id sid tid token lemma pos cord-259669-fod4xkd7 1 1 key key JJ cord-259669-fod4xkd7 1 2 : : : cord-259669-fod4xkd7 1 3 cord-259669-fod4xkd7 cord-259669-fod4xkd7 NN cord-259669-fod4xkd7 1 4 authors author NNS cord-259669-fod4xkd7 1 5 : : : cord-259669-fod4xkd7 1 6 Summerfield Summerfield NNP cord-259669-fod4xkd7 1 7 , , , cord-259669-fod4xkd7 1 8 Artur Artur NNP cord-259669-fod4xkd7 1 9 ; ; : cord-259669-fod4xkd7 1 10 McCullough McCullough NNP cord-259669-fod4xkd7 1 11 , , , cord-259669-fod4xkd7 2 1 Kenneth Kenneth NNP cord-259669-fod4xkd7 2 2 C. C. NNP cord-259669-fod4xkd7 2 3 title title NN cord-259669-fod4xkd7 2 4 : : : cord-259669-fod4xkd7 3 1 The the DT cord-259669-fod4xkd7 3 2 porcine porcine JJ cord-259669-fod4xkd7 3 3 dendritic dendritic JJ cord-259669-fod4xkd7 3 4 cell cell NN cord-259669-fod4xkd7 3 5 family family NN cord-259669-fod4xkd7 3 6 date date NN cord-259669-fod4xkd7 3 7 : : : cord-259669-fod4xkd7 3 8 2008 2008 CD cord-259669-fod4xkd7 3 9 - - SYM cord-259669-fod4xkd7 3 10 06 06 CD cord-259669-fod4xkd7 3 11 - - HYPH cord-259669-fod4xkd7 3 12 06 06 CD cord-259669-fod4xkd7 3 13 journal journal NN cord-259669-fod4xkd7 3 14 : : : cord-259669-fod4xkd7 4 1 Dev Dev NNP cord-259669-fod4xkd7 4 2 Comp Comp NNP cord-259669-fod4xkd7 5 1 Immunol Immunol NNP cord-259669-fod4xkd7 5 2 DOI DOI NNP cord-259669-fod4xkd7 5 3 : : : cord-259669-fod4xkd7 5 4 10.1016 10.1016 CD cord-259669-fod4xkd7 5 5 / / SYM cord-259669-fod4xkd7 5 6 j.dci.2008.05.005 j.dci.2008.05.005 NN cord-259669-fod4xkd7 5 7 sha sha NNP cord-259669-fod4xkd7 5 8 : : : cord-259669-fod4xkd7 5 9 d640997399cfd57831f415625bc8f66170bca496 d640997399cfd57831f415625bc8f66170bca496 NNP cord-259669-fod4xkd7 5 10 doc_id doc_id CD cord-259669-fod4xkd7 5 11 : : : cord-259669-fod4xkd7 5 12 259669 259669 CD cord-259669-fod4xkd7 5 13 cord_uid cord_uid FW cord-259669-fod4xkd7 5 14 : : : cord-259669-fod4xkd7 6 1 fod4xkd7 fod4xkd7 NNP cord-259669-fod4xkd7 7 1 Considering consider VBG cord-259669-fod4xkd7 7 2 the the DT cord-259669-fod4xkd7 7 3 pivotal pivotal JJ cord-259669-fod4xkd7 7 4 roles role NNS cord-259669-fod4xkd7 7 5 played play VBN cord-259669-fod4xkd7 7 6 by by IN cord-259669-fod4xkd7 7 7 dendritic dendritic JJ cord-259669-fod4xkd7 7 8 cells cell NNS cord-259669-fod4xkd7 7 9 ( ( -LRB- cord-259669-fod4xkd7 7 10 DCs DCs NNP cord-259669-fod4xkd7 7 11 ) ) -RRB- cord-259669-fod4xkd7 7 12 in in IN cord-259669-fod4xkd7 7 13 both both DT cord-259669-fod4xkd7 7 14 innate innate JJ cord-259669-fod4xkd7 7 15 and and CC cord-259669-fod4xkd7 7 16 adaptive adaptive JJ cord-259669-fod4xkd7 7 17 immune immune JJ cord-259669-fod4xkd7 7 18 responses response NNS cord-259669-fod4xkd7 7 19 , , , cord-259669-fod4xkd7 7 20 advances advance VBZ cord-259669-fod4xkd7 7 21 in in IN cord-259669-fod4xkd7 7 22 the the DT cord-259669-fod4xkd7 7 23 field field NN cord-259669-fod4xkd7 7 24 of of IN cord-259669-fod4xkd7 7 25 porcine porcine JJ cord-259669-fod4xkd7 7 26 immunology immunology NN cord-259669-fod4xkd7 7 27 DC DC NNP cord-259669-fod4xkd7 7 28 biology biology NN cord-259669-fod4xkd7 7 29 have have VBP cord-259669-fod4xkd7 7 30 recently recently RB cord-259669-fod4xkd7 7 31 progressed progress VBN cord-259669-fod4xkd7 7 32 rapidly rapidly RB cord-259669-fod4xkd7 7 33 . . . cord-259669-fod4xkd7 8 1 As as IN cord-259669-fod4xkd7 8 2 with with IN cord-259669-fod4xkd7 8 3 the the DT cord-259669-fod4xkd7 8 4 more more RBR cord-259669-fod4xkd7 8 5 extensively extensively RB cord-259669-fod4xkd7 8 6 studied study VBN cord-259669-fod4xkd7 8 7 murine murine JJ cord-259669-fod4xkd7 8 8 and and CC cord-259669-fod4xkd7 8 9 human human JJ cord-259669-fod4xkd7 8 10 DCs dc NNS cord-259669-fod4xkd7 8 11 , , , cord-259669-fod4xkd7 8 12 porcine porcine JJ cord-259669-fod4xkd7 8 13 DC DC NNP cord-259669-fod4xkd7 8 14 can can MD cord-259669-fod4xkd7 8 15 be be VB cord-259669-fod4xkd7 8 16 generated generate VBN cord-259669-fod4xkd7 8 17 from from IN cord-259669-fod4xkd7 8 18 bone bone NN cord-259669-fod4xkd7 8 19 marrow marrow NN cord-259669-fod4xkd7 8 20 haematopoietic haematopoietic JJ cord-259669-fod4xkd7 8 21 cells cell NNS cord-259669-fod4xkd7 8 22 or or CC cord-259669-fod4xkd7 8 23 monocytes monocyte NNS cord-259669-fod4xkd7 8 24 , , , cord-259669-fod4xkd7 8 25 and and CC cord-259669-fod4xkd7 8 26 have have VBP cord-259669-fod4xkd7 8 27 been be VBN cord-259669-fod4xkd7 8 28 analysed analyse VBN cord-259669-fod4xkd7 8 29 in in IN cord-259669-fod4xkd7 8 30 various various JJ cord-259669-fod4xkd7 8 31 immunological immunological JJ cord-259669-fod4xkd7 8 32 and and CC cord-259669-fod4xkd7 8 33 non non JJ cord-259669-fod4xkd7 8 34 - - JJ cord-259669-fod4xkd7 8 35 immunological immunological JJ cord-259669-fod4xkd7 8 36 tissues tissue NNS cord-259669-fod4xkd7 8 37 . . . cord-259669-fod4xkd7 9 1 Both both DT cord-259669-fod4xkd7 9 2 conventional conventional JJ cord-259669-fod4xkd7 9 3 DC DC NNP cord-259669-fod4xkd7 9 4 ( ( -LRB- cord-259669-fod4xkd7 9 5 cDC cDC NNP cord-259669-fod4xkd7 9 6 ) ) -RRB- cord-259669-fod4xkd7 9 7 and and CC cord-259669-fod4xkd7 9 8 plasmacytoid plasmacytoid NNP cord-259669-fod4xkd7 9 9 DC DC NNP cord-259669-fod4xkd7 9 10 ( ( -LRB- cord-259669-fod4xkd7 9 11 pDC pDC NNP cord-259669-fod4xkd7 9 12 ) ) -RRB- cord-259669-fod4xkd7 9 13 have have VBP cord-259669-fod4xkd7 9 14 been be VBN cord-259669-fod4xkd7 9 15 characterized characterize VBN cord-259669-fod4xkd7 9 16 . . . cord-259669-fod4xkd7 10 1 The the DT cord-259669-fod4xkd7 10 2 function function NN cord-259669-fod4xkd7 10 3 of of IN cord-259669-fod4xkd7 10 4 porcine porcine JJ cord-259669-fod4xkd7 10 5 monocyte monocyte NNP cord-259669-fod4xkd7 10 6 - - HYPH cord-259669-fod4xkd7 10 7 derived derive VBN cord-259669-fod4xkd7 10 8 DC DC NNP cord-259669-fod4xkd7 10 9 has have VBZ cord-259669-fod4xkd7 10 10 not not RB cord-259669-fod4xkd7 10 11 only only RB cord-259669-fod4xkd7 10 12 been be VBN cord-259669-fod4xkd7 10 13 characterized characterize VBN cord-259669-fod4xkd7 10 14 in in IN cord-259669-fod4xkd7 10 15 terms term NNS cord-259669-fod4xkd7 10 16 of of IN cord-259669-fod4xkd7 10 17 antigen antigen NN cord-259669-fod4xkd7 10 18 presentation presentation NN cord-259669-fod4xkd7 10 19 and and CC cord-259669-fod4xkd7 10 20 lymphocyte lymphocyte NN cord-259669-fod4xkd7 10 21 activation activation NN cord-259669-fod4xkd7 10 22 , , , cord-259669-fod4xkd7 10 23 but but CC cord-259669-fod4xkd7 10 24 also also RB cord-259669-fod4xkd7 10 25 their -PRON- PRP$ cord-259669-fod4xkd7 10 26 response response NN cord-259669-fod4xkd7 10 27 to to IN cord-259669-fod4xkd7 10 28 various various JJ cord-259669-fod4xkd7 10 29 ligands ligand NNS cord-259669-fod4xkd7 10 30 of of IN cord-259669-fod4xkd7 10 31 pattern pattern NN cord-259669-fod4xkd7 10 32 recognition recognition NN cord-259669-fod4xkd7 10 33 receptors receptor NNS cord-259669-fod4xkd7 10 34 . . . cord-259669-fod4xkd7 11 1 These these DT cord-259669-fod4xkd7 11 2 have have VBP cord-259669-fod4xkd7 11 3 been be VBN cord-259669-fod4xkd7 11 4 characterized characterize VBN cord-259669-fod4xkd7 11 5 in in IN cord-259669-fod4xkd7 11 6 terms term NNS cord-259669-fod4xkd7 11 7 of of IN cord-259669-fod4xkd7 11 8 the the DT cord-259669-fod4xkd7 11 9 induction induction NN cord-259669-fod4xkd7 11 10 of of IN cord-259669-fod4xkd7 11 11 DC DC NNP cord-259669-fod4xkd7 11 12 maturation maturation NN cord-259669-fod4xkd7 11 13 and and CC cord-259669-fod4xkd7 11 14 pro pro JJ cord-259669-fod4xkd7 11 15 - - JJ cord-259669-fod4xkd7 11 16 inflammatory inflammatory JJ cord-259669-fod4xkd7 11 17 , , , cord-259669-fod4xkd7 11 18 Th1-like th1-like JJ cord-259669-fod4xkd7 11 19 or or CC cord-259669-fod4xkd7 11 20 Th2-like th2-like JJ cord-259669-fod4xkd7 11 21 cytokines cytokine NNS cord-259669-fod4xkd7 11 22 secretion secretion NN cord-259669-fod4xkd7 11 23 . . . cord-259669-fod4xkd7 12 1 Porcine Porcine NNP cord-259669-fod4xkd7 12 2 pDC pDC NNP cord-259669-fod4xkd7 12 3 most most RBS cord-259669-fod4xkd7 12 4 effectively effectively RB cord-259669-fod4xkd7 12 5 sense sense VBP cord-259669-fod4xkd7 12 6 virus virus NN cord-259669-fod4xkd7 12 7 infections infection NNS cord-259669-fod4xkd7 12 8 and and CC cord-259669-fod4xkd7 12 9 are be VBP cord-259669-fod4xkd7 12 10 characterized characterize VBN cord-259669-fod4xkd7 12 11 by by IN cord-259669-fod4xkd7 12 12 their -PRON- PRP$ cord-259669-fod4xkd7 12 13 capacity capacity NN cord-259669-fod4xkd7 12 14 to to TO cord-259669-fod4xkd7 12 15 produce produce VB cord-259669-fod4xkd7 12 16 large large JJ cord-259669-fod4xkd7 12 17 quantities quantity NNS cord-259669-fod4xkd7 12 18 of of IN cord-259669-fod4xkd7 12 19 IFN IFN NNP cord-259669-fod4xkd7 12 20 - - HYPH cord-259669-fod4xkd7 12 21 α α NNP cord-259669-fod4xkd7 12 22 and and CC cord-259669-fod4xkd7 12 23 the the DT cord-259669-fod4xkd7 12 24 pro pro JJ cord-259669-fod4xkd7 12 25 - - JJ cord-259669-fod4xkd7 12 26 inflammatory inflammatory JJ cord-259669-fod4xkd7 12 27 cytokines cytokine NNS cord-259669-fod4xkd7 13 1 TNF TNF NNP cord-259669-fod4xkd7 13 2 - - HYPH cord-259669-fod4xkd7 13 3 α α NNP cord-259669-fod4xkd7 13 4 , , , cord-259669-fod4xkd7 13 5 IL-6 IL-6 NNP cord-259669-fod4xkd7 13 6 and and CC cord-259669-fod4xkd7 13 7 IL-12 IL-12 NNP cord-259669-fod4xkd7 13 8 . . . cord-259669-fod4xkd7 14 1 As as IN cord-259669-fod4xkd7 14 2 such such JJ cord-259669-fod4xkd7 14 3 , , , cord-259669-fod4xkd7 14 4 the the DT cord-259669-fod4xkd7 14 5 DC DC NNP cord-259669-fod4xkd7 14 6 family family NN cord-259669-fod4xkd7 14 7 as as IN cord-259669-fod4xkd7 14 8 a a DT cord-259669-fod4xkd7 14 9 whole whole NN cord-259669-fod4xkd7 14 10 is be VBZ cord-259669-fod4xkd7 14 11 a a DT cord-259669-fod4xkd7 14 12 powerful powerful JJ cord-259669-fod4xkd7 14 13 ally ally NN cord-259669-fod4xkd7 14 14 in in IN cord-259669-fod4xkd7 14 15 the the DT cord-259669-fod4xkd7 14 16 host host NN cord-259669-fod4xkd7 14 17 battle battle NN cord-259669-fod4xkd7 14 18 against against IN cord-259669-fod4xkd7 14 19 pathogen pathogen NN cord-259669-fod4xkd7 14 20 attack attack NN cord-259669-fod4xkd7 14 21 . . . cord-259669-fod4xkd7 15 1 Nevertheless nevertheless RB cord-259669-fod4xkd7 15 2 , , , cord-259669-fod4xkd7 15 3 DC DC NNP cord-259669-fod4xkd7 15 4 in in IN cord-259669-fod4xkd7 15 5 particular particular JJ cord-259669-fod4xkd7 15 6 tissue tissue NN cord-259669-fod4xkd7 15 7 environments environment NNS cord-259669-fod4xkd7 15 8 or or CC cord-259669-fod4xkd7 15 9 under under IN cord-259669-fod4xkd7 15 10 particular particular JJ cord-259669-fod4xkd7 15 11 stimuli stimulus NNS cord-259669-fod4xkd7 15 12 can can MD cord-259669-fod4xkd7 15 13 down down RB cord-259669-fod4xkd7 15 14 - - HYPH cord-259669-fod4xkd7 15 15 regulate regulate VB cord-259669-fod4xkd7 15 16 immune immune JJ cord-259669-fod4xkd7 15 17 response response NN cord-259669-fod4xkd7 15 18 development development NN cord-259669-fod4xkd7 15 19 . . . cord-259669-fod4xkd7 16 1 This this DT cord-259669-fod4xkd7 16 2 is be VBZ cord-259669-fod4xkd7 16 3 not not RB cord-259669-fod4xkd7 16 4 only only RB cord-259669-fod4xkd7 16 5 important important JJ cord-259669-fod4xkd7 16 6 for for IN cord-259669-fod4xkd7 16 7 preventing prevent VBG cord-259669-fod4xkd7 16 8 over over IN cord-259669-fod4xkd7 16 9 - - HYPH cord-259669-fod4xkd7 16 10 activation activation NN cord-259669-fod4xkd7 16 11 of of IN cord-259669-fod4xkd7 16 12 the the DT cord-259669-fod4xkd7 16 13 immune immune JJ cord-259669-fod4xkd7 16 14 system system NN cord-259669-fod4xkd7 16 15 and and CC cord-259669-fod4xkd7 16 16 also also RB cord-259669-fod4xkd7 16 17 for for IN cord-259669-fod4xkd7 16 18 ensuring ensure VBG cord-259669-fod4xkd7 16 19 tolerance tolerance NN cord-259669-fod4xkd7 16 20 against against IN cord-259669-fod4xkd7 16 21 self self NN cord-259669-fod4xkd7 16 22 or or CC cord-259669-fod4xkd7 16 23 “ " `` cord-259669-fod4xkd7 16 24 friendly friendly JJ cord-259669-fod4xkd7 16 25 ” " '' cord-259669-fod4xkd7 16 26 substances substance NNS cord-259669-fod4xkd7 16 27 including include VBG cord-259669-fod4xkd7 16 28 food food NN cord-259669-fod4xkd7 16 29 components component NNS cord-259669-fod4xkd7 16 30 , , , cord-259669-fod4xkd7 16 31 but but CC cord-259669-fod4xkd7 16 32 may may MD cord-259669-fod4xkd7 16 33 also also RB cord-259669-fod4xkd7 16 34 be be VB cord-259669-fod4xkd7 16 35 used use VBN cord-259669-fod4xkd7 16 36 as as IN cord-259669-fod4xkd7 16 37 a a DT cord-259669-fod4xkd7 16 38 mechanism mechanism NN cord-259669-fod4xkd7 16 39 of of IN cord-259669-fod4xkd7 16 40 pathogens pathogen NNS cord-259669-fod4xkd7 16 41 to to TO cord-259669-fod4xkd7 16 42 evade evade VB cord-259669-fod4xkd7 16 43 immune immune JJ cord-259669-fod4xkd7 16 44 responses response NNS cord-259669-fod4xkd7 16 45 . . . cord-259669-fod4xkd7 17 1 Dendritic dendritic JJ cord-259669-fod4xkd7 17 2 cells cell NNS cord-259669-fod4xkd7 17 3 ( ( -LRB- cord-259669-fod4xkd7 17 4 DCs DCs NNP cord-259669-fod4xkd7 17 5 ) ) -RRB- cord-259669-fod4xkd7 17 6 are be VBP cord-259669-fod4xkd7 17 7 a a DT cord-259669-fod4xkd7 17 8 heterogeneous heterogeneous JJ cord-259669-fod4xkd7 17 9 group group NN cord-259669-fod4xkd7 17 10 of of IN cord-259669-fod4xkd7 17 11 potent potent JJ cord-259669-fod4xkd7 17 12 antigen antigen NN cord-259669-fod4xkd7 17 13 - - HYPH cord-259669-fod4xkd7 17 14 presenting present VBG cord-259669-fod4xkd7 17 15 cells cell NNS cord-259669-fod4xkd7 17 16 ( ( -LRB- cord-259669-fod4xkd7 17 17 APCs apc NNS cord-259669-fod4xkd7 17 18 ) ) -RRB- cord-259669-fod4xkd7 17 19 with with IN cord-259669-fod4xkd7 17 20 the the DT cord-259669-fod4xkd7 17 21 unique unique JJ cord-259669-fod4xkd7 17 22 capacity capacity NN cord-259669-fod4xkd7 17 23 to to IN cord-259669-fod4xkd7 17 24 prime prime JJ cord-259669-fod4xkd7 17 25 naive naive JJ cord-259669-fod4xkd7 17 26 T t NN cord-259669-fod4xkd7 17 27 - - HYPH cord-259669-fod4xkd7 17 28 cell cell NN cord-259669-fod4xkd7 17 29 responses response NNS cord-259669-fod4xkd7 17 30 [ [ -LRB- cord-259669-fod4xkd7 17 31 1 1 CD cord-259669-fod4xkd7 17 32 ] ] -RRB- cord-259669-fod4xkd7 17 33 . . . cord-259669-fod4xkd7 18 1 In in IN cord-259669-fod4xkd7 18 2 order order NN cord-259669-fod4xkd7 18 3 to to TO cord-259669-fod4xkd7 18 4 fulfil fulfil VB cord-259669-fod4xkd7 18 5 their -PRON- PRP$ cord-259669-fod4xkd7 18 6 role role NN cord-259669-fod4xkd7 18 7 as as IN cord-259669-fod4xkd7 18 8 sentinels sentinel NNS cord-259669-fod4xkd7 18 9 of of IN cord-259669-fod4xkd7 18 10 the the DT cord-259669-fod4xkd7 18 11 immune immune JJ cord-259669-fod4xkd7 18 12 system system NN cord-259669-fod4xkd7 18 13 , , , cord-259669-fod4xkd7 18 14 they -PRON- PRP cord-259669-fod4xkd7 18 15 express express VBP cord-259669-fod4xkd7 18 16 several several JJ cord-259669-fod4xkd7 18 17 families family NNS cord-259669-fod4xkd7 18 18 of of IN cord-259669-fod4xkd7 18 19 specialized specialized JJ cord-259669-fod4xkd7 18 20 pattern pattern NN cord-259669-fod4xkd7 18 21 recognition recognition NN cord-259669-fod4xkd7 18 22 receptors receptor NNS cord-259669-fod4xkd7 18 23 ( ( -LRB- cord-259669-fod4xkd7 18 24 PRRs PRRs NNP cord-259669-fod4xkd7 18 25 ) ) -RRB- cord-259669-fod4xkd7 18 26 for for IN cord-259669-fod4xkd7 18 27 particular particular JJ cord-259669-fod4xkd7 18 28 pathogenassociated pathogenassociated JJ cord-259669-fod4xkd7 18 29 molecular molecular JJ cord-259669-fod4xkd7 18 30 patterns pattern NNS cord-259669-fod4xkd7 18 31 ( ( -LRB- cord-259669-fod4xkd7 18 32 PAMPs pamp NNS cord-259669-fod4xkd7 18 33 ) ) -RRB- cord-259669-fod4xkd7 18 34 . . . cord-259669-fod4xkd7 19 1 These these DT cord-259669-fod4xkd7 19 2 include include VBP cord-259669-fod4xkd7 19 3 Toll toll NN cord-259669-fod4xkd7 19 4 - - HYPH cord-259669-fod4xkd7 19 5 like like JJ cord-259669-fod4xkd7 19 6 receptors receptor NNS cord-259669-fod4xkd7 19 7 ( ( -LRB- cord-259669-fod4xkd7 19 8 TLRs TLRs NNP cord-259669-fod4xkd7 19 9 ) ) -RRB- cord-259669-fod4xkd7 19 10 , , , cord-259669-fod4xkd7 19 11 nucleotide nucleotide NN cord-259669-fod4xkd7 19 12 - - HYPH cord-259669-fod4xkd7 19 13 binding bind VBG cord-259669-fod4xkd7 19 14 oligomerization oligomerization NN cord-259669-fod4xkd7 19 15 domain domain NN cord-259669-fod4xkd7 19 16 ( ( -LRB- cord-259669-fod4xkd7 19 17 NOD)-like nod)-like CD cord-259669-fod4xkd7 19 18 receptors receptor NNS cord-259669-fod4xkd7 19 19 ( ( -LRB- cord-259669-fod4xkd7 19 20 NLRs NLRs NNP cord-259669-fod4xkd7 19 21 ) ) -RRB- cord-259669-fod4xkd7 19 22 , , , cord-259669-fod4xkd7 19 23 retinoic retinoic JJ cord-259669-fod4xkd7 19 24 acid acid NN cord-259669-fod4xkd7 19 25 - - HYPH cord-259669-fod4xkd7 19 26 inducible inducible JJ cord-259669-fod4xkd7 19 27 gene gene NN cord-259669-fod4xkd7 19 28 I i NN cord-259669-fod4xkd7 19 29 ( ( -LRB- cord-259669-fod4xkd7 19 30 RIG rig NN cord-259669-fod4xkd7 19 31 - - HYPH cord-259669-fod4xkd7 19 32 I)like I)like NNP cord-259669-fod4xkd7 19 33 receptors receptor NNS cord-259669-fod4xkd7 19 34 ( ( -LRB- cord-259669-fod4xkd7 19 35 RLRs RLRs NNP cord-259669-fod4xkd7 19 36 ) ) -RRB- cord-259669-fod4xkd7 19 37 and and CC cord-259669-fod4xkd7 19 38 C c NN cord-259669-fod4xkd7 19 39 - - HYPH cord-259669-fod4xkd7 19 40 type type NN cord-259669-fod4xkd7 19 41 lectin lectin NN cord-259669-fod4xkd7 19 42 receptors receptor NNS cord-259669-fod4xkd7 19 43 ( ( -LRB- cord-259669-fod4xkd7 19 44 CLRs CLRs NNP cord-259669-fod4xkd7 19 45 ) ) -RRB- cord-259669-fod4xkd7 19 46 all all DT cord-259669-fod4xkd7 19 47 reacting react VBG cord-259669-fod4xkd7 19 48 directly directly RB cord-259669-fod4xkd7 19 49 with with IN cord-259669-fod4xkd7 19 50 pathogen pathogen NN cord-259669-fod4xkd7 19 51 components component NNS cord-259669-fod4xkd7 19 52 [ [ -LRB- cord-259669-fod4xkd7 19 53 2 2 CD cord-259669-fod4xkd7 19 54 ] ] -RRB- cord-259669-fod4xkd7 19 55 [ [ -LRB- cord-259669-fod4xkd7 19 56 3 3 CD cord-259669-fod4xkd7 19 57 ] ] -RRB- cord-259669-fod4xkd7 19 58 [ [ -LRB- cord-259669-fod4xkd7 19 59 4 4 CD cord-259669-fod4xkd7 19 60 ] ] -RRB- cord-259669-fod4xkd7 19 61 . . . cord-259669-fod4xkd7 20 1 In in IN cord-259669-fod4xkd7 20 2 addition addition NN cord-259669-fod4xkd7 20 3 , , , cord-259669-fod4xkd7 20 4 many many JJ cord-259669-fod4xkd7 20 5 other other JJ cord-259669-fod4xkd7 20 6 receptors receptor NNS cord-259669-fod4xkd7 20 7 exist exist VBP cord-259669-fod4xkd7 20 8 such such JJ cord-259669-fod4xkd7 20 9 as as IN cord-259669-fod4xkd7 20 10 Fc Fc NNP cord-259669-fod4xkd7 20 11 receptors receptor NNS cord-259669-fod4xkd7 20 12 and and CC cord-259669-fod4xkd7 20 13 activated activate VBN cord-259669-fod4xkd7 20 14 complement complement NN cord-259669-fod4xkd7 20 15 component component NN cord-259669-fod4xkd7 20 16 receptors receptor NNS cord-259669-fod4xkd7 20 17 , , , cord-259669-fod4xkd7 20 18 reacting react VBG cord-259669-fod4xkd7 20 19 with with IN cord-259669-fod4xkd7 20 20 complexes complex NNS cord-259669-fod4xkd7 20 21 of of IN cord-259669-fod4xkd7 20 22 pathogen pathogen NN cord-259669-fod4xkd7 20 23 antigen antigen NN cord-259669-fod4xkd7 20 24 with with IN cord-259669-fod4xkd7 20 25 antibody antibody NN cord-259669-fod4xkd7 20 26 or or CC cord-259669-fod4xkd7 20 27 complement complement NN cord-259669-fod4xkd7 20 28 . . . cord-259669-fod4xkd7 21 1 Another another DT cord-259669-fod4xkd7 21 2 element element NN cord-259669-fod4xkd7 21 3 essential essential JJ cord-259669-fod4xkd7 21 4 to to IN cord-259669-fod4xkd7 21 5 DC DC NNP cord-259669-fod4xkd7 21 6 biology biology NN cord-259669-fod4xkd7 21 7 is be VBZ cord-259669-fod4xkd7 21 8 their -PRON- PRP$ cord-259669-fod4xkd7 21 9 migratory migratory JJ cord-259669-fod4xkd7 21 10 behaviour behaviour NN cord-259669-fod4xkd7 21 11 in in IN cord-259669-fod4xkd7 21 12 response response NN cord-259669-fod4xkd7 21 13 to to IN cord-259669-fod4xkd7 21 14 chemokine chemokine NN cord-259669-fod4xkd7 21 15 gradients gradient NNS cord-259669-fod4xkd7 21 16 . . . cord-259669-fod4xkd7 22 1 DCs DCs NNP cord-259669-fod4xkd7 22 2 are be VBP cord-259669-fod4xkd7 22 3 the the DT cord-259669-fod4xkd7 22 4 main main JJ cord-259669-fod4xkd7 22 5 cellular cellular JJ cord-259669-fod4xkd7 22 6 element element NN cord-259669-fod4xkd7 22 7 controlling control VBG cord-259669-fod4xkd7 22 8 T T NNP cord-259669-fod4xkd7 22 9 lymphocyte lymphocyte NN cord-259669-fod4xkd7 22 10 activation activation NN cord-259669-fod4xkd7 22 11 and and CC cord-259669-fod4xkd7 22 12 regulation regulation NN cord-259669-fod4xkd7 22 13 . . . cord-259669-fod4xkd7 23 1 Furthermore furthermore RB cord-259669-fod4xkd7 23 2 , , , cord-259669-fod4xkd7 23 3 they -PRON- PRP cord-259669-fod4xkd7 23 4 are be VBP cord-259669-fod4xkd7 23 5 involved involve VBN cord-259669-fod4xkd7 23 6 in in IN cord-259669-fod4xkd7 23 7 B b NN cord-259669-fod4xkd7 23 8 - - HYPH cord-259669-fod4xkd7 23 9 cell cell NN cord-259669-fod4xkd7 23 10 responses response NNS cord-259669-fod4xkd7 23 11 , , , cord-259669-fod4xkd7 23 12 possibly possibly RB cord-259669-fod4xkd7 23 13 through through IN cord-259669-fod4xkd7 23 14 the the DT cord-259669-fod4xkd7 23 15 delivery delivery NN cord-259669-fod4xkd7 23 16 of of IN cord-259669-fod4xkd7 23 17 native native JJ cord-259669-fod4xkd7 23 18 antigen antigen NN cord-259669-fod4xkd7 23 19 to to IN cord-259669-fod4xkd7 23 20 B b NN cord-259669-fod4xkd7 23 21 lymphocytes lymphocyte NNS cord-259669-fod4xkd7 23 22 [ [ -LRB- cord-259669-fod4xkd7 23 23 5 5 CD cord-259669-fod4xkd7 23 24 ] ] -RRB- cord-259669-fod4xkd7 23 25 [ [ -LRB- cord-259669-fod4xkd7 23 26 6 6 CD cord-259669-fod4xkd7 23 27 ] ] -RRB- cord-259669-fod4xkd7 23 28 [ [ -LRB- cord-259669-fod4xkd7 23 29 7 7 CD cord-259669-fod4xkd7 23 30 ] ] -RRB- cord-259669-fod4xkd7 23 31 , , , cord-259669-fod4xkd7 23 32 but but CC cord-259669-fod4xkd7 23 33 certainly certainly RB cord-259669-fod4xkd7 23 34 through through IN cord-259669-fod4xkd7 23 35 the the DT cord-259669-fod4xkd7 23 36 production production NN cord-259669-fod4xkd7 23 37 of of IN cord-259669-fod4xkd7 23 38 B b NN cord-259669-fod4xkd7 23 39 - - HYPH cord-259669-fod4xkd7 23 40 cell cell NN cord-259669-fod4xkd7 23 41 stimulatory stimulatory JJ cord-259669-fod4xkd7 23 42 factors factor NNS cord-259669-fod4xkd7 23 43 important important JJ cord-259669-fod4xkd7 23 44 for for IN cord-259669-fod4xkd7 23 45 B b NN cord-259669-fod4xkd7 23 46 - - HYPH cord-259669-fod4xkd7 23 47 cell cell NN cord-259669-fod4xkd7 23 48 proliferation proliferation NN cord-259669-fod4xkd7 23 49 , , , cord-259669-fod4xkd7 23 50 differentiation differentiation NN cord-259669-fod4xkd7 23 51 and and CC cord-259669-fod4xkd7 23 52 isotype isotype NN cord-259669-fod4xkd7 23 53 switching switch VBG cord-259669-fod4xkd7 23 54 [ [ -LRB- cord-259669-fod4xkd7 23 55 8 8 CD cord-259669-fod4xkd7 23 56 , , , cord-259669-fod4xkd7 23 57 9 9 CD cord-259669-fod4xkd7 23 58 ] ] -RRB- cord-259669-fod4xkd7 23 59 . . . cord-259669-fod4xkd7 24 1 DCs DCs NNP cord-259669-fod4xkd7 24 2 also also RB cord-259669-fod4xkd7 24 3 play play VBP cord-259669-fod4xkd7 24 4 a a DT cord-259669-fod4xkd7 24 5 functional functional JJ cord-259669-fod4xkd7 24 6 role role NN cord-259669-fod4xkd7 24 7 for for IN cord-259669-fod4xkd7 24 8 NK NK NNP cord-259669-fod4xkd7 24 9 cell cell NN cord-259669-fod4xkd7 24 10 activation activation NN cord-259669-fod4xkd7 24 11 [ [ -LRB- cord-259669-fod4xkd7 24 12 10 10 CD cord-259669-fod4xkd7 24 13 , , , cord-259669-fod4xkd7 24 14 11 11 CD cord-259669-fod4xkd7 24 15 ] ] -RRB- cord-259669-fod4xkd7 24 16 , , , cord-259669-fod4xkd7 24 17 and and CC cord-259669-fod4xkd7 24 18 are be VBP cord-259669-fod4xkd7 24 19 in in IN cord-259669-fod4xkd7 24 20 a a DT cord-259669-fod4xkd7 24 21 two two CD cord-259669-fod4xkd7 24 22 - - HYPH cord-259669-fod4xkd7 24 23 way way NN cord-259669-fod4xkd7 24 24 communication communication NN cord-259669-fod4xkd7 24 25 with with IN cord-259669-fod4xkd7 24 26 neutrophils neutrophil NNS cord-259669-fod4xkd7 24 27 [ [ -LRB- cord-259669-fod4xkd7 24 28 12 12 CD cord-259669-fod4xkd7 24 29 ] ] -RRB- cord-259669-fod4xkd7 24 30 . . . cord-259669-fod4xkd7 25 1 Understanding understand VBG cord-259669-fod4xkd7 25 2 DC DC NNP cord-259669-fod4xkd7 25 3 biology biology NN cord-259669-fod4xkd7 25 4 requires require VBZ cord-259669-fod4xkd7 25 5 the the DT cord-259669-fod4xkd7 25 6 consideration consideration NN cord-259669-fod4xkd7 25 7 of of IN cord-259669-fod4xkd7 25 8 the the DT cord-259669-fod4xkd7 25 9 heterogeneity heterogeneity NN cord-259669-fod4xkd7 25 10 and and CC cord-259669-fod4xkd7 25 11 independence independence NN cord-259669-fod4xkd7 25 12 of of IN cord-259669-fod4xkd7 25 13 DC DC NNP cord-259669-fod4xkd7 25 14 functional functional JJ cord-259669-fod4xkd7 25 15 plasticity plasticity NN cord-259669-fod4xkd7 25 16 . . . cord-259669-fod4xkd7 26 1 An an DT cord-259669-fod4xkd7 26 2 important important JJ cord-259669-fod4xkd7 26 3 element element NN cord-259669-fod4xkd7 26 4 therein therein RB cord-259669-fod4xkd7 26 5 is be VBZ cord-259669-fod4xkd7 26 6 the the DT cord-259669-fod4xkd7 26 7 functional functional JJ cord-259669-fod4xkd7 26 8 and and CC cord-259669-fod4xkd7 26 9 phenotypic phenotypic JJ cord-259669-fod4xkd7 26 10 differentiation differentiation NN cord-259669-fod4xkd7 26 11 of of IN cord-259669-fod4xkd7 26 12 ' ' '' cord-259669-fod4xkd7 26 13 ' ' '' cord-259669-fod4xkd7 26 14 conventional conventional JJ cord-259669-fod4xkd7 26 15 DC DC NNP cord-259669-fod4xkd7 26 16 ' ' '' cord-259669-fod4xkd7 26 17 ' ' '' cord-259669-fod4xkd7 26 18 ( ( -LRB- cord-259669-fod4xkd7 26 19 cDC cDC NNP cord-259669-fod4xkd7 26 20 ) ) -RRB- cord-259669-fod4xkd7 26 21 from from IN cord-259669-fod4xkd7 26 22 ' ' `` cord-259669-fod4xkd7 26 23 ' ' `` cord-259669-fod4xkd7 26 24 plasmacytoid plasmacytoid NNP cord-259669-fod4xkd7 26 25 DC DC NNP cord-259669-fod4xkd7 26 26 ' ' '' cord-259669-fod4xkd7 26 27 ' ' '' cord-259669-fod4xkd7 26 28 ( ( -LRB- cord-259669-fod4xkd7 26 29 pDC pDC NNP cord-259669-fod4xkd7 26 30 ) ) -RRB- cord-259669-fod4xkd7 26 31 . . . cord-259669-fod4xkd7 27 1 The the DT cord-259669-fod4xkd7 27 2 term term NN cord-259669-fod4xkd7 27 3 cDC cDC NNP cord-259669-fod4xkd7 27 4 summarizes summarize VBZ cord-259669-fod4xkd7 27 5 all all DT cord-259669-fod4xkd7 27 6 DC DC NNP cord-259669-fod4xkd7 27 7 subsets subset NNS cord-259669-fod4xkd7 27 8 with with IN cord-259669-fod4xkd7 27 9 ' ' '' cord-259669-fod4xkd7 27 10 ' ' '' cord-259669-fod4xkd7 27 11 professional professional JJ cord-259669-fod4xkd7 27 12 antigen antigen NN cord-259669-fod4xkd7 27 13 presenting present VBG cord-259669-fod4xkd7 27 14 ' ' '' cord-259669-fod4xkd7 27 15 ' ' '' cord-259669-fod4xkd7 27 16 function function NN cord-259669-fod4xkd7 27 17 , , , cord-259669-fod4xkd7 27 18 while while IN cord-259669-fod4xkd7 27 19 pDC pDC NNP cord-259669-fod4xkd7 27 20 represent represent VB cord-259669-fod4xkd7 27 21 the the DT cord-259669-fod4xkd7 27 22 ' ' `` cord-259669-fod4xkd7 27 23 ' ' `` cord-259669-fod4xkd7 27 24 professional professional JJ cord-259669-fod4xkd7 27 25 interferon interferon NN cord-259669-fod4xkd7 27 26 - - : cord-259669-fod4xkd7 27 27 a a DT cord-259669-fod4xkd7 27 28 producers producer NNS cord-259669-fod4xkd7 27 29 ' ' POS cord-259669-fod4xkd7 27 30 ' ' '' cord-259669-fod4xkd7 27 31 [ [ -LRB- cord-259669-fod4xkd7 27 32 13 13 CD cord-259669-fod4xkd7 27 33 ] ] -RRB- cord-259669-fod4xkd7 27 34 . . . cord-259669-fod4xkd7 28 1 Indeed indeed RB cord-259669-fod4xkd7 28 2 , , , cord-259669-fod4xkd7 28 3 pDC pDC NNP cord-259669-fod4xkd7 28 4 are be VBP cord-259669-fod4xkd7 28 5 also also RB cord-259669-fod4xkd7 28 6 referred refer VBN cord-259669-fod4xkd7 28 7 to to IN cord-259669-fod4xkd7 28 8 as as IN cord-259669-fod4xkd7 28 9 ' ' '' cord-259669-fod4xkd7 28 10 ' ' '' cord-259669-fod4xkd7 28 11 natural natural JJ cord-259669-fod4xkd7 28 12 interferon interferon NN cord-259669-fod4xkd7 28 13 producing produce VBG cord-259669-fod4xkd7 28 14 cells cell NNS cord-259669-fod4xkd7 28 15 ' ' '' cord-259669-fod4xkd7 28 16 ' ' '' cord-259669-fod4xkd7 29 1 ( ( -LRB- cord-259669-fod4xkd7 29 2 NIPC NIPC NNP cord-259669-fod4xkd7 29 3 ) ) -RRB- cord-259669-fod4xkd7 30 1 , , , cord-259669-fod4xkd7 30 2 a a DT cord-259669-fod4xkd7 30 3 functional functional JJ cord-259669-fod4xkd7 30 4 entity entity NN cord-259669-fod4xkd7 30 5 first first RB cord-259669-fod4xkd7 30 6 described describe VBN cord-259669-fod4xkd7 30 7 25 25 CD cord-259669-fod4xkd7 30 8 years year NNS cord-259669-fod4xkd7 30 9 ago ago RB cord-259669-fod4xkd7 30 10 [ [ -LRB- cord-259669-fod4xkd7 30 11 14 14 CD cord-259669-fod4xkd7 30 12 ] ] -RRB- cord-259669-fod4xkd7 30 13 . . . cord-259669-fod4xkd7 31 1 However however RB cord-259669-fod4xkd7 31 2 , , , cord-259669-fod4xkd7 31 3 more more JJR cord-259669-fod4xkd7 31 4 recent recent JJ cord-259669-fod4xkd7 31 5 studies study NNS cord-259669-fod4xkd7 31 6 have have VBP cord-259669-fod4xkd7 31 7 demonstrated demonstrate VBN cord-259669-fod4xkd7 31 8 that that IN cord-259669-fod4xkd7 31 9 also also RB cord-259669-fod4xkd7 31 10 pDC pDC NNP cord-259669-fod4xkd7 31 11 have have VBP cord-259669-fod4xkd7 31 12 important important JJ cord-259669-fod4xkd7 31 13 antigen antigen NN cord-259669-fod4xkd7 31 14 - - HYPH cord-259669-fod4xkd7 31 15 presenting present VBG cord-259669-fod4xkd7 31 16 functions function NNS cord-259669-fod4xkd7 31 17 and and CC cord-259669-fod4xkd7 31 18 that that IN cord-259669-fod4xkd7 31 19 the the DT cord-259669-fod4xkd7 31 20 two two CD cord-259669-fod4xkd7 31 21 DC DC NNP cord-259669-fod4xkd7 31 22 subsets subset NNS cord-259669-fod4xkd7 31 23 complement complement VBP cord-259669-fod4xkd7 31 24 each each DT cord-259669-fod4xkd7 31 25 others other NNS cord-259669-fod4xkd7 31 26 by by IN cord-259669-fod4xkd7 31 27 having have VBG cord-259669-fod4xkd7 31 28 a a DT cord-259669-fod4xkd7 31 29 distinct distinct JJ cord-259669-fod4xkd7 31 30 regulation regulation NN cord-259669-fod4xkd7 31 31 of of IN cord-259669-fod4xkd7 31 32 MHC MHC NNP cord-259669-fod4xkd7 31 33 class class NN cord-259669-fod4xkd7 31 34 I I NNP cord-259669-fod4xkd7 31 35 - - HYPH cord-259669-fod4xkd7 31 36 and and CC cord-259669-fod4xkd7 31 37 II II NNP cord-259669-fod4xkd7 31 38 - - HYPH cord-259669-fod4xkd7 31 39 dependent dependent JJ cord-259669-fod4xkd7 31 40 antigen antigen NN cord-259669-fod4xkd7 31 41 presentation presentation NN cord-259669-fod4xkd7 31 42 [ [ -LRB- cord-259669-fod4xkd7 31 43 15 15 CD cord-259669-fod4xkd7 31 44 ] ] -RRB- cord-259669-fod4xkd7 31 45 [ [ -LRB- cord-259669-fod4xkd7 31 46 16 16 CD cord-259669-fod4xkd7 31 47 ] ] -RRB- cord-259669-fod4xkd7 31 48 [ [ -LRB- cord-259669-fod4xkd7 31 49 17 17 CD cord-259669-fod4xkd7 31 50 ] ] -RRB- cord-259669-fod4xkd7 31 51 . . . cord-259669-fod4xkd7 32 1 Furthermore furthermore RB cord-259669-fod4xkd7 32 2 , , , cord-259669-fod4xkd7 32 3 DCs DCs NNP cord-259669-fod4xkd7 32 4 show show VBP cord-259669-fod4xkd7 32 5 a a DT cord-259669-fod4xkd7 32 6 high high JJ cord-259669-fod4xkd7 32 7 level level NN cord-259669-fod4xkd7 32 8 of of IN cord-259669-fod4xkd7 32 9 heterogeneity heterogeneity NN cord-259669-fod4xkd7 32 10 , , , cord-259669-fod4xkd7 32 11 particularly particularly RB cord-259669-fod4xkd7 32 12 in in IN cord-259669-fod4xkd7 32 13 the the DT cord-259669-fod4xkd7 32 14 specialized specialized JJ cord-259669-fod4xkd7 32 15 roles role NNS cord-259669-fod4xkd7 32 16 of of IN cord-259669-fod4xkd7 32 17 various various JJ cord-259669-fod4xkd7 32 18 DC DC NNP cord-259669-fod4xkd7 32 19 subsets subset NNS cord-259669-fod4xkd7 32 20 dependent dependent JJ cord-259669-fod4xkd7 32 21 on on IN cord-259669-fod4xkd7 32 22 their -PRON- PRP$ cord-259669-fod4xkd7 32 23 tissue tissue NN cord-259669-fod4xkd7 32 24 localization localization NN cord-259669-fod4xkd7 32 25 and and CC cord-259669-fod4xkd7 32 26 local local JJ cord-259669-fod4xkd7 32 27 immunological immunological JJ cord-259669-fod4xkd7 32 28 environment environment NN cord-259669-fod4xkd7 32 29 , , , cord-259669-fod4xkd7 32 30 which which WDT cord-259669-fod4xkd7 32 31 guides guide VBZ cord-259669-fod4xkd7 32 32 their -PRON- PRP$ cord-259669-fod4xkd7 32 33 function function NN cord-259669-fod4xkd7 32 34 ( ( -LRB- cord-259669-fod4xkd7 32 35 Table table NN cord-259669-fod4xkd7 32 36 1 1 CD cord-259669-fod4xkd7 32 37 ) ) -RRB- cord-259669-fod4xkd7 32 38 . . . cord-259669-fod4xkd7 33 1 One one CD cord-259669-fod4xkd7 33 2 general general JJ cord-259669-fod4xkd7 33 3 functional functional JJ cord-259669-fod4xkd7 33 4 consideration consideration NN cord-259669-fod4xkd7 33 5 of of IN cord-259669-fod4xkd7 33 6 all all DT cord-259669-fod4xkd7 33 7 DC DC NNP cord-259669-fod4xkd7 33 8 subsets subset NNS cord-259669-fod4xkd7 33 9 is be VBZ cord-259669-fod4xkd7 33 10 their -PRON- PRP$ cord-259669-fod4xkd7 33 11 critical critical JJ cord-259669-fod4xkd7 33 12 roles role NNS cord-259669-fod4xkd7 33 13 as as IN cord-259669-fod4xkd7 33 14 immunological immunological JJ cord-259669-fod4xkd7 33 15 sentinels sentinel NNS cord-259669-fod4xkd7 33 16 . . . cord-259669-fod4xkd7 34 1 Being be VBG cord-259669-fod4xkd7 34 2 strategically strategically RB cord-259669-fod4xkd7 34 3 located locate VBN cord-259669-fod4xkd7 34 4 at at IN cord-259669-fod4xkd7 34 5 sites site NNS cord-259669-fod4xkd7 34 6 of of IN cord-259669-fod4xkd7 34 7 pathogen pathogen NN cord-259669-fod4xkd7 34 8 entry entry NN cord-259669-fod4xkd7 34 9 , , , cord-259669-fod4xkd7 34 10 such such JJ cord-259669-fod4xkd7 34 11 as as IN cord-259669-fod4xkd7 34 12 mucosal mucosal JJ cord-259669-fod4xkd7 34 13 surfaces surface NNS cord-259669-fod4xkd7 34 14 and and CC cord-259669-fod4xkd7 34 15 Considering consider VBG cord-259669-fod4xkd7 34 16 the the DT cord-259669-fod4xkd7 34 17 pivotal pivotal JJ cord-259669-fod4xkd7 34 18 roles role NNS cord-259669-fod4xkd7 34 19 played play VBN cord-259669-fod4xkd7 34 20 by by IN cord-259669-fod4xkd7 34 21 dendritic dendritic JJ cord-259669-fod4xkd7 34 22 cells cell NNS cord-259669-fod4xkd7 34 23 ( ( -LRB- cord-259669-fod4xkd7 34 24 DCs DCs NNP cord-259669-fod4xkd7 34 25 ) ) -RRB- cord-259669-fod4xkd7 34 26 in in IN cord-259669-fod4xkd7 34 27 both both DT cord-259669-fod4xkd7 34 28 innate innate JJ cord-259669-fod4xkd7 34 29 and and CC cord-259669-fod4xkd7 34 30 adaptive adaptive JJ cord-259669-fod4xkd7 34 31 immune immune JJ cord-259669-fod4xkd7 34 32 responses response NNS cord-259669-fod4xkd7 34 33 , , , cord-259669-fod4xkd7 34 34 advances advance VBZ cord-259669-fod4xkd7 34 35 in in IN cord-259669-fod4xkd7 34 36 the the DT cord-259669-fod4xkd7 34 37 field field NN cord-259669-fod4xkd7 34 38 of of IN cord-259669-fod4xkd7 34 39 porcine porcine JJ cord-259669-fod4xkd7 34 40 immunology immunology NN cord-259669-fod4xkd7 34 41 DC DC NNP cord-259669-fod4xkd7 34 42 biology biology NN cord-259669-fod4xkd7 34 43 have have VBP cord-259669-fod4xkd7 34 44 recently recently RB cord-259669-fod4xkd7 34 45 progressed progress VBN cord-259669-fod4xkd7 34 46 rapidly rapidly RB cord-259669-fod4xkd7 34 47 . . . cord-259669-fod4xkd7 35 1 As as IN cord-259669-fod4xkd7 35 2 with with IN cord-259669-fod4xkd7 35 3 the the DT cord-259669-fod4xkd7 35 4 more more RBR cord-259669-fod4xkd7 35 5 extensively extensively RB cord-259669-fod4xkd7 35 6 studied study VBN cord-259669-fod4xkd7 35 7 murine murine JJ cord-259669-fod4xkd7 35 8 and and CC cord-259669-fod4xkd7 35 9 human human JJ cord-259669-fod4xkd7 35 10 DCs dc NNS cord-259669-fod4xkd7 35 11 , , , cord-259669-fod4xkd7 35 12 porcine porcine JJ cord-259669-fod4xkd7 35 13 DC DC NNP cord-259669-fod4xkd7 35 14 can can MD cord-259669-fod4xkd7 35 15 be be VB cord-259669-fod4xkd7 35 16 generated generate VBN cord-259669-fod4xkd7 35 17 from from IN cord-259669-fod4xkd7 35 18 bone bone NN cord-259669-fod4xkd7 35 19 marrow marrow NN cord-259669-fod4xkd7 35 20 haematopoietic haematopoietic JJ cord-259669-fod4xkd7 35 21 cells cell NNS cord-259669-fod4xkd7 35 22 or or CC cord-259669-fod4xkd7 35 23 monocytes monocyte NNS cord-259669-fod4xkd7 35 24 , , , cord-259669-fod4xkd7 35 25 and and CC cord-259669-fod4xkd7 35 26 have have VBP cord-259669-fod4xkd7 35 27 been be VBN cord-259669-fod4xkd7 35 28 analysed analyse VBN cord-259669-fod4xkd7 35 29 in in IN cord-259669-fod4xkd7 35 30 various various JJ cord-259669-fod4xkd7 35 31 immunological immunological JJ cord-259669-fod4xkd7 35 32 and and CC cord-259669-fod4xkd7 35 33 nonimmunological nonimmunological JJ cord-259669-fod4xkd7 35 34 tissues tissue NNS cord-259669-fod4xkd7 35 35 . . . cord-259669-fod4xkd7 36 1 Both both DT cord-259669-fod4xkd7 36 2 conventional conventional JJ cord-259669-fod4xkd7 36 3 DC DC NNP cord-259669-fod4xkd7 36 4 ( ( -LRB- cord-259669-fod4xkd7 36 5 cDC cDC NNP cord-259669-fod4xkd7 36 6 ) ) -RRB- cord-259669-fod4xkd7 36 7 and and CC cord-259669-fod4xkd7 36 8 plasmacytoid plasmacytoid NNP cord-259669-fod4xkd7 36 9 DC DC NNP cord-259669-fod4xkd7 36 10 ( ( -LRB- cord-259669-fod4xkd7 36 11 pDC pDC NNP cord-259669-fod4xkd7 36 12 ) ) -RRB- cord-259669-fod4xkd7 36 13 have have VBP cord-259669-fod4xkd7 36 14 been be VBN cord-259669-fod4xkd7 36 15 characterized characterize VBN cord-259669-fod4xkd7 36 16 . . . cord-259669-fod4xkd7 37 1 The the DT cord-259669-fod4xkd7 37 2 function function NN cord-259669-fod4xkd7 37 3 of of IN cord-259669-fod4xkd7 37 4 porcine porcine JJ cord-259669-fod4xkd7 37 5 monocyte monocyte NNP cord-259669-fod4xkd7 37 6 - - HYPH cord-259669-fod4xkd7 37 7 derived derive VBN cord-259669-fod4xkd7 37 8 DC DC NNP cord-259669-fod4xkd7 37 9 has have VBZ cord-259669-fod4xkd7 37 10 not not RB cord-259669-fod4xkd7 37 11 only only RB cord-259669-fod4xkd7 37 12 been be VBN cord-259669-fod4xkd7 37 13 characterized characterize VBN cord-259669-fod4xkd7 37 14 in in IN cord-259669-fod4xkd7 37 15 terms term NNS cord-259669-fod4xkd7 37 16 of of IN cord-259669-fod4xkd7 37 17 antigen antigen NN cord-259669-fod4xkd7 37 18 presentation presentation NN cord-259669-fod4xkd7 37 19 and and CC cord-259669-fod4xkd7 37 20 lymphocyte lymphocyte NN cord-259669-fod4xkd7 37 21 activation activation NN cord-259669-fod4xkd7 37 22 , , , cord-259669-fod4xkd7 37 23 but but CC cord-259669-fod4xkd7 37 24 also also RB cord-259669-fod4xkd7 37 25 their -PRON- PRP$ cord-259669-fod4xkd7 37 26 response response NN cord-259669-fod4xkd7 37 27 to to IN cord-259669-fod4xkd7 37 28 various various JJ cord-259669-fod4xkd7 37 29 ligands ligand NNS cord-259669-fod4xkd7 37 30 of of IN cord-259669-fod4xkd7 37 31 pattern pattern NN cord-259669-fod4xkd7 37 32 recognition recognition NN cord-259669-fod4xkd7 37 33 receptors receptor NNS cord-259669-fod4xkd7 37 34 . . . cord-259669-fod4xkd7 38 1 These these DT cord-259669-fod4xkd7 38 2 have have VBP cord-259669-fod4xkd7 38 3 been be VBN cord-259669-fod4xkd7 38 4 characterized characterize VBN cord-259669-fod4xkd7 38 5 in in IN cord-259669-fod4xkd7 38 6 terms term NNS cord-259669-fod4xkd7 38 7 of of IN cord-259669-fod4xkd7 38 8 the the DT cord-259669-fod4xkd7 38 9 induction induction NN cord-259669-fod4xkd7 38 10 of of IN cord-259669-fod4xkd7 38 11 DC DC NNP cord-259669-fod4xkd7 38 12 maturation maturation NN cord-259669-fod4xkd7 38 13 and and CC cord-259669-fod4xkd7 38 14 proinflammatory proinflammatory JJ cord-259669-fod4xkd7 38 15 , , , cord-259669-fod4xkd7 38 16 Th1-like th1-like JJ cord-259669-fod4xkd7 38 17 or or CC cord-259669-fod4xkd7 38 18 Th2-like th2-like JJ cord-259669-fod4xkd7 38 19 cytokines cytokine NNS cord-259669-fod4xkd7 38 20 secretion secretion NN cord-259669-fod4xkd7 38 21 . . . cord-259669-fod4xkd7 39 1 Porcine Porcine NNP cord-259669-fod4xkd7 39 2 pDC pDC NNP cord-259669-fod4xkd7 39 3 most most RBS cord-259669-fod4xkd7 39 4 effectively effectively RB cord-259669-fod4xkd7 39 5 sense sense VBP cord-259669-fod4xkd7 39 6 virus virus NN cord-259669-fod4xkd7 39 7 infections infection NNS cord-259669-fod4xkd7 39 8 and and CC cord-259669-fod4xkd7 39 9 are be VBP cord-259669-fod4xkd7 39 10 characterized characterize VBN cord-259669-fod4xkd7 39 11 by by IN cord-259669-fod4xkd7 39 12 their -PRON- PRP$ cord-259669-fod4xkd7 39 13 capacity capacity NN cord-259669-fod4xkd7 39 14 to to TO cord-259669-fod4xkd7 39 15 produce produce VB cord-259669-fod4xkd7 39 16 large large JJ cord-259669-fod4xkd7 39 17 quantities quantity NNS cord-259669-fod4xkd7 39 18 of of IN cord-259669-fod4xkd7 39 19 IFN IFN NNP cord-259669-fod4xkd7 39 20 - - : cord-259669-fod4xkd7 39 21 a a NNP cord-259669-fod4xkd7 39 22 and and CC cord-259669-fod4xkd7 39 23 the the DT cord-259669-fod4xkd7 39 24 proinflammatory proinflammatory JJ cord-259669-fod4xkd7 39 25 cytokines cytokine NNS cord-259669-fod4xkd7 39 26 TNF TNF NNP cord-259669-fod4xkd7 39 27 - - : cord-259669-fod4xkd7 39 28 a a NNP cord-259669-fod4xkd7 39 29 , , , cord-259669-fod4xkd7 39 30 IL-6 IL-6 NNP cord-259669-fod4xkd7 39 31 and and CC cord-259669-fod4xkd7 39 32 IL-12 IL-12 NNP cord-259669-fod4xkd7 39 33 . . . cord-259669-fod4xkd7 40 1 As as IN cord-259669-fod4xkd7 40 2 such such JJ cord-259669-fod4xkd7 40 3 , , , cord-259669-fod4xkd7 40 4 the the DT cord-259669-fod4xkd7 40 5 DC DC NNP cord-259669-fod4xkd7 40 6 family family NN cord-259669-fod4xkd7 40 7 as as IN cord-259669-fod4xkd7 40 8 a a DT cord-259669-fod4xkd7 40 9 whole whole NN cord-259669-fod4xkd7 40 10 is be VBZ cord-259669-fod4xkd7 40 11 a a DT cord-259669-fod4xkd7 40 12 powerful powerful JJ cord-259669-fod4xkd7 40 13 ally ally NN cord-259669-fod4xkd7 40 14 in in IN cord-259669-fod4xkd7 40 15 the the DT cord-259669-fod4xkd7 40 16 host host NN cord-259669-fod4xkd7 40 17 battle battle NN cord-259669-fod4xkd7 40 18 against against IN cord-259669-fod4xkd7 40 19 pathogen pathogen NN cord-259669-fod4xkd7 40 20 attack attack NN cord-259669-fod4xkd7 40 21 . . . cord-259669-fod4xkd7 41 1 Nevertheless nevertheless RB cord-259669-fod4xkd7 41 2 , , , cord-259669-fod4xkd7 41 3 DC DC NNP cord-259669-fod4xkd7 41 4 in in IN cord-259669-fod4xkd7 41 5 particular particular JJ cord-259669-fod4xkd7 41 6 tissue tissue NN cord-259669-fod4xkd7 41 7 environments environment NNS cord-259669-fod4xkd7 41 8 or or CC cord-259669-fod4xkd7 41 9 under under IN cord-259669-fod4xkd7 41 10 particular particular JJ cord-259669-fod4xkd7 41 11 stimuli stimulus NNS cord-259669-fod4xkd7 41 12 can can MD cord-259669-fod4xkd7 41 13 down down RB cord-259669-fod4xkd7 41 14 - - HYPH cord-259669-fod4xkd7 41 15 regulate regulate VB cord-259669-fod4xkd7 41 16 immune immune JJ cord-259669-fod4xkd7 41 17 response response NN cord-259669-fod4xkd7 41 18 development development NN cord-259669-fod4xkd7 41 19 . . . cord-259669-fod4xkd7 42 1 This this DT cord-259669-fod4xkd7 42 2 is be VBZ cord-259669-fod4xkd7 42 3 not not RB cord-259669-fod4xkd7 42 4 only only RB cord-259669-fod4xkd7 42 5 important important JJ cord-259669-fod4xkd7 42 6 for for IN cord-259669-fod4xkd7 42 7 preventing prevent VBG cord-259669-fod4xkd7 42 8 over over IN cord-259669-fod4xkd7 42 9 - - HYPH cord-259669-fod4xkd7 42 10 activation activation NN cord-259669-fod4xkd7 42 11 of of IN cord-259669-fod4xkd7 42 12 the the DT cord-259669-fod4xkd7 42 13 immune immune JJ cord-259669-fod4xkd7 42 14 system system NN cord-259669-fod4xkd7 42 15 and and CC cord-259669-fod4xkd7 42 16 also also RB cord-259669-fod4xkd7 42 17 for for IN cord-259669-fod4xkd7 42 18 ensuring ensure VBG cord-259669-fod4xkd7 42 19 tolerance tolerance NN cord-259669-fod4xkd7 42 20 against against IN cord-259669-fod4xkd7 42 21 self self NN cord-259669-fod4xkd7 42 22 or or CC cord-259669-fod4xkd7 42 23 ' ' `` cord-259669-fod4xkd7 42 24 ' ' `` cord-259669-fod4xkd7 42 25 friendly friendly JJ cord-259669-fod4xkd7 42 26 ' ' '' cord-259669-fod4xkd7 42 27 ' ' '' cord-259669-fod4xkd7 42 28 substances substance NNS cord-259669-fod4xkd7 42 29 including include VBG cord-259669-fod4xkd7 42 30 food food NN cord-259669-fod4xkd7 42 31 components component NNS cord-259669-fod4xkd7 42 32 , , , cord-259669-fod4xkd7 42 33 but but CC cord-259669-fod4xkd7 42 34 may may MD cord-259669-fod4xkd7 42 35 also also RB cord-259669-fod4xkd7 42 36 be be VB cord-259669-fod4xkd7 42 37 used use VBN cord-259669-fod4xkd7 42 38 as as IN cord-259669-fod4xkd7 42 39 a a DT cord-259669-fod4xkd7 42 40 mechanism mechanism NN cord-259669-fod4xkd7 42 41 of of IN cord-259669-fod4xkd7 42 42 pathogens pathogen NNS cord-259669-fod4xkd7 42 43 to to TO cord-259669-fod4xkd7 42 44 evade evade VB cord-259669-fod4xkd7 42 45 immune immune JJ cord-259669-fod4xkd7 42 46 responses response NNS cord-259669-fod4xkd7 42 47 . . . cord-259669-fod4xkd7 43 1 ß ß NN cord-259669-fod4xkd7 44 1 2008 2008 CD cord-259669-fod4xkd7 44 2 Elsevier Elsevier NNP cord-259669-fod4xkd7 44 3 Ltd. Ltd. NNP cord-259669-fod4xkd7 44 4 All all DT cord-259669-fod4xkd7 44 5 rights right NNS cord-259669-fod4xkd7 44 6 reserved reserve VBN cord-259669-fod4xkd7 44 7 . . . cord-259669-fod4xkd7 45 1 dermal dermal JJ cord-259669-fod4xkd7 45 2 layers layer NNS cord-259669-fod4xkd7 45 3 , , , cord-259669-fod4xkd7 45 4 DC DC NNP cord-259669-fod4xkd7 45 5 can can MD cord-259669-fod4xkd7 45 6 rapidly rapidly RB cord-259669-fod4xkd7 45 7 interact interact VB cord-259669-fod4xkd7 45 8 with with IN cord-259669-fod4xkd7 45 9 pathogen pathogen NN cord-259669-fod4xkd7 45 10 PAMPs pamp NNS cord-259669-fod4xkd7 45 11 resulting result VBG cord-259669-fod4xkd7 45 12 in in IN cord-259669-fod4xkd7 45 13 cell cell NN cord-259669-fod4xkd7 45 14 activation activation NN cord-259669-fod4xkd7 45 15 , , , cord-259669-fod4xkd7 45 16 pathogen pathogen NN cord-259669-fod4xkd7 45 17 uptake uptake NN cord-259669-fod4xkd7 45 18 and and CC cord-259669-fod4xkd7 45 19 degradative degradative JJ cord-259669-fod4xkd7 45 20 processing processing NN cord-259669-fod4xkd7 45 21 of of IN cord-259669-fod4xkd7 45 22 the the DT cord-259669-fod4xkd7 45 23 pathogen pathogen NN cord-259669-fod4xkd7 45 24 ( ( -LRB- cord-259669-fod4xkd7 45 25 antigen antigen NNP cord-259669-fod4xkd7 45 26 ) ) -RRB- cord-259669-fod4xkd7 45 27 . . . cord-259669-fod4xkd7 46 1 A a DT cord-259669-fod4xkd7 46 2 critical critical JJ cord-259669-fod4xkd7 46 3 element element NN cord-259669-fod4xkd7 46 4 therein therein RB cord-259669-fod4xkd7 46 5 is be VBZ cord-259669-fod4xkd7 46 6 the the DT cord-259669-fod4xkd7 46 7 concomitant concomitant JJ cord-259669-fod4xkd7 46 8 uptake uptake NN cord-259669-fod4xkd7 46 9 of of IN cord-259669-fod4xkd7 46 10 antigen antigen NN cord-259669-fod4xkd7 46 11 with with IN cord-259669-fod4xkd7 46 12 PAMP PAMP NNP cord-259669-fod4xkd7 46 13 recognition recognition NN cord-259669-fod4xkd7 46 14 . . . cord-259669-fod4xkd7 47 1 The the DT cord-259669-fod4xkd7 47 2 latter latter JJ cord-259669-fod4xkd7 47 3 represents represent VBZ cord-259669-fod4xkd7 47 4 the the DT cord-259669-fod4xkd7 47 5 ' ' `` cord-259669-fod4xkd7 47 6 ' ' `` cord-259669-fod4xkd7 47 7 danger danger NN cord-259669-fod4xkd7 47 8 ' ' '' cord-259669-fod4xkd7 47 9 ' ' '' cord-259669-fod4xkd7 47 10 signalling signalling NN cord-259669-fod4xkd7 47 11 which which WDT cord-259669-fod4xkd7 47 12 the the DT cord-259669-fod4xkd7 47 13 DC DC NNP cord-259669-fod4xkd7 47 14 requires require VBZ cord-259669-fod4xkd7 47 15 to to TO cord-259669-fod4xkd7 47 16 be be VB cord-259669-fod4xkd7 47 17 activated activate VBN cord-259669-fod4xkd7 47 18 . . . cord-259669-fod4xkd7 48 1 In in IN cord-259669-fod4xkd7 48 2 the the DT cord-259669-fod4xkd7 48 3 absence absence NN cord-259669-fod4xkd7 48 4 of of IN cord-259669-fod4xkd7 48 5 the the DT cord-259669-fod4xkd7 48 6 ' ' `` cord-259669-fod4xkd7 48 7 ' ' `` cord-259669-fod4xkd7 48 8 danger danger NN cord-259669-fod4xkd7 48 9 ' ' '' cord-259669-fod4xkd7 48 10 ' ' '' cord-259669-fod4xkd7 48 11 signal signal NN cord-259669-fod4xkd7 48 12 , , , cord-259669-fod4xkd7 48 13 the the DT cord-259669-fod4xkd7 48 14 DCs dc NNS cord-259669-fod4xkd7 48 15 tend tend VBP cord-259669-fod4xkd7 48 16 to to TO cord-259669-fod4xkd7 48 17 function function VB cord-259669-fod4xkd7 48 18 more more RBR cord-259669-fod4xkd7 48 19 as as IN cord-259669-fod4xkd7 48 20 tolerogenic tolerogenic JJ cord-259669-fod4xkd7 48 21 DC DC NNP cord-259669-fod4xkd7 48 22 , , , cord-259669-fod4xkd7 48 23 inducing induce VBG cord-259669-fod4xkd7 48 24 lymphocyte lymphocyte NN cord-259669-fod4xkd7 48 25 anergy anergy NN cord-259669-fod4xkd7 48 26 . . . cord-259669-fod4xkd7 49 1 Such such JJ cord-259669-fod4xkd7 49 2 processes process NNS cord-259669-fod4xkd7 49 3 are be VBP cord-259669-fod4xkd7 49 4 involved involve VBN cord-259669-fod4xkd7 49 5 in in IN cord-259669-fod4xkd7 49 6 responses response NNS cord-259669-fod4xkd7 49 7 to to IN cord-259669-fod4xkd7 49 8 self self NN cord-259669-fod4xkd7 49 9 - - HYPH cord-259669-fod4xkd7 49 10 antigens antigen NNS cord-259669-fod4xkd7 49 11 and and CC cord-259669-fod4xkd7 49 12 tolerance tolerance NN cord-259669-fod4xkd7 49 13 of of IN cord-259669-fod4xkd7 49 14 food food NN cord-259669-fod4xkd7 49 15 antigens antigen NNS cord-259669-fod4xkd7 49 16 . . . cord-259669-fod4xkd7 50 1 Following follow VBG cord-259669-fod4xkd7 50 2 interaction interaction NN cord-259669-fod4xkd7 50 3 with with IN cord-259669-fod4xkd7 50 4 a a DT cord-259669-fod4xkd7 50 5 pathogen pathogen NN cord-259669-fod4xkd7 50 6 ( ( -LRB- cord-259669-fod4xkd7 50 7 and and CC cord-259669-fod4xkd7 50 8 its -PRON- PRP$ cord-259669-fod4xkd7 50 9 PAMPs pamp NNS cord-259669-fod4xkd7 50 10 ) ) -RRB- cord-259669-fod4xkd7 50 11 , , , cord-259669-fod4xkd7 50 12 cDC cDC NNP cord-259669-fod4xkd7 50 13 endocytic endocytic JJ cord-259669-fod4xkd7 50 14 activity activity NN cord-259669-fod4xkd7 50 15 - - : cord-259669-fod4xkd7 50 16 particularly particularly RB cord-259669-fod4xkd7 50 17 macropinocytosis macropinocytosis NN cord-259669-fod4xkd7 50 18 - - , cord-259669-fod4xkd7 50 19 is be VBZ cord-259669-fod4xkd7 50 20 enhanced enhance VBN cord-259669-fod4xkd7 50 21 during during IN cord-259669-fod4xkd7 50 22 the the DT cord-259669-fod4xkd7 50 23 first first JJ cord-259669-fod4xkd7 50 24 2 2 CD cord-259669-fod4xkd7 50 25 h h NN cord-259669-fod4xkd7 50 26 after after IN cord-259669-fod4xkd7 50 27 stimulation stimulation NN cord-259669-fod4xkd7 50 28 , , , cord-259669-fod4xkd7 50 29 followed follow VBN cord-259669-fod4xkd7 50 30 by by IN cord-259669-fod4xkd7 50 31 down down NN cord-259669-fod4xkd7 50 32 - - HYPH cord-259669-fod4xkd7 50 33 regulation regulation NN cord-259669-fod4xkd7 50 34 as as IN cord-259669-fod4xkd7 50 35 the the DT cord-259669-fod4xkd7 50 36 DC DC NNP cord-259669-fod4xkd7 50 37 mature mature NN cord-259669-fod4xkd7 50 38 . . . cord-259669-fod4xkd7 51 1 The the DT cord-259669-fod4xkd7 51 2 latter latter JJ cord-259669-fod4xkd7 51 3 relates relate VBZ cord-259669-fod4xkd7 51 4 to to IN cord-259669-fod4xkd7 51 5 a a DT cord-259669-fod4xkd7 51 6 prolonged prolong VBN cord-259669-fod4xkd7 51 7 capacity capacity NN cord-259669-fod4xkd7 51 8 for for IN cord-259669-fod4xkd7 51 9 efficient efficient JJ cord-259669-fod4xkd7 51 10 presentation presentation NN cord-259669-fod4xkd7 51 11 of of IN cord-259669-fod4xkd7 51 12 the the DT cord-259669-fod4xkd7 51 13 endocytosed endocytosed JJ cord-259669-fod4xkd7 51 14 and and CC cord-259669-fod4xkd7 51 15 processed process VBN cord-259669-fod4xkd7 51 16 antigen antigen NN cord-259669-fod4xkd7 51 17 [ [ -LRB- cord-259669-fod4xkd7 51 18 18 18 CD cord-259669-fod4xkd7 51 19 ] ] -RRB- cord-259669-fod4xkd7 51 20 . . . cord-259669-fod4xkd7 52 1 With with IN cord-259669-fod4xkd7 52 2 completion completion NN cord-259669-fod4xkd7 52 3 of of IN cord-259669-fod4xkd7 52 4 the the DT cord-259669-fod4xkd7 52 5 DC DC NNP cord-259669-fod4xkd7 52 6 maturation maturation NN cord-259669-fod4xkd7 52 7 process process NN cord-259669-fod4xkd7 52 8 , , , cord-259669-fod4xkd7 52 9 important important JJ cord-259669-fod4xkd7 52 10 biological biological JJ cord-259669-fod4xkd7 52 11 changes change NNS cord-259669-fod4xkd7 52 12 occur occur VBP cord-259669-fod4xkd7 52 13 to to IN cord-259669-fod4xkd7 52 14 the the DT cord-259669-fod4xkd7 52 15 DC DC NNP cord-259669-fod4xkd7 52 16 . . . cord-259669-fod4xkd7 53 1 Chemokine chemokine JJ cord-259669-fod4xkd7 53 2 receptor receptor NN cord-259669-fod4xkd7 53 3 expression expression NN cord-259669-fod4xkd7 53 4 is be VBZ cord-259669-fod4xkd7 53 5 modified modify VBN cord-259669-fod4xkd7 53 6 , , , cord-259669-fod4xkd7 53 7 enabling enable VBG cord-259669-fod4xkd7 53 8 migration migration NN cord-259669-fod4xkd7 53 9 to to IN cord-259669-fod4xkd7 53 10 the the DT cord-259669-fod4xkd7 53 11 inductive inductive JJ cord-259669-fod4xkd7 53 12 sites site NNS cord-259669-fod4xkd7 53 13 of of IN cord-259669-fod4xkd7 53 14 the the DT cord-259669-fod4xkd7 53 15 adaptive adaptive JJ cord-259669-fod4xkd7 53 16 immune immune JJ cord-259669-fod4xkd7 53 17 system system NN cord-259669-fod4xkd7 53 18 . . . cord-259669-fod4xkd7 54 1 For for IN cord-259669-fod4xkd7 54 2 example example NN cord-259669-fod4xkd7 54 3 , , , cord-259669-fod4xkd7 54 4 the the DT cord-259669-fod4xkd7 54 5 CCR1 CCR1 NNP cord-259669-fod4xkd7 54 6 and and CC cord-259669-fod4xkd7 54 7 CCR5 CCR5 NNP cord-259669-fod4xkd7 54 8 receptors receptor NNS cord-259669-fod4xkd7 54 9 for for IN cord-259669-fod4xkd7 54 10 inflammatory inflammatory JJ cord-259669-fod4xkd7 54 11 chemokines chemokine NNS cord-259669-fod4xkd7 54 12 such such JJ cord-259669-fod4xkd7 54 13 as as IN cord-259669-fod4xkd7 54 14 CCL3 CCL3 NNP cord-259669-fod4xkd7 54 15 and and CC cord-259669-fod4xkd7 54 16 CCL5 CCL5 NNP cord-259669-fod4xkd7 54 17 are be VBP cord-259669-fod4xkd7 54 18 down down RB cord-259669-fod4xkd7 54 19 - - HYPH cord-259669-fod4xkd7 54 20 regulated regulated JJ cord-259669-fod4xkd7 54 21 , , , cord-259669-fod4xkd7 54 22 while while IN cord-259669-fod4xkd7 54 23 the the DT cord-259669-fod4xkd7 54 24 CCR7 CCR7 NNP cord-259669-fod4xkd7 54 25 receptor receptor NN cord-259669-fod4xkd7 54 26 for for IN cord-259669-fod4xkd7 54 27 CCL19 CCL19 NNP cord-259669-fod4xkd7 54 28 and and CC cord-259669-fod4xkd7 54 29 CCL21 CCL21 NNP cord-259669-fod4xkd7 54 30 is be VBZ cord-259669-fod4xkd7 54 31 up up RB cord-259669-fod4xkd7 54 32 - - HYPH cord-259669-fod4xkd7 54 33 regulated regulate VBN cord-259669-fod4xkd7 54 34 [ [ -LRB- cord-259669-fod4xkd7 54 35 8 8 CD cord-259669-fod4xkd7 54 36 ] ] -RRB- cord-259669-fod4xkd7 54 37 . . . cord-259669-fod4xkd7 55 1 The the DT cord-259669-fod4xkd7 55 2 latter latter JJ cord-259669-fod4xkd7 55 3 provides provide VBZ cord-259669-fod4xkd7 55 4 DC DC NNP cord-259669-fod4xkd7 55 5 with with IN cord-259669-fod4xkd7 55 6 the the DT cord-259669-fod4xkd7 55 7 signal signal NN cord-259669-fod4xkd7 55 8 for for IN cord-259669-fod4xkd7 55 9 entry entry NN cord-259669-fod4xkd7 55 10 into into IN cord-259669-fod4xkd7 55 11 the the DT cord-259669-fod4xkd7 55 12 inductive inductive JJ cord-259669-fod4xkd7 55 13 sites site NNS cord-259669-fod4xkd7 55 14 of of IN cord-259669-fod4xkd7 55 15 the the DT cord-259669-fod4xkd7 55 16 adaptive adaptive JJ cord-259669-fod4xkd7 55 17 immune immune JJ cord-259669-fod4xkd7 55 18 system system NN cord-259669-fod4xkd7 55 19 such such JJ cord-259669-fod4xkd7 55 20 as as IN cord-259669-fod4xkd7 55 21 the the DT cord-259669-fod4xkd7 55 22 lymph lymph NN cord-259669-fod4xkd7 55 23 node node NN cord-259669-fod4xkd7 55 24 . . . cord-259669-fod4xkd7 56 1 DC DC NNP cord-259669-fod4xkd7 56 2 activation activation NN cord-259669-fod4xkd7 56 3 also also RB cord-259669-fod4xkd7 56 4 results result VBZ cord-259669-fod4xkd7 56 5 in in IN cord-259669-fod4xkd7 56 6 an an DT cord-259669-fod4xkd7 56 7 increase increase NN cord-259669-fod4xkd7 56 8 of of IN cord-259669-fod4xkd7 56 9 cell cell NN cord-259669-fod4xkd7 56 10 surface surface NN cord-259669-fod4xkd7 56 11 MHC MHC NNP cord-259669-fod4xkd7 56 12 and and CC cord-259669-fod4xkd7 56 13 co co JJ cord-259669-fod4xkd7 56 14 - - JJ cord-259669-fod4xkd7 56 15 stimulatory stimulatory JJ cord-259669-fod4xkd7 56 16 molecule molecule NN cord-259669-fod4xkd7 56 17 expression expression NN cord-259669-fod4xkd7 56 18 - - : cord-259669-fod4xkd7 56 19 such such JJ cord-259669-fod4xkd7 56 20 as as IN cord-259669-fod4xkd7 56 21 CD80 CD80 NNP cord-259669-fod4xkd7 56 22 and and CC cord-259669-fod4xkd7 56 23 CD86-as CD86-as NNP cord-259669-fod4xkd7 57 1 well well UH cord-259669-fod4xkd7 57 2 as as IN cord-259669-fod4xkd7 57 3 the the DT cord-259669-fod4xkd7 57 4 production production NN cord-259669-fod4xkd7 57 5 of of IN cord-259669-fod4xkd7 57 6 immunoregulatory immunoregulatory NNP cord-259669-fod4xkd7 57 7 and/or and/or CC cord-259669-fod4xkd7 57 8 inflammatory inflammatory JJ cord-259669-fod4xkd7 57 9 cytokines cytokine NNS cord-259669-fod4xkd7 57 10 . . . cord-259669-fod4xkd7 58 1 MHC MHC NNP cord-259669-fod4xkd7 58 2 class class NN cord-259669-fod4xkd7 58 3 II II NNP cord-259669-fod4xkd7 58 4 antigenic antigenic JJ cord-259669-fod4xkd7 58 5 peptide peptide NN cord-259669-fod4xkd7 58 6 complexes complex NNS cord-259669-fod4xkd7 58 7 are be VBP cord-259669-fod4xkd7 58 8 stabilized stabilize VBN cord-259669-fod4xkd7 58 9 on on IN cord-259669-fod4xkd7 58 10 the the DT cord-259669-fod4xkd7 58 11 cell cell NN cord-259669-fod4xkd7 58 12 surface surface NN cord-259669-fod4xkd7 58 13 to to TO cord-259669-fod4xkd7 58 14 ensure ensure VB cord-259669-fod4xkd7 58 15 efficient efficient JJ cord-259669-fod4xkd7 58 16 stimulation stimulation NN cord-259669-fod4xkd7 58 17 of of IN cord-259669-fod4xkd7 58 18 T t NN cord-259669-fod4xkd7 58 19 - - HYPH cord-259669-fod4xkd7 58 20 cell cell NN cord-259669-fod4xkd7 58 21 responses response NNS cord-259669-fod4xkd7 58 22 . . . cord-259669-fod4xkd7 59 1 Overall overall RB cord-259669-fod4xkd7 59 2 , , , cord-259669-fod4xkd7 59 3 the the DT cord-259669-fod4xkd7 59 4 induced induce VBN cord-259669-fod4xkd7 59 5 functional functional JJ cord-259669-fod4xkd7 59 6 changes change NNS cord-259669-fod4xkd7 59 7 are be VBP cord-259669-fod4xkd7 59 8 usually usually RB cord-259669-fod4xkd7 59 9 associated associate VBN cord-259669-fod4xkd7 59 10 with with IN cord-259669-fod4xkd7 59 11 increased increase VBN cord-259669-fod4xkd7 59 12 T t NN cord-259669-fod4xkd7 59 13 - - HYPH cord-259669-fod4xkd7 59 14 lymphocyte lymphocyte NN cord-259669-fod4xkd7 59 15 stimulatory stimulatory JJ cord-259669-fod4xkd7 59 16 capacity capacity NN cord-259669-fod4xkd7 59 17 , , , cord-259669-fod4xkd7 59 18 although although IN cord-259669-fod4xkd7 59 19 this this DT cord-259669-fod4xkd7 59 20 depends depend VBZ cord-259669-fod4xkd7 59 21 on on IN cord-259669-fod4xkd7 59 22 the the DT