 28 1 The the DT cord-013590-pkm81fq1 28 2 recognition recognition NN cord-013590-pkm81fq1 28 3 of of IN cord-013590-pkm81fq1 28 4 antigens antigen NNS cord-013590-pkm81fq1 28 5 , , , cord-013590-pkm81fq1 28 6 however however RB cord-013590-pkm81fq1 28 7 , , , cord-013590-pkm81fq1 28 8 seems seem VBZ cord-013590-pkm81fq1 28 9 to to TO cord-013590-pkm81fq1 28 10 be be VB cord-013590-pkm81fq1 28 11 entirely entirely RB cord-013590-pkm81fq1 28 12 different different JJ cord-013590-pkm81fq1 28 13 when when WRB cord-013590-pkm81fq1 28 14 compared compare VBN cord-013590-pkm81fq1 28 15 between between IN cord-013590-pkm81fq1 28 16 αβ αβ NN cord-013590-pkm81fq1 28 17 and and CC cord-013590-pkm81fq1 28 18 γδ γδ IN cord-013590-pkm81fq1 28 19 TCRs tcr NNS cord-013590-pkm81fq1 28 20 . . . cord-013590-pkm81fq1 29 1 Most Most JJS cord-013590-pkm81fq1 29 2 αβ αβ PRP$ cord-013590-pkm81fq1 29 3 TCRs tcr NNS cord-013590-pkm81fq1 29 4 bind bind VB cord-013590-pkm81fq1 29 5 to to IN cord-013590-pkm81fq1 29 6 major major JJ cord-013590-pkm81fq1 29 7 histocompatibility histocompatibility NN cord-013590-pkm81fq1 29 8 complexes complex NNS cord-013590-pkm81fq1 29 9 ( ( -LRB- cord-013590-pkm81fq1 29 10 MHC MHC NNP cord-013590-pkm81fq1 29 11 ) ) -RRB- cord-013590-pkm81fq1 30 1 I -PRON- PRP cord-013590-pkm81fq1 30 2 or or CC cord-013590-pkm81fq1 30 3 II II NNP cord-013590-pkm81fq1 30 4 presenting present VBG cord-013590-pkm81fq1 30 5 small small JJ cord-013590-pkm81fq1 30 6 peptide peptide NN cord-013590-pkm81fq1 30 7 fragments fragment NNS cord-013590-pkm81fq1 30 8 derived derive VBN cord-013590-pkm81fq1 30 9 from from IN cord-013590-pkm81fq1 30 10 pathogens pathogen NNS cord-013590-pkm81fq1 30 11 or or CC cord-013590-pkm81fq1 30 12 tumor tumor NN cord-013590-pkm81fq1 30 13 specific specific JJ cord-013590-pkm81fq1 30 14 proteins protein NNS cord-013590-pkm81fq1 30 15 . . . cord-013590-pkm81fq1 31 1 Together together RB cord-013590-pkm81fq1 31 2 with with IN cord-013590-pkm81fq1 31 3 co co JJ cord-013590-pkm81fq1 31 4 - - JJ cord-013590-pkm81fq1 31 5 receptor receptor JJ cord-013590-pkm81fq1 31 6 engagement engagement NN cord-013590-pkm81fq1 31 7 of of IN cord-013590-pkm81fq1 31 8 CD4 CD4 NNP cord-013590-pkm81fq1 31 9 or or CC cord-013590-pkm81fq1 31 10 CD8 CD8 NNP cord-013590-pkm81fq1 31 11 and and CC cord-013590-pkm81fq1 31 12 co co NN cord-013590-pkm81fq1 31 13 - - NN cord-013590-pkm81fq1 31 14 stimulation stimulation NN cord-013590-pkm81fq1 31 15 through through IN cord-013590-pkm81fq1 31 16 CD28 CD28 NNP cord-013590-pkm81fq1 31 17 , , , cord-013590-pkm81fq1 31 18 this this DT cord-013590-pkm81fq1 31 19 elicits elicit VBZ cord-013590-pkm81fq1 31 20 T t NN cord-013590-pkm81fq1 31 21 - - HYPH cord-013590-pkm81fq1 31 22 cell cell NN cord-013590-pkm81fq1 31 23 activation activation NN cord-013590-pkm81fq1 31 24 . . . cord-013590-pkm81fq1 32 1 In in IN cord-013590-pkm81fq1 32 2 contrast contrast NN cord-013590-pkm81fq1 32 3 , , , cord-013590-pkm81fq1 32 4 the the DT cord-013590-pkm81fq1 32 5 γδ γδ IN cord-013590-pkm81fq1 32 6 TCR TCR NNP cord-013590-pkm81fq1 32 7 does do VBZ cord-013590-pkm81fq1 32 8 not not RB cord-013590-pkm81fq1 32 9 require require VB cord-013590-pkm81fq1 32 10 MHC MHC NNP cord-013590-pkm81fq1 32 11 - - HYPH cord-013590-pkm81fq1 32 12 mediated mediate VBN cord-013590-pkm81fq1 32 13 antigen antigen NN cord-013590-pkm81fq1 32 14 presentation presentation NN cord-013590-pkm81fq1 32 15 and and CC cord-013590-pkm81fq1 32 16 no no DT cord-013590-pkm81fq1 32 17 general general JJ cord-013590-pkm81fq1 32 18 requirement requirement NN cord-013590-pkm81fq1 32 19 for for IN cord-013590-pkm81fq1 32 20 co co JJ cord-013590-pkm81fq1 32 21 - - JJ cord-013590-pkm81fq1 32 22 receptor receptor JJ cord-013590-pkm81fq1 32 23 interaction interaction NN cord-013590-pkm81fq1 32 24 has have VBZ cord-013590-pkm81fq1 32 25 been be VBN cord-013590-pkm81fq1 32 26 identified identify VBN cord-013590-pkm81fq1 32 27 so so RB cord-013590-pkm81fq1 32 28 far far RB cord-013590-pkm81fq1 32 29 . . . cord-013590-pkm81fq1 33 1 This this DT cord-013590-pkm81fq1 33 2 has have VBZ cord-013590-pkm81fq1 33 3 led lead VBN cord-013590-pkm81fq1 33 4 to to IN cord-013590-pkm81fq1 33 5 the the DT cord-013590-pkm81fq1 33 6 notion notion NN cord-013590-pkm81fq1 33 7 that that IN cord-013590-pkm81fq1 33 8 the the DT cord-013590-pkm81fq1 33 9 mere mere JJ cord-013590-pkm81fq1 33 10 binding binding NN cord-013590-pkm81fq1 33 11 of of IN cord-013590-pkm81fq1 33 12 the the DT cord-013590-pkm81fq1 33 13 γδ γδ NN cord-013590-pkm81fq1 33 14 TCR TCR NNP cord-013590-pkm81fq1 33 15 to to IN cord-013590-pkm81fq1 33 16 its -PRON- PRP$ cord-013590-pkm81fq1 33 17 cognate cognate JJ cord-013590-pkm81fq1 33 18 antigen antigen NN cord-013590-pkm81fq1 33 19 is be VBZ cord-013590-pkm81fq1 33 20 sufficient sufficient JJ cord-013590-pkm81fq1 33 21 for for IN cord-013590-pkm81fq1 33 22 activation activation NN cord-013590-pkm81fq1 33 23 . . . cord-013590-pkm81fq1 34 1 Moreover moreover RB cord-013590-pkm81fq1 34 2 , , , cord-013590-pkm81fq1 34 3 γδ γδ CC cord-013590-pkm81fq1 34 4 TCRs tcr NNS cord-013590-pkm81fq1 34 5 have have VBP cord-013590-pkm81fq1 34 6 the the DT cord-013590-pkm81fq1 34 7 ability ability NN cord-013590-pkm81fq1 34 8 for for IN cord-013590-pkm81fq1 34 9 both both DT cord-013590-pkm81fq1 34 10 innate innate JJ cord-013590-pkm81fq1 34 11 and and CC cord-013590-pkm81fq1 34 12 adaptive adaptive JJ cord-013590-pkm81fq1 34 13 ligand ligand NN cord-013590-pkm81fq1 34 14 recognition recognition NN cord-013590-pkm81fq1 34 15 via via IN cord-013590-pkm81fq1 34 16 either either DT cord-013590-pkm81fq1 34 17 germline germline NN cord-013590-pkm81fq1 34 18 - - HYPH cord-013590-pkm81fq1 34 19 encoded encode VBN cord-013590-pkm81fq1 34 20 regions region NNS cord-013590-pkm81fq1 34 21 of of IN cord-013590-pkm81fq1 34 22 the the DT cord-013590-pkm81fq1 34 23 receptor receptor NN cord-013590-pkm81fq1 34 24 , , , cord-013590-pkm81fq1 34 25 reminiscent reminiscent JJ cord-013590-pkm81fq1 34 26 of of IN cord-013590-pkm81fq1 34 27 PRRs prr NNS cord-013590-pkm81fq1 34 28 or or CC cord-013590-pkm81fq1 34 29 adaptive adaptive JJ cord-013590-pkm81fq1 34 30 antigen antigen NN cord-013590-pkm81fq1 34 31 binding bind VBG cord-013590-pkm81fq1 34 32 via via IN cord-013590-pkm81fq1 34 33 the the DT cord-013590-pkm81fq1 34 34 CDRs cdr NNS cord-013590-pkm81fq1 34 35 . . . cord-013590-pkm81fq1 35 1 17 17 CD cord-013590-pkm81fq1 36 1 Although although IN cord-013590-pkm81fq1 36 2 central central JJ cord-013590-pkm81fq1 36 3 for for IN cord-013590-pkm81fq1 36 4 understanding understanding NN cord-013590-pkm81fq1 36 5 γδ γδ IN cord-013590-pkm81fq1 36 6 T t NN cord-013590-pkm81fq1 36 7 - - HYPH cord-013590-pkm81fq1 36 8 cell cell NN cord-013590-pkm81fq1 36 9 biology biology NN cord-013590-pkm81fq1 36 10 and and CC cord-013590-pkm81fq1 36 11 their -PRON- PRP$ cord-013590-pkm81fq1 36 12 application application NN cord-013590-pkm81fq1 36 13 in in IN cord-013590-pkm81fq1 36 14 therapeutic therapeutic JJ cord-013590-pkm81fq1 36 15 approaches approach NNS cord-013590-pkm81fq1 36 16 , , , cord-013590-pkm81fq1 36 17 the the DT cord-013590-pkm81fq1 36 18 identification identification NN cord-013590-pkm81fq1 36 19 of of IN cord-013590-pkm81fq1 36 20 γδ γδ NN cord-013590-pkm81fq1 37 1 TCR TCR NNP cord-013590-pkm81fq1 37 2 antigens antigen NNS cord-013590-pkm81fq1 37 3 has have VBZ cord-013590-pkm81fq1 37 4 been be VBN cord-013590-pkm81fq1 37 5 proven prove VBN cord-013590-pkm81fq1 37 6 challenging challenging JJ cord-013590-pkm81fq1 37 7 for for IN cord-013590-pkm81fq1 37 8 several several JJ cord-013590-pkm81fq1 37 9 reasons reason NNS cord-013590-pkm81fq1 37 10 . . . cord-013590-pkm81fq1 38 1 First first RB cord-013590-pkm81fq1 38 2 , , , cord-013590-pkm81fq1 38 3 since since IN cord-013590-pkm81fq1 38 4 no no DT cord-013590-pkm81fq1 38 5 general general JJ cord-013590-pkm81fq1 38 6 restricting restrict VBG cord-013590-pkm81fq1 38 7 molecule molecule NN cord-013590-pkm81fq1 38 8 could could MD cord-013590-pkm81fq1 38 9 be be VB cord-013590-pkm81fq1 38 10 identified identify VBN cord-013590-pkm81fq1 38 11 for for IN cord-013590-pkm81fq1 38 12 the the DT cord-013590-pkm81fq1 38 13 γδ γδ NNP cord-013590-pkm81fq1 38 14 TCR TCR NNP cord-013590-pkm81fq1 38 15 , , , cord-013590-pkm81fq1 38 16 the the DT cord-013590-pkm81fq1 38 17 antigens antigen NNS cord-013590-pkm81fq1 38 18 could could MD cord-013590-pkm81fq1 38 19 be be VB cord-013590-pkm81fq1 38 20 virtually virtually RB cord-013590-pkm81fq1 38 21 any any DT cord-013590-pkm81fq1 38 22 molecule molecule NN cord-013590-pkm81fq1 38 23 present present JJ cord-013590-pkm81fq1 38 24 on on IN cord-013590-pkm81fq1 38 25 cell cell NN cord-013590-pkm81fq1 38 26 surfaces surface NNS cord-013590-pkm81fq1 38 27 or or CC cord-013590-pkm81fq1 38 28 in in IN cord-013590-pkm81fq1 38 29 the the DT cord-013590-pkm81fq1 38 30 surrounding surround VBG cord-013590-pkm81fq1 38 31 extracellular extracellular JJ cord-013590-pkm81fq1 38 32 space space NN cord-013590-pkm81fq1 38 33 . . . cord-013590-pkm81fq1 39 1 This this DT cord-013590-pkm81fq1 39 2 becomes become VBZ cord-013590-pkm81fq1 39 3 particularly particularly RB cord-013590-pkm81fq1 39 4 problematic problematic JJ cord-013590-pkm81fq1 39 5 if if IN cord-013590-pkm81fq1 39 6 not not RB cord-013590-pkm81fq1 39 7 only only RB cord-013590-pkm81fq1 39 8 proteins protein NNS cord-013590-pkm81fq1 39 9 , , , cord-013590-pkm81fq1 39 10 which which WDT cord-013590-pkm81fq1 39 11 are be VBP cord-013590-pkm81fq1 39 12 already already RB cord-013590-pkm81fq1 39 13 very very RB cord-013590-pkm81fq1 39 14 diverse diverse JJ cord-013590-pkm81fq1 39 15 , , , cord-013590-pkm81fq1 39 16 but but CC cord-013590-pkm81fq1 39 17 also also RB cord-013590-pkm81fq1 39 18 carbohydrates carbohydrate NNS cord-013590-pkm81fq1 39 19 , , , cord-013590-pkm81fq1 39 20 lipids lipid NNS cord-013590-pkm81fq1 39 21 and and CC cord-013590-pkm81fq1 39 22 nucleic nucleic JJ cord-013590-pkm81fq1 39 23 acids acid NNS cord-013590-pkm81fq1 39 24 could could MD cord-013590-pkm81fq1 39 25 be be VB cord-013590-pkm81fq1 39 26 recognized recognize VBN cord-013590-pkm81fq1 39 27 or or CC cord-013590-pkm81fq1 39 28 at at IN cord-013590-pkm81fq1 39 29 least least JJS cord-013590-pkm81fq1 39 30 involved involve VBN cord-013590-pkm81fq1 39 31 in in IN cord-013590-pkm81fq1 39 32 the the DT cord-013590-pkm81fq1 39 33 recognition recognition NN cord-013590-pkm81fq1 39 34 because because IN cord-013590-pkm81fq1 39 35 this this DT cord-013590-pkm81fq1 39 36 further further JJ cord-013590-pkm81fq1 39 37 increases increase VBZ cord-013590-pkm81fq1 39 38 the the DT cord-013590-pkm81fq1 39 39 complexity complexity NN cord-013590-pkm81fq1 39 40 of of IN cord-013590-pkm81fq1 39 41 the the DT cord-013590-pkm81fq1 39 42 question question NN cord-013590-pkm81fq1 39 43 and and CC cord-013590-pkm81fq1 39 44 is be VBZ cord-013590-pkm81fq1 39 45 technically technically RB cord-013590-pkm81fq1 39 46 demanding demand VBG cord-013590-pkm81fq1 39 47 to to TO cord-013590-pkm81fq1 39 48 address address VB cord-013590-pkm81fq1 39 49 . . . cord-013590-pkm81fq1 40 1 Second second RB cord-013590-pkm81fq1 40 2 , , , cord-013590-pkm81fq1 40 3 the the DT cord-013590-pkm81fq1 40 4 affinity affinity NN cord-013590-pkm81fq1 40 5 of of IN cord-013590-pkm81fq1 40 6 TCRs tcr NNS cord-013590-pkm81fq1 40 7 to to IN cord-013590-pkm81fq1 40 8 their -PRON- PRP$ cord-013590-pkm81fq1 40 9 antigens antigen NNS cord-013590-pkm81fq1 40 10 is be VBZ cord-013590-pkm81fq1 40 11 typically typically RB cord-013590-pkm81fq1 40 12 low low JJ cord-013590-pkm81fq1 40 13 being be VBG cord-013590-pkm81fq1 40 14 mostly mostly RB cord-013590-pkm81fq1 40 15 within within IN cord-013590-pkm81fq1 40 16 the the DT cord-013590-pkm81fq1 40 17 range range NN cord-013590-pkm81fq1 40 18 of of IN cord-013590-pkm81fq1 41 1 1 1 LS cord-013590-pkm81fq1 41 2 - - SYM cord-013590-pkm81fq1 41 3 100 100 CD cord-013590-pkm81fq1 41 4 µM. µm. NN cord-013590-pkm81fq1 41 5 Therefore therefore RB cord-013590-pkm81fq1 41 6 , , , cord-013590-pkm81fq1 41 7 classical classical JJ cord-013590-pkm81fq1 41 8 methods method NNS cord-013590-pkm81fq1 41 9 of of IN cord-013590-pkm81fq1 41 10 protein protein NN cord-013590-pkm81fq1 41 11 biochemistry biochemistry NN cord-013590-pkm81fq1 41 12 can can MD cord-013590-pkm81fq1 41 13 not not RB cord-013590-pkm81fq1 41 14 be be VB cord-013590-pkm81fq1 41 15 applied apply VBN cord-013590-pkm81fq1 41 16 . . . cord-013590-pkm81fq1 42 1 18 18 CD cord-013590-pkm81fq1 42 2 Alternative alternative JJ cord-013590-pkm81fq1 42 3 methods method NNS cord-013590-pkm81fq1 42 4 like like IN cord-013590-pkm81fq1 42 5 the the DT cord-013590-pkm81fq1 42 6 generation generation NN cord-013590-pkm81fq1 42 7 of of IN cord-013590-pkm81fq1 42 8 blocking block VBG cord-013590-pkm81fq1 42 9 antibodies antibody NNS cord-013590-pkm81fq1 42 10 , , , cord-013590-pkm81fq1 42 11 genetic genetic JJ cord-013590-pkm81fq1 42 12 approaches approach NNS cord-013590-pkm81fq1 42 13 or or CC cord-013590-pkm81fq1 42 14 tetramer tetramer NN cord-013590-pkm81fq1 42 15 staining stain VBG cord-013590-pkm81fq1 42 16 with with IN cord-013590-pkm81fq1 42 17 known know VBN cord-013590-pkm81fq1 42 18 Tcell Tcell NNP cord-013590-pkm81fq1 42 19 antigens antigen NNS cord-013590-pkm81fq1 42 20 is be VBZ cord-013590-pkm81fq1 42 21 on on IN cord-013590-pkm81fq1 42 22 the the DT cord-013590-pkm81fq1 42 23 one one CD cord-013590-pkm81fq1 42 24 hand hand NN cord-013590-pkm81fq1 42 25 side side NN cord-013590-pkm81fq1 42 26 tedious tedious JJ cord-013590-pkm81fq1 42 27 and and CC cord-013590-pkm81fq1 42 28 labor labor NN cord-013590-pkm81fq1 42 29 - - HYPH cord-013590-pkm81fq1 42 30 intensive intensive JJ cord-013590-pkm81fq1 42 31 or or CC cord-013590-pkm81fq1 42 32 on on IN cord-013590-pkm81fq1 42 33 the the DT cord-013590-pkm81fq1 42 34 other other JJ cord-013590-pkm81fq1 42 35 hand hand NN cord-013590-pkm81fq1 42 36 requires require VBZ cord-013590-pkm81fq1 42 37 a a DT cord-013590-pkm81fq1 42 38 priori priori FW cord-013590-pkm81fq1 42 39 knowledge knowledge NN cord-013590-pkm81fq1 42 40 of of IN cord-013590-pkm81fq1 42 41 possible possible JJ cord-013590-pkm81fq1 42 42 candidates candidate NNS cord-013590-pkm81fq1 42 43 , , , cord-013590-pkm81fq1 42 44 which which WDT cord-013590-pkm81fq1 42 45 introduces introduce VBZ cord-013590-pkm81fq1 42 46 a a DT cord-013590-pkm81fq1 42 47 bias bias NN cord-013590-pkm81fq1 42 48 . . . cord-013590-pkm81fq1 43 1 18 18 CD cord-013590-pkm81fq1 43 2 , , , cord-013590-pkm81fq1 43 3 19 19 CD cord-013590-pkm81fq1 43 4 Third Third NNP cord-013590-pkm81fq1 43 5 , , , cord-013590-pkm81fq1 43 6 it -PRON- PRP cord-013590-pkm81fq1 43 7 is be VBZ cord-013590-pkm81fq1 43 8 difficult difficult JJ cord-013590-pkm81fq1 43 9 to to TO cord-013590-pkm81fq1 43 10 assess assess VB cord-013590-pkm81fq1 43 11 whether whether IN cord-013590-pkm81fq1 43 12 the the DT cord-013590-pkm81fq1 43 13 recognition recognition NN cord-013590-pkm81fq1 43 14 of of IN cord-013590-pkm81fq1 43 15 certain certain JJ cord-013590-pkm81fq1 43 16 antigens antigen NNS cord-013590-pkm81fq1 43 17 by by IN cord-013590-pkm81fq1 43 18 γδ γδ IN cord-013590-pkm81fq1 43 19 TCRs tcr NNS cord-013590-pkm81fq1 43 20 can can MD cord-013590-pkm81fq1 43 21 be be VB cord-013590-pkm81fq1 43 22 generalized generalize VBN cord-013590-pkm81fq1 43 23 , , , cord-013590-pkm81fq1 43 24 because because IN cord-013590-pkm81fq1 43 25 a a DT cord-013590-pkm81fq1 43 26 number number NN cord-013590-pkm81fq1 43 27 of of IN cord-013590-pkm81fq1 43 28 known know VBN cord-013590-pkm81fq1 43 29 antigens antigen NNS cord-013590-pkm81fq1 43 30 are be VBP cord-013590-pkm81fq1 43 31 bound bind VBN cord-013590-pkm81fq1 43 32 solely solely RB cord-013590-pkm81fq1 43 33 by by IN cord-013590-pkm81fq1 43 34 particular particular JJ cord-013590-pkm81fq1 43 35 clones clone NNS cord-013590-pkm81fq1 43 36 that that WDT cord-013590-pkm81fq1 43 37 have have VBP cord-013590-pkm81fq1 43 38 been be VBN cord-013590-pkm81fq1 43 39 identified identify VBN cord-013590-pkm81fq1 43 40 in in IN cord-013590-pkm81fq1 43 41 individuals individual NNS cord-013590-pkm81fq1 43 42 . . . cord-013590-pkm81fq1 44 1 Moreover moreover RB cord-013590-pkm81fq1 44 2 , , , cord-013590-pkm81fq1 44 3 findings finding NNS cord-013590-pkm81fq1 44 4 in in IN cord-013590-pkm81fq1 44 5 the the DT cord-013590-pkm81fq1 44 6 mouse mouse NN cord-013590-pkm81fq1 44 7 system system NN cord-013590-pkm81fq1 44 8 can can MD cord-013590-pkm81fq1 44 9 in in IN cord-013590-pkm81fq1 44 10 most most JJS cord-013590-pkm81fq1 44 11 cases case NNS cord-013590-pkm81fq1 44 12 not not RB cord-013590-pkm81fq1 44 13 be be VB cord-013590-pkm81fq1 44 14 translated translate VBN cord-013590-pkm81fq1 44 15 into into IN cord-013590-pkm81fq1 44 16 the the DT cord-013590-pkm81fq1 44 17 human human JJ cord-013590-pkm81fq1 44 18 system system NN cord-013590-pkm81fq1 44 19 and and CC cord-013590-pkm81fq1 44 20 vice vice NN cord-013590-pkm81fq1 44 21 versa versa RB cord-013590-pkm81fq1 44 22 because because IN cord-013590-pkm81fq1 44 23 the the DT cord-013590-pkm81fq1 44 24 TCR TCR NNP cord-013590-pkm81fq1 44 25 sequences sequence NNS cord-013590-pkm81fq1 44 26 and and CC cord-013590-pkm81fq1 44 27 subsets subset NNS cord-013590-pkm81fq1 44 28 in in IN cord-013590-pkm81fq1 44 29 mice mouse NNS cord-013590-pkm81fq1 44 30 and and CC cord-013590-pkm81fq1 44 31 humans human NNS cord-013590-pkm81fq1 44 32 differ differ VBP cord-013590-pkm81fq1 44 33 substantially substantially RB cord-013590-pkm81fq1 44 34 . . . cord-013590-pkm81fq1 45 1 This this DT cord-013590-pkm81fq1 45 2 also also RB cord-013590-pkm81fq1 45 3 complicates complicate VBZ cord-013590-pkm81fq1 45 4 the the DT cord-013590-pkm81fq1 45 5 assessment assessment NN cord-013590-pkm81fq1 45 6 of of IN cord-013590-pkm81fq1 45 7 physiological physiological JJ cord-013590-pkm81fq1 45 8 relevance relevance NN cord-013590-pkm81fq1 45 9 of of IN cord-013590-pkm81fq1 45 10 many many JJ cord-013590-pkm81fq1 45 11 human human NN cord-013590-pkm81fq1 45 12 γδ γδ IN cord-013590-pkm81fq1 45 13 TCR TCR NNP cord-013590-pkm81fq1 45 14 ligands ligand NNS cord-013590-pkm81fq1 45 15 since since IN cord-013590-pkm81fq1 45 16 they -PRON- PRP cord-013590-pkm81fq1 45 17 can can MD cord-013590-pkm81fq1 45 18 be be VB cord-013590-pkm81fq1 45 19 identified identify VBN cord-013590-pkm81fq1 45 20 only only RB cord-013590-pkm81fq1 45 21 in in IN cord-013590-pkm81fq1 45 22 vitro vitro FW cord-013590-pkm81fq1 45 23 without without IN cord-013590-pkm81fq1 45 24 the the DT cord-013590-pkm81fq1 45 25 possibility possibility NN cord-013590-pkm81fq1 45 26 to to TO cord-013590-pkm81fq1 45 27 test test VB cord-013590-pkm81fq1 45 28 their -PRON- PRP$ cord-013590-pkm81fq1 45 29 functionality functionality NN cord-013590-pkm81fq1 45 30 in in IN cord-013590-pkm81fq1 45 31 transgenic transgenic JJ cord-013590-pkm81fq1 45 32 animals animal NNS cord-013590-pkm81fq1 45 33 . . . cord-013590-pkm81fq1 46 1 Despite despite IN cord-013590-pkm81fq1 46 2 all all PDT cord-013590-pkm81fq1 46 3 these these DT cord-013590-pkm81fq1 46 4 obstacles obstacle NNS cord-013590-pkm81fq1 46 5 , , , cord-013590-pkm81fq1 46 6 several several JJ cord-013590-pkm81fq1 46 7 antigens antigen NNS cord-013590-pkm81fq1 46 8 for for IN cord-013590-pkm81fq1 46 9 the the DT cord-013590-pkm81fq1 46 10 γδ γδ NN cord-013590-pkm81fq1 47 1 TCR TCR NNP cord-013590-pkm81fq1 47 2 have have VBP cord-013590-pkm81fq1 47 3 been be VBN cord-013590-pkm81fq1 47 4 identified identify VBN cord-013590-pkm81fq1 47 5 since since IN cord-013590-pkm81fq1 47 6 the the DT cord-013590-pkm81fq1 47 7 discovery discovery NN cord-013590-pkm81fq1 47 8 of of IN cord-013590-pkm81fq1 47 9 γδ γδ NNP cord-013590-pkm81fq1 47 10 T t NN cord-013590-pkm81fq1 47 11 cells cell NNS cord-013590-pkm81fq1 47 12 ( ( -LRB- cord-013590-pkm81fq1 47 13 see see VB cord-013590-pkm81fq1 47 14 Table table NN cord-013590-pkm81fq1 47 15 1 1 CD cord-013590-pkm81fq1 47 16 ) ) -RRB- cord-013590-pkm81fq1 47 17 . . . cord-013590-pkm81fq1 48 1 Due due IN cord-013590-pkm81fq1 48 2 to to IN cord-013590-pkm81fq1 48 3 recent recent JJ cord-013590-pkm81fq1 48 4 progress progress NN cord-013590-pkm81fq1 48 5 made make VBN cord-013590-pkm81fq1 48 6 in in IN cord-013590-pkm81fq1 48 7 this this DT cord-013590-pkm81fq1 48 8 field field NN cord-013590-pkm81fq1 48 9 , , , cord-013590-pkm81fq1 48 10 we -PRON- PRP cord-013590-pkm81fq1 48 11 aim aim VBP cord-013590-pkm81fq1 48 12 to to TO cord-013590-pkm81fq1 48 13 summarize summarize VB cord-013590-pkm81fq1 48 14 in in IN cord-013590-pkm81fq1 48 15 this this DT cord-013590-pkm81fq1 48 16 review review NN cord-013590-pkm81fq1 48 17 the the DT cord-013590-pkm81fq1 48 18 current current JJ cord-013590-pkm81fq1 48 19 knowledge knowledge NN cord-013590-pkm81fq1 48 20 about about IN cord-013590-pkm81fq1 48 21 adaptive adaptive JJ cord-013590-pkm81fq1 48 22 recognition recognition NN cord-013590-pkm81fq1 48 23 of of IN cord-013590-pkm81fq1 48 24 MHClike mhclike JJ cord-013590-pkm81fq1 48 25 molecules molecule NNS cord-013590-pkm81fq1 48 26 , , , cord-013590-pkm81fq1 48 27 the the DT cord-013590-pkm81fq1 48 28 concept concept NN cord-013590-pkm81fq1 48 29 of of IN cord-013590-pkm81fq1 48 30 immunoglobulin immunoglobulin NN cord-013590-pkm81fq1 48 31 - - HYPH cord-013590-pkm81fq1 48 32 like like JJ cord-013590-pkm81fq1 48 33 antigen antigen NN cord-013590-pkm81fq1 48 34 recognition recognition NN cord-013590-pkm81fq1 48 35 as as RB cord-013590-pkm81fq1 48 36 well well RB cord-013590-pkm81fq1 48 37 as as IN cord-013590-pkm81fq1 48 38 innate innate JJ cord-013590-pkm81fq1 48 39 recognition recognition NN cord-013590-pkm81fq1 48 40 of of IN cord-013590-pkm81fq1 48 41 phosphoantigens phosphoantigen NNS cord-013590-pkm81fq1 48 42 and and CC cord-013590-pkm81fq1 48 43 butyrophilins butyrophilin NNS cord-013590-pkm81fq1 48 44 by by IN cord-013590-pkm81fq1 48 45 the the DT cord-013590-pkm81fq1 48 46 γδ γδ NNP cord-013590-pkm81fq1 48 47 TCR TCR NNP cord-013590-pkm81fq1 48 48 . . . cord-013590-pkm81fq1 49 1 Moreover moreover RB cord-013590-pkm81fq1 49 2 , , , cord-013590-pkm81fq1 49 3 we -PRON- PRP cord-013590-pkm81fq1 49 4 speculate speculate VBP cord-013590-pkm81fq1 49 5 on on IN cord-013590-pkm81fq1 49 6 how how WRB cord-013590-pkm81fq1 49 7 the the DT cord-013590-pkm81fq1 49 8 γδ γδ NN cord-013590-pkm81fq1 49 9 TCR TCR NNP cord-013590-pkm81fq1 49 10 might may MD cord-013590-pkm81fq1 49 11 be be VB cord-013590-pkm81fq1 49 12 able able JJ cord-013590-pkm81fq1 49 13 to to TO cord-013590-pkm81fq1 49 14 discriminate discriminate VB cord-013590-pkm81fq1 49 15 between between IN cord-013590-pkm81fq1 49 16 physiological physiological JJ cord-013590-pkm81fq1 49 17 and and CC cord-013590-pkm81fq1 49 18 pathological pathological JJ cord-013590-pkm81fq1 49 19 conditions condition NNS cord-013590-pkm81fq1 49 20 . . . cord-013590-pkm81fq1 50 1 The the DT cord-013590-pkm81fq1 50 2 paradigm paradigm NN cord-013590-pkm81fq1 50 3 of of IN cord-013590-pkm81fq1 50 4 γδ γδ NN cord-013590-pkm81fq1 50 5 T t NN cord-013590-pkm81fq1 50 6 cells cell NNS cord-013590-pkm81fq1 50 7 not not RB cord-013590-pkm81fq1 50 8 being be VBG cord-013590-pkm81fq1 50 9 restricted restrict VBN cord-013590-pkm81fq1 50 10 to to IN cord-013590-pkm81fq1 50 11 MHC MHC NNP cord-013590-pkm81fq1 50 12 is be VBZ cord-013590-pkm81fq1 50 13 based base VBN cord-013590-pkm81fq1 50 14 to to IN cord-013590-pkm81fq1 50 15 a a DT cord-013590-pkm81fq1 50 16 large large JJ cord-013590-pkm81fq1 50 17 extent extent NN cord-013590-pkm81fq1 50 18 on on IN cord-013590-pkm81fq1 50 19 the the DT cord-013590-pkm81fq1 50 20 observation observation NN cord-013590-pkm81fq1 50 21 that that WDT cord-013590-pkm81fq1 50 22 γδ γδ NNP cord-013590-pkm81fq1 50 23 T t NN cord-013590-pkm81fq1 50 24 cells cell NNS cord-013590-pkm81fq1 50 25 develop develop VBP cord-013590-pkm81fq1 50 26 normally normally RB cord-013590-pkm81fq1 50 27 in in IN cord-013590-pkm81fq1 50 28 β2-microglobulin β2-microglobulin NNP cord-013590-pkm81fq1 50 29 knockout knockout NN cord-013590-pkm81fq1 50 30 mice mouse NNS cord-013590-pkm81fq1 50 31 whereas whereas IN cord-013590-pkm81fq1 50 32 αβ αβ FW cord-013590-pkm81fq1 50 33 T t NN cord-013590-pkm81fq1 50 34 cells cell NNS cord-013590-pkm81fq1 50 35 are be VBP cord-013590-pkm81fq1 50 36 missing miss VBG cord-013590-pkm81fq1 50 37 due due IN cord-013590-pkm81fq1 50 38 to to IN cord-013590-pkm81fq1 50 39 missing miss VBG cord-013590-pkm81fq1 50 40 positive positive JJ cord-013590-pkm81fq1 50 41 selection selection NN cord-013590-pkm81fq1 50 42 in in IN cord-013590-pkm81fq1 50 43 the the DT cord-013590-pkm81fq1 50 44 thymus thymus NN cord-013590-pkm81fq1 50 45 . . . cord-013590-pkm81fq1 51 1 20 20 CD cord-013590-pkm81fq1 51 2 26 26 CD cord-013590-pkm81fq1 52 1 In in IN cord-013590-pkm81fq1 52 2 contrast contrast NN cord-013590-pkm81fq1 52 3 , , , cord-013590-pkm81fq1 52 4 experiments experiment NNS cord-013590-pkm81fq1 52 5 with with IN cord-013590-pkm81fq1 52 6 mice mouse NNS cord-013590-pkm81fq1 52 7 expressing express VBG cord-013590-pkm81fq1 52 8 another another DT cord-013590-pkm81fq1 52 9 T10/ T10/ . cord-013590-pkm81fq1 53 1 T22-reactive T22-reactive NNP cord-013590-pkm81fq1 54 1 γδ γδ RB cord-013590-pkm81fq1 55 1 TCR TCR NNP cord-013590-pkm81fq1 55 2 ( ( -LRB- cord-013590-pkm81fq1 55 3 KN6 KN6 NNP cord-013590-pkm81fq1 55 4 ) ) -RRB- cord-013590-pkm81fq1 55 5 27 27 CD cord-013590-pkm81fq1 55 6 and and CC cord-013590-pkm81fq1 55 7 an an DT cord-013590-pkm81fq1 55 8 MHC MHC NNP cord-013590-pkm81fq1 55 9 class class NN cord-013590-pkm81fq1 56 1 I -PRON- PRP cord-013590-pkm81fq1 56 2 - - HYPH cord-013590-pkm81fq1 56 3 reactive reactive JJ cord-013590-pkm81fq1 56 4 γδ γδ XX cord-013590-pkm81fq1 57 1 TCR TCR NNP cord-013590-pkm81fq1 57 2 28 28 CD cord-013590-pkm81fq1 57 3 showed show VBD cord-013590-pkm81fq1 57 4 that that IN cord-013590-pkm81fq1 57 5 the the DT cord-013590-pkm81fq1 57 6 development development NN cord-013590-pkm81fq1 57 7 and and CC cord-013590-pkm81fq1 57 8 maturation maturation NN cord-013590-pkm81fq1 57 9 of of IN cord-013590-pkm81fq1 57 10 γδ γδ NN cord-013590-pkm81fq1 57 11 T t NN cord-013590-pkm81fq1 57 12 cells cell NNS cord-013590-pkm81fq1 57 13 were be VBD cord-013590-pkm81fq1 57 14 impaired impair VBN cord-013590-pkm81fq1 57 15 in in IN cord-013590-pkm81fq1 57 16 a a DT cord-013590-pkm81fq1 57 17 β2-microglobulin β2-microglobulin XX cord-013590-pkm81fq1 57 18 knockout knockout NN cord-013590-pkm81fq1 57 19 background background NN cord-013590-pkm81fq1 57 20 . . . cord-013590-pkm81fq1 58 1 As as IN cord-013590-pkm81fq1 58 2 the the DT cord-013590-pkm81fq1 58 3 β2-microglobulin β2-microglobulin NNP cord-013590-pkm81fq1 58 4 knockout knockout NN cord-013590-pkm81fq1 58 5 does do VBZ cord-013590-pkm81fq1 58 6 not not RB cord-013590-pkm81fq1 58 7 completely completely RB cord-013590-pkm81fq1 58 8 eliminate eliminate VB cord-013590-pkm81fq1 58 9 surface surface NN cord-013590-pkm81fq1 58 10 expression expression NN cord-013590-pkm81fq1 58 11 of of IN cord-013590-pkm81fq1 58 12 T10 T10 NNP cord-013590-pkm81fq1 58 13 / / SYM cord-013590-pkm81fq1 58 14 T22 T22 NNP cord-013590-pkm81fq1 58 15 , , , cord-013590-pkm81fq1 58 16 a a DT cord-013590-pkm81fq1 58 17 mouse mouse NN cord-013590-pkm81fq1 58 18 model model NN cord-013590-pkm81fq1 58 19 with with IN cord-013590-pkm81fq1 58 20 a a DT cord-013590-pkm81fq1 58 21 more more RBR cord-013590-pkm81fq1 58 22 specific specific JJ cord-013590-pkm81fq1 58 23 knockout knockout NN cord-013590-pkm81fq1 58 24 of of IN cord-013590-pkm81fq1 58 25 T10 T10 NNP cord-013590-pkm81fq1 58 26 and and CC cord-013590-pkm81fq1 58 27 T22 T22 NNP cord-013590-pkm81fq1 58 28 was be VBD cord-013590-pkm81fq1 58 29 generated generate VBN cord-013590-pkm81fq1 58 30 and and CC cord-013590-pkm81fq1 58 31 led lead VBN cord-013590-pkm81fq1 58 32 to to IN cord-013590-pkm81fq1 58 33 the the DT cord-013590-pkm81fq1 58 34 conclusion conclusion NN cord-013590-pkm81fq1 58 35 that that IN cord-013590-pkm81fq1 58 36 the the DT cord-013590-pkm81fq1 58 37 antigen antigen NN cord-013590-pkm81fq1 58 38 is be VBZ cord-013590-pkm81fq1 58 39 important important JJ cord-013590-pkm81fq1 58 40 for for IN cord-013590-pkm81fq1 58 41 the the DT cord-013590-pkm81fq1 58 42 development development NN cord-013590-pkm81fq1 58 43 of of IN cord-013590-pkm81fq1 58 44 γδ γδ NNP cord-013590-pkm81fq1 58 45 T T NNP cord-013590-pkm81fq1 58 46 cells cell NNS cord-013590-pkm81fq1 58 47 . . . cord-013590-pkm81fq1 59 1 29 29 CD cord-013590-pkm81fq1 60 1 However however RB cord-013590-pkm81fq1 60 2 , , , cord-013590-pkm81fq1 60 3 even even RB cord-013590-pkm81fq1 60 4 the the DT cord-013590-pkm81fq1 60 5 complete complete JJ cord-013590-pkm81fq1 60 6 absence absence NN cord-013590-pkm81fq1 60 7 of of IN cord-013590-pkm81fq1 60 8 the the DT cord-013590-pkm81fq1 60 9 respective respective JJ cord-013590-pkm81fq1 60 10 antigen antigen NN cord-013590-pkm81fq1 60 11 failed fail VBD cord-013590-pkm81fq1 60 12 to to TO cord-013590-pkm81fq1 60 13 abolish abolish VB cord-013590-pkm81fq1 60 14 the the DT cord-013590-pkm81fq1 60 15 generation generation NN cord-013590-pkm81fq1 60 16 of of IN cord-013590-pkm81fq1 60 17 at at IN cord-013590-pkm81fq1 60 18 least least JJS cord-013590-pkm81fq1 60 19 some some DT cord-013590-pkm81fq1 60 20 T22-reactive T22-reactive NNP cord-013590-pkm81fq1 60 21 γδ γδ CC cord-013590-pkm81fq1 60 22 T t NN cord-013590-pkm81fq1 60 23 cells cell NNS cord-013590-pkm81fq1 60 24 , , , cord-013590-pkm81fq1 60 25 which which WDT cord-013590-pkm81fq1 60 26 might may MD cord-013590-pkm81fq1 60 27 be be VB cord-013590-pkm81fq1 60 28 explained explain VBN cord-013590-pkm81fq1 60 29 by by IN cord-013590-pkm81fq1 60 30 a a DT cord-013590-pkm81fq1 60 31 certain certain JJ cord-013590-pkm81fq1 60 32 plasticity plasticity NN cord-013590-pkm81fq1 60 33 of of IN cord-013590-pkm81fq1 60 34 the the DT cord-013590-pkm81fq1 60 35 γδ γδ NN cord-013590-pkm81fq1 60 36 TCR TCR NNP cord-013590-pkm81fq1 60 37 for for IN cord-013590-pkm81fq1 60 38 different different JJ cord-013590-pkm81fq1 60 39 ligands ligand NNS cord-013590-pkm81fq1 60 40 . . . cord-013590-pkm81fq1 61 1 Thus thus RB cord-013590-pkm81fq1 61 2 , , , cord-013590-pkm81fq1 61 3 γδ γδ IN cord-013590-pkm81fq1 61 4 T t NN cord-013590-pkm81fq1 61 5 cells cell NNS cord-013590-pkm81fq1 61 6 can can MD cord-013590-pkm81fq1 61 7 develop develop VB cord-013590-pkm81fq1 61 8 without without IN cord-013590-pkm81fq1 61 9 the the DT cord-013590-pkm81fq1 61 10 presence presence NN cord-013590-pkm81fq1 61 11 of of IN cord-013590-pkm81fq1 61 12 their -PRON- PRP$ cord-013590-pkm81fq1 61 13 cognate cognate JJ cord-013590-pkm81fq1 61 14 antigen antigen NN cord-013590-pkm81fq1 61 15 but but CC cord-013590-pkm81fq1 61 16 their -PRON- PRP$ cord-013590-pkm81fq1 61 17 functional functional JJ cord-013590-pkm81fq1 61 18 maturation maturation NN cord-013590-pkm81fq1 61 19 is be VBZ cord-013590-pkm81fq1 61 20 heavily heavily RB cord-013590-pkm81fq1 61 21 impaired impaired JJ cord-013590-pkm81fq1 61 22 . . . cord-013590-pkm81fq1 62 1 Moreover moreover RB cord-013590-pkm81fq1 62 2 , , , cord-013590-pkm81fq1 62 3 nonexpanded nonexpanded JJ cord-013590-pkm81fq1 62 4 clones clone NNS cord-013590-pkm81fq1 62 5 reactive reactive JJ cord-013590-pkm81fq1 62 6 to to IN cord-013590-pkm81fq1 62 7 MHC MHC NNP cord-013590-pkm81fq1 62 8 or or CC cord-013590-pkm81fq1 62 9 MHC MHC NNP cord-013590-pkm81fq1 62 10 - - HYPH cord-013590-pkm81fq1 62 11 like like JJ cord-013590-pkm81fq1 62 12 molecules molecule NNS cord-013590-pkm81fq1 62 13 likely likely RB cord-013590-pkm81fq1 62 14 make make VBP cord-013590-pkm81fq1 62 15 up up RP cord-013590-pkm81fq1 62 16 only only RB cord-013590-pkm81fq1 62 17 a a DT cord-013590-pkm81fq1 62 18 small small JJ cord-013590-pkm81fq1 62 19 part part NN cord-013590-pkm81fq1 62 20 of of IN cord-013590-pkm81fq1 62 21 the the DT cord-013590-pkm81fq1 62 22 total total NN cord-013590-pkm81fq1 62 23 γδ γδ NN cord-013590-pkm81fq1 62 24 TCR TCR NNP cord-013590-pkm81fq1 62 25 repertoire repertoire NN cord-013590-pkm81fq1 62 26 and and CC cord-013590-pkm81fq1 62 27 their -PRON- PRP$ cord-013590-pkm81fq1 62 28 disappearance disappearance NN cord-013590-pkm81fq1 62 29 might may MD cord-013590-pkm81fq1 62 30 not not RB cord-013590-pkm81fq1 62 31 be be VB cord-013590-pkm81fq1 62 32 detectable detectable JJ cord-013590-pkm81fq1 62 33 in in IN cord-013590-pkm81fq1 62 34 β2-microglobulin β2-microglobulin NN cord-013590-pkm81fq1 62 35 knockout knockout NN cord-013590-pkm81fq1 62 36 mice mouse NNS cord-013590-pkm81fq1 62 37 . . . cord-013590-pkm81fq1 63 1 Therefore therefore RB cord-013590-pkm81fq1 63 2 , , , cord-013590-pkm81fq1 63 3 clones clone NNS cord-013590-pkm81fq1 63 4 reactive reactive JJ cord-013590-pkm81fq1 63 5 to to IN cord-013590-pkm81fq1 63 6 MHC MHC NNP cord-013590-pkm81fq1 63 7 or or CC cord-013590-pkm81fq1 63 8 MHC MHC NNP cord-013590-pkm81fq1 63 9 - - HYPH cord-013590-pkm81fq1 63 10 like like JJ cord-013590-pkm81fq1 63 11 molecules molecule NNS cord-013590-pkm81fq1 63 12 likely likely RB cord-013590-pkm81fq1 63 13 coexist coexist VBP cord-013590-pkm81fq1 63 14 next next RB cord-013590-pkm81fq1 63 15 to to IN cord-013590-pkm81fq1 63 16 those those DT cord-013590-pkm81fq1 63 17 recognizing recognize VBG cord-013590-pkm81fq1 63 18 non non JJ cord-013590-pkm81fq1 63 19 - - JJ cord-013590-pkm81fq1 63 20 MHC mhc JJ cord-013590-pkm81fq1 63 21 molecules molecule NNS cord-013590-pkm81fq1 63 22 . . . cord-013590-pkm81fq1 64 1 Examples example NNS cord-013590-pkm81fq1 64 2 of of IN cord-013590-pkm81fq1 64 3 γδ γδ NNP cord-013590-pkm81fq1 64 4 TCR TCR NNP cord-013590-pkm81fq1 64 5 - - HYPH cord-013590-pkm81fq1 64 6 ligands ligand NNS cord-013590-pkm81fq1 64 7 that that WDT cord-013590-pkm81fq1 64 8 are be VBP cord-013590-pkm81fq1 64 9 classical classical JJ cord-013590-pkm81fq1 64 10 MHC MHC NNP cord-013590-pkm81fq1 64 11 molecules molecule NNS cord-013590-pkm81fq1 64 12 comprise comprise VBP cord-013590-pkm81fq1 64 13 murine murine JJ cord-013590-pkm81fq1 64 14 MHC MHC NNP cord-013590-pkm81fq1 64 15 class class NN cord-013590-pkm81fq1 64 16 II II NNP cord-013590-pkm81fq1 64 17 molecule molecule NN cord-013590-pkm81fq1 64 18 I I NNP cord-013590-pkm81fq1 64 19 - - HYPH cord-013590-pkm81fq1 64 20 E E NNP cord-013590-pkm81fq1 64 21 22 22 CD cord-013590-pkm81fq1 64 22 and and CC cord-013590-pkm81fq1 64 23 class class NN cord-013590-pkm81fq1 65 1 I -PRON- PRP cord-013590-pkm81fq1 65 2 molecule molecule VBP cord-013590-pkm81fq1 65 3 H-2 h-2 NN cord-013590-pkm81fq1 65 4 , , , cord-013590-pkm81fq1 65 5 30 30 CD cord-013590-pkm81fq1 65 6 both both DT cord-013590-pkm81fq1 65 7 found find VBN cord-013590-pkm81fq1 65 8 to to TO cord-013590-pkm81fq1 65 9 activate activate VB cord-013590-pkm81fq1 65 10 cytotoxic cytotoxic JJ cord-013590-pkm81fq1 65 11 γδ γδ IN cord-013590-pkm81fq1 65 12 T t NN cord-013590-pkm81fq1 65 13 - - HYPH cord-013590-pkm81fq1 65 14 cell cell NN cord-013590-pkm81fq1 65 15 clones clone NNS cord-013590-pkm81fq1 65 16 derived derive VBN cord-013590-pkm81fq1 65 17 from from IN cord-013590-pkm81fq1 65 18 athymic athymic JJ cord-013590-pkm81fq1 65 19 mice mouse NNS cord-013590-pkm81fq1 65 20 . . . cord-013590-pkm81fq1 66 1 In in IN cord-013590-pkm81fq1 66 2 humans human NNS cord-013590-pkm81fq1 66 3 , , , cord-013590-pkm81fq1 66 4 HLA-24 HLA-24 NNP cord-013590-pkm81fq1 66 5 , , , cord-013590-pkm81fq1 66 6 31 31 CD cord-013590-pkm81fq1 66 7 HLA HLA NNP cord-013590-pkm81fq1 66 8 - - HYPH cord-013590-pkm81fq1 66 9 B27 B27 NNP cord-013590-pkm81fq1 66 10 , , , cord-013590-pkm81fq1 66 11 32 32 CD cord-013590-pkm81fq1 66 12 and and CC cord-013590-pkm81fq1 66 13 HLA HLA NNP cord-013590-pkm81fq1 66 14 - - HYPH cord-013590-pkm81fq1 66 15 A2 A2 NNP cord-013590-pkm81fq1 66 16 33 33 CD cord-013590-pkm81fq1 66 17 were be VBD cord-013590-pkm81fq1 66 18 specifically specifically RB cord-013590-pkm81fq1 66 19 activating activate VBG cord-013590-pkm81fq1 66 20 γδ γδ IN cord-013590-pkm81fq1 66 21 T t NN cord-013590-pkm81fq1 66 22 - - HYPH cord-013590-pkm81fq1 66 23 cell cell NN cord-013590-pkm81fq1 66 24 clones clone NNS cord-013590-pkm81fq1 66 25 derived derive VBN cord-013590-pkm81fq1 66 26 from from IN cord-013590-pkm81fq1 66 27 healthy healthy JJ cord-013590-pkm81fq1 66 28 individuals individual NNS cord-013590-pkm81fq1 66 29 that that WDT cord-013590-pkm81fq1 66 30 have have VBP cord-013590-pkm81fq1 66 31 been be VBN cord-013590-pkm81fq1 66 32 expanded expand VBN cord-013590-pkm81fq1 66 33 in in IN cord-013590-pkm81fq1 66 34 culture culture NN cord-013590-pkm81fq1 66 35 . . . cord-013590-pkm81fq1 67 1 All all PDT cord-013590-pkm81fq1 67 2 these these DT cord-013590-pkm81fq1 67 3 identified identify VBN cord-013590-pkm81fq1 67 4 interactions interaction NNS cord-013590-pkm81fq1 67 5 have have VBP cord-013590-pkm81fq1 67 6 in in IN cord-013590-pkm81fq1 67 7 common common JJ cord-013590-pkm81fq1 67 8 that that IN cord-013590-pkm81fq1 67 9 they -PRON- PRP cord-013590-pkm81fq1 67 10 are be VBP cord-013590-pkm81fq1 67 11 independent independent JJ cord-013590-pkm81fq1 67 12 of of IN cord-013590-pkm81fq1 67 13 peptide peptide JJ cord-013590-pkm81fq1 67 14 presentation presentation NN cord-013590-pkm81fq1 67 15 by by IN cord-013590-pkm81fq1 67 16 the the DT cord-013590-pkm81fq1 67 17 MHC MHC NNP cord-013590-pkm81fq1 67 18 , , , cord-013590-pkm81fq1 67 19 as as IN cord-013590-pkm81fq1 67 20 their -PRON- PRP$ cord-013590-pkm81fq1 67 21 activation activation NN cord-013590-pkm81fq1 67 22 also also RB cord-013590-pkm81fq1 67 23 occurred occur VBD cord-013590-pkm81fq1 67 24 in in IN cord-013590-pkm81fq1 67 25 cell cell NN cord-013590-pkm81fq1 67 26 lines line NNS cord-013590-pkm81fq1 67 27 with with IN cord-013590-pkm81fq1 67 28 peptide peptide NN cord-013590-pkm81fq1 67 29 - - HYPH cord-013590-pkm81fq1 67 30 loading loading NN cord-013590-pkm81fq1 67 31 defects defect NNS cord-013590-pkm81fq1 67 32 . . . cord-013590-pkm81fq1 68 1 These these DT cord-013590-pkm81fq1 68 2 γδ γδ IN cord-013590-pkm81fq1 68 3 T t NN cord-013590-pkm81fq1 68 4 - - HYPH cord-013590-pkm81fq1 68 5 cell cell NN cord-013590-pkm81fq1 68 6 clones clone NNS cord-013590-pkm81fq1 68 7 were be VBD cord-013590-pkm81fq1 68 8 therefore therefore RB cord-013590-pkm81fq1 68 9 qualified qualified JJ cord-013590-pkm81fq1 68 10 as as IN cord-013590-pkm81fq1 68 11 alloreactive alloreactive NNP cord-013590-pkm81fq1 68 12 . . . cord-013590-pkm81fq1 69 1 The the DT cord-013590-pkm81fq1 69 2 fact fact NN cord-013590-pkm81fq1 69 3 that that IN cord-013590-pkm81fq1 69 4 some some DT cord-013590-pkm81fq1 69 5 of of IN cord-013590-pkm81fq1 69 6 them -PRON- PRP cord-013590-pkm81fq1 69 7 are be VBP cord-013590-pkm81fq1 69 8 able able JJ cord-013590-pkm81fq1 69 9 to to TO cord-013590-pkm81fq1 69 10 cross cross VB cord-013590-pkm81fq1 69 11 - - VB cord-013590-pkm81fq1 69 12 react react VB cord-013590-pkm81fq1 69 13 with with IN cord-013590-pkm81fq1 69 14 some some DT cord-013590-pkm81fq1 69 15 subtype subtype NN cord-013590-pkm81fq1 69 16 of of IN cord-013590-pkm81fq1 69 17 the the DT cord-013590-pkm81fq1 69 18 same same JJ cord-013590-pkm81fq1 69 19 MHC MHC NNP cord-013590-pkm81fq1 69 20 indicates indicate VBZ cord-013590-pkm81fq1 69 21 that that IN cord-013590-pkm81fq1 69 22 they -PRON- PRP cord-013590-pkm81fq1 69 23 might may MD cord-013590-pkm81fq1 69 24 even even RB cord-013590-pkm81fq1 69 25 be be VB cord-013590-pkm81fq1 69 26 binding bind VBG cord-013590-pkm81fq1 69 27 to to IN cord-013590-pkm81fq1 69 28 less less RBR cord-013590-pkm81fq1 69 29 polymorphic polymorphic JJ cord-013590-pkm81fq1 69 30 parts part NNS cord-013590-pkm81fq1 69 31 of of IN cord-013590-pkm81fq1 69 32 the the DT cord-013590-pkm81fq1 69 33 MHC MHC NNP cord-013590-pkm81fq1 69 34 molecule molecule NN cord-013590-pkm81fq1 69 35 . . . cord-013590-pkm81fq1 70 1 Additionally additionally RB cord-013590-pkm81fq1 70 2 , , , cord-013590-pkm81fq1 70 3 a a DT cord-013590-pkm81fq1 70 4 further further JJ cord-013590-pkm81fq1 70 5 alloreactive alloreactive JJ cord-013590-pkm81fq1 70 6 Vγ5Vδ1 vγ5vδ1 NN cord-013590-pkm81fq1 71 1 + + CC cord-013590-pkm81fq1 71 2 TCR TCR NNP cord-013590-pkm81fq1 71 3 has have VBZ cord-013590-pkm81fq1 71 4 recently recently RB cord-013590-pkm81fq1 71 5 been be VBN cord-013590-pkm81fq1 71 6 found find VBN cord-013590-pkm81fq1 71 7 to to TO cord-013590-pkm81fq1 71 8 recognize recognize VB cord-013590-pkm81fq1 71 9 HLA HLA NNP cord-013590-pkm81fq1 71 10 - - HYPH cord-013590-pkm81fq1 71 11 A A NNP cord-013590-pkm81fq1 71 12 * * NFP cord-013590-pkm81fq1 71 13 24:02 24:02 CD cord-013590-pkm81fq1 71 14 on on IN cord-013590-pkm81fq1 71 15 cancer cancer NN cord-013590-pkm81fq1 71 16 cells cell NNS cord-013590-pkm81fq1 71 17 . . . cord-013590-pkm81fq1 72 1 23 23 CD cord-013590-pkm81fq1 73 1 It -PRON- PRP cord-013590-pkm81fq1 73 2 was be VBD cord-013590-pkm81fq1 73 3 shown show VBN cord-013590-pkm81fq1 73 4 to to TO cord-013590-pkm81fq1 73 5 be be VB cord-013590-pkm81fq1 73 6 dependent dependent JJ cord-013590-pkm81fq1 73 7 on on IN cord-013590-pkm81fq1 73 8 peptide peptide NN cord-013590-pkm81fq1 73 9 loading loading NN cord-013590-pkm81fq1 73 10 of of IN cord-013590-pkm81fq1 73 11 the the DT cord-013590-pkm81fq1 73 12 HLA HLA NNP cord-013590-pkm81fq1 73 13 complex complex NN cord-013590-pkm81fq1 73 14 but but CC cord-013590-pkm81fq1 73 15 not not RB cord-013590-pkm81fq1 73 16 the the DT cord-013590-pkm81fq1 73 17 presentation presentation NN cord-013590-pkm81fq1 73 18 of of IN cord-013590-pkm81fq1 73 19 a a DT cord-013590-pkm81fq1 73 20 specific specific JJ cord-013590-pkm81fq1 73 21 peptide peptide NN cord-013590-pkm81fq1 73 22 . . . cord-013590-pkm81fq1 74 1 Given give VBN cord-013590-pkm81fq1 74 2 the the DT cord-013590-pkm81fq1 74 3 increased increase VBN cord-013590-pkm81fq1 74 4 stability stability NN cord-013590-pkm81fq1 74 5 of of IN cord-013590-pkm81fq1 74 6 peptidepresenting peptidepresente VBG cord-013590-pkm81fq1 74 7 MHC MHC NNP cord-013590-pkm81fq1 74 8 molecules molecule NNS cord-013590-pkm81fq1 74 9 on on IN cord-013590-pkm81fq1 74 10 cell cell NN cord-013590-pkm81fq1 74 11 surfaces surface NNS cord-013590-pkm81fq1 74 12 , , , cord-013590-pkm81fq1 74 13 the the DT cord-013590-pkm81fq1 74 14 authors author NNS cord-013590-pkm81fq1 74 15 reasoned reason VBD cord-013590-pkm81fq1 74 16 that that IN cord-013590-pkm81fq1 74 17 the the DT cord-013590-pkm81fq1 74 18 random random JJ cord-013590-pkm81fq1 74 19 peptide peptide NN cord-013590-pkm81fq1 74 20 presentation presentation NN cord-013590-pkm81fq1 74 21 might may MD cord-013590-pkm81fq1 74 22 be be VB cord-013590-pkm81fq1 74 23 rather rather RB cord-013590-pkm81fq1 74 24 required require VBN cord-013590-pkm81fq1 74 25 for for IN cord-013590-pkm81fq1 74 26 target target NN cord-013590-pkm81fq1 74 27 stabilization stabilization NN cord-013590-pkm81fq1 74 28 than than IN cord-013590-pkm81fq1 74 29 for for IN cord-013590-pkm81fq1 74 30 specific specific JJ cord-013590-pkm81fq1 74 31 antigen antigen NN cord-013590-pkm81fq1 74 32 presentation presentation NN cord-013590-pkm81fq1 74 33 . . . cord-013590-pkm81fq1 75 1 In in IN cord-013590-pkm81fq1 75 2 contrast contrast NN cord-013590-pkm81fq1 75 3 to to IN cord-013590-pkm81fq1 75 4 this this DT cord-013590-pkm81fq1 75 5 , , , cord-013590-pkm81fq1 75 6 Vδ1 Vδ1 NNP cord-013590-pkm81fq1 75 7 + + CC cord-013590-pkm81fq1 75 8 γδ γδ NN cord-013590-pkm81fq1 75 9 T t NN cord-013590-pkm81fq1 75 10 cells cell NNS cord-013590-pkm81fq1 75 11 derived derive VBN cord-013590-pkm81fq1 75 12 in in IN cord-013590-pkm81fq1 75 13 vitro vitro FW cord-013590-pkm81fq1 75 14 from from IN cord-013590-pkm81fq1 75 15 human human JJ cord-013590-pkm81fq1 75 16 hematopoietic hematopoietic JJ cord-013590-pkm81fq1 75 17 stem stem NN cord-013590-pkm81fq1 75 18 and and CC cord-013590-pkm81fq1 75 19 progenitor progenitor NN cord-013590-pkm81fq1 75 20 cell cell NN cord-013590-pkm81fq1 75 21 ( ( -LRB- cord-013590-pkm81fq1 75 22 HSPC HSPC NNP cord-013590-pkm81fq1 75 23 ) ) -RRB- cord-013590-pkm81fq1 75 24 were be VBD cord-013590-pkm81fq1 75 25 reactive reactive JJ cord-013590-pkm81fq1 75 26 to to IN cord-013590-pkm81fq1 75 27 MHC MHC NNP cord-013590-pkm81fq1 75 28 HLA HLA NNP cord-013590-pkm81fq1 75 29 - - HYPH cord-013590-pkm81fq1 75 30 A2-restricted A2-restricted NNP cord-013590-pkm81fq1 75 31 peptide peptide NN cord-013590-pkm81fq1 75 32 presentation presentation NN cord-013590-pkm81fq1 75 33 of of IN cord-013590-pkm81fq1 75 34 the the DT cord-013590-pkm81fq1 75 35 melanoma melanoma NN cord-013590-pkm81fq1 75 36 antigen antigen NN cord-013590-pkm81fq1 75 37 MART-1 MART-1 NNP cord-013590-pkm81fq1 75 38 . . . cord-013590-pkm81fq1 76 1 34 34 CD cord-013590-pkm81fq1 77 1 However however RB cord-013590-pkm81fq1 77 2 , , , cord-013590-pkm81fq1 77 3 the the DT cord-013590-pkm81fq1 77 4 resolved resolve VBN cord-013590-pkm81fq1 77 5 structure structure NN cord-013590-pkm81fq1 77 6 of of IN cord-013590-pkm81fq1 77 7 the the DT cord-013590-pkm81fq1 77 8 interacting interact VBG cord-013590-pkm81fq1 77 9 proteins protein NNS cord-013590-pkm81fq1 77 10 suggests suggest VBZ cord-013590-pkm81fq1 77 11 that that IN cord-013590-pkm81fq1 77 12 binding binding NN cord-013590-pkm81fq1 77 13 of of IN cord-013590-pkm81fq1 77 14 the the DT cord-013590-pkm81fq1 77 15 respective respective NNS cord-013590-pkm81fq1 77 16 γδ γδ IN cord-013590-pkm81fq1 77 17 TCRs tcr NNS cord-013590-pkm81fq1 77 18 to to IN cord-013590-pkm81fq1 77 19 MART-1 MART-1 NNS cord-013590-pkm81fq1 77 20 presenting present VBG cord-013590-pkm81fq1 77 21 MHC MHC NNP cord-013590-pkm81fq1 77 22 is be VBZ cord-013590-pkm81fq1 77 23 less less RBR cord-013590-pkm81fq1 77 24 peptide peptide NN cord-013590-pkm81fq1 77 25 - - HYPH cord-013590-pkm81fq1 77 26 centric centric NN cord-013590-pkm81fq1 77 27 as as IN cord-013590-pkm81fq1 77 28 compared compare VBN cord-013590-pkm81fq1 77 29 to to IN cord-013590-pkm81fq1 77 30 the the DT cord-013590-pkm81fq1 77 31 interaction interaction NN cord-013590-pkm81fq1 77 32 with with IN cord-013590-pkm81fq1 77 33 a a DT cord-013590-pkm81fq1 77 34 MART-1-specific mart-1-specific NN cord-013590-pkm81fq1 78 1 αβ αβ NNP cord-013590-pkm81fq1 79 1 TCR TCR NNP cord-013590-pkm81fq1 79 2 . . . cord-013590-pkm81fq1 80 1 Hence hence RB cord-013590-pkm81fq1 80 2 , , , cord-013590-pkm81fq1 80 3 one one PRP cord-013590-pkm81fq1 80 4 might may MD cord-013590-pkm81fq1 80 5 speculate speculate VB cord-013590-pkm81fq1 80 6 that that IN cord-013590-pkm81fq1 80 7 MART-1-MHC mart-1-mhc NN cord-013590-pkm81fq1 80 8 - - HYPH cord-013590-pkm81fq1 80 9 specific specific JJ cord-013590-pkm81fq1 80 10 activation activation NN cord-013590-pkm81fq1 80 11 of of IN cord-013590-pkm81fq1 80 12 some some DT cord-013590-pkm81fq1 80 13 γδ γδ XX cord-013590-pkm81fq1 81 1 TCR TCR NNP cord-013590-pkm81fq1 81 2 is be VBZ cord-013590-pkm81fq1 81 3 still still RB cord-013590-pkm81fq1 81 4 different different JJ cord-013590-pkm81fq1 81 5 from from IN cord-013590-pkm81fq1 82 1 classical classical JJ cord-013590-pkm81fq1 82 2 αβ αβ FW cord-013590-pkm81fq1 82 3 TCR TCR NNP cord-013590-pkm81fq1 82 4 MHCrestriction mhcrestriction NN cord-013590-pkm81fq1 82 5 and and CC cord-013590-pkm81fq1 82 6 that that IN cord-013590-pkm81fq1 82 7 MART-1 MART-1 NNP cord-013590-pkm81fq1 82 8 could could MD cord-013590-pkm81fq1 82 9 also also RB cord-013590-pkm81fq1 82 10 be be VB cord-013590-pkm81fq1 82 11 a a DT cord-013590-pkm81fq1 82 12 specific specific JJ cord-013590-pkm81fq1 82 13 stabilizer stabilizer NN cord-013590-pkm81fq1 82 14 for for IN cord-013590-pkm81fq1 82 15 the the DT cord-013590-pkm81fq1 82 16 MHC MHC NNP cord-013590-pkm81fq1 82 17 that that WDT cord-013590-pkm81fq1 82 18 is be VBZ cord-013590-pkm81fq1 82 19 required require VBN cord-013590-pkm81fq1 82 20 for for IN cord-013590-pkm81fq1 82 21 proper proper JJ cord-013590-pkm81fq1 82 22 detection detection NN cord-013590-pkm81fq1 82 23 by by IN cord-013590-pkm81fq1 82 24 the the DT cord-013590-pkm81fq1 82 25 respective respective NNS cord-013590-pkm81fq1 82 26 γδ γδ IN cord-013590-pkm81fq1 82 27 TCRs tcr NNS cord-013590-pkm81fq1 82 28 . . . cord-013590-pkm81fq1 83 1 Besides besides IN cord-013590-pkm81fq1 83 2 classical classical JJ cord-013590-pkm81fq1 83 3 MHC MHC NNP cord-013590-pkm81fq1 83 4 recognition recognition NN cord-013590-pkm81fq1 83 5 some some DT cord-013590-pkm81fq1 83 6 γδ γδ IN cord-013590-pkm81fq1 83 7 TCRs tcr NNS cord-013590-pkm81fq1 83 8 are be VBP cord-013590-pkm81fq1 83 9 reactive reactive JJ cord-013590-pkm81fq1 83 10 towards towards IN cord-013590-pkm81fq1 83 11 MHC MHC NNP cord-013590-pkm81fq1 83 12 class class NN cord-013590-pkm81fq1 83 13 Ib Ib NNP cord-013590-pkm81fq1 83 14 or or CC cord-013590-pkm81fq1 83 15 MHC MHC NNP cord-013590-pkm81fq1 83 16 - - HYPH cord-013590-pkm81fq1 83 17 related relate VBN cord-013590-pkm81fq1 83 18 proteins protein NNS cord-013590-pkm81fq1 83 19 in in IN cord-013590-pkm81fq1 83 20 mice mouse NNS cord-013590-pkm81fq1 83 21 and and CC cord-013590-pkm81fq1 83 22 humans human NNS cord-013590-pkm81fq1 83 23 . . . cord-013590-pkm81fq1 84 1 The the DT cord-013590-pkm81fq1 84 2 lipid lipid NN cord-013590-pkm81fq1 84 3 - - HYPH cord-013590-pkm81fq1 84 4 antigen antigen NN cord-013590-pkm81fq1 84 5 - - HYPH cord-013590-pkm81fq1 84 6 presenting present VBG cord-013590-pkm81fq1 84 7 molecules molecule NNS cord-013590-pkm81fq1 84 8 CD1-c cd1-c RB cord-013590-pkm81fq1 84 9 and and CC cord-013590-pkm81fq1 84 10 CD1-d CD1-d NNP cord-013590-pkm81fq1 84 11 are be VBP cord-013590-pkm81fq1 84 12 amongst amongst IN cord-013590-pkm81fq1 84 13 the the DT cord-013590-pkm81fq1 84 14 best good JJS cord-013590-pkm81fq1 84 15 studied study VBN cord-013590-pkm81fq1 84 16 examples example NNS cord-013590-pkm81fq1 84 17 of of IN cord-013590-pkm81fq1 84 18 this this DT cord-013590-pkm81fq1 84 19 group group NN cord-013590-pkm81fq1 84 20 . . . cord-013590-pkm81fq1 85 1 12 12 CD cord-013590-pkm81fq1 85 2 , , , cord-013590-pkm81fq1 85 3 [ [ -LRB- cord-013590-pkm81fq1 85 4 35 35 CD cord-013590-pkm81fq1 85 5 ] ] -RRB- cord-013590-pkm81fq1 85 6 [ [ -LRB- cord-013590-pkm81fq1 85 7 36 36 CD cord-013590-pkm81fq1 85 8 ] ] -RRB- cord-013590-pkm81fq1 86 1 [ [ -LRB- cord-013590-pkm81fq1 86 2 37 37 CD cord-013590-pkm81fq1 86 3 ] ] -RRB- cord-013590-pkm81fq1 86 4 [ [ -LRB- cord-013590-pkm81fq1 86 5 38 38 CD cord-013590-pkm81fq1 86 6 ] ] -RRB- cord-013590-pkm81fq1 87 1 [ [ -LRB- cord-013590-pkm81fq1 87 2 39 39 CD cord-013590-pkm81fq1 87 3 ] ] -RRB- cord-013590-pkm81fq1 87 4 Human Human NNP cord-013590-pkm81fq1 87 5 γδ γδ IN cord-013590-pkm81fq1 87 6 TCRs tcr NNS cord-013590-pkm81fq1 87 7 recognizing recognize VBG cord-013590-pkm81fq1 87 8 CD1-molecules cd1-molecule NNS cord-013590-pkm81fq1 87 9 are be VBP cord-013590-pkm81fq1 87 10 Vδ1 Vδ1 NNP cord-013590-pkm81fq1 87 11 + + SYM cord-013590-pkm81fq1 87 12 24 24 CD cord-013590-pkm81fq1 87 13 or or CC cord-013590-pkm81fq1 87 14 Vδ3 vδ3 NN cord-013590-pkm81fq1 87 15 + + SYM cord-013590-pkm81fq1 87 16 40 40 CD cord-013590-pkm81fq1 87 17 and and CC cord-013590-pkm81fq1 87 18 they -PRON- PRP cord-013590-pkm81fq1 87 19 can can MD cord-013590-pkm81fq1 87 20 react react VB cord-013590-pkm81fq1 87 21 to to IN cord-013590-pkm81fq1 87 22 several several JJ cord-013590-pkm81fq1 87 23 presented present VBN cord-013590-pkm81fq1 87 24 phospho phospho NN cord-013590-pkm81fq1 87 25 - - HYPH cord-013590-pkm81fq1 87 26 and and CC cord-013590-pkm81fq1 87 27 glycolipids glycolipid NNS cord-013590-pkm81fq1 87 28 . . . cord-013590-pkm81fq1 88 1 12 12 CD cord-013590-pkm81fq1 88 2 , , , cord-013590-pkm81fq1 88 3 36 36 CD cord-013590-pkm81fq1 88 4 However however RB cord-013590-pkm81fq1 88 5 , , , cord-013590-pkm81fq1 88 6 unloaded unload VBN cord-013590-pkm81fq1 