id	sid	tid	token	lemma	pos
cord-275433-58unu79x	1	1	key	key	JJ
cord-275433-58unu79x	1	2	:	:	:
cord-275433-58unu79x	1	3	cord-275433	cord-275433	ADD
cord-275433-58unu79x	1	4	-	-	HYPH
cord-275433-58unu79x	1	5	58unu79x	58unu79x	CD
cord-275433-58unu79x	1	6	authors	author	NNS
cord-275433-58unu79x	1	7	:	:	:
cord-275433-58unu79x	1	8	Levine	Levine	NNP
cord-275433-58unu79x	1	9	,	,	,
cord-275433-58unu79x	1	10	Beth	Beth	NNP
cord-275433-58unu79x	1	11	;	;	:
cord-275433-58unu79x	1	12	Deretic	Deretic	NNP
cord-275433-58unu79x	1	13	,	,	,
cord-275433-58unu79x	1	14	Vojo	Vojo	NNP
cord-275433-58unu79x	2	1	title	title	NN
cord-275433-58unu79x	2	2	:	:	:
cord-275433-58unu79x	3	1	Unveiling	unveil	VBG
cord-275433-58unu79x	3	2	the	the	DT
cord-275433-58unu79x	3	3	roles	role	NNS
cord-275433-58unu79x	3	4	of	of	IN
cord-275433-58unu79x	3	5	autophagy	autophagy	NN
cord-275433-58unu79x	3	6	in	in	IN
cord-275433-58unu79x	3	7	innate	innate	JJ
cord-275433-58unu79x	3	8	and	and	CC
cord-275433-58unu79x	3	9	adaptive	adaptive	JJ
cord-275433-58unu79x	3	10	immunity	immunity	NN
cord-275433-58unu79x	3	11	date	date	NN
cord-275433-58unu79x	3	12	:	:	:
cord-275433-58unu79x	4	1	2007	2007	CD
cord-275433-58unu79x	4	2	journal	journal	NNP
cord-275433-58unu79x	4	3	:	:	:
cord-275433-58unu79x	5	1	Nat	Nat	NNP
cord-275433-58unu79x	5	2	Rev	Rev	NNP
cord-275433-58unu79x	5	3	Immunol	Immunol	NNP
cord-275433-58unu79x	5	4	DOI	DOI	NNP
cord-275433-58unu79x	5	5	:	:	:
cord-275433-58unu79x	5	6	10.1038/	10.1038/	CD
cord-275433-58unu79x	6	1	nri2161	nri2161	NNP
cord-275433-58unu79x	6	2	sha	sha	NNP
cord-275433-58unu79x	6	3	:	:	:
cord-275433-58unu79x	7	1	24fac2ba81f1a4ab30fab3a6b29cdcbc66e8b499	24fac2ba81f1a4ab30fab3a6b29cdcbc66e8b499	NNP
cord-275433-58unu79x	7	2	doc_id	doc_id	NNPS
cord-275433-58unu79x	7	3	:	:	:
cord-275433-58unu79x	7	4	275433	275433	CD
cord-275433-58unu79x	7	5	cord_uid	cord_uid	NNS
cord-275433-58unu79x	7	6	:	:	:
cord-275433-58unu79x	8	1	58unu79x	58unu79x	CD
cord-275433-58unu79x	8	2	Cells	cell	NNS
cord-275433-58unu79x	8	3	digest	digest	VBP
cord-275433-58unu79x	8	4	portions	portion	NNS
cord-275433-58unu79x	8	5	of	of	IN
cord-275433-58unu79x	8	6	their	-PRON-	PRP$
cord-275433-58unu79x	8	7	interiors	interior	NNS
cord-275433-58unu79x	8	8	in	in	IN
cord-275433-58unu79x	8	9	a	a	DT
cord-275433-58unu79x	8	10	process	process	NN
cord-275433-58unu79x	8	11	known	know	VBN
cord-275433-58unu79x	8	12	as	as	IN
cord-275433-58unu79x	8	13	autophagy	autophagy	NN
cord-275433-58unu79x	8	14	to	to	TO
cord-275433-58unu79x	8	15	recycle	recycle	VB
cord-275433-58unu79x	8	16	nutrients	nutrient	NNS
cord-275433-58unu79x	8	17	,	,	,
cord-275433-58unu79x	8	18	remodel	remodel	VB
cord-275433-58unu79x	8	19	and	and	CC
cord-275433-58unu79x	8	20	dispose	dispose	VB
cord-275433-58unu79x	8	21	of	of	IN
cord-275433-58unu79x	8	22	unwanted	unwanted	JJ
cord-275433-58unu79x	8	23	cytoplasmic	cytoplasmic	JJ
cord-275433-58unu79x	8	24	constituents	constituent	NNS
cord-275433-58unu79x	8	25	.	.	.
cord-275433-58unu79x	9	1	This	this	DT
cord-275433-58unu79x	9	2	ancient	ancient	JJ
cord-275433-58unu79x	9	3	pathway	pathway	NN
cord-275433-58unu79x	9	4	,	,	,
cord-275433-58unu79x	9	5	conserved	conserve	VBN
cord-275433-58unu79x	9	6	from	from	IN
cord-275433-58unu79x	9	7	yeast	yeast	NN
cord-275433-58unu79x	9	8	to	to	IN
cord-275433-58unu79x	9	9	humans	human	NNS
cord-275433-58unu79x	9	10	,	,	,
cord-275433-58unu79x	9	11	is	be	VBZ
cord-275433-58unu79x	9	12	now	now	RB
cord-275433-58unu79x	9	13	emerging	emerge	VBG
cord-275433-58unu79x	9	14	as	as	IN
cord-275433-58unu79x	9	15	a	a	DT
cord-275433-58unu79x	9	16	central	central	JJ
cord-275433-58unu79x	9	17	player	player	NN
cord-275433-58unu79x	9	18	in	in	IN
cord-275433-58unu79x	9	19	the	the	DT
cord-275433-58unu79x	9	20	immunological	immunological	JJ
cord-275433-58unu79x	9	21	control	control	NN
cord-275433-58unu79x	9	22	of	of	IN
cord-275433-58unu79x	9	23	bacterial	bacterial	JJ
cord-275433-58unu79x	9	24	,	,	,
cord-275433-58unu79x	9	25	parasitic	parasitic	JJ
cord-275433-58unu79x	9	26	and	and	CC
cord-275433-58unu79x	9	27	viral	viral	JJ
cord-275433-58unu79x	9	28	infections	infection	NNS
cord-275433-58unu79x	9	29	.	.	.
cord-275433-58unu79x	10	1	The	the	DT
cord-275433-58unu79x	10	2	process	process	NN
cord-275433-58unu79x	10	3	of	of	IN
cord-275433-58unu79x	10	4	autophagy	autophagy	NN
cord-275433-58unu79x	10	5	may	may	MD
cord-275433-58unu79x	10	6	degrade	degrade	VB
cord-275433-58unu79x	10	7	intracellular	intracellular	JJ
cord-275433-58unu79x	10	8	pathogens	pathogen	NNS
cord-275433-58unu79x	10	9	,	,	,
cord-275433-58unu79x	10	10	deliver	deliver	VBP
cord-275433-58unu79x	10	11	endogenous	endogenous	JJ
cord-275433-58unu79x	10	12	antigens	antigen	NNS
cord-275433-58unu79x	10	13	to	to	IN
cord-275433-58unu79x	10	14	MHC	MHC	NNP
cord-275433-58unu79x	10	15	-	-	HYPH
cord-275433-58unu79x	10	16	class	class	NNP
cord-275433-58unu79x	10	17	-	-	HYPH
cord-275433-58unu79x	10	18	II	ii	NN
cord-275433-58unu79x	10	19	-	-	HYPH
cord-275433-58unu79x	10	20	loading	loading	NN
cord-275433-58unu79x	10	21	compartments	compartment	NNS
cord-275433-58unu79x	10	22	,	,	,
cord-275433-58unu79x	10	23	direct	direct	JJ
cord-275433-58unu79x	10	24	viral	viral	JJ
cord-275433-58unu79x	10	25	nucleic	nucleic	JJ
cord-275433-58unu79x	10	26	acids	acid	NNS
cord-275433-58unu79x	10	27	to	to	IN
cord-275433-58unu79x	10	28	Toll	toll	NN
cord-275433-58unu79x	10	29	-	-	HYPH
cord-275433-58unu79x	10	30	like	like	JJ
cord-275433-58unu79x	10	31	receptors	receptor	NNS
cord-275433-58unu79x	10	32	and	and	CC
cord-275433-58unu79x	10	33	regulate	regulate	VB
cord-275433-58unu79x	10	34	T	t	NN
cord-275433-58unu79x	10	35	-	-	HYPH
cord-275433-58unu79x	10	36	cell	cell	NN
cord-275433-58unu79x	10	37	homeostasis	homeostasis	NN
cord-275433-58unu79x	10	38	.	.	.
cord-275433-58unu79x	11	1	This	this	DT
cord-275433-58unu79x	11	2	Review	Review	NNP
cord-275433-58unu79x	11	3	describes	describe	VBZ
cord-275433-58unu79x	11	4	the	the	DT
cord-275433-58unu79x	11	5	mechanisms	mechanism	NNS
cord-275433-58unu79x	11	6	of	of	IN
cord-275433-58unu79x	11	7	autophagy	autophagy	NN
cord-275433-58unu79x	11	8	and	and	CC
cord-275433-58unu79x	11	9	highlights	highlight	VBZ
cord-275433-58unu79x	11	10	recent	recent	JJ
cord-275433-58unu79x	11	11	advances	advance	NNS
cord-275433-58unu79x	11	12	relevant	relevant	JJ
cord-275433-58unu79x	11	13	to	to	IN
cord-275433-58unu79x	11	14	the	the	DT
cord-275433-58unu79x	11	15	role	role	NN
cord-275433-58unu79x	11	16	of	of	IN
cord-275433-58unu79x	11	17	autophagy	autophagy	NN
cord-275433-58unu79x	11	18	in	in	IN
cord-275433-58unu79x	11	19	innate	innate	JJ
cord-275433-58unu79x	11	20	and	and	CC
cord-275433-58unu79x	11	21	adaptive	adaptive	JJ
cord-275433-58unu79x	11	22	immunity	immunity	NN
cord-275433-58unu79x	11	23	.	.	.
cord-275433-58unu79x	12	1	Our	-PRON-	PRP$
cord-275433-58unu79x	12	2	armamentarium	armamentarium	NN
cord-275433-58unu79x	12	3	for	for	IN
cord-275433-58unu79x	12	4	fighting	fight	VBG
cord-275433-58unu79x	12	5	intracellular	intracellular	JJ
cord-275433-58unu79x	12	6	pathogens	pathogen	NNS
cord-275433-58unu79x	12	7	includes	include	VBZ
cord-275433-58unu79x	12	8	multiple	multiple	JJ
cord-275433-58unu79x	12	9	facets	facet	NNS
cord-275433-58unu79x	12	10	of	of	IN
cord-275433-58unu79x	12	11	the	the	DT
cord-275433-58unu79x	12	12	innate	innate	JJ
cord-275433-58unu79x	12	13	and	and	CC
cord-275433-58unu79x	12	14	adaptive	adaptive	JJ
cord-275433-58unu79x	12	15	immune	immune	JJ
cord-275433-58unu79x	12	16	response	response	NN
cord-275433-58unu79x	12	17	.	.	.
cord-275433-58unu79x	13	1	In	in	IN
cord-275433-58unu79x	13	2	the	the	DT
cord-275433-58unu79x	13	3	past	past	JJ
cord-275433-58unu79x	13	4	few	few	JJ
cord-275433-58unu79x	13	5	decades	decade	NNS
cord-275433-58unu79x	13	6	,	,	,
cord-275433-58unu79x	13	7	we	-PRON-	PRP
cord-275433-58unu79x	13	8	have	have	VBP
cord-275433-58unu79x	13	9	witnessed	witness	VBN
cord-275433-58unu79x	13	10	an	an	DT
cord-275433-58unu79x	13	11	explosion	explosion	NN
cord-275433-58unu79x	13	12	in	in	IN
cord-275433-58unu79x	13	13	our	-PRON-	PRP$
cord-275433-58unu79x	13	14	understanding	understanding	NN
cord-275433-58unu79x	13	15	of	of	IN
cord-275433-58unu79x	13	16	the	the	DT
cord-275433-58unu79x	13	17	mechanisms	mechanism	NNS
cord-275433-58unu79x	13	18	underlying	underlie	VBG
cord-275433-58unu79x	13	19	antigen	antigen	NN
cord-275433-58unu79x	13	20	presentation	presentation	NN
cord-275433-58unu79x	13	21	,	,	,
cord-275433-58unu79x	13	22	immune	immune	JJ
cord-275433-58unu79x	13	23	recognition	recognition	NN
cord-275433-58unu79x	13	24	of	of	IN
cord-275433-58unu79x	13	25	infected	infected	JJ
cord-275433-58unu79x	13	26	cells	cell	NNS
cord-275433-58unu79x	13	27	,	,	,
cord-275433-58unu79x	13	28	cellular	cellular	JJ
cord-275433-58unu79x	13	29	sensing	sensing	NN
cord-275433-58unu79x	13	30	of	of	IN
cord-275433-58unu79x	13	31	pathogens	pathogen	NNS
cord-275433-58unu79x	13	32	,	,	,
cord-275433-58unu79x	13	33	and	and	CC
cord-275433-58unu79x	13	34	signalling	signal	VBG
cord-275433-58unu79x	13	35	pathways	pathway	NNS
cord-275433-58unu79x	13	36	that	that	WDT
cord-275433-58unu79x	13	37	induce	induce	VBP
cord-275433-58unu79x	13	38	antimicrobial	antimicrobial	JJ
cord-275433-58unu79x	13	39	states	state	NNS
cord-275433-58unu79x	13	40	in	in	IN
cord-275433-58unu79x	13	41	infected	infected	JJ
cord-275433-58unu79x	13	42	cells	cell	NNS
cord-275433-58unu79x	13	43	.	.	.
cord-275433-58unu79x	14	1	Surprisingly	surprisingly	RB
cord-275433-58unu79x	14	2	,	,	,
cord-275433-58unu79x	14	3	however	however	RB
cord-275433-58unu79x	14	4	,	,	,
cord-275433-58unu79x	14	5	microbiologists	microbiologist	NNS
cord-275433-58unu79x	14	6	and	and	CC
cord-275433-58unu79x	14	7	immunologists	immunologist	NNS
cord-275433-58unu79x	14	8	have	have	VBP
cord-275433-58unu79x	14	9	long	long	RB
cord-275433-58unu79x	14	10	overlooked	overlook	VBN
cord-275433-58unu79x	14	11	one	one	CD
cord-275433-58unu79x	14	12	of	of	IN
cord-275433-58unu79x	14	13	the	the	DT
cord-275433-58unu79x	14	14	greatest	great	JJS
cord-275433-58unu79x	14	15	challenges	challenge	NNS
cord-275433-58unu79x	14	16	that	that	WDT
cord-275433-58unu79x	14	17	the	the	DT
cord-275433-58unu79x	14	18	immune	immune	JJ
cord-275433-58unu79x	14	19	system	system	NN
cord-275433-58unu79x	14	20	faces	face	VBZ
cord-275433-58unu79x	14	21	in	in	IN
cord-275433-58unu79x	14	22	dealing	deal	VBG
cord-275433-58unu79x	14	23	with	with	IN
cord-275433-58unu79x	14	24	intracellular	intracellular	JJ
cord-275433-58unu79x	14	25	pathogens	pathogen	NNS
cord-275433-58unu79x	15	1	-that	-that	RB
cord-275433-58unu79x	15	2	is	be	VBZ
cord-275433-58unu79x	15	3	,	,	,
cord-275433-58unu79x	15	4	the	the	DT
cord-275433-58unu79x	15	5	problem	problem	NN
cord-275433-58unu79x	15	6	of	of	IN
cord-275433-58unu79x	15	7	how	how	WRB
cord-275433-58unu79x	15	8	to	to	TO
cord-275433-58unu79x	15	9	dispose	dispose	VB
cord-275433-58unu79x	15	10	of	of	IN
cord-275433-58unu79x	15	11	a	a	DT
cord-275433-58unu79x	15	12	microorganism	microorganism	NN
cord-275433-58unu79x	15	13	without	without	IN
cord-275433-58unu79x	15	14	disposing	dispose	VBG
cord-275433-58unu79x	15	15	of	of	IN
cord-275433-58unu79x	15	16	the	the	DT
cord-275433-58unu79x	15	17	entire	entire	JJ
cord-275433-58unu79x	15	18	infected	infected	JJ
cord-275433-58unu79x	15	19	cell	cell	NN
cord-275433-58unu79x	15	20	.	.	.
cord-275433-58unu79x	16	1	A	a	DT
cord-275433-58unu79x	16	2	seemingly	seemingly	RB
cord-275433-58unu79x	16	3	simple	simple	JJ
cord-275433-58unu79x	16	4	strategy	strategy	NN
cord-275433-58unu79x	16	5	to	to	TO
cord-275433-58unu79x	16	6	tackle	tackle	VB
cord-275433-58unu79x	16	7	this	this	DT
cord-275433-58unu79x	16	8	challenge	challenge	NN
cord-275433-58unu79x	16	9	is	be	VBZ
cord-275433-58unu79x	16	10	now	now	RB
cord-275433-58unu79x	16	11	beginning	begin	VBG
cord-275433-58unu79x	16	12	to	to	TO
cord-275433-58unu79x	16	13	unveil	unveil	VB
cord-275433-58unu79x	16	14	itself	-PRON-	PRP
cord-275433-58unu79x	16	15	.	.	.
cord-275433-58unu79x	17	1	Mammalian	mammalian	JJ
cord-275433-58unu79x	17	2	cells	cell	NNS
cord-275433-58unu79x	17	3	use	use	VBP
cord-275433-58unu79x	17	4	an	an	DT
cord-275433-58unu79x	17	5	evolutionarily	evolutionarily	RB
cord-275433-58unu79x	17	6	conserved	conserved	JJ
cord-275433-58unu79x	17	7	lysosomal	lysosomal	JJ
cord-275433-58unu79x	17	8	degradation	degradation	NN
cord-275433-58unu79x	17	9	pathway	pathway	NN
cord-275433-58unu79x	17	10	known	know	VBN
cord-275433-58unu79x	17	11	as	as	IN
cord-275433-58unu79x	17	12	autophagy	autophagy	NN
cord-275433-58unu79x	17	13	to	to	TO
cord-275433-58unu79x	17	14	selectively	selectively	RB
cord-275433-58unu79x	17	15	dispose	dispose	VB
cord-275433-58unu79x	17	16	of	of	IN
cord-275433-58unu79x	17	17	intracellular	intracellular	JJ
cord-275433-58unu79x	17	18	pathogens	pathogen	NNS
cord-275433-58unu79x	17	19	.	.	.
cord-275433-58unu79x	18	1	Autophagy	Autophagy	NNP
cord-275433-58unu79x	18	2	is	be	VBZ
cord-275433-58unu79x	18	3	a	a	DT
cord-275433-58unu79x	18	4	fundamental	fundamental	JJ
cord-275433-58unu79x	18	5	cellular	cellular	JJ
cord-275433-58unu79x	18	6	homeostatic	homeostatic	JJ
cord-275433-58unu79x	18	7	process	process	NN
cord-275433-58unu79x	18	8	that	that	WDT
cord-275433-58unu79x	18	9	enables	enable	VBZ
cord-275433-58unu79x	18	10	cells	cell	NNS
cord-275433-58unu79x	18	11	to	to	TO
cord-275433-58unu79x	18	12	clean	clean	VB
cord-275433-58unu79x	18	13	up	up	RP
cord-275433-58unu79x	18	14	,	,	,
cord-275433-58unu79x	18	15	in	in	IN
cord-275433-58unu79x	18	16	a	a	DT
cord-275433-58unu79x	18	17	regulated	regulated	JJ
cord-275433-58unu79x	18	18	manner	manner	NN
cord-275433-58unu79x	18	19	,	,	,
cord-275433-58unu79x	18	20	portions	portion	NNS
cord-275433-58unu79x	18	21	of	of	IN
cord-275433-58unu79x	18	22	their	-PRON-	PRP$
cord-275433-58unu79x	18	23	own	own	JJ
cord-275433-58unu79x	18	24	cytoplasm	cytoplasm	NN
cord-275433-58unu79x	18	25	and	and	CC
cord-275433-58unu79x	18	26	degrade	degrade	VB
cord-275433-58unu79x	18	27	their	-PRON-	PRP$
cord-275433-58unu79x	18	28	constituents	constituent	NNS
cord-275433-58unu79x	18	29	1	1	CD
cord-275433-58unu79x	18	30	.	.	.
cord-275433-58unu79x	19	1	This	this	DT
cord-275433-58unu79x	19	2	primordial	primordial	JJ
cord-275433-58unu79x	19	3	function	function	NN
cord-275433-58unu79x	19	4	is	be	VBZ
cord-275433-58unu79x	19	5	preserved	preserve	VBN
cord-275433-58unu79x	19	6	in	in	IN
cord-275433-58unu79x	19	7	all	all	DT
cord-275433-58unu79x	19	8	eukaryotic	eukaryotic	JJ
cord-275433-58unu79x	19	9	organisms	organism	NNS
cord-275433-58unu79x	19	10	,	,	,
cord-275433-58unu79x	19	11	from	from	IN
cord-275433-58unu79x	19	12	yeast	yeast	NN
cord-275433-58unu79x	19	13	to	to	IN
cord-275433-58unu79x	19	14	humans	human	NNS
cord-275433-58unu79x	19	15	.	.	.
cord-275433-58unu79x	20	1	During	during	IN
cord-275433-58unu79x	20	2	autophagy	autophagy	NN
cord-275433-58unu79x	20	3	,	,	,
cord-275433-58unu79x	20	4	an	an	DT
cord-275433-58unu79x	20	5	isolation	isolation	NN
cord-275433-58unu79x	20	6	membrane	membrane	NN
cord-275433-58unu79x	20	7	wraps	wrap	VBZ
cord-275433-58unu79x	20	8	around	around	IN
cord-275433-58unu79x	20	9	portions	portion	NNS
cord-275433-58unu79x	20	10	of	of	IN
cord-275433-58unu79x	20	11	the	the	DT
cord-275433-58unu79x	20	12	cytoplasm	cytoplasm	NN
cord-275433-58unu79x	20	13	to	to	TO
cord-275433-58unu79x	20	14	form	form	VB
cord-275433-58unu79x	20	15	a	a	DT
cord-275433-58unu79x	20	16	double	double	JJ
cord-275433-58unu79x	20	17	-	-	HYPH
cord-275433-58unu79x	20	18	membrane	membrane	NN
cord-275433-58unu79x	20	19	organelle	organelle	NN
cord-275433-58unu79x	20	20	known	know	VBN
cord-275433-58unu79x	20	21	as	as	IN
cord-275433-58unu79x	20	22	the	the	DT
cord-275433-58unu79x	20	23	autophagosome	autophagosome	NNP
cord-275433-58unu79x	20	24	.	.	.
cord-275433-58unu79x	21	1	The	the	DT
cord-275433-58unu79x	21	2	engulfed	engulf	VBN
cord-275433-58unu79x	21	3	cytoplasmic	cytoplasmic	JJ
cord-275433-58unu79x	21	4	material	material	NN
cord-275433-58unu79x	21	5	in	in	IN
cord-275433-58unu79x	21	6	an	an	DT
cord-275433-58unu79x	21	7	autophagosome	autophagosome	NN
cord-275433-58unu79x	21	8	is	be	VBZ
cord-275433-58unu79x	21	9	degraded	degrade	VBN
cord-275433-58unu79x	21	10	after	after	IN
cord-275433-58unu79x	21	11	fusion	fusion	NN
cord-275433-58unu79x	21	12	of	of	IN
cord-275433-58unu79x	21	13	the	the	DT
cord-275433-58unu79x	21	14	autophagosome	autophagosome	NN
cord-275433-58unu79x	21	15	with	with	IN
cord-275433-58unu79x	21	16	late	late	JJ
cord-275433-58unu79x	21	17	endosomes	endosome	NNS
cord-275433-58unu79x	21	18	or	or	CC
cord-275433-58unu79x	21	19	lysosomes	lysosome	NNS
cord-275433-58unu79x	21	20	(	(	-LRB-
cord-275433-58unu79x	21	21	FIG	fig	NN
cord-275433-58unu79x	21	22	.	.	.
cord-275433-58unu79x	21	23	1	1	CD
cord-275433-58unu79x	21	24	)	)	-RRB-
cord-275433-58unu79x	21	25	.	.	.
cord-275433-58unu79x	22	1	The	the	DT
cord-275433-58unu79x	22	2	autophagy	autophagy	NN
cord-275433-58unu79x	22	3	pathway	pathway	NN
cord-275433-58unu79x	22	4	has	have	VBZ
cord-275433-58unu79x	22	5	many	many	JJ
cord-275433-58unu79x	22	6	physiological	physiological	JJ
cord-275433-58unu79x	22	7	roles	role	NNS
cord-275433-58unu79x	22	8	,	,	,
cord-275433-58unu79x	22	9	and	and	CC
cord-275433-58unu79x	22	10	is	be	VBZ
cord-275433-58unu79x	22	11	often	often	RB
cord-275433-58unu79x	22	12	used	use	VBN
cord-275433-58unu79x	22	13	to	to	TO
cord-275433-58unu79x	22	14	remove	remove	VB
cord-275433-58unu79x	22	15	damaged	damaged	JJ
cord-275433-58unu79x	22	16	or	or	CC
cord-275433-58unu79x	22	17	surplus	surplus	JJ
cord-275433-58unu79x	22	18	organelles	organelle	NNS
cord-275433-58unu79x	22	19	.	.	.
cord-275433-58unu79x	23	1	It	-PRON-	PRP
cord-275433-58unu79x	23	2	is	be	VBZ
cord-275433-58unu79x	23	3	also	also	RB
cord-275433-58unu79x	23	4	used	use	VBN
cord-275433-58unu79x	23	5	by	by	IN
cord-275433-58unu79x	23	6	cells	cell	NNS
cord-275433-58unu79x	23	7	to	to	TO
cord-275433-58unu79x	23	8	turn	turn	VB
cord-275433-58unu79x	23	9	over	over	RP
cord-275433-58unu79x	23	10	long	long	RB
cord-275433-58unu79x	23	11	-	-	HYPH
cord-275433-58unu79x	23	12	lived	live	VBN
cord-275433-58unu79x	23	13	proteins	protein	NNS
cord-275433-58unu79x	23	14	and	and	CC
cord-275433-58unu79x	23	15	other	other	JJ
cord-275433-58unu79x	23	16	macromolecules	macromolecule	NNS
cord-275433-58unu79x	23	17	,	,	,
cord-275433-58unu79x	23	18	either	either	CC
cord-275433-58unu79x	23	19	to	to	TO
cord-275433-58unu79x	23	20	supply	supply	VB
cord-275433-58unu79x	23	21	nutrients	nutrient	NNS
cord-275433-58unu79x	23	22	for	for	IN
cord-275433-58unu79x	23	23	essential	essential	JJ
cord-275433-58unu79x	23	24	anabolic	anabolic	JJ
cord-275433-58unu79x	23	25	needs	need	NNS
cord-275433-58unu79x	23	26	under	under	IN
cord-275433-58unu79x	23	27	conditions	condition	NNS
cord-275433-58unu79x	23	28	of	of	IN
cord-275433-58unu79x	23	29	nutrient	nutrient	NN
cord-275433-58unu79x	23	30	deprivation	deprivation	NN
cord-275433-58unu79x	23	31	or	or	CC
cord-275433-58unu79x	23	32	growth	growth	NN
cord-275433-58unu79x	23	33	factor	factor	NN
cord-275433-58unu79x	23	34	withdrawal	withdrawal	NN
cord-275433-58unu79x	23	35	,	,	,
cord-275433-58unu79x	23	36	or	or	CC
cord-275433-58unu79x	23	37	to	to	TO
cord-275433-58unu79x	23	38	rid	rid	VB
cord-275433-58unu79x	23	39	cells	cell	NNS
cord-275433-58unu79x	23	40	of	of	IN
cord-275433-58unu79x	23	41	potentially	potentially	RB
cord-275433-58unu79x	23	42	toxic	toxic	JJ
cord-275433-58unu79x	23	43	aggregate	aggregate	NN
cord-275433-58unu79x	23	44	-	-	HYPH
cord-275433-58unu79x	23	45	prone	prone	JJ
cord-275433-58unu79x	23	46	proteins	protein	NNS
cord-275433-58unu79x	23	47	2	2	CD
cord-275433-58unu79x	23	48	.	.	.