cord-259669-fod4xkd7 59 23 stimulus stimulus NN cord-259669-fod4xkd7 59 24 received receive VBD cord-259669-fod4xkd7 59 25 [ [ -LRB- cord-259669-fod4xkd7 59 26 19 19 CD cord-259669-fod4xkd7 59 27 ] ] -RRB- cord-259669-fod4xkd7 59 28 . . . cord-259669-fod4xkd7 60 1 Clearly clearly RB cord-259669-fod4xkd7 60 2 , , , cord-259669-fod4xkd7 60 3 the the DT cord-259669-fod4xkd7 60 4 interaction interaction NN cord-259669-fod4xkd7 60 5 of of IN cord-259669-fod4xkd7 60 6 microbial microbial JJ cord-259669-fod4xkd7 60 7 pathogens pathogen NNS cord-259669-fod4xkd7 60 8 with with IN cord-259669-fod4xkd7 60 9 DC DC NNP cord-259669-fod4xkd7 60 10 can can MD cord-259669-fod4xkd7 60 11 provide provide VB cord-259669-fod4xkd7 60 12 insight insight NN cord-259669-fod4xkd7 60 13 into into IN cord-259669-fod4xkd7 60 14 the the DT cord-259669-fod4xkd7 60 15 pathogenesis pathogenesis NN cord-259669-fod4xkd7 60 16 of of IN cord-259669-fod4xkd7 60 17 and and CC cord-259669-fod4xkd7 60 18 defence defence NN cord-259669-fod4xkd7 60 19 against against IN cord-259669-fod4xkd7 60 20 infectious infectious JJ cord-259669-fod4xkd7 60 21 diseases disease NNS cord-259669-fod4xkd7 60 22 . . . cord-259669-fod4xkd7 61 1 Moreover moreover RB cord-259669-fod4xkd7 61 2 , , , cord-259669-fod4xkd7 61 3 the the DT cord-259669-fod4xkd7 61 4 central central JJ cord-259669-fod4xkd7 61 5 role role NN cord-259669-fod4xkd7 61 6 of of IN cord-259669-fod4xkd7 61 7 DC DC NNP cord-259669-fod4xkd7 61 8 in in IN cord-259669-fod4xkd7 61 9 immune immune JJ cord-259669-fod4xkd7 61 10 defence defence NN cord-259669-fod4xkd7 61 11 development development NN cord-259669-fod4xkd7 61 12 makes make VBZ cord-259669-fod4xkd7 61 13 them -PRON- PRP cord-259669-fod4xkd7 61 14 a a DT cord-259669-fod4xkd7 61 15 prime prime JJ cord-259669-fod4xkd7 61 16 target target NN cord-259669-fod4xkd7 61 17 for for IN cord-259669-fod4xkd7 61 18 vaccines vaccine NNS cord-259669-fod4xkd7 61 19 and and CC cord-259669-fod4xkd7 61 20 immunotherapies immunotherapy NNS cord-259669-fod4xkd7 61 21 . . . cord-259669-fod4xkd7 62 1 Recent recent JJ cord-259669-fod4xkd7 62 2 advances advance NNS cord-259669-fod4xkd7 62 3 in in IN cord-259669-fod4xkd7 62 4 porcine porcine JJ cord-259669-fod4xkd7 62 5 immunology immunology NN cord-259669-fod4xkd7 62 6 have have VBP cord-259669-fod4xkd7 62 7 allowed allow VBN cord-259669-fod4xkd7 62 8 the the DT cord-259669-fod4xkd7 62 9 characterization characterization NN cord-259669-fod4xkd7 62 10 of of IN cord-259669-fod4xkd7 62 11 the the DT cord-259669-fod4xkd7 62 12 porcine porcine JJ cord-259669-fod4xkd7 62 13 DC DC NNP cord-259669-fod4xkd7 62 14 system system NN cord-259669-fod4xkd7 62 15 in in IN cord-259669-fod4xkd7 62 16 this this DT cord-259669-fod4xkd7 62 17 direction direction NN cord-259669-fod4xkd7 62 18 ( ( -LRB- cord-259669-fod4xkd7 62 19 as as IN cord-259669-fod4xkd7 62 20 witnessed witness VBN cord-259669-fod4xkd7 62 21 by by IN cord-259669-fod4xkd7 62 22 the the DT cord-259669-fod4xkd7 62 23 identified identify VBN cord-259669-fod4xkd7 62 24 cell cell NN cord-259669-fod4xkd7 62 25 types type NNS cord-259669-fod4xkd7 62 26 shown show VBN cord-259669-fod4xkd7 62 27 in in IN cord-259669-fod4xkd7 62 28 Table Table NNP cord-259669-fod4xkd7 62 29 1 1 CD cord-259669-fod4xkd7 62 30 ) ) -RRB- cord-259669-fod4xkd7 62 31 . . . cord-259669-fod4xkd7 63 1 This this DT cord-259669-fod4xkd7 63 2 has have VBZ cord-259669-fod4xkd7 63 3 also also RB cord-259669-fod4xkd7 63 4 been be VBN cord-259669-fod4xkd7 63 5 possible possible JJ cord-259669-fod4xkd7 63 6 through through IN cord-259669-fod4xkd7 63 7 the the DT cord-259669-fod4xkd7 63 8 availability availability NN cord-259669-fod4xkd7 63 9 of of IN cord-259669-fod4xkd7 63 10 antibodies antibody NNS cord-259669-fod4xkd7 63 11 against against IN cord-259669-fod4xkd7 63 12 cell cell NN cord-259669-fod4xkd7 63 13 surface surface NN cord-259669-fod4xkd7 63 14 markers marker NNS cord-259669-fod4xkd7 63 15 classified classify VBN cord-259669-fod4xkd7 63 16 in in IN cord-259669-fod4xkd7 63 17 three three CD cord-259669-fod4xkd7 63 18 international international JJ cord-259669-fod4xkd7 63 19 swine swine NN cord-259669-fod4xkd7 63 20 CD cd NN cord-259669-fod4xkd7 63 21 workshops workshop NNS cord-259669-fod4xkd7 63 22 [ [ -LRB- cord-259669-fod4xkd7 63 23 20 20 CD cord-259669-fod4xkd7 63 24 ] ] -RRB- cord-259669-fod4xkd7 63 25 [ [ -LRB- cord-259669-fod4xkd7 63 26 21 21 CD cord-259669-fod4xkd7 63 27 ] ] -RRB- cord-259669-fod4xkd7 63 28 [ [ -LRB- cord-259669-fod4xkd7 63 29 22 22 CD cord-259669-fod4xkd7 63 30 ] ] -RRB- cord-259669-fod4xkd7 63 31 and and CC cord-259669-fod4xkd7 63 32 studies study NNS cord-259669-fod4xkd7 63 33 using use VBG cord-259669-fod4xkd7 63 34 crossreactive crossreactive JJ cord-259669-fod4xkd7 63 35 antibodies antibody NNS cord-259669-fod4xkd7 63 36 - - , cord-259669-fod4xkd7 63 37 summarized summarize VBN cord-259669-fod4xkd7 63 38 in in IN cord-259669-fod4xkd7 63 39 Table Table NNP cord-259669-fod4xkd7 63 40 2 2 CD cord-259669-fod4xkd7 63 41 . . . cord-259669-fod4xkd7 64 1 By by IN cord-259669-fod4xkd7 64 2 such such JJ cord-259669-fod4xkd7 64 3 means mean NNS cord-259669-fod4xkd7 64 4 , , , cord-259669-fod4xkd7 64 5 rapid rapid JJ cord-259669-fod4xkd7 64 6 advancement advancement NN cord-259669-fod4xkd7 64 7 in in IN cord-259669-fod4xkd7 64 8 the the DT cord-259669-fod4xkd7 64 9 current current JJ cord-259669-fod4xkd7 64 10 knowledge knowledge NN cord-259669-fod4xkd7 64 11 on on IN cord-259669-fod4xkd7 64 12 porcine porcine JJ cord-259669-fod4xkd7 64 13 APC APC NNP cord-259669-fod4xkd7 64 14 and and CC cord-259669-fod4xkd7 64 15 the the DT cord-259669-fod4xkd7 64 16 diversity diversity NN cord-259669-fod4xkd7 64 17 of of IN cord-259669-fod4xkd7 64 18 porcine porcine JJ cord-259669-fod4xkd7 64 19 DC DC NNP cord-259669-fod4xkd7 64 20 function function NN cord-259669-fod4xkd7 64 21 has have VBZ cord-259669-fod4xkd7 64 22 been be VBN cord-259669-fod4xkd7 64 23 forthcoming forthcoming JJ cord-259669-fod4xkd7 64 24 . . . cord-259669-fod4xkd7 65 1 The the DT cord-259669-fod4xkd7 65 2 subsequent subsequent JJ cord-259669-fod4xkd7 65 3 sections section NNS cord-259669-fod4xkd7 65 4 of of IN cord-259669-fod4xkd7 65 5 this this DT cord-259669-fod4xkd7 65 6 review review NN cord-259669-fod4xkd7 65 7 will will MD cord-259669-fod4xkd7 65 8 present present VB cord-259669-fod4xkd7 65 9 these these DT cord-259669-fod4xkd7 65 10 advancements advancement NNS cord-259669-fod4xkd7 65 11 . . . cord-259669-fod4xkd7 66 1 Similar similar JJ cord-259669-fod4xkd7 66 2 to to IN cord-259669-fod4xkd7 66 3 other other JJ cord-259669-fod4xkd7 66 4 species specie NNS cord-259669-fod4xkd7 66 5 , , , cord-259669-fod4xkd7 66 6 porcine porcine JJ cord-259669-fod4xkd7 66 7 DC DC NNP cord-259669-fod4xkd7 66 8 can can MD cord-259669-fod4xkd7 66 9 be be VB cord-259669-fod4xkd7 66 10 generated generate VBN cord-259669-fod4xkd7 66 11 by by IN cord-259669-fod4xkd7 66 12 stimulating stimulate VBG cord-259669-fod4xkd7 66 13 blood blood NN cord-259669-fod4xkd7 66 14 monocytes monocyte NNS cord-259669-fod4xkd7 66 15 with with IN cord-259669-fod4xkd7 66 16 interleukin-4 interleukin-4 NNP cord-259669-fod4xkd7 66 17 ( ( -LRB- cord-259669-fod4xkd7 66 18 IL-4 IL-4 NNP cord-259669-fod4xkd7 66 19 ) ) -RRB- cord-259669-fod4xkd7 66 20 and and CC cord-259669-fod4xkd7 66 21 granulocyte granulocyte NN cord-259669-fod4xkd7 66 22 macrophage macrophage NN cord-259669-fod4xkd7 66 23 - - HYPH cord-259669-fod4xkd7 66 24 colony colony NN cord-259669-fod4xkd7 66 25 - - HYPH cord-259669-fod4xkd7 66 26 stimulating stimulate VBG cord-259669-fod4xkd7 66 27 factor factor NN cord-259669-fod4xkd7 66 28 ( ( -LRB- cord-259669-fod4xkd7 66 29 GM GM NNP cord-259669-fod4xkd7 66 30 - - HYPH cord-259669-fod4xkd7 66 31 CSF CSF NNP cord-259669-fod4xkd7 66 32 ) ) -RRB- cord-259669-fod4xkd7 66 33 . . . cord-259669-fod4xkd7 67 1 After after IN cord-259669-fod4xkd7 67 2 3 3 CD cord-259669-fod4xkd7 67 3 - - SYM cord-259669-fod4xkd7 67 4 7 7 CD cord-259669-fod4xkd7 67 5 days day NNS cord-259669-fod4xkd7 67 6 of of IN cord-259669-fod4xkd7 67 7 culture culture NN cord-259669-fod4xkd7 67 8 , , , cord-259669-fod4xkd7 67 9 non non JJ cord-259669-fod4xkd7 67 10 - - JJ cord-259669-fod4xkd7 67 11 adherent adherent JJ cord-259669-fod4xkd7 67 12 or or CC cord-259669-fod4xkd7 67 13 loosely loosely RB cord-259669-fod4xkd7 67 14 adherent adherent JJ cord-259669-fod4xkd7 67 15 cells cell NNS cord-259669-fod4xkd7 67 16 with with IN cord-259669-fod4xkd7 67 17 dendritic dendritic JJ cord-259669-fod4xkd7 67 18 morphology morphology NN cord-259669-fod4xkd7 67 19 can can MD cord-259669-fod4xkd7 67 20 be be VB cord-259669-fod4xkd7 67 21 harvested harvest VBN cord-259669-fod4xkd7 67 22 [ [ -LRB- cord-259669-fod4xkd7 67 23 23 23 CD cord-259669-fod4xkd7 67 24 , , , cord-259669-fod4xkd7 67 25 24 24 CD cord-259669-fod4xkd7 67 26 ] ] -RRB- cord-259669-fod4xkd7 67 27 . . . cord-259669-fod4xkd7 68 1 Generation generation NN cord-259669-fod4xkd7 68 2 of of IN cord-259669-fod4xkd7 68 3 monocyte monocyte NNP cord-259669-fod4xkd7 68 4 - - HYPH cord-259669-fod4xkd7 68 5 derived derive VBN cord-259669-fod4xkd7 68 6 DC DC NNP cord-259669-fod4xkd7 68 7 ( ( -LRB- cord-259669-fod4xkd7 68 8 MoDC MoDC NNP cord-259669-fod4xkd7 68 9 ) ) -RRB- cord-259669-fod4xkd7 68 10 in in IN cord-259669-fod4xkd7 68 11 vitro vitro FW cord-259669-fod4xkd7 68 12 can can MD cord-259669-fod4xkd7 68 13 also also RB cord-259669-fod4xkd7 68 14 employ employ VB cord-259669-fod4xkd7 68 15 a a DT cord-259669-fod4xkd7 68 16 GM GM NNP cord-259669-fod4xkd7 68 17 - - HYPH cord-259669-fod4xkd7 68 18 CSF/ CSF/ NNP cord-259669-fod4xkd7 68 19 IFN IFN NNP cord-259669-fod4xkd7 68 20 - - : cord-259669-fod4xkd7 68 21 a a DT cord-259669-fod4xkd7 68 22 combination combination NN cord-259669-fod4xkd7 68 23 . . . cord-259669-fod4xkd7 69 1 This this DT cord-259669-fod4xkd7 69 2 can can MD cord-259669-fod4xkd7 69 3 prove prove VB cord-259669-fod4xkd7 69 4 more more RBR cord-259669-fod4xkd7 69 5 potent potent JJ cord-259669-fod4xkd7 69 6 than than IN cord-259669-fod4xkd7 69 7 the the DT cord-259669-fod4xkd7 69 8 GM GM NNP cord-259669-fod4xkd7 69 9 - - HYPH cord-259669-fod4xkd7 69 10 CSF/ CSF/ NNP cord-259669-fod4xkd7 69 11 IL4 il4 NN cord-259669-fod4xkd7 69 12 method method NN cord-259669-fod4xkd7 69 13 when when WRB cord-259669-fod4xkd7 69 14 seeking seek VBG cord-259669-fod4xkd7 69 15 DC DC NNP cord-259669-fod4xkd7 69 16 for for IN cord-259669-fod4xkd7 69 17 restimulating restimulate VBG cord-259669-fod4xkd7 69 18 virus virus NN cord-259669-fod4xkd7 69 19 - - HYPH cord-259669-fod4xkd7 69 20 specific specific JJ cord-259669-fod4xkd7 69 21 cytotoxic cytotoxic JJ cord-259669-fod4xkd7 69 22 T t NN cord-259669-fod4xkd7 69 23 - - HYPH cord-259669-fod4xkd7 69 24 cells cell NNS cord-259669-fod4xkd7 69 25 [ [ -LRB- cord-259669-fod4xkd7 69 26 25 25 CD cord-259669-fod4xkd7 69 27 ] ] -RRB- cord-259669-fod4xkd7 69 28 . . . cord-259669-fod4xkd7 70 1 Addition addition NN cord-259669-fod4xkd7 70 2 of of IN cord-259669-fod4xkd7 70 3 IFN IFN NNP cord-259669-fod4xkd7 70 4 - - : cord-259669-fod4xkd7 70 5 a a NN cord-259669-fod4xkd7 70 6 to to IN cord-259669-fod4xkd7 70 7 the the DT cord-259669-fod4xkd7 70 8 GM GM NNP cord-259669-fod4xkd7 70 9 - - HYPH cord-259669-fod4xkd7 70 10 CSF CSF NNP cord-259669-fod4xkd7 70 11 / / , cord-259669-fod4xkd7 70 12 IL-4 IL-4 NNP cord-259669-fod4xkd7 70 13 cocktail cocktail NN cord-259669-fod4xkd7 70 14 also also RB cord-259669-fod4xkd7 70 15 influences influence VBZ cord-259669-fod4xkd7 70 16 the the DT cord-259669-fod4xkd7 70 17 DC DC NNP cord-259669-fod4xkd7 70 18 , , , cord-259669-fod4xkd7 70 19 resulting result VBG cord-259669-fod4xkd7 70 20 in in IN cord-259669-fod4xkd7 70 21 an an DT cord-259669-fod4xkd7 70 22 enhanced enhanced JJ cord-259669-fod4xkd7 70 23 T t NN cord-259669-fod4xkd7 70 24 - - HYPH cord-259669-fod4xkd7 70 25 cell cell NN cord-259669-fod4xkd7 70 26 a a DT cord-259669-fod4xkd7 70 27 Two two CD cord-259669-fod4xkd7 70 28 subsets subset NNS cord-259669-fod4xkd7 70 29 . . . cord-259669-fod4xkd7 71 1 b b LS cord-259669-fod4xkd7 71 2 Variable variable NN cord-259669-fod4xkd7 71 3 , , , cord-259669-fod4xkd7 71 4 two two CD cord-259669-fod4xkd7 71 5 subsets subset NNS cord-259669-fod4xkd7 71 6 with with IN cord-259669-fod4xkd7 71 7 some some DT cord-259669-fod4xkd7 71 8 animals animal NNS cord-259669-fod4xkd7 71 9 ( ( -LRB- cord-259669-fod4xkd7 71 10 see see VB cord-259669-fod4xkd7 71 11 also also RB cord-259669-fod4xkd7 71 12 Fig Fig NNP cord-259669-fod4xkd7 71 13 . . NNP cord-259669-fod4xkd7 71 14 1 1 CD cord-259669-fod4xkd7 71 15 ) ) -RRB- cord-259669-fod4xkd7 71 16 . . . cord-259669-fod4xkd7 72 1 c c NNP cord-259669-fod4xkd7 72 2 Can Can MD cord-259669-fod4xkd7 72 3 be be VB cord-259669-fod4xkd7 72 4 negative negative JJ cord-259669-fod4xkd7 72 5 in in IN cord-259669-fod4xkd7 72 6 mucosal mucosal JJ cord-259669-fod4xkd7 72 7 tissue tissue NN cord-259669-fod4xkd7 72 8 [ [ -LRB- cord-259669-fod4xkd7 72 9 55 55 CD cord-259669-fod4xkd7 72 10 ] ] -RRB- cord-259669-fod4xkd7 72 11 . . . cord-259669-fod4xkd7 73 1 d d LS cord-259669-fod4xkd7 73 2 Not not RB cord-259669-fod4xkd7 73 3 determined determined JJ cord-259669-fod4xkd7 73 4 . . . cord-259669-fod4xkd7 74 1 e e LS cord-259669-fod4xkd7 74 2 Four four CD cord-259669-fod4xkd7 74 3 subsets subset NNS cord-259669-fod4xkd7 74 4 based base VBN cord-259669-fod4xkd7 74 5 on on IN cord-259669-fod4xkd7 74 6 CD172a CD172a NNP cord-259669-fod4xkd7 74 7 / / SYM cord-259669-fod4xkd7 74 8 CD11RI cd11ri JJ cord-259669-fod4xkd7 74 9 expression expression NN cord-259669-fod4xkd7 74 10 and and CC cord-259669-fod4xkd7 74 11 dependent dependent JJ cord-259669-fod4xkd7 74 12 on on IN cord-259669-fod4xkd7 74 13 localization localization NN cord-259669-fod4xkd7 74 14 in in IN cord-259669-fod4xkd7 74 15 LP LP NNP cord-259669-fod4xkd7 74 16 , , , cord-259669-fod4xkd7 74 17 PP PP NNP cord-259669-fod4xkd7 74 18 and and CC cord-259669-fod4xkd7 74 19 MLN MLN NNP cord-259669-fod4xkd7 74 20 [ [ -LRB- cord-259669-fod4xkd7 74 21 47 47 CD cord-259669-fod4xkd7 74 22 ] ] -RRB- cord-259669-fod4xkd7 74 23 . . . cord-259669-fod4xkd7 75 1 f f LS cord-259669-fod4xkd7 75 2 Negative Negative NNP cord-259669-fod4xkd7 75 3 on on IN cord-259669-fod4xkd7 75 4 LP LP NNP cord-259669-fod4xkd7 75 5 DC DC NNP cord-259669-fod4xkd7 75 6 [ [ -LRB- cord-259669-fod4xkd7 75 7 46 46 CD cord-259669-fod4xkd7 75 8 ] ] -RRB- cord-259669-fod4xkd7 75 9 . . . cord-259669-fod4xkd7 76 1 g g NNP cord-259669-fod4xkd7 76 2 Two two CD cord-259669-fod4xkd7 76 3 subsets subset NNS cord-259669-fod4xkd7 76 4 : : : cord-259669-fod4xkd7 77 1 CD172a cd172a NN cord-259669-fod4xkd7 77 2 + + CC cord-259669-fod4xkd7 77 3 CD1 CD1 NNP cord-259669-fod4xkd7 77 4 + + CC cord-259669-fod4xkd7 77 5 CD16 CD16 NNP cord-259669-fod4xkd7 78 1 + + CC cord-259669-fod4xkd7 79 1 and and CC cord-259669-fod4xkd7 79 2 CD172a CD172a NNP cord-259669-fod4xkd7 79 3 À à NN cord-259669-fod4xkd7 79 4 CD1 CD1 NNP cord-259669-fod4xkd7 79 5 À À NNP cord-259669-fod4xkd7 79 6 CD16 CD16 NNP cord-259669-fod4xkd7 79 7 À à NN cord-259669-fod4xkd7 79 8 . . . cord-259669-fod4xkd7 80 1 stimulatory stimulatory JJ cord-259669-fod4xkd7 80 2 capacity capacity NN cord-259669-fod4xkd7 80 3 in in IN cord-259669-fod4xkd7 80 4 mixed mixed JJ cord-259669-fod4xkd7 80 5 leukocyte leukocyte NN cord-259669-fod4xkd7 80 6 cultures culture NNS cord-259669-fod4xkd7 80 7 [ [ -LRB- cord-259669-fod4xkd7 80 8 26 26 CD cord-259669-fod4xkd7 80 9 ] ] -RRB- cord-259669-fod4xkd7 80 10 . . . cord-259669-fod4xkd7 81 1 In in IN cord-259669-fod4xkd7 81 2 fact fact NN cord-259669-fod4xkd7 81 3 , , , cord-259669-fod4xkd7 81 4 cytokine cytokine NN cord-259669-fod4xkd7 81 5 modulation modulation NN cord-259669-fod4xkd7 81 6 is be VBZ cord-259669-fod4xkd7 81 7 important important JJ cord-259669-fod4xkd7 81 8 for for IN cord-259669-fod4xkd7 81 9 manipulating manipulate VBG cord-259669-fod4xkd7 81 10 the the DT cord-259669-fod4xkd7 81 11 type type NN cord-259669-fod4xkd7 81 12 of of IN cord-259669-fod4xkd7 81 13 DC DC NNP cord-259669-fod4xkd7 81 14 generated generate VBN cord-259669-fod4xkd7 81 15 . . . cord-259669-fod4xkd7 82 1 TGF TGF NNP cord-259669-fod4xkd7 82 2 - - HYPH cord-259669-fod4xkd7 82 3 b b NNP cord-259669-fod4xkd7 82 4 permits permit VBZ cord-259669-fod4xkd7 82 5 the the DT cord-259669-fod4xkd7 82 6 generation generation NN cord-259669-fod4xkd7 82 7 of of IN cord-259669-fod4xkd7 82 8 cells cell NNS cord-259669-fod4xkd7 82 9 with with IN cord-259669-fod4xkd7 82 10 Langerhans Langerhans NNP cord-259669-fod4xkd7 82 11 cell cell NN cord-259669-fod4xkd7 82 12 characteristics characteristic NNS cord-259669-fod4xkd7 82 13 [ [ -LRB- cord-259669-fod4xkd7 82 14 24 24 CD cord-259669-fod4xkd7 82 15 ] ] -RRB- cord-259669-fod4xkd7 82 16 , , , cord-259669-fod4xkd7 82 17 while while IN cord-259669-fod4xkd7 82 18 PAMPs pamp NNS cord-259669-fod4xkd7 82 19 modulate modulate VBP cord-259669-fod4xkd7 82 20 mRNA mrna NN cord-259669-fod4xkd7 82 21 expression expression NN cord-259669-fod4xkd7 82 22 levels level NNS cord-259669-fod4xkd7 82 23 for for IN cord-259669-fod4xkd7 82 24 particular particular JJ cord-259669-fod4xkd7 82 25 TLRs tlr NNS cord-259669-fod4xkd7 82 26 [ [ -LRB- cord-259669-fod4xkd7 82 27 27 27 CD cord-259669-fod4xkd7 82 28 ] ] -RRB- cord-259669-fod4xkd7 82 29 . . . cord-259669-fod4xkd7 83 1 Bautista Bautista NNP cord-259669-fod4xkd7 83 2 et et NNP cord-259669-fod4xkd7 83 3 al al NNP cord-259669-fod4xkd7 83 4 . . . cord-259669-fod4xkd7 84 1 [ [ -LRB- cord-259669-fod4xkd7 84 2 28 28 CD cord-259669-fod4xkd7 84 3 ] ] -RRB- cord-259669-fod4xkd7 84 4 have have VBP cord-259669-fod4xkd7 84 5 also also RB cord-259669-fod4xkd7 84 6 demonstrated demonstrate VBN cord-259669-fod4xkd7 84 7 that that IN cord-259669-fod4xkd7 84 8 IL-4 IL-4 NNP cord-259669-fod4xkd7 84 9 can can MD cord-259669-fod4xkd7 84 10 be be VB cord-259669-fod4xkd7 84 11 replaced replace VBN cord-259669-fod4xkd7 84 12 by by IN cord-259669-fod4xkd7 84 13 IL-13 IL-13 NNP cord-259669-fod4xkd7 84 14 for for IN cord-259669-fod4xkd7 84 15 the the DT cord-259669-fod4xkd7 84 16 generation generation NN cord-259669-fod4xkd7 84 17 of of IN cord-259669-fod4xkd7 84 18 MoDC MoDC NNP cord-259669-fod4xkd7 84 19 . . . cord-259669-fod4xkd7 85 1 Phenotypically phenotypically RB cord-259669-fod4xkd7 85 2 , , , cord-259669-fod4xkd7 85 3 porcine porcine JJ cord-259669-fod4xkd7 85 4 MoDC modc NN cord-259669-fod4xkd7 85 5 are be VBP cord-259669-fod4xkd7 85 6 characterized characterize VBN cord-259669-fod4xkd7 85 7 as as IN cord-259669-fod4xkd7 85 8 CD1 CD1 NNP cord-259669-fod4xkd7 85 9 + + CC cord-259669-fod4xkd7 85 10 CD14 CD14 NNP cord-259669-fod4xkd7 85 11 + + SYM cord-259669-fod4xkd7 85 12 CD16 CD16 NNP cord-259669-fod4xkd7 85 13 + + SYM cord-259669-fod4xkd7 85 14 CD80/86 cd80/86 CD cord-259669-fod4xkd7 85 15 + + SYM cord-259669-fod4xkd7 85 16 CD172a cd172a NN cord-259669-fod4xkd7 85 17 + + CC cord-259669-fod4xkd7 85 18 and and CC cord-259669-fod4xkd7 85 19 MHC MHC NNP cord-259669-fod4xkd7 85 20 class class NN cord-259669-fod4xkd7 85 21 II II NNP cord-259669-fod4xkd7 85 22 + + CC cord-259669-fod4xkd7 85 23 [ [ -LRB- cord-259669-fod4xkd7 85 24 23 23 CD cord-259669-fod4xkd7 85 25 , , , cord-259669-fod4xkd7 85 26 24 24 CD cord-259669-fod4xkd7 85 27 , , , cord-259669-fod4xkd7 85 28 [ [ -LRB- cord-259669-fod4xkd7 85 29 28 28 CD cord-259669-fod4xkd7 85 30 ] ] -RRB- cord-259669-fod4xkd7 85 31 [ [ -LRB- cord-259669-fod4xkd7 85 32 29 29 CD cord-259669-fod4xkd7 85 33 ] ] -RRB- cord-259669-fod4xkd7 85 34 [ [ -LRB- cord-259669-fod4xkd7 85 35 30 30 CD cord-259669-fod4xkd7 85 36 ] ] -RRB- cord-259669-fod4xkd7 85 37 ( ( -LRB- cord-259669-fod4xkd7 85 38 Table table NN cord-259669-fod4xkd7 85 39 1 1 CD cord-259669-fod4xkd7 85 40 ) ) -RRB- cord-259669-fod4xkd7 85 41 . . . cord-259669-fod4xkd7 86 1 From from IN cord-259669-fod4xkd7 86 2 a a DT cord-259669-fod4xkd7 86 3 comparative comparative JJ cord-259669-fod4xkd7 86 4 immunological immunological JJ cord-259669-fod4xkd7 86 5 point point NN cord-259669-fod4xkd7 86 6 of of IN cord-259669-fod4xkd7 86 7 view view NN cord-259669-fod4xkd7 86 8 , , , cord-259669-fod4xkd7 86 9 it -PRON- PRP cord-259669-fod4xkd7 86 10 was be VBD cord-259669-fod4xkd7 86 11 unexpected unexpected JJ cord-259669-fod4xkd7 86 12 to to TO cord-259669-fod4xkd7 86 13 find find VB cord-259669-fod4xkd7 86 14 CD14 CD14 NNP cord-259669-fod4xkd7 86 15 , , , cord-259669-fod4xkd7 86 16 because because IN cord-259669-fod4xkd7 86 17 human human JJ cord-259669-fod4xkd7 86 18 CD14 CD14 NNP cord-259669-fod4xkd7 86 19 is be VBZ cord-259669-fod4xkd7 86 20 considered consider VBN cord-259669-fod4xkd7 86 21 to to TO cord-259669-fod4xkd7 86 22 be be VB cord-259669-fod4xkd7 86 23 a a DT cord-259669-fod4xkd7 86 24 typical typical JJ cord-259669-fod4xkd7 86 25 monocyte monocyte NNP cord-259669-fod4xkd7 86 26 / / SYM cord-259669-fod4xkd7 86 27 macrophage macrophage NN cord-259669-fod4xkd7 86 28 rather rather RB cord-259669-fod4xkd7 86 29 than than IN cord-259669-fod4xkd7 86 30 a a DT cord-259669-fod4xkd7 86 31 DC DC NNP cord-259669-fod4xkd7 86 32 marker marker NN cord-259669-fod4xkd7 86 33 [ [ -LRB- cord-259669-fod4xkd7 86 34 8 8 CD cord-259669-fod4xkd7 86 35 ] ] -RRB- cord-259669-fod4xkd7 86 36 . . . cord-259669-fod4xkd7 87 1 Nevertheless nevertheless RB cord-259669-fod4xkd7 87 2 , , , cord-259669-fod4xkd7 87 3 MoDC modc NN cord-259669-fod4xkd7 87 4 from from IN cord-259669-fod4xkd7 87 5 other other JJ cord-259669-fod4xkd7 87 6 species specie NNS cord-259669-fod4xkd7 87 7 such such JJ cord-259669-fod4xkd7 87 8 as as IN cord-259669-fod4xkd7 87 9 cat cat NN cord-259669-fod4xkd7 87 10 , , , cord-259669-fod4xkd7 87 11 cattle cattle NNS cord-259669-fod4xkd7 87 12 and and CC cord-259669-fod4xkd7 87 13 dog dog NN cord-259669-fod4xkd7 87 14 have have VBP cord-259669-fod4xkd7 87 15 also also RB cord-259669-fod4xkd7 87 16 been be VBN cord-259669-fod4xkd7 87 17 shown show VBN cord-259669-fod4xkd7 87 18 to to TO cord-259669-fod4xkd7 87 19 express express VB cord-259669-fod4xkd7 87 20 CD14 CD14 NNP cord-259669-fod4xkd7 87 21 [ [ -LRB- cord-259669-fod4xkd7 87 22 31 31 CD cord-259669-fod4xkd7 87 23 ] ] -RRB- cord-259669-fod4xkd7 87 24 . . . cord-259669-fod4xkd7 88 1 Of of IN cord-259669-fod4xkd7 88 2 the the DT cord-259669-fod4xkd7 88 3 other other JJ cord-259669-fod4xkd7 88 4 markers marker NNS cord-259669-fod4xkd7 88 5 , , , cord-259669-fod4xkd7 88 6 the the DT cord-259669-fod4xkd7 88 7 CD172a CD172a NNP cord-259669-fod4xkd7 88 8 was be VBD cord-259669-fod4xkd7 88 9 expected expect VBN cord-259669-fod4xkd7 88 10 due due IN cord-259669-fod4xkd7 88 11 to to IN cord-259669-fod4xkd7 88 12 its -PRON- PRP$ cord-259669-fod4xkd7 88 13 classification classification NN cord-259669-fod4xkd7 88 14 as as IN cord-259669-fod4xkd7 88 15 the the DT cord-259669-fod4xkd7 88 16 porcine porcine JJ cord-259669-fod4xkd7 88 17 swine swine NN cord-259669-fod4xkd7 88 18 workshop workshop NN cord-259669-fod4xkd7 88 19 cluster cluster NN cord-259669-fod4xkd7 88 20 3 3 CD cord-259669-fod4xkd7 89 1 ( ( -LRB- cord-259669-fod4xkd7 89 2 SWC3 SWC3 NNP cord-259669-fod4xkd7 89 3 ) ) -RRB- cord-259669-fod4xkd7 89 4 antigen antigen NN cord-259669-fod4xkd7 89 5 expressed express VBD cord-259669-fod4xkd7 89 6 on on IN cord-259669-fod4xkd7 89 7 cells cell NNS cord-259669-fod4xkd7 89 8 of of IN cord-259669-fod4xkd7 89 9 the the DT cord-259669-fod4xkd7 89 10 myelomonocytic myelomonocytic JJ cord-259669-fod4xkd7 89 11 lineage lineage NN cord-259669-fod4xkd7 89 12 [ [ -LRB- cord-259669-fod4xkd7 89 13 32 32 CD cord-259669-fod4xkd7 89 14 ] ] -RRB- cord-259669-fod4xkd7 89 15 . . . cord-259669-fod4xkd7 90 1 It -PRON- PRP cord-259669-fod4xkd7 90 2 is be VBZ cord-259669-fod4xkd7 90 3 expressed express VBN cord-259669-fod4xkd7 90 4 on on IN cord-259669-fod4xkd7 90 5 many many JJ cord-259669-fod4xkd7 90 6 monocytic monocytic JJ cord-259669-fod4xkd7 90 7 and and CC cord-259669-fod4xkd7 90 8 granulocytic granulocytic JJ cord-259669-fod4xkd7 90 9 cells cell NNS cord-259669-fod4xkd7 90 10 quite quite RB cord-259669-fod4xkd7 90 11 early early RB cord-259669-fod4xkd7 90 12 during during IN cord-259669-fod4xkd7 90 13 their -PRON- PRP$ cord-259669-fod4xkd7 90 14 differentiation differentiation NN cord-259669-fod4xkd7 90 15 [ [ -LRB- cord-259669-fod4xkd7 90 16 33 33 CD cord-259669-fod4xkd7 90 17 ] ] -RRB- cord-259669-fod4xkd7 90 18 . . . cord-259669-fod4xkd7 91 1 Functionally functionally RB cord-259669-fod4xkd7 91 2 , , , cord-259669-fod4xkd7 91 3 this this DT cord-259669-fod4xkd7 91 4 marker marker NN cord-259669-fod4xkd7 91 5 represents represent VBZ cord-259669-fod4xkd7 91 6 the the DT cord-259669-fod4xkd7 91 7 signal signal JJ cord-259669-fod4xkd7 91 8 regulatory regulatory JJ cord-259669-fod4xkd7 91 9 protein protein NN cord-259669-fod4xkd7 91 10 alpha alpha NN cord-259669-fod4xkd7 91 11 ( ( -LRB- cord-259669-fod4xkd7 91 12 SIRP SIRP NNP cord-259669-fod4xkd7 91 13 - - HYPH cord-259669-fod4xkd7 91 14 a a NN cord-259669-fod4xkd7 91 15 ) ) -RRB- cord-259669-fod4xkd7 91 16 . . . cord-259669-fod4xkd7 92 1 Altogether altogether RB cord-259669-fod4xkd7 92 2 , , , cord-259669-fod4xkd7 92 3 the the DT cord-259669-fod4xkd7 92 4 co co NN cord-259669-fod4xkd7 92 5 - - NN cord-259669-fod4xkd7 92 6 expression expression NN cord-259669-fod4xkd7 92 7 of of IN cord-259669-fod4xkd7 92 8 CD172a CD172a NNP cord-259669-fod4xkd7 92 9 and and CC cord-259669-fod4xkd7 92 10 CD1 CD1 NNP cord-259669-fod4xkd7 92 11 along along IN cord-259669-fod4xkd7 92 12 with with IN cord-259669-fod4xkd7 92 13 relatively relatively RB cord-259669-fod4xkd7 92 14 high high JJ cord-259669-fod4xkd7 92 15 levels level NNS cord-259669-fod4xkd7 92 16 of of IN cord-259669-fod4xkd7 92 17 both both DT cord-259669-fod4xkd7 92 18 CD80/86 cd80/86 CD cord-259669-fod4xkd7 92 19 and and CC cord-259669-fod4xkd7 92 20 MHC MHC NNP cord-259669-fod4xkd7 92 21 class class NN cord-259669-fod4xkd7 92 22 II II NNP cord-259669-fod4xkd7 92 23 represent represent VBP cord-259669-fod4xkd7 92 24 phenotypic phenotypic JJ cord-259669-fod4xkd7 92 25 characteristics characteristic NNS cord-259669-fod4xkd7 92 26 of of IN cord-259669-fod4xkd7 92 27 porcine porcine JJ cord-259669-fod4xkd7 92 28 MoDC modc NN cord-259669-fod4xkd7 92 29 but but CC cord-259669-fod4xkd7 92 30 no no DT cord-259669-fod4xkd7 92 31 marker marker NN cord-259669-fod4xkd7 92 32 clearly clearly RB cord-259669-fod4xkd7 92 33 differentiating differentiate VBG cord-259669-fod4xkd7 92 34 them -PRON- PRP cord-259669-fod4xkd7 92 35 from from IN cord-259669-fod4xkd7 92 36 monocyte monocyte NNP cord-259669-fod4xkd7 92 37 - - HYPH cord-259669-fod4xkd7 92 38 derived derive VBN cord-259669-fod4xkd7 92 39 macrophages macrophage NNS cord-259669-fod4xkd7 92 40 has have VBZ cord-259669-fod4xkd7 92 41 been be VBN cord-259669-fod4xkd7 92 42 identified identify VBN cord-259669-fod4xkd7 92 43 . . . cord-259669-fod4xkd7 93 1 Porcine porcine JJ cord-259669-fod4xkd7 93 2 MoDC modc NN cord-259669-fod4xkd7 93 3 generated generate VBN cord-259669-fod4xkd7 93 4 with with IN cord-259669-fod4xkd7 93 5 GM GM NNP cord-259669-fod4xkd7 93 6 - - HYPH cord-259669-fod4xkd7 93 7 CSF CSF NNP cord-259669-fod4xkd7 93 8 and and CC cord-259669-fod4xkd7 93 9 IL-4 IL-4 NNP cord-259669-fod4xkd7 93 10 relate relate VB cord-259669-fod4xkd7 93 11 to to IN cord-259669-fod4xkd7 93 12 human human JJ cord-259669-fod4xkd7 93 13 MoDC modc NN cord-259669-fod4xkd7 94 1 in in IN cord-259669-fod4xkd7 94 2 that that IN cord-259669-fod4xkd7 94 3 they -PRON- PRP cord-259669-fod4xkd7 94 4 are be VBP cord-259669-fod4xkd7 94 5 in in IN cord-259669-fod4xkd7 94 6 an an DT cord-259669-fod4xkd7 94 7 immature immature JJ cord-259669-fod4xkd7 94 8 state state NN cord-259669-fod4xkd7 94 9 , , , cord-259669-fod4xkd7 94 10 and and CC cord-259669-fod4xkd7 94 11 represent represent VB cord-259669-fod4xkd7 94 12 a a DT cord-259669-fod4xkd7 94 13 convenient convenient JJ cord-259669-fod4xkd7 94 14 cell cell NN cord-259669-fod4xkd7 94 15 culture culture NN cord-259669-fod4xkd7 94 16 model model NN cord-259669-fod4xkd7 94 17 to to TO cord-259669-fod4xkd7 94 18 study study VB cord-259669-fod4xkd7 94 19 the the DT cord-259669-fod4xkd7 94 20 DC DC NNP cord-259669-fod4xkd7 94 21 maturation maturation NN cord-259669-fod4xkd7 94 22 process process NN cord-259669-fod4xkd7 94 23 . . . cord-259669-fod4xkd7 95 1 Akin akin VB cord-259669-fod4xkd7 95 2 to to IN cord-259669-fod4xkd7 95 3 their -PRON- PRP$ cord-259669-fod4xkd7 95 4 human human JJ cord-259669-fod4xkd7 95 5 counterparts counterpart NNS cord-259669-fod4xkd7 95 6 , , , cord-259669-fod4xkd7 95 7 porcine porcine JJ cord-259669-fod4xkd7 95 8 MoDC modc NN cord-259669-fod4xkd7 95 9 up up RB cord-259669-fod4xkd7 95 10 - - HYPH cord-259669-fod4xkd7 95 11 regulate regulate VB cord-259669-fod4xkd7 95 12 CD80/86 cd80/86 CD cord-259669-fod4xkd7 95 13 , , , cord-259669-fod4xkd7 95 14 MHC MHC NNP cord-259669-fod4xkd7 95 15 classes class NNS cord-259669-fod4xkd7 95 16 I -PRON- PRP cord-259669-fod4xkd7 95 17 and and CC cord-259669-fod4xkd7 95 18 II II NNP cord-259669-fod4xkd7 95 19 , , , cord-259669-fod4xkd7 95 20 and and CC cord-259669-fod4xkd7 95 21 T t NN cord-259669-fod4xkd7 95 22 - - HYPH cord-259669-fod4xkd7 95 23 cell cell NN cord-259669-fod4xkd7 95 24 stimulatory stimulatory JJ cord-259669-fod4xkd7 95 25 activity activity NN cord-259669-fod4xkd7 95 26 upon upon IN cord-259669-fod4xkd7 95 27 maturation maturation NN cord-259669-fod4xkd7 95 28 , , , cord-259669-fod4xkd7 95 29 while while IN cord-259669-fod4xkd7 95 30 inflammatory inflammatory JJ cord-259669-fod4xkd7 95 31 chemokine chemokine NN cord-259669-fod4xkd7 95 32 receptors receptor NNS cord-259669-fod4xkd7 95 33 such such JJ cord-259669-fod4xkd7 95 34 as as IN cord-259669-fod4xkd7 95 35 CCR1 CCR1 NNP cord-259669-fod4xkd7 95 36 and and CC cord-259669-fod4xkd7 95 37 macropinocytic macropinocytic JJ cord-259669-fod4xkd7 95 38 activity activity NN cord-259669-fod4xkd7 95 39 are be VBP cord-259669-fod4xkd7 95 40 down down RB cord-259669-fod4xkd7 95 41 - - HYPH cord-259669-fod4xkd7 95 42 regulated regulate VBN cord-259669-fod4xkd7 95 43 [ [ -LRB- cord-259669-fod4xkd7 95 44 23 23 CD cord-259669-fod4xkd7 95 45 , , , cord-259669-fod4xkd7 95 46 24 24 CD cord-259669-fod4xkd7 95 47 , , , cord-259669-fod4xkd7 95 48 27 27 CD cord-259669-fod4xkd7 95 49 , , , cord-259669-fod4xkd7 95 50 [ [ -LRB- cord-259669-fod4xkd7 95 51 34 34 CD cord-259669-fod4xkd7 95 52 ] ] -RRB- cord-259669-fod4xkd7 95 53 [ [ -LRB- cord-259669-fod4xkd7 95 54 35 35 CD cord-259669-fod4xkd7 95 55 ] ] -RRB- cord-259669-fod4xkd7 95 56 [ [ -LRB- cord-259669-fod4xkd7 95 57 36 36 CD cord-259669-fod4xkd7 95 58 ] ] -RRB- cord-259669-fod4xkd7 95 59 . . . cord-259669-fod4xkd7 96 1 Porcine porcine JJ cord-259669-fod4xkd7 96 2 DC DC NNP cord-259669-fod4xkd7 96 3 , , , cord-259669-fod4xkd7 96 4 which which WDT cord-259669-fod4xkd7 96 5 phenotypically phenotypically RB cord-259669-fod4xkd7 96 6 and and CC cord-259669-fod4xkd7 96 7 functionally functionally RB cord-259669-fod4xkd7 96 8 resemble resemble JJ cord-259669-fod4xkd7 96 9 MoDC MoDC NNP cord-259669-fod4xkd7 96 10 , , , cord-259669-fod4xkd7 96 11 can can MD cord-259669-fod4xkd7 96 12 also also RB cord-259669-fod4xkd7 96 13 be be VB cord-259669-fod4xkd7 96 14 generated generate VBN cord-259669-fod4xkd7 96 15 from from IN cord-259669-fod4xkd7 96 16 bone bone NN cord-259669-fod4xkd7 96 17 marrow marrow NN cord-259669-fod4xkd7 96 18 haematopoietic haematopoietic JJ cord-259669-fod4xkd7 96 19 cells cell NNS cord-259669-fod4xkd7 96 20 ( ( -LRB- cord-259669-fod4xkd7 96 21 BMHC BMHC NNP cord-259669-fod4xkd7 96 22 ) ) -RRB- cord-259669-fod4xkd7 96 23 , , , cord-259669-fod4xkd7 96 24 stimulated stimulate VBN cord-259669-fod4xkd7 96 25 with with IN cord-259669-fod4xkd7 96 26 GM GM NNP cord-259669-fod4xkd7 96 27 - - HYPH cord-259669-fod4xkd7 96 28 CSF CSF NNP cord-259669-fod4xkd7 96 29 plus plus CC cord-259669-fod4xkd7 96 30 TNF TNF NNP cord-259669-fod4xkd7 96 31 - - HYPH cord-259669-fod4xkd7 96 32 a a NNP cord-259669-fod4xkd7 96 33 , , , cord-259669-fod4xkd7 96 34 or or CC cord-259669-fod4xkd7 96 35 GM GM NNP cord-259669-fod4xkd7 96 36 - - HYPH cord-259669-fod4xkd7 96 37 CSF CSF NNP cord-259669-fod4xkd7 96 38 alone alone RB cord-259669-fod4xkd7 96 39 , , , cord-259669-fod4xkd7 96 40 for for IN cord-259669-fod4xkd7 96 41 7 7 CD cord-259669-fod4xkd7 96 42 - - SYM cord-259669-fod4xkd7 96 43 10 10 CD cord-259669-fod4xkd7 96 44 days day NNS cord-259669-fod4xkd7 96 45 - - : cord-259669-fod4xkd7 96 46 BMDC BMDC NNP cord-259669-fod4xkd7 96 47 [ [ -LRB- cord-259669-fod4xkd7 96 48 23 23 CD cord-259669-fod4xkd7 96 49 ] ] -RRB- cord-259669-fod4xkd7 96 50 . . . cord-259669-fod4xkd7 97 1 Addition addition NN cord-259669-fod4xkd7 97 2 of of IN cord-259669-fod4xkd7 97 3 stem stem NN cord-259669-fod4xkd7 97 4 cell cell NN cord-259669-fod4xkd7 97 5 factor factor NN cord-259669-fod4xkd7 97 6 to to IN cord-259669-fod4xkd7 97 7 the the DT cord-259669-fod4xkd7 97 8 GM GM NNP cord-259669-fod4xkd7 97 9 - - HYPH cord-259669-fod4xkd7 97 10 CSF CSF NNP cord-259669-fod4xkd7 97 11 / / SYM cord-259669-fod4xkd7 97 12 TNF TNF NNP cord-259669-fod4xkd7 97 13 - - : cord-259669-fod4xkd7 97 14 a a DT cord-259669-fod4xkd7 97 15 cocktail cocktail NN cord-259669-fod4xkd7 97 16 increases increase VBZ cord-259669-fod4xkd7 97 17 the the DT cord-259669-fod4xkd7 97 18 yield yield NN cord-259669-fod4xkd7 97 19 of of IN cord-259669-fod4xkd7 97 20 DC DC NNP cord-259669-fod4xkd7 97 21 obtained obtain VBD cord-259669-fod4xkd7 97 22 [ [ -LRB- cord-259669-fod4xkd7 97 23 37 37 CD cord-259669-fod4xkd7 97 24 ] ] -RRB- cord-259669-fod4xkd7 97 25 . . . cord-259669-fod4xkd7 98 1 In in IN cord-259669-fod4xkd7 98 2 contrast contrast NN cord-259669-fod4xkd7 98 3 to to IN cord-259669-fod4xkd7 98 4 GM GM NNP cord-259669-fod4xkd7 98 5 - - HYPH cord-259669-fod4xkd7 98 6 CSF CSF NNP cord-259669-fod4xkd7 98 7 , , , cord-259669-fod4xkd7 98 8 Flt3 flt3 NN cord-259669-fod4xkd7 98 9 ligand ligand NN cord-259669-fod4xkd7 98 10 ( ( -LRB- cord-259669-fod4xkd7 99 1 Flt3L flt3l LS cord-259669-fod4xkd7 99 2 ) ) -RRB- cord-259669-fod4xkd7 99 3 stimulation stimulation NN cord-259669-fod4xkd7 99 4 induces induce VBZ cord-259669-fod4xkd7 99 5 the the DT cord-259669-fod4xkd7 99 6 differentiation differentiation NN cord-259669-fod4xkd7 99 7 of of IN cord-259669-fod4xkd7 99 8 both both DT cord-259669-fod4xkd7 99 9 cDC cDC NNP cord-259669-fod4xkd7 99 10 and and CC cord-259669-fod4xkd7 99 11 pDC pDC NNP cord-259669-fod4xkd7 99 12 , , , cord-259669-fod4xkd7 99 13 similar similar JJ cord-259669-fod4xkd7 99 14 to to IN cord-259669-fod4xkd7 99 15 the the DT cord-259669-fod4xkd7 99 16 situation situation NN cord-259669-fod4xkd7 99 17 with with IN cord-259669-fod4xkd7 99 18 human human NN cord-259669-fod4xkd7 99 19 and and CC cord-259669-fod4xkd7 99 20 mouse mouse NN cord-259669-fod4xkd7 99 21 BMHC BMHC NNP cord-259669-fod4xkd7 99 22 [ [ -LRB- cord-259669-fod4xkd7 99 23 13 13 CD cord-259669-fod4xkd7 99 24 ] ] -RRB- cord-259669-fod4xkd7 100 1 ( ( -LRB- cord-259669-fod4xkd7 100 2 Guzylack Guzylack NNP cord-259669-fod4xkd7 100 3 - - HYPH cord-259669-fod4xkd7 100 4 Piriou Piriou NNP cord-259669-fod4xkd7 100 5 and and CC cord-259669-fod4xkd7 100 6 Summerfield Summerfield NNP cord-259669-fod4xkd7 100 7 , , , cord-259669-fod4xkd7 100 8 unpublished unpublished JJ cord-259669-fod4xkd7 100 9 data datum NNS cord-259669-fod4xkd7 100 10 ) ) -RRB- cord-259669-fod4xkd7 100 11 . . . cord-259669-fod4xkd7 101 1 Furthermore furthermore RB cord-259669-fod4xkd7 101 2 , , , cord-259669-fod4xkd7 101 3 Flt3L flt3l NN cord-259669-fod4xkd7 101 4 - - HYPH cord-259669-fod4xkd7 101 5 induced induce VBN cord-259669-fod4xkd7 101 6 BMHC BMHC NNP cord-259669-fod4xkd7 101 7 - - HYPH cord-259669-fod4xkd7 101 8 derived derive VBN cord-259669-fod4xkd7 101 9 cDC cDC NNP cord-259669-fod4xkd7 101 10 phenotypically phenotypically RB cord-259669-fod4xkd7 101 11 and and CC cord-259669-fod4xkd7 101 12 functionally functionally RB cord-259669-fod4xkd7 101 13 differ differ VBP cord-259669-fod4xkd7 101 14 from from IN cord-259669-fod4xkd7 101 15 GM GM NNP cord-259669-fod4xkd7 101 16 - - HYPH cord-259669-fod4xkd7 101 17 CSF CSF NNP cord-259669-fod4xkd7 101 18 - - HYPH cord-259669-fod4xkd7 101 19 derived derive VBN cord-259669-fod4xkd7 101 20 DC DC NNP cord-259669-fod4xkd7 101 21 either either CC cord-259669-fod4xkd7 101 22 generated generate VBN cord-259669-fod4xkd7 101 23 with with IN cord-259669-fod4xkd7 101 24 monocytes monocyte NNS cord-259669-fod4xkd7 101 25 or or CC cord-259669-fod4xkd7 101 26 BMHC BMHC NNP cord-259669-fod4xkd7 101 27 . . . cord-259669-fod4xkd7 102 1 Flt3L Flt3L NNP cord-259669-fod4xkd7 102 2 induces induce VBZ cord-259669-fod4xkd7 102 3 the the DT cord-259669-fod4xkd7 102 4 differentiation differentiation NN cord-259669-fod4xkd7 102 5 of of IN cord-259669-fod4xkd7 102 6 CD14 CD14 NNP cord-259669-fod4xkd7 102 7 À à NN cord-259669-fod4xkd7 102 8 cDC cDC NNP cord-259669-fod4xkd7 102 9 which which WDT cord-259669-fod4xkd7 102 10 are be VBP cord-259669-fod4xkd7 102 11 more more RBR cord-259669-fod4xkd7 102 12 sensitive sensitive JJ cord-259669-fod4xkd7 102 13 to to IN cord-259669-fod4xkd7 102 14 stimulation stimulation NN cord-259669-fod4xkd7 102 15 by by IN cord-259669-fod4xkd7 102 16 TLR2 TLR2 NNP cord-259669-fod4xkd7 102 17 / / SYM cord-259669-fod4xkd7 102 18 TLR6 TLR6 NNP cord-259669-fod4xkd7 102 19 , , , cord-259669-fod4xkd7 102 20 TR3 TR3 NNP cord-259669-fod4xkd7 102 21 , , , cord-259669-fod4xkd7 102 22 TLR4 TLR4 NNP cord-259669-fod4xkd7 102 23 , , , cord-259669-fod4xkd7 102 24 TLR5 TLR5 NNP cord-259669-fod4xkd7 102 25 and and CC cord-259669-fod4xkd7 102 26 TLR7 TLR7 NNP cord-259669-fod4xkd7 102 27 ligands ligand NNS cord-259669-fod4xkd7 102 28 in in IN cord-259669-fod4xkd7 102 29 terms term NNS cord-259669-fod4xkd7 102 30 of of IN cord-259669-fod4xkd7 102 31 cytokine cytokine NN cord-259669-fod4xkd7 102 32 responses response NNS cord-259669-fod4xkd7 102 33 and and CC cord-259669-fod4xkd7 102 34 maturation maturation NN cord-259669-fod4xkd7 102 35 [ [ -LRB- cord-259669-fod4xkd7 102 36 38 38 CD cord-259669-fod4xkd7 102 37 ] ] -RRB- cord-259669-fod4xkd7 103 1 ( ( -LRB- cord-259669-fod4xkd7 103 2 Guzylack Guzylack NNP cord-259669-fod4xkd7 103 3 - - HYPH cord-259669-fod4xkd7 103 4 Piriou Piriou NNP cord-259669-fod4xkd7 103 5 and and CC cord-259669-fod4xkd7 103 6 Summerfield Summerfield NNP cord-259669-fod4xkd7 103 7 , , , cord-259669-fod4xkd7 103 8 unpublished unpublished JJ cord-259669-fod4xkd7 103 9 data datum NNS cord-259669-fod4xkd7 103 10 ) ) -RRB- cord-259669-fod4xkd7 103 11 . . . cord-259669-fod4xkd7 104 1 This this DT cord-259669-fod4xkd7 104 2 may may MD cord-259669-fod4xkd7 104 3 relate relate VB cord-259669-fod4xkd7 104 4 to to IN cord-259669-fod4xkd7 104 5 the the DT cord-259669-fod4xkd7 104 6 central central JJ cord-259669-fod4xkd7 104 7 role role NN cord-259669-fod4xkd7 104 8 of of IN cord-259669-fod4xkd7 104 9 Flt3L flt3l NN cord-259669-fod4xkd7 104 10 in in IN cord-259669-fod4xkd7 104 11 the the DT cord-259669-fod4xkd7 104 12 generation generation NN cord-259669-fod4xkd7 104 13 of of IN cord-259669-fod4xkd7 104 14 DC DC NNP cord-259669-fod4xkd7 104 15 from from IN cord-259669-fod4xkd7 104 16 a a DT cord-259669-fod4xkd7 104 17 clonogenic clonogenic JJ cord-259669-fod4xkd7 104 18 BMHC BMHC NNP cord-259669-fod4xkd7 104 19 DC DC NNP cord-259669-fod4xkd7 104 20 precursor precursor NN cord-259669-fod4xkd7 104 21 [ [ -LRB- cord-259669-fod4xkd7 104 22 39 39 CD cord-259669-fod4xkd7 104 23 ] ] -RRB- cord-259669-fod4xkd7 104 24 . . . cord-259669-fod4xkd7 105 1 Porcine porcine JJ cord-259669-fod4xkd7 105 2 blood blood NN cord-259669-fod4xkd7 105 3 is be VBZ cord-259669-fod4xkd7 105 4 similar similar JJ cord-259669-fod4xkd7 105 5 to to IN cord-259669-fod4xkd7 105 6 human human JJ cord-259669-fod4xkd7 105 7 blood blood NN cord-259669-fod4xkd7 105 8 in in IN cord-259669-fod4xkd7 105 9 representing represent VBG cord-259669-fod4xkd7 105 10 an an DT cord-259669-fod4xkd7 105 11 important important JJ cord-259669-fod4xkd7 105 12 source source NN cord-259669-fod4xkd7 105 13 of of IN cord-259669-fod4xkd7 105 14 APC APC NNP cord-259669-fod4xkd7 105 15 . . . cord-259669-fod4xkd7 106 1 Several several JJ cord-259669-fod4xkd7 106 2 populations population NNS cord-259669-fod4xkd7 106 3 have have VBP cord-259669-fod4xkd7 106 4 been be VBN cord-259669-fod4xkd7 106 5 identified identify VBN cord-259669-fod4xkd7 106 6 , , , cord-259669-fod4xkd7 106 7 including include VBG cord-259669-fod4xkd7 106 8 monocytes monocyte NNS cord-259669-fod4xkd7 106 9 , , , cord-259669-fod4xkd7 106 10 DC DC NNP cord-259669-fod4xkd7 106 11 precursors precursor NNS cord-259669-fod4xkd7 106 12 and and CC cord-259669-fod4xkd7 106 13 fibrocytes fibrocyte NNS cord-259669-fod4xkd7 106 14 . . . cord-259669-fod4xkd7 107 1 All all DT cord-259669-fod4xkd7 107 2 of of IN cord-259669-fod4xkd7 107 3 these these DT cord-259669-fod4xkd7 107 4 express express NNP cord-259669-fod4xkd7 107 5 CD172a CD172a NNP cord-259669-fod4xkd7 107 6 , , , cord-259669-fod4xkd7 107 7 and and CC cord-259669-fod4xkd7 107 8 in in IN cord-259669-fod4xkd7 107 9 a a DT cord-259669-fod4xkd7 107 10 model model NN cord-259669-fod4xkd7 107 11 of of IN cord-259669-fod4xkd7 107 12 antigen antigen NN cord-259669-fod4xkd7 107 13 presentation presentation NN cord-259669-fod4xkd7 107 14 of of IN cord-259669-fod4xkd7 107 15 inactivated inactivate VBN cord-259669-fod4xkd7 107 16 foot foot NN cord-259669-fod4xkd7 107 17 - - HYPH cord-259669-fod4xkd7 107 18 and and CC cord-259669-fod4xkd7 107 19 - - HYPH cord-259669-fod4xkd7 107 20 mouth mouth NN cord-259669-fod4xkd7 107 21 disease disease NN cord-259669-fod4xkd7 107 22 virus virus NN cord-259669-fod4xkd7 107 23 ( ( -LRB- cord-259669-fod4xkd7 107 24 FMDV FMDV NNP cord-259669-fod4xkd7 107 25 ) ) -RRB- cord-259669-fod4xkd7 107 26 to to IN cord-259669-fod4xkd7 107 27 T T NNP cord-259669-fod4xkd7 107 28 lymphocytes lymphocyte NNS cord-259669-fod4xkd7 107 29 the the DT cord-259669-fod4xkd7 107 30 activation activation NN cord-259669-fod4xkd7 107 31 was be VBD cord-259669-fod4xkd7 107 32 dependent dependent JJ cord-259669-fod4xkd7 107 33 on on IN cord-259669-fod4xkd7 107 34 the the DT cord-259669-fod4xkd7 107 35 presence presence NN cord-259669-fod4xkd7 107 36 of of IN cord-259669-fod4xkd7 107 37 CD172a cd172a NN cord-259669-fod4xkd7 107 38 + + CC cord-259669-fod4xkd7 107 39 cells cell NNS cord-259669-fod4xkd7 107 40 [ [ -LRB- cord-259669-fod4xkd7 107 41 40 40 CD cord-259669-fod4xkd7 107 42 , , , cord-259669-fod4xkd7 107 43 41 41 CD cord-259669-fod4xkd7 107 44 ] ] -RRB- cord-259669-fod4xkd7 107 45 . . . cord-259669-fod4xkd7 108 1 Similar similar JJ cord-259669-fod4xkd7 108 2 results result NNS cord-259669-fod4xkd7 108 3 were be VBD cord-259669-fod4xkd7 108 4 also also RB cord-259669-fod4xkd7 108 5 obtained obtain VBN cord-259669-fod4xkd7 108 6 with with IN cord-259669-fod4xkd7 108 7 classical classical JJ cord-259669-fod4xkd7 108 8 swine swine NN cord-259669-fod4xkd7 108 9 fever fever NN cord-259669-fod4xkd7 108 10 virus virus NN cord-259669-fod4xkd7 108 11 ( ( -LRB- cord-259669-fod4xkd7 108 12 CSFV CSFV NNP cord-259669-fod4xkd7 108 13 ) ) -RRB- cord-259669-fod4xkd7 108 14 and and CC cord-259669-fod4xkd7 108 15 protein protein NN cord-259669-fod4xkd7 108 16 antigens antigen NNS cord-259669-fod4xkd7 108 17 derived derive VBN cord-259669-fod4xkd7 108 18 from from IN cord-259669-fod4xkd7 108 19 this this DT cord-259669-fod4xkd7 108 20 virus virus NN cord-259669-fod4xkd7 108 21 [ [ -LRB- cord-259669-fod4xkd7 108 22 25 25 CD cord-259669-fod4xkd7 108 23 , , , cord-259669-fod4xkd7 108 24 42 42 CD cord-259669-fod4xkd7 108 25 ] ] -RRB- cord-259669-fod4xkd7 108 26 , , , cord-259669-fod4xkd7 108 27 as as RB cord-259669-fod4xkd7 108 28 well well RB cord-259669-fod4xkd7 108 29 as as IN cord-259669-fod4xkd7 108 30 with with IN cord-259669-fod4xkd7 108 31 tetanus tetanus NN cord-259669-fod4xkd7 108 32 toxoid toxoid NN cord-259669-fod4xkd7 108 33 [ [ -LRB- cord-259669-fod4xkd7 108 34 43 43 CD cord-259669-fod4xkd7 108 35 ] ] -RRB- cord-259669-fod4xkd7 108 36 . . . cord-259669-fod4xkd7 109 1 Separating separate VBG cord-259669-fod4xkd7 109 2 the the DT cord-259669-fod4xkd7 109 3 CD172a CD172a NNP cord-259669-fod4xkd7 109 4 + + CC cord-259669-fod4xkd7 109 5 PBMC PBMC NNP cord-259669-fod4xkd7 109 6 into into IN cord-259669-fod4xkd7 109 7 a a DT cord-259669-fod4xkd7 109 8 major major JJ cord-259669-fod4xkd7 109 9 population population NN cord-259669-fod4xkd7 109 10 of of IN cord-259669-fod4xkd7 109 11 CD14 CD14 NNP cord-259669-fod4xkd7 109 12 + + CC cord-259669-fod4xkd7 109 13 monocytes monocyte NNS cord-259669-fod4xkd7 109 14 and and CC cord-259669-fod4xkd7 109 15 a a DT cord-259669-fod4xkd7 109 16 minor minor JJ cord-259669-fod4xkd7 109 17 population population NN cord-259669-fod4xkd7 109 18 of of IN cord-259669-fod4xkd7 109 19 CD14 CD14 NNP cord-259669-fod4xkd7 109 20 À à NN cord-259669-fod4xkd7 109 21 cells cell NNS cord-259669-fod4xkd7 109 22 showed show VBD cord-259669-fod4xkd7 109 23 that that IN cord-259669-fod4xkd7 109 24 the the DT cord-259669-fod4xkd7 109 25 latter latter NN cord-259669-fod4xkd7 109 26 contained contain VBD cord-259669-fod4xkd7 109 27 the the DT cord-259669-fod4xkd7 109 28 CD4 CD4 NNP cord-259669-fod4xkd7 109 29 À à IN cord-259669-fod4xkd7 109 30 blood blood NN cord-259669-fod4xkd7 109 31 cDC cDC NNS cord-259669-fod4xkd7 109 32 along along RP cord-259669-fod4xkd7 109 33 with with IN cord-259669-fod4xkd7 109 34 the the DT cord-259669-fod4xkd7 109 35 CD4 CD4 NNP cord-259669-fod4xkd7 109 36 + + CC cord-259669-fod4xkd7 109 37 pDC pDC NNP cord-259669-fod4xkd7 110 1 ( ( -LRB- cord-259669-fod4xkd7 110 2 Table table NN cord-259669-fod4xkd7 110 3 1 1 CD cord-259669-fod4xkd7 110 4 ; ; : cord-259669-fod4xkd7 110 5 [ [ -LRB- cord-259669-fod4xkd7 110 6 40 40 CD cord-259669-fod4xkd7 110 7 ] ] -RRB- cord-259669-fod4xkd7 110 8 ) ) -RRB- cord-259669-fod4xkd7 110 9 . . . cord-259669-fod4xkd7 111 1 It -PRON- PRP cord-259669-fod4xkd7 111 2 is be VBZ cord-259669-fod4xkd7 111 3 notable notable JJ cord-259669-fod4xkd7 111 4 that that IN cord-259669-fod4xkd7 111 5 although although IN cord-259669-fod4xkd7 111 6 the the DT cord-259669-fod4xkd7 111 7 blood blood NN cord-259669-fod4xkd7 111 8 cDC cDC NNS cord-259669-fod4xkd7 111 9 and and CC cord-259669-fod4xkd7 111 10 pDC pDC NNP cord-259669-fod4xkd7 111 11 differ differ VBP cord-259669-fod4xkd7 111 12 phenotypically phenotypically RB cord-259669-fod4xkd7 111 13 ( ( -LRB- cord-259669-fod4xkd7 111 14 CD4 CD4 NNP cord-259669-fod4xkd7 111 15 expression expression NN cord-259669-fod4xkd7 111 16 ) ) -RRB- cord-259669-fod4xkd7 111 17 , , , cord-259669-fod4xkd7 111 18 they -PRON- PRP cord-259669-fod4xkd7 111 19 are be VBP cord-259669-fod4xkd7 111 20 similar similar JJ cord-259669-fod4xkd7 111 21 in in IN cord-259669-fod4xkd7 111 22 their -PRON- PRP$ cord-259669-fod4xkd7 111 23 lack lack NN cord-259669-fod4xkd7 111 24 of of IN cord-259669-fod4xkd7 111 25 CD14 CD14 NNP cord-259669-fod4xkd7 111 26 expression expression NN cord-259669-fod4xkd7 111 27 , , , cord-259669-fod4xkd7 111 28 which which WDT cord-259669-fod4xkd7 111 29 distinguishes distinguish VBZ cord-259669-fod4xkd7 111 30 them -PRON- PRP cord-259669-fod4xkd7 111 31 from from IN cord-259669-fod4xkd7 111 32 in in IN cord-259669-fod4xkd7 111 33 vitro vitro FW cord-259669-fod4xkd7 111 34 generated generate VBN cord-259669-fod4xkd7 111 35 MoDC MoDC NNP cord-259669-fod4xkd7 111 36 . . . cord-259669-fod4xkd7 112 1 However however RB cord-259669-fod4xkd7 112 2 , , , cord-259669-fod4xkd7 112 3 this this DT cord-259669-fod4xkd7 112 4 simple simple JJ cord-259669-fod4xkd7 112 5 discrimination discrimination NN cord-259669-fod4xkd7 112 6 is be VBZ cord-259669-fod4xkd7 112 7 not not RB cord-259669-fod4xkd7 112 8 absolute absolute JJ cord-259669-fod4xkd7 112 9 . . . cord-259669-fod4xkd7 113 1 The the DT cord-259669-fod4xkd7 113 2 composition composition NN cord-259669-fod4xkd7 113 3 of of IN cord-259669-fod4xkd7 113 4 blood blood NN cord-259669-fod4xkd7 113 5 APC APC NNP cord-259669-fod4xkd7 113 6 is be VBZ cord-259669-fod4xkd7 113 7 more more RBR cord-259669-fod4xkd7 113 8 complex complex JJ cord-259669-fod4xkd7 113 9 , , , cord-259669-fod4xkd7 113 10 as as IN cord-259669-fod4xkd7 113 11 summarized summarize VBN cord-259669-fod4xkd7 113 12 in in IN cord-259669-fod4xkd7 113 13 Fig Fig NNP cord-259669-fod4xkd7 113 14 . . . cord-259669-fod4xkd7 114 1 1 1 LS cord-259669-fod4xkd7 114 2 . . . cord-259669-fod4xkd7 115 1 Accordingly accordingly RB cord-259669-fod4xkd7 115 2 , , , cord-259669-fod4xkd7 115 3 it -PRON- PRP cord-259669-fod4xkd7 115 4 is be VBZ cord-259669-fod4xkd7 115 5 necessary necessary JJ cord-259669-fod4xkd7 115 6 to to TO cord-259669-fod4xkd7 115 7 appreciate appreciate VB cord-259669-fod4xkd7 115 8 each each DT cord-259669-fod4xkd7 115 9 of of IN cord-259669-fod4xkd7 115 10 the the DT cord-259669-fod4xkd7 115 11 blood blood NN cord-259669-fod4xkd7 115 12 APC APC NNP cord-259669-fod4xkd7 115 13 in in IN cord-259669-fod4xkd7 115 14 turn turn NN cord-259669-fod4xkd7 115 15 , , , cord-259669-fod4xkd7 115 16 to to TO cord-259669-fod4xkd7 115 17 obtain obtain VB cord-259669-fod4xkd7 115 18 a a DT cord-259669-fod4xkd7 115 19 better well JJR cord-259669-fod4xkd7 115 20 understanding understanding NN cord-259669-fod4xkd7 115 21 of of IN cord-259669-fod4xkd7 115 22 their -PRON- PRP$ cord-259669-fod4xkd7 115 23 roles role NNS cord-259669-fod4xkd7 115 24 and and CC cord-259669-fod4xkd7 115 25 function function VB cord-259669-fod4xkd7 115 26 in in IN cord-259669-fod4xkd7 115 27 immune immune JJ cord-259669-fod4xkd7 115 28 defences defence NNS cord-259669-fod4xkd7 115 29 . . . cord-259669-fod4xkd7 116 1 Porcine porcine JJ cord-259669-fod4xkd7 116 2 blood blood NN cord-259669-fod4xkd7 116 3 carries carry VBZ cord-259669-fod4xkd7 116 4 a a DT cord-259669-fod4xkd7 116 5 subpopulation subpopulation NN cord-259669-fod4xkd7 116 6 of of IN cord-259669-fod4xkd7 116 7 PBMC PBMC NNP cord-259669-fod4xkd7 116 8 , , , cord-259669-fod4xkd7 117 1 which which WDT cord-259669-fod4xkd7 117 2 are be VBP cord-259669-fod4xkd7 117 3 CD172a cd172a NN cord-259669-fod4xkd7 117 4 + + CD cord-259669-fod4xkd7 118 1 CD4 CD4 NNP cord-259669-fod4xkd7 118 2 À À NNP cord-259669-fod4xkd7 118 3 CD14 CD14 NNP cord-259669-fod4xkd7 118 4 À à NN cord-259669-fod4xkd7 118 5 , , , cord-259669-fod4xkd7 118 6 with with IN cord-259669-fod4xkd7 118 7 characteristics characteristic NNS cord-259669-fod4xkd7 118 8 of of IN cord-259669-fod4xkd7 118 9 cDC cdc JJ cord-259669-fod4xkd7 118 10 - - HYPH cord-259669-fod4xkd7 118 11 high high JJ cord-259669-fod4xkd7 118 12 levels level NNS cord-259669-fod4xkd7 118 13 of of IN cord-259669-fod4xkd7 118 14 MHC MHC NNP cord-259669-fod4xkd7 118 15 class class NN cord-259669-fod4xkd7 118 16 II II NNP cord-259669-fod4xkd7 118 17 and and CC cord-259669-fod4xkd7 118 18 CD80/86 cd80/86 CD cord-259669-fod4xkd7 119 1 ( ( -LRB- cord-259669-fod4xkd7 119 2 Fig Fig NNP cord-259669-fod4xkd7 119 3 . . NNP cord-259669-fod4xkd7 119 4 1 1 CD cord-259669-fod4xkd7 119 5 and and CC cord-259669-fod4xkd7 119 6 Table Table NNP cord-259669-fod4xkd7 119 7 1 1 CD cord-259669-fod4xkd7 119 8 ) ) -RRB- cord-259669-fod4xkd7 119 9 , , , cord-259669-fod4xkd7 119 10 nonadherence nonadherence NN cord-259669-fod4xkd7 119 11 and and CC cord-259669-fod4xkd7 119 12 potent potent JJ cord-259669-fod4xkd7 119 13 T t NN cord-259669-fod4xkd7 119 14 - - HYPH cord-259669-fod4xkd7 119 15 cell cell NN cord-259669-fod4xkd7 119 16 stimulatory stimulatory JJ cord-259669-fod4xkd7 119 17 capacity capacity NN cord-259669-fod4xkd7 119 18 [ [ -LRB- cord-259669-fod4xkd7 119 19 40 40 CD cord-259669-fod4xkd7 119 20 ] ] -RRB- cord-259669-fod4xkd7 119 21 . . . cord-259669-fod4xkd7 120 1 After after IN cord-259669-fod4xkd7 120 2 in in FW cord-259669-fod4xkd7 120 3 vitro vitro FW cord-259669-fod4xkd7 120 4 culture culture NN cord-259669-fod4xkd7 120 5 , , , cord-259669-fod4xkd7 120 6 these these DT cord-259669-fod4xkd7 120 7 cells cell NNS cord-259669-fod4xkd7 120 8 strongly strongly RB cord-259669-fod4xkd7 120 9 up up RB cord-259669-fod4xkd7 120 10 - - HYPH cord-259669-fod4xkd7 120 11 regulate regulate VB cord-259669-fod4xkd7 120 12 MHC MHC NNP cord-259669-fod4xkd7 120 13 and and CC cord-259669-fod4xkd7 120 14 co co JJ cord-259669-fod4xkd7 120 15 - - JJ cord-259669-fod4xkd7 120 16 stimulatory stimulatory JJ cord-259669-fod4xkd7 120 17 molecules molecule NNS cord-259669-fod4xkd7 120 18 , , , cord-259669-fod4xkd7 120 19 and and CC cord-259669-fod4xkd7 120 20 their -PRON- PRP$ cord-259669-fod4xkd7 120 21 dendritic dendritic JJ cord-259669-fod4xkd7 120 22 morphology morphology NN cord-259669-fod4xkd7 120 23 becomes become VBZ cord-259669-fod4xkd7 120 24 clear clear JJ cord-259669-fod4xkd7 120 25 . . . cord-259669-fod4xkd7 121 1 Based base VBN cord-259669-fod4xkd7 121 2 on on IN cord-259669-fod4xkd7 121 3 these these DT cord-259669-fod4xkd7 121 4 characteristics characteristic NNS cord-259669-fod4xkd7 121 5 , , , cord-259669-fod4xkd7 121 6 we -PRON- PRP cord-259669-fod4xkd7 121 7 have have VBP cord-259669-fod4xkd7 121 8 proposed propose VBN cord-259669-fod4xkd7 121 9 that that IN cord-259669-fod4xkd7 121 10 this this DT cord-259669-fod4xkd7 121 11 population population NN cord-259669-fod4xkd7 121 12 contains contain VBZ cord-259669-fod4xkd7 121 13 the the DT cord-259669-fod4xkd7 121 14 precursors precursor NNS cord-259669-fod4xkd7 121 15 of of IN cord-259669-fod4xkd7 121 16 blood blood NN cord-259669-fod4xkd7 121 17 cDC cDC NNS cord-259669-fod4xkd7 121 18 . . . cord-259669-fod4xkd7 122 1 These these DT cord-259669-fod4xkd7 122 2 cells cell NNS cord-259669-fod4xkd7 122 3 have have VBP cord-259669-fod4xkd7 122 4 variable variable JJ cord-259669-fod4xkd7 122 5 expression expression NN cord-259669-fod4xkd7 122 6 of of IN cord-259669-fod4xkd7 122 7 CD1 CD1 NNP cord-259669-fod4xkd7 122 8 and and CC cord-259669-fod4xkd7 122 9 CD16 CD16 NNP cord-259669-fod4xkd7 122 10 and and CC cord-259669-fod4xkd7 122 11 can can MD cord-259669-fod4xkd7 122 12 be be VB cord-259669-fod4xkd7 122 13 differentiated differentiate VBN cord-259669-fod4xkd7 122 14 from from IN cord-259669-fod4xkd7 122 15 monocytes monocyte NNS cord-259669-fod4xkd7 122 16 by by IN cord-259669-fod4xkd7 122 17 lower low JJR cord-259669-fod4xkd7 122 18 levels level NNS cord-259669-fod4xkd7 122 19 of of IN cord-259669-fod4xkd7 122 20 CD172a cd172a NN cord-259669-fod4xkd7 123 1 ( ( -LRB- cord-259669-fod4xkd7 123 2 Fig Fig NNP cord-259669-fod4xkd7 123 3 . . NNP cord-259669-fod4xkd7 123 4 1 1 CD cord-259669-fod4xkd7 123 5 and and CC cord-259669-fod4xkd7 123 6 [ [ -LRB- cord-259669-fod4xkd7 123 7 40 40 CD cord-259669-fod4xkd7 123 8 ] ] -RRB- cord-259669-fod4xkd7 123 9 ) ) -RRB- cord-259669-fod4xkd7 123 10 . . . cord-259669-fod4xkd7 124 1 Although although IN cord-259669-fod4xkd7 124 2 the the DT cord-259669-fod4xkd7 124 3 majority majority NN cord-259669-fod4xkd7 124 4 of of IN cord-259669-fod4xkd7 124 5 porcine porcine JJ cord-259669-fod4xkd7 124 6 blood blood NN cord-259669-fod4xkd7 124 7 monocytes monocyte NNS cord-259669-fod4xkd7 124 8 are be VBP cord-259669-fod4xkd7 124 9 CD1 CD1 NNP cord-259669-fod4xkd7 124 10 À À NNP cord-259669-fod4xkd7 124 11 CD4 CD4 NNP cord-259669-fod4xkd7 124 12 À À NNP cord-259669-fod4xkd7 124 13 CD14 CD14 NNP cord-259669-fod4xkd7 124 14 + + CC cord-259669-fod4xkd7 124 15 CD16 CD16 NNP cord-259669-fod4xkd7 125 1 + + CC cord-259669-fod4xkd7 126 1 CD172a CD172a NNP cord-259669-fod4xkd7 127 1 + + CC cord-259669-fod4xkd7 128 1 ( ( -LRB- cord-259669-fod4xkd7 128 2 Table table NN cord-259669-fod4xkd7 128 3 1 1 CD cord-259669-fod4xkd7 128 4 and and CC cord-259669-fod4xkd7 128 5 Fig Fig NNP cord-259669-fod4xkd7 128 6 . . NNP cord-259669-fod4xkd7 128 7 1 1 CD cord-259669-fod4xkd7 128 8 ) ) -RRB- cord-259669-fod4xkd7 128 9 , , , cord-259669-fod4xkd7 128 10 a a DT cord-259669-fod4xkd7 128 11 detailed detailed JJ cord-259669-fod4xkd7 128 12 analysis analysis NN cord-259669-fod4xkd7 128 13 of of IN cord-259669-fod4xkd7 128 14 the the DT cord-259669-fod4xkd7 128 15 monocytic monocytic JJ cord-259669-fod4xkd7 128 16 population population NN cord-259669-fod4xkd7 128 17 has have VBZ cord-259669-fod4xkd7 128 18 identified identify VBN cord-259669-fod4xkd7 128 19 at at IN cord-259669-fod4xkd7 128 20 least least JJS cord-259669-fod4xkd7 128 21 four four CD cord-259669-fod4xkd7 128 22 subsets subset NNS cord-259669-fod4xkd7 128 23 based base VBN cord-259669-fod4xkd7 128 24 on on IN cord-259669-fod4xkd7 128 25 CD14 CD14 NNP cord-259669-fod4xkd7 128 26 and and CC cord-259669-fod4xkd7 128 27 CD163 CD163 NNP cord-259669-fod4xkd7 128 28 [ [ -LRB- cord-259669-fod4xkd7 128 29 44 44 CD cord-259669-fod4xkd7 128 30 ] ] -RRB- cord-259669-fod4xkd7 128 31 . . . cord-259669-fod4xkd7 129 1 It -PRON- PRP cord-259669-fod4xkd7 129 2 is be VBZ cord-259669-fod4xkd7 129 3 currently currently RB cord-259669-fod4xkd7 129 4 not not RB cord-259669-fod4xkd7 129 5 clear clear JJ cord-259669-fod4xkd7 129 6 how how WRB cord-259669-fod4xkd7 129 7 the the DT cord-259669-fod4xkd7 129 8 blood blood NN cord-259669-fod4xkd7 129 9 cDC cdc VBP cord-259669-fod4xkd7 129 10 population population NN cord-259669-fod4xkd7 129 11 phenotypically phenotypically RB cord-259669-fod4xkd7 129 12 defined define VBN cord-259669-fod4xkd7 129 13 as as IN cord-259669-fod4xkd7 129 14 CD172a+CD4 cd172a+cd4 CD cord-259669-fod4xkd7 129 15 À à NN cord-259669-fod4xkd7 129 16 CD14 CD14 NNP cord-259669-fod4xkd7 129 17 À à NN cord-259669-fod4xkd7 129 18 cell cell NN cord-259669-fod4xkd7 129 19 relates relate VBZ cord-259669-fod4xkd7 129 20 the the DT cord-259669-fod4xkd7 129 21 CD14 CD14 NNP cord-259669-fod4xkd7 129 22 À À NNP cord-259669-fod4xkd7 129 23 CD163 CD163 NNP cord-259669-fod4xkd7 129 24 + + CC cord-259669-fod4xkd7 129 25 monocytic monocytic JJ cord-259669-fod4xkd7 129 26 cell cell NN cord-259669-fod4xkd7 129 27 . . . cord-259669-fod4xkd7 130 1 CD163 CD163 NNP cord-259669-fod4xkd7 130 2 is be VBZ cord-259669-fod4xkd7 130 3 proposed propose VBN cord-259669-fod4xkd7 130 4 as as IN cord-259669-fod4xkd7 130 5 a a DT cord-259669-fod4xkd7 130 6 macrophage macrophage NN cord-259669-fod4xkd7 130 7 marker marker NN cord-259669-fod4xkd7 130 8 , , , cord-259669-fod4xkd7 130 9 which which WDT cord-259669-fod4xkd7 130 10 is be VBZ cord-259669-fod4xkd7 130 11 up up RB cord-259669-fod4xkd7 130 12 - - HYPH cord-259669-fod4xkd7 130 13 regulated regulate VBN cord-259669-fod4xkd7 130 14 during during IN cord-259669-fod4xkd7 130 15 the the DT cord-259669-fod4xkd7 130 16 differentiation differentiation NN cord-259669-fod4xkd7 130 17 of of IN cord-259669-fod4xkd7 130 18 monocytes monocyte NNS cord-259669-fod4xkd7 130 19 to to TO cord-259669-fod4xkd7 130 20 macrophages macrophage NNS cord-259669-fod4xkd7 130 21 [ [ -LRB- cord-259669-fod4xkd7 130 22 45 45 CD cord-259669-fod4xkd7 130 23 ] ] -RRB- cord-259669-fod4xkd7 130 24 but but CC cord-259669-fod4xkd7 130 25 down down RB cord-259669-fod4xkd7 130 26 - - HYPH cord-259669-fod4xkd7 130 27 regulated regulate VBN cord-259669-fod4xkd7 130 28 if if IN cord-259669-fod4xkd7 130 29 monocytes monocyte NNS cord-259669-fod4xkd7 130 30 are be VBP cord-259669-fod4xkd7 130 31 induced induce VBN cord-259669-fod4xkd7 130 32 to to TO cord-259669-fod4xkd7 130 33 differentiate differentiate VB cord-259669-fod4xkd7 130 34 into into IN cord-259669-fod4xkd7 130 35 DC DC NNP cord-259669-fod4xkd7 130 36 by by IN cord-259669-fod4xkd7 130 37 GM GM NNP cord-259669-fod4xkd7 130 38 - - HYPH cord-259669-fod4xkd7 130 39 CSF CSF NNP cord-259669-fod4xkd7 130 40 / / , cord-259669-fod4xkd7 130 41 IL-4 IL-4 NNP cord-259669-fod4xkd7 130 42 [ [ -LRB- cord-259669-fod4xkd7 130 43 30 30 CD cord-259669-fod4xkd7 130 44 ] ] -RRB- cord-259669-fod4xkd7 130 45 . . . cord-259669-fod4xkd7 131 1 This this DT cord-259669-fod4xkd7 131 2 would would MD cord-259669-fod4xkd7 131 3 argue argue VB cord-259669-fod4xkd7 131 4 for for IN cord-259669-fod4xkd7 131 5 two two CD cord-259669-fod4xkd7 131 6 distinct distinct JJ cord-259669-fod4xkd7 131 7 subsets subset NNS cord-259669-fod4xkd7 131 8 of of IN cord-259669-fod4xkd7 131 9 cells cell NNS cord-259669-fod4xkd7 131 10 , , , cord-259669-fod4xkd7 131 11 a a DT cord-259669-fod4xkd7 131 12 point point NN cord-259669-fod4xkd7 131 13 which which WDT cord-259669-fod4xkd7 131 14 is be VBZ cord-259669-fod4xkd7 131 15 not not RB cord-259669-fod4xkd7 131 16 surprising surprising JJ cord-259669-fod4xkd7 131 17 considering consider VBG cord-259669-fod4xkd7 131 18 the the DT cord-259669-fod4xkd7 131 19 diversity diversity NN cord-259669-fod4xkd7 131 20 of of IN cord-259669-fod4xkd7 131 21 the the DT cord-259669-fod4xkd7 131 22 DC DC NNP cord-259669-fod4xkd7 131 23 family family NN cord-259669-fod4xkd7 131 24 , , , cord-259669-fod4xkd7 131 25 but but CC cord-259669-fod4xkd7 131 26 still still RB cord-259669-fod4xkd7 131 27 requires require VBZ cord-259669-fod4xkd7 131 28 further further JJ cord-259669-fod4xkd7 131 29 clarification clarification NN cord-259669-fod4xkd7 131 30 ( ( -LRB- cord-259669-fod4xkd7 131 31 see see VB cord-259669-fod4xkd7 131 32 also also RB cord-259669-fod4xkd7 131 33 Dominguez Dominguez NNP cord-259669-fod4xkd7 131 34 et et NNP cord-259669-fod4xkd7 131 35 al al NNP cord-259669-fod4xkd7 131 36 . . . cord-259669-fod4xkd7 132 1 , , , cord-259669-fod4xkd7 132 2 this this DT cord-259669-fod4xkd7 132 3 volume volume NN cord-259669-fod4xkd7 132 4 ) ) -RRB- cord-259669-fod4xkd7 132 5 . . . cord-259669-fod4xkd7 133 1 Based base VBN cord-259669-fod4xkd7 133 2 on on IN cord-259669-fod4xkd7 133 3 the the DT cord-259669-fod4xkd7 133 4 frequent frequent JJ cord-259669-fod4xkd7 133 5 expression expression NN cord-259669-fod4xkd7 133 6 of of IN cord-259669-fod4xkd7 133 7 the the DT cord-259669-fod4xkd7 133 8 CD11R1 CD11R1 NNP cord-259669-fod4xkd7 133 9 marker marker NN cord-259669-fod4xkd7 133 10 on on IN cord-259669-fod4xkd7 133 11 DC DC NNP cord-259669-fod4xkd7 133 12 in in IN cord-259669-fod4xkd7 133 13 the the DT cord-259669-fod4xkd7 133 14 mucosa mucosa JJ cord-259669-fod4xkd7 133 15 [ [ -LRB- cord-259669-fod4xkd7 133 16 46 46 CD cord-259669-fod4xkd7 133 17 , , , cord-259669-fod4xkd7 133 18 47 47 CD cord-259669-fod4xkd7 133 19 ] ] -RRB- cord-259669-fod4xkd7 133 20 , , , cord-259669-fod4xkd7 133 21 this this DT cord-259669-fod4xkd7 133 22 marker marker NN cord-259669-fod4xkd7 133 23 has have VBZ cord-259669-fod4xkd7 133 24 also also RB cord-259669-fod4xkd7 133 25 been be VBN cord-259669-fod4xkd7 133 26 proposed propose VBN cord-259669-fod4xkd7 133 27 for for IN cord-259669-fod4xkd7 133 28 identification identification NN cord-259669-fod4xkd7 133 29 of of IN cord-259669-fod4xkd7 133 30 cDC cDC NNS cord-259669-fod4xkd7 133 31 in in IN cord-259669-fod4xkd7 133 32 the the DT cord-259669-fod4xkd7 133 33 blood blood NN cord-259669-fod4xkd7 133 34 and and CC cord-259669-fod4xkd7 133 35 other other JJ cord-259669-fod4xkd7 133 36 organs organ NNS cord-259669-fod4xkd7 133 37 as as IN cord-259669-fod4xkd7 133 38 a a DT cord-259669-fod4xkd7 133 39 CD172a cd172a NN cord-259669-fod4xkd7 134 1 + + CC cord-259669-fod4xkd7 135 1 CD11R1 CD11R1 NNP cord-259669-fod4xkd7 135 2 + + CC cord-259669-fod4xkd7 135 3 population population NN cord-259669-fod4xkd7 135 4 [ [ -LRB- cord-259669-fod4xkd7 135 5 48 48 CD cord-259669-fod4xkd7 135 6 , , , cord-259669-fod4xkd7 135 7 49 49 CD cord-259669-fod4xkd7 135 8 ] ] -RRB- cord-259669-fod4xkd7 135 9 . . . cord-259669-fod4xkd7 136 1 However however RB cord-259669-fod4xkd7 136 2 , , , cord-259669-fod4xkd7 136 3 this this DT cord-259669-fod4xkd7 136 4 definition definition NN cord-259669-fod4xkd7 136 5 may may MD cord-259669-fod4xkd7 136 6 not not RB cord-259669-fod4xkd7 136 7 be be VB cord-259669-fod4xkd7 136 8 sufficient sufficient JJ cord-259669-fod4xkd7 136 9 as as IN cord-259669-fod4xkd7 136 10 no no DT cord-259669-fod4xkd7 136 11 functional functional JJ cord-259669-fod4xkd7 136 12 studies study NNS cord-259669-fod4xkd7 136 13 have have VBP cord-259669-fod4xkd7 136 14 been be VBN cord-259669-fod4xkd7 136 15 described describe VBN cord-259669-fod4xkd7 136 16 , , , cord-259669-fod4xkd7 136 17 and and CC cord-259669-fod4xkd7 136 18 it -PRON- PRP cord-259669-fod4xkd7 136 19 does do VBZ cord-259669-fod4xkd7 136 20 not not RB cord-259669-fod4xkd7 136 21 consider consider VB cord-259669-fod4xkd7 136 22 that that IN cord-259669-fod4xkd7 136 23 a a DT cord-259669-fod4xkd7 136 24 subset subset NN cord-259669-fod4xkd7 136 25 of of IN cord-259669-fod4xkd7 136 26 monocytes monocyte NNS cord-259669-fod4xkd7 136 27 also also RB cord-259669-fod4xkd7 136 28 express express VBP cord-259669-fod4xkd7 136 29 CD11R1 CD11R1 NNP cord-259669-fod4xkd7 136 30 [ [ -LRB- cord-259669-fod4xkd7 136 31 50 50 CD cord-259669-fod4xkd7 136 32 ] ] -RRB- cord-259669-fod4xkd7 136 33 . . . cord-259669-fod4xkd7 137 1 Although although IN cord-259669-fod4xkd7 137 2 several several JJ cord-259669-fod4xkd7 137 3 cell cell NN cord-259669-fod4xkd7 137 4 types type NNS cord-259669-fod4xkd7 137 5 can can MD cord-259669-fod4xkd7 137 6 produce produce VB cord-259669-fod4xkd7 137 7 type type NN cord-259669-fod4xkd7 138 1 I -PRON- PRP cord-259669-fod4xkd7 138 2 IFN IFN NNP cord-259669-fod4xkd7 138 3 upon upon IN cord-259669-fod4xkd7 138 4 viral viral JJ cord-259669-fod4xkd7 138 5 infection infection NN cord-259669-fod4xkd7 138 6 , , , cord-259669-fod4xkd7 138 7 pDC pDC NNP cord-259669-fod4xkd7 138 8 are be VBP cord-259669-fod4xkd7 138 9 particularly particularly RB cord-259669-fod4xkd7 138 10 adept adept JJ cord-259669-fod4xkd7 138 11 at at IN cord-259669-fod4xkd7 138 12 secreting secrete VBG cord-259669-fod4xkd7 138 13 very very RB cord-259669-fod4xkd7 138 14 high high JJ cord-259669-fod4xkd7 138 15 levels level NNS cord-259669-fod4xkd7 138 16 of of IN cord-259669-fod4xkd7 138 17 type type NN cord-259669-fod4xkd7 138 18 I -PRON- PRP cord-259669-fod4xkd7 138 19 IFNs ifns VBP cord-259669-fod4xkd7 138 20 [ [ -LRB- cord-259669-fod4xkd7 138 21 13 13 CD cord-259669-fod4xkd7 138 22 ] ] -RRB- cord-259669-fod4xkd7 138 23 . . . cord-259669-fod4xkd7 139 1 Representing represent VBG cord-259669-fod4xkd7 139 2 less less JJR cord-259669-fod4xkd7 139 3 of of IN cord-259669-fod4xkd7 139 4 0.5 0.5 CD cord-259669-fod4xkd7 139 5 % % NN cord-259669-fod4xkd7 139 6 of of IN cord-259669-fod4xkd7 139 7 the the DT cord-259669-fod4xkd7 139 8 PBMC PBMC NNP cord-259669-fod4xkd7 139 9 [ [ -LRB- cord-259669-fod4xkd7 139 10 40 40 CD cord-259669-fod4xkd7 139 11 ] ] -RRB- cord-259669-fod4xkd7 139 12 , , , cord-259669-fod4xkd7 139 13 porcine porcine NNP cord-259669-fod4xkd7 139 14 pDC pDC NNP cord-259669-fod4xkd7 139 15 were be VBD cord-259669-fod4xkd7 139 16 identified identify VBN cord-259669-fod4xkd7 139 17 through through IN cord-259669-fod4xkd7 139 18 their -PRON- PRP$ cord-259669-fod4xkd7 139 19 IFN IFN NNP cord-259669-fod4xkd7 139 20 - - : cord-259669-fod4xkd7 139 21 a a DT cord-259669-fod4xkd7 139 22 responses response NNS cord-259669-fod4xkd7 139 23 to to IN cord-259669-fod4xkd7 139 24 transmissible transmissible JJ cord-259669-fod4xkd7 139 25 gastroenteritis gastroenteritis NN cord-259669-fod4xkd7 139 26 virus virus NN cord-259669-fod4xkd7 139 27 ( ( -LRB- cord-259669-fod4xkd7 139 28 TGEV TGEV NNP cord-259669-fod4xkd7 139 29 ) ) -RRB- cord-259669-fod4xkd7 139 30 [ [ -LRB- cord-259669-fod4xkd7 139 31 51 51 CD cord-259669-fod4xkd7 139 32 ] ] -RRB- cord-259669-fod4xkd7 139 33 . . . cord-259669-fod4xkd7 140 1 Charley Charley NNP cord-259669-fod4xkd7 140 2 and and CC cord-259669-fod4xkd7 140 3 Lavenant Lavenant NNP cord-259669-fod4xkd7 140 4 [ [ -LRB- cord-259669-fod4xkd7 140 5 51 51 CD cord-259669-fod4xkd7 140 6 ] ] -RRB- cord-259669-fod4xkd7 140 7 originally originally RB cord-259669-fod4xkd7 140 8 described describe VBD cord-259669-fod4xkd7 140 9 them -PRON- PRP cord-259669-fod4xkd7 140 10 as as IN cord-259669-fod4xkd7 140 11 being be VBG cord-259669-fod4xkd7 140 12 non non JJ cord-259669-fod4xkd7 140 13 - - JJ cord-259669-fod4xkd7 140 14 adherent adherent JJ cord-259669-fod4xkd7 140 15 , , , cord-259669-fod4xkd7 140 16 non non JJ cord-259669-fod4xkd7 140 17 - - JJ cord-259669-fod4xkd7 140 18 T t JJ cord-259669-fod4xkd7 140 19 , , , cord-259669-fod4xkd7 140 20 non non JJ cord-259669-fod4xkd7 140 21 - - NN cord-259669-fod4xkd7 140 22 B b JJ cord-259669-fod4xkd7 140 23 , , , cord-259669-fod4xkd7 140 24 CD4 CD4 NNP cord-259669-fod4xkd7 140 25 + + CC cord-259669-fod4xkd7 140 26 , , , cord-259669-fod4xkd7 140 27 MHC MHC NNP cord-259669-fod4xkd7 140 28 - - HYPH cord-259669-fod4xkd7 140 29 class class NNP cord-259669-fod4xkd7 140 30 - - HYPH cord-259669-fod4xkd7 140 31 II ii CD cord-259669-fod4xkd7 140 32 positive positive JJ cord-259669-fod4xkd7 140 33 cells cell NNS cord-259669-fod4xkd7 140 34 . . . cord-259669-fod4xkd7 141 1 Subsequently subsequently RB cord-259669-fod4xkd7 141 2 , , , cord-259669-fod4xkd7 141 3 they -PRON- PRP cord-259669-fod4xkd7 141 4 went go VBD cord-259669-fod4xkd7 141 5 on on RP cord-259669-fod4xkd7 141 6 to to TO cord-259669-fod4xkd7 141 7 describe describe VB cord-259669-fod4xkd7 141 8 their -PRON- PRP$ cord-259669-fod4xkd7 141 9 ontogeny ontogeny NN cord-259669-fod4xkd7 141 10 [ [ -LRB- cord-259669-fod4xkd7 141 11 52 52 CD cord-259669-fod4xkd7 141 12 , , , cord-259669-fod4xkd7 141 13 53 53 CD cord-259669-fod4xkd7 141 14 ] ] -RRB- cord-259669-fod4xkd7 141 15 and and CC cord-259669-fod4xkd7 141 16 migration migration NN cord-259669-fod4xkd7 141 17 into into IN cord-259669-fod4xkd7 141 18 lymphoid lymphoid JJ cord-259669-fod4xkd7 141 19 tissue tissue NN cord-259669-fod4xkd7 141 20 after after IN cord-259669-fod4xkd7 141 21 viral viral JJ cord-259669-fod4xkd7 141 22 challenge challenge NN cord-259669-fod4xkd7 141 23 in in IN cord-259669-fod4xkd7 141 24 vivo vivo NNP cord-259669-fod4xkd7 141 25 [ [ -LRB- cord-259669-fod4xkd7 141 26 54 54 CD cord-259669-fod4xkd7 141 27 , , , cord-259669-fod4xkd7 141 28 55 55 CD cord-259669-fod4xkd7 141 29 ] ] -RRB- cord-259669-fod4xkd7 141 30 . . . cord-259669-fod4xkd7 142 1 Recently recently RB cord-259669-fod4xkd7 142 2 , , , cord-259669-fod4xkd7 142 3 using use VBG cord-259669-fod4xkd7 142 4 the the DT cord-259669-fod4xkd7 142 5 ovine ovine JJ cord-259669-fod4xkd7 142 6 and and CC cord-259669-fod4xkd7 142 7 porcine porcine JJ cord-259669-fod4xkd7 142 8 models model NNS cord-259669-fod4xkd7 142 9 , , , cord-259669-fod4xkd7 142 10 it -PRON- PRP cord-259669-fod4xkd7 142 11 has have VBZ cord-259669-fod4xkd7 142 12 been be VBN cord-259669-fod4xkd7 142 13 demonstrated demonstrate VBN cord-259669-fod4xkd7 142 14 that that IN cord-259669-fod4xkd7 142 15 pDC pdc CD cord-259669-fod4xkd7 142 16 also also RB cord-259669-fod4xkd7 142 17 migrate migrate VBP cord-259669-fod4xkd7 142 18 in in IN cord-259669-fod4xkd7 142 19 the the DT cord-259669-fod4xkd7 142 20 afferent afferent JJ cord-259669-fod4xkd7 142 21 lymph lymph NN cord-259669-fod4xkd7 142 22 of of IN cord-259669-fod4xkd7 142 23 cannulated cannulate VBN cord-259669-fod4xkd7 142 24 animals animal NNS cord-259669-fod4xkd7 142 25 [ [ -LRB- cord-259669-fod4xkd7 142 26 56 56 CD cord-259669-fod4xkd7 142 27 ] ] -RRB- cord-259669-fod4xkd7 142 28 . . . cord-259669-fod4xkd7 143 1 Phenotypically phenotypically RB cord-259669-fod4xkd7 143 2 , , , cord-259669-fod4xkd7 143 3 porcine porcine JJ cord-259669-fod4xkd7 143 4 pDC pDC NNP cord-259669-fod4xkd7 143 5 can can MD cord-259669-fod4xkd7 143 6 be be VB cord-259669-fod4xkd7 143 7 clearly clearly RB cord-259669-fod4xkd7 143 8 identified identify VBN cord-259669-fod4xkd7 143 9 as as IN cord-259669-fod4xkd7 143 10 CD172a CD172a NNP cord-259669-fod4xkd7 143 11 low low JJ cord-259669-fod4xkd7 143 12 CD4 CD4 NNP cord-259669-fod4xkd7 143 13 high high JJ cord-259669-fod4xkd7 143 14 CD14 CD14 NNP cord-259669-fod4xkd7 143 15 À à NN cord-259669-fod4xkd7 143 16 CD163 cd163 NN cord-259669-fod4xkd7 143 17 À à NN cord-259669-fod4xkd7 143 18 within within IN cord-259669-fod4xkd7 143 19 the the DT cord-259669-fod4xkd7 143 20 peripheral peripheral JJ cord-259669-fod4xkd7 143 21 blood blood NN cord-259669-fod4xkd7 143 22 population population NN cord-259669-fod4xkd7 143 23 ( ( -LRB- cord-259669-fod4xkd7 143 24 Table table NN cord-259669-fod4xkd7 143 25 1 1 CD cord-259669-fod4xkd7 143 26 ) ) -RRB- cord-259669-fod4xkd7 143 27 . . . cord-259669-fod4xkd7 144 1 They -PRON- PRP cord-259669-fod4xkd7 144 2 express express VBP cord-259669-fod4xkd7 144 3 no no DT cord-259669-fod4xkd7 144 4 or or CC cord-259669-fod4xkd7 144 5 low low JJ cord-259669-fod4xkd7 144 6 levels level NNS cord-259669-fod4xkd7 144 7 of of IN cord-259669-fod4xkd7 144 8 the the DT cord-259669-fod4xkd7 144 9 T t NN cord-259669-fod4xkd7 144 10 - - HYPH cord-259669-fod4xkd7 144 11 cell cell NN cord-259669-fod4xkd7 144 12 markers marker NNS cord-259669-fod4xkd7 144 13 CD3 CD3 NNP cord-259669-fod4xkd7 144 14 , , , cord-259669-fod4xkd7 144 15 CD5 CD5 NNP cord-259669-fod4xkd7 144 16 and and CC cord-259669-fod4xkd7 144 17 CD6 CD6 NNP cord-259669-fod4xkd7 144 18 , , , cord-259669-fod4xkd7 144 19 as as RB cord-259669-fod4xkd7 144 20 well well RB cord-259669-fod4xkd7 144 21 as as IN cord-259669-fod4xkd7 144 22 no no DT cord-259669-fod4xkd7 144 23 CD21 CD21 NNP cord-259669-fod4xkd7 144 24 [ [ -LRB- cord-259669-fod4xkd7 144 25 40 40 CD cord-259669-fod4xkd7 144 26 ] ] -RRB- cord-259669-fod4xkd7 144 27 , , , cord-259669-fod4xkd7 144 28 but but CC cord-259669-fod4xkd7 144 29 can can MD cord-259669-fod4xkd7 144 30 carry carry VB cord-259669-fod4xkd7 144 31 low low JJ cord-259669-fod4xkd7 144 32 levels level NNS cord-259669-fod4xkd7 144 33 of of IN cord-259669-fod4xkd7 144 34 CD1 cd1 NN cord-259669-fod4xkd7 144 35 and and CC cord-259669-fod4xkd7 144 36 moderate moderate JJ cord-259669-fod4xkd7 144 37 levels level NNS cord-259669-fod4xkd7 144 38 of of IN cord-259669-fod4xkd7 144 39 CD2 CD2 NNP cord-259669-fod4xkd7 144 40 ( ( -LRB- cord-259669-fod4xkd7 144 41 Fig Fig NNP cord-259669-fod4xkd7 144 42 . . . cord-259669-fod4xkd7 144 43 1 1 CD cord-259669-fod4xkd7 144 44 ) ) -RRB- cord-259669-fod4xkd7 144 45 . . . cord-259669-fod4xkd7 145 1 Related relate VBN cord-259669-fod4xkd7 145 2 to to IN cord-259669-fod4xkd7 145 3 their -PRON- PRP$ cord-259669-fod4xkd7 145 4 interaction interaction NN cord-259669-fod4xkd7 145 5 with with IN cord-259669-fod4xkd7 145 6 immune immune JJ cord-259669-fod4xkd7 145 7 complexes complex NNS cord-259669-fod4xkd7 146 1 porcine porcine NNP cord-259669-fod4xkd7 146 2 pDC pDC NNP cord-259669-fod4xkd7 146 3 express express JJ cord-259669-fod4xkd7 146 4 Fc Fc NNP cord-259669-fod4xkd7 146 5 receptors receptor NNS cord-259669-fod4xkd7 146 6 including include VBG cord-259669-fod4xkd7 146 7 CD16 CD16 NNP cord-259669-fod4xkd7 146 8 ( ( -LRB- cord-259669-fod4xkd7 146 9 Fig Fig NNP cord-259669-fod4xkd7 146 10 . . NNP cord-259669-fod4xkd7 146 11 1 1 CD cord-259669-fod4xkd7 146 12 , , , cord-259669-fod4xkd7 146 13 [ [ -LRB- cord-259669-fod4xkd7 146 14 40 40 CD cord-259669-fod4xkd7 146 15 ] ] -RRB- cord-259669-fod4xkd7 146 16 ) ) -RRB- cord-259669-fod4xkd7 146 17 and and CC cord-259669-fod4xkd7 146 18 CD32 CD32 NNP cord-259669-fod4xkd7 146 19 [ [ -LRB- cord-259669-fod4xkd7 146 20 57 57 CD cord-259669-fod4xkd7 146 21 ] ] -RRB- cord-259669-fod4xkd7 146 22 . . . cord-259669-fod4xkd7 147 1 In in IN cord-259669-fod4xkd7 147 2 contrast contrast NN cord-259669-fod4xkd7 147 3 to to IN cord-259669-fod4xkd7 147 4 porcine porcine NNP cord-259669-fod4xkd7 147 5 pDC pDC NNP cord-259669-fod4xkd7 147 6 , , , cord-259669-fod4xkd7 147 7 ovine ovine NNP cord-259669-fod4xkd7 147 8 pDC pDC NNP cord-259669-fod4xkd7 147 9 do do VBP cord-259669-fod4xkd7 147 10 not not RB cord-259669-fod4xkd7 147 11 express express VB cord-259669-fod4xkd7 147 12 CD4 CD4 NNP cord-259669-fod4xkd7 147 13 and and CC cord-259669-fod4xkd7 147 14 CD172a CD172a NNP cord-259669-fod4xkd7 147 15 but but CC cord-259669-fod4xkd7 147 16 are be VBP cord-259669-fod4xkd7 147 17 characterized characterize VBN cord-259669-fod4xkd7 147 18 by by IN cord-259669-fod4xkd7 147 19 high high JJ cord-259669-fod4xkd7 147 20 expression expression NN cord-259669-fod4xkd7 147 21 of of IN cord-259669-fod4xkd7 147 22 CD45RB CD45RB NNP cord-259669-fod4xkd7 147 23 [ [ -LRB- cord-259669-fod4xkd7 147 24 56 56 CD cord-259669-fod4xkd7 147 25 ] ] -RRB- cord-259669-fod4xkd7 147 26 . . . cord-259669-fod4xkd7 148 1 Porcine Porcine NNP cord-259669-fod4xkd7 148 2 pDC pDC NNP cord-259669-fod4xkd7 148 3 appear appear VBP cord-259669-fod4xkd7 148 4 to to TO cord-259669-fod4xkd7 148 5 be be VB cord-259669-fod4xkd7 148 6 the the DT cord-259669-fod4xkd7 148 7 major major JJ cord-259669-fod4xkd7 148 8 DC DC NNP cord-259669-fod4xkd7 148 9 population population NN cord-259669-fod4xkd7 148 10 producing produce VBG cord-259669-fod4xkd7 148 11 high high JJ cord-259669-fod4xkd7 148 12 quantities quantity NNS cord-259669-fod4xkd7 148 13 of of IN cord-259669-fod4xkd7 148 14 IFN IFN NNP cord-259669-fod4xkd7 148 15 - - : cord-259669-fod4xkd7 148 16 a a NN cord-259669-fod4xkd7 148 17 and and CC cord-259669-fod4xkd7 149 1 TNF- TNF- NNP cord-259669-fod4xkd7 149 2 ( ( -LRB- cord-259669-fod4xkd7 149 3 in in IN cord-259669-fod4xkd7 149 4 response response NN cord-259669-fod4xkd7 149 5 to to IN cord-259669-fod4xkd7 149 6 CpG CpG NNP cord-259669-fod4xkd7 149 7 motifs motifs NNP cord-259669-fod4xkd7 149 8 [ [ -LRB- cord-259669-fod4xkd7 149 9 58 58 CD cord-259669-fod4xkd7 149 10 ] ] -RRB- cord-259669-fod4xkd7 149 11 . . . cord-259669-fod4xkd7 150 1 This this DT cord-259669-fod4xkd7 150 2 clearly clearly RB cord-259669-fod4xkd7 150 3 relates relate VBZ cord-259669-fod4xkd7 150 4 to to IN cord-259669-fod4xkd7 150 5 the the DT cord-259669-fod4xkd7 150 6 human human JJ cord-259669-fod4xkd7 150 7 DC DC NNP cord-259669-fod4xkd7 150 8 system system NN cord-259669-fod4xkd7 150 9 , , , cord-259669-fod4xkd7 150 10 placing place VBG cord-259669-fod4xkd7 150 11 the the DT cord-259669-fod4xkd7 150 12 porcine porcine JJ cord-259669-fod4xkd7 150 13 DC DC NNP cord-259669-fod4xkd7 150 14 system system NN cord-259669-fod4xkd7 150 15 in in IN cord-259669-fod4xkd7 150 16 line line NN cord-259669-fod4xkd7 150 17 with with IN cord-259669-fod4xkd7 150 18 that that DT cord-259669-fod4xkd7 150 19 of of IN cord-259669-fod4xkd7 150 20 humans human NNS cord-259669-fod4xkd7 150 21 and and CC cord-259669-fod4xkd7 150 22 therefore therefore RB cord-259669-fod4xkd7 150 23 distinct distinct JJ cord-259669-fod4xkd7 150 24 from from IN cord-259669-fod4xkd7 150 25 the the DT cord-259669-fod4xkd7 150 26 murine murine JJ cord-259669-fod4xkd7 150 27 model model NN cord-259669-fod4xkd7 150 28 [ [ -LRB- cord-259669-fod4xkd7 150 29 59 59 CD cord-259669-fod4xkd7 150 30 ] ] -RRB- cord-259669-fod4xkd7 150 31 . . . cord-259669-fod4xkd7 151 1 Certainly certainly RB cord-259669-fod4xkd7 151 2 related related JJ cord-259669-fod4xkd7 151 3 to to IN cord-259669-fod4xkd7 151 4 their -PRON- PRP$ cord-259669-fod4xkd7 151 5 human human JJ cord-259669-fod4xkd7 151 6 and and CC cord-259669-fod4xkd7 151 7 mouse mouse NN cord-259669-fod4xkd7 151 8 counterparts counterpart NNS cord-259669-fod4xkd7 151 9 is be VBZ cord-259669-fod4xkd7 151 10 their -PRON- PRP$ cord-259669-fod4xkd7 151 11 ability ability NN cord-259669-fod4xkd7 151 12 to to TO cord-259669-fod4xkd7 151 13 respond respond VB cord-259669-fod4xkd7 151 14 to to IN cord-259669-fod4xkd7 151 15 many many JJ cord-259669-fod4xkd7 151 16 viruses virus NNS cord-259669-fod4xkd7 151 17 by by IN cord-259669-fod4xkd7 151 18 the the DT cord-259669-fod4xkd7 151 19 production production NN cord-259669-fod4xkd7 151 20 of of IN cord-259669-fod4xkd7 151 21 large large JJ cord-259669-fod4xkd7 151 22 quantities quantity NNS cord-259669-fod4xkd7 151 23 of of IN cord-259669-fod4xkd7 151 24 IFN IFN NNP cord-259669-fod4xkd7 151 25 - - : cord-259669-fod4xkd7 151 26 a a NNP cord-259669-fod4xkd7 151 27 ( ( -LRB- cord-259669-fod4xkd7 151 28 see see VB cord-259669-fod4xkd7 151 29 below below RB cord-259669-fod4xkd7 151 30 ) ) -RRB- cord-259669-fod4xkd7 151 31 . . . cord-259669-fod4xkd7 152 1 With with IN cord-259669-fod4xkd7 152 2 the the DT cord-259669-fod4xkd7 152 3 major major JJ cord-259669-fod4xkd7 152 4 site site NN cord-259669-fod4xkd7 152 5 for for IN cord-259669-fod4xkd7 152 6 pathogen pathogen NN cord-259669-fod4xkd7 152 7 entry entry NN cord-259669-fod4xkd7 152 8 being be VBG cord-259669-fod4xkd7 152 9 through through IN cord-259669-fod4xkd7 152 10 the the DT cord-259669-fod4xkd7 152 11 mucosa mucosa NN cord-259669-fod4xkd7 152 12 of of IN cord-259669-fod4xkd7 152 13 the the DT cord-259669-fod4xkd7 152 14 respiratory respiratory JJ cord-259669-fod4xkd7 152 15 and and CC cord-259669-fod4xkd7 152 16 digestive digestive JJ cord-259669-fod4xkd7 152 17 tract tract NN cord-259669-fod4xkd7 152 18 , , , cord-259669-fod4xkd7 152 19 it -PRON- PRP cord-259669-fod4xkd7 152 20 is be VBZ cord-259669-fod4xkd7 152 21 not not RB cord-259669-fod4xkd7 152 22 surprising surprising JJ cord-259669-fod4xkd7 152 23 that that IN cord-259669-fod4xkd7 152 24 most most JJS cord-259669-fod4xkd7 152 25 lymphocytes lymphocyte NNS cord-259669-fod4xkd7 152 26 are be VBP cord-259669-fod4xkd7 152 27 in in IN cord-259669-fod4xkd7 152 28 the the DT cord-259669-fod4xkd7 152 29 mucosalassociated mucosalassociated JJ cord-259669-fod4xkd7 152 30 lymphoid lymphoid JJ cord-259669-fod4xkd7 152 31 tissues tissue NNS cord-259669-fod4xkd7 152 32 ( ( -LRB- cord-259669-fod4xkd7 152 33 MALT MALT NNP cord-259669-fod4xkd7 152 34 ) ) -RRB- cord-259669-fod4xkd7 152 35 . . . cord-259669-fod4xkd7 153 1 Consequently consequently RB cord-259669-fod4xkd7 153 2 , , , cord-259669-fod4xkd7 153 3 it -PRON- PRP cord-259669-fod4xkd7 153 4 is be VBZ cord-259669-fod4xkd7 153 5 essential essential JJ cord-259669-fod4xkd7 153 6 to to TO cord-259669-fod4xkd7 153 7 regulate regulate VB cord-259669-fod4xkd7 153 8 the the DT cord-259669-fod4xkd7 153 9 mucosal mucosal JJ cord-259669-fod4xkd7 153 10 immune immune JJ cord-259669-fod4xkd7 153 11 responses response NNS cord-259669-fod4xkd7 153 12 against against IN cord-259669-fod4xkd7 153 13 harmless harmless JJ cord-259669-fod4xkd7 153 14 microorganisms microorganism NNS cord-259669-fod4xkd7 153 15 and and CC cord-259669-fod4xkd7 153 16 food food NN cord-259669-fod4xkd7 153 17 antigens antigen NNS cord-259669-fod4xkd7 153 18 in in IN cord-259669-fod4xkd7 153 19 contact contact NN cord-259669-fod4xkd7 153 20 with with IN cord-259669-fod4xkd7 153 21 the the DT cord-259669-fod4xkd7 153 22 mucosae mucosae NNP cord-259669-fod4xkd7 153 23 . . . cord-259669-fod4xkd7 154 1 This this DT cord-259669-fod4xkd7 154 2 is be VBZ cord-259669-fod4xkd7 154 3 a a DT cord-259669-fod4xkd7 154 4 major major JJ cord-259669-fod4xkd7 154 5 role role NN cord-259669-fod4xkd7 154 6 played play VBN cord-259669-fod4xkd7 154 7 by by IN cord-259669-fod4xkd7 154 8 mucosal mucosal JJ cord-259669-fod4xkd7 154 9 DC DC NNP cord-259669-fod4xkd7 154 10 and and CC cord-259669-fod4xkd7 154 11 is be VBZ cord-259669-fod4xkd7 154 12 reflected reflect VBN cord-259669-fod4xkd7 154 13 by by IN cord-259669-fod4xkd7 154 14 their -PRON- PRP$ cord-259669-fod4xkd7 154 15 anatomical anatomical JJ cord-259669-fod4xkd7 154 16 localization localization NN cord-259669-fod4xkd7 154 17 in in IN cord-259669-fod4xkd7 154 18 the the DT cord-259669-fod4xkd7 154 19 mucosal mucosal JJ cord-259669-fod4xkd7 154 20 tissues tissue NNS cord-259669-fod4xkd7 154 21 . . . cord-259669-fod4xkd7 155 1 They -PRON- PRP cord-259669-fod4xkd7 155 2 can can MD cord-259669-fod4xkd7 155 3 mediate mediate VB cord-259669-fod4xkd7 155 4 tolerance tolerance NN cord-259669-fod4xkd7 155 5 to to IN cord-259669-fod4xkd7 155 6 self self NN cord-259669-fod4xkd7 155 7 - - HYPH cord-259669-fod4xkd7 155 8 antigens antigen NNS cord-259669-fod4xkd7 155 9 and and CC cord-259669-fod4xkd7 155 10 harmless harmless JJ cord-259669-fod4xkd7 155 11 entities entity NNS cord-259669-fod4xkd7 155 12 , , , cord-259669-fod4xkd7 155 13 while while IN cord-259669-fod4xkd7 155 14 acting act VBG cord-259669-fod4xkd7 155 15 as as IN cord-259669-fod4xkd7 155 16 sentinels sentinel NNS cord-259669-fod4xkd7 155 17 sensing sense VBG cord-259669-fod4xkd7 155 18 the the DT cord-259669-fod4xkd7 155 19 danger danger NN cord-259669-fod4xkd7 155 20 posed pose VBN cord-259669-fod4xkd7 155 21 by by IN cord-259669-fod4xkd7 155 22 invading invade VBG cord-259669-fod4xkd7 155 23 pathogens pathogen NNS cord-259669-fod4xkd7 155 24 and and CC cord-259669-fod4xkd7 155 25 deleterious deleterious JJ cord-259669-fod4xkd7 155 26 entities entity NNS cord-259669-fod4xkd7 155 27 . . . cord-259669-fod4xkd7 156 1 The the DT cord-259669-fod4xkd7 156 2 first first JJ cord-259669-fod4xkd7 156 3 report report NN cord-259669-fod4xkd7 156 4 on on IN cord-259669-fod4xkd7 156 5 porcine porcine JJ cord-259669-fod4xkd7 156 6 mucosal mucosal NN cord-259669-fod4xkd7 156 7 DC DC NNP cord-259669-fod4xkd7 156 8 described describe VBD cord-259669-fod4xkd7 156 9 a a DT cord-259669-fod4xkd7 156 10 putative putative JJ cord-259669-fod4xkd7 156 11 DC DC NNP cord-259669-fod4xkd7 156 12 in in IN cord-259669-fod4xkd7 156 13 Peyer Peyer NNP cord-259669-fod4xkd7 156 14 's 's POS cord-259669-fod4xkd7 156 15 patches patch NNS cord-259669-fod4xkd7 156 16 ( ( -LRB- cord-259669-fod4xkd7 156 17 PP PP NNP cord-259669-fod4xkd7 156 18 ) ) -RRB- cord-259669-fod4xkd7 156 19 as as IN cord-259669-fod4xkd7 156 20 MHCII MHCII NNP cord-259669-fod4xkd7 156 21 + + CC cord-259669-fod4xkd7 156 22 cell cell NN cord-259669-fod4xkd7 157 1 lacking lack VBG cord-259669-fod4xkd7 157 2 T T NNP cord-259669-fod4xkd7 157 3 - - HYPH cord-259669-fod4xkd7 157 4 and and CC cord-259669-fod4xkd7 157 5 Bcell Bcell NNP cord-259669-fod4xkd7 157 6 markers marker NNS cord-259669-fod4xkd7 157 7 [ [ -LRB- cord-259669-fod4xkd7 157 8 60 60 CD cord-259669-fod4xkd7 157 9 ] ] -RRB- cord-259669-fod4xkd7 157 10 . . . cord-259669-fod4xkd7 158 1 In in IN cord-259669-fod4xkd7 158 2 the the DT cord-259669-fod4xkd7 158 3 lamina lamina JJ cord-259669-fod4xkd7 158 4 propria propria FW cord-259669-fod4xkd7 158 5 ( ( -LRB- cord-259669-fod4xkd7 158 6 LP LP NNP cord-259669-fod4xkd7 158 7 ) ) -RRB- cord-259669-fod4xkd7 158 8 of of IN cord-259669-fod4xkd7 158 9 the the DT cord-259669-fod4xkd7 158 10 small small JJ cord-259669-fod4xkd7 158 11 intestine intestine NN cord-259669-fod4xkd7 158 12 the the DT cord-259669-fod4xkd7 158 13 presence presence NN cord-259669-fod4xkd7 158 14 of of IN cord-259669-fod4xkd7 158 15 an an DT cord-259669-fod4xkd7 158 16 MHCII+CD172a MHCII+CD172a NNP cord-259669-fod4xkd7 159 1 + + CC cord-259669-fod4xkd7 160 1 CD11R1 CD11R1 NNP cord-259669-fod4xkd7 161 1 + + CC cord-259669-fod4xkd7 162 1 CD16 CD16 NNP cord-259669-fod4xkd7 162 2 + + CC cord-259669-fod4xkd7 162 3 DC DC NNP cord-259669-fod4xkd7 162 4 subset subset NNP cord-259669-fod4xkd7 162 5 was be VBD cord-259669-fod4xkd7 162 6 demonstrated demonstrate VBN cord-259669-fod4xkd7 162 7 [ [ -LRB- cord-259669-fod4xkd7 162 8 46 46 CD cord-259669-fod4xkd7 162 9 ] ] -RRB- cord-259669-fod4xkd7 162 10 . . . cord-259669-fod4xkd7 163 1 Bimczok Bimczok NNP cord-259669-fod4xkd7 163 2 and and CC cord-259669-fod4xkd7 163 3 colleagues colleague NNS cord-259669-fod4xkd7 163 4 [ [ -LRB- cord-259669-fod4xkd7 163 5 47 47 CD cord-259669-fod4xkd7 163 6 ] ] -RRB- cord-259669-fod4xkd7 163 7 further further JJ cord-259669-fod4xkd7 163 8 char char NN cord-259669-fod4xkd7 163 9 - - HYPH cord-259669-fod4xkd7 163 10 acterized acterize VBN cord-259669-fod4xkd7 163 11 DC DC NNP cord-259669-fod4xkd7 163 12 in in IN cord-259669-fod4xkd7 163 13 other other JJ cord-259669-fod4xkd7 163 14 immunological immunological JJ cord-259669-fod4xkd7 163 15 sites site NNS cord-259669-fod4xkd7 163 16 of of IN cord-259669-fod4xkd7 163 17 the the DT cord-259669-fod4xkd7 163 18 gut gut NN cord-259669-fod4xkd7 163 19 and and CC cord-259669-fod4xkd7 163 20 proposed propose VBD cord-259669-fod4xkd7 163 21 four four CD cord-259669-fod4xkd7 163 22 phenotypically phenotypically RB cord-259669-fod4xkd7 163 23 distinct distinct JJ cord-259669-fod4xkd7 163 24 subsets subset NNS cord-259669-fod4xkd7 163 25 of of IN cord-259669-fod4xkd7 163 26 DC DC NNP cord-259669-fod4xkd7 163 27 based base VBN cord-259669-fod4xkd7 163 28 on on IN cord-259669-fod4xkd7 163 29 the the DT cord-259669-fod4xkd7 163 30 expression expression NN cord-259669-fod4xkd7 163 31 of of IN cord-259669-fod4xkd7 163 32 CD11R1 CD11R1 NNP cord-259669-fod4xkd7 163 33 and and CC cord-259669-fod4xkd7 163 34 CD172a CD172a NNP cord-259669-fod4xkd7 163 35 . . . cord-259669-fod4xkd7 164 1 LP LP NNP cord-259669-fod4xkd7 164 2 DC DC NNP cord-259669-fod4xkd7 164 3 are be VBP cord-259669-fod4xkd7 164 4 mainly mainly RB cord-259669-fod4xkd7 164 5 CD172a cd172a NN cord-259669-fod4xkd7 165 1 + + CC cord-259669-fod4xkd7 166 1 CD11R1 CD11R1 NNP cord-259669-fod4xkd7 167 1 + + UH cord-259669-fod4xkd7 167 2 , , , cord-259669-fod4xkd7 167 3 PP PP NNP cord-259669-fod4xkd7 167 4 DC DC NNP cord-259669-fod4xkd7 167 5 are be VBP cord-259669-fod4xkd7 167 6 mainly mainly RB cord-259669-fod4xkd7 167 7 CD172a cd172a NN cord-259669-fod4xkd7 168 1 + + CC cord-259669-fod4xkd7 169 1 CD11R1 CD11R1 NNP cord-259669-fod4xkd7 169 2 À à NN cord-259669-fod4xkd7 169 3 in in IN cord-259669-fod4xkd7 169 4 subepithelial subepithelial JJ cord-259669-fod4xkd7 169 5 domes dome NNS cord-259669-fod4xkd7 169 6 and and CC cord-259669-fod4xkd7 169 7 CD172a CD172a NNP cord-259669-fod4xkd7 169 8 À à NN cord-259669-fod4xkd7 169 9 CD11R1 cd11r1 NN cord-259669-fod4xkd7 169 10 À à NN cord-259669-fod4xkd7 169 11 in in IN cord-259669-fod4xkd7 169 12 interfollicular interfollicular JJ cord-259669-fod4xkd7 169 13 regions region NNS cord-259669-fod4xkd7 169 14 , , , cord-259669-fod4xkd7 169 15 and and CC cord-259669-fod4xkd7 169 16 mesenteric mesenteric JJ cord-259669-fod4xkd7 169 17 lymph lymph NN cord-259669-fod4xkd7 169 18 node node NN cord-259669-fod4xkd7 169 19 ( ( -LRB- cord-259669-fod4xkd7 169 20 MLN MLN NNP cord-259669-fod4xkd7 169 21 ) ) -RRB- cord-259669-fod4xkd7 169 22 DC DC NNP cord-259669-fod4xkd7 169 23 are be VBP cord-259669-fod4xkd7 169 24 mostly mostly RB cord-259669-fod4xkd7 169 25 CD172a CD172a NNP cord-259669-fod4xkd7 169 26 À à NN cord-259669-fod4xkd7 169 27 CD11R1 cd11r1 NN cord-259669-fod4xkd7 170 1 + + UH cord-259669-fod4xkd7 170 2 . . . cord-259669-fod4xkd7 171 1 Interestingly interestingly RB cord-259669-fod4xkd7 171 2 , , , cord-259669-fod4xkd7 171 3 only only RB cord-259669-fod4xkd7 171 4 the the DT cord-259669-fod4xkd7 171 5 CD11R1 CD11R1 NNP cord-259669-fod4xkd7 171 6 + + CC cord-259669-fod4xkd7 171 7 DC DC NNP cord-259669-fod4xkd7 171 8 subsets subset NNS cord-259669-fod4xkd7 171 9 were be VBD cord-259669-fod4xkd7 171 10 present present JJ cord-259669-fod4xkd7 171 11 in in IN cord-259669-fod4xkd7 171 12 lymph lymph NN cord-259669-fod4xkd7 171 13 , , , cord-259669-fod4xkd7 171 14 suggesting suggest VBG cord-259669-fod4xkd7 171 15 that that IN cord-259669-fod4xkd7 171 16 DC DC NNP cord-259669-fod4xkd7 171 17 migration migration NN cord-259669-fod4xkd7 171 18 to to IN cord-259669-fod4xkd7 171 19 MLN mln NN cord-259669-fod4xkd7 171 20 originates originate VBZ cord-259669-fod4xkd7 171 21 largely largely RB cord-259669-fod4xkd7 171 22 from from IN cord-259669-fod4xkd7 171 23 the the DT cord-259669-fod4xkd7 171 24 LP LP NNP cord-259669-fod4xkd7 171 25 . . . cord-259669-fod4xkd7 172 1 With with IN cord-259669-fod4xkd7 172 2 respect respect NN cord-259669-fod4xkd7 172 3 to to IN cord-259669-fod4xkd7 172 4 antigen antigen NN cord-259669-fod4xkd7 172 5 sampling sampling NN cord-259669-fod4xkd7 172 6 a a DT cord-259669-fod4xkd7 172 7 rare rare JJ cord-259669-fod4xkd7 172 8 population population NN cord-259669-fod4xkd7 172 9 of of IN cord-259669-fod4xkd7 172 10 LP LP NNP cord-259669-fod4xkd7 172 11 DC DC NNP cord-259669-fod4xkd7 172 12 extending extend VBG cord-259669-fod4xkd7 172 13 cytoplasmic cytoplasmic JJ cord-259669-fod4xkd7 172 14 processes process NNS cord-259669-fod4xkd7 172 15 between between IN cord-259669-fod4xkd7 172 16 enterocytes enterocyte NNS cord-259669-fod4xkd7 172 17 have have VBP cord-259669-fod4xkd7 172 18 been be VBN cord-259669-fod4xkd7 172 19 described describe VBN cord-259669-fod4xkd7 172 20 [ [ -LRB- cord-259669-fod4xkd7 172 21 61 61 CD cord-259669-fod4xkd7 172 22 ] ] -RRB- cord-259669-fod4xkd7 172 23 . . . cord-259669-fod4xkd7 173 1 In in IN cord-259669-fod4xkd7 173 2 the the DT cord-259669-fod4xkd7 173 3 PP PP NNP cord-259669-fod4xkd7 173 4 , , , cord-259669-fod4xkd7 173 5 it -PRON- PRP cord-259669-fod4xkd7 173 6 appears appear VBZ cord-259669-fod4xkd7 173 7 that that IN cord-259669-fod4xkd7 173 8 antigen antigen NN cord-259669-fod4xkd7 173 9 transfer transfer NN cord-259669-fod4xkd7 173 10 from from IN cord-259669-fod4xkd7 173 11 M M NNP cord-259669-fod4xkd7 173 12 cells cell NNS cord-259669-fod4xkd7 173 13 to to IN cord-259669-fod4xkd7 173 14 DC DC NNP cord-259669-fod4xkd7 173 15 is be VBZ cord-259669-fod4xkd7 173 16 an an DT cord-259669-fod4xkd7 173 17 important important JJ cord-259669-fod4xkd7 173 18 process process NN cord-259669-fod4xkd7 173 19 , , , cord-259669-fod4xkd7 173 20 as as IN cord-259669-fod4xkd7 173 21 many many JJ cord-259669-fod4xkd7 173 22 DC DC NNP cord-259669-fod4xkd7 173 23 in in IN cord-259669-fod4xkd7 173 24 the the DT cord-259669-fod4xkd7 173 25 subepithelial subepithelial JJ cord-259669-fod4xkd7 173 26 dome dome NN cord-259669-fod4xkd7 173 27 have have VBP cord-259669-fod4xkd7 173 28 been be VBN cord-259669-fod4xkd7 173 29 demonstrated demonstrate VBN cord-259669-fod4xkd7 173 30 to to TO cord-259669-fod4xkd7 173 31 be be VB cord-259669-fod4xkd7 173 32 adjacent adjacent JJ cord-259669-fod4xkd7 173 33 to to IN cord-259669-fod4xkd7 173 34 M M NNP cord-259669-fod4xkd7 173 35 cells cell NNS cord-259669-fod4xkd7 173 36 [ [ -LRB- cord-259669-fod4xkd7 173 37 61 61 CD cord-259669-fod4xkd7 173 38 ] ] -RRB- cord-259669-fod4xkd7 173 39 . . . cord-259669-fod4xkd7 174 1 In in IN cord-259669-fod4xkd7 174 2 contrast contrast NN cord-259669-fod4xkd7 174 3 to to IN cord-259669-fod4xkd7 174 4 the the DT cord-259669-fod4xkd7 174 5 lack lack NN cord-259669-fod4xkd7 174 6 of of IN cord-259669-fod4xkd7 174 7 CD172a CD172a NNP cord-259669-fod4xkd7 174 8 on on IN cord-259669-fod4xkd7 174 9 many many JJ cord-259669-fod4xkd7 174 10 DC DC NNP cord-259669-fod4xkd7 174 11 in in IN cord-259669-fod4xkd7 174 12 the the DT cord-259669-fod4xkd7 174 13 inductive inductive JJ cord-259669-fod4xkd7 174 14 interfollicular interfollicular JJ cord-259669-fod4xkd7 174 15 areas area NNS cord-259669-fod4xkd7 174 16 of of IN cord-259669-fod4xkd7 174 17 the the DT cord-259669-fod4xkd7 174 18 MLN MLN NNP cord-259669-fod4xkd7 174 19 and and CC cord-259669-fod4xkd7 174 20 PP PP NNP cord-259669-fod4xkd7 174 21 , , , cord-259669-fod4xkd7 174 22 CD172a CD172a NNP cord-259669-fod4xkd7 174 23 is be VBZ cord-259669-fod4xkd7 174 24 expressed express VBN cord-259669-fod4xkd7 174 25 on on IN cord-259669-fod4xkd7 174 26 porcine porcine JJ cord-259669-fod4xkd7 174 27 DC DC NNP cord-259669-fod4xkd7 174 28 is be VBZ cord-259669-fod4xkd7 174 29 at at IN cord-259669-fod4xkd7 174 30 peripheral peripheral JJ cord-259669-fod4xkd7 174 31 sites site NNS cord-259669-fod4xkd7 174 32 of of IN cord-259669-fod4xkd7 174 33 pathogen pathogen NN cord-259669-fod4xkd7 174 34 entry entry NN cord-259669-fod4xkd7 174 35 and and CC cord-259669-fod4xkd7 174 36 antigen antigen NN cord-259669-fod4xkd7 174 37 contact contact NN cord-259669-fod4xkd7 174 38 such such JJ cord-259669-fod4xkd7 174 39 as as IN cord-259669-fod4xkd7 174 40 the the DT cord-259669-fod4xkd7 174 41 skin skin NN cord-259669-fod4xkd7 174 42 , , , cord-259669-fod4xkd7 174 43 LP LP NNP cord-259669-fod4xkd7 174 44 and and CC cord-259669-fod4xkd7 174 45 PP PP NNP cord-259669-fod4xkd7 174 46 subepithelial subepithelial JJ cord-259669-fod4xkd7 174 47 dome dome NN cord-259669-fod4xkd7 174 48 [ [ -LRB- cord-259669-fod4xkd7 174 49 46 46 CD cord-259669-fod4xkd7 174 50 , , , cord-259669-fod4xkd7 174 51 47 47 CD cord-259669-fod4xkd7 174 52 , , , cord-259669-fod4xkd7 174 53 62 62 CD cord-259669-fod4xkd7 174 54 ] ] -RRB- cord-259669-fod4xkd7 174 55 . . . cord-259669-fod4xkd7 175 1 This this DT cord-259669-fod4xkd7 175 2 would would MD cord-259669-fod4xkd7 175 3 indicate indicate VB cord-259669-fod4xkd7 175 4 a a DT cord-259669-fod4xkd7 175 5 possible possible JJ cord-259669-fod4xkd7 175 6 down down NN cord-259669-fod4xkd7 175 7 - - HYPH cord-259669-fod4xkd7 175 8 regulation regulation NN cord-259669-fod4xkd7 175 9 of of IN cord-259669-fod4xkd7 175 10 this this DT cord-259669-fod4xkd7 175 11 molecule molecule NN cord-259669-fod4xkd7 175 12 during during IN cord-259669-fod4xkd7 175 13 the the DT cord-259669-fod4xkd7 175 14 maturation maturation NN cord-259669-fod4xkd7 175 15 and and CC cord-259669-fod4xkd7 175 16 migration migration NN cord-259669-fod4xkd7 175 17 process process NN cord-259669-fod4xkd7 175 18 , , , cord-259669-fod4xkd7 175 19 and and CC cord-259669-fod4xkd7 175 20 would would MD cord-259669-fod4xkd7 175 21 be be VB cord-259669-fod4xkd7 175 22 supported support VBN cord-259669-fod4xkd7 175 23 by by IN cord-259669-fod4xkd7 175 24 the the DT cord-259669-fod4xkd7 175 25 observed observed JJ cord-259669-fod4xkd7 175 26 expression expression NN cord-259669-fod4xkd7 175 27 of of IN cord-259669-fod4xkd7 175 28 CD172a CD172a NNP cord-259669-fod4xkd7 175 29 on on IN cord-259669-fod4xkd7 175 30 MoDC MoDC NNP cord-259669-fod4xkd7 175 31 , , , cord-259669-fod4xkd7 175 32 BMDC BMDC NNP cord-259669-fod4xkd7 175 33 generated generate VBD cord-259669-fod4xkd7 175 34 using use VBG cord-259669-fod4xkd7 175 35 either either CC cord-259669-fod4xkd7 175 36 GM GM NNP cord-259669-fod4xkd7 175 37 - - HYPH cord-259669-fod4xkd7 175 38 CSF CSF NNP cord-259669-fod4xkd7 175 39 or or CC cord-259669-fod4xkd7 175 40 Flt3L flt3l NN cord-259669-fod4xkd7 175 41 , , , cord-259669-fod4xkd7 175 42 as as RB cord-259669-fod4xkd7 175 43 well well RB cord-259669-fod4xkd7 175 44 as as IN cord-259669-fod4xkd7 175 45 circulating circulate VBG cord-259669-fod4xkd7 175 46 blood blood NN cord-259669-fod4xkd7 175 47 CD172a cd172a NN cord-259669-fod4xkd7 175 48 + + CC cord-259669-fod4xkd7 176 1 blood blood NN cord-259669-fod4xkd7 176 2 APC APC NNP cord-259669-fod4xkd7 176 3 can can MD cord-259669-fod4xkd7 176 4 be be VB cord-259669-fod4xkd7 176 5 differentiated differentiate VBN cord-259669-fod4xkd7 176 6 into into IN cord-259669-fod4xkd7 176 7 CD14 CD14 NNP cord-259669-fod4xkd7 176 8 + + SYM cord-259669-fod4xkd7 176 9 monocytic monocytic JJ cord-259669-fod4xkd7 176 10 cells cell NNS cord-259669-fod4xkd7 176 11 and and CC cord-259669-fod4xkd7 176 12 CD14 CD14 NNP cord-259669-fod4xkd7 176 13 À À NNP cord-259669-fod4xkd7 176 14 DC DC NNP cord-259669-fod4xkd7 176 15 . . . cord-259669-fod4xkd7 177 1 Two two CD cord-259669-fod4xkd7 177 2 major major JJ cord-259669-fod4xkd7 177 3 subpopulations subpopulation NNS cord-259669-fod4xkd7 177 4 of of IN cord-259669-fod4xkd7 177 5 CD4 CD4 NNP cord-259669-fod4xkd7 177 6 À à IN cord-259669-fod4xkd7 177 7 monocytic monocytic JJ cord-259669-fod4xkd7 177 8 cells cell NNS cord-259669-fod4xkd7 177 9 can can MD cord-259669-fod4xkd7 177 10 be be VB cord-259669-fod4xkd7 177 11 defined define VBN cord-259669-fod4xkd7 177 12 based base VBN cord-259669-fod4xkd7 177 13 on on IN cord-259669-fod4xkd7 177 14 CD163 CD163 NNP cord-259669-fod4xkd7 177 15 expression expression NN cord-259669-fod4xkd7 177 16 ( ( -LRB- cord-259669-fod4xkd7 177 17 depicted depict VBN cord-259669-fod4xkd7 177 18 light light JJ cord-259669-fod4xkd7 177 19 blue blue JJ cord-259669-fod4xkd7 177 20 ; ; : cord-259669-fod4xkd7 177 21 see see VB cord-259669-fod4xkd7 177 22 also also RB cord-259669-fod4xkd7 177 23 Dominguez Dominguez NNP cord-259669-fod4xkd7 177 24 et et NNP cord-259669-fod4xkd7 177 25 al al NNP cord-259669-fod4xkd7 177 26 . . NNP cord-259669-fod4xkd7 177 27 , , , cord-259669-fod4xkd7 177 28 this this DT cord-259669-fod4xkd7 177 29 issue issue NN cord-259669-fod4xkd7 177 30 ) ) -RRB- cord-259669-fod4xkd7 177 31 . . . cord-259669-fod4xkd7 178 1 Furthermore furthermore RB cord-259669-fod4xkd7 178 2 , , , cord-259669-fod4xkd7 178 3 a a DT cord-259669-fod4xkd7 178 4 small small JJ cord-259669-fod4xkd7 178 5 CD4 CD4 NNP cord-259669-fod4xkd7 178 6 + + CC cord-259669-fod4xkd7 178 7 CD14 CD14 NNP cord-259669-fod4xkd7 178 8 + + CC cord-259669-fod4xkd7 178 9 CD163 CD163 NNP cord-259669-fod4xkd7 178 10 + + CC cord-259669-fod4xkd7 178 11 subset subset VBN cord-259669-fod4xkd7 178 12 with with IN cord-259669-fod4xkd7 178 13 unknown unknown JJ cord-259669-fod4xkd7 178 14 function function NN cord-259669-fod4xkd7 178 15 can can MD cord-259669-fod4xkd7 178 16 be be VB cord-259669-fod4xkd7 178 17 identified identify VBN cord-259669-fod4xkd7 178 18 ( ( -LRB- cord-259669-fod4xkd7 178 19 dark dark JJ cord-259669-fod4xkd7 178 20 blue blue JJ cord-259669-fod4xkd7 178 21 ) ) -RRB- cord-259669-fod4xkd7 178 22 . . . cord-259669-fod4xkd7 179 1 Porcine porcine JJ cord-259669-fod4xkd7 179 2 blood blood NN cord-259669-fod4xkd7 179 3 DC DC NNP cord-259669-fod4xkd7 179 4 express express VBP cord-259669-fod4xkd7 179 5 relatively relatively RB cord-259669-fod4xkd7 179 6 low low JJ cord-259669-fod4xkd7 179 7 levels level NNS cord-259669-fod4xkd7 179 8 of of IN cord-259669-fod4xkd7 179 9 CD172a cd172a NN cord-259669-fod4xkd7 179 10 and and CC cord-259669-fod4xkd7 179 11 lack lack JJ cord-259669-fod4xkd7 179 12 CD14 CD14 NNP cord-259669-fod4xkd7 179 13 and and CC cord-259669-fod4xkd7 179 14 CD163 CD163 NNP cord-259669-fod4xkd7 179 15 . . . cord-259669-fod4xkd7 180 1 While while IN cord-259669-fod4xkd7 180 2 cDC cDC NNS cord-259669-fod4xkd7 180 3 are be VBP cord-259669-fod4xkd7 180 4 CD4 CD4 NNP cord-259669-fod4xkd7 180 5 À À NNP cord-259669-fod4xkd7 180 6 ( ( -LRB- cord-259669-fod4xkd7 180 7 green green JJ cord-259669-fod4xkd7 180 8 ) ) -RRB- cord-259669-fod4xkd7 180 9 , , . cord-259669-fod4xkd7 181 1 pDC pDC NNP cord-259669-fod4xkd7 181 2 express express VB cord-259669-fod4xkd7 181 3 high high JJ cord-259669-fod4xkd7 181 4 levels level NNS cord-259669-fod4xkd7 181 5 of of IN cord-259669-fod4xkd7 181 6 CD4 CD4 NNP cord-259669-fod4xkd7 181 7 ( ( -LRB- cord-259669-fod4xkd7 181 8 red red NNP cord-259669-fod4xkd7 181 9 ) ) -RRB- cord-259669-fod4xkd7 181 10 . . . cord-259669-fod4xkd7 182 1 ( ( -LRB- cord-259669-fod4xkd7 182 2 B b NN cord-259669-fod4xkd7 182 3 ) ) -RRB- cord-259669-fod4xkd7 182 4 Expression expression NN cord-259669-fod4xkd7 182 5 of of IN cord-259669-fod4xkd7 182 6 CD14 CD14 NNP cord-259669-fod4xkd7 182 7 , , , cord-259669-fod4xkd7 182 8 MHC MHC NNP cord-259669-fod4xkd7 182 9 class class NN cord-259669-fod4xkd7 182 10 II II NNP cord-259669-fod4xkd7 182 11 , , , cord-259669-fod4xkd7 182 12 CD1 CD1 NNP cord-259669-fod4xkd7 182 13 , , , cord-259669-fod4xkd7 182 14 CD2 CD2 NNP cord-259669-fod4xkd7 182 15 , , , cord-259669-fod4xkd7 182 16 CD16 CD16 NNP cord-259669-fod4xkd7 182 17 and and CC cord-259669-fod4xkd7 182 18 CD163 CD163 NNP cord-259669-fod4xkd7 182 19 on on IN cord-259669-fod4xkd7 182 20 CD172a CD172a NNP cord-259669-fod4xkd7 182 21 high high JJ cord-259669-fod4xkd7 182 22 CD4 CD4 NNP cord-259669-fod4xkd7 182 23 À à NN cord-259669-fod4xkd7 182 24 monocytes monocyte NNS cord-259669-fod4xkd7 182 25 ( ( -LRB- cord-259669-fod4xkd7 182 26 light light JJ cord-259669-fod4xkd7 182 27 blue blue JJ cord-259669-fod4xkd7 182 28 dots dot NNS cord-259669-fod4xkd7 182 29 ) ) -RRB- cord-259669-fod4xkd7 182 30 , , . cord-259669-fod4xkd7 183 1 CD172a cd172a NN cord-259669-fod4xkd7 183 2 high high JJ cord-259669-fod4xkd7 183 3 CD4 CD4 NNP cord-259669-fod4xkd7 183 4 + + CC cord-259669-fod4xkd7 183 5 monocytic monocytic JJ cord-259669-fod4xkd7 183 6 cells cell NNS cord-259669-fod4xkd7 183 7 ( ( -LRB- cord-259669-fod4xkd7 183 8 dark dark JJ cord-259669-fod4xkd7 183 9 blue blue JJ cord-259669-fod4xkd7 183 10 dots dot NNS cord-259669-fod4xkd7 183 11 ) ) -RRB- cord-259669-fod4xkd7 183 12 , , . cord-259669-fod4xkd7 184 1 CD172a cd172a NN cord-259669-fod4xkd7 184 2 low low JJ cord-259669-fod4xkd7 185 1 CD4 CD4 NNP cord-259669-fod4xkd7 185 2 À À NNP cord-259669-fod4xkd7 185 3 cDC cDC NNP cord-259669-fod4xkd7 185 4 ( ( -LRB- cord-259669-fod4xkd7 185 5 green green JJ cord-259669-fod4xkd7 185 6 dots dot NNS cord-259669-fod4xkd7 185 7 ) ) -RRB- cord-259669-fod4xkd7 185 8 and and CC cord-259669-fod4xkd7 185 9 CD172a CD172a NNP cord-259669-fod4xkd7 185 10 low low JJ cord-259669-fod4xkd7 185 11 CD4 CD4 NNP cord-259669-fod4xkd7 185 12 + + CC cord-259669-fod4xkd7 186 1 pDC pDC NNP cord-259669-fod4xkd7 186 2 ( ( -LRB- cord-259669-fod4xkd7 186 3 red red JJ cord-259669-fod4xkd7 186 4 dots dot NNS cord-259669-fod4xkd7 186 5 ) ) -RRB- cord-259669-fod4xkd7 186 6 . . . cord-259669-fod4xkd7 187 1 A a DT cord-259669-fod4xkd7 187 2 representative representative JJ cord-259669-fod4xkd7 187 3 animal animal NN cord-259669-fod4xkd7 187 4 is be VBZ cord-259669-fod4xkd7 187 5 shown show VBN cord-259669-fod4xkd7 187 6 . . . cord-259669-fod4xkd7 188 1 Comparison comparison NN cord-259669-fod4xkd7 188 2 of of IN cord-259669-fod4xkd7 188 3 five five CD cord-259669-fod4xkd7 188 4 different different JJ cord-259669-fod4xkd7 188 5 SPF SPF NNP cord-259669-fod4xkd7 188 6 pigs pig NNS cord-259669-fod4xkd7 188 7 of of IN cord-259669-fod4xkd7 188 8 the the DT cord-259669-fod4xkd7 188 9 similar similar JJ cord-259669-fod4xkd7 188 10 age age NN cord-259669-fod4xkd7 188 11 ( ( -LRB- cord-259669-fod4xkd7 188 12 6 6 CD cord-259669-fod4xkd7 188 13 - - SYM cord-259669-fod4xkd7 188 14 12 12 CD cord-259669-fod4xkd7 188 15 month month NN cord-259669-fod4xkd7 188 16 old old JJ cord-259669-fod4xkd7 188 17 ) ) -RRB- cord-259669-fod4xkd7 188 18 revealed reveal VBD cord-259669-fod4xkd7 188 19 high high JJ cord-259669-fod4xkd7 188 20 variability variability NN cord-259669-fod4xkd7 188 21 in in IN cord-259669-fod4xkd7 188 22 the the DT cord-259669-fod4xkd7 188 23 expression expression NN cord-259669-fod4xkd7 188 24 levels level NNS cord-259669-fod4xkd7 188 25 of of IN cord-259669-fod4xkd7 188 26 MHC MHC NNP cord-259669-fod4xkd7 188 27 class class NN cord-259669-fod4xkd7 188 28 II II NNP cord-259669-fod4xkd7 188 29 , , , cord-259669-fod4xkd7 188 30 CD1 CD1 NNP cord-259669-fod4xkd7 188 31 , , , cord-259669-fod4xkd7 188 32 CD2 CD2 NNP cord-259669-fod4xkd7 188 33 and and CC cord-259669-fod4xkd7 188 34 CD16 CD16 NNP cord-259669-fod4xkd7 188 35 on on IN cord-259669-fod4xkd7 188 36 the the DT cord-259669-fod4xkd7 188 37 DC DC NNP cord-259669-fod4xkd7 188 38 subpopulations subpopulation NNS cord-259669-fod4xkd7 188 39 . . . cord-259669-fod4xkd7 189 1 DC DC NNP cord-259669-fod4xkd7 189 2 [ [ -LRB- cord-259669-fod4xkd7 189 3 23 23 CD cord-259669-fod4xkd7 189 4 , , , cord-259669-fod4xkd7 189 5 37 37 CD cord-259669-fod4xkd7 189 6 , , , cord-259669-fod4xkd7 189 7 38 38 CD cord-259669-fod4xkd7 189 8 ] ] -RRB- cord-259669-fod4xkd7 189 9 . . . cord-259669-fod4xkd7 190 1 Nevertheless nevertheless RB cord-259669-fod4xkd7 190 2 , , , cord-259669-fod4xkd7 190 3 with with IN cord-259669-fod4xkd7 190 4 in in FW cord-259669-fod4xkd7 190 5 vitro vitro FW cord-259669-fod4xkd7 190 6 maturation maturation NN cord-259669-fod4xkd7 190 7 studies study NNS cord-259669-fod4xkd7 190 8 using use VBG cord-259669-fod4xkd7 190 9 MoDC MoDC NNP cord-259669-fod4xkd7 190 10 , , , cord-259669-fod4xkd7 190 11 BMDC BMDC NNP cord-259669-fod4xkd7 190 12 as as RB cord-259669-fod4xkd7 190 13 well well RB cord-259669-fod4xkd7 190 14 as as IN cord-259669-fod4xkd7 190 15 blood blood NN cord-259669-fod4xkd7 190 16 DC DC NNP cord-259669-fod4xkd7 190 17 [ [ -LRB- cord-259669-fod4xkd7 190 18 23 23 CD cord-259669-fod4xkd7 190 19 , , , cord-259669-fod4xkd7 190 20 57 57 CD cord-259669-fod4xkd7 190 21 , , , cord-259669-fod4xkd7 190 22 58 58 CD cord-259669-fod4xkd7 190 23 , , , cord-259669-fod4xkd7 190 24 63 63 CD cord-259669-fod4xkd7 190 25 , , , cord-259669-fod4xkd7 190 26 64 64 CD cord-259669-fod4xkd7 190 27 ] ] -RRB- cord-259669-fod4xkd7 191 1 no no DT cord-259669-fod4xkd7 191 2 loss loss NN cord-259669-fod4xkd7 191 3 of of IN cord-259669-fod4xkd7 191 4 CD172a CD172a NNP cord-259669-fod4xkd7 191 5 was be VBD cord-259669-fod4xkd7 191 6 observed observe VBN cord-259669-fod4xkd7 191 7 indicating indicate VBG cord-259669-fod4xkd7 191 8 that that IN cord-259669-fod4xkd7 191 9 additional additional JJ cord-259669-fod4xkd7 191 10 factors factor NNS cord-259669-fod4xkd7 191 11 would would MD cord-259669-fod4xkd7 191 12 be be VB cord-259669-fod4xkd7 191 13 required require VBN cord-259669-fod4xkd7 191 14 for for IN cord-259669-fod4xkd7 191 15 this this DT cord-259669-fod4xkd7 191 16 process process NN cord-259669-fod4xkd7 191 17 . . . cord-259669-fod4xkd7 192 1 An an DT cord-259669-fod4xkd7 192 2 alternative alternative JJ cord-259669-fod4xkd7 192 3 explanation explanation NN cord-259669-fod4xkd7 192 4 would would MD cord-259669-fod4xkd7 192 5 be be VB cord-259669-fod4xkd7 192 6 that that IN cord-259669-fod4xkd7 192 7 CD172a CD172a NNP cord-259669-fod4xkd7 192 8 À à NN cord-259669-fod4xkd7 192 9 DC DC NNP cord-259669-fod4xkd7 192 10 represent represent VBP cord-259669-fod4xkd7 192 11 lymph lymph NN cord-259669-fod4xkd7 192 12 node node NN cord-259669-fod4xkd7 192 13 tissue tissue NN cord-259669-fod4xkd7 192 14 resident resident NN cord-259669-fod4xkd7 192 15 DC DC NNP cord-259669-fod4xkd7 192 16 which which WDT cord-259669-fod4xkd7 192 17 are be VBP cord-259669-fod4xkd7 192 18 phenotypically phenotypically RB cord-259669-fod4xkd7 192 19 distinct distinct JJ cord-259669-fod4xkd7 192 20 from from IN cord-259669-fod4xkd7 192 21 in in IN cord-259669-fod4xkd7 192 22 vitro vitro FW cord-259669-fod4xkd7 192 23 generated generate VBD cord-259669-fod4xkd7 192 24 DC DC NNP cord-259669-fod4xkd7 192 25 . . . cord-259669-fod4xkd7 193 1 In in IN cord-259669-fod4xkd7 193 2 humans human NNS cord-259669-fod4xkd7 193 3 , , , cord-259669-fod4xkd7 193 4 rat rat NN cord-259669-fod4xkd7 193 5 , , , cord-259669-fod4xkd7 193 6 cattle cattle NNS cord-259669-fod4xkd7 193 7 and and CC cord-259669-fod4xkd7 193 8 sheep sheep NNS cord-259669-fod4xkd7 193 9 , , , cord-259669-fod4xkd7 193 10 the the DT cord-259669-fod4xkd7 193 11 expression expression NN cord-259669-fod4xkd7 193 12 of of IN cord-259669-fod4xkd7 193 13 CD172a CD172a NNP cord-259669-fod4xkd7 193 14 differentiates differentiate VBZ cord-259669-fod4xkd7 193 15 functionally functionally RB cord-259669-fod4xkd7 193 16 distinct distinct JJ cord-259669-fod4xkd7 193 17 DC DC NNP cord-259669-fod4xkd7 193 18 subsets subset NNS cord-259669-fod4xkd7 193 19 . . . cord-259669-fod4xkd7 194 1 While while IN cord-259669-fod4xkd7 194 2 CD172a CD172a NNP cord-259669-fod4xkd7 194 3 + + CC cord-259669-fod4xkd7 194 4 DC DC NNP cord-259669-fod4xkd7 194 5 are be VBP cord-259669-fod4xkd7 194 6 more more RBR cord-259669-fod4xkd7 194 7 stimulatory stimulatory JJ cord-259669-fod4xkd7 194 8 for for IN cord-259669-fod4xkd7 194 9 T t NN cord-259669-fod4xkd7 194 10 cells cell NNS cord-259669-fod4xkd7 194 11 , , , cord-259669-fod4xkd7 194 12 it -PRON- PRP cord-259669-fod4xkd7 194 13 is be VBZ cord-259669-fod4xkd7 194 14 possible possible JJ cord-259669-fod4xkd7 194 15 that that IN cord-259669-fod4xkd7 194 16 the the DT cord-259669-fod4xkd7 194 17 CD172a cd172a NN cord-259669-fod4xkd7 194 18 À à NN cord-259669-fod4xkd7 194 19 subsets subset NNS cord-259669-fod4xkd7 194 20 is be VBZ cord-259669-fod4xkd7 194 21 specialized specialize VBN cord-259669-fod4xkd7 194 22 in in IN cord-259669-fod4xkd7 194 23 the the DT cord-259669-fod4xkd7 194 24 phagocytosis phagocytosis NN cord-259669-fod4xkd7 194 25 of of IN cord-259669-fod4xkd7 194 26 apoptotic apoptotic JJ cord-259669-fod4xkd7 194 27 cells cell NNS cord-259669-fod4xkd7 194 28 [ [ -LRB- cord-259669-fod4xkd7 194 29 65 65 CD cord-259669-fod4xkd7 194 30 ] ] -RRB- cord-259669-fod4xkd7 195 1 [ [ -LRB- cord-259669-fod4xkd7 195 2 66 66 CD cord-259669-fod4xkd7 195 3 ] ] -RRB- cord-259669-fod4xkd7 196 1 [ [ -LRB- cord-259669-fod4xkd7 196 2 67 67 CD cord-259669-fod4xkd7 196 3 ] ] -RRB- cord-259669-fod4xkd7 197 1 [ [ -LRB- cord-259669-fod4xkd7 197 2 68 68 CD cord-259669-fod4xkd7 197 3 ] ] -RRB- cord-259669-fod4xkd7 197 4 [ [ -LRB- cord-259669-fod4xkd7 197 5 69 69 CD cord-259669-fod4xkd7 197 6 ] ] -RRB- cord-259669-fod4xkd7 197 7 . . . cord-259669-fod4xkd7 198 1 Future future JJ cord-259669-fod4xkd7 198 2 studies study NNS cord-259669-fod4xkd7 198 3 are be VBP cord-259669-fod4xkd7 198 4 required require VBN cord-259669-fod4xkd7 198 5 to to TO cord-259669-fod4xkd7 198 6 clarify clarify VB cord-259669-fod4xkd7 198 7 such such JJ cord-259669-fod4xkd7 198 8 functional functional JJ cord-259669-fod4xkd7 198 9 differences difference NNS cord-259669-fod4xkd7 198 10 in in IN cord-259669-fod4xkd7 198 11 the the DT cord-259669-fod4xkd7 198 12 pig pig NN cord-259669-fod4xkd7 198 13 . . . cord-259669-fod4xkd7 199 1 DCs dc NNS cord-259669-fod4xkd7 199 2 from from IN cord-259669-fod4xkd7 199 3 the the DT cord-259669-fod4xkd7 199 4 porcine porcine JJ cord-259669-fod4xkd7 199 5 upper upper JJ cord-259669-fod4xkd7 199 6 respiratory respiratory JJ cord-259669-fod4xkd7 199 7 tract tract NN cord-259669-fod4xkd7 199 8 have have VBP cord-259669-fod4xkd7 199 9 also also RB cord-259669-fod4xkd7 199 10 been be VBN cord-259669-fod4xkd7 199 11 described describe VBN cord-259669-fod4xkd7 199 12 . . . cord-259669-fod4xkd7 200 1 In in IN cord-259669-fod4xkd7 200 2 the the DT cord-259669-fod4xkd7 200 3 tracheal tracheal NN cord-259669-fod4xkd7 200 4 mucosa mucosa NN cord-259669-fod4xkd7 200 5 many many JJ cord-259669-fod4xkd7 200 6 DC DC NNP cord-259669-fod4xkd7 200 7 are be VBP cord-259669-fod4xkd7 200 8 located locate VBN cord-259669-fod4xkd7 200 9 above above IN cord-259669-fod4xkd7 200 10 the the DT cord-259669-fod4xkd7 200 11 basal basal NN cord-259669-fod4xkd7 200 12 membrane membrane NN cord-259669-fod4xkd7 200 13 and and CC cord-259669-fod4xkd7 200 14 inside inside IN cord-259669-fod4xkd7 200 15 the the DT cord-259669-fod4xkd7 200 16 epithelial epithelial JJ cord-259669-fod4xkd7 200 17 layer layer NN cord-259669-fod4xkd7 200 18 where where WRB cord-259669-fod4xkd7 200 19 they -PRON- PRP cord-259669-fod4xkd7 200 20 form form VBP cord-259669-fod4xkd7 200 21 a a DT cord-259669-fod4xkd7 200 22 dense dense JJ cord-259669-fod4xkd7 200 23 network network NN cord-259669-fod4xkd7 200 24 with with IN cord-259669-fod4xkd7 200 25 many many JJ cord-259669-fod4xkd7 200 26 cytoplasmic cytoplasmic JJ cord-259669-fod4xkd7 200 27 processes process NNS cord-259669-fod4xkd7 200 28 probably probably RB cord-259669-fod4xkd7 200 29 related relate VBN cord-259669-fod4xkd7 200 30 to to IN cord-259669-fod4xkd7 200 31 their -PRON- PRP$ cord-259669-fod4xkd7 200 32 important important JJ cord-259669-fod4xkd7 200 33 role role NN cord-259669-fod4xkd7 200 34 as as IN cord-259669-fod4xkd7 200 35 immunological immunological JJ cord-259669-fod4xkd7 200 36 sentinels sentinel NNS cord-259669-fod4xkd7 200 37 in in IN cord-259669-fod4xkd7 200 38 this this DT cord-259669-fod4xkd7 200 39 organ organ NN cord-259669-fod4xkd7 200 40 [ [ -LRB- cord-259669-fod4xkd7 200 41 61 61 CD cord-259669-fod4xkd7 200 42 ] ] -RRB- cord-259669-fod4xkd7 200 43 . . . cord-259669-fod4xkd7 201 1 The the DT cord-259669-fod4xkd7 201 2 majority majority NN cord-259669-fod4xkd7 201 3 of of IN cord-259669-fod4xkd7 201 4 these these DT cord-259669-fod4xkd7 201 5 cells cell NNS cord-259669-fod4xkd7 201 6 co co VBP cord-259669-fod4xkd7 201 7 - - VBD cord-259669-fod4xkd7 201 8 express express JJ cord-259669-fod4xkd7 201 9 CD16 CD16 NNP cord-259669-fod4xkd7 201 10 and and CC cord-259669-fod4xkd7 201 11 MHC MHC NNP cord-259669-fod4xkd7 201 12 class class NN cord-259669-fod4xkd7 201 13 II II NNP cord-259669-fod4xkd7 201 14 but but CC cord-259669-fod4xkd7 201 15 not not RB cord-259669-fod4xkd7 201 16 CD11R1 CD11R1 NNP cord-259669-fod4xkd7 201 17 . . . cord-259669-fod4xkd7 202 1 Jamin Jamin NNP cord-259669-fod4xkd7 202 2 et et NNP cord-259669-fod4xkd7 202 3 al al NNP cord-259669-fod4xkd7 202 4 . . . cord-259669-fod4xkd7 203 1 [ [ -LRB- cord-259669-fod4xkd7 203 2 49 49 CD cord-259669-fod4xkd7 203 3 ] ] -RRB- cord-259669-fod4xkd7 203 4 recently recently RB cord-259669-fod4xkd7 203 5 described describe VBD cord-259669-fod4xkd7 203 6 putative putative JJ cord-259669-fod4xkd7 203 7 DC DC NNP cord-259669-fod4xkd7 203 8 in in IN cord-259669-fod4xkd7 203 9 the the DT cord-259669-fod4xkd7 203 10 tonsils tonsil NNS cord-259669-fod4xkd7 203 11 by by IN cord-259669-fod4xkd7 203 12 co co NN cord-259669-fod4xkd7 203 13 - - NN cord-259669-fod4xkd7 203 14 expression expression