88 7 CD1-d CD1-d NNP cord-013590-pkm81fq1 88 8 was be VBD cord-013590-pkm81fq1 88 9 also also RB cord-013590-pkm81fq1 88 10 able able JJ cord-013590-pkm81fq1 88 11 to to TO cord-013590-pkm81fq1 88 12 bind bind VB cord-013590-pkm81fq1 88 13 to to IN cord-013590-pkm81fq1 88 14 Vδ1 vδ1 NN cord-013590-pkm81fq1 88 15 + + . cord-013590-pkm81fq1 89 1 γδ γδ CC cord-013590-pkm81fq1 89 2 TCRs TCRs NNPS cord-013590-pkm81fq1 89 3 albeit albeit IN cord-013590-pkm81fq1 89 4 with with IN cord-013590-pkm81fq1 89 5 lower low JJR cord-013590-pkm81fq1 89 6 affinity affinity NN cord-013590-pkm81fq1 89 7 than than IN cord-013590-pkm81fq1 89 8 if if IN cord-013590-pkm81fq1 89 9 presenting present VBG cord-013590-pkm81fq1 89 10 lipids lipid NNS cord-013590-pkm81fq1 89 11 , , , cord-013590-pkm81fq1 89 12 24 24 CD cord-013590-pkm81fq1 89 13 which which WDT cord-013590-pkm81fq1 89 14 would would MD cord-013590-pkm81fq1 89 15 be be VB cord-013590-pkm81fq1 89 16 in in IN cord-013590-pkm81fq1 89 17 - - HYPH cord-013590-pkm81fq1 89 18 line line NN cord-013590-pkm81fq1 89 19 with with IN cord-013590-pkm81fq1 89 20 the the DT cord-013590-pkm81fq1 89 21 mentioned mention VBN cord-013590-pkm81fq1 89 22 alloreactivity alloreactivity NN cord-013590-pkm81fq1 89 23 observed observe VBD cord-013590-pkm81fq1 89 24 in in IN cord-013590-pkm81fq1 89 25 MHC MHC NNP cord-013590-pkm81fq1 89 26 - - HYPH cord-013590-pkm81fq1 89 27 reactive reactive JJ cord-013590-pkm81fq1 89 28 γδ γδ IN cord-013590-pkm81fq1 89 29 TCRs tcr NNS cord-013590-pkm81fq1 89 30 . . . cord-013590-pkm81fq1 90 1 Another another DT cord-013590-pkm81fq1 90 2 MHC MHC NNP cord-013590-pkm81fq1 90 3 - - HYPH cord-013590-pkm81fq1 90 4 Ib Ib NNP cord-013590-pkm81fq1 90 5 molecule molecule NN cord-013590-pkm81fq1 90 6 that that WDT cord-013590-pkm81fq1 90 7 is be VBZ cord-013590-pkm81fq1 90 8 a a DT cord-013590-pkm81fq1 90 9 putative putative JJ cord-013590-pkm81fq1 90 10 ligand ligand NN cord-013590-pkm81fq1 90 11 for for IN cord-013590-pkm81fq1 90 12 the the DT cord-013590-pkm81fq1 90 13 γδ γδ NN cord-013590-pkm81fq1 91 1 TCR TCR NNP cord-013590-pkm81fq1 91 2 is be VBZ cord-013590-pkm81fq1 91 3 murine murine JJ cord-013590-pkm81fq1 91 4 Qa-1 Qa-1 NNP cord-013590-pkm81fq1 91 5 b b NNP cord-013590-pkm81fq1 91 6 presenting present VBG cord-013590-pkm81fq1 91 7 an an DT cord-013590-pkm81fq1 91 8 artificial artificial JJ cord-013590-pkm81fq1 91 9 glutamine glutamine NN cord-013590-pkm81fq1 91 10 - - HYPH cord-013590-pkm81fq1 91 11 tyrosine tyrosine NN cord-013590-pkm81fq1 91 12 polypeptide polypeptide NN cord-013590-pkm81fq1 91 13 . . . cord-013590-pkm81fq1 92 1 41 41 CD cord-013590-pkm81fq1 93 1 In in IN cord-013590-pkm81fq1 93 2 addition addition NN cord-013590-pkm81fq1 93 3 , , , cord-013590-pkm81fq1 93 4 in in IN cord-013590-pkm81fq1 93 5 vivo vivo NN cord-013590-pkm81fq1 93 6 expansion expansion NN cord-013590-pkm81fq1 93 7 of of IN cord-013590-pkm81fq1 93 8 γδ γδ NNP cord-013590-pkm81fq1 93 9 IELs iel NNS cord-013590-pkm81fq1 93 10 in in IN cord-013590-pkm81fq1 93 11 response response NN cord-013590-pkm81fq1 93 12 to to IN cord-013590-pkm81fq1 93 13 Salmonella Salmonella NNP cord-013590-pkm81fq1 93 14 infection infection NN cord-013590-pkm81fq1 93 15 was be VBD cord-013590-pkm81fq1 93 16 dependent dependent JJ cord-013590-pkm81fq1 93 17 on on IN cord-013590-pkm81fq1 93 18 peptide peptide NN cord-013590-pkm81fq1 93 19 loading loading NN cord-013590-pkm81fq1 93 20 of of IN cord-013590-pkm81fq1 93 21 Qa-1 Qa-1 NNP cord-013590-pkm81fq1 93 22 b b NNP cord-013590-pkm81fq1 93 23 . . . cord-013590-pkm81fq1 94 1 42 42 CD cord-013590-pkm81fq1 95 1 Yet yet RB cord-013590-pkm81fq1 95 2 , , , cord-013590-pkm81fq1 95 3 unambiguous unambiguous JJ cord-013590-pkm81fq1 95 4 evidence evidence NN cord-013590-pkm81fq1 95 5 that that IN cord-013590-pkm81fq1 95 6 physiological physiological JJ cord-013590-pkm81fq1 95 7 peptides peptide NNS cord-013590-pkm81fq1 95 8 bound bind VBN cord-013590-pkm81fq1 95 9 to to IN cord-013590-pkm81fq1 95 10 Qa-1 Qa-1 NNP cord-013590-pkm81fq1 95 11 b b NNP cord-013590-pkm81fq1 95 12 are be VBP cord-013590-pkm81fq1 95 13 specifically specifically RB cord-013590-pkm81fq1 95 14 recognized recognize VBN cord-013590-pkm81fq1 95 15 by by IN cord-013590-pkm81fq1 95 16 γδ γδ IN cord-013590-pkm81fq1 95 17 TCRs TCRs NNP cord-013590-pkm81fq1 95 18 does do VBZ cord-013590-pkm81fq1 95 19 not not RB cord-013590-pkm81fq1 95 20 exist exist VB cord-013590-pkm81fq1 95 21 and and CC cord-013590-pkm81fq1 95 22 a a DT cord-013590-pkm81fq1 95 23 mere mere JJ cord-013590-pkm81fq1 95 24 stabilizing stabilize VBG cord-013590-pkm81fq1 95 25 function function NN cord-013590-pkm81fq1 95 26 as as IN cord-013590-pkm81fq1 95 27 in in IN cord-013590-pkm81fq1 95 28 the the DT cord-013590-pkm81fq1 95 29 case case NN cord-013590-pkm81fq1 95 30 of of IN cord-013590-pkm81fq1 95 31 human human JJ cord-013590-pkm81fq1 95 32 HLA HLA NNP cord-013590-pkm81fq1 95 33 * * NFP cord-013590-pkm81fq1 95 34 24:02 24:02 CD cord-013590-pkm81fq1 95 35 can can MD cord-013590-pkm81fq1 95 36 not not RB cord-013590-pkm81fq1 95 37 be be VB cord-013590-pkm81fq1 95 38 excluded exclude VBN cord-013590-pkm81fq1 95 39 . . . cord-013590-pkm81fq1 96 1 23 23 CD cord-013590-pkm81fq1 96 2 Other other JJ cord-013590-pkm81fq1 96 3 functional functional JJ cord-013590-pkm81fq1 96 4 interactions interaction NNS cord-013590-pkm81fq1 96 5 of of IN cord-013590-pkm81fq1 96 6 γδ γδ NNP cord-013590-pkm81fq1 96 7 TCRs tcr NNS cord-013590-pkm81fq1 96 8 with with IN cord-013590-pkm81fq1 96 9 MHC MHC NNP cord-013590-pkm81fq1 96 10 - - HYPH cord-013590-pkm81fq1 96 11 like like JJ cord-013590-pkm81fq1 96 12 molecules molecule NNS cord-013590-pkm81fq1 96 13 do do VBP cord-013590-pkm81fq1 96 14 not not RB cord-013590-pkm81fq1 96 15 require require VB cord-013590-pkm81fq1 96 16 the the DT cord-013590-pkm81fq1 96 17 presentation presentation NN cord-013590-pkm81fq1 96 18 of of IN cord-013590-pkm81fq1 96 19 antigens antigen NNS cord-013590-pkm81fq1 96 20 as as IN cord-013590-pkm81fq1 96 21 is be VBZ cord-013590-pkm81fq1 96 22 the the DT cord-013590-pkm81fq1 96 23 case case NN cord-013590-pkm81fq1 96 24 for for IN cord-013590-pkm81fq1 96 25 MHC MHC NNP cord-013590-pkm81fq1 96 26 - - HYPH cord-013590-pkm81fq1 96 27 related relate VBN cord-013590-pkm81fq1 96 28 protein protein NN cord-013590-pkm81fq1 96 29 1 1 CD cord-013590-pkm81fq1 96 30 ( ( -LRB- cord-013590-pkm81fq1 96 31 MR-1 MR-1 NNP cord-013590-pkm81fq1 96 32 ) ) -RRB- cord-013590-pkm81fq1 96 33 , , , cord-013590-pkm81fq1 96 34 43 43 CD cord-013590-pkm81fq1 96 35 endothelial endothelial JJ cord-013590-pkm81fq1 96 36 protein protein NN cord-013590-pkm81fq1 96 37 C c NN cord-013590-pkm81fq1 96 38 receptor receptor NN cord-013590-pkm81fq1 96 39 ( ( -LRB- cord-013590-pkm81fq1 96 40 EPCR EPCR NNP cord-013590-pkm81fq1 96 41 ) ) -RRB- cord-013590-pkm81fq1 96 42 , , , cord-013590-pkm81fq1 96 43 25 25 CD cord-013590-pkm81fq1 96 44 MHC MHC NNP cord-013590-pkm81fq1 96 45 class class NN cord-013590-pkm81fq1 96 46 I i NN cord-013590-pkm81fq1 96 47 - - HYPH cord-013590-pkm81fq1 96 48 related relate VBN cord-013590-pkm81fq1 96 49 Chain Chain NNP cord-013590-pkm81fq1 96 50 A A NNP cord-013590-pkm81fq1 96 51 or or CC cord-013590-pkm81fq1 96 52 B b NN cord-013590-pkm81fq1 96 53 ( ( -LRB- cord-013590-pkm81fq1 96 54 MICA/ MICA/ NNP cord-013590-pkm81fq1 96 55 MICB MICB NNP cord-013590-pkm81fq1 96 56 ) ) -RRB- cord-013590-pkm81fq1 96 57 , , , cord-013590-pkm81fq1 96 58 10,44 10,44 CD cord-013590-pkm81fq1 96 59 - - SYM cord-013590-pkm81fq1 96 60 46 46 CD cord-013590-pkm81fq1 97 1 UL16-binding ul16-binding NN cord-013590-pkm81fq1 98 1 protein protein NN cord-013590-pkm81fq1 98 2 4 4 CD cord-013590-pkm81fq1 98 3 ( ( -LRB- cord-013590-pkm81fq1 98 4 ULBP4 ulbp4 NN cord-013590-pkm81fq1 98 5 ) ) -RRB- cord-013590-pkm81fq1 98 6 13 13 CD cord-013590-pkm81fq1 98 7 and and CC cord-013590-pkm81fq1 98 8 T10 T10 NNP cord-013590-pkm81fq1 98 9 / / SYM cord-013590-pkm81fq1 98 10 T22 T22 NNP cord-013590-pkm81fq1 98 11 in in IN cord-013590-pkm81fq1 98 12 mice mouse NNS cord-013590-pkm81fq1 98 13 . . . cord-013590-pkm81fq1 99 1 [ [ -LRB- cord-013590-pkm81fq1 99 2 47 47 CD cord-013590-pkm81fq1 99 3 ] ] -RRB- cord-013590-pkm81fq1 99 4 [ [ -LRB- cord-013590-pkm81fq1 99 5 48 48 CD cord-013590-pkm81fq1 99 6 ] ] -RRB- cord-013590-pkm81fq1 100 1 [ [ -LRB- cord-013590-pkm81fq1 100 2 49 49 CD cord-013590-pkm81fq1 100 3 ] ] -RRB- cord-013590-pkm81fq1 101 1 [ [ -LRB- cord-013590-pkm81fq1 101 2 50 50 CD cord-013590-pkm81fq1 101 3 ] ] -RRB- cord-013590-pkm81fq1 102 1 The the DT cord-013590-pkm81fq1 102 2 reasons reason NNS cord-013590-pkm81fq1 102 3 are be VBP cord-013590-pkm81fq1 102 4 that that IN cord-013590-pkm81fq1 102 5 either either CC cord-013590-pkm81fq1 102 6 the the DT cord-013590-pkm81fq1 102 7 reactive reactive JJ cord-013590-pkm81fq1 102 8 γδ γδ IN cord-013590-pkm81fq1 102 9 TCRs tcr NNS cord-013590-pkm81fq1 102 10 are be VBP cord-013590-pkm81fq1 102 11 binding bind VBG cord-013590-pkm81fq1 102 12 independently independently RB cord-013590-pkm81fq1 102 13 of of IN cord-013590-pkm81fq1 102 14 the the DT cord-013590-pkm81fq1 102 15 presented present VBN cord-013590-pkm81fq1 102 16 antigen antigen NN cord-013590-pkm81fq1 102 17 ( ( -LRB- cord-013590-pkm81fq1 102 18 MR-1 MR-1 NNP cord-013590-pkm81fq1 102 19 ) ) -RRB- cord-013590-pkm81fq1 102 20 , , , cord-013590-pkm81fq1 102 21 no no DT cord-013590-pkm81fq1 102 22 further further JJ cord-013590-pkm81fq1 102 23 molecules molecule NNS cord-013590-pkm81fq1 102 24 are be VBP cord-013590-pkm81fq1 102 25 presented present VBN cord-013590-pkm81fq1 102 26 ( ( -LRB- cord-013590-pkm81fq1 102 27 EPCR EPCR NNP cord-013590-pkm81fq1 102 28 ) ) -RRB- cord-013590-pkm81fq1 102 29 or or CC cord-013590-pkm81fq1 102 30 the the DT cord-013590-pkm81fq1 102 31 antigen antigen NN cord-013590-pkm81fq1 102 32 - - HYPH cord-013590-pkm81fq1 102 33 binding bind VBG cord-013590-pkm81fq1 102 34 cleft cleft NN cord-013590-pkm81fq1 102 35 of of IN cord-013590-pkm81fq1 102 36 the the DT cord-013590-pkm81fq1 102 37 respective respective JJ cord-013590-pkm81fq1 102 38 ligand ligand NN cord-013590-pkm81fq1 102 39 is be VBZ cord-013590-pkm81fq1 102 40 truncated truncate VBN cord-013590-pkm81fq1 102 41 , , , cord-013590-pkm81fq1 102 42 which which WDT cord-013590-pkm81fq1 102 43 precludes preclude VBZ cord-013590-pkm81fq1 102 44 the the DT cord-013590-pkm81fq1 102 45 loading loading NN cord-013590-pkm81fq1 102 46 of of IN cord-013590-pkm81fq1 102 47 antigen antigen NN cord-013590-pkm81fq1 102 48 ( ( -LRB- cord-013590-pkm81fq1 102 49 T10 T10 NNP cord-013590-pkm81fq1 102 50 / / SYM cord-013590-pkm81fq1 102 51 T22 T22 NNP cord-013590-pkm81fq1 102 52 ) ) -RRB- cord-013590-pkm81fq1 102 53 . . . cord-013590-pkm81fq1 103 1 Thus thus RB cord-013590-pkm81fq1 103 2 , , , cord-013590-pkm81fq1 103 3 overall overall RB cord-013590-pkm81fq1 103 4 γδ γδ IN cord-013590-pkm81fq1 103 5 TCR TCR NNP cord-013590-pkm81fq1 103 6 recognition recognition NN cord-013590-pkm81fq1 103 7 of of IN cord-013590-pkm81fq1 103 8 classical classical JJ cord-013590-pkm81fq1 103 9 MHC MHC NNP cord-013590-pkm81fq1 103 10 or or CC cord-013590-pkm81fq1 103 11 MHC MHC NNP cord-013590-pkm81fq1 103 12 - - HYPH cord-013590-pkm81fq1 103 13 like like JJ cord-013590-pkm81fq1 103 14 molecules molecule NNS cord-013590-pkm81fq1 103 15 seems seem VBZ cord-013590-pkm81fq1 103 16 to to TO cord-013590-pkm81fq1 103 17 be be VB cord-013590-pkm81fq1 103 18 independent independent JJ cord-013590-pkm81fq1 103 19 of of IN cord-013590-pkm81fq1 103 20 the the DT cord-013590-pkm81fq1 103 21 presentation presentation NN cord-013590-pkm81fq1 103 22 of of IN cord-013590-pkm81fq1 103 23 foreign foreign JJ cord-013590-pkm81fq1 103 24 antigens antigen NNS cord-013590-pkm81fq1 103 25 , , , cord-013590-pkm81fq1 103 26 which which WDT cord-013590-pkm81fq1 103 27 is be VBZ cord-013590-pkm81fq1 103 28 in in IN cord-013590-pkm81fq1 103 29 contrast contrast NN cord-013590-pkm81fq1 103 30 to to IN cord-013590-pkm81fq1 103 31 αβ αβ NN cord-013590-pkm81fq1 103 32 TCR TCR NNP cord-013590-pkm81fq1 103 33 antigen antigen NN cord-013590-pkm81fq1 103 34 binding binding NN cord-013590-pkm81fq1 103 35 . . . cord-013590-pkm81fq1 104 1 Reactivity reactivity NN cord-013590-pkm81fq1 104 2 of of IN cord-013590-pkm81fq1 104 3 γδ γδ NNP cord-013590-pkm81fq1 104 4 TCRs tcr NNS cord-013590-pkm81fq1 104 5 to to IN cord-013590-pkm81fq1 104 6 MHC MHC NNP cord-013590-pkm81fq1 104 7 or or CC cord-013590-pkm81fq1 104 8 MHC MHC NNP cord-013590-pkm81fq1 104 9 - - HYPH cord-013590-pkm81fq1 104 10 like like JJ cord-013590-pkm81fq1 104 11 molecules molecule NNS cord-013590-pkm81fq1 104 12 is be VBZ cord-013590-pkm81fq1 104 13 largely largely RB cord-013590-pkm81fq1 104 14 dependent dependent JJ cord-013590-pkm81fq1 104 15 on on IN cord-013590-pkm81fq1 104 16 the the DT cord-013590-pkm81fq1 104 17 CDRs cdr NNS cord-013590-pkm81fq1 104 18 with with IN cord-013590-pkm81fq1 104 19 a a DT cord-013590-pkm81fq1 104 20 substantial substantial JJ cord-013590-pkm81fq1 104 21 focus focus NN cord-013590-pkm81fq1 104 22 on on IN cord-013590-pkm81fq1 104 23 the the DT cord-013590-pkm81fq1 104 24 CDR3δ CDR3δ NNP cord-013590-pkm81fq1 104 25 in in IN cord-013590-pkm81fq1 104 26 most most JJS cord-013590-pkm81fq1 104 27 cases case NNS cord-013590-pkm81fq1 105 1 ( ( -LRB- cord-013590-pkm81fq1 105 2 T10 T10 NNP cord-013590-pkm81fq1 105 3 / / SYM cord-013590-pkm81fq1 105 4 T22 T22 NNP cord-013590-pkm81fq1 105 5 , , , cord-013590-pkm81fq1 105 6 CD1-d CD1-d NNP cord-013590-pkm81fq1 105 7 , , , cord-013590-pkm81fq1 105 8 MART-1 MART-1 NNP cord-013590-pkm81fq1 105 9 HLA HLA NNP cord-013590-pkm81fq1 105 10 - - HYPH cord-013590-pkm81fq1 105 11 A2 A2 NNP cord-013590-pkm81fq1 105 12 ) ) -RRB- cord-013590-pkm81fq1 105 13 and and CC cord-013590-pkm81fq1 105 14 the the DT cord-013590-pkm81fq1 105 15 TCR TCR NNP cord-013590-pkm81fq1 105 16 - - HYPH cord-013590-pkm81fq1 105 17 chains chain NNS cord-013590-pkm81fq1 105 18 are be VBP cord-013590-pkm81fq1 105 19 commonly commonly RB cord-013590-pkm81fq1 105 20 composed compose VBN cord-013590-pkm81fq1 105 21 of of IN cord-013590-pkm81fq1 105 22 Vδ2 Vδ2 NNP cord-013590-pkm81fq1 105 23 − − CD cord-013590-pkm81fq1 106 1 -or -or : cord-013590-pkm81fq1 107 1 Vγ9 Vγ9 NNP cord-013590-pkm81fq1 107 2 − − NNP cord-013590-pkm81fq1 107 3 Vδ2 Vδ2 VBD cord-013590-pkm81fq1 107 4 + + SYM cord-013590-pkm81fq1 107 5 sequences sequence NNS cord-013590-pkm81fq1 107 6 . . . cord-013590-pkm81fq1 108 1 Furthermore furthermore RB cord-013590-pkm81fq1 108 2 , , , cord-013590-pkm81fq1 108 3 reactive reactive JJ cord-013590-pkm81fq1 108 4 TCRs tcr NNS cord-013590-pkm81fq1 108 5 were be VBD cord-013590-pkm81fq1 108 6 usually usually RB cord-013590-pkm81fq1 108 7 derived derive VBN cord-013590-pkm81fq1 108 8 from from IN cord-013590-pkm81fq1 108 9 particular particular JJ cord-013590-pkm81fq1 108 10 private private JJ cord-013590-pkm81fq1 108 11 clones clone NNS cord-013590-pkm81fq1 108 12 ( ( -LRB- cord-013590-pkm81fq1 108 13 EPCR EPCR NNP cord-013590-pkm81fq1 108 14 , , , cord-013590-pkm81fq1 108 15 HLA HLA NNP cord-013590-pkm81fq1 108 16 * * NFP cord-013590-pkm81fq1 108 17 24:02 24:02 CD cord-013590-pkm81fq1 108 18 ) ) -RRB- cord-013590-pkm81fq1 108 19 that that WDT cord-013590-pkm81fq1 108 20 were be VBD cord-013590-pkm81fq1 108 21 not not RB cord-013590-pkm81fq1 108 22 shared share VBN cord-013590-pkm81fq1 108 23 between between IN cord-013590-pkm81fq1 108 24 individuals individual NNS cord-013590-pkm81fq1 108 25 or or CC cord-013590-pkm81fq1 108 26 were be VBD cord-013590-pkm81fq1 108 27 of of IN cord-013590-pkm81fq1 108 28 low low JJ cord-013590-pkm81fq1 108 29 abundance abundance NN cord-013590-pkm81fq1 108 30 in in IN cord-013590-pkm81fq1 108 31 peripheral peripheral JJ cord-013590-pkm81fq1 108 32 blood blood NN cord-013590-pkm81fq1 108 33 ( ( -LRB- cord-013590-pkm81fq1 108 34 MR-1 MR-1 NNP cord-013590-pkm81fq1 108 35 , , , cord-013590-pkm81fq1 108 36 CD1 CD1 NNP cord-013590-pkm81fq1 108 37 , , , cord-013590-pkm81fq1 108 38 T10 T10 NNP cord-013590-pkm81fq1 108 39 / / SYM cord-013590-pkm81fq1 108 40 T22 T22 NNP cord-013590-pkm81fq1 108 41 ) ) -RRB- cord-013590-pkm81fq1 108 42 . . . cord-013590-pkm81fq1 109 1 However however RB cord-013590-pkm81fq1 109 2 , , , cord-013590-pkm81fq1 109 3 γδ γδ NNP cord-013590-pkm81fq1 109 4 TCR TCR NNP cord-013590-pkm81fq1 109 5 repertoire repertoire NN cord-013590-pkm81fq1 109 6 analysis analysis NN cord-013590-pkm81fq1 109 7 revealed reveal VBD cord-013590-pkm81fq1 109 8 that that IN cord-013590-pkm81fq1 109 9 clones clone NNS cord-013590-pkm81fq1 109 10 of of IN cord-013590-pkm81fq1 109 11 the the DT cord-013590-pkm81fq1 109 12 Vδ2 Vδ2 NNP cord-013590-pkm81fq1 109 13 − − NNP cord-013590-pkm81fq1 109 14 -or -or . cord-013590-pkm81fq1 110 1 Vγ9 Vγ9 NNP cord-013590-pkm81fq1 110 2 − − NNP cord-013590-pkm81fq1 110 3 Vδ2 Vδ2 VBD cord-013590-pkm81fq1 110 4 + + . cord-013590-pkm81fq1 111 1 subsets subset NNS cord-013590-pkm81fq1 111 2 can can MD cord-013590-pkm81fq1 111 3 undergo undergo VB cord-013590-pkm81fq1 111 4 rapid rapid JJ cord-013590-pkm81fq1 111 5 and and CC cord-013590-pkm81fq1 111 6 sustained sustained JJ cord-013590-pkm81fq1 111 7 clonal clonal JJ cord-013590-pkm81fq1 111 8 expansion expansion NN cord-013590-pkm81fq1 111 9 in in IN cord-013590-pkm81fq1 111 10 response response NN cord-013590-pkm81fq1 111 11 to to IN cord-013590-pkm81fq1 111 12 e.g. e.g. RB cord-013590-pkm81fq1 111 13 , , , cord-013590-pkm81fq1 111 14 CMV CMV NNP cord-013590-pkm81fq1 111 15 infection infection NN cord-013590-pkm81fq1 111 16 14 14 CD cord-013590-pkm81fq1 111 17 , , , cord-013590-pkm81fq1 111 18 15 15 CD cord-013590-pkm81fq1 111 19 and and CC cord-013590-pkm81fq1 111 20 MART-1-HLA MART-1-HLA NNP cord-013590-pkm81fq1 111 21 - - HYPH cord-013590-pkm81fq1 111 22 A2 A2 NNP cord-013590-pkm81fq1 112 1 reactive reactive JJ cord-013590-pkm81fq1 113 1 γδ γδ CC cord-013590-pkm81fq1 113 2 T t NN cord-013590-pkm81fq1 113 3 cells cell NNS cord-013590-pkm81fq1 113 4 could could MD cord-013590-pkm81fq1 113 5 be be VB cord-013590-pkm81fq1 113 6 expanded expand VBN cord-013590-pkm81fq1 113 7 from from IN cord-013590-pkm81fq1 113 8 PBMCs pbmc NNS cord-013590-pkm81fq1 113 9 in in IN cord-013590-pkm81fq1 113 10 vitro vitro FW cord-013590-pkm81fq1 113 11 . . . cord-013590-pkm81fq1 114 1 34 34 CD cord-013590-pkm81fq1 115 1 These these DT cord-013590-pkm81fq1 115 2 features feature NNS cord-013590-pkm81fq1 115 3 of of IN cord-013590-pkm81fq1 115 4 MHC MHC NNP cord-013590-pkm81fq1 115 5 - - : cord-013590-pkm81fq1 115 6 and and CC cord-013590-pkm81fq1 115 7 MHC MHC NNP cord-013590-pkm81fq1 115 8 - - HYPH cord-013590-pkm81fq1 115 9 like like JJ cord-013590-pkm81fq1 115 10 - - HYPH cord-013590-pkm81fq1 115 11 reactive reactive JJ cord-013590-pkm81fq1 115 12 γδ γδ IN cord-013590-pkm81fq1 115 13 TCRs tcr NNS cord-013590-pkm81fq1 115 14 are be VBP cord-013590-pkm81fq1 115 15 reminiscent reminiscent JJ cord-013590-pkm81fq1 115 16 of of IN cord-013590-pkm81fq1 115 17 the the DT cord-013590-pkm81fq1 115 18 adaptive adaptive JJ cord-013590-pkm81fq1 115 19 responses response NNS cord-013590-pkm81fq1 115 20 observed observe VBN cord-013590-pkm81fq1 115 21 in in IN cord-013590-pkm81fq1 115 22 αβ αβ FW cord-013590-pkm81fq1 115 23 T t NN cord-013590-pkm81fq1 115 24 cells cell NNS cord-013590-pkm81fq1 115 25 , , , cord-013590-pkm81fq1 115 26 hence hence RB cord-013590-pkm81fq1 115 27 this this DT cord-013590-pkm81fq1 115 28 type type NN cord-013590-pkm81fq1 115 29 of of IN cord-013590-pkm81fq1 115 30 antigen antigen NN cord-013590-pkm81fq1 115 31 recognition recognition NN cord-013590-pkm81fq1 115 32 in in IN cord-013590-pkm81fq1 115 33 γδ γδ IN cord-013590-pkm81fq1 115 34 TCRs TCRs NNP cord-013590-pkm81fq1 115 35 was be VBD cord-013590-pkm81fq1 115 36 termed term VBN cord-013590-pkm81fq1 115 37 adaptive adaptive JJ cord-013590-pkm81fq1 115 38 as as IN cord-013590-pkm81fq1 115 39 has have VBZ cord-013590-pkm81fq1 115 40 been be VBN cord-013590-pkm81fq1 115 41 reviewed review VBN cord-013590-pkm81fq1 115 42 by by IN cord-013590-pkm81fq1 115 43 Willcox Willcox NNP cord-013590-pkm81fq1 115 44 & & CC cord-013590-pkm81fq1 115 45 Willcox Willcox NNP cord-013590-pkm81fq1 115 46 18 18 CD cord-013590-pkm81fq1 115 47 as as RB cord-013590-pkm81fq1 115 48 well well RB cord-013590-pkm81fq1 115 49 as as IN cord-013590-pkm81fq1 115 50 Davey Davey NNP cord-013590-pkm81fq1 115 51 et et NNP cord-013590-pkm81fq1 115 52 al al NNP cord-013590-pkm81fq1 115 53 . . . cord-013590-pkm81fq1 116 1 51 51 CD cord-013590-pkm81fq1 116 2 , , , cord-013590-pkm81fq1 116 3 52 52 CD cord-013590-pkm81fq1 117 1 As as IN cord-013590-pkm81fq1 117 2 a a DT cord-013590-pkm81fq1 117 3 consequence consequence NN cord-013590-pkm81fq1 117 4 , , , cord-013590-pkm81fq1 117 5 it -PRON- PRP cord-013590-pkm81fq1 117 6 is be VBZ cord-013590-pkm81fq1 117 7 often often RB cord-013590-pkm81fq1 117 8 difficult difficult JJ cord-013590-pkm81fq1 117 9 to to TO cord-013590-pkm81fq1 117 10 judge judge VB cord-013590-pkm81fq1 117 11 whether whether IN cord-013590-pkm81fq1 117 12 the the DT cord-013590-pkm81fq1 117 13 ligand ligand NN cord-013590-pkm81fq1 117 14 - - HYPH cord-013590-pkm81fq1 117 15 specificities specificity NNS cord-013590-pkm81fq1 117 16 observed observe VBN cord-013590-pkm81fq1 117 17 are be VBP cord-013590-pkm81fq1 117 18 a a DT cord-013590-pkm81fq1 117 19 general general JJ cord-013590-pkm81fq1 117 20 phenomenon phenomenon NN cord-013590-pkm81fq1 117 21 that that WDT cord-013590-pkm81fq1 117 22 is be VBZ cord-013590-pkm81fq1 117 23 particularly particularly RB cord-013590-pkm81fq1 117 24 relevant relevant JJ cord-013590-pkm81fq1 117 25 , , , cord-013590-pkm81fq1 117 26 since since IN cord-013590-pkm81fq1 117 27 most most JJS cord-013590-pkm81fq1 117 28 of of IN cord-013590-pkm81fq1 117 29 the the DT cord-013590-pkm81fq1 117 30 interactions interaction NNS cord-013590-pkm81fq1 117 31 were be VBD cord-013590-pkm81fq1 117 32 identified identify VBN cord-013590-pkm81fq1 117 33 in in IN cord-013590-pkm81fq1 117 34 cell cell NN cord-013590-pkm81fq1 117 35 culture culture NN cord-013590-pkm81fq1 117 36 systems system NNS cord-013590-pkm81fq1 117 37 in in IN cord-013590-pkm81fq1 117 38 vitro vitro FW cord-013590-pkm81fq1 117 39 and and CC cord-013590-pkm81fq1 117 40 , , , cord-013590-pkm81fq1 117 41 so so RB cord-013590-pkm81fq1 117 42 far far RB cord-013590-pkm81fq1 117 43 , , , cord-013590-pkm81fq1 117 44 evidence evidence NN cord-013590-pkm81fq1 117 45 for for IN cord-013590-pkm81fq1 117 46 physiological physiological JJ cord-013590-pkm81fq1 117 47 relevance relevance NN cord-013590-pkm81fq1 117 48 is be VBZ cord-013590-pkm81fq1 117 49 still still RB cord-013590-pkm81fq1 117 50 rare rare JJ cord-013590-pkm81fq1 117 51 . . . cord-013590-pkm81fq1 118 1 On on IN cord-013590-pkm81fq1 118 2 the the DT cord-013590-pkm81fq1 118 3 other other JJ cord-013590-pkm81fq1 118 4 hand hand NN cord-013590-pkm81fq1 118 5 , , , cord-013590-pkm81fq1 118 6 also also RB cord-013590-pkm81fq1 118 7 in in IN cord-013590-pkm81fq1 118 8 αβ αβ FW cord-013590-pkm81fq1 118 9 T t NN cord-013590-pkm81fq1 118 10 cells cell NNS cord-013590-pkm81fq1 118 11 the the DT cord-013590-pkm81fq1 118 12 amount amount NN cord-013590-pkm81fq1 118 13 of of IN cord-013590-pkm81fq1 118 14 particular particular JJ cord-013590-pkm81fq1 118 15 antigen antigen NN cord-013590-pkm81fq1 118 16 - - HYPH cord-013590-pkm81fq1 118 17 specific specific JJ cord-013590-pkm81fq1 118 18 clones clone NNS cord-013590-pkm81fq1 118 19 is be VBZ cord-013590-pkm81fq1 118 20 low low JJ cord-013590-pkm81fq1 118 21 prior prior RB cord-013590-pkm81fq1 118 22 to to IN cord-013590-pkm81fq1 118 23 expansion expansion NN cord-013590-pkm81fq1 118 24 and and CC cord-013590-pkm81fq1 118 25 it -PRON- PRP cord-013590-pkm81fq1 118 26 is be VBZ cord-013590-pkm81fq1 118 27 conceivable conceivable JJ cord-013590-pkm81fq1 118 28 that that DT cord-013590-pkm81fq1 118 29 antigennaïve antigennaïve JJ cord-013590-pkm81fq1 118 30 but but CC cord-013590-pkm81fq1 118 31 potentially potentially RB cord-013590-pkm81fq1 118 32 reactive reactive JJ cord-013590-pkm81fq1 118 33 γδ γδ IN cord-013590-pkm81fq1 118 34 T t NN cord-013590-pkm81fq1 118 35 cells cell NNS cord-013590-pkm81fq1 118 36 present present JJ cord-013590-pkm81fq1 118 37 at at IN cord-013590-pkm81fq1 118 38 low low JJ cord-013590-pkm81fq1 118 39 frequencies frequency NNS cord-013590-pkm81fq1 118 40 would would MD cord-013590-pkm81fq1 118 41 expand expand VB cord-013590-pkm81fq1 118 42 upon upon IN cord-013590-pkm81fq1 118 43 antigen antigen NN cord-013590-pkm81fq1 118 44 exposure exposure NN cord-013590-pkm81fq1 118 45 . . . cord-013590-pkm81fq1 119 1 In in IN cord-013590-pkm81fq1 119 2 fact fact NN cord-013590-pkm81fq1 119 3 , , , cord-013590-pkm81fq1 119 4 the the DT cord-013590-pkm81fq1 119 5 EPCR EPCR NNP cord-013590-pkm81fq1 119 6 - - HYPH cord-013590-pkm81fq1 119 7 reactive reactive JJ cord-013590-pkm81fq1 119 8 LES LES NNP cord-013590-pkm81fq1 119 9 clone clone NN cord-013590-pkm81fq1 119 10 ( ( -LRB- cord-013590-pkm81fq1 119 11 Vγ4Vδ5 vγ4vδ5 NN cord-013590-pkm81fq1 119 12 + + SYM cord-013590-pkm81fq1 119 13 ) ) -RRB- cord-013590-pkm81fq1 119 14 made make VBN cord-013590-pkm81fq1 119 15 up up RP cord-013590-pkm81fq1 119 16 about about RB cord-013590-pkm81fq1 119 17 25 25 CD cord-013590-pkm81fq1 119 18 % % NN cord-013590-pkm81fq1 119 19 of of IN cord-013590-pkm81fq1 119 20 the the DT cord-013590-pkm81fq1 119 21 entire entire JJ cord-013590-pkm81fq1 119 22 T t NN cord-013590-pkm81fq1 119 23 - - HYPH cord-013590-pkm81fq1 119 24 cell cell NN cord-013590-pkm81fq1 119 25 Ligand Ligand NNP cord-013590-pkm81fq1 119 26 recognition recognition NN cord-013590-pkm81fq1 119 27 by by IN cord-013590-pkm81fq1 119 28 the the DT cord-013590-pkm81fq1 119 29 γδ γδ NNP cord-013590-pkm81fq1 119 30 TCR TCR NNP cord-013590-pkm81fq1 119 31 and and CC cord-013590-pkm81fq1 119 32 discrimination discrimination NN cord-013590-pkm81fq1 119 33 between between IN cord-013590-pkm81fq1 119 34 homeostasis homeostasis NN cord-013590-pkm81fq1 119 35 . . . cord-013590-pkm81fq1 119 36 . . . cord-013590-pkm81fq1 119 37 . . . cord-013590-pkm81fq1 120 1 M M NNP cord-013590-pkm81fq1 120 2 Deseke Deseke NNP cord-013590-pkm81fq1 120 3 and and CC cord-013590-pkm81fq1 120 4 I -PRON- PRP cord-013590-pkm81fq1 120 5 Prinz Prinz NNP cord-013590-pkm81fq1 120 6 _SP cord-013590-pkm81fq1 120 7 Peptides peptide NNS cord-013590-pkm81fq1 120 8 of of IN cord-013590-pkm81fq1 120 9 mycobacterial mycobacterial NNP cord-013590-pkm81fq1 120 10 and and CC cord-013590-pkm81fq1 120 11 mammalian mammalian JJ cord-013590-pkm81fq1 120 12 origin origin NN cord-013590-pkm81fq1 120 13 recognized recognize VBD cord-013590-pkm81fq1 120 14 [ [ -LRB- cord-013590-pkm81fq1 120 15 66 66 CD cord-013590-pkm81fq1 120 16 ] ] -RRB- cord-013590-pkm81fq1 121 1 [ [ -LRB- cord-013590-pkm81fq1 121 2 67 67 CD cord-013590-pkm81fq1 121 3 ] ] -RRB- cord-013590-pkm81fq1 122 1 [ [ -LRB- cord-013590-pkm81fq1 122 2 68 68 CD cord-013590-pkm81fq1 122 3 ] ] -RRB- cord-013590-pkm81fq1 123 1 Ligand ligand NN cord-013590-pkm81fq1 123 2 recognition recognition NN cord-013590-pkm81fq1 123 3 by by IN cord-013590-pkm81fq1 123 4 the the DT cord-013590-pkm81fq1 123 5 γδ γδ NNP cord-013590-pkm81fq1 123 6 TCR TCR NNP cord-013590-pkm81fq1 123 7 and and CC cord-013590-pkm81fq1 123 8 discrimination discrimination NN cord-013590-pkm81fq1 123 9 between between IN cord-013590-pkm81fq1 123 10 homeostasis homeostasis NN cord-013590-pkm81fq1 123 11 . . . cord-013590-pkm81fq1 123 12 . . . cord-013590-pkm81fq1 123 13 . . . cord-013590-pkm81fq1 124 1 M M NNP cord-013590-pkm81fq1 124 2 Deseke Deseke NNP cord-013590-pkm81fq1 124 3 and and CC cord-013590-pkm81fq1 124 4 I -PRON- PRP cord-013590-pkm81fq1 125 1 Prinz Prinz NNP cord-013590-pkm81fq1 125 2 repertoire repertoire NN cord-013590-pkm81fq1 125 3 in in IN cord-013590-pkm81fq1 125 4 a a DT cord-013590-pkm81fq1 125 5 CMV CMV NNP cord-013590-pkm81fq1 125 6 - - HYPH cord-013590-pkm81fq1 125 7 positive positive JJ cord-013590-pkm81fq1 125 8 transplanted transplant VBN cord-013590-pkm81fq1 125 9 patient patient NN cord-013590-pkm81fq1 125 10 . . . cord-013590-pkm81fq1 126 1 25 25 CD cord-013590-pkm81fq1 127 1 In in IN cord-013590-pkm81fq1 127 2 addition addition NN cord-013590-pkm81fq1 127 3 to to IN cord-013590-pkm81fq1 127 4 the the DT cord-013590-pkm81fq1 127 5 low low JJ cord-013590-pkm81fq1 127 6 abundance abundance NN cord-013590-pkm81fq1 127 7 of of IN cord-013590-pkm81fq1 127 8 naïve naïve JJ cord-013590-pkm81fq1 127 9 γδ γδ NN cord-013590-pkm81fq1 127 10 T t NN cord-013590-pkm81fq1 127 11 cells cell NNS cord-013590-pkm81fq1 127 12 , , , cord-013590-pkm81fq1 127 13 it -PRON- PRP cord-013590-pkm81fq1 127 14 is be VBZ cord-013590-pkm81fq1 127 15 possible possible JJ cord-013590-pkm81fq1 127 16 that that IN cord-013590-pkm81fq1 127 17 other other JJ cord-013590-pkm81fq1 127 18 MHC MHC NNP cord-013590-pkm81fq1 127 19 - - : cord-013590-pkm81fq1 127 20 or or CC cord-013590-pkm81fq1 127 21 MHC MHC NNP cord-013590-pkm81fq1 127 22 - - HYPH cord-013590-pkm81fq1 127 23 like like JJ cord-013590-pkm81fq1 127 24 reactive reactive JJ cord-013590-pkm81fq1 127 25 γδ γδ IN cord-013590-pkm81fq1 127 26 TCRs tcr NNS cord-013590-pkm81fq1 127 27 escaped escape VBD cord-013590-pkm81fq1 127 28 the the DT cord-013590-pkm81fq1 127 29 detection detection NN cord-013590-pkm81fq1 127 30 by by IN cord-013590-pkm81fq1 127 31 tetramer tetramer NN cord-013590-pkm81fq1 127 32 staining staining NN cord-013590-pkm81fq1 127 33 as as IN cord-013590-pkm81fq1 127 34 in in IN cord-013590-pkm81fq1 127 35 the the DT cord-013590-pkm81fq1 127 36 case case NN cord-013590-pkm81fq1 127 37 of of IN cord-013590-pkm81fq1 127 38 CD1-d CD1-d NNP cord-013590-pkm81fq1 127 39 or or CC cord-013590-pkm81fq1 127 40 MR-1 MR-1 NNP cord-013590-pkm81fq1 127 41 because because IN cord-013590-pkm81fq1 127 42 the the DT cord-013590-pkm81fq1 127 43 affinity affinity NN cord-013590-pkm81fq1 127 44 for for IN cord-013590-pkm81fq1 127 45 their -PRON- PRP$ cord-013590-pkm81fq1 127 46 cognate cognate JJ cord-013590-pkm81fq1 127 47 antigen antigen NN cord-013590-pkm81fq1 127 48 was be VBD cord-013590-pkm81fq1 127 49 too too RB cord-013590-pkm81fq1 127 50 low low JJ cord-013590-pkm81fq1 127 51 for for IN cord-013590-pkm81fq1 127 52 flow flow NN cord-013590-pkm81fq1 127 53 cytometry cytometry NN cord-013590-pkm81fq1 127 54 approaches approach NNS cord-013590-pkm81fq1 127 55 . . . cord-013590-pkm81fq1 128 1 Concerning concern VBG cord-013590-pkm81fq1 128 2 the the DT cord-013590-pkm81fq1 128 3 methodology methodology NN cord-013590-pkm81fq1 128 4 employed employ VBN cord-013590-pkm81fq1 128 5 for for IN cord-013590-pkm81fq1 128 6 the the DT cord-013590-pkm81fq1 128 7 identification identification NN cord-013590-pkm81fq1 128 8 of of IN cord-013590-pkm81fq1 128 9 the the DT cord-013590-pkm81fq1 128 10 so so RB cord-013590-pkm81fq1 128 11 far far RB cord-013590-pkm81fq1 128 12 investigated investigate VBN cord-013590-pkm81fq1 128 13 MHC MHC NNP cord-013590-pkm81fq1 128 14 molecules molecule NNS cord-013590-pkm81fq1 128 15 as as IN cord-013590-pkm81fq1 128 16 γδ γδ IN cord-013590-pkm81fq1 128 17 TCR TCR NNP cord-013590-pkm81fq1 128 18 ligands ligand NNS cord-013590-pkm81fq1 128 19 , , , cord-013590-pkm81fq1 128 20 it -PRON- PRP cord-013590-pkm81fq1 128 21 has have VBZ cord-013590-pkm81fq1 128 22 been be VBN cord-013590-pkm81fq1 128 23 criticized criticize VBN cord-013590-pkm81fq1 128 24 that that IN cord-013590-pkm81fq1 128 25 it -PRON- PRP cord-013590-pkm81fq1 128 26 relied rely VBD cord-013590-pkm81fq1 128 27 to to IN cord-013590-pkm81fq1 128 28 a a DT cord-013590-pkm81fq1 128 29 large large JJ cord-013590-pkm81fq1 128 30 extent extent NN cord-013590-pkm81fq1 128 31 on on IN cord-013590-pkm81fq1 128 32 previous previous JJ cord-013590-pkm81fq1 128 33 knowledge knowledge NN cord-013590-pkm81fq1 128 34 and and CC cord-013590-pkm81fq1 128 35 techniques technique NNS cord-013590-pkm81fq1 128 36 from from IN cord-013590-pkm81fq1 128 37 αβ αβ NNP cord-013590-pkm81fq1 128 38 TCRs TCRs NNP cord-013590-pkm81fq1 128 39 and and CC cord-013590-pkm81fq1 128 40 the the DT cord-013590-pkm81fq1 128 41 detection detection NN cord-013590-pkm81fq1 128 42 of of IN cord-013590-pkm81fq1 128 43 MHC MHC NNP cord-013590-pkm81fq1 128 44 or or CC cord-013590-pkm81fq1 128 45 MHC MHC NNP cord-013590-pkm81fq1 128 46 - - HYPH cord-013590-pkm81fq1 128 47 like like JJ cord-013590-pkm81fq1 128 48 molecules molecule NNS cord-013590-pkm81fq1 128 49 as as IN cord-013590-pkm81fq1 128 50 γδ γδ XX cord-013590-pkm81fq1 129 1 TCR TCR NNP cord-013590-pkm81fq1 129 2 ligands ligand NNS cord-013590-pkm81fq1 129 3 might may MD cord-013590-pkm81fq1 129 4 thus thus RB cord-013590-pkm81fq1 129 5 not not RB cord-013590-pkm81fq1 129 6 appear appear VB cord-013590-pkm81fq1 129 7 very very RB cord-013590-pkm81fq1 129 8 surprising surprising JJ cord-013590-pkm81fq1 129 9 . . . cord-013590-pkm81fq1 130 1 Despite despite IN cord-013590-pkm81fq1 130 2 this this DT cord-013590-pkm81fq1 130 3 technical technical JJ cord-013590-pkm81fq1 130 4 bias bias NN cord-013590-pkm81fq1 130 5 in in IN cord-013590-pkm81fq1 130 6 many many JJ cord-013590-pkm81fq1 130 7 studies study NNS cord-013590-pkm81fq1 130 8 published publish VBN cord-013590-pkm81fq1 130 9 in in IN cord-013590-pkm81fq1 130 10 the the DT cord-013590-pkm81fq1 130 11 past past NN cord-013590-pkm81fq1 130 12 , , , cord-013590-pkm81fq1 130 13 the the DT cord-013590-pkm81fq1 130 14 identification identification NN cord-013590-pkm81fq1 130 15 of of IN cord-013590-pkm81fq1 130 16 HLA HLA NNP cord-013590-pkm81fq1 130 17 * * NFP cord-013590-pkm81fq1 130 18 24:02 24:02 CD cord-013590-pkm81fq1 130 19 as as IN cord-013590-pkm81fq1 130 20 an an DT cord-013590-pkm81fq1 130 21 antigen antigen NN cord-013590-pkm81fq1 130 22 for for IN cord-013590-pkm81fq1 130 23 the the DT cord-013590-pkm81fq1 130 24 alloreactive alloreactive NN cord-013590-pkm81fq1 130 25 Vγ5Vδ1 Vγ5Vδ1 . cord-013590-pkm81fq1 131 1 + + CC cord-013590-pkm81fq1 132 1 γδ γδ CC cord-013590-pkm81fq1 132 2 TCR TCR NNP cord-013590-pkm81fq1 132 3 by by IN cord-013590-pkm81fq1 132 4 Kierkels Kierkels NNP cord-013590-pkm81fq1 132 5 et et NNP cord-013590-pkm81fq1 132 6 al al NNP cord-013590-pkm81fq1 132 7 . . NNP cord-013590-pkm81fq1 132 8 indicates indicate VBZ cord-013590-pkm81fq1 132 9 that that IN cord-013590-pkm81fq1 132 10 also also RB cord-013590-pkm81fq1 132 11 approaches approach VBZ cord-013590-pkm81fq1 132 12 without without IN cord-013590-pkm81fq1 132 13 preconceived preconceived JJ cord-013590-pkm81fq1 132 14 ideas idea NNS cord-013590-pkm81fq1 132 15 of of IN cord-013590-pkm81fq1 132 16 putative putative JJ cord-013590-pkm81fq1 132 17 antigen antigen NN cord-013590-pkm81fq1 132 18 candidates candidate NNS cord-013590-pkm81fq1 132 19 can can MD cord-013590-pkm81fq1 132 20 reveal reveal VB cord-013590-pkm81fq1 132 21 MHC MHC NNP cord-013590-pkm81fq1 132 22 or or CC cord-013590-pkm81fq1 132 23 MHC MHC NNP cord-013590-pkm81fq1 132 24 - - HYPH cord-013590-pkm81fq1 132 25 like like JJ cord-013590-pkm81fq1 132 26 molecules molecule NNS cord-013590-pkm81fq1 132 27 as as IN cord-013590-pkm81fq1 132 28 γδ γδ NNP cord-013590-pkm81fq1 132 29 TCR TCR NNP cord-013590-pkm81fq1 132 30 ligands ligand NNS cord-013590-pkm81fq1 132 31 . . . cord-013590-pkm81fq1 133 1 23 23 CD cord-013590-pkm81fq1 134 1 The the DT cord-013590-pkm81fq1 134 2 question question NN cord-013590-pkm81fq1 134 3 to to IN cord-013590-pkm81fq1 134 4 what what WDT cord-013590-pkm81fq1 134 5 extent extent NN cord-013590-pkm81fq1 134 6 the the DT cord-013590-pkm81fq1 134 7 reactivity reactivity NN cord-013590-pkm81fq1 134 8 to to IN cord-013590-pkm81fq1 134 9 MHC MHC NNP cord-013590-pkm81fq1 134 10 molecules molecule NNS cord-013590-pkm81fq1 134 11 can can MD cord-013590-pkm81fq1 134 12 be be VB cord-013590-pkm81fq1 134 13 generalized generalize VBN cord-013590-pkm81fq1 134 14 awaits await NNS cord-013590-pkm81fq1 135 1 further further JJ cord-013590-pkm81fq1 135 2 investigation investigation NN cord-013590-pkm81fq1 135 3 and and CC cord-013590-pkm81fq1 135 4 unbiased unbiased JJ cord-013590-pkm81fq1 135 5 identification identification NN cord-013590-pkm81fq1 135 6 of of IN cord-013590-pkm81fq1 135 7 reactive reactive JJ cord-013590-pkm81fq1 135 8 γδ γδ IN cord-013590-pkm81fq1 135 9 TCRs tcr NNS cord-013590-pkm81fq1 135 10 . . . cord-013590-pkm81fq1 136 1 Adaptive adaptive JJ cord-013590-pkm81fq1 136 2 or or CC cord-013590-pkm81fq1 136 3 adaptive adaptive JJ cord-013590-pkm81fq1 136 4 like like IN cord-013590-pkm81fq1 136 5 antigen antigen NN cord-013590-pkm81fq1 136 6 recognition recognition NN cord-013590-pkm81fq1 136 7 by by IN cord-013590-pkm81fq1 136 8 γδ γδ IN cord-013590-pkm81fq1 136 9 TCRs TCRs NNP cord-013590-pkm81fq1 136 10 is be VBZ cord-013590-pkm81fq1 136 11 by by IN cord-013590-pkm81fq1 136 12 no no DT cord-013590-pkm81fq1 136 13 means mean NNS cord-013590-pkm81fq1 136 14 limited limited JJ cord-013590-pkm81fq1 136 15 to to IN cord-013590-pkm81fq1 136 16 MHC MHC NNP cord-013590-pkm81fq1 136 17 - - : cord-013590-pkm81fq1 136 18 or or CC cord-013590-pkm81fq1 136 19 MHC MHC NNP cord-013590-pkm81fq1 136 20 - - HYPH cord-013590-pkm81fq1 136 21 like like JJ cord-013590-pkm81fq1 136 22 molecules molecule NNS cord-013590-pkm81fq1 136 23 as as IN cord-013590-pkm81fq1 136 24 shows show VBZ cord-013590-pkm81fq1 136 25 the the DT cord-013590-pkm81fq1 136 26 wide wide JJ cord-013590-pkm81fq1 136 27 and and CC cord-013590-pkm81fq1 136 28 diverse diverse JJ cord-013590-pkm81fq1 136 29 range range NN cord-013590-pkm81fq1 136 30 of of IN cord-013590-pkm81fq1 136 31 cell cell NN cord-013590-pkm81fq1 136 32 surface surface NN cord-013590-pkm81fq1 136 33 or or CC cord-013590-pkm81fq1 136 34 soluble soluble JJ cord-013590-pkm81fq1 136 35 molecules molecule NNS cord-013590-pkm81fq1 136 36 reported report VBN cord-013590-pkm81fq1 136 37 to to TO cord-013590-pkm81fq1 136 38 be be VB cord-013590-pkm81fq1 136 39 γδ γδ IN cord-013590-pkm81fq1 136 40 TCR TCR NNP cord-013590-pkm81fq1 136 41 antigens antigen NNS cord-013590-pkm81fq1 136 42 . . . cord-013590-pkm81fq1 137 1 These these DT cord-013590-pkm81fq1 137 2 include include VBP cord-013590-pkm81fq1 137 3 the the DT cord-013590-pkm81fq1 137 4 cell cell NN cord-013590-pkm81fq1 137 5 stress stress NN cord-013590-pkm81fq1 137 6 - - HYPH cord-013590-pkm81fq1 137 7 induced induce VBN cord-013590-pkm81fq1 137 8 Annexin Annexin NNP cord-013590-pkm81fq1 137 9 A2 A2 NNP cord-013590-pkm81fq1 137 10 53 53 CD cord-013590-pkm81fq1 137 11 and and CC cord-013590-pkm81fq1 137 12 ephrin ephrin NNP cord-013590-pkm81fq1 137 13 receptor receptor NNP cord-013590-pkm81fq1 137 14 A2 A2 NNP cord-013590-pkm81fq1 137 15 ( ( -LRB- cord-013590-pkm81fq1 137 16 EphA2 EphA2 NNP cord-013590-pkm81fq1 137 17 ) ) -RRB- cord-013590-pkm81fq1 137 18 , , , cord-013590-pkm81fq1 137 19 54 54 CD cord-013590-pkm81fq1 137 20 which which WDT cord-013590-pkm81fq1 137 21 were be VBD cord-013590-pkm81fq1 137 22 recognized recognize VBN cord-013590-pkm81fq1 137 23 by by IN cord-013590-pkm81fq1 137 24 Vδ2 Vδ2 NNP cord-013590-pkm81fq1 137 25 − − NNP cord-013590-pkm81fq1 137 26 γδ γδ CC cord-013590-pkm81fq1 137 27 T t NN cord-013590-pkm81fq1 137 28 - - HYPH cord-013590-pkm81fq1 137 29 cell cell NN cord-013590-pkm81fq1 137 30 clones clone NNS cord-013590-pkm81fq1 137 31 in in IN cord-013590-pkm81fq1 137 32 a a DT cord-013590-pkm81fq1 137 33 TCR TCR NNP cord-013590-pkm81fq1 137 34 - - HYPH cord-013590-pkm81fq1 137 35 dependent dependent JJ cord-013590-pkm81fq1 137 36 manner manner NN cord-013590-pkm81fq1 137 37 on on IN cord-013590-pkm81fq1 137 38 cells cell NNS cord-013590-pkm81fq1 137 39 that that WDT cord-013590-pkm81fq1 137 40 were be VBD cord-013590-pkm81fq1 137 41 either either CC cord-013590-pkm81fq1 137 42 transformed transform VBN cord-013590-pkm81fq1 137 43 , , , cord-013590-pkm81fq1 137 44 CMV CMV NNP cord-013590-pkm81fq1 137 45 - - HYPH cord-013590-pkm81fq1 137 46 infected infect VBN cord-013590-pkm81fq1 137 47 or or CC cord-013590-pkm81fq1 137 48 exposed expose VBN cord-013590-pkm81fq1 137 49 to to IN cord-013590-pkm81fq1 137 50 abiotic abiotic JJ cord-013590-pkm81fq1 137 51 stressors stressor NNS cord-013590-pkm81fq1 137 52 , , , cord-013590-pkm81fq1 137 53 e.g. e.g. RB cord-013590-pkm81fq1 137 54 , , , cord-013590-pkm81fq1 137 55 heat heat NN cord-013590-pkm81fq1 137 56 . . . cord-013590-pkm81fq1 138 1 The the DT cord-013590-pkm81fq1 138 2 human human JJ cord-013590-pkm81fq1 138 3 DNA dna NN cord-013590-pkm81fq1 138 4 mismatch mismatch NN cord-013590-pkm81fq1 138 5 repair repair NN cord-013590-pkm81fq1 138 6 protein protein NN cord-013590-pkm81fq1 138 7 MutS MutS NNP cord-013590-pkm81fq1 138 8 - - HYPH cord-013590-pkm81fq1 138 9 Homologue Homologue NNP cord-013590-pkm81fq1 138 10 2 2 CD cord-013590-pkm81fq1 139 1 ( ( -LRB- cord-013590-pkm81fq1 139 2 hMSH2 hmsh2 NN cord-013590-pkm81fq1 139 3 ) ) -RRB- cord-013590-pkm81fq1 139 4 55 55 CD cord-013590-pkm81fq1 139 5 is be VBZ cord-013590-pkm81fq1 139 6 found find VBN cord-013590-pkm81fq1 139 7 at at IN cord-013590-pkm81fq1 139 8 the the DT cord-013590-pkm81fq1 139 9 cell cell NN cord-013590-pkm81fq1 139 10 surface surface NN cord-013590-pkm81fq1 139 11 of of IN cord-013590-pkm81fq1 139 12 malignant malignant JJ cord-013590-pkm81fq1 139 13 cells cell NNS cord-013590-pkm81fq1 139 14 and and CC cord-013590-pkm81fq1 139 15 induces induce VBZ cord-013590-pkm81fq1 139 16 target target NN cord-013590-pkm81fq1 139 17 cell cell NN cord-013590-pkm81fq1 139 18 killing kill VBG cord-013590-pkm81fq1 139 19 dependent dependent JJ cord-013590-pkm81fq1 139 20 on on IN cord-013590-pkm81fq1 139 21 Vδ2 vδ2 NN cord-013590-pkm81fq1 139 22 + + . cord-013590-pkm81fq1 140 1 γδ γδ CC cord-013590-pkm81fq1 140 2 TCRs TCRs NNP cord-013590-pkm81fq1 140 3 . . . cord-013590-pkm81fq1 141 1 Furthermore furthermore RB cord-013590-pkm81fq1 141 2 , , , cord-013590-pkm81fq1 141 3 histidyl histidyl NNP cord-013590-pkm81fq1 141 4 tRNA tRNA NNP cord-013590-pkm81fq1 141 5 synthetase synthetase NNP cord-013590-pkm81fq1 141 6 56,57 56,57 CD cord-013590-pkm81fq1 141 7 is be VBZ cord-013590-pkm81fq1 141 8 recognized recognize VBN cord-013590-pkm81fq1 141 9 by by IN cord-013590-pkm81fq1 141 10 a a DT cord-013590-pkm81fq1 141 11 Vγ3Vδ2 Vγ3Vδ2 NNS cord-013590-pkm81fq1 142 1 + + CC cord-013590-pkm81fq1 142 2 TCR TCR NNP cord-013590-pkm81fq1 142 3 identified identify VBD cord-013590-pkm81fq1 142 4 in in IN cord-013590-pkm81fq1 142 5 a a DT cord-013590-pkm81fq1 142 6 polymyositis polymyositis NN cord-013590-pkm81fq1 142 7 patient patient NN cord-013590-pkm81fq1 142 8 although although IN cord-013590-pkm81fq1 142 9 it -PRON- PRP cord-013590-pkm81fq1 142 10 remains remain VBZ cord-013590-pkm81fq1 142 11 elusive elusive JJ cord-013590-pkm81fq1 142 12 how how WRB cord-013590-pkm81fq1 142 13 this this DT cord-013590-pkm81fq1 142 14 target target NN cord-013590-pkm81fq1 142 15 can can MD cord-013590-pkm81fq1 142 16 be be VB cord-013590-pkm81fq1 142 17 reached reach VBN cord-013590-pkm81fq1 142 18 by by IN cord-013590-pkm81fq1 142 19 the the DT cord-013590-pkm81fq1 142 20 γδ γδ NN cord-013590-pkm81fq1 142 21 TCR TCR NNP cord-013590-pkm81fq1 142 22 since since IN cord-013590-pkm81fq1 142 23 no no DT cord-013590-pkm81fq1 142 24 cell cell NN cord-013590-pkm81fq1 142 25 - - HYPH cord-013590-pkm81fq1 142 26 surface surface NN cord-013590-pkm81fq1 142 27 exposition exposition NN cord-013590-pkm81fq1 142 28 has have VBZ cord-013590-pkm81fq1 142 29 been be VBN cord-013590-pkm81fq1 142 30 shown show VBN cord-013590-pkm81fq1 142 31 to to IN cord-013590-pkm81fq1 142 32 date date NN cord-013590-pkm81fq1 142 33 . . . cord-013590-pkm81fq1 143 1 In in IN cord-013590-pkm81fq1 143 2 both both DT cord-013590-pkm81fq1 143 3 cases case NNS cord-013590-pkm81fq1 143 4 the the DT cord-013590-pkm81fq1 143 5 γδ γδ IN cord-013590-pkm81fq1 143 6 TCRs tcr NNS cord-013590-pkm81fq1 143 7 were be VBD cord-013590-pkm81fq1 143 8 Vγ9 Vγ9 NNS cord-013590-pkm81fq1 143 9 − − NNP cord-013590-pkm81fq1 143 10 Vδ2 Vδ2 NNP cord-013590-pkm81fq1 144 1 + + UH cord-013590-pkm81fq1 144 2 . . . cord-013590-pkm81fq1 145 1 Foreign foreign JJ cord-013590-pkm81fq1 145 2 antigens antigen NNS cord-013590-pkm81fq1 145 3 derived derive VBN cord-013590-pkm81fq1 145 4 from from IN cord-013590-pkm81fq1 145 5 pathogenic pathogenic JJ cord-013590-pkm81fq1 145 6 or or CC cord-013590-pkm81fq1 145 7 nonpathogenic nonpathogenic JJ cord-013590-pkm81fq1 145 8 organisms organism NNS cord-013590-pkm81fq1 145 9 that that WDT cord-013590-pkm81fq1 145 10 have have VBP cord-013590-pkm81fq1 145 11 been be VBN cord-013590-pkm81fq1 145 12 reported report VBN cord-013590-pkm81fq1 145 13 to to TO cord-013590-pkm81fq1 145 14 activate activate VB cord-013590-pkm81fq1 145 15 γδ γδ IN cord-013590-pkm81fq1 145 16 TCRs tcr NNS cord-013590-pkm81fq1 145 17 comprise comprise VBP cord-013590-pkm81fq1 145 18 herpex herpex NNP cord-013590-pkm81fq1 145 19 simplex simplex NNP cord-013590-pkm81fq1 145 20 virus virus NN cord-013590-pkm81fq1 145 21 glycoprotein glycoprotein NN cord-013590-pkm81fq1 145 22 I i NN cord-013590-pkm81fq1 145 23 ( ( -LRB- cord-013590-pkm81fq1 145 24 HSV HSV NNP cord-013590-pkm81fq1 145 25 - - HYPH cord-013590-pkm81fq1 145 26 gI gI NNP cord-013590-pkm81fq1 145 27 ) ) -RRB- cord-013590-pkm81fq1 145 28 recognized recognize VBN cord-013590-pkm81fq1 145 29 by by IN cord-013590-pkm81fq1 145 30 a a DT cord-013590-pkm81fq1 145 31 murine murine NN cord-013590-pkm81fq1 145 32 Vγ2Vδ8 Vγ2Vδ8 NNS cord-013590-pkm81fq1 145 33 + + CC cord-013590-pkm81fq1 145 34 TCR TCR NNP cord-013590-pkm81fq1 145 35 , , , cord-013590-pkm81fq1 145 36 58 58 CD cord-013590-pkm81fq1 145 37 bacterial bacterial JJ cord-013590-pkm81fq1 145 38 superantigens superantigen NNS cord-013590-pkm81fq1 145 39 such such JJ cord-013590-pkm81fq1 145 40 as as IN cord-013590-pkm81fq1 145 41 SEA SEA NNP cord-013590-pkm81fq1 145 42 , , , cord-013590-pkm81fq1 145 43 OXYS OXYS NNP cord-013590-pkm81fq1 145 44 , , , cord-013590-pkm81fq1 145 45 and and CC cord-013590-pkm81fq1 145 46 DX2 DX2 NNP cord-013590-pkm81fq1 145 47 59 59 CD cord-013590-pkm81fq1 145 48 - - SYM cord-013590-pkm81fq1 145 49 61 61 CD cord-013590-pkm81fq1 145 50 and and CC cord-013590-pkm81fq1 145 51 even even RB cord-013590-pkm81fq1 145 52 the the DT cord-013590-pkm81fq1 145 53 algal algal JJ cord-013590-pkm81fq1 145 54 protein protein NN cord-013590-pkm81fq1 145 55 phycoerythrin phycoerythrin FW cord-013590-pkm81fq1 145 56 ( ( -LRB- cord-013590-pkm81fq1 145 57 PE PE NNP cord-013590-pkm81fq1 145 58 ) ) -RRB- cord-013590-pkm81fq1 145 59 , , , cord-013590-pkm81fq1 145 60 which which WDT cord-013590-pkm81fq1 145 61 is be VBZ cord-013590-pkm81fq1 145 62 a a DT cord-013590-pkm81fq1 145 63 prototype prototype NN cord-013590-pkm81fq1 145 64 B b NN cord-013590-pkm81fq1 145 65 - - HYPH cord-013590-pkm81fq1 145 66 cell cell NN cord-013590-pkm81fq1 145 67 antigen antigen NN cord-013590-pkm81fq1 145 68 but but CC cord-013590-pkm81fq1 145 69 can can MD cord-013590-pkm81fq1 145 70 also also RB cord-013590-pkm81fq1 145 71 be be VB cord-013590-pkm81fq1 145 72 bound bind VBN cord-013590-pkm81fq1 145 73 by by IN cord-013590-pkm81fq1 145 74 range range NN cord-013590-pkm81fq1 145 75 of of IN cord-013590-pkm81fq1 145 76 different different JJ cord-013590-pkm81fq1 145 77 murine murine NN cord-013590-pkm81fq1 145 78 , , , cord-013590-pkm81fq1 145 79 ruminant ruminant NN cord-013590-pkm81fq1 145 80 as as RB cord-013590-pkm81fq1 145 81 well well RB cord-013590-pkm81fq1 145 82 as as IN cord-013590-pkm81fq1 145 83 human human NN cord-013590-pkm81fq1 145 84 γδ γδ IN cord-013590-pkm81fq1 145 85 TCRs tcr NNS cord-013590-pkm81fq1 145 86 . . . cord-013590-pkm81fq1 146 1 62 62 CD cord-013590-pkm81fq1 147 1 Similar similar JJ cord-013590-pkm81fq1 147 2 observations observation NNS cord-013590-pkm81fq1 147 3 were be VBD cord-013590-pkm81fq1 147 4 made make VBN cord-013590-pkm81fq1 147 5 with with IN cord-013590-pkm81fq1 147 6 the the DT cord-013590-pkm81fq1 147 7 haptens hapten NNS cord-013590-pkm81fq1 147 8 Cy3 cy3 NN cord-013590-pkm81fq1 147 9 and and CC cord-013590-pkm81fq1 147 10 NP NP NNP cord-013590-pkm81fq1 147 11 . . . cord-013590-pkm81fq1 148 1 63 63 CD cord-013590-pkm81fq1 149 1 However however RB cord-013590-pkm81fq1 149 2 , , , cord-013590-pkm81fq1 149 3 it -PRON- PRP cord-013590-pkm81fq1 149 4 is be VBZ cord-013590-pkm81fq1 149 5 very very RB cord-013590-pkm81fq1 149 6 unlikely unlikely JJ cord-013590-pkm81fq1 149 7 that that IN cord-013590-pkm81fq1 149 8 PE PE NNP cord-013590-pkm81fq1 149 9 or or CC cord-013590-pkm81fq1 149 10 haptens hapten NNS cord-013590-pkm81fq1 149 11 represent represent VBP cord-013590-pkm81fq1 149 12 actual actual JJ cord-013590-pkm81fq1 149 13 antigens antigen NNS cord-013590-pkm81fq1 149 14 under under IN cord-013590-pkm81fq1 149 15 physiological physiological JJ cord-013590-pkm81fq1 149 16 conditions condition NNS cord-013590-pkm81fq1 149 17 . . . cord-013590-pkm81fq1 150 1 Nevertheless nevertheless RB cord-013590-pkm81fq1 150 2 , , , cord-013590-pkm81fq1 150 3 these these DT cord-013590-pkm81fq1 150 4 studies study NNS cord-013590-pkm81fq1 150 5 underline underline VBP cord-013590-pkm81fq1 150 6 the the DT cord-013590-pkm81fq1 150 7 plasticity plasticity NN cord-013590-pkm81fq1 150 8 of of IN cord-013590-pkm81fq1 150 9 γδ γδ NN cord-013590-pkm81fq1 151 1 TCR TCR NNP cord-013590-pkm81fq1 151 2 target target NN cord-013590-pkm81fq1 151 3 recognition recognition NN cord-013590-pkm81fq1 151 4 and and CC cord-013590-pkm81fq1 151 5 it -PRON- PRP cord-013590-pkm81fq1 151 6 might may MD cord-013590-pkm81fq1 151 7 be be VB cord-013590-pkm81fq1 151 8 used use VBN cord-013590-pkm81fq1 151 9 in in IN cord-013590-pkm81fq1 151 10 experimental experimental JJ cord-013590-pkm81fq1 151 11 models model NNS cord-013590-pkm81fq1 151 12 . . . cord-013590-pkm81fq1 152 1 Strikingly strikingly RB cord-013590-pkm81fq1 152 2 , , , cord-013590-pkm81fq1 152 3 not not RB cord-013590-pkm81fq1 152 4 only only RB cord-013590-pkm81fq1 152 5 entire entire JJ cord-013590-pkm81fq1 152 6 proteins protein NNS cord-013590-pkm81fq1 152 7 but but CC cord-013590-pkm81fq1 152 8 also also RB cord-013590-pkm81fq1 153 1 small small JJ cord-013590-pkm81fq1 153 2 peptide peptide NN cord-013590-pkm81fq1 153 3 fragments fragment NNS cord-013590-pkm81fq1 153 4 can can MD cord-013590-pkm81fq1 153 5 be be VB cord-013590-pkm81fq1 153 6 detected detect VBN cord-013590-pkm81fq1 153 7 by by IN cord-013590-pkm81fq1 153 8 γδ γδ NNP cord-013590-pkm81fq1 153 9 TCR TCR NNP cord-013590-pkm81fq1 153 10 without without IN cord-013590-pkm81fq1 153 11 the the DT cord-013590-pkm81fq1 153 12 requirement requirement NN cord-013590-pkm81fq1 153 13 for for IN cord-013590-pkm81fq1 153 14 presentation presentation NN cord-013590-pkm81fq1 153 15 by by IN cord-013590-pkm81fq1 153 16 other other JJ cord-013590-pkm81fq1 153 17 cells cell NNS cord-013590-pkm81fq1 153 18 or or CC cord-013590-pkm81fq1 153 19 molecules molecule NNS cord-013590-pkm81fq1 153 20 . . . cord-013590-pkm81fq1 154 1 Examples example NNS cord-013590-pkm81fq1 154 2 are be VBP cord-013590-pkm81fq1 154 3 the the DT cord-013590-pkm81fq1 154 4 insulin insulin NN cord-013590-pkm81fq1 154 5 peptide peptide NN cord-013590-pkm81fq1 154 6 B:9 B:9 NNP cord-013590-pkm81fq1 154 7 - - HYPH cord-013590-pkm81fq1 154 8 23 23 CD cord-013590-pkm81fq1 154 9 in in IN cord-013590-pkm81fq1 154 10 mice mouse NNS cord-013590-pkm81fq1 154 11 , , , cord-013590-pkm81fq1 154 12 64 64 CD cord-013590-pkm81fq1 154 13 , , , cord-013590-pkm81fq1 154 14 65 65 CD cord-013590-pkm81fq1 154 15 peptides peptide NNS cord-013590-pkm81fq1 154 16 derived derive VBN cord-013590-pkm81fq1 154 17 from from IN cord-013590-pkm81fq1 154 18 