cord-275433-58unu79x	24	1	The	the	DT
cord-275433-58unu79x	24	2	broad	broad	JJ
cord-275433-58unu79x	24	3	spectrum	spectrum	NN
cord-275433-58unu79x	24	4	of	of	IN
cord-275433-58unu79x	24	5	autophagy	autophagy	NN
cord-275433-58unu79x	24	6	functions	function	NNS
cord-275433-58unu79x	24	7	is	be	VBZ
cord-275433-58unu79x	24	8	intricately	intricately	RB
cord-275433-58unu79x	24	9	linked	link	VBN
cord-275433-58unu79x	24	10	to	to	IN
cord-275433-58unu79x	24	11	a	a	DT
cord-275433-58unu79x	24	12	wide	wide	JJ
cord-275433-58unu79x	24	13	range	range	NN
cord-275433-58unu79x	24	14	of	of	IN
cord-275433-58unu79x	24	15	health	health	NN
cord-275433-58unu79x	24	16	and	and	CC
cord-275433-58unu79x	24	17	disease	disease	NN
cord-275433-58unu79x	24	18	states	state	NNS
cord-275433-58unu79x	24	19	3	3	CD
cord-275433-58unu79x	24	20	,	,	,
cord-275433-58unu79x	24	21	4	4	CD
cord-275433-58unu79x	24	22	.	.	.
cord-275433-58unu79x	25	1	For	for	IN
cord-275433-58unu79x	25	2	example	example	NN
cord-275433-58unu79x	25	3	,	,	,
cord-275433-58unu79x	25	4	autophagy	autophagy	NN
cord-275433-58unu79x	25	5	is	be	VBZ
cord-275433-58unu79x	25	6	involved	involve	VBN
cord-275433-58unu79x	25	7	in	in	IN
cord-275433-58unu79x	25	8	the	the	DT
cord-275433-58unu79x	25	9	control	control	NN
cord-275433-58unu79x	25	10	of	of	IN
cord-275433-58unu79x	25	11	development	development	NN
cord-275433-58unu79x	25	12	,	,	,
cord-275433-58unu79x	25	13	tissue	tissue	NN
cord-275433-58unu79x	25	14	homeostasis	homeostasis	NN
cord-275433-58unu79x	25	15	and	and	CC
cord-275433-58unu79x	25	16	the	the	DT
cord-275433-58unu79x	25	17	lifespan	lifespan	NN
cord-275433-58unu79x	25	18	of	of	IN
cord-275433-58unu79x	25	19	an	an	DT
cord-275433-58unu79x	25	20	organism	organism	NN
cord-275433-58unu79x	25	21	;	;	:
cord-275433-58unu79x	25	22	the	the	DT
cord-275433-58unu79x	25	23	suppression	suppression	NN
cord-275433-58unu79x	25	24	of	of	IN
cord-275433-58unu79x	25	25	tumour	tumour	NN
cord-275433-58unu79x	25	26	development	development	NN
cord-275433-58unu79x	25	27	;	;	:
cord-275433-58unu79x	25	28	and	and	CC
cord-275433-58unu79x	25	29	the	the	DT
cord-275433-58unu79x	25	30	prevention	prevention	NN
cord-275433-58unu79x	25	31	of	of	IN
cord-275433-58unu79x	25	32	neurodegeneration	neurodegeneration	NN
cord-275433-58unu79x	25	33	.	.	.
cord-275433-58unu79x	26	1	Aberrant	aberrant	JJ
cord-275433-58unu79x	26	2	regulation	regulation	NN
cord-275433-58unu79x	26	3	of	of	IN
cord-275433-58unu79x	26	4	autophagy	autophagy	NN
cord-275433-58unu79x	26	5	has	have	VBZ
cord-275433-58unu79x	26	6	been	be	VBN
cord-275433-58unu79x	26	7	mechanistically	mechanistically	RB
cord-275433-58unu79x	26	8	linked	link	VBN
cord-275433-58unu79x	26	9	to	to	IN
cord-275433-58unu79x	26	10	cancer	cancer	NN
cord-275433-58unu79x	26	11	,	,	,
cord-275433-58unu79x	26	12	Huntington	Huntington	NNP
cord-275433-58unu79x	26	13	's	's	POS
cord-275433-58unu79x	26	14	disease	disease	NN
cord-275433-58unu79x	26	15	,	,	,
cord-275433-58unu79x	26	16	Parkinson	Parkinson	NNP
cord-275433-58unu79x	26	17	's	's	POS
cord-275433-58unu79x	26	18	disease	disease	NN
cord-275433-58unu79x	26	19	,	,	,
cord-275433-58unu79x	26	20	myodegeneration	myodegeneration	NN
cord-275433-58unu79x	26	21	and	and	CC
cord-275433-58unu79x	26	22	cardiomyopathy	cardiomyopathy	NN
cord-275433-58unu79x	26	23	(	(	-LRB-
cord-275433-58unu79x	26	24	BOX	box	NN
cord-275433-58unu79x	26	25	1	1	CD
cord-275433-58unu79x	26	26	)	)	-RRB-
cord-275433-58unu79x	26	27	.	.	.
cord-275433-58unu79x	27	1	Autophagy	Autophagy	NNP
cord-275433-58unu79x	27	2	also	also	RB
cord-275433-58unu79x	27	3	functions	function	VBZ
cord-275433-58unu79x	27	4	in	in	IN
cord-275433-58unu79x	27	5	diverse	diverse	JJ
cord-275433-58unu79x	27	6	aspects	aspect	NNS
cord-275433-58unu79x	27	7	of	of	IN
cord-275433-58unu79x	27	8	immunity	immunity	NN
cord-275433-58unu79x	27	9	[	[	-LRB-
cord-275433-58unu79x	27	10	5	5	CD
cord-275433-58unu79x	27	11	]	]	-RRB-
cord-275433-58unu79x	27	12	[	[	-LRB-
cord-275433-58unu79x	27	13	6	6	CD
cord-275433-58unu79x	27	14	]	]	-RRB-
cord-275433-58unu79x	27	15	[	[	-LRB-
cord-275433-58unu79x	27	16	7	7	CD
cord-275433-58unu79x	27	17	]	]	-RRB-
cord-275433-58unu79x	27	18	.	.	.
cord-275433-58unu79x	28	1	Although	although	IN
cord-275433-58unu79x	28	2	the	the	DT
cord-275433-58unu79x	28	3	term	term	NN
cord-275433-58unu79x	28	4	autophagy	autophagy	NN
cord-275433-58unu79x	28	5	means	mean	VBZ
cord-275433-58unu79x	28	6	'	'	''
cord-275433-58unu79x	28	7	to	to	TO
cord-275433-58unu79x	28	8	digest	digest	VB
cord-275433-58unu79x	28	9	oneself	oneself	PRP
cord-275433-58unu79x	28	10	'	'	''
cord-275433-58unu79x	28	11	,	,	,
cord-275433-58unu79x	28	12	it	-PRON-	PRP
cord-275433-58unu79x	28	13	is	be	VBZ
cord-275433-58unu79x	28	14	now	now	RB
cord-275433-58unu79x	28	15	clear	clear	JJ
cord-275433-58unu79x	28	16	that	that	IN
cord-275433-58unu79x	28	17	the	the	DT
cord-275433-58unu79x	28	18	autophagy	autophagy	NN
cord-275433-58unu79x	28	19	pathway	pathway	NN
cord-275433-58unu79x	28	20	also	also	RB
cord-275433-58unu79x	28	21	eliminates	eliminate	VBZ
cord-275433-58unu79x	28	22	intracellular	intracellular	JJ
cord-275433-58unu79x	28	23	pathogens	pathogen	NNS
cord-275433-58unu79x	28	24	,	,	,
cord-275433-58unu79x	28	25	including	include	VBG
cord-275433-58unu79x	28	26	viruses	virus	NNS
cord-275433-58unu79x	28	27	,	,	,
cord-275433-58unu79x	28	28	parasites	parasite	NNS
cord-275433-58unu79x	28	29	and	and	CC
cord-275433-58unu79x	28	30	bacteria	bacteria	NNS
cord-275433-58unu79x	28	31	(	(	-LRB-
cord-275433-58unu79x	28	32	a	a	DT
cord-275433-58unu79x	28	33	process	process	NN
cord-275433-58unu79x	28	34	sometimes	sometimes	RB
cord-275433-58unu79x	28	35	referred	refer	VBD
cord-275433-58unu79x	28	36	to	to	IN
cord-275433-58unu79x	28	37	as	as	IN
cord-275433-58unu79x	28	38	xenophagy	xenophagy	NNP
cord-275433-58unu79x	28	39	)	)	-RRB-
cord-275433-58unu79x	29	1	[	[	-LRB-
cord-275433-58unu79x	29	2	7	7	CD
cord-275433-58unu79x	29	3	]	]	-RRB-
cord-275433-58unu79x	29	4	[	[	-LRB-
cord-275433-58unu79x	29	5	8	8	CD
cord-275433-58unu79x	29	6	]	]	-RRB-
cord-275433-58unu79x	29	7	[	[	-LRB-
cord-275433-58unu79x	29	8	9	9	CD
cord-275433-58unu79x	29	9	]	]	-RRB-
cord-275433-58unu79x	29	10	[	[	-LRB-
cord-275433-58unu79x	29	11	10	10	CD
cord-275433-58unu79x	29	12	]	]	-RRB-
cord-275433-58unu79x	29	13	.	.	.
cord-275433-58unu79x	30	1	The	the	DT
cord-275433-58unu79x	30	2	autophagic	autophagic	NN
cord-275433-58unu79x	30	3	sequestration	sequestration	NN
cord-275433-58unu79x	30	4	of	of	IN
cord-275433-58unu79x	30	5	viral	viral	JJ
cord-275433-58unu79x	30	6	components	component	NNS
cord-275433-58unu79x	30	7	can	can	MD
cord-275433-58unu79x	30	8	also	also	RB
cord-275433-58unu79x	30	9	fuel	fuel	VB
cord-275433-58unu79x	30	10	MHC	MHC	NNP
cord-275433-58unu79x	30	11	class	class	NN
cord-275433-58unu79x	30	12	II	II	NNP
cord-275433-58unu79x	30	13	presentation	presentation	NN
cord-275433-58unu79x	30	14	of	of	IN
cord-275433-58unu79x	30	15	endogenous	endogenous	JJ
cord-275433-58unu79x	30	16	antigens	antigen	NNS
cord-275433-58unu79x	30	17	11	11	CD
cord-275433-58unu79x	30	18	and	and	CC
cord-275433-58unu79x	30	19	the	the	DT
cord-275433-58unu79x	30	20	production	production	NN
cord-275433-58unu79x	30	21	of	of	IN
cord-275433-58unu79x	30	22	type	type	NN
cord-275433-58unu79x	30	23	I	-PRON-	PRP
cord-275433-58unu79x	30	24	interferons	interferon	NNS
cord-275433-58unu79x	30	25	(	(	-LRB-
cord-275433-58unu79x	30	26	IFNs	IFNs	NNP
cord-275433-58unu79x	30	27	)	)	-RRB-
cord-275433-58unu79x	30	28	in	in	IN
cord-275433-58unu79x	30	29	response	response	NN
cord-275433-58unu79x	30	30	to	to	IN
cord-275433-58unu79x	30	31	Toll	Toll	NNP
cord-275433-58unu79x	30	32	-	-	HYPH
cord-275433-58unu79x	30	33	like	like	JJ
cord-275433-58unu79x	30	34	receptor	receptor	NN
cord-275433-58unu79x	30	35	7	7	CD
cord-275433-58unu79x	31	1	(	(	-LRB-
cord-275433-58unu79x	31	2	TLR7	TLR7	NNP
cord-275433-58unu79x	31	3	)	)	-RRB-
cord-275433-58unu79x	31	4	signalling	signal	VBG
cord-275433-58unu79x	31	5	12	12	CD
cord-275433-58unu79x	31	6	.	.	.
cord-275433-58unu79x	32	1	Furthermore	furthermore	RB
cord-275433-58unu79x	32	2	,	,	,
cord-275433-58unu79x	32	3	autophagy	autophagy	NN
cord-275433-58unu79x	32	4	may	may	MD
cord-275433-58unu79x	32	5	directly	directly	RB
cord-275433-58unu79x	32	6	affect	affect	VB
cord-275433-58unu79x	32	7	T	t	NN
cord-275433-58unu79x	32	8	-	-	HYPH
cord-275433-58unu79x	32	9	cell	cell	NN
cord-275433-58unu79x	32	10	homeostasis	homeostasis	NN
cord-275433-58unu79x	32	11	13	13	CD
cord-275433-58unu79x	32	12	,	,	,
cord-275433-58unu79x	32	13	14	14	CD
cord-275433-58unu79x	32	14	.	.	.
cord-275433-58unu79x	33	1	More	more	RBR
cord-275433-58unu79x	33	2	speculatively	speculatively	RB
cord-275433-58unu79x	33	3	,	,	,
cord-275433-58unu79x	33	4	autophagy	autophagy	NN
cord-275433-58unu79x	33	5	may	may	MD
cord-275433-58unu79x	33	6	have	have	VB
cord-275433-58unu79x	33	7	a	a	DT
cord-275433-58unu79x	33	8	role	role	NN
cord-275433-58unu79x	33	9	in	in	IN
cord-275433-58unu79x	33	10	the	the	DT
cord-275433-58unu79x	33	11	prevention	prevention	NN
cord-275433-58unu79x	33	12	of	of	IN
cord-275433-58unu79x	33	13	autoimmunity	autoimmunity	NN
cord-275433-58unu79x	33	14	and	and	CC
cord-275433-58unu79x	33	15	inflammatory	inflammatory	JJ
cord-275433-58unu79x	33	16	disorders	disorder	NNS
cord-275433-58unu79x	33	17	[	[	-LRB-
cord-275433-58unu79x	33	18	15	15	CD
cord-275433-58unu79x	33	19	]	]	-RRB-
cord-275433-58unu79x	33	20	[	[	-LRB-
cord-275433-58unu79x	33	21	16	16	CD
cord-275433-58unu79x	33	22	]	]	-RRB-
cord-275433-58unu79x	33	23	[	[	-LRB-
cord-275433-58unu79x	33	24	17	17	CD
cord-275433-58unu79x	33	25	]	]	-RRB-
cord-275433-58unu79x	33	26	[	[	-LRB-
cord-275433-58unu79x	33	27	18	18	CD
cord-275433-58unu79x	33	28	]	]	-RRB-
cord-275433-58unu79x	33	29	[	[	-LRB-
cord-275433-58unu79x	33	30	19	19	CD
cord-275433-58unu79x	33	31	]	]	-RRB-
cord-275433-58unu79x	33	32	[	[	-LRB-
cord-275433-58unu79x	33	33	20	20	CD
cord-275433-58unu79x	33	34	]	]	-RRB-
cord-275433-58unu79x	33	35	.	.	.
cord-275433-58unu79x	34	1	Here	here	RB
cord-275433-58unu79x	34	2	,	,	,
cord-275433-58unu79x	34	3	we	-PRON-	PRP
cord-275433-58unu79x	34	4	provide	provide	VBP
cord-275433-58unu79x	34	5	an	an	DT
cord-275433-58unu79x	34	6	introduction	introduction	NN
cord-275433-58unu79x	34	7	to	to	IN
cord-275433-58unu79x	34	8	the	the	DT
cord-275433-58unu79x	34	9	molecular	molecular	JJ
cord-275433-58unu79x	34	10	mechanisms	mechanism	NNS
cord-275433-58unu79x	34	11	of	of	IN
cord-275433-58unu79x	34	12	autophagy	autophagy	NN
cord-275433-58unu79x	34	13	,	,	,
cord-275433-58unu79x	34	14	discuss	discuss	VB
cord-275433-58unu79x	34	15	the	the	DT
cord-275433-58unu79x	34	16	major	major	JJ
cord-275433-58unu79x	34	17	recent	recent	JJ
cord-275433-58unu79x	34	18	advances	advance	NNS
cord-275433-58unu79x	34	19	in	in	IN
cord-275433-58unu79x	34	20	autophagy	autophagy	NN
cord-275433-58unu79x	34	21	and	and	CC
cord-275433-58unu79x	34	22	immunity	immunity	NN
cord-275433-58unu79x	34	23	,	,	,
cord-275433-58unu79x	34	24	and	and	CC
cord-275433-58unu79x	34	25	highlight	highlight	VB
cord-275433-58unu79x	34	26	important	important	JJ
cord-275433-58unu79x	34	27	unanswered	unanswered	JJ
cord-275433-58unu79x	34	28	questions	question	NNS
cord-275433-58unu79x	34	29	in	in	IN
cord-275433-58unu79x	34	30	the	the	DT
cord-275433-58unu79x	34	31	field	field	NN
cord-275433-58unu79x	34	32	.	.	.
cord-275433-58unu79x	35	1	Autophagy	autophagy	UH
cord-275433-58unu79x	35	2	:	:	:
cord-275433-58unu79x	35	3	a	a	DT
cord-275433-58unu79x	35	4	lysosomal	lysosomal	JJ
cord-275433-58unu79x	35	5	degradation	degradation	NN
cord-275433-58unu79x	35	6	pathway	pathway	NN
cord-275433-58unu79x	36	1	There	there	EX
cord-275433-58unu79x	36	2	are	be	VBP
cord-275433-58unu79x	36	3	several	several	JJ
cord-275433-58unu79x	36	4	morphologically	morphologically	RB
cord-275433-58unu79x	36	5	and	and	CC
cord-275433-58unu79x	36	6	functionally	functionally	RB
cord-275433-58unu79x	36	7	distinct	distinct	JJ
cord-275433-58unu79x	36	8	forms	form	NNS
cord-275433-58unu79x	36	9	of	of	IN
cord-275433-58unu79x	36	10	autophagy	autophagy	NN
cord-275433-58unu79x	36	11	,	,	,
cord-275433-58unu79x	36	12	including	include	VBG
cord-275433-58unu79x	36	13	macroautophagy	macroautophagy	NNS
cord-275433-58unu79x	36	14	(	(	-LRB-
cord-275433-58unu79x	36	15	herein	herein	RB
cord-275433-58unu79x	36	16	referred	refer	VBN
cord-275433-58unu79x	36	17	to	to	IN
cord-275433-58unu79x	36	18	as	as	IN
cord-275433-58unu79x	36	19	autophagy	autophagy	NN
cord-275433-58unu79x	36	20	)	)	-RRB-
cord-275433-58unu79x	36	21	,	,	,
cord-275433-58unu79x	36	22	microautophagy	microautophagy	NN
cord-275433-58unu79x	36	23	,	,	,
cord-275433-58unu79x	36	24	chaperone	chaperone	NN
cord-275433-58unu79x	36	25	-	-	HYPH
cord-275433-58unu79x	36	26	mediated	mediate	VBN
cord-275433-58unu79x	36	27	autophagy	autophagy	NN
cord-275433-58unu79x	36	28	and	and	CC
cord-275433-58unu79x	36	29	others	other	NNS
cord-275433-58unu79x	36	30	that	that	WDT
cord-275433-58unu79x	36	31	involve	involve	VBP
cord-275433-58unu79x	36	32	the	the	DT
cord-275433-58unu79x	36	33	selective	selective	JJ
cord-275433-58unu79x	36	34	degradation	degradation	NN
cord-275433-58unu79x	36	35	of	of	IN
cord-275433-58unu79x	36	36	specific	specific	JJ
cord-275433-58unu79x	36	37	organelles	organelle	NNS
cord-275433-58unu79x	36	38	(	(	-LRB-
cord-275433-58unu79x	36	39	such	such	JJ
cord-275433-58unu79x	36	40	as	as	IN
cord-275433-58unu79x	36	41	peroxisomes	peroxisome	NNS
cord-275433-58unu79x	36	42	,	,	,
cord-275433-58unu79x	36	43	mitochondria	mitochondrion	NNS
cord-275433-58unu79x	36	44	and	and	CC
cord-275433-58unu79x	36	45	the	the	DT
cord-275433-58unu79x	36	46	endoplasmic	endoplasmic	NN
cord-275433-58unu79x	36	47	reticulum	reticulum	NN
cord-275433-58unu79x	36	48	)	)	-RRB-
cord-275433-58unu79x	36	49	.	.	.
cord-275433-58unu79x	37	1	During	during	IN
cord-275433-58unu79x	37	2	the	the	DT
cord-275433-58unu79x	37	3	initiation	initiation	NN
cord-275433-58unu79x	37	4	of	of	IN
cord-275433-58unu79x	37	5	autophagy	autophagy	NN
cord-275433-58unu79x	37	6	,	,	,
cord-275433-58unu79x	37	7	a	a	DT
cord-275433-58unu79x	37	8	damaged	damage	VBN
cord-275433-58unu79x	37	9	organelle	organelle	NN
cord-275433-58unu79x	37	10	or	or	CC
cord-275433-58unu79x	37	11	a	a	DT
cord-275433-58unu79x	37	12	portion	portion	NN
cord-275433-58unu79x	37	13	of	of	IN
cord-275433-58unu79x	37	14	cytosol	cytosol	NN
cord-275433-58unu79x	37	15	is	be	VBZ
cord-275433-58unu79x	37	16	sequestered	sequester	VBN
cord-275433-58unu79x	37	17	in	in	IN
cord-275433-58unu79x	37	18	a	a	DT
cord-275433-58unu79x	37	19	structure	structure	NN
cord-275433-58unu79x	37	20	known	know	VBN
cord-275433-58unu79x	37	21	as	as	IN
cord-275433-58unu79x	37	22	the	the	DT
cord-275433-58unu79x	37	23	isolation	isolation	NN
cord-275433-58unu79x	37	24	membrane	membrane	NN
cord-275433-58unu79x	37	25	or	or	CC
cord-275433-58unu79x	37	26	phagophore	phagophore	NN
cord-275433-58unu79x	37	27	(	(	-LRB-
cord-275433-58unu79x	37	28	FIG	FIG	NNP
cord-275433-58unu79x	37	29	.	.	.
cord-275433-58unu79x	37	30	1a	1a	CD
cord-275433-58unu79x	37	31	)	)	-RRB-
cord-275433-58unu79x	37	32	.	.	.
cord-275433-58unu79x	38	1	The	the	DT
cord-275433-58unu79x	38	2	phagophore	phagophore	NN
cord-275433-58unu79x	38	3	then	then	RB
cord-275433-58unu79x	38	4	becomes	become	VBZ
cord-275433-58unu79x	38	5	enlarged	enlarge	VBN
cord-275433-58unu79x	38	6	during	during	IN
cord-275433-58unu79x	38	7	the	the	DT
cord-275433-58unu79x	38	8	elongation	elongation	NN
cord-275433-58unu79x	38	9	stages	stage	NNS
cord-275433-58unu79x	38	10	by	by	IN
cord-275433-58unu79x	38	11	the	the	DT
cord-275433-58unu79x	38	12	addition	addition	NN
cord-275433-58unu79x	38	13	of	of	IN
cord-275433-58unu79x	38	14	new	new	JJ
cord-275433-58unu79x	38	15	membrane	membrane	NN
cord-275433-58unu79x	38	16	-the	-the	ADD
cord-275433-58unu79x	38	17	origin	origin	NN
cord-275433-58unu79x	38	18	of	of	IN
cord-275433-58unu79x	38	19	which	which	WDT
cord-275433-58unu79x	38	20	is	be	VBZ
cord-275433-58unu79x	38	21	still	still	RB
cord-275433-58unu79x	38	22	unclear	unclear	JJ
cord-275433-58unu79x	38	23	.	.	.
cord-275433-58unu79x	39	1	The	the	DT
cord-275433-58unu79x	39	2	phagophore	phagophore	NN
cord-275433-58unu79x	39	3	seals	seal	VBZ
cord-275433-58unu79x	39	4	to	to	TO
cord-275433-58unu79x	39	5	form	form	VB
cord-275433-58unu79x	39	6	an	an	DT
cord-275433-58unu79x	39	7	autophagosome	autophagosome	NN
cord-275433-58unu79x	39	8	,	,	,
cord-275433-58unu79x	39	9	an	an	DT
cord-275433-58unu79x	39	10	organelle	organelle	NN
cord-275433-58unu79x	39	11	that	that	WDT
cord-275433-58unu79x	39	12	is	be	VBZ
cord-275433-58unu79x	39	13	distinguished	distinguish	VBN
cord-275433-58unu79x	39	14	from	from	IN
cord-275433-58unu79x	39	15	the	the	DT
cord-275433-58unu79x	39	16	conventional	conventional	JJ
cord-275433-58unu79x	39	17	phagosome	phagosome	NN
cord-275433-58unu79x	39	18	by	by	IN
cord-275433-58unu79x	39	19	the	the	DT
cord-275433-58unu79x	39	20	presence	presence	NN
cord-275433-58unu79x	39	21	of	of	IN
cord-275433-58unu79x	39	22	a	a	DT
cord-275433-58unu79x	39	23	double	double	JJ
cord-275433-58unu79x	39	24	delimiting	delimit	VBG
cord-275433-58unu79x	39	25	membrane	membrane	NN
cord-275433-58unu79x	39	26	(	(	-LRB-
cord-275433-58unu79x	39	27	two	two	CD
cord-275433-58unu79x	39	28	lipid	lipid	NN
cord-275433-58unu79x	39	29	bilayers	bilayer	NNS
cord-275433-58unu79x	39	30	)	)	-RRB-
cord-275433-58unu79x	39	31	and	and	CC
cord-275433-58unu79x	39	32	intra	intra	JJ
cord-275433-58unu79x	39	33	-	-	JJ
cord-275433-58unu79x	39	34	lumenal	lumenal	JJ
cord-275433-58unu79x	39	35	cytoplasmic	cytoplasmic	JJ
cord-275433-58unu79x	39	36	content	content	NN
cord-275433-58unu79x	39	37	.	.	.
cord-275433-58unu79x	40	1	During	during	IN
cord-275433-58unu79x	40	2	maturation	maturation	NN
cord-275433-58unu79x	40	3	,	,	,
cord-275433-58unu79x	40	4	autophagosomes	autophagosomes	NNP
cord-275433-58unu79x	40	5	fuse	fuse	NN
cord-275433-58unu79x	40	6	with	with	IN
cord-275433-58unu79x	40	7	lysosomes	lysosome	NNS
cord-275433-58unu79x	40	8	to	to	TO
cord-275433-58unu79x	40	9	form	form	VB
cord-275433-58unu79x	40	10	autolysosomes	autolysosome	NNS
cord-275433-58unu79x	40	11	in	in	IN
cord-275433-58unu79x	40	12	which	which	WDT
cord-275433-58unu79x	40	13	the	the	DT
cord-275433-58unu79x	40	14	captured	capture	VBN
cord-275433-58unu79x	40	15	material	material	NN
cord-275433-58unu79x	40	16	is	be	VBZ
cord-275433-58unu79x	40	17	degraded	degrade	VBN
cord-275433-58unu79x	40	18	.	.	.
cord-275433-58unu79x	41	1	The	the	DT
cord-275433-58unu79x	41	2	capture	capture	NN
cord-275433-58unu79x	41	3	of	of	IN
cord-275433-58unu79x	41	4	intracellular	intracellular	JJ
cord-275433-58unu79x	41	5	pathogens	pathogen	NNS
cord-275433-58unu79x	41	6	is	be	VBZ
cord-275433-58unu79x	41	7	thought	think	VBN
cord-275433-58unu79x	41	8	to	to	TO
cord-275433-58unu79x	41	9	follow	follow	VB
cord-275433-58unu79x	41	10	a	a	DT
cord-275433-58unu79x	41	11	similar	similar	JJ
cord-275433-58unu79x	41	12	path	path	NN
cord-275433-58unu79x	41	13	(	(	-LRB-
cord-275433-58unu79x	41	14	FIG	fig	NN
cord-275433-58unu79x	41	15	.	.	.
cord-275433-58unu79x	41	16	1b	1b	CD
cord-275433-58unu79x	41	17	)	)	-RRB-
cord-275433-58unu79x	41	18	,	,	,
cord-275433-58unu79x	41	19	although	although	IN
cord-275433-58unu79x	41	20	the	the	DT
cord-275433-58unu79x	41	21	sequestration	sequestration	NN
cord-275433-58unu79x	41	22	of	of	IN
cord-275433-58unu79x	41	23	microorganisms	microorganism	NNS
cord-275433-58unu79x	41	24	during	during	IN
cord-275433-58unu79x	41	25	autophagy	autophagy	NN
cord-275433-58unu79x	41	26	has	have	VBZ
cord-275433-58unu79x	41	27	not	not	RB
cord-275433-58unu79x	41	28	been	be	VBN
cord-275433-58unu79x	41	29	studied	study	VBN
cord-275433-58unu79x	41	30	as	as	RB
cord-275433-58unu79x	41	31	extensively	extensively	RB
cord-275433-58unu79x	41	32	as	as	IN
cord-275433-58unu79x	41	33	that	that	DT
cord-275433-58unu79x	41	34	of	of	IN
cord-275433-58unu79x	41	35	cellular	cellular	JJ
cord-275433-58unu79x	41	36	contents	content	NNS
cord-275433-58unu79x	41	37	.	.	.