NN cord-259669-fod4xkd7 203 15 of of IN cord-259669-fod4xkd7 203 16 CD11R1 cd11r1 NN cord-259669-fod4xkd7 203 17 and and CC cord-259669-fod4xkd7 203 18 CD208 CD208 NNP cord-259669-fod4xkd7 203 19 ( ( -LRB- cord-259669-fod4xkd7 203 20 DC DC NNP cord-259669-fod4xkd7 203 21 lamp lamp NN cord-259669-fod4xkd7 203 22 ) ) -RRB- cord-259669-fod4xkd7 203 23 or or CC cord-259669-fod4xkd7 203 24 coexpression coexpression NN cord-259669-fod4xkd7 203 25 of of IN cord-259669-fod4xkd7 203 26 CD11R1 CD11R1 NNP cord-259669-fod4xkd7 203 27 and and CC cord-259669-fod4xkd7 203 28 CD172a CD172a NNP cord-259669-fod4xkd7 203 29 . . . cord-259669-fod4xkd7 204 1 Nevertheless nevertheless RB cord-259669-fod4xkd7 204 2 , , , cord-259669-fod4xkd7 204 3 from from IN cord-259669-fod4xkd7 204 4 this this DT cord-259669-fod4xkd7 204 5 study study NN cord-259669-fod4xkd7 204 6 it -PRON- PRP cord-259669-fod4xkd7 204 7 is be VBZ cord-259669-fod4xkd7 204 8 unclear unclear JJ cord-259669-fod4xkd7 204 9 whether whether IN cord-259669-fod4xkd7 204 10 a a DT cord-259669-fod4xkd7 204 11 CD172a CD172a NNP cord-259669-fod4xkd7 204 12 À à NN cord-259669-fod4xkd7 204 13 DC DC NNP cord-259669-fod4xkd7 204 14 would would MD cord-259669-fod4xkd7 204 15 exist exist VB cord-259669-fod4xkd7 204 16 in in IN cord-259669-fod4xkd7 204 17 this this DT cord-259669-fod4xkd7 204 18 organ organ NN cord-259669-fod4xkd7 204 19 . . . cord-259669-fod4xkd7 205 1 It -PRON- PRP cord-259669-fod4xkd7 205 2 is be VBZ cord-259669-fod4xkd7 205 3 also also RB cord-259669-fod4xkd7 205 4 not not RB cord-259669-fod4xkd7 205 5 yet yet RB cord-259669-fod4xkd7 205 6 clear clear JJ cord-259669-fod4xkd7 205 7 how how WRB cord-259669-fod4xkd7 205 8 CD172a CD172a NNP cord-259669-fod4xkd7 205 9 is be VBZ cord-259669-fod4xkd7 205 10 expressed express VBN cord-259669-fod4xkd7 205 11 in in IN cord-259669-fod4xkd7 205 12 DC DC NNP cord-259669-fod4xkd7 205 13 of of IN cord-259669-fod4xkd7 205 14 non non JJ cord-259669-fod4xkd7 205 15 - - JJ cord-259669-fod4xkd7 205 16 mucosal mucosal JJ cord-259669-fod4xkd7 205 17 lymphoid lymphoid JJ cord-259669-fod4xkd7 205 18 tissue tissue NN cord-259669-fod4xkd7 205 19 . . . cord-259669-fod4xkd7 206 1 Several several JJ cord-259669-fod4xkd7 206 2 functional functional JJ cord-259669-fod4xkd7 206 3 properties property NNS cord-259669-fod4xkd7 206 4 have have VBP cord-259669-fod4xkd7 206 5 been be VBN cord-259669-fod4xkd7 206 6 assigned assign VBN cord-259669-fod4xkd7 206 7 to to TO cord-259669-fod4xkd7 206 8 mucosal mucosal VB cord-259669-fod4xkd7 206 9 DC DC NNP cord-259669-fod4xkd7 206 10 originating originate VBG cord-259669-fod4xkd7 206 11 from from IN cord-259669-fod4xkd7 206 12 the the DT cord-259669-fod4xkd7 206 13 gut gut NN cord-259669-fod4xkd7 206 14 including include VBG cord-259669-fod4xkd7 206 15 the the DT cord-259669-fod4xkd7 206 16 capacity capacity NN cord-259669-fod4xkd7 206 17 to to TO cord-259669-fod4xkd7 206 18 imprint imprint VB cord-259669-fod4xkd7 206 19 the the DT cord-259669-fod4xkd7 206 20 mucosal mucosal JJ cord-259669-fod4xkd7 206 21 homing homing NN cord-259669-fod4xkd7 206 22 receptors receptor NNS cord-259669-fod4xkd7 206 23 a4b7 a4b7 IN cord-259669-fod4xkd7 206 24 integrin integrin NN cord-259669-fod4xkd7 206 25 and and CC cord-259669-fod4xkd7 206 26 CCR9 CCR9 NNP cord-259669-fod4xkd7 206 27 on on IN cord-259669-fod4xkd7 206 28 T T NNP cord-259669-fod4xkd7 206 29 and and CC cord-259669-fod4xkd7 206 30 B b NN cord-259669-fod4xkd7 206 31 lymphocytes lymphocyte NNS cord-259669-fod4xkd7 206 32 , , , cord-259669-fod4xkd7 206 33 the the DT cord-259669-fod4xkd7 206 34 secretion secretion NN cord-259669-fod4xkd7 206 35 of of IN cord-259669-fod4xkd7 206 36 cytokines cytokine NNS cord-259669-fod4xkd7 206 37 of of IN cord-259669-fod4xkd7 206 38 the the DT cord-259669-fod4xkd7 206 39 mucosal mucosal JJ cord-259669-fod4xkd7 206 40 microenvironment microenvironment NN cord-259669-fod4xkd7 206 41 such such JJ cord-259669-fod4xkd7 206 42 as as IN cord-259669-fod4xkd7 206 43 IL-10 IL-10 NNP cord-259669-fod4xkd7 206 44 and and CC cord-259669-fod4xkd7 206 45 TGF TGF NNP cord-259669-fod4xkd7 206 46 - - HYPH cord-259669-fod4xkd7 206 47 b b NNP cord-259669-fod4xkd7 206 48 , , , cord-259669-fod4xkd7 206 49 the the DT cord-259669-fod4xkd7 206 50 promotion promotion NN cord-259669-fod4xkd7 206 51 of of IN cord-259669-fod4xkd7 206 52 T T NNP cord-259669-fod4xkd7 206 53 regulatory regulatory JJ cord-259669-fod4xkd7 206 54 and and CC cord-259669-fod4xkd7 206 55 Th2 th2 CD cord-259669-fod4xkd7 206 56 rather rather RB cord-259669-fod4xkd7 206 57 than than IN cord-259669-fod4xkd7 206 58 Th1 th1 NN cord-259669-fod4xkd7 206 59 responses response NNS cord-259669-fod4xkd7 206 60 , , , cord-259669-fod4xkd7 206 61 and and CC cord-259669-fod4xkd7 206 62 the the DT cord-259669-fod4xkd7 206 63 induction induction NN cord-259669-fod4xkd7 206 64 of of IN cord-259669-fod4xkd7 206 65 IgA IgA NNP cord-259669-fod4xkd7 206 66 secretion secretion NN cord-259669-fod4xkd7 206 67 [ [ -LRB- cord-259669-fod4xkd7 206 68 70 70 CD cord-259669-fod4xkd7 206 69 ] ] -RRB- cord-259669-fod4xkd7 206 70 [ [ -LRB- cord-259669-fod4xkd7 206 71 71 71 CD cord-259669-fod4xkd7 206 72 ] ] -RRB- cord-259669-fod4xkd7 206 73 [ [ -LRB- cord-259669-fod4xkd7 206 74 72 72 CD cord-259669-fod4xkd7 206 75 ] ] -RRB- cord-259669-fod4xkd7 206 76 [ [ -LRB- cord-259669-fod4xkd7 206 77 73 73 CD cord-259669-fod4xkd7 206 78 ] ] -RRB- cord-259669-fod4xkd7 206 79 [ [ -LRB- cord-259669-fod4xkd7 206 80 74 74 CD cord-259669-fod4xkd7 206 81 ] ] -RRB- cord-259669-fod4xkd7 206 82 . . . cord-259669-fod4xkd7 207 1 Considering consider VBG cord-259669-fod4xkd7 207 2 that that IN cord-259669-fod4xkd7 207 3 the the DT cord-259669-fod4xkd7 207 4 capacity capacity NN cord-259669-fod4xkd7 207 5 of of IN cord-259669-fod4xkd7 207 6 gut gut NN cord-259669-fod4xkd7 207 7 DC DC NNP cord-259669-fod4xkd7 207 8 to to TO cord-259669-fod4xkd7 207 9 produce produce VB cord-259669-fod4xkd7 207 10 retinoic retinoic JJ cord-259669-fod4xkd7 207 11 acid acid NN cord-259669-fod4xkd7 207 12 ( ( -LRB- cord-259669-fod4xkd7 207 13 RA RA NNP cord-259669-fod4xkd7 207 14 ) ) -RRB- cord-259669-fod4xkd7 207 15 is be VBZ cord-259669-fod4xkd7 207 16 a a DT cord-259669-fod4xkd7 207 17 requirement requirement NN cord-259669-fod4xkd7 207 18 for for IN cord-259669-fod4xkd7 207 19 many many JJ cord-259669-fod4xkd7 207 20 of of IN cord-259669-fod4xkd7 207 21 these these DT cord-259669-fod4xkd7 207 22 functions function NNS cord-259669-fod4xkd7 207 23 and and CC cord-259669-fod4xkd7 207 24 that that DT cord-259669-fod4xkd7 207 25 gut gut NN cord-259669-fod4xkd7 207 26 DC DC NNP cord-259669-fod4xkd7 207 27 are be VBP cord-259669-fod4xkd7 207 28 likely likely JJ cord-259669-fod4xkd7 207 29 to to TO cord-259669-fod4xkd7 207 30 be be VB cord-259669-fod4xkd7 207 31 themselves -PRON- PRP cord-259669-fod4xkd7 207 32 under under IN cord-259669-fod4xkd7 207 33 the the DT cord-259669-fod4xkd7 207 34 influence influence NN cord-259669-fod4xkd7 207 35 of of IN cord-259669-fod4xkd7 207 36 RA RA NNP cord-259669-fod4xkd7 207 37 derived derive VBN cord-259669-fod4xkd7 207 38 from from IN cord-259669-fod4xkd7 207 39 gut gut NN cord-259669-fod4xkd7 207 40 epithelial epithelial JJ cord-259669-fod4xkd7 207 41 cells cell NNS cord-259669-fod4xkd7 207 42 , , , cord-259669-fod4xkd7 207 43 we -PRON- PRP cord-259669-fod4xkd7 207 44 have have VBP cord-259669-fod4xkd7 207 45 tested test VBN cord-259669-fod4xkd7 207 46 whether whether IN cord-259669-fod4xkd7 207 47 porcine porcine JJ cord-259669-fod4xkd7 207 48 MoDC modc NN cord-259669-fod4xkd7 207 49 can can MD cord-259669-fod4xkd7 207 50 acquire acquire VB cord-259669-fod4xkd7 207 51 the the DT cord-259669-fod4xkd7 207 52 function function NN cord-259669-fod4xkd7 207 53 of of IN cord-259669-fod4xkd7 207 54 gut gut NN cord-259669-fod4xkd7 207 55 mucosal mucosal JJ cord-259669-fod4xkd7 207 56 DC DC NNP cord-259669-fod4xkd7 207 57 . . . cord-259669-fod4xkd7 208 1 After after IN cord-259669-fod4xkd7 208 2 treatment treatment NN cord-259669-fod4xkd7 208 3 of of IN cord-259669-fod4xkd7 208 4 porcine porcine JJ cord-259669-fod4xkd7 208 5 MoDC modc NN cord-259669-fod4xkd7 208 6 with with IN cord-259669-fod4xkd7 208 7 RA RA NNP cord-259669-fod4xkd7 208 8 the the DT cord-259669-fod4xkd7 208 9 DC DC NNP cord-259669-fod4xkd7 208 10 acquired acquire VBD cord-259669-fod4xkd7 208 11 the the DT cord-259669-fod4xkd7 208 12 capacity capacity NN cord-259669-fod4xkd7 208 13 to to TO cord-259669-fod4xkd7 208 14 promote promote VB cord-259669-fod4xkd7 208 15 a4b7 a4b7 JJ cord-259669-fod4xkd7 208 16 integrin integrin NN cord-259669-fod4xkd7 208 17 and and CC cord-259669-fod4xkd7 208 18 CCR9 CCR9 NNP cord-259669-fod4xkd7 208 19 on on IN cord-259669-fod4xkd7 208 20 T t NN cord-259669-fod4xkd7 208 21 lymphocytes lymphocyte NNS cord-259669-fod4xkd7 208 22 , , , cord-259669-fod4xkd7 208 23 to to TO cord-259669-fod4xkd7 208 24 secrete secrete VB cord-259669-fod4xkd7 208 25 TGF TGF NNP cord-259669-fod4xkd7 208 26 - - HYPH cord-259669-fod4xkd7 208 27 b b NN cord-259669-fod4xkd7 208 28 and and CC cord-259669-fod4xkd7 208 29 to to TO cord-259669-fod4xkd7 208 30 promote promote VB cord-259669-fod4xkd7 208 31 IgA IgA NNP cord-259669-fod4xkd7 208 32 responses response NNS cord-259669-fod4xkd7 208 33 [ [ -LRB- cord-259669-fod4xkd7 208 34 75 75 CD cord-259669-fod4xkd7 208 35 ] ] -RRB- cord-259669-fod4xkd7 208 36 . . . cord-259669-fod4xkd7 209 1 We -PRON- PRP cord-259669-fod4xkd7 209 2 have have VBP cord-259669-fod4xkd7 209 3 extended extend VBN cord-259669-fod4xkd7 209 4 these these DT cord-259669-fod4xkd7 209 5 studies study NNS cord-259669-fod4xkd7 209 6 and and CC cord-259669-fod4xkd7 209 7 also also RB cord-259669-fod4xkd7 209 8 demonstrated demonstrate VBD cord-259669-fod4xkd7 209 9 that that IN cord-259669-fod4xkd7 209 10 RA RA NNP cord-259669-fod4xkd7 209 11 induces induce VBZ cord-259669-fod4xkd7 209 12 the the DT cord-259669-fod4xkd7 209 13 expression expression NN cord-259669-fod4xkd7 209 14 of of IN cord-259669-fod4xkd7 209 15 retinaldehydrogenase retinaldehydrogenase NN cord-259669-fod4xkd7 209 16 , , , cord-259669-fod4xkd7 209 17 a a DT cord-259669-fod4xkd7 209 18 rate rate NN cord-259669-fod4xkd7 209 19 - - HYPH cord-259669-fod4xkd7 209 20 limiting limit VBG cord-259669-fod4xkd7 209 21 enzyme enzyme NN cord-259669-fod4xkd7 209 22 in in IN cord-259669-fod4xkd7 209 23 the the DT cord-259669-fod4xkd7 209 24 synthesis synthesis NN cord-259669-fod4xkd7 209 25 of of IN cord-259669-fod4xkd7 209 26 RA RA NNP cord-259669-fod4xkd7 209 27 . . . cord-259669-fod4xkd7 210 1 The the DT cord-259669-fod4xkd7 210 2 drug drug NN cord-259669-fod4xkd7 210 3 - - HYPH cord-259669-fod4xkd7 210 4 mediated mediate VBN cord-259669-fod4xkd7 210 5 inhibition inhibition NN cord-259669-fod4xkd7 210 6 of of IN cord-259669-fod4xkd7 210 7 this this DT cord-259669-fod4xkd7 210 8 enzyme enzyme NN cord-259669-fod4xkd7 210 9 in in IN cord-259669-fod4xkd7 210 10 RA RA NNP cord-259669-fod4xkd7 210 11 - - HYPH cord-259669-fod4xkd7 210 12 treated treat VBN cord-259669-fod4xkd7 210 13 DC DC NNP cord-259669-fod4xkd7 210 14 abrogated abrogate VBD cord-259669-fod4xkd7 210 15 their -PRON- PRP$ cord-259669-fod4xkd7 210 16 capacity capacity NN cord-259669-fod4xkd7 210 17 to to TO cord-259669-fod4xkd7 210 18 promote promote VB cord-259669-fod4xkd7 210 19 mucosal mucosal JJ cord-259669-fod4xkd7 210 20 homing homing JJ cord-259669-fod4xkd7 210 21 receptors receptor NNS cord-259669-fod4xkd7 210 22 expression expression NN cord-259669-fod4xkd7 210 23 on on IN cord-259669-fod4xkd7 210 24 lymphocytes lymphocyte NNS cord-259669-fod4xkd7 210 25 ( ( -LRB- cord-259669-fod4xkd7 210 26 Saurer Saurer NNP cord-259669-fod4xkd7 210 27 and and CC cord-259669-fod4xkd7 210 28 Summerfield Summerfield NNP cord-259669-fod4xkd7 210 29 , , , cord-259669-fod4xkd7 210 30 unpublished unpublished JJ cord-259669-fod4xkd7 210 31 data datum NNS cord-259669-fod4xkd7 210 32 ) ) -RRB- cord-259669-fod4xkd7 210 33 . . . cord-259669-fod4xkd7 211 1 This this DT cord-259669-fod4xkd7 211 2 underlines underline VBZ cord-259669-fod4xkd7 211 3 the the DT cord-259669-fod4xkd7 211 4 important important JJ cord-259669-fod4xkd7 211 5 role role NN cord-259669-fod4xkd7 211 6 of of IN cord-259669-fod4xkd7 211 7 tissue tissue NN cord-259669-fod4xkd7 211 8 - - HYPH cord-259669-fod4xkd7 211 9 specific specific JJ cord-259669-fod4xkd7 211 10 factors factor NNS cord-259669-fod4xkd7 211 11 in in IN cord-259669-fod4xkd7 211 12 governing govern VBG cord-259669-fod4xkd7 211 13 DC DC NNP cord-259669-fod4xkd7 211 14 function function NN cord-259669-fod4xkd7 211 15 . . . cord-259669-fod4xkd7 212 1 NIPC NIPC NNP cord-259669-fod4xkd7 212 2 / / SYM cord-259669-fod4xkd7 212 3 pDC pDC NNP cord-259669-fod4xkd7 212 4 have have VBP cord-259669-fod4xkd7 212 5 been be VBN cord-259669-fod4xkd7 212 6 identified identify VBN cord-259669-fod4xkd7 212 7 as as IN cord-259669-fod4xkd7 212 8 IFN IFN NNP cord-259669-fod4xkd7 212 9 - - HYPH cord-259669-fod4xkd7 212 10 a a DT cord-259669-fod4xkd7 212 11 - - HYPH cord-259669-fod4xkd7 212 12 positive positive JJ cord-259669-fod4xkd7 212 13 cells cell NNS cord-259669-fod4xkd7 212 14 by by IN cord-259669-fod4xkd7 212 15 immunohistochemistry immunohistochemistry NN cord-259669-fod4xkd7 212 16 in in IN cord-259669-fod4xkd7 212 17 the the DT cord-259669-fod4xkd7 212 18 intestinal intestinal JJ cord-259669-fod4xkd7 212 19 epithelial epithelial JJ cord-259669-fod4xkd7 212 20 layer layer NN cord-259669-fod4xkd7 212 21 , , , cord-259669-fod4xkd7 212 22 the the DT cord-259669-fod4xkd7 212 23 LP LP NNP cord-259669-fod4xkd7 212 24 , , , cord-259669-fod4xkd7 212 25 near near IN cord-259669-fod4xkd7 212 26 the the DT cord-259669-fod4xkd7 212 27 PP PP NNP cord-259669-fod4xkd7 212 28 and and CC cord-259669-fod4xkd7 212 29 in in IN cord-259669-fod4xkd7 212 30 the the DT cord-259669-fod4xkd7 212 31 MLN mln NN cord-259669-fod4xkd7 212 32 early early RB cord-259669-fod4xkd7 212 33 after after IN cord-259669-fod4xkd7 212 34 infection infection NN cord-259669-fod4xkd7 212 35 with with IN cord-259669-fod4xkd7 212 36 transmissible transmissible JJ cord-259669-fod4xkd7 212 37 gastroenteritis gastroenteritis NN cord-259669-fod4xkd7 212 38 virus virus NN cord-259669-fod4xkd7 212 39 ( ( -LRB- cord-259669-fod4xkd7 212 40 TGEV TGEV NNP cord-259669-fod4xkd7 212 41 ) ) -RRB- cord-259669-fod4xkd7 212 42 [ [ -LRB- cord-259669-fod4xkd7 212 43 55 55 CD cord-259669-fod4xkd7 212 44 ] ] -RRB- cord-259669-fod4xkd7 212 45 . . . cord-259669-fod4xkd7 213 1 Since since IN cord-259669-fod4xkd7 213 2 this this DT cord-259669-fod4xkd7 213 3 was be VBD cord-259669-fod4xkd7 213 4 associated associate VBN cord-259669-fod4xkd7 213 5 with with IN cord-259669-fod4xkd7 213 6 high high JJ cord-259669-fod4xkd7 213 7 levels level NNS cord-259669-fod4xkd7 213 8 of of IN cord-259669-fod4xkd7 213 9 serum serum NN cord-259669-fod4xkd7 213 10 IFN IFN NNP cord-259669-fod4xkd7 213 11 - - HYPH cord-259669-fod4xkd7 213 12 a a NNP cord-259669-fod4xkd7 213 13 and and CC cord-259669-fod4xkd7 213 14 only only RB cord-259669-fod4xkd7 213 15 few few JJ cord-259669-fod4xkd7 213 16 IFN IFN NNP cord-259669-fod4xkd7 213 17 - - : cord-259669-fod4xkd7 213 18 a a DT cord-259669-fod4xkd7 213 19 producing produce VBG cord-259669-fod4xkd7 213 20 cells cell NNS cord-259669-fod4xkd7 213 21 were be VBD cord-259669-fod4xkd7 213 22 identified identify VBN cord-259669-fod4xkd7 213 23 in in IN cord-259669-fod4xkd7 213 24 other other JJ cord-259669-fod4xkd7 213 25 organs organ NNS cord-259669-fod4xkd7 214 1 it -PRON- PRP cord-259669-fod4xkd7 214 2 appears appear VBZ cord-259669-fod4xkd7 214 3 that that IN cord-259669-fod4xkd7 214 4 during during IN cord-259669-fod4xkd7 214 5 an an DT cord-259669-fod4xkd7 214 6 enteropathic enteropathic JJ cord-259669-fod4xkd7 214 7 virus virus NN cord-259669-fod4xkd7 214 8 infection infection NN cord-259669-fod4xkd7 214 9 IFN IFN NNP cord-259669-fod4xkd7 214 10 - - : cord-259669-fod4xkd7 214 11 a a DT cord-259669-fod4xkd7 214 12 would would MD cord-259669-fod4xkd7 214 13 almost almost RB cord-259669-fod4xkd7 214 14 exclusively exclusively RB cord-259669-fod4xkd7 214 15 originate originate VB cord-259669-fod4xkd7 214 16 from from IN cord-259669-fod4xkd7 214 17 gut gut NN cord-259669-fod4xkd7 214 18 pDC pDC NNP cord-259669-fod4xkd7 214 19 triggered trigger VBN cord-259669-fod4xkd7 214 20 locally locally RB cord-259669-fod4xkd7 214 21 . . . cord-259669-fod4xkd7 215 1 The the DT cord-259669-fod4xkd7 215 2 rapid rapid JJ cord-259669-fod4xkd7 215 3 IFN IFN NNP cord-259669-fod4xkd7 215 4 - - : cord-259669-fod4xkd7 215 5 a a DT cord-259669-fod4xkd7 215 6 response response NN cord-259669-fod4xkd7 215 7 of of IN cord-259669-fod4xkd7 215 8 pDC pDC NNP cord-259669-fod4xkd7 215 9 as as RB cord-259669-fod4xkd7 215 10 early early RB cord-259669-fod4xkd7 215 11 as as IN cord-259669-fod4xkd7 215 12 6 6 CD cord-259669-fod4xkd7 215 13 h h NN cord-259669-fod4xkd7 215 14 after after IN cord-259669-fod4xkd7 215 15 infection infection NN cord-259669-fod4xkd7 215 16 would would MD cord-259669-fod4xkd7 215 17 imply imply VB cord-259669-fod4xkd7 215 18 that that IN cord-259669-fod4xkd7 215 19 pDC pDC NNP cord-259669-fod4xkd7 215 20 are be VBP cord-259669-fod4xkd7 215 21 present present JJ cord-259669-fod4xkd7 215 22 in in IN cord-259669-fod4xkd7 215 23 mucosal mucosal JJ cord-259669-fod4xkd7 215 24 tissue tissue NN cord-259669-fod4xkd7 215 25 fulfilling fulfil VBG cord-259669-fod4xkd7 215 26 their -PRON- PRP$ cord-259669-fod4xkd7 215 27 role role NN cord-259669-fod4xkd7 215 28 as as IN cord-259669-fod4xkd7 215 29 sentinels sentinel NNS cord-259669-fod4xkd7 215 30 . . . cord-259669-fod4xkd7 216 1 This this DT cord-259669-fod4xkd7 216 2 relates relate VBZ cord-259669-fod4xkd7 216 3 to to IN cord-259669-fod4xkd7 216 4 the the DT cord-259669-fod4xkd7 216 5 recently recently RB cord-259669-fod4xkd7 216 6 identified identify VBN cord-259669-fod4xkd7 216 7 CCR9 ccr9 JJ cord-259669-fod4xkd7 216 8 expression expression NN cord-259669-fod4xkd7 216 9 and and CC cord-259669-fod4xkd7 216 10 migration migration NN cord-259669-fod4xkd7 216 11 of of IN cord-259669-fod4xkd7 216 12 mouse mouse NN cord-259669-fod4xkd7 216 13 pDC pDC NNP cord-259669-fod4xkd7 216 14 to to IN cord-259669-fod4xkd7 216 15 the the DT cord-259669-fod4xkd7 216 16 small small JJ cord-259669-fod4xkd7 216 17 intestine intestine NN cord-259669-fod4xkd7 216 18 under under IN cord-259669-fod4xkd7 216 19 steady steady JJ cord-259669-fod4xkd7 216 20 - - HYPH cord-259669-fod4xkd7 216 21 state state NN cord-259669-fod4xkd7 216 22 conditions condition NNS cord-259669-fod4xkd7 216 23 [ [ -LRB- cord-259669-fod4xkd7 216 24 76 76 CD cord-259669-fod4xkd7 216 25 ] ] -RRB- cord-259669-fod4xkd7 216 26 and and CC cord-259669-fod4xkd7 216 27 also also RB cord-259669-fod4xkd7 216 28 to to IN cord-259669-fod4xkd7 216 29 the the DT cord-259669-fod4xkd7 216 30 presence presence NN cord-259669-fod4xkd7 216 31 of of IN cord-259669-fod4xkd7 216 32 pDC pDC NNP cord-259669-fod4xkd7 216 33 identified identify VBN cord-259669-fod4xkd7 216 34 as as IN cord-259669-fod4xkd7 216 35 CD172a CD172a NNP cord-259669-fod4xkd7 216 36 + + CC cord-259669-fod4xkd7 216 37 CD4 CD4 NNP cord-259669-fod4xkd7 216 38 + + CC cord-259669-fod4xkd7 216 39 cells cell NNS cord-259669-fod4xkd7 216 40 in in IN cord-259669-fod4xkd7 216 41 tonsils tonsil NNS cord-259669-fod4xkd7 216 42 and and CC cord-259669-fod4xkd7 216 43 MLN mln NN cord-259669-fod4xkd7 216 44 of of IN cord-259669-fod4xkd7 216 45 healthy healthy JJ cord-259669-fod4xkd7 216 46 pigs pig NNS cord-259669-fod4xkd7 216 47 [ [ -LRB- cord-259669-fod4xkd7 216 48 49 49 CD cord-259669-fod4xkd7 216 49 ] ] -RRB- cord-259669-fod4xkd7 216 50 . . . cord-259669-fod4xkd7 217 1 Bautista Bautista NNP cord-259669-fod4xkd7 217 2 et et NNP cord-259669-fod4xkd7 217 3 al al NNP cord-259669-fod4xkd7 217 4 . . NNP cord-259669-fod4xkd7 217 5 have have VBP cord-259669-fod4xkd7 217 6 isolated isolate VBN cord-259669-fod4xkd7 217 7 DC DC NNP cord-259669-fod4xkd7 217 8 migrating migrate VBG cord-259669-fod4xkd7 217 9 from from IN cord-259669-fod4xkd7 217 10 porcine porcine JJ cord-259669-fod4xkd7 217 11 skin skin NN cord-259669-fod4xkd7 217 12 explants explant NNS cord-259669-fod4xkd7 217 13 . . . cord-259669-fod4xkd7 218 1 Phentotypically phentotypically RB cord-259669-fod4xkd7 218 2 these these DT cord-259669-fod4xkd7 218 3 cells cell NNS cord-259669-fod4xkd7 218 4 resemble resemble VBP cord-259669-fod4xkd7 218 5 MoDC modc NN cord-259669-fod4xkd7 218 6 in in IN cord-259669-fod4xkd7 218 7 terms term NNS cord-259669-fod4xkd7 218 8 of of IN cord-259669-fod4xkd7 218 9 CD172a cd172a NN cord-259669-fod4xkd7 218 10 co co NN cord-259669-fod4xkd7 218 11 - - NN cord-259669-fod4xkd7 218 12 expression expression NN cord-259669-fod4xkd7 218 13 with with IN cord-259669-fod4xkd7 218 14 CD1 CD1 NNP cord-259669-fod4xkd7 218 15 and and CC cord-259669-fod4xkd7 218 16 the the DT cord-259669-fod4xkd7 218 17 high high JJ cord-259669-fod4xkd7 218 18 levels level NNS cord-259669-fod4xkd7 218 19 of of IN cord-259669-fod4xkd7 218 20 MHC MHC NNP cord-259669-fod4xkd7 218 21 class class NN cord-259669-fod4xkd7 218 22 II II NNP cord-259669-fod4xkd7 218 23 and and CC cord-259669-fod4xkd7 218 24 CD80/86 cd80/86 CD cord-259669-fod4xkd7 218 25 ( ( -LRB- cord-259669-fod4xkd7 218 26 Table table NN cord-259669-fod4xkd7 218 27 1 1 CD cord-259669-fod4xkd7 218 28 ) ) -RRB- cord-259669-fod4xkd7 218 29 . . . cord-259669-fod4xkd7 219 1 Moreover moreover RB cord-259669-fod4xkd7 219 2 , , , cord-259669-fod4xkd7 219 3 isolated isolate VBN cord-259669-fod4xkd7 219 4 skin skin NN cord-259669-fod4xkd7 219 5 - - HYPH cord-259669-fod4xkd7 219 6 derived derive VBN cord-259669-fod4xkd7 219 7 DC DC NNP cord-259669-fod4xkd7 219 8 show show VBP cord-259669-fod4xkd7 219 9 variable variable JJ cord-259669-fod4xkd7 219 10 expression expression NN cord-259669-fod4xkd7 219 11 of of IN cord-259669-fod4xkd7 219 12 CD11R2 cd11r2 NN cord-259669-fod4xkd7 219 13 , , , cord-259669-fod4xkd7 219 14 CD14 CD14 NNP cord-259669-fod4xkd7 219 15 and and CC cord-259669-fod4xkd7 219 16 CD16 CD16 NNP cord-259669-fod4xkd7 219 17 [ [ -LRB- cord-259669-fod4xkd7 219 18 62 62 CD cord-259669-fod4xkd7 219 19 ] ] -RRB- cord-259669-fod4xkd7 219 20 . . . cord-259669-fod4xkd7 220 1 Immunohistochemical immunohistochemical JJ cord-259669-fod4xkd7 220 2 analysis analysis NN cord-259669-fod4xkd7 220 3 of of IN cord-259669-fod4xkd7 220 4 porcine porcine JJ cord-259669-fod4xkd7 220 5 thymic thymic JJ cord-259669-fod4xkd7 220 6 tissue tissue NN cord-259669-fod4xkd7 220 7 has have VBZ cord-259669-fod4xkd7 220 8 shown show VBN cord-259669-fod4xkd7 220 9 DC DC NNP cord-259669-fod4xkd7 220 10 to to TO cord-259669-fod4xkd7 220 11 be be VB cord-259669-fod4xkd7 220 12 large large JJ cord-259669-fod4xkd7 220 13 cells cell NNS cord-259669-fod4xkd7 220 14 located locate VBN cord-259669-fod4xkd7 220 15 in in IN cord-259669-fod4xkd7 220 16 the the DT cord-259669-fod4xkd7 220 17 medullary medullary NN cord-259669-fod4xkd7 220 18 and and CC cord-259669-fod4xkd7 220 19 the the DT cord-259669-fod4xkd7 220 20 corticomedullary corticomedullary JJ cord-259669-fod4xkd7 220 21 regions region NNS cord-259669-fod4xkd7 220 22 , , , cord-259669-fod4xkd7 220 23 as as IN cord-259669-fod4xkd7 220 24 evidenced evidence VBN cord-259669-fod4xkd7 220 25 by by IN cord-259669-fod4xkd7 220 26 the the DT cord-259669-fod4xkd7 220 27 presence presence NN cord-259669-fod4xkd7 220 28 of of IN cord-259669-fod4xkd7 220 29 surrounding surround VBG cord-259669-fod4xkd7 220 30 Hassall Hassall NNP cord-259669-fod4xkd7 220 31 's 's POS cord-259669-fod4xkd7 220 32 corpuscles corpuscle NNS cord-259669-fod4xkd7 220 33 . . . cord-259669-fod4xkd7 221 1 Porcine porcine JJ cord-259669-fod4xkd7 221 2 thymic thymic JJ cord-259669-fod4xkd7 221 3 DC DC NNP cord-259669-fod4xkd7 221 4 have have VBP cord-259669-fod4xkd7 221 5 also also RB cord-259669-fod4xkd7 221 6 been be VBN cord-259669-fod4xkd7 221 7 partially partially RB cord-259669-fod4xkd7 221 8 purified purify VBN cord-259669-fod4xkd7 221 9 and and CC cord-259669-fod4xkd7 221 10 characterized characterize VBN cord-259669-fod4xkd7 221 11 [ [ -LRB- cord-259669-fod4xkd7 221 12 77 77 CD cord-259669-fod4xkd7 221 13 ] ] -RRB- cord-259669-fod4xkd7 221 14 . . . cord-259669-fod4xkd7 222 1 They -PRON- PRP cord-259669-fod4xkd7 222 2 too too RB cord-259669-fod4xkd7 222 3 relate relate VBP cord-259669-fod4xkd7 222 4 to to IN cord-259669-fod4xkd7 222 5 MoDC modc VB cord-259669-fod4xkd7 222 6 and and CC cord-259669-fod4xkd7 222 7 skin skin VB cord-259669-fod4xkd7 222 8 DC DC NNP cord-259669-fod4xkd7 222 9 in in IN cord-259669-fod4xkd7 222 10 their -PRON- PRP$ cord-259669-fod4xkd7 222 11 CD1 CD1 NNP cord-259669-fod4xkd7 222 12 , , , cord-259669-fod4xkd7 222 13 CD172a CD172a NNP cord-259669-fod4xkd7 222 14 and and CC cord-259669-fod4xkd7 222 15 MHC MHC NNP cord-259669-fod4xkd7 222 16 class class NN cord-259669-fod4xkd7 222 17 II ii CD cord-259669-fod4xkd7 222 18 expressions expression NNS cord-259669-fod4xkd7 222 19 , , , cord-259669-fod4xkd7 222 20 but but CC cord-259669-fod4xkd7 222 21 additionally additionally RB cord-259669-fod4xkd7 222 22 express express VBP cord-259669-fod4xkd7 222 23 CD2 CD2 NNP cord-259669-fod4xkd7 222 24 ( ( -LRB- cord-259669-fod4xkd7 222 25 Table Table NNP cord-259669-fod4xkd7 222 26 1 1 CD cord-259669-fod4xkd7 222 27 ) ) -RRB- cord-259669-fod4xkd7 222 28 , , , cord-259669-fod4xkd7 222 29 which which WDT cord-259669-fod4xkd7 222 30 can can MD cord-259669-fod4xkd7 222 31 also also RB cord-259669-fod4xkd7 222 32 be be VB cord-259669-fod4xkd7 222 33 found find VBN cord-259669-fod4xkd7 222 34 on on IN cord-259669-fod4xkd7 222 35 blood blood NN cord-259669-fod4xkd7 222 36 DC DC NNP cord-259669-fod4xkd7 222 37 ( ( -LRB- cord-259669-fod4xkd7 222 38 Fig Fig NNP cord-259669-fod4xkd7 222 39 . . . cord-259669-fod4xkd7 222 40 1 1 CD cord-259669-fod4xkd7 222 41 ) ) -RRB- cord-259669-fod4xkd7 222 42 . . . cord-259669-fod4xkd7 223 1 Croizet Croizet NNP cord-259669-fod4xkd7 223 2 and and CC cord-259669-fod4xkd7 223 3 colleagues colleague NNS cord-259669-fod4xkd7 223 4 [ [ -LRB- cord-259669-fod4xkd7 223 5 78 78 CD cord-259669-fod4xkd7 223 6 ] ] -RRB- cord-259669-fod4xkd7 223 7 demonstrated demonstrate VBD cord-259669-fod4xkd7 223 8 the the DT cord-259669-fod4xkd7 223 9 value value NN cord-259669-fod4xkd7 223 10 of of IN cord-259669-fod4xkd7 223 11 the the DT cord-259669-fod4xkd7 223 12 porcine porcine JJ cord-259669-fod4xkd7 223 13 model model NN cord-259669-fod4xkd7 223 14 for for IN cord-259669-fod4xkd7 223 15 characterizing characterize VBG cord-259669-fod4xkd7 223 16 DC DC NNP cord-259669-fod4xkd7 223 17 from from IN cord-259669-fod4xkd7 223 18 non non JJ cord-259669-fod4xkd7 223 19 - - JJ cord-259669-fod4xkd7 223 20 lymphoid lymphoid JJ cord-259669-fod4xkd7 223 21 organs organ NNS cord-259669-fod4xkd7 223 22 , , , cord-259669-fod4xkd7 223 23 such such JJ cord-259669-fod4xkd7 223 24 as as IN cord-259669-fod4xkd7 223 25 the the DT cord-259669-fod4xkd7 223 26 thyroid thyroid NN cord-259669-fod4xkd7 223 27 DC DC NNP cord-259669-fod4xkd7 223 28 . . . cord-259669-fod4xkd7 224 1 Besides besides IN cord-259669-fod4xkd7 224 2 the the DT cord-259669-fod4xkd7 224 3 more more RBR cord-259669-fod4xkd7 224 4 ' ' '' cord-259669-fod4xkd7 224 5 ' ' `` cord-259669-fod4xkd7 224 6 classical classical JJ cord-259669-fod4xkd7 224 7 ' ' '' cord-259669-fod4xkd7 224 8 ' ' '' cord-259669-fod4xkd7 224 9 APC APC NNP cord-259669-fod4xkd7 224 10 , , , cord-259669-fod4xkd7 224 11 a a DT cord-259669-fod4xkd7 224 12 relatively relatively RB cord-259669-fod4xkd7 224 13 recent recent JJ cord-259669-fod4xkd7 224 14 addition addition NN cord-259669-fod4xkd7 224 15 has have VBZ cord-259669-fod4xkd7 224 16 been be VBN cord-259669-fod4xkd7 224 17 described describe VBN cord-259669-fod4xkd7 224 18 . . . cord-259669-fod4xkd7 225 1 Fibrocytes fibrocyte NNS cord-259669-fod4xkd7 225 2 are be VBP cord-259669-fod4xkd7 225 3 a a DT cord-259669-fod4xkd7 225 4 blood blood NN cord-259669-fod4xkd7 225 5 - - HYPH cord-259669-fod4xkd7 225 6 derived derive VBN cord-259669-fod4xkd7 225 7 cell cell NN cord-259669-fod4xkd7 225 8 population population NN cord-259669-fod4xkd7 225 9 with with IN cord-259669-fod4xkd7 225 10 fibroblastoid fibroblastoid NNP cord-259669-fod4xkd7 225 11 morphology morphology NN cord-259669-fod4xkd7 225 12 , , , cord-259669-fod4xkd7 225 13 which which WDT cord-259669-fod4xkd7 225 14 is be VBZ cord-259669-fod4xkd7 225 15 distinct distinct JJ cord-259669-fod4xkd7 225 16 from from IN cord-259669-fod4xkd7 225 17 DC DC NNP cord-259669-fod4xkd7 225 18 . . . cord-259669-fod4xkd7 226 1 Fibrocytes fibrocyte NNS cord-259669-fod4xkd7 226 2 have have VBP cord-259669-fod4xkd7 226 3 been be VBN cord-259669-fod4xkd7 226 4 described describe VBN cord-259669-fod4xkd7 226 5 for for IN cord-259669-fod4xkd7 226 6 mice mouse NNS cord-259669-fod4xkd7 226 7 , , , cord-259669-fod4xkd7 226 8 humans human NNS cord-259669-fod4xkd7 226 9 and and CC cord-259669-fod4xkd7 226 10 pigs pig NNS cord-259669-fod4xkd7 226 11 [ [ -LRB- cord-259669-fod4xkd7 226 12 25 25 CD cord-259669-fod4xkd7 226 13 , , , cord-259669-fod4xkd7 226 14 79 79 CD cord-259669-fod4xkd7 226 15 , , , cord-259669-fod4xkd7 226 16 80 80 CD cord-259669-fod4xkd7 226 17 ] ] -RRB- cord-259669-fod4xkd7 226 18 , , , cord-259669-fod4xkd7 226 19 and and CC cord-259669-fod4xkd7 226 20 represent represent VB cord-259669-fod4xkd7 226 21 0.5 0.5 CD cord-259669-fod4xkd7 226 22 - - SYM cord-259669-fod4xkd7 226 23 1 1 CD cord-259669-fod4xkd7 226 24 % % NN cord-259669-fod4xkd7 226 25 of of IN cord-259669-fod4xkd7 226 26 nucleated nucleated JJ cord-259669-fod4xkd7 226 27 cells cell NNS cord-259669-fod4xkd7 226 28 in in IN cord-259669-fod4xkd7 226 29 peripheral peripheral JJ cord-259669-fod4xkd7 226 30 blood blood NN cord-259669-fod4xkd7 226 31 . . . cord-259669-fod4xkd7 227 1 They -PRON- PRP cord-259669-fod4xkd7 227 2 express express VBP cord-259669-fod4xkd7 227 3 CD13 CD13 NNP cord-259669-fod4xkd7 227 4 and and CC cord-259669-fod4xkd7 227 5 CD34 CD34 NNP cord-259669-fod4xkd7 227 6 , , , cord-259669-fod4xkd7 227 7 which which WDT cord-259669-fod4xkd7 227 8 would would MD cord-259669-fod4xkd7 227 9 suggest suggest VB cord-259669-fod4xkd7 227 10 a a DT cord-259669-fod4xkd7 227 11 haematopoietic haematopoietic JJ cord-259669-fod4xkd7 227 12 origin origin NN cord-259669-fod4xkd7 227 13 , , , cord-259669-fod4xkd7 227 14 possibly possibly RB cord-259669-fod4xkd7 227 15 myeloid myeloid JJ cord-259669-fod4xkd7 227 16 . . . cord-259669-fod4xkd7 228 1 The the DT cord-259669-fod4xkd7 228 2 presence presence NN cord-259669-fod4xkd7 228 3 of of IN cord-259669-fod4xkd7 228 4 CD14 CD14 NNP cord-259669-fod4xkd7 228 5 , , , cord-259669-fod4xkd7 228 6 CD16 CD16 NNP cord-259669-fod4xkd7 228 7 and and CC cord-259669-fod4xkd7 228 8 CD172a CD172a NNP cord-259669-fod4xkd7 228 9 on on IN cord-259669-fod4xkd7 228 10 porcine porcine JJ cord-259669-fod4xkd7 228 11 fibrocytes fibrocyte NNS cord-259669-fod4xkd7 228 12 [ [ -LRB- cord-259669-fod4xkd7 228 13 25 25 CD cord-259669-fod4xkd7 228 14 ] ] -RRB- cord-259669-fod4xkd7 228 15 , , , cord-259669-fod4xkd7 228 16 and and CC cord-259669-fod4xkd7 228 17 the the DT cord-259669-fod4xkd7 228 18 differentiation differentiation NN cord-259669-fod4xkd7 228 19 of of IN cord-259669-fod4xkd7 228 20 human human JJ cord-259669-fod4xkd7 228 21 fibrocytes fibrocyte NNS cord-259669-fod4xkd7 228 22 in in IN cord-259669-fod4xkd7 228 23 vitro vitro FW cord-259669-fod4xkd7 228 24 from from IN cord-259669-fod4xkd7 228 25 a a DT cord-259669-fod4xkd7 228 26 blood blood NN cord-259669-fod4xkd7 228 27 - - HYPH cord-259669-fod4xkd7 228 28 derived derive VBN cord-259669-fod4xkd7 228 29 CD14 CD14 NNP cord-259669-fod4xkd7 228 30 + + CC cord-259669-fod4xkd7 228 31 population population NN cord-259669-fod4xkd7 228 32 [ [ -LRB- cord-259669-fod4xkd7 228 33 81 81 CD cord-259669-fod4xkd7 228 34 ] ] -RRB- cord-259669-fod4xkd7 228 35 support support NN cord-259669-fod4xkd7 228 36 this this DT cord-259669-fod4xkd7 228 37 hypothesis hypothesis NN cord-259669-fod4xkd7 228 38 . . . cord-259669-fod4xkd7 229 1 Porcine porcine JJ cord-259669-fod4xkd7 229 2 fibrocytes fibrocyte NNS cord-259669-fod4xkd7 229 3 originate originate VBP cord-259669-fod4xkd7 229 4 from from IN cord-259669-fod4xkd7 229 5 a a DT cord-259669-fod4xkd7 229 6 CD163 CD163 NNP cord-259669-fod4xkd7 229 7 + + SYM cord-259669-fod4xkd7 229 8 PBMC PBMC NNP cord-259669-fod4xkd7 229 9 subpopulation subpopulation NN cord-259669-fod4xkd7 229 10 [ [ -LRB- cord-259669-fod4xkd7 229 11 82 82 CD cord-259669-fod4xkd7 229 12 ] ] -RRB- cord-259669-fod4xkd7 229 13 . . . cord-259669-fod4xkd7 230 1 Fibrocytes fibrocyte NNS cord-259669-fod4xkd7 230 2 are be VBP cord-259669-fod4xkd7 230 3 important important JJ cord-259669-fod4xkd7 230 4 during during IN cord-259669-fod4xkd7 230 5 wound wound JJ cord-259669-fod4xkd7 230 6 healing healing NN cord-259669-fod4xkd7 230 7 , , , cord-259669-fod4xkd7 230 8 rapidly rapidly RB cord-259669-fod4xkd7 230 9 entering enter VBG cord-259669-fod4xkd7 230 10 sites site NNS cord-259669-fod4xkd7 230 11 of of IN cord-259669-fod4xkd7 230 12 injury injury NN cord-259669-fod4xkd7 230 13 together together RB cord-259669-fod4xkd7 230 14 with with IN cord-259669-fod4xkd7 230 15 inflammatory inflammatory JJ cord-259669-fod4xkd7 230 16 leukocytes leukocyte NNS cord-259669-fod4xkd7 230 17 [ [ -LRB- cord-259669-fod4xkd7 230 18 80 80 CD cord-259669-fod4xkd7 230 19 ] ] -RRB- cord-259669-fod4xkd7 230 20 . . . cord-259669-fod4xkd7 231 1 They -PRON- PRP cord-259669-fod4xkd7 231 2 are be VBP cord-259669-fod4xkd7 231 3 also also RB cord-259669-fod4xkd7 231 4 an an DT cord-259669-fod4xkd7 231 5 important important JJ cord-259669-fod4xkd7 231 6 source source NN cord-259669-fod4xkd7 231 7 of of IN cord-259669-fod4xkd7 231 8 cytokines cytokine NNS cord-259669-fod4xkd7 231 9 and and CC cord-259669-fod4xkd7 231 10 chemokines chemokine NNS cord-259669-fod4xkd7 231 11 important important JJ cord-259669-fod4xkd7 231 12 for for IN cord-259669-fod4xkd7 231 13 T T NNP cord-259669-fod4xkd7 231 14 lymphocyte lymphocyte NN cord-259669-fod4xkd7 231 15 and and CC cord-259669-fod4xkd7 231 16 DC DC NNP cord-259669-fod4xkd7 231 17 development development NN cord-259669-fod4xkd7 231 18 . . . cord-259669-fod4xkd7 232 1 These these DT cord-259669-fod4xkd7 232 2 include include VBP cord-259669-fod4xkd7 232 3 IL-6 IL-6 NNP cord-259669-fod4xkd7 232 4 , , , cord-259669-fod4xkd7 232 5 IL-10 IL-10 NNP cord-259669-fod4xkd7 232 6 , , , cord-259669-fod4xkd7 232 7 macrophage macrophage NN cord-259669-fod4xkd7 232 8 - - HYPH cord-259669-fod4xkd7 232 9 colony colony NN cord-259669-fod4xkd7 232 10 - - HYPH cord-259669-fod4xkd7 232 11 stimulating stimulate VBG cord-259669-fod4xkd7 232 12 factor factor NN cord-259669-fod4xkd7 232 13 , , , cord-259669-fod4xkd7 232 14 macrophage macrophage NN cord-259669-fod4xkd7 232 15 inflammatory inflammatory JJ cord-259669-fod4xkd7 233 1 protein-1a protein-1a NNP cord-259669-fod4xkd7 233 2 , , , cord-259669-fod4xkd7 233 3 MIP-1b MIP-1b NNP cord-259669-fod4xkd7 233 4 and and CC cord-259669-fod4xkd7 233 5 monocyte monocyte NNP cord-259669-fod4xkd7 233 6 chemoattractant chemoattractant NNP cord-259669-fod4xkd7 233 7 protein-1 protein-1 NNP cord-259669-fod4xkd7 233 8 [ [ -LRB- cord-259669-fod4xkd7 233 9 83 83 CD cord-259669-fod4xkd7 233 10 ] ] -RRB- cord-259669-fod4xkd7 233 11 . . . cord-259669-fod4xkd7 234 1 It -PRON- PRP cord-259669-fod4xkd7 234 2 has have VBZ cord-259669-fod4xkd7 234 3 been be VBN cord-259669-fod4xkd7 234 4 suggested suggest VBN cord-259669-fod4xkd7 234 5 that that IN cord-259669-fod4xkd7 234 6 fibrocytes fibrocyte NNS cord-259669-fod4xkd7 234 7 may may MD cord-259669-fod4xkd7 234 8 play play VB cord-259669-fod4xkd7 234 9 an an DT cord-259669-fod4xkd7 234 10 early early JJ cord-259669-fod4xkd7 234 11 role role NN cord-259669-fod4xkd7 234 12 in in IN cord-259669-fod4xkd7 234 13 the the DT cord-259669-fod4xkd7 234 14 induction induction NN cord-259669-fod4xkd7 234 15 of of IN cord-259669-fod4xkd7 234 16 antigen antigen NN cord-259669-fod4xkd7 234 17 - - HYPH cord-259669-fod4xkd7 234 18 specific specific JJ cord-259669-fod4xkd7 234 19 immunity immunity NN cord-259669-fod4xkd7 234 20 [ [ -LRB- cord-259669-fod4xkd7 234 21 83 83 CD cord-259669-fod4xkd7 234 22 , , , cord-259669-fod4xkd7 234 23 84 84 CD cord-259669-fod4xkd7 234 24 ] ] -RRB- cord-259669-fod4xkd7 234 25 , , , cord-259669-fod4xkd7 234 26 in in IN cord-259669-fod4xkd7 234 27 particular particular JJ cord-259669-fod4xkd7 234 28 the the DT cord-259669-fod4xkd7 234 29 activation activation NN cord-259669-fod4xkd7 234 30 of of IN cord-259669-fod4xkd7 234 31 T T NNP cord-259669-fod4xkd7 234 32 helper helper NN cord-259669-fod4xkd7 234 33 lymphocytes lymphocyte NNS cord-259669-fod4xkd7 234 34 [ [ -LRB- cord-259669-fod4xkd7 234 35 80 80 CD cord-259669-fod4xkd7 234 36 ] ] -RRB- cord-259669-fod4xkd7 234 37 . . . cord-259669-fod4xkd7 235 1 Porcine porcine JJ cord-259669-fod4xkd7 235 2 fibrocytes fibrocyte NNS cord-259669-fod4xkd7 235 3 were be VBD cord-259669-fod4xkd7 235 4 also also RB cord-259669-fod4xkd7 235 5 shown show VBN cord-259669-fod4xkd7 235 6 to to TO cord-259669-fod4xkd7 235 7 be be VB cord-259669-fod4xkd7 235 8 potent potent JJ cord-259669-fod4xkd7 235 9 APC APC NNP cord-259669-fod4xkd7 235 10 , , , cord-259669-fod4xkd7 235 11 relating relate VBG cord-259669-fod4xkd7 235 12 to to IN cord-259669-fod4xkd7 235 13 their -PRON- PRP$ cord-259669-fod4xkd7 235 14 expression expression NN cord-259669-fod4xkd7 235 15 of of IN cord-259669-fod4xkd7 235 16 MHC MHC NNP cord-259669-fod4xkd7 235 17 class class NN cord-259669-fod4xkd7 235 18 II II NNP cord-259669-fod4xkd7 235 19 , , , cord-259669-fod4xkd7 235 20 CD1 CD1 NNP cord-259669-fod4xkd7 235 21 and and CC cord-259669-fod4xkd7 235 22 CD80 CD80 NNP cord-259669-fod4xkd7 235 23 / / SYM cord-259669-fod4xkd7 235 24 CD86 CD86 NNP cord-259669-fod4xkd7 235 25 , , , cord-259669-fod4xkd7 235 26 as as RB cord-259669-fod4xkd7 235 27 well well RB cord-259669-fod4xkd7 235 28 as as IN cord-259669-fod4xkd7 235 29 their -PRON- PRP$ cord-259669-fod4xkd7 235 30 endocytic endocytic JJ cord-259669-fod4xkd7 235 31 activity activity NN cord-259669-fod4xkd7 235 32 [ [ -LRB- cord-259669-fod4xkd7 235 33 25 25 CD cord-259669-fod4xkd7 235 34 ] ] -RRB- cord-259669-fod4xkd7 235 35 . . . cord-259669-fod4xkd7 236 1 These these DT cord-259669-fod4xkd7 236 2 cells cell NNS cord-259669-fod4xkd7 236 3 activate activate VBP cord-259669-fod4xkd7 236 4 CD4 CD4 NNP cord-259669-fod4xkd7 236 5 + + CC cord-259669-fod4xkd7 236 6 T t NN cord-259669-fod4xkd7 236 7 cells cell NNS cord-259669-fod4xkd7 236 8 , , , cord-259669-fod4xkd7 236 9 but but CC cord-259669-fod4xkd7 236 10 also also RB cord-259669-fod4xkd7 236 11 efficiently efficiently RB cord-259669-fod4xkd7 236 12 stimulate stimulate VBP cord-259669-fod4xkd7 236 13 virus virus NN cord-259669-fod4xkd7 236 14 - - HYPH cord-259669-fod4xkd7 236 15 specific specific JJ cord-259669-fod4xkd7 236 16 CD8 CD8 NNP cord-259669-fod4xkd7 236 17 + + SYM cord-259669-fod4xkd7 236 18 CTL CTL NNP cord-259669-fod4xkd7 236 19 . . . cord-259669-fod4xkd7 237 1 In in IN cord-259669-fod4xkd7 237 2 fact fact NN cord-259669-fod4xkd7 237 3 , , , cord-259669-fod4xkd7 237 4 fibrocytes fibrocyte NNS cord-259669-fod4xkd7 237 5 are be VBP cord-259669-fod4xkd7 237 6 effective effective JJ cord-259669-fod4xkd7 237 7 at at IN cord-259669-fod4xkd7 237 8 low low JJ cord-259669-fod4xkd7 237 9 ratios ratio NNS cord-259669-fod4xkd7 237 10 with with IN cord-259669-fod4xkd7 237 11 T t NN cord-259669-fod4xkd7 237 12 lymphocytes lymphocyte NNS cord-259669-fod4xkd7 237 13 , , , cord-259669-fod4xkd7 237 14 ratios ratio NNS cord-259669-fod4xkd7 237 15 at at IN cord-259669-fod4xkd7 237 16 which which WDT cord-259669-fod4xkd7 237 17 MoDC MoDC NNP cord-259669-fod4xkd7 237 18 are be VBP cord-259669-fod4xkd7 237 19 less less RBR cord-259669-fod4xkd7 237 20 efficient efficient JJ cord-259669-fod4xkd7 237 21 [ [ -LRB- cord-259669-fod4xkd7 237 22 25 25 CD cord-259669-fod4xkd7 237 23 ] ] -RRB- cord-259669-fod4xkd7 237 24 . . . cord-259669-fod4xkd7 238 1 Porcine porcine JJ cord-259669-fod4xkd7 238 2 fibrocytes fibrocyte NNS cord-259669-fod4xkd7 238 3 also also RB cord-259669-fod4xkd7 238 4 respond respond VBP cord-259669-fod4xkd7 238 5 to to IN cord-259669-fod4xkd7 238 6 TLR TLR NNP cord-259669-fod4xkd7 238 7 ligands ligand NNS cord-259669-fod4xkd7 238 8 by by IN cord-259669-fod4xkd7 238 9 producing produce VBG cord-259669-fod4xkd7 238 10 large large JJ cord-259669-fod4xkd7 238 11 quantities quantity NNS cord-259669-fod4xkd7 238 12 of of IN cord-259669-fod4xkd7 238 13 IL-6 IL-6 NNP cord-259669-fod4xkd7 238 14 [ [ -LRB- cord-259669-fod4xkd7 238 15 82 82 CD cord-259669-fod4xkd7 238 16 ] ] -RRB- cord-259669-fod4xkd7 238 17 . . . cord-259669-fod4xkd7 239 1 These these DT cord-259669-fod4xkd7 239 2 TLR TLR NNP cord-259669-fod4xkd7 239 3 ligands ligand NNS cord-259669-fod4xkd7 239 4 include include VBP cord-259669-fod4xkd7 239 5 LPS LPS NNP cord-259669-fod4xkd7 239 6 ( ( -LRB- cord-259669-fod4xkd7 239 7 TLR4-ligand TLR4-ligand NNP cord-259669-fod4xkd7 239 8 ) ) -RRB- cord-259669-fod4xkd7 239 9 , , , cord-259669-fod4xkd7 239 10 lipopeptide lipopeptide NNP cord-259669-fod4xkd7 239 11 ( ( -LRB- cord-259669-fod4xkd7 239 12 diacylated diacylate VBN cord-259669-fod4xkd7 239 13 form form NN cord-259669-fod4xkd7 239 14 recognized recognize VBN cord-259669-fod4xkd7 239 15 by by IN cord-259669-fod4xkd7 239 16 TLR1 TLR1 NNP cord-259669-fod4xkd7 239 17 / / SYM cord-259669-fod4xkd7 239 18 TLR2 TLR2 NNP cord-259669-fod4xkd7 239 19 heterodimers heterodimer NNS cord-259669-fod4xkd7 239 20 ; ; , cord-259669-fod4xkd7 239 21 triacylated triacylated JJ cord-259669-fod4xkd7 239 22 form form NN cord-259669-fod4xkd7 239 23 recognized recognize VBN cord-259669-fod4xkd7 239 24 by by IN cord-259669-fod4xkd7 239 25 TLR2/ TLR2/ NNP cord-259669-fod4xkd7 239 26 TLR6 TLR6 NNP cord-259669-fod4xkd7 239 27 heterodimers heterodimer NNS cord-259669-fod4xkd7 239 28 ) ) -RRB- cord-259669-fod4xkd7 239 29 , , , cord-259669-fod4xkd7 239 30 and and CC cord-259669-fod4xkd7 239 31 TLR7 TLR7 NNP cord-259669-fod4xkd7 239 32 ligands ligand NNS cord-259669-fod4xkd7 239 33 [ [ -LRB- cord-259669-fod4xkd7 239 34 82 82 CD cord-259669-fod4xkd7 239 35 ] ] -RRB- cord-259669-fod4xkd7 239 36 . . . cord-259669-fod4xkd7 240 1 The the DT cord-259669-fod4xkd7 240 2 importance importance NN cord-259669-fod4xkd7 240 3 of of IN cord-259669-fod4xkd7 240 4 DC DC NNP cord-259669-fod4xkd7 240 5 within within IN cord-259669-fod4xkd7 240 6 the the DT cord-259669-fod4xkd7 240 7 innate innate JJ cord-259669-fod4xkd7 240 8 immune immune JJ cord-259669-fod4xkd7 240 9 system system NN cord-259669-fod4xkd7 240 10 is be VBZ cord-259669-fod4xkd7 240 11 due due JJ cord-259669-fod4xkd7 240 12 to to IN cord-259669-fod4xkd7 240 13 their -PRON- PRP$ cord-259669-fod4xkd7 240 14 recognition recognition NN cord-259669-fod4xkd7 240 15 of of IN cord-259669-fod4xkd7 240 16 PAMPs pamp NNS cord-259669-fod4xkd7 240 17 through through IN cord-259669-fod4xkd7 240 18 their -PRON- PRP$ cord-259669-fod4xkd7 240 19 PRRs prr NNS cord-259669-fod4xkd7 240 20 . . . cord-259669-fod4xkd7 241 1 TLR TLR NNP cord-259669-fod4xkd7 241 2 play play VBP cord-259669-fod4xkd7 241 3 a a DT cord-259669-fod4xkd7 241 4 central central JJ cord-259669-fod4xkd7 241 5 role role NN cord-259669-fod4xkd7 241 6 in in IN cord-259669-fod4xkd7 241 7 this this DT cord-259669-fod4xkd7 241 8 concept concept NN cord-259669-fod4xkd7 241 9 of of IN cord-259669-fod4xkd7 241 10 innate innate JJ cord-259669-fod4xkd7 241 11 immune immune JJ cord-259669-fod4xkd7 241 12 recognition recognition NN cord-259669-fod4xkd7 241 13 . . . cord-259669-fod4xkd7 242 1 This this DT cord-259669-fod4xkd7 242 2 results result VBZ cord-259669-fod4xkd7 242 3 in in IN cord-259669-fod4xkd7 242 4 a a DT cord-259669-fod4xkd7 242 5 robust robust JJ cord-259669-fod4xkd7 242 6 cytokine cytokine NN cord-259669-fod4xkd7 242 7 and and CC cord-259669-fod4xkd7 242 8 chemokine chemokine NN cord-259669-fod4xkd7 242 9 response response NN cord-259669-fod4xkd7 242 10 , , , cord-259669-fod4xkd7 242 11 along along IN cord-259669-fod4xkd7 242 12 with with IN cord-259669-fod4xkd7 242 13 DC DC NNP cord-259669-fod4xkd7 242 14 activation activation NN cord-259669-fod4xkd7 242 15 and and CC cord-259669-fod4xkd7 242 16 maturation maturation NN cord-259669-fod4xkd7 242 17 , , , cord-259669-fod4xkd7 242 18 all all DT cord-259669-fod4xkd7 242 19 essential essential JJ cord-259669-fod4xkd7 242 20 for for IN cord-259669-fod4xkd7 242 21 adaptive adaptive JJ cord-259669-fod4xkd7 242 22 immune immune JJ cord-259669-fod4xkd7 242 23 response response NN cord-259669-fod4xkd7 242 24 development development NN cord-259669-fod4xkd7 242 25 ( ( -LRB- cord-259669-fod4xkd7 242 26 Fig Fig NNP cord-259669-fod4xkd7 242 27 . . NNP cord-259669-fod4xkd7 242 28 2 2 CD cord-259669-fod4xkd7 242 29 ) ) -RRB- cord-259669-fod4xkd7 242 30 . . . cord-259669-fod4xkd7 243 1 A a DT cord-259669-fod4xkd7 243 2 simplified simplified JJ cord-259669-fod4xkd7 243 3 concept concept NN cord-259669-fod4xkd7 243 4 is be VBZ cord-259669-fod4xkd7 243 5 that that IN cord-259669-fod4xkd7 243 6 antigen antigen NN cord-259669-fod4xkd7 243 7 presentation presentation NN cord-259669-fod4xkd7 243 8 in in IN cord-259669-fod4xkd7 243 9 the the DT cord-259669-fod4xkd7 243 10 absence absence NN cord-259669-fod4xkd7 243 11 of of IN cord-259669-fod4xkd7 243 12 DC DC NNP cord-259669-fod4xkd7 243 13 activation activation NN cord-259669-fod4xkd7 243 14 leads lead VBZ cord-259669-fod4xkd7 243 15 to to IN cord-259669-fod4xkd7 243 16 tolerance tolerance NN cord-259669-fod4xkd7 243 17 or or CC cord-259669-fod4xkd7 243 18 shortlived shortlived JJ cord-259669-fod4xkd7 243 19 immune immune JJ cord-259669-fod4xkd7 243 20 responses response NNS cord-259669-fod4xkd7 243 21 without without IN cord-259669-fod4xkd7 243 22 immunological immunological JJ cord-259669-fod4xkd7 243 23 memory memory NN cord-259669-fod4xkd7 243 24 development development NN cord-259669-fod4xkd7 243 25 [ [ -LRB- cord-259669-fod4xkd7 243 26 85 85 CD cord-259669-fod4xkd7 243 27 ] ] -RRB- cord-259669-fod4xkd7 243 28 . . . cord-259669-fod4xkd7 244 1 The the DT cord-259669-fod4xkd7 244 2 current current JJ cord-259669-fod4xkd7 244 3 evidence evidence NN cord-259669-fod4xkd7 244 4 shows show VBZ cord-259669-fod4xkd7 244 5 that that IN cord-259669-fod4xkd7 244 6 concomitant concomitant JJ cord-259669-fod4xkd7 244 7 recognition recognition NN cord-259669-fod4xkd7 244 8 of of IN cord-259669-fod4xkd7 244 9 the the DT cord-259669-fod4xkd7 244 10 antigen antigen NN cord-259669-fod4xkd7 244 11 and and CC cord-259669-fod4xkd7 244 12 a a DT cord-259669-fod4xkd7 244 13 ' ' '' cord-259669-fod4xkd7 244 14 ' ' `` cord-259669-fod4xkd7 244 15 danger danger NN cord-259669-fod4xkd7 244 16 ' ' '' cord-259669-fod4xkd7 244 17 ' ' '' cord-259669-fod4xkd7 244 18 signal signal NN cord-259669-fod4xkd7 244 19 is be VBZ cord-259669-fod4xkd7 244 20 essential essential JJ cord-259669-fod4xkd7 244 21 for for IN cord-259669-fod4xkd7 244 22 the the DT cord-259669-fod4xkd7 244 23 DC DC NNP cord-259669-fod4xkd7 244 24 to to TO cord-259669-fod4xkd7 244 25 promote promote VB cord-259669-fod4xkd7 244 26 adaptive adaptive JJ cord-259669-fod4xkd7 244 27 immune immune JJ cord-259669-fod4xkd7 244 28 defence defence NN cord-259669-fod4xkd7 244 29 development development NN cord-259669-fod4xkd7 244 30 [ [ -LRB- cord-259669-fod4xkd7 244 31 86 86 CD cord-259669-fod4xkd7 244 32 ] ] -RRB- cord-259669-fod4xkd7 244 33 . . . cord-259669-fod4xkd7 245 1 With with IN cord-259669-fod4xkd7 245 2 self self NN cord-259669-fod4xkd7 245 3 and and CC cord-259669-fod4xkd7 245 4 food food NN cord-259669-fod4xkd7 245 5 antigens antigen NNS cord-259669-fod4xkd7 245 6 , , , cord-259669-fod4xkd7 245 7 the the DT cord-259669-fod4xkd7 245 8 absence absence NN cord-259669-fod4xkd7 245 9 of of IN cord-259669-fod4xkd7 245 10 the the DT cord-259669-fod4xkd7 245 11 ' ' `` cord-259669-fod4xkd7 245 12 ' ' `` cord-259669-fod4xkd7 245 13 danger danger NN cord-259669-fod4xkd7 245 14 ' ' '' cord-259669-fod4xkd7 245 15 ' ' '' cord-259669-fod4xkd7 245 16 signal signal NN cord-259669-fod4xkd7 245 17 ensure ensure NN cord-259669-fod4xkd7 245 18 that that IN cord-259669-fod4xkd7 245 19 the the DT cord-259669-fod4xkd7 245 20 DC DC NNP cord-259669-fod4xkd7 245 21 involved involve VBN cord-259669-fod4xkd7 245 22 are be VBP cord-259669-fod4xkd7 245 23 tolerogenic tolerogenic JJ cord-259669-fod4xkd7 245 24 . . . cord-259669-fod4xkd7 246 1 For for IN cord-259669-fod4xkd7 246 2 efficacious efficacious JJ cord-259669-fod4xkd7 246 3 immune immune JJ cord-259669-fod4xkd7 246 4 defence defence NN cord-259669-fod4xkd7 246 5 development development NN cord-259669-fod4xkd7 246 6 , , , cord-259669-fod4xkd7 246 7 the the DT cord-259669-fod4xkd7 246 8 cell cell NN cord-259669-fod4xkd7 246 9 subsetspecific subsetspecific NNP cord-259669-fod4xkd7 246 10 recognition recognition NN cord-259669-fod4xkd7 246 11 of of IN cord-259669-fod4xkd7 246 12 PAMPs PAMPs NNP cord-259669-fod4xkd7 246 13 plays play VBZ cord-259669-fod4xkd7 246 14 a a DT cord-259669-fod4xkd7 246 15 critical critical JJ cord-259669-fod4xkd7 246 16 role role NN cord-259669-fod4xkd7 246 17 , , , cord-259669-fod4xkd7 246 18 resulting result VBG cord-259669-fod4xkd7 246 19 in in IN cord-259669-fod4xkd7 246 20 the the DT cord-259669-fod4xkd7 246 21 DC DC NNP cord-259669-fod4xkd7 246 22 - - HYPH cord-259669-fod4xkd7 246 23 derived derive VBN cord-259669-fod4xkd7 246 24 cytokines cytokine NNS cord-259669-fod4xkd7 246 25 necessary necessary JJ cord-259669-fod4xkd7 246 26 for for IN cord-259669-fod4xkd7 246 27 both both CC cord-259669-fod4xkd7 246 28 the the DT cord-259669-fod4xkd7 246 29 innate innate JJ cord-259669-fod4xkd7 246 30 response response NN cord-259669-fod4xkd7 246 31 and and CC cord-259669-fod4xkd7 246 32 the the DT cord-259669-fod4xkd7 246 33 strength strength NN cord-259669-fod4xkd7 246 34 and and CC cord-259669-fod4xkd7 246 35 quality quality NN cord-259669-fod4xkd7 246 36 of of IN cord-259669-fod4xkd7 246 37 the the DT cord-259669-fod4xkd7 246 38 adaptive adaptive JJ cord-259669-fod4xkd7 246 39 response response NN cord-259669-fod4xkd7 246 40 . . . cord-259669-fod4xkd7 247 1 In in IN cord-259669-fod4xkd7 247 2 addition addition NN cord-259669-fod4xkd7 247 3 to to IN cord-259669-fod4xkd7 247 4 phenotypic phenotypic VB cord-259669-fod4xkd7 247 5 differences difference NNS cord-259669-fod4xkd7 247 6 , , , cord-259669-fod4xkd7 247 7 it -PRON- PRP cord-259669-fod4xkd7 247 8 is be VBZ cord-259669-fod4xkd7 247 9 also also RB cord-259669-fod4xkd7 247 10 in in IN cord-259669-fod4xkd7 247 11 this this DT cord-259669-fod4xkd7 247 12 area area NN cord-259669-fod4xkd7 247 13 of of IN cord-259669-fod4xkd7 247 14 PAMP PAMP NNP cord-259669-fod4xkd7 247 15 recognition recognition NN cord-259669-fod4xkd7 247 16 that that IN cord-259669-fod4xkd7 247 17 species species NN cord-259669-fod4xkd7 247 18 - - HYPH cord-259669-fod4xkd7 247 19 dependent dependent JJ cord-259669-fod4xkd7 247 20 differences difference NNS cord-259669-fod4xkd7 247 21 are be VBP cord-259669-fod4xkd7 247 22 observed observe VBN cord-259669-fod4xkd7 247 23 . . . cord-259669-fod4xkd7 248 1 Consequently consequently RB cord-259669-fod4xkd7 248 2 , , , cord-259669-fod4xkd7 248 3 it -PRON- PRP cord-259669-fod4xkd7 248 4 is be VBZ cord-259669-fod4xkd7 248 5 important important JJ cord-259669-fod4xkd7 248 6 to to TO cord-259669-fod4xkd7 248 7 understand understand VB cord-259669-fod4xkd7 248 8 how how WRB cord-259669-fod4xkd7 248 9 porcine porcine JJ cord-259669-fod4xkd7 248 10 APC APC NNP cord-259669-fod4xkd7 248 11 recognition recognition NN cord-259669-fod4xkd7 248 12 of of IN cord-259669-fod4xkd7 248 13 PAMP PAMP NNP cord-259669-fod4xkd7 248 14 compared compare VBN cord-259669-fod4xkd7 248 15 with with IN cord-259669-fod4xkd7 248 16 human human JJ cord-259669-fod4xkd7 248 17 APC APC NNP cord-259669-fod4xkd7 248 18 , , , cord-259669-fod4xkd7 248 19 and and CC cord-259669-fod4xkd7 248 20 to to TO cord-259669-fod4xkd7 248 21 determine determine VB cord-259669-fod4xkd7 248 22 the the DT cord-259669-fod4xkd7 248 23 distribution distribution NN cord-259669-fod4xkd7 248 24 of of IN cord-259669-fod4xkd7 248 25 TLR TLR NNP cord-259669-fod4xkd7 248 26 within within IN cord-259669-fod4xkd7 248 27 the the DT cord-259669-fod4xkd7 248 28 porcine porcine JJ cord-259669-fod4xkd7 248 29 DC DC NNP cord-259669-fod4xkd7 248 30 system system NN cord-259669-fod4xkd7 248 31 . . . cord-259669-fod4xkd7 249 1 In in IN cord-259669-fod4xkd7 249 2 Fig Fig NNP cord-259669-fod4xkd7 249 3 . . NNP cord-259669-fod4xkd7 249 4 2 2 CD cord-259669-fod4xkd7 249 5 , , , cord-259669-fod4xkd7 249 6 a a DT cord-259669-fod4xkd7 249 7 schematic schematic JJ cord-259669-fod4xkd7 249 8 overview overview NN cord-259669-fod4xkd7 249 9 of of IN cord-259669-fod4xkd7 249 10 the the DT cord-259669-fod4xkd7 249 11 functional functional JJ cord-259669-fod4xkd7 249 12 specialization specialization NN cord-259669-fod4xkd7 249 13 and and CC cord-259669-fod4xkd7 249 14 cytokine cytokine NN cord-259669-fod4xkd7 249 15 production production NN cord-259669-fod4xkd7 249 16 of of IN cord-259669-fod4xkd7 249 17 porcine porcine JJ cord-259669-fod4xkd7 249 18 cDC cDC NNS cord-259669-fod4xkd7 249 19 and and CC cord-259669-fod4xkd7 249 20 pDC pDC NNP cord-259669-fod4xkd7 249 21 is be VBZ cord-259669-fod4xkd7 249 22 represented represent VBN cord-259669-fod4xkd7 249 23 . . . cord-259669-fod4xkd7 250 1 The the DT cord-259669-fod4xkd7 250 2 current current JJ cord-259669-fod4xkd7 250 3 knowledge knowledge NN cord-259669-fod4xkd7 250 4 on on IN cord-259669-fod4xkd7 250 5 the the DT cord-259669-fod4xkd7 250 6 cytokine cytokine NN cord-259669-fod4xkd7 250 7 responses response NNS cord-259669-fod4xkd7 250 8 of of IN cord-259669-fod4xkd7 250 9 MoDC MoDC NNP cord-259669-fod4xkd7 250 10 is be VBZ cord-259669-fod4xkd7 250 11 also also RB cord-259669-fod4xkd7 250 12 included include VBN cord-259669-fod4xkd7 250 13 in in IN cord-259669-fod4xkd7 250 14 the the DT cord-259669-fod4xkd7 250 15 overview overview NN cord-259669-fod4xkd7 250 16 provided provide VBN cord-259669-fod4xkd7 250 17 by by IN cord-259669-fod4xkd7 250 18 Table Table NNP cord-259669-fod4xkd7 250 19 3 3 CD cord-259669-fod4xkd7 250 20 . . . cord-259669-fod4xkd7 251 1 One one CD cord-259669-fod4xkd7 251 2 of of IN cord-259669-fod4xkd7 251 3 the the DT cord-259669-fod4xkd7 251 4 important important JJ cord-259669-fod4xkd7 251 5 responses response NNS cord-259669-fod4xkd7 251 6 induced induce VBN cord-259669-fod4xkd7 251 7 by by IN cord-259669-fod4xkd7 251 8 TLR TLR NNP cord-259669-fod4xkd7 251 9 ligation ligation NN cord-259669-fod4xkd7 251 10 on on IN cord-259669-fod4xkd7 251 11 DC DC NNP cord-259669-fod4xkd7 251 12 is be VBZ cord-259669-fod4xkd7 251 13 the the DT cord-259669-fod4xkd7 251 14 induction induction NN cord-259669-fod4xkd7 251 15 of of IN cord-259669-fod4xkd7 251 16 maturation maturation NN cord-259669-fod4xkd7 251 17 . . . cord-259669-fod4xkd7 252 1 As as IN cord-259669-fod4xkd7 252 2 a a DT cord-259669-fod4xkd7 252 3 simple simple JJ cord-259669-fod4xkd7 252 4 read read NN cord-259669-fod4xkd7 252 5 - - HYPH cord-259669-fod4xkd7 252 6 out out NN cord-259669-fod4xkd7 252 7 of of IN cord-259669-fod4xkd7 252 8 this this DT cord-259669-fod4xkd7 252 9 process process NN cord-259669-fod4xkd7 252 10 increased increase VBN cord-259669-fod4xkd7 252 11 levels level NNS cord-259669-fod4xkd7 252 12 of of IN cord-259669-fod4xkd7 252 13 surface surface NN cord-259669-fod4xkd7 252 14 molecules molecule NNS cord-259669-fod4xkd7 252 15 involved involve VBN cord-259669-fod4xkd7 252 16 in in IN cord-259669-fod4xkd7 252 17 antigen antigen NN cord-259669-fod4xkd7 252 18 presentation presentation NN cord-259669-fod4xkd7 252 19 such such JJ cord-259669-fod4xkd7 252 20 as as IN cord-259669-fod4xkd7 252 21 MHC MHC NNP cord-259669-fod4xkd7 252 22 class class NN cord-259669-fod4xkd7 252 23 II II NNP cord-259669-fod4xkd7 252 24 , , , cord-259669-fod4xkd7 252 25 CD40 CD40 NNP cord-259669-fod4xkd7 252 26 and and CC cord-259669-fod4xkd7 252 27 CD80/86 CD80/86 NNP cord-259669-fod4xkd7 252 28 are be VBP cord-259669-fod4xkd7 252 29 often often RB cord-259669-fod4xkd7 252 30 used use VBN cord-259669-fod4xkd7 252 31 . . . cord-259669-fod4xkd7 253 1 Nevertheless nevertheless RB cord-259669-fod4xkd7 253 2 , , , cord-259669-fod4xkd7 253 3 the the DT cord-259669-fod4xkd7 253 4 interpretations interpretation NNS cord-259669-fod4xkd7 253 5 of of IN cord-259669-fod4xkd7 253 6 such such JJ cord-259669-fod4xkd7 253 7 results result NNS cord-259669-fod4xkd7 253 8 alone alone RB cord-259669-fod4xkd7 253 9 do do VBP cord-259669-fod4xkd7 253 10 not not RB cord-259669-fod4xkd7 253 11 permit permit VB cord-259669-fod4xkd7 253 12 definitive definitive JJ cord-259669-fod4xkd7 253 13 conclusions conclusion NNS cord-259669-fod4xkd7 253 14 on on IN cord-259669-fod4xkd7 253 15 the the DT cord-259669-fod4xkd7 253 16 maturation maturation NN cord-259669-fod4xkd7 253 17 status status NN cord-259669-fod4xkd7 253 18 of of IN cord-259669-fod4xkd7 253 19 a a DT cord-259669-fod4xkd7 253 20 DC DC NNP cord-259669-fod4xkd7 253 21 in in IN cord-259669-fod4xkd7 253 22 terms term NNS cord-259669-fod4xkd7 253 23 of of IN cord-259669-fod4xkd7 253 24 T t NN cord-259669-fod4xkd7 253 25 - - HYPH cord-259669-fod4xkd7 253 26 cell cell NN cord-259669-fod4xkd7 253 27 stimulatory stimulatory JJ cord-259669-fod4xkd7 253 28 activities activity NNS cord-259669-fod4xkd7 253 29 [ [ -LRB- cord-259669-fod4xkd7 253 30 19 19 CD cord-259669-fod4xkd7 253 31 ] ] -RRB- cord-259669-fod4xkd7 253 32 . . . cord-259669-fod4xkd7 254 1 Porcine porcine JJ cord-259669-fod4xkd7 254 2 MoDC MoDC NNP cord-259669-fod4xkd7 254 3 as as IN cord-259669-fod4xkd7 254 4 a a DT cord-259669-fod4xkd7 254 5 model model NN cord-259669-fod4xkd7 254 6 of of IN cord-259669-fod4xkd7 254 7 cDC cDC NNS cord-259669-fod4xkd7 254 8 relate relate VB cord-259669-fod4xkd7 254 9 to to IN cord-259669-fod4xkd7 254 10 those those DT cord-259669-fod4xkd7 254 11 from from IN