mycobacterial mycobacterial NNP cord-013590-pkm81fq1 154 19 and and CC cord-013590-pkm81fq1 154 20 mammalian mammalian JJ cord-013590-pkm81fq1 154 21 heat heat NN cord-013590-pkm81fq1 154 22 shock shock NN cord-013590-pkm81fq1 154 23 proteins protein NNS cord-013590-pkm81fq1 154 24 in in IN cord-013590-pkm81fq1 154 25 mice mouse NNS cord-013590-pkm81fq1 154 26 and and CC cord-013590-pkm81fq1 154 27 humans human NNS cord-013590-pkm81fq1 154 28 [ [ -LRB- cord-013590-pkm81fq1 154 29 66 66 CD cord-013590-pkm81fq1 154 30 ] ] -RRB- cord-013590-pkm81fq1 155 1 [ [ -LRB- cord-013590-pkm81fq1 155 2 67 67 CD cord-013590-pkm81fq1 155 3 ] ] -RRB- cord-013590-pkm81fq1 156 1 [ [ -LRB- cord-013590-pkm81fq1 156 2 68 68 CD cord-013590-pkm81fq1 156 3 ] ] -RRB- cord-013590-pkm81fq1 156 4 and and CC cord-013590-pkm81fq1 156 5 from from IN cord-013590-pkm81fq1 156 6 the the DT cord-013590-pkm81fq1 156 7 Lysteria Lysteria NNP cord-013590-pkm81fq1 156 8 monocytogenes monocytogenes NN cord-013590-pkm81fq1 156 9 protein protein NN cord-013590-pkm81fq1 156 10 Listeriolysin Listeriolysin NNP cord-013590-pkm81fq1 156 11 O o UH cord-013590-pkm81fq1 156 12 in in IN cord-013590-pkm81fq1 156 13 humans human NNS cord-013590-pkm81fq1 156 14 . . . cord-013590-pkm81fq1 157 1 69 69 CD cord-013590-pkm81fq1 157 2 Other other JJ cord-013590-pkm81fq1 157 3 peptides peptide NNS cord-013590-pkm81fq1 157 4 , , , cord-013590-pkm81fq1 157 5 however however RB cord-013590-pkm81fq1 157 6 , , , cord-013590-pkm81fq1 157 7 do do VBP cord-013590-pkm81fq1 157 8 not not RB cord-013590-pkm81fq1 157 9 bind bind VB cord-013590-pkm81fq1 157 10 the the DT cord-013590-pkm81fq1 157 11 TCR TCR NNP cord-013590-pkm81fq1 157 12 directly directly RB cord-013590-pkm81fq1 157 13 but but CC cord-013590-pkm81fq1 157 14 seem seem VBP cord-013590-pkm81fq1 157 15 to to TO cord-013590-pkm81fq1 157 16 require require VB cord-013590-pkm81fq1 157 17 presentation presentation NN cord-013590-pkm81fq1 157 18 on on IN cord-013590-pkm81fq1 157 19 target target NN cord-013590-pkm81fq1 157 20 cells cell NNS cord-013590-pkm81fq1 157 21 such such JJ cord-013590-pkm81fq1 157 22 as as IN cord-013590-pkm81fq1 157 23 those those DT cord-013590-pkm81fq1 157 24 derived derive VBN cord-013590-pkm81fq1 157 25 from from IN cord-013590-pkm81fq1 157 26 tetanus tetanus JJ cord-013590-pkm81fq1 157 27 toxin toxin NN cord-013590-pkm81fq1 157 28 70 70 CD cord-013590-pkm81fq1 157 29 , , , cord-013590-pkm81fq1 157 30 71 71 CD cord-013590-pkm81fq1 157 31 and and CC cord-013590-pkm81fq1 157 32 from from IN cord-013590-pkm81fq1 157 33 immunoglobulin immunoglobulin NN cord-013590-pkm81fq1 157 34 λ λ NN cord-013590-pkm81fq1 157 35 - - HYPH cord-013590-pkm81fq1 157 36 chain chain NN cord-013590-pkm81fq1 157 37 from from IN cord-013590-pkm81fq1 157 38 B b NN cord-013590-pkm81fq1 157 39 - - HYPH cord-013590-pkm81fq1 157 40 cell cell NN cord-013590-pkm81fq1 157 41 lymphoma lymphoma NN cord-013590-pkm81fq1 157 42 . . . cord-013590-pkm81fq1 158 1 72 72 CD cord-013590-pkm81fq1 158 2 , , , cord-013590-pkm81fq1 158 3 73 73 CD cord-013590-pkm81fq1 158 4 Recognition recognition NN cord-013590-pkm81fq1 158 5 of of IN cord-013590-pkm81fq1 158 6 these these DT cord-013590-pkm81fq1 158 7 peptides peptide NNS cord-013590-pkm81fq1 158 8 , , , cord-013590-pkm81fq1 158 9 whether whether IN cord-013590-pkm81fq1 158 10 presented present VBN cord-013590-pkm81fq1 158 11 or or CC cord-013590-pkm81fq1 158 12 not not RB cord-013590-pkm81fq1 158 13 , , , cord-013590-pkm81fq1 158 14 was be VBD cord-013590-pkm81fq1 158 15 found find VBN cord-013590-pkm81fq1 158 16 to to TO cord-013590-pkm81fq1 158 17 be be VB cord-013590-pkm81fq1 158 18 γδ γδ XX cord-013590-pkm81fq1 159 1 TCR TCR NNP cord-013590-pkm81fq1 159 2 dependent dependent JJ cord-013590-pkm81fq1 160 1 but but CC cord-013590-pkm81fq1 160 2 neither neither DT cord-013590-pkm81fq1 160 3 were be VBD cord-013590-pkm81fq1 160 4 direct direct JJ cord-013590-pkm81fq1 160 5 interactions interaction NNS cord-013590-pkm81fq1 160 6 between between IN cord-013590-pkm81fq1 160 7 γδ γδ IN cord-013590-pkm81fq1 160 8 TCR TCR NNP cord-013590-pkm81fq1 160 9 and and CC cord-013590-pkm81fq1 160 10 peptides peptide NNS cord-013590-pkm81fq1 160 11 shown show VBN cord-013590-pkm81fq1 160 12 nor nor CC cord-013590-pkm81fq1 160 13 exists exist VBZ cord-013590-pkm81fq1 160 14 evidence evidence NN cord-013590-pkm81fq1 160 15 for for IN cord-013590-pkm81fq1 160 16 their -PRON- PRP$ cord-013590-pkm81fq1 160 17 physiological physiological JJ cord-013590-pkm81fq1 160 18 relevance relevance NN cord-013590-pkm81fq1 160 19 . . . cord-013590-pkm81fq1 161 1 Recently recently RB cord-013590-pkm81fq1 161 2 , , , cord-013590-pkm81fq1 161 3 murine murine JJ cord-013590-pkm81fq1 161 4 γδ γδ IN cord-013590-pkm81fq1 161 5 NKT NKT NNP cord-013590-pkm81fq1 161 6 cells cell NNS cord-013590-pkm81fq1 161 7 with with IN cord-013590-pkm81fq1 162 1 a a DT cord-013590-pkm81fq1 162 2 Vγ1Vδ6.3 Vγ1Vδ6.3 NNP cord-013590-pkm81fq1 162 3 + + CC cord-013590-pkm81fq1 162 4 TCR TCR NNP cord-013590-pkm81fq1 162 5 were be VBD cord-013590-pkm81fq1 162 6 found find VBN cord-013590-pkm81fq1 162 7 to to TO cord-013590-pkm81fq1 162 8 be be VB cord-013590-pkm81fq1 162 9 activated activate VBN cord-013590-pkm81fq1 162 10 constitutively constitutively RB cord-013590-pkm81fq1 162 11 when when WRB cord-013590-pkm81fq1 162 12 cultured culture VBN cord-013590-pkm81fq1 162 13 in in IN cord-013590-pkm81fq1 162 14 vitro vitro FW cord-013590-pkm81fq1 162 15 . . . cord-013590-pkm81fq1 163 1 The the DT cord-013590-pkm81fq1 163 2 reaction reaction NN cord-013590-pkm81fq1 163 3 was be VBD cord-013590-pkm81fq1 163 4 TCR TCR NNP cord-013590-pkm81fq1 163 5 - - HYPH cord-013590-pkm81fq1 163 6 dependent dependent JJ cord-013590-pkm81fq1 163 7 and and CC cord-013590-pkm81fq1 163 8 driven drive VBN cord-013590-pkm81fq1 163 9 by by IN cord-013590-pkm81fq1 163 10 polyanions polyanion NNS cord-013590-pkm81fq1 163 11 present present JJ cord-013590-pkm81fq1 163 12 on on IN cord-013590-pkm81fq1 163 13 the the DT cord-013590-pkm81fq1 163 14 treated treat VBN cord-013590-pkm81fq1 163 15 plastic plastic NN cord-013590-pkm81fq1 163 16 ware ware NN cord-013590-pkm81fq1 163 17 used use VBN cord-013590-pkm81fq1 163 18 for for IN cord-013590-pkm81fq1 163 19 culturing culture VBG cord-013590-pkm81fq1 163 20 the the DT cord-013590-pkm81fq1 163 21 cells cell NNS cord-013590-pkm81fq1 163 22 . . . cord-013590-pkm81fq1 164 1 74 74 CD cord-013590-pkm81fq1 165 1 Although although IN cord-013590-pkm81fq1 165 2 both both DT cord-013590-pkm81fq1 165 3 chains chain NNS cord-013590-pkm81fq1 165 4 were be VBD cord-013590-pkm81fq1 165 5 required require VBN cord-013590-pkm81fq1 165 6 for for IN cord-013590-pkm81fq1 165 7 the the DT cord-013590-pkm81fq1 165 8 reactivity reactivity NN cord-013590-pkm81fq1 165 9 , , , cord-013590-pkm81fq1 165 10 the the DT cord-013590-pkm81fq1 165 11 Vγ1-chain Vγ1-chain NNP cord-013590-pkm81fq1 165 12 seemed seem VBD cord-013590-pkm81fq1 165 13 to to TO cord-013590-pkm81fq1 165 14 have have VB cord-013590-pkm81fq1 165 15 a a DT cord-013590-pkm81fq1 165 16 slightly slightly RB cord-013590-pkm81fq1 165 17 higher high JJR cord-013590-pkm81fq1 165 18 importance importance NN cord-013590-pkm81fq1 165 19 with with IN cord-013590-pkm81fq1 165 20 only only JJ cord-013590-pkm81fq1 165 21 secondary secondary JJ cord-013590-pkm81fq1 165 22 relevance relevance NN cord-013590-pkm81fq1 165 23 of of IN cord-013590-pkm81fq1 165 24 the the DT cord-013590-pkm81fq1 165 25 CDR3 CDR3 NNP cord-013590-pkm81fq1 165 26 . . . cord-013590-pkm81fq1 166 1 Interestingly interestingly RB cord-013590-pkm81fq1 166 2 , , , cord-013590-pkm81fq1 166 3 many many JJ cord-013590-pkm81fq1 166 4 of of IN cord-013590-pkm81fq1 166 5 the the DT cord-013590-pkm81fq1 166 6 aforementioned aforementioned JJ cord-013590-pkm81fq1 166 7 peptidespecificities peptidespecificitie NNS cord-013590-pkm81fq1 166 8 of of IN cord-013590-pkm81fq1 166 9 γδ γδ NNP cord-013590-pkm81fq1 166 10 TCRs TCRs NNP cord-013590-pkm81fq1 166 11 mice mouse NNS cord-013590-pkm81fq1 166 12 are be VBP cord-013590-pkm81fq1 166 13 mediated mediate VBN cord-013590-pkm81fq1 166 14 via via IN cord-013590-pkm81fq1 166 15 Vγ1 vγ1 NN cord-013590-pkm81fq1 166 16 + + SYM cord-013590-pkm81fq1 166 17 TCRs tcr NNS cord-013590-pkm81fq1 166 18 . . . cord-013590-pkm81fq1 167 1 113 113 CD cord-013590-pkm81fq1 168 1 Ligand ligand NN cord-013590-pkm81fq1 168 2 recognition recognition NN cord-013590-pkm81fq1 168 3 by by IN cord-013590-pkm81fq1 168 4 the the DT cord-013590-pkm81fq1 168 5 γδ γδ NNP cord-013590-pkm81fq1 168 6 TCR TCR NNP cord-013590-pkm81fq1 168 7 and and CC cord-013590-pkm81fq1 168 8 discrimination discrimination NN cord-013590-pkm81fq1 168 9 between between IN cord-013590-pkm81fq1 168 10 homeostasis homeostasis NN cord-013590-pkm81fq1 168 11 . . . cord-013590-pkm81fq1 168 12 . . . cord-013590-pkm81fq1 168 13 . . . cord-013590-pkm81fq1 169 1 M M NNP cord-013590-pkm81fq1 169 2 Deseke Deseke NNP cord-013590-pkm81fq1 169 3 and and CC cord-013590-pkm81fq1 169 4 I -PRON- PRP cord-013590-pkm81fq1 170 1 Prinz Prinz NNP cord-013590-pkm81fq1 171 1 Although although IN cord-013590-pkm81fq1 171 2 the the DT cord-013590-pkm81fq1 171 3 peptides peptide NNS cord-013590-pkm81fq1 171 4 described describe VBN cord-013590-pkm81fq1 171 5 are be VBP cord-013590-pkm81fq1 171 6 not not RB cord-013590-pkm81fq1 171 7 necessarily necessarily RB cord-013590-pkm81fq1 171 8 polyanionic polyanionic JJ cord-013590-pkm81fq1 171 9 , , , cord-013590-pkm81fq1 171 10 reactivity reactivity NN cord-013590-pkm81fq1 171 11 for for IN cord-013590-pkm81fq1 171 12 short short JJ cord-013590-pkm81fq1 171 13 polymeric polymeric JJ cord-013590-pkm81fq1 171 14 sequences sequence NNS cord-013590-pkm81fq1 171 15 by by IN cord-013590-pkm81fq1 171 16 this this DT cord-013590-pkm81fq1 171 17 group group NN cord-013590-pkm81fq1 171 18 of of IN cord-013590-pkm81fq1 171 19 TCRs tcr NNS cord-013590-pkm81fq1 171 20 might may MD cord-013590-pkm81fq1 171 21 be be VB cord-013590-pkm81fq1 171 22 a a DT cord-013590-pkm81fq1 171 23 common common JJ cord-013590-pkm81fq1 171 24 feature feature NN cord-013590-pkm81fq1 171 25 that that WDT cord-013590-pkm81fq1 171 26 is be VBZ cord-013590-pkm81fq1 171 27 , , , cord-013590-pkm81fq1 171 28 however however RB cord-013590-pkm81fq1 171 29 , , , cord-013590-pkm81fq1 171 30 probably probably RB cord-013590-pkm81fq1 171 31 not not RB cord-013590-pkm81fq1 171 32 CDR3 CDR3 NNP cord-013590-pkm81fq1 171 33 dependent dependent JJ cord-013590-pkm81fq1 171 34 . . . cord-013590-pkm81fq1 172 1 Together together RB cord-013590-pkm81fq1 172 2 with with IN cord-013590-pkm81fq1 172 3 the the DT cord-013590-pkm81fq1 172 4 different different JJ cord-013590-pkm81fq1 172 5 MHC MHC NNP cord-013590-pkm81fq1 172 6 and and CC cord-013590-pkm81fq1 172 7 MHC MHC NNP cord-013590-pkm81fq1 172 8 - - HYPH cord-013590-pkm81fq1 172 9 like like JJ cord-013590-pkm81fq1 172 10 molecules molecule NNS cord-013590-pkm81fq1 172 11 , , , cord-013590-pkm81fq1 172 12 these these DT cord-013590-pkm81fq1 172 13 examples example NNS cord-013590-pkm81fq1 172 14 of of IN cord-013590-pkm81fq1 172 15 recognized recognize VBN cord-013590-pkm81fq1 172 16 molecules molecule NNS cord-013590-pkm81fq1 172 17 illustrate illustrate VBP cord-013590-pkm81fq1 172 18 the the DT cord-013590-pkm81fq1 172 19 high high JJ cord-013590-pkm81fq1 172 20 diversity diversity NN cord-013590-pkm81fq1 172 21 of of IN cord-013590-pkm81fq1 172 22 ligands ligand NNS cord-013590-pkm81fq1 172 23 for for IN cord-013590-pkm81fq1 172 24 the the DT cord-013590-pkm81fq1 172 25 γδ γδ NN cord-013590-pkm81fq1 173 1 TCR TCR NNP cord-013590-pkm81fq1 173 2 that that WDT cord-013590-pkm81fq1 173 3 is be VBZ cord-013590-pkm81fq1 173 4 in in IN cord-013590-pkm81fq1 173 5 contrast contrast NN cord-013590-pkm81fq1 173 6 to to IN cord-013590-pkm81fq1 173 7 αβ αβ NNP cord-013590-pkm81fq1 173 8 TCRs TCRs NNP cord-013590-pkm81fq1 173 9 , , , cord-013590-pkm81fq1 173 10 which which WDT cord-013590-pkm81fq1 173 11 can can MD cord-013590-pkm81fq1 173 12 recognize recognize VB cord-013590-pkm81fq1 173 13 a a DT cord-013590-pkm81fq1 173 14 wide wide JJ cord-013590-pkm81fq1 173 15 range range NN cord-013590-pkm81fq1 173 16 of of IN cord-013590-pkm81fq1 173 17 peptides peptide NNS cord-013590-pkm81fq1 173 18 but but CC cord-013590-pkm81fq1 173 19 all all DT cord-013590-pkm81fq1 173 20 in in IN cord-013590-pkm81fq1 173 21 the the DT cord-013590-pkm81fq1 173 22 context context NN cord-013590-pkm81fq1 173 23 of of IN cord-013590-pkm81fq1 173 24 the the DT cord-013590-pkm81fq1 173 25 less less RBR cord-013590-pkm81fq1 173 26 polymorphic polymorphic JJ cord-013590-pkm81fq1 173 27 MHC MHC NNP cord-013590-pkm81fq1 173 28 class class NN cord-013590-pkm81fq1 173 29 I i NN cord-013590-pkm81fq1 173 30 and and CC cord-013590-pkm81fq1 173 31 II II NNP cord-013590-pkm81fq1 173 32 molecules molecule NNS cord-013590-pkm81fq1 173 33 . . . cord-013590-pkm81fq1 174 1 Furthermore furthermore RB cord-013590-pkm81fq1 174 2 , , , cord-013590-pkm81fq1 174 3 comparison comparison NN cord-013590-pkm81fq1 174 4 of of IN cord-013590-pkm81fq1 174 5 the the DT cord-013590-pkm81fq1 174 6 CDR3 CDR3 NNP cord-013590-pkm81fq1 174 7 lengths length NNS cord-013590-pkm81fq1 174 8 between between IN cord-013590-pkm81fq1 174 9 the the DT cord-013590-pkm81fq1 174 10 different different JJ cord-013590-pkm81fq1 174 11 adaptive adaptive JJ cord-013590-pkm81fq1 174 12 immune immune JJ cord-013590-pkm81fq1 174 13 receptors receptor NNS cord-013590-pkm81fq1 174 14 revealed reveal VBD cord-013590-pkm81fq1 174 15 that that IN cord-013590-pkm81fq1 174 16 overall overall JJ cord-013590-pkm81fq1 174 17 γδ γδ IN cord-013590-pkm81fq1 174 18 TCRs tcr NNS cord-013590-pkm81fq1 174 19 resemble resemble VBP cord-013590-pkm81fq1 174 20 more more JJR cord-013590-pkm81fq1 174 21 immunoglobulins immunoglobulin NNS cord-013590-pkm81fq1 174 22 with with IN cord-013590-pkm81fq1 174 23 a a DT cord-013590-pkm81fq1 174 24 shorter short JJR cord-013590-pkm81fq1 174 25 CDR3γ cdr3γ NN cord-013590-pkm81fq1 174 26 and and CC cord-013590-pkm81fq1 174 27 a a DT cord-013590-pkm81fq1 174 28 longer long RBR cord-013590-pkm81fq1 174 29 CDR3δ CDR3δ NNP cord-013590-pkm81fq1 174 30 , , , cord-013590-pkm81fq1 174 31 which which WDT cord-013590-pkm81fq1 174 32 is be VBZ cord-013590-pkm81fq1 174 33 in in IN cord-013590-pkm81fq1 174 34 contrast contrast NN cord-013590-pkm81fq1 174 35 to to IN cord-013590-pkm81fq1 174 36 CDR3α CDR3α NNP cord-013590-pkm81fq1 175 1 and and CC cord-013590-pkm81fq1 175 2 CDR3β cdr3β NN cord-013590-pkm81fq1 175 3 that that WDT cord-013590-pkm81fq1 175 4 have have VBP cord-013590-pkm81fq1 175 5 comparable comparable JJ cord-013590-pkm81fq1 175 6 lengths length NNS cord-013590-pkm81fq1 175 7 . . . cord-013590-pkm81fq1 176 1 75 75 CD cord-013590-pkm81fq1 177 1 Although although IN cord-013590-pkm81fq1 177 2 recognition recognition NN cord-013590-pkm81fq1 177 3 of of IN cord-013590-pkm81fq1 177 4 antigen antigen NN cord-013590-pkm81fq1 177 5 by by IN cord-013590-pkm81fq1 177 6 VDJ VDJ NNP cord-013590-pkm81fq1 177 7 - - HYPH cord-013590-pkm81fq1 177 8 recombined recombine VBN cord-013590-pkm81fq1 177 9 adaptive adaptive JJ cord-013590-pkm81fq1 177 10 immune immune JJ cord-013590-pkm81fq1 177 11 receptors receptor NNS cord-013590-pkm81fq1 177 12 depends depend VBZ cord-013590-pkm81fq1 177 13 on on IN cord-013590-pkm81fq1 177 14 more more JJR cord-013590-pkm81fq1 177 15 factors factor NNS cord-013590-pkm81fq1 177 16 than than IN cord-013590-pkm81fq1 177 17 the the DT cord-013590-pkm81fq1 177 18 mere mere JJ cord-013590-pkm81fq1 177 19 CDR3 CDR3 NNP cord-013590-pkm81fq1 177 20 length length NN cord-013590-pkm81fq1 177 21 , , , cord-013590-pkm81fq1 177 22 this this DT cord-013590-pkm81fq1 177 23 points point VBZ cord-013590-pkm81fq1 177 24 to to IN cord-013590-pkm81fq1 177 25 an an DT cord-013590-pkm81fq1 177 26 antigen antigen NN cord-013590-pkm81fq1 177 27 - - HYPH cord-013590-pkm81fq1 177 28 binding bind VBG cord-013590-pkm81fq1 177 29 mode mode NN cord-013590-pkm81fq1 177 30 of of IN cord-013590-pkm81fq1 177 31 γδ γδ IN cord-013590-pkm81fq1 177 32 TCRs tcr NNS cord-013590-pkm81fq1 177 33 that that WDT cord-013590-pkm81fq1 177 34 is be VBZ cord-013590-pkm81fq1 177 35 substantially substantially RB cord-013590-pkm81fq1 177 36 different different JJ cord-013590-pkm81fq1 177 37 from from IN cord-013590-pkm81fq1 177 38 αβ αβ NNP cord-013590-pkm81fq1 177 39 TCRs TCRs NNP cord-013590-pkm81fq1 177 40 . . . cord-013590-pkm81fq1 178 1 Together together RB cord-013590-pkm81fq1 178 2 with with IN cord-013590-pkm81fq1 178 3 the the DT cord-013590-pkm81fq1 178 4 great great JJ cord-013590-pkm81fq1 178 5 variety variety NN cord-013590-pkm81fq1 178 6 of of IN cord-013590-pkm81fq1 178 7 γδ γδ XX cord-013590-pkm81fq1 179 1 TCR TCR NNP cord-013590-pkm81fq1 179 2 antigens antigen NNS cord-013590-pkm81fq1 180 1 this this DT cord-013590-pkm81fq1 180 2 has have VBZ cord-013590-pkm81fq1 180 3 led lead VBN cord-013590-pkm81fq1 180 4 to to IN cord-013590-pkm81fq1 180 5 the the DT cord-013590-pkm81fq1 180 6 concept concept NN cord-013590-pkm81fq1 180 7 of of IN cord-013590-pkm81fq1 180 8 a a DT cord-013590-pkm81fq1 180 9 rather rather RB cord-013590-pkm81fq1 180 10 immunoglobulin immunoglobulin NN cord-013590-pkm81fq1 180 11 - - HYPH cord-013590-pkm81fq1 180 12 like like JJ cord-013590-pkm81fq1 180 13 ( ( -LRB- cord-013590-pkm81fq1 180 14 Ig Ig NNP cord-013590-pkm81fq1 180 15 - - HYPH cord-013590-pkm81fq1 180 16 like like JJ cord-013590-pkm81fq1 180 17 ) ) -RRB- cord-013590-pkm81fq1 180 18 recognition recognition NN cord-013590-pkm81fq1 180 19 of of IN cord-013590-pkm81fq1 180 20 antigens antigen NNS cord-013590-pkm81fq1 180 21 by by IN cord-013590-pkm81fq1 180 22 γδ γδ IN cord-013590-pkm81fq1 180 23 TCRs tcr NNS cord-013590-pkm81fq1 180 24 . . . cord-013590-pkm81fq1 181 1 76 76 CD cord-013590-pkm81fq1 182 1 In in IN cord-013590-pkm81fq1 182 2 accordance accordance NN cord-013590-pkm81fq1 182 3 with with IN cord-013590-pkm81fq1 182 4 this this DT cord-013590-pkm81fq1 182 5 , , , cord-013590-pkm81fq1 182 6 similar similar JJ cord-013590-pkm81fq1 182 7 to to IN cord-013590-pkm81fq1 182 8 immunoglobulins immunoglobulin NNS cord-013590-pkm81fq1 182 9 , , , cord-013590-pkm81fq1 182 10 γδ γδ CC cord-013590-pkm81fq1 182 11 TCRs tcr NNS cord-013590-pkm81fq1 182 12 seem seem VBP cord-013590-pkm81fq1 182 13 to to TO cord-013590-pkm81fq1 182 14 be be VB cord-013590-pkm81fq1 182 15 able able JJ cord-013590-pkm81fq1 182 16 to to TO cord-013590-pkm81fq1 182 17 recognize recognize VB cord-013590-pkm81fq1 182 18 structural structural JJ cord-013590-pkm81fq1 182 19 as as RB cord-013590-pkm81fq1 182 20 well well RB cord-013590-pkm81fq1 182 21 as as IN cord-013590-pkm81fq1 182 22 sequence sequence NN cord-013590-pkm81fq1 182 23 epitopes epitope NNS cord-013590-pkm81fq1 182 24 . . . cord-013590-pkm81fq1 183 1 Moreover moreover RB cord-013590-pkm81fq1 183 2 , , , cord-013590-pkm81fq1 183 3 the the DT cord-013590-pkm81fq1 183 4 fact fact NN cord-013590-pkm81fq1 183 5 that that IN cord-013590-pkm81fq1 183 6 many many JJ cord-013590-pkm81fq1 183 7 different different JJ cord-013590-pkm81fq1 183 8 γδ γδ IN cord-013590-pkm81fq1 183 9 TCRs tcr NNS cord-013590-pkm81fq1 183 10 can can MD cord-013590-pkm81fq1 183 11 be be VB cord-013590-pkm81fq1 183 12 specific specific JJ cord-013590-pkm81fq1 183 13 for for IN cord-013590-pkm81fq1 183 14 the the DT cord-013590-pkm81fq1 183 15 same same JJ cord-013590-pkm81fq1 183 16 target target NN cord-013590-pkm81fq1 183 17 molecule molecule NN cord-013590-pkm81fq1 183 18 as as IN cord-013590-pkm81fq1 183 19 e.g. e.g. RB cord-013590-pkm81fq1 183 20 , , , cord-013590-pkm81fq1 183 21 in in IN cord-013590-pkm81fq1 183 22 the the DT cord-013590-pkm81fq1 183 23 case case NN cord-013590-pkm81fq1 183 24 of of IN cord-013590-pkm81fq1 183 25 PE PE NNP cord-013590-pkm81fq1 183 26 , , , cord-013590-pkm81fq1 183 27 CD1-d CD1-d NNP cord-013590-pkm81fq1 183 28 , , , cord-013590-pkm81fq1 183 29 or or CC cord-013590-pkm81fq1 183 30 MR-1 MR-1 NNP cord-013590-pkm81fq1 183 31 is be VBZ cord-013590-pkm81fq1 183 32 reminiscent reminiscent JJ cord-013590-pkm81fq1 183 33 of of IN cord-013590-pkm81fq1 183 34 polyclonal polyclonal JJ cord-013590-pkm81fq1 183 35 antibodies antibody NNS cord-013590-pkm81fq1 183 36 with with IN cord-013590-pkm81fq1 183 37 the the DT cord-013590-pkm81fq1 183 38 same same JJ cord-013590-pkm81fq1 183 39 target target NN cord-013590-pkm81fq1 183 40 specificities specificity NNS cord-013590-pkm81fq1 183 41 but but CC cord-013590-pkm81fq1 183 42 different different JJ cord-013590-pkm81fq1 183 43 binding binding NN cord-013590-pkm81fq1 183 44 modes mode NNS cord-013590-pkm81fq1 183 45 . . . cord-013590-pkm81fq1 184 1 Despite despite IN cord-013590-pkm81fq1 184 2 these these DT cord-013590-pkm81fq1 184 3 striking strike VBG cord-013590-pkm81fq1 184 4 similarities similarity NNS cord-013590-pkm81fq1 184 5 between between IN cord-013590-pkm81fq1 184 6 γδ γδ XX cord-013590-pkm81fq1 184 7 TCRs tcr NNS cord-013590-pkm81fq1 184 8 and and CC cord-013590-pkm81fq1 184 9 immunoglobulins immunoglobulin NNS cord-013590-pkm81fq1 184 10 with with IN cord-013590-pkm81fq1 184 11 regard regard NN cord-013590-pkm81fq1 184 12 to to IN cord-013590-pkm81fq1 184 13 their -PRON- PRP$ cord-013590-pkm81fq1 184 14 antigen antigen NN cord-013590-pkm81fq1 184 15 recognition recognition NN cord-013590-pkm81fq1 184 16 properties property NNS cord-013590-pkm81fq1 184 17 , , , cord-013590-pkm81fq1 184 18 one one PRP cord-013590-pkm81fq1 184 19 should should MD cord-013590-pkm81fq1 184 20 always always RB cord-013590-pkm81fq1 184 21 bear bear VB cord-013590-pkm81fq1 184 22 in in IN cord-013590-pkm81fq1 184 23 mind mind NN cord-013590-pkm81fq1 184 24 that that IN cord-013590-pkm81fq1 184 25 fundamental fundamental JJ cord-013590-pkm81fq1 184 26 differences difference NNS cord-013590-pkm81fq1 184 27 exist exist VBP cord-013590-pkm81fq1 184 28 . . . cord-013590-pkm81fq1 185 1 The the DT cord-013590-pkm81fq1 185 2 affinity affinity NN cord-013590-pkm81fq1 185 3 of of IN cord-013590-pkm81fq1 185 4 most most JJS cord-013590-pkm81fq1 185 5 γδ γδ IN cord-013590-pkm81fq1 185 6 TCRs tcr NNS cord-013590-pkm81fq1 185 7 for for IN cord-013590-pkm81fq1 185 8 their -PRON- PRP$ cord-013590-pkm81fq1 185 9 antigens antigen NNS cord-013590-pkm81fq1 185 10 is be VBZ cord-013590-pkm81fq1 185 11 low low JJ cord-013590-pkm81fq1 185 12 in in IN cord-013590-pkm81fq1 185 13 contrast contrast NN cord-013590-pkm81fq1 185 14 to to IN cord-013590-pkm81fq1 185 15 high high JJ cord-013590-pkm81fq1 185 16 - - HYPH cord-013590-pkm81fq1 185 17 affinity affinity NN cord-013590-pkm81fq1 185 18 antibodies antibody NNS cord-013590-pkm81fq1 185 19 , , , cord-013590-pkm81fq1 185 20 which which WDT cord-013590-pkm81fq1 185 21 has have VBZ cord-013590-pkm81fq1 185 22 important important JJ cord-013590-pkm81fq1 185 23 considerations consideration NNS cord-013590-pkm81fq1 185 24 for for IN cord-013590-pkm81fq1 185 25 technical technical JJ cord-013590-pkm81fq1 185 26 applications application NNS cord-013590-pkm81fq1 185 27 , , , cord-013590-pkm81fq1 185 28 such such JJ cord-013590-pkm81fq1 185 29 as as IN cord-013590-pkm81fq1 185 30 flow flow NN cord-013590-pkm81fq1 185 31 cytometry cytometry NN cord-013590-pkm81fq1 185 32 or or CC cord-013590-pkm81fq1 185 33 co co NN cord-013590-pkm81fq1 185 34 - - NN cord-013590-pkm81fq1 185 35 immunoprecipitation immunoprecipitation JJ cord-013590-pkm81fq1 185 36 . . . cord-013590-pkm81fq1 186 1 Due due IN cord-013590-pkm81fq1 186 2 to to IN cord-013590-pkm81fq1 186 3 the the DT cord-013590-pkm81fq1 186 4 high high JJ cord-013590-pkm81fq1 186 5 density density NN cord-013590-pkm81fq1 186 6 of of IN cord-013590-pkm81fq1 186 7 γδ γδ NN cord-013590-pkm81fq1 187 1 TCR TCR NNP cord-013590-pkm81fq1 187 2 molecules molecule NNS cord-013590-pkm81fq1 187 3 on on IN cord-013590-pkm81fq1 187 4 the the DT cord-013590-pkm81fq1 187 5 cell cell NN cord-013590-pkm81fq1 187 6 surface surface NN cord-013590-pkm81fq1 187 7 in in IN cord-013590-pkm81fq1 187 8 physiological physiological JJ cord-013590-pkm81fq1 187 9 contexts context NNS cord-013590-pkm81fq1 187 10 and and CC cord-013590-pkm81fq1 187 11 similarly similarly RB cord-013590-pkm81fq1 187 12 high high JJ cord-013590-pkm81fq1 187 13 expression expression NN cord-013590-pkm81fq1 187 14 of of IN cord-013590-pkm81fq1 187 15 the the DT cord-013590-pkm81fq1 187 16 respective respective JJ cord-013590-pkm81fq1 187 17 ligands ligand NNS cord-013590-pkm81fq1 187 18 , , , cord-013590-pkm81fq1 187 19 the the DT cord-013590-pkm81fq1 187 20 high high JJ cord-013590-pkm81fq1 187 21 avidity avidity NN cord-013590-pkm81fq1 187 22 of of IN cord-013590-pkm81fq1 187 23 this this DT cord-013590-pkm81fq1 187 24 interaction interaction NN cord-013590-pkm81fq1 187 25 probably probably RB cord-013590-pkm81fq1 187 26 circumvents circumvent VBZ cord-013590-pkm81fq1 187 27 the the DT cord-013590-pkm81fq1 187 28 single single JJ cord-013590-pkm81fq1 187 29 molecule molecule NN cord-013590-pkm81fq1 187 30 lowaffinity lowaffinity NN cord-013590-pkm81fq1 187 31 binding binding NN cord-013590-pkm81fq1 187 32 . . . cord-013590-pkm81fq1 188 1 77 77 CD cord-013590-pkm81fq1 189 1 To to TO cord-013590-pkm81fq1 189 2 what what WDT cord-013590-pkm81fq1 189 3 extent extent NN cord-013590-pkm81fq1 189 4 a a DT cord-013590-pkm81fq1 189 5 possible possible JJ cord-013590-pkm81fq1 189 6 Ig Ig NNP cord-013590-pkm81fq1 189 7 - - HYPH cord-013590-pkm81fq1 189 8 like like JJ cord-013590-pkm81fq1 189 9 antigen antigen NN cord-013590-pkm81fq1 189 10 recognition recognition NN cord-013590-pkm81fq1 189 11 by by IN cord-013590-pkm81fq1 189 12 γδ γδ NNP cord-013590-pkm81fq1 189 13 TCRs TCRs NNP cord-013590-pkm81fq1 189 14 plays play VBZ cord-013590-pkm81fq1 189 15 a a DT cord-013590-pkm81fq1 189 16 role role NN cord-013590-pkm81fq1 189 17 in in IN cord-013590-pkm81fq1 189 18 vivo vivo NNP cord-013590-pkm81fq1 189 19 remains remain VBZ cord-013590-pkm81fq1 189 20 a a DT cord-013590-pkm81fq1 189 21 matter matter NN cord-013590-pkm81fq1 189 22 of of IN cord-013590-pkm81fq1 189 23 debate debate NN cord-013590-pkm81fq1 189 24 . . . cord-013590-pkm81fq1 190 1 In in IN cord-013590-pkm81fq1 190 2 humans human NNS cord-013590-pkm81fq1 190 3 the the DT cord-013590-pkm81fq1 190 4 largest large JJS cord-013590-pkm81fq1 190 5 subset subset NN cord-013590-pkm81fq1 190 6 of of IN cord-013590-pkm81fq1 190 7 γδ γδ NN cord-013590-pkm81fq1 190 8 T t NN cord-013590-pkm81fq1 190 9 cells cell NNS cord-013590-pkm81fq1 190 10 in in IN cord-013590-pkm81fq1 190 11 peripheral peripheral JJ cord-013590-pkm81fq1 190 12 blood blood NN cord-013590-pkm81fq1 190 13 express express VBP cord-013590-pkm81fq1 190 14 a a DT cord-013590-pkm81fq1 190 15 semi semi JJ cord-013590-pkm81fq1 190 16 - - JJ cord-013590-pkm81fq1 190 17 invariant invariant JJ cord-013590-pkm81fq1 190 18 TCR TCR NNP cord-013590-pkm81fq1 190 19 composed compose VBN cord-013590-pkm81fq1 190 20 of of IN cord-013590-pkm81fq1 190 21 a a DT cord-013590-pkm81fq1 190 22 restricted restricted JJ cord-013590-pkm81fq1 190 23 Vγ9JP vγ9jp NN cord-013590-pkm81fq1 190 24 rearrangement rearrangement NN cord-013590-pkm81fq1 190 25 together together RB cord-013590-pkm81fq1 190 26 with with IN cord-013590-pkm81fq1 190 27 a a DT cord-013590-pkm81fq1 190 28 more more RBR cord-013590-pkm81fq1 190 29 diverse diverse JJ cord-013590-pkm81fq1 190 30 Vδ2 vδ2 NN cord-013590-pkm81fq1 190 31 chain chain NN cord-013590-pkm81fq1 190 32 . . . cord-013590-pkm81fq1 191 1 78 78 CD cord-013590-pkm81fq1 192 1 This this DT cord-013590-pkm81fq1 192 2 subset subset NN cord-013590-pkm81fq1 192 3 is be VBZ cord-013590-pkm81fq1 192 4 also also RB cord-013590-pkm81fq1 192 5 found find VBN cord-013590-pkm81fq1 192 6 in in IN cord-013590-pkm81fq1 192 7 other other JJ cord-013590-pkm81fq1 192 8 species specie NNS cord-013590-pkm81fq1 192 9 , , , cord-013590-pkm81fq1 192 10 e.g. e.g. RB cord-013590-pkm81fq1 192 11 , , , cord-013590-pkm81fq1 192 12 in in IN cord-013590-pkm81fq1 192 13 non non JJ cord-013590-pkm81fq1 192 14 - - JJ cord-013590-pkm81fq1 192 15 human human JJ cord-013590-pkm81fq1 192 16 primates primate NNS cord-013590-pkm81fq1 192 17 79,80 79,80 CD cord-013590-pkm81fq1 192 18 or or CC cord-013590-pkm81fq1 192 19 alpaca alpaca NN cord-013590-pkm81fq1 192 20 but but CC cord-013590-pkm81fq1 192 21 not not RB cord-013590-pkm81fq1 192 22 in in IN cord-013590-pkm81fq1 192 23 rodents rodent NNS cord-013590-pkm81fq1 192 24 . . . cord-013590-pkm81fq1 193 1 81 81 CD cord-013590-pkm81fq1 193 2 , , , cord-013590-pkm81fq1 194 1 82 82 CD cord-013590-pkm81fq1 194 2 Vγ9Vδ2 Vγ9Vδ2 NNS cord-013590-pkm81fq1 194 3 + + CC cord-013590-pkm81fq1 194 4 TCRs TCRs NNPS cord-013590-pkm81fq1 194 5 recognize recognize VB cord-013590-pkm81fq1 194 6 small small JJ cord-013590-pkm81fq1 194 7 non non JJ cord-013590-pkm81fq1 194 8 - - JJ cord-013590-pkm81fq1 194 9 proteogenic proteogenic JJ cord-013590-pkm81fq1 194 10 phosphorylated phosphorylated JJ cord-013590-pkm81fq1 194 11 molecules molecule NNS cord-013590-pkm81fq1 194 12 termed term VBD cord-013590-pkm81fq1 194 13 phosphoantigens phosphoantigen NNS cord-013590-pkm81fq1 194 14 ( ( -LRB- cord-013590-pkm81fq1 194 15 p p NN cord-013590-pkm81fq1 194 16 - - : cord-013590-pkm81fq1 194 17 Ags Ags NNP cord-013590-pkm81fq1 194 18 ) ) -RRB- cord-013590-pkm81fq1 194 19 in in IN cord-013590-pkm81fq1 194 20 an an DT cord-013590-pkm81fq1 194 21 MHC MHC NNP cord-013590-pkm81fq1 194 22 - - HYPH cord-013590-pkm81fq1 194 23 independent independent JJ cord-013590-pkm81fq1 194 24 way way NN cord-013590-pkm81fq1 194 25 . . . cord-013590-pkm81fq1 195 1 83 83 CD cord-013590-pkm81fq1 196 1 The the DT cord-013590-pkm81fq1 196 2 most most RBS cord-013590-pkm81fq1 196 3 potent potent JJ cord-013590-pkm81fq1 196 4 p p NN cord-013590-pkm81fq1 196 5 - - : cord-013590-pkm81fq1 196 6 Ag Ag NNP cord-013590-pkm81fq1 196 7 is be VBZ cord-013590-pkm81fq1 196 8 ( ( -LRB- cord-013590-pkm81fq1 196 9 E)-4-hydroxy-3-methyl E)-4-hydroxy-3-methyl NNP cord-013590-pkm81fq1 196 10 - - HYPH cord-013590-pkm81fq1 196 11 but-2-enyl but-2-enyl JJ cord-013590-pkm81fq1 196 12 pyrophosphate pyrophosphate NN cord-013590-pkm81fq1 196 13 ( ( -LRB- cord-013590-pkm81fq1 196 14 HMBPP HMBPP NNP cord-013590-pkm81fq1 196 15 ) ) -RRB- cord-013590-pkm81fq1 196 16 , , , cord-013590-pkm81fq1 196 17 an an DT cord-013590-pkm81fq1 196 18 intermediate intermediate NN cord-013590-pkm81fq1 196 19 of of IN cord-013590-pkm81fq1 196 20 the the DT cord-013590-pkm81fq1 196 21 prokaryotic prokaryotic JJ cord-013590-pkm81fq1 196 22 non non JJ cord-013590-pkm81fq1 196 23 - - JJ cord-013590-pkm81fq1 196 24 mevalonate mevalonate JJ cord-013590-pkm81fq1 196 25 pathway pathway NN cord-013590-pkm81fq1 196 26 of of IN cord-013590-pkm81fq1 196 27 isoprenoid isoprenoid NNP cord-013590-pkm81fq1 196 28 biosynthesis biosynthesis NNP cord-013590-pkm81fq1 196 29 . . . cord-013590-pkm81fq1 197 1 Isopentenyl Isopentenyl NNP cord-013590-pkm81fq1 197 2 pyrophosphate pyrophosphate NN cord-013590-pkm81fq1 197 3 ( ( -LRB- cord-013590-pkm81fq1 197 4 IPP IPP NNP cord-013590-pkm81fq1 197 5 ) ) -RRB- cord-013590-pkm81fq1 197 6 and and CC cord-013590-pkm81fq1 197 7 dimethylallyl dimethylallyl NNP cord-013590-pkm81fq1 197 8 pyrophosphate pyrophosphate NN cord-013590-pkm81fq1 197 9 ( ( -LRB- cord-013590-pkm81fq1 197 10 DMAPP DMAPP NNP cord-013590-pkm81fq1 197 11 ) ) -RRB- cord-013590-pkm81fq1 197 12 are be VBP cord-013590-pkm81fq1 197 13 present present JJ cord-013590-pkm81fq1 197 14 in in IN cord-013590-pkm81fq1 197 15 both both DT cord-013590-pkm81fq1 197 16 prokaryotes prokaryote NNS cord-013590-pkm81fq1 197 17 and and CC cord-013590-pkm81fq1 197 18 eukaryotes eukaryote NNS cord-013590-pkm81fq1 197 19 . . . cord-013590-pkm81fq1 198 1 However however RB cord-013590-pkm81fq1 198 2 , , , cord-013590-pkm81fq1 198 3 their -PRON- PRP$ cord-013590-pkm81fq1 198 4 efficiency efficiency NN cord-013590-pkm81fq1 198 5 to to TO cord-013590-pkm81fq1 198 6 activate activate VB cord-013590-pkm81fq1 198 7 Vγ9Vδ2 Vγ9Vδ2 NNS cord-013590-pkm81fq1 198 8 + + CC cord-013590-pkm81fq1 198 9 TCRs tcr NNS cord-013590-pkm81fq1 198 10 is be VBZ cord-013590-pkm81fq1 198 11 lower low JJR cord-013590-pkm81fq1 198 12 compared compare VBN cord-013590-pkm81fq1 198 13 to to IN cord-013590-pkm81fq1 198 14 HMBPP HMBPP NNP cord-013590-pkm81fq1 198 15 . . . cord-013590-pkm81fq1 199 1 IPP IPP NNP cord-013590-pkm81fq1 199 2 and and CC cord-013590-pkm81fq1 199 3 DMAPP DMAPP NNP cord-013590-pkm81fq1 199 4 can can MD cord-013590-pkm81fq1 199 5 accumulate accumulate VB cord-013590-pkm81fq1 199 6 inside inside IN cord-013590-pkm81fq1 199 7 eukaryotic eukaryotic JJ cord-013590-pkm81fq1 199 8 cells cell NNS cord-013590-pkm81fq1 199 9 in in IN cord-013590-pkm81fq1 199 10 response response NN cord-013590-pkm81fq1 199 11 to to TO cord-013590-pkm81fq1 199 12 stress stress NN cord-013590-pkm81fq1 199 13 situations situation NNS cord-013590-pkm81fq1 199 14 e.g. e.g. RB cord-013590-pkm81fq1 199 15 , , , cord-013590-pkm81fq1 199 16 infection infection NN cord-013590-pkm81fq1 199 17 or or CC cord-013590-pkm81fq1 199 18 malignant malignant JJ cord-013590-pkm81fq1 199 19 transformation transformation NN cord-013590-pkm81fq1 199 20 whereas whereas IN cord-013590-pkm81fq1 199 21 HMBPP HMBPP NNP cord-013590-pkm81fq1 199 22 is be VBZ cord-013590-pkm81fq1 199 23 produced produce VBN cord-013590-pkm81fq1 199 24 directly directly RB cord-013590-pkm81fq1 199 25 by by IN cord-013590-pkm81fq1 199 26 pathogens pathogen NNS cord-013590-pkm81fq1 199 27 such such JJ cord-013590-pkm81fq1 199 28 as as IN cord-013590-pkm81fq1 199 29 grampositive grampositive JJ cord-013590-pkm81fq1 199 30 bacteria bacteria NNS cord-013590-pkm81fq1 199 31 , , , cord-013590-pkm81fq1 199 32 Plasmodium plasmodium NN cord-013590-pkm81fq1 199 33 or or CC cord-013590-pkm81fq1 199 34 Toxoplasma toxoplasma NN cord-013590-pkm81fq1 199 35 gondii gondii NN cord-013590-pkm81fq1 199 36 . . . cord-013590-pkm81fq1 200 1 84 84 CD cord-013590-pkm81fq1 201 1 Besides besides IN cord-013590-pkm81fq1 201 2 the the DT cord-013590-pkm81fq1 201 3 naturally naturally RB cord-013590-pkm81fq1 201 4 occurring occur VBG cord-013590-pkm81fq1 201 5 p p NN cord-013590-pkm81fq1 201 6 - - : cord-013590-pkm81fq1 201 7 Ags Ags NNP cord-013590-pkm81fq1 201 8 , , , cord-013590-pkm81fq1 201 9 synthetic synthetic JJ cord-013590-pkm81fq1 201 10 aminobisphosphonates aminobisphosphonate NNS cord-013590-pkm81fq1 201 11 as as IN cord-013590-pkm81fq1 201 12 alendronate alendronate NNP cord-013590-pkm81fq1 201 13 , , , cord-013590-pkm81fq1 201 14 zoledronate zoledronate NNP cord-013590-pkm81fq1 201 15 or or CC cord-013590-pkm81fq1 201 16 pamidronate pamidronate NNP cord-013590-pkm81fq1 201 17 can can MD cord-013590-pkm81fq1 201 18 activate activate VB cord-013590-pkm81fq1 201 19 Vγ9Vδ2 Vγ9Vδ2 NNS cord-013590-pkm81fq1 201 20 + + CC cord-013590-pkm81fq1 201 21 TCRs tcr NNS cord-013590-pkm81fq1 201 22 by by IN cord-013590-pkm81fq1 201 23 inhibiting inhibit VBG cord-013590-pkm81fq1 201 24 the the DT cord-013590-pkm81fq1 201 25 enzyme enzyme NN cord-013590-pkm81fq1 201 26 farnesyl farnesyl NNP cord-013590-pkm81fq1 201 27 pyrophosphate pyrophosphate NN cord-013590-pkm81fq1 201 28 synthase synthase NN cord-013590-pkm81fq1 201 29 in in IN cord-013590-pkm81fq1 201 30 the the DT cord-013590-pkm81fq1 201 31 mevalonate mevalonate NNP cord-013590-pkm81fq1 201 32 pathway pathway NN cord-013590-pkm81fq1 201 33 of of IN cord-013590-pkm81fq1 201 34 eukaryotic eukaryotic JJ cord-013590-pkm81fq1 201 35 isoprenoid isoprenoid NNP cord-013590-pkm81fq1 201 36 biosynthesis biosynthesis NN cord-013590-pkm81fq1 201 37 leading lead VBG cord-013590-pkm81fq1 201 38 to to IN cord-013590-pkm81fq1 201 39 an an DT cord-013590-pkm81fq1 201 40 intracellular intracellular JJ cord-013590-pkm81fq1 201 41 accumulation accumulation NN cord-013590-pkm81fq1 201 42 of of IN cord-013590-pkm81fq1 201 43 IPP IPP NNP cord-013590-pkm81fq1 201 44 . . . cord-013590-pkm81fq1 202 1 85 85 CD cord-013590-pkm81fq1 203 1 , , , cord-013590-pkm81fq1 203 2 86 86 CD cord-013590-pkm81fq1 203 3 Vγ9Vδ2 Vγ9Vδ2 NNS cord-013590-pkm81fq1 203 4 + + CC cord-013590-pkm81fq1 203 5 T t NN cord-013590-pkm81fq1 203 6 cells cell NNS cord-013590-pkm81fq1 203 7 can can MD cord-013590-pkm81fq1 203 8 therefore therefore RB cord-013590-pkm81fq1 203 9 be be VB cord-013590-pkm81fq1 203 10 expanded expand VBN cord-013590-pkm81fq1 203 11 for for IN cord-013590-pkm81fq1 203 12 cancer cancer NN cord-013590-pkm81fq1 203 13 immunotherapy immunotherapy NN cord-013590-pkm81fq1 203 14 by by IN cord-013590-pkm81fq1 203 15 administration administration NN cord-013590-pkm81fq1 203 16 of of IN cord-013590-pkm81fq1 203 17 these these DT cord-013590-pkm81fq1 203 18 aminobisphosphonate aminobisphosphonate NNP cord-013590-pkm81fq1 203 19 drugs drug NNS cord-013590-pkm81fq1 203 20 as as IN cord-013590-pkm81fq1 203 21 has have VBZ cord-013590-pkm81fq1 203 22 been be VBN cord-013590-pkm81fq1 203 23 reviewed review VBN cord-013590-pkm81fq1 203 24 by by IN cord-013590-pkm81fq1 203 25 Morita Morita NNP cord-013590-pkm81fq1 203 26 et et FW cord-013590-pkm81fq1 203 27 al al NNP cord-013590-pkm81fq1 203 28 . . . cord-013590-pkm81fq1 204 1 83 83 CD cord-013590-pkm81fq1 204 2 and and CC cord-013590-pkm81fq1 204 3 Legut Legut NNP cord-013590-pkm81fq1 204 4 et et FW cord-013590-pkm81fq1 204 5 al al NNP cord-013590-pkm81fq1 204 6 . . . cord-013590-pkm81fq1 204 7 87 87 CD cord-013590-pkm81fq1 205 1 The the DT cord-013590-pkm81fq1 205 2 recognition recognition NN cord-013590-pkm81fq1 205 3 of of IN cord-013590-pkm81fq1 205 4 ubiquitous ubiquitous JJ cord-013590-pkm81fq1 205 5 microbial microbial NN cord-013590-pkm81fq1 205 6 or or CC cord-013590-pkm81fq1 205 7 stress stress NN cord-013590-pkm81fq1 205 8 signals signal NNS cord-013590-pkm81fq1 205 9 by by IN cord-013590-pkm81fq1 205 10 γδ γδ IN cord-013590-pkm81fq1 205 11 TCRs TCRs NNP cord-013590-pkm81fq1 205 12 is be VBZ cord-013590-pkm81fq1 205 13 reminiscent reminiscent JJ cord-013590-pkm81fq1 205 14 of of IN cord-013590-pkm81fq1 205 15 the the DT cord-013590-pkm81fq1 205 16 PAMP pamp NN cord-013590-pkm81fq1 205 17 - - HYPH cord-013590-pkm81fq1 205 18 detection detection NN cord-013590-pkm81fq1 205 19 by by IN cord-013590-pkm81fq1 205 20 pattern pattern NN cord-013590-pkm81fq1 205 21 recognition recognition NN cord-013590-pkm81fq1 205 22 receptors receptor NNS cord-013590-pkm81fq1 205 23 , , , cord-013590-pkm81fq1 205 24 which which WDT cord-013590-pkm81fq1 205 25 is be VBZ cord-013590-pkm81fq1 205 26 supported support VBN cord-013590-pkm81fq1 205 27 by by IN cord-013590-pkm81fq1 205 28 the the DT cord-013590-pkm81fq1 205 29 semi semi JJ cord-013590-pkm81fq1 205 30 - - JJ cord-013590-pkm81fq1 205 31 invariant invariant JJ cord-013590-pkm81fq1 205 32 V v NN cord-013590-pkm81fq1 205 33 - - HYPH cord-013590-pkm81fq1 205 34 usage usage NN cord-013590-pkm81fq1 205 35 of of IN cord-013590-pkm81fq1 205 36 these these DT cord-013590-pkm81fq1 205 37 γδ γδ IN cord-013590-pkm81fq1 205 38 TCRs tcr NNS cord-013590-pkm81fq1 205 39 and and CC cord-013590-pkm81fq1 205 40 rather rather RB cord-013590-pkm81fq1 205 41 polyclonal polyclonal JJ cord-013590-pkm81fq1 205 42 expansions expansion NNS cord-013590-pkm81fq1 205 43 in in IN cord-013590-pkm81fq1 205 44 response response NN cord-013590-pkm81fq1 205 45 to to IN cord-013590-pkm81fq1 205 46 p p NN cord-013590-pkm81fq1 205 47 - - : cord-013590-pkm81fq1 205 48 Ags Ags NNP cord-013590-pkm81fq1 205 49 . . . cord-013590-pkm81fq1 205 50 88 88 CD cord-013590-pkm81fq1 206 1 Therefore therefore RB cord-013590-pkm81fq1 206 2 , , , cord-013590-pkm81fq1 206 3 Vγ9Vδ2 Vγ9Vδ2 VBZ cord-013590-pkm81fq1 206 4 + + CC cord-013590-pkm81fq1 206 5 TCR TCR NNP cord-013590-pkm81fq1 206 6 - - HYPH cord-013590-pkm81fq1 206 7 mediated mediate VBN cord-013590-pkm81fq1 206 8 recognition recognition NN cord-013590-pkm81fq1 206 9 of of IN cord-013590-pkm81fq1 206 10 p p NNP cord-013590-pkm81fq1 206 11 - - : cord-013590-pkm81fq1 206 12 Ags Ags NNP cord-013590-pkm81fq1 206 13 has have VBZ cord-013590-pkm81fq1 206 14 been be VBN cord-013590-pkm81fq1 206 15 termed term VBN cord-013590-pkm81fq1 206 16 innate innate JJ cord-013590-pkm81fq1 206 17 - - HYPH cord-013590-pkm81fq1 206 18 like like JJ cord-013590-pkm81fq1 206 19 . . . cord-013590-pkm81fq1 207 1 84 84 CD cord-013590-pkm81fq1 208 1 Despite despite IN cord-013590-pkm81fq1 208 2 the the DT cord-013590-pkm81fq1 208 3 requirement requirement NN cord-013590-pkm81fq1 208 4 for for IN cord-013590-pkm81fq1 208 5 p p NN cord-013590-pkm81fq1 208 6 - - : cord-013590-pkm81fq1 208 7 Ags Ags NNP cord-013590-pkm81fq1 208 8 for for IN cord-013590-pkm81fq1 208 9 the the DT cord-013590-pkm81fq1 208 10 activation activation NN cord-013590-pkm81fq1 208 11 of of IN cord-013590-pkm81fq1 208 12 Vγ9Vδ2 Vγ9Vδ2 NNS cord-013590-pkm81fq1 208 13 + + CC cord-013590-pkm81fq1 208 14 TCRs tcr NNS cord-013590-pkm81fq1 208 15 , , , cord-013590-pkm81fq1 208 16 these these DT cord-013590-pkm81fq1 208 17 small small JJ cord-013590-pkm81fq1 208 18 phosphorylated phosphorylated JJ cord-013590-pkm81fq1 208 19 moieties moiety NNS cord-013590-pkm81fq1 208 20 are be VBP cord-013590-pkm81fq1 208 21 not not RB cord-013590-pkm81fq1 208 22 the the DT cord-013590-pkm81fq1 208 23 cognate cognate JJ cord-013590-pkm81fq1 208 24 antigens antigen NNS cord-013590-pkm81fq1 208 25 binding bind VBG cord-013590-pkm81fq1 208 26 to to IN cord-013590-pkm81fq1 208 27 γδ γδ NNP cord-013590-pkm81fq1 208 28 TCRs tcr NNS cord-013590-pkm81fq1 208 29 and and CC cord-013590-pkm81fq1 208 30 cell cell NN cord-013590-pkm81fq1 208 31 to to IN cord-013590-pkm81fq1 208 32 cell cell NN cord-013590-pkm81fq1 208 33 contact contact NN cord-013590-pkm81fq1 208 34 is be VBZ cord-013590-pkm81fq1 208 35 necessary necessary JJ cord-013590-pkm81fq1 208 36 . . . cord-013590-pkm81fq1 209 1 89 89 CD cord-013590-pkm81fq1 210 1 Especially especially RB cord-013590-pkm81fq1 210 2 , , , cord-013590-pkm81fq1 210 3 the the DT cord-013590-pkm81fq1 210 4 protein protein NN cord-013590-pkm81fq1 210 5 butyrophilin butyrophilin NN cord-013590-pkm81fq1 210 6 3 3 CD cord-013590-pkm81fq1 210 7 A1 A1 NNP cord-013590-pkm81fq1 210 8 ( ( -LRB- cord-013590-pkm81fq1 210 9 BTN3A1 BTN3A1 NNP cord-013590-pkm81fq1 210 10 ) ) -RRB- cord-013590-pkm81fq1 210 11 has have VBZ cord-013590-pkm81fq1 210 12 been be VBN cord-013590-pkm81fq1 210 13 shown show VBN cord-013590-pkm81fq1 210 14 to to TO cord-013590-pkm81fq1 210 15 be be VB cord-013590-pkm81fq1 210 16 essential essential JJ cord-013590-pkm81fq1 210 17 for for IN cord-013590-pkm81fq1 210 18 γδ γδ NNP cord-013590-pkm81fq1 210 19 TCR TCR NNP cord-013590-pkm81fq1 210 20 - - HYPH cord-013590-pkm81fq1 210 21 mediated mediate VBN cord-013590-pkm81fq1 210 22 p p NN cord-013590-pkm81fq1 210 23 - - : cord-013590-pkm81fq1 210 24 Ag Ag NNP cord-013590-pkm81fq1 210 25 - - HYPH cord-013590-pkm81fq1 210 26 recognition recognition NN cord-013590-pkm81fq1 210 27 . . . cord-013590-pkm81fq1 211 1 90 90 CD cord-013590-pkm81fq1 211 2 , , , cord-013590-pkm81fq1 211 3 91 91 CD cord-013590-pkm81fq1 211 4 BTN3A1 BTN3A1 NNP cord-013590-pkm81fq1 211 5 belongs belong VBZ cord-013590-pkm81fq1 211 6 as as IN cord-013590-pkm81fq1 211 7 the the DT cord-013590-pkm81fq1 211 8 other other JJ cord-013590-pkm81fq1 211 9 butyrophilins butyrophilin NNS cord-013590-pkm81fq1 211 10 to to IN cord-013590-pkm81fq1 211 11 the the DT cord-013590-pkm81fq1 211 12 B7 B7 NNP cord-013590-pkm81fq1 211 13 receptor receptor NN cord-013590-pkm81fq1 211 14 family family NN cord-013590-pkm81fq1 211 15 - - HYPH cord-013590-pkm81fq1 211 16 like like JJ cord-013590-pkm81fq1 211 17 proteins protein NNS cord-013590-pkm81fq1 211 18 and and CC cord-013590-pkm81fq1 211 19 consists consist VBZ cord-013590-pkm81fq1 211 20 of of IN cord-013590-pkm81fq1 211 21 two two CD cord-013590-pkm81fq1 211 22 extracellular extracellular JJ cord-013590-pkm81fq1 211 23 Ig Ig NNP cord-013590-pkm81fq1 211 24 - - HYPH cord-013590-pkm81fq1 211 25 like like JJ cord-013590-pkm81fq1 211 26 domains domain NNS cord-013590-pkm81fq1 211 27 , , , cord-013590-pkm81fq1 211 28 transmembrane transmembrane NNP cord-013590-pkm81fq1 211 29 and and CC cord-013590-pkm81fq1 211 30 juxtamembrane juxtamembrane NNP cord-013590-pkm81fq1 211 31 domains domain NNS cord-013590-pkm81fq1 211 32 and and CC cord-013590-pkm81fq1 211 33 an an DT cord-013590-pkm81fq1 211 34 intracellular intracellular JJ cord-013590-pkm81fq1 211 35 B30.2 B30.2 NNP cord-013590-pkm81fq1 211 36 domain domain NN cord-013590-pkm81fq1 211 37 . . . cord-013590-pkm81fq1 212 1 92 92 CD cord-013590-pkm81fq1 213 1 After after IN cord-013590-pkm81fq1 213 2 the the DT cord-013590-pkm81fq1 213 3 discovery discovery NN cord-013590-pkm81fq1 213 4 of of IN cord-013590-pkm81fq1 213 5 BTN3A1 BTN3A1 NNP cord-013590-pkm81fq1 213 6 as as IN cord-013590-pkm81fq1 213 7 a a DT cord-013590-pkm81fq1 213 8 central central JJ cord-013590-pkm81fq1 213 9 mediator mediator NN cord-013590-pkm81fq1 213 10 of of IN cord-013590-pkm81fq1 213 11 p p NNP cord-013590-pkm81fq1 213 12 - - : cord-013590-pkm81fq1 213 13 Ag Ag NNP cord-013590-pkm81fq1 213 14 reactivity reactivity NN cord-013590-pkm81fq1 213 15 , , , cord-013590-pkm81fq1 213 16 two two CD cord-013590-pkm81fq1 213 17 different different JJ cord-013590-pkm81fq1 213 18 models model NNS cord-013590-pkm81fq1 213 19 of of IN cord-013590-pkm81fq1 213 20 interaction interaction NN cord-013590-pkm81fq1 213 21 with with IN cord-013590-pkm81fq1 213 22 p p NNP cord-013590-pkm81fq1 213 23 - - : cord-013590-pkm81fq1 213 24 Ags Ags NNP cord-013590-pkm81fq1 213 25 were be VBD cord-013590-pkm81fq1 213 26 proposed propose VBN cord-013590-pkm81fq1 213 27 . . . cord-013590-pkm81fq1 214 1 Vavassori Vavassori NNP cord-013590-pkm81fq1 214 2 et et FW cord-013590-pkm81fq1 214 3 al al NNP cord-013590-pkm81fq1 214 4 . . . cord-013590-pkm81fq1 215 1 93 93 CD cord-013590-pkm81fq1 215 2 first first RB cord-013590-pkm81fq1 215 3 showed show VBD cord-013590-pkm81fq1 215 4 evidence evidence NN cord-013590-pkm81fq1 215 5 for for IN cord-013590-pkm81fq1 215 6 an an DT cord-013590-pkm81fq1 215 7 antigen antigen NN cord-013590-pkm81fq1 215 8 presentation presentation NN cord-013590-pkm81fq1 215 9 by by IN cord-013590-pkm81fq1 215 10 BTN3A1 BTN3A1 NNP cord-013590-pkm81fq1 215 11 and and CC cord-013590-pkm81fq1 215 12 a a DT cord-013590-pkm81fq1 215 13 direct direct JJ cord-013590-pkm81fq1 215 14 interaction interaction NN cord-013590-pkm81fq1 215 15 between between IN cord-013590-pkm81fq1 215 16 p p NN cord-013590-pkm81fq1 215 17 - - : cord-013590-pkm81fq1 215 18 Ag Ag NNP cord-013590-pkm81fq1 215 19 presenting present VBG cord-013590-pkm81fq1 215 20 BTN3A1 BTN3A1 NNP cord-013590-pkm81fq1 215 21 and and CC cord-013590-pkm81fq1 215 22 the the DT cord-013590-pkm81fq1 215 23 Vγ9Vδ2 Vγ9Vδ2 NNS cord-013590-pkm81fq1 215 24 + + CC cord-013590-pkm81fq1 215 25 TCR TCR NNP cord-013590-pkm81fq1 215 26 . . . cord-013590-pkm81fq1 216 1 In in IN cord-013590-pkm81fq1 216 2 contrast contrast NN cord-013590-pkm81fq1 216 3 , , , cord-013590-pkm81fq1 216 4 Sandstrom Sandstrom NNP cord-013590-pkm81fq1 216 5 et et NNP cord-013590-pkm81fq1 216 6 al al NNP cord-013590-pkm81fq1 216 7 . . . cord-013590-pkm81fq1 217 1 94 94 CD cord-013590-pkm81fq1 217 2 made make VBD cord-013590-pkm81fq1 217 3 the the DT cord-013590-pkm81fq1 217 4 observation observation NN cord-013590-pkm81fq1 217 5 that that IN cord-013590-pkm81fq1 217 6 the the DT cord-013590-pkm81fq1 217 7 intracellular intracellular JJ cord-013590-pkm81fq1 217 8 B30.2 B30.2 NNP cord-013590-pkm81fq1 217 9 domain domain NN cord-013590-pkm81fq1 217 10 of of IN cord-013590-pkm81fq1 217 11 BTN3A1 BTN3A1 NNP cord-013590-pkm81fq1 217 12 binds bind VBZ cord-013590-pkm81fq1 217 13 the the DT cord-013590-pkm81fq1 217 14 p p NNP cord-013590-pkm81fq1 217 15 - - : cord-013590-pkm81fq1 217 16 Ags Ags NNP cord-013590-pkm81fq1 217 17 in in IN cord-013590-pkm81fq1 217 18 a a DT cord-013590-pkm81fq1 217 19 pocket pocket NN cord-013590-pkm81fq1 217 20 with with IN cord-013590-pkm81fq1 217 21 basic basic JJ cord-013590-pkm81fq1 217 22 residues residue NNS cord-013590-pkm81fq1 217 23 and and CC cord-013590-pkm81fq1 217 24 no no DT cord-013590-pkm81fq1 217 25 direct direct JJ cord-013590-pkm81fq1 217 26 interaction interaction NN cord-013590-pkm81fq1 217 27 between between IN cord-013590-pkm81fq1 217 28 the the DT cord-013590-pkm81fq1 217 29 extracellular extracellular JJ cord-013590-pkm81fq1 217 30 IgV igv NN cord-013590-pkm81fq1 217 31 - - HYPH cord-013590-pkm81fq1 217 32 domain domain NN cord-013590-pkm81fq1 217 33 of of IN cord-013590-pkm81fq1 217 34 BTN3A1 BTN3A1 NNP cord-013590-pkm81fq1 217 35 and and CC cord-013590-pkm81fq1 217 36 the the DT cord-013590-pkm81fq1 217 37 Vγ9Vδ2 vγ9vδ2 NN cord-013590-pkm81fq1 218 1 + + CC cord-013590-pkm81fq1 218 2 TCR TCR NNP cord-013590-pkm81fq1 218 3 was be VBD cord-013590-pkm81fq1 218 4 detected detect VBN cord-013590-pkm81fq1 218 5 . . . cord-013590-pkm81fq1 219 1 Subsequent subsequent JJ cord-013590-pkm81fq1 219 2 mutagenesis mutagenesis NN cord-013590-pkm81fq1 219 3 experiments experiment NNS cord-013590-pkm81fq1 219 4 with with IN cord-013590-pkm81fq1 219 5 BTN3A1 BTN3A1 NNP cord-013590-pkm81fq1 219 6 intra intra NNP cord-013590-pkm81fq1 219 7 - - : cord-013590-pkm81fq1 219 8 and and CC cord-013590-pkm81fq1 219 9 extracellular extracellular JJ cord-013590-pkm81fq1 219 10 domains domain NNS cord-013590-pkm81fq1 219 11 revealed reveal VBD cord-013590-pkm81fq1 219 12 that that IN cord-013590-pkm81fq1 219 13 the the DT cord-013590-pkm81fq1 219 14 second second JJ cord-013590-pkm81fq1 219 15 model model NN cord-013590-pkm81fq1 219 16 of of IN cord-013590-pkm81fq1 219 17 intracellular intracellular JJ cord-013590-pkm81fq1 219 18 p p NN cord-013590-pkm81fq1 219 19 - - : cord-013590-pkm81fq1 219 20 Ag Ag NNP cord-013590-pkm81fq1 219 21 binding binding NN cord-013590-pkm81fq1 219 22 held hold VBN cord-013590-pkm81fq1 219 23 true true JJ cord-013590-pkm81fq1 219 24 . . . cord-013590-pkm81fq1 220 1 95 95 CD cord-013590-pkm81fq1 221 1 Moreover moreover RB cord-013590-pkm81fq1 221 2 , , , cord-013590-pkm81fq1 221 3 rodent rodent NN cord-013590-pkm81fq1 221 4 cells cell NNS cord-013590-pkm81fq1 221 5 expressing express VBG cord-013590-pkm81fq1 221 6 human human JJ cord-013590-pkm81fq1 221 7 BTN3A1 BTN3A1 NNP cord-013590-pkm81fq1 221 8 are be VBP cord-013590-pkm81fq1 221 9 not not RB cord-013590-pkm81fq1 221 10 able able JJ cord-013590-pkm81fq1 221 11 to to TO cord-013590-pkm81fq1 221 12 stimulate stimulate VB cord-013590-pkm81fq1 221 13 Vγ9Vδ2 Vγ9Vδ2 NNS cord-013590-pkm81fq1 221 14 + + CC cord-013590-pkm81fq1 221 15 TCRs tcr NNS cord-013590-pkm81fq1 221 16 upon upon IN cord-013590-pkm81fq1 221 17 p p NN cord-013590-pkm81fq1 221 18 - - : cord-013590-pkm81fq1 221 19 Ag Ag NNP cord-013590-pkm81fq1 221 20 exposure exposure NN cord-013590-pkm81fq1 221 21 indicating indicate VBG cord-013590-pkm81fq1 221 22 that that IN cord-013590-pkm81fq1 221 23 other other JJ cord-013590-pkm81fq1 221 24 mechanisms mechanism NNS cord-013590-pkm81fq1 221 25 and and CC cord-013590-pkm81fq1 221 26 molecules molecule NNS cord-013590-pkm81fq1 221 27 are be VBP cord-013590-pkm81fq1 221 28 probably probably RB cord-013590-pkm81fq1 221 29 involved involved JJ cord-013590-pkm81fq1 221 30 . . . cord-013590-pkm81fq1 222 1 94 94 CD cord-013590-pkm81fq1 223 1 Thus thus RB cord-013590-pkm81fq1 223 2 , , , cord-013590-pkm81fq1 223 3 the the DT cord-013590-pkm81fq1 223 4 current current JJ cord-013590-pkm81fq1 223 5 concept concept NN cord-013590-pkm81fq1 223 6 of of IN cord-013590-pkm81fq1 223 7 BTN3A1-mediated btn3a1-mediated CD cord-013590-pkm81fq1 223 8 activation activation NN cord-013590-pkm81fq1 