cord-275433-58unu79x	42	1	Most	Most	JJS
cord-275433-58unu79x	42	2	cells	cell	NNS
cord-275433-58unu79x	42	3	undergo	undergo	VBP
cord-275433-58unu79x	42	4	some	some	DT
cord-275433-58unu79x	42	5	level	level	NN
cord-275433-58unu79x	42	6	of	of	IN
cord-275433-58unu79x	42	7	autophagy	autophagy	NN
cord-275433-58unu79x	42	8	while	while	IN
cord-275433-58unu79x	42	9	adjusting	adjust	VBG
cord-275433-58unu79x	42	10	their	-PRON-	PRP$
cord-275433-58unu79x	42	11	biomass	biomass	NN
cord-275433-58unu79x	42	12	,	,	,
cord-275433-58unu79x	42	13	removing	remove	VBG
cord-275433-58unu79x	42	14	protein	protein	NN
cord-275433-58unu79x	42	15	aggregates	aggregate	NNS
cord-275433-58unu79x	42	16	or	or	CC
cord-275433-58unu79x	42	17	eliminating	eliminate	VBG
cord-275433-58unu79x	42	18	damaged	damage	VBN
cord-275433-58unu79x	42	19	organelles	organelle	NNS
cord-275433-58unu79x	42	20	(	(	-LRB-
cord-275433-58unu79x	42	21	such	such	JJ
cord-275433-58unu79x	42	22	as	as	IN
cord-275433-58unu79x	42	23	mitochondria	mitochondrion	NNS
cord-275433-58unu79x	42	24	)	)	-RRB-
cord-275433-58unu79x	42	25	.	.	.
cord-275433-58unu79x	43	1	The	the	DT
cord-275433-58unu79x	43	2	classical	classical	JJ
cord-275433-58unu79x	43	3	signalling	signal	VBG
cord-275433-58unu79x	43	4	pathways	pathway	NNS
cord-275433-58unu79x	43	5	that	that	WDT
cord-275433-58unu79x	43	6	regulate	regulate	VBP
cord-275433-58unu79x	43	7	autophagy	autophagy	NN
cord-275433-58unu79x	43	8	have	have	VBP
cord-275433-58unu79x	43	9	been	be	VBN
cord-275433-58unu79x	43	10	reviewed	review	VBN
cord-275433-58unu79x	43	11	extensively	extensively	RB
cord-275433-58unu79x	43	12	elsewhere	elsewhere	RB
cord-275433-58unu79x	43	13	21	21	CD
cord-275433-58unu79x	43	14	,	,	,
cord-275433-58unu79x	43	15	22	22	CD
cord-275433-58unu79x	43	16	,	,	,
cord-275433-58unu79x	43	17	whereas	whereas	IN
cord-275433-58unu79x	43	18	signals	signal	NNS
cord-275433-58unu79x	43	19	of	of	IN
cord-275433-58unu79x	43	20	particular	particular	JJ
cord-275433-58unu79x	43	21	relevance	relevance	NN
cord-275433-58unu79x	43	22	to	to	IN
cord-275433-58unu79x	43	23	immunity	immunity	NN
cord-275433-58unu79x	43	24	are	be	VBP
cord-275433-58unu79x	43	25	discussed	discuss	VBN
cord-275433-58unu79x	43	26	later	later	RB
cord-275433-58unu79x	43	27	.	.	.
cord-275433-58unu79x	44	1	Key	key	JJ
cord-275433-58unu79x	44	2	players	player	NNS
cord-275433-58unu79x	44	3	in	in	IN
cord-275433-58unu79x	44	4	autophagy	autophagy	NN
cord-275433-58unu79x	44	5	regulation	regulation	NN
cord-275433-58unu79x	44	6	are	be	VBP
cord-275433-58unu79x	44	7	the	the	DT
cord-275433-58unu79x	44	8	serine	serine	NN
cord-275433-58unu79x	44	9	/	/	SYM
cord-275433-58unu79x	44	10	threonine	threonine	NN
cord-275433-58unu79x	44	11	kinase	kinase	NN
cord-275433-58unu79x	44	12	mammalian	mammalian	JJ
cord-275433-58unu79x	44	13	target	target	NN
cord-275433-58unu79x	44	14	of	of	IN
cord-275433-58unu79x	44	15	rapamycin	rapamycin	NNP
cord-275433-58unu79x	44	16	(	(	-LRB-
cord-275433-58unu79x	44	17	mTOR	mTOR	NNP
cord-275433-58unu79x	44	18	;	;	:
cord-275433-58unu79x	44	19	also	also	RB
cord-275433-58unu79x	44	20	known	know	VBN
cord-275433-58unu79x	44	21	as	as	IN
cord-275433-58unu79x	44	22	FRAP1	FRAP1	NNP
cord-275433-58unu79x	44	23	)	)	-RRB-
cord-275433-58unu79x	44	24	and	and	CC
cord-275433-58unu79x	45	1	the	the	DT
cord-275433-58unu79x	45	2	class	class	NN
cord-275433-58unu79x	45	3	I	i	NN
cord-275433-58unu79x	45	4	and	and	CC
cord-275433-58unu79x	45	5	class	class	NN
cord-275433-58unu79x	45	6	III	iii	CD
cord-275433-58unu79x	45	7	phosphoinositide	phosphoinositide	JJ
cord-275433-58unu79x	46	1	3-kinases	3-kinases	LS
cord-275433-58unu79x	46	2	(	(	-LRB-
cord-275433-58unu79x	46	3	PI3Ks	PI3Ks	NNP
cord-275433-58unu79x	46	4	)	)	-RRB-
cord-275433-58unu79x	46	5	.	.	.
cord-275433-58unu79x	47	1	Two	two	CD
cord-275433-58unu79x	47	2	well	well	RB
cord-275433-58unu79x	47	3	-	-	HYPH
cord-275433-58unu79x	47	4	characterized	characterize	VBN
cord-275433-58unu79x	47	5	stimuli	stimulus	NNS
cord-275433-58unu79x	47	6	that	that	WDT
cord-275433-58unu79x	47	7	induce	induce	VBP
cord-275433-58unu79x	47	8	autophagy	autophagy	NN
cord-275433-58unu79x	47	9	are	be	VBP
cord-275433-58unu79x	47	10	amino	amino	NN
cord-275433-58unu79x	47	11	-	-	HYPH
cord-275433-58unu79x	47	12	acid	acid	NN
cord-275433-58unu79x	47	13	starvation	starvation	NN
cord-275433-58unu79x	47	14	and	and	CC
cord-275433-58unu79x	47	15	growth	growth	NN
cord-275433-58unu79x	47	16	-	-	HYPH
cord-275433-58unu79x	47	17	factor	factor	NN
cord-275433-58unu79x	47	18	withdrawal	withdrawal	NN
cord-275433-58unu79x	47	19	2	2	CD
cord-275433-58unu79x	47	20	.	.	.
cord-275433-58unu79x	48	1	In	in	IN
cord-275433-58unu79x	48	2	response	response	NN
cord-275433-58unu79x	48	3	to	to	IN
cord-275433-58unu79x	48	4	growth	growth	NN
cord-275433-58unu79x	48	5	-	-	HYPH
cord-275433-58unu79x	48	6	factor	factor	NN
cord-275433-58unu79x	48	7	stimulation	stimulation	NN
cord-275433-58unu79x	48	8	,	,	,
cord-275433-58unu79x	48	9	class	class	NN
cord-275433-58unu79x	48	10	I	-PRON-	PRP
cord-275433-58unu79x	48	11	PI3Ks	PI3Ks	NNPS
cord-275433-58unu79x	48	12	generate	generate	VBP
cord-275433-58unu79x	48	13	phosphatidylinositol-3,4,5-trisphosphate	phosphatidylinositol-3,4,5-trisphosphate	CD
cord-275433-58unu79x	49	1	(	(	-LRB-
cord-275433-58unu79x	49	2	PtdIns(3,4,5)P	PtdIns(3,4,5)P	NNP
cord-275433-58unu79x	49	3	3	3	CD
cord-275433-58unu79x	49	4	)	)	-RRB-
cord-275433-58unu79x	49	5	on	on	IN
cord-275433-58unu79x	49	6	the	the	DT
cord-275433-58unu79x	49	7	plasma	plasma	NN
cord-275433-58unu79x	49	8	membrane	membrane	NN
cord-275433-58unu79x	49	9	by	by	IN
cord-275433-58unu79x	49	10	phosphorylating	phosphorylate	VBG
cord-275433-58unu79x	49	11	phosphatidylinositol-4,5-bisphosphate	phosphatidylinositol-4,5-bisphosphate	NN
cord-275433-58unu79x	49	12	(	(	-LRB-
cord-275433-58unu79x	49	13	PtdIns(4,5)P	PtdIns(4,5)P	NNP
cord-275433-58unu79x	49	14	2	2	CD
cord-275433-58unu79x	49	15	)	)	-RRB-
cord-275433-58unu79x	49	16	and	and	CC
cord-275433-58unu79x	49	17	in	in	IN
cord-275433-58unu79x	49	18	turn	turn	NN
cord-275433-58unu79x	49	19	PtdIns(3,4,5)P	PtdIns(3,4,5)P	NNP
cord-275433-58unu79x	49	20	3	3	NNP
cord-275433-58unu79x	49	21	activates	activate	VBZ
cord-275433-58unu79x	49	22	mTOR	mTOR	NNP
cord-275433-58unu79x	49	23	,	,	,
cord-275433-58unu79x	49	24	thereby	thereby	RB
cord-275433-58unu79x	49	25	repressing	repress	VBG
cord-275433-58unu79x	49	26	autophagy	autophagy	NN
cord-275433-58unu79x	49	27	.	.	.
cord-275433-58unu79x	50	1	The	the	DT
cord-275433-58unu79x	50	2	class	class	NN
cord-275433-58unu79x	50	3	III	iii	CD
cord-275433-58unu79x	50	4	PI3	pi3	NN
cord-275433-58unu79x	50	5	K	K	NNP
cord-275433-58unu79x	50	6	vPS34	vPS34	NNS
cord-275433-58unu79x	50	7	(	(	-LRB-
cord-275433-58unu79x	50	8	also	also	RB
cord-275433-58unu79x	50	9	known	know	VBN
cord-275433-58unu79x	50	10	as	as	IN
cord-275433-58unu79x	50	11	PIK3C3	PIK3C3	NNP
cord-275433-58unu79x	50	12	)	)	-RRB-
cord-275433-58unu79x	50	13	generates	generate	VBZ
cord-275433-58unu79x	50	14	phosphatidylinositol-3-phosphate	phosphatidylinositol-3-phosphate	NNP
cord-275433-58unu79x	50	15	(	(	-LRB-
cord-275433-58unu79x	50	16	PtdIns3P	PtdIns3P	NNS
cord-275433-58unu79x	50	17	)	)	-RRB-
cord-275433-58unu79x	50	18	by	by	IN
cord-275433-58unu79x	50	19	phosphorylating	phosphorylate	VBG
cord-275433-58unu79x	50	20	The	the	DT
cord-275433-58unu79x	50	21	cellular	cellular	JJ
cord-275433-58unu79x	50	22	events	event	NNS
cord-275433-58unu79x	50	23	during	during	IN
cord-275433-58unu79x	50	24	digestion	digestion	NN
cord-275433-58unu79x	50	25	of	of	IN
cord-275433-58unu79x	50	26	self	self	NN
cord-275433-58unu79x	50	27	constituents	constituent	NNS
cord-275433-58unu79x	50	28	or	or	CC
cord-275433-58unu79x	50	29	intracellular	intracellular	JJ
cord-275433-58unu79x	50	30	pathogens	pathogen	NNS
cord-275433-58unu79x	50	31	follow	follow	VBP
cord-275433-58unu79x	50	32	three	three	CD
cord-275433-58unu79x	50	33	distinct	distinct	JJ
cord-275433-58unu79x	50	34	stages	stage	NNS
cord-275433-58unu79x	50	35	:	:	:
cord-275433-58unu79x	50	36	initiation	initiation	NN
cord-275433-58unu79x	50	37	(	(	-LRB-
cord-275433-58unu79x	50	38	formation	formation	NN
cord-275433-58unu79x	50	39	of	of	IN
cord-275433-58unu79x	50	40	the	the	DT
cord-275433-58unu79x	50	41	phagophore	phagophore	NN
cord-275433-58unu79x	50	42	)	)	-RRB-
cord-275433-58unu79x	50	43	,	,	,
cord-275433-58unu79x	50	44	elongation	elongation	NN
cord-275433-58unu79x	50	45	(	(	-LRB-
cord-275433-58unu79x	50	46	growth	growth	NN
cord-275433-58unu79x	50	47	and	and	CC
cord-275433-58unu79x	50	48	closure	closure	NN
cord-275433-58unu79x	50	49	)	)	-RRB-
cord-275433-58unu79x	50	50	and	and	CC
cord-275433-58unu79x	50	51	maturation	maturation	NN
cord-275433-58unu79x	50	52	of	of	IN
cord-275433-58unu79x	50	53	a	a	DT
cord-275433-58unu79x	50	54	double	double	JJ
cord-275433-58unu79x	50	55	membrane	membrane	NN
cord-275433-58unu79x	50	56	autophagosome	autophagosome	NNP
cord-275433-58unu79x	50	57	into	into	IN
cord-275433-58unu79x	50	58	an	an	DT
cord-275433-58unu79x	50	59	autolysosome	autolysosome	NN
cord-275433-58unu79x	50	60	.	.	.
cord-275433-58unu79x	51	1	a	a	DT
cord-275433-58unu79x	51	2	|	|	NNP
cord-275433-58unu79x	51	3	Autophagy	Autophagy	NNP
cord-275433-58unu79x	51	4	sequesters	sequester	VBZ
cord-275433-58unu79x	51	5	and	and	CC
cord-275433-58unu79x	51	6	removes	remove	VBZ
cord-275433-58unu79x	51	7	cellular	cellular	JJ
cord-275433-58unu79x	51	8	constituents	constituent	NNS
cord-275433-58unu79x	51	9	from	from	IN
cord-275433-58unu79x	51	10	the	the	DT
cord-275433-58unu79x	51	11	cytosol	cytosol	NN
cord-275433-58unu79x	51	12	,	,	,
cord-275433-58unu79x	51	13	including	include	VBG
cord-275433-58unu79x	51	14	surplus	surplus	NN
cord-275433-58unu79x	51	15	or	or	CC
cord-275433-58unu79x	51	16	damaged	damage	VBN
cord-275433-58unu79x	51	17	organelles	organelle	NNS
cord-275433-58unu79x	51	18	from	from	IN
cord-275433-58unu79x	51	19	the	the	DT
cord-275433-58unu79x	51	20	cytosol	cytosol	NN
cord-275433-58unu79x	51	21	.	.	.
cord-275433-58unu79x	52	1	b	b	LS
cord-275433-58unu79x	52	2	|	|	NNP
cord-275433-58unu79x	52	3	Autophagy	Autophagy	NNP
cord-275433-58unu79x	52	4	can	can	MD
cord-275433-58unu79x	52	5	eliminate	eliminate	VB
cord-275433-58unu79x	52	6	bacteria	bacteria	NNS
cord-275433-58unu79x	52	7	(	(	-LRB-
cord-275433-58unu79x	52	8	free	free	JJ
cord-275433-58unu79x	52	9	in	in	IN
cord-275433-58unu79x	52	10	the	the	DT
cord-275433-58unu79x	52	11	cytosol	cytosol	NN
cord-275433-58unu79x	52	12	or	or	CC
cord-275433-58unu79x	52	13	inside	inside	IN
cord-275433-58unu79x	52	14	a	a	DT
cord-275433-58unu79x	52	15	phagosome	phagosome	NN
cord-275433-58unu79x	52	16	)	)	-RRB-
cord-275433-58unu79x	52	17	,	,	,
cord-275433-58unu79x	52	18	viruses	virus	NNS
cord-275433-58unu79x	52	19	and	and	CC
cord-275433-58unu79x	52	20	protozoan	protozoan	NN
cord-275433-58unu79x	52	21	parasites	parasite	NNS
cord-275433-58unu79x	52	22	in	in	IN
cord-275433-58unu79x	52	23	a	a	DT
cord-275433-58unu79x	52	24	manner	manner	NN
cord-275433-58unu79x	52	25	similar	similar	JJ
cord-275433-58unu79x	52	26	to	to	IN
cord-275433-58unu79x	52	27	the	the	DT
cord-275433-58unu79x	52	28	elimination	elimination	NN
cord-275433-58unu79x	52	29	of	of	IN
cord-275433-58unu79x	52	30	self	self	NN
cord-275433-58unu79x	52	31	constituents	constituent	NNS
cord-275433-58unu79x	52	32	.	.	.
cord-275433-58unu79x	53	1	The	the	DT
cord-275433-58unu79x	53	2	autophagy	autophagy	NN
cord-275433-58unu79x	53	3	pathway	pathway	NN
cord-275433-58unu79x	53	4	has	have	VBZ
cord-275433-58unu79x	53	5	numerous	numerous	JJ
cord-275433-58unu79x	53	6	adaptive	adaptive	JJ
cord-275433-58unu79x	53	7	functions	function	NNS
cord-275433-58unu79x	53	8	in	in	IN
cord-275433-58unu79x	53	9	eukaryotic	eukaryotic	JJ
cord-275433-58unu79x	53	10	organisms	organism	NNS
cord-275433-58unu79x	53	11	.	.	.
cord-275433-58unu79x	54	1	In	in	IN
cord-275433-58unu79x	54	2	cellular	cellular	JJ
cord-275433-58unu79x	54	3	starvation	starvation	NN
cord-275433-58unu79x	54	4	settings	setting	NNS
cord-275433-58unu79x	54	5	,	,	,
cord-275433-58unu79x	54	6	autophagy	autophagy	NN
cord-275433-58unu79x	54	7	functions	function	NNS
cord-275433-58unu79x	54	8	to	to	TO
cord-275433-58unu79x	54	9	preserve	preserve	VB
cord-275433-58unu79x	54	10	cellular	cellular	JJ
cord-275433-58unu79x	54	11	bioenergetics	bioenergetic	NNS
cord-275433-58unu79x	54	12	by	by	IN
cord-275433-58unu79x	54	13	providing	provide	VBG
cord-275433-58unu79x	54	14	metabolic	metabolic	JJ
cord-275433-58unu79x	54	15	substrates	substrate	NNS
cord-275433-58unu79x	54	16	(	(	-LRB-
cord-275433-58unu79x	54	17	obtained	obtain	VBN
cord-275433-58unu79x	54	18	through	through	IN
cord-275433-58unu79x	54	19	bulk	bulk	JJ
cord-275433-58unu79x	54	20	cytoplasmic	cytoplasmic	JJ
cord-275433-58unu79x	54	21	degradation	degradation	NN
cord-275433-58unu79x	54	22	)	)	-RRB-
cord-275433-58unu79x	54	23	,	,	,
cord-275433-58unu79x	54	24	which	which	WDT
cord-275433-58unu79x	54	25	maintains	maintain	VBZ
cord-275433-58unu79x	54	26	macromolecular	macromolecular	JJ
cord-275433-58unu79x	54	27	synthesis	synthesis	NN
cord-275433-58unu79x	54	28	and	and	CC
cord-275433-58unu79x	54	29	ATP	ATP	NNP
cord-275433-58unu79x	54	30	production	production	NN
cord-275433-58unu79x	54	31	.	.	.
cord-275433-58unu79x	55	1	Another	another	DT
cord-275433-58unu79x	55	2	important	important	JJ
cord-275433-58unu79x	55	3	function	function	NN
cord-275433-58unu79x	55	4	of	of	IN
cord-275433-58unu79x	55	5	autophagy	autophagy	NN
cord-275433-58unu79x	55	6	that	that	WDT
cord-275433-58unu79x	55	7	probably	probably	RB
cord-275433-58unu79x	55	8	underlies	underlie	VBZ
cord-275433-58unu79x	55	9	its	-PRON-	PRP$
cord-275433-58unu79x	55	10	protective	protective	JJ
cord-275433-58unu79x	55	11	role	role	NN
cord-275433-58unu79x	55	12	against	against	IN
cord-275433-58unu79x	55	13	diverse	diverse	JJ
cord-275433-58unu79x	55	14	pathologies	pathology	NNS
cord-275433-58unu79x	55	15	is	be	VBZ
cord-275433-58unu79x	55	16	its	-PRON-	PRP$
cord-275433-58unu79x	55	17	ability	ability	NN
cord-275433-58unu79x	55	18	to	to	TO
cord-275433-58unu79x	55	19	perform	perform	VB
cord-275433-58unu79x	55	20	'	'	``
cord-275433-58unu79x	55	21	routine	routine	JJ
cord-275433-58unu79x	55	22	housecleaning	housecleaning	NN
cord-275433-58unu79x	55	23	'	'	''
cord-275433-58unu79x	55	24	and	and	CC
cord-275433-58unu79x	55	25	also	also	RB
cord-275433-58unu79x	55	26	to	to	TO
cord-275433-58unu79x	55	27	clean	clean	VB
cord-275433-58unu79x	55	28	-	-	HYPH
cord-275433-58unu79x	55	29	up	up	RP
cord-275433-58unu79x	55	30	toxic	toxic	JJ
cord-275433-58unu79x	55	31	or	or	CC
cord-275433-58unu79x	55	32	damaged	damage	VBN
cord-275433-58unu79x	55	33	cytoplasmic	cytoplasmic	JJ
cord-275433-58unu79x	55	34	constituents	constituent	NNS
cord-275433-58unu79x	55	35	,	,	,
cord-275433-58unu79x	55	36	a	a	DT
cord-275433-58unu79x	55	37	process	process	NN
cord-275433-58unu79x	55	38	that	that	WDT
cord-275433-58unu79x	55	39	may	may	MD
cord-275433-58unu79x	55	40	have	have	VB
cord-275433-58unu79x	55	41	more	more	JJR
cord-275433-58unu79x	55	42	selectivity	selectivity	NN
cord-275433-58unu79x	55	43	than	than	IN
cord-275433-58unu79x	55	44	autophagy	autophagy	NN
cord-275433-58unu79x	55	45	induced	induce	VBN
cord-275433-58unu79x	55	46	by	by	IN
cord-275433-58unu79x	55	47	cell	cell	NN
cord-275433-58unu79x	55	48	starvation	starvation	NN
cord-275433-58unu79x	55	49	.	.	.
cord-275433-58unu79x	56	1	This	this	DT
cord-275433-58unu79x	56	2	function	function	NN
cord-275433-58unu79x	56	3	of	of	IN
cord-275433-58unu79x	56	4	autophagy	autophagy	NN
cord-275433-58unu79x	56	5	contributes	contribute	VBZ
cord-275433-58unu79x	56	6	to	to	IN
cord-275433-58unu79x	56	7	its	-PRON-	PRP$
cord-275433-58unu79x	56	8	protection	protection	NN
cord-275433-58unu79x	56	9	against	against	IN
cord-275433-58unu79x	56	10	neurodegenerative	neurodegenerative	JJ
cord-275433-58unu79x	56	11	disease	disease	NN
cord-275433-58unu79x	56	12	;	;	:
cord-275433-58unu79x	56	13	it	-PRON-	PRP
cord-275433-58unu79x	56	14	has	have	VBZ
cord-275433-58unu79x	56	15	a	a	DT
cord-275433-58unu79x	56	16	basal	basal	JJ
cord-275433-58unu79x	56	17	role	role	NN
cord-275433-58unu79x	56	18	in	in	IN
cord-275433-58unu79x	56	19	preventing	prevent	VBG
cord-275433-58unu79x	56	20	the	the	DT
cord-275433-58unu79x	56	21	abnormal	abnormal	JJ
cord-275433-58unu79x	56	22	accumulation	accumulation	NN
cord-275433-58unu79x	56	23	of	of	IN
cord-275433-58unu79x	56	24	ubiquitylated	ubiquitylated	JJ
cord-275433-58unu79x	56	25	protein	protein	NN
cord-275433-58unu79x	56	26	aggregates	aggregate	NNS
cord-275433-58unu79x	56	27	and	and	CC
cord-275433-58unu79x	56	28	it	-PRON-	PRP
cord-275433-58unu79x	56	29	specifically	specifically	RB
cord-275433-58unu79x	56	30	degrades	degrade	VBZ
cord-275433-58unu79x	56	31	toxic	toxic	JJ
cord-275433-58unu79x	56	32	aggregate	aggregate	NN
cord-275433-58unu79x	56	33	-	-	HYPH
cord-275433-58unu79x	56	34	prone	prone	JJ
cord-275433-58unu79x	56	35	mutant	mutant	JJ
cord-275433-58unu79x	56	36	polyglutamine	polyglutamine	JJ
cord-275433-58unu79x	56	37	expansion	expansion	NN
cord-275433-58unu79x	56	38	proteins	protein	NNS
cord-275433-58unu79x	56	39	.	.	.
cord-275433-58unu79x	57	1	The	the	DT
cord-275433-58unu79x	57	2	degradation	degradation	NN
cord-275433-58unu79x	57	3	of	of	IN
cord-275433-58unu79x	57	4	damaged	damaged	JJ
cord-275433-58unu79x	57	5	mitochondria	mitochondrion	NNS
cord-275433-58unu79x	57	6	and	and	CC
cord-275433-58unu79x	57	7	other	other	JJ
cord-275433-58unu79x	57	8	organelles	organelle	NNS
cord-275433-58unu79x	57	9	also	also	RB
cord-275433-58unu79x	57	10	may	may	MD
cord-275433-58unu79x	57	11	underlie	underlie	VB
cord-275433-58unu79x	57	12	the	the	DT
cord-275433-58unu79x	57	13	antiageing	antiagee	VBG
cord-275433-58unu79x	57	14	effects	effect	NNS
cord-275433-58unu79x	57	15	and	and	CC
cord-275433-58unu79x	57	16	the	the	DT
cord-275433-58unu79x	57	17	tumour	tumour	NN
cord-275433-58unu79x	57	18	suppressor	suppressor	NN
cord-275433-58unu79x	57	19	effects	effect	NNS
cord-275433-58unu79x	57	20	of	of	IN
cord-275433-58unu79x	57	21	autophagy	autophagy	NN
cord-275433-58unu79x	57	22	,	,	,
cord-275433-58unu79x	57	23	by	by	IN
cord-275433-58unu79x	57	24	helping	help	VBG
cord-275433-58unu79x	57	25	to	to	TO
cord-275433-58unu79x	57	26	reduce	reduce	VB
cord-275433-58unu79x	57	27	genotoxic	genotoxic	JJ
cord-275433-58unu79x	57	28	stress	stress	NN
cord-275433-58unu79x	57	29	and	and	CC
cord-275433-58unu79x	57	30	to	to	TO
cord-275433-58unu79x	57	31	prevent	prevent	VB
cord-275433-58unu79x	57	32	DNA	dna	NN
cord-275433-58unu79x	57	33	damage	damage	NN
cord-275433-58unu79x	57	34	and	and	CC
cord-275433-58unu79x	57	35	genomic	genomic	JJ
cord-275433-58unu79x	57	36	instability	instability	NN
cord-275433-58unu79x	57	37	.	.	.
cord-275433-58unu79x	58	1	In	in	IN
cord-275433-58unu79x	58	2	parallel	parallel	NN
cord-275433-58unu79x	58	3	to	to	IN
cord-275433-58unu79x	58	4	cleaning	cleaning	NN
cord-275433-58unu79x	58	5	-	-	HYPH
cord-275433-58unu79x	58	6	up	up	RP
cord-275433-58unu79x	58	7	endogenous	endogenous	JJ
cord-275433-58unu79x	58	8	cellular	cellular	JJ
cord-275433-58unu79x	58	9	constituents	constituent	NNS
cord-275433-58unu79x	58	10	,	,	,
cord-275433-58unu79x	58	11	autophagy	autophagy	NN
cord-275433-58unu79x	58	12	cleans	clean	VBZ
cord-275433-58unu79x	58	13	up	up	RP
cord-275433-58unu79x	58	14	intracellular	intracellular	JJ
cord-275433-58unu79x	58	15	microorganisms	microorganism	NNS
cord-275433-58unu79x	58	16	,	,	,
cord-275433-58unu79x	58	17	thereby	thereby	RB
cord-275433-58unu79x	58	18	protecting	protect	VBG
cord-275433-58unu79x	58	19	against	against	IN
cord-275433-58unu79x	58	20	disease	disease	NN
cord-275433-58unu79x	58	21	caused	cause	VBN
cord-275433-58unu79x	58	22	by	by	IN
cord-275433-58unu79x	58	23	intracellular	intracellular	JJ
cord-275433-58unu79x	58	24	pathogens	pathogen	NNS
cord-275433-58unu79x	58	25	.	.	.