cord-259669-fod4xkd7 254 12 other other JJ cord-259669-fod4xkd7 254 13 species specie NNS cord-259669-fod4xkd7 254 14 in in IN cord-259669-fod4xkd7 254 15 their -PRON- PRP$ cord-259669-fod4xkd7 254 16 response response NN cord-259669-fod4xkd7 254 17 to to IN cord-259669-fod4xkd7 254 18 TLR TLR NNP cord-259669-fod4xkd7 254 19 ligands ligand NNS cord-259669-fod4xkd7 254 20 by by IN cord-259669-fod4xkd7 254 21 upregulation upregulation NN cord-259669-fod4xkd7 254 22 of of IN cord-259669-fod4xkd7 254 23 MHC MHC NNP cord-259669-fod4xkd7 254 24 and and CC cord-259669-fod4xkd7 254 25 CD80/86 CD80/86 NNP cord-259669-fod4xkd7 254 26 ( ( -LRB- cord-259669-fod4xkd7 254 27 Table Table NNP cord-259669-fod4xkd7 254 28 3 3 CD cord-259669-fod4xkd7 254 29 ) ) -RRB- cord-259669-fod4xkd7 254 30 . . . cord-259669-fod4xkd7 255 1 These these DT cord-259669-fod4xkd7 255 2 include include VBP cord-259669-fod4xkd7 255 3 TLR2 TLR2 NNP cord-259669-fod4xkd7 255 4 ligands ligand NNS cord-259669-fod4xkd7 255 5 Pam3Cys Pam3Cys NNP cord-259669-fod4xkd7 255 6 lipopeptide lipopeptide NNP cord-259669-fod4xkd7 255 7 , , , cord-259669-fod4xkd7 255 8 pseudomonas pseudomonas NNP cord-259669-fod4xkd7 255 9 OprI OprI NNP cord-259669-fod4xkd7 255 10 lipoprotein lipoprotein NNP cord-259669-fod4xkd7 255 11 , , , cord-259669-fod4xkd7 255 12 lipoteichoic lipoteichoic NNP cord-259669-fod4xkd7 255 13 acid acid NN cord-259669-fod4xkd7 255 14 ( ( -LRB- cord-259669-fod4xkd7 255 15 LTA LTA NNP cord-259669-fod4xkd7 255 16 ) ) -RRB- cord-259669-fod4xkd7 255 17 and and CC cord-259669-fod4xkd7 255 18 peptidoglycan peptidoglycan NN cord-259669-fod4xkd7 255 19 [ [ -LRB- cord-259669-fod4xkd7 255 20 27 27 CD cord-259669-fod4xkd7 255 21 , , , cord-259669-fod4xkd7 255 22 35 35 CD cord-259669-fod4xkd7 255 23 ] ] -RRB- cord-259669-fod4xkd7 255 24 , , , cord-259669-fod4xkd7 255 25 TLR3 TLR3 NNP cord-259669-fod4xkd7 255 26 ligands ligand NNS cord-259669-fod4xkd7 255 27 such such JJ cord-259669-fod4xkd7 255 28 as as IN cord-259669-fod4xkd7 255 29 synthetic synthetic JJ cord-259669-fod4xkd7 255 30 doublestranded doublestranded NNP cord-259669-fod4xkd7 255 31 ( ( -LRB- cord-259669-fod4xkd7 255 32 ds ds NNP cord-259669-fod4xkd7 255 33 ) ) -RRB- cord-259669-fod4xkd7 255 34 RNA RNA NNP cord-259669-fod4xkd7 255 35 polyinosinic polyinosinic NNP cord-259669-fod4xkd7 255 36 - - HYPH cord-259669-fod4xkd7 255 37 polycytidylic polycytidylic NN cord-259669-fod4xkd7 255 38 acid acid NN cord-259669-fod4xkd7 255 39 ( ( -LRB- cord-259669-fod4xkd7 255 40 polyIC polyIC NNP cord-259669-fod4xkd7 255 41 ) ) -RRB- cord-259669-fod4xkd7 255 42 [ [ -LRB- cord-259669-fod4xkd7 255 43 27 27 CD cord-259669-fod4xkd7 255 44 , , , cord-259669-fod4xkd7 255 45 28 28 CD cord-259669-fod4xkd7 255 46 , , , cord-259669-fod4xkd7 255 47 36 36 CD cord-259669-fod4xkd7 255 48 , , , cord-259669-fod4xkd7 255 49 87 87 CD cord-259669-fod4xkd7 255 50 ] ] -RRB- cord-259669-fod4xkd7 255 51 , , , cord-259669-fod4xkd7 255 52 TLR4 TLR4 NNP cord-259669-fod4xkd7 255 53 ligand ligand NN cord-259669-fod4xkd7 255 54 lipopolysaccharide lipopolysaccharide NN cord-259669-fod4xkd7 255 55 ( ( -LRB- cord-259669-fod4xkd7 255 56 LPS LPS NNP cord-259669-fod4xkd7 255 57 ) ) -RRB- cord-259669-fod4xkd7 255 58 [ [ -LRB- cord-259669-fod4xkd7 256 1 23 23 CD cord-259669-fod4xkd7 256 2 , , , cord-259669-fod4xkd7 256 3 24 24 CD cord-259669-fod4xkd7 256 4 , , , cord-259669-fod4xkd7 256 5 27 27 CD cord-259669-fod4xkd7 256 6 ] ] -RRB- cord-259669-fod4xkd7 256 7 and and CC cord-259669-fod4xkd7 256 8 the the DT cord-259669-fod4xkd7 256 9 TLR7 TLR7 NNP cord-259669-fod4xkd7 256 10 ligands ligand NNS cord-259669-fod4xkd7 256 11 R837 r837 POS cord-259669-fod4xkd7 256 12 and and CC cord-259669-fod4xkd7 256 13 polyuridylic polyuridylic NN cord-259669-fod4xkd7 256 14 acid acid NN cord-259669-fod4xkd7 256 15 [ [ -LRB- cord-259669-fod4xkd7 256 16 38 38 CD cord-259669-fod4xkd7 256 17 ] ] -RRB- cord-259669-fod4xkd7 256 18 . . . cord-259669-fod4xkd7 257 1 Similar similar JJ cord-259669-fod4xkd7 257 2 to to IN cord-259669-fod4xkd7 257 3 human human JJ cord-259669-fod4xkd7 257 4 DC DC NNP cord-259669-fod4xkd7 257 5 , , , cord-259669-fod4xkd7 257 6 both both DT cord-259669-fod4xkd7 257 7 porcine porcine JJ cord-259669-fod4xkd7 257 8 MoDC modc NN cord-259669-fod4xkd7 257 9 and and CC cord-259669-fod4xkd7 257 10 blood blood NN cord-259669-fod4xkd7 257 11 cDC cDC NNS cord-259669-fod4xkd7 257 12 have have VBP cord-259669-fod4xkd7 257 13 been be VBN cord-259669-fod4xkd7 257 14 reported report VBN cord-259669-fod4xkd7 257 15 to to TO cord-259669-fod4xkd7 257 16 be be VB cord-259669-fod4xkd7 257 17 unreceptive unreceptive JJ cord-259669-fod4xkd7 257 18 to to IN cord-259669-fod4xkd7 257 19 the the DT cord-259669-fod4xkd7 257 20 TLR9 tlr9 JJ cord-259669-fod4xkd7 257 21 ligand ligand NN cord-259669-fod4xkd7 257 22 CpG cpg NN cord-259669-fod4xkd7 257 23 - - HYPH cord-259669-fod4xkd7 257 24 ODN ODN NNP cord-259669-fod4xkd7 257 25 , , , cord-259669-fod4xkd7 257 26 when when WRB cord-259669-fod4xkd7 257 27 analysed analyse VBN cord-259669-fod4xkd7 257 28 for for IN cord-259669-fod4xkd7 257 29 MHC MHC NNP cord-259669-fod4xkd7 257 30 class class NN cord-259669-fod4xkd7 257 31 II II NNP cord-259669-fod4xkd7 257 32 and and CC cord-259669-fod4xkd7 257 33 CD80/86 cd80/86 CD cord-259669-fod4xkd7 257 34 expression expression NN cord-259669-fod4xkd7 257 35 [ [ -LRB- cord-259669-fod4xkd7 257 36 58 58 CD cord-259669-fod4xkd7 257 37 ] ] -RRB- cord-259669-fod4xkd7 257 38 . . . cord-259669-fod4xkd7 258 1 Nevertheless nevertheless RB cord-259669-fod4xkd7 258 2 , , , cord-259669-fod4xkd7 258 3 MoDC MoDC NNP cord-259669-fod4xkd7 258 4 express express VB cord-259669-fod4xkd7 258 5 TLR9 TLR9 NNP cord-259669-fod4xkd7 258 6 mRNA mrna NN cord-259669-fod4xkd7 258 7 [ [ -LRB- cord-259669-fod4xkd7 258 8 27 27 CD cord-259669-fod4xkd7 258 9 , , , cord-259669-fod4xkd7 258 10 38 38 CD cord-259669-fod4xkd7 258 11 ] ] -RRB- cord-259669-fod4xkd7 258 12 , , , cord-259669-fod4xkd7 258 13 and and CC cord-259669-fod4xkd7 258 14 CpG CpG NNP cord-259669-fod4xkd7 258 15 - - HYPH cord-259669-fod4xkd7 258 16 ODN ODN NNP cord-259669-fod4xkd7 258 17 can can MD cord-259669-fod4xkd7 258 18 induce induce VB cord-259669-fod4xkd7 258 19 the the DT cord-259669-fod4xkd7 258 20 mRNA mrna NN cord-259669-fod4xkd7 258 21 of of IN cord-259669-fod4xkd7 258 22 TLR4 TLR4 NNP cord-259669-fod4xkd7 258 23 , , , cord-259669-fod4xkd7 258 24 TLR9 TLR9 NNP cord-259669-fod4xkd7 258 25 , , , cord-259669-fod4xkd7 258 26 IFN IFN NNP cord-259669-fod4xkd7 258 27 - - HYPH cord-259669-fod4xkd7 258 28 g g NNP cord-259669-fod4xkd7 258 29 and and CC cord-259669-fod4xkd7 258 30 IL12 IL12 NNP cord-259669-fod4xkd7 258 31 p35 p35 CD cord-259669-fod4xkd7 258 32 , , , cord-259669-fod4xkd7 258 33 as as RB cord-259669-fod4xkd7 258 34 well well RB cord-259669-fod4xkd7 258 35 as as IN cord-259669-fod4xkd7 258 36 increased increase VBN cord-259669-fod4xkd7 258 37 levels level NNS cord-259669-fod4xkd7 258 38 MHC MHC NNP cord-259669-fod4xkd7 258 39 class class NN cord-259669-fod4xkd7 258 40 II II NNP cord-259669-fod4xkd7 258 41 as as RB cord-259669-fod4xkd7 258 42 well well RB cord-259669-fod4xkd7 258 43 as as IN cord-259669-fod4xkd7 258 44 CD80/86 cd80/86 CD cord-259669-fod4xkd7 258 45 [ [ -LRB- cord-259669-fod4xkd7 258 46 27 27 CD cord-259669-fod4xkd7 258 47 ] ] -RRB- cord-259669-fod4xkd7 258 48 . . . cord-259669-fod4xkd7 259 1 Such such JJ cord-259669-fod4xkd7 259 2 discrepancies discrepancy NNS cord-259669-fod4xkd7 259 3 between between IN cord-259669-fod4xkd7 259 4 the the DT cord-259669-fod4xkd7 259 5 studies study NNS cord-259669-fod4xkd7 259 6 may may MD cord-259669-fod4xkd7 259 7 have have VB cord-259669-fod4xkd7 259 8 been be VBN cord-259669-fod4xkd7 259 9 caused cause VBN cord-259669-fod4xkd7 259 10 by by IN cord-259669-fod4xkd7 259 11 sequence sequence NN cord-259669-fod4xkd7 259 12 differences difference NNS cord-259669-fod4xkd7 259 13 in in IN cord-259669-fod4xkd7 259 14 the the DT cord-259669-fod4xkd7 259 15 ODN ODN NNP cord-259669-fod4xkd7 259 16 employed employ VBN cord-259669-fod4xkd7 259 17 or or CC cord-259669-fod4xkd7 259 18 may may MD cord-259669-fod4xkd7 259 19 reflect reflect VB cord-259669-fod4xkd7 259 20 differences difference NNS cord-259669-fod4xkd7 259 21 in in IN cord-259669-fod4xkd7 259 22 the the DT cord-259669-fod4xkd7 259 23 responsive responsive JJ cord-259669-fod4xkd7 259 24 status status NN cord-259669-fod4xkd7 259 25 of of IN cord-259669-fod4xkd7 259 26 the the DT cord-259669-fod4xkd7 259 27 cells cell NNS cord-259669-fod4xkd7 259 28 employed employ VBN cord-259669-fod4xkd7 259 29 . . . cord-259669-fod4xkd7 260 1 For for IN cord-259669-fod4xkd7 260 2 example example NN cord-259669-fod4xkd7 260 3 , , , cord-259669-fod4xkd7 260 4 the the DT cord-259669-fod4xkd7 260 5 relatively relatively RB cord-259669-fod4xkd7 260 6 modest modest JJ cord-259669-fod4xkd7 260 7 increase increase NN cord-259669-fod4xkd7 260 8 of of IN cord-259669-fod4xkd7 260 9 CD80/86 cd80/86 CD cord-259669-fod4xkd7 260 10 and and CC cord-259669-fod4xkd7 260 11 MHC MHC NNP cord-259669-fod4xkd7 260 12 class class NN cord-259669-fod4xkd7 260 13 II ii CD cord-259669-fod4xkd7 260 14 expression expression NN cord-259669-fod4xkd7 260 15 on on IN cord-259669-fod4xkd7 260 16 MoDC modc NN cord-259669-fod4xkd7 260 17 after after IN cord-259669-fod4xkd7 260 18 TLR TLR NNP cord-259669-fod4xkd7 260 19 stimulation stimulation NN cord-259669-fod4xkd7 260 20 is be VBZ cord-259669-fod4xkd7 260 21 synergistically synergistically RB cord-259669-fod4xkd7 260 22 enhanced enhance VBN cord-259669-fod4xkd7 260 23 in in IN cord-259669-fod4xkd7 260 24 the the DT cord-259669-fod4xkd7 260 25 presence presence NN cord-259669-fod4xkd7 260 26 of of IN cord-259669-fod4xkd7 260 27 IFN IFN NNP cord-259669-fod4xkd7 260 28 - - : cord-259669-fod4xkd7 260 29 a a DT cord-259669-fod4xkd7 260 30 [ [ -LRB- cord-259669-fod4xkd7 260 31 64 64 CD cord-259669-fod4xkd7 260 32 ] ] -RRB- cord-259669-fod4xkd7 260 33 . . . cord-259669-fod4xkd7 261 1 In in IN cord-259669-fod4xkd7 261 2 this this DT cord-259669-fod4xkd7 261 3 study study NN cord-259669-fod4xkd7 261 4 it -PRON- PRP cord-259669-fod4xkd7 261 5 was be VBD cord-259669-fod4xkd7 261 6 also also RB cord-259669-fod4xkd7 261 7 shown show VBN cord-259669-fod4xkd7 261 8 that that IN cord-259669-fod4xkd7 261 9 a a DT cord-259669-fod4xkd7 261 10 full full JJ cord-259669-fod4xkd7 261 11 phenotypic phenotypic JJ cord-259669-fod4xkd7 261 12 maturation maturation NN cord-259669-fod4xkd7 261 13 only only RB cord-259669-fod4xkd7 261 14 occurred occur VBD cord-259669-fod4xkd7 261 15 during during IN cord-259669-fod4xkd7 261 16 antigen antigen NN cord-259669-fod4xkd7 261 17 presentation presentation NN cord-259669-fod4xkd7 261 18 to to IN cord-259669-fod4xkd7 261 19 T t NN cord-259669-fod4xkd7 261 20 lymphocytes lymphocyte NNS cord-259669-fod4xkd7 261 21 . . . cord-259669-fod4xkd7 262 1 We -PRON- PRP cord-259669-fod4xkd7 262 2 have have VBP cord-259669-fod4xkd7 262 3 also also RB cord-259669-fod4xkd7 262 4 observed observe VBN cord-259669-fod4xkd7 262 5 that that IN cord-259669-fod4xkd7 262 6 in in IN cord-259669-fod4xkd7 262 7 contrast contrast NN cord-259669-fod4xkd7 262 8 to to IN cord-259669-fod4xkd7 262 9 MoDC MoDC NNP cord-259669-fod4xkd7 262 10 , , , cord-259669-fod4xkd7 262 11 Flt3-ligand Flt3-ligand NNP cord-259669-fod4xkd7 262 12 derived derive VBN cord-259669-fod4xkd7 262 13 BMDC BMDC NNP cord-259669-fod4xkd7 262 14 are be VBP cord-259669-fod4xkd7 262 15 clearly clearly RB cord-259669-fod4xkd7 262 16 more more JJR cord-259669-fod4xkd7 262 17 responsiveness responsiveness NN cord-259669-fod4xkd7 262 18 to to IN cord-259669-fod4xkd7 262 19 a a DT cord-259669-fod4xkd7 262 20 range range NN cord-259669-fod4xkd7 262 21 of of IN cord-259669-fod4xkd7 262 22 TLR TLR NNP cord-259669-fod4xkd7 262 23 ligands ligand NNS cord-259669-fod4xkd7 262 24 including include VBG cord-259669-fod4xkd7 262 25 TLR2 TLR2 NNP cord-259669-fod4xkd7 262 26 , , , cord-259669-fod4xkd7 262 27 3 3 CD cord-259669-fod4xkd7 262 28 , , , cord-259669-fod4xkd7 262 29 4 4 CD cord-259669-fod4xkd7 262 30 , , , cord-259669-fod4xkd7 262 31 7 7 CD cord-259669-fod4xkd7 262 32 and and CC cord-259669-fod4xkd7 262 33 9 9 CD cord-259669-fod4xkd7 262 34 ( ( -LRB- cord-259669-fod4xkd7 262 35 Guzylack Guzylack NNP cord-259669-fod4xkd7 262 36 - - HYPH cord-259669-fod4xkd7 262 37 Piriou Piriou NNP cord-259669-fod4xkd7 262 38 and and CC cord-259669-fod4xkd7 262 39 Summerfield Summerfield NNP cord-259669-fod4xkd7 262 40 , , , cord-259669-fod4xkd7 262 41 unpublished unpublished JJ cord-259669-fod4xkd7 262 42 data datum NNS cord-259669-fod4xkd7 262 43 ) ) -RRB- cord-259669-fod4xkd7 262 44 . . . cord-259669-fod4xkd7 263 1 TLR TLR NNP cord-259669-fod4xkd7 263 2 ligation ligation NN cord-259669-fod4xkd7 263 3 can can MD cord-259669-fod4xkd7 263 4 induce induce VB cord-259669-fod4xkd7 263 5 cytokine cytokine NN cord-259669-fod4xkd7 263 6 mRNA mrna NN cord-259669-fod4xkd7 263 7 species specie NNS cord-259669-fod4xkd7 263 8 for for IN cord-259669-fod4xkd7 264 1 IL-10 IL-10 NNP cord-259669-fod4xkd7 264 2 , , , cord-259669-fod4xkd7 264 3 IL-12p35 IL-12p35 NNP cord-259669-fod4xkd7 264 4 , , , cord-259669-fod4xkd7 264 5 IL-13 IL-13 NNP cord-259669-fod4xkd7 264 6 and and CC cord-259669-fod4xkd7 264 7 IFN IFN NNP cord-259669-fod4xkd7 264 8 - - HYPH cord-259669-fod4xkd7 264 9 g g NNP cord-259669-fod4xkd7 264 10 in in IN cord-259669-fod4xkd7 264 11 DC DC NNP cord-259669-fod4xkd7 264 12 , , , cord-259669-fod4xkd7 264 13 although although IN cord-259669-fod4xkd7 264 14 this this DT cord-259669-fod4xkd7 264 15 depends depend VBZ cord-259669-fod4xkd7 264 16 on on IN cord-259669-fod4xkd7 264 17 the the DT cord-259669-fod4xkd7 264 18 TLR TLR NNP cord-259669-fod4xkd7 264 19 ligand ligand NN cord-259669-fod4xkd7 264 20 employed employ VBD cord-259669-fod4xkd7 264 21 [ [ -LRB- cord-259669-fod4xkd7 264 22 27 27 CD cord-259669-fod4xkd7 264 23 ] ] -RRB- cord-259669-fod4xkd7 264 24 . . . cord-259669-fod4xkd7 265 1 While while IN cord-259669-fod4xkd7 265 2 polyIC polyIC NNP cord-259669-fod4xkd7 265 3 , , , cord-259669-fod4xkd7 265 4 LPS LPS NNP cord-259669-fod4xkd7 265 5 , , , cord-259669-fod4xkd7 265 6 LTA LTA NNP cord-259669-fod4xkd7 265 7 , , , cord-259669-fod4xkd7 265 8 and and CC cord-259669-fod4xkd7 265 9 CpG CpG NNP cord-259669-fod4xkd7 265 10 induced induce VBD cord-259669-fod4xkd7 265 11 the the DT cord-259669-fod4xkd7 265 12 Th1 th1 NN cord-259669-fod4xkd7 265 13 promoting promote VBG cord-259669-fod4xkd7 265 14 cytokines cytokine NNS cord-259669-fod4xkd7 265 15 IL12 IL12 NNP cord-259669-fod4xkd7 265 16 and and CC cord-259669-fod4xkd7 265 17 IFN IFN NNP cord-259669-fod4xkd7 265 18 - - HYPH cord-259669-fod4xkd7 265 19 g g NNP cord-259669-fod4xkd7 265 20 , , , cord-259669-fod4xkd7 265 21 the the DT cord-259669-fod4xkd7 265 22 Th2-like th2-like JJ cord-259669-fod4xkd7 265 23 cytokines cytokine NNS cord-259669-fod4xkd7 265 24 IL-10 IL-10 NNP cord-259669-fod4xkd7 265 25 and and CC cord-259669-fod4xkd7 266 1 IL-13 IL-13 NNP cord-259669-fod4xkd7 266 2 were be VBD cord-259669-fod4xkd7 266 3 induced induce VBN cord-259669-fod4xkd7 266 4 only only RB cord-259669-fod4xkd7 266 5 by by IN cord-259669-fod4xkd7 266 6 LPS LPS NNP cord-259669-fod4xkd7 266 7 and and CC cord-259669-fod4xkd7 266 8 LTA LTA NNP cord-259669-fod4xkd7 266 9 ( ( -LRB- cord-259669-fod4xkd7 266 10 Table Table NNP cord-259669-fod4xkd7 266 11 3 3 CD cord-259669-fod4xkd7 266 12 ) ) -RRB- cord-259669-fod4xkd7 266 13 . . . cord-259669-fod4xkd7 267 1 Raymond Raymond NNP cord-259669-fod4xkd7 267 2 et et NNP cord-259669-fod4xkd7 267 3 al al NNP cord-259669-fod4xkd7 267 4 . . . cord-259669-fod4xkd7 268 1 [ [ -LRB- cord-259669-fod4xkd7 268 2 27 27 CD cord-259669-fod4xkd7 268 3 ] ] -RRB- cord-259669-fod4xkd7 268 4 also also RB cord-259669-fod4xkd7 268 5 demonstrated demonstrate VBD cord-259669-fod4xkd7 268 6 that that IN cord-259669-fod4xkd7 268 7 similar similar JJ cord-259669-fod4xkd7 268 8 to to IN cord-259669-fod4xkd7 268 9 human human JJ cord-259669-fod4xkd7 268 10 and and CC cord-259669-fod4xkd7 268 11 mouse mouse NN cord-259669-fod4xkd7 268 12 DC DC NNP cord-259669-fod4xkd7 268 13 , , , cord-259669-fod4xkd7 268 14 the the DT cord-259669-fod4xkd7 268 15 cytokine cytokine NN cord-259669-fod4xkd7 268 16 response response NN cord-259669-fod4xkd7 268 17 of of IN cord-259669-fod4xkd7 268 18 porcine porcine JJ cord-259669-fod4xkd7 268 19 DC DC NNP cord-259669-fod4xkd7 268 20 can can MD cord-259669-fod4xkd7 268 21 be be VB cord-259669-fod4xkd7 268 22 modulated modulate VBN cord-259669-fod4xkd7 268 23 by by IN cord-259669-fod4xkd7 268 24 cytokines cytokine NNS cord-259669-fod4xkd7 268 25 . . . cord-259669-fod4xkd7 269 1 For for IN cord-259669-fod4xkd7 269 2 example example NN cord-259669-fod4xkd7 269 3 , , , cord-259669-fod4xkd7 269 4 IL-12p35 IL-12p35 NNP cord-259669-fod4xkd7 269 5 mRNA mrna NN cord-259669-fod4xkd7 269 6 can can MD cord-259669-fod4xkd7 269 7 be be VB cord-259669-fod4xkd7 269 8 enhanced enhance VBN cord-259669-fod4xkd7 269 9 with with IN cord-259669-fod4xkd7 269 10 TNF TNF NNP cord-259669-fod4xkd7 269 11 - - HYPH cord-259669-fod4xkd7 269 12 a a NNP cord-259669-fod4xkd7 269 13 , , , cord-259669-fod4xkd7 269 14 IL-12 IL-12 NNP cord-259669-fod4xkd7 269 15 and and CC cord-259669-fod4xkd7 269 16 IFN IFN NNP cord-259669-fod4xkd7 269 17 - - HYPH cord-259669-fod4xkd7 269 18 g g NN cord-259669-fod4xkd7 269 19 and and CC cord-259669-fod4xkd7 269 20 reduced reduce VBN cord-259669-fod4xkd7 269 21 with with IN cord-259669-fod4xkd7 269 22 IL-10 IL-10 NNP cord-259669-fod4xkd7 269 23 treatment treatment NN cord-259669-fod4xkd7 269 24 of of IN cord-259669-fod4xkd7 269 25 DC DC NNP cord-259669-fod4xkd7 269 26 . . . cord-259669-fod4xkd7 270 1 Along along IN cord-259669-fod4xkd7 270 2 the the DT cord-259669-fod4xkd7 270 3 same same JJ cord-259669-fod4xkd7 270 4 line line NN cord-259669-fod4xkd7 270 5 , , , cord-259669-fod4xkd7 270 6 the the DT cord-259669-fod4xkd7 270 7 Th1 th1 CD cord-259669-fod4xkd7 270 8 / / SYM cord-259669-fod4xkd7 270 9 Th2 th2 CD cord-259669-fod4xkd7 270 10 cytokine cytokine NN cord-259669-fod4xkd7 270 11 profile profile NN cord-259669-fod4xkd7 270 12 will will MD cord-259669-fod4xkd7 270 13 depend depend VB cord-259669-fod4xkd7 270 14 on on IN cord-259669-fod4xkd7 270 15 the the DT cord-259669-fod4xkd7 270 16 type type NN cord-259669-fod4xkd7 270 17 of of IN cord-259669-fod4xkd7 270 18 antigen antigen NN cord-259669-fod4xkd7 270 19 encountered encounter VBD cord-259669-fod4xkd7 270 20 [ [ -LRB- cord-259669-fod4xkd7 270 21 88 88 CD cord-259669-fod4xkd7 270 22 ] ] -RRB- cord-259669-fod4xkd7 270 23 . . . cord-259669-fod4xkd7 271 1 At at IN cord-259669-fod4xkd7 271 2 the the DT cord-259669-fod4xkd7 271 3 protein protein NN cord-259669-fod4xkd7 271 4 level level NN cord-259669-fod4xkd7 271 5 MoDC modc NN cord-259669-fod4xkd7 271 6 have have VBP cord-259669-fod4xkd7 271 7 been be VBN cord-259669-fod4xkd7 271 8 reported report VBN cord-259669-fod4xkd7 271 9 to to TO cord-259669-fod4xkd7 271 10 produce produce VB cord-259669-fod4xkd7 271 11 TNF TNF NNP cord-259669-fod4xkd7 271 12 - - : cord-259669-fod4xkd7 271 13 a a NNP cord-259669-fod4xkd7 271 14 and and CC cord-259669-fod4xkd7 271 15 IL-6 IL-6 NNP cord-259669-fod4xkd7 271 16 after after IN cord-259669-fod4xkd7 271 17 stimulation stimulation NN cord-259669-fod4xkd7 271 18 with with IN cord-259669-fod4xkd7 271 19 poly(IC poly(ic CD cord-259669-fod4xkd7 271 20 ) ) -RRB- cord-259669-fod4xkd7 271 21 , , , cord-259669-fod4xkd7 271 22 LPS LPS NNP cord-259669-fod4xkd7 271 23 , , , cord-259669-fod4xkd7 271 24 OprI OprI NNP cord-259669-fod4xkd7 271 25 and and CC cord-259669-fod4xkd7 271 26 Pam3Cys Pam3Cys NNP cord-259669-fod4xkd7 271 27 ( ( -LRB- cord-259669-fod4xkd7 271 28 both both DT cord-259669-fod4xkd7 271 29 TLR2 TLR2 NNP cord-259669-fod4xkd7 271 30 ligands ligand NNS cord-259669-fod4xkd7 271 31 ) ) -RRB- cord-259669-fod4xkd7 271 32 , , , cord-259669-fod4xkd7 271 33 while while IN cord-259669-fod4xkd7 271 34 production production NN cord-259669-fod4xkd7 271 35 of of IN cord-259669-fod4xkd7 271 36 IL-10 IL-10 NNP cord-259669-fod4xkd7 271 37 and and CC cord-259669-fod4xkd7 271 38 IL-12 IL-12 NNP cord-259669-fod4xkd7 271 39 has have VBZ cord-259669-fod4xkd7 271 40 been be VBN cord-259669-fod4xkd7 271 41 difficult difficult JJ cord-259669-fod4xkd7 271 42 to to TO cord-259669-fod4xkd7 271 43 detect detect VB cord-259669-fod4xkd7 271 44 by by IN cord-259669-fod4xkd7 271 45 ELISA ELISA NNP cord-259669-fod4xkd7 271 46 [ [ -LRB- cord-259669-fod4xkd7 271 47 34 34 CD cord-259669-fod4xkd7 271 48 , , , cord-259669-fod4xkd7 271 49 35 35 CD cord-259669-fod4xkd7 271 50 , , , cord-259669-fod4xkd7 271 51 75 75 CD cord-259669-fod4xkd7 271 52 , , , cord-259669-fod4xkd7 271 53 87 87 CD cord-259669-fod4xkd7 271 54 ] ] -RRB- cord-259669-fod4xkd7 271 55 . . . cord-259669-fod4xkd7 272 1 Related relate VBN cord-259669-fod4xkd7 272 2 to to IN cord-259669-fod4xkd7 272 3 the the DT cord-259669-fod4xkd7 272 4 stimulation stimulation NN cord-259669-fod4xkd7 272 5 by by IN cord-259669-fod4xkd7 272 6 these these DT cord-259669-fod4xkd7 272 7 specific specific JJ cord-259669-fod4xkd7 272 8 TLR TLR NNP cord-259669-fod4xkd7 272 9 ligands ligand NNS cord-259669-fod4xkd7 272 10 is be VBZ cord-259669-fod4xkd7 272 11 the the DT cord-259669-fod4xkd7 272 12 cytokine cytokine JJ cord-259669-fod4xkd7 272 13 response response NN cord-259669-fod4xkd7 272 14 of of IN cord-259669-fod4xkd7 272 15 MoDC MoDC NNP cord-259669-fod4xkd7 272 16 to to TO cord-259669-fod4xkd7 272 17 heat heat NN cord-259669-fod4xkd7 272 18 - - HYPH cord-259669-fod4xkd7 272 19 inactivated inactivate VBN cord-259669-fod4xkd7 272 20 Actinobacillus Actinobacillus NNP cord-259669-fod4xkd7 272 21 pleuropneumoniae pleuropneumoniae NN cord-259669-fod4xkd7 272 22 in in IN cord-259669-fod4xkd7 272 23 terms term NNS cord-259669-fod4xkd7 272 24 of of IN cord-259669-fod4xkd7 272 25 IL-6 IL-6 NNP cord-259669-fod4xkd7 272 26 , , , cord-259669-fod4xkd7 272 27 IL-10 IL-10 NNP cord-259669-fod4xkd7 272 28 and and CC cord-259669-fod4xkd7 272 29 IL-12 IL-12 NNP cord-259669-fod4xkd7 272 30 secretion secretion NN cord-259669-fod4xkd7 272 31 [ [ -LRB- cord-259669-fod4xkd7 272 32 26 26 CD cord-259669-fod4xkd7 272 33 ] ] -RRB- cord-259669-fod4xkd7 272 34 . . . cord-259669-fod4xkd7 273 1 MoDC MoDC NNP cord-259669-fod4xkd7 273 2 also also RB cord-259669-fod4xkd7 273 3 produce produce VB cord-259669-fod4xkd7 273 4 type type NN cord-259669-fod4xkd7 274 1 I -PRON- PRP cord-259669-fod4xkd7 274 2 IFN IFN NNP cord-259669-fod4xkd7 274 3 after after IN cord-259669-fod4xkd7 274 4 stimulation stimulation NN cord-259669-fod4xkd7 274 5 with with IN cord-259669-fod4xkd7 274 6 poly(IC poly(ic CD cord-259669-fod4xkd7 274 7 ) ) -RRB- cord-259669-fod4xkd7 274 8 and and CC cord-259669-fod4xkd7 274 9 mRNA mrna NN cord-259669-fod4xkd7 274 10 transfection transfection NN cord-259669-fod4xkd7 274 11 [ [ -LRB- cord-259669-fod4xkd7 274 12 28 28 CD cord-259669-fod4xkd7 274 13 , , , cord-259669-fod4xkd7 274 14 36 36 CD cord-259669-fod4xkd7 274 15 , , , cord-259669-fod4xkd7 274 16 87 87 CD cord-259669-fod4xkd7 274 17 ] ] -RRB- cord-259669-fod4xkd7 274 18 . . . cord-259669-fod4xkd7 275 1 The the DT cord-259669-fod4xkd7 275 2 latter latter JJ cord-259669-fod4xkd7 275 3 is be VBZ cord-259669-fod4xkd7 275 4 dependent dependent JJ cord-259669-fod4xkd7 275 5 on on IN cord-259669-fod4xkd7 275 6 the the DT cord-259669-fod4xkd7 275 7 secondary secondary JJ cord-259669-fod4xkd7 275 8 structure structure NN cord-259669-fod4xkd7 275 9 of of IN cord-259669-fod4xkd7 275 10 the the DT cord-259669-fod4xkd7 275 11 mRNA mRNA NNP cord-259669-fod4xkd7 275 12 molecule molecule NN cord-259669-fod4xkd7 275 13 forming form VBG cord-259669-fod4xkd7 275 14 dsRNA dsrna NN cord-259669-fod4xkd7 275 15 structures structure NNS cord-259669-fod4xkd7 275 16 [ [ -LRB- cord-259669-fod4xkd7 275 17 36 36 CD cord-259669-fod4xkd7 275 18 ] ] -RRB- cord-259669-fod4xkd7 275 19 . . . cord-259669-fod4xkd7 276 1 It -PRON- PRP cord-259669-fod4xkd7 276 2 is be VBZ cord-259669-fod4xkd7 276 3 important important JJ cord-259669-fod4xkd7 276 4 to to TO cord-259669-fod4xkd7 276 5 note note VB cord-259669-fod4xkd7 276 6 that that IN cord-259669-fod4xkd7 276 7 MoDC modc JJ cord-259669-fod4xkd7 276 8 maturation maturation NN cord-259669-fod4xkd7 276 9 and and CC cord-259669-fod4xkd7 276 10 cytokine cytokine NN cord-259669-fod4xkd7 276 11 production production NN cord-259669-fod4xkd7 276 12 is be VBZ cord-259669-fod4xkd7 276 13 highly highly RB cord-259669-fod4xkd7 276 14 variable variable JJ cord-259669-fod4xkd7 276 15 and and CC cord-259669-fod4xkd7 276 16 subject subject JJ cord-259669-fod4xkd7 276 17 to to IN cord-259669-fod4xkd7 276 18 immunomodulation immunomodulation NN cord-259669-fod4xkd7 276 19 . . . cord-259669-fod4xkd7 277 1 Another another DT cord-259669-fod4xkd7 277 2 example example NN cord-259669-fod4xkd7 277 3 for for IN cord-259669-fod4xkd7 277 4 this this DT cord-259669-fod4xkd7 277 5 is be VBZ cord-259669-fod4xkd7 277 6 the the DT cord-259669-fod4xkd7 277 7 observation observation NN cord-259669-fod4xkd7 277 8 that that IN cord-259669-fod4xkd7 277 9 RA RA NNP cord-259669-fod4xkd7 277 10 has have VBZ cord-259669-fod4xkd7 277 11 a a DT cord-259669-fod4xkd7 277 12 potent potent JJ cord-259669-fod4xkd7 277 13 synergistic synergistic JJ cord-259669-fod4xkd7 277 14 effect effect NN cord-259669-fod4xkd7 277 15 on on IN cord-259669-fod4xkd7 277 16 IL-6 IL-6 NNP cord-259669-fod4xkd7 277 17 secretion secretion NN cord-259669-fod4xkd7 277 18 induced induce VBN cord-259669-fod4xkd7 277 19 by by IN cord-259669-fod4xkd7 277 20 TLR TLR NNP cord-259669-fod4xkd7 277 21 ligands ligand NNS cord-259669-fod4xkd7 277 22 [ [ -LRB- cord-259669-fod4xkd7 277 23 75 75 CD cord-259669-fod4xkd7 277 24 ] ] -RRB- cord-259669-fod4xkd7 277 25 . . . cord-259669-fod4xkd7 278 1 This this DT cord-259669-fod4xkd7 278 2 relates relate VBZ cord-259669-fod4xkd7 278 3 to to IN cord-259669-fod4xkd7 278 4 the the DT cord-259669-fod4xkd7 278 5 fact fact NN cord-259669-fod4xkd7 278 6 that that IN cord-259669-fod4xkd7 278 7 the the DT cord-259669-fod4xkd7 278 8 DC DC NNP cord-259669-fod4xkd7 278 9 family family NN cord-259669-fod4xkd7 278 10 has have VBZ cord-259669-fod4xkd7 278 11 a a DT cord-259669-fod4xkd7 278 12 high high JJ cord-259669-fod4xkd7 278 13 diversity diversity NN cord-259669-fod4xkd7 278 14 to to TO cord-259669-fod4xkd7 278 15 deal deal VB cord-259669-fod4xkd7 278 16 with with IN cord-259669-fod4xkd7 278 17 the the DT cord-259669-fod4xkd7 278 18 varying vary VBG cord-259669-fod4xkd7 278 19 environments environment NNS cord-259669-fod4xkd7 278 20 and and CC cord-259669-fod4xkd7 278 21 signals signal NNS cord-259669-fod4xkd7 278 22 it -PRON- PRP cord-259669-fod4xkd7 278 23 receives receive VBZ cord-259669-fod4xkd7 278 24 in in IN cord-259669-fod4xkd7 278 25 vivo vivo NN cord-259669-fod4xkd7 278 26 from from IN cord-259669-fod4xkd7 278 27 the the DT cord-259669-fod4xkd7 278 28 local local JJ cord-259669-fod4xkd7 278 29 tissue tissue NN cord-259669-fod4xkd7 278 30 environment environment NN cord-259669-fod4xkd7 278 31 and and CC cord-259669-fod4xkd7 278 32 from from IN cord-259669-fod4xkd7 278 33 pathogens pathogen NNS cord-259669-fod4xkd7 278 34 . . . cord-259669-fod4xkd7 279 1 With with IN cord-259669-fod4xkd7 279 2 in in FW cord-259669-fod4xkd7 279 3 vitro vitro FW cord-259669-fod4xkd7 279 4 analyses analysis NNS cord-259669-fod4xkd7 279 5 , , , cord-259669-fod4xkd7 279 6 it -PRON- PRP cord-259669-fod4xkd7 279 7 is be VBZ cord-259669-fod4xkd7 279 8 only only RB cord-259669-fod4xkd7 279 9 possible possible JJ cord-259669-fod4xkd7 279 10 to to TO cord-259669-fod4xkd7 279 11 reproduce reproduce VB cord-259669-fod4xkd7 279 12 a a DT cord-259669-fod4xkd7 279 13 small small JJ cord-259669-fod4xkd7 279 14 fraction fraction NN cord-259669-fod4xkd7 279 15 of of IN cord-259669-fod4xkd7 279 16 this this DT cord-259669-fod4xkd7 279 17 diverse diverse JJ cord-259669-fod4xkd7 279 18 scene scene NN cord-259669-fod4xkd7 279 19 . . . cord-259669-fod4xkd7 280 1 Therefore therefore RB cord-259669-fod4xkd7 280 2 , , , cord-259669-fod4xkd7 280 3 what what WP cord-259669-fod4xkd7 280 4 we -PRON- PRP cord-259669-fod4xkd7 280 5 are be VBP cord-259669-fod4xkd7 280 6 observing observe VBG cord-259669-fod4xkd7 280 7 in in IN cord-259669-fod4xkd7 280 8 vitro vitro FW cord-259669-fod4xkd7 280 9 is be VBZ cord-259669-fod4xkd7 280 10 true true JJ cord-259669-fod4xkd7 280 11 for for IN cord-259669-fod4xkd7 280 12 the the DT cord-259669-fod4xkd7 280 13 conditions condition NNS cord-259669-fod4xkd7 280 14 being be VBG cord-259669-fod4xkd7 280 15 created create VBN cord-259669-fod4xkd7 280 16 , , , cord-259669-fod4xkd7 280 17 but but CC cord-259669-fod4xkd7 280 18 can can MD cord-259669-fod4xkd7 280 19 not not RB cord-259669-fod4xkd7 280 20 be be VB cord-259669-fod4xkd7 280 21 taken take VBN cord-259669-fod4xkd7 280 22 as as IN cord-259669-fod4xkd7 280 23 a a DT cord-259669-fod4xkd7 280 24 general general JJ cord-259669-fod4xkd7 280 25 rule rule NN cord-259669-fod4xkd7 280 26 for for IN cord-259669-fod4xkd7 280 27 all all DT cord-259669-fod4xkd7 280 28 DC DC NNP cord-259669-fod4xkd7 280 29 subsets subset NNS cord-259669-fod4xkd7 280 30 under under IN cord-259669-fod4xkd7 280 31 all all DT cord-259669-fod4xkd7 280 32 conditions condition NNS cord-259669-fod4xkd7 280 33 in in IN cord-259669-fod4xkd7 280 34 vivo vivo NN cord-259669-fod4xkd7 280 35 . . . cord-259669-fod4xkd7 281 1 As as IN cord-259669-fod4xkd7 281 2 with with IN cord-259669-fod4xkd7 281 3 cDC cDC NNP cord-259669-fod4xkd7 281 4 , , , cord-259669-fod4xkd7 281 5 the the DT cord-259669-fod4xkd7 281 6 pDC pDC NNP cord-259669-fod4xkd7 281 7 can can MD cord-259669-fod4xkd7 281 8 also also RB cord-259669-fod4xkd7 281 9 upregulate upregulate VB cord-259669-fod4xkd7 281 10 MHC MHC NNP cord-259669-fod4xkd7 281 11 class class NN cord-259669-fod4xkd7 281 12 II II NNP cord-259669-fod4xkd7 281 13 and and CC cord-259669-fod4xkd7 281 14 costimulatory costimulatory NN cord-259669-fod4xkd7 281 15 molecules molecule NNS cord-259669-fod4xkd7 281 16 after after IN cord-259669-fod4xkd7 281 17 in in IN cord-259669-fod4xkd7 281 18 vitro vitro FW cord-259669-fod4xkd7 281 19 culture culture NN cord-259669-fod4xkd7 281 20 [ [ -LRB- cord-259669-fod4xkd7 281 21 40 40 CD cord-259669-fod4xkd7 281 22 ] ] -RRB- cord-259669-fod4xkd7 281 23 and and CC cord-259669-fod4xkd7 281 24 when when WRB cord-259669-fod4xkd7 281 25 stimulated stimulate VBN cord-259669-fod4xkd7 281 26 with with IN cord-259669-fod4xkd7 281 27 TLR TLR NNP cord-259669-fod4xkd7 281 28 ligands ligand NNS cord-259669-fod4xkd7 281 29 [ [ -LRB- cord-259669-fod4xkd7 281 30 58 58 CD cord-259669-fod4xkd7 281 31 ] ] -RRB- cord-259669-fod4xkd7 281 32 . . . cord-259669-fod4xkd7 282 1 However however RB cord-259669-fod4xkd7 282 2 , , , cord-259669-fod4xkd7 282 3 the the DT cord-259669-fod4xkd7 282 4 notable notable JJ cord-259669-fod4xkd7 282 5 trait trait NN cord-259669-fod4xkd7 282 6 of of IN cord-259669-fod4xkd7 282 7 pDC pDC NNP cord-259669-fod4xkd7 282 8 is be VBZ cord-259669-fod4xkd7 282 9 their -PRON- PRP$ cord-259669-fod4xkd7 282 10 ability ability NN cord-259669-fod4xkd7 282 11 to to TO cord-259669-fod4xkd7 282 12 produce produce VB cord-259669-fod4xkd7 282 13 INF INF NNP cord-259669-fod4xkd7 282 14 - - , cord-259669-fod4xkd7 282 15 a a NNP cord-259669-fod4xkd7 282 16 Similar Similar NNP cord-259669-fod4xkd7 282 17 to to IN cord-259669-fod4xkd7 282 18 the the DT cord-259669-fod4xkd7 282 19 human human JJ cord-259669-fod4xkd7 282 20 and and CC cord-259669-fod4xkd7 282 21 mouse mouse NN cord-259669-fod4xkd7 282 22 immune immune JJ cord-259669-fod4xkd7 282 23 system system NN cord-259669-fod4xkd7 282 24 , , , cord-259669-fod4xkd7 282 25 porcine porcine JJ cord-259669-fod4xkd7 282 26 pDC pDC NNP cord-259669-fod4xkd7 282 27 are be VBP cord-259669-fod4xkd7 282 28 the the DT cord-259669-fod4xkd7 282 29 most most RBS cord-259669-fod4xkd7 282 30 potent potent JJ cord-259669-fod4xkd7 282 31 producers producer NNS cord-259669-fod4xkd7 282 32 of of IN cord-259669-fod4xkd7 282 33 INF INF NNP cord-259669-fod4xkd7 282 34 - - , cord-259669-fod4xkd7 282 35 a a NN cord-259669-fod4xkd7 282 36 after after IN cord-259669-fod4xkd7 282 37 stimulation stimulation NN cord-259669-fod4xkd7 282 38 with with IN cord-259669-fod4xkd7 282 39 certain certain JJ cord-259669-fod4xkd7 282 40 PAMPs pamp NNS cord-259669-fod4xkd7 282 41 . . . cord-259669-fod4xkd7 283 1 These these DT cord-259669-fod4xkd7 283 2 PAMPs pamp NNS cord-259669-fod4xkd7 283 3 are be VBP cord-259669-fod4xkd7 283 4 the the DT cord-259669-fod4xkd7 283 5 CpG CpG NNP cord-259669-fod4xkd7 283 6 type type NN cord-259669-fod4xkd7 283 7 A a DT cord-259669-fod4xkd7 283 8 motifs motifs NN cord-259669-fod4xkd7 283 9 [ [ -LRB- cord-259669-fod4xkd7 283 10 58 58 CD cord-259669-fod4xkd7 283 11 ] ] -RRB- cord-259669-fod4xkd7 283 12 and and CC cord-259669-fod4xkd7 283 13 TLR7/8 tlr7/8 NN cord-259669-fod4xkd7 283 14 ligands ligand NNS cord-259669-fod4xkd7 283 15 such such JJ cord-259669-fod4xkd7 283 16 as as IN cord-259669-fod4xkd7 283 17 R837 R837 NNPS cord-259669-fod4xkd7 283 18 [ [ -LRB- cord-259669-fod4xkd7 283 19 89 89 CD cord-259669-fod4xkd7 283 20 ] ] -RRB- cord-259669-fod4xkd7 283 21 . . . cord-259669-fod4xkd7 284 1 Such such JJ cord-259669-fod4xkd7 284 2 characteristics characteristic NNS cord-259669-fod4xkd7 284 3 show show VBP cord-259669-fod4xkd7 284 4 a a DT cord-259669-fod4xkd7 284 5 particularly particularly RB cord-259669-fod4xkd7 284 6 close close JJ cord-259669-fod4xkd7 284 7 relationship relationship NN cord-259669-fod4xkd7 284 8 to to IN cord-259669-fod4xkd7 284 9 the the DT cord-259669-fod4xkd7 284 10 human human JJ cord-259669-fod4xkd7 284 11 DC DC NNP cord-259669-fod4xkd7 284 12 system system NN cord-259669-fod4xkd7 284 13 [ [ -LRB- cord-259669-fod4xkd7 284 14 13 13 CD cord-259669-fod4xkd7 284 15 ] ] -RRB- cord-259669-fod4xkd7 284 16 ; ; : cord-259669-fod4xkd7 284 17 pDC pDC NNP cord-259669-fod4xkd7 284 18 respond respond VB cord-259669-fod4xkd7 284 19 to to IN cord-259669-fod4xkd7 284 20 TLR7 TLR7 NNP cord-259669-fod4xkd7 284 21 and and CC cord-259669-fod4xkd7 284 22 9 9 CD cord-259669-fod4xkd7 284 23 ligands ligand NNS cord-259669-fod4xkd7 284 24 , , , cord-259669-fod4xkd7 284 25 whereas whereas IN cord-259669-fod4xkd7 284 26 cDC cDC NNP cord-259669-fod4xkd7 284 27 such such JJ cord-259669-fod4xkd7 284 28 as as IN cord-259669-fod4xkd7 284 29 MoDC MoDC NNP cord-259669-fod4xkd7 284 30 tend tend VB cord-259669-fod4xkd7 284 31 to to TO cord-259669-fod4xkd7 284 32 recognize recognize VB cord-259669-fod4xkd7 284 33 more more JJR cord-259669-fod4xkd7 284 34 TLR2 TLR2 NNP cord-259669-fod4xkd7 284 35 - - HYPH cord-259669-fod4xkd7 284 36 4 4 CD cord-259669-fod4xkd7 284 37 ligands ligand NNS cord-259669-fod4xkd7 284 38 . . . cord-259669-fod4xkd7 285 1 In in IN cord-259669-fod4xkd7 285 2 contrast contrast NN cord-259669-fod4xkd7 285 3 , , , cord-259669-fod4xkd7 285 4 murine murine JJ cord-259669-fod4xkd7 285 5 DC DC NNP cord-259669-fod4xkd7 285 6 and and CC cord-259669-fod4xkd7 285 7 macrophages macrophage NNS cord-259669-fod4xkd7 285 8 also also RB cord-259669-fod4xkd7 285 9 respond respond VBP cord-259669-fod4xkd7 285 10 well well RB cord-259669-fod4xkd7 285 11 to to IN cord-259669-fod4xkd7 285 12 TLR9 tlr9 JJ cord-259669-fod4xkd7 285 13 ligands ligand NNS cord-259669-fod4xkd7 285 14 , , , cord-259669-fod4xkd7 285 15 although although IN cord-259669-fod4xkd7 285 16 it -PRON- PRP cord-259669-fod4xkd7 285 17 is be VBZ cord-259669-fod4xkd7 285 18 again again RB cord-259669-fod4xkd7 285 19 the the DT cord-259669-fod4xkd7 285 20 pDC pdc NN cord-259669-fod4xkd7 285 21 which which WDT cord-259669-fod4xkd7 285 22 produce produce VBP cord-259669-fod4xkd7 285 23 large large JJ cord-259669-fod4xkd7 285 24 quantities quantity NNS cord-259669-fod4xkd7 285 25 of of IN cord-259669-fod4xkd7 285 26 IFN- IFN- NNP cord-259669-fod4xkd7 285 27 ( ( -LRB- cord-259669-fod4xkd7 285 28 [ [ -LRB- cord-259669-fod4xkd7 285 29 13 13 CD cord-259669-fod4xkd7 285 30 ] ] -RRB- cord-259669-fod4xkd7 285 31 . . . cord-259669-fod4xkd7 286 1 Dependent dependent JJ cord-259669-fod4xkd7 286 2 on on IN cord-259669-fod4xkd7 286 3 the the DT cord-259669-fod4xkd7 286 4 stimulus stimulus NN cord-259669-fod4xkd7 286 5 , , , cord-259669-fod4xkd7 286 6 porcine porcine JJ cord-259669-fod4xkd7 286 7 pDC pDC NNP cord-259669-fod4xkd7 286 8 also also RB cord-259669-fod4xkd7 286 9 produce produce VBP cord-259669-fod4xkd7 286 10 large large JJ cord-259669-fod4xkd7 286 11 quantities quantity NNS cord-259669-fod4xkd7 286 12 of of IN cord-259669-fod4xkd7 286 13 TNF TNF NNP cord-259669-fod4xkd7 286 14 - - HYPH cord-259669-fod4xkd7 286 15 a a NNP cord-259669-fod4xkd7 286 16 , , , cord-259669-fod4xkd7 286 17 IL-6 IL-6 NNP cord-259669-fod4xkd7 286 18 and and CC cord-259669-fod4xkd7 286 19 as as IN cord-259669-fod4xkd7 286 20 mentioned mention VBN cord-259669-fod4xkd7 286 21 above above IN cord-259669-fod4xkd7 286 22 IL-12 IL-12 NNP cord-259669-fod4xkd7 286 23 [ [ -LRB- cord-259669-fod4xkd7 286 24 58 58 CD cord-259669-fod4xkd7 286 25 , , , cord-259669-fod4xkd7 286 26 89 89 CD cord-259669-fod4xkd7 286 27 ] ] -RRB- cord-259669-fod4xkd7 286 28 . . . cord-259669-fod4xkd7 287 1 It -PRON- PRP cord-259669-fod4xkd7 287 2 is be VBZ cord-259669-fod4xkd7 287 3 this this DT cord-259669-fod4xkd7 287 4 IL-12 IL-12 NNP cord-259669-fod4xkd7 287 5 induction induction NN cord-259669-fod4xkd7 287 6 , , , cord-259669-fod4xkd7 287 7 which which WDT cord-259669-fod4xkd7 287 8 distinguishes distinguish VBZ cord-259669-fod4xkd7 287 9 porcine porcine JJ cord-259669-fod4xkd7 287 10 pDC pdc NN cord-259669-fod4xkd7 287 11 from from IN cord-259669-fod4xkd7 287 12 their -PRON- PRP$ cord-259669-fod4xkd7 287 13 human human JJ cord-259669-fod4xkd7 287 14 counterparts counterpart NNS cord-259669-fod4xkd7 287 15 [ [ -LRB- cord-259669-fod4xkd7 287 16 13 13 CD cord-259669-fod4xkd7 287 17 ] ] -RRB- cord-259669-fod4xkd7 287 18 . . . cord-259669-fod4xkd7 288 1 The the DT cord-259669-fod4xkd7 288 2 DC DC NNP cord-259669-fod4xkd7 288 3 family family NN cord-259669-fod4xkd7 288 4 is be VBZ cord-259669-fod4xkd7 288 5 particularly particularly RB cord-259669-fod4xkd7 288 6 effective effective JJ cord-259669-fod4xkd7 288 7 at at IN cord-259669-fod4xkd7 288 8 sensing sense VBG cord-259669-fod4xkd7 288 9 viruses virus NNS cord-259669-fod4xkd7 288 10 through through IN cord-259669-fod4xkd7 288 11 cytosolic cytosolic JJ cord-259669-fod4xkd7 288 12 and and CC cord-259669-fod4xkd7 288 13 endosomal endosomal JJ cord-259669-fod4xkd7 288 14 PRR PRR NNP cord-259669-fod4xkd7 288 15 , , , cord-259669-fod4xkd7 288 16 which which WDT cord-259669-fod4xkd7 288 17 detect detect VBP cord-259669-fod4xkd7 288 18 viral viral JJ cord-259669-fod4xkd7 288 19 nucleic nucleic JJ cord-259669-fod4xkd7 288 20 acid acid NN cord-259669-fod4xkd7 288 21 . . . cord-259669-fod4xkd7 289 1 Important important JJ cord-259669-fod4xkd7 289 2 cytosolic cytosolic JJ cord-259669-fod4xkd7 289 3 receptors receptor NNS cord-259669-fod4xkd7 289 4 include include VBP cord-259669-fod4xkd7 289 5 the the DT cord-259669-fod4xkd7 289 6 dsRNA dsrna JJ cord-259669-fod4xkd7 289 7 - - HYPH cord-259669-fod4xkd7 289 8 dependent dependent JJ cord-259669-fod4xkd7 289 9 protein protein NN cord-259669-fod4xkd7 289 10 kinase kinase NN cord-259669-fod4xkd7 289 11 R r NN cord-259669-fod4xkd7 289 12 ( ( -LRB- cord-259669-fod4xkd7 289 13 PKR PKR NNP cord-259669-fod4xkd7 289 14 ) ) -RRB- cord-259669-fod4xkd7 289 15 and and CC cord-259669-fod4xkd7 289 16 the the DT cord-259669-fod4xkd7 289 17 RLR RLR NNP cord-259669-fod4xkd7 289 18 's 's POS cord-259669-fod4xkd7 289 19 RIG rig NN cord-259669-fod4xkd7 289 20 - - : cord-259669-fod4xkd7 289 21 I -PRON- PRP cord-259669-fod4xkd7 289 22 and and CC cord-259669-fod4xkd7 289 23 MDA-5 MDA-5 NNP cord-259669-fod4xkd7 289 24 [ [ -LRB- cord-259669-fod4xkd7 289 25 90 90 CD cord-259669-fod4xkd7 289 26 ] ] -RRB- cord-259669-fod4xkd7 289 27 . . . cord-259669-fod4xkd7 290 1 Generally generally RB cord-259669-fod4xkd7 290 2 , , , cord-259669-fod4xkd7 290 3 such such JJ cord-259669-fod4xkd7 290 4 receptors receptor NNS cord-259669-fod4xkd7 290 5 recognize recognize VBP cord-259669-fod4xkd7 290 6 viral viral JJ cord-259669-fod4xkd7 290 7 replication replication NN cord-259669-fod4xkd7 290 8 occurring occur VBG cord-259669-fod4xkd7 290 9 in in IN cord-259669-fod4xkd7 290 10 situ situ NN cord-259669-fod4xkd7 290 11 - - HYPH cord-259669-fod4xkd7 290 12 being be VBG cord-259669-fod4xkd7 290 13 cytosolic cytosolic JJ cord-259669-fod4xkd7 290 14 , , , cord-259669-fod4xkd7 290 15 these these DT cord-259669-fod4xkd7 290 16 PRR PRR NNP cord-259669-fod4xkd7 290 17 will will MD cord-259669-fod4xkd7 290 18 detect detect VB cord-259669-fod4xkd7 290 19 the the DT cord-259669-fod4xkd7 290 20 intermediates intermediate NNS cord-259669-fod4xkd7 290 21 , , , cord-259669-fod4xkd7 290 22 which which WDT cord-259669-fod4xkd7 290 23 are be VBP cord-259669-fod4xkd7 290 24 also also RB cord-259669-fod4xkd7 290 25 usually usually RB cord-259669-fod4xkd7 290 26 cytosolic cytosolic JJ cord-259669-fod4xkd7 290 27 . . . cord-259669-fod4xkd7 291 1 While while IN cord-259669-fod4xkd7 291 2 RIG rig NN cord-259669-fod4xkd7 291 3 - - : cord-259669-fod4xkd7 291 4 I -PRON- PRP cord-259669-fod4xkd7 291 5 can can MD cord-259669-fod4xkd7 291 6 sense sense VB cord-259669-fod4xkd7 291 7 5 5 CD cord-259669-fod4xkd7 291 8 0triphosphorylated 0triphosphorylated CD cord-259669-fod4xkd7 291 9 singlestranded singlestranded NNP cord-259669-fod4xkd7 291 10 RNA RNA NNP cord-259669-fod4xkd7 291 11 , , , cord-259669-fod4xkd7 291 12 MDA-5 MDA-5 NNP cord-259669-fod4xkd7 291 13 appears appear VBZ cord-259669-fod4xkd7 291 14 to to TO cord-259669-fod4xkd7 291 15 be be VB cord-259669-fod4xkd7 291 16 more more RBR cord-259669-fod4xkd7 291 17 specific specific JJ cord-259669-fod4xkd7 291 18 for for IN cord-259669-fod4xkd7 291 19 dsRNA dsrna NN cord-259669-fod4xkd7 291 20 , , , cord-259669-fod4xkd7 291 21 but but CC cord-259669-fod4xkd7 291 22 the the DT cord-259669-fod4xkd7 291 23 fine fine JJ cord-259669-fod4xkd7 291 24 specifity specifity NN cord-259669-fod4xkd7 291 25 within within IN cord-259669-fod4xkd7 291 26 the the DT cord-259669-fod4xkd7 291 27 helicase helicase NN cord-259669-fod4xkd7 291 28 system system NN cord-259669-fod4xkd7 291 29 is be VBZ cord-259669-fod4xkd7 291 30 not not RB cord-259669-fod4xkd7 291 31 entirely entirely RB cord-259669-fod4xkd7 291 32 clear clear JJ cord-259669-fod4xkd7 291 33 [ [ -LRB- cord-259669-fod4xkd7 291 34 91 91 CD cord-259669-fod4xkd7 291 35 ] ] -RRB- cord-259669-fod4xkd7 291 36 . . . cord-259669-fod4xkd7 292 1 Although although IN cord-259669-fod4xkd7 292 2 these these DT cord-259669-fod4xkd7 292 3 receptors receptor NNS cord-259669-fod4xkd7 292 4 are be VBP cord-259669-fod4xkd7 292 5 ubiquitously ubiquitously RB cord-259669-fod4xkd7 292 6 expressed express VBN cord-259669-fod4xkd7 292 7 , , , cord-259669-fod4xkd7 292 8 their -PRON- PRP$ cord-259669-fod4xkd7 292 9 important important JJ cord-259669-fod4xkd7 292 10 role role NN cord-259669-fod4xkd7 292 11 in in IN cord-259669-fod4xkd7 292 12 the the DT cord-259669-fod4xkd7 292 13 interaction interaction NN cord-259669-fod4xkd7 292 14 of of IN cord-259669-fod4xkd7 292 15 cDC cDC NNS cord-259669-fod4xkd7 292 16 with with IN cord-259669-fod4xkd7 292 17 viruses virus NNS cord-259669-fod4xkd7 292 18 has have VBZ cord-259669-fod4xkd7 292 19 been be VBN cord-259669-fod4xkd7 292 20 demonstrated demonstrate VBN cord-259669-fod4xkd7 292 21 [ [ -LRB- cord-259669-fod4xkd7 292 22 92 92 CD cord-259669-fod4xkd7 292 23 ] ] -RRB- cord-259669-fod4xkd7 292 24 . . . cord-259669-fod4xkd7 293 1 This this DT cord-259669-fod4xkd7 293 2 is be VBZ cord-259669-fod4xkd7 293 3 different different JJ cord-259669-fod4xkd7 293 4 with with IN cord-259669-fod4xkd7 293 5 the the DT cord-259669-fod4xkd7 293 6 endosomal endosomal JJ cord-259669-fod4xkd7 293 7 PRR PRR NNP cord-259669-fod4xkd7 293 8 , , , cord-259669-fod4xkd7 293 9 all all DT cord-259669-fod4xkd7 293 10 members member NNS cord-259669-fod4xkd7 293 11 of of IN cord-259669-fod4xkd7 293 12 the the DT cord-259669-fod4xkd7 293 13 TLR TLR NNP cord-259669-fod4xkd7 293 14 family family NN cord-259669-fod4xkd7 293 15 including include VBG cord-259669-fod4xkd7 293 16 TLR3 TLR3 NNP cord-259669-fod4xkd7 293 17 , , , cord-259669-fod4xkd7 293 18 7 7 CD cord-259669-fod4xkd7 293 19 , , , cord-259669-fod4xkd7 293 20 8 8 CD cord-259669-fod4xkd7 293 21 and and CC cord-259669-fod4xkd7 293 22 9 9 CD cord-259669-fod4xkd7 293 23 , , , cord-259669-fod4xkd7 293 24 which which WDT cord-259669-fod4xkd7 293 25 are be VBP cord-259669-fod4xkd7 293 26 expressed express VBN cord-259669-fod4xkd7 293 27 only only RB cord-259669-fod4xkd7 293 28 on on IN cord-259669-fod4xkd7 293 29 cells cell NNS cord-259669-fod4xkd7 293 30 playing play VBG cord-259669-fod4xkd7 293 31 a a DT cord-259669-fod4xkd7 293 32 specialized specialized JJ cord-259669-fod4xkd7 293 33 role role NN cord-259669-fod4xkd7 293 34 in in IN cord-259669-fod4xkd7 293 35 innate innate JJ cord-259669-fod4xkd7 293 36 immune immune JJ cord-259669-fod4xkd7 293 37 responses response NNS cord-259669-fod4xkd7 293 38 such such JJ cord-259669-fod4xkd7 293 39 as as IN cord-259669-fod4xkd7 293 40 DC DC NNP cord-259669-fod4xkd7 293 41 . . . cord-259669-fod4xkd7 294 1 TLR3 TLR3 NNP cord-259669-fod4xkd7 294 2 represents represent VBZ cord-259669-fod4xkd7 294 3 a a DT cord-259669-fod4xkd7 294 4 receptor receptor NN cord-259669-fod4xkd7 294 5 for for IN cord-259669-fod4xkd7 294 6 dsRNA dsrna NN cord-259669-fod4xkd7 294 7 , , , cord-259669-fod4xkd7 294 8 TLR7 TLR7 NNP cord-259669-fod4xkd7 294 9 and and CC cord-259669-fod4xkd7 294 10 8 8 CD cord-259669-fod4xkd7 294 11 for for IN cord-259669-fod4xkd7 294 12 single single RB cord-259669-fod4xkd7 294 13 - - HYPH cord-259669-fod4xkd7 294 14 stranded strand VBN cord-259669-fod4xkd7 294 15 RNA RNA NNP cord-259669-fod4xkd7 294 16 and and CC cord-259669-fod4xkd7 294 17 TLR9 TLR9 NNP cord-259669-fod4xkd7 294 18 for for IN cord-259669-fod4xkd7 294 19 CpGmotif CpGmotif NNP cord-259669-fod4xkd7 294 20 containing contain VBG cord-259669-fod4xkd7 294 21 DNA dna NN cord-259669-fod4xkd7 294 22 . . . cord-259669-fod4xkd7 295 1 TLR3 TLR3 NNP cord-259669-fod4xkd7 295 2 will will MD cord-259669-fod4xkd7 295 3 not not RB cord-259669-fod4xkd7 295 4 only only RB cord-259669-fod4xkd7 295 5 sense sense VB cord-259669-fod4xkd7 295 6 viruses virus NNS cord-259669-fod4xkd7 295 7 with with IN cord-259669-fod4xkd7 295 8 dsRNA dsrna NN cord-259669-fod4xkd7 295 9 genomes genome NNS cord-259669-fod4xkd7 295 10 but but CC cord-259669-fod4xkd7 295 11 also also RB cord-259669-fod4xkd7 295 12 endocytosed endocytose VBD cord-259669-fod4xkd7 295 13 dsRNA dsrna JJ cord-259669-fod4xkd7 295 14 replicative replicative JJ cord-259669-fod4xkd7 295 15 intermediates intermediate NNS cord-259669-fod4xkd7 295 16 produced produce VBN cord-259669-fod4xkd7 295 17 during during IN cord-259669-fod4xkd7 295 18 the the DT cord-259669-fod4xkd7 295 19 replicative replicative JJ cord-259669-fod4xkd7 295 20 cycle cycle NN cord-259669-fod4xkd7 295 21 of of IN cord-259669-fod4xkd7 295 22 singlestranded singlestranded NNP cord-259669-fod4xkd7 295 23 RNA RNA NNP cord-259669-fod4xkd7 295 24 viruses virus NNS cord-259669-fod4xkd7 295 25 , , , cord-259669-fod4xkd7 295 26 released release VBN cord-259669-fod4xkd7 295 27 from from IN cord-259669-fod4xkd7 295 28 dying die VBG cord-259669-fod4xkd7 295 29 cells cell NNS cord-259669-fod4xkd7 295 30 in in IN cord-259669-fod4xkd7 295 31 the the DT cord-259669-fod4xkd7 295 32 vicinity vicinity NN cord-259669-fod4xkd7 295 33 . . . cord-259669-fod4xkd7 296 1 As as IN cord-259669-fod4xkd7 296 2 summarized summarize VBN cord-259669-fod4xkd7 296 3 in in IN cord-259669-fod4xkd7 296 4 Table Table NNP cord-259669-fod4xkd7 296 5 4 4 CD cord-259669-fod4xkd7 296 6 , , , cord-259669-fod4xkd7 296 7 the the DT cord-259669-fod4xkd7 296 8 studies study NNS cord-259669-fod4xkd7 296 9 with with IN cord-259669-fod4xkd7 296 10 porcine porcine JJ cord-259669-fod4xkd7 296 11 cDC cDC NNS cord-259669-fod4xkd7 296 12 and and CC cord-259669-fod4xkd7 296 13 pDC pDC NNP cord-259669-fod4xkd7 296 14 demonstrate demonstrate VB cord-259669-fod4xkd7 296 15 that that IN cord-259669-fod4xkd7 296 16 similar similar JJ cord-259669-fod4xkd7 296 17 to to IN cord-259669-fod4xkd7 296 18 human human JJ cord-259669-fod4xkd7 296 19 and and CC cord-259669-fod4xkd7 296 20 mouse mouse NN cord-259669-fod4xkd7 296 21 , , , cord-259669-fod4xkd7 296 22 pDC pDC NNP cord-259669-fod4xkd7 296 23 produce produce VBP cord-259669-fod4xkd7 296 24 high high JJ cord-259669-fod4xkd7 296 25 levels level NNS cord-259669-fod4xkd7 296 26 of of IN cord-259669-fod4xkd7 296 27 IFN IFN NNP cord-259669-fod4xkd7 296 28 type type NN cord-259669-fod4xkd7 296 29 I -PRON- PRP cord-259669-fod4xkd7 296 30 to to IN cord-259669-fod4xkd7 296 31 most most JJS cord-259669-fod4xkd7 296 32 viruses virus NNS cord-259669-fod4xkd7 296 33 studied study VBD cord-259669-fod4xkd7 296 34 including include VBG cord-259669-fod4xkd7 296 35 classical classical JJ cord-259669-fod4xkd7 296 36 swine swine NN cord-259669-fod4xkd7 296 37 fever fever NN cord-259669-fod4xkd7 296 38 virus virus NN cord-259669-fod4xkd7 296 39 , , , cord-259669-fod4xkd7 296 40 FMDV FMDV NNP cord-259669-fod4xkd7 296 41 , , , cord-259669-fod4xkd7 296 42 influenza influenza NN cord-259669-fod4xkd7 296 43 virus virus NN cord-259669-fod4xkd7 296 44 , , , cord-259669-fod4xkd7 296 45 lentiviral lentiviral JJ cord-259669-fod4xkd7 296 46 vectors vector NNS cord-259669-fod4xkd7 296 47 ( ( -LRB- cord-259669-fod4xkd7 296 48 LV LV NNP cord-259669-fod4xkd7 296 49 ) ) -RRB- cord-259669-fod4xkd7 296 50 , , , cord-259669-fod4xkd7 296 51 pseudorabies pseudorabies NN cord-259669-fod4xkd7 296 52 virus virus NN cord-259669-fod4xkd7 296 53 ( ( -LRB- cord-259669-fod4xkd7 296 54 PRV PRV NNP cord-259669-fod4xkd7 296 55 ) ) -RRB- cord-259669-fod4xkd7 296 56 and and CC cord-259669-fod4xkd7 296 57 TGEV TGEV NNP cord-259669-fod4xkd7 296 58 , , , cord-259669-fod4xkd7 296 59 while while IN cord-259669-fod4xkd7 296 60 such such JJ cord-259669-fod4xkd7 296 61 responses response NNS cord-259669-fod4xkd7 296 62 are be VBP cord-259669-fod4xkd7 296 63 absent absent JJ cord-259669-fod4xkd7 296 64 or or CC cord-259669-fod4xkd7 296 65 weak weak JJ cord-259669-fod4xkd7 296 66 with with IN cord-259669-fod4xkd7 296 67 cDC cDC NNS cord-259669-fod4xkd7 296 68 . . . cord-259669-fod4xkd7 297 1 The the DT cord-259669-fod4xkd7 297 2 only only JJ cord-259669-fod4xkd7 297 3 exceptions exception NNS cord-259669-fod4xkd7 297 4 described describe VBN cord-259669-fod4xkd7 297 5 to to IN cord-259669-fod4xkd7 297 6 date date NN cord-259669-fod4xkd7 297 7 are be VBP cord-259669-fod4xkd7 297 8 the the DT cord-259669-fod4xkd7 297 9 porcine porcine JJ cord-259669-fod4xkd7 297 10 circovirus circovirus NNP cord-259669-fod4xkd7 297 11 2 2 CD cord-259669-fod4xkd7 297 12 , , , cord-259669-fod4xkd7 297 13 which which WDT cord-259669-fod4xkd7 297 14 can can MD cord-259669-fod4xkd7 297 15 suppress suppress VB cord-259669-fod4xkd7 297 16 IFN IFN NNP cord-259669-fod4xkd7 297 17 response response NN cord-259669-fod4xkd7 297 18 in in IN cord-259669-fod4xkd7 297 19 pDC pDC NNP cord-259669-fod4xkd7 297 20 [ [ -LRB- cord-259669-fod4xkd7 297 21 93 93 CD cord-259669-fod4xkd7 297 22 ] ] -RRB- cord-259669-fod4xkd7 297 23 , , , cord-259669-fod4xkd7 297 24 and and CC cord-259669-fod4xkd7 297 25 Sendai Sendai NNP cord-259669-fod4xkd7 297 26 virus virus NN cord-259669-fod4xkd7 297 27 which which WDT cord-259669-fod4xkd7 297 28 is be VBZ cord-259669-fod4xkd7 297 29 a a DT cord-259669-fod4xkd7 297 30 potent potent JJ cord-259669-fod4xkd7 297 31 inducer inducer NN cord-259669-fod4xkd7 297 32 of of IN cord-259669-fod4xkd7 297 33 IFN IFN NNP cord-259669-fod4xkd7 297 34 type type NN cord-259669-fod4xkd7 297 35 I -PRON- PRP cord-259669-fod4xkd7 297 36 in in IN cord-259669-fod4xkd7 297 37 cDC cDC NNP cord-259669-fod4xkd7 297 38 [ [ -LRB- cord-259669-fod4xkd7 297 39 26 26 CD cord-259669-fod4xkd7 297 40 ] ] -RRB- cord-259669-fod4xkd7 297 41 . . . cord-259669-fod4xkd7 298 1 An an DT cord-259669-fod4xkd7 298 2 important important JJ cord-259669-fod4xkd7 298 3 basis basis NN cord-259669-fod4xkd7 298 4 for for IN cord-259669-fod4xkd7 298 5 the the DT cord-259669-fod4xkd7 298 6 responsiveness responsiveness NN cord-259669-fod4xkd7 298 7 of of IN cord-259669-fod4xkd7 298 8 pDC pDC NNP cord-259669-fod4xkd7 298 9 to to IN cord-259669-fod4xkd7 298 10 viruses virus NNS cord-259669-fod4xkd7 298 11 is be VBZ cord-259669-fod4xkd7 298 12 the the DT cord-259669-fod4xkd7 298 13 expression expression NN cord-259669-fod4xkd7 298 14 of of IN cord-259669-fod4xkd7 298 15 endosomal endosomal NNP cord-259669-fod4xkd7 298 16 TLR7 TLR7 NNP cord-259669-fod4xkd7 298 17 and and CC cord-259669-fod4xkd7 298 18 TLR9 TLR9 NNP cord-259669-fod4xkd7 298 19 , , , cord-259669-fod4xkd7 298 20 which which WDT cord-259669-fod4xkd7 298 21 can can MD cord-259669-fod4xkd7 298 22 be be VB cord-259669-fod4xkd7 298 23 triggered trigger VBN cord-259669-fod4xkd7 298 24 by by IN cord-259669-fod4xkd7 298 25 DNA DNA NNP cord-259669-fod4xkd7 298 26 and and CC cord-259669-fod4xkd7 298 27 RNA RNA NNP cord-259669-fod4xkd7 298 28 viruses virus NNS cord-259669-fod4xkd7 298 29 respectively respectively RB cord-259669-fod4xkd7 298 30 independently independently RB cord-259669-fod4xkd7 298 31 of of IN cord-259669-fod4xkd7 298 32 viral viral JJ cord-259669-fod4xkd7 298 33 replication replication NN cord-259669-fod4xkd7 298 34 [ [ -LRB- cord-259669-fod4xkd7 298 35 94 94 CD cord-259669-fod4xkd7 298 36 ] ] -RRB- cord-259669-fod4xkd7 298 37 . . . cord-259669-fod4xkd7 299 1 In in IN cord-259669-fod4xkd7 299 2 addition addition NN cord-259669-fod4xkd7 299 3 , , , cord-259669-fod4xkd7 299 4 the the DT cord-259669-fod4xkd7 299 5 constitutive constitutive JJ cord-259669-fod4xkd7 299 6 expression expression NN cord-259669-fod4xkd7 299 7 of of IN cord-259669-fod4xkd7 299 8 IRF7 IRF7 NNP cord-259669-fod4xkd7 299 9 , , , cord-259669-fod4xkd7 299 10 the the DT cord-259669-fod4xkd7 299 11 master master NN cord-259669-fod4xkd7 299 12 regulator regulator NN cord-259669-fod4xkd7 299 13 of of IN cord-259669-fod4xkd7 299 14 type type NN cord-259669-fod4xkd7 299 15 I -PRON- PRP cord-259669-fod4xkd7 299 16 IFN IFN NNP cord-259669-fod4xkd7 299 17 , , , cord-259669-fod4xkd7 299 18 represents represent VBZ cord-259669-fod4xkd7 299 19 a a DT cord-259669-fod4xkd7 299 20 unique unique JJ cord-259669-fod4xkd7 299 21 feature feature NN cord-259669-fod4xkd7 299 22 of of IN cord-259669-fod4xkd7 299 23 pDC pDC NNP cord-259669-fod4xkd7 299 24 [ [ -LRB- cord-259669-fod4xkd7 299 25 13 13 CD cord-259669-fod4xkd7 299 26 , , , cord-259669-fod4xkd7 299 27 95 95 CD cord-259669-fod4xkd7 299 28 ] ] -RRB- cord-259669-fod4xkd7 299 29 . . . cord-259669-fod4xkd7 300 1 A a DT cord-259669-fod4xkd7 300 2 good good JJ cord-259669-fod4xkd7 300 3 example example NN cord-259669-fod4xkd7 300 4 showing show VBG cord-259669-fod4xkd7 300 5 the the DT cord-259669-fod4xkd7 300 6 importance importance NN cord-259669-fod4xkd7 300 7 of of IN cord-259669-fod4xkd7 300 8 pDC pDC NNP cord-259669-fod4xkd7 300 9 recognition recognition NN cord-259669-fod4xkd7 300 10 of of IN cord-259669-fod4xkd7 300 11 viruses virus NNS cord-259669-fod4xkd7 300 12 is be VBZ cord-259669-fod4xkd7 300 13 the the DT cord-259669-fod4xkd7 300 14 response response NN cord-259669-fod4xkd7 300 15 seen see VBN cord-259669-fod4xkd7 300 16 with with IN cord-259669-fod4xkd7 300 17 CSFV CSFV NNP cord-259669-fod4xkd7 300 18 . . . cord-259669-fod4xkd7 301 1 This this DT cord-259669-fod4xkd7 301 2 monocytotropic monocytotropic NN cord-259669-fod4xkd7 301 3 , , , cord-259669-fod4xkd7 301 4 haemorrhagic haemorrhagic NNP cord-259669-fod4xkd7 301 5 RNA RNA NNP cord-259669-fod4xkd7 301 6 virus virus NN cord-259669-fod4xkd7 301 7 replicates replicate VBZ cord-259669-fod4xkd7 301 8 efficiently efficiently RB cord-259669-fod4xkd7 301 9 in in IN cord-259669-fod4xkd7 301 10 cDC cDC NNS cord-259669-fod4xkd7 301 11 without without IN cord-259669-fod4xkd7 301 12 apparently apparently RB cord-259669-fod4xkd7 301 13 inducing induce VBG cord-259669-fod4xkd7 301 14 their -PRON- PRP$ cord-259669-fod4xkd7 301 15 activation activation NN cord-259669-fod4xkd7 301 16 or or CC cord-259669-fod4xkd7 301 17 maturation maturation NN cord-259669-fod4xkd7 301 18 [ [ -LRB- cord-259669-fod4xkd7 301 19 87 87 CD cord-259669-fod4xkd7 301 20 ] ] -RRB- cord-259669-fod4xkd7 301 21 . . . cord-259669-fod4xkd7 302 1 The the DT cord-259669-fod4xkd7 302 2 lack lack NN cord-259669-fod4xkd7 302 3 of of IN cord-259669-fod4xkd7 302 4 DC DC NNP cord-259669-fod4xkd7 302 5 activation activation NN cord-259669-fod4xkd7 302 6 is be VBZ cord-259669-fod4xkd7 302 7 not not RB cord-259669-fod4xkd7 302 8 due due JJ cord-259669-fod4xkd7 302 9 to to IN cord-259669-fod4xkd7 302 10 the the DT cord-259669-fod4xkd7 302 11 absence absence NN cord-259669-fod4xkd7 302 12 of of IN cord-259669-fod4xkd7 302 13 a a DT cord-259669-fod4xkd7 302 14 trigger trigger NN cord-259669-fod4xkd7 302 15 , , , cord-259669-fod4xkd7 302 16 because because IN cord-259669-fod4xkd7 302 17 the the DT cord-259669-fod4xkd7 302 18 virus virus NN cord-259669-fod4xkd7 302 19 generates generate VBZ cord-259669-fod4xkd7 302 20 a a DT cord-259669-fod4xkd7 302 21 dsRNA dsrna NN cord-259669-fod4xkd7 302 22 intermediate intermediate JJ cord-259669-fod4xkd7 302 23 in in IN cord-259669-fod4xkd7 302 24 infected infect VBN cord-259669-fod4xkd7 302 25 MoDC modc NN cord-259669-fod4xkd7 302 26 theoretically theoretically RB cord-259669-fod4xkd7 302 27 capable capable JJ cord-259669-fod4xkd7 302 28 of of IN cord-259669-fod4xkd7 302 29 stimulating stimulate VBG cord-259669-fod4xkd7 302 30 RLRs rlr NNS cord-259669-fod4xkd7 302 31 . . . cord-259669-fod4xkd7 303 1 CSFV CSFV NNP cord-259669-fod4xkd7 303 2 actively actively RB cord-259669-fod4xkd7 303 3 prevents prevent VBZ cord-259669-fod4xkd7 303 4 the the DT cord-259669-fod4xkd7 303 5 cDC cdc JJ cord-259669-fod4xkd7 303 6 response response NN cord-259669-fod4xkd7 303 7 to to IN cord-259669-fod4xkd7 303 8 dsRNA dsrna NN cord-259669-fod4xkd7 303 9 through through IN cord-259669-fod4xkd7 303 10 its -PRON- PRP$ cord-259669-fod4xkd7 303 11 non non JJ cord-259669-fod4xkd7 303 12 - - JJ cord-259669-fod4xkd7 303 13 structural structural JJ cord-259669-fod4xkd7 303 14 N n CD cord-259669-fod4xkd7 303 15 pro pro JJ cord-259669-fod4xkd7 303 16 protein protein NN cord-259669-fod4xkd7 303 17 targeting target VBG cord-259669-fod4xkd7 303 18 the the DT cord-259669-fod4xkd7 303 19 IRF-3 IRF-3 NNP cord-259669-fod4xkd7 303 20 pathway pathway NN cord-259669-fod4xkd7 303 21 [ [ -LRB- cord-259669-fod4xkd7 303 22 96 96 CD cord-259669-fod4xkd7 303 23 ] ] -RRB- cord-259669-fod4xkd7 303 24 , , , cord-259669-fod4xkd7 303 25 on on IN cord-259669-fod4xkd7 303 26 which which WDT cord-259669-fod4xkd7 303 27 cDC cDC NNS cord-259669-fod4xkd7 303 28 depend depend VBP cord-259669-fod4xkd7 303 29 for for IN cord-259669-fod4xkd7 303 30 induction induction NN cord-259669-fod4xkd7 303 31 of of IN cord-259669-fod4xkd7 303 32 IFN IFN NNP cord-259669-fod4xkd7 303 33 [ [ -LRB- cord-259669-fod4xkd7 303 34 97 97 CD cord-259669-fod4xkd7 303 35 ] ] -RRB- cord-259669-fod4xkd7 303 36 . . . cord-259669-fod4xkd7 304 1 In in IN cord-259669-fod4xkd7 304 2 contrast contrast NN cord-259669-fod4xkd7 304 3 , , , cord-259669-fod4xkd7 304 4 in in IN cord-259669-fod4xkd7 304 5 pDC pDC NNP cord-259669-fod4xkd7 304 6 CSFV CSFV NNP cord-259669-fod4xkd7 304 7 will will MD cord-259669-fod4xkd7 304 8 induce induce VB cord-259669-fod4xkd7 304 9 IFN- IFN- NNP cord-259669-fod4xkd7 304 10 ( ( -LRB- cord-259669-fod4xkd7 304 11 production production NN cord-259669-fod4xkd7 304 12 [ [ -LRB- cord-259669-fod4xkd7 304 13 57 57 CD cord-259669-fod4xkd7 304 14 ] ] -RRB- cord-259669-fod4xkd7 304 15 . . . cord-259669-fod4xkd7 305 1 As as IN cord-259669-fod4xkd7 305 2 mentioned mention VBN cord-259669-fod4xkd7 305 3 above above RB cord-259669-fod4xkd7 305 4 , , , cord-259669-fod4xkd7 305 5 these these DT cord-259669-fod4xkd7 305 6 cells cell NNS cord-259669-fod4xkd7 305 7 do do VBP cord-259669-fod4xkd7 305 8 not not RB cord-259669-fod4xkd7 305 9 rely rely VB cord-259669-fod4xkd7 305 10 on on IN cord-259669-fod4xkd7 305 11 IRF-3 IRF-3 NNP cord-259669-fod4xkd7 305 12 due due IN cord-259669-fod4xkd7 305 13 to to IN cord-259669-fod4xkd7 305 14 their -PRON- PRP$ cord-259669-fod4xkd7 305 15 high high JJ cord-259669-fod4xkd7 305 16 levels level NNS cord-259669-fod4xkd7 305 17 of of IN cord-259669-fod4xkd7 305 18 constitutive constitutive JJ cord-259669-fod4xkd7 305 19 IRF-7 IRF-7 NNP cord-259669-fod4xkd7 305 20 [ [ -LRB- cord-259669-fod4xkd7 305 21 13 13 CD cord-259669-fod4xkd7 305 22 ] ] -RRB- cord-259669-fod4xkd7 305 23 . . . cord-259669-fod4xkd7 306 1 The the DT cord-259669-fod4xkd7 306 2 production production NN cord-259669-fod4xkd7 306 3 of of IN cord-259669-fod4xkd7 306 4 large large JJ cord-259669-fod4xkd7 306 5 quantities quantity NNS cord-259669-fod4xkd7 306 6 of of IN cord-259669-fod4xkd7 306 7 IFN- IFN- NNP cord-259669-fod4xkd7 306 8 ( ( -LRB- cord-259669-fod4xkd7 306 9 in in IN cord-259669-fod4xkd7 306 10 the the DT cord-259669-fod4xkd7 306 11 serum serum NN cord-259669-fod4xkd7 306 12 of of IN cord-259669-fod4xkd7 306 13 CSFV CSFV NNP cord-259669-fod4xkd7 306 14 - - HYPH cord-259669-fod4xkd7 306 15 infected infect VBN cord-259669-fod4xkd7 306 16 pigs pig NNS cord-259669-fod4xkd7 306 17 [ [ -LRB- cord-259669-fod4xkd7 306 18 98 98 CD cord-259669-fod4xkd7 306 19 , , , cord-259669-fod4xkd7 306 20 99 99 CD cord-259669-fod4xkd7 306 21 ] ] -RRB- cord-259669-fod4xkd7 306 22 presumably presumably RB cord-259669-fod4xkd7 306 23 originating originate VBG cord-259669-fod4xkd7 306 24 from from IN cord-259669-fod4xkd7 306 25 pDC pDC NNP cord-259669-fod4xkd7 306 26 [ [ -LRB- cord-259669-fod4xkd7 306 27 99 99 CD cord-259669-fod4xkd7 306 28 ] ] -RRB- cord-259669-fod4xkd7 306 29 indicates indicate VBZ cord-259669-fod4xkd7 306 30 the the DT cord-259669-fod4xkd7 306 31 importance importance NN cord-259669-fod4xkd7 306 32 of of IN cord-259669-fod4xkd7 306 33 pDC pDC NNP cord-259669-fod4xkd7 306 34 for for IN cord-259669-fod4xkd7 306 35 systemic systemic JJ cord-259669-fod4xkd7 306 36 IFN- IFN- NNP cord-259669-fod4xkd7 306 37 ( ( -LRB- cord-259669-fod4xkd7 306 38 responses response NNS cord-259669-fod4xkd7 306 39 , , , cord-259669-fod4xkd7 306 40 particularly particularly RB cord-259669-fod4xkd7 306 41 when when WRB cord-259669-fod4xkd7 306 42 cDC cdc JJ cord-259669-fod4xkd7 306 43 activities activity NNS cord-259669-fod4xkd7 306 44 are be VBP cord-259669-fod4xkd7 306 45 impaired impair VBN cord-259669-fod4xkd7 306 46 by by IN cord-259669-fod4xkd7 306 47 the the DT cord-259669-fod4xkd7 306 48 pathogen pathogen NN cord-259669-fod4xkd7 306 49 . . . cord-259669-fod4xkd7 307 1 In in IN cord-259669-fod4xkd7 307 2 fact fact NN cord-259669-fod4xkd7 307 3 , , , cord-259669-fod4xkd7 307 4 a a DT cord-259669-fod4xkd7 307 5 number number NN cord-259669-fod4xkd7 307 6 of of IN cord-259669-fod4xkd7 307 7 RNA RNA NNP cord-259669-fod4xkd7 307 8 viruses virus NNS cord-259669-fod4xkd7 307 9 encode encode VBP cord-259669-fod4xkd7 307 10 proteins protein NNS cord-259669-fod4xkd7 307 11 interfering interfere VBG cord-259669-fod4xkd7 307 12 with with IN cord-259669-fod4xkd7 307 13 cellular cellular JJ cord-259669-fod4xkd7 307 14 antiviral antiviral JJ cord-259669-fod4xkd7 307 15 machinery machinery NN cord-259669-fod4xkd7 307 16 and and CC cord-259669-fod4xkd7 307 17 therefore therefore RB cord-259669-fod4xkd7 307 18 prevent prevent VBP cord-259669-fod4xkd7 307 19 activation activation NN cord-259669-fod4xkd7 307 20 of of IN cord-259669-fod4xkd7 307 21 cDC cDC NNP cord-259669-fod4xkd7 307 22 [ [ -LRB- cord-259669-fod4xkd7 307 23 100 100 CD cord-259669-fod4xkd7 307 24 ] ] -RRB- cord-259669-fod4xkd7 307 25 . . . cord-259669-fod4xkd7 308 1 Also also RB cord-259669-fod4xkd7 308 2 with with IN cord-259669-fod4xkd7 308 3 porcine porcine JJ cord-259669-fod4xkd7 308 4 reproductive reproductive JJ cord-259669-fod4xkd7 308 5 and and CC cord-259669-fod4xkd7 308 6 respiratory respiratory JJ cord-259669-fod4xkd7 308 7 syndrome syndrome NN cord-259669-fod4xkd7 308 8 virus virus NN cord-259669-fod4xkd7 308 9 ( ( -LRB- cord-259669-fod4xkd7 308 10 PRRSV PRRSV NNP cord-259669-fod4xkd7 308 11 ) ) -RRB- cord-259669-fod4xkd7 308 12 , , , cord-259669-fod4xkd7 308 13 a a DT cord-259669-fod4xkd7 308 14 productive productive JJ cord-259669-fod4xkd7 308 15 infection infection NN cord-259669-fod4xkd7 308 16 of of IN cord-259669-fod4xkd7 308 17 cDC cDC NNP cord-259669-fod4xkd7 308 18 has have VBZ cord-259669-fod4xkd7 308 19 been be VBN cord-259669-fod4xkd7 308 20 observed observe VBN cord-259669-fod4xkd7 308 21 [ [ -LRB- cord-259669-fod4xkd7 308 22 101 101 CD cord-259669-fod4xkd7 308 23 ] ] -RRB- cord-259669-fod4xkd7 309 1 [ [ -LRB- cord-259669-fod4xkd7 309 2 102 102 CD cord-259669-fod4xkd7 309 3 ] ] -RRB- cord-259669-fod4xkd7 309 4 [ [ -LRB- cord-259669-fod4xkd7 309 5 103 103 CD cord-259669-fod4xkd7 309 6 ] ] -RRB- cord-259669-fod4xkd7 310 1 [ [ -LRB- cord-259669-fod4xkd7 310 2 104 104 CD cord-259669-fod4xkd7 310 3 ] ] -RRB- cord-259669-fod4xkd7 310 4 . . . cord-259669-fod4xkd7 311 1 This this DT cord-259669-fod4xkd7 311 2 apparently apparently RB cord-259669-fod4xkd7 311 3 does do VBZ cord-259669-fod4xkd7 311 4 not not RB cord-259669-fod4xkd7 311 5 result result VB cord-259669-fod4xkd7 311 6 in in IN cord-259669-fod4xkd7 311 7 the the DT cord-259669-fod4xkd7 311 8 secretion secretion NN cord-259669-fod4xkd7 311 9 of of IN cord-259669-fod4xkd7 311 10 type type NN cord-259669-fod4xkd7 311 11 I -PRON- PRP cord-259669-fod4xkd7 311 12 IFN IFN NNP cord-259669-fod4xkd7 311 13 , , , cord-259669-fod4xkd7 311 14 although although IN cord-259669-fod4xkd7 311 15 IFN IFN NNP cord-259669-fod4xkd7 311 16 mRNA mRNA NNP cord-259669-fod4xkd7 311 17 is be VBZ cord-259669-fod4xkd7 311 18 induced induce VBN cord-259669-fod4xkd7 311 19 , , , cord-259669-fod4xkd7 311 20 indicating indicate VBG cord-259669-fod4xkd7 311 21 a a DT cord-259669-fod4xkd7 311 22 block block NN cord-259669-fod4xkd7 311 23 of of IN cord-259669-fod4xkd7 311 24 the the DT cord-259669-fod4xkd7 311 25 IFN IFN NNP cord-259669-fod4xkd7 311 26 system system NN cord-259669-fod4xkd7 311 27 at at IN cord-259669-fod4xkd7 311 28 the the DT cord-259669-fod4xkd7 311 29 translational translational JJ cord-259669-fod4xkd7 311 30 level level NN cord-259669-fod4xkd7 311 31 [ [ -LRB- cord-259669-fod4xkd7 311 32 104 104 CD cord-259669-fod4xkd7 311 33 ] ] -RRB- cord-259669-fod4xkd7 311 34 . . . cord-259669-fod4xkd7 312 1 Whether whether IN cord-259669-fod4xkd7 312 2 PRRSV PRRSV NNP cord-259669-fod4xkd7 312 3 can can MD cord-259669-fod4xkd7 312 4 activate activate VB cord-259669-fod4xkd7 312 5 pDC pDC NNP cord-259669-fod4xkd7 312 6 has have VBZ cord-259669-fod4xkd7 312 7 not not RB cord-259669-fod4xkd7 312 8 yet yet RB cord-259669-fod4xkd7 312 9 been be VBN cord-259669-fod4xkd7 312 10 described describe VBN cord-259669-fod4xkd7 312 11 . . . cord-259669-fod4xkd7 313 1 In in IN cord-259669-fod4xkd7 313 2 addition addition NN cord-259669-fod4xkd7 313 3 to to IN cord-259669-fod4xkd7 313 4 the the DT cord-259669-fod4xkd7 313 5 TLR TLR NNP cord-259669-fod4xkd7 313 6 - - HYPH cord-259669-fod4xkd7 313 7 recognition recognition NN cord-259669-fod4xkd7 313 8 of of IN cord-259669-fod4xkd7 313 9 viral viral JJ cord-259669-fod4xkd7 313 10 PAMPs pamp NNS cord-259669-fod4xkd7 313 11 , , , cord-259669-fod4xkd7 313 12 pDC pDC NNP cord-259669-fod4xkd7 313 13 possess possess VBP cord-259669-fod4xkd7 313 14 other other JJ cord-259669-fod4xkd7 313 15 receptors receptor NNS cord-259669-fod4xkd7 313 16 to to TO cord-259669-fod4xkd7 313 17 sense sense VB cord-259669-fod4xkd7 313 18 viruses virus NNS cord-259669-fod4xkd7 313 19 . . . cord-259669-fod4xkd7 314 1 This this DT cord-259669-fod4xkd7 314 2 has have VBZ cord-259669-fod4xkd7 314 3 been be VBN cord-259669-fod4xkd7 314 4 demonstrated demonstrate VBN cord-259669-fod4xkd7 314 5 for for IN cord-259669-fod4xkd7 314 6 TGEV TGEV NNP cord-259669-fod4xkd7 314 7 , , , cord-259669-fod4xkd7 314 8 an an DT cord-259669-fod4xkd7 314 9 RNA rna NN cord-259669-fod4xkd7 314 10 - - HYPH cord-259669-fod4xkd7 314 11 genome genome NN cord-259669-fod4xkd7 314 12 coronavirus coronavirus NN cord-259669-fod4xkd7 314 13 , , , cord-259669-fod4xkd7 314 14 which which WDT cord-259669-fod4xkd7 314 15 can can MD cord-259669-fod4xkd7 314 16 activate activate VB cord-259669-fod4xkd7 314 17 pDC pDC NNP cord-259669-fod4xkd7 314 18 using use VBG cord-259669-fod4xkd7 314 19 a a DT cord-259669-fod4xkd7 314 20 surface surface NN cord-259669-fod4xkd7 314 21 receptor receptor NN cord-259669-fod4xkd7 314 22 interacting interact VBG cord-259669-fod4xkd7 314 23 with with IN cord-259669-fod4xkd7 314 24 the the DT cord-259669-fod4xkd7 314 25 viral viral JJ cord-259669-fod4xkd7 314 26 M m NN cord-259669-fod4xkd7 314 27 glycoprotein glycoprotein NN cord-259669-fod4xkd7 314 28 [ [ -LRB- cord-259669-fod4xkd7 314 29 105 105 CD cord-259669-fod4xkd7 314 30 ] ] -RRB- cord-259669-fod4xkd7 314 31 . . . cord-259669-fod4xkd7 315 1 Use use NN cord-259669-fod4xkd7 315 2 of of IN cord-259669-fod4xkd7 315 3 inactivated inactivate VBN cord-259669-fod4xkd7 315 4 virus virus NN cord-259669-fod4xkd7 315 5 and and CC cord-259669-fod4xkd7 315 6 subunit subunit NN cord-259669-fod4xkd7 315 7 structures structure NNS cord-259669-fod4xkd7 315 8 has have VBZ cord-259669-fod4xkd7 315 9 demonstrated demonstrate VBN cord-259669-fod4xkd7 315 10 that that IN cord-259669-fod4xkd7 315 11 this this DT cord-259669-fod4xkd7 315 12 activation activation NN cord-259669-fod4xkd7 315 13 is be VBZ cord-259669-fod4xkd7 315 14 independent independent JJ cord-259669-fod4xkd7 315 15 of of IN cord-259669-fod4xkd7 315 16 viral viral JJ cord-259669-fod4xkd7 315 17 nucleic nucleic JJ cord-259669-fod4xkd7 315 18 acid acid NN cord-259669-fod4xkd7 315 19 [ [ -LRB- cord-259669-fod4xkd7 315 20 106 106 CD cord-259669-fod4xkd7 315 21 ] ] -RRB- cord-259669-fod4xkd7 315 22 , , , cord-259669-fod4xkd7 315 23 excluding exclude VBG cord-259669-fod4xkd7 315 24 a a DT cord-259669-fod4xkd7 315 25 role role NN cord-259669-fod4xkd7 315 26 for for IN cord-259669-fod4xkd7 315 27 TLR3 TLR3 NNP cord-259669-fod4xkd7 315 28 and and CC cord-259669-fod4xkd7 315 29 TLR7 TLR7 NNP cord-259669-fod4xkd7 315 30 . . . cord-259669-fod4xkd7 316 1 Moreover moreover RB cord-259669-fod4xkd7 316 2 , , , cord-259669-fod4xkd7 316 3 mutation mutation NN cord-259669-fod4xkd7 316 4 of of IN cord-259669-fod4xkd7 316 5 the the DT cord-259669-fod4xkd7 316 6 glycosylation glycosylation NN cord-259669-fod4xkd7 316 7 site site NN cord-259669-fod4xkd7 316 8 in in IN cord-259669-fod4xkd7 316 9 the the DT cord-259669-fod4xkd7 316 10 M M NNP cord-259669-fod4xkd7 316 11 protein protein NN cord-259669-fod4xkd7 316 12 yields yield VBZ cord-259669-fod4xkd7 316 13 a a DT cord-259669-fod4xkd7 316 14 virus virus NN cord-259669-fod4xkd7 316 15 incapable incapable JJ cord-259669-fod4xkd7 316 16 of of IN cord-259669-fod4xkd7 316 17 inducing induce VBG cord-259669-fod4xkd7 316 18 pDC pdc CD cord-259669-fod4xkd7 316 19 , , , cord-259669-fod4xkd7 316 20 but but CC cord-259669-fod4xkd7 316 21 still still RB cord-259669-fod4xkd7 316 22 capable capable JJ cord-259669-fod4xkd7 316 23 of of IN cord-259669-fod4xkd7 316 24 replication replication NN cord-259669-fod4xkd7 316 25 [ [ -LRB- cord-259669-fod4xkd7 316 26 107 107 CD cord-259669-fod4xkd7 316 27 ] ] -RRB- cord-259669-fod4xkd7 316 28 . . . cord-259669-fod4xkd7 317 1 Also also RB cord-259669-fod4xkd7 317 2 studies study NNS cord-259669-fod4xkd7 317 3 in in IN cord-259669-fod4xkd7 317 4 our -PRON- PRP$ cord-259669-fod4xkd7 317 5 own own JJ cord-259669-fod4xkd7 317 6 laboratory laboratory NN cord-259669-fod4xkd7 317 7 support support VBP cord-259669-fod4xkd7 317 8 the the DT cord-259669-fod4xkd7 317 9 conclusion conclusion NN cord-259669-fod4xkd7 317 10 of of IN cord-259669-fod4xkd7 317 11 triggering trigger VBG cord-259669-fod4xkd7 317 12 through through IN cord-259669-fod4xkd7 317 13 a a DT cord-259669-fod4xkd7 317 14 cell cell NN cord-259669-fod4xkd7 317 15 surface surface NN cord-259669-fod4xkd7 317 16 receptor receptor NN cord-259669-fod4xkd7 317 17 - - HYPH cord-259669-fod4xkd7 317 18 inhibitors inhibitor NNS cord-259669-fod4xkd7 317 19 of of IN cord-259669-fod4xkd7 317 20 endosomal endosomal NNP cord-259669-fod4xkd7 317 21 acidification acidification NN cord-259669-fod4xkd7 317 22 such such JJ cord-259669-fod4xkd7 317 23 as as IN cord-259669-fod4xkd7 317 24 chloroquine chloroquine NN cord-259669-fod4xkd7 317 25 and and CC cord-259669-fod4xkd7 317 26 bafilomycin bafilomycin NNS cord-259669-fod4xkd7 317 27 prevent prevent VBP cord-259669-fod4xkd7 317 28 CpG CpG NNP cord-259669-fod4xkd7 317 29 - - HYPH cord-259669-fod4xkd7 317 30 induction induction NN cord-259669-fod4xkd7 317 31 , , , cord-259669-fod4xkd7 317 32 but but CC cord-259669-fod4xkd7 317 33 not not RB cord-259669-fod4xkd7 317 34 TGEV tgev NN cord-259669-fod4xkd7 317 35 - - HYPH cord-259669-fod4xkd7 317 36 induction induction NN cord-259669-fod4xkd7 317 37 of of IN cord-259669-fod4xkd7 317 38 IFNa IFNa NNS cord-259669-fod4xkd7 317 39 production production NN cord-259669-fod4xkd7 317 40 by by IN cord-259669-fod4xkd7 317 41 pDC pDC NNP cord-259669-fod4xkd7 317 42 [ [ -LRB- cord-259669-fod4xkd7 317 43 63 63 CD cord-259669-fod4xkd7 317 44 ] ] -RRB- cord-259669-fod4xkd7 317 45 . . . cord-259669-fod4xkd7 318 1 Similar similar JJ cord-259669-fod4xkd7 318 2 observations observation NNS cord-259669-fod4xkd7 318 3 have have VBP cord-259669-fod4xkd7 318 4 been be VBN cord-259669-fod4xkd7 318 5 made make VBN cord-259669-fod4xkd7 318 6 with with IN cord-259669-fod4xkd7 318 7 other other JJ cord-259669-fod4xkd7 318 8 viral viral JJ cord-259669-fod4xkd7 318 9 proteins protein NNS cord-259669-fod4xkd7 318 10 such such JJ cord-259669-fod4xkd7 318 11 as as IN cord-259669-fod4xkd7 318 12 HIV HIV NNP cord-259669-fod4xkd7 318 13 - - HYPH cord-259669-fod4xkd7 318 14 derived derive VBN cord-259669-fod4xkd7 318 15 gp120 gp120 NNP cord-259669-fod4xkd7 318 16 and and CC cord-259669-fod4xkd7 318 17 human human NN cord-259669-fod4xkd7 318 18 pDC pdc CD cord-259669-fod4xkd7 318 19 [ [ -LRB- cord-259669-fod4xkd7 318 20 108 108 CD cord-259669-fod4xkd7 318 21 ] ] -RRB- cord-259669-fod4xkd7 318 22 . . . cord-259669-fod4xkd7 319 1 Although although IN cord-259669-fod4xkd7 319 2 porcine porcine JJ cord-259669-fod4xkd7 319 3 pDC pDC NNP cord-259669-fod4xkd7 319 4 like like IN cord-259669-fod4xkd7 319 5 human human NNP cord-259669-fod4xkd7 319 6 pDC pDC NNP cord-259669-fod4xkd7 319 7 are be VBP cord-259669-fod4xkd7 319 8 highly highly RB cord-259669-fod4xkd7 319 9 efficient efficient JJ cord-259669-fod4xkd7 319 10 producers producer NNS cord-259669-fod4xkd7 319 11 of of IN cord-259669-fod4xkd7 319 12 IFNa IFNa NNS cord-259669-fod4xkd7 319 13 and and CC cord-259669-fod4xkd7 319 14 effective effective JJ cord-259669-fod4xkd7 319 15 at at IN cord-259669-fod4xkd7 319 16 sensing sense VBG cord-259669-fod4xkd7 319 17 virus virus NN cord-259669-fod4xkd7 319 18 infections infection NNS cord-259669-fod4xkd7 319 19 , , , cord-259669-fod4xkd7 319 20 not not RB cord-259669-fod4xkd7 319 21 all all DT cord-259669-fod4xkd7 319 22 viruses virus NNS cord-259669-fod4xkd7 319 23 will will MD cord-259669-fod4xkd7 319 24 activate activate VB cord-259669-fod4xkd7 319 25 pDC pDC NNP cord-259669-fod4xkd7 319 26 so so RB cord-259669-fod4xkd7 319 27 efficiently efficiently RB cord-259669-fod4xkd7 319 28 . . . cord-259669-fod4xkd7 320 1 Nonenveloped nonenveloped JJ cord-259669-fod4xkd7 320 2 viruses virus NNS cord-259669-fod4xkd7 320 3 such such JJ cord-259669-fod4xkd7 320 4 as as IN cord-259669-fod4xkd7 320 5 FMDV FMDV NNP cord-259669-fod4xkd7 320 6 - - : cord-259669-fod4xkd7 320 7 an an DT cord-259669-fod4xkd7 320 8 RNA RNA NNP cord-259669-fod4xkd7 320 9 virus virus NN cord-259669-fod4xkd7 320 10 of of IN cord-259669-fod4xkd7 320 11 the the DT cord-259669-fod4xkd7 320 12 Picornaviridae Picornaviridae NNP cord-259669-fod4xkd7 320 13 related relate VBN cord-259669-fod4xkd7 320 14 to to IN cord-259669-fod4xkd7 320 15 poliovirus poliovirus NN cord-259669-fod4xkd7 320 16 and and CC cord-259669-fod4xkd7 320 17 rhinoviruses rhinovirus NNS cord-259669-fod4xkd7 320 18 - - , cord-259669-fod4xkd7 320 19 are be VBP cord-259669-fod4xkd7 320 20 less less RBR cord-259669-fod4xkd7 320 21 efficient efficient JJ cord-259669-fod4xkd7 320 22 to to TO cord-259669-fod4xkd7 320 23 activate activate VB cord-259669-fod4xkd7 320 24 pDC pDC NNP cord-259669-fod4xkd7 320 25 . . . cord-259669-fod4xkd7 321 1 It -PRON- PRP cord-259669-fod4xkd7 321 2 should should MD cord-259669-fod4xkd7 321 3 be be VB cord-259669-fod4xkd7 321 4 noted note VBN cord-259669-fod4xkd7 321 5 that that IN cord-259669-fod4xkd7 321 6 these these DT cord-259669-fod4xkd7 321 7 viruses virus NNS cord-259669-fod4xkd7 321 8 either either CC cord-259669-fod4xkd7 321 9 fail fail VBP cord-259669-fod4xkd7 321 10 to to TO cord-259669-fod4xkd7 321 11 replicate replicate VB cord-259669-fod4xkd7 321 12 in in IN cord-259669-fod4xkd7 321 13 DC DC NNP cord-259669-fod4xkd7 321 14 , , , cord-259669-fod4xkd7 321 15 or or CC cord-259669-fod4xkd7 321 16 produce produce VBP cord-259669-fod4xkd7 321 17 only only RB cord-259669-fod4xkd7 321 18 an an DT cord-259669-fod4xkd7 321 19 abortive abortive JJ cord-259669-fod4xkd7 321 20 infection infection NN cord-259669-fod4xkd7 321 21 [ [ -LRB- cord-259669-fod4xkd7 321 22 109 109 CD cord-259669-fod4xkd7 321 23 ] ] -RRB- cord-259669-fod4xkd7 321 24 [ [ -LRB- cord-259669-fod4xkd7 321 25 110 110 CD cord-259669-fod4xkd7 321 26 ] ] -RRB- cord-259669-fod4xkd7 321 27 [ [ -LRB- cord-259669-fod4xkd7 321 28 111 111 CD cord-259669-fod4xkd7 321 29 ] ] -RRB- cord-259669-fod4xkd7 321 30 . . . cord-259669-fod4xkd7 322 1 Nevertheless nevertheless RB cord-259669-fod4xkd7 322 2 , , , cord-259669-fod4xkd7 322 3 pDC pDC NNP cord-259669-fod4xkd7 322 4 can can MD cord-259669-fod4xkd7 322 5 be be VB cord-259669-fod4xkd7 322 6 efficiently efficiently RB cord-259669-fod4xkd7 322 7 activated activate VBN cord-259669-fod4xkd7 322 8 by by IN cord-259669-fod4xkd7 322 9 FMDV FMDV NNP cord-259669-fod4xkd7 322 10 under under IN cord-259669-fod4xkd7 322 11 particular particular JJ cord-259669-fod4xkd7 322 12 conditions condition NNS cord-259669-fod4xkd7 322 13 . . . cord-259669-fod4xkd7 323 1 In in IN cord-259669-fod4xkd7 323 2 the the DT cord-259669-fod4xkd7 323 3 presence presence NN cord-259669-fod4xkd7 323 4 of of IN cord-259669-fod4xkd7 323 5 opsonizing opsonizing NN cord-259669-fod4xkd7 323 6 factors factor NNS cord-259669-fod4xkd7 323 7 such such JJ cord-259669-fod4xkd7 323 8 as as IN cord-259669-fod4xkd7 323 9 virus virus NN cord-259669-fod4xkd7 323 10 - - HYPH cord-259669-fod4xkd7 323 11 specific specific JJ cord-259669-fod4xkd7 323 12 immunoglobulin immunoglobulin NN cord-259669-fod4xkd7 323 13 ( ( -LRB- cord-259669-fod4xkd7 323 14 Ig Ig NNP cord-259669-fod4xkd7 323 15 ) ) -RRB- cord-259669-fod4xkd7 323 16 , , , cord-259669-fod4xkd7 323 17 which which WDT cord-259669-fod4xkd7 323 18 mediate mediate VBP cord-259669-fod4xkd7 323 19 FcgRII FcgRII NNP cord-259669-fod4xkd7 323 20 - - HYPH cord-259669-fod4xkd7 323 21 enhanced enhance VBN cord-259669-fod4xkd7 323 22 uptake uptake NN cord-259669-fod4xkd7 323 23 of of IN cord-259669-fod4xkd7 323 24 virions virion NNS cord-259669-fod4xkd7 323 25 , , , cord-259669-fod4xkd7 323 26 pDC pDC NNP cord-259669-fod4xkd7 323 27 activation activation NN cord-259669-fod4xkd7 323 28 was be VBD cord-259669-fod4xkd7 323 29 observed observe VBN cord-259669-fod4xkd7 323 30 - - : cord-259669-fod4xkd7 323 31 an an DT cord-259669-fod4xkd7 323 32 event event NN cord-259669-fod4xkd7 323 33 dependent dependent JJ cord-259669-fod4xkd7 323 34 on on IN cord-259669-fod4xkd7 323 35 the the DT cord-259669-fod4xkd7 323 36 presence presence NN cord-259669-fod4xkd7 323 37 of of IN cord-259669-fod4xkd7 323 38 intact intact JJ cord-259669-fod4xkd7 323 39 and and CC cord-259669-fod4xkd7 323 40 active active JJ cord-259669-fod4xkd7 323 41 viral viral JJ cord-259669-fod4xkd7 323 42 RNA RNA NNP cord-259669-fod4xkd7 323 43 [ [ -LRB- cord-259669-fod4xkd7 323 44 63 63 CD cord-259669-fod4xkd7 323 45 ] ] -RRB- cord-259669-fod4xkd7 323 46 . . . cord-259669-fod4xkd7 324 1 Such such PDT cord-259669-fod4xkd7 324 2 an an DT cord-259669-fod4xkd7 324 3 activity activity NN cord-259669-fod4xkd7 324 4 would would MD cord-259669-fod4xkd7 324 5 provide provide VB cord-259669-fod4xkd7 324 6 important important JJ cord-259669-fod4xkd7 324 7 antiviral antiviral JJ cord-259669-fod4xkd7 324 8 innate innate JJ cord-259669-fod4xkd7 324 9 defences defence NNS cord-259669-fod4xkd7 324 10 at at IN cord-259669-fod4xkd7 324 11 a a DT cord-259669-fod4xkd7 324 12 time time NN cord-259669-fod4xkd7 324 13 early early JJ cord-259669-fod4xkd7 324 14 post post NN cord-259669-fod4xkd7 324 15 - - NN cord-259669-fod4xkd7 324 16 vaccination vaccination NN cord-259669-fod4xkd7 324 17 when when WRB cord-259669-fod4xkd7 324 18 the the DT cord-259669-fod4xkd7 324 19 adaptive adaptive JJ cord-259669-fod4xkd7 324 20 response response NN cord-259669-fod4xkd7 324 21 had have VBD cord-259669-fod4xkd7 324 22 begun begin VBN cord-259669-fod4xkd7 324 23 producing produce VBG cord-259669-fod4xkd7 324 24 specific specific JJ cord-259669-fod4xkd7 324 25 antibody antibody NN cord-259669-fod4xkd7 324 26 , , , cord-259669-fod4xkd7 324 27 but but CC cord-259669-fod4xkd7 324 28 is be VBZ cord-259669-fod4xkd7 324 29 inadequate inadequate JJ cord-259669-fod4xkd7 324 30 to to TO cord-259669-fod4xkd7 324 31 protect protect VB cord-259669-fod4xkd7 324 32 the the DT cord-259669-fod4xkd7 324 33 host host NN cord-259669-fod4xkd7 324 34 from from IN cord-259669-fod4xkd7 324 35 disease disease NN cord-259669-fod4xkd7 324 36 or or CC cord-259669-fod4xkd7 324 37 virus virus NN cord-259669-fod4xkd7 324 38 replication replication NN cord-259669-fod4xkd7 324 39 . . . cord-259669-fod4xkd7 325 1 This this DT cord-259669-fod4xkd7 325 2 function function NN cord-259669-fod4xkd7 325 3 of of IN cord-259669-fod4xkd7 325 4 pDC pDC NNP cord-259669-fod4xkd7 325 5 would would MD cord-259669-fod4xkd7 325 6 have have VB cord-259669-fod4xkd7 325 7 an an DT cord-259669-fod4xkd7 325 8 additional additional JJ cord-259669-fod4xkd7 325 9 advantageassisting advantageassiste VBG cord-259669-fod4xkd7 325 10 cDC cDC NNS cord-259669-fod4xkd7 325 11 in in IN cord-259669-fod4xkd7 325 12 promoting promote VBG cord-259669-fod4xkd7 325 13 the the DT cord-259669-fod4xkd7 325 14 development development NN cord-259669-fod4xkd7 325 15 of of IN cord-259669-fod4xkd7 325 16 an an DT cord-259669-fod4xkd7 325 17 efficacious efficacious JJ cord-259669-fod4xkd7 325 18 adaptive adaptive JJ cord-259669-fod4xkd7 325 19 immune immune JJ cord-259669-fod4xkd7 325 20 defence defence NN cord-259669-fod4xkd7 325 21 for for IN cord-259669-fod4xkd7 325 22 protecting protect VBG cord-259669-fod4xkd7 325 23 the the DT cord-259669-fod4xkd7 325 24 host host NN cord-259669-fod4xkd7 325 25 . . . cord-259669-fod4xkd7 326 1 FMDV FMDV NNP cord-259669-fod4xkd7 326 2 can can MD cord-259669-fod4xkd7 326 3 also also RB cord-259669-fod4xkd7 326 4 infect infect VB cord-259669-fod4xkd7 326 5 cDC cDC NNS cord-259669-fod4xkd7 326 6 including include VBG cord-259669-fod4xkd7 326 7 skin skin NN cord-259669-fod4xkd7 326 8 DC DC NNP cord-259669-fod4xkd7 326 9 and and CC cord-259669-fod4xkd7 326 10 MoDC MoDC NNP cord-259669-fod4xkd7 326 11 [ [ -LRB- cord-259669-fod4xkd7 326 12 109 109 CD cord-259669-fod4xkd7 326 13 , , , cord-259669-fod4xkd7 326 14 112 112 CD cord-259669-fod4xkd7 326 15 ] ] -RRB- cord-259669-fod4xkd7 326 16 , , , cord-259669-fod4xkd7 326 17 which which WDT cord-259669-fod4xkd7 326 18 results result VBZ cord-259669-fod4xkd7 326 19 in in IN cord-259669-fod4xkd7 326 20 low low JJ cord-259669-fod4xkd7 326 21 levels level NNS cord-259669-fod4xkd7 326 22 if if IN cord-259669-fod4xkd7 326 23 IFN IFN NNP cord-259669-fod4xkd7 326 24 - - HYPH cord-259669-fod4xkd7 326 25 b b NN cord-259669-fod4xkd7 326 26 secretion secretion NN cord-259669-fod4xkd7 326 27 . . . cord-259669-fod4xkd7 327 1 Just just RB cord-259669-fod4xkd7 327 2 as as IN cord-259669-fod4xkd7 327 3 in in FW cord-259669-fod4xkd7 327 4 vitro vitro FW cord-259669-fod4xkd7 327 5 analyses analysis NNS cord-259669-fod4xkd7 327 6 cover cover VBP cord-259669-fod4xkd7 327 7 only only RB cord-259669-fod4xkd7 327 8 a a DT cord-259669-fod4xkd7 327 9 proportion proportion NN cord-259669-fod4xkd7 327 10 of of IN cord-259669-fod4xkd7 327 11 likely likely JJ cord-259669-fod4xkd7 327 12 events event NNS cord-259669-fod4xkd7 327 13 in in IN cord-259669-fod4xkd7 327 14 vivo vivo NN cord-259669-fod4xkd7 327 15 , , , cord-259669-fod4xkd7 327 16 focusing focus VBG cord-259669-fod4xkd7 327 17 on on IN cord-259669-fod4xkd7 327 18 phenotypic phenotypic JJ cord-259669-fod4xkd7 327 19 modulation modulation NN cord-259669-fod4xkd7 327 20 of of IN cord-259669-fod4xkd7 327 21 DC DC NNP cord-259669-fod4xkd7 327 22 and and CC cord-259669-fod4xkd7 327 23 cytokine cytokine NN cord-259669-fod4xkd7 327 24 profiles profile NNS cord-259669-fod4xkd7 327 25 will will MD cord-259669-fod4xkd7 327 26 reveal reveal VB cord-259669-fod4xkd7 327 27 only only JJ cord-259669-fod4xkd7 327 28 part part NN cord-259669-fod4xkd7 327 29 of of IN cord-259669-fod4xkd7 327 30 the the DT cord-259669-fod4xkd7 327 31 story story NN cord-259669-fod4xkd7 327 32 . . . cord-259669-fod4xkd7 328 1 During during IN cord-259669-fod4xkd7 328 2 immune immune JJ cord-259669-fod4xkd7 328 3 defence defence NN cord-259669-fod4xkd7 328 4 development development NN cord-259669-fod4xkd7 328 5 , , , cord-259669-fod4xkd7 328 6 these these DT cord-259669-fod4xkd7 328 7 modulations modulation NNS cord-259669-fod4xkd7 328 8 of of IN cord-259669-fod4xkd7 328 9 the the DT cord-259669-fod4xkd7 328 10 DC DC NNP cord-259669-fod4xkd7 328 11 serve serve VBP cord-259669-fod4xkd7 328 12 a a DT cord-259669-fod4xkd7 328 13 purpose purpose NN cord-259669-fod4xkd7 328 14 beyond beyond IN cord-259669-fod4xkd7 328 15 the the DT cord-259669-fod4xkd7 328 16 direct direct JJ cord-259669-fod4xkd7 328 17 attack attack NN cord-259669-fod4xkd7 328 18 on on IN cord-259669-fod4xkd7 328 19 the the DT cord-259669-fod4xkd7 328 20 pathogen pathogen NN cord-259669-fod4xkd7 328 21 by by IN cord-259669-fod4xkd7 328 22 the the DT cord-259669-fod4xkd7 328 23 DC DC NNP cord-259669-fod4xkd7 328 24 . . . cord-259669-fod4xkd7 329 1 That that DT cord-259669-fod4xkd7 329 2 additional additional JJ cord-259669-fod4xkd7 329 3 purpose purpose NN cord-259669-fod4xkd7 329 4 is be VBZ cord-259669-fod4xkd7 329 5 promoting promote VBG cord-259669-fod4xkd7 329 6 the the DT cord-259669-fod4xkd7 329 7 functional functional JJ cord-259669-fod4xkd7 329 8 interaction interaction NN cord-259669-fod4xkd7 329 9 with with IN cord-259669-fod4xkd7 329 10 the the DT cord-259669-fod4xkd7 329 11 adaptive adaptive JJ cord-259669-fod4xkd7 329 12 immune immune JJ cord-259669-fod4xkd7 329 13 system system NN cord-259669-fod4xkd7 329 14 . . . cord-259669-fod4xkd7 330 1 The the DT cord-259669-fod4xkd7 330 2 interaction interaction NN cord-259669-fod4xkd7 330 3 between between IN cord-259669-fod4xkd7 330 4 T T NNP cord-259669-fod4xkd7 330 5 lymphocytes lymphocyte NNS cord-259669-fod4xkd7 330 6 and and CC cord-259669-fod4xkd7 330 7 DC DC NNP cord-259669-fod4xkd7 330 8 is be VBZ cord-259669-fod4xkd7 330 9 a a DT cord-259669-fod4xkd7 330 10 bilateral bilateral JJ cord-259669-fod4xkd7 330 11 process process NN cord-259669-fod4xkd7 330 12 . . . cord-259669-fod4xkd7 331 1 On on IN cord-259669-fod4xkd7 331 2 one one CD cord-259669-fod4xkd7 331 3 side side NN cord-259669-fod4xkd7 331 4 there there EX cord-259669-fod4xkd7 331 5 is be VBZ cord-259669-fod4xkd7 331 6 the the DT cord-259669-fod4xkd7 331 7 central central JJ cord-259669-fod4xkd7 331 8 role role NN cord-259669-fod4xkd7 331 9 of of IN cord-259669-fod4xkd7 331 10 DC DC NNP cord-259669-fod4xkd7 331 11 in in IN cord-259669-fod4xkd7 331 12 presenting present VBG cord-259669-fod4xkd7 331 13 antigen antigen NN cord-259669-fod4xkd7 331 14 and and CC cord-259669-fod4xkd7 331 15 stimulating stimulate VBG cord-259669-fod4xkd7 331 16 T t NN cord-259669-fod4xkd7 331 17 cells cell NNS cord-259669-fod4xkd7 331 18 . . . cord-259669-fod4xkd7 332 1 This this DT cord-259669-fod4xkd7 332 2 has have VBZ cord-259669-fod4xkd7 332 3 been be VBN cord-259669-fod4xkd7 332 4 shown show VBN cord-259669-fod4xkd7 332 5 in in IN cord-259669-fod4xkd7 332 6 several several JJ cord-259669-fod4xkd7 332 7 models model NNS cord-259669-fod4xkd7 332 8 including include VBG cord-259669-fod4xkd7 332 9 mixed mixed JJ cord-259669-fod4xkd7 332 10 leukocyte leukocyte NN cord-259669-fod4xkd7 332 11 reactions reaction NNS cord-259669-fod4xkd7 332 12 [ [ -LRB- cord-259669-fod4xkd7 332 13 24 24 CD cord-259669-fod4xkd7 332 14 , , , cord-259669-fod4xkd7 332 15 26 26 CD cord-259669-fod4xkd7 332 16 ] ] -RRB- cord-259669-fod4xkd7 332 17 , , , cord-259669-fod4xkd7 332 18 superantigen superantigen NN cord-259669-fod4xkd7 332 19 presentation presentation NN cord-259669-fod4xkd7 332 20 [ [ -LRB- cord-259669-fod4xkd7 332 21 23 23 CD cord-259669-fod4xkd7 332 22 ] ] -RRB- cord-259669-fod4xkd7 332 23 as as RB cord-259669-fod4xkd7 332 24 well well RB cord-259669-fod4xkd7 332 25 as as IN cord-259669-fod4xkd7 332 26 antigen antigen NN cord-259669-fod4xkd7 332 27 specific specific JJ cord-259669-fod4xkd7 332 28 T t NN cord-259669-fod4xkd7 332 29 - - HYPH cord-259669-fod4xkd7 332 30 cell cell NN cord-259669-fod4xkd7 332 31 restimulation restimulation NN cord-259669-fod4xkd7 332 32 [ [ -LRB- cord-259669-fod4xkd7 332 33 25 25 CD cord-259669-fod4xkd7 332 34 , , , cord-259669-fod4xkd7 332 35 75 75 CD cord-259669-fod4xkd7 332 36 , , , cord-259669-fod4xkd7 332 37 87 87 CD cord-259669-fod4xkd7 332 38 , , , cord-259669-fod4xkd7 332 39 113 113 CD cord-259669-fod4xkd7 332 40 , , , cord-259669-fod4xkd7 332 41 114 114 CD cord-259669-fod4xkd7 332 42 ] ] -RRB- cord-259669-fod4xkd7 332 43 ( ( -LRB- cord-259669-fod4xkd7 332 44 see see VB cord-259669-fod4xkd7 332 45 also also RB cord-259669-fod4xkd7 332 46 Table Table NNP cord-259669-fod4xkd7 332 47 3 3 CD cord-259669-fod4xkd7 332 48 ) ) -RRB- cord-259669-fod4xkd7 332 49 . . . cord-259669-fod4xkd7 333 1 On on IN cord-259669-fod4xkd7 333 2 the the DT cord-259669-fod4xkd7 333 3 other other JJ cord-259669-fod4xkd7 333 4 side side NN cord-259669-fod4xkd7 333 5 , , , cord-259669-fod4xkd7 333 6 T t NN cord-259669-fod4xkd7 333 7 lymphocytes lymphocyte NNS cord-259669-fod4xkd7 333 8 provide provide VBP cord-259669-fod4xkd7 333 9 important important JJ cord-259669-fod4xkd7 333 10 signals signal NNS cord-259669-fod4xkd7 333 11 to to IN cord-259669-fod4xkd7 333 12 DC DC NNP cord-259669-fod4xkd7 333 13 . . . cord-259669-fod4xkd7 334 1 With with IN cord-259669-fod4xkd7 334 2 porcine porcine JJ cord-259669-fod4xkd7 334 3 MoDC modc NN cord-259669-fod4xkd7 334 4 cultures culture NNS cord-259669-fod4xkd7 334 5 we -PRON- PRP cord-259669-fod4xkd7 334 6 have have VBP cord-259669-fod4xkd7 334 7 observed observe VBN cord-259669-fod4xkd7 334 8 that that IN cord-259669-fod4xkd7 334 9 after after IN cord-259669-fod4xkd7 334 10 the the DT cord-259669-fod4xkd7 334 11 co co NN cord-259669-fod4xkd7 334 12 - - NN cord-259669-fod4xkd7 334 13 culture culture NN cord-259669-fod4xkd7 334 14 of of IN cord-259669-fod4xkd7 334 15 cytokinematured cytokinematured JJ cord-259669-fod4xkd7 334 16 DC DC NNP cord-259669-fod4xkd7 334 17 with with IN cord-259669-fod4xkd7 334 18 T T NNP cord-259669-fod4xkd7 334 19 cells cell NNS cord-259669-fod4xkd7 334 20 in in IN cord-259669-fod4xkd7 334 21 the the DT cord-259669-fod4xkd7 334 22 presence presence NN cord-259669-fod4xkd7 334 23 of of IN cord-259669-fod4xkd7 334 24 antigens antigen NNS cord-259669-fod4xkd7 334 25 , , , cord-259669-fod4xkd7 334 26 a a DT cord-259669-fod4xkd7 334 27 further further JJ cord-259669-fod4xkd7 334 28 upregulation upregulation NN cord-259669-fod4xkd7 334 29 of of IN cord-259669-fod4xkd7 334 30 MHC MHC NNP cord-259669-fod4xkd7 334 31 class class NN cord-259669-fod4xkd7 334 32 II II NNP cord-259669-fod4xkd7 334 33 expression expression NN cord-259669-fod4xkd7 334 34 was be VBD cord-259669-fod4xkd7 334 35 obtained obtain VBN cord-259669-fod4xkd7 334 36 reaching reach VBG cord-259669-fod4xkd7 334 37 levels level NNS cord-259669-fod4xkd7 334 38 clearly clearly RB cord-259669-fod4xkd7 334 39 above above IN cord-259669-fod4xkd7 334 40 those those DT cord-259669-fod4xkd7 334 41 obtained obtain VBN cord-259669-fod4xkd7 334 42 with with IN cord-259669-fod4xkd7 334 43 any any DT cord-259669-fod4xkd7 334 44 stimuli stimulus NNS cord-259669-fod4xkd7 334 45 in in IN cord-259669-fod4xkd7 334 46 the the DT cord-259669-fod4xkd7 334 47 absence absence NN cord-259669-fod4xkd7 334 48 of of IN cord-259669-fod4xkd7 334 49 Tcells Tcells NNP cord-259669-fod4xkd7 334 50 [ [ -LRB- cord-259669-fod4xkd7 334 51 64 64 CD cord-259669-fod4xkd7 334 52 ] ] -RRB- cord-259669-fod4xkd7 334 53 . . . cord-259669-fod4xkd7 335 1 Interestingly interestingly RB cord-259669-fod4xkd7 335 2 , , , cord-259669-fod4xkd7 335 3 TNF TNF NNP cord-259669-fod4xkd7 335 4 - - : cord-259669-fod4xkd7 335 5 a a DT cord-259669-fod4xkd7 335 6 pre pre JJ cord-259669-fod4xkd7 335 7 - - NN cord-259669-fod4xkd7 335 8 treatment treatment NN cord-259669-fod4xkd7 335 9 of of IN cord-259669-fod4xkd7 335 10 the the DT cord-259669-fod4xkd7 335 11 DC DC NNP cord-259669-fod4xkd7 335 12 was be VBD cord-259669-fod4xkd7 335 13 as as RB cord-259669-fod4xkd7 335 14 efficient efficient JJ cord-259669-fod4xkd7 335 15 as as IN cord-259669-fod4xkd7 335 16 TNF TNF NNP cord-259669-fod4xkd7 335 17 - - : cord-259669-fod4xkd7 335 18 a a NNP cord-259669-fod4xkd7 335 19 / / SYM cord-259669-fod4xkd7 335 20 IFN IFN NNP cord-259669-fod4xkd7 335 21 - - : cord-259669-fod4xkd7 335 22 a a DT cord-259669-fod4xkd7 335 23 cocktails cocktail NNS cord-259669-fod4xkd7 335 24 to to TO cord-259669-fod4xkd7 335 25 sensitize sensitize VB cord-259669-fod4xkd7 335 26 the the DT cord-259669-fod4xkd7 335 27 DC DC NNP cord-259669-fod4xkd7 335 28 for for IN cord-259669-fod4xkd7 335 29 this this DT cord-259669-fod4xkd7 335 30 process process NN cord-259669-fod4xkd7 335 31 . . . cord-259669-fod4xkd7 336 1 These these DT cord-259669-fod4xkd7 336 2 in in IN cord-259669-fod4xkd7 336 3 vitro vitro FW cord-259669-fod4xkd7 336 4 observations observation NNS cord-259669-fod4xkd7 336 5 indicate indicate VBP cord-259669-fod4xkd7 336 6 that that IN cord-259669-fod4xkd7 336 7 MoDC MoDC NNP cord-259669-fod4xkd7 336 8 maturation maturation NN cord-259669-fod4xkd7 336 9 is be VBZ cord-259669-fod4xkd7 336 10 a a DT cord-259669-fod4xkd7 336 11 regulated regulated JJ cord-259669-fod4xkd7 336 12 multistep multistep NN cord-259669-fod4xkd7 336 13 process process NN cord-259669-fod4xkd7 336 14 . . . cord-259669-fod4xkd7 337 1 From from IN cord-259669-fod4xkd7 337 2 a a DT cord-259669-fod4xkd7 337 3 practical practical JJ cord-259669-fod4xkd7 337 4 point point NN cord-259669-fod4xkd7 337 5 of of IN cord-259669-fod4xkd7 337 6 view view NN cord-259669-fod4xkd7 337 7 this this DT cord-259669-fod4xkd7 337 8 means mean VBZ cord-259669-fod4xkd7 337 9 that that IN cord-259669-fod4xkd7 337 10 although although IN cord-259669-fod4xkd7 337 11 TNF TNF NNP cord-259669-fod4xkd7 337 12 - - : cord-259669-fod4xkd7 337 13 a a DT cord-259669-fod4xkd7 337 14 alone alone RB cord-259669-fod4xkd7 337 15 is be VBZ cord-259669-fod4xkd7 337 16 not not RB cord-259669-fod4xkd7 337 17 sufficient sufficient JJ cord-259669-fod4xkd7 337 18 to to TO cord-259669-fod4xkd7 337 19 induce induce VB cord-259669-fod4xkd7 337 20 MoDC modc JJ cord-259669-fod4xkd7 337 21 maturation maturation NN cord-259669-fod4xkd7 337 22 , , , cord-259669-fod4xkd7 337 23 the the DT cord-259669-fod4xkd7 337 24 T t NN cord-259669-fod4xkd7 337 25 - - HYPH cord-259669-fod4xkd7 337 26 cell cell NN cord-259669-fod4xkd7 337 27 responses response NNS cord-259669-fod4xkd7 337 28 induced induce VBN cord-259669-fod4xkd7 337 29 by by IN cord-259669-fod4xkd7 337 30 TNF TNF NNP cord-259669-fod4xkd7 337 31 - - HYPH cord-259669-fod4xkd7 337 32 a a DT cord-259669-fod4xkd7 337 33 - - HYPH cord-259669-fod4xkd7 337 34 treated treat VBN cord-259669-fod4xkd7 337 35 DC DC NNP cord-259669-fod4xkd7 337 36 can can MD cord-259669-fod4xkd7 337 37 compensate compensate VB cord-259669-fod4xkd7 337 38 to to TO cord-259669-fod4xkd7 337 39 provide provide VB cord-259669-fod4xkd7 337 40 stimuli stimulus NNS cord-259669-fod4xkd7 337 41 reaching reach VBG cord-259669-fod4xkd7 337 42 those those DT cord-259669-fod4xkd7 337 43 obtained obtain VBN cord-259669-fod4xkd7 337 44 with with IN cord-259669-fod4xkd7 337 45 more more RBR cord-259669-fod4xkd7 337 46 potent potent JJ cord-259669-fod4xkd7 337 47 maturation maturation NN cord-259669-fod4xkd7 337 48 cocktails cocktail NNS cord-259669-fod4xkd7 337 49 such such JJ cord-259669-fod4xkd7 337 50 as as IN cord-259669-fod4xkd7 337 51 TNF TNF NNP cord-259669-fod4xkd7 337 52 - - : cord-259669-fod4xkd7 337 53 a a DT cord-259669-fod4xkd7 338 1 /IFN /IFN NNP cord-259669-fod4xkd7 338 2 - - : cord-259669-fod4xkd7 338 3 a a NN cord-259669-fod4xkd7 338 4 or or CC cord-259669-fod4xkd7 338 5 TLR TLR NNP cord-259669-fod4xkd7 338 6 ligands ligand NNS cord-259669-fod4xkd7 338 7 [ [ -LRB- cord-259669-fod4xkd7 338 8 64 64 CD cord-259669-fod4xkd7 338 9 ] ] -RRB- cord-259669-fod4xkd7 338 10 . . . cord-259669-fod4xkd7 339 1 Moreover moreover RB cord-259669-fod4xkd7 339 2 , , , cord-259669-fod4xkd7 339 3 the the DT cord-259669-fod4xkd7 339 4 T t NN cord-259669-fod4xkd7 339 5 - - HYPH cord-259669-fod4xkd7 339 6 lymphocyte lymphocyte NN cord-259669-fod4xkd7 339 7 activity activity NN cord-259669-fod4xkd7 339 8 provides provide VBZ cord-259669-fod4xkd7 339 9 an an DT cord-259669-fod4xkd7 339 10 additional additional JJ cord-259669-fod4xkd7 339 11 advantage advantage NN cord-259669-fod4xkd7 339 12 in in IN cord-259669-fod4xkd7 339 13 that that DT cord-259669-fod4xkd7 339 14 cocktails cocktail NNS cord-259669-fod4xkd7 339 15 such such JJ cord-259669-fod4xkd7 339 16 as as IN cord-259669-fod4xkd7 339 17 TNF TNF NNP cord-259669-fod4xkd7 339 18 - - : cord-259669-fod4xkd7 339 19 a a DT cord-259669-fod4xkd7 340 1 /IFN /IFN NNP cord-259669-fod4xkd7 340 2 - - : cord-259669-fod4xkd7 340 3 a a DT cord-259669-fod4xkd7 340 4 , , , cord-259669-fod4xkd7 340 5 as as RB cord-259669-fod4xkd7 340 6 well well RB cord-259669-fod4xkd7 340 7 as as IN cord-259669-fod4xkd7 340 8 those those DT cord-259669-fod4xkd7 340 9 combined combine VBN cord-259669-fod4xkd7 340 10 with with IN cord-259669-fod4xkd7 340 11 TLR TLR NNP cord-259669-fod4xkd7 340 12 can can MD cord-259669-fod4xkd7 340 13 have have VB cord-259669-fod4xkd7 340 14 the the DT cord-259669-fod4xkd7 340 15 drawback drawback NN cord-259669-fod4xkd7 340 16 of of IN cord-259669-fod4xkd7 340 17 ' ' `` cord-259669-fod4xkd7 340 18 ' ' `` cord-259669-fod4xkd7 340 19 exhausting exhaust VBG cord-259669-fod4xkd7 340 20 ' ' '' cord-259669-fod4xkd7 340 21 ' ' '' cord-259669-fod4xkd7 340 22 the the DT cord-259669-fod4xkd7 340 23 DC DC NNP cord-259669-fod4xkd7 340 24 . . . cord-259669-fod4xkd7 341 1 Similar similar JJ cord-259669-fod4xkd7 341 2 to to IN cord-259669-fod4xkd7 341 3 other other JJ cord-259669-fod4xkd7 341 4 species specie NNS cord-259669-fod4xkd7 341 5 , , , cord-259669-fod4xkd7 341 6 it -PRON- PRP cord-259669-fod4xkd7 341 7 has have VBZ cord-259669-fod4xkd7 341 8 been be VBN cord-259669-fod4xkd7 341 9 demonstrated demonstrate VBN cord-259669-fod4xkd7 341 10 that that IN cord-259669-fod4xkd7 341 11 DC DC NNP cord-259669-fod4xkd7 341 12 can can MD cord-259669-fod4xkd7 341 13 modulate modulate VB cord-259669-fod4xkd7 341 14 the the DT cord-259669-fod4xkd7 341 15 type type NN cord-259669-fod4xkd7 341 16 of of IN cord-259669-fod4xkd7 341 17 T t NN cord-259669-fod4xkd7 341 18 - - HYPH cord-259669-fod4xkd7 341 19 cell cell NN cord-259669-fod4xkd7 341 20 response response NN cord-259669-fod4xkd7 341 21 induced induce VBN cord-259669-fod4xkd7 341 22 . . . cord-259669-fod4xkd7 342 1 For for IN cord-259669-fod4xkd7 342 2 example example NN cord-259669-fod4xkd7 342 3 , , , cord-259669-fod4xkd7 342 4 the the DT cord-259669-fod4xkd7 342 5 Th1 th1 CD cord-259669-fod4xkd7 342 6 / / SYM cord-259669-fod4xkd7 342 7 Th2 th2 CD cord-259669-fod4xkd7 342 8 profile profile NN cord-259669-fod4xkd7 342 9 will will MD cord-259669-fod4xkd7 342 10 be be VB cord-259669-fod4xkd7 342 11 influenced influence VBN cord-259669-fod4xkd7 342 12 by by IN cord-259669-fod4xkd7 342 13 the the DT cord-259669-fod4xkd7 342 14 type type NN cord-259669-fod4xkd7 342 15 of of IN cord-259669-fod4xkd7 342 16 antigen antigen NN cord-259669-fod4xkd7 342 17 presented present VBN cord-259669-fod4xkd7 342 18 as as RB cord-259669-fod4xkd7 342 19 well well RB cord-259669-fod4xkd7 342 20 as as IN cord-259669-fod4xkd7 342 21 by by IN cord-259669-fod4xkd7 342 22 the the DT cord-259669-fod4xkd7 342 23 cytokine cytokine NN cord-259669-fod4xkd7 342 24 environment environment NN cord-259669-fod4xkd7 342 25 [ [ -LRB- cord-259669-fod4xkd7 342 26 88 88 CD cord-259669-fod4xkd7 342 27 ] ] -RRB- cord-259669-fod4xkd7 342 28 . . . cord-259669-fod4xkd7 343 1 Another another DT cord-259669-fod4xkd7 343 2 example example NN cord-259669-fod4xkd7 343 3 of of IN cord-259669-fod4xkd7 343 4 such such JJ cord-259669-fod4xkd7 343 5 modulation modulation NN cord-259669-fod4xkd7 343 6 is be VBZ cord-259669-fod4xkd7 343 7 the the DT cord-259669-fod4xkd7 343 8 observation observation NN cord-259669-fod4xkd7 343 9 that that IN cord-259669-fod4xkd7 343 10 cholera cholera NN cord-259669-fod4xkd7 343 11 toxin toxin NN cord-259669-fod4xkd7 343 12 - - HYPH cord-259669-fod4xkd7 343 13 treated treat VBN cord-259669-fod4xkd7 343 14 DC DC NNP cord-259669-fod4xkd7 343 15 have have VBP cord-259669-fod4xkd7 343 16 the the DT cord-259669-fod4xkd7 343 17 capacity capacity NN cord-259669-fod4xkd7 343 18 to to TO cord-259669-fod4xkd7 343 19 suppress suppress VB cord-259669-fod4xkd7 343 20 T t NN cord-259669-fod4xkd7 343 21 - - HYPH cord-259669-fod4xkd7 343 22 cell cell NN cord-259669-fod4xkd7 343 23 proliferation proliferation NN cord-259669-fod4xkd7 343 24 [ [ -LRB- cord-259669-fod4xkd7 343 25 34 34 CD cord-259669-fod4xkd7 343 26 ] ] -RRB- cord-259669-fod4xkd7 343 27 . . . cord-259669-fod4xkd7 344 1 This this DT cord-259669-fod4xkd7 344 2 was be VBD cord-259669-fod4xkd7 344 3 associated associate VBN cord-259669-fod4xkd7 344 4 with with IN cord-259669-fod4xkd7 344 5 decreased decrease VBN cord-259669-fod4xkd7 344 6 MHC MHC NNP cord-259669-fod4xkd7 344 7 class class NN cord-259669-fod4xkd7 344 8 II II NNP cord-259669-fod4xkd7 344 9 expression expression NN cord-259669-fod4xkd7 344 10 and and CC cord-259669-fod4xkd7 344 11 increased increase VBN cord-259669-fod4xkd7 344 12 IL-10 IL-10 NNP cord-259669-fod4xkd7 344 13 secretion secretion NN cord-259669-fod4xkd7 344 14 of of IN cord-259669-fod4xkd7 344 15 the the DT cord-259669-fod4xkd7 344 16 DC DC NNP cord-259669-fod4xkd7 344 17 and and CC cord-259669-fod4xkd7 344 18 was be VBD cord-259669-fod4xkd7 344 19 reversible reversible JJ cord-259669-fod4xkd7 344 20 by by IN cord-259669-fod4xkd7 344 21 addition addition NN cord-259669-fod4xkd7 344 22 of of IN cord-259669-fod4xkd7 344 23 TNF TNF NNP cord-259669-fod4xkd7 344 24 - - : cord-259669-fod4xkd7 344 25 a a DT cord-259669-fod4xkd7 344 26 suggesting suggest VBG cord-259669-fod4xkd7 344 27 an an DT cord-259669-fod4xkd7 344 28 immunoregulatory immunoregulatory JJ cord-259669-fod4xkd7 344 29 process process NN cord-259669-fod4xkd7 344 30 . . . cord-259669-fod4xkd7 345 1 PRRSV PRRSV NNP cord-259669-fod4xkd7 345 2 has have VBZ cord-259669-fod4xkd7 345 3 also also RB cord-259669-fod4xkd7 345 4 been be VBN cord-259669-fod4xkd7 345 5 described describe VBN cord-259669-fod4xkd7 345 6 by by IN cord-259669-fod4xkd7 345 7 several several JJ cord-259669-fod4xkd7 345 8 authors author NNS cord-259669-fod4xkd7 345 9 to to TO cord-259669-fod4xkd7 345 10 modulate modulate VB cord-259669-fod4xkd7 345 11 DC DC NNP cord-259669-fod4xkd7 345 12 and and CC cord-259669-fod4xkd7 345 13 monocytes monocyte NNS cord-259669-fod4xkd7 345 14 towards towards IN cord-259669-fod4xkd7 345 15 reduced reduce VBN cord-259669-fod4xkd7 345 16 T t NN cord-259669-fod4xkd7 345 17 - - HYPH cord-259669-fod4xkd7 345 18 cell cell NN cord-259669-fod4xkd7 345 19 stimulatory stimulatory JJ cord-259669-fod4xkd7 345 20 capacity capacity NN cord-259669-fod4xkd7 345 21 after after IN cord-259669-fod4xkd7 345 22 in in IN cord-259669-fod4xkd7 345 23 vitro vitro FW cord-259669-fod4xkd7 345 24 infection infection NN cord-259669-fod4xkd7 345 25 [ [ -LRB- cord-259669-fod4xkd7 345 26 102 102 CD cord-259669-fod4xkd7 345 27 , , , cord-259669-fod4xkd7 345 28 103 103 CD cord-259669-fod4xkd7 345 29 ] ] -RRB- cord-259669-fod4xkd7 345 30 . . . cord-259669-fod4xkd7 346 1 Also also RB cord-259669-fod4xkd7 346 2 here here RB cord-259669-fod4xkd7 346 3 reduced reduce VBN cord-259669-fod4xkd7 346 4 expression expression NN cord-259669-fod4xkd7 346 5 of of IN cord-259669-fod4xkd7 346 6 MHC MHC NNP cord-259669-fod4xkd7 346 7 and and CC cord-259669-fod4xkd7 346 8 costimulatory costimulatory NNP cord-259669-fod4xkd7 346 9 molecules molecule NNS cord-259669-fod4xkd7 346 10 together together RB cord-259669-fod4xkd7 346 11 with with IN cord-259669-fod4xkd7 346 12 increased increase VBN cord-259669-fod4xkd7 346 13 IL-10 IL-10 NNP cord-259669-fod4xkd7 346 14 levels level NNS cord-259669-fod4xkd7 346 15 have have VBP cord-259669-fod4xkd7 346 16 been be VBN cord-259669-fod4xkd7 346 17 described describe VBN cord-259669-fod4xkd7 346 18 [ [ -LRB- cord-259669-fod4xkd7 346 19 101 101 CD cord-259669-fod4xkd7 346 20 ] ] -RRB- cord-259669-fod4xkd7 346 21 [ [ -LRB- cord-259669-fod4xkd7 346 22 102 102 CD cord-259669-fod4xkd7 346 23 ] ] -RRB- cord-259669-fod4xkd7 346 24 [ [ -LRB- cord-259669-fod4xkd7 346 25 103 103 CD cord-259669-fod4xkd7 346 26 ] ] -RRB- cord-259669-fod4xkd7 346 27 115 115 CD cord-259669-fod4xkd7 346 28 ] ] -RRB- cord-259669-fod4xkd7 346 29 . . . cord-259669-fod4xkd7 347 1 Such such JJ cord-259669-fod4xkd7 347 2 studies study NNS cord-259669-fod4xkd7 347 3 are be VBP cord-259669-fod4xkd7 347 4 valuable valuable JJ cord-259669-fod4xkd7 347 5 to to TO cord-259669-fod4xkd7 347 6 understand understand VB cord-259669-fod4xkd7 347 7 viral viral JJ cord-259669-fod4xkd7 347 8 pathogenesis pathogenesis NN cord-259669-fod4xkd7 347 9 but but CC cord-259669-fod4xkd7 347 10 care care NN cord-259669-fod4xkd7 347 11 must must MD cord-259669-fod4xkd7 347 12 be be VB cord-259669-fod4xkd7 347 13 taken take VBN cord-259669-fod4xkd7 347 14 to to TO cord-259669-fod4xkd7 347 15 avoid avoid VB cord-259669-fod4xkd7 347 16 any any DT cord-259669-fod4xkd7 347 17 contamination contamination NN cord-259669-fod4xkd7 347 18 of of IN cord-259669-fod4xkd7 347 19 the the DT cord-259669-fod4xkd7 347 20 cultures culture NNS cord-259669-fod4xkd7 347 21 with with IN cord-259669-fod4xkd7 347 22 mycoplasma mycoplasma NN cord-259669-fod4xkd7 347 23 as as IN cord-259669-fod4xkd7 347 24 MoDC MoDC NNP cord-259669-fod4xkd7 347 25 cultures culture NNS cord-259669-fod4xkd7 347 26 apparently apparently RB cord-259669-fod4xkd7 347 27 efficiently efficiently RB cord-259669-fod4xkd7 347 28 support support VBP cord-259669-fod4xkd7 347 29 mycoplasma mycoplasma NN cord-259669-fod4xkd7 347 30 growth growth NN cord-259669-fod4xkd7 347 31 , , , cord-259669-fod4xkd7 347 32 which which WDT cord-259669-fod4xkd7 347 33 can can MD cord-259669-fod4xkd7 347 34 result result VB cord-259669-fod4xkd7 347 35 in in IN cord-259669-fod4xkd7 347 36 a a DT cord-259669-fod4xkd7 347 37 potent potent JJ cord-259669-fod4xkd7 347 38 antiproliferative antiproliferative JJ cord-259669-fod4xkd7 347 39 activity activity NN cord-259669-fod4xkd7 347 40 [ [ -LRB- cord-259669-fod4xkd7 347 41 116 116 CD cord-259669-fod4xkd7 347 42 ] ] -RRB- cord-259669-fod4xkd7 347 43 . . . cord-259669-fod4xkd7 348 1 DC DC NNP cord-259669-fod4xkd7 348 2 not not RB cord-259669-fod4xkd7 348 3 only only RB cord-259669-fod4xkd7 348 4 determine determine VB cord-259669-fod4xkd7 348 5 the the DT cord-259669-fod4xkd7 348 6 type type NN cord-259669-fod4xkd7 348 7 of of IN cord-259669-fod4xkd7 348 8 T t NN cord-259669-fod4xkd7 348 9 - - HYPH cord-259669-fod4xkd7 348 10 cell cell NN cord-259669-fod4xkd7 348 11 response response NN cord-259669-fod4xkd7 348 12 but but CC cord-259669-fod4xkd7 348 13 also also RB cord-259669-fod4xkd7 348 14 their -PRON- PRP$ cord-259669-fod4xkd7 348 15 homing homing NN cord-259669-fod4xkd7 348 16 characteristics characteristic NNS cord-259669-fod4xkd7 348 17 . . . cord-259669-fod4xkd7 349 1 As as IN cord-259669-fod4xkd7 349 2 described describe VBN cord-259669-fod4xkd7 349 3 in in IN cord-259669-fod4xkd7 349 4 section section NN cord-259669-fod4xkd7 349 5 ' ' '' cord-259669-fod4xkd7 349 6 ' ' '' cord-259669-fod4xkd7 349 7 Mucosal Mucosal NNP cord-259669-fod4xkd7 349 8 DC DC NNP cord-259669-fod4xkd7 349 9 ' ' '' cord-259669-fod4xkd7 349 10 ' ' '' cord-259669-fod4xkd7 349 11 , , , cord-259669-fod4xkd7 349 12 MoDC MoDC NNP cord-259669-fod4xkd7 349 13 treated treat VBN cord-259669-fod4xkd7 349 14 with with IN cord-259669-fod4xkd7 349 15 RA RA NNP cord-259669-fod4xkd7 349 16 promote promote VB cord-259669-fod4xkd7 349 17 a4b7 a4b7 NNP cord-259669-fod4xkd7 349 18 and and CC cord-259669-fod4xkd7 349 19 CCR9 ccr9 JJ cord-259669-fod4xkd7 349 20 expression expression NN cord-259669-fod4xkd7 349 21 , , , cord-259669-fod4xkd7 349 22 representing represent VBG cord-259669-fod4xkd7 349 23 essential essential JJ cord-259669-fod4xkd7 349 24 gut gut NN cord-259669-fod4xkd7 349 25 homing homing NN cord-259669-fod4xkd7 349 26 receptors receptor NNS cord-259669-fod4xkd7 349 27 [ [ -LRB- cord-259669-fod4xkd7 349 28 75 75 CD cord-259669-fod4xkd7 349 29 ] ] -RRB- cord-259669-fod4xkd7 349 30 . . . cord-259669-fod4xkd7 350 1 Classically classically RB cord-259669-fod4xkd7 350 2 , , , cord-259669-fod4xkd7 350 3 B b NN cord-259669-fod4xkd7 350 4 lymphocytes lymphocyte NNS cord-259669-fod4xkd7 350 5 equipped equip VBN cord-259669-fod4xkd7 350 6 with with IN cord-259669-fod4xkd7 350 7 their -PRON- PRP$ cord-259669-fod4xkd7 350 8 surface surface NN cord-259669-fod4xkd7 351 1 Ig Ig NNP cord-259669-fod4xkd7 351 2 receptor receptor NN cord-259669-fod4xkd7 351 3 will will MD cord-259669-fod4xkd7 351 4 recognize recognize VB cord-259669-fod4xkd7 351 5 native native JJ cord-259669-fod4xkd7 351 6 unprocessed unprocessed JJ cord-259669-fod4xkd7 351 7 antigen antigen NN cord-259669-fod4xkd7 351 8 and and CC cord-259669-fod4xkd7 351 9 would would MD cord-259669-fod4xkd7 351 10 only only RB cord-259669-fod4xkd7 351 11 require require VB cord-259669-fod4xkd7 351 12 T t NN cord-259669-fod4xkd7 351 13 - - HYPH cord-259669-fod4xkd7 351 14 cell cell NN cord-259669-fod4xkd7 351 15 help help NN cord-259669-fod4xkd7 351 16 for for IN cord-259669-fod4xkd7 351 17 clonal clonal JJ cord-259669-fod4xkd7 351 18 expansion expansion NN cord-259669-fod4xkd7 351 19 and and CC cord-259669-fod4xkd7 351 20 differentiation differentiation NN cord-259669-fod4xkd7 351 21 into into IN cord-259669-fod4xkd7 351 22 antibody antibody NN cord-259669-fod4xkd7 351 23 producing produce VBG cord-259669-fod4xkd7 351 24 cells cell NNS cord-259669-fod4xkd7 351 25 . . . cord-259669-fod4xkd7 352 1 In in IN cord-259669-fod4xkd7 352 2 this this DT cord-259669-fod4xkd7 352 3 sense sense NN cord-259669-fod4xkd7 352 4 , , , cord-259669-fod4xkd7 352 5 B b NN cord-259669-fod4xkd7 352 6 cells cell NNS cord-259669-fod4xkd7 352 7 should should MD cord-259669-fod4xkd7 352 8 show show VB cord-259669-fod4xkd7 352 9 only only RB cord-259669-fod4xkd7 352 10 an an DT cord-259669-fod4xkd7 352 11 indirect indirect JJ cord-259669-fod4xkd7 352 12 requirement requirement NN cord-259669-fod4xkd7 352 13 for for IN cord-259669-fod4xkd7 352 14 APC APC NNP cord-259669-fod4xkd7 352 15 such such JJ cord-259669-fod4xkd7 352 16 as as IN cord-259669-fod4xkd7 352 17 cDC cDC NNP cord-259669-fod4xkd7 352 18 . . . cord-259669-fod4xkd7 353 1 Nevertheless nevertheless RB cord-259669-fod4xkd7 353 2 , , , cord-259669-fod4xkd7 353 3 APC APC NNP cord-259669-fod4xkd7 353 4 produce produce VBP cord-259669-fod4xkd7 353 5 a a DT cord-259669-fod4xkd7 353 6 number number NN cord-259669-fod4xkd7 353 7 of of IN cord-259669-fod4xkd7 353 8 cytokines cytokine NNS cord-259669-fod4xkd7 353 9 , , , cord-259669-fod4xkd7 353 10 which which WDT cord-259669-fod4xkd7 353 11 have have VBP cord-259669-fod4xkd7 353 12 a a DT cord-259669-fod4xkd7 353 13 direct direct JJ cord-259669-fod4xkd7 353 14 stimulatory stimulatory JJ cord-259669-fod4xkd7 353 15 effect effect NN cord-259669-fod4xkd7 353 16 on on IN cord-259669-fod4xkd7 353 17 B b NN cord-259669-fod4xkd7 353 18 cells cell NNS cord-259669-fod4xkd7 353 19 . . . cord-259669-fod4xkd7 354 1 These these DT cord-259669-fod4xkd7 354 2 are be VBP cord-259669-fod4xkd7 354 3 classical classical JJ cord-259669-fod4xkd7 354 4 cytokines cytokine NNS cord-259669-fod4xkd7 354 5 such such JJ cord-259669-fod4xkd7 354 6 as as IN cord-259669-fod4xkd7 354 7 IL-6 IL-6 NNP cord-259669-fod4xkd7 354 8 , , , cord-259669-fod4xkd7 354 9 IL-10 IL-10 NNP cord-259669-fod4xkd7 354 10 and and CC cord-259669-fod4xkd7 354 11 IFN-(/b IFN-(/b NNP cord-259669-fod4xkd7 354 12 , , . cord-259669-fod4xkd7 355 1 but but CC cord-259669-fod4xkd7 355 2 also also RB cord-259669-fod4xkd7 355 3 more more RBR cord-259669-fod4xkd7 355 4 recently recently RB cord-259669-fod4xkd7 355 5 identified identify VBN cord-259669-fod4xkd7 355 6 cytokines cytokine NNS cord-259669-fod4xkd7 355 7 such such JJ cord-259669-fod4xkd7 355 8 as as IN cord-259669-fod4xkd7 355 9 the the DT cord-259669-fod4xkd7 355 10 B b NN cord-259669-fod4xkd7 355 11 - - HYPH cord-259669-fod4xkd7 355 12 cell cell NN cord-259669-fod4xkd7 355 13 activating activate VBG cord-259669-fod4xkd7 355 14 factor factor NN cord-259669-fod4xkd7 355 15 ( ( -LRB- cord-259669-fod4xkd7 355 16 BAFF BAFF NNP cord-259669-fod4xkd7 355 17 ) ) -RRB- cord-259669-fod4xkd7 355 18 and and CC cord-259669-fod4xkd7 355 19 a a DT cord-259669-fod4xkd7 355 20 proliferation proliferation NN cord-259669-fod4xkd7 355 21 - - HYPH cord-259669-fod4xkd7 355 22 inducing induce VBG cord-259669-fod4xkd7 355 23 ligand ligand NN cord-259669-fod4xkd7 355 24 ( ( -LRB- cord-259669-fod4xkd7 355 25 APRIL)-members april)-member NNS cord-259669-fod4xkd7 355 26 of of IN cord-259669-fod4xkd7 355 27 the the DT cord-259669-fod4xkd7 355 28 tumour tumour NN cord-259669-fod4xkd7 355 29 necrosis necrosis NN cord-259669-fod4xkd7 355 30 factor factor NN cord-259669-fod4xkd7 355 31 superfamily superfamily NN cord-259669-fod4xkd7 355 32 [ [ -LRB- cord-259669-fod4xkd7 355 33 9 9 CD cord-259669-fod4xkd7 355 34 ] ] -RRB- cord-259669-fod4xkd7 355 35 . . . cord-259669-fod4xkd7 356 1 In in IN cord-259669-fod4xkd7 356 2 addition addition NN cord-259669-fod4xkd7 356 3 , , , cord-259669-fod4xkd7 356 4 several several JJ cord-259669-fod4xkd7 356 5 studies study NNS cord-259669-fod4xkd7 356 6 also also RB cord-259669-fod4xkd7 356 7 demonstrated demonstrate VBD cord-259669-fod4xkd7 356 8 the the DT cord-259669-fod4xkd7 356 9 ' ' '' cord-259669-fod4xkd7 356 10 ' ' `` cord-259669-fod4xkd7 356 11 delivery delivery NN cord-259669-fod4xkd7 356 12 ' ' '' cord-259669-fod4xkd7 356 13 ' ' '' cord-259669-fod4xkd7 356 14 of of IN cord-259669-fod4xkd7 356 15 native native JJ cord-259669-fod4xkd7 356 16 unprocessed unprocessed JJ cord-259669-fod4xkd7 356 17 antigen antigen NN cord-259669-fod4xkd7 356 18 by by IN cord-259669-fod4xkd7 356 19 DC DC NNP cord-259669-fod4xkd7 356 20 to to IN cord-259669-fod4xkd7 356 21 B b NN cord-259669-fod4xkd7 356 22 cells cell NNS cord-259669-fod4xkd7 356 23 [ [ -LRB- cord-259669-fod4xkd7 356 24 5 5 CD cord-259669-fod4xkd7 356 25 ] ] -RRB- cord-259669-fod4xkd7 356 26 [ [ -LRB- cord-259669-fod4xkd7 356 27 6 6 CD cord-259669-fod4xkd7 356 28 ] ] -RRB- cord-259669-fod4xkd7 356 29 [ [ -LRB- cord-259669-fod4xkd7 356 30 7 7 CD cord-259669-fod4xkd7 356 31 ] ] -RRB- cord-259669-fod4xkd7 356 32 . . . cord-259669-fod4xkd7 357 1 Our -PRON- PRP$ cord-259669-fod4xkd7 357 2 own own JJ cord-259669-fod4xkd7 357 3 studies study NNS cord-259669-fod4xkd7 357 4 with with IN cord-259669-fod4xkd7 357 5 porcine porcine JJ cord-259669-fod4xkd7 357 6 DC DC NNP cord-259669-fod4xkd7 357 7 in in IN cord-259669-fod4xkd7 357 8 an an DT cord-259669-fod4xkd7 357 9 in in FW cord-259669-fod4xkd7 357 10 vitro vitro FW cord-259669-fod4xkd7 357 11 model model NN cord-259669-fod4xkd7 357 12 of of IN cord-259669-fod4xkd7 357 13 FMDV fmdv NN cord-259669-fod4xkd7 357 14 - - HYPH cord-259669-fod4xkd7 357 15 specific specific JJ cord-259669-fod4xkd7 357 16 Ig Ig NNP cord-259669-fod4xkd7 357 17 synthesis synthesis NN cord-259669-fod4xkd7 357 18 demonstrated demonstrate VBD cord-259669-fod4xkd7 357 19 an an DT cord-259669-fod4xkd7 357 20 important important JJ cord-259669-fod4xkd7 357 21 direct direct JJ cord-259669-fod4xkd7 357 22 role role NN cord-259669-fod4xkd7 357 23 of of IN cord-259669-fod4xkd7 357 24 APC APC NNP cord-259669-fod4xkd7 357 25 's 's POS cord-259669-fod4xkd7 357 26 during during IN cord-259669-fod4xkd7 357 27 antigenspecific antigenspecific JJ cord-259669-fod4xkd7 357 28 restimulation restimulation NN cord-259669-fod4xkd7 357 29 of of IN cord-259669-fod4xkd7 357 30 immune immune JJ cord-259669-fod4xkd7 357 31 B b NN cord-259669-fod4xkd7 357 32 lymphocytes lymphocyte NNS cord-259669-fod4xkd7 357 33 . . . cord-259669-fod4xkd7 358 1 Purified purify VBN cord-259669-fod4xkd7 358 2 B B NNP cord-259669-fod4xkd7 358 3 cells cell NNS cord-259669-fod4xkd7 358 4 produced produce VBD cord-259669-fod4xkd7 358 5 virusspecific virusspecific NNP cord-259669-fod4xkd7 358 6 Ig Ig NNP cord-259669-fod4xkd7 358 7 only only RB cord-259669-fod4xkd7 358 8 in in IN cord-259669-fod4xkd7 358 9 the the DT cord-259669-fod4xkd7 358 10 presence presence NN cord-259669-fod4xkd7 358 11 of of IN cord-259669-fod4xkd7 358 12 Tcells Tcells NNP cord-259669-fod4xkd7 358 13 and and CC cord-259669-fod4xkd7 358 14 APC APC NNP cord-259669-fod4xkd7 358 15 . . . cord-259669-fod4xkd7 359 1 Monocytes monocyte NNS cord-259669-fod4xkd7 359 2 and and CC cord-259669-fod4xkd7 359 3 MoDC modc JJ cord-259669-fod4xkd7 359 4 but but CC cord-259669-fod4xkd7 359 5 not not RB cord-259669-fod4xkd7 359 6 pDC pDC NNP cord-259669-fod4xkd7 359 7 supported support VBN cord-259669-fod4xkd7 359 8 B b NN cord-259669-fod4xkd7 359 9 - - HYPH cord-259669-fod4xkd7 359 10 cell cell NN cord-259669-fod4xkd7 359 11 differentiation differentiation NN cord-259669-fod4xkd7 359 12 into into IN cord-259669-fod4xkd7 359 13 antibody antibody NN cord-259669-fod4xkd7 359 14 - - HYPH cord-259669-fod4xkd7 359 15 secreting secrete VBG cord-259669-fod4xkd7 359 16 cells cell NNS cord-259669-fod4xkd7 359 17 . . . cord-259669-fod4xkd7 360 1 While while IN cord-259669-fod4xkd7 360 2 IL-2 IL-2 NNP cord-259669-fod4xkd7 360 3 could could MD cord-259669-fod4xkd7 360 4 replace replace VB cord-259669-fod4xkd7 360 5 T T NNP cord-259669-fod4xkd7 360 6 - - HYPH cord-259669-fod4xkd7 360 7 cells cell NNS cord-259669-fod4xkd7 360 8 , , , cord-259669-fod4xkd7 360 9 addition addition NN cord-259669-fod4xkd7 360 10 of of IN cord-259669-fod4xkd7 360 11 BAFF BAFF NNP cord-259669-fod4xkd7 360 12 could could MD cord-259669-fod4xkd7 360 13 compensate compensate VB cord-259669-fod4xkd7 360 14 for for IN cord-259669-fod4xkd7 360 15 a a DT cord-259669-fod4xkd7 360 16 lack lack NN cord-259669-fod4xkd7 360 17 of of IN cord-259669-fod4xkd7 360 18 APC APC NNP cord-259669-fod4xkd7 360 19 . . . cord-259669-fod4xkd7 361 1 In in IN cord-259669-fod4xkd7 361 2 fact fact NN cord-259669-fod4xkd7 361 3 , , , cord-259669-fod4xkd7 361 4 blocking block VBG cord-259669-fod4xkd7 361 5 of of IN cord-259669-fod4xkd7 361 6 BAFF BAFF NNP cord-259669-fod4xkd7 361 7 receptor receptor NN cord-259669-fod4xkd7 361 8 abrogated abrogate VBD cord-259669-fod4xkd7 361 9 the the DT cord-259669-fod4xkd7 361 10 APC APC NNP cord-259669-fod4xkd7 361 11 - - HYPH cord-259669-fod4xkd7 361 12 derived derive VBN cord-259669-fod4xkd7 361 13 help help NN cord-259669-fod4xkd7 361 14 for for IN cord-259669-fod4xkd7 361 15 Bcell Bcell NNP cord-259669-fod4xkd7 361 16 responses response NNS cord-259669-fod4xkd7 361 17 [ [ -LRB- cord-259669-fod4xkd7 361 18 41 41 CD cord-259669-fod4xkd7 361 19 ] ] -RRB- cord-259669-fod4xkd7 361 20 . . . cord-259669-fod4xkd7 362 1 In in IN cord-259669-fod4xkd7 362 2 addition addition NN cord-259669-fod4xkd7 362 3 , , , cord-259669-fod4xkd7 362 4 DC DC NNP cord-259669-fod4xkd7 362 5 also also RB cord-259669-fod4xkd7 362 6 influence influence VBP cord-259669-fod4xkd7 362 7 isotype isotype NN cord-259669-fod4xkd7 362 8 switching switch VBG cord-259669-fod4xkd7 362 9 . . . cord-259669-fod4xkd7 363 1 As as IN cord-259669-fod4xkd7 363 2 mentioned mention VBN cord-259669-fod4xkd7 363 3 above above RB cord-259669-fod4xkd7 363 4 , , , cord-259669-fod4xkd7 363 5 RA RA NNP cord-259669-fod4xkd7 363 6 - - HYPH cord-259669-fod4xkd7 363 7 treated treat VBN cord-259669-fod4xkd7 363 8 MoDC MoDC NNP cord-259669-fod4xkd7 363 9 promote promote VB cord-259669-fod4xkd7 363 10 virus virus NN cord-259669-fod4xkd7 363 11 - - HYPH cord-259669-fod4xkd7 363 12 specific specific JJ cord-259669-fod4xkd7 363 13 IgA IgA NNP cord-259669-fod4xkd7 363 14 secretion secretion NN cord-259669-fod4xkd7 364 1 in in IN cord-259669-fod4xkd7 364 2 vitro vitro FW cord-259669-fod4xkd7 364 3 [ [ -LRB- cord-259669-fod4xkd7 364 4 75 75 CD cord-259669-fod4xkd7 364 5 ] ] -RRB- cord-259669-fod4xkd7 364 6 . . . cord-259669-fod4xkd7 365 1 Not not RB cord-259669-fod4xkd7 365 2 surprisingly surprisingly RB cord-259669-fod4xkd7 365 3 , , , cord-259669-fod4xkd7 365 4 similar similar JJ cord-259669-fod4xkd7 365 5 to to IN cord-259669-fod4xkd7 365 6 the the DT cord-259669-fod4xkd7 365 7 interaction interaction NN cord-259669-fod4xkd7 365 8 with with IN cord-259669-fod4xkd7 365 9 T t NN cord-259669-fod4xkd7 365 10 lymphocytes lymphocyte NNS cord-259669-fod4xkd7 365 11 , , , cord-259669-fod4xkd7 365 12 the the DT cord-259669-fod4xkd7 365 13 interplay interplay NN cord-259669-fod4xkd7 365 14 of of IN cord-259669-fod4xkd7 365 15 DC DC NNP cord-259669-fod4xkd7 365 16 with with IN cord-259669-fod4xkd7 365 17 B b NN cord-259669-fod4xkd7 365 18 lymphocytes lymphocyte NNS cord-259669-fod4xkd7 365 19 is be VBZ cord-259669-fod4xkd7 365 20 also also RB cord-259669-fod4xkd7 365 21 bilateral bilateral JJ cord-259669-fod4xkd7 365 22 . . . cord-259669-fod4xkd7 366 1 An an DT cord-259669-fod4xkd7 366 2 important important JJ cord-259669-fod4xkd7 366 3 role role NN cord-259669-fod4xkd7 366 4 is be VBZ cord-259669-fod4xkd7 366 5 certainly certainly RB cord-259669-fod4xkd7 366 6 played play VBN cord-259669-fod4xkd7 366 7 by by IN cord-259669-fod4xkd7 366 8 the the DT cord-259669-fod4xkd7 366 9 ' ' `` cord-259669-fod4xkd7 366 10 ' ' `` cord-259669-fod4xkd7 366 11 mé mé NNP cord-259669-fod4xkd7 366 12 nage nage FW cord-259669-fod4xkd7 366 13 à à FW cord-259669-fod4xkd7 366 14 trois trois FW cord-259669-fod4xkd7 366 15 ' ' '' cord-259669-fod4xkd7 366 16 ' ' '' cord-259669-fod4xkd7 366 17 of of IN cord-259669-fod4xkd7 366 18 FcR FcR NNP cord-259669-fod4xkd7 366 19 expressed express VBN cord-259669-fod4xkd7 366 20 on on IN cord-259669-fod4xkd7 366 21 DC DC NNP cord-259669-fod4xkd7 366 22 , , , cord-259669-fod4xkd7 366 23 antibody antibody NN cord-259669-fod4xkd7 366 24 and and CC cord-259669-fod4xkd7 366 25 antigen antigen NN cord-259669-fod4xkd7 366 26 . . . cord-259669-fod4xkd7 367 1 This this DT cord-259669-fod4xkd7 367 2 permits permit VBZ cord-259669-fod4xkd7 367 3 an an DT cord-259669-fod4xkd7 367 4 amplification amplification NN cord-259669-fod4xkd7 367 5 of of IN cord-259669-fod4xkd7 367 6 antigen antigen NN cord-259669-fod4xkd7 367 7 uptake uptake NN cord-259669-fod4xkd7 367 8 and and CC cord-259669-fod4xkd7 367 9 presentation presentation NN cord-259669-fod4xkd7 367 10 , , , cord-259669-fod4xkd7 367 11 and and CC cord-259669-fod4xkd7 367 12 can can MD cord-259669-fod4xkd7 367 13 also also RB cord-259669-fod4xkd7 367 14 mediate mediate VB cord-259669-fod4xkd7 367 15 efficient efficient JJ cord-259669-fod4xkd7 367 16 cross cross NN cord-259669-fod4xkd7 367 17 - - NN cord-259669-fod4xkd7 367 18 presentation presentation NN cord-259669-fod4xkd7 367 19 of of IN cord-259669-fod4xkd7 367 20 antigen antigen NN cord-259669-fod4xkd7 367 21 for for IN cord-259669-fod4xkd7 367 22 stimulation stimulation NN cord-259669-fod4xkd7 367 23 of of IN cord-259669-fod4xkd7 367 24 MHC MHC NNP cord-259669-fod4xkd7 367 25 class class NN cord-259669-fod4xkd7 367 26 I i NN cord-259669-fod4xkd7 367 27 - - HYPH cord-259669-fod4xkd7 367 28 restricted restrict VBN cord-259669-fod4xkd7 367 29 T t NN cord-259669-fod4xkd7 367 30 - - HYPH cord-259669-fod4xkd7 367 31 cell cell NN cord-259669-fod4xkd7 367 32 responses response NNS cord-259669-fod4xkd7 367 33 . . . cord-259669-fod4xkd7 368 1 Furthermore furthermore RB cord-259669-fod4xkd7 368 2 , , , cord-259669-fod4xkd7 368 3 the the DT cord-259669-fod4xkd7 368 4 FcRsystem FcRsystem NNP cord-259669-fod4xkd7 368 5 sensitizes sensitize VBZ cord-259669-fod4xkd7 368 6 DC DC NNP cord-259669-fod4xkd7 368 7 for for IN cord-259669-fod4xkd7 368 8 inflammatory inflammatory JJ cord-259669-fod4xkd7 368 9 and and CC cord-259669-fod4xkd7 368 10 antiviral antiviral JJ cord-259669-fod4xkd7 368 11 cytokine cytokine NN cord-259669-fod4xkd7 368 12 responses response NNS cord-259669-fod4xkd7 368 13 . . . cord-259669-fod4xkd7 369 1 One one CD cord-259669-fod4xkd7 369 2 example example NN cord-259669-fod4xkd7 369 3 is be VBZ cord-259669-fod4xkd7 369 4 the the DT cord-259669-fod4xkd7 369 5 response response NN cord-259669-fod4xkd7 369 6 of of IN cord-259669-fod4xkd7 369 7 pDC pDC NNP cord-259669-fod4xkd7 369 8 to to IN cord-259669-fod4xkd7 369 9 FMDV FMDV NNP cord-259669-fod4xkd7 369 10 mentioned mention VBN cord-259669-fod4xkd7 369 11 above above RB cord-259669-fod4xkd7 369 12 ( ( -LRB- cord-259669-fod4xkd7 369 13 Table table NN cord-259669-fod4xkd7 369 14 4 4 CD cord-259669-fod4xkd7 369 15 ) ) -RRB- cord-259669-fod4xkd7 369 16 . . . cord-259669-fod4xkd7 370 1 These these DT cord-259669-fod4xkd7 370 2 pDC pdc CD cord-259669-fod4xkd7 370 3 only only RB cord-259669-fod4xkd7 370 4 respond respond VB cord-259669-fod4xkd7 370 5 by by IN cord-259669-fod4xkd7 370 6 producing produce VBG cord-259669-fod4xkd7 370 7 IFN- IFN- NNP cord-259669-fod4xkd7 370 8 ( ( -LRB- cord-259669-fod4xkd7 370 9 to to TO cord-259669-fod4xkd7 370 10 FMDV fmdv VB cord-259669-fod4xkd7 370 11 when when WRB cord-259669-fod4xkd7 370 12 the the DT cord-259669-fod4xkd7 370 13 virus virus NN cord-259669-fod4xkd7 370 14 is be VBZ cord-259669-fod4xkd7 370 15 complexed complexe VBN cord-259669-fod4xkd7 370 16 with with IN cord-259669-fod4xkd7 370 17 antibodies antibody NNS cord-259669-fod4xkd7 370 18 [ [ -LRB- cord-259669-fod4xkd7 370 19 63 63 CD cord-259669-fod4xkd7 370 20 ] ] -RRB- cord-259669-fod4xkd7 370 21 . . . cord-259669-fod4xkd7 371 1 Another another DT cord-259669-fod4xkd7 371 2 example example NN cord-259669-fod4xkd7 371 3 is be VBZ cord-259669-fod4xkd7 371 4 with with IN cord-259669-fod4xkd7 371 5 CSFV CSFV NNP cord-259669-fod4xkd7 371 6 , , , cord-259669-fod4xkd7 371 7 where where WRB cord-259669-fod4xkd7 371 8 pDC pDC NNP cord-259669-fod4xkd7 371 9 sensitized sensitize VBN cord-259669-fod4xkd7 371 10 with with IN cord-259669-fod4xkd7 371 11 cytophilic cytophilic NNP cord-259669-fod4xkd7 371 12 antibodies antibody NNS cord-259669-fod4xkd7 371 13 show show VBP cord-259669-fod4xkd7 371 14 enhanced enhance VBN cord-259669-fod4xkd7 371 15 IFN- IFN- NNP cord-259669-fod4xkd7 371 16 ( ( -LRB- cord-259669-fod4xkd7 371 17 production production NN cord-259669-fod4xkd7 371 18 in in IN cord-259669-fod4xkd7 371 19 response response NN cord-259669-fod4xkd7 371 20 to to TO cord-259669-fod4xkd7 371 21 lower lower VB cord-259669-fod4xkd7 371 22 virus virus NN cord-259669-fod4xkd7 371 23 quantities quantity NNS cord-259669-fod4xkd7 371 24 than than IN cord-259669-fod4xkd7 371 25 when when WRB cord-259669-fod4xkd7 371 26 no no DT cord-259669-fod4xkd7 371 27 cytophilic cytophilic NN cord-259669-fod4xkd7 371 28 antibodies antibody NNS cord-259669-fod4xkd7 371 29 are be VBP cord-259669-fod4xkd7 371 30 present present JJ cord-259669-fod4xkd7 371 31 [ [ -LRB- cord-259669-fod4xkd7 371 32 57 57 CD cord-259669-fod4xkd7 371 33 ] ] -RRB- cord-259669-fod4xkd7 371 34 . . . cord-259669-fod4xkd7 372 1 In in IN cord-259669-fod4xkd7 372 2 both both DT cord-259669-fod4xkd7 372 3 cases case NNS cord-259669-fod4xkd7 372 4 FcgRII FcgRII NNP cord-259669-fod4xkd7 372 5 is be VBZ cord-259669-fod4xkd7 372 6 involved involve VBN cord-259669-fod4xkd7 372 7 . . . cord-259669-fod4xkd7 373 1 Recent recent JJ cord-259669-fod4xkd7 373 2 advances advance NNS cord-259669-fod4xkd7 373 3 in in IN cord-259669-fod4xkd7 373 4 the the DT cord-259669-fod4xkd7 373 5 characterization characterization NN cord-259669-fod4xkd7 373 6 of of IN cord-259669-fod4xkd7 373 7 the the DT cord-259669-fod4xkd7 373 8 porcine porcine JJ cord-259669-fod4xkd7 373 9 immune immune JJ cord-259669-fod4xkd7 373 10 system system NN cord-259669-fod4xkd7 373 11 , , , cord-259669-fod4xkd7 373 12 particularly particularly RB cord-259669-fod4xkd7 373 13 in in IN cord-259669-fod4xkd7 373 14 porcine porcine JJ cord-259669-fod4xkd7 373 15 DC DC NNP cord-259669-fod4xkd7 373 16 biology biology NN cord-259669-fod4xkd7 373 17 , , , cord-259669-fod4xkd7 373 18 have have VBP cord-259669-fod4xkd7 373 19 permitted permit VBN cord-259669-fod4xkd7 373 20 the the DT cord-259669-fod4xkd7 373 21 use use NN cord-259669-fod4xkd7 373 22 of of IN cord-259669-fod4xkd7 373 23 the the DT cord-259669-fod4xkd7 373 24 porcine porcine JJ cord-259669-fod4xkd7 373 25 model model NN cord-259669-fod4xkd7 373 26 for for IN cord-259669-fod4xkd7 373 27 many many JJ cord-259669-fod4xkd7 373 28 immunological immunological JJ cord-259669-fod4xkd7 373 29 studies study NNS cord-259669-fod4xkd7 373 30 . . . cord-259669-fod4xkd7 374 1 Although although IN cord-259669-fod4xkd7 374 2 the the DT cord-259669-fod4xkd7 374 3 library library NN cord-259669-fod4xkd7 374 4 of of IN cord-259669-fod4xkd7 374 5 reagents reagent NNS cord-259669-fod4xkd7 374 6 for for IN cord-259669-fod4xkd7 374 7 such such JJ cord-259669-fod4xkd7 374 8 studies study NNS cord-259669-fod4xkd7 374 9 is be VBZ cord-259669-fod4xkd7 374 10 still still RB cord-259669-fod4xkd7 374 11 restricted restrict VBN cord-259669-fod4xkd7 374 12 compared compare VBN cord-259669-fod4xkd7 374 13 to to IN cord-259669-fod4xkd7 374 14 that that DT cord-259669-fod4xkd7 374 15 for for IN cord-259669-fod4xkd7 374 16 mouse mouse NN cord-259669-fod4xkd7 374 17 and and CC cord-259669-fod4xkd7 374 18 human human JJ cord-259669-fod4xkd7 374 19 studies study NNS cord-259669-fod4xkd7 374 20 , , , cord-259669-fod4xkd7 374 21 knowledge knowledge NN cord-259669-fod4xkd7 374 22 of of IN cord-259669-fod4xkd7 374 23 porcine porcine JJ cord-259669-fod4xkd7 374 24 immunology immunology NN cord-259669-fod4xkd7 374 25 is be VBZ cord-259669-fod4xkd7 374 26 well well RB cord-259669-fod4xkd7 374 27 advanced advanced JJ cord-259669-fod4xkd7 374 28 . . . cord-259669-fod4xkd7 375 1 With with IN cord-259669-fod4xkd7 375 2 the the DT cord-259669-fod4xkd7 375 3 unveiling unveiling NN cord-259669-fod4xkd7 375 4 of of IN cord-259669-fod4xkd7 375 5 the the DT cord-259669-fod4xkd7 375 6 sequence sequence NN cord-259669-fod4xkd7 375 7 for for IN cord-259669-fod4xkd7 375 8 the the DT cord-259669-fod4xkd7 375 9 porcine porcine JJ cord-259669-fod4xkd7 375 10 genome genome NN cord-259669-fod4xkd7 375 11 , , , cord-259669-fod4xkd7 375 12 there there EX cord-259669-fod4xkd7 375 13 will will MD cord-259669-fod4xkd7 375 14 be be VB cord-259669-fod4xkd7 375 15 clear clear JJ cord-259669-fod4xkd7 375 16 advantages advantage NNS cord-259669-fod4xkd7 375 17 for for IN cord-259669-fod4xkd7 375 18 using use VBG cord-259669-fod4xkd7 375 19 the the DT cord-259669-fod4xkd7 375 20 pig pig NN cord-259669-fod4xkd7 375 21 . . . cord-259669-fod4xkd7 376 1 In in IN cord-259669-fod4xkd7 376 2 particular particular JJ cord-259669-fod4xkd7 376 3 , , , cord-259669-fod4xkd7 376 4 the the DT cord-259669-fod4xkd7 376 5 MoDC MoDC NNP cord-259669-fod4xkd7 376 6 model model NN cord-259669-fod4xkd7 376 7 has have VBZ cord-259669-fod4xkd7 376 8 a a DT cord-259669-fod4xkd7 376 9 number number NN cord-259669-fod4xkd7 376 10 of of IN cord-259669-fod4xkd7 376 11 advantages advantage NNS cord-259669-fod4xkd7 376 12 and and CC cord-259669-fod4xkd7 376 13 applicability applicability NN cord-259669-fod4xkd7 376 14 . . . cord-259669-fod4xkd7 377 1 Large large JJ cord-259669-fod4xkd7 377 2 numbers number NNS cord-259669-fod4xkd7 377 3 of of IN cord-259669-fod4xkd7 377 4 DC DC NNP cord-259669-fod4xkd7 377 5 can can MD cord-259669-fod4xkd7 377 6 be be VB cord-259669-fod4xkd7 377 7 generated generate VBN cord-259669-fod4xkd7 377 8 without without IN cord-259669-fod4xkd7 377 9 killing kill VBG cord-259669-fod4xkd7 377 10 the the DT cord-259669-fod4xkd7 377 11 animal animal NN cord-259669-fod4xkd7 377 12 . . . cord-259669-fod4xkd7 378 1 For for IN cord-259669-fod4xkd7 378 2 example example NN cord-259669-fod4xkd7 378 3 , , , cord-259669-fod4xkd7 378 4 a a DT cord-259669-fod4xkd7 378 5 typical typical JJ cord-259669-fod4xkd7 378 6 figure figure NN cord-259669-fod4xkd7 378 7 of of IN cord-259669-fod4xkd7 378 8 30 30 CD cord-259669-fod4xkd7 378 9 - - SYM cord-259669-fod4xkd7 378 10 70 70 CD cord-259669-fod4xkd7 378 11 million million CD cord-259669-fod4xkd7 378 12 DC DC NNP cord-259669-fod4xkd7 378 13 can can MD cord-259669-fod4xkd7 378 14 be be VB cord-259669-fod4xkd7 378 15 generated generate VBN cord-259669-fod4xkd7 378 16 using use VBG cord-259669-fod4xkd7 378 17 monocytes monocyte NNS cord-259669-fod4xkd7 378 18 isolated isolate VBN cord-259669-fod4xkd7 378 19 from from IN cord-259669-fod4xkd7 378 20 400 400 CD cord-259669-fod4xkd7 378 21 ml ml NNS cord-259669-fod4xkd7 378 22 of of IN cord-259669-fod4xkd7 378 23 blood blood NN cord-259669-fod4xkd7 378 24 . . . cord-259669-fod4xkd7 379 1 The the DT cord-259669-fod4xkd7 379 2 facility facility NN cord-259669-fod4xkd7 379 3 to to TO cord-259669-fod4xkd7 379 4 repeat repeat VB cord-259669-fod4xkd7 379 5 blood blood NN cord-259669-fod4xkd7 379 6 sampling sampling NN cord-259669-fod4xkd7 379 7 with with IN cord-259669-fod4xkd7 379 8 the the DT cord-259669-fod4xkd7 379 9 pig pig NN cord-259669-fod4xkd7 379 10 enables enable VBZ cord-259669-fod4xkd7 379 11 the the DT cord-259669-fod4xkd7 379 12 use use NN cord-259669-fod4xkd7 379 13 of of IN cord-259669-fod4xkd7 379 14 these these DT cord-259669-fod4xkd7 379 15 DC DC NNP cord-259669-fod4xkd7 379 16 in in IN cord-259669-fod4xkd7 379 17 antigen antigen NN cord-259669-fod4xkd7 379 18 presentation presentation NN cord-259669-fod4xkd7 379 19 assays assay NNS cord-259669-fod4xkd7 379 20 , , , cord-259669-fod4xkd7 379 21 to to TO cord-259669-fod4xkd7 379 22 monitor monitor VB cord-259669-fod4xkd7 379 23 autologous autologous JJ cord-259669-fod4xkd7 379 24 Tcell Tcell NNP cord-259669-fod4xkd7 379 25 responses response NNS cord-259669-fod4xkd7 379 26 in in IN cord-259669-fod4xkd7 379 27 immunization immunization NN cord-259669-fod4xkd7 379 28 experiments experiment NNS cord-259669-fod4xkd7 379 29 with with IN cord-259669-fod4xkd7 379 30 outbred outbred JJ cord-259669-fod4xkd7 379 31 animals animal NNS cord-259669-fod4xkd7 379 32 [ [ -LRB- cord-259669-fod4xkd7 379 33 113 113 CD cord-259669-fod4xkd7 379 34 ] ] -RRB- cord-259669-fod4xkd7 379 35 . . . cord-259669-fod4xkd7 380 1 Moreover moreover RB cord-259669-fod4xkd7 380 2 , , , cord-259669-fod4xkd7 380 3 with with IN cord-259669-fod4xkd7 380 4 the the DT cord-259669-fod4xkd7 380 5 MoDC modc NN cord-259669-fod4xkd7 380 6 being being NN cord-259669-fod4xkd7 380 7 in in IN cord-259669-fod4xkd7 380 8 an an DT cord-259669-fod4xkd7 380 9 immature immature JJ cord-259669-fod4xkd7 380 10 state state NN cord-259669-fod4xkd7 380 11 , , , cord-259669-fod4xkd7 380 12 another another DT cord-259669-fod4xkd7 380 13 advantage advantage NN cord-259669-fod4xkd7 380 14 is be VBZ cord-259669-fod4xkd7 380 15 the the DT cord-259669-fod4xkd7 380 16 possibility possibility NN cord-259669-fod4xkd7 380 17 to to TO cord-259669-fod4xkd7 380 18 study study VB cord-259669-fod4xkd7 380 19 DC DC NNP cord-259669-fod4xkd7 380 20 maturation maturation NN cord-259669-fod4xkd7 380 21 in in IN cord-259669-fod4xkd7 380 22 response response NN cord-259669-fod4xkd7 380 23 to to IN cord-259669-fod4xkd7 380 24 cytokines cytokine NNS cord-259669-fod4xkd7 380 25 , , , cord-259669-fod4xkd7 380 26 TLR TLR NNP cord-259669-fod4xkd7 380 27 ligands ligand NNS cord-259669-fod4xkd7 380 28 and and CC cord-259669-fod4xkd7 380 29 infections infection NNS cord-259669-fod4xkd7 380 30 . . . cord-259669-fod4xkd7 381 1 Considering consider VBG cord-259669-fod4xkd7 381 2 that that IN cord-259669-fod4xkd7 381 3 DC DC NNP cord-259669-fod4xkd7 381 4 are be VBP cord-259669-fod4xkd7 381 5 a a DT cord-259669-fod4xkd7 381 6 rare rare JJ cord-259669-fod4xkd7 381 7 cell cell NN cord-259669-fod4xkd7 381 8 type type NN cord-259669-fod4xkd7 381 9 within within IN cord-259669-fod4xkd7 381 10 the the DT cord-259669-fod4xkd7 381 11 leukocyte leukocyte NN cord-259669-fod4xkd7 381 12 populations population NNS cord-259669-fod4xkd7 381 13 , , , cord-259669-fod4xkd7 381 14 the the DT cord-259669-fod4xkd7 381 15 large large JJ cord-259669-fod4xkd7 381 16 size size NN cord-259669-fod4xkd7 381 17 of of IN cord-259669-fod4xkd7 381 18 the the DT cord-259669-fod4xkd7 381 19 pig pig NN cord-259669-fod4xkd7 381 20 , , , cord-259669-fod4xkd7 381 21 its -PRON- PRP$ cord-259669-fod4xkd7 381 22 lymphoid lymphoid JJ cord-259669-fod4xkd7 381 23 organs organ NNS cord-259669-fod4xkd7 381 24 and and CC cord-259669-fod4xkd7 381 25 the the DT cord-259669-fod4xkd7 381 26 availability availability NN cord-259669-fod4xkd7 381 27 of of IN cord-259669-fod4xkd7 381 28 larger large JJR cord-259669-fod4xkd7 381 29 volumes volume NNS cord-259669-fod4xkd7 381 30 of of IN cord-259669-fod4xkd7 381 31 blood blood NN cord-259669-fod4xkd7 381 32 together together RB cord-259669-fod4xkd7 381 33 with with IN cord-259669-fod4xkd7 381 34 repeated repeat VBN cord-259669-fod4xkd7 381 35 samplings sampling NNS cord-259669-fod4xkd7 381 36 offer offer VBP cord-259669-fod4xkd7 381 37 an an DT cord-259669-fod4xkd7 381 38 advantage advantage NN cord-259669-fod4xkd7 381 39 allowing allow VBG cord-259669-fod4xkd7 381 40 considerable considerable JJ cord-259669-fod4xkd7 381 41 immunological immunological JJ cord-259669-fod4xkd7 381 42 progress progress NN cord-259669-fod4xkd7 381 43 . . . cord-259669-fod4xkd7 382 1 In in IN cord-259669-fod4xkd7 382 2 addition addition NN cord-259669-fod4xkd7 382 3 to to IN cord-259669-fod4xkd7 382 4 this this DT cord-259669-fod4xkd7 382 5 facility facility NN cord-259669-fod4xkd7 382 6 of of IN cord-259669-fod4xkd7 382 7 recovering recover VBG cord-259669-fod4xkd7 382 8 large large JJ cord-259669-fod4xkd7 382 9 volumes volume NNS cord-259669-fod4xkd7 382 10 of of IN cord-259669-fod4xkd7 382 11 blood blood NN cord-259669-fod4xkd7 382 12 regularly regularly RB cord-259669-fod4xkd7 382 13 from from IN cord-259669-fod4xkd7 382 14 the the DT cord-259669-fod4xkd7 382 15 same same JJ cord-259669-fod4xkd7 382 16 animal animal NN cord-259669-fod4xkd7 382 17 , , , cord-259669-fod4xkd7 382 18 cannulation cannulation NN cord-259669-fod4xkd7 382 19 procedures procedure NNS cord-259669-fod4xkd7 382 20 for for IN cord-259669-fod4xkd7 382 21 porcine porcine JJ cord-259669-fod4xkd7 382 22 lymph lymph NN cord-259669-fod4xkd7 382 23 vessels vessel NNS cord-259669-fod4xkd7 382 24 at at IN cord-259669-fod4xkd7 382 25 both both CC cord-259669-fod4xkd7 382 26 peripheral peripheral JJ cord-259669-fod4xkd7 382 27 and and CC cord-259669-fod4xkd7 382 28 mucosal mucosal JJ cord-259669-fod4xkd7 382 29 sites site NNS cord-259669-fod4xkd7 382 30 are be VBP cord-259669-fod4xkd7 382 31 now now RB cord-259669-fod4xkd7 382 32 available available JJ cord-259669-fod4xkd7 382 33 . . . cord-259669-fod4xkd7 383 1 This this DT cord-259669-fod4xkd7 383 2 approach approach NN cord-259669-fod4xkd7 383 3 allows allow VBZ cord-259669-fod4xkd7 383 4 us -PRON- PRP cord-259669-fod4xkd7 383 5 the the DT cord-259669-fod4xkd7 383 6 much much RB cord-259669-fod4xkd7 383 7 sought seek VBD cord-259669-fod4xkd7 383 8 ability ability NN cord-259669-fod4xkd7 383 9 of of IN cord-259669-fod4xkd7 383 10 studying study VBG cord-259669-fod4xkd7 383 11 DC DC NNP cord-259669-fod4xkd7 383 12 migrating migrate VBG cord-259669-fod4xkd7 383 13 from from IN cord-259669-fod4xkd7 383 14 peripheral peripheral JJ cord-259669-fod4xkd7 383 15 sites site NNS cord-259669-fod4xkd7 383 16 over over IN cord-259669-fod4xkd7 383 17 periods period NNS cord-259669-fod4xkd7 383 18 of of IN cord-259669-fod4xkd7 383 19 several several JJ cord-259669-fod4xkd7 383 20 days day NNS cord-259669-fod4xkd7 383 21 [ [ -LRB- cord-259669-fod4xkd7 383 22 47 47 CD cord-259669-fod4xkd7 383 23 , , , cord-259669-fod4xkd7 383 24 56 56 CD cord-259669-fod4xkd7 383 25 ] ] -RRB- cord-259669-fod4xkd7 383 26 , , , cord-259669-fod4xkd7 383 27 a a DT cord-259669-fod4xkd7 383 28 procedure procedure NN cord-259669-fod4xkd7 383 29 not not RB cord-259669-fod4xkd7 383 30 possible possible JJ cord-259669-fod4xkd7 383 31 with with IN cord-259669-fod4xkd7 383 32 humans human NNS cord-259669-fod4xkd7 383 33 and and CC cord-259669-fod4xkd7 383 34 certainly certainly RB cord-259669-fod4xkd7 383 35 cumbersome cumbersome JJ cord-259669-fod4xkd7 383 36 with with IN cord-259669-fod4xkd7 383 37 mice mouse NNS cord-259669-fod4xkd7 383 38 considering consider VBG cord-259669-fod4xkd7 383 39 their -PRON- PRP$ cord-259669-fod4xkd7 383 40 size size NN cord-259669-fod4xkd7 383 41 and and CC cord-259669-fod4xkd7 383 42 the the DT cord-259669-fod4xkd7 383 43 quantities quantity NNS cord-259669-fod4xkd7 383 44 of of IN cord-259669-fod4xkd7 383 45 material material NN cord-259669-fod4xkd7 383 46 obtained obtain VBN cord-259669-fod4xkd7 383 47 . . . cord-259669-fod4xkd7 384 1 Moreover moreover RB cord-259669-fod4xkd7 384 2 , , , cord-259669-fod4xkd7 384 3 the the DT cord-259669-fod4xkd7 384 4 pig pig NN cord-259669-fod4xkd7 384 5 is be VBZ cord-259669-fod4xkd7 384 6 more more RBR cord-259669-fod4xkd7 384 7 closely closely RB cord-259669-fod4xkd7 384 8 related related JJ cord-259669-fod4xkd7 384 9 to to IN cord-259669-fod4xkd7 384 10 the the DT cord-259669-fod4xkd7 384 11 human human NN cord-259669-fod4xkd7 384 12 - - : cord-259669-fod4xkd7 384 13 both both CC cord-259669-fod4xkd7 384 14 genetically genetically RB cord-259669-fod4xkd7 384 15 and and CC cord-259669-fod4xkd7 384 16 physiologically physiologically RB cord-259669-fod4xkd7 384 17 - - HYPH cord-259669-fod4xkd7 384 18 when when WRB cord-259669-fod4xkd7 384 19 compared compare VBN cord-259669-fod4xkd7 384 20 to to IN cord-259669-fod4xkd7 384 21 mice mouse NNS cord-259669-fod4xkd7 384 22 . . . cord-259669-fod4xkd7 385 1 This this DT cord-259669-fod4xkd7 385 2 is be VBZ cord-259669-fod4xkd7 385 3 reflected reflect VBN cord-259669-fod4xkd7 385 4 by by IN cord-259669-fod4xkd7 385 5 immunological immunological JJ cord-259669-fod4xkd7 385 6 similarities similarity NNS cord-259669-fod4xkd7 385 7 such such JJ cord-259669-fod4xkd7 385 8 as as IN cord-259669-fod4xkd7 385 9 the the DT cord-259669-fod4xkd7 385 10 PRR PRR NNP cord-259669-fod4xkd7 385 11 and and CC cord-259669-fod4xkd7 385 12 their -PRON- PRP$ cord-259669-fod4xkd7 385 13 cellular cellular JJ cord-259669-fod4xkd7 385 14 distributions distribution NNS cord-259669-fod4xkd7 385 15 [ [ -LRB- cord-259669-fod4xkd7 385 16 58 58 CD cord-259669-fod4xkd7 385 17 , , , cord-259669-fod4xkd7 385 18 59 59 CD cord-259669-fod4xkd7 385 19 ] ] -RRB- cord-259669-fod4xkd7 385 20 . . . cord-259669-fod4xkd7 386 1 Finally finally RB cord-259669-fod4xkd7 386 2 , , , cord-259669-fod4xkd7 386 3 the the DT cord-259669-fod4xkd7 386 4 advantages advantage NNS cord-259669-fod4xkd7 386 5 which which WDT cord-259669-fod4xkd7 386 6 porcine porcine JJ cord-259669-fod4xkd7 386 7 immunology immunology NN cord-259669-fod4xkd7 386 8 has have VBZ cord-259669-fod4xkd7 386 9 to to TO cord-259669-fod4xkd7 386 10 offer offer VB cord-259669-fod4xkd7 386 11 have have VB cord-259669-fod4xkd7 386 12 gained gain VBN cord-259669-fod4xkd7 386 13 a a DT cord-259669-fod4xkd7 386 14 further further JJ cord-259669-fod4xkd7 386 15 boost boost NN cord-259669-fod4xkd7 386 16 with with IN cord-259669-fod4xkd7 386 17 the the DT cord-259669-fod4xkd7 386 18 advent advent NN cord-259669-fod4xkd7 386 19 of of IN cord-259669-fod4xkd7 386 20 novel novel JJ cord-259669-fod4xkd7 386 21 technologies technology NNS cord-259669-fod4xkd7 386 22 such such JJ cord-259669-fod4xkd7 386 23 as as IN cord-259669-fod4xkd7 386 24 RNA RNA NNP cord-259669-fod4xkd7 386 25 interference interference NN cord-259669-fod4xkd7 386 26 ( ( -LRB- cord-259669-fod4xkd7 386 27 RNAi RNAi NNP cord-259669-fod4xkd7 386 28 ) ) -RRB- cord-259669-fod4xkd7 386 29 [ [ -LRB- cord-259669-fod4xkd7 386 30 38 38 CD cord-259669-fod4xkd7 386 31 ] ] -RRB- cord-259669-fod4xkd7 386 32 , , , cord-259669-fod4xkd7 386 33 which which WDT cord-259669-fod4xkd7 386 34 can can MD cord-259669-fod4xkd7 386 35 be be VB cord-259669-fod4xkd7 386 36 combined combine VBN cord-259669-fod4xkd7 386 37 with with IN cord-259669-fod4xkd7 386 38 the the DT cord-259669-fod4xkd7 386 39 generation generation NN cord-259669-fod4xkd7 386 40 of of IN cord-259669-fod4xkd7 386 41 transgenic transgenic JJ cord-259669-fod4xkd7 386 42 pigs pig NNS cord-259669-fod4xkd7 386 43 [ [ -LRB- cord-259669-fod4xkd7 386 44 117 117 CD cord-259669-fod4xkd7 386 45 ] ] -RRB- cord-259669-fod4xkd7 386 46 . . . cord-259669-fod4xkd7 387 1 Localization localization NN cord-259669-fod4xkd7 387 2 of of IN cord-259669-fod4xkd7 387 3 distinct distinct JJ cord-259669-fod4xkd7 387 4 Peyer Peyer NNP cord-259669-fod4xkd7 387 5 's 's POS cord-259669-fod4xkd7 387 6 patch patch NN cord-259669-fod4xkd7 387 7 dendritic dendritic JJ cord-259669-fod4xkd7 387 8 cell cell NN cord-259669-fod4xkd7 387 9 subsets subset NNS cord-259669-fod4xkd7 387 10 and and CC cord-259669-fod4xkd7 387 11 their -PRON- PRP$ cord-259669-fod4xkd7 387 12 recruitment recruitment NN cord-259669-fod4xkd7 387 13 by by IN cord-259669-fod4xkd7 387 14 chemokines chemokine NNS cord-259669-fod4xkd7 387 15 macrophage macrophage NN cord-259669-fod4xkd7 387 16 inflammatory inflammatory JJ cord-259669-fod4xkd7 387 17 protein protein NN cord-259669-fod4xkd7 387 18 ( ( -LRB- cord-259669-fod4xkd7 387 19 MIP)-3alpha MIP)-3alpha NNPS cord-259669-fod4xkd7 387 20 , , , cord-259669-fod4xkd7 387 21 MIP-3beta mip-3beta NN cord-259669-fod4xkd7 387 22 , , , cord-259669-fod4xkd7 387 23 and and CC cord-259669-fod4xkd7 387 24 secondary secondary JJ cord-259669-fod4xkd7 387 25 lymphoid lymphoid JJ cord-259669-fod4xkd7 387 26 organ organ NN cord-259669-fod4xkd7 387 27 chemokine chemokine NN cord-259669-fod4xkd7 387 28 Myeloid Myeloid NNP cord-259669-fod4xkd7 387 29 C c NN cord-259669-fod4xkd7 387 30 - - HYPH cord-259669-fod4xkd7 387 31 type type NN cord-259669-fod4xkd7 387 32 lectins lectin NNS cord-259669-fod4xkd7 387 33 in in IN cord-259669-fod4xkd7 387 34 innate innate JJ cord-259669-fod4xkd7 387 35 immunity immunity NN cord-259669-fod4xkd7 387 36 Cooperation Cooperation NNP cord-259669-fod4xkd7 387 37 of of IN cord-259669-fod4xkd7 387 38 Toll Toll NNP cord-259669-fod4xkd7 387 39 - - HYPH cord-259669-fod4xkd7 387 40 like like JJ cord-259669-fod4xkd7 387 41 receptor receptor NN cord-259669-fod4xkd7 387 42 signals signal NNS cord-259669-fod4xkd7 387 43 in in IN cord-259669-fod4xkd7 387 44 innate innate JJ cord-259669-fod4xkd7 387 45 immune immune JJ cord-259669-fod4xkd7 387 46 defence defence NN cord-259669-fod4xkd7 387 47 Signaling signal VBG cord-259669-fod4xkd7 387 48 pathways pathway NNS cord-259669-fod4xkd7 387 49 downstream downstream RB cord-259669-fod4xkd7 387 50 of of IN cord-259669-fod4xkd7 387 51 patternrecognition patternrecognition NN cord-259669-fod4xkd7 387 52 receptors receptor NNS cord-259669-fod4xkd7 387 53 and and CC cord-259669-fod4xkd7 387 54 their -PRON- PRP$ cord-259669-fod4xkd7 387 55 cross cross NN cord-259669-fod4xkd7 387 56 talk talk NN cord-259669-fod4xkd7 387 57 Dendritic Dendritic NNP cord-259669-fod4xkd7 387 58 cells cell NNS cord-259669-fod4xkd7 387 59 interact interact VBP cord-259669-fod4xkd7 387 60 directly directly RB cord-259669-fod4xkd7 387 61 with with IN cord-259669-fod4xkd7 387 62 naive naive JJ cord-259669-fod4xkd7 387 63 B b NN cord-259669-fod4xkd7 387 64 lymphocytes lymphocyte NNS cord-259669-fod4xkd7 387 65 to to TO cord-259669-fod4xkd7 387 66 transfer transfer VB cord-259669-fod4xkd7 387 67 antigen antigen NN cord-259669-fod4xkd7 387 68 and and CC cord-259669-fod4xkd7 387 69 initiate initiate VB cord-259669-fod4xkd7 387 70 class class NN cord-259669-fod4xkd7 387 71 switching switching NN cord-259669-fod4xkd7 387 72 in in IN cord-259669-fod4xkd7 387 73 a a DT cord-259669-fod4xkd7 387 74 primary primary JJ cord-259669-fod4xkd7 387 75 T t NN cord-259669-fod4xkd7 387 76 - - HYPH cord-259669-fod4xkd7 387 77 dependent dependent JJ cord-259669-fod4xkd7 387 78 response response NN cord-259669-fod4xkd7 387 79 Critical critical JJ cord-259669-fod4xkd7 387 80 role role NN cord-259669-fod4xkd7 387 81 of of IN cord-259669-fod4xkd7 387 82 ITIM ITIM NNP cord-259669-fod4xkd7 387 83 - - HYPH cord-259669-fod4xkd7 387 84 bearing bear VBG cord-259669-fod4xkd7 387 85 FcgammaR FcgammaR NNP cord-259669-fod4xkd7 387 86 on on IN cord-259669-fod4xkd7 387 87 DCs dc NNS cord-259669-fod4xkd7 387 88 in in IN cord-259669-fod4xkd7 387 89 the the DT cord-259669-fod4xkd7 387 90 capture capture NN cord-259669-fod4xkd7 387 91 and and CC cord-259669-fod4xkd7 387 92 presentation presentation NN cord-259669-fod4xkd7 387 93 of of IN cord-259669-fod4xkd7 387 94 native native JJ cord-259669-fod4xkd7 387 95 antigen antigen NN cord-259669-fod4xkd7 387 96 to to IN cord-259669-fod4xkd7 387 97 B b NN cord-259669-fod4xkd7 387 98 cells cell NNS cord-259669-fod4xkd7 387 99 Cell cell NN cord-259669-fod4xkd7 387 100 surface surface NN cord-259669-fod4xkd7 387 101 recycling recycling NN cord-259669-fod4xkd7 387 102 of of IN cord-259669-fod4xkd7 387 103 internalized internalize VBN cord-259669-fod4xkd7 387 104 antigen antigen NN cord-259669-fod4xkd7 387 105 permits permit VBZ cord-259669-fod4xkd7 387 106 dendritic dendritic JJ cord-259669-fod4xkd7 387 107 cell cell NN cord-259669-fod4xkd7 387 108 priming priming NN cord-259669-fod4xkd7 387 109 of of IN cord-259669-fod4xkd7 387 110 B b NN cord-259669-fod4xkd7 387 111 cells cell NNS cord-259669-fod4xkd7 387 112 Immunobiology Immunobiology NNP cord-259669-fod4xkd7 387 113 of of IN cord-259669-fod4xkd7 387 114 dendritic dendritic JJ cord-259669-fod4xkd7 387 115 cells cell NNS cord-259669-fod4xkd7 387 116 Dendritic dendritic JJ cord-259669-fod4xkd7 387 117 cells cell NNS cord-259669-fod4xkd7 387 118 , , , cord-259669-fod4xkd7 387 119 BAFF BAFF NNP cord-259669-fod4xkd7 387 120 , , , cord-259669-fod4xkd7 387 121 and and CC cord-259669-fod4xkd7 387 122 APRIL APRIL NNP cord-259669-fod4xkd7 387 123 : : : cord-259669-fod4xkd7 388 1 innate innate JJ cord-259669-fod4xkd7 388 2 players player NNS cord-259669-fod4xkd7 388 3 in in IN cord-259669-fod4xkd7 388 4 adaptive adaptive JJ cord-259669-fod4xkd7 388 5 antibody antibody NN cord-259669-fod4xkd7 388 6 responses response NNS cord-259669-fod4xkd7 388 7 Pathogen Pathogen NNP cord-259669-fod4xkd7 388 8 - - HYPH cord-259669-fod4xkd7 388 9 induced induce VBN cord-259669-fod4xkd7 388 10 private private JJ cord-259669-fod4xkd7 388 11 conversations conversation NNS cord-259669-fod4xkd7 388 12 between between IN cord-259669-fod4xkd7 388 13 natural natural JJ cord-259669-fod4xkd7 388 14 killer killer NN cord-259669-fod4xkd7 388 15 and and CC cord-259669-fod4xkd7 388 16 dendritic dendritic JJ cord-259669-fod4xkd7 388 17 cells cell NNS cord-259669-fod4xkd7 389 1 Close close JJ cord-259669-fod4xkd7 389 2 encounters encounter NNS cord-259669-fod4xkd7 389 3 of of IN cord-259669-fod4xkd7 389 4 different different JJ cord-259669-fod4xkd7 389 5 kinds kind NNS cord-259669-fod4xkd7 389 6 : : : cord-259669-fod4xkd7 389 7 dendritic dendritic JJ cord-259669-fod4xkd7 389 8 cells cell NNS cord-259669-fod4xkd7 389 9 and and CC cord-259669-fod4xkd7 389 10 NK NK NNP cord-259669-fod4xkd7 389 11 cells cell NNS cord-259669-fod4xkd7 389 12 take take VBP cord-259669-fod4xkd7 389 13 centre centre NN cord-259669-fod4xkd7 389 14 stage stage NN cord-259669-fod4xkd7 390 1 Two two CD cord-259669-fod4xkd7 390 2 way way NN cord-259669-fod4xkd7 390 3 communication communication NN cord-259669-fod4xkd7 390 4 between between IN cord-259669-fod4xkd7 390 5 neutrophils neutrophil NNS cord-259669-fod4xkd7 390 6 and and CC cord-259669-fod4xkd7 390 7 dendritic dendritic JJ cord-259669-fod4xkd7 390 8 cells cell NNS cord-259669-fod4xkd7 390 9 IPC IPC NNP cord-259669-fod4xkd7 390 10 : : : cord-259669-fod4xkd7 390 11 professional professional JJ cord-259669-fod4xkd7 390 12 type type NN cord-259669-fod4xkd7 390 13 1 1 CD cord-259669-fod4xkd7 390 14 interferon interferon NN cord-259669-fod4xkd7 390 15 - - HYPH cord-259669-fod4xkd7 390 16 producing produce VBG cord-259669-fod4xkd7 390 17 cells cell NNS cord-259669-fod4xkd7 390 18 and and CC cord-259669-fod4xkd7 390 19 plasmacytoid plasmacytoid NNP cord-259669-fod4xkd7 390 20 dendritic dendritic JJ cord-259669-fod4xkd7 390 21 cell cell NN cord-259669-fod4xkd7 390 22 precursors precursor NNS cord-259669-fod4xkd7 390 23 Human human JJ cord-259669-fod4xkd7 390 24 natural natural JJ cord-259669-fod4xkd7 390 25 interferon interferon NN cord-259669-fod4xkd7 390 26 - - HYPH cord-259669-fod4xkd7 390 27 alpha alpha NN cord-259669-fod4xkd7 390 28 producing producing NN cord-259669-fod4xkd7 390 29 cells cell NNS cord-259669-fod4xkd7 391 1 Direct direct JJ cord-259669-fod4xkd7 391 2 proteasome proteasome NN cord-259669-fod4xkd7 391 3 - - HYPH cord-259669-fod4xkd7 391 4 independent independent JJ cord-259669-fod4xkd7 391 5 cross cross JJ cord-259669-fod4xkd7 391 6 - - NN cord-259669-fod4xkd7 391 7 presentation presentation NN cord-259669-fod4xkd7 391 8 of of IN cord-259669-fod4xkd7 391 9 viral viral JJ cord-259669-fod4xkd7 391 10 antigen antigen NN cord-259669-fod4xkd7 391 11 by by IN cord-259669-fod4xkd7 391 12 plasmacytoid plasmacytoid NNP cord-259669-fod4xkd7 391 13 dendritic dendritic JJ cord-259669-fod4xkd7 391 14 cells cell NNS cord-259669-fod4xkd7 391 15 on on IN cord-259669-fod4xkd7 391 16 major major JJ cord-259669-fod4xkd7 391 17 histocompatibility histocompatibility NN cord-259669-fod4xkd7 391 18 complex complex JJ cord-259669-fod4xkd7 391 19 class class NN cord-259669-fod4xkd7 392 1 I -PRON- PRP cord-259669-fod4xkd7 392 2 Dendritic dendritic JJ cord-259669-fod4xkd7 392 3 cell cell NN cord-259669-fod4xkd7 392 4 preactivation preactivation NN cord-259669-fod4xkd7 392 5 impairs impair VBZ cord-259669-fod4xkd7 392 6 MHC MHC NNP cord-259669-fod4xkd7 392 7 class class NN cord-259669-fod4xkd7 392 8 II II NNP cord-259669-fod4xkd7 392 9 presentation presentation NN cord-259669-fod4xkd7 392 10 of of IN cord-259669-fod4xkd7 392 11 vaccines vaccine NNS cord-259669-fod4xkd7 392 12 and and CC cord-259669-fod4xkd7 392 13 endogenous endogenous JJ cord-259669-fod4xkd7 392 14 viral viral JJ cord-259669-fod4xkd7 392 15 antigens antigen NNS cord-259669-fod4xkd7 392 16 Intrinsic intrinsic JJ cord-259669-fod4xkd7 392 17 and and CC cord-259669-fod4xkd7 392 18 cooperative cooperative JJ cord-259669-fod4xkd7 392 19 antigenpresenting antigenpresenting NN cord-259669-fod4xkd7 392 20 functions function NNS cord-259669-fod4xkd7 392 21 of of IN cord-259669-fod4xkd7 392 22 dendritic dendritic JJ cord-259669-fod4xkd7 392 23 - - HYPH cord-259669-fod4xkd7 392 24 cell cell NN cord-259669-fod4xkd7 392 25 subsets subset NNS cord-259669-fod4xkd7 392 26 in in IN cord-259669-fod4xkd7 392 27 vivo vivo NNP cord-259669-fod4xkd7 392 28 Enhanced enhanced JJ cord-259669-fod4xkd7 392 29 dendritic dendritic JJ cord-259669-fod4xkd7 392 30 cell cell NN cord-259669-fod4xkd7 392 31 antigen antigen NN cord-259669-fod4xkd7 392 32 capture capture NN cord-259669-fod4xkd7 392 33 via via IN cord-259669-fod4xkd7 392 34 Toll toll NN cord-259669-fod4xkd7 392 35 - - HYPH cord-259669-fod4xkd7 392 36 like like JJ cord-259669-fod4xkd7 392 37 receptor receptor NN cord-259669-fod4xkd7 392 38 - - HYPH cord-259669-fod4xkd7 392 39 induced induce VBN cord-259669-fod4xkd7 392 40 actin actin NN cord-259669-fod4xkd7 392 41 remodeling remodel VBG cord-259669-fod4xkd7 392 42 Dendritic dendritic JJ cord-259669-fod4xkd7 392 43 cells cell NNS cord-259669-fod4xkd7 392 44 in in IN cord-259669-fod4xkd7 392 45 a a DT cord-259669-fod4xkd7 392 46 mature mature JJ cord-259669-fod4xkd7 392 47 age age NN cord-259669-fod4xkd7 392 48 Characterization characterization NN cord-259669-fod4xkd7 392 49 of of IN cord-259669-fod4xkd7 392 50 swine swine NN cord-259669-fod4xkd7 392 51 leukocyte leukocyte NN cord-259669-fod4xkd7 392 52 differentiation differentiation NN cord-259669-fod4xkd7 392 53 antigens antigen VBZ cord-259669-fod4xkd7 392 54 Characterization characterization NN cord-259669-fod4xkd7 392 55 of of IN cord-259669-fod4xkd7 392 56 swine swine NN cord-259669-fod4xkd7 392 57 leukocyte leukocyte NN cord-259669-fod4xkd7 392 58 differentiation differentiation NN cord-259669-fod4xkd7 392 59 antigens antigen NNS cord-259669-fod4xkd7 392 60 Summary Summary NNP cord-259669-fod4xkd7 392 61 of of IN cord-259669-fod4xkd7 392 62 the the DT cord-259669-fod4xkd7 392 63 first first JJ cord-259669-fod4xkd7 392 64 round round JJ cord-259669-fod4xkd7 392 65 analyses analysis NNS cord-259669-fod4xkd7 392 66 of of IN cord-259669-fod4xkd7 392 67 the the DT cord-259669-fod4xkd7 392 68 Third Third NNP cord-259669-fod4xkd7 392 69 International International NNP cord-259669-fod4xkd7 392 70 Workshop Workshop NNP cord-259669-fod4xkd7 392 71 on on IN cord-259669-fod4xkd7 392 72 Swine Swine NNP cord-259669-fod4xkd7 392 73 Leukocyte Leukocyte NNP cord-259669-fod4xkd7 392 74 Differentiation differentiation NN cord-259669-fod4xkd7 392 75 Antigens Antigens NNP cord-259669-fod4xkd7 392 76 Porcine porcine JJ cord-259669-fod4xkd7 392 77 dendritic dendritic JJ cord-259669-fod4xkd7 392 78 cells cell NNS cord-259669-fod4xkd7 392 79 generated generate VBN cord-259669-fod4xkd7 392 80 in in IN cord-259669-fod4xkd7 392 81 vitro vitro FW cord-259669-fod4xkd7 392 82 : : : cord-259669-fod4xkd7 392 83 morphological morphological JJ cord-259669-fod4xkd7 392 84 , , , cord-259669-fod4xkd7 392 85 phenotypic phenotypic JJ cord-259669-fod4xkd7 392 86 and and CC cord-259669-fod4xkd7 392 87 functional functional JJ cord-259669-fod4xkd7 392 88 properties property NNS cord-259669-fod4xkd7 393 1 Functional functional JJ cord-259669-fod4xkd7 393 2 and and CC cord-259669-fod4xkd7 393 3 phenotypic phenotypic JJ cord-259669-fod4xkd7 393 4 characterization characterization NN cord-259669-fod4xkd7 393 5 of of IN cord-259669-fod4xkd7 393 6 distinct distinct JJ cord-259669-fod4xkd7 393 7 porcine porcine JJ cord-259669-fod4xkd7 393 8 dendritic dendritic JJ cord-259669-fod4xkd7 393 9 cells cell NNS cord-259669-fod4xkd7 393 10 derived derive VBN cord-259669-fod4xkd7 393 11 from from IN cord-259669-fod4xkd7 393 12 peripheral peripheral JJ cord-259669-fod4xkd7 393 13 blood blood NN cord-259669-fod4xkd7 393 14 monocytes monocyte NNS cord-259669-fod4xkd7 393 15 Fibrocytes Fibrocytes NNPS cord-259669-fod4xkd7 393 16 are be VBP cord-259669-fod4xkd7 393 17 potent potent JJ cord-259669-fod4xkd7 393 18 stimulators stimulator NNS cord-259669-fod4xkd7 393 19 of of IN cord-259669-fod4xkd7 393 20 anti anti JJ cord-259669-fod4xkd7 393 21 - - JJ cord-259669-fod4xkd7 393 22 virus virus JJ cord-259669-fod4xkd7 393 23 cytotoxic cytotoxic JJ cord-259669-fod4xkd7 393 24 T t NN cord-259669-fod4xkd7 393 25 cells cell NNS cord-259669-fod4xkd7 393 26 Characterisation Characterisation NNP cord-259669-fod4xkd7 393 27 of of IN cord-259669-fod4xkd7 393 28 porcine porcine JJ cord-259669-fod4xkd7 393 29 monocyte monocyte NN cord-259669-fod4xkd7 393 30 - - HYPH cord-259669-fod4xkd7 393 31 derived derive VBN cord-259669-fod4xkd7 393 32 dendritic dendritic JJ cord-259669-fod4xkd7 393 33 cells cell NNS cord-259669-fod4xkd7 393 34 according accord VBG cord-259669-fod4xkd7 393 35 to to IN cord-259669-fod4xkd7 393 36 their -PRON- PRP$ cord-259669-fod4xkd7 393 37 cytokine cytokine NN cord-259669-fod4xkd7 393 38 profile profile NN cord-259669-fod4xkd7 393 39 Toll toll NN cord-259669-fod4xkd7 393 40 - - HYPH cord-259669-fod4xkd7 393 41 like like JJ cord-259669-fod4xkd7 393 42 receptor receptor NN cord-259669-fod4xkd7 393 43 , , , cord-259669-fod4xkd7 393 44 MHC MHC NNP cord-259669-fod4xkd7 393 45 II II NNP cord-259669-fod4xkd7 393 46 , , , cord-259669-fod4xkd7 393 47 B7 b7 NN cord-259669-fod4xkd7 393 48 and and CC cord-259669-fod4xkd7 393 49 cytokine cytokine JJ cord-259669-fod4xkd7 393 50 expression expression NN cord-259669-fod4xkd7 393 51 by by IN cord-259669-fod4xkd7 393 52 porcine porcine JJ cord-259669-fod4xkd7 393 53 monocytes monocyte NNS cord-259669-fod4xkd7 393 54 and and CC cord-259669-fod4xkd7 393 55 monocytederived monocytederived JJ cord-259669-fod4xkd7 393 56 dendritic dendritic JJ cord-259669-fod4xkd7 393 57 cells cell NNS cord-259669-fod4xkd7 393 58 in in IN cord-259669-fod4xkd7 393 59 response response NN cord-259669-fod4xkd7 393 60 to to IN cord-259669-fod4xkd7 393 61 microbial microbial JJ cord-259669-fod4xkd7 393 62 pathogenassociated pathogenassociated JJ cord-259669-fod4xkd7 393 63 molecular molecular JJ cord-259669-fod4xkd7 393 64 patterns pattern NNS cord-259669-fod4xkd7 394 1 IL-13 IL-13 NNP cord-259669-fod4xkd7 394 2 replaces replace VBZ cord-259669-fod4xkd7 394 3 IL-4 IL-4 NNP cord-259669-fod4xkd7 394 4 in in IN cord-259669-fod4xkd7 394 5 development development NN cord-259669-fod4xkd7 394 6 of of IN cord-259669-fod4xkd7 394 7 monocyte monocyte NNP cord-259669-fod4xkd7 394 8 derived derive VBN cord-259669-fod4xkd7 394 9 dendritic dendritic JJ cord-259669-fod4xkd7 394 10 cells cell NNS cord-259669-fod4xkd7 394 11 ( ( -LRB- cord-259669-fod4xkd7 394 12 MoDC MoDC NNP cord-259669-fod4xkd7 394 13 ) ) -RRB- cord-259669-fod4xkd7 394 14 of of IN cord-259669-fod4xkd7 394 15 swine swine NN cord-259669-fod4xkd7 394 16 Differentiation differentiation NN cord-259669-fod4xkd7 394 17 of of IN cord-259669-fod4xkd7 394 18 porcine porcine JJ cord-259669-fod4xkd7 394 19 dendritic dendritic JJ cord-259669-fod4xkd7 394 20 cells cell NNS cord-259669-fod4xkd7 394 21 by by IN cord-259669-fod4xkd7 394 22 granulocytemacrophage granulocytemacrophage NN cord-259669-fod4xkd7 394 23 colony colony NN cord-259669-fod4xkd7 394 24 - - HYPH cord-259669-fod4xkd7 394 25 stimulating stimulate VBG cord-259669-fod4xkd7 394 26 factor factor NN cord-259669-fod4xkd7 394 27 expressed express VBN cord-259669-fod4xkd7 394 28 in in IN cord-259669-fod4xkd7 394 29 Pichia Pichia NNP cord-259669-fod4xkd7 394 30 pastoris pastoris NN cord-259669-fod4xkd7 395 1 In in IN cord-259669-fod4xkd7 395 2 vitro vitro FW cord-259669-fod4xkd7 395 3 differentiation differentiation NN cord-259669-fod4xkd7 395 4 of of IN cord-259669-fod4xkd7 395 5 porcine porcine JJ cord-259669-fod4xkd7 395 6 blood blood NN cord-259669-fod4xkd7 395 7 CD163 CD163 NNP cord-259669-fod4xkd7 395 8 À à NN cord-259669-fod4xkd7 395 9 and and CC cord-259669-fod4xkd7 395 10 CD163 CD163 NNP cord-259669-fod4xkd7 395 11 + + CC cord-259669-fod4xkd7 395 12 monocytes monocyte VBZ cord-259669-fod4xkd7 395 13 into into IN cord-259669-fod4xkd7 395 14 functional functional JJ cord-259669-fod4xkd7 395 15 dendritic dendritic JJ cord-259669-fod4xkd7 395 16 cells cell NNS cord-259669-fod4xkd7 395 17 Dendritic dendritic JJ cord-259669-fod4xkd7 395 18 cells cell NNS cord-259669-fod4xkd7 395 19 in in IN cord-259669-fod4xkd7 395 20 different different JJ cord-259669-fod4xkd7 395 21 animal animal NN cord-259669-fod4xkd7 395 22 species specie NNS cord-259669-fod4xkd7 395 23 : : : cord-259669-fod4xkd7 395 24 an an DT cord-259669-fod4xkd7 395 25 overview overview NN cord-259669-fod4xkd7 395 26 A a DT cord-259669-fod4xkd7 395 27 porcine porcine JJ cord-259669-fod4xkd7 395 28 cell cell NN cord-259669-fod4xkd7 395 29 surface surface NN cord-259669-fod4xkd7 395 30 receptor receptor NN cord-259669-fod4xkd7 395 31 identified identify VBN cord-259669-fod4xkd7 395 32 by by IN cord-259669-fod4xkd7 395 33 monoclonal monoclonal JJ cord-259669-fod4xkd7 395 34 antibodies antibody NNS cord-259669-fod4xkd7 395 35 to to IN cord-259669-fod4xkd7 395 36 SWC3 SWC3 NNP cord-259669-fod4xkd7 395 37 is be VBZ cord-259669-fod4xkd7 395 38 a a DT cord-259669-fod4xkd7 395 39 member member NN cord-259669-fod4xkd7 395 40 of of IN cord-259669-fod4xkd7 395 41 the the DT cord-259669-fod4xkd7 395 42 signal signal JJ cord-259669-fod4xkd7 395 43 regulatory regulatory JJ cord-259669-fod4xkd7 395 44 protein protein NN cord-259669-fod4xkd7 395 45 family family NN cord-259669-fod4xkd7 395 46 and and CC cord-259669-fod4xkd7 395 47 associates associate NNS cord-259669-fod4xkd7 395 48 with with IN cord-259669-fod4xkd7 395 49 protein protein NN cord-259669-fod4xkd7 395 50 - - HYPH cord-259669-fod4xkd7 395 51 tyrosine tyrosine NN cord-259669-fod4xkd7 395 52 phosphatase phosphatase NN cord-259669-fod4xkd7 395 53 SHP-1 SHP-1 NNP cord-259669-fod4xkd7 395 54 Porcine porcine JJ cord-259669-fod4xkd7 395 55 bone bone NN cord-259669-fod4xkd7 395 56 marrow marrow NN cord-259669-fod4xkd7 395 57 myeloid myeloid NN cord-259669-fod4xkd7 395 58 cells cell NNS cord-259669-fod4xkd7 395 59 : : : cord-259669-fod4xkd7 395 60 phenotype phenotype NN cord-259669-fod4xkd7 395 61 and and CC cord-259669-fod4xkd7 395 62 adhesion adhesion NN cord-259669-fod4xkd7 395 63 molecule molecule NN cord-259669-fod4xkd7 395 64 expression expression NN cord-259669-fod4xkd7 395 65 Cholera cholera NN cord-259669-fod4xkd7 395 66 toxin toxin NN cord-259669-fod4xkd7 395 67 promotes promote VBZ cord-259669-fod4xkd7 395 68 the the DT cord-259669-fod4xkd7 395 69 generation generation NN cord-259669-fod4xkd7 395 70 of of IN cord-259669-fod4xkd7 395 71 semi semi JJ cord-259669-fod4xkd7 395 72 - - JJ cord-259669-fod4xkd7 395 73 mature mature JJ cord-259669-fod4xkd7 395 74 porcine porcine JJ cord-259669-fod4xkd7 395 75 monocyte monocyte NN cord-259669-fod4xkd7 395 76 - - HYPH cord-259669-fod4xkd7 395 77 derived derive VBN cord-259669-fod4xkd7 395 78 dendritic dendritic JJ cord-259669-fod4xkd7 395 79 cells cell NNS cord-259669-fod4xkd7 395 80 that that WDT cord-259669-fod4xkd7 395 81 are be VBP cord-259669-fod4xkd7 395 82 unable unable JJ cord-259669-fod4xkd7 395 83 to to TO cord-259669-fod4xkd7 395 84 stimulate stimulate VB cord-259669-fod4xkd7 395 85 T t NN cord-259669-fod4xkd7 395 86 cells cell NNS cord-259669-fod4xkd7 395 87 Efficacy Efficacy NNP cord-259669-fod4xkd7 395 88 and and CC cord-259669-fod4xkd7 395 89 functionality functionality NN cord-259669-fod4xkd7 395 90 of of IN cord-259669-fod4xkd7 395 91 lipoprotein lipoprotein NNP cord-259669-fod4xkd7 395 92 OprI OprI NNP cord-259669-fod4xkd7 395 93 from from IN cord-259669-fod4xkd7 395 94 Pseudomonas Pseudomonas NNP cord-259669-fod4xkd7 395 95 aeruginosa aeruginosa NN cord-259669-fod4xkd7 395 96 as as IN cord-259669-fod4xkd7 395 97 adjuvant adjuvant JJ cord-259669-fod4xkd7 395 98 for for IN cord-259669-fod4xkd7 395 99 a a DT cord-259669-fod4xkd7 395 100 subunit subunit JJ cord-259669-fod4xkd7 395 101 vaccine vaccine NN cord-259669-fod4xkd7 395 102 against against IN cord-259669-fod4xkd7 395 103 classical classical JJ cord-259669-fod4xkd7 395 104 swine swine NN cord-259669-fod4xkd7 395 105 fever fever NN cord-259669-fod4xkd7 395 106 Double double RB cord-259669-fod4xkd7 395 107 - - HYPH cord-259669-fod4xkd7 395 108 stranded strand VBN cord-259669-fod4xkd7 395 109 secondary secondary JJ cord-259669-fod4xkd7 395 110 structures structure NNS cord-259669-fod4xkd7 395 111 on on IN cord-259669-fod4xkd7 395 112 mRNA mRNA NNP cord-259669-fod4xkd7 396 1 induce induce VB cord-259669-fod4xkd7 396 2 type type NN cord-259669-fod4xkd7 397 1 I -PRON- PRP cord-259669-fod4xkd7 398 1 interferon interferon NNP cord-259669-fod4xkd7 399 1 ( ( -LRB- cord-259669-fod4xkd7 399 2 IFN IFN NNP cord-259669-fod4xkd7 399 3 alpha alpha NN cord-259669-fod4xkd7 399 4 / / SYM cord-259669-fod4xkd7 399 5 beta beta NN cord-259669-fod4xkd7 399 6 ) ) -RRB- cord-259669-fod4xkd7 399 7 production production NN cord-259669-fod4xkd7 399 8 and and CC cord-259669-fod4xkd7 399 9 maturation maturation NN cord-259669-fod4xkd7 399 10 of of IN cord-259669-fod4xkd7 399 11 mRNA mrna NN cord-259669-fod4xkd7 399 12 - - HYPH cord-259669-fod4xkd7 399 13 transfected transfecte VBN cord-259669-fod4xkd7 399 14 monocytederived monocytederived JJ cord-259669-fod4xkd7 399 15 dendritic dendritic JJ cord-259669-fod4xkd7 399 16 cells cell NNS cord-259669-fod4xkd7 399 17 C C NNP cord-259669-fod4xkd7 399 18 - - HYPH cord-259669-fod4xkd7 399 19 kit kit NN cord-259669-fod4xkd7 399 20 positive positive JJ cord-259669-fod4xkd7 399 21 porcine porcine JJ cord-259669-fod4xkd7 399 22 bone bone NN cord-259669-fod4xkd7 399 23 marrow marrow NN cord-259669-fod4xkd7 399 24 progenitor progenitor NN cord-259669-fod4xkd7 399 25 cells cell NNS cord-259669-fod4xkd7 399 26 identified identify VBN cord-259669-fod4xkd7 399 27 and and CC cord-259669-fod4xkd7 399 28 enriched enrich VBN cord-259669-fod4xkd7 399 29 using use VBG cord-259669-fod4xkd7 399 30 recombinant recombinant JJ cord-259669-fod4xkd7 399 31 stem stem NN cord-259669-fod4xkd7 399 32 cell cell NN cord-259669-fod4xkd7 399 33 factor factor NN cord-259669-fod4xkd7 399 34 Summerfield Summerfield NNP cord-259669-fod4xkd7 399 35 A. A. NNP cord-259669-fod4xkd7 399 36 Toll Toll NNP cord-259669-fod4xkd7 399 37 - - HYPH cord-259669-fod4xkd7 399 38 like like JJ cord-259669-fod4xkd7 399 39 receptor receptor NN cord-259669-fod4xkd7 399 40 7 7 CD cord-259669-fod4xkd7 399 41 and and CC cord-259669-fod4xkd7 399 42 MyD88 myd88 JJ cord-259669-fod4xkd7 399 43 knockdown knockdown NN cord-259669-fod4xkd7 399 44 by by IN cord-259669-fod4xkd7 399 45 lentivirus lentivirus NN cord-259669-fod4xkd7 399 46 - - HYPH cord-259669-fod4xkd7 399 47 mediated mediate VBN cord-259669-fod4xkd7 399 48 RNA RNA NNP cord-259669-fod4xkd7 399 49 interference interference NN cord-259669-fod4xkd7 399 50 to to IN cord-259669-fod4xkd7 399 51 porcine porcine JJ cord-259669-fod4xkd7 399 52 dendritic dendritic JJ cord-259669-fod4xkd7 399 53 cell cell NN cord-259669-fod4xkd7 399 54 subsets subset NNS cord-259669-fod4xkd7 399 55 Identification Identification NNP cord-259669-fod4xkd7 399 56 of of IN cord-259669-fod4xkd7 399 57 clonogenic clonogenic NNP cord-259669-fod4xkd7 399 58 common common NNP cord-259669-fod4xkd7 399 59 Flt3 Flt3 NNP cord-259669-fod4xkd7 399 60 + + CC cord-259669-fod4xkd7 399 61 M M NNP cord-259669-fod4xkd7 399 62 - - HYPH cord-259669-fod4xkd7 399 63 CSFR CSFR NNP cord-259669-fod4xkd7 399 64 + + CC cord-259669-fod4xkd7 399 65 plasmacytoid plasmacytoid NN cord-259669-fod4xkd7 399 66 and and CC cord-259669-fod4xkd7 399 67 conventional conventional JJ cord-259669-fod4xkd7 399 68 dendritic dendritic JJ cord-259669-fod4xkd7 399 69 cell cell NN cord-259669-fod4xkd7 399 70 progenitors progenitor NNS cord-259669-fod4xkd7 399 71 in in IN cord-259669-fod4xkd7 399 72 mouse mouse NN cord-259669-fod4xkd7 399 73 bone bone NN cord-259669-fod4xkd7 399 74 marrow marrow NN cord-259669-fod4xkd7 399 75 Porcine porcine JJ cord-259669-fod4xkd7 399 76 peripheral peripheral JJ cord-259669-fod4xkd7 399 77 blood blood NN cord-259669-fod4xkd7 399 78 dendritic dendritic JJ cord-259669-fod4xkd7 399 79 cells cell NNS cord-259669-fod4xkd7 399 80 and and CC cord-259669-fod4xkd7 399 81 natural natural JJ cord-259669-fod4xkd7 399 82 interferon interferon NN cord-259669-fod4xkd7 399 83 - - HYPH cord-259669-fod4xkd7 399 84 producing produce VBG cord-259669-fod4xkd7 399 85 cells cell NNS cord-259669-fod4xkd7 399 86 Essential essential JJ cord-259669-fod4xkd7 399 87 role role NN cord-259669-fod4xkd7 399 88 of of IN cord-259669-fod4xkd7 399 89 antigen antigen NN cord-259669-fod4xkd7 399 90 - - HYPH cord-259669-fod4xkd7 399 91 presenting present VBG cord-259669-fod4xkd7 399 92 cell cell NN cord-259669-fod4xkd7 399 93 - - HYPH cord-259669-fod4xkd7 399 94 derived derive VBN cord-259669-fod4xkd7 399 95 BAFF BAFF NNP cord-259669-fod4xkd7 399 96 for for IN cord-259669-fod4xkd7 399 97 antibody antibody NN cord-259669-fod4xkd7 399 98 responses response NNS cord-259669-fod4xkd7 400 1 Immunological immunological JJ cord-259669-fod4xkd7 400 2 properties property NNS cord-259669-fod4xkd7 400 3 of of IN cord-259669-fod4xkd7 400 4 recombinant recombinant JJ cord-259669-fod4xkd7 400 5 classical classical JJ cord-259669-fod4xkd7 400 6 swine swine NN cord-259669-fod4xkd7 400 7 fever fever NN cord-259669-fod4xkd7 400 8 virus virus NN cord-259669-fod4xkd7 400 9 NS3 ns3 RB cord-259669-fod4xkd7 400 10 protein protein VBP cord-259669-fod4xkd7 400 11 in in IN cord-259669-fod4xkd7 400 12 vitro vitro FW cord-259669-fod4xkd7 400 13 and and CC cord-259669-fod4xkd7 400 14 in in IN cord-259669-fod4xkd7 400 15 vivo vivo NN cord-259669-fod4xkd7 401 1 An an DT cord-259669-fod4xkd7 401 2 in in IN cord-259669-fod4xkd7 401 3 vitro vitro FW cord-259669-fod4xkd7 401 4 immune immune JJ cord-259669-fod4xkd7 401 5 response response NN cord-259669-fod4xkd7 401 6 model model NN cord-259669-fod4xkd7 401 7 to to TO cord-259669-fod4xkd7 401 8 determine determine VB cord-259669-fod4xkd7 401 9 tetanus tetanus NN cord-259669-fod4xkd7 401 10 toxoid toxoid NN cord-259669-fod4xkd7 401 11 antigen antigen NN cord-259669-fod4xkd7 401 12 ( ( -LRB- cord-259669-fod4xkd7 401 13 vaccine vaccine NN cord-259669-fod4xkd7 401 14 ) ) -RRB- cord-259669-fod4xkd7 401 15 specific specific JJ cord-259669-fod4xkd7 401 16 immunogenicity immunogenicity NN cord-259669-fod4xkd7 401 17 : : : cord-259669-fod4xkd7 401 18 Selection selection NN cord-259669-fod4xkd7 401 19 of of IN cord-259669-fod4xkd7 401 20 sensitive sensitive JJ cord-259669-fod4xkd7 401 21 assay assay NN cord-259669-fod4xkd7 