223 9 of of IN cord-013590-pkm81fq1 223 10 Vγ9Vδ2 Vγ9Vδ2 NNS cord-013590-pkm81fq1 223 11 + + CC cord-013590-pkm81fq1 223 12 TCRs TCRs NNP cord-013590-pkm81fq1 223 13 implies imply VBZ cord-013590-pkm81fq1 223 14 that that IN cord-013590-pkm81fq1 223 15 intracellular intracellular JJ cord-013590-pkm81fq1 223 16 p p NN cord-013590-pkm81fq1 223 17 - - : cord-013590-pkm81fq1 223 18 Ag Ag NNP cord-013590-pkm81fq1 223 19 binding bind VBG cord-013590-pkm81fq1 223 20 to to IN cord-013590-pkm81fq1 223 21 the the DT cord-013590-pkm81fq1 223 22 B30.2 B30.2 NNP cord-013590-pkm81fq1 223 23 domain domain NN cord-013590-pkm81fq1 223 24 leads lead VBZ cord-013590-pkm81fq1 223 25 to to TO cord-013590-pkm81fq1 223 26 conformational conformational VB cord-013590-pkm81fq1 223 27 changes change NNS cord-013590-pkm81fq1 223 28 that that WDT cord-013590-pkm81fq1 223 29 translate translate VBP cord-013590-pkm81fq1 223 30 to to IN cord-013590-pkm81fq1 223 31 the the DT cord-013590-pkm81fq1 223 32 extracellular extracellular JJ cord-013590-pkm81fq1 223 33 domain domain NN cord-013590-pkm81fq1 223 34 of of IN cord-013590-pkm81fq1 223 35 BTN3A1 BTN3A1 NNP cord-013590-pkm81fq1 223 36 in in IN cord-013590-pkm81fq1 223 37 order order NN cord-013590-pkm81fq1 223 38 to to TO cord-013590-pkm81fq1 223 39 be be VB cord-013590-pkm81fq1 223 40 sensed sense VBN cord-013590-pkm81fq1 223 41 indirectly indirectly RB cord-013590-pkm81fq1 223 42 by by IN cord-013590-pkm81fq1 223 43 Vγ9Vδ2 Vγ9Vδ2 NNS cord-013590-pkm81fq1 223 44 + + CC cord-013590-pkm81fq1 223 45 TCRs tcr NNS cord-013590-pkm81fq1 223 46 . . . cord-013590-pkm81fq1 224 1 Inline inline VB cord-013590-pkm81fq1 224 2 with with IN cord-013590-pkm81fq1 224 3 this this DT cord-013590-pkm81fq1 224 4 hypothesis hypothesis NN cord-013590-pkm81fq1 224 5 , , , cord-013590-pkm81fq1 224 6 NMR NMR NNP cord-013590-pkm81fq1 224 7 - - HYPH cord-013590-pkm81fq1 224 8 studies study NNS cord-013590-pkm81fq1 224 9 of of IN cord-013590-pkm81fq1 224 10 the the DT cord-013590-pkm81fq1 224 11 B30.2 B30.2 NNP cord-013590-pkm81fq1 224 12 domain domain NN cord-013590-pkm81fq1 224 13 and and CC cord-013590-pkm81fq1 224 14 the the DT cord-013590-pkm81fq1 224 15 juxtamembrane juxtamembrane NNP cord-013590-pkm81fq1 224 16 domain domain NN cord-013590-pkm81fq1 224 17 of of IN cord-013590-pkm81fq1 224 18 BTN3A1 BTN3A1 NNP cord-013590-pkm81fq1 224 19 revealed reveal VBD cord-013590-pkm81fq1 224 20 conformational conformational JJ cord-013590-pkm81fq1 224 21 changes change NNS cord-013590-pkm81fq1 224 22 upon upon IN cord-013590-pkm81fq1 224 23 p p NN cord-013590-pkm81fq1 224 24 - - : cord-013590-pkm81fq1 224 25 Ag Ag NNP cord-013590-pkm81fq1 224 26 binding binding NN cord-013590-pkm81fq1 224 27 . . . cord-013590-pkm81fq1 225 1 [ [ -LRB- cord-013590-pkm81fq1 225 2 96 96 CD cord-013590-pkm81fq1 225 3 ] ] -RRB- cord-013590-pkm81fq1 225 4 [ [ -LRB- cord-013590-pkm81fq1 225 5 97 97 CD cord-013590-pkm81fq1 225 6 ] ] -RRB- cord-013590-pkm81fq1 226 1 [ [ -LRB- cord-013590-pkm81fq1 226 2 98 98 CD cord-013590-pkm81fq1 226 3 ] ] -RRB- cord-013590-pkm81fq1 227 1 Furthermore furthermore RB cord-013590-pkm81fq1 227 2 , , , cord-013590-pkm81fq1 227 3 the the DT cord-013590-pkm81fq1 227 4 cytoskeletal cytoskeletal JJ cord-013590-pkm81fq1 227 5 adaptor adaptor NN cord-013590-pkm81fq1 227 6 protein protein NN cord-013590-pkm81fq1 227 7 periplakin periplakin NNP cord-013590-pkm81fq1 227 8 as as RB cord-013590-pkm81fq1 227 9 well well RB cord-013590-pkm81fq1 227 10 as as IN cord-013590-pkm81fq1 227 11 the the DT cord-013590-pkm81fq1 227 12 GTPase GTPase NNP cord-013590-pkm81fq1 227 13 RhoB RhoB NNP cord-013590-pkm81fq1 227 14 were be VBD cord-013590-pkm81fq1 227 15 reported report VBN cord-013590-pkm81fq1 227 16 to to TO cord-013590-pkm81fq1 227 17 interact interact VB cord-013590-pkm81fq1 227 18 with with IN cord-013590-pkm81fq1 227 19 the the DT cord-013590-pkm81fq1 227 20 B30.2 B30.2 NNP cord-013590-pkm81fq1 227 21 domain domain NN cord-013590-pkm81fq1 227 22 and and CC cord-013590-pkm81fq1 227 23 thereby thereby RB cord-013590-pkm81fq1 227 24 assist assist VB cord-013590-pkm81fq1 227 25 to to TO cord-013590-pkm81fq1 227 26 organize organize VB cord-013590-pkm81fq1 227 27 BTN3A1 BTN3A1 NNP cord-013590-pkm81fq1 227 28 membrane membrane NN cord-013590-pkm81fq1 227 29 organization organization NN cord-013590-pkm81fq1 227 30 influencing influence VBG cord-013590-pkm81fq1 227 31 Vγ9Vδ2 Vγ9Vδ2 NNP cord-013590-pkm81fq1 227 32 + + CC cord-013590-pkm81fq1 227 33 TCR TCR NNP cord-013590-pkm81fq1 227 34 activation activation NN cord-013590-pkm81fq1 227 35 . . . cord-013590-pkm81fq1 228 1 99 99 CD cord-013590-pkm81fq1 228 2 , , , cord-013590-pkm81fq1 228 3 100 100 CD cord-013590-pkm81fq1 229 1 However however RB cord-013590-pkm81fq1 229 2 , , , cord-013590-pkm81fq1 229 3 BTN3A1 BTN3A1 NNP cord-013590-pkm81fq1 229 4 alone alone JJ cord-013590-pkm81fq1 229 5 is be VBZ cord-013590-pkm81fq1 229 6 not not RB cord-013590-pkm81fq1 229 7 sufficient sufficient JJ cord-013590-pkm81fq1 229 8 for for IN cord-013590-pkm81fq1 229 9 p p NN cord-013590-pkm81fq1 229 10 - - : cord-013590-pkm81fq1 229 11 Ag Ag NNP cord-013590-pkm81fq1 229 12 recognition recognition NN cord-013590-pkm81fq1 229 13 by by IN cord-013590-pkm81fq1 229 14 Vγ9Vδ2 Vγ9Vδ2 NNS cord-013590-pkm81fq1 229 15 + + CC cord-013590-pkm81fq1 229 16 TCRs tcr NNS cord-013590-pkm81fq1 229 17 as as IN cord-013590-pkm81fq1 229 18 the the DT cord-013590-pkm81fq1 229 19 BTN3A btn3a CD cord-013590-pkm81fq1 229 20 isoforms isoform NNS cord-013590-pkm81fq1 229 21 BTN3A2 BTN3A2 NNP cord-013590-pkm81fq1 229 22 and and CC cord-013590-pkm81fq1 229 23 BTN3A3 BTN3A3 NNP cord-013590-pkm81fq1 229 24 were be VBD cord-013590-pkm81fq1 229 25 shown show VBN cord-013590-pkm81fq1 229 26 to to TO cord-013590-pkm81fq1 229 27 be be VB cord-013590-pkm81fq1 229 28 required require VBN cord-013590-pkm81fq1 229 29 by by IN cord-013590-pkm81fq1 229 30 the the DT cord-013590-pkm81fq1 229 31 use use NN cord-013590-pkm81fq1 229 32 of of IN cord-013590-pkm81fq1 229 33 knock knock VB cord-013590-pkm81fq1 229 34 down down RP cord-013590-pkm81fq1 229 35 and and CC cord-013590-pkm81fq1 229 36 knockout knockout NN cord-013590-pkm81fq1 229 37 cell cell NN cord-013590-pkm81fq1 229 38 lines line NNS cord-013590-pkm81fq1 229 39 . . . cord-013590-pkm81fq1 230 1 99 99 CD cord-013590-pkm81fq1 230 2 , , , cord-013590-pkm81fq1 230 3 101 101 CD cord-013590-pkm81fq1 231 1 In in IN cord-013590-pkm81fq1 231 2 contrast contrast NN cord-013590-pkm81fq1 231 3 to to IN cord-013590-pkm81fq1 231 4 the the DT cord-013590-pkm81fq1 231 5 observation observation NN cord-013590-pkm81fq1 231 6 of of IN cord-013590-pkm81fq1 231 7 BTN3A1 BTN3A1 NNP cord-013590-pkm81fq1 231 8 homodimers homodimer NNS cord-013590-pkm81fq1 231 9 , , , cord-013590-pkm81fq1 231 10 BTN3A1 BTN3A1 NNP cord-013590-pkm81fq1 231 11 and and CC cord-013590-pkm81fq1 231 12 BTN3A2 BTN3A2 NNP cord-013590-pkm81fq1 231 13 seem seem VBP cord-013590-pkm81fq1 231 14 also also RB cord-013590-pkm81fq1 231 15 to to TO cord-013590-pkm81fq1 231 16 be be VB cord-013590-pkm81fq1 231 17 able able JJ cord-013590-pkm81fq1 231 18 to to TO cord-013590-pkm81fq1 231 19 form form VB cord-013590-pkm81fq1 231 20 heterodimers heterodimer NNS cord-013590-pkm81fq1 231 21 , , , cord-013590-pkm81fq1 231 22 which which WDT cord-013590-pkm81fq1 231 23 enable enable VBP cord-013590-pkm81fq1 231 24 the the DT cord-013590-pkm81fq1 231 25 correct correct JJ cord-013590-pkm81fq1 231 26 BTN3A1 BTN3A1 NNP cord-013590-pkm81fq1 231 27 localization localization NN cord-013590-pkm81fq1 231 28 to to IN cord-013590-pkm81fq1 231 29 the the DT cord-013590-pkm81fq1 231 30 cell cell NN cord-013590-pkm81fq1 231 31 membrane membrane NN cord-013590-pkm81fq1 231 32 and and CC cord-013590-pkm81fq1 231 33 complete complete JJ cord-013590-pkm81fq1 231 34 functionality functionality NN cord-013590-pkm81fq1 231 35 in in IN cord-013590-pkm81fq1 231 36 terms term NNS cord-013590-pkm81fq1 231 37 of of IN cord-013590-pkm81fq1 231 38 p p NN cord-013590-pkm81fq1 231 39 - - : cord-013590-pkm81fq1 231 40 Ag Ag NNP cord-013590-pkm81fq1 231 41 reactivity reactivity NN cord-013590-pkm81fq1 231 42 . . . cord-013590-pkm81fq1 232 1 Interestingly interestingly RB cord-013590-pkm81fq1 232 2 , , , cord-013590-pkm81fq1 232 3 expression expression NN cord-013590-pkm81fq1 232 4 of of IN cord-013590-pkm81fq1 232 5 BTN3A1 BTN3A1 NNP cord-013590-pkm81fq1 232 6 alone alone RB cord-013590-pkm81fq1 232 7 can can MD cord-013590-pkm81fq1 232 8 lead lead VB cord-013590-pkm81fq1 232 9 to to IN cord-013590-pkm81fq1 232 10 Vγ9Vδ2 vγ9vδ2 NN cord-013590-pkm81fq1 232 11 + + CC cord-013590-pkm81fq1 232 12 TCR TCR NNP cord-013590-pkm81fq1 232 13 activation activation NN cord-013590-pkm81fq1 232 14 in in IN cord-013590-pkm81fq1 232 15 response response NN cord-013590-pkm81fq1 232 16 to to IN cord-013590-pkm81fq1 232 17 p p NN cord-013590-pkm81fq1 232 18 - - : cord-013590-pkm81fq1 232 19 Ag Ag NNP cord-013590-pkm81fq1 232 20 , , , cord-013590-pkm81fq1 232 21 albeit albeit IN cord-013590-pkm81fq1 232 22 with with IN cord-013590-pkm81fq1 232 23 much much RB cord-013590-pkm81fq1 232 24 lower low JJR cord-013590-pkm81fq1 232 25 efficiency efficiency NN cord-013590-pkm81fq1 232 26 . . . cord-013590-pkm81fq1 233 1 To to TO cord-013590-pkm81fq1 233 2 which which WDT cord-013590-pkm81fq1 233 3 extent extent NN cord-013590-pkm81fq1 233 4 BTN3A btn3a JJ cord-013590-pkm81fq1 233 5 homo homo NN cord-013590-pkm81fq1 233 6 - - HYPH cord-013590-pkm81fq1 233 7 or or CC cord-013590-pkm81fq1 233 8 heterodimers heterodimer NNS cord-013590-pkm81fq1 233 9 play play VBP cord-013590-pkm81fq1 233 10 important important JJ cord-013590-pkm81fq1 233 11 functions function NNS cord-013590-pkm81fq1 233 12 in in IN cord-013590-pkm81fq1 233 13 p p NN cord-013590-pkm81fq1 233 14 - - : cord-013590-pkm81fq1 233 15 Ag Ag NNP cord-013590-pkm81fq1 233 16 recognition recognition NN cord-013590-pkm81fq1 233 17 by by IN cord-013590-pkm81fq1 233 18 Vγ9Vδ2 Vγ9Vδ2 NNS cord-013590-pkm81fq1 233 19 + + CC cord-013590-pkm81fq1 233 20 TCRs tcr NNS cord-013590-pkm81fq1 233 21 or or CC cord-013590-pkm81fq1 233 22 whether whether IN cord-013590-pkm81fq1 233 23 interconversion interconversion NN cord-013590-pkm81fq1 233 24 between between IN cord-013590-pkm81fq1 233 25 both both DT cord-013590-pkm81fq1 233 26 structural structural JJ cord-013590-pkm81fq1 233 27 arrangements arrangement NNS cord-013590-pkm81fq1 233 28 can can MD cord-013590-pkm81fq1 233 29 occur occur VB cord-013590-pkm81fq1 233 30 is be VBZ cord-013590-pkm81fq1 233 31 still still RB cord-013590-pkm81fq1 233 32 to to TO cord-013590-pkm81fq1 233 33 be be VB cord-013590-pkm81fq1 233 34 elucidated elucidate VBN cord-013590-pkm81fq1 233 35 . . . cord-013590-pkm81fq1 234 1 Although although IN cord-013590-pkm81fq1 234 2 the the DT cord-013590-pkm81fq1 234 3 evidence evidence NN cord-013590-pkm81fq1 234 4 for for IN cord-013590-pkm81fq1 234 5 BTN3A1 BTN3A1 NNP cord-013590-pkm81fq1 234 6 as as IN cord-013590-pkm81fq1 234 7 the the DT cord-013590-pkm81fq1 234 8 p p NNP cord-013590-pkm81fq1 234 9 - - HYPH cord-013590-pkm81fq1 234 10 Ag Ag NNP cord-013590-pkm81fq1 234 11 sensing sensing NN cord-013590-pkm81fq1 234 12 molecule molecule NN cord-013590-pkm81fq1 234 13 and and CC cord-013590-pkm81fq1 234 14 its -PRON- PRP$ cord-013590-pkm81fq1 234 15 influence influence NN cord-013590-pkm81fq1 234 16 on on IN cord-013590-pkm81fq1 234 17 Vγ9Vδ2 Vγ9Vδ2 NNS cord-013590-pkm81fq1 235 1 + + CC cord-013590-pkm81fq1 235 2 TCR TCR NNP cord-013590-pkm81fq1 235 3 activation activation NN cord-013590-pkm81fq1 235 4 is be VBZ cord-013590-pkm81fq1 235 5 compelling compelling JJ cord-013590-pkm81fq1 235 6 , , , cord-013590-pkm81fq1 235 7 no no DT cord-013590-pkm81fq1 235 8 direct direct JJ cord-013590-pkm81fq1 235 9 interaction interaction NN cord-013590-pkm81fq1 235 10 with with IN cord-013590-pkm81fq1 235 11 the the DT cord-013590-pkm81fq1 235 12 γδ γδ NN cord-013590-pkm81fq1 236 1 TCR TCR NNP cord-013590-pkm81fq1 236 2 has have VBZ cord-013590-pkm81fq1 236 3 been be VBN cord-013590-pkm81fq1 236 4 established establish VBN cord-013590-pkm81fq1 236 5 so so RB cord-013590-pkm81fq1 236 6 far far RB cord-013590-pkm81fq1 236 7 . . . cord-013590-pkm81fq1 237 1 Rodent rodent NN cord-013590-pkm81fq1 237 2 cell cell NN cord-013590-pkm81fq1 237 3 lines line NNS cord-013590-pkm81fq1 237 4 expressing express VBG cord-013590-pkm81fq1 237 5 transgenic transgenic JJ cord-013590-pkm81fq1 237 6 human human NN cord-013590-pkm81fq1 237 7 BTN3A1 BTN3A1 NNP cord-013590-pkm81fq1 237 8 were be VBD cord-013590-pkm81fq1 237 9 shown show VBN cord-013590-pkm81fq1 237 10 to to TO cord-013590-pkm81fq1 237 11 require require VB cord-013590-pkm81fq1 237 12 human human JJ cord-013590-pkm81fq1 237 13 chromosome chromosome NN cord-013590-pkm81fq1 237 14 6 6 CD cord-013590-pkm81fq1 237 15 for for IN cord-013590-pkm81fq1 237 16 inducing induce VBG cord-013590-pkm81fq1 237 17 functional functional JJ cord-013590-pkm81fq1 237 18 p p NN cord-013590-pkm81fq1 237 19 - - : cord-013590-pkm81fq1 237 20 Ag Ag NNP cord-013590-pkm81fq1 237 21 reactivity reactivity NN cord-013590-pkm81fq1 237 22 in in IN cord-013590-pkm81fq1 237 23 Vγ9Vδ2 Vγ9Vδ2 NNS cord-013590-pkm81fq1 237 24 + + CC cord-013590-pkm81fq1 237 25 TCRs tcr NNS cord-013590-pkm81fq1 237 26 . . . cord-013590-pkm81fq1 238 1 102 102 CD cord-013590-pkm81fq1 239 1 Hence hence RB cord-013590-pkm81fq1 239 2 , , , cord-013590-pkm81fq1 239 3 another another DT cord-013590-pkm81fq1 239 4 component component NN cord-013590-pkm81fq1 239 5 encoded encode VBN cord-013590-pkm81fq1 239 6 on on IN cord-013590-pkm81fq1 239 7 this this DT cord-013590-pkm81fq1 239 8 chromosome chromosome NN cord-013590-pkm81fq1 239 9 appeared appear VBD cord-013590-pkm81fq1 239 10 to to TO cord-013590-pkm81fq1 239 11 be be VB cord-013590-pkm81fq1 239 12 essential essential JJ cord-013590-pkm81fq1 239 13 to to TO cord-013590-pkm81fq1 239 14 induce induce VB cord-013590-pkm81fq1 239 15 p p NN cord-013590-pkm81fq1 239 16 - - : cord-013590-pkm81fq1 239 17 Ag Ag NNP cord-013590-pkm81fq1 239 18 responses response NNS cord-013590-pkm81fq1 239 19 . . . cord-013590-pkm81fq1 240 1 Recently recently RB cord-013590-pkm81fq1 240 2 , , , cord-013590-pkm81fq1 240 3 BTN2A1 BTN2A1 NNP cord-013590-pkm81fq1 240 4 has have VBZ cord-013590-pkm81fq1 240 5 been be VBN cord-013590-pkm81fq1 240 6 identified identify VBN cord-013590-pkm81fq1 240 7 by by IN cord-013590-pkm81fq1 240 8 two two CD cord-013590-pkm81fq1 240 9 different different JJ cord-013590-pkm81fq1 240 10 approaches approach NNS cord-013590-pkm81fq1 240 11 to to TO cord-013590-pkm81fq1 240 12 be be VB cord-013590-pkm81fq1 240 13 this this DT cord-013590-pkm81fq1 240 14 enigmatic enigmatic JJ cord-013590-pkm81fq1 240 15 " " `` cord-013590-pkm81fq1 240 16 factor factor NN cord-013590-pkm81fq1 240 17 X x NN cord-013590-pkm81fq1 240 18 " " '' cord-013590-pkm81fq1 240 19 and and CC cord-013590-pkm81fq1 240 20 to to TO cord-013590-pkm81fq1 240 21 be be VB cord-013590-pkm81fq1 240 22 a a DT cord-013590-pkm81fq1 240 23 direct direct JJ cord-013590-pkm81fq1 240 24 ligand ligand NN cord-013590-pkm81fq1 240 25 for for IN cord-013590-pkm81fq1 240 26 Vγ9Vδ2 Vγ9Vδ2 NNS cord-013590-pkm81fq1 240 27 + + CC cord-013590-pkm81fq1 240 28 TCRs tcr NNS cord-013590-pkm81fq1 240 29 . . . cord-013590-pkm81fq1 241 1 Rigau Rigau NNP cord-013590-pkm81fq1 241 2 et et NNP cord-013590-pkm81fq1 241 3 al al NNP cord-013590-pkm81fq1 241 4 . . . cord-013590-pkm81fq1 242 1 103 103 CD cord-013590-pkm81fq1 242 2 employed employ VBN cord-013590-pkm81fq1 242 3 tetramerized tetramerize VBN cord-013590-pkm81fq1 242 4 soluble soluble JJ cord-013590-pkm81fq1 242 5 TCR TCR NNP cord-013590-pkm81fq1 242 6 staining staining NN cord-013590-pkm81fq1 242 7 of of IN cord-013590-pkm81fq1 242 8 target target NN cord-013590-pkm81fq1 242 9 cells cell NNS cord-013590-pkm81fq1 242 10 and and CC cord-013590-pkm81fq1 242 11 a a DT cord-013590-pkm81fq1 242 12 genome genome NN cord-013590-pkm81fq1 242 13 - - HYPH cord-013590-pkm81fq1 242 14 wide wide JJ cord-013590-pkm81fq1 242 15 CRISPR CRISPR NNP cord-013590-pkm81fq1 242 16 screening screening NN cord-013590-pkm81fq1 242 17 to to TO cord-013590-pkm81fq1 242 18 identify identify VB cord-013590-pkm81fq1 242 19 candidates candidate NNS cord-013590-pkm81fq1 242 20 for for IN cord-013590-pkm81fq1 242 21 Vγ9Vδ2 Vγ9Vδ2 NNS cord-013590-pkm81fq1 242 22 + + CC cord-013590-pkm81fq1 242 23 TCR TCR NNP cord-013590-pkm81fq1 242 24 ligands ligand NNS cord-013590-pkm81fq1 242 25 . . . cord-013590-pkm81fq1 243 1 At at IN cord-013590-pkm81fq1 243 2 the the DT cord-013590-pkm81fq1 243 3 same same JJ cord-013590-pkm81fq1 243 4 time time NN cord-013590-pkm81fq1 243 5 , , , cord-013590-pkm81fq1 243 6 Karunakaran Karunakaran NNP cord-013590-pkm81fq1 243 7 et et NNP cord-013590-pkm81fq1 243 8 al al NNP cord-013590-pkm81fq1 243 9 . . . cord-013590-pkm81fq1 244 1 104 104 CD cord-013590-pkm81fq1 244 2 generated generate VBD cord-013590-pkm81fq1 244 3 radiation radiation NN cord-013590-pkm81fq1 244 4 hybrids hybrid NNS cord-013590-pkm81fq1 244 5 of of IN cord-013590-pkm81fq1 244 6 Chinese chinese JJ cord-013590-pkm81fq1 244 7 Hamster Hamster NNP cord-013590-pkm81fq1 244 8 Ovarian Ovarian NNP cord-013590-pkm81fq1 244 9 ( ( -LRB- cord-013590-pkm81fq1 244 10 CHO CHO NNP cord-013590-pkm81fq1 244 11 ) ) -RRB- cord-013590-pkm81fq1 244 12 cells cell NNS cord-013590-pkm81fq1 244 13 containing contain VBG cord-013590-pkm81fq1 244 14 human human JJ cord-013590-pkm81fq1 244 15 chromosome chromosome NN cord-013590-pkm81fq1 244 16 6 6 CD cord-013590-pkm81fq1 244 17 and and CC cord-013590-pkm81fq1 244 18 screening screening NN cord-013590-pkm81fq1 244 19 for for IN cord-013590-pkm81fq1 244 20 abrogation abrogation NN cord-013590-pkm81fq1 244 21 of of IN cord-013590-pkm81fq1 244 22 p p NN cord-013590-pkm81fq1 244 23 - - : cord-013590-pkm81fq1 244 24 Ag Ag NNP cord-013590-pkm81fq1 244 25 reactivity reactivity NN cord-013590-pkm81fq1 244 26 led lead VBD cord-013590-pkm81fq1 244 27 to to IN cord-013590-pkm81fq1 244 28 the the DT cord-013590-pkm81fq1 244 29 identification identification NN cord-013590-pkm81fq1 244 30 of of IN cord-013590-pkm81fq1 244 31 the the DT cord-013590-pkm81fq1 244 32 gene gene NN cord-013590-pkm81fq1 244 33 encoding encode VBG cord-013590-pkm81fq1 244 34 BTN2A1 BTN2A1 NNP cord-013590-pkm81fq1 244 35 . . . cord-013590-pkm81fq1 245 1 Both both DT cord-013590-pkm81fq1 245 2 publications publication NNS cord-013590-pkm81fq1 245 3 suggested suggest VBD cord-013590-pkm81fq1 245 4 binding bind VBG cord-013590-pkm81fq1 245 5 of of IN cord-013590-pkm81fq1 245 6 the the DT cord-013590-pkm81fq1 245 7 Ligand Ligand NNP cord-013590-pkm81fq1 245 8 recognition recognition NN cord-013590-pkm81fq1 245 9 by by IN cord-013590-pkm81fq1 245 10 the the DT cord-013590-pkm81fq1 245 11 γδ γδ NNP cord-013590-pkm81fq1 245 12 TCR TCR NNP cord-013590-pkm81fq1 245 13 and and CC cord-013590-pkm81fq1 245 14 discrimination discrimination NN cord-013590-pkm81fq1 245 15 between between IN cord-013590-pkm81fq1 245 16 homeostasis homeostasis NN cord-013590-pkm81fq1 245 17 . . . cord-013590-pkm81fq1 245 18 . . . cord-013590-pkm81fq1 245 19 . . . cord-013590-pkm81fq1 246 1 Vγ9-chain Vγ9-chain NNP cord-013590-pkm81fq1 247 1 to to IN cord-013590-pkm81fq1 247 2 BTN2A1 BTN2A1 NNP cord-013590-pkm81fq1 247 3 via via IN cord-013590-pkm81fq1 247 4 germline germline NN cord-013590-pkm81fq1 247 5 - - HYPH cord-013590-pkm81fq1 247 6 encoded encode VBN cord-013590-pkm81fq1 247 7 regions region NNS cord-013590-pkm81fq1 247 8 and and CC cord-013590-pkm81fq1 247 9 without without IN cord-013590-pkm81fq1 247 10 major major JJ cord-013590-pkm81fq1 247 11 involvement involvement NN cord-013590-pkm81fq1 247 12 of of IN cord-013590-pkm81fq1 247 13 the the DT cord-013590-pkm81fq1 247 14 CDRs cdr NNS cord-013590-pkm81fq1 247 15 with with IN cord-013590-pkm81fq1 247 16 an an DT cord-013590-pkm81fq1 247 17 affinity affinity NN cord-013590-pkm81fq1 247 18 of of IN cord-013590-pkm81fq1 247 19 around around RB cord-013590-pkm81fq1 247 20 45 45 CD cord-013590-pkm81fq1 247 21 - - SYM cord-013590-pkm81fq1 247 22 50 50 CD cord-013590-pkm81fq1 247 23 µM. µm. JJ cord-013590-pkm81fq1 247 24 BTN2A1 BTN2A1 NNP cord-013590-pkm81fq1 247 25 itself -PRON- PRP cord-013590-pkm81fq1 247 26 seems seem VBZ cord-013590-pkm81fq1 247 27 to to TO cord-013590-pkm81fq1 247 28 form form VB cord-013590-pkm81fq1 247 29 homodimers homodimer NNS cord-013590-pkm81fq1 247 30 linked link VBN cord-013590-pkm81fq1 247 31 by by IN cord-013590-pkm81fq1 247 32 disulfide disulfide JJ cord-013590-pkm81fq1 247 33 bridges bridge NNS cord-013590-pkm81fq1 247 34 and and CC cord-013590-pkm81fq1 247 35 it -PRON- PRP cord-013590-pkm81fq1 247 36 associates associate VBZ cord-013590-pkm81fq1 247 37 with with IN cord-013590-pkm81fq1 247 38 BTN3A1 BTN3A1 NNP cord-013590-pkm81fq1 248 1 on on IN cord-013590-pkm81fq1 248 2 the the DT cord-013590-pkm81fq1 248 3 cell cell NN cord-013590-pkm81fq1 248 4 surface surface NN cord-013590-pkm81fq1 248 5 as as IN cord-013590-pkm81fq1 248 6 has have VBZ cord-013590-pkm81fq1 248 7 been be VBN cord-013590-pkm81fq1 248 8 shown show VBN cord-013590-pkm81fq1 248 9 by by IN cord-013590-pkm81fq1 248 10 co co NN cord-013590-pkm81fq1 248 11 - - JJ cord-013590-pkm81fq1 248 12 immunoprecipitation immunoprecipitation JJ cord-013590-pkm81fq1 248 13 104 104 CD cord-013590-pkm81fq1 248 14 and and CC cord-013590-pkm81fq1 248 15 FRET fret NN cord-013590-pkm81fq1 248 16 . . . cord-013590-pkm81fq1 249 1 103 103 CD cord-013590-pkm81fq1 250 1 Interestingly interestingly RB cord-013590-pkm81fq1 250 2 , , , cord-013590-pkm81fq1 250 3 not not RB cord-013590-pkm81fq1 250 4 only only RB cord-013590-pkm81fq1 250 5 the the DT cord-013590-pkm81fq1 250 6 extracellular extracellular JJ cord-013590-pkm81fq1 250 7 IgV igv NN cord-013590-pkm81fq1 250 8 domains domain NNS cord-013590-pkm81fq1 250 9 of of IN cord-013590-pkm81fq1 250 10 BTN2A1 BTN2A1 NNP cord-013590-pkm81fq1 250 11 and and CC cord-013590-pkm81fq1 250 12 BTN3A1 BTN3A1 NNP cord-013590-pkm81fq1 250 13 but but CC cord-013590-pkm81fq1 250 14 also also RB cord-013590-pkm81fq1 250 15 their -PRON- PRP$ cord-013590-pkm81fq1 250 16 intracellular intracellular JJ cord-013590-pkm81fq1 250 17 regions region NNS cord-013590-pkm81fq1 250 18 seem seem VBP cord-013590-pkm81fq1 250 19 to to TO cord-013590-pkm81fq1 250 20 be be VB cord-013590-pkm81fq1 250 21 at at IN cord-013590-pkm81fq1 250 22 least least JJS cord-013590-pkm81fq1 250 23 in in IN cord-013590-pkm81fq1 250 24 close close JJ cord-013590-pkm81fq1 250 25 proximity proximity NN cord-013590-pkm81fq1 250 26 although although IN cord-013590-pkm81fq1 250 27 only only RB cord-013590-pkm81fq1 250 28 the the DT cord-013590-pkm81fq1 250 29 B30.2 B30.2 NNP cord-013590-pkm81fq1 250 30 domain domain NN cord-013590-pkm81fq1 250 31 of of IN cord-013590-pkm81fq1 250 32 BTN3A1 BTN3A1 NNP cord-013590-pkm81fq1 250 33 is be VBZ cord-013590-pkm81fq1 250 34 able able JJ cord-013590-pkm81fq1 250 35 to to TO cord-013590-pkm81fq1 250 36 bind bind VB cord-013590-pkm81fq1 250 37 p p NNP cord-013590-pkm81fq1 250 38 - - : cord-013590-pkm81fq1 250 39 Ag Ag NNP cord-013590-pkm81fq1 250 40 as as IN cord-013590-pkm81fq1 250 41 shown show VBN cord-013590-pkm81fq1 250 42 by by IN cord-013590-pkm81fq1 250 43 isothermal isothermal JJ cord-013590-pkm81fq1 250 44 calorimetry calorimetry NN cord-013590-pkm81fq1 250 45 ( ( -LRB- cord-013590-pkm81fq1 250 46 ITC ITC NNP cord-013590-pkm81fq1 250 47 ) ) -RRB- cord-013590-pkm81fq1 250 48 . . . cord-013590-pkm81fq1 251 1 94 94 CD cord-013590-pkm81fq1 251 2 , , , cord-013590-pkm81fq1 251 3 103 103 CD cord-013590-pkm81fq1 252 1 The the DT cord-013590-pkm81fq1 252 2 domains domain NNS cord-013590-pkm81fq1 252 3 of of IN cord-013590-pkm81fq1 252 4 the the DT cord-013590-pkm81fq1 252 5 Vγ9-chain Vγ9-chain NNP cord-013590-pkm81fq1 252 6 involved involve VBN cord-013590-pkm81fq1 252 7 in in IN cord-013590-pkm81fq1 252 8 interaction interaction NN cord-013590-pkm81fq1 252 9 with with IN cord-013590-pkm81fq1 252 10 BTN2A1 BTN2A1 NNP cord-013590-pkm81fq1 252 11 were be VBD cord-013590-pkm81fq1 252 12 determined determine VBN cord-013590-pkm81fq1 252 13 by by IN cord-013590-pkm81fq1 252 14 mutagenesis mutagenesis NN cord-013590-pkm81fq1 252 15 of of IN cord-013590-pkm81fq1 252 16 the the DT cord-013590-pkm81fq1 252 17 γδ γδ NNP cord-013590-pkm81fq1 252 18 TCR TCR NNP cord-013590-pkm81fq1 252 19 and and CC cord-013590-pkm81fq1 252 20 BTN2A1 BTN2A1 NNP cord-013590-pkm81fq1 252 21 and and CC cord-013590-pkm81fq1 252 22 molecular molecular JJ cord-013590-pkm81fq1 252 23 modeling modeling NN cord-013590-pkm81fq1 252 24 in in IN cord-013590-pkm81fq1 252 25 silico silico NN cord-013590-pkm81fq1 252 26 . . . cord-013590-pkm81fq1 253 1 The the DT cord-013590-pkm81fq1 253 2 data datum NNS cord-013590-pkm81fq1 253 3 suggest suggest VBP cord-013590-pkm81fq1 253 4 that that IN cord-013590-pkm81fq1 253 5 interaction interaction NN cord-013590-pkm81fq1 253 6 occurs occur VBZ cord-013590-pkm81fq1 253 7 between between IN cord-013590-pkm81fq1 253 8 the the DT cord-013590-pkm81fq1 253 9 C C NNP cord-013590-pkm81fq1 253 10 , , , cord-013590-pkm81fq1 253 11 C C NNP cord-013590-pkm81fq1 253 12 ' ' '' cord-013590-pkm81fq1 253 13 , , , cord-013590-pkm81fq1 253 14 F F NNP cord-013590-pkm81fq1 253 15 , , , cord-013590-pkm81fq1 253 16 and and CC cord-013590-pkm81fq1 253 17 G G NNP cord-013590-pkm81fq1 253 18 β β NN cord-013590-pkm81fq1 253 19 strands strand NNS cord-013590-pkm81fq1 253 20 ( ( -LRB- cord-013590-pkm81fq1 253 21 CFG cfg NN cord-013590-pkm81fq1 253 22 interface interface NN cord-013590-pkm81fq1 253 23 ) ) -RRB- cord-013590-pkm81fq1 253 24 of of IN cord-013590-pkm81fq1 253 25 BTN2A1 BTN2A1 NNP cord-013590-pkm81fq1 253 26 and and CC cord-013590-pkm81fq1 253 27 residues residue NNS cord-013590-pkm81fq1 253 28 of of IN cord-013590-pkm81fq1 253 29 the the DT cord-013590-pkm81fq1 253 30 germline germline NN cord-013590-pkm81fq1 253 31 - - HYPH cord-013590-pkm81fq1 253 32 encoded encode VBN cord-013590-pkm81fq1 253 33 hypervariable hypervariable JJ cord-013590-pkm81fq1 253 34 region region NN cord-013590-pkm81fq1 253 35 4 4 CD cord-013590-pkm81fq1 253 36 ( ( -LRB- cord-013590-pkm81fq1 253 37 HV4 HV4 NNP cord-013590-pkm81fq1 253 38 ) ) -RRB- cord-013590-pkm81fq1 253 39 as as RB cord-013590-pkm81fq1 253 40 well well RB cord-013590-pkm81fq1 253 41 as as IN cord-013590-pkm81fq1 253 42 CDR2γ CDR2γ NNP cord-013590-pkm81fq1 253 43 . . . cord-013590-pkm81fq1 253 44 104 104 CD cord-013590-pkm81fq1 254 1 The the DT cord-013590-pkm81fq1 254 2 results result NNS cord-013590-pkm81fq1 254 3 from from IN cord-013590-pkm81fq1 254 4 the the DT cord-013590-pkm81fq1 254 5 mutagenesis mutagenesis NN cord-013590-pkm81fq1 254 6 study study NN cord-013590-pkm81fq1 254 7 conducted conduct VBN cord-013590-pkm81fq1 254 8 by by IN cord-013590-pkm81fq1 254 9 Rigau Rigau NNP cord-013590-pkm81fq1 254 10 et et NNP cord-013590-pkm81fq1 254 11 al al NNP cord-013590-pkm81fq1 254 12 . . . cord-013590-pkm81fq1 255 1 103 103 CD cord-013590-pkm81fq1 255 2 were be VBD cord-013590-pkm81fq1 255 3 not not RB cord-013590-pkm81fq1 255 4 entirely entirely RB cord-013590-pkm81fq1 255 5 consistent consistent JJ cord-013590-pkm81fq1 255 6 with with IN cord-013590-pkm81fq1 255 7 these these DT cord-013590-pkm81fq1 255 8 observations observation NNS cord-013590-pkm81fq1 255 9 . . . cord-013590-pkm81fq1 256 1 Based base VBN cord-013590-pkm81fq1 256 2 on on IN cord-013590-pkm81fq1 256 3 their -PRON- PRP$ cord-013590-pkm81fq1 256 4 mutagenesis mutagenesis NN cord-013590-pkm81fq1 256 5 experiments experiment NNS cord-013590-pkm81fq1 256 6 , , , cord-013590-pkm81fq1 256 7 they -PRON- PRP cord-013590-pkm81fq1 256 8 concluded conclude VBD cord-013590-pkm81fq1 256 9 that that IN cord-013590-pkm81fq1 256 10 the the DT cord-013590-pkm81fq1 256 11 outer outer JJ cord-013590-pkm81fq1 256 12 face face NN cord-013590-pkm81fq1 256 13 of of IN cord-013590-pkm81fq1 256 14 the the DT cord-013590-pkm81fq1 256 15 ABED ABED NNP cord-013590-pkm81fq1 256 16 βsheet βsheet NNP cord-013590-pkm81fq1 256 17 is be VBZ cord-013590-pkm81fq1 256 18 important important JJ cord-013590-pkm81fq1 256 19 for for IN cord-013590-pkm81fq1 256 20 the the DT cord-013590-pkm81fq1 256 21 interaction interaction NN cord-013590-pkm81fq1 256 22 with with IN cord-013590-pkm81fq1 256 23 BTN2A1 BTN2A1 NNP cord-013590-pkm81fq1 256 24 . . . cord-013590-pkm81fq1 257 1 However however RB cord-013590-pkm81fq1 257 2 , , , cord-013590-pkm81fq1 257 3 in in IN cord-013590-pkm81fq1 257 4 both both DT cord-013590-pkm81fq1 257 5 cases case NNS cord-013590-pkm81fq1 257 6 the the DT cord-013590-pkm81fq1 257 7 interaction interaction NN cord-013590-pkm81fq1 257 8 interface interface NN cord-013590-pkm81fq1 257 9 of of IN cord-013590-pkm81fq1 257 10 the the DT cord-013590-pkm81fq1 257 11 Vγ9-chain Vγ9-chain NNP cord-013590-pkm81fq1 257 12 with with IN cord-013590-pkm81fq1 257 13 BTN2A1 BTN2A1 NNP cord-013590-pkm81fq1 257 14 was be VBD cord-013590-pkm81fq1 257 15 germline germline NN cord-013590-pkm81fq1 257 16 - - HYPH cord-013590-pkm81fq1 257 17 encoded encode VBN cord-013590-pkm81fq1 257 18 and and CC cord-013590-pkm81fq1 257 19 a a DT cord-013590-pkm81fq1 257 20 central central JJ cord-013590-pkm81fq1 257 21 glutamic glutamic NN cord-013590-pkm81fq1 257 22 acid acid NN cord-013590-pkm81fq1 257 23 residue residue NN cord-013590-pkm81fq1 257 24 at at IN cord-013590-pkm81fq1 257 25 position position NN cord-013590-pkm81fq1 257 26 70 70 CD cord-013590-pkm81fq1 257 27 was be VBD cord-013590-pkm81fq1 257 28 considered consider VBN cord-013590-pkm81fq1 257 29 to to TO cord-013590-pkm81fq1 257 30 be be VB cord-013590-pkm81fq1 257 31 relevant relevant JJ cord-013590-pkm81fq1 257 32 by by IN cord-013590-pkm81fq1 257 33 both both DT cord-013590-pkm81fq1 257 34 groups group NNS cord-013590-pkm81fq1 257 35 . . . cord-013590-pkm81fq1 258 1 Further further JJ cord-013590-pkm81fq1 258 2 investigation investigation NN cord-013590-pkm81fq1 258 3 might may MD cord-013590-pkm81fq1 258 4 be be VB cord-013590-pkm81fq1 258 5 required require VBN cord-013590-pkm81fq1 258 6 to to TO cord-013590-pkm81fq1 258 7 completely completely RB cord-013590-pkm81fq1 258 8 solve solve VB cord-013590-pkm81fq1 258 9 this this DT cord-013590-pkm81fq1 258 10 discrepancy discrepancy NN cord-013590-pkm81fq1 258 11 . . . cord-013590-pkm81fq1 259 1 A a DT cord-013590-pkm81fq1 259 2 still still RB cord-013590-pkm81fq1 259 3 unsolved unsolved JJ cord-013590-pkm81fq1 259 4 question question NN cord-013590-pkm81fq1 259 5 concerning concern VBG cord-013590-pkm81fq1 259 6 BTN BTN NNP cord-013590-pkm81fq1 259 7 - - HYPH cord-013590-pkm81fq1 259 8 mediated mediate VBN cord-013590-pkm81fq1 259 9 p p NN cord-013590-pkm81fq1 259 10 - - : cord-013590-pkm81fq1 259 11 Agreactivity Agreactivity NNP cord-013590-pkm81fq1 259 12 is be VBZ cord-013590-pkm81fq1 259 13 how how WRB cord-013590-pkm81fq1 259 14 the the DT cord-013590-pkm81fq1 259 15 CDR3γ CDR3γ NNP cord-013590-pkm81fq1 259 16 and and CC cord-013590-pkm81fq1 259 17 CDR3δ CDR3δ NNP cord-013590-pkm81fq1 259 18 , , , cord-013590-pkm81fq1 259 19 which which WDT cord-013590-pkm81fq1 259 20 are be VBP cord-013590-pkm81fq1 259 21 both both DT cord-013590-pkm81fq1 259 22 reported report VBN cord-013590-pkm81fq1 259 23 to to TO cord-013590-pkm81fq1 259 24 be be VB cord-013590-pkm81fq1 259 25 required require VBN cord-013590-pkm81fq1 259 26 for for IN cord-013590-pkm81fq1 259 27 a a DT cord-013590-pkm81fq1 259 28 Vγ9Vδ2 vγ9vδ2 NN cord-013590-pkm81fq1 260 1 + + CC cord-013590-pkm81fq1 261 1 TCR TCR NNP cord-013590-pkm81fq1 261 2 response response NN cord-013590-pkm81fq1 261 3 to to IN cord-013590-pkm81fq1 261 4 p p NN cord-013590-pkm81fq1 261 5 - - : cord-013590-pkm81fq1 261 6 Ag Ag NNP cord-013590-pkm81fq1 261 7 , , , cord-013590-pkm81fq1 261 8 are be VBP cord-013590-pkm81fq1 261 9 involved involve VBN cord-013590-pkm81fq1 261 10 in in IN cord-013590-pkm81fq1 261 11 this this DT cord-013590-pkm81fq1 261 12 process process NN cord-013590-pkm81fq1 261 13 . . . cord-013590-pkm81fq1 262 1 105 105 CD cord-013590-pkm81fq1 262 2 Mutations mutation NNS cord-013590-pkm81fq1 262 3 in in IN cord-013590-pkm81fq1 262 4 the the DT cord-013590-pkm81fq1 262 5 CDR3γ CDR3γ NNP cord-013590-pkm81fq1 262 6 and and CC cord-013590-pkm81fq1 262 7 the the DT cord-013590-pkm81fq1 262 8 CDR2δ CDR2δ NNP cord-013590-pkm81fq1 262 9 led lead VBD cord-013590-pkm81fq1 262 10 furthermore furthermore RB cord-013590-pkm81fq1 262 11 to to IN cord-013590-pkm81fq1 262 12 the the DT cord-013590-pkm81fq1 262 13 abrogation abrogation NN cord-013590-pkm81fq1 262 14 of of IN cord-013590-pkm81fq1 262 15 p p NN cord-013590-pkm81fq1 262 16 - - : cord-013590-pkm81fq1 262 17 Ag Ag NNP cord-013590-pkm81fq1 262 18 reactivity reactivity NN cord-013590-pkm81fq1 262 19 but but CC cord-013590-pkm81fq1 262 20 not not RB cord-013590-pkm81fq1 262 21 the the DT cord-013590-pkm81fq1 262 22 binding binding NN cord-013590-pkm81fq1 262 23 of of IN cord-013590-pkm81fq1 262 24 the the DT cord-013590-pkm81fq1 262 25 Vγ9-chain vγ9-chain NN cord-013590-pkm81fq1 262 26 to to IN cord-013590-pkm81fq1 262 27 BTN2A1 BTN2A1 NNP cord-013590-pkm81fq1 262 28 . . . cord-013590-pkm81fq1 263 1 This this DT cord-013590-pkm81fq1 263 2 indicated indicate VBD cord-013590-pkm81fq1 263 3 that that IN cord-013590-pkm81fq1 263 4 binding bind VBG cord-013590-pkm81fq1 263 5 to to IN cord-013590-pkm81fq1 263 6 BTN2A1 BTN2A1 NNP cord-013590-pkm81fq1 263 7 is be VBZ cord-013590-pkm81fq1 263 8 required require VBN cord-013590-pkm81fq1 263 9 but but CC cord-013590-pkm81fq1 263 10 not not RB cord-013590-pkm81fq1 263 11 sufficient sufficient JJ cord-013590-pkm81fq1 263 12 for for IN cord-013590-pkm81fq1 263 13 a a DT cord-013590-pkm81fq1 263 14 Vγ9Vδ2 vγ9vδ2 NN cord-013590-pkm81fq1 264 1 + + CC cord-013590-pkm81fq1 264 2 TCR TCR NNP cord-013590-pkm81fq1 264 3 - - HYPH cord-013590-pkm81fq1 264 4 mediated mediate VBN cord-013590-pkm81fq1 264 5 response response NN cord-013590-pkm81fq1 264 6 . . . cord-013590-pkm81fq1 265 1 103 103 CD cord-013590-pkm81fq1 266 1 Thus thus RB cord-013590-pkm81fq1 266 2 , , , cord-013590-pkm81fq1 266 3 it -PRON- PRP cord-013590-pkm81fq1 266 4 has have VBZ cord-013590-pkm81fq1 266 5 been be VBN cord-013590-pkm81fq1 266 6 speculated speculate VBN cord-013590-pkm81fq1 266 7 that that IN cord-013590-pkm81fq1 266 8 at at RB cord-013590-pkm81fq1 266 9 least least JJS cord-013590-pkm81fq1 266 10 a a DT cord-013590-pkm81fq1 266 11 second second JJ cord-013590-pkm81fq1 266 12 interaction interaction NN cord-013590-pkm81fq1 266 13 is be VBZ cord-013590-pkm81fq1 266 14 necessary necessary JJ cord-013590-pkm81fq1 266 15 . . . cord-013590-pkm81fq1 267 1 Whether whether IN cord-013590-pkm81fq1 267 2 this this DT cord-013590-pkm81fq1 267 3 is be VBZ cord-013590-pkm81fq1 267 4 mediated mediate VBN cord-013590-pkm81fq1 267 5 by by IN cord-013590-pkm81fq1 267 6 BTN3A1 BTN3A1 NNP cord-013590-pkm81fq1 267 7 as as IN cord-013590-pkm81fq1 267 8 proposed propose VBN cord-013590-pkm81fq1 267 9 by by IN cord-013590-pkm81fq1 267 10 Rigau Rigau NNP cord-013590-pkm81fq1 267 11 et et NNP cord-013590-pkm81fq1 267 12 al al NNP cord-013590-pkm81fq1 267 13 . . . cord-013590-pkm81fq1 268 1 103 103 CD cord-013590-pkm81fq1 268 2 or or CC cord-013590-pkm81fq1 269 1 if if IN cord-013590-pkm81fq1 269 2 a a DT cord-013590-pkm81fq1 269 3 yet yet RB cord-013590-pkm81fq1 269 4 completely completely RB cord-013590-pkm81fq1 269 5 unknown unknown JJ cord-013590-pkm81fq1 269 6 ligand ligand NN cord-013590-pkm81fq1 269 7 is be VBZ cord-013590-pkm81fq1 269 8 involved involve VBN cord-013590-pkm81fq1 269 9 as as IN cord-013590-pkm81fq1 269 10 suggested suggest VBN cord-013590-pkm81fq1 269 11 by by IN cord-013590-pkm81fq1 269 12 Karunakaran Karunakaran NNP cord-013590-pkm81fq1 269 13 et et NNP cord-013590-pkm81fq1 269 14 al al NNP cord-013590-pkm81fq1 269 15 . . . cord-013590-pkm81fq1 270 1 , , , cord-013590-pkm81fq1 270 2 104 104 CD cord-013590-pkm81fq1 270 3 remains remain VBZ cord-013590-pkm81fq1 270 4 to to TO cord-013590-pkm81fq1 270 5 be be VB cord-013590-pkm81fq1 270 6 defined define VBN cord-013590-pkm81fq1 270 7 . . . cord-013590-pkm81fq1 271 1 The the DT cord-013590-pkm81fq1 271 2 role role NN cord-013590-pkm81fq1 271 3 of of IN cord-013590-pkm81fq1 271 4 butyrophilins butyrophilin NNS cord-013590-pkm81fq1 271 5 in in IN cord-013590-pkm81fq1 271 6 γδ γδ NNP cord-013590-pkm81fq1 271 7 T t NN cord-013590-pkm81fq1 271 8 - - HYPH cord-013590-pkm81fq1 271 9 cell cell NN cord-013590-pkm81fq1 271 10 biology biology NN cord-013590-pkm81fq1 271 11 exceeds exceed VBZ cord-013590-pkm81fq1 271 12 their -PRON- PRP$ cord-013590-pkm81fq1 271 13 implication implication NN cord-013590-pkm81fq1 271 14 in in IN cord-013590-pkm81fq1 271 15 p p NN cord-013590-pkm81fq1 271 16 - - : cord-013590-pkm81fq1 271 17 Ag Ag NNP cord-013590-pkm81fq1 271 18 sensing sensing NN cord-013590-pkm81fq1 271 19 and and CC cord-013590-pkm81fq1 271 20 the the DT cord-013590-pkm81fq1 271 21 activation activation NN cord-013590-pkm81fq1 271 22 of of IN cord-013590-pkm81fq1 271 23 Vγ9Vδ2 Vγ9Vδ2 NNS cord-013590-pkm81fq1 271 24 + + CC cord-013590-pkm81fq1 271 25 TCRs tcr NNS cord-013590-pkm81fq1 271 26 . . . cord-013590-pkm81fq1 272 1 Other other JJ cord-013590-pkm81fq1 272 2 proteins protein NNS cord-013590-pkm81fq1 272 3 with with IN cord-013590-pkm81fq1 272 4 structural structural JJ cord-013590-pkm81fq1 272 5 similarity similarity NN cord-013590-pkm81fq1 272 6 to to IN cord-013590-pkm81fq1 272 7 the the DT cord-013590-pkm81fq1 272 8 B7 B7 NNP cord-013590-pkm81fq1 272 9 receptor receptor NN cord-013590-pkm81fq1 272 10 superfamily superfamily NN cord-013590-pkm81fq1 272 11 such such JJ cord-013590-pkm81fq1 272 12 as as IN cord-013590-pkm81fq1 272 13 Skint-1 Skint-1 NNP cord-013590-pkm81fq1 272 14 and and CC cord-013590-pkm81fq1 272 15 Butyrophilin Butyrophilin NNP cord-013590-pkm81fq1 272 16 - - HYPH cord-013590-pkm81fq1 272 17 like like JJ cord-013590-pkm81fq1 272 18 ( ( -LRB- cord-013590-pkm81fq1 272 19 Btnl)1 Btnl)1 NNP cord-013590-pkm81fq1 272 20 and and CC cord-013590-pkm81fq1 272 21 6 6 CD cord-013590-pkm81fq1 272 22 in in IN cord-013590-pkm81fq1 272 23 mice mouse NNS cord-013590-pkm81fq1 272 24 as as RB cord-013590-pkm81fq1 272 25 well well RB cord-013590-pkm81fq1 272 26 as as IN cord-013590-pkm81fq1 272 27 BTNL3 BTNL3 NNS cord-013590-pkm81fq1 272 28 and and CC cord-013590-pkm81fq1 272 29 8 8 CD cord-013590-pkm81fq1 272 30 in in IN cord-013590-pkm81fq1 272 31 humans human NNS cord-013590-pkm81fq1 272 32 were be VBD cord-013590-pkm81fq1 272 33 shown show VBN cord-013590-pkm81fq1 272 34 to to TO cord-013590-pkm81fq1 272 35 be be VB cord-013590-pkm81fq1 272 36 relevant relevant JJ cord-013590-pkm81fq1 272 37 for for IN cord-013590-pkm81fq1 272 38 the the DT cord-013590-pkm81fq1 272 39 development development NN cord-013590-pkm81fq1 272 40 and and CC cord-013590-pkm81fq1 272 41 possibly possibly RB cord-013590-pkm81fq1 272 42 for for IN cord-013590-pkm81fq1 272 43 the the DT cord-013590-pkm81fq1 272 44 tissue tissue NN cord-013590-pkm81fq1 272 45 homing homing NN cord-013590-pkm81fq1 272 46 and and CC cord-013590-pkm81fq1 272 47 homeostasis homeostasis NN cord-013590-pkm81fq1 272 48 of of IN cord-013590-pkm81fq1 272 49 certain certain JJ cord-013590-pkm81fq1 272 50 γδ γδ NNP cord-013590-pkm81fq1 272 51 T t NN cord-013590-pkm81fq1 272 52 - - HYPH cord-013590-pkm81fq1 272 53 cell cell NN cord-013590-pkm81fq1 272 54 subsets subset NNS cord-013590-pkm81fq1 272 55 as as IN cord-013590-pkm81fq1 272 56 has have VBZ cord-013590-pkm81fq1 272 57 been be VBN cord-013590-pkm81fq1 272 58 reviewed review VBN cord-013590-pkm81fq1 272 59 recently recently RB cord-013590-pkm81fq1 272 60 by by IN cord-013590-pkm81fq1 272 61 Haday Haday NNP cord-013590-pkm81fq1 272 62 and and CC cord-013590-pkm81fq1 272 63 Vantourout Vantourout NNP cord-013590-pkm81fq1 272 64 . . . cord-013590-pkm81fq1 273 1 17 17 CD cord-013590-pkm81fq1 273 2 Murine Murine NNP cord-013590-pkm81fq1 273 3 DETCs DETCs NNPS cord-013590-pkm81fq1 273 4 bearing bear VBG cord-013590-pkm81fq1 273 5 a a DT cord-013590-pkm81fq1 273 6 canonical canonical JJ cord-013590-pkm81fq1 273 7 Vγ5Vδ1 vγ5vδ1 NN cord-013590-pkm81fq1 274 1 + + CC cord-013590-pkm81fq1 274 2 TCR TCR NNP cord-013590-pkm81fq1 274 3 require require VB cord-013590-pkm81fq1 274 4 Skint-1 Skint-1 NNP cord-013590-pkm81fq1 274 5 expression expression NN cord-013590-pkm81fq1 274 6 , , , cord-013590-pkm81fq1 274 7 since since IN cord-013590-pkm81fq1 274 8 mice mouse NNS cord-013590-pkm81fq1 274 9 with with IN cord-013590-pkm81fq1 274 10 a a DT cord-013590-pkm81fq1 274 11 mutation mutation NN cord-013590-pkm81fq1 274 12 in in IN cord-013590-pkm81fq1 274 13 the the DT cord-013590-pkm81fq1 274 14 Skint-1 Skint-1 NNP cord-013590-pkm81fq1 274 15 gene gene NN cord-013590-pkm81fq1 274 16 leading lead VBG cord-013590-pkm81fq1 274 17 to to IN cord-013590-pkm81fq1 274 18 a a DT cord-013590-pkm81fq1 274 19 premature premature JJ cord-013590-pkm81fq1 274 20 insertion insertion NN cord-013590-pkm81fq1 274 21 of of IN cord-013590-pkm81fq1 274 22 a a DT cord-013590-pkm81fq1 274 23 stop stop VB cord-013590-pkm81fq1 274 24 - - HYPH cord-013590-pkm81fq1 274 25 codon codon NN cord-013590-pkm81fq1 274 26 lack lack NN cord-013590-pkm81fq1 274 27 this this DT cord-013590-pkm81fq1 274 28 skin skin NN cord-013590-pkm81fq1 274 29 - - HYPH cord-013590-pkm81fq1 274 30 resident resident NN cord-013590-pkm81fq1 274 31 γδ γδ NNP cord-013590-pkm81fq1 274 32 T t NN cord-013590-pkm81fq1 274 33 - - HYPH cord-013590-pkm81fq1 274 34 cell cell NN cord-013590-pkm81fq1 274 35 subset subset NN cord-013590-pkm81fq1 274 36 . . . cord-013590-pkm81fq1 275 1 106 106 CD cord-013590-pkm81fq1 275 2 , , , cord-013590-pkm81fq1 275 3 107 107 CD cord-013590-pkm81fq1 276 1 It -PRON- PRP cord-013590-pkm81fq1 276 2 is be VBZ cord-013590-pkm81fq1 276 3 in in IN cord-013590-pkm81fq1 276 4 particular particular JJ cord-013590-pkm81fq1 276 5 the the DT cord-013590-pkm81fq1 276 6 homing homing NN cord-013590-pkm81fq1 276 7 to to IN cord-013590-pkm81fq1 276 8 the the DT cord-013590-pkm81fq1 276 9 skin skin NN cord-013590-pkm81fq1 276 10 as as RB cord-013590-pkm81fq1 276 11 well well RB cord-013590-pkm81fq1 276 12 as as IN cord-013590-pkm81fq1 276 13 the the DT cord-013590-pkm81fq1 276 14 phenotype phenotype NN cord-013590-pkm81fq1 276 15 of of IN cord-013590-pkm81fq1 276 16 these these DT cord-013590-pkm81fq1 276 17 Vγ5Vδ1 Vγ5Vδ1 NNS cord-013590-pkm81fq1 276 18 + + CC cord-013590-pkm81fq1 276 19 T t NN cord-013590-pkm81fq1 276 20 cells cell NNS cord-013590-pkm81fq1 276 21 that that WDT cord-013590-pkm81fq1 276 22 is be VBZ cord-013590-pkm81fq1 276 23 affected affect VBN cord-013590-pkm81fq1 276 24 rather rather RB cord-013590-pkm81fq1 276 25 than than IN cord-013590-pkm81fq1 276 26 their -PRON- PRP$ cord-013590-pkm81fq1 276 27 differentiation differentiation NN cord-013590-pkm81fq1 276 28 in in IN cord-013590-pkm81fq1 276 29 general general JJ cord-013590-pkm81fq1 276 30 . . . cord-013590-pkm81fq1 277 1 108 108 CD cord-013590-pkm81fq1 278 1 This this DT cord-013590-pkm81fq1 278 2 effect effect NN cord-013590-pkm81fq1 278 3 was be VBD cord-013590-pkm81fq1 278 4 additionally additionally RB cord-013590-pkm81fq1 278 5 shown show VBN cord-013590-pkm81fq1 278 6 to to TO cord-013590-pkm81fq1 278 7 be be VB cord-013590-pkm81fq1 278 8 γδ γδ IN cord-013590-pkm81fq1 278 9 TCR TCR NNP cord-013590-pkm81fq1 278 10 - - HYPH cord-013590-pkm81fq1 278 11 dependent dependent JJ cord-013590-pkm81fq1 278 12 , , , cord-013590-pkm81fq1 278 13 which which WDT cord-013590-pkm81fq1 278 14 makes make VBZ cord-013590-pkm81fq1 278 15 Skint-1 Skint-1 NNP cord-013590-pkm81fq1 278 16 a a DT cord-013590-pkm81fq1 278 17 putative putative JJ cord-013590-pkm81fq1 278 18 ligand ligand NN cord-013590-pkm81fq1 278 19 . . . cord-013590-pkm81fq1 279 1 109 109 CD cord-013590-pkm81fq1 279 2 , , , cord-013590-pkm81fq1 279 3 110 110 CD cord-013590-pkm81fq1 279 4 Mutagenesis Mutagenesis NNP cord-013590-pkm81fq1 279 5 of of IN cord-013590-pkm81fq1 279 6 the the DT cord-013590-pkm81fq1 279 7 membrane membrane NN cord-013590-pkm81fq1 279 8 distal distal JJ cord-013590-pkm81fq1 279 9 domain domain NN cord-013590-pkm81fq1 279 10 of of IN cord-013590-pkm81fq1 279 11 Skint-1 Skint-1 NNP cord-013590-pkm81fq1 279 12 and and CC cord-013590-pkm81fq1 279 13 NMR NMR NNP cord-013590-pkm81fq1 279 14 - - HYPH cord-013590-pkm81fq1 279 15 studies study NNS cord-013590-pkm81fq1 279 16 suggest suggest VBP cord-013590-pkm81fq1 279 17 a a DT cord-013590-pkm81fq1 279 18 putative putative JJ cord-013590-pkm81fq1 279 19 receptor receptor NN cord-013590-pkm81fq1 279 20 - - HYPH cord-013590-pkm81fq1 279 21 interaction interaction NN cord-013590-pkm81fq1 279 22 surface surface NN cord-013590-pkm81fq1 279 23 but but CC cord-013590-pkm81fq1 279 24 a a DT cord-013590-pkm81fq1 279 25 direct direct JJ cord-013590-pkm81fq1 279 26 interaction interaction NN cord-013590-pkm81fq1 279 27 with with IN cord-013590-pkm81fq1 279 28 the the DT cord-013590-pkm81fq1 279 29 γδ γδ NN cord-013590-pkm81fq1 280 1 TCR TCR NNP cord-013590-pkm81fq1 280 2 has have VBZ cord-013590-pkm81fq1 280 3 not not RB cord-013590-pkm81fq1 280 4 been be VBN cord-013590-pkm81fq1 280 5 shown show VBN cord-013590-pkm81fq1 280 6 so so RB cord-013590-pkm81fq1 280 7 far far RB cord-013590-pkm81fq1 280 8 . . . cord-013590-pkm81fq1 281 1 111 111 CD cord-013590-pkm81fq1 282 1 The the DT cord-013590-pkm81fq1 282 2 case case NN cord-013590-pkm81fq1 282 3 of of IN cord-013590-pkm81fq1 282 4 Btnl Btnl NNP cord-013590-pkm81fq1 282 5 / / SYM cord-013590-pkm81fq1 282 6 BTNL BTNL NNP cord-013590-pkm81fq1 282 7 proteins protein NNS cord-013590-pkm81fq1 282 8 in in IN cord-013590-pkm81fq1 282 9 mice mouse NNS cord-013590-pkm81fq1 282 10 and and CC cord-013590-pkm81fq1 282 11 humans human NNS cord-013590-pkm81fq1 282 12 seems seem VBZ cord-013590-pkm81fq1 282 13 to to TO cord-013590-pkm81fq1 282 14 be be VB cord-013590-pkm81fq1 282 15 , , , cord-013590-pkm81fq1 282 16 however however RB cord-013590-pkm81fq1 282 17 , , , cord-013590-pkm81fq1 282 18 much much RB cord-013590-pkm81fq1 282 19 clearer clear JJR cord-013590-pkm81fq1 282 20 . . . cord-013590-pkm81fq1 283 1 Btnl1 Btnl1 NNP cord-013590-pkm81fq1 283 2 and and CC cord-013590-pkm81fq1 283 3 6 6 CD cord-013590-pkm81fq1 283 4 form form NN cord-013590-pkm81fq1 283 5 heterodimers heterodimer NNS cord-013590-pkm81fq1 283 6 and and CC cord-013590-pkm81fq1 283 7 are be VBP cord-013590-pkm81fq1 283 8 required require VBN cord-013590-pkm81fq1 283 9 for for IN cord-013590-pkm81fq1 283 10 the the DT cord-013590-pkm81fq1 283 11 development development NN cord-013590-pkm81fq1 283 12 of of IN cord-013590-pkm81fq1 283 13 Vγ7 Vγ7 NNP cord-013590-pkm81fq1 283 14 + + CC cord-013590-pkm81fq1 283 15 IELs iel NNS cord-013590-pkm81fq1 283 16 in in IN cord-013590-pkm81fq1 283 17 the the DT cord-013590-pkm81fq1 283 18 gut gut NN cord-013590-pkm81fq1 283 19 in in IN cord-013590-pkm81fq1 283 20 a a DT cord-013590-pkm81fq1 283 21 γδ γδ NN cord-013590-pkm81fq1 283 22 TCRdependent tcrdependent NN cord-013590-pkm81fq1 283 23 manner manner NN cord-013590-pkm81fq1 283 24 . . . cord-013590-pkm81fq1 284 1 Likewise likewise RB cord-013590-pkm81fq1 284 2 , , , cord-013590-pkm81fq1 284 3 human human JJ cord-013590-pkm81fq1 284 4 intestinal intestinal JJ cord-013590-pkm81fq1 284 5 Vγ4 vγ4 NN cord-013590-pkm81fq1 284 6 + + CC cord-013590-pkm81fq1 284 7 TCRs tcr NNS cord-013590-pkm81fq1 284 8 can can MD cord-013590-pkm81fq1 284 9 be be VB cord-013590-pkm81fq1 284 10 activated activate VBN cord-013590-pkm81fq1 284 11 by by IN cord-013590-pkm81fq1 284 12 the the DT cord-013590-pkm81fq1 284 13 co co NN cord-013590-pkm81fq1 284 14 - - VBD cord-013590-pkm81fq1 284 15 expressed express VBN cord-013590-pkm81fq1 284 16 Btnl Btnl NNP cord-013590-pkm81fq1 284 17 - - HYPH cord-013590-pkm81fq1 284 18 homologues homologue NNS cord-013590-pkm81fq1 284 19 BTNL3 BTNL3 NNS cord-013590-pkm81fq1 284 20 and and CC cord-013590-pkm81fq1 284 21 BTNL8 BTNL8 NNS cord-013590-pkm81fq1 284 22 . . . cord-013590-pkm81fq1 285 1 101 101 CD cord-013590-pkm81fq1 285 2 , , , cord-013590-pkm81fq1 285 3 112 112 CD cord-013590-pkm81fq1 285 4 TCR TCR NNP cord-013590-pkm81fq1 285 5 - - HYPH cord-013590-pkm81fq1 285 6 dependent dependent JJ cord-013590-pkm81fq1 285 7 responsiveness responsiveness NN cord-013590-pkm81fq1 285 8 to to IN cord-013590-pkm81fq1 285 9 BTNLs BTNLs NNP cord-013590-pkm81fq1 285 10 seems seem VBZ cord-013590-pkm81fq1 285 11 thus thus RB cord-013590-pkm81fq1 285 12 to to TO cord-013590-pkm81fq1 285 13 be be VB cord-013590-pkm81fq1 285 14 evolutionarily evolutionarily RB cord-013590-pkm81fq1 285 15 conserved conserve VBN cord-013590-pkm81fq1 285 16 . . . cord-013590-pkm81fq1 286 1 Recently recently RB cord-013590-pkm81fq1 286 2 , , , cord-013590-pkm81fq1 286 3 direct direct JJ cord-013590-pkm81fq1 286 4 binding binding NN cord-013590-pkm81fq1 286 5 as as RB cord-013590-pkm81fq1 286 6 well well RB cord-013590-pkm81fq1 286 7 as as IN cord-013590-pkm81fq1 286 8 the the DT cord-013590-pkm81fq1 286 9 mode mode NN cord-013590-pkm81fq1 286 10 of of IN cord-013590-pkm81fq1 286 11 interaction interaction NN cord-013590-pkm81fq1 286 12 of of IN cord-013590-pkm81fq1 286 13 Btnl Btnl NNP cord-013590-pkm81fq1 286 14 / / SYM cord-013590-pkm81fq1 286 15 BTNL BTNL NNP cord-013590-pkm81fq1 286 16 proteins protein NNS cord-013590-pkm81fq1 286 17 and and CC cord-013590-pkm81fq1 286 18 the the DT cord-013590-pkm81fq1 286 19 respective respective NNS cord-013590-pkm81fq1 286 20 γδ γδ IN cord-013590-pkm81fq1 286 21 TCRs tcr NNS cord-013590-pkm81fq1 286 22 were be VBD cord-013590-pkm81fq1 286 23 revealed reveal VBN cord-013590-pkm81fq1 286 24 . . . cord-013590-pkm81fq1 287 1 113 113 CD cord-013590-pkm81fq1 287 2 , , , cord-013590-pkm81fq1 287 3 114 114 CD cord-013590-pkm81fq1 288 1 The the DT cord-013590-pkm81fq1 288 2 interaction interaction NN cord-013590-pkm81fq1 288 3 was be VBD cord-013590-pkm81fq1 288 4 mediated mediate VBN cord-013590-pkm81fq1 288 5 via via IN cord-013590-pkm81fq1 288 6 the the DT cord-013590-pkm81fq1 288 7 germline germline NN cord-013590-pkm81fq1 288 8 - - HYPH cord-013590-pkm81fq1 288 9 encoded encode VBN cord-013590-pkm81fq1 288 10 γ γ NN cord-013590-pkm81fq1 288 11 - - HYPH cord-013590-pkm81fq1 288 12 chain chain NN cord-013590-pkm81fq1 288 13 HV4 hv4 NN cord-013590-pkm81fq1 288 14 with with IN cord-013590-pkm81fq1 288 15 the the DT cord-013590-pkm81fq1 288 16 involvement involvement NN cord-013590-pkm81fq1 288 17 of of IN cord-013590-pkm81fq1 288 18 some some DT cord-013590-pkm81fq1 288 19 CDR2 CDR2 NNP cord-013590-pkm81fq1 288 20 residues residue NNS cord-013590-pkm81fq1 288 21 and and CC cord-013590-pkm81fq1 288 22 the the DT cord-013590-pkm81fq1 288 23 CFG cfg NN cord-013590-pkm81fq1 288 24 - - HYPH cord-013590-pkm81fq1 288 25 domain domain NN cord-013590-pkm81fq1 288 26 of of IN cord-013590-pkm81fq1 288 27 Btnl6 Btnl6 NNS cord-013590-pkm81fq1 288 28 and and CC cord-013590-pkm81fq1 288 29 BTNL3 BTNL3 NNS cord-013590-pkm81fq1 288 30 , , , cord-013590-pkm81fq1 288 31 reminiscent reminiscent JJ cord-013590-pkm81fq1 288 32 of of IN cord-013590-pkm81fq1 288 33 superantigen superantigen NN cord-013590-pkm81fq1 288 34 binding bind VBG cord-013590-pkm81fq1 288 35 to to IN cord-013590-pkm81fq1 288 36 αβ αβ NNP cord-013590-pkm81fq1 288 37 TCRs TCRs NNPS cord-013590-pkm81fq1 288 38 . . . cord-013590-pkm81fq1 289 1 115 115 CD cord-013590-pkm81fq1 289 2 Other other JJ cord-013590-pkm81fq1 289 3 CDRs cdr NNS cord-013590-pkm81fq1 289 4 and and CC cord-013590-pkm81fq1 289 5 the the DT cord-013590-pkm81fq1 289 6 entire entire JJ cord-013590-pkm81fq1 289 7 δ δ NN cord-013590-pkm81fq1 289 8 - - HYPH cord-013590-pkm81fq1 289 9 chain chain NN cord-013590-pkm81fq1 289 10 were be VBD cord-013590-pkm81fq1 289 11 not not RB cord-013590-pkm81fq1 289 12 involved involved JJ cord-013590-pkm81fq1 289 13 but but CC cord-013590-pkm81fq1 289 14 are be VBP cord-013590-pkm81fq1 289 15 available available JJ cord-013590-pkm81fq1 289 16 for for IN cord-013590-pkm81fq1 289 17 clonally clonally RB cord-013590-pkm81fq1 289 18 specific specific JJ cord-013590-pkm81fq1 289 19 ligand ligand NN cord-013590-pkm81fq1 289 20 binding binding NN cord-013590-pkm81fq1 289 21 of of IN cord-013590-pkm81fq1 289 22 e.g. e.g. RB cord-013590-pkm81fq1 289 23 CD1-d CD1-d NNP cord-013590-pkm81fq1 289 24 or or CC cord-013590-pkm81fq1 289 25 EPCR EPCR NNP cord-013590-pkm81fq1 289 26 . . . cord-013590-pkm81fq1 290 1 This this DT cord-013590-pkm81fq1 290 2 indicates indicate VBZ cord-013590-pkm81fq1 290 3 that that DT cord-013590-pkm81fq1 290 4 γδ γδ IN cord-013590-pkm81fq1 290 5 TCRs tcr NNS cord-013590-pkm81fq1 290 6 are be VBP cord-013590-pkm81fq1 290 7 intrinsically intrinsically RB cord-013590-pkm81fq1 290 8 able able JJ cord-013590-pkm81fq1 290 9 to to TO cord-013590-pkm81fq1 290 10 combine combine VB cord-013590-pkm81fq1 290 11 clonal clonal JJ cord-013590-pkm81fq1 290 12 adaptive adaptive JJ cord-013590-pkm81fq1 290 13 reactivity reactivity NN cord-013590-pkm81fq1 290 14 and and CC cord-013590-pkm81fq1 290 15 nonclonal nonclonal NNP cord-013590-pkm81fq1 290 16 innate innate JJ cord-013590-pkm81fq1 290 17 responsiveness responsiveness NN cord-013590-pkm81fq1 290 18 to to IN cord-013590-pkm81fq1 290 19 common common JJ cord-013590-pkm81fq1 290 20 ligands ligand NNS cord-013590-pkm81fq1 290 21 . . . cord-013590-pkm81fq1 291 1 The the DT cord-013590-pkm81fq1 291 2 physiological physiological JJ cord-013590-pkm81fq1 291 3 role role NN cord-013590-pkm81fq1 291 4 of of IN cord-013590-pkm81fq1 291 5 BTNLresponsiveness btnlresponsiveness NN cord-013590-pkm81fq1 291 6 by by IN cord-013590-pkm81fq1 291 7 γδ γδ XX cord-013590-pkm81fq1 291 8 TCRs tcr NNS cord-013590-pkm81fq1 291 9 beyond beyond IN cord-013590-pkm81fq1 291 10 its -PRON- PRP$ cord-013590-pkm81fq1 291 11 implication implication NN cord-013590-pkm81fq1 291 12 in in IN cord-013590-pkm81fq1 291 13 γδ γδ NNP cord-013590-pkm81fq1 291 14 T t NN cord-013590-pkm81fq1 291 15 - - HYPH cord-013590-pkm81fq1 291 16 cell cell NN cord-013590-pkm81fq1 291 17 development development NN cord-013590-pkm81fq1 291 18 remains remain VBZ cord-013590-pkm81fq1 291 19 to to TO cord-013590-pkm81fq1 291 20 be be VB cord-013590-pkm81fq1 291 21 elucidated elucidate VBN cord-013590-pkm81fq1 291 22 . . . cord-013590-pkm81fq1 292 1 It -PRON- PRP cord-013590-pkm81fq1 292 2 has have VBZ cord-013590-pkm81fq1 292 3 , , , cord-013590-pkm81fq1 292 4 however however RB cord-013590-pkm81fq1 292 5 , , , cord-013590-pkm81fq1 292 6 been be VBN cord-013590-pkm81fq1 292 7 discussed discuss VBN cord-013590-pkm81fq1 292 8 , , , cord-013590-pkm81fq1 292 9 that that IN cord-013590-pkm81fq1 292 10 it -PRON- PRP cord-013590-pkm81fq1 292 11 may may MD cord-013590-pkm81fq1 292 12 serve serve VB cord-013590-pkm81fq1 292 13 as as IN cord-013590-pkm81fq1 292 14 a a DT cord-013590-pkm81fq1 292 15 signal signal NN cord-013590-pkm81fq1 292 16 of of IN cord-013590-pkm81fq1 292 17 normality normality NN cord-013590-pkm81fq1 292 18 , , , cord-013590-pkm81fq1 292 19 keeping keep VBG cord-013590-pkm81fq1 292 20 the the DT cord-013590-pkm81fq1 292 21 cells cell NNS cord-013590-pkm81fq1 292 22 ready ready JJ cord-013590-pkm81fq1 292 23 to to TO cord-013590-pkm81fq1 292 24 respond respond VB cord-013590-pkm81fq1 292 25 to to IN cord-013590-pkm81fq1 292 26 cognate cognate JJ cord-013590-pkm81fq1 292 27 antigens antigen NNS cord-013590-pkm81fq1 292 28 under under IN cord-013590-pkm81fq1 292 29 stress stress NN cord-013590-pkm81fq1 292 30 conditions condition NNS cord-013590-pkm81fq1 292 31 . . . cord-013590-pkm81fq1 293 1 17 17 CD cord-013590-pkm81fq1 293 2 , , , cord-013590-pkm81fq1 293 3 113 113 CD cord-013590-pkm81fq1 293 4 Whether whether IN cord-013590-pkm81fq1 293 5 germline germline RB cord-013590-pkm81fq1 293 6 - - HYPH cord-013590-pkm81fq1 293 7 encoded encode VBN cord-013590-pkm81fq1 293 8 recognition recognition NN cord-013590-pkm81fq1 293 9 of of IN cord-013590-pkm81fq1 293 10 B7 B7 NNP cord-013590-pkm81fq1 293 11 family family NN cord-013590-pkm81fq1 293 12 - - HYPH cord-013590-pkm81fq1 293 13 like like JJ cord-013590-pkm81fq1 293 14 proteins protein NNS cord-013590-pkm81fq1 293 15 via via IN cord-013590-pkm81fq1 293 16 the the DT cord-013590-pkm81fq1 293 17 γ γ NN cord-013590-pkm81fq1 293 18 - - HYPH cord-013590-pkm81fq1 293 19 chain chain NN cord-013590-pkm81fq1 293 20 HV4 hv4 NN cord-013590-pkm81fq1 293 21 extends extend VBZ cord-013590-pkm81fq1 293 22 also also RB cord-013590-pkm81fq1 293 23 to to IN cord-013590-pkm81fq1 293 24 other other JJ cord-013590-pkm81fq1 293 25 γδ γδ IN cord-013590-pkm81fq1 293 26 TCRs tcr NNS cord-013590-pkm81fq1 293 27 and and CC cord-013590-pkm81fq1 293 28 represents represent VBZ cord-013590-pkm81fq1 293 29 a a DT cord-013590-pkm81fq1 293 30 general general JJ cord-013590-pkm81fq1 293 31 principle principle NN cord-013590-pkm81fq1 293 32 is be VBZ cord-013590-pkm81fq1 293 33 unclear unclear JJ cord-013590-pkm81fq1 293 34 . . . cord-013590-pkm81fq1 294 1 The the DT cord-013590-pkm81fq1 294 2 tissue tissue NN cord-013590-pkm81fq1 294 3 - - HYPH cord-013590-pkm81fq1 294 4 specific specific JJ cord-013590-pkm81fq1 294 5 expression expression NN cord-013590-pkm81fq1 294 6 of of IN cord-013590-pkm81fq1 294 7 certain certain JJ cord-013590-pkm81fq1 294 8 γ γ NN cord-013590-pkm81fq1 294 9 - - HYPH cord-013590-pkm81fq1 294 10 chains chain NNS cord-013590-pkm81fq1 294 11 would would MD cord-013590-pkm81fq1 294 12 reflect reflect VB cord-013590-pkm81fq1 294 13 such such PDT cord-013590-pkm81fq1 294 14 a a DT cord-013590-pkm81fq1 294 15 broadly broadly RB cord-013590-pkm81fq1 294 16 applicable applicable JJ cord-013590-pkm81fq1 294 17 mechanism mechanism NN cord-013590-pkm81fq1 294 18 . . . cord-013590-pkm81fq1 295 1 116 116 CD cord-013590-pkm81fq1 296 1 Moreover moreover RB cord-013590-pkm81fq1 296 2 , , , cord-013590-pkm81fq1 296 3 the the DT cord-013590-pkm81fq1 296 4 recently recently RB cord-013590-pkm81fq1 296 5 investigated investigate VBN cord-013590-pkm81fq1 296 6 interaction interaction NN cord-013590-pkm81fq1 296 7 mode mode NN cord-013590-pkm81fq1 296 8 between between IN cord-013590-pkm81fq1 296 9 BTN2A1 BTN2A1 NNP cord-013590-pkm81fq1 296 10 and and CC cord-013590-pkm81fq1 296 11 the the DT cord-013590-pkm81fq1 296 12 public public JJ cord-013590-pkm81fq1 296 13 Vγ9JP vγ9jp NN cord-013590-pkm81fq1 296 14 - - HYPH cord-013590-pkm81fq1 296 15 chain chain NN cord-013590-pkm81fq1 296 16 follows follow VBZ cord-013590-pkm81fq1 296 17 the the DT cord-013590-pkm81fq1 296 18 same same JJ cord-013590-pkm81fq1 296 19 principle principle NN cord-013590-pkm81fq1 296 20 as as IN cord-013590-pkm81fq1 296 21 between between IN cord-013590-pkm81fq1 296 22 BTNL BTNL NNP cord-013590-pkm81fq1 296 23 / / SYM cord-013590-pkm81fq1 296 24 Btnl Btnl NNP cord-013590-pkm81fq1 296 25 proteins protein NNS cord-013590-pkm81fq1 296 26 and and CC cord-013590-pkm81fq1 296 27 γδ γδ IN cord-013590-pkm81fq1 296 28 TCRs tcr NNS cord-013590-pkm81fq1 296 29 . . . cord-013590-pkm81fq1 297 1 In in IN cord-013590-pkm81fq1 297 2 both both DT cord-013590-pkm81fq1 297 3 cases case NNS cord-013590-pkm81fq1 297 4 , , , cord-013590-pkm81fq1 297 5 the the DT cord-013590-pkm81fq1 297 6 HV4 HV4 NNP cord-013590-pkm81fq1 297 7 was be VBD cord-013590-pkm81fq1 297 8 described describe VBN cord-013590-pkm81fq1 297 9 as as IN cord-013590-pkm81fq1 297 10 the the DT cord-013590-pkm81fq1 297 11 major major JJ cord-013590-pkm81fq1 297 12 mediator mediator NN cord-013590-pkm81fq1 297 13 of of IN cord-013590-pkm81fq1 297 14 the the DT cord-013590-pkm81fq1 297 15 interaction interaction NN cord-013590-pkm81fq1 297 16 , , , cord-013590-pkm81fq1 297 17 suggesting suggest VBG cord-013590-pkm81fq1 297 18 that that IN cord-013590-pkm81fq1 297 19 a a DT cord-013590-pkm81fq1 297 20 binding binding NN cord-013590-pkm81fq1 297 21 mode mode NN cord-013590-pkm81fq1 297 22 via via IN cord-013590-pkm81fq1 297 23 germlineencoded germlineencoded JJ cord-013590-pkm81fq1 297 24 domains domain NNS cord-013590-pkm81fq1 297 25 might may MD cord-013590-pkm81fq1 297 26 describe describe VB cord-013590-pkm81fq1 297 27 a a DT cord-013590-pkm81fq1 297 28 more more RBR cord-013590-pkm81fq1 297 29 general general JJ cord-013590-pkm81fq1 297 30 feature feature NN cord-013590-pkm81fq1 297 31 of of IN cord-013590-pkm81fq1 297 32 butyrophilin butyrophilin NN cord-013590-pkm81fq1 297 33 binding bind VBG cord-013590-pkm81fq1 297 34 by by IN cord-013590-pkm81fq1 297 35 γδ γδ IN cord-013590-pkm81fq1 297 36 TCRs tcr NNS cord-013590-pkm81fq1 297 37 . . . cord-013590-pkm81fq1 298 1 Hallmarks Hallmarks NNP cord-013590-pkm81fq1 298 2 of of IN cord-013590-pkm81fq1 298 3 antigen antigen NN cord-013590-pkm81fq1 298 4 recognition recognition NN cord-013590-pkm81fq1 298 5 by by IN cord-013590-pkm81fq1 298 6 αβ αβ NNP cord-013590-pkm81fq1 298 7 TCRs TCRs NNP cord-013590-pkm81fq1 298 8 are be VBP cord-013590-pkm81fq1 298 9 the the DT cord-013590-pkm81fq1 298 10 recognition recognition NN cord-013590-pkm81fq1 298 11 of of IN cord-013590-pkm81fq1 298 12 pathogen pathogen NN cord-013590-pkm81fq1 298 13 - - HYPH cord-013590-pkm81fq1 298 14 derived derive VBN cord-013590-pkm81fq1 298 15 peptides peptide NNS cord-013590-pkm81fq1 298 16 presented present VBN cord-013590-pkm81fq1 298 17 by by IN cord-013590-pkm81fq1 298 18 MHC MHC NNP cord-013590-pkm81fq1 298 19 molecules molecule NNS cord-013590-pkm81fq1 298 20 and and CC cord-013590-pkm81fq1 298 21 additional additional JJ cord-013590-pkm81fq1 298 22 regulation regulation NN cord-013590-pkm81fq1 298 23 via via IN cord-013590-pkm81fq1 298 24 co co NNS cord-013590-pkm81fq1 298 25 - - NNS cord-013590-pkm81fq1 298 26 receptors receptor NNS cord-013590-pkm81fq1 298 27 , , , cord-013590-pkm81fq1 298 28 which which WDT cord-013590-pkm81fq1 298 29 allow allow VBP cord-013590-pkm81fq1 298 30 all all DT cord-013590-pkm81fq1 298 31 together together RB cord-013590-pkm81fq1 298 32 the the DT cord-013590-pkm81fq1 298 33 fine fine RB cord-013590-pkm81fq1 298 34 - - HYPH cord-013590-pkm81fq1 298 35 tuned tune VBN cord-013590-pkm81fq1 298 36 discrimination discrimination NN cord-013590-pkm81fq1 298 37 of of IN cord-013590-pkm81fq1 298 38 foreign foreign NN cord-013590-pkm81fq1 298 39 from from IN cord-013590-pkm81fq1 298 40 self self NN cord-013590-pkm81fq1 298 41 . . . cord-013590-pkm81fq1 299 1 Ligands Ligands NNP cord-013590-pkm81fq1 299 2 of of IN cord-013590-pkm81fq1 299 3 γδ γδ NNP cord-013590-pkm81fq1 299 4 TCRs TCRs NNP cord-013590-pkm81fq1 299 5 , , , cord-013590-pkm81fq1 299 6 however however RB cord-013590-pkm81fq1 299 7 , , , cord-013590-pkm81fq1 299 8 are be VBP cord-013590-pkm81fq1 299 9 representing represent VBG cord-013590-pkm81fq1 299 10 a a DT cord-013590-pkm81fq1 299 11 wide wide JJ cord-013590-pkm81fq1 299 12 range range NN cord-013590-pkm81fq1 299 13 of of IN cord-013590-pkm81fq1 299 14 largely largely RB cord-013590-pkm81fq1 299 15 host host NN cord-013590-pkm81fq1 299 16 - - HYPH cord-013590-pkm81fq1 299 17 cellderived cellderived JJ cord-013590-pkm81fq1 299 18 molecules molecule NNS cord-013590-pkm81fq1 299 19 , , , cord-013590-pkm81fq1 299 20 which which WDT cord-013590-pkm81fq1 299 21 are be VBP cord-013590-pkm81fq1 299 22 believed believe VBN cord-013590-pkm81fq1 299 23 to to TO cord-013590-pkm81fq1 299 24 be be VB cord-013590-pkm81fq1 299 25 signals signal NNS cord-013590-pkm81fq1 299 26 of of IN cord-013590-pkm81fq1 299 27 cellular cellular JJ cord-013590-pkm81fq1 299 28 stress stress NN cord-013590-pkm81fq1 299 29 ( ( -LRB- cord-013590-pkm81fq1 299 30 see see VB cord-013590-pkm81fq1 299 31 Table table NN cord-013590-pkm81fq1 299 32 1 1 CD cord-013590-pkm81fq1 299 33 ) ) -RRB- cord-013590-pkm81fq1 299 34 . . . cord-013590-pkm81fq1 300 1 Hence hence RB cord-013590-pkm81fq1 300 2 , , , cord-013590-pkm81fq1 300 3 the the DT cord-013590-pkm81fq1 300 4 question question NN cord-013590-pkm81fq1 300 5 arises arise VBZ cord-013590-pkm81fq1 300 6 of of IN cord-013590-pkm81fq1 300 7 how how WRB cord-013590-pkm81fq1 300 8 γδ γδ NNP cord-013590-pkm81fq1 300 9 T t NN cord-013590-pkm81fq1 300 10 cells cell NNS cord-013590-pkm81fq1 300 11 are be VBP cord-013590-pkm81fq1 300 12 able able JJ cord-013590-pkm81fq1 300 13 to to TO cord-013590-pkm81fq1 300 14 discriminate discriminate VB cord-013590-pkm81fq1 300 15 normal normal JJ cord-013590-pkm81fq1 300 16 homeostatic homeostatic JJ cord-013590-pkm81fq1 300 17 conditions condition NNS cord-013590-pkm81fq1 300 18 from from IN cord-013590-pkm81fq1 300 19 pathological pathological JJ cord-013590-pkm81fq1 300 20 ones one NNS cord-013590-pkm81fq1 300 21 . . . cord-013590-pkm81fq1 301 1 Especially especially RB cord-013590-pkm81fq1 301 2 the the DT cord-013590-pkm81fq1 301 3 direct direct JJ cord-013590-pkm81fq1 301 4 Ig Ig NNP cord-013590-pkm81fq1 301 5 - - HYPH cord-013590-pkm81fq1 301 6 like like JJ cord-013590-pkm81fq1 301 7 binding binding NN cord-013590-pkm81fq1 301 8 of of IN cord-013590-pkm81fq1 301 9 the the DT cord-013590-pkm81fq1 301 10 antigen antigen NN cord-013590-pkm81fq1 301 11 harbors harbor VBZ cord-013590-pkm81fq1 301 12 the the DT cord-013590-pkm81fq1 301 13 potential potential NN cord-013590-pkm81fq1 301 14 for for IN cord-013590-pkm81fq1 301 15 autoimmune autoimmune JJ cord-013590-pkm81fq1 301 16 reactions reaction NNS cord-013590-pkm81fq1 301 17 and and CC cord-013590-pkm81fq1 301 18 thus thus RB cord-013590-pkm81fq1 301 19 molecular molecular JJ cord-013590-pkm81fq1 301 20 mechanisms mechanism NNS cord-013590-pkm81fq1 301 21 to to TO cord-013590-pkm81fq1 301 22 circumvent circumvent VB cord-013590-pkm81fq1 301 23 this this DT cord-013590-pkm81fq1 301 24 problem problem NN cord-013590-pkm81fq1 301 25 must must MD cord-013590-pkm81fq1 301 26 exist exist VB cord-013590-pkm81fq1 301 27 ( ( -LRB- cord-013590-pkm81fq1 301 28 Fig fig NN cord-013590-pkm81fq1 301 29 . . . cord-013590-pkm81fq1 301 30 1 1 CD cord-013590-pkm81fq1 301 31 ) ) -RRB- cord-013590-pkm81fq1 301 32 . . . cord-013590-pkm81fq1 302 1 One one CD cord-013590-pkm81fq1 302 2 option option NN cord-013590-pkm81fq1 302 3 to to TO cord-013590-pkm81fq1 302 4 regulate regulate VB cord-013590-pkm81fq1 302 5 activation activation NN cord-013590-pkm81fq1 302 6 of of IN cord-013590-pkm81fq1 302 7 the the DT cord-013590-pkm81fq1 302 8 γδ γδ NN cord-013590-pkm81fq1 303 1 TCR TCR NNP cord-013590-pkm81fq1 303 2 is be VBZ cord-013590-pkm81fq1 303 3 to to TO cord-013590-pkm81fq1 303 4 induce induce VB cord-013590-pkm81fq1 303 5 tissue tissue NN cord-013590-pkm81fq1 303 6 - - HYPH cord-013590-pkm81fq1 303 7 specific specific JJ cord-013590-pkm81fq1 303 8 antigen antigen NN cord-013590-pkm81fq1 303 9 expression expression NN cord-013590-pkm81fq1 303 10 upon upon IN cord-013590-pkm81fq1 303 11 stress stress NN cord-013590-pkm81fq1 303 12 conditions condition NNS cord-013590-pkm81fq1 303 13 ( ( -LRB- cord-013590-pkm81fq1 303 14 Fig Fig NNP cord-013590-pkm81fq1 303 15 . . . cord-013590-pkm81fq1 303 16 1a 1a CD cord-013590-pkm81fq1 303 17 ) ) -RRB- cord-013590-pkm81fq1 303 18 . . . cord-013590-pkm81fq1 304 1 Examples example NNS cord-013590-pkm81fq1 304 2 of of IN cord-013590-pkm81fq1 304 3 antigens antigen NNS cord-013590-pkm81fq1 304 4 differentially differentially RB cord-013590-pkm81fq1 304 5 expressed express VBN cord-013590-pkm81fq1 304 6 at at IN cord-013590-pkm81fq1 304 7 the the DT cord-013590-pkm81fq1 304 8 cell cell NN cord-013590-pkm81fq1 304 9 surface surface NN cord-013590-pkm81fq1 304 10 are be VBP cord-013590-pkm81fq1 304 11 MICA MICA NNP cord-013590-pkm81fq1 304 12 / / SYM cord-013590-pkm81fq1 304 13 MICB MICB NNP cord-013590-pkm81fq1 304 14 , , , cord-013590-pkm81fq1 304 15 10 10 CD cord-013590-pkm81fq1 304 16 Annexin Annexin NNP cord-013590-pkm81fq1 304 17 A2 A2 NNP cord-013590-pkm81fq1 304 18 53 53 CD cord-013590-pkm81fq1 304 19 and and CC cord-013590-pkm81fq1 304 20 EphA2 EphA2 NNP cord-013590-pkm81fq1 304 21 54 54 CD cord-013590-pkm81fq1 304 22 in in IN cord-013590-pkm81fq1 304 23 humans human NNS cord-013590-pkm81fq1 304 24 , , , cord-013590-pkm81fq1 304 25 which which WDT cord-013590-pkm81fq1 304 26 were be VBD cord-013590-pkm81fq1 304 27 upregulated upregulate VBN cord-013590-pkm81fq1 304 28 upon upon IN cord-013590-pkm81fq1 304 29 CMV CMV NNP cord-013590-pkm81fq1 304 30 - - HYPH cord-013590-pkm81fq1 304 31 infections infection NNS cord-013590-pkm81fq1 304 32 , , , cord-013590-pkm81fq1 304 33 hypoxia hypoxia NN cord-013590-pkm81fq1 304 34 , , , cord-013590-pkm81fq1 304 35 heat heat NN cord-013590-pkm81fq1 304 36 shock shock NN cord-013590-pkm81fq1 304 37 and and CC cord-013590-pkm81fq1 304 38 metabolic metabolic JJ cord-013590-pkm81fq1 304 39 reprogramming reprogramming NN cord-013590-pkm81fq1 304 40 . . . cord-013590-pkm81fq1 305 1 In in IN cord-013590-pkm81fq1 305 2 mice mouse NNS cord-013590-pkm81fq1 305 3 , , , cord-013590-pkm81fq1 305 4 the the DT cord-013590-pkm81fq1 305 5 expression expression NN cord-013590-pkm81fq1 305 6 of of IN cord-013590-pkm81fq1 305 7 γδ γδ NNP cord-013590-pkm81fq1 305 8 TCR TCR NNP cord-013590-pkm81fq1 305 9 ligands ligand NNS cord-013590-pkm81fq1 305 10 T10 T10 NNP cord-013590-pkm81fq1 305 11 and and CC cord-013590-pkm81fq1 305 12 T22 T22 NNP cord-013590-pkm81fq1 305 13 was be VBD cord-013590-pkm81fq1 305 14 described describe VBN cord-013590-pkm81fq1 305 15 to to TO cord-013590-pkm81fq1 305 16 be be VB cord-013590-pkm81fq1 305 17 upregulated upregulate VBN cord-013590-pkm81fq1 305 18 upon upon IN cord-013590-pkm81fq1 305 19 antigenic antigenic JJ cord-013590-pkm81fq1 305 20 activation activation NN cord-013590-pkm81fq1 305 21 of of IN cord-013590-pkm81fq1 305 22 αβ αβ FW cord-013590-pkm81fq1 305 23 T t NN cord-013590-pkm81fq1 305 24 cells cell NNS cord-013590-pkm81fq1 305 25 . . . cord-013590-pkm81fq1 306 1 49 49 CD cord-013590-pkm81fq1 307 1 Furthermore furthermore RB cord-013590-pkm81fq1 307 2 , , , cord-013590-pkm81fq1 307 3 some some DT cord-013590-pkm81fq1 307 4 in in IN cord-013590-pkm81fq1 307 5 vitro vitro FW cord-013590-pkm81fq1 307 6 studies study NNS cord-013590-pkm81fq1 307 7 suggest suggest VBP cord-013590-pkm81fq1 307 8 that that IN cord-013590-pkm81fq1 307 9 the the DT cord-013590-pkm81fq1 307 10 yet yet RB cord-013590-pkm81fq1 307 11 unknown unknown JJ cord-013590-pkm81fq1 307 12 antigens antigen NNS cord-013590-pkm81fq1 307 13 for for IN cord-013590-pkm81fq1 307 14 the the DT cord-013590-pkm81fq1 307 15 respective respective NNS cord-013590-pkm81fq1 307 16 investigated investigate VBN cord-013590-pkm81fq1 307 17 γδ γδ IN cord-013590-pkm81fq1 307 18 TCRs tcr NNS cord-013590-pkm81fq1 307 19 in in IN cord-013590-pkm81fq1 307 20 Malaria Malaria NNP cord-013590-pkm81fq1 307 21 and and CC cord-013590-pkm81fq1 307 22 Listeria Listeria NNP cord-013590-pkm81fq1 307 23 - - HYPH cord-013590-pkm81fq1 307 24 infection infection NN cord-013590-pkm81fq1 307 25 can can MD cord-013590-pkm81fq1 307 26 already already RB cord-013590-pkm81fq1 307 27 be be VB cord-013590-pkm81fq1 307 28 recognized recognize VBN cord-013590-pkm81fq1 307 29 on on IN cord-013590-pkm81fq1 307 30 target target NN cord-013590-pkm81fq1 307 31 cells cell NNS cord-013590-pkm81fq1 307 32 prior prior RB cord-013590-pkm81fq1 307 33 to to IN cord-013590-pkm81fq1 307 34 any any DT cord-013590-pkm81fq1 307 35 stress stress NN cord-013590-pkm81fq1 307 36 stimulus stimulus NN cord-013590-pkm81fq1 307 37 and and CC cord-013590-pkm81fq1 307 38 that that IN cord-013590-pkm81fq1 307 39 the the DT cord-013590-pkm81fq1 307 40 γδ γδ NN cord-013590-pkm81fq1 307 41 TCR TCR NNP cord-013590-pkm81fq1 307 42 reactivity reactivity NN cord-013590-pkm81fq1 307 43 was be VBD cord-013590-pkm81fq1 307 44 increased increase VBN cord-013590-pkm81fq1 307 45 upon upon IN cord-013590-pkm81fq1 307 46 e.g. e.g. RB cord-013590-pkm81fq1 307 47 , , , cord-013590-pkm81fq1 307 48 infection infection NN cord-013590-pkm81fq1 307 49 . . . cord-013590-pkm81fq1 308 1 117 117 CD cord-013590-pkm81fq1 308 2 , , , cord-013590-pkm81fq1 308 3 118 118 CD cord-013590-pkm81fq1 309 1 Besides besides IN cord-013590-pkm81fq1 309 2 a a DT cord-013590-pkm81fq1 309 3 transcriptional transcriptional JJ cord-013590-pkm81fq1 309 4 and and CC cord-013590-pkm81fq1 309 5 translational translational JJ cord-013590-pkm81fq1 309 6 upregulation upregulation NN cord-013590-pkm81fq1 309 7 of of IN cord-013590-pkm81fq1 309 8 antigen antigen NN cord-013590-pkm81fq1 309 9 expression expression NN cord-013590-pkm81fq1 309 10 , , , cord-013590-pkm81fq1 309 11 differential differential JJ cord-013590-pkm81fq1 309 12 subcellular subcellular JJ cord-013590-pkm81fq1 309 13 localization localization NN cord-013590-pkm81fq1 309 14 of of IN cord-013590-pkm81fq1 309 15 otherwise otherwise RB cord-013590-pkm81fq1 309 16 intracellular intracellular JJ cord-013590-pkm81fq1 309 17 γδ γδ IN cord-013590-pkm81fq1 309 18 TCR TCR NNP cord-013590-pkm81fq1 309 19 ligands ligand NNS cord-013590-pkm81fq1 309 20 might may MD cord-013590-pkm81fq1 309 21 regulate regulate VB cord-013590-pkm81fq1 309 22 activation activation NN cord-013590-pkm81fq1 309 23 . . . cord-013590-pkm81fq1 310 1 This this DT cord-013590-pkm81fq1 310 2 has have VBZ cord-013590-pkm81fq1 310 3 been be VBN cord-013590-pkm81fq1 310 4 suggested suggest VBN cord-013590-pkm81fq1 310 5 for for IN cord-013590-pkm81fq1 310 6 hMSH2 hMSH2 NNP cord-013590-pkm81fq1 310 7 , , , cord-013590-pkm81fq1 310 8 an an DT cord-013590-pkm81fq1 310 9 otherwise otherwise RB cord-013590-pkm81fq1 310 10 nuclear nuclear JJ cord-013590-pkm81fq1 310 11 protein protein NN cord-013590-pkm81fq1 310 12 involved involve VBN cord-013590-pkm81fq1 310 13 in in IN cord-013590-pkm81fq1 310 14 DNA dna NN cord-013590-pkm81fq1 310 15 damage damage NN cord-013590-pkm81fq1 310 16 repair repair NN cord-013590-pkm81fq1 310 17 . . . cord-013590-pkm81fq1 311 1 55 55 CD cord-013590-pkm81fq1 312 1 Although although IN cord-013590-pkm81fq1 312 2 this this DT cord-013590-pkm81fq1 312 3 theory theory NN cord-013590-pkm81fq1 312 4 of of IN cord-013590-pkm81fq1 312 5 differential differential JJ cord-013590-pkm81fq1 312 6 expression expression NN cord-013590-pkm81fq1 312 7 of of IN cord-013590-pkm81fq1 312 8 γδ γδ NN cord-013590-pkm81fq1 313 1 TCR TCR NNP cord-013590-pkm81fq1 313 2 ligands ligand NNS cord-013590-pkm81fq1 313 3 seems seem VBZ cord-013590-pkm81fq1 313 4 quite quite RB cord-013590-pkm81fq1 313 5 compelling compelling JJ cord-013590-pkm81fq1 313 6 , , , cord-013590-pkm81fq1 313 7 it -PRON- PRP cord-013590-pkm81fq1 313 8 does do VBZ cord-013590-pkm81fq1 313 9 not not RB cord-013590-pkm81fq1 313 10 sufficiently sufficiently RB cord-013590-pkm81fq1 313 11 explain explain VB cord-013590-pkm81fq1 313 12 all all DT cord-013590-pkm81fq1 313 13 observations observation NNS cord-013590-pkm81fq1 313 14 made make VBN cord-013590-pkm81fq1 313 15 with with IN cord-013590-pkm81fq1 313 16 γδ γδ XX cord-013590-pkm81fq1 313 17 TCRs tcr NNS cord-013590-pkm81fq1 313 18 investigated investigate VBN cord-013590-pkm81fq1 313 19 for for IN cord-013590-pkm81fq1 313 20 their -PRON- PRP$ cord-013590-pkm81fq1 313 21 recognition recognition NN cord-013590-pkm81fq1 313 22 and and CC cord-013590-pkm81fq1 313 23 binding bind VBG cord-013590-pkm81fq1 313 24 behavior behavior NN cord-013590-pkm81fq1 313 25 . . . cord-013590-pkm81fq1 314 1 In in IN cord-013590-pkm81fq1 314 2 some some DT cord-013590-pkm81fq1 314 3 cases case NNS cord-013590-pkm81fq1 314 4 , , , cord-013590-pkm81fq1 314 5 the the DT cord-013590-pkm81fq1 314 6 expression expression NN cord-013590-pkm81fq1 314 7 of of IN cord-013590-pkm81fq1 314 8 the the DT cord-013590-pkm81fq1 314 9 recognized recognize VBN cord-013590-pkm81fq1 314 10 antigen antigen NN cord-013590-pkm81fq1 314 11 on on IN cord-013590-pkm81fq1 314 12 certain certain JJ cord-013590-pkm81fq1 314 13 target target NN cord-013590-pkm81fq1 314 14 cells cell NNS cord-013590-pkm81fq1 314 15 does do VBZ cord-013590-pkm81fq1 314 16 not not RB cord-013590-pkm81fq1 314 17 induce induce VB cord-013590-pkm81fq1 314 18 the the DT cord-013590-pkm81fq1 314 19 respective respective JJ cord-013590-pkm81fq1 314 20 γδ γδ XX cord-013590-pkm81fq1 315 1 TCR TCR NNP cord-013590-pkm81fq1 315 2 , , , cord-013590-pkm81fq1 315 3 e.g. e.g. RB cord-013590-pkm81fq1 315 4 , , , cord-013590-pkm81fq1 315 5 in in IN cord-013590-pkm81fq1 315 6 the the DT cord-013590-pkm81fq1 315 7 case case NN cord-013590-pkm81fq1 315 8 of of IN cord-013590-pkm81fq1 315 9 EPCR EPCR NNP cord-013590-pkm81fq1 315 10 , , , cord-013590-pkm81fq1 315 11 25 25 CD cord-013590-pkm81fq1 315 12 EphA2 EphA2 NNP cord-013590-pkm81fq1 315 13 54 54 CD cord-013590-pkm81fq1 315 14 and and CC cord-013590-pkm81fq1 315 15 the the DT cord-013590-pkm81fq1 315 16 MHC MHC NNP cord-013590-pkm81fq1 315 17 - - HYPH cord-013590-pkm81fq1 315 18 molecules molecule NNS cord-013590-pkm81fq1 315 19 I i NN cord-013590-pkm81fq1 315 20 - - HYPH cord-013590-pkm81fq1 315 21 E E NNP cord-013590-pkm81fq1 315 22 119 119 CD cord-013590-pkm81fq1 315 23 and and CC cord-013590-pkm81fq1 315 24 HLA HLA NNP cord-013590-pkm81fq1 315 25 - - HYPH cord-013590-pkm81fq1 315 26 A a NN cord-013590-pkm81fq1 316 1 * * NFP cord-013590-pkm81fq1 316 2 24:02 24:02 CD cord-013590-pkm81fq1 316 3 . . . cord-013590-pkm81fq1 316 4 23 23 CD cord-013590-pkm81fq1 317 1 Interestingly interestingly RB cord-013590-pkm81fq1 317 2 , , , cord-013590-pkm81fq1 317 3 although although IN cord-013590-pkm81fq1 317 4 identified identify VBN cord-013590-pkm81fq1 317 5 as as IN cord-013590-pkm81fq1 317 6 the the DT cord-013590-pkm81fq1 317 7 antigen antigen NN cord-013590-pkm81fq1 317 8 of of IN cord-013590-pkm81fq1 317 9 a a DT cord-013590-pkm81fq1 317 10 CMV CMV NNP cord-013590-pkm81fq1 317 11 - - HYPH cord-013590-pkm81fq1 317 12 reactive reactive JJ cord-013590-pkm81fq1 317 13 γδ γδ IN cord-013590-pkm81fq1 317 14 TCR TCR NNP cord-013590-pkm81fq1 317 15 , , , cord-013590-pkm81fq1 317 16 the the DT cord-013590-pkm81fq1 317 17 expression expression NN cord-013590-pkm81fq1 317 18 of of IN cord-013590-pkm81fq1 317 19 the the DT cord-013590-pkm81fq1 317 20 EPCR EPCR NNP cord-013590-pkm81fq1 317 21 is be VBZ cord-013590-pkm81fq1 317 22 unchanged unchanged JJ cord-013590-pkm81fq1 317 23 upon upon IN cord-013590-pkm81fq1 317 24 CMV CMV NNP cord-013590-pkm81fq1 317 25 infection infection NN cord-013590-pkm81fq1 317 26 . . . cord-013590-pkm81fq1 318 1 Put put VB cord-013590-pkm81fq1 318 2 together together RB cord-013590-pkm81fq1 318 3 , , , cord-013590-pkm81fq1 318 4 these these DT cord-013590-pkm81fq1 318 5 observations observation NNS cord-013590-pkm81fq1 318 6 indicate indicate VBP cord-013590-pkm81fq1 318 7 that that IN cord-013590-pkm81fq1 318 8 either either DT cord-013590-pkm81fq1 318 9 binding binding NN cord-013590-pkm81fq1 318 10 of of IN cord-013590-pkm81fq1 318 11 the the DT cord-013590-pkm81fq1 318 12 γδ γδ NN cord-013590-pkm81fq1 318 13 TCR TCR NNP cord-013590-pkm81fq1 318 14 to to IN cord-013590-pkm81fq1 318 15 its -PRON- PRP$ cord-013590-pkm81fq1 318 16 cognate cognate JJ cord-013590-pkm81fq1 318 17 antigen antigen NN cord-013590-pkm81fq1 318 18 is be VBZ cord-013590-pkm81fq1 318 19 not not RB cord-013590-pkm81fq1 318 20 always always RB cord-013590-pkm81fq1 318 21 sufficient sufficient JJ cord-013590-pkm81fq1 318 22 for for IN cord-013590-pkm81fq1 318 23 its -PRON- PRP$ cord-013590-pkm81fq1 318 24 activation activation NN cord-013590-pkm81fq1 318 25 and and CC cord-013590-pkm81fq1 318 26 that that IN cord-013590-pkm81fq1 318 27 additional additional JJ cord-013590-pkm81fq1 318 28 signals signal NNS cord-013590-pkm81fq1 318 29 or or CC cord-013590-pkm81fq1 318 30 molecular molecular JJ cord-013590-pkm81fq1 318 31 changes change NNS cord-013590-pkm81fq1 318 32 in in IN cord-013590-pkm81fq1 318 33 the the DT cord-013590-pkm81fq1 318 34 antigen antigen NN cord-013590-pkm81fq1 318 35 itself -PRON- PRP cord-013590-pkm81fq1 318 36 are be VBP cord-013590-pkm81fq1 318 37 necessary necessary JJ cord-013590-pkm81fq1 318 38 . . . cord-013590-pkm81fq1 319 1 Ligand ligand NN cord-013590-pkm81fq1 319 2 recognition recognition NN cord-013590-pkm81fq1 319 3 by by IN cord-013590-pkm81fq1 319 4 the the DT cord-013590-pkm81fq1 319 5 γδ γδ NNP cord-013590-pkm81fq1 319 6 TCR TCR NNP cord-013590-pkm81fq1 319 7 and and CC cord-013590-pkm81fq1 319 8 discrimination discrimination NN cord-013590-pkm81fq1 319 9 between between IN cord-013590-pkm81fq1 319 10 homeostasis homeostasis NN cord-013590-pkm81fq1 319 11 . . . cord-013590-pkm81fq1 319 12 . . . cord-013590-pkm81fq1 319 13 . . . cord-013590-pkm81fq1 320 1 M M NNP cord-013590-pkm81fq1 320 2 Deseke Deseke NNP cord-013590-pkm81fq1 320 3 and and CC cord-013590-pkm81fq1 320 4 I -PRON- PRP cord-013590-pkm81fq1 320 5 Prinz Prinz NNP cord-013590-pkm81fq1 320 6 Fig Fig NNP cord-013590-pkm81fq1 320 7 . . . cord-013590-pkm81fq1 321 1 1 1 LS cord-013590-pkm81fq1 321 2 Mechanisms mechanism NNS cord-013590-pkm81fq1 321 3 for for IN cord-013590-pkm81fq1 321 4 the the DT cord-013590-pkm81fq1 321 5 discrimination discrimination NN cord-013590-pkm81fq1 321 6 of of IN cord-013590-pkm81fq1 321 7 health health NN cord-013590-pkm81fq1 321 8 and and CC cord-013590-pkm81fq1 321 9 stress stress NN cord-013590-pkm81fq1 321 10 conditions condition NNS cord-013590-pkm81fq1 321 11 via via IN cord-013590-pkm81fq1 321 12 the the DT cord-013590-pkm81fq1 321 13 γδ γδ NN cord-013590-pkm81fq1 321 14 TCR TCR NNP cord-013590-pkm81fq1 321 15 . . . cord-013590-pkm81fq1 322 1 a a DT cord-013590-pkm81fq1 322 2 The the DT cord-013590-pkm81fq1 322 3 putative putative JJ cord-013590-pkm81fq1 322 4 γδ γδ NN cord-013590-pkm81fq1 323 1 TCR TCR NNP cord-013590-pkm81fq1 323 2 ligand ligand NN cord-013590-pkm81fq1 323 3 might may MD cord-013590-pkm81fq1 323 4 be be VB cord-013590-pkm81fq1 323 5 differentially differentially RB cord-013590-pkm81fq1 323 6 expressed express VBN cord-013590-pkm81fq1 323 7 depending depend VBG cord-013590-pkm81fq1 323 8 on on IN cord-013590-pkm81fq1 323 9 the the DT cord-013590-pkm81fq1 323 10 stress stress NN cord-013590-pkm81fq1 323 11 level level NN cord-013590-pkm81fq1 323 12 of of IN cord-013590-pkm81fq1 323 13 the the DT cord-013590-pkm81fq1 323 14 cell cell NN cord-013590-pkm81fq1 323 15 . . . cord-013590-pkm81fq1 324 1 In in IN cord-013590-pkm81fq1 324 2 the the DT cord-013590-pkm81fq1 324 3 case case NN cord-013590-pkm81fq1 324 4 of of IN cord-013590-pkm81fq1 324 5 stress stress NN cord-013590-pkm81fq1 324 6 - - HYPH cord-013590-pkm81fq1 324 7 induced induce VBN cord-013590-pkm81fq1 324 8 antigens antigen NNS cord-013590-pkm81fq1 324 9 such such JJ cord-013590-pkm81fq1 324 10 as as IN cord-013590-pkm81fq1 324 11 Annexin Annexin NNP cord-013590-pkm81fq1 324 12 A2 A2 NNP cord-013590-pkm81fq1 324 13 or or CC cord-013590-pkm81fq1 324 14 MICA MICA NNP cord-013590-pkm81fq1 324 15 / / SYM cord-013590-pkm81fq1 324 16 MICB MICB NNP cord-013590-pkm81fq1 325 1 this this DT cord-013590-pkm81fq1 325 2 would would MD cord-013590-pkm81fq1 325 3 mean mean VB cord-013590-pkm81fq1 325 4 an an DT cord-013590-pkm81fq1 325 5 upregulation upregulation NN cord-013590-pkm81fq1 325 6 whereas whereas IN cord-013590-pkm81fq1 325 7 BTNL BTNL NNP cord-013590-pkm81fq1 325 8 molecules molecule NNS cord-013590-pkm81fq1 325 9 might may MD cord-013590-pkm81fq1 325 10 be be VB cord-013590-pkm81fq1 325 11 downregulated downregulate VBN cord-013590-pkm81fq1 325 12 allowing allow VBG cord-013590-pkm81fq1 325 13 for for IN cord-013590-pkm81fq1 325 14 γδ γδ XX cord-013590-pkm81fq1 326 1 TCR TCR NNP cord-013590-pkm81fq1 326 2 activation activation NN cord-013590-pkm81fq1 326 3 via via IN cord-013590-pkm81fq1 326 4 the the DT cord-013590-pkm81fq1 326 5 CDR3 CDR3 NNP cord-013590-pkm81fq1 326 6 . . . cord-013590-pkm81fq1 327 1 b b LS cord-013590-pkm81fq1 327 2 Co co JJ cord-013590-pkm81fq1 327 3 - - JJ cord-013590-pkm81fq1 327 4 stimulatory stimulatory JJ cord-013590-pkm81fq1 327 5 molecules molecule NNS cord-013590-pkm81fq1 327 6 such such JJ cord-013590-pkm81fq1 327 7 as as IN cord-013590-pkm81fq1 327 8 CD27 CD27 NNP cord-013590-pkm81fq1 327 9 or or CC cord-013590-pkm81fq1 327 10 JAML JAML NNP cord-013590-pkm81fq1 327 11 might may MD cord-013590-pkm81fq1 327 12 be be VB cord-013590-pkm81fq1 327 13 required require VBN cord-013590-pkm81fq1 327 14 for for IN cord-013590-pkm81fq1 327 15 full full JJ cord-013590-pkm81fq1 327 16 activation activation NN cord-013590-pkm81fq1 327 17 of of IN cord-013590-pkm81fq1 327 18 the the DT cord-013590-pkm81fq1 327 19 γδ γδ NNP cord-013590-pkm81fq1 327 20 TCR TCR NNP cord-013590-pkm81fq1 327 21 and and CC cord-013590-pkm81fq1 327 22 their -PRON- PRP$ cord-013590-pkm81fq1 327 23 upregulation upregulation NN cord-013590-pkm81fq1 327 24 might may MD cord-013590-pkm81fq1 327 25 be be VB cord-013590-pkm81fq1 327 26 triggered trigger VBN cord-013590-pkm81fq1 327 27 by by IN cord-013590-pkm81fq1 327 28 stress stress NN cord-013590-pkm81fq1 327 29 conditions condition NNS cord-013590-pkm81fq1 327 30 . . . cord-013590-pkm81fq1 328 1 c c LS cord-013590-pkm81fq1 328 2 Changes change NNS cord-013590-pkm81fq1 328 3 in in IN cord-013590-pkm81fq1 328 4 the the DT cord-013590-pkm81fq1 328 5 conformation conformation NN cord-013590-pkm81fq1 328 6 of of IN cord-013590-pkm81fq1 328 7 the the DT cord-013590-pkm81fq1 328 8 ligand ligand NN cord-013590-pkm81fq1 328 9 might may MD cord-013590-pkm81fq1 328 10 increase increase VB cord-013590-pkm81fq1 328 11 the the DT cord-013590-pkm81fq1 328 12 accessibility accessibility NN cord-013590-pkm81fq1 328 13 of of IN cord-013590-pkm81fq1 328 14 a a DT cord-013590-pkm81fq1 328 15 particular particular JJ cord-013590-pkm81fq1 328 16 γδ γδ IN cord-013590-pkm81fq1 328 17 TCR TCR NNP cord-013590-pkm81fq1 328 18 binding binding NN cord-013590-pkm81fq1 328 19 domain domain NN cord-013590-pkm81fq1 328 20 . . . cord-013590-pkm81fq1 329 1 BTN3A1 BTN3A1 NNP cord-013590-pkm81fq1 329 2 for for IN cord-013590-pkm81fq1 329 3 example example NN cord-013590-pkm81fq1 329 4 undergoes undergo VBZ cord-013590-pkm81fq1 329 5 conformational conformational JJ cord-013590-pkm81fq1 329 6 changes change NNS cord-013590-pkm81fq1 329 7 upon upon IN cord-013590-pkm81fq1 329 8 p p NN cord-013590-pkm81fq1 329 9 - - : cord-013590-pkm81fq1 329 10 Ag Ag NNP cord-013590-pkm81fq1 329 11 binding binding NN cord-013590-pkm81fq1 329 12 . . . cord-013590-pkm81fq1 330 1 d d NNP cord-013590-pkm81fq1 330 2 Multimerization Multimerization NNP cord-013590-pkm81fq1 330 3 or or CC cord-013590-pkm81fq1 330 4 monomerization monomerization NN cord-013590-pkm81fq1 330 5 of of IN cord-013590-pkm81fq1 330 6 the the DT cord-013590-pkm81fq1 330 7 respective respective JJ cord-013590-pkm81fq1 330 8 ligand ligand NN cord-013590-pkm81fq1 330 9 can can MD cord-013590-pkm81fq1 330 10 be be VB cord-013590-pkm81fq1 330 11 triggers trigger NNS cord-013590-pkm81fq1 330 12 for for IN cord-013590-pkm81fq1 330 13 γδ γδ XX cord-013590-pkm81fq1 331 1 TCR TCR NNP cord-013590-pkm81fq1 331 2 as as IN cord-013590-pkm81fq1 331 3 in in IN cord-013590-pkm81fq1 331 4 the the DT cord-013590-pkm81fq1 331 5 case case NN cord-013590-pkm81fq1 331 6 of of IN cord-013590-pkm81fq1 331 7 the the DT cord-013590-pkm81fq1 331 8 HLAmolecule HLAmolecule NNP cord-013590-pkm81fq1 331 9 A*24:02 A*24:02 NNP cord-013590-pkm81fq1 331 10 . . . cord-013590-pkm81fq1 332 1 e e LS cord-013590-pkm81fq1 332 2 Glycosylation glycosylation NN cord-013590-pkm81fq1 332 3 patterns pattern NNS cord-013590-pkm81fq1 332 4 are be VBP cord-013590-pkm81fq1 332 5 modified modify VBN cord-013590-pkm81fq1 332 6 upon upon IN cord-013590-pkm81fq1 332 7 infections infection NNS cord-013590-pkm81fq1 332 8 or or CC cord-013590-pkm81fq1 332 9 tumor tumor NN cord-013590-pkm81fq1 332 10 development development NN cord-013590-pkm81fq1 332 11 . . . cord-013590-pkm81fq1 333 1 These these DT cord-013590-pkm81fq1 333 2 changes change NNS cord-013590-pkm81fq1 333 3 in in IN cord-013590-pkm81fq1 333 4 post post JJ cord-013590-pkm81fq1 333 5 - - JJ cord-013590-pkm81fq1 333 6 translational translational JJ cord-013590-pkm81fq1 333 7 modifications modification NNS cord-013590-pkm81fq1 333 8 might may MD cord-013590-pkm81fq1 333 9 lead lead VB cord-013590-pkm81fq1 333 10 to to IN cord-013590-pkm81fq1 333 11 different different JJ cord-013590-pkm81fq1 333 12 outcomes outcome NNS cord-013590-pkm81fq1 333 13 of of IN cord-013590-pkm81fq1 333 14 γδ γδ IN cord-013590-pkm81fq1 333 15 TCR TCR NNP cord-013590-pkm81fq1 333 16 interaction interaction NN cord-013590-pkm81fq1 333 17 with with IN cord-013590-pkm81fq1 333 18 the the DT cord-013590-pkm81fq1 333 19 same same JJ cord-013590-pkm81fq1 333 20 ligand ligand NN cord-013590-pkm81fq1 333 21 with with IN cord-013590-pkm81fq1 333 22 different different JJ cord-013590-pkm81fq1 333 23 glycan glycan NN cord-013590-pkm81fq1 333 24 residues residue NNS cord-013590-pkm81fq1 333 25 on on IN cord-013590-pkm81fq1 333 26 the the DT cord-013590-pkm81fq1 333 27 extracellular extracellular JJ cord-013590-pkm81fq1 333 28 domain domain NN cord-013590-pkm81fq1 334 1 Ligand ligand NN cord-013590-pkm81fq1 334 2 recognition recognition NN cord-013590-pkm81fq1 334 3 by by IN cord-013590-pkm81fq1 334 4 the the DT cord-013590-pkm81fq1 334 5 γδ γδ NNP cord-013590-pkm81fq1 334 6 TCR TCR NNP cord-013590-pkm81fq1 334 7 and and CC cord-013590-pkm81fq1 334 8 discrimination discrimination NN cord-013590-pkm81fq1 334 9 between between IN cord-013590-pkm81fq1 334 10 homeostasis homeostasis NN cord-013590-pkm81fq1 334 11 . . . cord-013590-pkm81fq1 334 12 . . . cord-013590-pkm81fq1 334 13 . . . cord-013590-pkm81fq1 335 1 Like like IN cord-013590-pkm81fq1 335 2 αβ αβ NN cord-013590-pkm81fq1 335 3 T t NN cord-013590-pkm81fq1 335 4 cells cell NNS cord-013590-pkm81fq1 335 5 which which WDT cord-013590-pkm81fq1 335 6 rely rely VBP cord-013590-pkm81fq1 335 7 on on IN cord-013590-pkm81fq1 335 8 co co NN cord-013590-pkm81fq1 335 9 - - NN cord-013590-pkm81fq1 335 10 receptor receptor NN cord-013590-pkm81fq1 335 11 and and CC cord-013590-pkm81fq1 335 12 co co JJ cord-013590-pkm81fq1 335 13 - - JJ cord-013590-pkm81fq1 335 14 stimulatory stimulatory JJ cord-013590-pkm81fq1 335 15 signals signal NNS cord-013590-pkm81fq1 335 16 to to TO cord-013590-pkm81fq1 335 17 regulate regulate VB cord-013590-pkm81fq1 335 18 their -PRON- PRP$ cord-013590-pkm81fq1 335 19 response response NN cord-013590-pkm81fq1 335 20 via via IN cord-013590-pkm81fq1 335 21 e.g. e.g. RB cord-013590-pkm81fq1 335 22 , , , cord-013590-pkm81fq1 335 23 CD4 CD4 NNP cord-013590-pkm81fq1 335 24 / / SYM cord-013590-pkm81fq1 335 25 CD8 CD8 NNP cord-013590-pkm81fq1 335 26 and and CC cord-013590-pkm81fq1 335 27 CD28 CD28 NNP cord-013590-pkm81fq1 335 28 , , , cord-013590-pkm81fq1 335 29 γδ γδ CC cord-013590-pkm81fq1 335 30 TCRs tcr NNS cord-013590-pkm81fq1 335 31 might may MD cord-013590-pkm81fq1 335 32 also also RB cord-013590-pkm81fq1 335 33 require require VB cord-013590-pkm81fq1 335 34 certain certain JJ cord-013590-pkm81fq1 335 35 co co NNS cord-013590-pkm81fq1 335 36 - - NNS cord-013590-pkm81fq1 335 37 receptors receptor NNS cord-013590-pkm81fq1 335 38 for for IN cord-013590-pkm81fq1 335 39 full full JJ cord-013590-pkm81fq1 335 40 activation activation NN cord-013590-pkm81fq1 335 41 ( ( -LRB- cord-013590-pkm81fq1 335 42 Fig fig NN cord-013590-pkm81fq1 335 43 . . . cord-013590-pkm81fq1 335 44 1b 1b CD cord-013590-pkm81fq1 335 45 ) ) -RRB- cord-013590-pkm81fq1 335 46 . . . cord-013590-pkm81fq1 336 1 Butyrophilins Butyrophilins NNP cord-013590-pkm81fq1 336 2 and and CC cord-013590-pkm81fq1 336 3 the the DT cord-013590-pkm81fq1 336 4 butyrophilin butyrophilin NN cord-013590-pkm81fq1 336 5 - - HYPH cord-013590-pkm81fq1 336 6 like like JJ cord-013590-pkm81fq1 336 7 molecules molecule NNS cord-013590-pkm81fq1 336 8 Btnl/ btnl/ VBP cord-013590-pkm81fq1 336 9 BTNL BTNL NNP cord-013590-pkm81fq1 336 10 might may MD cord-013590-pkm81fq1 336 11 represent represent VB cord-013590-pkm81fq1 336 12 candidates candidate NNS cord-013590-pkm81fq1 336 13 for for IN cord-013590-pkm81fq1 336 14 such such PDT cord-013590-pkm81fq1 336 15 a a DT cord-013590-pkm81fq1 336 16 regulatory regulatory JJ cord-013590-pkm81fq1 336 17 function function NN cord-013590-pkm81fq1 336 18 . . . cord-013590-pkm81fq1 337 1 As as IN cord-013590-pkm81fq1 337 2 they -PRON- PRP cord-013590-pkm81fq1 337 3 are be VBP cord-013590-pkm81fq1 337 4 binding bind VBG cord-013590-pkm81fq1 337 5 to to IN cord-013590-pkm81fq1 337 6 germline germline NN cord-013590-pkm81fq1 337 7 - - HYPH cord-013590-pkm81fq1 337 8 encoded encode VBN cord-013590-pkm81fq1 337 9 regions region NNS cord-013590-pkm81fq1 337 10 in in IN cord-013590-pkm81fq1 337 11 the the DT cord-013590-pkm81fq1 337 12 Vγ Vγ NNP cord-013590-pkm81fq1 337 13 - - HYPH cord-013590-pkm81fq1 337 14 chain chain NN cord-013590-pkm81fq1 337 15 distinct distinct JJ cord-013590-pkm81fq1 337 16 of of IN cord-013590-pkm81fq1 337 17 the the DT cord-013590-pkm81fq1 337 18 CDR3 CDR3 NNP cord-013590-pkm81fq1 337 19 , , , cord-013590-pkm81fq1 337 20 they -PRON- PRP cord-013590-pkm81fq1 337 21 could could MD cord-013590-pkm81fq1 337 22 exert exert VB cord-013590-pkm81fq1 337 23 co co JJ cord-013590-pkm81fq1 337 24 - - JJ cord-013590-pkm81fq1 337 25 receptor receptor JJ cord-013590-pkm81fq1 337 26 functions function NNS cord-013590-pkm81fq1 337 27 in in IN cord-013590-pkm81fq1 337 28 addition addition NN cord-013590-pkm81fq1 337 29 to to IN cord-013590-pkm81fq1 337 30 the the DT cord-013590-pkm81fq1 337 31 clonotype clonotype NN cord-013590-pkm81fq1 337 32 - - HYPH cord-013590-pkm81fq1 337 33 specific specific JJ cord-013590-pkm81fq1 337 34 antigens antigen NNS cord-013590-pkm81fq1 337 35 . . . cord-013590-pkm81fq1 338 1 However however RB cord-013590-pkm81fq1 338 2 , , , cord-013590-pkm81fq1 338 3 binding bind VBG cord-013590-pkm81fq1 338 4 of of IN cord-013590-pkm81fq1 338 5 BTNL3 BTNL3 NNS cord-013590-pkm81fq1 338 6 to to IN cord-013590-pkm81fq1 338 7 human human JJ cord-013590-pkm81fq1 338 8 LES LES NNP cord-013590-pkm81fq1 338 9 TCR TCR NNP cord-013590-pkm81fq1 338 10 ( ( -LRB- cord-013590-pkm81fq1 338 11 Vγ4Vδ5 Vγ4Vδ5 NNP cord-013590-pkm81fq1 338 12 ) ) -RRB- cord-013590-pkm81fq1 338 13 was be VBD cord-013590-pkm81fq1 338 14 reported report VBN cord-013590-pkm81fq1 338 15 to to TO cord-013590-pkm81fq1 338 16 inhibit inhibit VB cord-013590-pkm81fq1 338 17 the the DT cord-013590-pkm81fq1 338 18 interaction interaction NN cord-013590-pkm81fq1 338 19 with with IN cord-013590-pkm81fq1 338 20 EPCR EPCR NNP cord-013590-pkm81fq1 338 21 via via IN cord-013590-pkm81fq1 338 22 the the DT cord-013590-pkm81fq1 338 23 CDR3 CDR3 NNP cord-013590-pkm81fq1 338 24 , , , cord-013590-pkm81fq1 338 25 indicating indicate VBG cord-013590-pkm81fq1 338 26 that that IN cord-013590-pkm81fq1 338 27 simultaneous simultaneous JJ cord-013590-pkm81fq1 338 28 interaction interaction NN cord-013590-pkm81fq1 338 29 with with IN cord-013590-pkm81fq1 338 30 BTNLs btnl NNS cord-013590-pkm81fq1 338 31 and and CC cord-013590-pkm81fq1 338 32 antigen antigen NN cord-013590-pkm81fq1 338 33 is be VBZ cord-013590-pkm81fq1 338 34 impossible impossible JJ cord-013590-pkm81fq1 338 35 . . . cord-013590-pkm81fq1 339 1 114 114 CD cord-013590-pkm81fq1 340 1 Therefore therefore RB cord-013590-pkm81fq1 340 2 , , , cord-013590-pkm81fq1 340 3 BTNLs BTNLs NNPS cord-013590-pkm81fq1 340 4 might may MD cord-013590-pkm81fq1 340 5 not not RB cord-013590-pkm81fq1 340 6 function function VB cord-013590-pkm81fq1 340 7 as as IN cord-013590-pkm81fq1 340 8 classical classical JJ cord-013590-pkm81fq1 340 9 co co NNS cord-013590-pkm81fq1 340 10 - - NNS cord-013590-pkm81fq1 340 11 receptors receptor NNS cord-013590-pkm81fq1 340 12 acting act VBG cord-013590-pkm81fq1 340 13 in in IN cord-013590-pkm81fq1 340 14 parallel parallel NN cord-013590-pkm81fq1 340 15 to to IN cord-013590-pkm81fq1 340 16 TCR TCR NNP cord-013590-pkm81fq1 340 17 signaling signal VBG cord-013590-pkm81fq1 340 18 but but CC cord-013590-pkm81fq1 340 19 rather rather RB cord-013590-pkm81fq1 340 20 confer confer VB cord-013590-pkm81fq1 340 21 signals signal NNS cord-013590-pkm81fq1 340 22 of of IN cord-013590-pkm81fq1 340 23 normality normality NN cord-013590-pkm81fq1 340 24 before before IN cord-013590-pkm81fq1 340 25 the the DT cord-013590-pkm81fq1 340 26 actual actual JJ cord-013590-pkm81fq1 340 27 γδ γδ NN cord-013590-pkm81fq1 340 28 TCR TCR NNP cord-013590-pkm81fq1 340 29 activation activation NN cord-013590-pkm81fq1 340 30 . . . cord-013590-pkm81fq1 341 1 Upon upon IN cord-013590-pkm81fq1 341 2 stress stress NN cord-013590-pkm81fq1 341 3 conditions condition NNS cord-013590-pkm81fq1 341 4 such such JJ cord-013590-pkm81fq1 341 5 as as IN cord-013590-pkm81fq1 341 6 an an DT cord-013590-pkm81fq1 341 7 infection infection NN cord-013590-pkm81fq1 341 8 , , , cord-013590-pkm81fq1 341 9 BTNLs btnl NNS cord-013590-pkm81fq1 341 10 could could MD cord-013590-pkm81fq1 341 11 be be VB cord-013590-pkm81fq1 341 12 downregulated downregulate VBN cord-013590-pkm81fq1 341 13 allowing allow VBG cord-013590-pkm81fq1 341 14 for for IN cord-013590-pkm81fq1 341 15 the the DT cord-013590-pkm81fq1 341 16 subsequent subsequent JJ cord-013590-pkm81fq1 341 17 recognition recognition NN cord-013590-pkm81fq1 341 18 of of IN cord-013590-pkm81fq1 341 19 stress stress NN cord-013590-pkm81fq1 341 20 - - HYPH cord-013590-pkm81fq1 341 21 induced induce VBN cord-013590-pkm81fq1 341 22 ligands ligand NNS cord-013590-pkm81fq1 341 23 17 17 CD cord-013590-pkm81fq1 342 1 ( ( -LRB- cord-013590-pkm81fq1 342 2 Fig Fig NNP cord-013590-pkm81fq1 342 3 . . . cord-013590-pkm81fq1 342 4 1a 1a CD cord-013590-pkm81fq1 342 5 ) ) -RRB- cord-013590-pkm81fq1 342 6 . . . cord-013590-pkm81fq1 343 1 Inline inline VB cord-013590-pkm81fq1 343 2 with with IN cord-013590-pkm81fq1 343 3 this this DT cord-013590-pkm81fq1 343 4 is be VBZ cord-013590-pkm81fq1 343 5 the the DT cord-013590-pkm81fq1 343 6 observation observation NN cord-013590-pkm81fq1 343 7 that that IN cord-013590-pkm81fq1 343 8 the the DT cord-013590-pkm81fq1 343 9 BTNL BTNL NNP cord-013590-pkm81fq1 343 10 expression expression NN cord-013590-pkm81fq1 343 11 is be VBZ cord-013590-pkm81fq1 343 12 altered alter VBN cord-013590-pkm81fq1 343 13 upon upon IN cord-013590-pkm81fq1 343 14 intestinal intestinal JJ cord-013590-pkm81fq1 343 15 inflammation inflammation NN cord-013590-pkm81fq1 343 16 and and CC cord-013590-pkm81fq1 343 17 colon colon NN cord-013590-pkm81fq1 343 18 cancer cancer NN cord-013590-pkm81fq1 343 19 in in IN cord-013590-pkm81fq1 343 20 humans human NNS cord-013590-pkm81fq1 343 21 and and CC cord-013590-pkm81fq1 343 22 mice mouse NNS cord-013590-pkm81fq1 343 23 . . . cord-013590-pkm81fq1 344 1 120 120 CD cord-013590-pkm81fq1 344 2 , , , cord-013590-pkm81fq1 344 3 121 121 CD cord-013590-pkm81fq1 344 4 Evidence evidence NN cord-013590-pkm81fq1 344 5 for for IN cord-013590-pkm81fq1 344 6 this this DT cord-013590-pkm81fq1 344 7 regulatory regulatory JJ cord-013590-pkm81fq1 344 8 role role NN cord-013590-pkm81fq1 344 9 of of IN cord-013590-pkm81fq1 344 10 BTNLs btnl NNS cord-013590-pkm81fq1 344 11 in in IN cord-013590-pkm81fq1 344 12 γδ γδ XX cord-013590-pkm81fq1 345 1 TCR TCR NNP cord-013590-pkm81fq1 345 2 activation activation NN cord-013590-pkm81fq1 345 3 is be VBZ cord-013590-pkm81fq1 345 4 however however RB cord-013590-pkm81fq1 345 5 still still RB cord-013590-pkm81fq1 345 6 missing miss VBG cord-013590-pkm81fq1 346 1 and and CC cord-013590-pkm81fq1 346 2 it -PRON- PRP cord-013590-pkm81fq1 346 3 remains remain VBZ cord-013590-pkm81fq1 346 4 therefore therefore RB cord-013590-pkm81fq1 346 5 purely purely RB cord-013590-pkm81fq1 346 6 hypothetical hypothetical JJ cord-013590-pkm81fq1 346 7 . . . cord-013590-pkm81fq1 347 1 A a DT cord-013590-pkm81fq1 347 2 wide wide JJ cord-013590-pkm81fq1 347 3 range range NN cord-013590-pkm81fq1 347 4 of of IN cord-013590-pkm81fq1 347 5 co co JJ cord-013590-pkm81fq1 347 6 - - JJ cord-013590-pkm81fq1 347 7 stimulatory stimulatory JJ cord-013590-pkm81fq1 347 8 molecules molecule NNS cord-013590-pkm81fq1 347 9 required require VBN cord-013590-pkm81fq1 347 10 for for IN cord-013590-pkm81fq1 347 11 full full JJ cord-013590-pkm81fq1 347 12 TCRdependent tcrdependent NN cord-013590-pkm81fq1 347 13 γδ γδ IN cord-013590-pkm81fq1 347 14 T t NN cord-013590-pkm81fq1 347 15 - - HYPH cord-013590-pkm81fq1 347 16 cell cell NN cord-013590-pkm81fq1 347 17 activation activation NN cord-013590-pkm81fq1 347 18 have have VBP cord-013590-pkm81fq1 347 19 been be VBN cord-013590-pkm81fq1 347 20 described describe VBN cord-013590-pkm81fq1 347 21 . . . cord-013590-pkm81fq1 348 1 122 122 CD cord-013590-pkm81fq1 349 1 These these DT cord-013590-pkm81fq1 349 2 comprise comprise VBP cord-013590-pkm81fq1 349 3 amongst amongst IN cord-013590-pkm81fq1 349 4 others other NNS cord-013590-pkm81fq1 349 5 CD2 CD2 NNP cord-013590-pkm81fq1 349 6 , , , cord-013590-pkm81fq1 349 7 123,124 123,124 CD cord-013590-pkm81fq1 349 8 CD28 CD28 NNP cord-013590-pkm81fq1 349 9 , , , cord-013590-pkm81fq1 349 10 125 125 CD cord-013590-pkm81fq1 349 11 , , , cord-013590-pkm81fq1 349 12 126 126 CD cord-013590-pkm81fq1 349 13 CD27 CD27 NNP cord-013590-pkm81fq1 349 14 in in IN cord-013590-pkm81fq1 349 15 the the DT cord-013590-pkm81fq1 349 16 p p NNP cord-013590-pkm81fq1 349 17 - - HYPH cord-013590-pkm81fq1 349 18 Ag Ag NNP cord-013590-pkm81fq1 349 19 - - HYPH cord-013590-pkm81fq1 349 20 dependent dependent JJ cord-013590-pkm81fq1 349 21 stimulation stimulation NN cord-013590-pkm81fq1 349 22 of of IN cord-013590-pkm81fq1 349 23 Vγ9Vδ2 Vγ9Vδ2 NNS cord-013590-pkm81fq1 349 24 + + CC cord-013590-pkm81fq1 349 25 γδ γδ CC cord-013590-pkm81fq1 349 26 T t NN cord-013590-pkm81fq1 349 27 cells cell NNS cord-013590-pkm81fq1 349 28 127 127 CD cord-013590-pkm81fq1 349 29 and and CC cord-013590-pkm81fq1 349 30 JAML JAML NNP cord-013590-pkm81fq1 349 31 in in IN cord-013590-pkm81fq1 349 32 the the DT cord-013590-pkm81fq1 349 33 activation activation NN cord-013590-pkm81fq1 349 34 of of IN cord-013590-pkm81fq1 349 35 murine murine JJ cord-013590-pkm81fq1 349 36 DETCs detc NNS cord-013590-pkm81fq1 349 37 . . . cord-013590-pkm81fq1 350 1 128 128 CD cord-013590-pkm81fq1 351 1 Besides besides RB cord-013590-pkm81fq1 351 2 , , , cord-013590-pkm81fq1 351 3 CD8α CD8α NNP cord-013590-pkm81fq1 351 4 has have VBZ cord-013590-pkm81fq1 351 5 been be VBN cord-013590-pkm81fq1 351 6 shown show VBN cord-013590-pkm81fq1 351 7 to to TO cord-013590-pkm81fq1 351 8 increase increase VB cord-013590-pkm81fq1 351 9 the the DT cord-013590-pkm81fq1 351 10 reactivity reactivity NN cord-013590-pkm81fq1 351 11 to to IN cord-013590-pkm81fq1 351 12 cancer cancer NN cord-013590-pkm81fq1 351 13 cells cell NNS cord-013590-pkm81fq1 351 14 of of IN cord-013590-pkm81fq1 351 15 some some DT cord-013590-pkm81fq1 351 16 Vδ1 vδ1 NN cord-013590-pkm81fq1 352 1 + + CC cord-013590-pkm81fq1 352 2 TCRs TCRs NNP cord-013590-pkm81fq1 352 3 23 23 CD cord-013590-pkm81fq1 352 4 , , , cord-013590-pkm81fq1 352 5 34 34 CD cord-013590-pkm81fq1 352 6 , , , cord-013590-pkm81fq1 352 7 129 129 CD cord-013590-pkm81fq1 352 8 and and CC cord-013590-pkm81fq1 352 9 in in IN cord-013590-pkm81fq1 352 10 CMV CMV NNP cord-013590-pkm81fq1 352 11 - - HYPH cord-013590-pkm81fq1 352 12 positive positive JJ cord-013590-pkm81fq1 352 13 bone bone NN cord-013590-pkm81fq1 352 14 marrow marrow NN cord-013590-pkm81fq1 352 15 grafts graft VBZ cord-013590-pkm81fq1 352 16 the the DT cord-013590-pkm81fq1 352 17 frequency frequency NN cord-013590-pkm81fq1 352 18 of of IN cord-013590-pkm81fq1 352 19 CD8 CD8 NNP cord-013590-pkm81fq1 