cord-275433-58unu79x	59	1	Autophagy	Autophagy	NNP
cord-275433-58unu79x	59	2	also	also	RB
cord-275433-58unu79x	59	3	can	can	MD
cord-275433-58unu79x	59	4	selectively	selectively	RB
cord-275433-58unu79x	59	5	deliver	deliver	VB
cord-275433-58unu79x	59	6	microbial	microbial	JJ
cord-275433-58unu79x	59	7	genetic	genetic	JJ
cord-275433-58unu79x	59	8	material	material	NN
cord-275433-58unu79x	59	9	and	and	CC
cord-275433-58unu79x	59	10	antigens	antigen	NNS
cord-275433-58unu79x	59	11	to	to	IN
cord-275433-58unu79x	59	12	the	the	DT
cord-275433-58unu79x	59	13	innate	innate	JJ
cord-275433-58unu79x	59	14	and	and	CC
cord-275433-58unu79x	59	15	adaptive	adaptive	JJ
cord-275433-58unu79x	59	16	immune	immune	JJ
cord-275433-58unu79x	59	17	systems	system	NNS
cord-275433-58unu79x	59	18	.	.	.
cord-275433-58unu79x	60	1	Some	some	DT
cord-275433-58unu79x	60	2	of	of	IN
cord-275433-58unu79x	60	3	these	these	DT
cord-275433-58unu79x	60	4	effects	effect	NNS
cord-275433-58unu79x	60	5	on	on	IN
cord-275433-58unu79x	60	6	immune	immune	JJ
cord-275433-58unu79x	60	7	regulation	regulation	NN
cord-275433-58unu79x	60	8	and	and	CC
cord-275433-58unu79x	60	9	bacterial	bacterial	JJ
cord-275433-58unu79x	60	10	clearance	clearance	NN
cord-275433-58unu79x	60	11	may	may	MD
cord-275433-58unu79x	60	12	explain	explain	VB
cord-275433-58unu79x	60	13	the	the	DT
cord-275433-58unu79x	60	14	recently	recently	RB
cord-275433-58unu79x	60	15	uncovered	uncover	VBN
cord-275433-58unu79x	60	16	genetic	genetic	JJ
cord-275433-58unu79x	60	17	linkage	linkage	NN
cord-275433-58unu79x	60	18	between	between	IN
cord-275433-58unu79x	60	19	autophagy	autophagy	NN
cord-275433-58unu79x	60	20	genes	gene	NNS
cord-275433-58unu79x	60	21	and	and	CC
cord-275433-58unu79x	60	22	susceptibility	susceptibility	NN
cord-275433-58unu79x	60	23	to	to	IN
cord-275433-58unu79x	60	24	Crohn	Crohn	NNP
cord-275433-58unu79x	60	25	's	's	POS
cord-275433-58unu79x	60	26	disease	disease	NN
cord-275433-58unu79x	60	27	.	.	.
cord-275433-58unu79x	61	1	Given	give	VBN
cord-275433-58unu79x	61	2	the	the	DT
cord-275433-58unu79x	61	3	diverse	diverse	JJ
cord-275433-58unu79x	61	4	functions	function	NNS
cord-275433-58unu79x	61	5	of	of	IN
cord-275433-58unu79x	61	6	autophagy	autophagy	NN
cord-275433-58unu79x	61	7	in	in	IN
cord-275433-58unu79x	61	8	health	health	NN
cord-275433-58unu79x	61	9	and	and	CC
cord-275433-58unu79x	61	10	disease	disease	NN
cord-275433-58unu79x	61	11	,	,	,
cord-275433-58unu79x	61	12	there	there	EX
cord-275433-58unu79x	61	13	is	be	VBZ
cord-275433-58unu79x	61	14	now	now	RB
cord-275433-58unu79x	61	15	considerable	considerable	JJ
cord-275433-58unu79x	61	16	interest	interest	NN
cord-275433-58unu79x	61	17	in	in	IN
cord-275433-58unu79x	61	18	targeting	target	VBG
cord-275433-58unu79x	61	19	the	the	DT
cord-275433-58unu79x	61	20	autophagy	autophagy	NN
cord-275433-58unu79x	61	21	pathway	pathway	NN
cord-275433-58unu79x	61	22	in	in	IN
cord-275433-58unu79x	61	23	the	the	DT
cord-275433-58unu79x	61	24	treatment	treatment	NN
cord-275433-58unu79x	61	25	of	of	IN
cord-275433-58unu79x	61	26	different	different	JJ
cord-275433-58unu79x	61	27	diseases	disease	NNS
cord-275433-58unu79x	61	28	,	,	,
cord-275433-58unu79x	61	29	including	include	VBG
cord-275433-58unu79x	61	30	cancer	cancer	NN
cord-275433-58unu79x	61	31	,	,	,
cord-275433-58unu79x	61	32	neurodegenerative	neurodegenerative	JJ
cord-275433-58unu79x	61	33	diseases	disease	NNS
cord-275433-58unu79x	61	34	,	,	,
cord-275433-58unu79x	61	35	heart	heart	NN
cord-275433-58unu79x	61	36	diseases	disease	NNS
cord-275433-58unu79x	61	37	,	,	,
cord-275433-58unu79x	61	38	ageing	age	VBG
cord-275433-58unu79x	61	39	,	,	,
cord-275433-58unu79x	61	40	infectious	infectious	JJ
cord-275433-58unu79x	61	41	diseases	disease	NNS
cord-275433-58unu79x	61	42	and	and	CC
cord-275433-58unu79x	61	43	Crohn	Crohn	NNP
cord-275433-58unu79x	61	44	's	's	POS
cord-275433-58unu79x	61	45	disease	disease	NN
cord-275433-58unu79x	61	46	.	.	.
cord-275433-58unu79x	62	1	However	however	RB
cord-275433-58unu79x	62	2	,	,	,
cord-275433-58unu79x	62	3	for	for	IN
cord-275433-58unu79x	62	4	some	some	DT
cord-275433-58unu79x	62	5	of	of	IN
cord-275433-58unu79x	62	6	these	these	DT
cord-275433-58unu79x	62	7	diseases	disease	NNS
cord-275433-58unu79x	62	8	,	,	,
cord-275433-58unu79x	62	9	such	such	JJ
cord-275433-58unu79x	62	10	as	as	IN
cord-275433-58unu79x	62	11	cancer	cancer	NN
cord-275433-58unu79x	62	12	and	and	CC
cord-275433-58unu79x	62	13	heart	heart	NN
cord-275433-58unu79x	62	14	disease	disease	NN
cord-275433-58unu79x	62	15	,	,	,
cord-275433-58unu79x	62	16	there	there	EX
cord-275433-58unu79x	62	17	is	be	VBZ
cord-275433-58unu79x	62	18	intense	intense	JJ
cord-275433-58unu79x	62	19	debate	debate	NN
cord-275433-58unu79x	62	20	as	as	IN
cord-275433-58unu79x	62	21	to	to	IN
cord-275433-58unu79x	62	22	whether	whether	IN
cord-275433-58unu79x	62	23	autophagy	autophagy	NN
cord-275433-58unu79x	62	24	should	should	MD
cord-275433-58unu79x	62	25	be	be	VB
cord-275433-58unu79x	62	26	turned	turn	VBN
cord-275433-58unu79x	62	27	on	on	RP
cord-275433-58unu79x	62	28	or	or	CC
cord-275433-58unu79x	62	29	turned	turn	VBN
cord-275433-58unu79x	62	30	off	off	RP
cord-275433-58unu79x	62	31	,	,	,
cord-275433-58unu79x	62	32	with	with	IN
cord-275433-58unu79x	62	33	no	no	DT
cord-275433-58unu79x	62	34	clear	clear	RB
cord-275433-58unu79x	62	35	-	-	HYPH
cord-275433-58unu79x	62	36	cut	cut	VBN
cord-275433-58unu79x	62	37	data	datum	NNS
cord-275433-58unu79x	62	38	to	to	TO
cord-275433-58unu79x	62	39	resolve	resolve	VB
cord-275433-58unu79x	62	40	the	the	DT
cord-275433-58unu79x	62	41	debate	debate	NN
cord-275433-58unu79x	62	42	.	.	.
cord-275433-58unu79x	63	1	For	for	IN
cord-275433-58unu79x	63	2	other	other	JJ
cord-275433-58unu79x	63	3	conditions	condition	NNS
cord-275433-58unu79x	63	4	,	,	,
cord-275433-58unu79x	63	5	such	such	JJ
cord-275433-58unu79x	63	6	as	as	IN
cord-275433-58unu79x	63	7	ageing	ageing	JJ
cord-275433-58unu79x	63	8	and	and	CC
cord-275433-58unu79x	63	9	neurodegenerative	neurodegenerative	JJ
cord-275433-58unu79x	63	10	diseases	disease	NNS
cord-275433-58unu79x	63	11	,	,	,
cord-275433-58unu79x	63	12	presently	presently	RB
cord-275433-58unu79x	63	13	available	available	JJ
cord-275433-58unu79x	63	14	data	datum	NNS
cord-275433-58unu79x	63	15	suggest	suggest	VBP
cord-275433-58unu79x	63	16	that	that	IN
cord-275433-58unu79x	63	17	autophagy	autophagy	NN
cord-275433-58unu79x	63	18	augmentation	augmentation	NN
cord-275433-58unu79x	63	19	is	be	VBZ
cord-275433-58unu79x	63	20	likely	likely	JJ
cord-275433-58unu79x	63	21	to	to	TO
cord-275433-58unu79x	63	22	be	be	VB
cord-275433-58unu79x	63	23	beneficial	beneficial	JJ
cord-275433-58unu79x	63	24	.	.	.
cord-275433-58unu79x	64	1	In	in	IN
cord-275433-58unu79x	64	2	the	the	DT
cord-275433-58unu79x	64	3	case	case	NN
cord-275433-58unu79x	64	4	of	of	IN
cord-275433-58unu79x	64	5	infectious	infectious	JJ
cord-275433-58unu79x	64	6	diseases	disease	NNS
cord-275433-58unu79x	64	7	,	,	,
cord-275433-58unu79x	64	8	it	-PRON-	PRP
cord-275433-58unu79x	64	9	is	be	VBZ
cord-275433-58unu79x	64	10	also	also	RB
cord-275433-58unu79x	64	11	likely	likely	JJ
cord-275433-58unu79x	64	12	that	that	IN
cord-275433-58unu79x	64	13	,	,	,
cord-275433-58unu79x	64	14	at	at	IN
cord-275433-58unu79x	64	15	least	least	JJS
cord-275433-58unu79x	64	16	in	in	IN
cord-275433-58unu79x	64	17	most	most	JJS
cord-275433-58unu79x	64	18	cases	case	NNS
cord-275433-58unu79x	64	19	,	,	,
cord-275433-58unu79x	64	20	autophagy	autophagy	NN
cord-275433-58unu79x	64	21	induction	induction	NN
cord-275433-58unu79x	64	22	will	will	MD
cord-275433-58unu79x	64	23	foster	foster	VB
cord-275433-58unu79x	64	24	increased	increase	VBN
cord-275433-58unu79x	64	25	innate	innate	JJ
cord-275433-58unu79x	64	26	and	and	CC
cord-275433-58unu79x	64	27	adaptive	adaptive	JJ
cord-275433-58unu79x	64	28	immunity	immunity	NN
cord-275433-58unu79x	64	29	.	.	.
cord-275433-58unu79x	65	1	Nonetheless	nonetheless	RB
cord-275433-58unu79x	65	2	,	,	,
cord-275433-58unu79x	65	3	the	the	DT
cord-275433-58unu79x	65	4	possibility	possibility	NN
cord-275433-58unu79x	65	5	that	that	IN
cord-275433-58unu79x	65	6	certain	certain	JJ
cord-275433-58unu79x	65	7	microorganisms	microorganism	NNS
cord-275433-58unu79x	65	8	may	may	MD
cord-275433-58unu79x	65	9	fare	fare	VB
cord-275433-58unu79x	65	10	better	well	RBR
cord-275433-58unu79x	65	11	in	in	IN
cord-275433-58unu79x	65	12	the	the	DT
cord-275433-58unu79x	65	13	setting	setting	NN
cord-275433-58unu79x	65	14	of	of	IN
cord-275433-58unu79x	65	15	increased	increase	VBN
cord-275433-58unu79x	65	16	autophagy	autophagy	NN
cord-275433-58unu79x	65	17	remains	remain	VBZ
cord-275433-58unu79x	65	18	.	.	.
cord-275433-58unu79x	66	1	Macroautophagy	Macroautophagy	NNP
cord-275433-58unu79x	66	2	(	(	-LRB-
cord-275433-58unu79x	66	3	Also	also	RB
cord-275433-58unu79x	66	4	known	know	VBN
cord-275433-58unu79x	66	5	as	as	IN
cord-275433-58unu79x	66	6	autophagy	autophagy	NN
cord-275433-58unu79x	66	7	)	)	-RRB-
cord-275433-58unu79x	66	8	.	.	.
cord-275433-58unu79x	67	1	The	the	DT
cord-275433-58unu79x	67	2	largely	largely	RB
cord-275433-58unu79x	67	3	non	non	JJ
cord-275433-58unu79x	67	4	-	-	JJ
cord-275433-58unu79x	67	5	specific	specific	JJ
cord-275433-58unu79x	67	6	autophagic	autophagic	NN
cord-275433-58unu79x	67	7	sequestration	sequestration	NN
cord-275433-58unu79x	67	8	of	of	IN
cord-275433-58unu79x	67	9	cytoplasm	cytoplasm	NN
cord-275433-58unu79x	67	10	into	into	IN
cord-275433-58unu79x	67	11	a	a	DT
cord-275433-58unu79x	67	12	doubleor	doubleor	JJ
cord-275433-58unu79x	67	13	multiple	multiple	JJ
cord-275433-58unu79x	67	14	-	-	HYPH
cord-275433-58unu79x	67	15	membranedelimited	membranedelimited	JJ
cord-275433-58unu79x	67	16	compartment	compartment	NN
cord-275433-58unu79x	67	17	(	(	-LRB-
cord-275433-58unu79x	67	18	an	an	DT
cord-275433-58unu79x	67	19	autophagosome	autophagosome	NN
cord-275433-58unu79x	67	20	)	)	-RRB-
cord-275433-58unu79x	67	21	of	of	IN
cord-275433-58unu79x	67	22	nonlysosomal	nonlysosomal	NNP
cord-275433-58unu79x	67	23	origin	origin	NNP
cord-275433-58unu79x	67	24	.	.	.
cord-275433-58unu79x	68	1	Note	note	VB
cord-275433-58unu79x	68	2	that	that	IN
cord-275433-58unu79x	68	3	certain	certain	JJ
cord-275433-58unu79x	68	4	proteins	protein	NNS
cord-275433-58unu79x	68	5	,	,	,
cord-275433-58unu79x	68	6	organelles	organelle	NNS
cord-275433-58unu79x	68	7	and	and	CC
cord-275433-58unu79x	68	8	pathogens	pathogen	NNS
cord-275433-58unu79x	68	9	may	may	MD
cord-275433-58unu79x	68	10	be	be	VB
cord-275433-58unu79x	68	11	selectively	selectively	RB
cord-275433-58unu79x	68	12	degraded	degrade	VBN
cord-275433-58unu79x	68	13	via	via	IN
cord-275433-58unu79x	68	14	macroautophagy	macroautophagy	NNS
cord-275433-58unu79x	68	15	.	.	.
cord-275433-58unu79x	69	1	The	the	DT
cord-275433-58unu79x	69	2	uptake	uptake	NN
cord-275433-58unu79x	69	3	and	and	CC
cord-275433-58unu79x	69	4	degradation	degradation	NN
cord-275433-58unu79x	69	5	of	of	IN
cord-275433-58unu79x	69	6	cytoplasm	cytoplasm	NN
cord-275433-58unu79x	69	7	by	by	IN
cord-275433-58unu79x	69	8	invagination	invagination	NN
cord-275433-58unu79x	69	9	of	of	IN
cord-275433-58unu79x	69	10	the	the	DT
cord-275433-58unu79x	69	11	lysosomal	lysosomal	JJ
cord-275433-58unu79x	69	12	membrane	membrane	NN
cord-275433-58unu79x	69	13	.	.	.
cord-275433-58unu79x	70	1	The	the	DT
cord-275433-58unu79x	70	2	import	import	NN
cord-275433-58unu79x	70	3	and	and	CC
cord-275433-58unu79x	70	4	degradation	degradation	NN
cord-275433-58unu79x	70	5	of	of	IN
cord-275433-58unu79x	70	6	soluble	soluble	JJ
cord-275433-58unu79x	70	7	cytosolic	cytosolic	JJ
cord-275433-58unu79x	70	8	proteins	protein	NNS
cord-275433-58unu79x	70	9	by	by	IN
cord-275433-58unu79x	70	10	chaperone	chaperone	NN
cord-275433-58unu79x	70	11	-	-	HYPH
cord-275433-58unu79x	70	12	dependent	dependent	JJ
cord-275433-58unu79x	70	13	,	,	,
cord-275433-58unu79x	70	14	direct	direct	JJ
cord-275433-58unu79x	70	15	translocation	translocation	NN
cord-275433-58unu79x	70	16	across	across	IN
cord-275433-58unu79x	70	17	the	the	DT
cord-275433-58unu79x	70	18	lysosomal	lysosomal	JJ
cord-275433-58unu79x	70	19	membrane	membrane	NN
cord-275433-58unu79x	70	20	.	.	.
cord-275433-58unu79x	71	1	(	(	-LRB-
cord-275433-58unu79x	71	2	siRNA	siRNA	NNP
cord-275433-58unu79x	71	3	)	)	-RRB-
cord-275433-58unu79x	71	4	.	.	.
cord-275433-58unu79x	72	1	Synthetic	Synthetic	NNP
cord-275433-58unu79x	72	2	RNA	RNA	NNP
cord-275433-58unu79x	72	3	molecules	molecule	NNS
cord-275433-58unu79x	72	4	of	of	IN
cord-275433-58unu79x	72	5	19	19	CD
cord-275433-58unu79x	72	6	-	-	SYM
cord-275433-58unu79x	72	7	23	23	CD
cord-275433-58unu79x	72	8	nucleotides	nucleotide	NNS
cord-275433-58unu79x	72	9	that	that	WDT
cord-275433-58unu79x	72	10	are	be	VBP
cord-275433-58unu79x	72	11	used	use	VBN
cord-275433-58unu79x	72	12	to	to	TO
cord-275433-58unu79x	72	13	'	'	``
cord-275433-58unu79x	72	14	knockdown	knockdown	NN
cord-275433-58unu79x	72	15	'	'	''
cord-275433-58unu79x	72	16	(	(	-LRB-
cord-275433-58unu79x	72	17	that	that	RB
cord-275433-58unu79x	72	18	is	is	RB
cord-275433-58unu79x	72	19	,	,	,
cord-275433-58unu79x	72	20	silence	silence	VB
cord-275433-58unu79x	72	21	the	the	DT
cord-275433-58unu79x	72	22	expression	expression	NN
cord-275433-58unu79x	72	23	of	of	IN
cord-275433-58unu79x	72	24	)	)	-RRB-
cord-275433-58unu79x	72	25	a	a	DT
cord-275433-58unu79x	72	26	specific	specific	JJ
cord-275433-58unu79x	72	27	gene	gene	NN
cord-275433-58unu79x	72	28	.	.	.
cord-275433-58unu79x	73	1	This	this	DT
cord-275433-58unu79x	73	2	is	be	VBZ
cord-275433-58unu79x	73	3	known	know	VBN
cord-275433-58unu79x	73	4	as	as	IN
cord-275433-58unu79x	73	5	RNA	RNA	NNP
cord-275433-58unu79x	73	6	interference	interference	NN
cord-275433-58unu79x	73	7	(	(	-LRB-
cord-275433-58unu79x	73	8	RNAi	RNAi	NNP
cord-275433-58unu79x	73	9	)	)	-RRB-
cord-275433-58unu79x	73	10	and	and	CC
cord-275433-58unu79x	73	11	is	be	VBZ
cord-275433-58unu79x	73	12	mediated	mediate	VBN
cord-275433-58unu79x	73	13	by	by	IN
cord-275433-58unu79x	73	14	the	the	DT
cord-275433-58unu79x	73	15	sequencespecific	sequencespecific	JJ
cord-275433-58unu79x	73	16	degradation	degradation	NN
cord-275433-58unu79x	73	17	of	of	IN
cord-275433-58unu79x	73	18	mRNA	mRNA	NNP
cord-275433-58unu79x	73	19	.	.	.
cord-275433-58unu79x	74	1	PtdIns	PtdIns	NNP
cord-275433-58unu79x	74	2	on	on	IN
cord-275433-58unu79x	74	3	endomembranes	endomembrane	NNS
cord-275433-58unu79x	74	4	and	and	CC
cord-275433-58unu79x	74	5	acts	act	VBZ
cord-275433-58unu79x	74	6	at	at	IN
cord-275433-58unu79x	74	7	several	several	JJ
cord-275433-58unu79x	74	8	steps	step	NNS
cord-275433-58unu79x	74	9	along	along	IN
cord-275433-58unu79x	74	10	the	the	DT
cord-275433-58unu79x	74	11	signalling	signal	VBG
cord-275433-58unu79x	74	12	pathway	pathway	NN
cord-275433-58unu79x	74	13	associated	associate	VBN
cord-275433-58unu79x	74	14	with	with	IN
cord-275433-58unu79x	74	15	autophagy	autophagy	NN
cord-275433-58unu79x	74	16	(	(	-LRB-
cord-275433-58unu79x	74	17	FIG	fig	NN
cord-275433-58unu79x	74	18	.	.	.
cord-275433-58unu79x	74	19	2	2	CD
cord-275433-58unu79x	74	20	)	)	-RRB-
cord-275433-58unu79x	74	21	.	.	.
cord-275433-58unu79x	75	1	when	when	WRB
cord-275433-58unu79x	75	2	amino	amino	JJ
cord-275433-58unu79x	75	3	acids	acid	NNS
cord-275433-58unu79x	75	4	are	be	VBP
cord-275433-58unu79x	75	5	plentiful	plentiful	JJ
cord-275433-58unu79x	75	6	,	,	,
cord-275433-58unu79x	75	7	vPS34	vPS34	NNP
cord-275433-58unu79x	75	8	contributes	contribute	VBZ
cord-275433-58unu79x	75	9	to	to	IN
cord-275433-58unu79x	75	10	mTOR	mTOR	NNP
cord-275433-58unu79x	75	11	activation	activation	NN
cord-275433-58unu79x	75	12	,	,	,
cord-275433-58unu79x	75	13	thereby	thereby	RB
cord-275433-58unu79x	75	14	repressing	repress	VBG
cord-275433-58unu79x	75	15	autophagy	autophagy	NN
cord-275433-58unu79x	75	16	23	23	CD
cord-275433-58unu79x	75	17	,	,	,
cord-275433-58unu79x	75	18	24	24	CD
cord-275433-58unu79x	75	19	.	.	.
cord-275433-58unu79x	76	1	by	by	IN
cord-275433-58unu79x	76	2	contrast	contrast	NN
cord-275433-58unu79x	76	3	,	,	,
cord-275433-58unu79x	76	4	the	the	DT
cord-275433-58unu79x	76	5	initiation	initiation	NN
cord-275433-58unu79x	76	6	stages	stage	NNS
cord-275433-58unu79x	76	7	of	of	IN
cord-275433-58unu79x	76	8	autophagy	autophagy	NN
cord-275433-58unu79x	76	9	depend	depend	VBP
cord-275433-58unu79x	76	10	on	on	IN
cord-275433-58unu79x	76	11	vPS34	vPS34	NNS
cord-275433-58unu79x	76	12	in	in	IN
cord-275433-58unu79x	76	13	a	a	DT
cord-275433-58unu79x	76	14	complex	complex	NN
cord-275433-58unu79x	76	15	with	with	IN
cord-275433-58unu79x	76	16	the	the	DT
cord-275433-58unu79x	76	17	autophagy	autophagy	NN
cord-275433-58unu79x	76	18	-	-	HYPH
cord-275433-58unu79x	76	19	associated	associate	VBN
cord-275433-58unu79x	76	20	protein	protein	NN
cord-275433-58unu79x	76	21	beclin	beclin	NNP
cord-275433-58unu79x	76	22	1	1	CD
cord-275433-58unu79x	76	23	(	(	-LRB-
cord-275433-58unu79x	76	24	also	also	RB
cord-275433-58unu79x	76	25	known	know	VBN
cord-275433-58unu79x	76	26	as	as	IN
cord-275433-58unu79x	76	27	ATG6	ATG6	NNP
cord-275433-58unu79x	76	28	)	)	-RRB-
cord-275433-58unu79x	76	29	25	25	CD
cord-275433-58unu79x	76	30	.	.	.
cord-275433-58unu79x	77	1	The	the	DT
cord-275433-58unu79x	77	2	beclin-1-vPS34	beclin-1-vPS34	NNP
cord-275433-58unu79x	77	3	autophagy	autophagy	NN
cord-275433-58unu79x	77	4	complex	complex	NN
cord-275433-58unu79x	77	5	can	can	MD
cord-275433-58unu79x	77	6	be	be	VB
cord-275433-58unu79x	77	7	activated	activate	VBN
cord-275433-58unu79x	77	8	by	by	IN
cord-275433-58unu79x	77	9	the	the	DT
cord-275433-58unu79x	77	10	beclin-1-interacting	beclin-1-interacte	VBG
cord-275433-58unu79x	77	11	partners	partner	NNS
cord-275433-58unu79x	77	12	,	,	,
cord-275433-58unu79x	77	13	uvRAG	uvrag	IN
cord-275433-58unu79x	78	1	(	(	-LRB-
cord-275433-58unu79x	78	2	uv	uv	NN
cord-275433-58unu79x	78	3	radiation	radiation	NN
cord-275433-58unu79x	78	4	resistance	resistance	NN
cord-275433-58unu79x	78	5	associated	associate	VBN
cord-275433-58unu79x	78	6	gene	gene	NN
cord-275433-58unu79x	78	7	)	)	-RRB-
cord-275433-58unu79x	78	8	26	26	CD
cord-275433-58unu79x	78	9	and	and	CC
cord-275433-58unu79x	78	10	AMbRA1	AMbRA1	NNP
cord-275433-58unu79x	78	11	(	(	-LRB-
cord-275433-58unu79x	78	12	activating	activate	VBG
cord-275433-58unu79x	78	13	molecule	molecule	NN
cord-275433-58unu79x	78	14	in	in	IN
cord-275433-58unu79x	78	15	beclin-1-regulated	beclin-1-regulated	NNP
cord-275433-58unu79x	78	16	autophagy	autophagy	NN
cord-275433-58unu79x	78	17	)	)	-RRB-
cord-275433-58unu79x	78	18	27	27	CD
cord-275433-58unu79x	78	19	,	,	,
cord-275433-58unu79x	78	20	and	and	CC
cord-275433-58unu79x	78	21	inhibited	inhibit	VBN
cord-275433-58unu79x	78	22	by	by	IN
cord-275433-58unu79x	78	23	another	another	DT
cord-275433-58unu79x	78	24	beclin-1-interacting	beclin-1-interacte	VBG
cord-275433-58unu79x	78	25	partner	partner	NN
cord-275433-58unu79x	78	26	,	,	,
cord-275433-58unu79x	78	27	bCL-2	bCL-2	NNP
cord-275433-58unu79x	78	28	(	(	-LRB-
cord-275433-58unu79x	78	29	b	b	NN
cord-275433-58unu79x	78	30	-	-	HYPH
cord-275433-58unu79x	78	31	cell	cell	NN
cord-275433-58unu79x	78	32	lymphoma	lymphoma	NN
cord-275433-58unu79x	78	33	2	2	CD
cord-275433-58unu79x	78	34	)	)	-RRB-
cord-275433-58unu79x	78	35	28	28	CD
cord-275433-58unu79x	78	36	.	.	.