401 22 criteria criterion NNS cord-259669-fod4xkd7 401 23 Phenotypic phenotypic JJ cord-259669-fod4xkd7 401 24 and and CC cord-259669-fod4xkd7 401 25 functional functional JJ cord-259669-fod4xkd7 401 26 heterogeneity heterogeneity NN cord-259669-fod4xkd7 401 27 of of IN cord-259669-fod4xkd7 401 28 porcine porcine JJ cord-259669-fod4xkd7 401 29 blood blood NN cord-259669-fod4xkd7 401 30 monocytes monocyte NNS cord-259669-fod4xkd7 401 31 and and CC cord-259669-fod4xkd7 401 32 its -PRON- PRP$ cord-259669-fod4xkd7 401 33 relation relation NN cord-259669-fod4xkd7 401 34 with with IN cord-259669-fod4xkd7 401 35 maturation maturation NN cord-259669-fod4xkd7 402 1 The the DT cord-259669-fod4xkd7 402 2 porcine porcine JJ cord-259669-fod4xkd7 402 3 2A10 2a10 CD cord-259669-fod4xkd7 402 4 antigen antigen NN cord-259669-fod4xkd7 402 5 is be VBZ cord-259669-fod4xkd7 402 6 homologous homologous JJ cord-259669-fod4xkd7 402 7 to to IN cord-259669-fod4xkd7 402 8 human human JJ cord-259669-fod4xkd7 402 9 CD163 CD163 NNP cord-259669-fod4xkd7 402 10 and and CC cord-259669-fod4xkd7 402 11 related relate VBN cord-259669-fod4xkd7 402 12 to to IN cord-259669-fod4xkd7 402 13 macrophage macrophage NN cord-259669-fod4xkd7 402 14 differentiation differentiation NN cord-259669-fod4xkd7 402 15 Professional professional JJ cord-259669-fod4xkd7 402 16 and and CC cord-259669-fod4xkd7 402 17 non non JJ cord-259669-fod4xkd7 402 18 - - JJ cord-259669-fod4xkd7 402 19 professional professional JJ cord-259669-fod4xkd7 402 20 antigen antigen NN cord-259669-fod4xkd7 402 21 - - HYPH cord-259669-fod4xkd7 402 22 presenting present VBG cord-259669-fod4xkd7 402 23 cells cell NNS cord-259669-fod4xkd7 402 24 in in IN cord-259669-fod4xkd7 402 25 the the DT cord-259669-fod4xkd7 402 26 porcine porcine JJ cord-259669-fod4xkd7 402 27 small small JJ cord-259669-fod4xkd7 402 28 intestine intestine NN cord-259669-fod4xkd7 402 29 Sitespecific Sitespecific NNP cord-259669-fod4xkd7 402 30 expression expression NN cord-259669-fod4xkd7 402 31 of of IN cord-259669-fod4xkd7 402 32 CD11b CD11b NNS cord-259669-fod4xkd7 402 33 and and CC cord-259669-fod4xkd7 402 34 SIRPalpha SIRPalpha NNP cord-259669-fod4xkd7 402 35 ( ( -LRB- cord-259669-fod4xkd7 402 36 CD172a CD172a NNP cord-259669-fod4xkd7 402 37 ) ) -RRB- cord-259669-fod4xkd7 402 38 on on IN cord-259669-fod4xkd7 402 39 dendritic dendritic JJ cord-259669-fod4xkd7 402 40 cells cell NNS cord-259669-fod4xkd7 402 41 : : : cord-259669-fod4xkd7 402 42 implications implication NNS cord-259669-fod4xkd7 402 43 for for IN cord-259669-fod4xkd7 402 44 their -PRON- PRP$ cord-259669-fod4xkd7 402 45 migration migration NN cord-259669-fod4xkd7 402 46 patterns pattern NNS cord-259669-fod4xkd7 402 47 in in IN cord-259669-fod4xkd7 402 48 the the DT cord-259669-fod4xkd7 402 49 gut gut NN cord-259669-fod4xkd7 402 50 immune immune JJ cord-259669-fod4xkd7 402 51 system system NN cord-259669-fod4xkd7 402 52 Lactic lactic NN cord-259669-fod4xkd7 402 53 acid acid NN cord-259669-fod4xkd7 402 54 bacterial bacterial JJ cord-259669-fod4xkd7 402 55 colonization colonization NN cord-259669-fod4xkd7 402 56 and and CC cord-259669-fod4xkd7 402 57 human human JJ cord-259669-fod4xkd7 402 58 rotavirus rotavirus NN cord-259669-fod4xkd7 402 59 infection infection NN cord-259669-fod4xkd7 402 60 influence influence NN cord-259669-fod4xkd7 402 61 distribution distribution NN cord-259669-fod4xkd7 402 62 and and CC cord-259669-fod4xkd7 402 63 frequencies frequency NNS cord-259669-fod4xkd7 402 64 of of IN cord-259669-fod4xkd7 402 65 monocytes/ monocytes/ NN cord-259669-fod4xkd7 402 66 macrophages macrophage NNS cord-259669-fod4xkd7 402 67 and and CC cord-259669-fod4xkd7 402 68 dendritic dendritic JJ cord-259669-fod4xkd7 402 69 cells cell NNS cord-259669-fod4xkd7 402 70 in in IN cord-259669-fod4xkd7 402 71 neonatal neonatal JJ cord-259669-fod4xkd7 402 72 gnotobiotic gnotobiotic JJ cord-259669-fod4xkd7 402 73 pigs pig NNS cord-259669-fod4xkd7 402 74 Characterization characterization NN cord-259669-fod4xkd7 402 75 of of IN cord-259669-fod4xkd7 402 76 conventional conventional JJ cord-259669-fod4xkd7 402 77 and and CC cord-259669-fod4xkd7 402 78 plasmacytoid plasmacytoid NN cord-259669-fod4xkd7 402 79 dendritic dendritic JJ cord-259669-fod4xkd7 402 80 cells cell NNS cord-259669-fod4xkd7 402 81 in in IN cord-259669-fod4xkd7 402 82 swine swine NN cord-259669-fod4xkd7 402 83 secondary secondary JJ cord-259669-fod4xkd7 402 84 lymphoid lymphoid JJ cord-259669-fod4xkd7 402 85 organs organ NNS cord-259669-fod4xkd7 402 86 and and CC cord-259669-fod4xkd7 402 87 blood blood NN cord-259669-fod4xkd7 402 88 Workshop Workshop NNP cord-259669-fod4xkd7 402 89 studies study NNS cord-259669-fod4xkd7 402 90 on on IN cord-259669-fod4xkd7 402 91 monoclonal monoclonal JJ cord-259669-fod4xkd7 402 92 antibodies antibody NNS cord-259669-fod4xkd7 402 93 in in IN cord-259669-fod4xkd7 402 94 the the DT cord-259669-fod4xkd7 402 95 myeloid myeloid JJ cord-259669-fod4xkd7 402 96 panel panel NN cord-259669-fod4xkd7 402 97 with with IN cord-259669-fod4xkd7 402 98 CD11 CD11 NNP cord-259669-fod4xkd7 402 99 specificity specificity NN cord-259669-fod4xkd7 402 100 Characterization characterization NN cord-259669-fod4xkd7 402 101 of of IN cord-259669-fod4xkd7 402 102 blood blood NN cord-259669-fod4xkd7 402 103 mononuclear mononuclear NN cord-259669-fod4xkd7 402 104 cells cell NNS cord-259669-fod4xkd7 402 105 producing produce VBG cord-259669-fod4xkd7 402 106 IFN IFN NNP cord-259669-fod4xkd7 402 107 alpha alpha NN cord-259669-fod4xkd7 402 108 following following NN cord-259669-fod4xkd7 402 109 induction induction NN cord-259669-fod4xkd7 402 110 by by IN cord-259669-fod4xkd7 402 111 coronavirus coronavirus NN cord-259669-fod4xkd7 402 112 - - HYPH cord-259669-fod4xkd7 402 113 infected infect VBN cord-259669-fod4xkd7 402 114 cells cell NNS cord-259669-fod4xkd7 402 115 ( ( -LRB- cord-259669-fod4xkd7 402 116 porcine porcine JJ cord-259669-fod4xkd7 402 117 transmissible transmissible JJ cord-259669-fod4xkd7 402 118 gastroenteritis gastroenteritis NN cord-259669-fod4xkd7 402 119 virus virus NN cord-259669-fod4xkd7 402 120 ) ) -RRB- cord-259669-fod4xkd7 402 121 Ontogeny ontogeny NN cord-259669-fod4xkd7 402 122 of of IN cord-259669-fod4xkd7 402 123 interferon interferon NN cord-259669-fod4xkd7 402 124 alpha alpha NN cord-259669-fod4xkd7 402 125 secreting secreting NN cord-259669-fod4xkd7 402 126 cells cell NNS cord-259669-fod4xkd7 402 127 in in IN cord-259669-fod4xkd7 402 128 the the DT cord-259669-fod4xkd7 402 129 porcine porcine JJ cord-259669-fod4xkd7 402 130 fetal fetal JJ cord-259669-fod4xkd7 402 131 hematopoietic hematopoietic JJ cord-259669-fod4xkd7 402 132 organs organ NNS cord-259669-fod4xkd7 403 1 In in IN cord-259669-fod4xkd7 403 2 vivo vivo NN cord-259669-fod4xkd7 403 3 study study NN cord-259669-fod4xkd7 403 4 of of IN cord-259669-fod4xkd7 403 5 interferon interferon NN cord-259669-fod4xkd7 403 6 - - HYPH cord-259669-fod4xkd7 403 7 alpha alpha NN cord-259669-fod4xkd7 403 8 - - HYPH cord-259669-fod4xkd7 403 9 secreting secrete VBG cord-259669-fod4xkd7 403 10 cells cell NNS cord-259669-fod4xkd7 403 11 in in IN cord-259669-fod4xkd7 403 12 pig pig NN cord-259669-fod4xkd7 403 13 foetal foetal JJ cord-259669-fod4xkd7 403 14 lymphohaematopoietic lymphohaematopoietic JJ cord-259669-fod4xkd7 403 15 organs organ NNS cord-259669-fod4xkd7 403 16 following follow VBG cord-259669-fod4xkd7 403 17 in in IN cord-259669-fod4xkd7 403 18 utero utero NN cord-259669-fod4xkd7 403 19 TGEV TGEV NNP cord-259669-fod4xkd7 403 20 coronavirus coronavirus NN cord-259669-fod4xkd7 403 21 injection injection NN cord-259669-fod4xkd7 404 1 In in IN cord-259669-fod4xkd7 404 2 vivo vivo NN cord-259669-fod4xkd7 404 3 induction induction NN cord-259669-fod4xkd7 404 4 of of IN cord-259669-fod4xkd7 404 5 interferon interferon NN cord-259669-fod4xkd7 404 6 - - HYPH cord-259669-fod4xkd7 404 7 alpha alpha NN cord-259669-fod4xkd7 404 8 in in IN cord-259669-fod4xkd7 404 9 pig pig NN cord-259669-fod4xkd7 404 10 by by IN cord-259669-fod4xkd7 404 11 noninfectious noninfectious JJ cord-259669-fod4xkd7 404 12 coronavirus coronavirus NN cord-259669-fod4xkd7 404 13 : : : cord-259669-fod4xkd7 404 14 tissue tissue NN cord-259669-fod4xkd7 404 15 localization localization NN cord-259669-fod4xkd7 404 16 and and CC cord-259669-fod4xkd7 404 17 in in IN cord-259669-fod4xkd7 404 18 situ situ JJ cord-259669-fod4xkd7 404 19 phenotypic phenotypic JJ cord-259669-fod4xkd7 404 20 characterization characterization NN cord-259669-fod4xkd7 404 21 of of IN cord-259669-fod4xkd7 404 22 interferon interferon NN cord-259669-fod4xkd7 404 23 - - HYPH cord-259669-fod4xkd7 404 24 alphaproducing alphaproduce VBG cord-259669-fod4xkd7 404 25 cells cell NNS cord-259669-fod4xkd7 405 1 Interferon interferon NN cord-259669-fod4xkd7 405 2 - - HYPH cord-259669-fod4xkd7 405 3 alphaproducing alphaproducing NN cord-259669-fod4xkd7 405 4 cells cell NNS cord-259669-fod4xkd7 405 5 are be VBP cord-259669-fod4xkd7 405 6 localized localize VBN cord-259669-fod4xkd7 405 7 in in IN cord-259669-fod4xkd7 405 8 gut gut NN cord-259669-fod4xkd7 405 9 - - HYPH cord-259669-fod4xkd7 405 10 associated associate VBN cord-259669-fod4xkd7 405 11 lymphoid lymphoid JJ cord-259669-fod4xkd7 405 12 tissues tissue NNS cord-259669-fod4xkd7 405 13 in in IN cord-259669-fod4xkd7 405 14 transmissible transmissible JJ cord-259669-fod4xkd7 405 15 gastroenteritis gastroenteritis NN cord-259669-fod4xkd7 405 16 virus virus NN cord-259669-fod4xkd7 405 17 ( ( -LRB- cord-259669-fod4xkd7 405 18 TGEV TGEV NNP cord-259669-fod4xkd7 405 19 ) ) -RRB- cord-259669-fod4xkd7 405 20 infected infect VBN cord-259669-fod4xkd7 405 21 piglets piglet NNS cord-259669-fod4xkd7 405 22 Plasmacytoid Plasmacytoid NNP cord-259669-fod4xkd7 405 23 dendritic dendritic JJ cord-259669-fod4xkd7 405 24 cells cell NNS cord-259669-fod4xkd7 405 25 migrate migrate VBP cord-259669-fod4xkd7 405 26 in in IN cord-259669-fod4xkd7 405 27 afferent afferent JJ cord-259669-fod4xkd7 405 28 skin skin NN cord-259669-fod4xkd7 405 29 lymph lymph NN cord-259669-fod4xkd7 405 30 FcgammaRII fcgammarii JJ cord-259669-fod4xkd7 405 31 - - HYPH cord-259669-fod4xkd7 405 32 dependent dependent JJ cord-259669-fod4xkd7 405 33 sensitisation sensitisation NN cord-259669-fod4xkd7 405 34 of of IN cord-259669-fod4xkd7 405 35 natural natural JJ cord-259669-fod4xkd7 405 36 interferon interferon NN cord-259669-fod4xkd7 405 37 - - HYPH cord-259669-fod4xkd7 405 38 producing produce VBG cord-259669-fod4xkd7 405 39 cells cell NNS cord-259669-fod4xkd7 405 40 for for IN cord-259669-fod4xkd7 405 41 viral viral JJ cord-259669-fod4xkd7 405 42 infection infection NN cord-259669-fod4xkd7 405 43 and and CC cord-259669-fod4xkd7 405 44 interferon interferon NN cord-259669-fod4xkd7 405 45 - - HYPH cord-259669-fod4xkd7 405 46 alpha alpha NN cord-259669-fod4xkd7 405 47 responses response NNS cord-259669-fod4xkd7 405 48 Type type NN cord-259669-fod4xkd7 405 49 - - : cord-259669-fod4xkd7 405 50 A A NNP cord-259669-fod4xkd7 405 51 CpG cpg NN cord-259669-fod4xkd7 405 52 oligonucleotides oligonucleotide NNS cord-259669-fod4xkd7 405 53 activate activate VBP cord-259669-fod4xkd7 405 54 exclusively exclusively RB cord-259669-fod4xkd7 405 55 porcine porcine JJ cord-259669-fod4xkd7 405 56 natural natural JJ cord-259669-fod4xkd7 405 57 interferon interferon NN cord-259669-fod4xkd7 405 58 - - HYPH cord-259669-fod4xkd7 405 59 producing produce VBG cord-259669-fod4xkd7 405 60 cells cell NNS cord-259669-fod4xkd7 405 61 to to IN cord-259669-fod4xkd7 405 62 secrete secrete VB cord-259669-fod4xkd7 405 63 interferonalpha interferonalpha NN cord-259669-fod4xkd7 405 64 , , , cord-259669-fod4xkd7 405 65 tumour tumour NN cord-259669-fod4xkd7 405 66 necrosis necrosis NN cord-259669-fod4xkd7 405 67 factor factor NN cord-259669-fod4xkd7 405 68 - - HYPH cord-259669-fod4xkd7 405 69 alpha alpha NN cord-259669-fod4xkd7 405 70 and and CC cord-259669-fod4xkd7 405 71 interleukin-12 interleukin-12 NNP cord-259669-fod4xkd7 406 1 Of of IN cord-259669-fod4xkd7 406 2 men man NNS cord-259669-fod4xkd7 406 3 , , , cord-259669-fod4xkd7 406 4 mice mouse NNS cord-259669-fod4xkd7 406 5 and and CC cord-259669-fod4xkd7 406 6 pigs pig NNS cord-259669-fod4xkd7 406 7 : : : cord-259669-fod4xkd7 406 8 looking look VBG cord-259669-fod4xkd7 406 9 at at IN cord-259669-fod4xkd7 406 10 their -PRON- PRP$ cord-259669-fod4xkd7 406 11 plasmacytoid plasmacytoid NN cord-259669-fod4xkd7 406 12 dendritic dendritic JJ cord-259669-fod4xkd7 406 13 cells cell NNS cord-259669-fod4xkd7 406 14 Isolation isolation NN cord-259669-fod4xkd7 406 15 and and CC cord-259669-fod4xkd7 406 16 characterisation characterisation NN cord-259669-fod4xkd7 406 17 of of IN cord-259669-fod4xkd7 406 18 pig pig NN cord-259669-fod4xkd7 406 19 Peyer Peyer NNP cord-259669-fod4xkd7 406 20 's 's POS cord-259669-fod4xkd7 406 21 patch patch NN cord-259669-fod4xkd7 406 22 dendritic dendritic JJ cord-259669-fod4xkd7 406 23 cells cell NNS cord-259669-fod4xkd7 406 24 Phenotype phenotype NN cord-259669-fod4xkd7 406 25 and and CC cord-259669-fod4xkd7 406 26 distribution distribution NN cord-259669-fod4xkd7 406 27 of of IN cord-259669-fod4xkd7 406 28 dendritic dendritic JJ cord-259669-fod4xkd7 406 29 cells cell NNS cord-259669-fod4xkd7 406 30 in in IN cord-259669-fod4xkd7 406 31 the the DT cord-259669-fod4xkd7 406 32 porcine porcine JJ cord-259669-fod4xkd7 406 33 small small JJ cord-259669-fod4xkd7 406 34 intestinal intestinal JJ cord-259669-fod4xkd7 406 35 and and CC cord-259669-fod4xkd7 406 36 tracheal tracheal JJ cord-259669-fod4xkd7 406 37 mucosa mucosa NN cord-259669-fod4xkd7 406 38 and and CC cord-259669-fod4xkd7 406 39 their -PRON- PRP$ cord-259669-fod4xkd7 406 40 spatial spatial JJ cord-259669-fod4xkd7 406 41 relationship relationship NN cord-259669-fod4xkd7 406 42 to to IN cord-259669-fod4xkd7 406 43 epithelial epithelial JJ cord-259669-fod4xkd7 406 44 cells cell NNS cord-259669-fod4xkd7 406 45 Characterization characterization NN cord-259669-fod4xkd7 406 46 and and CC cord-259669-fod4xkd7 406 47 functional functional JJ cord-259669-fod4xkd7 406 48 analysis analysis NN cord-259669-fod4xkd7 406 49 of of IN cord-259669-fod4xkd7 406 50 skin skin NN cord-259669-fod4xkd7 406 51 - - HYPH cord-259669-fod4xkd7 406 52 derived derive VBN cord-259669-fod4xkd7 406 53 dendritic dendritic JJ cord-259669-fod4xkd7 406 54 cells cell NNS cord-259669-fod4xkd7 406 55 from from IN cord-259669-fod4xkd7 406 56 swine swine NN cord-259669-fod4xkd7 406 57 without without IN cord-259669-fod4xkd7 406 58 a a DT cord-259669-fod4xkd7 406 59 requirement requirement NN cord-259669-fod4xkd7 406 60 for for IN cord-259669-fod4xkd7 406 61 in in FW cord-259669-fod4xkd7 406 62 vitro vitro FW cord-259669-fod4xkd7 406 63 propagation propagation NN cord-259669-fod4xkd7 407 1 Plasmacytoid Plasmacytoid NNP cord-259669-fod4xkd7 407 2 dendritic dendritic JJ cord-259669-fod4xkd7 407 3 cell cell NN cord-259669-fod4xkd7 407 4 activation activation NN cord-259669-fod4xkd7 407 5 by by IN cord-259669-fod4xkd7 407 6 foot foot NN cord-259669-fod4xkd7 407 7 - - HYPH cord-259669-fod4xkd7 407 8 and and CC cord-259669-fod4xkd7 407 9 - - HYPH cord-259669-fod4xkd7 407 10 mouth mouth NN cord-259669-fod4xkd7 407 11 disease disease NN cord-259669-fod4xkd7 407 12 virus virus NN cord-259669-fod4xkd7 407 13 requires require VBZ cord-259669-fod4xkd7 407 14 immune immune JJ cord-259669-fod4xkd7 407 15 complexes complex NNS cord-259669-fod4xkd7 407 16 Role role NN cord-259669-fod4xkd7 407 17 of of IN cord-259669-fod4xkd7 407 18 natural natural JJ cord-259669-fod4xkd7 407 19 interferon interferon NN cord-259669-fod4xkd7 407 20 - - HYPH cord-259669-fod4xkd7 407 21 producing produce VBG cord-259669-fod4xkd7 407 22 cells cell NNS cord-259669-fod4xkd7 407 23 and and CC cord-259669-fod4xkd7 407 24 T t NN cord-259669-fod4xkd7 407 25 lymphocytes lymphocyte NNS cord-259669-fod4xkd7 407 26 in in IN cord-259669-fod4xkd7 407 27 porcine porcine JJ cord-259669-fod4xkd7 407 28 monocyte monocyte NN cord-259669-fod4xkd7 407 29 - - HYPH cord-259669-fod4xkd7 407 30 derived derive VBN cord-259669-fod4xkd7 407 31 dendritic dendritic JJ cord-259669-fod4xkd7 407 32 cell cell NN cord-259669-fod4xkd7 407 33 maturation maturation NN cord-259669-fod4xkd7 408 1 A a DT cord-259669-fod4xkd7 408 2 discrete discrete JJ cord-259669-fod4xkd7 408 3 subpopulation subpopulation NN cord-259669-fod4xkd7 408 4 of of IN cord-259669-fod4xkd7 408 5 dendritic dendritic JJ cord-259669-fod4xkd7 408 6 cells cell NNS cord-259669-fod4xkd7 408 7 transports transport VBZ cord-259669-fod4xkd7 408 8 apoptotic apoptotic JJ cord-259669-fod4xkd7 408 9 intestinal intestinal JJ cord-259669-fod4xkd7 408 10 epithelial epithelial JJ cord-259669-fod4xkd7 408 11 cells cell NNS cord-259669-fod4xkd7 408 12 to to IN cord-259669-fod4xkd7 408 13 T t NN cord-259669-fod4xkd7 408 14 cell cell NN cord-259669-fod4xkd7 408 15 areas area NNS cord-259669-fod4xkd7 408 16 of of IN cord-259669-fod4xkd7 408 17 mesenteric mesenteric JJ cord-259669-fod4xkd7 408 18 lymph lymph NN cord-259669-fod4xkd7 408 19 nodes node NNS cord-259669-fod4xkd7 409 1 Dendritic dendritic JJ cord-259669-fod4xkd7 409 2 cell cell NN cord-259669-fod4xkd7 409 3 heterogeneity heterogeneity NN cord-259669-fod4xkd7 409 4 in in IN cord-259669-fod4xkd7 409 5 vivo vivo NN cord-259669-fod4xkd7 409 6 : : : cord-259669-fod4xkd7 409 7 two two CD cord-259669-fod4xkd7 409 8 functionally functionally RB cord-259669-fod4xkd7 409 9 different different JJ cord-259669-fod4xkd7 409 10 dendritic dendritic JJ cord-259669-fod4xkd7 409 11 cell cell NN cord-259669-fod4xkd7 409 12 populations population NNS cord-259669-fod4xkd7 409 13 in in IN cord-259669-fod4xkd7 409 14 rat rat NN cord-259669-fod4xkd7 409 15 intestinal intestinal JJ cord-259669-fod4xkd7 409 16 lymph lymph NN cord-259669-fod4xkd7 409 17 can can MD cord-259669-fod4xkd7 409 18 be be VB cord-259669-fod4xkd7 409 19 distinguished distinguish VBN cord-259669-fod4xkd7 409 20 by by IN cord-259669-fod4xkd7 409 21 CD4 CD4 NNP cord-259669-fod4xkd7 409 22 expression expression NN cord-259669-fod4xkd7 409 23 Identification Identification NNP cord-259669-fod4xkd7 409 24 of of IN cord-259669-fod4xkd7 409 25 two two CD cord-259669-fod4xkd7 409 26 distinct distinct JJ cord-259669-fod4xkd7 409 27 populations population NNS cord-259669-fod4xkd7 409 28 of of IN cord-259669-fod4xkd7 409 29 dendritic dendritic JJ cord-259669-fod4xkd7 409 30 cells cell NNS cord-259669-fod4xkd7 409 31 in in IN cord-259669-fod4xkd7 409 32 afferent afferent JJ cord-259669-fod4xkd7 409 33 lymph lymph NN cord-259669-fod4xkd7 409 34 that that WDT cord-259669-fod4xkd7 409 35 vary vary VBP cord-259669-fod4xkd7 409 36 in in IN cord-259669-fod4xkd7 409 37 their -PRON- PRP$ cord-259669-fod4xkd7 409 38 ability ability NN cord-259669-fod4xkd7 409 39 to to TO cord-259669-fod4xkd7 409 40 stimulate stimulate VB cord-259669-fod4xkd7 409 41 Tcells Tcells NNP cord-259669-fod4xkd7 409 42 Enrichment Enrichment NNP cord-259669-fod4xkd7 409 43 for for IN cord-259669-fod4xkd7 409 44 a a DT cord-259669-fod4xkd7 409 45 CD26hi CD26hi NNP cord-259669-fod4xkd7 409 46 SIRP SIRP NNP cord-259669-fod4xkd7 409 47 - - HYPH cord-259669-fod4xkd7 409 48 subset subset VBN cord-259669-fod4xkd7 409 49 in in IN cord-259669-fod4xkd7 409 50 lymph lymph NN cord-259669-fod4xkd7 409 51 dendritic dendritic JJ cord-259669-fod4xkd7 409 52 cells cell NNS cord-259669-fod4xkd7 409 53 from from IN cord-259669-fod4xkd7 409 54 the the DT cord-259669-fod4xkd7 409 55 upper upper JJ cord-259669-fod4xkd7 409 56 aero aero NN cord-259669-fod4xkd7 409 57 - - JJ cord-259669-fod4xkd7 409 58 digestive digestive JJ cord-259669-fod4xkd7 409 59 tract tract NN cord-259669-fod4xkd7 409 60 Bidirectional bidirectional JJ cord-259669-fod4xkd7 409 61 negative negative JJ cord-259669-fod4xkd7 409 62 regulation regulation NN cord-259669-fod4xkd7 409 63 of of IN cord-259669-fod4xkd7 409 64 human human JJ cord-259669-fod4xkd7 409 65 T t NN cord-259669-fod4xkd7 409 66 and and CC cord-259669-fod4xkd7 409 67 dendritic dendritic JJ cord-259669-fod4xkd7 409 68 cells cell NNS cord-259669-fod4xkd7 409 69 by by IN cord-259669-fod4xkd7 409 70 CD47 CD47 NNP cord-259669-fod4xkd7 409 71 and and CC cord-259669-fod4xkd7 410 1 its -PRON- PRP$ cord-259669-fod4xkd7 410 2 cognate cognate JJ cord-259669-fod4xkd7 410 3 receptor receptor NN cord-259669-fod4xkd7 410 4 signalregulator signalregulator NN cord-259669-fod4xkd7 410 5 protein protein NN cord-259669-fod4xkd7 410 6 - - HYPH cord-259669-fod4xkd7 410 7 alpha alpha NN cord-259669-fod4xkd7 410 8 : : HYPH cord-259669-fod4xkd7 410 9 down down IN cord-259669-fod4xkd7 410 10 - - HYPH cord-259669-fod4xkd7 410 11 regulation regulation NN cord-259669-fod4xkd7 410 12 of of IN cord-259669-fod4xkd7 410 13 IL-12 IL-12 NNP cord-259669-fod4xkd7 410 14 responsiveness responsiveness NN cord-259669-fod4xkd7 410 15 and and CC cord-259669-fod4xkd7 410 16 inhibition inhibition NN cord-259669-fod4xkd7 410 17 of of IN cord-259669-fod4xkd7 410 18 dendritic dendritic JJ cord-259669-fod4xkd7 410 19 cell cell NN cord-259669-fod4xkd7 410 20 activation activation NN cord-259669-fod4xkd7 410 21 Mucosal Mucosal NNP cord-259669-fod4xkd7 410 22 dendritic dendritic JJ cord-259669-fod4xkd7 410 23 cells cell NNS cord-259669-fod4xkd7 410 24 Gut gut VBP cord-259669-fod4xkd7 410 25 lymphocyte lymphocyte NN cord-259669-fod4xkd7 410 26 migration migration NN cord-259669-fod4xkd7 411 1 : : : cord-259669-fod4xkd7 411 2 we -PRON- PRP cord-259669-fod4xkd7 411 3 are be VBP cord-259669-fod4xkd7 411 4 halfway halfway RB cord-259669-fod4xkd7 411 5 ' ' `` cord-259669-fod4xkd7 411 6 home home NN cord-259669-fod4xkd7 411 7 ' ' '' cord-259669-fod4xkd7 411 8 Generation generation NN cord-259669-fod4xkd7 411 9 of of IN cord-259669-fod4xkd7 411 10 gut gut NN cord-259669-fod4xkd7 411 11 - - HYPH cord-259669-fod4xkd7 411 12 homing home VBG cord-259669-fod4xkd7 411 13 IgA IgA NNP cord-259669-fod4xkd7 411 14 - - HYPH cord-259669-fod4xkd7 411 15 secreting secrete VBG cord-259669-fod4xkd7 411 16 B b NN cord-259669-fod4xkd7 411 17 cells cell NNS cord-259669-fod4xkd7 411 18 by by IN cord-259669-fod4xkd7 411 19 intestinal intestinal JJ cord-259669-fod4xkd7 411 20 dendritic dendritic JJ cord-259669-fod4xkd7 411 21 cells cell NNS cord-259669-fod4xkd7 411 22 Small small JJ cord-259669-fod4xkd7 411 23 intestine intestine NN cord-259669-fod4xkd7 411 24 lamina lamina NN cord-259669-fod4xkd7 411 25 propria propria NN cord-259669-fod4xkd7 411 26 dendritic dendritic JJ cord-259669-fod4xkd7 411 27 cells cell NNS cord-259669-fod4xkd7 411 28 promote promote VBP cord-259669-fod4xkd7 411 29 de de FW cord-259669-fod4xkd7 411 30 novo novo NNP cord-259669-fod4xkd7 411 31 generation generation NN cord-259669-fod4xkd7 411 32 of of IN cord-259669-fod4xkd7 411 33 Foxp3 foxp3 JJ cord-259669-fod4xkd7 411 34 Treg Treg NNP cord-259669-fod4xkd7 411 35 cells cell NNS cord-259669-fod4xkd7 411 36 via via IN cord-259669-fod4xkd7 411 37 retinoic retinoic JJ cord-259669-fod4xkd7 411 38 acid acid NN cord-259669-fod4xkd7 411 39 Reciprocal Reciprocal NNP cord-259669-fod4xkd7 411 40 TH17 TH17 NNP cord-259669-fod4xkd7 411 41 and and CC cord-259669-fod4xkd7 411 42 regulatory regulatory JJ cord-259669-fod4xkd7 411 43 T t NN cord-259669-fod4xkd7 411 44 cell cell NN cord-259669-fod4xkd7 411 45 differentiation differentiation NN cord-259669-fod4xkd7 411 46 mediated mediate VBN cord-259669-fod4xkd7 411 47 by by IN cord-259669-fod4xkd7 411 48 retinoic retinoic JJ cord-259669-fod4xkd7 411 49 acid acid NN cord-259669-fod4xkd7 412 1 In in IN cord-259669-fod4xkd7 412 2 vitro vitro FW cord-259669-fod4xkd7 412 3 induction induction NN cord-259669-fod4xkd7 412 4 of of IN cord-259669-fod4xkd7 412 5 mucosa mucosa JJ cord-259669-fod4xkd7 412 6 - - HYPH cord-259669-fod4xkd7 412 7 type type NN cord-259669-fod4xkd7 412 8 dendritic dendritic JJ cord-259669-fod4xkd7 412 9 cells cell NNS cord-259669-fod4xkd7 412 10 by by IN cord-259669-fod4xkd7 412 11 all all RB cord-259669-fod4xkd7 412 12 - - HYPH cord-259669-fod4xkd7 412 13 trans trans NNP cord-259669-fod4xkd7 412 14 retinoic retinoic NN cord-259669-fod4xkd7 412 15 acid acid NN cord-259669-fod4xkd7 412 16 CCR9 CCR9 NNP cord-259669-fod4xkd7 412 17 is be VBZ cord-259669-fod4xkd7 412 18 a a DT cord-259669-fod4xkd7 412 19 homing homing NN cord-259669-fod4xkd7 412 20 receptor receptor NN cord-259669-fod4xkd7 412 21 for for IN cord-259669-fod4xkd7 412 22 plasmacytoid plasmacytoid NNP cord-259669-fod4xkd7 412 23 dendritic dendritic JJ cord-259669-fod4xkd7 412 24 cells cell NNS cord-259669-fod4xkd7 412 25 to to IN cord-259669-fod4xkd7 412 26 the the DT cord-259669-fod4xkd7 412 27 small small JJ cord-259669-fod4xkd7 412 28 intestine intestine NN cord-259669-fod4xkd7 412 29 Dendritic dendritic JJ cord-259669-fod4xkd7 412 30 cells cell NNS cord-259669-fod4xkd7 412 31 enriched enrich VBN cord-259669-fod4xkd7 412 32 from from IN cord-259669-fod4xkd7 412 33 swine swine NN cord-259669-fod4xkd7 412 34 thymus thymus NN cord-259669-fod4xkd7 412 35 coexpress coexpress NN cord-259669-fod4xkd7 412 36 CD1 CD1 NNP cord-259669-fod4xkd7 412 37 , , , cord-259669-fod4xkd7 412 38 CD2 CD2 NNP cord-259669-fod4xkd7 412 39 and and CC cord-259669-fod4xkd7 412 40 major major JJ cord-259669-fod4xkd7 412 41 histocompatibility histocompatibility NN cord-259669-fod4xkd7 412 42 complex complex JJ cord-259669-fod4xkd7 412 43 class class NN cord-259669-fod4xkd7 412 44 II ii NN cord-259669-fod4xkd7 412 45 and and CC cord-259669-fod4xkd7 412 46 actively actively RB cord-259669-fod4xkd7 412 47 stimulate stimulate VBP cord-259669-fod4xkd7 412 48 alloreactive alloreactive JJ cord-259669-fod4xkd7 412 49 T t NN cord-259669-fod4xkd7 412 50 lymphocytes lymphocyte NNS cord-259669-fod4xkd7 412 51 Culture culture NN cord-259669-fod4xkd7 412 52 of of IN cord-259669-fod4xkd7 412 53 dendritic dendritic JJ cord-259669-fod4xkd7 412 54 cells cell NNS cord-259669-fod4xkd7 412 55 from from IN cord-259669-fod4xkd7 412 56 a a DT cord-259669-fod4xkd7 412 57 nonlymphoid nonlymphoid JJ cord-259669-fod4xkd7 412 58 organ organ NN cord-259669-fod4xkd7 412 59 , , , cord-259669-fod4xkd7 412 60 the the DT cord-259669-fod4xkd7 412 61 thyroid thyroid NN cord-259669-fod4xkd7 412 62 gland gland NN cord-259669-fod4xkd7 412 63 : : : cord-259669-fod4xkd7 412 64 evidence evidence NN cord-259669-fod4xkd7 412 65 for for IN cord-259669-fod4xkd7 412 66 TNFalphadependent tnfalphadependent NN cord-259669-fod4xkd7 412 67 phenotypic phenotypic JJ cord-259669-fod4xkd7 412 68 changes change NNS cord-259669-fod4xkd7 412 69 of of IN cord-259669-fod4xkd7 412 70 thyroid thyroid NN cord-259669-fod4xkd7 412 71 - - HYPH cord-259669-fod4xkd7 412 72 derived derive VBN cord-259669-fod4xkd7 412 73 dendritic dendritic JJ cord-259669-fod4xkd7 412 74 cells cell NNS cord-259669-fod4xkd7 413 1 Circulating circulate VBG cord-259669-fod4xkd7 413 2 fibrocytes fibrocyte NNS cord-259669-fod4xkd7 413 3 define define VBP cord-259669-fod4xkd7 413 4 a a DT cord-259669-fod4xkd7 413 5 new new JJ cord-259669-fod4xkd7 413 6 leukocyte leukocyte NN cord-259669-fod4xkd7 413 7 subpopulation subpopulation NN cord-259669-fod4xkd7 413 8 that that WDT cord-259669-fod4xkd7 413 9 mediates mediate VBZ cord-259669-fod4xkd7 413 10 tissue tissue NN cord-259669-fod4xkd7 413 11 repair repair NN cord-259669-fod4xkd7 414 1 The the DT cord-259669-fod4xkd7 414 2 peripheral peripheral JJ cord-259669-fod4xkd7 414 3 blood blood NN cord-259669-fod4xkd7 414 4 fibrocyte fibrocyte NNP cord-259669-fod4xkd7 414 5 is be VBZ cord-259669-fod4xkd7 414 6 a a DT cord-259669-fod4xkd7 414 7 potent potent JJ cord-259669-fod4xkd7 414 8 antigen antigen NN cord-259669-fod4xkd7 414 9 - - HYPH cord-259669-fod4xkd7 414 10 presenting present VBG cord-259669-fod4xkd7 414 11 cell cell NN cord-259669-fod4xkd7 414 12 capable capable JJ cord-259669-fod4xkd7 414 13 of of IN cord-259669-fod4xkd7 414 14 priming prime VBG cord-259669-fod4xkd7 414 15 naive naive JJ cord-259669-fod4xkd7 414 16 T t NN cord-259669-fod4xkd7 414 17 cells cell NNS cord-259669-fod4xkd7 414 18 in in IN cord-259669-fod4xkd7 414 19 situ situ JJ cord-259669-fod4xkd7 414 20 Peripheral peripheral JJ cord-259669-fod4xkd7 414 21 blood blood NN cord-259669-fod4xkd7 414 22 fibrocytes fibrocyte NNS cord-259669-fod4xkd7 414 23 : : : cord-259669-fod4xkd7 414 24 differentiation differentiation NN cord-259669-fod4xkd7 414 25 pathway pathway NN cord-259669-fod4xkd7 414 26 and and CC cord-259669-fod4xkd7 414 27 migration migration NN cord-259669-fod4xkd7 414 28 to to TO cord-259669-fod4xkd7 414 29 wound wound VB cord-259669-fod4xkd7 414 30 sites site NNS cord-259669-fod4xkd7 414 31 Responsiveness Responsiveness NNP cord-259669-fod4xkd7 414 32 of of IN cord-259669-fod4xkd7 414 33 fibrocytes fibrocyte NNS cord-259669-fod4xkd7 414 34 to to IN cord-259669-fod4xkd7 414 35 Toll Toll NNP cord-259669-fod4xkd7 414 36 - - HYPH cord-259669-fod4xkd7 414 37 like like JJ cord-259669-fod4xkd7 414 38 receptor receptor NN cord-259669-fod4xkd7 414 39 danger danger NN cord-259669-fod4xkd7 414 40 signals signal NNS cord-259669-fod4xkd7 414 41 Regulated regulated JJ cord-259669-fod4xkd7 414 42 production production NN cord-259669-fod4xkd7 414 43 of of IN cord-259669-fod4xkd7 414 44 type type NN cord-259669-fod4xkd7 414 45 I -PRON- PRP cord-259669-fod4xkd7 414 46 collagen collagen NN cord-259669-fod4xkd7 414 47 and and CC cord-259669-fod4xkd7 414 48 inflammatory inflammatory JJ cord-259669-fod4xkd7 414 49 cytokines cytokine NNS cord-259669-fod4xkd7 414 50 by by IN cord-259669-fod4xkd7 414 51 peripheral peripheral JJ cord-259669-fod4xkd7 414 52 blood blood NN cord-259669-fod4xkd7 414 53 fibrocytes fibrocyte NNS cord-259669-fod4xkd7 414 54 Interaction Interaction NNP cord-259669-fod4xkd7 414 55 of of IN cord-259669-fod4xkd7 414 56 Borrelia Borrelia NNP cord-259669-fod4xkd7 414 57 burgdorferi burgdorferi NN cord-259669-fod4xkd7 414 58 with with IN cord-259669-fod4xkd7 414 59 peripheral peripheral JJ cord-259669-fod4xkd7 414 60 blood blood NN cord-259669-fod4xkd7 414 61 fibrocytes fibrocyte NNS cord-259669-fod4xkd7 414 62 , , , cord-259669-fod4xkd7 414 63 antigen antigen NN cord-259669-fod4xkd7 414 64 - - HYPH cord-259669-fod4xkd7 414 65 presenting present VBG cord-259669-fod4xkd7 414 66 cells cell NNS cord-259669-fod4xkd7 414 67 with with IN cord-259669-fod4xkd7 414 68 the the DT cord-259669-fod4xkd7 414 69 potential potential NN cord-259669-fod4xkd7 414 70 for for IN cord-259669-fod4xkd7 414 71 connective connective JJ cord-259669-fod4xkd7 414 72 tissue tissue NN cord-259669-fod4xkd7 414 73 targeting target VBG cord-259669-fod4xkd7 414 74 Dendritic dendritic JJ cord-259669-fod4xkd7 414 75 cells cell NNS cord-259669-fod4xkd7 414 76 in in IN cord-259669-fod4xkd7 414 77 immunity immunity NN cord-259669-fod4xkd7 414 78 and and CC cord-259669-fod4xkd7 414 79 tolerance tolerance NN cord-259669-fod4xkd7 414 80 - - : cord-259669-fod4xkd7 414 81 do do VBP cord-259669-fod4xkd7 414 82 they -PRON- PRP cord-259669-fod4xkd7 414 83 display display VB cord-259669-fod4xkd7 414 84 opposite opposite JJ cord-259669-fod4xkd7 414 85 functions function NNS cord-259669-fod4xkd7 414 86 ? ? . cord-259669-fod4xkd7 415 1 The the DT cord-259669-fod4xkd7 415 2 danger danger NN cord-259669-fod4xkd7 415 3 model model NN cord-259669-fod4xkd7 415 4 : : : cord-259669-fod4xkd7 415 5 a a DT cord-259669-fod4xkd7 415 6 renewed renew VBN cord-259669-fod4xkd7 415 7 sense sense NN cord-259669-fod4xkd7 415 8 of of IN cord-259669-fod4xkd7 415 9 self self NN cord-259669-fod4xkd7 415 10 Interaction Interaction NNP cord-259669-fod4xkd7 415 11 of of IN cord-259669-fod4xkd7 415 12 classical classical JJ cord-259669-fod4xkd7 415 13 swine swine NN cord-259669-fod4xkd7 415 14 fever fever NN cord-259669-fod4xkd7 415 15 virus virus NN cord-259669-fod4xkd7 415 16 with with IN cord-259669-fod4xkd7 415 17 dendritic dendritic JJ cord-259669-fod4xkd7 415 18 cells cell NNS cord-259669-fod4xkd7 415 19 Effects effect NNS cord-259669-fod4xkd7 415 20 of of IN cord-259669-fod4xkd7 415 21 antigen antigen NN cord-259669-fod4xkd7 415 22 and and CC cord-259669-fod4xkd7 415 23 recombinant recombinant JJ cord-259669-fod4xkd7 415 24 porcine porcine JJ cord-259669-fod4xkd7 415 25 cytokines cytokine NNS cord-259669-fod4xkd7 415 26 on on IN cord-259669-fod4xkd7 415 27 pig pig NN cord-259669-fod4xkd7 415 28 dendritic dendritic JJ cord-259669-fod4xkd7 415 29 cell cell NN cord-259669-fod4xkd7 415 30 cytokine cytokine NN cord-259669-fod4xkd7 415 31 expression expression NN cord-259669-fod4xkd7 415 32 in in IN cord-259669-fod4xkd7 415 33 vitro vitro FW cord-259669-fod4xkd7 415 34 Silencing silencing NN cord-259669-fod4xkd7 415 35 of of IN cord-259669-fod4xkd7 415 36 natural natural JJ cord-259669-fod4xkd7 415 37 interferon interferon NN cord-259669-fod4xkd7 415 38 producing produce VBG cord-259669-fod4xkd7 415 39 cell cell NN cord-259669-fod4xkd7 415 40 activation activation NN cord-259669-fod4xkd7 415 41 by by IN cord-259669-fod4xkd7 415 42 porcine porcine JJ cord-259669-fod4xkd7 415 43 circovirus circovirus JJ cord-259669-fod4xkd7 415 44 type type NN cord-259669-fod4xkd7 415 45 2 2 CD cord-259669-fod4xkd7 415 46 DNA dna NN cord-259669-fod4xkd7 415 47 Reading read VBG cord-259669-fod4xkd7 415 48 the the DT cord-259669-fod4xkd7 415 49 viral viral JJ cord-259669-fod4xkd7 415 50 signature signature NN cord-259669-fod4xkd7 415 51 by by IN cord-259669-fod4xkd7 415 52 Tolllike Tolllike NNP cord-259669-fod4xkd7 415 53 receptors receptor NNS cord-259669-fod4xkd7 415 54 and and CC cord-259669-fod4xkd7 415 55 other other JJ cord-259669-fod4xkd7 415 56 pattern pattern NN cord-259669-fod4xkd7 415 57 recognition recognition NN cord-259669-fod4xkd7 415 58 receptors receptor NNS cord-259669-fod4xkd7 416 1 Beyond beyond IN cord-259669-fod4xkd7 416 2 doublestranded doublestranded JJ cord-259669-fod4xkd7 416 3 RNAtype RNAtype NNS cord-259669-fod4xkd7 416 4 I -PRON- PRP cord-259669-fod4xkd7 416 5 IFN IFN NNP cord-259669-fod4xkd7 416 6 induction induction NN cord-259669-fod4xkd7 416 7 by by IN cord-259669-fod4xkd7 416 8 3pRNA 3prna CD cord-259669-fod4xkd7 416 9 and and CC cord-259669-fod4xkd7 416 10 other other JJ cord-259669-fod4xkd7 416 11 viral viral JJ cord-259669-fod4xkd7 416 12 nucleic nucleic JJ cord-259669-fod4xkd7 416 13 acids acid NNS cord-259669-fod4xkd7 417 1 The the DT cord-259669-fod4xkd7 417 2 role role NN cord-259669-fod4xkd7 417 3 of of IN cord-259669-fod4xkd7 417 4 viral viral JJ cord-259669-fod4xkd7 417 5 nucleic nucleic JJ cord-259669-fod4xkd7 417 6 acid acid NN cord-259669-fod4xkd7 417 7 recognition recognition NN cord-259669-fod4xkd7 417 8 in in IN cord-259669-fod4xkd7 417 9 dendritic dendritic JJ cord-259669-fod4xkd7 417 10 cells cell NNS cord-259669-fod4xkd7 417 11 for for IN cord-259669-fod4xkd7 417 12 innate innate JJ cord-259669-fod4xkd7 417 13 and and CC cord-259669-fod4xkd7 417 14 adaptive adaptive JJ cord-259669-fod4xkd7 417 15 antiviral antiviral JJ cord-259669-fod4xkd7 417 16 immunity immunity NN cord-259669-fod4xkd7 417 17 Subset subset NN cord-259669-fod4xkd7 417 18 - - HYPH cord-259669-fod4xkd7 417 19 dependent dependent JJ cord-259669-fod4xkd7 417 20 modulation modulation NN cord-259669-fod4xkd7 417 21 of of IN cord-259669-fod4xkd7 417 22 dendritic dendritic JJ cord-259669-fod4xkd7 417 23 cell cell NN cord-259669-fod4xkd7 417 24 activity activity NN cord-259669-fod4xkd7 417 25 by by IN cord-259669-fod4xkd7 417 26 circovirus circovirus NNP cord-259669-fod4xkd7 417 27 type type NN cord-259669-fod4xkd7 417 28 2 2 CD cord-259669-fod4xkd7 417 29 Natural natural JJ cord-259669-fod4xkd7 417 30 interferon interferon NN cord-259669-fod4xkd7 417 31 - - HYPH cord-259669-fod4xkd7 417 32 alpha alpha NN cord-259669-fod4xkd7 417 33 producing producing NN cord-259669-fod4xkd7 417 34 cells cell NNS cord-259669-fod4xkd7 417 35 : : : cord-259669-fod4xkd7 417 36 the the DT cord-259669-fod4xkd7 417 37 plasmacytoid plasmacytoid NNP cord-259669-fod4xkd7 417 38 dendritic dendritic JJ cord-259669-fod4xkd7 417 39 cells cell NNS cord-259669-fod4xkd7 418 1 IRF-7 IRF-7 NNP cord-259669-fod4xkd7 418 2 is be VBZ cord-259669-fod4xkd7 418 3 the the DT cord-259669-fod4xkd7 418 4 master master NN cord-259669-fod4xkd7 418 5 regulator regulator NN cord-259669-fod4xkd7 418 6 of of IN cord-259669-fod4xkd7 418 7 type type NN cord-259669-fod4xkd7 419 1 -I -i WDT cord-259669-fod4xkd7 419 2 interferondependent interferondependent NN cord-259669-fod4xkd7 419 3 immune immune JJ cord-259669-fod4xkd7 419 4 responses response NNS cord-259669-fod4xkd7 420 1 Classical classical JJ cord-259669-fod4xkd7 420 2 swine swine NN cord-259669-fod4xkd7 420 3 fever fever NN cord-259669-fod4xkd7 420 4 virus virus NN cord-259669-fod4xkd7 420 5 Npro Npro NNP cord-259669-fod4xkd7 420 6 interacts interact VBZ cord-259669-fod4xkd7 420 7 with with IN cord-259669-fod4xkd7 420 8 interferon interferon NN cord-259669-fod4xkd7 420 9 regulatory regulatory JJ cord-259669-fod4xkd7 420 10 factor factor NN cord-259669-fod4xkd7 420 11 3 3 CD cord-259669-fod4xkd7 420 12 and and CC cord-259669-fod4xkd7 420 13 induces induce VBZ cord-259669-fod4xkd7 420 14 its -PRON- PRP$ cord-259669-fod4xkd7 420 15 proteasomal proteasomal JJ cord-259669-fod4xkd7 420 16 degradation degradation NN cord-259669-fod4xkd7 420 17 Role role NN cord-259669-fod4xkd7 420 18 of of IN cord-259669-fod4xkd7 420 19 doublestranded doublestranded NNP cord-259669-fod4xkd7 420 20 RNA RNA NNP cord-259669-fod4xkd7 420 21 and and CC cord-259669-fod4xkd7 420 22 N(pro N(pro NNP cord-259669-fod4xkd7 420 23 ) ) -RRB- cord-259669-fod4xkd7 420 24 of of IN cord-259669-fod4xkd7 420 25 classical classical JJ cord-259669-fod4xkd7 420 26 swine swine NN cord-259669-fod4xkd7 420 27 fever fever NN cord-259669-fod4xkd7 420 28 virus virus NN cord-259669-fod4xkd7 420 29 in in IN cord-259669-fod4xkd7 420 30 the the DT cord-259669-fod4xkd7 420 31 activation activation NN cord-259669-fod4xkd7 420 32 of of IN cord-259669-fod4xkd7 420 33 monocyte monocyte NNP cord-259669-fod4xkd7 420 34 - - HYPH cord-259669-fod4xkd7 420 35 derived derive VBN cord-259669-fod4xkd7 420 36 dendritic dendritic JJ cord-259669-fod4xkd7 420 37 cells cell NNS cord-259669-fod4xkd7 420 38 High high JJ cord-259669-fod4xkd7 420 39 IFNalpha ifnalpha NN cord-259669-fod4xkd7 420 40 responses response NNS cord-259669-fod4xkd7 420 41 associated associate VBN cord-259669-fod4xkd7 420 42 with with IN cord-259669-fod4xkd7 420 43 depletion depletion NN cord-259669-fod4xkd7 420 44 of of IN cord-259669-fod4xkd7 420 45 lymphocytes lymphocyte NNS cord-259669-fod4xkd7 420 46 and and CC cord-259669-fod4xkd7 420 47 natural natural JJ cord-259669-fod4xkd7 420 48 IFNproducing ifnproducing NN cord-259669-fod4xkd7 420 49 cells cell NNS cord-259669-fod4xkd7 420 50 during during IN cord-259669-fod4xkd7 420 51 classical classical JJ cord-259669-fod4xkd7 420 52 swine swine NN cord-259669-fod4xkd7 420 53 fever fever NN cord-259669-fod4xkd7 421 1 Classical classical JJ cord-259669-fod4xkd7 421 2 swine swine NN cord-259669-fod4xkd7 421 3 fever fever NN cord-259669-fod4xkd7 421 4 virus virus NN cord-259669-fod4xkd7 421 5 induces induce VBZ cord-259669-fod4xkd7 421 6 activation activation NN cord-259669-fod4xkd7 421 7 of of IN cord-259669-fod4xkd7 421 8 plasmacytoid plasmacytoid NNP cord-259669-fod4xkd7 421 9 and and CC cord-259669-fod4xkd7 421 10 conventional conventional JJ cord-259669-fod4xkd7 421 11 dendritic dendritic JJ cord-259669-fod4xkd7 421 12 cells cell NNS cord-259669-fod4xkd7 421 13 in in IN cord-259669-fod4xkd7 421 14 tonsil tonsil NN cord-259669-fod4xkd7 421 15 , , , cord-259669-fod4xkd7 421 16 blood blood NN cord-259669-fod4xkd7 421 17 , , , cord-259669-fod4xkd7 421 18 and and CC cord-259669-fod4xkd7 421 19 spleen spleen NNS cord-259669-fod4xkd7 421 20 of of IN cord-259669-fod4xkd7 421 21 infected infected JJ cord-259669-fod4xkd7 421 22 pigs pig NNS cord-259669-fod4xkd7 421 23 The the DT cord-259669-fod4xkd7 421 24 virus virus NN cord-259669-fod4xkd7 421 25 battles battle NNS cord-259669-fod4xkd7 421 26 : : : cord-259669-fod4xkd7 421 27 IFN IFN NNP cord-259669-fod4xkd7 421 28 induction induction NN cord-259669-fod4xkd7 421 29 of of IN cord-259669-fod4xkd7 421 30 the the DT cord-259669-fod4xkd7 421 31 antiviral antiviral JJ cord-259669-fod4xkd7 421 32 state state NN cord-259669-fod4xkd7 421 33 and and CC cord-259669-fod4xkd7 421 34 mechanisms mechanism NNS cord-259669-fod4xkd7 421 35 of of IN cord-259669-fod4xkd7 421 36 viral viral JJ cord-259669-fod4xkd7 421 37 evasion evasion NN cord-259669-fod4xkd7 421 38 Phenotypic phenotypic JJ cord-259669-fod4xkd7 421 39 and and CC cord-259669-fod4xkd7 421 40 functional functional JJ cord-259669-fod4xkd7 421 41 modulation modulation NN cord-259669-fod4xkd7 421 42 of of IN cord-259669-fod4xkd7 421 43 bone bone NN cord-259669-fod4xkd7 421 44 marrowderived marrowderive VBN cord-259669-fod4xkd7 421 45 dendritic dendritic JJ cord-259669-fod4xkd7 421 46 cells cell NNS cord-259669-fod4xkd7 421 47 by by IN cord-259669-fod4xkd7 421 48 porcine porcine JJ cord-259669-fod4xkd7 421 49 reproductive reproductive JJ cord-259669-fod4xkd7 421 50 and and CC cord-259669-fod4xkd7 421 51 respiratory respiratory JJ cord-259669-fod4xkd7 421 52 syndrome syndrome NN cord-259669-fod4xkd7 421 53 virus virus NN cord-259669-fod4xkd7 421 54 Porcine porcine JJ cord-259669-fod4xkd7 421 55 reproductive reproductive JJ cord-259669-fod4xkd7 421 56 and and CC cord-259669-fod4xkd7 421 57 respiratory respiratory JJ cord-259669-fod4xkd7 421 58 syndrome syndrome NN cord-259669-fod4xkd7 421 59 virus virus NN cord-259669-fod4xkd7 421 60 productively productively RB cord-259669-fod4xkd7 421 61 infects infect VBZ cord-259669-fod4xkd7 421 62 monocyte monocyte NNP cord-259669-fod4xkd7 421 63 - - HYPH cord-259669-fod4xkd7 421 64 derived derive VBN cord-259669-fod4xkd7 421 65 dendritic dendritic JJ cord-259669-fod4xkd7 421 66 cells cell NNS cord-259669-fod4xkd7 421 67 and and CC cord-259669-fod4xkd7 421 68 compromises compromise VBZ cord-259669-fod4xkd7 421 69 their -PRON- PRP$ cord-259669-fod4xkd7 421 70 antigen antigen NN cord-259669-fod4xkd7 421 71 - - HYPH cord-259669-fod4xkd7 421 72 presenting present VBG cord-259669-fod4xkd7 421 73 ability ability NN cord-259669-fod4xkd7 421 74 Effects effect NNS cord-259669-fod4xkd7 421 75 of of IN cord-259669-fod4xkd7 421 76 porcine porcine JJ cord-259669-fod4xkd7 421 77 reproductive reproductive JJ cord-259669-fod4xkd7 421 78 and and CC cord-259669-fod4xkd7 421 79 respiratory respiratory JJ cord-259669-fod4xkd7 421 80 syndrome syndrome NN cord-259669-fod4xkd7 421 81 virus virus NN cord-259669-fod4xkd7 421 82 - - HYPH cord-259669-fod4xkd7 421 83 infected infect VBN cord-259669-fod4xkd7 421 84 antigen antigen NN cord-259669-fod4xkd7 421 85 - - HYPH cord-259669-fod4xkd7 421 86 presenting present VBG cord-259669-fod4xkd7 421 87 cells cell NNS cord-259669-fod4xkd7 421 88 on on IN cord-259669-fod4xkd7 421 89 Tcell Tcell NNP cord-259669-fod4xkd7 421 90 activation activation NN cord-259669-fod4xkd7 421 91 and and CC cord-259669-fod4xkd7 421 92 antiviral antiviral JJ cord-259669-fod4xkd7 421 93 cytokine cytokine NN cord-259669-fod4xkd7 421 94 production production NN cord-259669-fod4xkd7 421 95 Differential differential NN cord-259669-fod4xkd7 421 96 type type NN cord-259669-fod4xkd7 422 1 I -PRON- PRP cord-259669-fod4xkd7 422 2 interferon interferon RB cord-259669-fod4xkd7 422 3 activation activation NN cord-259669-fod4xkd7 422 4 and and CC cord-259669-fod4xkd7 422 5 susceptibility susceptibility NN cord-259669-fod4xkd7 422 6 of of IN cord-259669-fod4xkd7 422 7 dendritic dendritic JJ cord-259669-fod4xkd7 422 8 cell cell NN cord-259669-fod4xkd7 422 9 populations population NNS cord-259669-fod4xkd7 422 10 to to IN cord-259669-fod4xkd7 422 11 porcine porcine JJ cord-259669-fod4xkd7 422 12 arterivirus arterivirus NN cord-259669-fod4xkd7 422 13 Coronavirus Coronavirus NNP cord-259669-fod4xkd7 422 14 pseudoparticles pseudoparticle NNS cord-259669-fod4xkd7 422 15 formed form VBN cord-259669-fod4xkd7 422 16 with with IN cord-259669-fod4xkd7 422 17 recombinant recombinant JJ cord-259669-fod4xkd7 422 18 M M NNP cord-259669-fod4xkd7 422 19 and and CC cord-259669-fod4xkd7 422 20 E e NN cord-259669-fod4xkd7 422 21 proteins protein NNS cord-259669-fod4xkd7 422 22 induce induce VBP cord-259669-fod4xkd7 422 23 alpha alpha NN cord-259669-fod4xkd7 422 24 interferon interferon NN cord-259669-fod4xkd7 422 25 synthesis synthesis NN cord-259669-fod4xkd7 422 26 by by IN cord-259669-fod4xkd7 422 27 leukocytes leukocyte NNS cord-259669-fod4xkd7 422 28 Interferon Interferon NNP cord-259669-fod4xkd7 422 29 alpha alpha NN cord-259669-fod4xkd7 422 30 inducing induce VBG cord-259669-fod4xkd7 422 31 property property NN cord-259669-fod4xkd7 422 32 of of IN cord-259669-fod4xkd7 422 33 coronavirus coronavirus NN cord-259669-fod4xkd7 422 34 particles particle NNS cord-259669-fod4xkd7 422 35 and and CC cord-259669-fod4xkd7 422 36 pseudoparticles pseudoparticle NNS cord-259669-fod4xkd7 422 37 Single single JJ cord-259669-fod4xkd7 422 38 amino amino NN cord-259669-fod4xkd7 422 39 acid acid NN cord-259669-fod4xkd7 422 40 changes change NNS cord-259669-fod4xkd7 422 41 in in IN cord-259669-fod4xkd7 422 42 the the DT cord-259669-fod4xkd7 422 43 viral viral JJ cord-259669-fod4xkd7 422 44 glycoprotein glycoprotein NN cord-259669-fod4xkd7 422 45 M m CD cord-259669-fod4xkd7 422 46 affect affect NN cord-259669-fod4xkd7 422 47 induction induction NN cord-259669-fod4xkd7 422 48 of of IN cord-259669-fod4xkd7 422 49 alpha alpha NN cord-259669-fod4xkd7 422 50 interferon interferon NN cord-259669-fod4xkd7 422 51 by by IN cord-259669-fod4xkd7 422 52 the the DT cord-259669-fod4xkd7 422 53 coronavirus coronavirus NN cord-259669-fod4xkd7 422 54 transmissible transmissible JJ cord-259669-fod4xkd7 422 55 gastroenteritis gastroenteritis NN cord-259669-fod4xkd7 422 56 virus virus NN cord-259669-fod4xkd7 422 57 Human human JJ cord-259669-fod4xkd7 422 58 immunodeficiency immunodeficiency NN cord-259669-fod4xkd7 422 59 virus virus NN cord-259669-fod4xkd7 422 60 type type NN cord-259669-fod4xkd7 422 61 1 1 CD cord-259669-fod4xkd7 422 62 gp120 gp120 CD cord-259669-fod4xkd7 422 63 and and CC cord-259669-fod4xkd7 423 1 other other JJ cord-259669-fod4xkd7 423 2 activation activation NN cord-259669-fod4xkd7 423 3 stimuli stimulus NNS cord-259669-fod4xkd7 423 4 are be VBP cord-259669-fod4xkd7 423 5 highly highly RB cord-259669-fod4xkd7 423 6 effective effective JJ cord-259669-fod4xkd7 423 7 in in IN cord-259669-fod4xkd7 423 8 triggering trigger VBG cord-259669-fod4xkd7 423 9 alpha alpha NN cord-259669-fod4xkd7 423 10 interferon interferon NN cord-259669-fod4xkd7 423 11 and and CC cord-259669-fod4xkd7 423 12 CC CC NNP cord-259669-fod4xkd7 423 13 chemokine chemokine NN cord-259669-fod4xkd7 423 14 production production NN cord-259669-fod4xkd7 423 15 in in IN cord-259669-fod4xkd7 423 16 circulating circulate VBG cord-259669-fod4xkd7 423 17 plasmacytoid plasmacytoid NNP cord-259669-fod4xkd7 423 18 but but CC cord-259669-fod4xkd7 423 19 not not RB cord-259669-fod4xkd7 423 20 myeloid myeloid JJ cord-259669-fod4xkd7 423 21 dendritic dendritic JJ cord-259669-fod4xkd7 423 22 cells cell NNS cord-259669-fod4xkd7 423 23 Constitutive constitutive JJ cord-259669-fod4xkd7 423 24 expression expression NN cord-259669-fod4xkd7 423 25 of of IN cord-259669-fod4xkd7 423 26 alpha alpha NN cord-259669-fod4xkd7 423 27 interferon interferon NN cord-259669-fod4xkd7 423 28 by by IN cord-259669-fod4xkd7 423 29 skin skin NN cord-259669-fod4xkd7 423 30 dendritic dendritic JJ cord-259669-fod4xkd7 423 31 cells cell NNS cord-259669-fod4xkd7 423 32 confers confer VBZ cord-259669-fod4xkd7 423 33 resistance resistance NN cord-259669-fod4xkd7 423 34 to to IN cord-259669-fod4xkd7 423 35 infection infection NN cord-259669-fod4xkd7 423 36 by by IN cord-259669-fod4xkd7 423 37 foot foot NN cord-259669-fod4xkd7 423 38 - - HYPH cord-259669-fod4xkd7 423 39 andmouth andmouth NN cord-259669-fod4xkd7 423 40 disease disease NN cord-259669-fod4xkd7 423 41 virus virus NN cord-259669-fod4xkd7 423 42 Dendritic dendritic JJ cord-259669-fod4xkd7 423 43 cells cell NNS cord-259669-fod4xkd7 423 44 internalisation internalisation NN cord-259669-fod4xkd7 423 45 of of IN cord-259669-fod4xkd7 423 46 foot foot NN cord-259669-fod4xkd7 423 47 - - HYPH cord-259669-fod4xkd7 423 48 and and CC cord-259669-fod4xkd7 423 49 - - HYPH cord-259669-fod4xkd7 423 50 mouth mouth NN cord-259669-fod4xkd7 423 51 disease disease NN cord-259669-fod4xkd7 423 52 virus virus NN cord-259669-fod4xkd7 423 53 : : : cord-259669-fod4xkd7 423 54 influence influence NN cord-259669-fod4xkd7 423 55 of of IN cord-259669-fod4xkd7 423 56 heparin heparin NN cord-259669-fod4xkd7 423 57 sulphate sulphate NN cord-259669-fod4xkd7 423 58 binding bind VBG cord-259669-fod4xkd7 423 59 on on IN cord-259669-fod4xkd7 423 60 virus virus NN cord-259669-fod4xkd7 423 61 uptake uptake NN cord-259669-fod4xkd7 423 62 and and CC cord-259669-fod4xkd7 423 63 immune immune JJ cord-259669-fod4xkd7 423 64 response response NN cord-259669-fod4xkd7 423 65 induction induction NN cord-259669-fod4xkd7 424 1 Innate innate JJ cord-259669-fod4xkd7 424 2 immune immune JJ cord-259669-fod4xkd7 424 3 responses response NNS cord-259669-fod4xkd7 424 4 against against IN cord-259669-fod4xkd7 424 5 foot foot NN cord-259669-fod4xkd7 424 6 - - HYPH cord-259669-fod4xkd7 424 7 and and CC cord-259669-fod4xkd7 424 8 - - HYPH cord-259669-fod4xkd7 424 9 mouth mouth NN cord-259669-fod4xkd7 424 10 disease disease NN cord-259669-fod4xkd7 424 11 virus virus NN cord-259669-fod4xkd7 424 12 : : : cord-259669-fod4xkd7 424 13 current current JJ cord-259669-fod4xkd7 424 14 understanding understanding NN cord-259669-fod4xkd7 424 15 and and CC cord-259669-fod4xkd7 424 16 future future JJ cord-259669-fod4xkd7 424 17 directions direction NNS cord-259669-fod4xkd7 424 18 Interferon interferon NN cord-259669-fod4xkd7 424 19 - - HYPH cord-259669-fod4xkd7 424 20 alpha alpha NN cord-259669-fod4xkd7 424 21 production production NN cord-259669-fod4xkd7 424 22 by by IN cord-259669-fod4xkd7 424 23 swine swine NN cord-259669-fod4xkd7 424 24 dendritic dendritic JJ cord-259669-fod4xkd7 424 25 cells cell NNS cord-259669-fod4xkd7 424 26 is be VBZ cord-259669-fod4xkd7 424 27 inhibited inhibit VBN cord-259669-fod4xkd7 424 28 during during IN cord-259669-fod4xkd7 424 29 acute acute JJ cord-259669-fod4xkd7 424 30 infection infection NN cord-259669-fod4xkd7 424 31 with with IN cord-259669-fod4xkd7 424 32 footand footand NN cord-259669-fod4xkd7 424 33 - - HYPH cord-259669-fod4xkd7 424 34 mouth mouth NN cord-259669-fod4xkd7 424 35 disease disease NN cord-259669-fod4xkd7 424 36 virus virus NN cord-259669-fod4xkd7 424 37 Porcine porcine JJ cord-259669-fod4xkd7 424 38 reproductive reproductive JJ cord-259669-fod4xkd7 424 39 and and CC cord-259669-fod4xkd7 424 40 respiratory respiratory JJ cord-259669-fod4xkd7 424 41 syndrome syndrome NN cord-259669-fod4xkd7 424 42 ( ( -LRB- cord-259669-fod4xkd7 424 43 PRRS PRRS NNP cord-259669-fod4xkd7 424 44 ) ) -RRB- cord-259669-fod4xkd7 425 1 virus virus NN cord-259669-fod4xkd7 425 2 - - HYPH cord-259669-fod4xkd7 425 3 specific specific JJ cord-259669-fod4xkd7 425 4 interferongamma(+ interferongamma(+ NNP cord-259669-fod4xkd7 425 5 ) ) -RRB- cord-259669-fod4xkd7 426 1 T t NN cord-259669-fod4xkd7 426 2 - - HYPH cord-259669-fod4xkd7 426 3 cell cell NN cord-259669-fod4xkd7 426 4 responses response NNS cord-259669-fod4xkd7 426 5 after after IN cord-259669-fod4xkd7 426 6 PRRS PRRS NNP cord-259669-fod4xkd7 426 7 virus virus NN cord-259669-fod4xkd7 426 8 infection infection NN cord-259669-fod4xkd7 426 9 or or CC cord-259669-fod4xkd7 426 10 vaccination vaccination NN cord-259669-fod4xkd7 426 11 with with IN cord-259669-fod4xkd7 426 12 an an DT cord-259669-fod4xkd7 426 13 inactivated inactivate VBN cord-259669-fod4xkd7 426 14 PRRS PRRS NNP cord-259669-fod4xkd7 426 15 vaccine vaccine NN cord-259669-fod4xkd7 426 16 Identification identification NN cord-259669-fod4xkd7 426 17 of of IN cord-259669-fod4xkd7 426 18 classical classical JJ cord-259669-fod4xkd7 426 19 swine swine NN cord-259669-fod4xkd7 426 20 fever fever NN cord-259669-fod4xkd7 426 21 virus virus NN cord-259669-fod4xkd7 426 22 protein protein NN cord-259669-fod4xkd7 426 23 E2 E2 NNP cord-259669-fod4xkd7 426 24 as as IN cord-259669-fod4xkd7 426 25 a a DT cord-259669-fod4xkd7 426 26 target target NN cord-259669-fod4xkd7 426 27 for for IN cord-259669-fod4xkd7 426 28 cytotoxic cytotoxic JJ cord-259669-fod4xkd7 426 29 T t NN cord-259669-fod4xkd7 426 30 cells cell NNS cord-259669-fod4xkd7 426 31 by by IN cord-259669-fod4xkd7 426 32 using use VBG cord-259669-fod4xkd7 426 33 mRNAtransfected mrnatransfected JJ cord-259669-fod4xkd7 426 34 antigen antigen NN cord-259669-fod4xkd7 426 35 - - HYPH cord-259669-fod4xkd7 426 36 presenting present VBG cord-259669-fod4xkd7 426 37 cells cell NNS cord-259669-fod4xkd7 426 38 Porcine porcine JJ cord-259669-fod4xkd7 426 39 reproductive reproductive JJ cord-259669-fod4xkd7 426 40 and and CC cord-259669-fod4xkd7 426 41 respiratory respiratory JJ cord-259669-fod4xkd7 426 42 syndrome syndrome NN cord-259669-fod4xkd7 426 43 virus virus NN cord-259669-fod4xkd7 426 44 ( ( -LRB- cord-259669-fod4xkd7 426 45 PRRSV PRRSV NNP cord-259669-fod4xkd7 426 46 ) ) -RRB- cord-259669-fod4xkd7 426 47 infects infect VBZ cord-259669-fod4xkd7 426 48 mature mature JJ cord-259669-fod4xkd7 426 49 porcine porcine JJ cord-259669-fod4xkd7 426 50 dendritic dendritic JJ cord-259669-fod4xkd7 426 51 cells cell NNS cord-259669-fod4xkd7 426 52 and and CC cord-259669-fod4xkd7 426 53 upregulates upregulate VBZ cord-259669-fod4xkd7 426 54 IL-10 IL-10 NNP cord-259669-fod4xkd7 426 55 production production NN cord-259669-fod4xkd7 426 56 Mycoplasma mycoplasma NN cord-259669-fod4xkd7 426 57 contamination contamination NN cord-259669-fod4xkd7 426 58 and and CC cord-259669-fod4xkd7 426 59 viral viral JJ cord-259669-fod4xkd7 426 60 immunomodulatory immunomodulatory JJ cord-259669-fod4xkd7 426 61 activity activity NN cord-259669-fod4xkd7 426 62 : : : cord-259669-fod4xkd7 426 63 dendritic dendritic JJ cord-259669-fod4xkd7 426 64 cells cell NNS cord-259669-fod4xkd7 426 65 open open VBP cord-259669-fod4xkd7 426 66 Pandora Pandora NNP cord-259669-fod4xkd7 426 67 's 's POS cord-259669-fod4xkd7 426 68 box box NN cord-259669-fod4xkd7 426 69 Efficient efficient JJ cord-259669-fod4xkd7 426 70 transgenesis transgenesis NN cord-259669-fod4xkd7 426 71 in in IN cord-259669-fod4xkd7 426 72 farm farm NN cord-259669-fod4xkd7 426 73 animals animal NNS cord-259669-fod4xkd7 426 74 by by IN cord-259669-fod4xkd7 426 75 lentiviral lentiviral JJ cord-259669-fod4xkd7 426 76 vectors vector NNS cord-259669-fod4xkd7 426 77 Phenotype Phenotype NNP cord-259669-fod4xkd7 426 78 of of IN cord-259669-fod4xkd7 426 79 porcine porcine JJ cord-259669-fod4xkd7 426 80 monocytic monocytic JJ cord-259669-fod4xkd7 426 81 cells cell NNS cord-259669-fod4xkd7 426 82 : : : cord-259669-fod4xkd7 426 83 modulation modulation NN cord-259669-fod4xkd7 426 84 of of IN cord-259669-fod4xkd7 426 85 surface surface NN cord-259669-fod4xkd7 426 86 molecule molecule NN cord-259669-fod4xkd7 426 87 expression expression NN cord-259669-fod4xkd7 426 88 upon upon IN cord-259669-fod4xkd7 426 89 monocyte monocyte NNP cord-259669-fod4xkd7 426 90 differentiation differentiation NN cord-259669-fod4xkd7 426 91 into into IN cord-259669-fod4xkd7 426 92 macrophages macrophage NNS cord-259669-fod4xkd7 426 93 Molecular molecular JJ cord-259669-fod4xkd7 426 94 cloning cloning NN cord-259669-fod4xkd7 426 95 and and CC cord-259669-fod4xkd7 426 96 characterization characterization NN cord-259669-fod4xkd7 426 97 of of IN cord-259669-fod4xkd7 426 98 a a DT cord-259669-fod4xkd7 426 99 novel novel JJ cord-259669-fod4xkd7 426 100 CD1 CD1 NNP cord-259669-fod4xkd7 426 101 gene gene NN cord-259669-fod4xkd7 426 102 from from IN cord-259669-fod4xkd7 426 103 the the DT cord-259669-fod4xkd7 426 104 pig pig NN cord-259669-fod4xkd7 427 1 Innate innate JJ cord-259669-fod4xkd7 427 2 immune immune JJ cord-259669-fod4xkd7 427 3 responses response NNS cord-259669-fod4xkd7 427 4 following follow VBG cord-259669-fod4xkd7 427 5 emergency emergency NN cord-259669-fod4xkd7 427 6 vaccination vaccination NN cord-259669-fod4xkd7 427 7 against against IN cord-259669-fod4xkd7 427 8 foot foot NN cord-259669-fod4xkd7 427 9 - - HYPH cord-259669-fod4xkd7 427 10 andmouth andmouth NNP cord-259669-fod4xkd7 427 11 disease disease NN cord-259669-fod4xkd7 427 12 virus virus NN cord-259669-fod4xkd7 427 13 in in IN cord-259669-fod4xkd7 427 14 pigs pig NNS cord-259669-fod4xkd7 428 1 The the DT cord-259669-fod4xkd7 428 2 Fusarium fusarium NN cord-259669-fod4xkd7 428 3 toxin toxin NN cord-259669-fod4xkd7 428 4 deoxynivalenol deoxynivalenol NN cord-259669-fod4xkd7 428 5 disrupts disrupt VBZ cord-259669-fod4xkd7 428 6 phenotype phenotype NN cord-259669-fod4xkd7 428 7 and and CC cord-259669-fod4xkd7 428 8 function function NN cord-259669-fod4xkd7 428 9 of of IN cord-259669-fod4xkd7 428 10 monocyte monocyte NNP cord-259669-fod4xkd7 428 11 - - HYPH cord-259669-fod4xkd7 428 12 derived derive VBN cord-259669-fod4xkd7 428 13 dendritic dendritic JJ cord-259669-fod4xkd7 428 14 cells cell NNS cord-259669-fod4xkd7 428 15 in in IN cord-259669-fod4xkd7 428 16 vivo vivo NN cord-259669-fod4xkd7 428 17 and and CC cord-259669-fod4xkd7 429 1 in in FW cord-259669-fod4xkd7 429 2 vitro vitro FW cord-259669-fod4xkd7 429 3 Dendritic dendritic JJ cord-259669-fod4xkd7 429 4 cells cell NNS cord-259669-fod4xkd7 429 5 harbor harbor VBP cord-259669-fod4xkd7 429 6 infectious infectious JJ cord-259669-fod4xkd7 429 7 porcine porcine JJ cord-259669-fod4xkd7 429 8 circovirus circovirus NN cord-259669-fod4xkd7 429 9 type type NN cord-259669-fod4xkd7 429 10 2 2 CD cord-259669-fod4xkd7 429 11 in in IN cord-259669-fod4xkd7 429 12 the the DT cord-259669-fod4xkd7 429 13 absence absence NN cord-259669-fod4xkd7 429 14 of of IN cord-259669-fod4xkd7 429 15 apparent apparent JJ cord-259669-fod4xkd7 429 16 cell cell NN cord-259669-fod4xkd7 429 17 modulation modulation NN cord-259669-fod4xkd7 429 18 or or CC cord-259669-fod4xkd7 429 19 replication replication NN cord-259669-fod4xkd7 429 20 of of IN cord-259669-fod4xkd7 429 21 the the DT cord-259669-fod4xkd7 429 22 virus virus NN