352 20 + + SYM cord-013590-pkm81fq1 352 21 Vδ1 Vδ1 NNP cord-013590-pkm81fq1 353 1 + + CC cord-013590-pkm81fq1 353 2 γδ γδ IN cord-013590-pkm81fq1 353 3 T t NN cord-013590-pkm81fq1 353 4 cells cell NNS cord-013590-pkm81fq1 353 5 was be VBD cord-013590-pkm81fq1 353 6 increased increase VBN cord-013590-pkm81fq1 353 7 , , , cord-013590-pkm81fq1 353 8 indicative indicative JJ cord-013590-pkm81fq1 353 9 of of IN cord-013590-pkm81fq1 353 10 a a DT cord-013590-pkm81fq1 353 11 potential potential JJ cord-013590-pkm81fq1 353 12 costimulatory costimulatory NN cord-013590-pkm81fq1 353 13 role role NN cord-013590-pkm81fq1 353 14 of of IN cord-013590-pkm81fq1 353 15 CD8 CD8 NNP cord-013590-pkm81fq1 353 16 for for IN cord-013590-pkm81fq1 353 17 Vδ1 Vδ1 NNP cord-013590-pkm81fq1 353 18 + + SYM cord-013590-pkm81fq1 353 19 TCRs tcr NNS cord-013590-pkm81fq1 353 20 . . . cord-013590-pkm81fq1 354 1 130 130 CD cord-013590-pkm81fq1 355 1 The the DT cord-013590-pkm81fq1 355 2 exact exact JJ cord-013590-pkm81fq1 355 3 contribution contribution NN cord-013590-pkm81fq1 355 4 of of IN cord-013590-pkm81fq1 355 5 all all PDT cord-013590-pkm81fq1 355 6 these these DT cord-013590-pkm81fq1 355 7 proposed propose VBN cord-013590-pkm81fq1 355 8 co co JJ cord-013590-pkm81fq1 355 9 - - JJ cord-013590-pkm81fq1 355 10 stimulatory stimulatory JJ cord-013590-pkm81fq1 355 11 molecules molecule NNS cord-013590-pkm81fq1 355 12 to to IN cord-013590-pkm81fq1 355 13 γδ γδ NNP cord-013590-pkm81fq1 355 14 T t NN cord-013590-pkm81fq1 355 15 - - HYPH cord-013590-pkm81fq1 355 16 cell cell NN cord-013590-pkm81fq1 355 17 - - HYPH cord-013590-pkm81fq1 355 18 mediated mediate VBN cord-013590-pkm81fq1 355 19 immune immune JJ cord-013590-pkm81fq1 355 20 responses response NNS cord-013590-pkm81fq1 355 21 remains remain VBZ cord-013590-pkm81fq1 355 22 to to IN cord-013590-pkm81fq1 355 23 a a DT cord-013590-pkm81fq1 355 24 large large JJ cord-013590-pkm81fq1 355 25 extent extent NN cord-013590-pkm81fq1 355 26 unclear unclear JJ cord-013590-pkm81fq1 355 27 as as IN cord-013590-pkm81fq1 355 28 they -PRON- PRP cord-013590-pkm81fq1 355 29 are be VBP cord-013590-pkm81fq1 355 30 often often RB cord-013590-pkm81fq1 355 31 only only RB cord-013590-pkm81fq1 355 32 expressed express VBN cord-013590-pkm81fq1 355 33 by by IN cord-013590-pkm81fq1 355 34 certain certain JJ cord-013590-pkm81fq1 355 35 γδ γδ IN cord-013590-pkm81fq1 355 36 T t NN cord-013590-pkm81fq1 355 37 - - HYPH cord-013590-pkm81fq1 355 38 cell cell NN cord-013590-pkm81fq1 355 39 subsets subset NNS cord-013590-pkm81fq1 355 40 and and CC cord-013590-pkm81fq1 355 41 functional functional JJ cord-013590-pkm81fq1 355 42 in in IN cord-013590-pkm81fq1 355 43 vivo vivo NN cord-013590-pkm81fq1 355 44 studies study NNS cord-013590-pkm81fq1 355 45 are be VBP cord-013590-pkm81fq1 355 46 missing miss VBG cord-013590-pkm81fq1 355 47 . . . cord-013590-pkm81fq1 356 1 Even even RB cord-013590-pkm81fq1 356 2 more more RBR cord-013590-pkm81fq1 356 3 controversial controversial JJ cord-013590-pkm81fq1 356 4 is be VBZ cord-013590-pkm81fq1 356 5 the the DT cord-013590-pkm81fq1 356 6 role role NN cord-013590-pkm81fq1 356 7 of of IN cord-013590-pkm81fq1 356 8 the the DT cord-013590-pkm81fq1 356 9 Natural Natural NNP cord-013590-pkm81fq1 356 10 - - HYPH cord-013590-pkm81fq1 356 11 Killer Killer NNP cord-013590-pkm81fq1 356 12 group group NN cord-013590-pkm81fq1 356 13 2 2 CD cord-013590-pkm81fq1 356 14 , , , cord-013590-pkm81fq1 356 15 member member NN cord-013590-pkm81fq1 356 16 D D NNP cord-013590-pkm81fq1 356 17 ( ( -LRB- cord-013590-pkm81fq1 356 18 NKG2D nkg2d NN cord-013590-pkm81fq1 356 19 ) ) -RRB- cord-013590-pkm81fq1 356 20 receptor receptor NN cord-013590-pkm81fq1 356 21 that that WDT cord-013590-pkm81fq1 356 22 was be VBD cord-013590-pkm81fq1 356 23 reported report VBN cord-013590-pkm81fq1 356 24 to to TO cord-013590-pkm81fq1 356 25 enhance enhance VB cord-013590-pkm81fq1 356 26 TCRmediated tcrmediated JJ cord-013590-pkm81fq1 356 27 immune immune JJ cord-013590-pkm81fq1 356 28 responses response NNS cord-013590-pkm81fq1 356 29 of of IN cord-013590-pkm81fq1 356 30 γδ γδ NNP cord-013590-pkm81fq1 356 31 T T NNP cord-013590-pkm81fq1 356 32 cells cell NNS cord-013590-pkm81fq1 356 33 . . . cord-013590-pkm81fq1 357 1 55 55 CD cord-013590-pkm81fq1 357 2 , , , cord-013590-pkm81fq1 357 3 131 131 CD cord-013590-pkm81fq1 357 4 , , , cord-013590-pkm81fq1 357 5 132 132 CD cord-013590-pkm81fq1 357 6 Interestingly interestingly RB cord-013590-pkm81fq1 357 7 , , , cord-013590-pkm81fq1 357 8 NKG2D NKG2D NNS cord-013590-pkm81fq1 357 9 - - HYPH cord-013590-pkm81fq1 357 10 ligands ligand NNS cord-013590-pkm81fq1 357 11 MICA MICA NNP cord-013590-pkm81fq1 357 12 and and CC cord-013590-pkm81fq1 357 13 MICB MICB NNP cord-013590-pkm81fq1 357 14 are be VBP cord-013590-pkm81fq1 357 15 also also RB cord-013590-pkm81fq1 357 16 recognized recognize VBN cord-013590-pkm81fq1 357 17 by by IN cord-013590-pkm81fq1 357 18 Vδ1 vδ1 NN cord-013590-pkm81fq1 357 19 + + SYM cord-013590-pkm81fq1 358 1 TCRs TCRs NNP cord-013590-pkm81fq1 358 2 and and CC cord-013590-pkm81fq1 358 3 γδ γδ NNP cord-013590-pkm81fq1 358 4 T t NN cord-013590-pkm81fq1 358 5 cells cell NNS cord-013590-pkm81fq1 358 6 expressing express VBG cord-013590-pkm81fq1 358 7 both both DT cord-013590-pkm81fq1 358 8 receptors receptor NNS cord-013590-pkm81fq1 358 9 seem seem VBP cord-013590-pkm81fq1 358 10 to to TO cord-013590-pkm81fq1 358 11 require require VB cord-013590-pkm81fq1 358 12 signals signal NNS cord-013590-pkm81fq1 358 13 from from IN cord-013590-pkm81fq1 358 14 both both DT cord-013590-pkm81fq1 358 15 receptors receptor NNS cord-013590-pkm81fq1 358 16 to to TO cord-013590-pkm81fq1 358 17 get get VB cord-013590-pkm81fq1 358 18 activated activate VBN cord-013590-pkm81fq1 358 19 . . . cord-013590-pkm81fq1 359 1 45 45 CD cord-013590-pkm81fq1 360 1 Like like IN cord-013590-pkm81fq1 360 2 other other JJ cord-013590-pkm81fq1 360 3 NK nk NN cord-013590-pkm81fq1 360 4 - - HYPH cord-013590-pkm81fq1 360 5 receptors receptor NNS cord-013590-pkm81fq1 360 6 , , , cord-013590-pkm81fq1 360 7 NKG2D NKG2D NNS cord-013590-pkm81fq1 360 8 is be VBZ cord-013590-pkm81fq1 360 9 able able JJ cord-013590-pkm81fq1 360 10 to to TO cord-013590-pkm81fq1 360 11 activate activate VB cord-013590-pkm81fq1 360 12 γδ γδ IN cord-013590-pkm81fq1 360 13 T t NN cord-013590-pkm81fq1 360 14 cells cell NNS cord-013590-pkm81fq1 360 15 without without IN cord-013590-pkm81fq1 360 16 involving involve VBG cord-013590-pkm81fq1 360 17 the the DT cord-013590-pkm81fq1 360 18 γδ γδ NNP cord-013590-pkm81fq1 360 19 TCR TCR NNP cord-013590-pkm81fq1 360 20 . . . cord-013590-pkm81fq1 361 1 133 133 CD cord-013590-pkm81fq1 362 1 It -PRON- PRP cord-013590-pkm81fq1 362 2 is be VBZ cord-013590-pkm81fq1 362 3 thus thus RB cord-013590-pkm81fq1 362 4 difficult difficult JJ cord-013590-pkm81fq1 362 5 to to TO cord-013590-pkm81fq1 362 6 properly properly RB cord-013590-pkm81fq1 362 7 dissect dissect VB cord-013590-pkm81fq1 362 8 whether whether IN cord-013590-pkm81fq1 362 9 the the DT cord-013590-pkm81fq1 362 10 role role NN cord-013590-pkm81fq1 362 11 of of IN cord-013590-pkm81fq1 362 12 NKG2D nkg2d NN cord-013590-pkm81fq1 362 13 can can MD cord-013590-pkm81fq1 362 14 be be VB cord-013590-pkm81fq1 362 15 defined define VBN cord-013590-pkm81fq1 362 16 as as IN cord-013590-pkm81fq1 362 17 co co JJ cord-013590-pkm81fq1 362 18 - - JJ cord-013590-pkm81fq1 362 19 stimulatory stimulatory JJ cord-013590-pkm81fq1 362 20 or or CC cord-013590-pkm81fq1 362 21 whether whether IN cord-013590-pkm81fq1 362 22 γδ γδ NNP cord-013590-pkm81fq1 362 23 TCR TCR NNP cord-013590-pkm81fq1 362 24 and and CC cord-013590-pkm81fq1 362 25 NKG2D NKG2D NNP cord-013590-pkm81fq1 362 26 act act NNP cord-013590-pkm81fq1 362 27 sequentially sequentially RB cord-013590-pkm81fq1 362 28 as as RB cord-013590-pkm81fq1 362 29 suggested suggest VBN cord-013590-pkm81fq1 362 30 by by IN cord-013590-pkm81fq1 362 31 Ribot Ribot NNP cord-013590-pkm81fq1 362 32 et et NNP cord-013590-pkm81fq1 362 33 al al NNP cord-013590-pkm81fq1 362 34 . . . cord-013590-pkm81fq1 362 35 122 122 CD cord-013590-pkm81fq1 363 1 Besides besides IN cord-013590-pkm81fq1 363 2 differential differential JJ cord-013590-pkm81fq1 363 3 expression expression NN cord-013590-pkm81fq1 363 4 and and CC cord-013590-pkm81fq1 363 5 co co NN cord-013590-pkm81fq1 363 6 - - NN cord-013590-pkm81fq1 363 7 stimulation stimulation NN cord-013590-pkm81fq1 363 8 by by IN cord-013590-pkm81fq1 363 9 other other JJ cord-013590-pkm81fq1 363 10 surface surface NN cord-013590-pkm81fq1 363 11 molecules molecule NNS cord-013590-pkm81fq1 363 12 , , , cord-013590-pkm81fq1 363 13 intramolecular intramolecular JJ cord-013590-pkm81fq1 363 14 mechanisms mechanism NNS cord-013590-pkm81fq1 363 15 might may MD cord-013590-pkm81fq1 363 16 be be VB cord-013590-pkm81fq1 363 17 involved involve VBN cord-013590-pkm81fq1 363 18 in in IN cord-013590-pkm81fq1 363 19 the the DT cord-013590-pkm81fq1 363 20 regulation regulation NN cord-013590-pkm81fq1 363 21 of of IN cord-013590-pkm81fq1 363 22 γδ γδ NN cord-013590-pkm81fq1 364 1 TCR TCR NNP cord-013590-pkm81fq1 364 2 enabling enable VBG cord-013590-pkm81fq1 364 3 the the DT cord-013590-pkm81fq1 364 4 distinction distinction NN cord-013590-pkm81fq1 364 5 of of IN cord-013590-pkm81fq1 364 6 homeostatic homeostatic JJ cord-013590-pkm81fq1 364 7 and and CC cord-013590-pkm81fq1 364 8 stress stress NN cord-013590-pkm81fq1 364 9 conditions condition NNS cord-013590-pkm81fq1 364 10 . . . cord-013590-pkm81fq1 365 1 These these DT cord-013590-pkm81fq1 365 2 include include VBP cord-013590-pkm81fq1 365 3 e.g. e.g. RB cord-013590-pkm81fq1 365 4 , , , cord-013590-pkm81fq1 365 5 conformational conformational JJ cord-013590-pkm81fq1 365 6 changes change NNS cord-013590-pkm81fq1 365 7 that that WDT cord-013590-pkm81fq1 365 8 increase increase VBP cord-013590-pkm81fq1 365 9 the the DT cord-013590-pkm81fq1 365 10 accessibility accessibility NN cord-013590-pkm81fq1 365 11 of of IN cord-013590-pkm81fq1 365 12 domains domain NNS cord-013590-pkm81fq1 365 13 required require VBN cord-013590-pkm81fq1 365 14 for for IN cord-013590-pkm81fq1 365 15 proper proper JJ cord-013590-pkm81fq1 365 16 γδ γδ NN cord-013590-pkm81fq1 365 17 TCR TCR NNP cord-013590-pkm81fq1 365 18 activation activation NN cord-013590-pkm81fq1 365 19 ( ( -LRB- cord-013590-pkm81fq1 365 20 Fig Fig NNP cord-013590-pkm81fq1 365 21 . . . cord-013590-pkm81fq1 365 22 1c 1c NNP cord-013590-pkm81fq1 365 23 ) ) -RRB- cord-013590-pkm81fq1 365 24 or or CC cord-013590-pkm81fq1 365 25 post post JJ cord-013590-pkm81fq1 365 26 - - JJ cord-013590-pkm81fq1 365 27 translational translational JJ cord-013590-pkm81fq1 365 28 modifications modification NNS cord-013590-pkm81fq1 365 29 such such JJ cord-013590-pkm81fq1 365 30 as as IN cord-013590-pkm81fq1 365 31 glycosylation glycosylation NN cord-013590-pkm81fq1 365 32 ( ( -LRB- cord-013590-pkm81fq1 365 33 Fig fig NN cord-013590-pkm81fq1 365 34 . . . cord-013590-pkm81fq1 365 35 1e 1e LS cord-013590-pkm81fq1 365 36 ) ) -RRB- cord-013590-pkm81fq1 365 37 . . . cord-013590-pkm81fq1 366 1 The the DT cord-013590-pkm81fq1 366 2 p p NN cord-013590-pkm81fq1 366 3 - - HYPH cord-013590-pkm81fq1 366 4 Ag Ag NNP cord-013590-pkm81fq1 366 5 - - HYPH cord-013590-pkm81fq1 366 6 mediated mediate VBN cord-013590-pkm81fq1 366 7 conformational conformational JJ cord-013590-pkm81fq1 366 8 changes change NNS cord-013590-pkm81fq1 366 9 in in IN cord-013590-pkm81fq1 366 10 BTN3A1 BTN3A1 NNP cord-013590-pkm81fq1 366 11 mentioned mention VBN cord-013590-pkm81fq1 366 12 previously previously RB cord-013590-pkm81fq1 366 13 are be VBP cord-013590-pkm81fq1 366 14 an an DT cord-013590-pkm81fq1 366 15 example example NN cord-013590-pkm81fq1 366 16 for for IN cord-013590-pkm81fq1 366 17 this this DT cord-013590-pkm81fq1 366 18 . . . cord-013590-pkm81fq1 367 1 97 97 CD cord-013590-pkm81fq1 367 2 , , , cord-013590-pkm81fq1 367 3 100 100 CD cord-013590-pkm81fq1 368 1 Although although IN cord-013590-pkm81fq1 368 2 no no DT cord-013590-pkm81fq1 368 3 direct direct JJ cord-013590-pkm81fq1 368 4 binding binding NN cord-013590-pkm81fq1 368 5 of of IN cord-013590-pkm81fq1 368 6 the the DT cord-013590-pkm81fq1 368 7 Vγ9Vδ2 Vγ9Vδ2 NNS cord-013590-pkm81fq1 368 8 + + CC cord-013590-pkm81fq1 368 9 TCR TCR NNP cord-013590-pkm81fq1 368 10 to to IN cord-013590-pkm81fq1 368 11 BTN3A1 BTN3A1 NNP cord-013590-pkm81fq1 368 12 has have VBZ cord-013590-pkm81fq1 368 13 been be VBN cord-013590-pkm81fq1 368 14 observed observe VBN cord-013590-pkm81fq1 368 15 so so RB cord-013590-pkm81fq1 368 16 far far RB cord-013590-pkm81fq1 368 17 , , , cord-013590-pkm81fq1 368 18 this this DT cord-013590-pkm81fq1 368 19 conformational conformational JJ cord-013590-pkm81fq1 368 20 change change NN cord-013590-pkm81fq1 368 21 is be VBZ cord-013590-pkm81fq1 368 22 required require VBN cord-013590-pkm81fq1 368 23 for for IN cord-013590-pkm81fq1 368 24 p p NN cord-013590-pkm81fq1 368 25 - - : cord-013590-pkm81fq1 368 26 Ag Ag NNP cord-013590-pkm81fq1 368 27 - - HYPH cord-013590-pkm81fq1 368 28 mediated mediate VBN cord-013590-pkm81fq1 368 29 activation activation NN cord-013590-pkm81fq1 368 30 either either CC cord-013590-pkm81fq1 368 31 via via IN cord-013590-pkm81fq1 368 32 BTN3A1 BTN3A1 NNP cord-013590-pkm81fq1 368 33 interacting interact VBG cord-013590-pkm81fq1 368 34 with with IN cord-013590-pkm81fq1 368 35 the the DT cord-013590-pkm81fq1 368 36 CDRs cdr NNS cord-013590-pkm81fq1 368 37 of of IN cord-013590-pkm81fq1 368 38 the the DT cord-013590-pkm81fq1 368 39 TCR TCR NNP cord-013590-pkm81fq1 368 40 or or CC cord-013590-pkm81fq1 368 41 indirectly indirectly RB cord-013590-pkm81fq1 368 42 via via IN cord-013590-pkm81fq1 368 43 a a DT cord-013590-pkm81fq1 368 44 yet yet RB cord-013590-pkm81fq1 368 45 unknown unknown JJ cord-013590-pkm81fq1 368 46 molecule molecule NN cord-013590-pkm81fq1 368 47 . . . cord-013590-pkm81fq1 369 1 Conformational Conformational NNP cord-013590-pkm81fq1 369 2 differences difference NNS cord-013590-pkm81fq1 369 3 of of IN cord-013590-pkm81fq1 369 4 γδ γδ XX cord-013590-pkm81fq1 370 1 TCR TCR NNP cord-013590-pkm81fq1 370 2 ligands ligand NNS cord-013590-pkm81fq1 370 3 might may MD cord-013590-pkm81fq1 370 4 also also RB cord-013590-pkm81fq1 370 5 be be VB cord-013590-pkm81fq1 370 6 caused cause VBN cord-013590-pkm81fq1 370 7 by by IN cord-013590-pkm81fq1 370 8 multimerization multimerization NN cord-013590-pkm81fq1 370 9 as as IN cord-013590-pkm81fq1 370 10 it -PRON- PRP cord-013590-pkm81fq1 370 11 is be VBZ cord-013590-pkm81fq1 370 12 the the DT cord-013590-pkm81fq1 370 13 case case NN cord-013590-pkm81fq1 370 14 for for IN cord-013590-pkm81fq1 370 15 the the DT cord-013590-pkm81fq1 370 16 MHCmolecule MHCmolecule NNP cord-013590-pkm81fq1 370 17 HLA HLA NNP cord-013590-pkm81fq1 370 18 * * NFP cord-013590-pkm81fq1 370 19 24:02 24:02 CD cord-013590-pkm81fq1 370 20 recognized recognize VBN cord-013590-pkm81fq1 370 21 by by IN cord-013590-pkm81fq1 370 22 the the DT cord-013590-pkm81fq1 370 23 alloreactive alloreactive NN cord-013590-pkm81fq1 370 24 Vγ5Vδ1 Vγ5Vδ1 . cord-013590-pkm81fq1 371 1 + + CC cord-013590-pkm81fq1 371 2 TCR TCR NNP cord-013590-pkm81fq1 371 3 23 23 CD cord-013590-pkm81fq1 372 1 ( ( -LRB- cord-013590-pkm81fq1 372 2 Fig Fig NNP cord-013590-pkm81fq1 372 3 . . . cord-013590-pkm81fq1 372 4 1d 1d CD cord-013590-pkm81fq1 372 5 ) ) -RRB- cord-013590-pkm81fq1 372 6 . . . cord-013590-pkm81fq1 373 1 Being be VBG cord-013590-pkm81fq1 373 2 present present JJ cord-013590-pkm81fq1 373 3 as as IN cord-013590-pkm81fq1 373 4 homodimers homodimer NNS cord-013590-pkm81fq1 373 5 under under IN cord-013590-pkm81fq1 373 6 regular regular JJ cord-013590-pkm81fq1 373 7 conditions condition NNS cord-013590-pkm81fq1 373 8 , , , cord-013590-pkm81fq1 373 9 malignant malignant JJ cord-013590-pkm81fq1 373 10 transformation transformation NN cord-013590-pkm81fq1 373 11 seems seem VBZ cord-013590-pkm81fq1 373 12 to to TO cord-013590-pkm81fq1 373 13 induce induce VB cord-013590-pkm81fq1 373 14 changes change NNS cord-013590-pkm81fq1 373 15 in in IN cord-013590-pkm81fq1 373 16 the the DT cord-013590-pkm81fq1 373 17 spatial spatial JJ cord-013590-pkm81fq1 373 18 organization organization NN cord-013590-pkm81fq1 373 19 of of IN cord-013590-pkm81fq1 373 20 HLA HLA NNP cord-013590-pkm81fq1 373 21 * * NFP cord-013590-pkm81fq1 373 22 24:02 24:02 CD cord-013590-pkm81fq1 373 23 at at IN cord-013590-pkm81fq1 373 24 the the DT cord-013590-pkm81fq1 373 25 cell cell NN cord-013590-pkm81fq1 373 26 surface surface NN cord-013590-pkm81fq1 373 27 so so IN cord-013590-pkm81fq1 373 28 that that IN cord-013590-pkm81fq1 373 29 it -PRON- PRP cord-013590-pkm81fq1 373 30 occurs occur VBZ cord-013590-pkm81fq1 373 31 as as IN cord-013590-pkm81fq1 373 32 monomers monomer NNS cord-013590-pkm81fq1 373 33 . . . cord-013590-pkm81fq1 374 1 This this DT cord-013590-pkm81fq1 374 2 restructuring restructuring NN cord-013590-pkm81fq1 374 3 is be VBZ cord-013590-pkm81fq1 374 4 essential essential JJ cord-013590-pkm81fq1 374 5 for for IN cord-013590-pkm81fq1 374 6 γδ γδ XX cord-013590-pkm81fq1 375 1 TCR TCR NNP cord-013590-pkm81fq1 375 2 recognition recognition NN cord-013590-pkm81fq1 375 3 as as IN cord-013590-pkm81fq1 375 4 fixation fixation NN cord-013590-pkm81fq1 375 5 of of IN cord-013590-pkm81fq1 375 6 the the DT cord-013590-pkm81fq1 375 7 dimeric dimeric JJ cord-013590-pkm81fq1 375 8 form form NN cord-013590-pkm81fq1 375 9 of of IN cord-013590-pkm81fq1 375 10 HLA HLA NNP cord-013590-pkm81fq1 375 11 * * NFP cord-013590-pkm81fq1 375 12 24:02 24:02 CD cord-013590-pkm81fq1 375 13 led lead VBD cord-013590-pkm81fq1 375 14 to to IN cord-013590-pkm81fq1 375 15 the the DT cord-013590-pkm81fq1 375 16 abrogation abrogation NN cord-013590-pkm81fq1 375 17 of of IN cord-013590-pkm81fq1 375 18 TCR TCR NNP cord-013590-pkm81fq1 375 19 - - HYPH cord-013590-pkm81fq1 375 20 mediated mediate VBN cord-013590-pkm81fq1 375 21 activation activation NN cord-013590-pkm81fq1 375 22 . . . cord-013590-pkm81fq1 376 1 The the DT cord-013590-pkm81fq1 376 2 influence influence NN cord-013590-pkm81fq1 376 3 of of IN cord-013590-pkm81fq1 376 4 antigen antigen NN cord-013590-pkm81fq1 376 5 glycosylation glycosylation NN cord-013590-pkm81fq1 376 6 on on IN cord-013590-pkm81fq1 376 7 γδ γδ XX cord-013590-pkm81fq1 377 1 TCR TCR NNP cord-013590-pkm81fq1 377 2 activation activation NN cord-013590-pkm81fq1 377 3 has have VBZ cord-013590-pkm81fq1 377 4 so so RB cord-013590-pkm81fq1 377 5 far far RB cord-013590-pkm81fq1 377 6 not not RB cord-013590-pkm81fq1 377 7 been be VBN cord-013590-pkm81fq1 377 8 investigated investigate VBN cord-013590-pkm81fq1 377 9 in in IN cord-013590-pkm81fq1 377 10 detail detail NN cord-013590-pkm81fq1 377 11 but but CC cord-013590-pkm81fq1 377 12 some some DT cord-013590-pkm81fq1 377 13 publications publication NNS cord-013590-pkm81fq1 377 14 suggest suggest VBP cord-013590-pkm81fq1 377 15 that that IN cord-013590-pkm81fq1 377 16 they -PRON- PRP cord-013590-pkm81fq1 377 17 are be VBP cord-013590-pkm81fq1 377 18 relevant relevant JJ cord-013590-pkm81fq1 377 19 for for IN cord-013590-pkm81fq1 377 20 ligand ligand NN cord-013590-pkm81fq1 377 21 recognition recognition NN cord-013590-pkm81fq1 377 22 . . . cord-013590-pkm81fq1 378 1 In in IN cord-013590-pkm81fq1 378 2 fact fact NN cord-013590-pkm81fq1 378 3 , , , cord-013590-pkm81fq1 378 4 changes change NNS cord-013590-pkm81fq1 378 5 in in IN cord-013590-pkm81fq1 378 6 surface surface NN cord-013590-pkm81fq1 378 7 glycosylation glycosylation NN cord-013590-pkm81fq1 378 8 patterns pattern NNS cord-013590-pkm81fq1 378 9 are be VBP cord-013590-pkm81fq1 378 10 known know VBN cord-013590-pkm81fq1 378 11 to to TO cord-013590-pkm81fq1 378 12 occur occur VB cord-013590-pkm81fq1 378 13 in in IN cord-013590-pkm81fq1 378 14 infected infect VBN cord-013590-pkm81fq1 378 15 or or CC cord-013590-pkm81fq1 378 16 transformed transform VBN cord-013590-pkm81fq1 378 17 cells cell NNS cord-013590-pkm81fq1 378 18 . . . cord-013590-pkm81fq1 379 1 134 134 CD cord-013590-pkm81fq1 379 2 , , , cord-013590-pkm81fq1 379 3 135 135 CD cord-013590-pkm81fq1 379 4 It -PRON- PRP cord-013590-pkm81fq1 379 5 is be VBZ cord-013590-pkm81fq1 379 6 thus thus RB cord-013590-pkm81fq1 379 7 conceivable conceivable JJ cord-013590-pkm81fq1 379 8 that that IN cord-013590-pkm81fq1 379 9 immune immune JJ cord-013590-pkm81fq1 379 10 receptors receptor NNS cord-013590-pkm81fq1 379 11 recognizing recognize VBG cord-013590-pkm81fq1 379 12 mostly mostly RB cord-013590-pkm81fq1 379 13 glycosylated glycosylated JJ cord-013590-pkm81fq1 379 14 cell cell NN cord-013590-pkm81fq1 379 15 - - HYPH cord-013590-pkm81fq1 379 16 surface surface NN cord-013590-pkm81fq1 379 17 molecules molecule NNS cord-013590-pkm81fq1 379 18 like like IN cord-013590-pkm81fq1 379 19 γδ γδ IN cord-013590-pkm81fq1 379 20 TCRs tcr NNS cord-013590-pkm81fq1 379 21 are be VBP cord-013590-pkm81fq1 379 22 to to IN cord-013590-pkm81fq1 379 23 some some DT cord-013590-pkm81fq1 379 24 extent extent NN cord-013590-pkm81fq1 379 25 reacting react VBG cord-013590-pkm81fq1 379 26 to to IN cord-013590-pkm81fq1 379 27 these these DT cord-013590-pkm81fq1 379 28 changes change NNS cord-013590-pkm81fq1 379 29 ( ( -LRB- cord-013590-pkm81fq1 379 30 Fig Fig NNP cord-013590-pkm81fq1 379 31 . . . cord-013590-pkm81fq1 379 32 1e 1e LS cord-013590-pkm81fq1 379 33 ) ) -RRB- cord-013590-pkm81fq1 379 34 . . . cord-013590-pkm81fq1 380 1 As as IN cord-013590-pkm81fq1 380 2 the the DT cord-013590-pkm81fq1 380 3 investigation investigation NN cord-013590-pkm81fq1 380 4 of of IN cord-013590-pkm81fq1 380 5 carbohydrates carbohydrate NNS cord-013590-pkm81fq1 380 6 and and CC cord-013590-pkm81fq1 380 7 their -PRON- PRP$ cord-013590-pkm81fq1 380 8 effects effect NNS cord-013590-pkm81fq1 380 9 is be VBZ cord-013590-pkm81fq1 380 10 difficult difficult JJ cord-013590-pkm81fq1 380 11 with with IN cord-013590-pkm81fq1 380 12 conventional conventional JJ cord-013590-pkm81fq1 380 13 molecular molecular JJ cord-013590-pkm81fq1 380 14 biology biology NN cord-013590-pkm81fq1 380 15 techniques technique NNS cord-013590-pkm81fq1 380 16 , , , cord-013590-pkm81fq1 380 17 data datum NNS cord-013590-pkm81fq1 380 18 on on IN cord-013590-pkm81fq1 380 19 the the DT cord-013590-pkm81fq1 380 20 influence influence NN cord-013590-pkm81fq1 380 21 of of IN cord-013590-pkm81fq1 380 22 glycosylation glycosylation NN cord-013590-pkm81fq1 380 23 on on IN cord-013590-pkm81fq1 380 24 γδ γδ XX cord-013590-pkm81fq1 381 1 TCR TCR NNP cord-013590-pkm81fq1 381 2 binding binding NN cord-013590-pkm81fq1 381 3 and and CC cord-013590-pkm81fq1 381 4 activation activation NN cord-013590-pkm81fq1 381 5 is be VBZ cord-013590-pkm81fq1 381 6 still still RB cord-013590-pkm81fq1 381 7 quite quite RB cord-013590-pkm81fq1 381 8 sparse sparse JJ cord-013590-pkm81fq1 381 9 . . . cord-013590-pkm81fq1 382 1 For for IN cord-013590-pkm81fq1 382 2 example example NN cord-013590-pkm81fq1 382 3 , , , cord-013590-pkm81fq1 382 4 the the DT cord-013590-pkm81fq1 382 5 recognition recognition NN cord-013590-pkm81fq1 382 6 of of IN cord-013590-pkm81fq1 382 7 HLA HLA NNP cord-013590-pkm81fq1 382 8 I I NNP cord-013590-pkm81fq1 382 9 - - HYPH cord-013590-pkm81fq1 382 10 E E NNP cord-013590-pkm81fq1 382 11 by by IN cord-013590-pkm81fq1 382 12 the the DT cord-013590-pkm81fq1 382 13 murine murine NN cord-013590-pkm81fq1 382 14 γδ γδ IN cord-013590-pkm81fq1 382 15 TCR TCR NNP cord-013590-pkm81fq1 382 16 LBK5 LBK5 NNP cord-013590-pkm81fq1 382 17 is be VBZ cord-013590-pkm81fq1 382 18 influenced influence VBN cord-013590-pkm81fq1 382 19 by by IN cord-013590-pkm81fq1 382 20 changes change NNS cord-013590-pkm81fq1 382 21 in in IN cord-013590-pkm81fq1 382 22 the the DT cord-013590-pkm81fq1 382 23 Nglycosylation Nglycosylation NNP cord-013590-pkm81fq1 382 24 at at IN cord-013590-pkm81fq1 382 25 position position NN cord-013590-pkm81fq1 382 26 82 82 CD cord-013590-pkm81fq1 382 27 of of IN cord-013590-pkm81fq1 382 28 its -PRON- PRP$ cord-013590-pkm81fq1 382 29 α α NN cord-013590-pkm81fq1 382 30 - - HYPH cord-013590-pkm81fq1 382 31 chain chain NN cord-013590-pkm81fq1 382 32 . . . cord-013590-pkm81fq1 383 1 119 119 CD cord-013590-pkm81fq1 384 1 Furthermore furthermore RB cord-013590-pkm81fq1 384 2 , , , cord-013590-pkm81fq1 384 3 recognition recognition NN cord-013590-pkm81fq1 384 4 of of IN cord-013590-pkm81fq1 384 5 glycosphingolipids glycosphingolipid NNS cord-013590-pkm81fq1 384 6 by by IN cord-013590-pkm81fq1 384 7 a a DT cord-013590-pkm81fq1 384 8 subset subset NN cord-013590-pkm81fq1 384 9 of of IN cord-013590-pkm81fq1 384 10 murine murine NN cord-013590-pkm81fq1 384 11 γδ γδ IN cord-013590-pkm81fq1 384 12 T t NN cord-013590-pkm81fq1 384 13 cells cell NNS cord-013590-pkm81fq1 384 14 has have VBZ cord-013590-pkm81fq1 384 15 been be VBN cord-013590-pkm81fq1 384 16 reported report VBN cord-013590-pkm81fq1 384 17 to to TO cord-013590-pkm81fq1 384 18 be be VB cord-013590-pkm81fq1 384 19 dependent dependent JJ cord-013590-pkm81fq1 384 20 on on IN cord-013590-pkm81fq1 384 21 specific specific JJ cord-013590-pkm81fq1 384 22 carbohydrate carbohydrate NN cord-013590-pkm81fq1 384 23 residues residue NNS cord-013590-pkm81fq1 384 24 but but CC cord-013590-pkm81fq1 384 25 to to IN cord-013590-pkm81fq1 384 26 what what WDT cord-013590-pkm81fq1 384 27 extent extent NN cord-013590-pkm81fq1 384 28 the the DT cord-013590-pkm81fq1 384 29 γδ γδ NN cord-013590-pkm81fq1 385 1 TCR TCR NNP cord-013590-pkm81fq1 385 2 is be VBZ cord-013590-pkm81fq1 385 3 involved involve VBN cord-013590-pkm81fq1 385 4 in in IN cord-013590-pkm81fq1 385 5 this this DT cord-013590-pkm81fq1 385 6 process process NN cord-013590-pkm81fq1 385 7 has have VBZ cord-013590-pkm81fq1 385 8 not not RB cord-013590-pkm81fq1 385 9 unambiguously unambiguously RB cord-013590-pkm81fq1 385 10 been be VBN cord-013590-pkm81fq1 385 11 shown show VBN cord-013590-pkm81fq1 385 12 . . . cord-013590-pkm81fq1 386 1 136 136 CD cord-013590-pkm81fq1 386 2 , , , cord-013590-pkm81fq1 387 1 137 137 CD cord-013590-pkm81fq1 387 2 More more RBR cord-013590-pkm81fq1 387 3 recently recently RB cord-013590-pkm81fq1 387 4 , , , cord-013590-pkm81fq1 387 5 a a DT cord-013590-pkm81fq1 387 6 study study NN cord-013590-pkm81fq1 387 7 with with IN cord-013590-pkm81fq1 387 8 soluble soluble JJ cord-013590-pkm81fq1 387 9 γδ γδ IN cord-013590-pkm81fq1 387 10 TCRs tcr NNS cord-013590-pkm81fq1 387 11 from from IN cord-013590-pkm81fq1 387 12 a a DT cord-013590-pkm81fq1 387 13 patient patient NN cord-013590-pkm81fq1 387 14 with with IN cord-013590-pkm81fq1 387 15 Lyme Lyme NNP cord-013590-pkm81fq1 387 16 arthritis arthritis NN cord-013590-pkm81fq1 387 17 revealed reveal VBD cord-013590-pkm81fq1 387 18 that that IN cord-013590-pkm81fq1 387 19 binding binding NN cord-013590-pkm81fq1 387 20 of of IN cord-013590-pkm81fq1 387 21 the the DT cord-013590-pkm81fq1 387 22 investigated investigate VBN cord-013590-pkm81fq1 387 23 receptors receptor NNS cord-013590-pkm81fq1 387 24 is be VBZ cord-013590-pkm81fq1 387 25 sensitive sensitive JJ cord-013590-pkm81fq1 387 26 to to IN cord-013590-pkm81fq1 387 27 cell cell NN cord-013590-pkm81fq1 387 28 - - HYPH cord-013590-pkm81fq1 387 29 surface surface NN cord-013590-pkm81fq1 387 30 digestion digestion NN cord-013590-pkm81fq1 387 31 of of IN cord-013590-pkm81fq1 387 32 glycans glycan NNS cord-013590-pkm81fq1 387 33 . . . cord-013590-pkm81fq1 388 1 138 138 CD cord-013590-pkm81fq1 389 1 Although although IN cord-013590-pkm81fq1 389 2 the the DT cord-013590-pkm81fq1 389 3 actual actual JJ cord-013590-pkm81fq1 389 4 ligand ligand NN cord-013590-pkm81fq1 389 5 for for IN cord-013590-pkm81fq1 389 6 the the DT cord-013590-pkm81fq1 389 7 respective respective JJ cord-013590-pkm81fq1 389 8 γδ γδ XX cord-013590-pkm81fq1 390 1 TCR TCR NNP cord-013590-pkm81fq1 390 2 was be VBD cord-013590-pkm81fq1 390 3 not not RB cord-013590-pkm81fq1 390 4 identified identify VBN cord-013590-pkm81fq1 390 5 , , , cord-013590-pkm81fq1 390 6 this this DT cord-013590-pkm81fq1 390 7 hints hint VBZ cord-013590-pkm81fq1 390 8 to to IN cord-013590-pkm81fq1 390 9 an an DT cord-013590-pkm81fq1 390 10 essential essential JJ cord-013590-pkm81fq1 390 11 role role NN cord-013590-pkm81fq1 390 12 of of IN cord-013590-pkm81fq1 390 13 carbohydrates carbohydrate NNS cord-013590-pkm81fq1 390 14 in in IN cord-013590-pkm81fq1 390 15 the the DT cord-013590-pkm81fq1 390 16 binding binding NN cord-013590-pkm81fq1 390 17 mechanism mechanism NN cord-013590-pkm81fq1 390 18 to to IN cord-013590-pkm81fq1 390 19 the the DT cord-013590-pkm81fq1 390 20 target target NN cord-013590-pkm81fq1 390 21 cells cell NNS cord-013590-pkm81fq1 390 22 . . . cord-013590-pkm81fq1 391 1 Whether whether IN cord-013590-pkm81fq1 391 2 the the DT cord-013590-pkm81fq1 391 3 γδ γδ XX cord-013590-pkm81fq1 391 4 TCRs tcr NNS cord-013590-pkm81fq1 391 5 in in IN cord-013590-pkm81fq1 391 6 all all PDT cord-013590-pkm81fq1 391 7 these these DT cord-013590-pkm81fq1 391 8 studies study NNS cord-013590-pkm81fq1 391 9 directly directly RB cord-013590-pkm81fq1 391 10 interacts interact VBZ cord-013590-pkm81fq1 391 11 with with IN cord-013590-pkm81fq1 391 12 the the DT cord-013590-pkm81fq1 391 13 respective respective JJ cord-013590-pkm81fq1 391 14 carbohydrates carbohydrate NNS cord-013590-pkm81fq1 391 15 and and CC cord-013590-pkm81fq1 391 16 whether whether IN cord-013590-pkm81fq1 391 17 the the DT cord-013590-pkm81fq1 391 18 influence influence NN cord-013590-pkm81fq1 391 19 thereof thereof RB cord-013590-pkm81fq1 391 20 can can MD cord-013590-pkm81fq1 391 21 be be VB cord-013590-pkm81fq1 391 22 generalized generalize VBN cord-013590-pkm81fq1 391 23 to to IN cord-013590-pkm81fq1 391 24 other other JJ cord-013590-pkm81fq1 391 25 γδ γδ IN cord-013590-pkm81fq1 391 26 TCRs tcr NNS cord-013590-pkm81fq1 391 27 requires require VBZ cord-013590-pkm81fq1 391 28 further further JJ cord-013590-pkm81fq1 391 29 investigation investigation NN cord-013590-pkm81fq1 391 30 . . . cord-013590-pkm81fq1 392 1 Finally finally RB cord-013590-pkm81fq1 392 2 , , , cord-013590-pkm81fq1 392 3 recent recent JJ cord-013590-pkm81fq1 392 4 data datum NNS cord-013590-pkm81fq1 392 5 on on IN cord-013590-pkm81fq1 392 6 MR-1-reactive mr-1-reactive CD cord-013590-pkm81fq1 392 7 γδ γδ IN cord-013590-pkm81fq1 392 8 TCRs tcr NNS cord-013590-pkm81fq1 392 9 suggest suggest VBP cord-013590-pkm81fq1 392 10 that that IN cord-013590-pkm81fq1 392 11 also also RB cord-013590-pkm81fq1 392 12 the the DT cord-013590-pkm81fq1 392 13 binding binding NN cord-013590-pkm81fq1 392 14 mode mode NN cord-013590-pkm81fq1 392 15 of of IN cord-013590-pkm81fq1 392 16 the the DT cord-013590-pkm81fq1 392 17 γδ γδ NN cord-013590-pkm81fq1 392 18 TCR TCR NNP cord-013590-pkm81fq1 392 19 to to IN cord-013590-pkm81fq1 392 20 its -PRON- PRP$ cord-013590-pkm81fq1 392 21 cognate cognate JJ cord-013590-pkm81fq1 392 22 antigen antigen NN cord-013590-pkm81fq1 392 23 could could MD cord-013590-pkm81fq1 392 24 be be VB cord-013590-pkm81fq1 392 25 of of IN cord-013590-pkm81fq1 392 26 relevance relevance NN cord-013590-pkm81fq1 392 27 for for IN cord-013590-pkm81fq1 392 28 the the DT cord-013590-pkm81fq1 392 29 degree degree NN cord-013590-pkm81fq1 392 30 of of IN cord-013590-pkm81fq1 392 31 activation activation NN cord-013590-pkm81fq1 392 32 induced induce VBN cord-013590-pkm81fq1 392 33 by by IN cord-013590-pkm81fq1 392 34 this this DT cord-013590-pkm81fq1 392 35 interaction interaction NN cord-013590-pkm81fq1 392 36 . . . cord-013590-pkm81fq1 393 1 43 43 CD cord-013590-pkm81fq1 394 1 Some some DT cord-013590-pkm81fq1 394 2 of of IN cord-013590-pkm81fq1 394 3 the the DT cord-013590-pkm81fq1 394 4 investigated investigate VBN cord-013590-pkm81fq1 394 5 human human JJ cord-013590-pkm81fq1 394 6 Vδ1 Vδ1 NNP cord-013590-pkm81fq1 394 7 + + SYM cord-013590-pkm81fq1 394 8 TCRs tcr NNS cord-013590-pkm81fq1 394 9 were be VBD cord-013590-pkm81fq1 394 10 interacting interact VBG cord-013590-pkm81fq1 394 11 with with IN cord-013590-pkm81fq1 394 12 the the DT cord-013590-pkm81fq1 394 13 α3-domain α3-domain NN cord-013590-pkm81fq1 394 14 on on IN cord-013590-pkm81fq1 394 15 the the DT cord-013590-pkm81fq1 394 16 side side NN cord-013590-pkm81fq1 394 17 of of IN cord-013590-pkm81fq1 394 18 MR-1 MR-1 NNP cord-013590-pkm81fq1 394 19 while while IN cord-013590-pkm81fq1 394 20 others other NNS cord-013590-pkm81fq1 394 21 were be VBD cord-013590-pkm81fq1 394 22 binding bind VBG cord-013590-pkm81fq1 394 23 from from IN cord-013590-pkm81fq1 394 24 the the DT cord-013590-pkm81fq1 394 25 top top NN cord-013590-pkm81fq1 394 26 to to IN cord-013590-pkm81fq1 394 27 the the DT cord-013590-pkm81fq1 394 28 actual actual JJ cord-013590-pkm81fq1 394 29 antigen antigen NN cord-013590-pkm81fq1 394 30 - - HYPH cord-013590-pkm81fq1 394 31 presenting present VBG cord-013590-pkm81fq1 394 32 cleft cleft NN cord-013590-pkm81fq1 394 33 of of IN cord-013590-pkm81fq1 394 34 MR-1 MR-1 NNP cord-013590-pkm81fq1 394 35 . . . cord-013590-pkm81fq1 395 1 The the DT cord-013590-pkm81fq1 395 2 γδ γδ IN cord-013590-pkm81fq1 395 3 TCRs tcr NNS cord-013590-pkm81fq1 395 4 also also RB cord-013590-pkm81fq1 395 5 differed differ VBD cord-013590-pkm81fq1 395 6 in in IN cord-013590-pkm81fq1 395 7 their -PRON- PRP$ cord-013590-pkm81fq1 395 8 capacity capacity NN cord-013590-pkm81fq1 395 9 to to TO cord-013590-pkm81fq1 395 10 induce induce VB cord-013590-pkm81fq1 395 11 intracellular intracellular JJ cord-013590-pkm81fq1 395 12 signal signal NN cord-013590-pkm81fq1 395 13 transduction transduction NN cord-013590-pkm81fq1 395 14 . . . cord-013590-pkm81fq1 396 1 Binding bind VBG cord-013590-pkm81fq1 396 2 to to IN cord-013590-pkm81fq1 396 3 the the DT cord-013590-pkm81fq1 396 4 α3-domain α3-domain NN cord-013590-pkm81fq1 396 5 led lead VBN cord-013590-pkm81fq1 396 6 to to IN cord-013590-pkm81fq1 396 7 ERK ERK NNP cord-013590-pkm81fq1 396 8 - - HYPH cord-013590-pkm81fq1 396 9 phosphorylation phosphorylation NN cord-013590-pkm81fq1 396 10 but but CC cord-013590-pkm81fq1 396 11 no no DT cord-013590-pkm81fq1 396 12 upregulation upregulation NN cord-013590-pkm81fq1 396 13 of of IN cord-013590-pkm81fq1 396 14 the the DT cord-013590-pkm81fq1 396 15 activation activation NN cord-013590-pkm81fq1 396 16 marker marker NN cord-013590-pkm81fq1 396 17 CD69 CD69 NNP cord-013590-pkm81fq1 396 18 , , , cord-013590-pkm81fq1 396 19 whereas whereas IN cord-013590-pkm81fq1 396 20 interaction interaction NN cord-013590-pkm81fq1 396 21 with with IN cord-013590-pkm81fq1 396 22 the the DT cord-013590-pkm81fq1 396 23 top top JJ cord-013590-pkm81fq1 396 24 - - HYPH cord-013590-pkm81fq1 396 25 side side NN cord-013590-pkm81fq1 396 26 of of IN cord-013590-pkm81fq1 396 27 MR-1 MR-1 NNP cord-013590-pkm81fq1 396 28 induced induce VBN cord-013590-pkm81fq1 396 29 full full JJ cord-013590-pkm81fq1 396 30 activation activation NN cord-013590-pkm81fq1 396 31 of of IN cord-013590-pkm81fq1 396 32 the the DT cord-013590-pkm81fq1 396 33 employed employ VBN cord-013590-pkm81fq1 396 34 reporter reporter NN cord-013590-pkm81fq1 396 35 cells cell NNS cord-013590-pkm81fq1 396 36 . . . cord-013590-pkm81fq1 397 1 Although although IN cord-013590-pkm81fq1 397 2 these these DT cord-013590-pkm81fq1 397 3 controversial controversial JJ cord-013590-pkm81fq1 397 4 binding binding NN cord-013590-pkm81fq1 397 5 modes mode NNS cord-013590-pkm81fq1 397 6 where where WRB cord-013590-pkm81fq1 397 7 observed observe VBN cord-013590-pkm81fq1 397 8 in in IN cord-013590-pkm81fq1 397 9 γδ γδ NNP cord-013590-pkm81fq1 397 10 T T NNP cord-013590-pkm81fq1 397 11 cells cell NNS cord-013590-pkm81fq1 397 12 ex ex NN cord-013590-pkm81fq1 397 13 vivo vivo NN cord-013590-pkm81fq1 397 14 from from IN cord-013590-pkm81fq1 397 15 several several JJ cord-013590-pkm81fq1 397 16 individuals individual NNS cord-013590-pkm81fq1 397 17 it -PRON- PRP cord-013590-pkm81fq1 397 18 is be VBZ cord-013590-pkm81fq1 397 19 unclear unclear JJ cord-013590-pkm81fq1 397 20 to to TO cord-013590-pkm81fq1 397 21 what what WDT cord-013590-pkm81fq1 397 22 extent extent NN cord-013590-pkm81fq1 397 23 this this DT cord-013590-pkm81fq1 397 24 applies apply VBZ cord-013590-pkm81fq1 397 25 also also RB cord-013590-pkm81fq1 397 26 to to IN cord-013590-pkm81fq1 397 27 physiological physiological JJ cord-013590-pkm81fq1 397 28 conditions condition NNS cord-013590-pkm81fq1 397 29 and and CC cord-013590-pkm81fq1 397 30 whether whether IN cord-013590-pkm81fq1 397 31 it -PRON- PRP cord-013590-pkm81fq1 397 32 is be VBZ cord-013590-pkm81fq1 397 33 a a DT cord-013590-pkm81fq1 397 34 singular singular JJ cord-013590-pkm81fq1 397 35 or or CC cord-013590-pkm81fq1 397 36 more more RBR cord-013590-pkm81fq1 397 37 general general JJ cord-013590-pkm81fq1 397 38 phenomenon phenomenon NN cord-013590-pkm81fq1 397 39 . . . cord-013590-pkm81fq1 398 1 During during IN cord-013590-pkm81fq1 398 2 the the DT cord-013590-pkm81fq1 398 3 past past JJ cord-013590-pkm81fq1 398 4 decades decade NNS cord-013590-pkm81fq1 398 5 , , , cord-013590-pkm81fq1 398 6 research research VB cord-013590-pkm81fq1 398 7 on on IN cord-013590-pkm81fq1 398 8 γδ γδ XX cord-013590-pkm81fq1 399 1 TCR TCR NNP cord-013590-pkm81fq1 399 2 ligands ligand NNS cord-013590-pkm81fq1 399 3 revealed reveal VBD cord-013590-pkm81fq1 399 4 a a DT cord-013590-pkm81fq1 399 5 plethora plethora NN cord-013590-pkm81fq1 399 6 of of IN cord-013590-pkm81fq1 399 7 diverse diverse JJ cord-013590-pkm81fq1 399 8 molecules molecule NNS cord-013590-pkm81fq1 399 9 that that WDT cord-013590-pkm81fq1 399 10 are be VBP cord-013590-pkm81fq1 399 11 recognized recognize VBN cord-013590-pkm81fq1 399 12 by by IN cord-013590-pkm81fq1 399 13 either either DT cord-013590-pkm81fq1 399 14 unique unique JJ cord-013590-pkm81fq1 399 15 specific specific JJ cord-013590-pkm81fq1 399 16 γδ γδ IN cord-013590-pkm81fq1 399 17 TCRs tcr NNS cord-013590-pkm81fq1 399 18 or or CC cord-013590-pkm81fq1 399 19 by by IN cord-013590-pkm81fq1 399 20 omni omni JJ cord-013590-pkm81fq1 399 21 - - HYPH cord-013590-pkm81fq1 399 22 present present JJ cord-013590-pkm81fq1 399 23 TCRs tcr NNS cord-013590-pkm81fq1 399 24 with with IN cord-013590-pkm81fq1 399 25 canonical canonical JJ cord-013590-pkm81fq1 399 26 γδ γδ NN cord-013590-pkm81fq1 399 27 rearrangements rearrangement NNS cord-013590-pkm81fq1 399 28 such such JJ cord-013590-pkm81fq1 399 29 as as IN cord-013590-pkm81fq1 399 30 Vγ9Vδ2 Vγ9Vδ2 NNS cord-013590-pkm81fq1 399 31 . . . cord-013590-pkm81fq1 400 1 Although although IN cord-013590-pkm81fq1 400 2 some some DT cord-013590-pkm81fq1 400 3 general general JJ cord-013590-pkm81fq1 400 4 patterns pattern NNS cord-013590-pkm81fq1 400 5 like like IN cord-013590-pkm81fq1 400 6 involvement involvement NN cord-013590-pkm81fq1 400 7 of of IN cord-013590-pkm81fq1 400 8 butyrophilins butyrophilin NNS cord-013590-pkm81fq1 400 9 and and CC cord-013590-pkm81fq1 400 10 BTNLs btnl NNS cord-013590-pkm81fq1 400 11 or or CC cord-013590-pkm81fq1 400 12 the the DT cord-013590-pkm81fq1 400 13 recognition recognition NN cord-013590-pkm81fq1 400 14 of of IN cord-013590-pkm81fq1 400 15 MHC MHC NNP cord-013590-pkm81fq1 400 16 - - HYPH cord-013590-pkm81fq1 400 17 like like JJ cord-013590-pkm81fq1 400 18 molecules molecule NNS cord-013590-pkm81fq1 400 19 can can MD cord-013590-pkm81fq1 400 20 be be VB cord-013590-pkm81fq1 400 21 observed observe VBN cord-013590-pkm81fq1 400 22 , , , cord-013590-pkm81fq1 400 23 an an DT cord-013590-pkm81fq1 400 24 overarching overarching JJ cord-013590-pkm81fq1 400 25 concept concept NN cord-013590-pkm81fq1 400 26 of of IN cord-013590-pkm81fq1 400 27 what what WP cord-013590-pkm81fq1 400 28 is be VBZ cord-013590-pkm81fq1 400 29 driving drive VBG cord-013590-pkm81fq1 400 30 the the DT cord-013590-pkm81fq1 400 31 activation activation NN cord-013590-pkm81fq1 400 32 of of IN cord-013590-pkm81fq1 400 33 γδ γδ NNP cord-013590-pkm81fq1 400 34 TCRs TCRs NNP cord-013590-pkm81fq1 400 35 is be VBZ cord-013590-pkm81fq1 400 36 still still RB cord-013590-pkm81fq1 400 37 missing miss VBG cord-013590-pkm81fq1 400 38 . . . cord-013590-pkm81fq1 401 1 Thus thus RB cord-013590-pkm81fq1 401 2 , , , cord-013590-pkm81fq1 401 3 in in IN cord-013590-pkm81fq1 401 4 order order NN cord-013590-pkm81fq1 401 5 to to TO cord-013590-pkm81fq1 401 6 broaden broaden VB cord-013590-pkm81fq1 401 7 our -PRON- PRP$ cord-013590-pkm81fq1 401 8 understanding understanding NN cord-013590-pkm81fq1 401 9 of of IN cord-013590-pkm81fq1 401 10 γδ γδ NNP cord-013590-pkm81fq1 401 11 TCR TCR NNP cord-013590-pkm81fq1 401 12 specificities specificity NNS cord-013590-pkm81fq1 401 13 and and CC cord-013590-pkm81fq1 401 14 their -PRON- PRP$ cord-013590-pkm81fq1 401 15 implications implication NNS cord-013590-pkm81fq1 401 16 in in IN cord-013590-pkm81fq1 401 17 health health NN cord-013590-pkm81fq1 401 18 and and CC cord-013590-pkm81fq1 401 19 disease disease NN cord-013590-pkm81fq1 401 20 , , , cord-013590-pkm81fq1 401 21 unbiased unbiased JJ cord-013590-pkm81fq1 401 22 and and CC cord-013590-pkm81fq1 401 23 large large JJ cord-013590-pkm81fq1 401 24 - - HYPH cord-013590-pkm81fq1 401 25 scale scale NN cord-013590-pkm81fq1 401 26 screening screening NN cord-013590-pkm81fq1 401 27 approaches approach NNS cord-013590-pkm81fq1 401 28 for for IN cord-013590-pkm81fq1 401 29 further further JJ cord-013590-pkm81fq1 401 30 ligands ligand NNS cord-013590-pkm81fq1 401 31 will will MD cord-013590-pkm81fq1 401 32 be be VB cord-013590-pkm81fq1 401 33 required require VBN cord-013590-pkm81fq1 401 34 . . . cord-013590-pkm81fq1 402 1 For for IN cord-013590-pkm81fq1 402 2 αβ αβ NNP cord-013590-pkm81fq1 402 3 TCRs TCRs NNP cord-013590-pkm81fq1 402 4 , , , cord-013590-pkm81fq1 402 5 a a DT cord-013590-pkm81fq1 402 6 multitude multitude NN cord-013590-pkm81fq1 402 7 of of IN cord-013590-pkm81fq1 402 8 these these DT cord-013590-pkm81fq1 402 9 methods method NNS cord-013590-pkm81fq1 402 10 is be VBZ cord-013590-pkm81fq1 402 11 already already RB cord-013590-pkm81fq1 402 12 established establish VBN cord-013590-pkm81fq1 402 13 as as IN cord-013590-pkm81fq1 402 14 recently recently RB cord-013590-pkm81fq1 402 15 reviewed review VBN cord-013590-pkm81fq1 402 16 by by IN cord-013590-pkm81fq1 402 17 Gerber Gerber NNP cord-013590-pkm81fq1 402 18 et et NNP cord-013590-pkm81fq1 402 19 al al NNP cord-013590-pkm81fq1 402 20 . . . cord-013590-pkm81fq1 403 1 139 139 CD cord-013590-pkm81fq1 404 1 A a DT cord-013590-pkm81fq1 404 2 prominent prominent JJ cord-013590-pkm81fq1 404 3 example example NN cord-013590-pkm81fq1 404 4 is be VBZ cord-013590-pkm81fq1 404 5 the the DT cord-013590-pkm81fq1 404 6 expression expression NN cord-013590-pkm81fq1 404 7 of of IN cord-013590-pkm81fq1 404 8 MHC MHC NNP cord-013590-pkm81fq1 404 9 - - HYPH cord-013590-pkm81fq1 404 10 αβ αβ NN cord-013590-pkm81fq1 404 11 TCR TCR NNP cord-013590-pkm81fq1 404 12 hybrids hybrid NNS cord-013590-pkm81fq1 404 13 ( ( -LRB- cord-013590-pkm81fq1 404 14 MCR MCR NNP cord-013590-pkm81fq1 404 15 ) ) -RRB- cord-013590-pkm81fq1 404 16 on on IN cord-013590-pkm81fq1 404 17 the the DT cord-013590-pkm81fq1 404 18 surface surface NN cord-013590-pkm81fq1 404 19 of of IN cord-013590-pkm81fq1 404 20 a a DT cord-013590-pkm81fq1 404 21 reporter reporter NN cord-013590-pkm81fq1 404 22 target target NN cord-013590-pkm81fq1 404 23 cell cell NN cord-013590-pkm81fq1 404 24 line line NN cord-013590-pkm81fq1 404 25 , , , cord-013590-pkm81fq1 404 26 which which WDT cord-013590-pkm81fq1 404 27 led lead VBD cord-013590-pkm81fq1 404 28 to to IN cord-013590-pkm81fq1 404 29 the the DT cord-013590-pkm81fq1 404 30 expression expression NN cord-013590-pkm81fq1 404 31 of of IN cord-013590-pkm81fq1 404 32 a a DT cord-013590-pkm81fq1 404 33 fluorescent fluorescent JJ cord-013590-pkm81fq1 404 34 reporter reporter NN cord-013590-pkm81fq1 404 35 gene gene NN cord-013590-pkm81fq1 404 36 construct construct VB cord-013590-pkm81fq1 404 37 upon upon IN cord-013590-pkm81fq1 404 38 functional functional JJ cord-013590-pkm81fq1 404 39 αβ αβ NN cord-013590-pkm81fq1 404 40 TCR TCR NNP cord-013590-pkm81fq1 404 41 binding bind VBG cord-013590-pkm81fq1 404 42 . . . cord-013590-pkm81fq1 405 1 140 140 CD cord-013590-pkm81fq1 406 1 To to IN cord-013590-pkm81fq1 406 2 γδ γδ NNP cord-013590-pkm81fq1 406 3 TCRs TCRs NNP cord-013590-pkm81fq1 406 4 however however RB cord-013590-pkm81fq1 406 5 , , , cord-013590-pkm81fq1 406 6 these these DT cord-013590-pkm81fq1 406 7 approaches approach NNS cord-013590-pkm81fq1 406 8 can can MD cord-013590-pkm81fq1 406 9 not not RB cord-013590-pkm81fq1 406 10 be be VB cord-013590-pkm81fq1 406 11 applied apply VBN cord-013590-pkm81fq1 406 12 since since IN cord-013590-pkm81fq1 406 13 no no DT cord-013590-pkm81fq1 406 14 general general JJ cord-013590-pkm81fq1 406 15 restrictive restrictive JJ cord-013590-pkm81fq1 406 16 molecule molecule NN cord-013590-pkm81fq1 406 17 such such JJ cord-013590-pkm81fq1 406 18 as as IN cord-013590-pkm81fq1 406 19 the the DT cord-013590-pkm81fq1 406 20 MHC MHC NNP cord-013590-pkm81fq1 406 21 exists exist VBZ cord-013590-pkm81fq1 406 22 or or CC cord-013590-pkm81fq1 406 23 has have VBZ cord-013590-pkm81fq1 406 24 at at RB cord-013590-pkm81fq1 406 25 least least JJS cord-013590-pkm81fq1 406 26 not not RB cord-013590-pkm81fq1 406 27 been be VBN cord-013590-pkm81fq1 406 28 identified identify VBN cord-013590-pkm81fq1 406 29 yet yet RB cord-013590-pkm81fq1 406 30 . . . cord-013590-pkm81fq1 407 1 Therefore therefore RB cord-013590-pkm81fq1 407 2 , , , cord-013590-pkm81fq1 407 3 the the DT cord-013590-pkm81fq1 407 4 emerging emerge VBG cord-013590-pkm81fq1 407 5 possibilities possibility NNS cord-013590-pkm81fq1 407 6 of of IN cord-013590-pkm81fq1 407 7 CRISPR CRISPR NNP cord-013590-pkm81fq1 407 8 - - HYPH cord-013590-pkm81fq1 407 9 Cas9 Cas9 NNP cord-013590-pkm81fq1 407 10 technology technology NN cord-013590-pkm81fq1 407 11 might may MD cord-013590-pkm81fq1 407 12 be be VB cord-013590-pkm81fq1 407 13 better well RBR cord-013590-pkm81fq1 407 14 applicable applicable JJ cord-013590-pkm81fq1 407 15 in in IN cord-013590-pkm81fq1 407 16 this this DT cord-013590-pkm81fq1 407 17 context context NN cord-013590-pkm81fq1 407 18 . . . cord-013590-pkm81fq1 408 1 With with IN cord-013590-pkm81fq1 408 2 the the DT cord-013590-pkm81fq1 408 3 appropriate appropriate JJ cord-013590-pkm81fq1 408 4 readout readout NN cord-013590-pkm81fq1 408 5 systems system NNS cord-013590-pkm81fq1 408 6 at at IN cord-013590-pkm81fq1 408 7 hand hand NN cord-013590-pkm81fq1 408 8 , , , cord-013590-pkm81fq1 408 9 such such JJ cord-013590-pkm81fq1 408 10 as as IN cord-013590-pkm81fq1 408 11 target target NN cord-013590-pkm81fq1 408 12 cell cell NN cord-013590-pkm81fq1 408 13 killing killing NN cord-013590-pkm81fq1 408 14 or or CC cord-013590-pkm81fq1 408 15 binding binding NN cord-013590-pkm81fq1 408 16 of of IN cord-013590-pkm81fq1 408 17 TCR TCR NNP cord-013590-pkm81fq1 408 18 - - HYPH cord-013590-pkm81fq1 408 19 tetramers tetramer NNS cord-013590-pkm81fq1 408 20 , , , cord-013590-pkm81fq1 408 21 genome genome NN cord-013590-pkm81fq1 408 22 - - HYPH cord-013590-pkm81fq1 408 23 wide wide JJ cord-013590-pkm81fq1 408 24 CRISPR CRISPR NNP cord-013590-pkm81fq1 408 25 libraries library NNS cord-013590-pkm81fq1 408 26 might may MD cord-013590-pkm81fq1 408 27 allow allow VB cord-013590-pkm81fq1 408 28 for for IN cord-013590-pkm81fq1 408 29 a a DT cord-013590-pkm81fq1 408 30 negative negative JJ cord-013590-pkm81fq1 408 31 selection selection NN cord-013590-pkm81fq1 408 32 of of IN cord-013590-pkm81fq1 408 33 those those DT cord-013590-pkm81fq1 408 34 cells cell NNS cord-013590-pkm81fq1 408 35 where where WRB cord-013590-pkm81fq1 408 36 the the DT cord-013590-pkm81fq1 408 37 target target NN cord-013590-pkm81fq1 408 38 for for IN cord-013590-pkm81fq1 408 39 the the DT cord-013590-pkm81fq1 408 40 γδ γδ NN cord-013590-pkm81fq1 409 1 TCR TCR NNP cord-013590-pkm81fq1 409 2 is be VBZ cord-013590-pkm81fq1 409 3 not not RB cord-013590-pkm81fq1 409 4 present present JJ cord-013590-pkm81fq1 409 5 anymore anymore RB cord-013590-pkm81fq1 409 6 . . . cord-013590-pkm81fq1 410 1 To to TO cord-013590-pkm81fq1 410 2 get get VB cord-013590-pkm81fq1 410 3 a a DT cord-013590-pkm81fq1 410 4 better well JJR cord-013590-pkm81fq1 410 5 understanding understanding NN cord-013590-pkm81fq1 410 6 of of IN cord-013590-pkm81fq1 410 7 γδ γδ NNP cord-013590-pkm81fq1 410 8 TCR TCR NNP cord-013590-pkm81fq1 410 9 activation activation NN cord-013590-pkm81fq1 410 10 , , , cord-013590-pkm81fq1 410 11 the the DT cord-013590-pkm81fq1 410 12 mere mere JJ cord-013590-pkm81fq1 410 13 identification identification NN cord-013590-pkm81fq1 410 14 of of IN cord-013590-pkm81fq1 410 15 ligands ligand NNS cord-013590-pkm81fq1 410 16 on on IN cord-013590-pkm81fq1 410 17 its -PRON- PRP$ cord-013590-pkm81fq1 410 18 own own JJ cord-013590-pkm81fq1 410 19 will will NN cord-013590-pkm81fq1 410 20 , , , cord-013590-pkm81fq1 410 21 however however RB cord-013590-pkm81fq1 410 22 , , , cord-013590-pkm81fq1 410 23 not not RB cord-013590-pkm81fq1 410 24 be be VB cord-013590-pkm81fq1 410 25 sufficient sufficient JJ cord-013590-pkm81fq1 410 26 . . . cord-013590-pkm81fq1 411 1 Especially especially RB cord-013590-pkm81fq1 411 2 for for IN cord-013590-pkm81fq1 411 3 host host NN cord-013590-pkm81fq1 411 4 - - HYPH cord-013590-pkm81fq1 411 5 cell cell NN cord-013590-pkm81fq1 411 6 - - HYPH cord-013590-pkm81fq1 411 7 derived derive VBN cord-013590-pkm81fq1 411 8 ligands ligand NNS cord-013590-pkm81fq1 411 9 for for IN cord-013590-pkm81fq1 411 10 the the DT cord-013590-pkm81fq1 411 11 γδ γδ NNP cord-013590-pkm81fq1 411 12 TCR TCR NNP cord-013590-pkm81fq1 411 13 , , , cord-013590-pkm81fq1 411 14 which which WDT cord-013590-pkm81fq1 411 15 might may MD cord-013590-pkm81fq1 411 16 be be VB cord-013590-pkm81fq1 411 17 directly directly RB cord-013590-pkm81fq1 411 18 recognized recognize VBN cord-013590-pkm81fq1 411 19 without without IN cord-013590-pkm81fq1 411 20 further further JJ cord-013590-pkm81fq1 411 21 processing processing NN cord-013590-pkm81fq1 411 22 , , , cord-013590-pkm81fq1 411 23 it -PRON- PRP cord-013590-pkm81fq1 411 24 is be VBZ cord-013590-pkm81fq1 411 25 essential essential JJ cord-013590-pkm81fq1 411 26 to to TO cord-013590-pkm81fq1 411 27 understand understand VB cord-013590-pkm81fq1 411 28 the the DT cord-013590-pkm81fq1 411 29 mechanisms mechanism NNS cord-013590-pkm81fq1 411 30 by by IN cord-013590-pkm81fq1 411 31 which which WDT cord-013590-pkm81fq1 411 32 a a DT cord-013590-pkm81fq1 411 33 discrimination discrimination NN cord-013590-pkm81fq1 411 34 between between IN cord-013590-pkm81fq1 411 35 normal normal JJ cord-013590-pkm81fq1 411 36 and and CC cord-013590-pkm81fq1 411 37 stress stress NN cord-013590-pkm81fq1 411 38 conditions condition NNS cord-013590-pkm81fq1 411 39 can can MD cord-013590-pkm81fq1 411 40 take take VB cord-013590-pkm81fq1 411 41 place place NN cord-013590-pkm81fq1 411 42 . . . cord-013590-pkm81fq1 412 1 Besides besides IN cord-013590-pkm81fq1 412 2 the the DT cord-013590-pkm81fq1 412 3 differential differential JJ cord-013590-pkm81fq1 412 4 expression expression NN cord-013590-pkm81fq1 412 5 of of IN cord-013590-pkm81fq1 412 6 the the DT cord-013590-pkm81fq1 412 7 respective respective JJ cord-013590-pkm81fq1 412 8 ligand ligand NN cord-013590-pkm81fq1 412 9 , , , cord-013590-pkm81fq1 412 10 co co JJ cord-013590-pkm81fq1 412 11 - - JJ cord-013590-pkm81fq1 412 12 stimulatory stimulatory JJ cord-013590-pkm81fq1 412 13 effects effect NNS cord-013590-pkm81fq1 412 14 by by IN cord-013590-pkm81fq1 412 15 other other JJ cord-013590-pkm81fq1 412 16 molecules molecule NNS cord-013590-pkm81fq1 412 17 , , , cord-013590-pkm81fq1 412 18 multimerization multimerization NN cord-013590-pkm81fq1 412 19 , , , cord-013590-pkm81fq1 412 20 conformational conformational JJ cord-013590-pkm81fq1 