cord-275433-58unu79x	79	1	Pharmacological	pharmacological	JJ
cord-275433-58unu79x	79	2	induction	induction	NN
cord-275433-58unu79x	79	3	of	of	IN
cord-275433-58unu79x	79	4	autophagy	autophagy	NN
cord-275433-58unu79x	79	5	can	can	MD
cord-275433-58unu79x	79	6	be	be	VB
cord-275433-58unu79x	79	7	achieved	achieve	VBN
cord-275433-58unu79x	79	8	using	use	VBG
cord-275433-58unu79x	79	9	rapamycin	rapamycin	NN
cord-275433-58unu79x	79	10	,	,	,
cord-275433-58unu79x	79	11	a	a	DT
cord-275433-58unu79x	79	12	drug	drug	NN
cord-275433-58unu79x	79	13	that	that	WDT
cord-275433-58unu79x	79	14	inhibits	inhibit	VBZ
cord-275433-58unu79x	79	15	mTOR	mTOR	NNP
cord-275433-58unu79x	79	16	activity	activity	NN
cord-275433-58unu79x	79	17	29	29	CD
cord-275433-58unu79x	79	18	,	,	,
cord-275433-58unu79x	79	19	whereas	whereas	IN
cord-275433-58unu79x	79	20	pharmacological	pharmacological	JJ
cord-275433-58unu79x	79	21	inhibition	inhibition	NN
cord-275433-58unu79x	79	22	of	of	IN
cord-275433-58unu79x	79	23	autophagy	autophagy	NN
cord-275433-58unu79x	79	24	can	can	MD
cord-275433-58unu79x	79	25	be	be	VB
cord-275433-58unu79x	79	26	achieved	achieve	VBN
cord-275433-58unu79x	79	27	using	use	VBG
cord-275433-58unu79x	79	28	3-methyladenine	3-methyladenine	CD
cord-275433-58unu79x	79	29	,	,	,
cord-275433-58unu79x	79	30	a	a	DT
cord-275433-58unu79x	79	31	drug	drug	NN
cord-275433-58unu79x	79	32	that	that	WDT
cord-275433-58unu79x	79	33	inhibits	inhibit	VBZ
cord-275433-58unu79x	79	34	class	class	NN
cord-275433-58unu79x	79	35	III	iii	CD
cord-275433-58unu79x	79	36	PI3	pi3	NN
cord-275433-58unu79x	79	37	K	K	NNP
cord-275433-58unu79x	79	38	activity	activity	NN
cord-275433-58unu79x	79	39	30	30	CD
cord-275433-58unu79x	79	40	.	.	.
cord-275433-58unu79x	80	1	It	-PRON-	PRP
cord-275433-58unu79x	80	2	is	be	VBZ
cord-275433-58unu79x	80	3	noteworthy	noteworthy	JJ
cord-275433-58unu79x	80	4	,	,	,
cord-275433-58unu79x	80	5	however	however	RB
cord-275433-58unu79x	80	6	,	,	,
cord-275433-58unu79x	80	7	that	that	IN
cord-275433-58unu79x	80	8	as	as	IN
cord-275433-58unu79x	80	9	mTOR	mTOR	NNP
cord-275433-58unu79x	80	10	and	and	CC
cord-275433-58unu79x	80	11	class	class	NN
cord-275433-58unu79x	80	12	III	iii	CD
cord-275433-58unu79x	80	13	PI3Ks	PI3Ks	NNPS
cord-275433-58unu79x	80	14	have	have	VBP
cord-275433-58unu79x	80	15	pleiotropic	pleiotropic	JJ
cord-275433-58unu79x	80	16	cellular	cellular	JJ
cord-275433-58unu79x	80	17	functions	function	NNS
cord-275433-58unu79x	80	18	,	,	,
cord-275433-58unu79x	80	19	both	both	DT
cord-275433-58unu79x	80	20	of	of	IN
cord-275433-58unu79x	80	21	these	these	DT
cord-275433-58unu79x	80	22	drugs	drug	NNS
cord-275433-58unu79x	80	23	are	be	VBP
cord-275433-58unu79x	80	24	potent	potent	JJ
cord-275433-58unu79x	80	25	,	,	,
cord-275433-58unu79x	80	26	but	but	CC
cord-275433-58unu79x	80	27	not	not	RB
cord-275433-58unu79x	80	28	specific	specific	JJ
cord-275433-58unu79x	80	29	,	,	,
cord-275433-58unu79x	80	30	regulators	regulator	NNS
cord-275433-58unu79x	80	31	of	of	IN
cord-275433-58unu79x	80	32	autophagy	autophagy	NN
cord-275433-58unu79x	80	33	.	.	.
cord-275433-58unu79x	81	1	Knockdown	knockdown	NN
cord-275433-58unu79x	81	2	of	of	IN
cord-275433-58unu79x	81	3	expression	expression	NN
cord-275433-58unu79x	81	4	of	of	IN
cord-275433-58unu79x	81	5	autophagy	autophagy	NN
cord-275433-58unu79x	81	6	-	-	HYPH
cord-275433-58unu79x	81	7	related	relate	VBN
cord-275433-58unu79x	81	8	genes	gene	NNS
cord-275433-58unu79x	81	9	by	by	IN
cord-275433-58unu79x	81	10	small	small	JJ
cord-275433-58unu79x	81	11	interfering	interfere	VBG
cord-275433-58unu79x	81	12	RNA	RNA	NNP
cord-275433-58unu79x	81	13	(	(	-LRB-
cord-275433-58unu79x	81	14	siRNA	siRNA	NNP
cord-275433-58unu79x	81	15	)	)	-RRB-
cord-275433-58unu79x	81	16	is	be	VBZ
cord-275433-58unu79x	81	17	therefore	therefore	RB
cord-275433-58unu79x	81	18	an	an	DT
cord-275433-58unu79x	81	19	indispensable	indispensable	JJ
cord-275433-58unu79x	81	20	tool	tool	NN
cord-275433-58unu79x	81	21	for	for	IN
cord-275433-58unu79x	81	22	selectively	selectively	RB
cord-275433-58unu79x	81	23	probing	probe	VBG
cord-275433-58unu79x	81	24	the	the	DT
cord-275433-58unu79x	81	25	role	role	NN
cord-275433-58unu79x	81	26	of	of	IN
cord-275433-58unu79x	81	27	autophagy	autophagy	NN
cord-275433-58unu79x	81	28	in	in	IN
cord-275433-58unu79x	81	29	defined	define	VBN
cord-275433-58unu79x	81	30	biological	biological	JJ
cord-275433-58unu79x	81	31	processes	process	NNS
cord-275433-58unu79x	81	32	.	.	.
cord-275433-58unu79x	82	1	The	the	DT
cord-275433-58unu79x	82	2	execution	execution	NN
cord-275433-58unu79x	82	3	of	of	IN
cord-275433-58unu79x	82	4	autophagy	autophagy	NN
cord-275433-58unu79x	82	5	is	be	VBZ
cord-275433-58unu79x	82	6	mediated	mediate	VBN
cord-275433-58unu79x	82	7	by	by	IN
cord-275433-58unu79x	82	8	evolutionarily	evolutionarily	RB
cord-275433-58unu79x	82	9	conserved	conserve	VBN
cord-275433-58unu79x	82	10	proteins	protein	NNS
cord-275433-58unu79x	82	11	known	know	VBN
cord-275433-58unu79x	82	12	as	as	IN
cord-275433-58unu79x	82	13	the	the	DT
cord-275433-58unu79x	82	14	autophagy	autophagy	NN
cord-275433-58unu79x	82	15	-	-	HYPH
cord-275433-58unu79x	82	16	related	relate	VBN
cord-275433-58unu79x	82	17	(	(	-LRB-
cord-275433-58unu79x	82	18	ATG	ATG	NNP
cord-275433-58unu79x	82	19	)	)	-RRB-
cord-275433-58unu79x	82	20	proteins	protein	VBZ
cord-275433-58unu79x	82	21	31	31	CD
cord-275433-58unu79x	82	22	.	.	.
cord-275433-58unu79x	83	1	The	the	DT
cord-275433-58unu79x	83	2	molecular	molecular	JJ
cord-275433-58unu79x	83	3	mechanisms	mechanism	NNS
cord-275433-58unu79x	83	4	by	by	IN
cord-275433-58unu79x	83	5	which	which	WDT
cord-275433-58unu79x	83	6	this	this	DT
cord-275433-58unu79x	83	7	group	group	NN
cord-275433-58unu79x	83	8	of	of	IN
cord-275433-58unu79x	83	9	proteins	protein	NNS
cord-275433-58unu79x	83	10	mediates	mediate	VBZ
cord-275433-58unu79x	83	11	autophagy	autophagy	NN
cord-275433-58unu79x	83	12	has	have	VBZ
cord-275433-58unu79x	83	13	been	be	VBN
cord-275433-58unu79x	83	14	the	the	DT
cord-275433-58unu79x	83	15	subject	subject	NN
cord-275433-58unu79x	83	16	of	of	IN
cord-275433-58unu79x	83	17	recent	recent	JJ
cord-275433-58unu79x	83	18	reviews	review	NNS
cord-275433-58unu79x	83	19	3,32	3,32	NNP
cord-275433-58unu79x	83	20	-	-	HYPH
cord-275433-58unu79x	83	21	34	34	CD
cord-275433-58unu79x	83	22	and	and	CC
cord-275433-58unu79x	83	23	is	be	VBZ
cord-275433-58unu79x	83	24	depicted	depict	VBN
cord-275433-58unu79x	83	25	schematically	schematically	RB
cord-275433-58unu79x	83	26	in	in	IN
cord-275433-58unu79x	83	27	FIG	FIG	NNP
cord-275433-58unu79x	83	28	.	.	.
cord-275433-58unu79x	84	1	2	2	LS
cord-275433-58unu79x	84	2	.	.	.
cord-275433-58unu79x	85	1	Autophagosomal	Autophagosomal	NNP
cord-275433-58unu79x	85	2	membrane	membrane	NN
cord-275433-58unu79x	85	3	formation	formation	NN
cord-275433-58unu79x	85	4	and	and	CC
cord-275433-58unu79x	85	5	expansion	expansion	NN
cord-275433-58unu79x	85	6	is	be	VBZ
cord-275433-58unu79x	85	7	facilitated	facilitate	VBN
cord-275433-58unu79x	85	8	by	by	IN
cord-275433-58unu79x	85	9	two	two	CD
cord-275433-58unu79x	85	10	specialized	specialized	JJ
cord-275433-58unu79x	85	11	protein	protein	NN
cord-275433-58unu79x	85	12	conjugation	conjugation	NN
cord-275433-58unu79x	85	13	systems	system	NNS
cord-275433-58unu79x	85	14	(	(	-LRB-
cord-275433-58unu79x	85	15	FIG	fig	NN
cord-275433-58unu79x	85	16	.	.	.
cord-275433-58unu79x	85	17	2	2	CD
cord-275433-58unu79x	85	18	)	)	-RRB-
cord-275433-58unu79x	85	19	,	,	,
cord-275433-58unu79x	85	20	the	the	DT
cord-275433-58unu79x	85	21	ATG8	ATG8	NNP
cord-275433-58unu79x	85	22	(	(	-LRB-
cord-275433-58unu79x	85	23	known	know	VBN
cord-275433-58unu79x	85	24	as	as	IN
cord-275433-58unu79x	85	25	LC3	lc3	NN
cord-275433-58unu79x	85	26	in	in	IN
cord-275433-58unu79x	85	27	mammals	mammal	NNS
cord-275433-58unu79x	85	28	)	)	-RRB-
cord-275433-58unu79x	85	29	system	system	NN
cord-275433-58unu79x	85	30	and	and	CC
cord-275433-58unu79x	85	31	the	the	DT
cord-275433-58unu79x	85	32	ATG12	ATG12	NNP
cord-275433-58unu79x	85	33	system	system	NN
cord-275433-58unu79x	85	34	.	.	.
cord-275433-58unu79x	86	1	This	this	DT
cord-275433-58unu79x	86	2	results	result	VBZ
cord-275433-58unu79x	86	3	in	in	IN
cord-275433-58unu79x	86	4	the	the	DT
cord-275433-58unu79x	86	5	carboxy	carboxy	JJ
cord-275433-58unu79x	86	6	-	-	HYPH
cord-275433-58unu79x	86	7	terminal	terminal	NN
cord-275433-58unu79x	86	8	conjugation	conjugation	NN
cord-275433-58unu79x	86	9	of	of	IN
cord-275433-58unu79x	86	10	LC3	LC3	NNP
cord-275433-58unu79x	86	11	to	to	IN
cord-275433-58unu79x	86	12	the	the	DT
cord-275433-58unu79x	86	13	lipid	lipid	NN
cord-275433-58unu79x	86	14	phosphatidylethanolamine	phosphatidylethanolamine	NN
cord-275433-58unu79x	86	15	(	(	-LRB-
cord-275433-58unu79x	86	16	Pe	Pe	NNP
cord-275433-58unu79x	86	17	)	)	-RRB-
cord-275433-58unu79x	86	18	and	and	CC
cord-275433-58unu79x	86	19	the	the	DT
cord-275433-58unu79x	86	20	localization	localization	NN
cord-275433-58unu79x	86	21	of	of	IN
cord-275433-58unu79x	86	22	lipidated	lipidate	VBN
cord-275433-58unu79x	86	23	LC3	LC3	NNP
cord-275433-58unu79x	86	24	(	(	-LRB-
cord-275433-58unu79x	86	25	LC3-II	lc3-ii	NN
cord-275433-58unu79x	86	26	;	;	:
cord-275433-58unu79x	86	27	also	also	RB
cord-275433-58unu79x	86	28	known	know	VBN
cord-275433-58unu79x	86	29	as	as	IN
cord-275433-58unu79x	86	30	ATG8-Pe	ATG8-Pe	NNP
cord-275433-58unu79x	86	31	)	)	-RRB-
cord-275433-58unu79x	86	32	to	to	TO
cord-275433-58unu79x	86	33	autophagic	autophagic	JJ
cord-275433-58unu79x	86	34	membranes	membrane	NNS
cord-275433-58unu79x	86	35	.	.	.
cord-275433-58unu79x	87	1	Membrane	membrane	NN
cord-275433-58unu79x	87	2	-	-	HYPH
cord-275433-58unu79x	87	3	associated	associate	VBN
cord-275433-58unu79x	87	4	LC3-II	lc3-ii	NN
cord-275433-58unu79x	87	5	has	have	VBZ
cord-275433-58unu79x	87	6	become	become	VBN
cord-275433-58unu79x	87	7	the	the	DT
cord-275433-58unu79x	87	8	most	most	RBS
cord-275433-58unu79x	87	9	universally	universally	RB
cord-275433-58unu79x	87	10	used	use	VBN
cord-275433-58unu79x	87	11	marker	marker	NN
cord-275433-58unu79x	87	12	for	for	IN
cord-275433-58unu79x	87	13	the	the	DT
cord-275433-58unu79x	87	14	detection	detection	NN
cord-275433-58unu79x	87	15	of	of	IN
cord-275433-58unu79x	87	16	membranes	membrane	NNS
cord-275433-58unu79x	87	17	that	that	WDT
cord-275433-58unu79x	87	18	are	be	VBP
cord-275433-58unu79x	87	19	undergoing	undergo	VBG
cord-275433-58unu79x	87	20	autophagy	autophagy	NN
cord-275433-58unu79x	87	21	.	.	.
cord-275433-58unu79x	88	1	Interestingly	interestingly	RB
cord-275433-58unu79x	88	2	,	,	,
cord-275433-58unu79x	88	3	LC3	LC3	NNP
cord-275433-58unu79x	88	4	interacts	interact	VBZ
cord-275433-58unu79x	88	5	with	with	IN
cord-275433-58unu79x	88	6	p62	p62	NN
cord-275433-58unu79x	88	7	(	(	-LRB-
cord-275433-58unu79x	88	8	sequestosome-1	sequestosome-1	NNP
cord-275433-58unu79x	88	9	;	;	:
cord-275433-58unu79x	88	10	also	also	RB
cord-275433-58unu79x	88	11	known	know	VBN
cord-275433-58unu79x	88	12	as	as	IN
cord-275433-58unu79x	88	13	SQSTM1	SQSTM1	NNP
cord-275433-58unu79x	88	14	)	)	-RRB-
cord-275433-58unu79x	88	15	,	,	,
cord-275433-58unu79x	88	16	a	a	DT
cord-275433-58unu79x	88	17	protein	protein	NN
cord-275433-58unu79x	88	18	that	that	WDT
cord-275433-58unu79x	88	19	recognizes	recognize	VBZ
cord-275433-58unu79x	88	20	polyubiquitylated	polyubiquitylated	JJ
cord-275433-58unu79x	88	21	protein	protein	NN
cord-275433-58unu79x	88	22	aggregates	aggregate	NNS
cord-275433-58unu79x	88	23	(	(	-LRB-
cord-275433-58unu79x	88	24	that	that	WDT
cord-275433-58unu79x	88	25	are	be	VBP
cord-275433-58unu79x	88	26	too	too	RB
cord-275433-58unu79x	88	27	big	big	JJ
cord-275433-58unu79x	88	28	Autophagy	Autophagy	NNP
cord-275433-58unu79x	88	29	is	be	VBZ
cord-275433-58unu79x	88	30	regulated	regulate	VBN
cord-275433-58unu79x	88	31	by	by	IN
cord-275433-58unu79x	88	32	a	a	DT
cord-275433-58unu79x	88	33	set	set	NN
cord-275433-58unu79x	88	34	of	of	IN
cord-275433-58unu79x	88	35	autophagy	autophagy	NN
cord-275433-58unu79x	88	36	-	-	HYPH
cord-275433-58unu79x	88	37	related	relate	VBN
cord-275433-58unu79x	88	38	proteins	protein	NNS
cord-275433-58unu79x	88	39	(	(	-LRB-
cord-275433-58unu79x	88	40	ATG	ATG	NNP
cord-275433-58unu79x	88	41	proteins	protein	NNS
cord-275433-58unu79x	88	42	)	)	-RRB-
cord-275433-58unu79x	88	43	.	.	.
cord-275433-58unu79x	89	1	In	in	IN
cord-275433-58unu79x	89	2	the	the	DT
cord-275433-58unu79x	89	3	absence	absence	NN
cord-275433-58unu79x	89	4	of	of	IN
cord-275433-58unu79x	89	5	amino	amino	JJ
cord-275433-58unu79x	89	6	acids	acid	NNS
cord-275433-58unu79x	89	7	or	or	CC
cord-275433-58unu79x	89	8	in	in	IN
cord-275433-58unu79x	89	9	response	response	NN
cord-275433-58unu79x	89	10	to	to	IN
cord-275433-58unu79x	89	11	other	other	JJ
cord-275433-58unu79x	89	12	stimuli	stimulus	NNS
cord-275433-58unu79x	89	13	,	,	,
cord-275433-58unu79x	89	14	ATG1	ATG1	NNP
cord-275433-58unu79x	89	15	and	and	CC
cord-275433-58unu79x	89	16	a	a	DT
cord-275433-58unu79x	89	17	complex	complex	NN
cord-275433-58unu79x	89	18	of	of	IN
cord-275433-58unu79x	89	19	the	the	DT
cord-275433-58unu79x	89	20	class	class	NN
cord-275433-58unu79x	89	21	III	iii	CD
cord-275433-58unu79x	89	22	PI3	pi3	NN
cord-275433-58unu79x	89	23	K	K	NNP
cord-275433-58unu79x	89	24	(	(	-LRB-
cord-275433-58unu79x	89	25	phosphoinositide	phosphoinositide	NNP
cord-275433-58unu79x	89	26	3-kinase	3-kinase	CD
cord-275433-58unu79x	89	27	)	)	-RRB-
cord-275433-58unu79x	89	28	VPS34	VPS34	NNP
cord-275433-58unu79x	89	29	and	and	CC
cord-275433-58unu79x	89	30	beclin	beclin	NNP
cord-275433-58unu79x	89	31	1	1	CD
cord-275433-58unu79x	89	32	lead	lead	NN
cord-275433-58unu79x	89	33	to	to	IN
cord-275433-58unu79x	89	34	the	the	DT
cord-275433-58unu79x	89	35	activation	activation	NN
cord-275433-58unu79x	89	36	of	of	IN
cord-275433-58unu79x	89	37	downstream	downstream	JJ
cord-275433-58unu79x	89	38	ATG	ATG	NNP
cord-275433-58unu79x	89	39	factors	factor	NNS
cord-275433-58unu79x	89	40	that	that	WDT
cord-275433-58unu79x	89	41	are	be	VBP
cord-275433-58unu79x	89	42	involved	involve	VBN
cord-275433-58unu79x	89	43	in	in	IN
cord-275433-58unu79x	89	44	the	the	DT
cord-275433-58unu79x	89	45	initiation	initiation	NN
cord-275433-58unu79x	89	46	(	(	-LRB-
cord-275433-58unu79x	89	47	a	a	LS
cord-275433-58unu79x	89	48	)	)	-RRB-
cord-275433-58unu79x	89	49	,	,	,
cord-275433-58unu79x	89	50	elongation	elongation	NN
cord-275433-58unu79x	89	51	(	(	-LRB-
cord-275433-58unu79x	89	52	b	b	NN
cord-275433-58unu79x	89	53	)	)	-RRB-
cord-275433-58unu79x	89	54	and	and	CC
cord-275433-58unu79x	89	55	maturation	maturation	NN
cord-275433-58unu79x	89	56	(	(	-LRB-
cord-275433-58unu79x	89	57	c	c	NN
cord-275433-58unu79x	89	58	)	)	-RRB-
cord-275433-58unu79x	89	59	of	of	IN
cord-275433-58unu79x	89	60	autophagy	autophagy	NN
cord-275433-58unu79x	89	61	.	.	.
cord-275433-58unu79x	90	1	a	a	DT
cord-275433-58unu79x	90	2	|	|	CD
cord-275433-58unu79x	91	1	In	in	IN
cord-275433-58unu79x	91	2	amino	amino	NN
cord-275433-58unu79x	91	3	-	-	HYPH
cord-275433-58unu79x	91	4	acid	acid	NN
cord-275433-58unu79x	91	5	-	-	HYPH
cord-275433-58unu79x	91	6	rich	rich	JJ
cord-275433-58unu79x	91	7	conditions	condition	NNS
cord-275433-58unu79x	91	8	,	,	,
cord-275433-58unu79x	91	9	VPS34	VPS34	NNP
cord-275433-58unu79x	91	10	contributes	contribute	VBZ
cord-275433-58unu79x	91	11	to	to	IN
cord-275433-58unu79x	91	12	mTOR	mTOR	NNP
cord-275433-58unu79x	91	13	(	(	-LRB-
cord-275433-58unu79x	91	14	mammalian	mammalian	JJ
cord-275433-58unu79x	91	15	target	target	NN
cord-275433-58unu79x	91	16	of	of	IN
cord-275433-58unu79x	91	17	rapamycin	rapamycin	NN
cord-275433-58unu79x	91	18	)	)	-RRB-
cord-275433-58unu79x	91	19	activation	activation	NN
cord-275433-58unu79x	91	20	and	and	CC
cord-275433-58unu79x	91	21	inhibition	inhibition	NN
cord-275433-58unu79x	91	22	of	of	IN
cord-275433-58unu79x	91	23	ATG1	ATG1	NNP
cord-275433-58unu79x	91	24	and	and	CC
cord-275433-58unu79x	91	25	autophagy	autophagy	NN
cord-275433-58unu79x	91	26	.	.	.
cord-275433-58unu79x	92	1	The	the	DT
cord-275433-58unu79x	92	2	sources	source	NNS
cord-275433-58unu79x	92	3	of	of	IN
cord-275433-58unu79x	92	4	membrane	membrane	NN
cord-275433-58unu79x	92	5	for	for	IN
cord-275433-58unu79x	92	6	autophagosome	autophagosome	JJ
cord-275433-58unu79x	92	7	initiation	initiation	NN
cord-275433-58unu79x	92	8	and	and	CC
cord-275433-58unu79x	92	9	elongation	elongation	NN
cord-275433-58unu79x	92	10	may	may	MD
cord-275433-58unu79x	92	11	include	include	VB
cord-275433-58unu79x	92	12	those	those	DT
cord-275433-58unu79x	92	13	containing	contain	VBG
cord-275433-58unu79x	92	14	the	the	DT
cord-275433-58unu79x	92	15	only	only	RB
cord-275433-58unu79x	92	16	known	know	VBN
cord-275433-58unu79x	92	17	membrane	membrane	NN
cord-275433-58unu79x	92	18	integral	integral	JJ
cord-275433-58unu79x	92	19	ATG	ATG	NNP
cord-275433-58unu79x	92	20	protein	protein	NN
cord-275433-58unu79x	92	21	ATG9	ATG9	NNP
cord-275433-58unu79x	92	22	,	,	,
cord-275433-58unu79x	92	23	redistributing	redistribute	VBG
cord-275433-58unu79x	92	24	between	between	IN
cord-275433-58unu79x	92	25	a	a	DT
cord-275433-58unu79x	92	26	resting	rest	VBG
cord-275433-58unu79x	92	27	location	location	NN
cord-275433-58unu79x	92	28	to	to	IN
cord-275433-58unu79x	92	29	autophagosomes	autophagosomes	VB
cord-275433-58unu79x	92	30	in	in	IN
cord-275433-58unu79x	92	31	an	an	DT
cord-275433-58unu79x	92	32	ATG1-and	ATG1-and	NNP
cord-275433-58unu79x	92	33	PI3K	pi3k	NN
cord-275433-58unu79x	92	34	-	-	HYPH
cord-275433-58unu79x	92	35	dependent	dependent	JJ
cord-275433-58unu79x	92	36	manner	manner	NN
cord-275433-58unu79x	92	37	.	.	.
cord-275433-58unu79x	93	1	ATG9	atg9	JJ
cord-275433-58unu79x	93	2	redistribution	redistribution	NN
cord-275433-58unu79x	93	3	may	may	MD
cord-275433-58unu79x	93	4	depend	depend	VB
cord-275433-58unu79x	93	5	on	on	IN
cord-275433-58unu79x	93	6	ATG18	ATG18	NNP
cord-275433-58unu79x	93	7	,	,	,
cord-275433-58unu79x	93	8	which	which	WDT
cord-275433-58unu79x	93	9	binds	bind	VBZ
cord-275433-58unu79x	93	10	phosphatidylinositol-3-phosphate	phosphatidylinositol-3-phosphate	NNP
cord-275433-58unu79x	93	11	(	(	-LRB-
cord-275433-58unu79x	93	12	PtdIns3P	PtdIns3P	NNP
cord-275433-58unu79x	93	13	)	)	-RRB-
cord-275433-58unu79x	93	14	.	.	.
cord-275433-58unu79x	94	1	b	b	LS
cord-275433-58unu79x	94	2	|	|	NNP
cord-275433-58unu79x	95	1	The	the	DT
cord-275433-58unu79x	95	2	elongation	elongation	NN
cord-275433-58unu79x	95	3	and	and	CC
cord-275433-58unu79x	95	4	shape	shape	NN
cord-275433-58unu79x	95	5	of	of	IN
cord-275433-58unu79x	95	6	the	the	DT
cord-275433-58unu79x	95	7	autophagosome	autophagosome	NNP
cord-275433-58unu79x	95	8	are	be	VBP
cord-275433-58unu79x	95	9	controlled	control	VBN
cord-275433-58unu79x	95	10	by	by	IN
cord-275433-58unu79x	95	11	two	two	CD
cord-275433-58unu79x	95	12	protein	protein	NN
cord-275433-58unu79x	95	13	(	(	-LRB-
cord-275433-58unu79x	95	14	and	and	CC
cord-275433-58unu79x	95	15	lipid	lipid	NN
cord-275433-58unu79x	95	16	)	)	-RRB-
cord-275433-58unu79x	95	17	conjugation	conjugation	NN
cord-275433-58unu79x	95	18	systems	system	NNS
cord-275433-58unu79x	95	19	,	,	,
cord-275433-58unu79x	95	20	similar	similar	JJ
cord-275433-58unu79x	95	21	to	to	IN
cord-275433-58unu79x	95	22	the	the	DT
cord-275433-58unu79x	95	23	ubiquitylation	ubiquitylation	NN
cord-275433-58unu79x	95	24	systems	system	NNS
cord-275433-58unu79x	95	25	:	:	:
cord-275433-58unu79x	95	26	the	the	DT
cord-275433-58unu79x	95	27	ATG12	ATG12	NNP
cord-275433-58unu79x	95	28	and	and	CC
cord-275433-58unu79x	95	29	LC3	LC3	NNP
cord-275433-58unu79x	95	30	(	(	-LRB-
cord-275433-58unu79x	95	31	also	also	RB
cord-275433-58unu79x	95	32	known	know	VBN
cord-275433-58unu79x	95	33	as	as	IN
cord-275433-58unu79x	95	34	ATG8)-phosphatidylethanolamine	atg8)-phosphatidylethanolamine	NN
cord-275433-58unu79x	95	35	(	(	-LRB-
cord-275433-58unu79x	95	36	PE	pe	NN
cord-275433-58unu79x	95	37	)	)	-RRB-
cord-275433-58unu79x	95	38	conjugation	conjugation	NN
cord-275433-58unu79x	95	39	pathways	pathway	NNS
cord-275433-58unu79x	95	40	,	,	,
cord-275433-58unu79x	95	41	which	which	WDT
cord-275433-58unu79x	95	42	include	include	VBP
cord-275433-58unu79x	95	43	E1-activating	e1-activating	NN
cord-275433-58unu79x	95	44	and	and	CC
cord-275433-58unu79x	95	45	E2-conjugating	e2-conjugating	NN
cord-275433-58unu79x	95	46	enzymes	enzyme	NNS
cord-275433-58unu79x	95	47	.	.	.
cord-275433-58unu79x	96	1	ATG12	ATG12	NNP
cord-275433-58unu79x	96	2	is	be	VBZ
cord-275433-58unu79x	96	3	initially	initially	RB
cord-275433-58unu79x	96	4	conjugated	conjugate	VBN
cord-275433-58unu79x	96	5	to	to	IN
cord-275433-58unu79x	96	6	ATG7	ATG7	NNP
cord-275433-58unu79x	96	7	(	(	-LRB-
cord-275433-58unu79x	96	8	an	an	DT
cord-275433-58unu79x	96	9	E1-activating	e1-activating	NN
cord-275433-58unu79x	96	10	enzyme	enzyme	NN
cord-275433-58unu79x	96	11	)	)	-RRB-
cord-275433-58unu79x	96	12	and	and	CC
cord-275433-58unu79x	96	13	then	then	RB
cord-275433-58unu79x	96	14	is	be	VBZ
cord-275433-58unu79x	96	15	transferred	transfer	VBN
cord-275433-58unu79x	96	16	to	to	IN
cord-275433-58unu79x	96	17	the	the	DT
cord-275433-58unu79x	96	18	E2-like	e2-like	NN
cord-275433-58unu79x	96	19	conjugating	conjugating	NN
cord-275433-58unu79x	96	20	enzyme	enzyme	NN
cord-275433-58unu79x	96	21	ATG10	ATG10	NNP
cord-275433-58unu79x	96	22	.	.	.
cord-275433-58unu79x	97	1	This	this	DT
cord-275433-58unu79x	97	2	intermediate	intermediate	JJ
cord-275433-58unu79x	97	3	presents	present	VBZ
cord-275433-58unu79x	97	4	ATG12	ATG12	NNP
cord-275433-58unu79x	97	5	for	for	IN
cord-275433-58unu79x	97	6	conjugation	conjugation	NN
cord-275433-58unu79x	97	7	to	to	IN
cord-275433-58unu79x	97	8	an	an	DT
cord-275433-58unu79x	97	9	ATG5	ATG5	NNP
cord-275433-58unu79x	97	10	lysine	lysine	NN
cord-275433-58unu79x	97	11	residue	residue	NN
cord-275433-58unu79x	97	12	.	.	.
cord-275433-58unu79x	98	1	The	the	DT
cord-275433-58unu79x	98	2	ATG5-ATG12	ATG5-ATG12	NNP
cord-275433-58unu79x	98	3	conjugate	conjugate	NN
cord-275433-58unu79x	98	4	,	,	,
cord-275433-58unu79x	98	5	stabilized	stabilize	VBD
cord-275433-58unu79x	98	6	non	non	NN
cord-275433-58unu79x	98	7	-	-	NN
cord-275433-58unu79x	98	8	covalently	covalently	RB
cord-275433-58unu79x	98	9	by	by	IN
cord-275433-58unu79x	98	10	ATG16	ATG16	NNP
cord-275433-58unu79x	98	11	,	,	,
cord-275433-58unu79x	98	12	triggers	trigger	VBZ
cord-275433-58unu79x	98	13	oligomerization	oligomerization	NN
cord-275433-58unu79x	98	14	on	on	IN
cord-275433-58unu79x	98	15	the	the	DT
cord-275433-58unu79x	98	16	outside	outside	JJ
cord-275433-58unu79x	98	17	membrane	membrane	NN
cord-275433-58unu79x	98	18	of	of	IN
cord-275433-58unu79x	98	19	the	the	DT
cord-275433-58unu79x	98	20	growing	grow	VBG
cord-275433-58unu79x	98	21	autophagosome	autophagosome	NN
cord-275433-58unu79x	98	22	,	,	,
cord-275433-58unu79x	98	23	and	and	CC
cord-275433-58unu79x	98	24	enhances	enhance	VBZ
cord-275433-58unu79x	98	25	LC3	lc3	JJ
cord-275433-58unu79x	98	26	carboxy	carboxy	JJ
cord-275433-58unu79x	98	27	-	-	HYPH
cord-275433-58unu79x	98	28	terminal	terminal	NN
cord-275433-58unu79x	98	29	lipidation	lipidation	NN
cord-275433-58unu79x	98	30	through	through	IN
cord-275433-58unu79x	98	31	the	the	DT
cord-275433-58unu79x	98	32	LC3	lc3	JJ
cord-275433-58unu79x	98	33	conjugation	conjugation	NN
cord-275433-58unu79x	98	34	system	system	NN
cord-275433-58unu79x	98	35	.	.	.
cord-275433-58unu79x	99	1	Upon	upon	IN
cord-275433-58unu79x	99	2	autophagosome	autophagosome	JJ
cord-275433-58unu79x	99	3	closure	closure	NN
cord-275433-58unu79x	99	4	,	,	,
cord-275433-58unu79x	99	5	ATG5-ATG12-ATG16	atg5-atg12-atg16	JJ
cord-275433-58unu79x	99	6	and	and	CC
cord-275433-58unu79x	99	7	LC3	lc3	JJ
cord-275433-58unu79x	99	8	(	(	-LRB-
cord-275433-58unu79x	99	9	delipidated	delipidate	VBN
cord-275433-58unu79x	99	10	by	by	IN
cord-275433-58unu79x	99	11	ATG4	ATG4	NNP
cord-275433-58unu79x	99	12	)	)	-RRB-
cord-275433-58unu79x	99	13	are	be	VBP
cord-275433-58unu79x	99	14	recycled	recycle	VBN
cord-275433-58unu79x	99	15	.	.	.
cord-275433-58unu79x	100	1	c	c	NNP
cord-275433-58unu79x	100	2	|	|	NNP
cord-275433-58unu79x	100	3	LC3	LC3	NNP
cord-275433-58unu79x	100	4	associated	associate	VBD
cord-275433-58unu79x	100	5	with	with	IN
cord-275433-58unu79x	100	6	the	the	DT
cord-275433-58unu79x	100	7	lumenal	lumenal	JJ
cord-275433-58unu79x	100	8	membrane	membrane	NN
cord-275433-58unu79x	100	9	remains	remain	VBZ
cord-275433-58unu79x	100	10	trapped	trap	VBN
cord-275433-58unu79x	100	11	in	in	IN
cord-275433-58unu79x	100	12	the	the	DT
cord-275433-58unu79x	100	13	autophagosome	autophagosome	NN
cord-275433-58unu79x	100	14	and	and	CC
cord-275433-58unu79x	100	15	is	be	VBZ
cord-275433-58unu79x	100	16	degraded	degrade	VBN
cord-275433-58unu79x	100	17	during	during	IN
cord-275433-58unu79x	100	18	maturation	maturation	NN
cord-275433-58unu79x	100	19	into	into	IN
cord-275433-58unu79x	100	20	the	the	DT
cord-275433-58unu79x	100	21	autolysosome	autolysosome	NN
cord-275433-58unu79x	100	22	,	,	,
cord-275433-58unu79x	100	23	which	which	WDT
cord-275433-58unu79x	100	24	involves	involve	VBZ
cord-275433-58unu79x	100	25	fusion	fusion	NN
cord-275433-58unu79x	100	26	of	of	IN
cord-275433-58unu79x	100	27	autophagosomes	autophagosome	NNS
cord-275433-58unu79x	100	28	with	with	IN
cord-275433-58unu79x	100	29	late	late	JJ
cord-275433-58unu79x	100	30	endosomes	endosome	NNS
cord-275433-58unu79x	100	31	,	,	,
cord-275433-58unu79x	100	32	including	include	VBG
cord-275433-58unu79x	100	33	endosomal	endosomal	NNP
cord-275433-58unu79x	100	34	multivesicular	multivesicular	NNP
cord-275433-58unu79x	100	35	bodies	body	NNS
cord-275433-58unu79x	100	36	and	and	CC
cord-275433-58unu79x	100	37	lysosomal	lysosomal	JJ
cord-275433-58unu79x	100	38	organelles	organelle	NNS
cord-275433-58unu79x	100	39	,	,	,
cord-275433-58unu79x	100	40	and	and	CC
cord-275433-58unu79x	100	41	dissolution	dissolution	NN
cord-275433-58unu79x	100	42	of	of	IN
cord-275433-58unu79x	100	43	the	the	DT
cord-275433-58unu79x	100	44	internal	internal	JJ
cord-275433-58unu79x	100	45	membrane	membrane	NN
cord-275433-58unu79x	100	46	.	.	.
cord-275433-58unu79x	101	1	VPS34	VPS34	NNP
cord-275433-58unu79x	101	2	has	have	VBZ
cord-275433-58unu79x	101	3	a	a	DT
cord-275433-58unu79x	101	4	role	role	NN
cord-275433-58unu79x	101	5	in	in	IN
cord-275433-58unu79x	101	6	the	the	DT
cord-275433-58unu79x	101	7	formation	formation	NN
cord-275433-58unu79x	101	8	of	of	IN
cord-275433-58unu79x	101	9	late	late	JJ
cord-275433-58unu79x	101	10	endosomal	endosomal	NNP
cord-275433-58unu79x	101	11	multivesicular	multivesicular	NNP
cord-275433-58unu79x	101	12	bodies	body	NNS
cord-275433-58unu79x	101	13	and	and	CC
cord-275433-58unu79x	101	14	lysosomal	lysosomal	JJ
cord-275433-58unu79x	101	15	organelles	organelle	NNS
cord-275433-58unu79x	101	16	contributing	contribute	VBG
cord-275433-58unu79x	101	17	to	to	IN
cord-275433-58unu79x	101	18	the	the	DT
cord-275433-58unu79x	101	19	maturation	maturation	NN
cord-275433-58unu79x	101	20	stages	stage	NNS
cord-275433-58unu79x	101	21	of	of	IN
cord-275433-58unu79x	101	22	autophagy	autophagy	NN
cord-275433-58unu79x	101	23	.	.	.
cord-275433-58unu79x	102	1	to	to	TO
cord-275433-58unu79x	102	2	be	be	VB
cord-275433-58unu79x	102	3	disposed	dispose	VBN
cord-275433-58unu79x	102	4	of	of	IN
cord-275433-58unu79x	102	5	by	by	IN
cord-275433-58unu79x	102	6	the	the	DT
cord-275433-58unu79x	102	7	proteasome	proteasome	NN
cord-275433-58unu79x	102	8	)	)	-RRB-
cord-275433-58unu79x	102	9	and	and	CC
cord-275433-58unu79x	102	10	may	may	MD
cord-275433-58unu79x	102	11	deliver	deliver	VB
cord-275433-58unu79x	102	12	them	-PRON-	PRP
cord-275433-58unu79x	102	13	to	to	IN
cord-275433-58unu79x	102	14	autophagosomes	autophagosomes	VB
cord-275433-58unu79x	102	15	for	for	IN
cord-275433-58unu79x	102	16	degradation	degradation	NN
cord-275433-58unu79x	102	17	35	35	CD
cord-275433-58unu79x	102	18	.	.	.
cord-275433-58unu79x	103	1	Although	although	IN
cord-275433-58unu79x	103	2	only	only	RB
cord-275433-58unu79x	103	3	studied	study	VBD
cord-275433-58unu79x	103	4	so	so	RB
cord-275433-58unu79x	103	5	far	far	RB
cord-275433-58unu79x	103	6	in	in	IN
cord-275433-58unu79x	103	7	the	the	DT
cord-275433-58unu79x	103	8	context	context	NN
cord-275433-58unu79x	103	9	of	of	IN
cord-275433-58unu79x	103	10	targeting	target	VBG
cord-275433-58unu79x	103	11	polyubiquitylated	polyubiquitylated	JJ
cord-275433-58unu79x	103	12	protein	protein	NN
cord-275433-58unu79x	103	13	aggregates	aggregate	NNS
cord-275433-58unu79x	103	14	,	,	,
cord-275433-58unu79x	103	15	an	an	DT
cord-275433-58unu79x	103	16	interesting	interesting	JJ
cord-275433-58unu79x	103	17	question	question	NN
cord-275433-58unu79x	103	18	is	be	VBZ
cord-275433-58unu79x	103	19	whether	whether	IN
cord-275433-58unu79x	103	20	LC3	LC3	NNP
cord-275433-58unu79x	103	21	may	may	MD
cord-275433-58unu79x	103	22	interact	interact	VB
cord-275433-58unu79x	103	23	with	with	IN
cord-275433-58unu79x	103	24	p62	p62	NN
cord-275433-58unu79x	103	25	or	or	CC
cord-275433-58unu79x	103	26	other	other	JJ
cord-275433-58unu79x	103	27	proteins	protein	NNS
cord-275433-58unu79x	103	28	to	to	TO
cord-275433-58unu79x	103	29	target	target	VB
cord-275433-58unu79x	103	30	microorganisms	microorganism	NNS
cord-275433-58unu79x	103	31	for	for	IN
cord-275433-58unu79x	103	32	degradation	degradation	NN
cord-275433-58unu79x	103	33	or	or	CC
cord-275433-58unu79x	103	34	antigens	antigen	NNS
cord-275433-58unu79x	103	35	for	for	IN
cord-275433-58unu79x	103	36	presentation	presentation	NN
cord-275433-58unu79x	103	37	through	through	IN
cord-275433-58unu79x	103	38	the	the	DT
cord-275433-58unu79x	103	39	MHC	MHC	NNP
cord-275433-58unu79x	103	40	class	class	NN
cord-275433-58unu79x	103	41	II	II	NNP
cord-275433-58unu79x	103	42	pathway	pathway	NN
cord-275433-58unu79x	103	43	.	.	.
cord-275433-58unu79x	104	1	The	the	DT
cord-275433-58unu79x	104	2	first	first	JJ
cord-275433-58unu79x	104	3	indication	indication	NN
cord-275433-58unu79x	104	4	that	that	IN
cord-275433-58unu79x	104	5	intracellular	intracellular	JJ
cord-275433-58unu79x	104	6	bacteria	bacteria	NNS
cord-275433-58unu79x	104	7	may	may	MD
cord-275433-58unu79x	104	8	be	be	VB
cord-275433-58unu79x	104	9	degraded	degrade	VBN
cord-275433-58unu79x	104	10	by	by	IN
cord-275433-58unu79x	104	11	an	an	DT
cord-275433-58unu79x	104	12	autophagy	autophagy	NN
cord-275433-58unu79x	104	13	-	-	HYPH
cord-275433-58unu79x	104	14	like	like	JJ
cord-275433-58unu79x	104	15	pathway	pathway	NN
cord-275433-58unu79x	104	16	emerged	emerge	VBD
cord-275433-58unu79x	104	17	more	more	JJR
cord-275433-58unu79x	104	18	than	than	IN
cord-275433-58unu79x	104	19	two	two	CD
cord-275433-58unu79x	104	20	decades	decade	NNS
cord-275433-58unu79x	104	21	ago	ago	RB
cord-275433-58unu79x	104	22	in	in	IN
cord-275433-58unu79x	104	23	morphological	morphological	JJ
cord-275433-58unu79x	104	24	studies	study	NNS
cord-275433-58unu79x	104	25	of	of	IN
cord-275433-58unu79x	104	26	polymorphonuclear	polymorphonuclear	NNP
cord-275433-58unu79x	104	27	cells	cell	NNS
cord-275433-58unu79x	104	28	infected	infect	VBN
cord-275433-58unu79x	104	29	with	with	IN
cord-275433-58unu79x	104	30	Rickettsia	Rickettsia	NNP
cord-275433-58unu79x	104	31	conorii	conorii	NNP
cord-275433-58unu79x	104	32	36	36	CD
cord-275433-58unu79x	104	33	.	.	.
cord-275433-58unu79x	105	1	However	however	RB
cord-275433-58unu79x	105	2	,	,	,
cord-275433-58unu79x	105	3	before	before	IN
cord-275433-58unu79x	105	4	the	the	DT
cord-275433-58unu79x	105	5	discovery	discovery	NN
cord-275433-58unu79x	105	6	of	of	IN
cord-275433-58unu79x	105	7	the	the	DT
cord-275433-58unu79x	105	8	components	component	NNS
cord-275433-58unu79x	105	9	of	of	IN
cord-275433-58unu79x	105	10	the	the	DT
cord-275433-58unu79x	105	11	autophagic	autophagic	NNP
cord-275433-58unu79x	105	12	machinery	machinery	NN
cord-275433-58unu79x	105	13	,	,	,
cord-275433-58unu79x	105	14	this	this	DT
cord-275433-58unu79x	105	15	was	be	VBD
cord-275433-58unu79x	105	16	difficult	difficult	JJ
cord-275433-58unu79x	105	17	to	to	TO
cord-275433-58unu79x	105	18	prove	prove	VB
cord-275433-58unu79x	105	19	.	.	.
cord-275433-58unu79x	106	1	There	there	EX
cord-275433-58unu79x	106	2	was	be	VBD
cord-275433-58unu79x	106	3	a	a	DT
cord-275433-58unu79x	106	4	lack	lack	NN
cord-275433-58unu79x	106	5	of	of	IN
cord-275433-58unu79x	106	6	markers	marker	NNS
cord-275433-58unu79x	106	7	to	to	TO
cord-275433-58unu79x	106	8	unequivocally	unequivocally	RB
cord-275433-58unu79x	106	9	identify	identify	VB
cord-275433-58unu79x	106	10	autophagosomes	autophagosome	NNS
cord-275433-58unu79x	106	11	;	;	:
cord-275433-58unu79x	106	12	it	-PRON-	PRP
cord-275433-58unu79x	106	13	was	be	VBD
cord-275433-58unu79x	106	14	difficult	difficult	JJ
cord-275433-58unu79x	106	15	to	to	TO
cord-275433-58unu79x	106	16	follow	follow	VB
cord-275433-58unu79x	106	17	the	the	DT
cord-275433-58unu79x	106	18	dynamic	dynamic	JJ
cord-275433-58unu79x	106	19	fate	fate	NN
cord-275433-58unu79x	106	20	of	of	IN
cord-275433-58unu79x	106	21	intracellular	intracellular	JJ
cord-275433-58unu79x	106	22	bacteria	bacteria	NNS
cord-275433-58unu79x	106	23	;	;	:
cord-275433-58unu79x	106	24	and	and	CC
cord-275433-58unu79x	106	25	it	-PRON-	PRP
cord-275433-58unu79x	106	26	was	be	VBD
cord-275433-58unu79x	106	27	difficult	difficult	JJ
cord-275433-58unu79x	106	28	to	to	TO
cord-275433-58unu79x	106	29	determine	determine	VB
cord-275433-58unu79x	106	30	the	the	DT
cord-275433-58unu79x	106	31	significance	significance	NN
cord-275433-58unu79x	106	32	of	of	IN
cord-275433-58unu79x	106	33	bacterial	bacterial	JJ
cord-275433-58unu79x	106	34	association	association	NN
cord-275433-58unu79x	106	35	with	with	IN
cord-275433-58unu79x	106	36	autophagosomal	autophagosomal	NNP
cord-275433-58unu79x	106	37	membranes	membrane	NNS
cord-275433-58unu79x	106	38	in	in	IN
cord-275433-58unu79x	106	39	host	host	NN
cord-275433-58unu79x	106	40	defence	defence	NN
cord-275433-58unu79x	106	41	.	.	.
cord-275433-58unu79x	107	1	Indeed	indeed	RB
cord-275433-58unu79x	107	2	,	,	,
cord-275433-58unu79x	107	3	several	several	JJ
cord-275433-58unu79x	107	4	studies	study	NNS
cord-275433-58unu79x	107	5	proposed	propose	VBD
cord-275433-58unu79x	107	6	that	that	IN
cord-275433-58unu79x	107	7	autophagy	autophagy	NN
cord-275433-58unu79x	107	8	was	be	VBD
cord-275433-58unu79x	107	9	a	a	DT
cord-275433-58unu79x	107	10	'	'	``
cord-275433-58unu79x	107	11	microorganism	microorganism	NN
cord-275433-58unu79x	107	12	-	-	HYPH
cord-275433-58unu79x	107	13	friendly	friendly	JJ
cord-275433-58unu79x	107	14	process	process	NN
cord-275433-58unu79x	107	15	'	'	''
cord-275433-58unu79x	107	16	that	that	WDT
cord-275433-58unu79x	107	17	supported	support	VBD
cord-275433-58unu79x	107	18	the	the	DT
cord-275433-58unu79x	107	19	intracellular	intracellular	JJ
cord-275433-58unu79x	107	20	survival	survival	NN
cord-275433-58unu79x	107	21	of	of	IN
cord-275433-58unu79x	107	22	certain	certain	JJ
cord-275433-58unu79x	107	23	pathogens	pathogen	NNS
cord-275433-58unu79x	107	24	37	37	CD
cord-275433-58unu79x	107	25	.	.	.
cord-275433-58unu79x	108	1	However	however	RB
cord-275433-58unu79x	108	2	,	,	,
cord-275433-58unu79x	108	3	with	with	IN
cord-275433-58unu79x	108	4	new	new	JJ
cord-275433-58unu79x	108	5	tools	tool	NNS
cord-275433-58unu79x	108	6	available	available	JJ
cord-275433-58unu79x	108	7	to	to	IN
cord-275433-58unu79x	108	8	label	label	VB
cord-275433-58unu79x	108	9	autophagosomes	autophagosomes	NNP
cord-275433-58unu79x	108	10	and	and	CC
cord-275433-58unu79x	108	11	to	to	TO
cord-275433-58unu79x	108	12	inactivate	inactivate	VB
cord-275433-58unu79x	108	13	the	the	DT
cord-275433-58unu79x	108	14	autophagy	autophagy	NN
cord-275433-58unu79x	108	15	pathway	pathway	NN
cord-275433-58unu79x	108	16	in	in	IN
cord-275433-58unu79x	108	17	infected	infected	JJ
cord-275433-58unu79x	108	18	cells	cell	NNS
cord-275433-58unu79x	108	19	,	,	,
cord-275433-58unu79x	108	20	we	-PRON-	PRP
cord-275433-58unu79x	108	21	now	now	RB
cord-275433-58unu79x	108	22	know	know	VBP
cord-275433-58unu79x	108	23	that	that	IN
cord-275433-58unu79x	108	24	autophagy	autophagy	NN
cord-275433-58unu79x	108	25	is	be	VBZ
cord-275433-58unu79x	108	26	an	an	DT
cord-275433-58unu79x	108	27	important	important	JJ
cord-275433-58unu79x	108	28	host	host	NN
cord-275433-58unu79x	108	29	mechanism	mechanism	NN
cord-275433-58unu79x	108	30	for	for	IN
cord-275433-58unu79x	108	31	the	the	DT
cord-275433-58unu79x	108	32	removal	removal	NN
cord-275433-58unu79x	108	33	of	of	IN
cord-275433-58unu79x	108	34	intracellular	intracellular	JJ
cord-275433-58unu79x	108	35	bacteria	bacteria	NNS
cord-275433-58unu79x	108	36	and	and	CC
cord-275433-58unu79x	108	37	protozoans	protozoan	NNS
cord-275433-58unu79x	108	38	,	,	,
cord-275433-58unu79x	108	39	in	in	IN
cord-275433-58unu79x	108	40	keeping	keep	VBG
cord-275433-58unu79x	108	41	with	with	IN
cord-275433-58unu79x	108	42	its	-PRON-	PRP$
cord-275433-58unu79x	108	43	primary	primary	JJ
cord-275433-58unu79x	108	44	function	function	NN
cord-275433-58unu79x	108	45	as	as	IN
cord-275433-58unu79x	108	46	a	a	DT
cord-275433-58unu79x	108	47	cytoplasmic	cytoplasmic	JJ
cord-275433-58unu79x	108	48	clean	clean	JJ
cord-275433-58unu79x	108	49	-	-	HYPH
cord-275433-58unu79x	108	50	up	up	NN
cord-275433-58unu79x	108	51	process	process	NN
cord-275433-58unu79x	108	52	38	38	CD
cord-275433-58unu79x	108	53	(	(	-LRB-
cord-275433-58unu79x	108	54	FIG	fig	NN
cord-275433-58unu79x	108	55	.	.	.
cord-275433-58unu79x	108	56	3	3	CD
cord-275433-58unu79x	108	57	)	)	-RRB-
cord-275433-58unu79x	108	58	.	.	.
cord-275433-58unu79x	109	1	In	in	IN
cord-275433-58unu79x	109	2	parallel	parallel	JJ
cord-275433-58unu79x	109	3	,	,	,
cord-275433-58unu79x	109	4	many	many	JJ
cord-275433-58unu79x	109	5	pathogens	pathogen	NNS
cord-275433-58unu79x	109	6	have	have	VBP
cord-275433-58unu79x	109	7	evolved	evolve	VBN
cord-275433-58unu79x	109	8	strategies	strategy	NNS
cord-275433-58unu79x	109	9	to	to	TO
cord-275433-58unu79x	109	10	protect	protect	VB
cord-275433-58unu79x	109	11	themselves	-PRON-	PRP
cord-275433-58unu79x	109	12	against	against	IN
cord-275433-58unu79x	109	13	autophagy	autophagy	NN
cord-275433-58unu79x	109	14	or	or	CC
cord-275433-58unu79x	109	15	to	to	TO
cord-275433-58unu79x	109	16	harness	harness	VB
cord-275433-58unu79x	109	17	components	component	NNS
cord-275433-58unu79x	109	18	of	of	IN
cord-275433-58unu79x	109	19	the	the	DT
cord-275433-58unu79x	109	20	autophagy	autophagy	NN
cord-275433-58unu79x	109	21	pathway	pathway	NN
cord-275433-58unu79x	109	22	for	for	IN
cord-275433-58unu79x	109	23	their	-PRON-	PRP$
cord-275433-58unu79x	109	24	own	own	JJ
cord-275433-58unu79x	109	25	benefit	benefit	NN
cord-275433-58unu79x	109	26	,	,	,
cord-275433-58unu79x	109	27	although	although	RB
cord-275433-58unu79x	109	28	,	,	,
cord-275433-58unu79x	109	29	in	in	IN
cord-275433-58unu79x	109	30	general	general	JJ
cord-275433-58unu79x	109	31	,	,	,
cord-275433-58unu79x	109	32	the	the	DT
cord-275433-58unu79x	109	33	molecular	molecular	JJ
cord-275433-58unu79x	109	34	details	detail	NNS
cord-275433-58unu79x	109	35	of	of	IN
cord-275433-58unu79x	109	36	such	such	JJ
cord-275433-58unu79x	109	37	strategies	strategy	NNS
cord-275433-58unu79x	109	38	are	be	VBP
cord-275433-58unu79x	109	39	not	not	RB
cord-275433-58unu79x	109	40	well	well	RB
cord-275433-58unu79x	109	41	defined	define	VBN
cord-275433-58unu79x	109	42	37	37	CD
cord-275433-58unu79x	109	43	.	.	.
cord-275433-58unu79x	110	1	One	one	CD
cord-275433-58unu79x	110	2	of	of	IN
cord-275433-58unu79x	110	3	the	the	DT
cord-275433-58unu79x	110	4	initial	initial	JJ
cord-275433-58unu79x	110	5	indications	indication	NNS
cord-275433-58unu79x	110	6	that	that	WDT
cord-275433-58unu79x	110	7	autophagy	autophagy	NN
cord-275433-58unu79x	110	8	may	may	MD
cord-275433-58unu79x	110	9	have	have	VB
cord-275433-58unu79x	110	10	a	a	DT
cord-275433-58unu79x	110	11	role	role	NN
cord-275433-58unu79x	110	12	in	in	IN
cord-275433-58unu79x	110	13	immunity	immunity	NN
cord-275433-58unu79x	110	14	against	against	IN
cord-275433-58unu79x	110	15	intracellular	intracellular	JJ
cord-275433-58unu79x	110	16	bacteria	bacteria	NNS
cord-275433-58unu79x	110	17	was	be	VBD
cord-275433-58unu79x	110	18	provided	provide	VBN
cord-275433-58unu79x	110	19	by	by	IN
cord-275433-58unu79x	110	20	observations	observation	NNS
cord-275433-58unu79x	110	21	regarding	regard	VBG
cord-275433-58unu79x	110	22	the	the	DT
cord-275433-58unu79x	110	23	role	role	NN
cord-275433-58unu79x	110	24	of	of	IN
cord-275433-58unu79x	110	25	PtdIns3P	PtdIns3P	NNS
cord-275433-58unu79x	110	26	in	in	IN
cord-275433-58unu79x	110	27	innate	innate	JJ
cord-275433-58unu79x	110	28	immunity	immunity	NN
cord-275433-58unu79x	110	29	.	.	.