412 21 changes change NNS cord-013590-pkm81fq1 412 22 and and CC cord-013590-pkm81fq1 412 23 differential differential JJ cord-013590-pkm81fq1 412 24 glycosylation glycosylation NN cord-013590-pkm81fq1 412 25 of of IN cord-013590-pkm81fq1 412 26 the the DT cord-013590-pkm81fq1 412 27 putative putative JJ cord-013590-pkm81fq1 412 28 ligand ligand NN cord-013590-pkm81fq1 412 29 should should MD cord-013590-pkm81fq1 412 30 be be VB cord-013590-pkm81fq1 412 31 considered consider VBN cord-013590-pkm81fq1 412 32 and and CC cord-013590-pkm81fq1 412 33 investigated investigate VBN cord-013590-pkm81fq1 412 34 more more RBR cord-013590-pkm81fq1 412 35 in in IN cord-013590-pkm81fq1 412 36 this this DT cord-013590-pkm81fq1 412 37 context context NN cord-013590-pkm81fq1 412 38 . . . cord-013590-pkm81fq1 413 1 This this DT cord-013590-pkm81fq1 413 2 should should MD cord-013590-pkm81fq1 413 3 help help VB cord-013590-pkm81fq1 413 4 to to TO cord-013590-pkm81fq1 413 5 reconcile reconcile VB cord-013590-pkm81fq1 413 6 so so RB cord-013590-pkm81fq1 413 7 far far RB cord-013590-pkm81fq1 413 8 contradicting contradict VBG cord-013590-pkm81fq1 413 9 observations observation NNS cord-013590-pkm81fq1 413 10 in in IN cord-013590-pkm81fq1 413 11 γδ γδ XX cord-013590-pkm81fq1 414 1 TCR TCR NNP cord-013590-pkm81fq1 414 2 research research NN cord-013590-pkm81fq1 414 3 and and CC cord-013590-pkm81fq1 414 4 help help VB cord-013590-pkm81fq1 414 5 to to TO cord-013590-pkm81fq1 414 6 better better RB cord-013590-pkm81fq1 414 7 understand understand VB cord-013590-pkm81fq1 414 8 ligand ligand NN cord-013590-pkm81fq1 414 9 recognition recognition NN cord-013590-pkm81fq1 414 10 by by IN cord-013590-pkm81fq1 414 11 the the DT cord-013590-pkm81fq1 414 12 γδ γδ NNP cord-013590-pkm81fq1 414 13 TCR TCR NNP cord-013590-pkm81fq1 414 14 . . . cord-013590-pkm81fq1 415 1 Expression expression NN cord-013590-pkm81fq1 415 2 of of IN cord-013590-pkm81fq1 415 3 the the DT cord-013590-pkm81fq1 415 4 gamma gamma NN cord-013590-pkm81fq1 415 5 - - HYPH cord-013590-pkm81fq1 415 6 delta delta NN cord-013590-pkm81fq1 415 7 T t NN cord-013590-pkm81fq1 415 8 - - HYPH cord-013590-pkm81fq1 415 9 cell cell NN cord-013590-pkm81fq1 415 10 receptor receptor NN cord-013590-pkm81fq1 415 11 on on IN cord-013590-pkm81fq1 415 12 intestinal intestinal JJ cord-013590-pkm81fq1 415 13 CD8 CD8 NNP cord-013590-pkm81fq1 415 14 + + CC cord-013590-pkm81fq1 415 15 intraepithelial intraepithelial NNP cord-013590-pkm81fq1 415 16 lymphocytes lymphocyte NNS cord-013590-pkm81fq1 415 17 Homing homing NN cord-013590-pkm81fq1 415 18 of of IN cord-013590-pkm81fq1 415 19 a a DT cord-013590-pkm81fq1 415 20 gamma gamma NN cord-013590-pkm81fq1 415 21 delta delta NN cord-013590-pkm81fq1 415 22 thymocyte thymocyte NN cord-013590-pkm81fq1 415 23 subset subset VBN cord-013590-pkm81fq1 415 24 with with IN cord-013590-pkm81fq1 415 25 homogeneous homogeneous JJ cord-013590-pkm81fq1 415 26 T t NN cord-013590-pkm81fq1 415 27 - - HYPH cord-013590-pkm81fq1 415 28 cell cell NN cord-013590-pkm81fq1 415 29 receptors receptor NNS cord-013590-pkm81fq1 415 30 to to TO cord-013590-pkm81fq1 415 31 mucosal mucosal JJ cord-013590-pkm81fq1 415 32 epithelia epithelium NNS cord-013590-pkm81fq1 415 33 Selection selection NN cord-013590-pkm81fq1 415 34 by by IN cord-013590-pkm81fq1 415 35 two two CD cord-013590-pkm81fq1 415 36 powerful powerful JJ cord-013590-pkm81fq1 415 37 antigens antigen NNS cord-013590-pkm81fq1 415 38 may may MD cord-013590-pkm81fq1 415 39 account account VB cord-013590-pkm81fq1 415 40 for for IN cord-013590-pkm81fq1 415 41 the the DT cord-013590-pkm81fq1 415 42 presence presence NN cord-013590-pkm81fq1 415 43 of of IN cord-013590-pkm81fq1 415 44 the the DT cord-013590-pkm81fq1 415 45 major major JJ cord-013590-pkm81fq1 415 46 population population NN cord-013590-pkm81fq1 415 47 of of IN cord-013590-pkm81fq1 415 48 human human JJ cord-013590-pkm81fq1 415 49 peripheral peripheral JJ cord-013590-pkm81fq1 415 50 γ γ NNP cord-013590-pkm81fq1 415 51 / / SYM cord-013590-pkm81fq1 415 52 δ δ NN cord-013590-pkm81fq1 415 53 T t NN cord-013590-pkm81fq1 415 54 cells cell NNS cord-013590-pkm81fq1 415 55 Preferentially preferentially RB cord-013590-pkm81fq1 415 56 expanding expand VBG cord-013590-pkm81fq1 415 57 Vγ1 vγ1 NN cord-013590-pkm81fq1 415 58 + + CC cord-013590-pkm81fq1 415 59 γδ γδ NN cord-013590-pkm81fq1 415 60 T t NN cord-013590-pkm81fq1 415 61 cells cell NNS cord-013590-pkm81fq1 415 62 are be VBP cord-013590-pkm81fq1 415 63 associated associate VBN cord-013590-pkm81fq1 415 64 with with IN cord-013590-pkm81fq1 415 65 protective protective JJ cord-013590-pkm81fq1 415 66 immunity immunity NN cord-013590-pkm81fq1 415 67 against against IN cord-013590-pkm81fq1 415 68 Plasmodium Plasmodium NNP cord-013590-pkm81fq1 415 69 infection infection NN cord-013590-pkm81fq1 415 70 in in IN cord-013590-pkm81fq1 415 71 mice mouse NNS cord-013590-pkm81fq1 416 1 A a DT cord-013590-pkm81fq1 416 2 macrophage macrophage NN cord-013590-pkm81fq1 416 3 colony colony NN cord-013590-pkm81fq1 416 4 - - HYPH cord-013590-pkm81fq1 416 5 stimulating stimulate VBG cord-013590-pkm81fq1 416 6 - - HYPH cord-013590-pkm81fq1 416 7 factor factor NN cord-013590-pkm81fq1 416 8 - - HYPH cord-013590-pkm81fq1 416 9 producing produce VBG cord-013590-pkm81fq1 416 10 γδ γδ IN cord-013590-pkm81fq1 416 11 T t NN cord-013590-pkm81fq1 416 12 cell cell NN cord-013590-pkm81fq1 416 13 subset subset NN cord-013590-pkm81fq1 416 14 prevents prevent VBZ cord-013590-pkm81fq1 416 15 malarial malarial JJ cord-013590-pkm81fq1 416 16 parasitemic parasitemic NNP cord-013590-pkm81fq1 416 17 recurrence recurrence NN cord-013590-pkm81fq1 416 18 Implication Implication NNP cord-013590-pkm81fq1 416 19 of of IN cord-013590-pkm81fq1 416 20 gammadelta gammadelta NNP cord-013590-pkm81fq1 416 21 T T NNP cord-013590-pkm81fq1 416 22 cells cell NNS cord-013590-pkm81fq1 416 23 in in IN cord-013590-pkm81fq1 416 24 the the DT cord-013590-pkm81fq1 416 25 human human JJ cord-013590-pkm81fq1 416 26 immune immune JJ cord-013590-pkm81fq1 416 27 response response NN cord-013590-pkm81fq1 416 28 to to IN cord-013590-pkm81fq1 416 29 cytomegalovirus cytomegalovirus NNP cord-013590-pkm81fq1 416 30 Shared share VBN cord-013590-pkm81fq1 416 31 reactivity reactivity NN cord-013590-pkm81fq1 416 32 of of IN cord-013590-pkm81fq1 416 33 Vδ2 vδ2 NN cord-013590-pkm81fq1 416 34 neg neg NNP cord-013590-pkm81fq1 416 35 γδ γδ XX cord-013590-pkm81fq1 416 36 T T NNP cord-013590-pkm81fq1 416 37 cells cell NNS cord-013590-pkm81fq1 416 38 against against IN cord-013590-pkm81fq1 416 39 cytomegalovirusinfected cytomegalovirusinfecte VBN cord-013590-pkm81fq1 416 40 cells cell NNS cord-013590-pkm81fq1 416 41 and and CC cord-013590-pkm81fq1 416 42 tumor tumor NN cord-013590-pkm81fq1 416 43 intestinal intestinal JJ cord-013590-pkm81fq1 416 44 epithelial epithelial JJ cord-013590-pkm81fq1 416 45 cells cell NNS cord-013590-pkm81fq1 416 46 Effector Effector NNP cord-013590-pkm81fq1 416 47 functions function NNS cord-013590-pkm81fq1 416 48 and and CC cord-013590-pkm81fq1 416 49 control control NN cord-013590-pkm81fq1 416 50 of of IN cord-013590-pkm81fq1 416 51 human human NN cord-013590-pkm81fq1 416 52 γδ γδ IN cord-013590-pkm81fq1 416 53 T t NN cord-013590-pkm81fq1 416 54 - - HYPH cord-013590-pkm81fq1 416 55 cell cell NN cord-013590-pkm81fq1 416 56 activation activation NN cord-013590-pkm81fq1 416 57 Harnessing harness VBG cord-013590-pkm81fq1 416 58 γδ γδ IN cord-013590-pkm81fq1 416 59 T t NN cord-013590-pkm81fq1 416 60 cells cell NNS cord-013590-pkm81fq1 416 61 in in IN cord-013590-pkm81fq1 416 62 anticancer anticancer JJ cord-013590-pkm81fq1 416 63 immunotherapy immunotherapy NN cord-013590-pkm81fq1 416 64 Recognition Recognition NNP cord-013590-pkm81fq1 416 65 of of IN cord-013590-pkm81fq1 416 66 stress stress NN cord-013590-pkm81fq1 416 67 - - HYPH cord-013590-pkm81fq1 416 68 induced induce VBN cord-013590-pkm81fq1 416 69 MHC MHC NNP cord-013590-pkm81fq1 416 70 molecules molecule NNS cord-013590-pkm81fq1 416 71 by by IN cord-013590-pkm81fq1 416 72 intestinal intestinal JJ cord-013590-pkm81fq1 416 73 epithelial epithelial NN cord-013590-pkm81fq1 416 74 γδ γδ IN cord-013590-pkm81fq1 416 75 T t NN cord-013590-pkm81fq1 416 76 cells cell NNS cord-013590-pkm81fq1 416 77 Translating translate VBG cord-013590-pkm81fq1 416 78 gammadelta gammadelta NNP cord-013590-pkm81fq1 416 79 ( ( -LRB- cord-013590-pkm81fq1 416 80 γδ γδ NN cord-013590-pkm81fq1 416 81 ) ) -RRB- cord-013590-pkm81fq1 416 82 T t NN cord-013590-pkm81fq1 416 83 cells cell NNS cord-013590-pkm81fq1 416 84 and and CC cord-013590-pkm81fq1 416 85 their -PRON- PRP$ cord-013590-pkm81fq1 416 86 receptors receptor NNS cord-013590-pkm81fq1 416 87 into into IN cord-013590-pkm81fq1 416 88 cancer cancer NN cord-013590-pkm81fq1 416 89 cell cell NN cord-013590-pkm81fq1 416 90 therapies therapy NNS cord-013590-pkm81fq1 417 1 CD1-restricted CD1-restricted NNP cord-013590-pkm81fq1 417 2 recognition recognition NN cord-013590-pkm81fq1 417 3 of of IN cord-013590-pkm81fq1 417 4 exogenous exogenous JJ cord-013590-pkm81fq1 417 5 and and CC cord-013590-pkm81fq1 417 6 self self NN cord-013590-pkm81fq1 417 7 - - HYPH cord-013590-pkm81fq1 417 8 lipid lipid NN cord-013590-pkm81fq1 417 9 antigens antigen NNS cord-013590-pkm81fq1 417 10 by by IN cord-013590-pkm81fq1 417 11 duodenal duodenal NN cord-013590-pkm81fq1 417 12 γδ γδ XX cord-013590-pkm81fq1 418 1 + + CC cord-013590-pkm81fq1 419 1 T T NNP cord-013590-pkm81fq1 419 2 lymphocytes lymphocyte NNS cord-013590-pkm81fq1 420 1 The the DT cord-013590-pkm81fq1 420 2 NKG2D nkg2d NN cord-013590-pkm81fq1 420 3 ligand ligand NN cord-013590-pkm81fq1 420 4 ULBP4 ulbp4 NN cord-013590-pkm81fq1 420 5 binds bind VBZ cord-013590-pkm81fq1 420 6 to to IN cord-013590-pkm81fq1 420 7 TCRγ9 TCRγ9 NNP cord-013590-pkm81fq1 420 8 / / SYM cord-013590-pkm81fq1 420 9 δ2 δ2 NN cord-013590-pkm81fq1 420 10 and and CC cord-013590-pkm81fq1 420 11 induces induce VBZ cord-013590-pkm81fq1 420 12 cytotoxicity cytotoxicity NN cord-013590-pkm81fq1 420 13 to to IN cord-013590-pkm81fq1 420 14 tumor tumor NN cord-013590-pkm81fq1 420 15 cells cell NNS cord-013590-pkm81fq1 420 16 through through IN cord-013590-pkm81fq1 420 17 both both CC cord-013590-pkm81fq1 420 18 TCRγδ tcrγδ JJ cord-013590-pkm81fq1 420 19 and and CC cord-013590-pkm81fq1 420 20 NKG2D NKG2D NNP cord-013590-pkm81fq1 420 21 Human Human NNP cord-013590-pkm81fq1 420 22 γδ γδ IN cord-013590-pkm81fq1 420 23 T t NN cord-013590-pkm81fq1 420 24 cells cell NNS cord-013590-pkm81fq1 420 25 are be VBP cord-013590-pkm81fq1 420 26 quickly quickly RB cord-013590-pkm81fq1 420 27 reconstituted reconstitute VBN cord-013590-pkm81fq1 420 28 after after IN cord-013590-pkm81fq1 420 29 stem stem NN cord-013590-pkm81fq1 420 30 - - HYPH cord-013590-pkm81fq1 420 31 cell cell NN cord-013590-pkm81fq1 420 32 transplantation transplantation NN cord-013590-pkm81fq1 420 33 and and CC cord-013590-pkm81fq1 420 34 show show VB cord-013590-pkm81fq1 420 35 adaptive adaptive JJ cord-013590-pkm81fq1 420 36 clonal clonal JJ cord-013590-pkm81fq1 420 37 expansion expansion NN cord-013590-pkm81fq1 420 38 in in IN cord-013590-pkm81fq1 420 39 response response NN cord-013590-pkm81fq1 420 40 to to IN cord-013590-pkm81fq1 420 41 viral viral JJ cord-013590-pkm81fq1 420 42 infection infection NN cord-013590-pkm81fq1 420 43 Clonal Clonal NNP cord-013590-pkm81fq1 420 44 selection selection NN cord-013590-pkm81fq1 420 45 in in IN cord-013590-pkm81fq1 420 46 the the DT cord-013590-pkm81fq1 420 47 human human JJ cord-013590-pkm81fq1 420 48 Vδ1 Vδ1 NNP cord-013590-pkm81fq1 420 49 T T NNP cord-013590-pkm81fq1 420 50 cell cell NN cord-013590-pkm81fq1 420 51 repertoire repertoire NN cord-013590-pkm81fq1 421 1 indicates indicate VBZ cord-013590-pkm81fq1 421 2 γδ γδ IN cord-013590-pkm81fq1 421 3 TCR TCR NNP cord-013590-pkm81fq1 421 4 - - HYPH cord-013590-pkm81fq1 421 5 dependent dependent JJ cord-013590-pkm81fq1 421 6 adaptive adaptive JJ cord-013590-pkm81fq1 421 7 immune immune JJ cord-013590-pkm81fq1 421 8 surveillance surveillance NN cord-013590-pkm81fq1 421 9 Somatic somatic JJ cord-013590-pkm81fq1 421 10 hypermutation hypermutation NN cord-013590-pkm81fq1 421 11 of of IN cord-013590-pkm81fq1 422 1 T T NNP cord-013590-pkm81fq1 422 2 cell cell NN cord-013590-pkm81fq1 422 3 receptor receptor NN cord-013590-pkm81fq1 422 4 α α NN cord-013590-pkm81fq1 422 5 chain chain NN cord-013590-pkm81fq1 422 6 contributes contribute VBZ cord-013590-pkm81fq1 422 7 to to IN cord-013590-pkm81fq1 422 8 selection selection NN cord-013590-pkm81fq1 422 9 in in IN cord-013590-pkm81fq1 422 10 nurse nurse NN cord-013590-pkm81fq1 422 11 shark shark NN cord-013590-pkm81fq1 422 12 thymus thymus NN cord-013590-pkm81fq1 423 1 The the DT cord-013590-pkm81fq1 423 2 innate innate JJ cord-013590-pkm81fq1 423 3 biologies biology NNS cord-013590-pkm81fq1 423 4 of of IN cord-013590-pkm81fq1 423 5 adaptive adaptive JJ cord-013590-pkm81fq1 423 6 antigen antigen NN cord-013590-pkm81fq1 423 7 receptors receptor NNS cord-013590-pkm81fq1 423 8 γδ γδ IN cord-013590-pkm81fq1 423 9 TCR TCR NNP cord-013590-pkm81fq1 423 10 ligands ligand NNS cord-013590-pkm81fq1 423 11 : : : cord-013590-pkm81fq1 423 12 the the DT cord-013590-pkm81fq1 423 13 quest quest NN cord-013590-pkm81fq1 423 14 to to TO cord-013590-pkm81fq1 423 15 solve solve VB cord-013590-pkm81fq1 423 16 a a DT cord-013590-pkm81fq1 423 17 500-millionyear 500-millionyear CD cord-013590-pkm81fq1 423 18 - - HYPH cord-013590-pkm81fq1 423 19 old old JJ cord-013590-pkm81fq1 423 20 mystery mystery NN cord-013590-pkm81fq1 423 21 γδ γδ IN cord-013590-pkm81fq1 423 22 T t NN cord-013590-pkm81fq1 423 23 cell cell NN cord-013590-pkm81fq1 423 24 responses response NNS cord-013590-pkm81fq1 423 25 : : : cord-013590-pkm81fq1 423 26 How how WRB cord-013590-pkm81fq1 423 27 many many JJ cord-013590-pkm81fq1 423 28 ligands ligand NNS cord-013590-pkm81fq1 423 29 will will MD cord-013590-pkm81fq1 423 30 it -PRON- PRP cord-013590-pkm81fq1 423 31 take take VB cord-013590-pkm81fq1 423 32 till till IN cord-013590-pkm81fq1 423 33 we -PRON- PRP cord-013590-pkm81fq1 423 34 know know VBP cord-013590-pkm81fq1 423 35 ? ? . cord-013590-pkm81fq1 424 1 Semin Semin NNP cord-013590-pkm81fq1 424 2 Most Most NNP cord-013590-pkm81fq1 424 3 gamma gamma NN cord-013590-pkm81fq1 424 4 delta delta NN cord-013590-pkm81fq1 424 5 T t NN cord-013590-pkm81fq1 424 6 cells cell NNS cord-013590-pkm81fq1 424 7 develop develop VBP cord-013590-pkm81fq1 424 8 normally normally RB cord-013590-pkm81fq1 424 9 in in IN cord-013590-pkm81fq1 424 10 the the DT cord-013590-pkm81fq1 424 11 absence absence NN cord-013590-pkm81fq1 424 12 of of IN cord-013590-pkm81fq1 424 13 MHC MHC NNP cord-013590-pkm81fq1 424 14 class class NN cord-013590-pkm81fq1 424 15 II II NNP cord-013590-pkm81fq1 424 16 molecules molecule NNS cord-013590-pkm81fq1 424 17 Most most RBS cord-013590-pkm81fq1 424 18 γδ γδ IN cord-013590-pkm81fq1 424 19 T t NN cord-013590-pkm81fq1 424 20 cells cell NNS cord-013590-pkm81fq1 424 21 develop develop VBP cord-013590-pkm81fq1 424 22 normally normally RB cord-013590-pkm81fq1 424 23 in in IN cord-013590-pkm81fq1 424 24 β2-microglobulin β2-microglobulin NN cord-013590-pkm81fq1 424 25 - - HYPH cord-013590-pkm81fq1 424 26 deficient deficient JJ cord-013590-pkm81fq1 424 27 mice mouse NNS cord-013590-pkm81fq1 424 28 Structure structure NN cord-013590-pkm81fq1 424 29 and and CC cord-013590-pkm81fq1 424 30 specificity specificity NN cord-013590-pkm81fq1 424 31 of of IN cord-013590-pkm81fq1 424 32 a a DT cord-013590-pkm81fq1 424 33 class class NN cord-013590-pkm81fq1 424 34 II II NNP cord-013590-pkm81fq1 424 35 MHC MHC NNP cord-013590-pkm81fq1 424 36 alloreactive alloreactive NN cord-013590-pkm81fq1 424 37 γδ γδ IN cord-013590-pkm81fq1 424 38 T t NN cord-013590-pkm81fq1 424 39 cell cell NN cord-013590-pkm81fq1 424 40 receptor receptor NN cord-013590-pkm81fq1 424 41 heterodimer heterodimer NN cord-013590-pkm81fq1 424 42 Identification identification NN cord-013590-pkm81fq1 424 43 of of IN cord-013590-pkm81fq1 424 44 a a DT cord-013590-pkm81fq1 424 45 tumor tumor NN cord-013590-pkm81fq1 424 46 - - HYPH cord-013590-pkm81fq1 424 47 specific specific JJ cord-013590-pkm81fq1 424 48 allo allo NN cord-013590-pkm81fq1 424 49 - - HYPH cord-013590-pkm81fq1 424 50 HLA hla NN cord-013590-pkm81fq1 424 51 - - HYPH cord-013590-pkm81fq1 424 52 restricted restrict VBN cord-013590-pkm81fq1 424 53 gdTCR gdtcr NN cord-013590-pkm81fq1 425 1 CD1d cd1d NN cord-013590-pkm81fq1 425 2 - - HYPH cord-013590-pkm81fq1 425 3 lipid lipid NN cord-013590-pkm81fq1 425 4 antigen antigen NN cord-013590-pkm81fq1 425 5 recognition recognition NN cord-013590-pkm81fq1 425 6 by by IN cord-013590-pkm81fq1 425 7 the the DT cord-013590-pkm81fq1 425 8 γδ γδ NN cord-013590-pkm81fq1 425 9 TCR TCR NNP cord-013590-pkm81fq1 425 10 Cytomegalovirus Cytomegalovirus NNP cord-013590-pkm81fq1 425 11 and and CC cord-013590-pkm81fq1 425 12 tumor tumor NN cord-013590-pkm81fq1 425 13 stress stress NN cord-013590-pkm81fq1 425 14 surveillance surveillance NN cord-013590-pkm81fq1 425 15 by by IN cord-013590-pkm81fq1 425 16 binding bind VBG cord-013590-pkm81fq1 425 17 of of IN cord-013590-pkm81fq1 425 18 a a DT cord-013590-pkm81fq1 425 19 human human NN cord-013590-pkm81fq1 425 20 γδ γδ IN cord-013590-pkm81fq1 425 21 T t NN cord-013590-pkm81fq1 425 22 cell cell NN cord-013590-pkm81fq1 425 23 antigen antigen NN cord-013590-pkm81fq1 425 24 receptor receptor NN cord-013590-pkm81fq1 425 25 to to IN cord-013590-pkm81fq1 425 26 endothelial endothelial JJ cord-013590-pkm81fq1 425 27 protein protein NN cord-013590-pkm81fq1 425 28 C c NN cord-013590-pkm81fq1 425 29 receptor receptor NN cord-013590-pkm81fq1 425 30 Positive positive JJ cord-013590-pkm81fq1 425 31 selection selection NN cord-013590-pkm81fq1 425 32 is be VBZ cord-013590-pkm81fq1 425 33 not not RB cord-013590-pkm81fq1 425 34 required require VBN cord-013590-pkm81fq1 425 35 for for IN cord-013590-pkm81fq1 425 36 thymic thymic JJ cord-013590-pkm81fq1 425 37 maturation maturation NN cord-013590-pkm81fq1 425 38 of of IN cord-013590-pkm81fq1 425 39 transgenic transgenic JJ cord-013590-pkm81fq1 425 40 γδ γδ IN cord-013590-pkm81fq1 425 41 T t NN cord-013590-pkm81fq1 425 42 cells cell NNS cord-013590-pkm81fq1 425 43 Blockade Blockade NNP cord-013590-pkm81fq1 425 44 of of IN cord-013590-pkm81fq1 425 45 transgenic transgenic JJ cord-013590-pkm81fq1 425 46 gamma gamma NN cord-013590-pkm81fq1 425 47 delta delta NNP cord-013590-pkm81fq1 425 48 T T NNP cord-013590-pkm81fq1 425 49 cell cell NN cord-013590-pkm81fq1 425 50 development development NN cord-013590-pkm81fq1 425 51 in in IN cord-013590-pkm81fq1 425 52 beta beta JJ cord-013590-pkm81fq1 425 53 2-microglobulin 2-microglobulin CD cord-013590-pkm81fq1 425 54 deficient deficient JJ cord-013590-pkm81fq1 425 55 mice mouse NNS cord-013590-pkm81fq1 425 56 Requirement Requirement NNP cord-013590-pkm81fq1 425 57 for for IN cord-013590-pkm81fq1 425 58 positive positive JJ cord-013590-pkm81fq1 425 59 selection selection NN cord-013590-pkm81fq1 425 60 of of IN cord-013590-pkm81fq1 425 61 γδ γδ IN cord-013590-pkm81fq1 425 62 receptor receptor NN cord-013590-pkm81fq1 425 63 - - HYPH cord-013590-pkm81fq1 425 64 bearing bear VBG cord-013590-pkm81fq1 425 65 T T NNP cord-013590-pkm81fq1 425 66 cells cell NNS cord-013590-pkm81fq1 425 67 Role role NN cord-013590-pkm81fq1 425 68 of of IN cord-013590-pkm81fq1 425 69 a a DT cord-013590-pkm81fq1 425 70 selecting select VBG cord-013590-pkm81fq1 425 71 ligand ligand NN cord-013590-pkm81fq1 425 72 in in IN cord-013590-pkm81fq1 425 73 shaping shape VBG cord-013590-pkm81fq1 425 74 the the DT cord-013590-pkm81fq1 425 75 murine murine JJ cord-013590-pkm81fq1 425 76 γδ γδ NNP cord-013590-pkm81fq1 425 77 - - HYPH cord-013590-pkm81fq1 425 78 TCR TCR NNP cord-013590-pkm81fq1 425 79 repertoire repertoire NN cord-013590-pkm81fq1 425 80 Structure structure NN cord-013590-pkm81fq1 425 81 and and CC cord-013590-pkm81fq1 425 82 specificity specificity NN cord-013590-pkm81fq1 425 83 of of IN cord-013590-pkm81fq1 425 84 T T NNP cord-013590-pkm81fq1 425 85 cell cell NN cord-013590-pkm81fq1 425 86 receptor receptor NN cord-013590-pkm81fq1 425 87 γ/ γ/ NNP cord-013590-pkm81fq1 426 1 δ δ NNP cord-013590-pkm81fq1 426 2 on on IN cord-013590-pkm81fq1 426 3 major major JJ cord-013590-pkm81fq1 426 4 histocompatibility histocompatibility NN cord-013590-pkm81fq1 426 5 complex complex JJ cord-013590-pkm81fq1 426 6 antigen antigen NN cord-013590-pkm81fq1 426 7 - - HYPH cord-013590-pkm81fq1 426 8 specific specific JJ cord-013590-pkm81fq1 426 9 CD3 cd3 NN cord-013590-pkm81fq1 427 1 + + CC cord-013590-pkm81fq1 428 1 , , , cord-013590-pkm81fq1 428 2 CD4− CD4− NNP cord-013590-pkm81fq1 428 3 , , , cord-013590-pkm81fq1 428 4 CD8− CD8− NNP cord-013590-pkm81fq1 428 5 T T NNP cord-013590-pkm81fq1 428 6 lymphocytes lymphocyte VBZ cord-013590-pkm81fq1 428 7 Specificity Specificity NNP cord-013590-pkm81fq1 428 8 of of IN cord-013590-pkm81fq1 428 9 human human JJ cord-013590-pkm81fq1 428 10 T t NN cord-013590-pkm81fq1 428 11 lymphocytes lymphocyte NNS cord-013590-pkm81fq1 428 12 expressing express VBG cord-013590-pkm81fq1 428 13 a a DT cord-013590-pkm81fq1 428 14 γ γ NN cord-013590-pkm81fq1 428 15 / / SYM cord-013590-pkm81fq1 428 16 δ δ NN cord-013590-pkm81fq1 428 17 T T NNP cord-013590-pkm81fq1 428 18 cell cell NN cord-013590-pkm81fq1 428 19 antigen antigen NN cord-013590-pkm81fq1 428 20 receptor receptor NN cord-013590-pkm81fq1 428 21 . . . cord-013590-pkm81fq1 429 1 Recognition recognition NN cord-013590-pkm81fq1 429 2 of of IN cord-013590-pkm81fq1 429 3 a a DT cord-013590-pkm81fq1 429 4 polymorphic polymorphic JJ cord-013590-pkm81fq1 429 5 determinant determinant NN cord-013590-pkm81fq1 429 6 of of IN cord-013590-pkm81fq1 429 7 HLA HLA NNP cord-013590-pkm81fq1 429 8 class class NN cord-013590-pkm81fq1 430 1 I -PRON- PRP cord-013590-pkm81fq1 430 2 molecules molecule NNS cord-013590-pkm81fq1 430 3 by by IN cord-013590-pkm81fq1 430 4 a a DT cord-013590-pkm81fq1 430 5 γ γ NN cord-013590-pkm81fq1 430 6 / / SYM cord-013590-pkm81fq1 430 7 δ δ NN cord-013590-pkm81fq1 430 8 clone clone NN cord-013590-pkm81fq1 430 9 Identification identification NN cord-013590-pkm81fq1 430 10 of of IN cord-013590-pkm81fq1 430 11 a a DT cord-013590-pkm81fq1 430 12 novel novel JJ cord-013590-pkm81fq1 430 13 HLA HLA NNP cord-013590-pkm81fq1 430 14 - - HYPH cord-013590-pkm81fq1 430 15 B27 b27 NN cord-013590-pkm81fq1 430 16 subtype subtype NN cord-013590-pkm81fq1 430 17 by by IN cord-013590-pkm81fq1 430 18 restriction restriction NN cord-013590-pkm81fq1 430 19 analysis analysis NN cord-013590-pkm81fq1 430 20 of of IN cord-013590-pkm81fq1 430 21 a a DT cord-013590-pkm81fq1 430 22 cytotoxic cytotoxic JJ cord-013590-pkm81fq1 430 23 gamma gamma NN cord-013590-pkm81fq1 430 24 delta delta NN cord-013590-pkm81fq1 430 25 T T NNP cord-013590-pkm81fq1 430 26 cell cell NN cord-013590-pkm81fq1 430 27 clone clone NN cord-013590-pkm81fq1 430 28 Cytotoxic Cytotoxic NNP cord-013590-pkm81fq1 430 29 activity activity NN cord-013590-pkm81fq1 430 30 and and CC cord-013590-pkm81fq1 430 31 lymphokine lymphokine NN cord-013590-pkm81fq1 430 32 production production NN cord-013590-pkm81fq1 430 33 of of IN cord-013590-pkm81fq1 430 34 T T NNP cord-013590-pkm81fq1 430 35 cell cell NN cord-013590-pkm81fq1 430 36 receptor receptor NN cord-013590-pkm81fq1 430 37 ( ( -LRB- cord-013590-pkm81fq1 430 38 TCR)-αβ+ TCR)-αβ+ NNP cord-013590-pkm81fq1 430 39 and and CC cord-013590-pkm81fq1 430 40 TCR TCR NNP cord-013590-pkm81fq1 430 41 - - HYPH cord-013590-pkm81fq1 430 42 γδ+ γδ+ NN cord-013590-pkm81fq1 430 43 cytotoxic cytotoxic JJ cord-013590-pkm81fq1 430 44 T t NN cord-013590-pkm81fq1 430 45 lymphocyte lymphocyte NN cord-013590-pkm81fq1 430 46 ( ( -LRB- cord-013590-pkm81fq1 430 47 CTL CTL NNP cord-013590-pkm81fq1 430 48 ) ) -RRB- cord-013590-pkm81fq1 430 49 clones clone NNS cord-013590-pkm81fq1 430 50 recognizing recognize VBG cord-013590-pkm81fq1 430 51 HLA HLA NNP cord-013590-pkm81fq1 430 52 - - HYPH cord-013590-pkm81fq1 430 53 A2 A2 NNP cord-013590-pkm81fq1 430 54 and and CC cord-013590-pkm81fq1 430 55 HLA HLA NNP cord-013590-pkm81fq1 430 56 - - HYPH cord-013590-pkm81fq1 430 57 A2 A2 NNP cord-013590-pkm81fq1 430 58 mutants mutant NNS cord-013590-pkm81fq1 430 59 . . . cord-013590-pkm81fq1 431 1 Recognition Recognition NNP cord-013590-pkm81fq1 431 2 of of IN cord-013590-pkm81fq1 431 3 TCR TCR NNP cord-013590-pkm81fq1 431 4 - - HYPH cord-013590-pkm81fq1 431 5 γδ+ γδ+ NNP cord-013590-pkm81fq1 431 6 CTL CTL NNP cord-013590-pkm81fq1 431 7 clones clone NNS cord-013590-pkm81fq1 431 8 is be VBZ cord-013590-pkm81fq1 431 9 affected affect VBN cord-013590-pkm81fq1 431 10 by by IN cord-013590-pkm81fq1 431 11 mutations mutation NNS cord-013590-pkm81fq1 431 12 at at IN cord-013590-pkm81fq1 431 13 positions position NNS cord-013590-pkm81fq1 431 14 152 152 CD cord-013590-pkm81fq1 431 15 and and CC cord-013590-pkm81fq1 431 16 156 156 CD cord-013590-pkm81fq1 431 17 Generation generation NN cord-013590-pkm81fq1 431 18 and and CC cord-013590-pkm81fq1 431 19 molecular molecular JJ cord-013590-pkm81fq1 431 20 recognition recognition NN cord-013590-pkm81fq1 431 21 of of IN cord-013590-pkm81fq1 431 22 melanomaassociated melanomaassociate VBN cord-013590-pkm81fq1 431 23 antigen antigen NN cord-013590-pkm81fq1 431 24 - - HYPH cord-013590-pkm81fq1 431 25 specific specific JJ cord-013590-pkm81fq1 431 26 human human NN cord-013590-pkm81fq1 431 27 γδ γδ IN cord-013590-pkm81fq1 431 28 T t NN cord-013590-pkm81fq1 431 29 cells cell NNS cord-013590-pkm81fq1 431 30 Self self NN cord-013590-pkm81fq1 431 31 - - HYPH cord-013590-pkm81fq1 431 32 recognition recognition NN cord-013590-pkm81fq1 431 33 of of IN cord-013590-pkm81fq1 431 34 CD1 CD1 NNP cord-013590-pkm81fq1 431 35 by by IN cord-013590-pkm81fq1 431 36 γ γ NN cord-013590-pkm81fq1 431 37 / / SYM cord-013590-pkm81fq1 431 38 δ δ NN cord-013590-pkm81fq1 431 39 T T NNP cord-013590-pkm81fq1 431 40 cells cell NNS cord-013590-pkm81fq1 431 41 : : : cord-013590-pkm81fq1 431 42 implications implication NNS cord-013590-pkm81fq1 431 43 for for IN cord-013590-pkm81fq1 431 44 innate innate JJ cord-013590-pkm81fq1 431 45 immunity immunity NN cord-013590-pkm81fq1 431 46 Recognition Recognition NNP cord-013590-pkm81fq1 431 47 of of IN cord-013590-pkm81fq1 431 48 pollen pollen NN cord-013590-pkm81fq1 431 49 - - HYPH cord-013590-pkm81fq1 431 50 derived derive VBN cord-013590-pkm81fq1 431 51 phosphatidyl phosphatidyl NN cord-013590-pkm81fq1 431 52 - - HYPH cord-013590-pkm81fq1 431 53 ethanolamine ethanolamine NN cord-013590-pkm81fq1 431 54 by by IN cord-013590-pkm81fq1 431 55 human human JJ cord-013590-pkm81fq1 431 56 CD1d cd1d NN cord-013590-pkm81fq1 431 57 - - HYPH cord-013590-pkm81fq1 431 58 restricted restrict VBN cord-013590-pkm81fq1 431 59 γδ γδ IN cord-013590-pkm81fq1 431 60 T t NN cord-013590-pkm81fq1 431 61 cells cell NNS cord-013590-pkm81fq1 431 62 Cardiolipin Cardiolipin NNP cord-013590-pkm81fq1 431 63 binds bind VBZ cord-013590-pkm81fq1 431 64 to to IN cord-013590-pkm81fq1 431 65 CD1d CD1d NNP cord-013590-pkm81fq1 431 66 and and CC cord-013590-pkm81fq1 431 67 stimulates stimulate VBZ cord-013590-pkm81fq1 431 68 CD1d cd1d NN cord-013590-pkm81fq1 431 69 - - HYPH cord-013590-pkm81fq1 431 70 restricted restrict VBN cord-013590-pkm81fq1 431 71 γδ γδ IN cord-013590-pkm81fq1 431 72 T t NN cord-013590-pkm81fq1 431 73 cells cell NNS cord-013590-pkm81fq1 431 74 in in IN cord-013590-pkm81fq1 431 75 the the DT cord-013590-pkm81fq1 431 76 normal normal JJ cord-013590-pkm81fq1 431 77 murine murine JJ cord-013590-pkm81fq1 431 78 repertoire repertoire NN cord-013590-pkm81fq1 432 1 Molecular molecular JJ cord-013590-pkm81fq1 432 2 analysis analysis NN cord-013590-pkm81fq1 432 3 of of IN cord-013590-pkm81fq1 432 4 lipid lipid NN cord-013590-pkm81fq1 432 5 - - HYPH cord-013590-pkm81fq1 432 6 reactive reactive JJ cord-013590-pkm81fq1 432 7 Vδ1 vδ1 NN cord-013590-pkm81fq1 432 8 γδ γδ IN cord-013590-pkm81fq1 432 9 T t NN cord-013590-pkm81fq1 432 10 cells cell NNS cord-013590-pkm81fq1 432 11 identified identify VBN cord-013590-pkm81fq1 432 12 by by IN cord-013590-pkm81fq1 432 13 CD1c CD1c NNP cord-013590-pkm81fq1 432 14 tetramers tetramer NNS cord-013590-pkm81fq1 432 15 Crystal Crystal NNP cord-013590-pkm81fq1 432 16 structure structure NN cord-013590-pkm81fq1 432 17 of of IN cord-013590-pkm81fq1 432 18 Vδ1 Vδ1 NNP cord-013590-pkm81fq1 432 19 T T NNP cord-013590-pkm81fq1 432 20 cell cell NN cord-013590-pkm81fq1 432 21 receptor receptor NN cord-013590-pkm81fq1 432 22 in in IN cord-013590-pkm81fq1 432 23 complex complex NN cord-013590-pkm81fq1 432 24 with with IN cord-013590-pkm81fq1 432 25 CD1d cd1d NN cord-013590-pkm81fq1 432 26 - - HYPH cord-013590-pkm81fq1 432 27 sulfatide sulfatide NNP cord-013590-pkm81fq1 432 28 shows show VBZ cord-013590-pkm81fq1 432 29 MHC MHC NNP cord-013590-pkm81fq1 432 30 - - HYPH cord-013590-pkm81fq1 432 31 like like JJ cord-013590-pkm81fq1 432 32 recognition recognition NN cord-013590-pkm81fq1 432 33 of of IN cord-013590-pkm81fq1 432 34 a a DT cord-013590-pkm81fq1 432 35 self self NN cord-013590-pkm81fq1 432 36 - - HYPH cord-013590-pkm81fq1 432 37 lipid lipid NN cord-013590-pkm81fq1 432 38 by by IN cord-013590-pkm81fq1 432 39 human human NN cord-013590-pkm81fq1 432 40 γδ γδ IN cord-013590-pkm81fq1 432 41 T t NN cord-013590-pkm81fq1 432 42 cells cell NNS cord-013590-pkm81fq1 432 43 Cutting cut VBG cord-013590-pkm81fq1 432 44 edge edge NN cord-013590-pkm81fq1 432 45 : : : cord-013590-pkm81fq1 432 46 CD1d cd1d NN cord-013590-pkm81fq1 432 47 restriction restriction NN cord-013590-pkm81fq1 432 48 and and CC cord-013590-pkm81fq1 432 49 Th1 th1 NN cord-013590-pkm81fq1 432 50 / / SYM cord-013590-pkm81fq1 432 51 Th2 Th2 NNP cord-013590-pkm81fq1 432 52 / / SYM cord-013590-pkm81fq1 432 53 Th17 th17 CD cord-013590-pkm81fq1 432 54 cytokine cytokine NN cord-013590-pkm81fq1 432 55 secretion secretion NN cord-013590-pkm81fq1 432 56 by by IN cord-013590-pkm81fq1 432 57 human human JJ cord-013590-pkm81fq1 432 58 Vδ3 Vδ3 NNP cord-013590-pkm81fq1 432 59 T T NNP cord-013590-pkm81fq1 432 60 cells cell NNS cord-013590-pkm81fq1 433 1 Qa-1 Qa-1 NNP cord-013590-pkm81fq1 433 2 restricted restrict VBD cord-013590-pkm81fq1 433 3 recognition recognition NN cord-013590-pkm81fq1 433 4 of of IN cord-013590-pkm81fq1 433 5 foreign foreign JJ cord-013590-pkm81fq1 433 6 antigen antigen NN cord-013590-pkm81fq1 433 7 by by IN cord-013590-pkm81fq1 433 8 a a DT cord-013590-pkm81fq1 433 9 γδ γδ NN cord-013590-pkm81fq1 433 10 T t NN cord-013590-pkm81fq1 433 11 - - HYPH cord-013590-pkm81fq1 433 12 cell cell NN cord-013590-pkm81fq1 433 13 hybridoma hybridoma NN cord-013590-pkm81fq1 433 14 Infection infection NN cord-013590-pkm81fq1 433 15 - - HYPH cord-013590-pkm81fq1 433 16 induced induce VBN cord-013590-pkm81fq1 433 17 expansion expansion NN cord-013590-pkm81fq1 433 18 of of IN cord-013590-pkm81fq1 433 19 a a DT cord-013590-pkm81fq1 433 20 MHC MHC NNP cord-013590-pkm81fq1 433 21 class class NN cord-013590-pkm81fq1 433 22 Ib Ib NNP cord-013590-pkm81fq1 433 23 - - HYPH cord-013590-pkm81fq1 433 24 dependent dependent JJ cord-013590-pkm81fq1 433 25 intestinal intestinal JJ cord-013590-pkm81fq1 433 26 intraepithelial intraepithelial NN cord-013590-pkm81fq1 433 27 γδ γδ IN cord-013590-pkm81fq1 433 28 T t NN cord-013590-pkm81fq1 433 29 cell cell NN cord-013590-pkm81fq1 433 30 subset subset VBN cord-013590-pkm81fq1 433 31 A a DT cord-013590-pkm81fq1 433 32 class class NN cord-013590-pkm81fq1 433 33 of of IN cord-013590-pkm81fq1 433 34 γδ γδ NN cord-013590-pkm81fq1 433 35 T t NN cord-013590-pkm81fq1 433 36 cell cell NN cord-013590-pkm81fq1 433 37 receptors receptor NNS cord-013590-pkm81fq1 433 38 recognize recognize VBP cord-013590-pkm81fq1 433 39 the the DT cord-013590-pkm81fq1 433 40 underside underside NN cord-013590-pkm81fq1 433 41 of of IN cord-013590-pkm81fq1 433 42 the the DT cord-013590-pkm81fq1 433 43 antigen antigen NN cord-013590-pkm81fq1 433 44 - - HYPH cord-013590-pkm81fq1 433 45 presenting present VBG cord-013590-pkm81fq1 433 46 molecule molecule NN cord-013590-pkm81fq1 433 47 MR1 MR1 NNP cord-013590-pkm81fq1 433 48 Cell Cell NNP cord-013590-pkm81fq1 433 49 stress stress NN cord-013590-pkm81fq1 433 50 - - HYPH cord-013590-pkm81fq1 433 51 regulated regulate VBN cord-013590-pkm81fq1 433 52 human human JJ cord-013590-pkm81fq1 433 53 major major JJ cord-013590-pkm81fq1 433 54 histocompatibility histocompatibility NN cord-013590-pkm81fq1 433 55 complex complex JJ cord-013590-pkm81fq1 433 56 class class NN cord-013590-pkm81fq1 434 1 I -PRON- PRP cord-013590-pkm81fq1 434 2 gene gene NN cord-013590-pkm81fq1 434 3 expressed express VBN cord-013590-pkm81fq1 434 4 in in IN cord-013590-pkm81fq1 434 5 gastrointestinal gastrointestinal JJ cord-013590-pkm81fq1 434 6 epithelium epithelium NN cord-013590-pkm81fq1 434 7 T T NNP cord-013590-pkm81fq1 434 8 cell cell NN cord-013590-pkm81fq1 434 9 antigen antigen NN cord-013590-pkm81fq1 434 10 receptor receptor NN cord-013590-pkm81fq1 434 11 engagement engagement NN cord-013590-pkm81fq1 434 12 and and CC cord-013590-pkm81fq1 434 13 specificity specificity NN cord-013590-pkm81fq1 434 14 in in IN cord-013590-pkm81fq1 434 15 the the DT cord-013590-pkm81fq1 434 16 recognition recognition NN cord-013590-pkm81fq1 434 17 of of IN cord-013590-pkm81fq1 434 18 stress stress NN cord-013590-pkm81fq1 434 19 - - HYPH cord-013590-pkm81fq1 434 20 inducible inducible JJ cord-013590-pkm81fq1 434 21 MHC MHC NNP cord-013590-pkm81fq1 434 22 class class NN cord-013590-pkm81fq1 434 23 I i NN cord-013590-pkm81fq1 434 24 - - HYPH cord-013590-pkm81fq1 434 25 related relate VBN cord-013590-pkm81fq1 434 26 chains chain NNS cord-013590-pkm81fq1 434 27 by by IN cord-013590-pkm81fq1 434 28 human human JJ cord-013590-pkm81fq1 434 29 epithelial epithelial NN cord-013590-pkm81fq1 434 30 γδ γδ IN cord-013590-pkm81fq1 434 31 T T NNP cord-013590-pkm81fq1 434 32 cells cell NNS cord-013590-pkm81fq1 434 33 Crystal Crystal NNP cord-013590-pkm81fq1 434 34 structure structure NN cord-013590-pkm81fq1 434 35 of of IN cord-013590-pkm81fq1 434 36 a a DT cord-013590-pkm81fq1 434 37 T t NN cord-013590-pkm81fq1 434 38 - - HYPH cord-013590-pkm81fq1 434 39 cell cell NN cord-013590-pkm81fq1 434 40 receptor receptor NN cord-013590-pkm81fq1 434 41 specific specific JJ cord-013590-pkm81fq1 434 42 for for IN cord-013590-pkm81fq1 434 43 the the DT cord-013590-pkm81fq1 434 44 human human JJ cord-013590-pkm81fq1 434 45 MHC MHC NNP cord-013590-pkm81fq1 434 46 class class NN cord-013590-pkm81fq1 434 47 I -PRON- PRP cord-013590-pkm81fq1 434 48 homolog homolog NN cord-013590-pkm81fq1 434 49 MICA MICA NNP cord-013590-pkm81fq1 434 50 Recognition Recognition NNP cord-013590-pkm81fq1 434 51 of of IN cord-013590-pkm81fq1 434 52 the the DT cord-013590-pkm81fq1 434 53 product product NN cord-013590-pkm81fq1 434 54 of of IN cord-013590-pkm81fq1 434 55 a a DT cord-013590-pkm81fq1 434 56 novel novel NN cord-013590-pkm81fq1 434 57 MHC MHC NNP cord-013590-pkm81fq1 434 58 TL TL NNP cord-013590-pkm81fq1 434 59 region region NN cord-013590-pkm81fq1 434 60 gene gene NN cord-013590-pkm81fq1 434 61 ( ( -LRB- cord-013590-pkm81fq1 434 62 27b 27b CD cord-013590-pkm81fq1 434 63 ) ) -RRB- cord-013590-pkm81fq1 434 64 by by IN cord-013590-pkm81fq1 434 65 a a DT cord-013590-pkm81fq1 434 66 mouse mouse NN cord-013590-pkm81fq1 434 67 γδ γδ IN cord-013590-pkm81fq1 434 68 T t NN cord-013590-pkm81fq1 434 69 cell cell NN cord-013590-pkm81fq1 434 70 receptor receptor NN cord-013590-pkm81fq1 435 1 The the DT cord-013590-pkm81fq1 435 2 nature nature NN cord-013590-pkm81fq1 435 3 of of IN cord-013590-pkm81fq1 435 4 major major JJ cord-013590-pkm81fq1 435 5 histocompatibility histocompatibility NN cord-013590-pkm81fq1 435 6 complex complex NN cord-013590-pkm81fq1 435 7 recognition recognition NN cord-013590-pkm81fq1 435 8 by by IN cord-013590-pkm81fq1 435 9 γδ γδ NNP cord-013590-pkm81fq1 435 10 T t NN cord-013590-pkm81fq1 435 11 cells cell NNS cord-013590-pkm81fq1 436 1 A a DT cord-013590-pkm81fq1 436 2 population population NN cord-013590-pkm81fq1 436 3 of of IN cord-013590-pkm81fq1 436 4 murine murine JJ cord-013590-pkm81fq1 436 5 γδ γδ IN cord-013590-pkm81fq1 436 6 T t NN cord-013590-pkm81fq1 436 7 cells cell NNS cord-013590-pkm81fq1 436 8 that that WDT cord-013590-pkm81fq1 436 9 recognize recognize VBP cord-013590-pkm81fq1 436 10 an an DT cord-013590-pkm81fq1 436 11 inducible inducible JJ cord-013590-pkm81fq1 436 12 MHC MHC NNP cord-013590-pkm81fq1 436 13 class class NN cord-013590-pkm81fq1 436 14 Ib Ib NNP cord-013590-pkm81fq1 436 15 molecule molecule NN cord-013590-pkm81fq1 436 16 Crystal Crystal NNP cord-013590-pkm81fq1 436 17 structure structure NN cord-013590-pkm81fq1 436 18 of of IN cord-013590-pkm81fq1 436 19 a a DT cord-013590-pkm81fq1 436 20 γδ γδ NN cord-013590-pkm81fq1 436 21 T t NN cord-013590-pkm81fq1 436 22 cell cell NN cord-013590-pkm81fq1 436 23 receptor receptor NN cord-013590-pkm81fq1 436 24 ligand ligand NN cord-013590-pkm81fq1 436 25 T22 T22 NNP cord-013590-pkm81fq1 436 26 : : : cord-013590-pkm81fq1 436 27 a a DT cord-013590-pkm81fq1 436 28 truncated truncated JJ cord-013590-pkm81fq1 436 29 MHC MHC NNP cord-013590-pkm81fq1 436 30 - - HYPH cord-013590-pkm81fq1 436 31 like like UH cord-013590-pkm81fq1 436 32 fold fold VB cord-013590-pkm81fq1 436 33 Recasting recast VBG cord-013590-pkm81fq1 436 34 human human JJ cord-013590-pkm81fq1 436 35 Vδ1 vδ1 NN cord-013590-pkm81fq1 436 36 lymphocytes lymphocyte NNS cord-013590-pkm81fq1 436 37 in in IN cord-013590-pkm81fq1 436 38 an an DT cord-013590-pkm81fq1 436 39 adaptive adaptive JJ cord-013590-pkm81fq1 436 40 role role NN cord-013590-pkm81fq1 436 41 Vδ2+T vδ2+t NN cord-013590-pkm81fq1 436 42 cells cell NNS cord-013590-pkm81fq1 436 43 -- -- : cord-013590-pkm81fq1 436 44 two two CD cord-013590-pkm81fq1 436 45 subsets subset NNS cord-013590-pkm81fq1 436 46 for for IN cord-013590-pkm81fq1 436 47 the the DT cord-013590-pkm81fq1 436 48 price price NN cord-013590-pkm81fq1 436 49 of of IN cord-013590-pkm81fq1 436 50 one one CD cord-013590-pkm81fq1 436 51 Sensing sensing NN cord-013590-pkm81fq1 436 52 of of IN cord-013590-pkm81fq1 436 53 cell cell NN cord-013590-pkm81fq1 436 54 stress stress NN cord-013590-pkm81fq1 436 55 by by IN cord-013590-pkm81fq1 436 56 human human NN cord-013590-pkm81fq1 436 57 γδ γδ IN cord-013590-pkm81fq1 436 58 TCR TCR NNP cord-013590-pkm81fq1 436 59 - - HYPH cord-013590-pkm81fq1 436 60 dependent dependent JJ cord-013590-pkm81fq1 436 61 recognition recognition NN cord-013590-pkm81fq1 436 62 of of IN cord-013590-pkm81fq1 436 63 annexin annexin NNP cord-013590-pkm81fq1 436 64 A2 A2 NNP cord-013590-pkm81fq1 436 65 γδ γδ CC cord-013590-pkm81fq1 436 66 T T NNP cord-013590-pkm81fq1 436 67 - - HYPH cord-013590-pkm81fq1 436 68 cell cell NN cord-013590-pkm81fq1 436 69 conference conference NN cord-013590-pkm81fq1 436 70 2012 2012 CD cord-013590-pkm81fq1 436 71 : : : cord-013590-pkm81fq1 437 1 Close close JJ cord-013590-pkm81fq1 437 2 encounters encounter NNS cord-013590-pkm81fq1 437 3 for for IN cord-013590-pkm81fq1 437 4 the the DT cord-013590-pkm81fq1 437 5 fifth fifth JJ cord-013590-pkm81fq1 437 6 time time NN cord-013590-pkm81fq1 438 1 Ectopically Ectopically NNP cord-013590-pkm81fq1 438 2 expressed express VBD cord-013590-pkm81fq1 438 3 human human JJ cord-013590-pkm81fq1 438 4 tumor tumor NN cord-013590-pkm81fq1 438 5 biomarker biomarker NN cord-013590-pkm81fq1 438 6 MutS MutS NNP cord-013590-pkm81fq1 438 7 homologue homologue NN cord-013590-pkm81fq1 438 8 2 2 CD cord-013590-pkm81fq1 438 9 is be VBZ cord-013590-pkm81fq1 438 10 a a DT cord-013590-pkm81fq1 438 11 novel novel JJ cord-013590-pkm81fq1 438 12 endogenous endogenous JJ cord-013590-pkm81fq1 438 13 ligand ligand NN cord-013590-pkm81fq1 438 14 that that WDT cord-013590-pkm81fq1 438 15 is be VBZ cord-013590-pkm81fq1 438 16 recognized recognize VBN cord-013590-pkm81fq1 438 17 by by IN cord-013590-pkm81fq1 438 18 human human NN cord-013590-pkm81fq1 438 19 γδ γδ IN cord-013590-pkm81fq1 438 20 T t NN cord-013590-pkm81fq1 438 21 cells cell NNS cord-013590-pkm81fq1 438 22 to to TO cord-013590-pkm81fq1 438 23 induce induce VB cord-013590-pkm81fq1 438 24 innate innate JJ cord-013590-pkm81fq1 438 25 anti anti JJ cord-013590-pkm81fq1 438 26 - - JJ cord-013590-pkm81fq1 438 27 tumor tumor JJ cord-013590-pkm81fq1 438 28 / / SYM cord-013590-pkm81fq1 438 29 virus virus NN cord-013590-pkm81fq1 438 30 immunity immunity NN cord-013590-pkm81fq1 438 31 Antigen Antigen NNP cord-013590-pkm81fq1 438 32 recognition recognition NN cord-013590-pkm81fq1 438 33 properties property NNS cord-013590-pkm81fq1 438 34 of of IN cord-013590-pkm81fq1 438 35 a a DT cord-013590-pkm81fq1 438 36 Vγ1.3Vδ2-T vγ1.3vδ2-t JJ cord-013590-pkm81fq1 438 37 - - HYPH cord-013590-pkm81fq1 438 38 cell cell NN cord-013590-pkm81fq1 438 39 receptor receptor NN cord-013590-pkm81fq1 438 40 from from IN cord-013590-pkm81fq1 438 41 a a DT cord-013590-pkm81fq1 438 42 rare rare JJ cord-013590-pkm81fq1 438 43 variant variant NN cord-013590-pkm81fq1 438 44 of of IN cord-013590-pkm81fq1 438 45 polymyositis polymyositis NNP cord-013590-pkm81fq1 438 46 Target Target NNP cord-013590-pkm81fq1 438 47 specificity specificity NN cord-013590-pkm81fq1 438 48 of of IN cord-013590-pkm81fq1 438 49 an an DT cord-013590-pkm81fq1 438 50 autoreactive autoreactive JJ cord-013590-pkm81fq1 438 51 pathogenic pathogenic JJ cord-013590-pkm81fq1 438 52 human human JJ cord-013590-pkm81fq1 438 53 γδ γδ NN cord-013590-pkm81fq1 438 54 - - HYPH cord-013590-pkm81fq1 438 55 T t NN cord-013590-pkm81fq1 438 56 cell cell NN cord-013590-pkm81fq1 438 57 receptor receptor NN cord-013590-pkm81fq1 438 58 in in IN cord-013590-pkm81fq1 438 59 myositis myositis NN cord-013590-pkm81fq1 438 60 HSV-1 hsv-1 NN cord-013590-pkm81fq1 438 61 glycoprotein glycoprotein VBG cord-013590-pkm81fq1 438 62 I i NN cord-013590-pkm81fq1 438 63 - - HYPH cord-013590-pkm81fq1 438 64 reactive reactive JJ cord-013590-pkm81fq1 438 65 TCR TCR NNP cord-013590-pkm81fq1 438 66 gamma gamma NN cord-013590-pkm81fq1 438 67 delta delta NN cord-013590-pkm81fq1 438 68 cells cell NNS cord-013590-pkm81fq1 438 69 directly directly RB cord-013590-pkm81fq1 438 70 recognize recognize VBP cord-013590-pkm81fq1 438 71 the the DT cord-013590-pkm81fq1 438 72 peptide peptide NN cord-013590-pkm81fq1 438 73 backbone backbone NN cord-013590-pkm81fq1 438 74 in in IN cord-013590-pkm81fq1 438 75 a a DT cord-013590-pkm81fq1 438 76 conformationally conformationally RB cord-013590-pkm81fq1 438 77 dependent dependent JJ cord-013590-pkm81fq1 438 78 manner manner NN cord-013590-pkm81fq1 438 79 Specific specific JJ cord-013590-pkm81fq1 438 80 recognition recognition NN cord-013590-pkm81fq1 438 81 of of IN cord-013590-pkm81fq1 438 82 staphylococcal staphylococcal JJ cord-013590-pkm81fq1 438 83 enterotoxin enterotoxin NNP cord-013590-pkm81fq1 438 84 A A NNP cord-013590-pkm81fq1 438 85 by by IN cord-013590-pkm81fq1 438 86 human human JJ cord-013590-pkm81fq1 438 87 T t NN cord-013590-pkm81fq1 438 88 cells cell NNS cord-013590-pkm81fq1 438 89 bearing bear VBG cord-013590-pkm81fq1 438 90 receptors receptor NNS cord-013590-pkm81fq1 438 91 with with IN cord-013590-pkm81fq1 438 92 the the DT cord-013590-pkm81fq1 438 93 Vγ9 Vγ9 NNP cord-013590-pkm81fq1 438 94 region region NN cord-013590-pkm81fq1 438 95 A a DT cord-013590-pkm81fq1 438 96 novel novel JJ cord-013590-pkm81fq1 438 97 strategy strategy NN cord-013590-pkm81fq1 438 98 to to TO cord-013590-pkm81fq1 438 99 screen screen VB cord-013590-pkm81fq1 438 100 Bacillus Bacillus NNP cord-013590-pkm81fq1 438 101 Calmette Calmette NNP cord-013590-pkm81fq1 438 102 - - HYPH cord-013590-pkm81fq1 438 103 Guérin Guérin NNP cord-013590-pkm81fq1 438 104 protein protein NN cord-013590-pkm81fq1 438 105 antigen antigen NN cord-013590-pkm81fq1 438 106 recognized recognize VBN cord-013590-pkm81fq1 438 107 by by IN cord-013590-pkm81fq1 438 108 γδ γδ NNP cord-013590-pkm81fq1 438 109 TCR TCR NNP cord-013590-pkm81fq1 438 110 Identification Identification NNP cord-013590-pkm81fq1 438 111 of of IN cord-013590-pkm81fq1 438 112 a a DT cord-013590-pkm81fq1 438 113 new new JJ cord-013590-pkm81fq1 438 114 tuberculosis tuberculosis NN cord-013590-pkm81fq1 438 115 antigen antigen NN cord-013590-pkm81fq1 438 116 recognized recognize VBN cord-013590-pkm81fq1 438 117 by by IN cord-013590-pkm81fq1 438 118 γσ γσ NNS cord-013590-pkm81fq1 438 119 T t NN cord-013590-pkm81fq1 438 120 cell cell NN cord-013590-pkm81fq1 438 121 receptor receptor NN cord-013590-pkm81fq1 438 122 γδ γδ IN cord-013590-pkm81fq1 438 123 T t NN cord-013590-pkm81fq1 438 124 cells cell NNS cord-013590-pkm81fq1 438 125 recognize recognize VBP cord-013590-pkm81fq1 438 126 a a DT cord-013590-pkm81fq1 438 127 microbial microbial NN cord-013590-pkm81fq1 438 128 encoded encode VBN cord-013590-pkm81fq1 438 129 B b NN cord-013590-pkm81fq1 438 130 cell cell NN cord-013590-pkm81fq1 438 131 antigen antigen NN cord-013590-pkm81fq1 438 132 to to TO cord-013590-pkm81fq1 438 133 initiate initiate VB cord-013590-pkm81fq1 438 134 a a DT cord-013590-pkm81fq1 438 135 rapid rapid JJ cord-013590-pkm81fq1 438 136 antigen antigen NN cord-013590-pkm81fq1 438 137 - - HYPH cord-013590-pkm81fq1 438 138 specific specific JJ cord-013590-pkm81fq1 438 139 interleukin-17 interleukin-17 NN cord-013590-pkm81fq1 438 140 response response NN cord-013590-pkm81fq1 438 141 Gamma Gamma NNP cord-013590-pkm81fq1 438 142 delta delta NN cord-013590-pkm81fq1 438 143 T t NN cord-013590-pkm81fq1 438 144 cells cell NNS cord-013590-pkm81fq1 438 145 recognize recognize VBP cord-013590-pkm81fq1 438 146 haptens hapten NNS cord-013590-pkm81fq1 438 147 and and CC cord-013590-pkm81fq1 438 148 mount mount VB cord-013590-pkm81fq1 438 149 a a DT cord-013590-pkm81fq1 438 150 haptenspecific haptenspecific NNP cord-013590-pkm81fq1 438 151 response response NN cord-013590-pkm81fq1 439 1 Gamma gamma NN cord-013590-pkm81fq1 439 2 delta delta NN cord-013590-pkm81fq1 439 3 T t NN cord-013590-pkm81fq1 439 4 cell cell NN cord-013590-pkm81fq1 439 5 receptors receptor NNS cord-013590-pkm81fq1 439 6 confer confer VBP cord-013590-pkm81fq1 439 7 autonomous autonomous JJ cord-013590-pkm81fq1 439 8 responsiveness responsiveness NN cord-013590-pkm81fq1 439 9 to to IN cord-013590-pkm81fq1 439 10 the the DT cord-013590-pkm81fq1 439 11 insulin insulin NN cord-013590-pkm81fq1 439 12 - - HYPH cord-013590-pkm81fq1 439 13 peptide peptide NN cord-013590-pkm81fq1 439 14 B:9 B:9 NNP cord-013590-pkm81fq1 439 15 - - HYPH cord-013590-pkm81fq1 439 16 23 23 CD cord-013590-pkm81fq1 439 17 γδ γδ NN cord-013590-pkm81fq1 439 18 T t NN cord-013590-pkm81fq1 439 19 cells cell NNS cord-013590-pkm81fq1 439 20 recognize recognize VBP cord-013590-pkm81fq1 439 21 the the DT cord-013590-pkm81fq1 439 22 insulin insulin NN cord-013590-pkm81fq1 439 23 B:9 B:9 NNP cord-013590-pkm81fq1 439 24 - - HYPH cord-013590-pkm81fq1 439 25 23 23 CD cord-013590-pkm81fq1 439 26 peptide peptide NN cord-013590-pkm81fq1 439 27 antigen antigen NN cord-013590-pkm81fq1 439 28 when when WRB cord-013590-pkm81fq1 439 29 it -PRON- PRP cord-013590-pkm81fq1 439 30 is be VBZ cord-013590-pkm81fq1 439 31 dimerized dimerize VBN cord-013590-pkm81fq1 439 32 through through IN cord-013590-pkm81fq1 439 33 thiol thiol NN cord-013590-pkm81fq1 439 34 oxidation oxidation NN cord-013590-pkm81fq1 439 35 Isolation isolation NN cord-013590-pkm81fq1 439 36 of of IN cord-013590-pkm81fq1 439 37 CD4-CD8-mycobacteria CD4-CD8-mycobacteria NNP cord-013590-pkm81fq1 439 38 - - HYPH cord-013590-pkm81fq1 439 39 reactive reactive JJ cord-013590-pkm81fq1 439 40 T t NN cord-013590-pkm81fq1 439 41 lymphocyte lymphocyte NN cord-013590-pkm81fq1 439 42 clones clone NNS cord-013590-pkm81fq1 439 43 from from IN cord-013590-pkm81fq1 439 44 rheumatoid rheumatoid NN cord-013590-pkm81fq1 439 45 arthritis arthritis NN cord-013590-pkm81fq1 439 46 synovial synovial JJ cord-013590-pkm81fq1 439 47 fluid fluid NNP cord-013590-pkm81fq1 439 48 Recognition Recognition NNP cord-013590-pkm81fq1 439 49 of of IN cord-013590-pkm81fq1 439 50 a a DT cord-013590-pkm81fq1 439 51 peptide peptide JJ cord-013590-pkm81fq1 439 52 antigen antigen NN cord-013590-pkm81fq1 439 53 by by IN cord-013590-pkm81fq1 439 54 heat heat NN cord-013590-pkm81fq1 439 55 shock shock NN cord-013590-pkm81fq1 439 56 - - HYPH cord-013590-pkm81fq1 439 57 reactive reactive JJ cord-013590-pkm81fq1 439 58 γδ γδ NN cord-013590-pkm81fq1 439 59 T t NN cord-013590-pkm81fq1 439 60 lymphocytes lymphocyte NNS cord-013590-pkm81fq1 439 61 Heat heat VB cord-013590-pkm81fq1 439 62 shock shock NN cord-013590-pkm81fq1 439 63 protein protein NN cord-013590-pkm81fq1 440 1 Hsp60-reactive Hsp60-reactive NNP cord-013590-pkm81fq1 441 1 γδ γδ CC cord-013590-pkm81fq1 441 2 cells cell NNS cord-013590-pkm81fq1 441 3 : : : cord-013590-pkm81fq1 441 4 a a DT cord-013590-pkm81fq1 441 5 large large JJ cord-013590-pkm81fq1 441 6 , , , cord-013590-pkm81fq1 441 7 diversified diversified JJ cord-013590-pkm81fq1 441 8 T t NN cord-013590-pkm81fq1 441 9 - - HYPH cord-013590-pkm81fq1 441 10 lymphocyte lymphocyte NN cord-013590-pkm81fq1 441 11 subset subset VBN cord-013590-pkm81fq1 441 12 with with IN cord-013590-pkm81fq1 441 13 highly highly RB cord-013590-pkm81fq1 441 14 focused focused JJ cord-013590-pkm81fq1 441 15 specificity specificity NN cord-013590-pkm81fq1 441 16 Human Human NNP cord-013590-pkm81fq1 441 17 T t NN cord-013590-pkm81fq1 441 18 - - HYPH cord-013590-pkm81fq1 441 19 cell cell NN cord-013590-pkm81fq1 441 20 recognition recognition NN cord-013590-pkm81fq1 441 21 of of IN cord-013590-pkm81fq1 441 22 Listeria Listeria NNP cord-013590-pkm81fq1 441 23 monocytogenes monocytogene NNS cord-013590-pkm81fq1 441 24 : : : cord-013590-pkm81fq1 441 25 recognition recognition NN cord-013590-pkm81fq1 441 26 of of IN cord-013590-pkm81fq1 441 27 listeriolysin listeriolysin NNP cord-013590-pkm81fq1 441 28 O O NNP cord-013590-pkm81fq1 441 29 by by IN cord-013590-pkm81fq1 441 30 TcRαβ+ tcrαβ+ NN cord-013590-pkm81fq1 441 31 and and CC cord-013590-pkm81fq1 441 32 TcRγδ+ TcRγδ+ NNP cord-013590-pkm81fq1 441 33 T T NNP cord-013590-pkm81fq1 441 34 cells cell NNS cord-013590-pkm81fq1 442 1 Human Human NNP cord-013590-pkm81fq1 442 2 TCR TCR NNP cord-013590-pkm81fq1 442 3 - - HYPH cord-013590-pkm81fq1 442 4 γ+/δ+ γ+/δ+ NNP cord-013590-pkm81fq1 443 1 , , , cord-013590-pkm81fq1 443 2 CD8 CD8 NNP cord-013590-pkm81fq1 443 3 + + CC cord-013590-pkm81fq1 443 4 T T NNP cord-013590-pkm81fq1 443 5 lymphocytes lymphocyte NNS cord-013590-pkm81fq1 443 6 recognize recognize VBP cord-013590-pkm81fq1 443 7 tetanus tetanus NN cord-013590-pkm81fq1 443 8 toxoid toxoid NN cord-013590-pkm81fq1 443 9 in in IN cord-013590-pkm81fq1 443 10 an an DT cord-013590-pkm81fq1 443 11 MHC MHC NNP cord-013590-pkm81fq1 443 12 - - HYPH cord-013590-pkm81fq1 443 13 restricted restrict VBN cord-013590-pkm81fq1 443 14 fashion fashion NN cord-013590-pkm81fq1 443 15 Dual dual JJ cord-013590-pkm81fq1 443 16 antigenic antigenic JJ cord-013590-pkm81fq1 443 17 recognition recognition NN cord-013590-pkm81fq1 443 18 by by IN cord-013590-pkm81fq1 443 19 cloned clone VBN cord-013590-pkm81fq1 443 20 human human NN cord-013590-pkm81fq1 443 21 γδ γδ IN cord-013590-pkm81fq1 443 22 T t NN cord-013590-pkm81fq1 443 23 cells cell NNS cord-013590-pkm81fq1 444 1 Cytotoxic Cytotoxic NNP cord-013590-pkm81fq1 444 2 T t NN cord-013590-pkm81fq1 444 3 lymphocytes lymphocyte NNS cord-013590-pkm81fq1 444 4 specific specific JJ cord-013590-pkm81fq1 444 5 for for IN cord-013590-pkm81fq1 444 6 self self NN cord-013590-pkm81fq1 444 7 tumor tumor NN cord-013590-pkm81fq1 444 8 immunoglobulin immunoglobulin NN cord-013590-pkm81fq1 444 9 express express VBP cord-013590-pkm81fq1 444 10 T T NNP cord-013590-pkm81fq1 444 11 cell cell NN cord-013590-pkm81fq1 444 12 receptor receptor NN cord-013590-pkm81fq1 