cord-275433-58unu79x	111	1	It	-PRON-	PRP
cord-275433-58unu79x	111	2	was	be	VBD
cord-275433-58unu79x	111	3	known	know	VBN
cord-275433-58unu79x	111	4	that	that	IN
cord-275433-58unu79x	111	5	PtdIns3P	PtdIns3P	NNS
cord-275433-58unu79x	111	6	participated	participate	VBD
cord-275433-58unu79x	111	7	in	in	IN
cord-275433-58unu79x	111	8	phagolysosomal	phagolysosomal	JJ
cord-275433-58unu79x	111	9	biogenesis	biogenesis	NN
cord-275433-58unu79x	111	10	and	and	CC
cord-275433-58unu79x	111	11	microbial	microbial	JJ
cord-275433-58unu79x	111	12	clearance	clearance	NN
cord-275433-58unu79x	111	13	upon	upon	IN
cord-275433-58unu79x	111	14	macrophage	macrophage	NN
cord-275433-58unu79x	111	15	phagocytosis	phagocytosis	NN
cord-275433-58unu79x	111	16	of	of	IN
cord-275433-58unu79x	111	17	microorganisms	microorganism	NNS
cord-275433-58unu79x	111	18	39	39	CD
cord-275433-58unu79x	111	19	,	,	,
cord-275433-58unu79x	111	20	40	40	CD
cord-275433-58unu79x	111	21	.	.	.
cord-275433-58unu79x	112	1	This	this	DT
cord-275433-58unu79x	112	2	link	link	NN
cord-275433-58unu79x	112	3	prompted	prompt	VBD
cord-275433-58unu79x	112	4	investigations	investigation	NNS
cord-275433-58unu79x	112	5	into	into	IN
cord-275433-58unu79x	112	6	a	a	DT
cord-275433-58unu79x	112	7	potential	potential	JJ
cord-275433-58unu79x	112	8	role	role	NN
cord-275433-58unu79x	112	9	of	of	IN
cord-275433-58unu79x	112	10	increased	increase	VBN
cord-275433-58unu79x	112	11	PtdIns3P	PtdIns3P	NNS
cord-275433-58unu79x	112	12	production	production	NN
cord-275433-58unu79x	112	13	41	41	CD
cord-275433-58unu79x	112	14	and	and	CC
cord-275433-58unu79x	112	15	,	,	,
cord-275433-58unu79x	112	16	by	by	IN
cord-275433-58unu79x	112	17	extension	extension	NN
cord-275433-58unu79x	112	18	,	,	,
cord-275433-58unu79x	112	19	autophagy	autophagy	VBP
cord-275433-58unu79x	112	20	42	42	CD
cord-275433-58unu79x	112	21	-as	-as	CD
cord-275433-58unu79x	112	22	PtdIns3P	PtdIns3P	NNS
cord-275433-58unu79x	112	23	is	be	VBZ
cord-275433-58unu79x	112	24	involved	involve	VBN
cord-275433-58unu79x	112	25	in	in	IN
cord-275433-58unu79x	112	26	the	the	DT
cord-275433-58unu79x	112	27	initiation	initiation	NN
cord-275433-58unu79x	112	28	of	of	IN
cord-275433-58unu79x	112	29	autophagy	autophagy	NN
cord-275433-58unu79x	112	30	downstream	downstream	RB
cord-275433-58unu79x	112	31	of	of	IN
cord-275433-58unu79x	112	32	mTOR	mTOR	NNP
cord-275433-58unu79x	112	33	-in	-in	:
cord-275433-58unu79x	112	34	eliminating	eliminate	VBG
cord-275433-58unu79x	112	35	certain	certain	JJ
cord-275433-58unu79x	112	36	intracellular	intracellular	JJ
cord-275433-58unu79x	112	37	pathogens	pathogen	NNS
cord-275433-58unu79x	112	38	,	,	,
cord-275433-58unu79x	112	39	such	such	JJ
cord-275433-58unu79x	112	40	as	as	IN
cord-275433-58unu79x	112	41	Mycobacterium	Mycobacterium	NNP
cord-275433-58unu79x	112	42	tuberculosis	tuberculosis	NN
cord-275433-58unu79x	112	43	,	,	,
cord-275433-58unu79x	112	44	that	that	DT
cord-275433-58unu79x	112	45	block	block	VBP
cord-275433-58unu79x	112	46	normal	normal	JJ
cord-275433-58unu79x	112	47	phagolysosome	phagolysosome	NN
cord-275433-58unu79x	112	48	biogenesis	biogenesis	NN
cord-275433-58unu79x	112	49	.	.	.
cord-275433-58unu79x	113	1	Gutierrez	Gutierrez	NNP
cord-275433-58unu79x	113	2	et	et	NNP
cord-275433-58unu79x	113	3	al	al	NNP
cord-275433-58unu79x	113	4	.	.	NNP
cord-275433-58unu79x	113	5	showed	show	VBD
cord-275433-58unu79x	113	6	that	that	IN
cord-275433-58unu79x	113	7	the	the	DT
cord-275433-58unu79x	113	8	mycobacterial	mycobacterial	NN
cord-275433-58unu79x	113	9	-	-	HYPH
cord-275433-58unu79x	113	10	imposed	impose	VBN
cord-275433-58unu79x	113	11	block	block	NN
cord-275433-58unu79x	113	12	in	in	IN
cord-275433-58unu79x	113	13	phagolysosomal	phagolysosomal	JJ
cord-275433-58unu79x	113	14	maturation	maturation	NN
cord-275433-58unu79x	113	15	can	can	MD
cord-275433-58unu79x	113	16	be	be	VB
cord-275433-58unu79x	113	17	overcome	overcome	VBN
cord-275433-58unu79x	113	18	by	by	IN
cord-275433-58unu79x	113	19	activating	activate	VBG
cord-275433-58unu79x	113	20	cellular	cellular	JJ
cord-275433-58unu79x	113	21	autophagy	autophagy	NN
cord-275433-58unu79x	113	22	,	,	,
cord-275433-58unu79x	113	23	either	either	CC
cord-275433-58unu79x	113	24	through	through	IN
cord-275433-58unu79x	113	25	starvation	starvation	NN
cord-275433-58unu79x	113	26	or	or	CC
cord-275433-58unu79x	113	27	inhibition	inhibition	NN
cord-275433-58unu79x	113	28	of	of	IN
cord-275433-58unu79x	113	29	mTOR	mTOR	NNP
cord-275433-58unu79x	113	30	42	42	CD
cord-275433-58unu79x	113	31	.	.	.
cord-275433-58unu79x	114	1	Nearly	nearly	RB
cord-275433-58unu79x	114	2	simultaneously	simultaneously	RB
cord-275433-58unu79x	114	3	,	,	,
cord-275433-58unu79x	114	4	other	other	JJ
cord-275433-58unu79x	114	5	studies	study	NNS
cord-275433-58unu79x	114	6	determined	determine	VBD
cord-275433-58unu79x	114	7	that	that	IN
cord-275433-58unu79x	114	8	autophagy	autophagy	NN
cord-275433-58unu79x	114	9	can	can	MD
cord-275433-58unu79x	114	10	capture	capture	VB
cord-275433-58unu79x	114	11	intracellular	intracellular	JJ
cord-275433-58unu79x	114	12	bacteria	bacteria	NNS
cord-275433-58unu79x	114	13	that	that	WDT
cord-275433-58unu79x	114	14	lyse	lyse	VBP
cord-275433-58unu79x	114	15	the	the	DT
cord-275433-58unu79x	114	16	phagosome	phagosome	NN
cord-275433-58unu79x	114	17	and	and	CC
cord-275433-58unu79x	114	18	escape	escape	VB
cord-275433-58unu79x	114	19	into	into	IN
cord-275433-58unu79x	114	20	the	the	DT
cord-275433-58unu79x	114	21	cytosol	cytosol	NN
cord-275433-58unu79x	114	22	(	(	-LRB-
cord-275433-58unu79x	114	23	such	such	JJ
cord-275433-58unu79x	114	24	as	as	IN
cord-275433-58unu79x	114	25	Shigella	Shigella	NNP
cord-275433-58unu79x	114	26	spp	spp	NNP
cord-275433-58unu79x	114	27	.	.	.
cord-275433-58unu79x	114	28	)	)	-RRB-
cord-275433-58unu79x	115	1	43	43	CD
cord-275433-58unu79x	115	2	or	or	CC
cord-275433-58unu79x	115	3	extracellular	extracellular	JJ
cord-275433-58unu79x	115	4	bacteria	bacteria	NNS
cord-275433-58unu79x	115	5	that	that	WDT
cord-275433-58unu79x	115	6	manage	manage	VBP
cord-275433-58unu79x	115	7	to	to	TO
cord-275433-58unu79x	115	8	invade	invade	VB
cord-275433-58unu79x	115	9	the	the	DT
cord-275433-58unu79x	115	10	host	host	NN
cord-275433-58unu79x	115	11	cytoplasm	cytoplasm	NN
cord-275433-58unu79x	115	12	(	(	-LRB-
cord-275433-58unu79x	115	13	such	such	JJ
cord-275433-58unu79x	115	14	as	as	IN
cord-275433-58unu79x	115	15	Group	Group	NNP
cord-275433-58unu79x	115	16	A	A	NNP
cord-275433-58unu79x	115	17	Streptococcus	Streptococcus	NNP
cord-275433-58unu79x	115	18	)	)	-RRB-
cord-275433-58unu79x	115	19	44	44	CD
cord-275433-58unu79x	115	20	.	.	.
cord-275433-58unu79x	116	1	Other	other	JJ
cord-275433-58unu79x	116	2	studies	study	NNS
cord-275433-58unu79x	116	3	have	have	VBP
cord-275433-58unu79x	116	4	confirmed	confirm	VBN
cord-275433-58unu79x	116	5	these	these	DT
cord-275433-58unu79x	116	6	initial	initial	JJ
cord-275433-58unu79x	116	7	findings	finding	NNS
cord-275433-58unu79x	116	8	and	and	CC
cord-275433-58unu79x	116	9	extended	extend	VBD
cord-275433-58unu79x	116	10	the	the	DT
cord-275433-58unu79x	116	11	list	list	NN
cord-275433-58unu79x	116	12	of	of	IN
cord-275433-58unu79x	116	13	intracellular	intracellular	JJ
cord-275433-58unu79x	116	14	bacteria	bacteria	NNS
cord-275433-58unu79x	116	15	and	and	CC
cord-275433-58unu79x	116	16	parasites	parasite	NNS
cord-275433-58unu79x	116	17	targeted	target	VBN
cord-275433-58unu79x	116	18	by	by	IN
cord-275433-58unu79x	116	19	autophagy	autophagy	NN
cord-275433-58unu79x	116	20	to	to	TO
cord-275433-58unu79x	116	21	include	include	VB
cord-275433-58unu79x	116	22	Listeria	Listeria	NNP
cord-275433-58unu79x	116	23	monocytogenes	monocytogenes	NNP
cord-275433-58unu79x	116	24	,	,	,
cord-275433-58unu79x	116	25	Salmonella	Salmonella	NNP
cord-275433-58unu79x	116	26	enterica	enterica	NN
cord-275433-58unu79x	116	27	,	,	,
cord-275433-58unu79x	116	28	Francisella	Francisella	NNP
cord-275433-58unu79x	116	29	tularensis	tularensis	NNP
cord-275433-58unu79x	116	30	and	and	CC
cord-275433-58unu79x	116	31	Toxoplasma	Toxoplasma	NNP
cord-275433-58unu79x	116	32	gondii	gondii	NNP
cord-275433-58unu79x	116	33	8	8	CD
cord-275433-58unu79x	116	34	,	,	,
cord-275433-58unu79x	116	35	9	9	CD
cord-275433-58unu79x	116	36	,	,	,
cord-275433-58unu79x	116	37	[	[	-LRB-
cord-275433-58unu79x	116	38	45	45	CD
cord-275433-58unu79x	116	39	]	]	-RRB-
cord-275433-58unu79x	116	40	[	[	-LRB-
cord-275433-58unu79x	116	41	46	46	CD
cord-275433-58unu79x	116	42	]	]	-RRB-
cord-275433-58unu79x	116	43	[	[	-LRB-
cord-275433-58unu79x	116	44	47	47	CD
cord-275433-58unu79x	116	45	]	]	-RRB-
cord-275433-58unu79x	116	46	[	[	-LRB-
cord-275433-58unu79x	116	47	48	48	CD
cord-275433-58unu79x	116	48	]	]	-RRB-
cord-275433-58unu79x	116	49	[	[	-LRB-
cord-275433-58unu79x	116	50	49	49	CD
cord-275433-58unu79x	116	51	]	]	-RRB-
cord-275433-58unu79x	116	52	.	.	.
cord-275433-58unu79x	117	1	There	there	EX
cord-275433-58unu79x	117	2	are	be	VBP
cord-275433-58unu79x	117	3	some	some	DT
cord-275433-58unu79x	117	4	aspects	aspect	NNS
cord-275433-58unu79x	117	5	of	of	IN
cord-275433-58unu79x	117	6	autophagy	autophagy	NN
cord-275433-58unu79x	117	7	that	that	WDT
cord-275433-58unu79x	117	8	may	may	MD
cord-275433-58unu79x	117	9	be	be	VB
cord-275433-58unu79x	117	10	particular	particular	JJ
cord-275433-58unu79x	117	11	to	to	IN
cord-275433-58unu79x	117	12	the	the	DT
cord-275433-58unu79x	117	13	control	control	NN
cord-275433-58unu79x	117	14	of	of	IN
cord-275433-58unu79x	117	15	intracellular	intracellular	JJ
cord-275433-58unu79x	117	16	bacteria	bacteria	NNS
cord-275433-58unu79x	117	17	.	.	.
cord-275433-58unu79x	118	1	First	first	RB
cord-275433-58unu79x	118	2	,	,	,
cord-275433-58unu79x	118	3	the	the	DT
cord-275433-58unu79x	118	4	size	size	NN
cord-275433-58unu79x	118	5	of	of	IN
cord-275433-58unu79x	118	6	autophagosomes	autophagosome	NNS
cord-275433-58unu79x	118	7	that	that	WDT
cord-275433-58unu79x	118	8	engulf	engulf	VBP
cord-275433-58unu79x	118	9	intracellular	intracellular	JJ
cord-275433-58unu79x	118	10	bacteria	bacteria	NNS
cord-275433-58unu79x	118	11	tends	tend	VBZ
cord-275433-58unu79x	118	12	to	to	TO
cord-275433-58unu79x	118	13	be	be	VB
cord-275433-58unu79x	118	14	considerably	considerably	RB
cord-275433-58unu79x	118	15	larger	large	JJR
cord-275433-58unu79x	118	16	than	than	IN
cord-275433-58unu79x	118	17	'	'	``
cord-275433-58unu79x	118	18	typical	typical	JJ
cord-275433-58unu79x	118	19	'	'	''
cord-275433-58unu79x	118	20	autophagosomes	autophagosomes	NN
cord-275433-58unu79x	118	21	(	(	-LRB-
cord-275433-58unu79x	118	22	that	that	RB
cord-275433-58unu79x	118	23	is	is	RB
cord-275433-58unu79x	118	24	,	,	,
cord-275433-58unu79x	118	25	those	those	DT
cord-275433-58unu79x	118	26	clearing	clear	VBG
cord-275433-58unu79x	118	27	up	up	RP
cord-275433-58unu79x	118	28	cytoplasmic	cytoplasmic	JJ
cord-275433-58unu79x	118	29	constituents	constituent	NNS
cord-275433-58unu79x	118	30	)	)	-RRB-
cord-275433-58unu79x	118	31	44	44	CD
cord-275433-58unu79x	118	32	,	,	,
cord-275433-58unu79x	118	33	raising	raise	VBG
cord-275433-58unu79x	118	34	the	the	DT
cord-275433-58unu79x	118	35	possibility	possibility	NN
cord-275433-58unu79x	118	36	that	that	IN
cord-275433-58unu79x	118	37	these	these	DT
cord-275433-58unu79x	118	38	autophagosomes	autophagosome	NNS
cord-275433-58unu79x	118	39	may	may	MD
cord-275433-58unu79x	118	40	have	have	VB
cord-275433-58unu79x	118	41	a	a	DT
cord-275433-58unu79x	118	42	different	different	JJ
cord-275433-58unu79x	118	43	biogenesis	biogenesis	NN
cord-275433-58unu79x	118	44	than	than	IN
cord-275433-58unu79x	118	45	typical	typical	JJ
cord-275433-58unu79x	118	46	autophagosomes	autophagosome	NNS
cord-275433-58unu79x	118	47	.	.	.
cord-275433-58unu79x	119	1	Nevertheless	nevertheless	RB
cord-275433-58unu79x	119	2	,	,	,
cord-275433-58unu79x	119	3	there	there	EX
cord-275433-58unu79x	119	4	are	be	VBP
cord-275433-58unu79x	119	5	similarities	similarity	NNS
cord-275433-58unu79x	119	6	in	in	IN
cord-275433-58unu79x	119	7	size	size	NN
cord-275433-58unu79x	119	8	between	between	IN
cord-275433-58unu79x	119	9	LC3-positive	lc3-positive	JJ
cord-275433-58unu79x	119	10	structures	structure	NNS
cord-275433-58unu79x	119	11	that	that	WDT
cord-275433-58unu79x	119	12	clear	clear	VBP
cord-275433-58unu79x	119	13	large	large	JJ
cord-275433-58unu79x	119	14	protein	protein	NN
cord-275433-58unu79x	119	15	aggregates	aggregate	VBZ
cord-275433-58unu79x	119	16	50	50	CD
cord-275433-58unu79x	119	17	and	and	CC
cord-275433-58unu79x	119	18	the	the	DT
cord-275433-58unu79x	119	19	LC3-positive	lc3-positive	JJ
cord-275433-58unu79x	119	20	bacteria	bacteria	NNS
cord-275433-58unu79x	119	21	-	-	HYPH
cord-275433-58unu79x	119	22	containing	contain	VBG
cord-275433-58unu79x	119	23	autophagosomes	autophagosomes	NNP
cord-275433-58unu79x	119	24	44	44	CD
cord-275433-58unu79x	119	25	.	.	.
cord-275433-58unu79x	120	1	This	this	DT
cord-275433-58unu79x	120	2	suggests	suggest	VBZ
cord-275433-58unu79x	120	3	that	that	IN
cord-275433-58unu79x	120	4	the	the	DT
cord-275433-58unu79x	120	5	formation	formation	NN
cord-275433-58unu79x	120	6	of	of	IN
cord-275433-58unu79x	120	7	these	these	DT
cord-275433-58unu79x	120	8	large	large	JJ
cord-275433-58unu79x	120	9	autophagosomes	autophagosome	NNS
cord-275433-58unu79x	120	10	,	,	,
cord-275433-58unu79x	120	11	if	if	IN
cord-275433-58unu79x	120	12	distinct	distinct	JJ
cord-275433-58unu79x	120	13	from	from	IN
cord-275433-58unu79x	120	14	classical	classical	JJ
cord-275433-58unu79x	120	15	autophagy	autophagy	NN
cord-275433-58unu79x	120	16	,	,	,
cord-275433-58unu79x	120	17	is	be	VBZ
cord-275433-58unu79x	120	18	not	not	RB
cord-275433-58unu79x	120	19	reserved	reserve	VBN
cord-275433-58unu79x	120	20	exclusively	exclusively	RB
cord-275433-58unu79x	120	21	for	for	IN
cord-275433-58unu79x	120	22	microorganisms	microorganism	NNS
cord-275433-58unu79x	120	23	.	.	.
cord-275433-58unu79x	121	1	Another	another	DT
cord-275433-58unu79x	121	2	area	area	NN
cord-275433-58unu79x	121	3	of	of	IN
cord-275433-58unu79x	121	4	debate	debate	NN
cord-275433-58unu79x	121	5	is	be	VBZ
cord-275433-58unu79x	121	6	whether	whether	IN
cord-275433-58unu79x	121	7	autophagosomes	autophagosomes	NNP
cord-275433-58unu79x	121	8	can	can	MD
cord-275433-58unu79x	121	9	only	only	RB
cord-275433-58unu79x	121	10	target	target	VB
cord-275433-58unu79x	121	11	intracellular	intracellular	JJ
cord-275433-58unu79x	121	12	bacteria	bacteria	NNS
cord-275433-58unu79x	121	13	that	that	WDT
cord-275433-58unu79x	121	14	reside	reside	VBP
cord-275433-58unu79x	121	15	in	in	IN
cord-275433-58unu79x	121	16	the	the	DT
cord-275433-58unu79x	121	17	cytosol	cytosol	NN
cord-275433-58unu79x	121	18	or	or	CC
cord-275433-58unu79x	121	19	whether	whether	IN
cord-275433-58unu79x	121	20	they	-PRON-	PRP
cord-275433-58unu79x	121	21	can	can	MD
cord-275433-58unu79x	121	22	sequester	sequester	VB
cord-275433-58unu79x	121	23	pathogens	pathogen	NNS
cord-275433-58unu79x	121	24	that	that	WDT
cord-275433-58unu79x	121	25	reside	reside	VBP
cord-275433-58unu79x	121	26	in	in	IN
cord-275433-58unu79x	121	27	membranous	membranous	JJ
cord-275433-58unu79x	121	28	or	or	CC
cord-275433-58unu79x	121	29	intravacuolar	intravacuolar	NNP
cord-275433-58unu79x	121	30	compartments	compartment	NNS
cord-275433-58unu79x	121	31	42	42	CD
cord-275433-58unu79x	121	32	,	,	,
cord-275433-58unu79x	121	33	44	44	CD
cord-275433-58unu79x	121	34	,	,	,
cord-275433-58unu79x	121	35	48	48	CD
cord-275433-58unu79x	121	36	,	,	,
cord-275433-58unu79x	121	37	51	51	CD
cord-275433-58unu79x	121	38	.	.	.
cord-275433-58unu79x	122	1	As	as	IN
cord-275433-58unu79x	122	2	autophagy	autophagy	NN
cord-275433-58unu79x	122	3	is	be	VBZ
cord-275433-58unu79x	122	4	designed	design	VBN
cord-275433-58unu79x	122	5	to	to	TO
cord-275433-58unu79x	122	6	engulf	engulf	VB
cord-275433-58unu79x	122	7	membranous	membranous	JJ
cord-275433-58unu79x	122	8	organelles	organelle	NNS
cord-275433-58unu79x	122	9	4,38	4,38	CD
cord-275433-58unu79x	122	10	,	,	,
cord-275433-58unu79x	122	11	the	the	DT
cord-275433-58unu79x	122	12	autophagic	autophagic	JJ
cord-275433-58unu79x	122	13	enclosure	enclosure	NN
cord-275433-58unu79x	122	14	of	of	IN
cord-275433-58unu79x	122	15	a	a	DT
cord-275433-58unu79x	122	16	pathogen	pathogen	NN
cord-275433-58unu79x	122	17	within	within	IN
cord-275433-58unu79x	122	18	a	a	DT
cord-275433-58unu79x	122	19	membranous	membranous	JJ
cord-275433-58unu79x	122	20	vacuole	vacuole	NN
cord-275433-58unu79x	122	21	,	,	,
cord-275433-58unu79x	122	22	such	such	JJ
cord-275433-58unu79x	122	23	as	as	IN
cord-275433-58unu79x	122	24	a	a	DT
cord-275433-58unu79x	122	25	phagosome	phagosome	NN
cord-275433-58unu79x	122	26	,	,	,
cord-275433-58unu79x	122	27	should	should	MD
cord-275433-58unu79x	122	28	not	not	RB
cord-275433-58unu79x	122	29	represent	represent	VB
cord-275433-58unu79x	122	30	an	an	DT
cord-275433-58unu79x	122	31	obstacle	obstacle	NN
cord-275433-58unu79x	122	32	to	to	TO
cord-275433-58unu79x	122	33	autophagic	autophagic	VB
cord-275433-58unu79x	122	34	elimination	elimination	NN
cord-275433-58unu79x	122	35	.	.	.
cord-275433-58unu79x	123	1	This	this	DT
cord-275433-58unu79x	123	2	question	question	NN
cord-275433-58unu79x	123	3	has	have	VBZ
cord-275433-58unu79x	123	4	been	be	VBN
cord-275433-58unu79x	123	5	answered	answer	VBN
cord-275433-58unu79x	123	6	experimentally	experimentally	RB
cord-275433-58unu79x	123	7	using	use	VBG
cord-275433-58unu79x	123	8	the	the	DT
cord-275433-58unu79x	123	9	parasite	parasite	NN
cord-275433-58unu79x	123	10	T.	t.	NN
cord-275433-58unu79x	123	11	gondii	gondii	NN
cord-275433-58unu79x	123	12	.	.	.
cord-275433-58unu79x	124	1	In	in	IN
cord-275433-58unu79x	124	2	T.	T.	NNP
cord-275433-58unu79x	124	3	gondiiinfected	gondiiinfecte	VBN
cord-275433-58unu79x	124	4	cells	cell	NNS
cord-275433-58unu79x	124	5	,	,	,
cord-275433-58unu79x	124	6	two	two	CD
cord-275433-58unu79x	124	7	different	different	JJ
cord-275433-58unu79x	124	8	but	but	CC
cord-275433-58unu79x	124	9	equally	equally	RB
cord-275433-58unu79x	124	10	potent	potent	JJ
cord-275433-58unu79x	124	11	pathways	pathway	NNS
cord-275433-58unu79x	124	12	of	of	IN
cord-275433-58unu79x	124	13	autophagic	autophagic	JJ
cord-275433-58unu79x	124	14	elimination	elimination	NN
cord-275433-58unu79x	124	15	of	of	IN
cord-275433-58unu79x	124	16	the	the	DT
cord-275433-58unu79x	124	17	pathogen	pathogen	NN
cord-275433-58unu79x	124	18	operate	operate	VB
cord-275433-58unu79x	124	19	:	:	:
cord-275433-58unu79x	124	20	one	one	NN
cord-275433-58unu79x	124	21	that	that	WDT
cord-275433-58unu79x	124	22	disrupts	disrupt	VBZ
cord-275433-58unu79x	124	23	the	the	DT
cord-275433-58unu79x	124	24	parasitophorous	parasitophorous	JJ
cord-275433-58unu79x	124	25	vacuole	vacuole	NNP
cord-275433-58unu79x	124	26	that	that	WDT
cord-275433-58unu79x	124	27	harbours	harbour	VBZ
cord-275433-58unu79x	124	28	the	the	DT
cord-275433-58unu79x	124	29	protozoan	protozoan	NN
cord-275433-58unu79x	124	30	9	9	CD
cord-275433-58unu79x	124	31	and	and	CC
cord-275433-58unu79x	124	32	the	the	DT
cord-275433-58unu79x	124	33	other	other	JJ
cord-275433-58unu79x	124	34	that	that	WDT
cord-275433-58unu79x	124	35	does	do	VBZ
cord-275433-58unu79x	124	36	not	not	RB
cord-275433-58unu79x	124	37	require	require	VB
cord-275433-58unu79x	124	38	disruption	disruption	NN
cord-275433-58unu79x	124	39	of	of	IN
cord-275433-58unu79x	124	40	the	the	DT
cord-275433-58unu79x	124	41	parasitophorous	parasitophorous	JJ
cord-275433-58unu79x	124	42	vacuole	vacuole	NNP
cord-275433-58unu79x	124	43	8	8	CD
cord-275433-58unu79x	124	44	.	.	.