444 13 δ δ NN cord-013590-pkm81fq1 444 14 chain chain NN cord-013590-pkm81fq1 444 15 Gamma Gamma NNP cord-013590-pkm81fq1 444 16 delta delta NN cord-013590-pkm81fq1 444 17 T T NNP cord-013590-pkm81fq1 444 18 cell cell NN cord-013590-pkm81fq1 444 19 recognition recognition NN cord-013590-pkm81fq1 444 20 of of IN cord-013590-pkm81fq1 444 21 tumor tumor NN cord-013590-pkm81fq1 444 22 Ig Ig NNP cord-013590-pkm81fq1 444 23 peptide peptide JJ cord-013590-pkm81fq1 444 24 Recognition recognition NN cord-013590-pkm81fq1 444 25 of of IN cord-013590-pkm81fq1 444 26 synthetic synthetic JJ cord-013590-pkm81fq1 444 27 polyanionic polyanionic JJ cord-013590-pkm81fq1 444 28 ligands ligand NNS cord-013590-pkm81fq1 444 29 underlies underlie VBZ cord-013590-pkm81fq1 444 30 " " `` cord-013590-pkm81fq1 444 31 spontaneous spontaneous JJ cord-013590-pkm81fq1 444 32 " " '' cord-013590-pkm81fq1 444 33 reactivity reactivity NN cord-013590-pkm81fq1 444 34 of of IN cord-013590-pkm81fq1 444 35 Vγ1 vγ1 NN cord-013590-pkm81fq1 444 36 γδTCRs γδTCRs NNP cord-013590-pkm81fq1 444 37 CDR3 CDR3 NNP cord-013590-pkm81fq1 444 38 length length NN cord-013590-pkm81fq1 444 39 in in IN cord-013590-pkm81fq1 444 40 antigen antigen NN cord-013590-pkm81fq1 444 41 - - HYPH cord-013590-pkm81fq1 444 42 specific specific JJ cord-013590-pkm81fq1 444 43 immune immune JJ cord-013590-pkm81fq1 444 44 receptors receptor NNS cord-013590-pkm81fq1 444 45 Cells cell NNS cord-013590-pkm81fq1 444 46 : : : cord-013590-pkm81fq1 445 1 T t NN cord-013590-pkm81fq1 445 2 cells cell NNS cord-013590-pkm81fq1 445 3 with with IN cord-013590-pkm81fq1 445 4 B b NN cord-013590-pkm81fq1 445 5 - - HYPH cord-013590-pkm81fq1 445 6 cell cell NN cord-013590-pkm81fq1 445 7 - - HYPH cord-013590-pkm81fq1 445 8 like like JJ cord-013590-pkm81fq1 445 9 recognition recognition NN cord-013590-pkm81fq1 445 10 properties property NNS cord-013590-pkm81fq1 445 11 γδ γδ IN cord-013590-pkm81fq1 445 12 T T NNP cord-013590-pkm81fq1 445 13 cells cell NNS cord-013590-pkm81fq1 445 14 : : : cord-013590-pkm81fq1 445 15 first first JJ cord-013590-pkm81fq1 445 16 line line NN cord-013590-pkm81fq1 445 17 of of IN cord-013590-pkm81fq1 445 18 defense defense NN cord-013590-pkm81fq1 445 19 and and CC cord-013590-pkm81fq1 445 20 beyond beyond IN cord-013590-pkm81fq1 445 21 Restricted restricted JJ cord-013590-pkm81fq1 445 22 diversity diversity NN cord-013590-pkm81fq1 445 23 of of IN cord-013590-pkm81fq1 445 24 Vγ9-JP Vγ9-JP NNP cord-013590-pkm81fq1 445 25 rearrangements rearrangement NNS cord-013590-pkm81fq1 445 26 in in IN cord-013590-pkm81fq1 445 27 unstimulated unstimulated JJ cord-013590-pkm81fq1 445 28 human human JJ cord-013590-pkm81fq1 445 29 γ/ γ/ NNP cord-013590-pkm81fq1 446 1 δ δ NNP cord-013590-pkm81fq1 446 2 T T NNP cord-013590-pkm81fq1 446 3 lymphocytes lymphocyte VBZ cord-013590-pkm81fq1 446 4 Evolution evolution NN cord-013590-pkm81fq1 446 5 of of IN cord-013590-pkm81fq1 446 6 the the DT cord-013590-pkm81fq1 446 7 V v NN cord-013590-pkm81fq1 446 8 , , , cord-013590-pkm81fq1 446 9 D D NNP cord-013590-pkm81fq1 446 10 , , , cord-013590-pkm81fq1 446 11 and and CC cord-013590-pkm81fq1 446 12 J J NNP cord-013590-pkm81fq1 446 13 gene gene NN cord-013590-pkm81fq1 446 14 segments segment NNS cord-013590-pkm81fq1 446 15 used use VBN cord-013590-pkm81fq1 446 16 in in IN cord-013590-pkm81fq1 446 17 the the DT cord-013590-pkm81fq1 446 18 primate primate JJ cord-013590-pkm81fq1 446 19 T t NN cord-013590-pkm81fq1 446 20 - - HYPH cord-013590-pkm81fq1 446 21 cell cell NN cord-013590-pkm81fq1 446 22 receptor receptor NN cord-013590-pkm81fq1 447 1 reveals reveal VBZ cord-013590-pkm81fq1 447 2 a a DT cord-013590-pkm81fq1 447 3 dichotomy dichotomy NN cord-013590-pkm81fq1 447 4 of of IN cord-013590-pkm81fq1 447 5 conservation conservation NN cord-013590-pkm81fq1 447 6 and and CC cord-013590-pkm81fq1 447 7 diversity diversity NN cord-013590-pkm81fq1 447 8 Conservation Conservation NNP cord-013590-pkm81fq1 447 9 of of IN cord-013590-pkm81fq1 447 10 nonpeptide nonpeptide JJ cord-013590-pkm81fq1 447 11 antigen antigen NN cord-013590-pkm81fq1 447 12 recognition recognition NN cord-013590-pkm81fq1 447 13 by by IN cord-013590-pkm81fq1 447 14 Rhesus Rhesus NNP cord-013590-pkm81fq1 447 15 monkey monkey NN cord-013590-pkm81fq1 447 16 Vγ2Vδ2 vγ2vδ2 NN cord-013590-pkm81fq1 447 17 T T NNP cord-013590-pkm81fq1 447 18 cells cell NNS cord-013590-pkm81fq1 447 19 Vγ9 Vγ9 NNS cord-013590-pkm81fq1 447 20 and and CC cord-013590-pkm81fq1 447 21 Vδ2 Vδ2 VBD cord-013590-pkm81fq1 447 22 T T NNP cord-013590-pkm81fq1 447 23 cell cell NN cord-013590-pkm81fq1 447 24 antigen antigen NN cord-013590-pkm81fq1 447 25 receptor receptor NN cord-013590-pkm81fq1 447 26 genes gene NNS cord-013590-pkm81fq1 447 27 and and CC cord-013590-pkm81fq1 447 28 butyrophilin butyrophilin NN cord-013590-pkm81fq1 447 29 3 3 CD cord-013590-pkm81fq1 447 30 ( ( -LRB- cord-013590-pkm81fq1 447 31 BTN3 BTN3 NNP cord-013590-pkm81fq1 447 32 ) ) -RRB- cord-013590-pkm81fq1 447 33 emerged emerge VBD cord-013590-pkm81fq1 447 34 with with IN cord-013590-pkm81fq1 447 35 placental placental JJ cord-013590-pkm81fq1 447 36 mammals mammal NNS cord-013590-pkm81fq1 447 37 and and CC cord-013590-pkm81fq1 447 38 are be VBP cord-013590-pkm81fq1 447 39 concomitantly concomitantly RB cord-013590-pkm81fq1 447 40 preserved preserve VBN cord-013590-pkm81fq1 447 41 in in IN cord-013590-pkm81fq1 447 42 selected select VBN cord-013590-pkm81fq1 447 43 species specie NNS cord-013590-pkm81fq1 447 44 like like IN cord-013590-pkm81fq1 447 45 alpaca alpaca NN cord-013590-pkm81fq1 447 46 ( ( -LRB- cord-013590-pkm81fq1 447 47 Vicugna Vicugna NNP cord-013590-pkm81fq1 447 48 pacos pacos NNP cord-013590-pkm81fq1 447 49 ) ) -RRB- cord-013590-pkm81fq1 448 1 Alpaca Alpaca NNP cord-013590-pkm81fq1 448 2 ( ( -LRB- cord-013590-pkm81fq1 448 3 Vicugna Vicugna NNP cord-013590-pkm81fq1 448 4 pacos pacos NNP cord-013590-pkm81fq1 448 5 ) ) -RRB- cord-013590-pkm81fq1 448 6 , , , cord-013590-pkm81fq1 448 7 the the DT cord-013590-pkm81fq1 448 8 first first JJ cord-013590-pkm81fq1 448 9 nonprimate nonprimate NN cord-013590-pkm81fq1 448 10 species specie NNS cord-013590-pkm81fq1 448 11 with with IN cord-013590-pkm81fq1 448 12 a a DT cord-013590-pkm81fq1 448 13 phosphoantigen phosphoantigen NN cord-013590-pkm81fq1 448 14 - - HYPH cord-013590-pkm81fq1 448 15 reactive reactive JJ cord-013590-pkm81fq1 448 16 Vγ9Vδ2 Vγ9Vδ2 NNS cord-013590-pkm81fq1 448 17 T t NN cord-013590-pkm81fq1 448 18 cell cell NN cord-013590-pkm81fq1 448 19 subset subset VBN cord-013590-pkm81fq1 448 20 Nonpeptide Nonpeptide NNP cord-013590-pkm81fq1 448 21 antigens antigen NNS cord-013590-pkm81fq1 448 22 , , , cord-013590-pkm81fq1 448 23 presentation presentation NN cord-013590-pkm81fq1 448 24 mechanisms mechanism NNS cord-013590-pkm81fq1 448 25 , , , cord-013590-pkm81fq1 448 26 and and CC cord-013590-pkm81fq1 448 27 immunological immunological JJ cord-013590-pkm81fq1 448 28 memory memory NN cord-013590-pkm81fq1 448 29 of of IN cord-013590-pkm81fq1 448 30 human human NN cord-013590-pkm81fq1 448 31 Vγ2Vδ2 Vγ2Vδ2 NNP cord-013590-pkm81fq1 448 32 T T NNP cord-013590-pkm81fq1 448 33 cells cell NNS cord-013590-pkm81fq1 448 34 : : : cord-013590-pkm81fq1 448 35 discriminating discriminate VBG cord-013590-pkm81fq1 448 36 friend friend NN cord-013590-pkm81fq1 448 37 from from IN cord-013590-pkm81fq1 448 38 foe foe NN cord-013590-pkm81fq1 448 39 through through IN cord-013590-pkm81fq1 448 40 the the DT cord-013590-pkm81fq1 448 41 recognition recognition NN cord-013590-pkm81fq1 448 42 of of IN cord-013590-pkm81fq1 448 43 prenyl prenyl NNP cord-013590-pkm81fq1 448 44 pyrophosphate pyrophosphate NN cord-013590-pkm81fq1 448 45 antigens antigen NNS cord-013590-pkm81fq1 448 46 Early early RB cord-013590-pkm81fq1 448 47 innate innate JJ cord-013590-pkm81fq1 448 48 responses response NNS cord-013590-pkm81fq1 448 49 to to IN cord-013590-pkm81fq1 448 50 pathogens pathogen NNS cord-013590-pkm81fq1 448 51 : : : cord-013590-pkm81fq1 449 1 pattern pattern NN cord-013590-pkm81fq1 449 2 recognition recognition NN cord-013590-pkm81fq1 449 3 by by IN cord-013590-pkm81fq1 449 4 unconventional unconventional JJ cord-013590-pkm81fq1 449 5 human human JJ cord-013590-pkm81fq1 449 6 T T NNP cord-013590-pkm81fq1 449 7 - - HYPH cord-013590-pkm81fq1 449 8 cells cell NNS cord-013590-pkm81fq1 449 9 Human Human NNP cord-013590-pkm81fq1 449 10 T t NN cord-013590-pkm81fq1 449 11 cell cell NN cord-013590-pkm81fq1 449 12 receptor receptor NN cord-013590-pkm81fq1 449 13 γδ γδ IN cord-013590-pkm81fq1 449 14 cells cell NNS cord-013590-pkm81fq1 449 15 recognize recognize VBP cord-013590-pkm81fq1 449 16 endogenous endogenous JJ cord-013590-pkm81fq1 449 17 mevalonate mevalonate NN cord-013590-pkm81fq1 449 18 metabolites metabolite NNS cord-013590-pkm81fq1 449 19 in in IN cord-013590-pkm81fq1 449 20 tumor tumor NN cord-013590-pkm81fq1 449 21 cells cell NNS cord-013590-pkm81fq1 450 1 Alkylamines Alkylamines NNPS cord-013590-pkm81fq1 450 2 cause cause VBP cord-013590-pkm81fq1 451 1 Vγ9Vδ2 Vγ9Vδ2 NNP cord-013590-pkm81fq1 451 2 T T NNP cord-013590-pkm81fq1 451 3 - - HYPH cord-013590-pkm81fq1 451 4 cell cell NN cord-013590-pkm81fq1 451 5 activation activation NN cord-013590-pkm81fq1 451 6 and and CC cord-013590-pkm81fq1 451 7 proliferation proliferation NN cord-013590-pkm81fq1 451 8 by by IN cord-013590-pkm81fq1 451 9 inhibiting inhibit VBG cord-013590-pkm81fq1 451 10 the the DT cord-013590-pkm81fq1 451 11 mevalonate mevalonate NNP cord-013590-pkm81fq1 451 12 pathway pathway NN cord-013590-pkm81fq1 452 1 The the DT cord-013590-pkm81fq1 452 2 promise promise NN cord-013590-pkm81fq1 452 3 of of IN cord-013590-pkm81fq1 452 4 γδ γδ NNP cord-013590-pkm81fq1 452 5 T T NNP cord-013590-pkm81fq1 452 6 cells cell NNS cord-013590-pkm81fq1 452 7 and and CC cord-013590-pkm81fq1 452 8 the the DT cord-013590-pkm81fq1 452 9 γδ γδ NN cord-013590-pkm81fq1 452 10 T T NNP cord-013590-pkm81fq1 452 11 cell cell NN cord-013590-pkm81fq1 452 12 receptor receptor NN cord-013590-pkm81fq1 452 13 for for IN cord-013590-pkm81fq1 452 14 cancer cancer NN cord-013590-pkm81fq1 452 15 immunotherapy immunotherapy NN cord-013590-pkm81fq1 452 16 Human Human NNP cord-013590-pkm81fq1 452 17 γδ γδ IN cord-013590-pkm81fq1 452 18 TCR TCR NNP cord-013590-pkm81fq1 452 19 repertoires repertoire NNS cord-013590-pkm81fq1 452 20 in in IN cord-013590-pkm81fq1 452 21 health health NN cord-013590-pkm81fq1 452 22 and and CC cord-013590-pkm81fq1 452 23 disease disease NN cord-013590-pkm81fq1 452 24 Direct direct JJ cord-013590-pkm81fq1 452 25 presentation presentation NN cord-013590-pkm81fq1 452 26 of of IN cord-013590-pkm81fq1 452 27 nonpeptide nonpeptide NNP cord-013590-pkm81fq1 452 28 prenyl prenyl NNP cord-013590-pkm81fq1 452 29 pryophosphate pryophosphate NNP cord-013590-pkm81fq1 452 30 antigens antigen NNS cord-013590-pkm81fq1 452 31 to to IN cord-013590-pkm81fq1 452 32 human human JJ cord-013590-pkm81fq1 452 33 gamma gamma NN cord-013590-pkm81fq1 452 34 delta delta NN cord-013590-pkm81fq1 452 35 T T NNP cord-013590-pkm81fq1 452 36 cells cell NNS cord-013590-pkm81fq1 453 1 Key key JJ cord-013590-pkm81fq1 453 2 implication implication NN cord-013590-pkm81fq1 453 3 of of IN cord-013590-pkm81fq1 453 4 CD277 cd277 NN cord-013590-pkm81fq1 453 5 / / SYM cord-013590-pkm81fq1 453 6 Butyrophilin-3 Butyrophilin-3 NNP cord-013590-pkm81fq1 453 7 ( ( -LRB- cord-013590-pkm81fq1 453 8 BTN3A BTN3A NNP cord-013590-pkm81fq1 453 9 ) ) -RRB- cord-013590-pkm81fq1 453 10 in in IN cord-013590-pkm81fq1 453 11 cellular cellular JJ cord-013590-pkm81fq1 453 12 stress stress NN cord-013590-pkm81fq1 453 13 sensing sensing NN cord-013590-pkm81fq1 453 14 by by IN cord-013590-pkm81fq1 453 15 a a DT cord-013590-pkm81fq1 453 16 major major JJ cord-013590-pkm81fq1 453 17 human human NN cord-013590-pkm81fq1 453 18 γ γ NN cord-013590-pkm81fq1 453 19 δ δ NN cord-013590-pkm81fq1 453 20 T T NNP cord-013590-pkm81fq1 453 21 cell cell NN cord-013590-pkm81fq1 453 22 subset subset VBN cord-013590-pkm81fq1 453 23 The the DT cord-013590-pkm81fq1 453 24 molecular molecular JJ cord-013590-pkm81fq1 453 25 basis basis NN cord-013590-pkm81fq1 453 26 for for IN cord-013590-pkm81fq1 453 27 modulation modulation NN cord-013590-pkm81fq1 453 28 of of IN cord-013590-pkm81fq1 453 29 human human JJ cord-013590-pkm81fq1 453 30 Vγ9Vδ2 Vγ9Vδ2 NNS cord-013590-pkm81fq1 453 31 T T NNP cord-013590-pkm81fq1 453 32 cell cell NN cord-013590-pkm81fq1 453 33 responses response NNS cord-013590-pkm81fq1 453 34 by by IN cord-013590-pkm81fq1 453 35 CD277 cd277 NN cord-013590-pkm81fq1 453 36 / / SYM cord-013590-pkm81fq1 453 37 butyrophilin-3 butyrophilin-3 NN cord-013590-pkm81fq1 453 38 ( ( -LRB- cord-013590-pkm81fq1 453 39 BTN3A)-specific btn3a)-specific JJ cord-013590-pkm81fq1 453 40 antibodies antibody NNS cord-013590-pkm81fq1 453 41 Regulation regulation NN cord-013590-pkm81fq1 453 42 of of IN cord-013590-pkm81fq1 453 43 immunity immunity NN cord-013590-pkm81fq1 453 44 by by IN cord-013590-pkm81fq1 453 45 butyrophilins butyrophilins NNP cord-013590-pkm81fq1 454 1 Butyrophilin Butyrophilin NNP cord-013590-pkm81fq1 454 2 3A1 3a1 CD cord-013590-pkm81fq1 454 3 binds bind VBZ cord-013590-pkm81fq1 454 4 phosphorylated phosphorylated JJ cord-013590-pkm81fq1 454 5 antigens antigen NNS cord-013590-pkm81fq1 454 6 and and CC cord-013590-pkm81fq1 454 7 stimulates stimulate VBZ cord-013590-pkm81fq1 454 8 human human NN cord-013590-pkm81fq1 454 9 γδ γδ IN cord-013590-pkm81fq1 454 10 T t NN cord-013590-pkm81fq1 454 11 cells cell NNS cord-013590-pkm81fq1 455 1 The the DT cord-013590-pkm81fq1 455 2 intracellular intracellular JJ cord-013590-pkm81fq1 455 3 B30.2 B30.2 NNP cord-013590-pkm81fq1 455 4 domain domain NN cord-013590-pkm81fq1 455 5 of of IN cord-013590-pkm81fq1 455 6 butyrophilin butyrophilin NNP cord-013590-pkm81fq1 455 7 3A1 3A1 NNP cord-013590-pkm81fq1 455 8 binds bind VBZ cord-013590-pkm81fq1 455 9 phosphoantigens phosphoantigen NNS cord-013590-pkm81fq1 455 10 to to TO cord-013590-pkm81fq1 455 11 mediate mediate VB cord-013590-pkm81fq1 455 12 activation activation NN cord-013590-pkm81fq1 455 13 of of IN cord-013590-pkm81fq1 455 14 human human JJ cord-013590-pkm81fq1 455 15 Vγ9Vδ2 Vγ9Vδ2 NNS cord-013590-pkm81fq1 455 16 T T NNP cord-013590-pkm81fq1 455 17 Cells Cells NNP cord-013590-pkm81fq1 455 18 Sensor Sensor NNP cord-013590-pkm81fq1 455 19 function function NN cord-013590-pkm81fq1 455 20 for for IN cord-013590-pkm81fq1 455 21 butyrophilin butyrophilin NNP cord-013590-pkm81fq1 455 22 3A1 3a1 CD cord-013590-pkm81fq1 455 23 in in IN cord-013590-pkm81fq1 455 24 prenyl prenyl NNP cord-013590-pkm81fq1 455 25 pyrophosphate pyrophosphate NN cord-013590-pkm81fq1 455 26 stimulation stimulation NN cord-013590-pkm81fq1 455 27 of of IN cord-013590-pkm81fq1 455 28 human human JJ cord-013590-pkm81fq1 455 29 Vγ2Vδ2 Vγ2Vδ2 NNP cord-013590-pkm81fq1 455 30 T T NNP cord-013590-pkm81fq1 455 31 cells cell NNS cord-013590-pkm81fq1 456 1 The the DT cord-013590-pkm81fq1 456 2 butyrophilin butyrophilin NN cord-013590-pkm81fq1 456 3 3A1 3a1 CD cord-013590-pkm81fq1 456 4 intracellular intracellular JJ cord-013590-pkm81fq1 456 5 domain domain NN cord-013590-pkm81fq1 456 6 undergoes undergo VBZ cord-013590-pkm81fq1 456 7 a a DT cord-013590-pkm81fq1 456 8 conformational conformational JJ cord-013590-pkm81fq1 456 9 change change NN cord-013590-pkm81fq1 456 10 involving involve VBG cord-013590-pkm81fq1 456 11 the the DT cord-013590-pkm81fq1 456 12 juxtamembrane juxtamembrane NNP cord-013590-pkm81fq1 456 13 region region NN cord-013590-pkm81fq1 456 14 Phosphoantigen Phosphoantigen NNP cord-013590-pkm81fq1 456 15 - - HYPH cord-013590-pkm81fq1 456 16 induced induce VBN cord-013590-pkm81fq1 456 17 conformational conformational JJ cord-013590-pkm81fq1 456 18 change change NN cord-013590-pkm81fq1 456 19 of of IN cord-013590-pkm81fq1 456 20 butyrophilin butyrophilin NNP cord-013590-pkm81fq1 456 21 3A1 3a1 CD cord-013590-pkm81fq1 456 22 ( ( -LRB- cord-013590-pkm81fq1 456 23 BTN3A1 BTN3A1 NNP cord-013590-pkm81fq1 456 24 ) ) -RRB- cord-013590-pkm81fq1 456 25 and and CC cord-013590-pkm81fq1 456 26 its -PRON- PRP$ cord-013590-pkm81fq1 456 27 implication implication NN cord-013590-pkm81fq1 456 28 on on IN cord-013590-pkm81fq1 456 29 Vγ9Vδ2 Vγ9Vδ2 NNS cord-013590-pkm81fq1 456 30 T T NNP cord-013590-pkm81fq1 456 31 cell cell NN cord-013590-pkm81fq1 456 32 activation activation NN cord-013590-pkm81fq1 457 1 The the DT cord-013590-pkm81fq1 457 2 juxtamembrane juxtamembrane NNP cord-013590-pkm81fq1 457 3 domain domain NN cord-013590-pkm81fq1 457 4 of of IN cord-013590-pkm81fq1 457 5 butyrophilin butyrophilin NNP cord-013590-pkm81fq1 458 1 BTN3A1 BTN3A1 NNP cord-013590-pkm81fq1 458 2 controls control VBZ cord-013590-pkm81fq1 458 3 phosphoantigen phosphoantigen NN cord-013590-pkm81fq1 458 4 - - HYPH cord-013590-pkm81fq1 458 5 mediated mediate VBN cord-013590-pkm81fq1 458 6 activation activation NN cord-013590-pkm81fq1 458 7 of of IN cord-013590-pkm81fq1 458 8 human human JJ cord-013590-pkm81fq1 458 9 Vγ9Vδ2 Vγ9Vδ2 NNS cord-013590-pkm81fq1 458 10 T T NNP cord-013590-pkm81fq1 458 11 cells cell NNS cord-013590-pkm81fq1 458 12 Activation Activation NNP cord-013590-pkm81fq1 458 13 of of IN cord-013590-pkm81fq1 458 14 human human NN cord-013590-pkm81fq1 458 15 γδ γδ IN cord-013590-pkm81fq1 458 16 T t NN cord-013590-pkm81fq1 458 17 cells cell NNS cord-013590-pkm81fq1 458 18 by by IN cord-013590-pkm81fq1 458 19 cytosolic cytosolic JJ cord-013590-pkm81fq1 458 20 interactions interaction NNS cord-013590-pkm81fq1 458 21 of of IN cord-013590-pkm81fq1 458 22 BTN3A1 BTN3A1 NNP cord-013590-pkm81fq1 458 23 with with IN cord-013590-pkm81fq1 458 24 soluble soluble JJ cord-013590-pkm81fq1 458 25 phosphoantigens phosphoantigen NNS cord-013590-pkm81fq1 458 26 and and CC cord-013590-pkm81fq1 458 27 the the DT cord-013590-pkm81fq1 458 28 cytoskeletal cytoskeletal JJ cord-013590-pkm81fq1 458 29 adaptor adaptor NN cord-013590-pkm81fq1 458 30 periplakin periplakin NNP cord-013590-pkm81fq1 459 1 RhoB RhoB NNP cord-013590-pkm81fq1 459 2 mediates mediate VBZ cord-013590-pkm81fq1 459 3 phosphoantigen phosphoantigen NNP cord-013590-pkm81fq1 459 4 recognition recognition NN cord-013590-pkm81fq1 459 5 by by IN cord-013590-pkm81fq1 459 6 Vγ9Vδ2 Vγ9Vδ2 NNS cord-013590-pkm81fq1 459 7 T T NNP cord-013590-pkm81fq1 459 8 cell cell NN cord-013590-pkm81fq1 459 9 receptor receptor NN cord-013590-pkm81fq1 459 10 Heteromeric Heteromeric NNP cord-013590-pkm81fq1 459 11 interactions interaction NNS cord-013590-pkm81fq1 460 1 regulate regulate VB cord-013590-pkm81fq1 460 2 butyrophilin butyrophilin NNP cord-013590-pkm81fq1 460 3 ( ( -LRB- cord-013590-pkm81fq1 460 4 BTN BTN NNP cord-013590-pkm81fq1 460 5 ) ) -RRB- cord-013590-pkm81fq1 460 6 and and CC cord-013590-pkm81fq1 460 7 BTN BTN NNP cord-013590-pkm81fq1 460 8 - - HYPH cord-013590-pkm81fq1 460 9 like like JJ cord-013590-pkm81fq1 460 10 molecules molecule NNS cord-013590-pkm81fq1 460 11 governing govern VBG cord-013590-pkm81fq1 460 12 γδ γδ CC cord-013590-pkm81fq1 460 13 T t NN cord-013590-pkm81fq1 460 14 cell cell NN cord-013590-pkm81fq1 460 15 biology biology NN cord-013590-pkm81fq1 461 1 Vγ9Vδ2 Vγ9Vδ2 NNP cord-013590-pkm81fq1 461 2 TCR TCR NNP cord-013590-pkm81fq1 461 3 - - HYPH cord-013590-pkm81fq1 461 4 activation activation NN cord-013590-pkm81fq1 461 5 by by IN cord-013590-pkm81fq1 461 6 phosphorylated phosphorylated JJ cord-013590-pkm81fq1 461 7 antigens antigen NNS cord-013590-pkm81fq1 461 8 requires require VBZ cord-013590-pkm81fq1 461 9 butyrophilin butyrophilin NN cord-013590-pkm81fq1 461 10 3 3 CD cord-013590-pkm81fq1 461 11 A1 A1 NNP cord-013590-pkm81fq1 461 12 ( ( -LRB- cord-013590-pkm81fq1 461 13 BTN3A1 BTN3A1 NNP cord-013590-pkm81fq1 461 14 ) ) -RRB- cord-013590-pkm81fq1 461 15 and and CC cord-013590-pkm81fq1 461 16 additional additional JJ cord-013590-pkm81fq1 461 17 genes gene NNS cord-013590-pkm81fq1 461 18 on on IN cord-013590-pkm81fq1 461 19 human human JJ cord-013590-pkm81fq1 461 20 chromosome chromosome NN cord-013590-pkm81fq1 461 21 6 6 CD cord-013590-pkm81fq1 461 22 Butyrophilin Butyrophilin NNP cord-013590-pkm81fq1 461 23 2A1 2A1 NNP cord-013590-pkm81fq1 461 24 is be VBZ cord-013590-pkm81fq1 461 25 essential essential JJ cord-013590-pkm81fq1 461 26 for for IN cord-013590-pkm81fq1 461 27 phosphoantigen phosphoantigen NN cord-013590-pkm81fq1 461 28 reactivity reactivity NN cord-013590-pkm81fq1 461 29 by by IN cord-013590-pkm81fq1 461 30 gd gd NNP cord-013590-pkm81fq1 461 31 T T NNP cord-013590-pkm81fq1 461 32 cells cell NNS cord-013590-pkm81fq1 462 1 Butyrophilin-2A1 Butyrophilin-2A1 NNP cord-013590-pkm81fq1 462 2 directly directly RB cord-013590-pkm81fq1 462 3 binds bind VBZ cord-013590-pkm81fq1 462 4 germline germline NN cord-013590-pkm81fq1 462 5 - - HYPH cord-013590-pkm81fq1 462 6 encoded encode VBN cord-013590-pkm81fq1 462 7 regions region NNS cord-013590-pkm81fq1 462 8 of of IN cord-013590-pkm81fq1 462 9 the the DT cord-013590-pkm81fq1 462 10 Vγ9Vδ2 vγ9vδ2 JJ cord-013590-pkm81fq1 462 11 TCR TCR NNP cord-013590-pkm81fq1 462 12 and and CC cord-013590-pkm81fq1 462 13 is be VBZ cord-013590-pkm81fq1 462 14 essential essential JJ cord-013590-pkm81fq1 462 15 for for IN cord-013590-pkm81fq1 462 16 phosphoantigen phosphoantigen NNP cord-013590-pkm81fq1 462 17 sensing sensing NN cord-013590-pkm81fq1 462 18 Vγ2Vδ2 Vγ2Vδ2 NNP cord-013590-pkm81fq1 462 19 T T NNP cord-013590-pkm81fq1 462 20 cell cell NN cord-013590-pkm81fq1 462 21 receptor receptor NN cord-013590-pkm81fq1 462 22 recognition recognition NN cord-013590-pkm81fq1 462 23 of of IN cord-013590-pkm81fq1 462 24 prenyl prenyl NNP cord-013590-pkm81fq1 462 25 pyrophosphates pyrophosphates NNPS cord-013590-pkm81fq1 462 26 is be VBZ cord-013590-pkm81fq1 462 27 dependent dependent JJ cord-013590-pkm81fq1 462 28 on on IN cord-013590-pkm81fq1 462 29 All all DT cord-013590-pkm81fq1 462 30 CDRs CDRs NNPS cord-013590-pkm81fq1 462 31 Skint1 Skint1 NNP cord-013590-pkm81fq1 462 32 , , , cord-013590-pkm81fq1 462 33 the the DT cord-013590-pkm81fq1 462 34 prototype prototype NN cord-013590-pkm81fq1 462 35 of of IN cord-013590-pkm81fq1 462 36 a a DT cord-013590-pkm81fq1 462 37 newly newly RB cord-013590-pkm81fq1 462 38 identified identify VBN cord-013590-pkm81fq1 462 39 immunoglobulin immunoglobulin NN cord-013590-pkm81fq1 462 40 superfamily superfamily NN cord-013590-pkm81fq1 462 41 gene gene NN cord-013590-pkm81fq1 462 42 cluster cluster NN cord-013590-pkm81fq1 462 43 , , , cord-013590-pkm81fq1 462 44 positively positively RB cord-013590-pkm81fq1 462 45 selects select VBZ cord-013590-pkm81fq1 462 46 epidermal epidermal JJ cord-013590-pkm81fq1 462 47 γδ γδ IN cord-013590-pkm81fq1 462 48 T t NN cord-013590-pkm81fq1 462 49 cells cell NNS cord-013590-pkm81fq1 463 1 Skint-1 Skint-1 NNP cord-013590-pkm81fq1 463 2 is be VBZ cord-013590-pkm81fq1 463 3 a a DT cord-013590-pkm81fq1 463 4 highly highly RB cord-013590-pkm81fq1 463 5 specific specific JJ cord-013590-pkm81fq1 463 6 , , , cord-013590-pkm81fq1 463 7 unique unique JJ cord-013590-pkm81fq1 463 8 selecting select VBG cord-013590-pkm81fq1 463 9 component component NN cord-013590-pkm81fq1 463 10 for for IN cord-013590-pkm81fq1 463 11 epidermal epidermal JJ cord-013590-pkm81fq1 463 12 T t NN cord-013590-pkm81fq1 463 13 cells cell NNS cord-013590-pkm81fq1 463 14 Skint-1 skint-1 POS cord-013590-pkm81fq1 463 15 identifies identify VBZ cord-013590-pkm81fq1 463 16 a a DT cord-013590-pkm81fq1 463 17 common common JJ cord-013590-pkm81fq1 463 18 molecular molecular JJ cord-013590-pkm81fq1 463 19 mechanism mechanism NN cord-013590-pkm81fq1 463 20 for for IN cord-013590-pkm81fq1 463 21 the the DT cord-013590-pkm81fq1 463 22 development development NN cord-013590-pkm81fq1 463 23 of of IN cord-013590-pkm81fq1 463 24 interferon interferon NN cord-013590-pkm81fq1 463 25 - - HYPH cord-013590-pkm81fq1 463 26 γ γ NN cord-013590-pkm81fq1 463 27 - - HYPH cord-013590-pkm81fq1 463 28 secreting secrete VBG cord-013590-pkm81fq1 463 29 versus versus IN cord-013590-pkm81fq1 463 30 interleukin-17-secreting interleukin-17-secreting NNP cord-013590-pkm81fq1 463 31 γδ γδ CC cord-013590-pkm81fq1 463 32 T t NN cord-013590-pkm81fq1 463 33 cells cell NNS cord-013590-pkm81fq1 463 34 Positive positive JJ cord-013590-pkm81fq1 463 35 selection selection NN cord-013590-pkm81fq1 463 36 of of IN cord-013590-pkm81fq1 463 37 dendritic dendritic JJ cord-013590-pkm81fq1 463 38 epidermal epidermal NN cord-013590-pkm81fq1 463 39 γδ γδ IN cord-013590-pkm81fq1 463 40 T t NN cord-013590-pkm81fq1 463 41 cell cell NN cord-013590-pkm81fq1 463 42 precursors precursor NNS cord-013590-pkm81fq1 463 43 in in IN cord-013590-pkm81fq1 463 44 the the DT cord-013590-pkm81fq1 463 45 fetal fetal JJ cord-013590-pkm81fq1 463 46 thymus thymus NN cord-013590-pkm81fq1 463 47 determines determine VBZ cord-013590-pkm81fq1 463 48 expression expression NN cord-013590-pkm81fq1 463 49 of of IN cord-013590-pkm81fq1 463 50 skin skin NN cord-013590-pkm81fq1 463 51 - - HYPH cord-013590-pkm81fq1 463 52 homing home VBG cord-013590-pkm81fq1 463 53 receptors receptor NNS cord-013590-pkm81fq1 463 54 Selection Selection NNP cord-013590-pkm81fq1 463 55 of of IN cord-013590-pkm81fq1 463 56 the the DT cord-013590-pkm81fq1 463 57 cutaneous cutaneous JJ cord-013590-pkm81fq1 463 58 intraepithelial intraepithelial NN cord-013590-pkm81fq1 463 59 γδ+ γδ+ NN cord-013590-pkm81fq1 463 60 T t NN cord-013590-pkm81fq1 463 61 cell cell NN cord-013590-pkm81fq1 463 62 repertoire repertoire NN cord-013590-pkm81fq1 463 63 by by IN cord-013590-pkm81fq1 463 64 a a DT cord-013590-pkm81fq1 463 65 thymic thymic JJ cord-013590-pkm81fq1 463 66 stromal stromal NN cord-013590-pkm81fq1 463 67 determinant determinant NN cord-013590-pkm81fq1 463 68 Characterization characterization NN cord-013590-pkm81fq1 463 69 of of IN cord-013590-pkm81fq1 463 70 a a DT cord-013590-pkm81fq1 463 71 putative putative JJ cord-013590-pkm81fq1 463 72 receptor receptor NN cord-013590-pkm81fq1 463 73 binding bind VBG cord-013590-pkm81fq1 463 74 surface surface NN cord-013590-pkm81fq1 463 75 on on IN cord-013590-pkm81fq1 463 76 skint-1 skint-1 NNP cord-013590-pkm81fq1 463 77 , , , cord-013590-pkm81fq1 463 78 a a DT cord-013590-pkm81fq1 463 79 critical critical JJ cord-013590-pkm81fq1 463 80 determinant determinant NN cord-013590-pkm81fq1 463 81 of of IN cord-013590-pkm81fq1 463 82 dendritic dendritic JJ cord-013590-pkm81fq1 463 83 epidermal epidermal JJ cord-013590-pkm81fq1 463 84 t t NNP cord-013590-pkm81fq1 463 85 cell cell NN cord-013590-pkm81fq1 463 86 selection selection NN cord-013590-pkm81fq1 464 1 Epithelia Epithelia NNP cord-013590-pkm81fq1 464 2 use use VBP cord-013590-pkm81fq1 464 3 butyrophilin butyrophilin NN cord-013590-pkm81fq1 464 4 - - HYPH cord-013590-pkm81fq1 464 5 like like JJ cord-013590-pkm81fq1 464 6 molecules molecule NNS cord-013590-pkm81fq1 464 7 to to TO cord-013590-pkm81fq1 464 8 shape shape VB cord-013590-pkm81fq1 464 9 organ organ NN cord-013590-pkm81fq1 464 10 - - HYPH cord-013590-pkm81fq1 464 11 specific specific JJ cord-013590-pkm81fq1 464 12 γδ γδ IN cord-013590-pkm81fq1 464 13 T t NN cord-013590-pkm81fq1 464 14 cell cell NN cord-013590-pkm81fq1 464 15 compartments compartment NNS cord-013590-pkm81fq1 465 1 The the DT cord-013590-pkm81fq1 465 2 γδTCR γδTCR VBG cord-013590-pkm81fq1 465 3 combines combine VBZ cord-013590-pkm81fq1 465 4 innate innate JJ cord-013590-pkm81fq1 465 5 immunity immunity NN cord-013590-pkm81fq1 465 6 with with IN cord-013590-pkm81fq1 465 7 adaptive adaptive JJ cord-013590-pkm81fq1 465 8 immunity immunity NN cord-013590-pkm81fq1 465 9 by by IN cord-013590-pkm81fq1 465 10 utilizing utilize VBG cord-013590-pkm81fq1 465 11 spatially spatially RB cord-013590-pkm81fq1 465 12 distinct distinct JJ cord-013590-pkm81fq1 465 13 regions region NNS cord-013590-pkm81fq1 465 14 for for IN cord-013590-pkm81fq1 465 15 agonist agonist NN cord-013590-pkm81fq1 465 16 selection selection NN cord-013590-pkm81fq1 465 17 and and CC cord-013590-pkm81fq1 465 18 antigen antigen NN cord-013590-pkm81fq1 465 19 responsiveness responsiveness NN cord-013590-pkm81fq1 465 20 Butyrophilin Butyrophilin NNP cord-013590-pkm81fq1 465 21 - - HYPH cord-013590-pkm81fq1 465 22 like like JJ cord-013590-pkm81fq1 465 23 3 3 CD cord-013590-pkm81fq1 465 24 directly directly RB cord-013590-pkm81fq1 465 25 binds bind VBZ cord-013590-pkm81fq1 465 26 a a DT cord-013590-pkm81fq1 465 27 human human JJ cord-013590-pkm81fq1 465 28 Vγ4 vγ4 NN cord-013590-pkm81fq1 465 29 + + CC cord-013590-pkm81fq1 465 30 T t NN cord-013590-pkm81fq1 465 31 cell cell NN cord-013590-pkm81fq1 465 32 receptor receptor NN cord-013590-pkm81fq1 465 33 using use VBG cord-013590-pkm81fq1 465 34 a a DT cord-013590-pkm81fq1 465 35 modality modality NN cord-013590-pkm81fq1 465 36 distinct distinct JJ cord-013590-pkm81fq1 465 37 from from IN cord-013590-pkm81fq1 465 38 clonally clonally RB cord-013590-pkm81fq1 465 39 - - HYPH cord-013590-pkm81fq1 465 40 restricted restrict VBN cord-013590-pkm81fq1 465 41 antigen antigen NN cord-013590-pkm81fq1 465 42 Ligand Ligand NNP cord-013590-pkm81fq1 465 43 recognition recognition NN cord-013590-pkm81fq1 465 44 by by IN cord-013590-pkm81fq1 465 45 the the DT cord-013590-pkm81fq1 465 46 γδ γδ NNP cord-013590-pkm81fq1 465 47 TCR TCR NNP cord-013590-pkm81fq1 465 48 and and CC cord-013590-pkm81fq1 465 49 discrimination discrimination NN cord-013590-pkm81fq1 465 50 between between IN cord-013590-pkm81fq1 465 51 homeostasis homeostasis NN cord-013590-pkm81fq1 465 52 Structure Structure NNP cord-013590-pkm81fq1 465 53 of of IN cord-013590-pkm81fq1 465 54 the the DT cord-013590-pkm81fq1 465 55 superantigen superantigen NN cord-013590-pkm81fq1 465 56 Staphylococcal Staphylococcal NNP cord-013590-pkm81fq1 465 57 Enterotoxin Enterotoxin NNP cord-013590-pkm81fq1 465 58 B B NNP cord-013590-pkm81fq1 465 59 in in IN cord-013590-pkm81fq1 465 60 complex complex NN cord-013590-pkm81fq1 465 61 with with IN cord-013590-pkm81fq1 465 62 TCR TCR NNP cord-013590-pkm81fq1 465 63 and and CC cord-013590-pkm81fq1 465 64 peptide peptide NN cord-013590-pkm81fq1 465 65 - - HYPH cord-013590-pkm81fq1 465 66 MHC MHC NNP cord-013590-pkm81fq1 466 1 demonstrates demonstrate VBZ cord-013590-pkm81fq1 466 2 absence absence NN cord-013590-pkm81fq1 466 3 of of IN cord-013590-pkm81fq1 466 4 TCR TCR NNP cord-013590-pkm81fq1 466 5 - - HYPH cord-013590-pkm81fq1 466 6 peptide peptide NN cord-013590-pkm81fq1 466 7 contacts contact NNS cord-013590-pkm81fq1 466 8 Antigen Antigen NNP cord-013590-pkm81fq1 466 9 recognition recognition NN cord-013590-pkm81fq1 466 10 by by IN cord-013590-pkm81fq1 466 11 gammadelta gammadelta NNP cord-013590-pkm81fq1 466 12 T T NNP cord-013590-pkm81fq1 466 13 cells cell NNS cord-013590-pkm81fq1 466 14 Recognition Recognition NNP cord-013590-pkm81fq1 466 15 of of IN cord-013590-pkm81fq1 466 16 Listeria Listeria NNP cord-013590-pkm81fq1 466 17 infection infection NN cord-013590-pkm81fq1 466 18 by by IN cord-013590-pkm81fq1 466 19 germline germline JJ cord-013590-pkm81fq1 466 20 elements element NNS cord-013590-pkm81fq1 466 21 of of IN cord-013590-pkm81fq1 466 22 the the DT cord-013590-pkm81fq1 466 23 Vγ1.1 vγ1.1 NN cord-013590-pkm81fq1 466 24 Vδ6.3 Vδ6.3 NNP cord-013590-pkm81fq1 466 25 TCR TCR NNP cord-013590-pkm81fq1 466 26 Activation Activation NNP cord-013590-pkm81fq1 466 27 of of IN cord-013590-pkm81fq1 466 28 TCR TCR NNP cord-013590-pkm81fq1 466 29 Vδ1 Vδ1 NNP cord-013590-pkm81fq1 466 30 + + SYM cord-013590-pkm81fq1 466 31 and and CC cord-013590-pkm81fq1 466 32 Vδ1 Vδ1 NNP cord-013590-pkm81fq1 466 33 − − NNP cord-013590-pkm81fq1 466 34 Vδ2 Vδ2 NNP cord-013590-pkm81fq1 466 35 − − NNP cord-013590-pkm81fq1 466 36 γδ γδ CC cord-013590-pkm81fq1 466 37 T T NNP cord-013590-pkm81fq1 466 38 cells cell NNS cord-013590-pkm81fq1 466 39 upon upon IN cord-013590-pkm81fq1 466 40 controlled control VBN cord-013590-pkm81fq1 466 41 infection infection NN cord-013590-pkm81fq1 466 42 with with IN cord-013590-pkm81fq1 466 43 Plasmodium Plasmodium NNP cord-013590-pkm81fq1 466 44 falciparum falciparum NN cord-013590-pkm81fq1 466 45 in in IN cord-013590-pkm81fq1 466 46 Tanzanian tanzanian JJ cord-013590-pkm81fq1 466 47 volunteers volunteer NNS cord-013590-pkm81fq1 467 1 The the DT cord-013590-pkm81fq1 467 2 specificity specificity NN cord-013590-pkm81fq1 467 3 of of IN cord-013590-pkm81fq1 467 4 a a DT cord-013590-pkm81fq1 467 5 weak weak JJ cord-013590-pkm81fq1 467 6 gamma gamma NN cord-013590-pkm81fq1 467 7 delta delta NN cord-013590-pkm81fq1 467 8 TCR TCR NNP cord-013590-pkm81fq1 467 9 interaction interaction NN cord-013590-pkm81fq1 467 10 can can MD cord-013590-pkm81fq1 467 11 be be VB cord-013590-pkm81fq1 467 12 modulated modulate VBN cord-013590-pkm81fq1 467 13 by by IN cord-013590-pkm81fq1 467 14 the the DT cord-013590-pkm81fq1 467 15 glycosylation glycosylation NN cord-013590-pkm81fq1 467 16 of of IN cord-013590-pkm81fq1 467 17 the the DT cord-013590-pkm81fq1 467 18 ligand ligand NN cord-013590-pkm81fq1 467 19 Altered alter VBN cord-013590-pkm81fq1 467 20 expression expression NN cord-013590-pkm81fq1 467 21 of of IN cord-013590-pkm81fq1 467 22 Butyrophilin Butyrophilin NNP cord-013590-pkm81fq1 467 23 ( ( -LRB- cord-013590-pkm81fq1 467 24 BTN BTN NNP cord-013590-pkm81fq1 467 25 ) ) -RRB- cord-013590-pkm81fq1 467 26 and and CC cord-013590-pkm81fq1 467 27 BTNlike BTNlike NNP cord-013590-pkm81fq1 467 28 ( ( -LRB- cord-013590-pkm81fq1 467 29 BTNL BTNL NNP cord-013590-pkm81fq1 467 30 ) ) -RRB- cord-013590-pkm81fq1 467 31 genes gene NNS cord-013590-pkm81fq1 467 32 in in IN cord-013590-pkm81fq1 467 33 intestinal intestinal JJ cord-013590-pkm81fq1 467 34 inflammation inflammation NN cord-013590-pkm81fq1 467 35 and and CC cord-013590-pkm81fq1 467 36 colon colon NN cord-013590-pkm81fq1 467 37 cancer cancer NN cord-013590-pkm81fq1 467 38 Chronic Chronic NNP cord-013590-pkm81fq1 467 39 inflammation inflammation NN cord-013590-pkm81fq1 467 40 permanently permanently RB cord-013590-pkm81fq1 467 41 reshapes reshape VBZ cord-013590-pkm81fq1 467 42 tissue tissue NN cord-013590-pkm81fq1 467 43 - - HYPH cord-013590-pkm81fq1 467 44 resident resident NN cord-013590-pkm81fq1 467 45 immunity immunity NN cord-013590-pkm81fq1 467 46 in in IN cord-013590-pkm81fq1 467 47 celiac celiac JJ cord-013590-pkm81fq1 467 48 disease disease NN cord-013590-pkm81fq1 467 49 Searching search VBG cord-013590-pkm81fq1 467 50 for for IN cord-013590-pkm81fq1 467 51 ' ' `` cord-013590-pkm81fq1 467 52 signal signal NN cord-013590-pkm81fq1 467 53 2 2 CD cord-013590-pkm81fq1 467 54 ' ' '' cord-013590-pkm81fq1 467 55 : : : cord-013590-pkm81fq1 468 1 Costimulation costimulation NN cord-013590-pkm81fq1 468 2 requirements requirement NNS cord-013590-pkm81fq1 468 3 of of IN cord-013590-pkm81fq1 468 4 γδ γδ NN cord-013590-pkm81fq1 468 5 T T NNP cord-013590-pkm81fq1 468 6 cells cell NNS cord-013590-pkm81fq1 468 7 Human Human NNP cord-013590-pkm81fq1 468 8 T T NNP cord-013590-pkm81fq1 468 9 cell cell NN cord-013590-pkm81fq1 468 10 clones clone NNS cord-013590-pkm81fq1 468 11 with with IN cord-013590-pkm81fq1 468 12 γ γ NN cord-013590-pkm81fq1 468 13 δ δ NN cord-013590-pkm81fq1 468 14 and and CC cord-013590-pkm81fq1 468 15 α α NN cord-013590-pkm81fq1 468 16 β β NN cord-013590-pkm81fq1 468 17 receptors receptor NNS cord-013590-pkm81fq1 468 18 are be VBP cord-013590-pkm81fq1 468 19 differently differently RB cord-013590-pkm81fq1 468 20 stimulated stimulate VBN cord-013590-pkm81fq1 468 21 by by IN cord-013590-pkm81fq1 468 22 monoclonal monoclonal JJ cord-013590-pkm81fq1 468 23 antibodies antibody NNS cord-013590-pkm81fq1 468 24 to to IN cord-013590-pkm81fq1 468 25 CD2 CD2 NNP cord-013590-pkm81fq1 468 26 Selective selective JJ cord-013590-pkm81fq1 468 27 activation activation NN cord-013590-pkm81fq1 468 28 of of IN cord-013590-pkm81fq1 468 29 γ γ NN cord-013590-pkm81fq1 468 30 / / SYM cord-013590-pkm81fq1 468 31 δ δ NN cord-013590-pkm81fq1 468 32 T T NNP cord-013590-pkm81fq1 468 33 cell cell NN cord-013590-pkm81fq1 468 34 clones clone NNS cord-013590-pkm81fq1 468 35 by by IN cord-013590-pkm81fq1 468 36 single single JJ cord-013590-pkm81fq1 468 37 anti anti JJ cord-013590-pkm81fq1 468 38 - - JJ cord-013590-pkm81fq1 468 39 CD2 cd2 JJ cord-013590-pkm81fq1 468 40 antibodies antibody NNS cord-013590-pkm81fq1 468 41 Functional functional JJ cord-013590-pkm81fq1 468 42 expression expression NN cord-013590-pkm81fq1 468 43 of of IN cord-013590-pkm81fq1 468 44 CD28 CD28 NNP cord-013590-pkm81fq1 468 45 on on IN cord-013590-pkm81fq1 468 46 T T NNP cord-013590-pkm81fq1 468 47 cell cell NN cord-013590-pkm81fq1 468 48 antigen antigen NN cord-013590-pkm81fq1 468 49 receptor receptor NN cord-013590-pkm81fq1 468 50 γ/ γ/ NNP cord-013590-pkm81fq1 469 1 δ δ LS cord-013590-pkm81fq1 469 2 - - HYPH cord-013590-pkm81fq1 469 3 bearing bear VBG cord-013590-pkm81fq1 469 4 T T NNP cord-013590-pkm81fq1 469 5 lymphocytes lymphocyte NNS cord-013590-pkm81fq1 469 6 Cellular cellular JJ cord-013590-pkm81fq1 469 7 and and CC cord-013590-pkm81fq1 469 8 molecular molecular JJ cord-013590-pkm81fq1 469 9 basis basis NN cord-013590-pkm81fq1 469 10 of of IN cord-013590-pkm81fq1 469 11 human human NN cord-013590-pkm81fq1 469 12 γδ γδ IN cord-013590-pkm81fq1 469 13 T T NNP cord-013590-pkm81fq1 469 14 cell cell NN cord-013590-pkm81fq1 469 15 activation activation NN cord-013590-pkm81fq1 469 16 . . . cord-013590-pkm81fq1 470 1 Role role NN cord-013590-pkm81fq1 470 2 of of IN cord-013590-pkm81fq1 470 3 accessory accessory JJ cord-013590-pkm81fq1 470 4 molecules molecule NNS cord-013590-pkm81fq1 470 5 in in IN cord-013590-pkm81fq1 470 6 alloactivation alloactivation NN cord-013590-pkm81fq1 471 1 CD70-CD27 CD70-CD27 NNP cord-013590-pkm81fq1 471 2 interactions interaction NNS cord-013590-pkm81fq1 471 3 provide provide VBP cord-013590-pkm81fq1 471 4 survival survival NN cord-013590-pkm81fq1 471 5 and and CC cord-013590-pkm81fq1 471 6 proliferative proliferative JJ cord-013590-pkm81fq1 471 7 signals signal NNS cord-013590-pkm81fq1 471 8 that that WDT cord-013590-pkm81fq1 471 9 regulate regulate VBP cord-013590-pkm81fq1 471 10 T T NNP cord-013590-pkm81fq1 471 11 cell cell NN cord-013590-pkm81fq1 471 12 receptor receptor NN cord-013590-pkm81fq1 471 13 - - HYPH cord-013590-pkm81fq1 471 14 driven drive VBN cord-013590-pkm81fq1 471 15 activation activation NN cord-013590-pkm81fq1 471 16 of of IN cord-013590-pkm81fq1 471 17 human human NN cord-013590-pkm81fq1 471 18 γδ γδ IN cord-013590-pkm81fq1 471 19 peripheral peripheral JJ cord-013590-pkm81fq1 471 20 blood blood NN cord-013590-pkm81fq1 471 21 lymphocytes lymphocyte NNS cord-013590-pkm81fq1 472 1 The the DT cord-013590-pkm81fq1 472 2 junctional junctional JJ cord-013590-pkm81fq1 472 3 adhesion adhesion NN cord-013590-pkm81fq1 472 4 molecule molecule NN cord-013590-pkm81fq1 472 5 JAML JAML NNP cord-013590-pkm81fq1 472 6 is be VBZ cord-013590-pkm81fq1 472 7 a a DT cord-013590-pkm81fq1 472 8 costimulatory costimulatory NN cord-013590-pkm81fq1 472 9 receptor receptor NN cord-013590-pkm81fq1 472 10 for for IN cord-013590-pkm81fq1 472 11 epithelial epithelial JJ cord-013590-pkm81fq1 472 12 T T NNP cord-013590-pkm81fq1 472 13 cell cell NN cord-013590-pkm81fq1 472 14 activation activation NN cord-013590-pkm81fq1 472 15 γδT γδt NN cord-013590-pkm81fq1 472 16 cells cell NNS cord-013590-pkm81fq1 472 17 elicited elicit VBN cord-013590-pkm81fq1 472 18 by by IN cord-013590-pkm81fq1 472 19 CMV CMV NNP cord-013590-pkm81fq1 472 20 reactivation reactivation NN cord-013590-pkm81fq1 472 21 after after IN cord-013590-pkm81fq1 472 22 allo allo NN cord-013590-pkm81fq1 472 23 - - HYPH cord-013590-pkm81fq1 472 24 SCT SCT NNP cord-013590-pkm81fq1 472 25 crossrecognize crossrecognize NN cord-013590-pkm81fq1 472 26 CMV CMV NNP cord-013590-pkm81fq1 472 27 and and CC cord-013590-pkm81fq1 472 28 leukemia leukemia NN cord-013590-pkm81fq1 472 29 CD8 CD8 NNP cord-013590-pkm81fq1 472 30 + + CC cord-013590-pkm81fq1 472 31 γδ γδ NNP cord-013590-pkm81fq1 472 32 T t NN cord-013590-pkm81fq1 472 33 cells cell NNS cord-013590-pkm81fq1 472 34 are be VBP cord-013590-pkm81fq1 472 35 more more RBR cord-013590-pkm81fq1 472 36 frequent frequent JJ cord-013590-pkm81fq1 472 37 in in IN cord-013590-pkm81fq1 472 38 CMV CMV NNP cord-013590-pkm81fq1 472 39 seropositive seropositive JJ cord-013590-pkm81fq1 472 40 bone bone NN cord-013590-pkm81fq1 472 41 marrow marrow NN cord-013590-pkm81fq1 472 42 grafts graft NNS cord-013590-pkm81fq1 472 43 and and CC cord-013590-pkm81fq1 472 44 display display NN cord-013590-pkm81fq1 472 45 phenotype phenotype NN cord-013590-pkm81fq1 472 46 of of IN cord-013590-pkm81fq1 472 47 an an DT cord-013590-pkm81fq1 472 48 adaptive adaptive JJ cord-013590-pkm81fq1 472 49 immune immune JJ cord-013590-pkm81fq1 472 50 response response NN cord-013590-pkm81fq1 473 1 MICA MICA NNP cord-013590-pkm81fq1 473 2 engagement engagement NN cord-013590-pkm81fq1 473 3 by by IN cord-013590-pkm81fq1 473 4 human human JJ cord-013590-pkm81fq1 473 5 Vγ2Vδ2 Vγ2Vδ2 NNP cord-013590-pkm81fq1 473 6 T T NNP cord-013590-pkm81fq1 473 7 cells cell NNS cord-013590-pkm81fq1 473 8 enhances enhance VBZ cord-013590-pkm81fq1 473 9 their -PRON- PRP$ cord-013590-pkm81fq1 473 10 antigen antigen NN cord-013590-pkm81fq1 473 11 - - HYPH cord-013590-pkm81fq1 473 12 dependent dependent JJ cord-013590-pkm81fq1 473 13 effector effector NN cord-013590-pkm81fq1 473 14 function function NN cord-013590-pkm81fq1 474 1 NKG2D NKG2D NNP cord-013590-pkm81fq1 474 2 costimulates costimulates NNP cord-013590-pkm81fq1 474 3 human human NNP cord-013590-pkm81fq1 474 4 Vγ9Vδ2 Vγ9Vδ2 NNP cord-013590-pkm81fq1 474 5 T T NNP cord-013590-pkm81fq1 474 6 cell cell NN cord-013590-pkm81fq1 474 7 antitumor antitumor NN cord-013590-pkm81fq1 474 8 cytotoxicity cytotoxicity NN cord-013590-pkm81fq1 474 9 through through IN cord-013590-pkm81fq1 474 10 protein protein NN cord-013590-pkm81fq1 474 11 kinase kinase NN cord-013590-pkm81fq1 474 12 Cθ cθ NN cord-013590-pkm81fq1 474 13 - - HYPH cord-013590-pkm81fq1 474 14 dependent dependent JJ cord-013590-pkm81fq1 474 15 modulation modulation NN cord-013590-pkm81fq1 474 16 of of IN cord-013590-pkm81fq1 474 17 early early JJ cord-013590-pkm81fq1 474 18 TCR TCR NNP cord-013590-pkm81fq1 474 19 - - HYPH cord-013590-pkm81fq1 474 20 induced induce VBN cord-013590-pkm81fq1 474 21 calcium calcium NN cord-013590-pkm81fq1 474 22 and and CC cord-013590-pkm81fq1 474 23 transduction transduction NN cord-013590-pkm81fq1 474 24 signals signal VBZ cord-013590-pkm81fq1 474 25 Activation Activation NNP cord-013590-pkm81fq1 474 26 of of IN cord-013590-pkm81fq1 474 27 Vγ9Vδ2 Vγ9Vδ2 NNS cord-013590-pkm81fq1 474 28 T t NN cord-013590-pkm81fq1 474 29 cells cell NNS cord-013590-pkm81fq1 474 30 by by IN cord-013590-pkm81fq1 474 31 NKG2D nkg2d NN cord-013590-pkm81fq1 475 1 Infection infection NN cord-013590-pkm81fq1 475 2 with with IN cord-013590-pkm81fq1 475 3 listeria listeria NN cord-013590-pkm81fq1 475 4 monocytogenes monocytogenes NN cord-013590-pkm81fq1 475 5 impairs impair VBZ cord-013590-pkm81fq1 475 6 sialic sialic JJ cord-013590-pkm81fq1 475 7 acid acid NN cord-013590-pkm81fq1 475 8 addition addition NN cord-013590-pkm81fq1 475 9 to to TO cord-013590-pkm81fq1 475 10 host host VB cord-013590-pkm81fq1 475 11 cell cell NN cord-013590-pkm81fq1 475 12 glycoproteins glycoprotein NNS cord-013590-pkm81fq1 475 13 Mucin mucin NN cord-013590-pkm81fq1 475 14 antibodies antibody NNS cord-013590-pkm81fq1 475 15 - - : cord-013590-pkm81fq1 475 16 new new JJ cord-013590-pkm81fq1 475 17 tools tool NNS cord-013590-pkm81fq1 475 18 in in IN cord-013590-pkm81fq1 475 19 diagnosis diagnosis NN cord-013590-pkm81fq1 475 20 and and CC cord-013590-pkm81fq1 475 21 therapy therapy NN cord-013590-pkm81fq1 475 22 of of IN cord-013590-pkm81fq1 475 23 cancer cancer NN cord-013590-pkm81fq1 475 24 Immunization Immunization NNP cord-013590-pkm81fq1 475 25 with with IN cord-013590-pkm81fq1 475 26 glycosylated glycosylated JJ cord-013590-pkm81fq1 475 27 Kb Kb NNP cord-013590-pkm81fq1 475 28 - - HYPH cord-013590-pkm81fq1 475 29 binding bind VBG cord-013590-pkm81fq1 475 30 peptides peptide NNS cord-013590-pkm81fq1 475 31 generates generate VBZ cord-013590-pkm81fq1 475 32 carbohydrate carbohydrate NN cord-013590-pkm81fq1 475 33 - - HYPH cord-013590-pkm81fq1 475 34 specific specific JJ cord-013590-pkm81fq1 475 35 , , , cord-013590-pkm81fq1 475 36 unrestricted unrestricted JJ cord-013590-pkm81fq1 475 37 cytotoxic cytotoxic JJ cord-013590-pkm81fq1 475 38 T t NN cord-013590-pkm81fq1 475 39 cells cell NNS cord-013590-pkm81fq1 475 40 Crystal Crystal NNP cord-013590-pkm81fq1 475 41 structure structure NN cord-013590-pkm81fq1 475 42 of of IN cord-013590-pkm81fq1 475 43 an an DT cord-013590-pkm81fq1 475 44 MHC MHC NNP cord-013590-pkm81fq1 475 45 class class NN cord-013590-pkm81fq1 475 46 I -PRON- PRP cord-013590-pkm81fq1 475 47 presented present VBD cord-013590-pkm81fq1 475 48 glycopeptide glycopeptide NN cord-013590-pkm81fq1 475 49 that that WDT cord-013590-pkm81fq1 475 50 generates generate VBZ cord-013590-pkm81fq1 475 51 carbohydrate carbohydrate NN cord-013590-pkm81fq1 475 52 - - HYPH cord-013590-pkm81fq1 475 53 specific specific JJ cord-013590-pkm81fq1 475 54 CTL CTL NNP cord-013590-pkm81fq1 475 55 Detection detection NN cord-013590-pkm81fq1 475 56 of of IN cord-013590-pkm81fq1 475 57 cell cell NN cord-013590-pkm81fq1 475 58 surface surface NN cord-013590-pkm81fq1 475 59 ligands ligand NNS cord-013590-pkm81fq1 475 60 for for IN cord-013590-pkm81fq1 475 61 human human JJ cord-013590-pkm81fq1 475 62 synovial synovial NN cord-013590-pkm81fq1 475 63 γδ γδ CC cord-013590-pkm81fq1 475 64 T t NN cord-013590-pkm81fq1 475 65 cells cell NNS cord-013590-pkm81fq1 475 66 Identification identification NN cord-013590-pkm81fq1 475 67 of of IN cord-013590-pkm81fq1 475 68 antigenic antigenic JJ cord-013590-pkm81fq1 475 69 targets target NNS cord-013590-pkm81fq1 475 70 Deciphering decipher VBG cord-013590-pkm81fq1 475 71 CD4 CD4 NNP cord-013590-pkm81fq1 475 72 + + CC cord-013590-pkm81fq1 475 73 T t NN cord-013590-pkm81fq1 475 74 cell cell NN cord-013590-pkm81fq1 475 75 specificity specificity NN cord-013590-pkm81fq1 475 76 using use VBG cord-013590-pkm81fq1 475 77 novel novel NN cord-013590-pkm81fq1 475 78 MHC MHC NNP cord-013590-pkm81fq1 475 79 - - HYPH cord-013590-pkm81fq1 475 80 TCR TCR NNP cord-013590-pkm81fq1 475 81 chimeric chimeric JJ cord-013590-pkm81fq1 475 82 receptors receptor NNS cord-013590-pkm81fq1 475 83 which which WDT cord-013590-pkm81fq1 475 84 permits permit VBZ cord-013590-pkm81fq1 475 85 use use NN cord-013590-pkm81fq1 475 86 , , , cord-013590-pkm81fq1 475 87 sharing sharing NN cord-013590-pkm81fq1 475 88 , , , cord-013590-pkm81fq1 475 89 adaptation adaptation NN cord-013590-pkm81fq1 475 90 , , , cord-013590-pkm81fq1 475 91 distribution distribution NN cord-013590-pkm81fq1 475 92 and and CC cord-013590-pkm81fq1 475 93 reproduction reproduction NN cord-013590-pkm81fq1 475 94 in in IN cord-013590-pkm81fq1 475 95 any any DT cord-013590-pkm81fq1 475 96 medium medium NN cord-013590-pkm81fq1 475 97 or or CC cord-013590-pkm81fq1 475 98 format format NN cord-013590-pkm81fq1 475 99 , , , cord-013590-pkm81fq1 475 100 as as RB cord-013590-pkm81fq1 475 101 long long RB cord-013590-pkm81fq1 475 102 as as IN cord-013590-pkm81fq1 475 103 you -PRON- PRP cord-013590-pkm81fq1 475 104 give give VBP cord-013590-pkm81fq1 475 105 appropriate appropriate JJ cord-013590-pkm81fq1 475 106 credit credit NN cord-013590-pkm81fq1 475 107 to to IN cord-013590-pkm81fq1 475 108 the the DT cord-013590-pkm81fq1 475 109 original original JJ cord-013590-pkm81fq1 475 110 author(s author(s NNP cord-013590-pkm81fq1 475 111 ) ) -RRB- cord-013590-pkm81fq1 475 112 and and CC cord-013590-pkm81fq1 475 113 the the DT cord-013590-pkm81fq1 475 114 source source NN cord-013590-pkm81fq1 475 115 , , , cord-013590-pkm81fq1 475 116 provide provide VB cord-013590-pkm81fq1 475 117 a a DT cord-013590-pkm81fq1 475 118 link link NN cord-013590-pkm81fq1 475 119 to to IN cord-013590-pkm81fq1 475 120 the the DT cord-013590-pkm81fq1 475 121 Creative Creative NNP cord-013590-pkm81fq1 475 122 Commons Commons NNP cord-013590-pkm81fq1 475 123 license license NN cord-013590-pkm81fq1 475 124 , , , cord-013590-pkm81fq1 475 125 and and CC cord-013590-pkm81fq1 475 126 indicate indicate VBP cord-013590-pkm81fq1 475 127 if if IN cord-013590-pkm81fq1 475 128 changes change NNS cord-013590-pkm81fq1 475 129 were be VBD cord-013590-pkm81fq1 475 130 made make VBN cord-013590-pkm81fq1 475 131 . . . cord-013590-pkm81fq1 476 1 The the DT cord-013590-pkm81fq1 476 2 images image NNS cord-013590-pkm81fq1 476 3 or or CC cord-013590-pkm81fq1 476 4 other other JJ cord-013590-pkm81fq1 476 5 third third JJ cord-013590-pkm81fq1 476 6 party party NN cord-013590-pkm81fq1 476 7 material material NN cord-013590-pkm81fq1 476 8 in in IN cord-013590-pkm81fq1 476 9 this this DT cord-013590-pkm81fq1 476 10 article article NN cord-013590-pkm81fq1 476 11 are be VBP cord-013590-pkm81fq1 476 12 included include VBN cord-013590-pkm81fq1 476 13 in in IN cord-013590-pkm81fq1 476 14 the the DT cord-013590-pkm81fq1 476 15 article article NN cord-013590-pkm81fq1 476 16 's 's POS cord-013590-pkm81fq1 476 17 Creative Creative NNP cord-013590-pkm81fq1 476 18 Commons Commons NNP cord-013590-pkm81fq1 476 19 license license NN cord-013590-pkm81fq1 476 20 , , , cord-013590-pkm81fq1 476 21 unless unless IN cord-013590-pkm81fq1 476 22 indicated indicate VBN cord-013590-pkm81fq1 476 23 otherwise otherwise RB cord-013590-pkm81fq1 476 24 in in IN cord-013590-pkm81fq1 476 25 a a DT cord-013590-pkm81fq1 476 26 credit credit NN cord-013590-pkm81fq1 476 27 line line NN cord-013590-pkm81fq1 476 28 to to IN cord-013590-pkm81fq1 476 29 the the DT cord-013590-pkm81fq1 476 30 material material NN cord-013590-pkm81fq1 476 31 . . . cord-013590-pkm81fq1 477 1 If if IN cord-013590-pkm81fq1 477 2 material material NN cord-013590-pkm81fq1 477 3 is be VBZ cord-013590-pkm81fq1 477 4 not not RB cord-013590-pkm81fq1 477 5 included include VBN cord-013590-pkm81fq1 477 6 in in IN cord-013590-pkm81fq1 477 7 the the DT cord-013590-pkm81fq1 477 8 article article NN cord-013590-pkm81fq1 477 9 's 's POS cord-013590-pkm81fq1 477 10 Creative Creative NNP cord-013590-pkm81fq1 477 11 Commons Commons NNP cord-013590-pkm81fq1 477 12 license license NN cord-013590-pkm81fq1 477 13 and and CC cord-013590-pkm81fq1 477 14 your -PRON- PRP$ cord-013590-pkm81fq1 477 15 intended intend VBN cord-013590-pkm81fq1 477 16 use use NN cord-013590-pkm81fq1 477 17 is be VBZ cord-013590-pkm81fq1 477 18 not not RB cord-013590-pkm81fq1 477 19 permitted permit VBN cord-013590-pkm81fq1 477 20 by by IN cord-013590-pkm81fq1 477 21 statutory statutory JJ cord-013590-pkm81fq1 477 22 regulation regulation NN cord-013590-pkm81fq1 477 23 or or CC cord-013590-pkm81fq1 477 24 exceeds exceed VBZ cord-013590-pkm81fq1 477 25 the the DT cord-013590-pkm81fq1 477 26 permitted permit VBN cord-013590-pkm81fq1 477 27 use use NN cord-013590-pkm81fq1 477 28 , , , cord-013590-pkm81fq1 477 29 you -PRON- PRP cord-013590-pkm81fq1 477 30 will will MD cord-013590-pkm81fq1 477 31 need need VB cord-013590-pkm81fq1 477 32 to to TO cord-013590-pkm81fq1 477 33 obtain obtain VB cord-013590-pkm81fq1 477 34 permission permission NN cord-013590-pkm81fq1 477 35 directly directly RB cord-013590-pkm81fq1 477 36 from from IN cord-013590-pkm81fq1 477 37 the the DT cord-013590-pkm81fq1 477 38 copyright copyright NN cord-013590-pkm81fq1 477 39 holder holder NN cord-013590-pkm81fq1 477 40 Competing compete VBG cord-013590-pkm81fq1 477 41 interests interest NNS cord-013590-pkm81fq1 477 42 : : : cord-013590-pkm81fq1 478 1 The the DT cord-013590-pkm81fq1 478 2 authors author NNS cord-013590-pkm81fq1 478 3 declare declare VBP cord-013590-pkm81fq1 478 4 no no DT cord-013590-pkm81fq1 478 5 competing compete VBG cord-013590-pkm81fq1 478 6 interests interest NNS cord-013590-pkm81fq1 478 7 . . .