cord-275433-58unu79x	125	1	Thus	thus	RB
cord-275433-58unu79x	125	2	,	,	,
cord-275433-58unu79x	125	3	encasement	encasement	NN
cord-275433-58unu79x	125	4	of	of	IN
cord-275433-58unu79x	125	5	the	the	DT
cord-275433-58unu79x	125	6	pathogen	pathogen	NN
cord-275433-58unu79x	125	7	in	in	IN
cord-275433-58unu79x	125	8	a	a	DT
cord-275433-58unu79x	125	9	vacuole	vacuole	NN
cord-275433-58unu79x	125	10	does	do	VBZ
cord-275433-58unu79x	125	11	not	not	RB
cord-275433-58unu79x	125	12	seem	seem	VB
cord-275433-58unu79x	125	13	to	to	TO
cord-275433-58unu79x	125	14	represent	represent	VB
cord-275433-58unu79x	125	15	a	a	DT
cord-275433-58unu79x	125	16	physical	physical	JJ
cord-275433-58unu79x	125	17	barrier	barrier	NN
cord-275433-58unu79x	125	18	to	to	TO
cord-275433-58unu79x	125	19	autophagic	autophagic	VB
cord-275433-58unu79x	125	20	capture	capture	NN
cord-275433-58unu79x	125	21	and	and	CC
cord-275433-58unu79x	125	22	elimination	elimination	NN
cord-275433-58unu79x	125	23	.	.	.
cord-275433-58unu79x	126	1	It	-PRON-	PRP
cord-275433-58unu79x	126	2	has	have	VBZ
cord-275433-58unu79x	126	3	been	be	VBN
cord-275433-58unu79x	126	4	proposed	propose	VBN
cord-275433-58unu79x	126	5	that	that	DT
cord-275433-58unu79x	126	6	damage	damage	NN
cord-275433-58unu79x	126	7	to	to	IN
cord-275433-58unu79x	126	8	the	the	DT
cord-275433-58unu79x	126	9	vacuolar	vacuolar	NNP
cord-275433-58unu79x	126	10	membrane	membrane	NN
cord-275433-58unu79x	126	11	containing	contain	VBG
cord-275433-58unu79x	126	12	the	the	DT
cord-275433-58unu79x	126	13	organism	organism	NN
cord-275433-58unu79x	126	14	may	may	MD
cord-275433-58unu79x	126	15	precede	precede	VB
cord-275433-58unu79x	126	16	its	-PRON-	PRP$
cord-275433-58unu79x	126	17	autophagic	autophagic	NN
cord-275433-58unu79x	126	18	sequestration	sequestration	NN
cord-275433-58unu79x	126	19	9	9	CD
cord-275433-58unu79x	126	20	,	,	,
cord-275433-58unu79x	126	21	but	but	CC
cord-275433-58unu79x	126	22	it	-PRON-	PRP
cord-275433-58unu79x	126	23	is	be	VBZ
cord-275433-58unu79x	126	24	not	not	RB
cord-275433-58unu79x	126	25	yet	yet	RB
cord-275433-58unu79x	126	26	known	know	VBN
cord-275433-58unu79x	126	27	whether	whether	IN
cord-275433-58unu79x	126	28	such	such	JJ
cord-275433-58unu79x	126	29	damage	damage	NN
cord-275433-58unu79x	126	30	or	or	CC
cord-275433-58unu79x	126	31	a	a	DT
cord-275433-58unu79x	126	32	molecular	molecular	JJ
cord-275433-58unu79x	126	33	modification	modification	NN
cord-275433-58unu79x	126	34	of	of	IN
cord-275433-58unu79x	126	35	the	the	DT
cord-275433-58unu79x	126	36	target	target	NN
cord-275433-58unu79x	126	37	membrane	membrane	NN
cord-275433-58unu79x	126	38	leads	lead	VBZ
cord-275433-58unu79x	126	39	to	to	TO
cord-275433-58unu79x	126	40	autophagic	autophagic	VB
cord-275433-58unu79x	126	41	uptake	uptake	NN
cord-275433-58unu79x	126	42	.	.	.
cord-275433-58unu79x	127	1	Another	another	DT
cord-275433-58unu79x	127	2	pertinent	pertinent	JJ
cord-275433-58unu79x	127	3	question	question	NN
cord-275433-58unu79x	127	4	is	be	VBZ
cord-275433-58unu79x	127	5	how	how	WRB
cord-275433-58unu79x	127	6	pathogens	pathogen	NNS
cord-275433-58unu79x	127	7	that	that	WDT
cord-275433-58unu79x	127	8	are	be	VBP
cord-275433-58unu79x	127	9	free	free	JJ
cord-275433-58unu79x	127	10	in	in	IN
cord-275433-58unu79x	127	11	the	the	DT
cord-275433-58unu79x	127	12	cytosol	cytosol	NN
cord-275433-58unu79x	127	13	are	be	VBP
cord-275433-58unu79x	127	14	recognized	recognize	VBN
cord-275433-58unu79x	127	15	by	by	IN
cord-275433-58unu79x	127	16	the	the	DT
cord-275433-58unu79x	127	17	autophagic	autophagic	NNP
cord-275433-58unu79x	127	18	machinery	machinery	NN
cord-275433-58unu79x	127	19	.	.	.
cord-275433-58unu79x	128	1	One	one	CD
cord-275433-58unu79x	128	2	possibility	possibility	NN
cord-275433-58unu79x	128	3	is	be	VBZ
cord-275433-58unu79x	128	4	that	that	IN
cord-275433-58unu79x	128	5	microbial	microbial	JJ
cord-275433-58unu79x	128	6	proteins	protein	NNS
cord-275433-58unu79x	128	7	may	may	MD
cord-275433-58unu79x	128	8	be	be	VB
cord-275433-58unu79x	128	9	marked	mark	VBN
cord-275433-58unu79x	128	10	for	for	IN
cord-275433-58unu79x	128	11	autophagy	autophagy	NN
cord-275433-58unu79x	128	12	by	by	IN
cord-275433-58unu79x	128	13	modifications	modification	NNS
cord-275433-58unu79x	128	14	,	,	,
cord-275433-58unu79x	128	15	such	such	JJ
cord-275433-58unu79x	128	16	as	as	IN
cord-275433-58unu79x	128	17	ubiquitylation	ubiquitylation	NN
cord-275433-58unu79x	128	18	,	,	,
cord-275433-58unu79x	128	19	that	that	WDT
cord-275433-58unu79x	128	20	are	be	VBP
cord-275433-58unu79x	128	21	already	already	RB
cord-275433-58unu79x	128	22	known	know	VBN
cord-275433-58unu79x	128	23	to	to	TO
cord-275433-58unu79x	128	24	modify	modify	VB
cord-275433-58unu79x	128	25	bacterial	bacterial	JJ
cord-275433-58unu79x	128	26	products	product	NNS
cord-275433-58unu79x	128	27	52	52	CD
cord-275433-58unu79x	128	28	,	,	,
cord-275433-58unu79x	128	29	or	or	CC
cord-275433-58unu79x	128	30	by	by	IN
cord-275433-58unu79x	128	31	other	other	JJ
cord-275433-58unu79x	128	32	yet	yet	RB
cord-275433-58unu79x	128	33	to	to	TO
cord-275433-58unu79x	128	34	be	be	VB
cord-275433-58unu79x	128	35	identified	identify	VBN
cord-275433-58unu79x	128	36	molecular	molecular	JJ
cord-275433-58unu79x	128	37	tags	tag	NNS
cord-275433-58unu79x	128	38	.	.	.
cord-275433-58unu79x	129	1	Alternatively	alternatively	RB
cord-275433-58unu79x	129	2	(	(	-LRB-
cord-275433-58unu79x	129	3	or	or	CC
cord-275433-58unu79x	129	4	in	in	IN
cord-275433-58unu79x	129	5	addition	addition	NN
cord-275433-58unu79x	129	6	)	)	-RRB-
cord-275433-58unu79x	129	7	,	,	,
cord-275433-58unu79x	129	8	patternrecognition	patternrecognition	NN
cord-275433-58unu79x	129	9	receptors	receptor	NNS
cord-275433-58unu79x	129	10	,	,	,
cord-275433-58unu79x	129	11	such	such	JJ
cord-275433-58unu79x	129	12	as	as	IN
cord-275433-58unu79x	129	13	TLRs	TLRs	NNP
cord-275433-58unu79x	129	14	,	,	,
cord-275433-58unu79x	129	15	NOD	nod	NN
cord-275433-58unu79x	129	16	-	-	HYPH
cord-275433-58unu79x	129	17	like	like	JJ
cord-275433-58unu79x	129	18	receptors	receptor	NNS
cord-275433-58unu79x	129	19	and	and	CC
cord-275433-58unu79x	129	20	RIG-	RIG-	NNP
cord-275433-58unu79x	130	1	I	-PRON-	PRP
cord-275433-58unu79x	130	2	(	(	-LRB-
cord-275433-58unu79x	130	3	retinoic	retinoic	JJ
cord-275433-58unu79x	130	4	-	-	HYPH
cord-275433-58unu79x	130	5	acid	acid	NN
cord-275433-58unu79x	130	6	-	-	HYPH
cord-275433-58unu79x	130	7	inducible	inducible	JJ
cord-275433-58unu79x	130	8	gene	gene	NN
cord-275433-58unu79x	130	9	I)-like	I)-like	NNP
cord-275433-58unu79x	130	10	helicases	helicase	NNS
cord-275433-58unu79x	130	11	,	,	,
cord-275433-58unu79x	130	12	may	may	MD
cord-275433-58unu79x	130	13	recognize	recognize	VB
cord-275433-58unu79x	130	14	pathogen	pathogen	NN
cord-275433-58unu79x	130	15	-	-	HYPH
cord-275433-58unu79x	130	16	associated	associate	VBN
cord-275433-58unu79x	130	17	molecular	molecular	JJ
cord-275433-58unu79x	130	18	patterns	pattern	NNS
cord-275433-58unu79x	130	19	(	(	-LRB-
cord-275433-58unu79x	130	20	PAMPs	pamp	NNS
cord-275433-58unu79x	130	21	)	)	-RRB-
cord-275433-58unu79x	130	22	to	to	TO
cord-275433-58unu79x	130	23	stimulate	stimulate	VB
cord-275433-58unu79x	130	24	autophagy	autophagy	NN
cord-275433-58unu79x	130	25	.	.	.
cord-275433-58unu79x	131	1	A	a	DT
cord-275433-58unu79x	131	2	related	related	JJ
cord-275433-58unu79x	131	3	possibility	possibility	NN
cord-275433-58unu79x	131	4	is	be	VBZ
cord-275433-58unu79x	131	5	that	that	IN
cord-275433-58unu79x	131	6	exposure	exposure	NN
cord-275433-58unu79x	131	7	of	of	IN
cord-275433-58unu79x	131	8	certain	certain	JJ
cord-275433-58unu79x	131	9	epitopes	epitope	NNS
cord-275433-58unu79x	131	10	at	at	IN
cord-275433-58unu79x	131	11	the	the	DT
cord-275433-58unu79x	131	12	surface	surface	NN
cord-275433-58unu79x	131	13	of	of	IN
cord-275433-58unu79x	131	14	a	a	DT
cord-275433-58unu79x	131	15	microorganism	microorganism	NN
cord-275433-58unu79x	131	16	may	may	MD
cord-275433-58unu79x	131	17	be	be	VB
cord-275433-58unu79x	131	18	involved	involve	VBN
cord-275433-58unu79x	131	19	in	in	IN
cord-275433-58unu79x	131	20	microbial	microbial	JJ
cord-275433-58unu79x	131	21	targeting	target	VBG
cord-275433-58unu79x	131	22	to	to	IN
cord-275433-58unu79x	131	23	autophagosomes	autophagosomes	NNP
cord-275433-58unu79x	131	24	.	.	.
cord-275433-58unu79x	132	1	For	for	IN
cord-275433-58unu79x	132	2	example	example	NN
cord-275433-58unu79x	132	3	,	,	,
cord-275433-58unu79x	132	4	exposure	exposure	NN
cord-275433-58unu79x	132	5	of	of	IN
cord-275433-58unu79x	132	6	a	a	DT
cord-275433-58unu79x	132	7	Shigella	Shigella	NNP
cord-275433-58unu79x	132	8	epitope	epitope	NN
cord-275433-58unu79x	132	9	that	that	WDT
cord-275433-58unu79x	132	10	is	be	VBZ
cord-275433-58unu79x	132	11	normally	normally	RB
cord-275433-58unu79x	132	12	unexposed	unexposed	JJ
cord-275433-58unu79x	132	13	(	(	-LRB-
cord-275433-58unu79x	132	14	due	due	IN
cord-275433-58unu79x	132	15	to	to	IN
cord-275433-58unu79x	132	16	masking	mask	VBG
cord-275433-58unu79x	132	17	by	by	IN
cord-275433-58unu79x	132	18	another	another	DT
cord-275433-58unu79x	132	19	Shigella	Shigella	NNP
cord-275433-58unu79x	132	20	-	-	HYPH
cord-275433-58unu79x	132	21	encoded	encode	VBN
cord-275433-58unu79x	132	22	protein	protein	NN
cord-275433-58unu79x	132	23	)	)	-RRB-
cord-275433-58unu79x	132	24	leads	lead	VBZ
cord-275433-58unu79x	132	25	to	to	TO
cord-275433-58unu79x	132	26	autophagic	autophagic	VB
cord-275433-58unu79x	132	27	bacterial	bacterial	JJ
cord-275433-58unu79x	132	28	capture	capture	NN
cord-275433-58unu79x	132	29	in	in	IN
cord-275433-58unu79x	132	30	cells	cell	NNS
cord-275433-58unu79x	132	31	infected	infect	VBN
cord-275433-58unu79x	132	32	with	with	IN
cord-275433-58unu79x	132	33	mutants	mutant	NNS
cord-275433-58unu79x	132	34	lacking	lack	VBG
cord-275433-58unu79x	132	35	the	the	DT
cord-275433-58unu79x	132	36	epitope	epitope	NN
cord-275433-58unu79x	132	37	-	-	HYPH
cord-275433-58unu79x	132	38	masking	mask	VBG
cord-275433-58unu79x	132	39	protein	protein	NN
cord-275433-58unu79x	132	40	43	43	CD
cord-275433-58unu79x	132	41	.	.	.
cord-275433-58unu79x	133	1	Another	another	DT
cord-275433-58unu79x	133	2	possible	possible	JJ
cord-275433-58unu79x	133	3	signal	signal	NN
cord-275433-58unu79x	133	4	that	that	WDT
cord-275433-58unu79x	133	5	links	link	VBZ
cord-275433-58unu79x	133	6	microbial	microbial	JJ
cord-275433-58unu79x	133	7	presence	presence	NN
cord-275433-58unu79x	133	8	and	and	CC
cord-275433-58unu79x	133	9	autophagy	autophagy	NN
cord-275433-58unu79x	133	10	could	could	MD
cord-275433-58unu79x	133	11	be	be	VB
cord-275433-58unu79x	133	12	the	the	DT
cord-275433-58unu79x	133	13	generation	generation	NN
cord-275433-58unu79x	133	14	of	of	IN
cord-275433-58unu79x	133	15	reactive	reactive	JJ
cord-275433-58unu79x	133	16	oxygen	oxygen	NN
cord-275433-58unu79x	133	17	intermediates	intermediate	NNS
cord-275433-58unu79x	133	18	,	,	,
cord-275433-58unu79x	133	19	as	as	IN
cord-275433-58unu79x	133	20	these	these	DT
cord-275433-58unu79x	133	21	are	be	VBP
cord-275433-58unu79x	133	22	often	often	RB
cord-275433-58unu79x	133	23	associated	associate	VBN
cord-275433-58unu79x	133	24	with	with	IN
cord-275433-58unu79x	133	25	pathogen	pathogen	NN
cord-275433-58unu79x	133	26	recognition	recognition	NN
cord-275433-58unu79x	133	27	by	by	IN
cord-275433-58unu79x	133	28	host	host	NN
cord-275433-58unu79x	133	29	cells	cell	NNS
cord-275433-58unu79x	133	30	and	and	CC
cord-275433-58unu79x	133	31	are	be	VBP
cord-275433-58unu79x	133	32	also	also	RB
cord-275433-58unu79x	133	33	known	know	VBN
cord-275433-58unu79x	133	34	to	to	TO
cord-275433-58unu79x	133	35	induce	induce	VB
cord-275433-58unu79x	133	36	autophagy	autophagy	NN
cord-275433-58unu79x	133	37	53	53	CD
cord-275433-58unu79x	133	38	,	,	,
cord-275433-58unu79x	133	39	54	54	CD
cord-275433-58unu79x	133	40	.	.	.
cord-275433-58unu79x	134	1	Future	future	JJ
cord-275433-58unu79x	134	2	research	research	NN
cord-275433-58unu79x	134	3	into	into	IN
cord-275433-58unu79x	134	4	the	the	DT
cord-275433-58unu79x	134	5	mechanisms	mechanism	NNS
cord-275433-58unu79x	134	6	underlying	underlie	VBG
cord-275433-58unu79x	134	7	the	the	DT
cord-275433-58unu79x	134	8	induction	induction	NN
cord-275433-58unu79x	134	9	of	of	IN
cord-275433-58unu79x	134	10	autophagy	autophagy	NN
cord-275433-58unu79x	134	11	by	by	IN
cord-275433-58unu79x	134	12	microorganisms	microorganism	NNS
cord-275433-58unu79x	134	13	and	and	CC
cord-275433-58unu79x	134	14	their	-PRON-	PRP$
cord-275433-58unu79x	134	15	targeting	targeting	NN
cord-275433-58unu79x	134	16	to	to	IN
cord-275433-58unu79x	134	17	autophagosomes	autophagosomes	NNP
cord-275433-58unu79x	134	18	is	be	VBZ
cord-275433-58unu79x	134	19	likely	likely	JJ
cord-275433-58unu79x	134	20	not	not	RB
cord-275433-58unu79x	134	21	only	only	RB
cord-275433-58unu79x	134	22	to	to	TO
cord-275433-58unu79x	134	23	uncover	uncover	VB
cord-275433-58unu79x	134	24	the	the	DT
cord-275433-58unu79x	134	25	specifics	specific	NNS
cord-275433-58unu79x	134	26	of	of	IN
cord-275433-58unu79x	134	27	how	how	WRB
cord-275433-58unu79x	134	28	the	the	DT
cord-275433-58unu79x	134	29	autophagic	autophagic	NNP
cord-275433-58unu79x	134	30	machinery	machinery	NN
cord-275433-58unu79x	134	31	recognizes	recognize	VBZ
cord-275433-58unu79x	134	32	foreign	foreign	JJ
cord-275433-58unu79x	134	33	material	material	NN
cord-275433-58unu79x	134	34	in	in	IN
cord-275433-58unu79x	134	35	the	the	DT
cord-275433-58unu79x	134	36	cytoplasm	cytoplasm	NN
cord-275433-58unu79x	134	37	but	but	CC
cord-275433-58unu79x	134	38	also	also	RB
cord-275433-58unu79x	134	39	may	may	MD
cord-275433-58unu79x	134	40	shed	shed	VB
cord-275433-58unu79x	134	41	light	light	NN
cord-275433-58unu79x	134	42	on	on	IN
cord-275433-58unu79x	134	43	how	how	WRB
cord-275433-58unu79x	134	44	the	the	DT
cord-275433-58unu79x	134	45	autophagic	autophagic	NNP
cord-275433-58unu79x	134	46	machinery	machinery	NN
cord-275433-58unu79x	134	47	detects	detect	VBZ
cord-275433-58unu79x	134	48	the	the	DT
cord-275433-58unu79x	134	49	cell	cell	NN
cord-275433-58unu79x	134	50	's	's	POS
cord-275433-58unu79x	134	51	own	own	JJ
cord-275433-58unu79x	134	52	damaged	damage	VBN
cord-275433-58unu79x	134	53	organelles	organelle	NNS
cord-275433-58unu79x	134	54	,	,	,
cord-275433-58unu79x	134	55	aggregated	aggregate	VBN
cord-275433-58unu79x	134	56	proteins	protein	NNS
cord-275433-58unu79x	134	57	and	and	CC
cord-275433-58unu79x	134	58	other	other	JJ
cord-275433-58unu79x	134	59	cytoplasmic	cytoplasmic	JJ
cord-275433-58unu79x	134	60	targets	target	NNS
cord-275433-58unu79x	134	61	for	for	IN
cord-275433-58unu79x	134	62	lysosomal	lysosomal	JJ
cord-275433-58unu79x	134	63	degradation	degradation	NN
cord-275433-58unu79x	134	64	.	.	.
cord-275433-58unu79x	135	1	The	the	DT
cord-275433-58unu79x	135	2	sequestration	sequestration	NN
cord-275433-58unu79x	135	3	of	of	IN
cord-275433-58unu79x	135	4	intracellular	intracellular	JJ
cord-275433-58unu79x	135	5	pathogens	pathogen	NNS
cord-275433-58unu79x	135	6	during	during	IN
cord-275433-58unu79x	135	7	autophagy	autophagy	NN
cord-275433-58unu79x	135	8	is	be	VBZ
cord-275433-58unu79x	135	9	not	not	RB
cord-275433-58unu79x	135	10	limited	limit	VBN
cord-275433-58unu79x	135	11	to	to	IN
cord-275433-58unu79x	135	12	bacteria	bacteria	NNS
cord-275433-58unu79x	135	13	and	and	CC
cord-275433-58unu79x	135	14	parasites	parasite	NNS
cord-275433-58unu79x	135	15	.	.	.
cord-275433-58unu79x	136	1	Autophagy	Autophagy	NNP
cord-275433-58unu79x	136	2	can	can	MD
cord-275433-58unu79x	136	3	also	also	RB
cord-275433-58unu79x	136	4	capture	capture	VB
cord-275433-58unu79x	136	5	virions	virion	NNS
cord-275433-58unu79x	136	6	that	that	WDT
cord-275433-58unu79x	136	7	are	be	VBP
cord-275433-58unu79x	136	8	newly	newly	RB
cord-275433-58unu79x	136	9	assembled	assemble	VBN
cord-275433-58unu79x	136	10	inside	inside	IN
cord-275433-58unu79x	136	11	their	-PRON-	PRP$
cord-275433-58unu79x	136	12	host	host	NN
cord-275433-58unu79x	136	13	cells	cell	NNS
cord-275433-58unu79x	136	14	.	.	.
cord-275433-58unu79x	137	1	In	in	IN
cord-275433-58unu79x	137	2	neurons	neuron	NNS
cord-275433-58unu79x	137	3	and	and	CC
cord-275433-58unu79x	137	4	fibroblasts	fibroblast	NNS
cord-275433-58unu79x	137	5	infected	infect	VBN
cord-275433-58unu79x	137	6	with	with	IN
cord-275433-58unu79x	137	7	herpes	herpes	NN
cord-275433-58unu79x	137	8	simplex	simplex	NNP
cord-275433-58unu79x	137	9	virus	virus	NN
cord-275433-58unu79x	137	10	-a	-a	:
cord-275433-58unu79x	137	11	DNA	dna	NN
cord-275433-58unu79x	137	12	virus	virus	NN
cord-275433-58unu79x	137	13	that	that	WDT
cord-275433-58unu79x	137	14	replicates	replicate	VBZ
cord-275433-58unu79x	137	15	in	in	IN
cord-275433-58unu79x	137	16	the	the	DT
cord-275433-58unu79x	137	17	nucleus	nucleus	JJ
cord-275433-58unu79x	137	18	-viral	-viral	JJ
cord-275433-58unu79x	137	19	nucleocapsids	nucleocapsid	NNS
cord-275433-58unu79x	137	20	are	be	VBP
cord-275433-58unu79x	137	21	engulfed	engulf	VBN
cord-275433-58unu79x	137	22	by	by	IN
cord-275433-58unu79x	137	23	autophagosomes	autophagosome	NNS
cord-275433-58unu79x	137	24	as	as	IN
cord-275433-58unu79x	137	25	they	-PRON-	PRP
cord-275433-58unu79x	137	26	egress	egress	VBP
cord-275433-58unu79x	137	27	out	out	IN
cord-275433-58unu79x	137	28	of	of	IN
cord-275433-58unu79x	137	29	the	the	DT
cord-275433-58unu79x	137	30	nucleus	nucleus	NN
cord-275433-58unu79x	137	31	into	into	IN
cord-275433-58unu79x	137	32	the	the	DT
cord-275433-58unu79x	137	33	cytoplasm	cytoplasm	NN
cord-275433-58unu79x	137	34	55	55	CD
cord-275433-58unu79x	138	1	(	(	-LRB-
cord-275433-58unu79x	138	2	FIG	FIG	NNP
cord-275433-58unu79x	138	3	.	.	.
cord-275433-58unu79x	138	4	3	3	CD
cord-275433-58unu79x	138	5	)	)	-RRB-
cord-275433-58unu79x	138	6	.	.	.
cord-275433-58unu79x	139	1	It	-PRON-	PRP
cord-275433-58unu79x	139	2	is	be	VBZ
cord-275433-58unu79x	139	3	not	not	RB
cord-275433-58unu79x	139	4	yet	yet	RB
cord-275433-58unu79x	139	5	known	know	VBN
cord-275433-58unu79x	139	6	whether	whether	IN
cord-275433-58unu79x	139	7	autophagy	autophagy	NN
cord-275433-58unu79x	139	8	also	also	RB
cord-275433-58unu79x	139	9	targets	target	VBZ
cord-275433-58unu79x	139	10	viruses	virus	NNS
cord-275433-58unu79x	139	11	during	during	IN
cord-275433-58unu79x	139	12	cell	cell	NN
cord-275433-58unu79x	139	13	entry	entry	NN
cord-275433-58unu79x	139	14	,	,	,
cord-275433-58unu79x	139	15	but	but	CC
cord-275433-58unu79x	139	16	this	this	DT
cord-275433-58unu79x	139	17	seems	seem	VBZ
cord-275433-58unu79x	139	18	probable	probable	JJ
cord-275433-58unu79x	139	19	based	base	VBN
cord-275433-58unu79x	139	20	on	on	IN
cord-275433-58unu79x	139	21	extrapolations	extrapolation	NNS
cord-275433-58unu79x	139	22	from	from	IN
cord-275433-58unu79x	139	23	findings	finding	NNS
cord-275433-58unu79x	139	24	in	in	IN
cord-275433-58unu79x	139	25	bacterial	bacterial	JJ
cord-275433-58unu79x	139	26	systems	system	NNS
cord-275433-58unu79x	139	27	.	.	.
cord-275433-58unu79x	140	1	If	if	IN
cord-275433-58unu79x	140	2	true	true	JJ
cord-275433-58unu79x	140	3	,	,	,
cord-275433-58unu79x	140	4	this	this	DT
cord-275433-58unu79x	140	5	could	could	MD
cord-275433-58unu79x	140	6	explain	explain	VB
cord-275433-58unu79x	140	7	why	why	WRB
cord-275433-58unu79x	140	8	the	the	DT
cord-275433-58unu79x	140	9	ratio	ratio	NN
cord-275433-58unu79x	140	10	of	of	IN
cord-275433-58unu79x	140	11	virus	virus	NN
cord-275433-58unu79x	140	12	particles	particle	NNS
cord-275433-58unu79x	140	13	per	per	IN
cord-275433-58unu79x	140	14	cell	cell	NN
cord-275433-58unu79x	140	15	often	often	RB
cord-275433-58unu79x	140	16	needs	need	VBZ
cord-275433-58unu79x	140	17	to	to	TO
cord-275433-58unu79x	140	18	be	be	VB
cord-275433-58unu79x	140	19	very	very	RB
cord-275433-58unu79x	140	20	high	high	JJ
cord-275433-58unu79x	140	21	for	for	IN
cord-275433-58unu79x	140	22	cells	cell	NNS
cord-275433-58unu79x	140	23	to	to	TO
cord-275433-58unu79x	140	24	become	become	VB
cord-275433-58unu79x	140	25	productively	productively	RB
cord-275433-58unu79x	140	26	infected	infect	VBN
cord-275433-58unu79x	140	27	by	by	IN
cord-275433-58unu79x	140	28	viruses	virus	NNS
cord-275433-58unu79x	140	29	.	.	.
cord-275433-58unu79x	141	1	The	the	DT
cord-275433-58unu79x	141	2	possibilities	possibility	NNS
cord-275433-58unu79x	141	3	for	for	IN
cord-275433-58unu79x	141	4	how	how	WRB
cord-275433-58unu79x	141	5	viruses	virus	NNS
cord-275433-58unu79x	141	6	are	be	VBP
cord-275433-58unu79x	141	7	targeted	target	VBN
cord-275433-58unu79x	141	8	to	to	IN
cord-275433-58unu79x	141	9	autophagosomes	autophagosome	NNS
cord-275433-58unu79x	141	10	are	be	VBP
cord-275433-58unu79x	141	11	conceptually	conceptually	RB
cord-275433-58unu79x	141	12	similar	similar	JJ
cord-275433-58unu79x	141	13	to	to	IN
cord-275433-58unu79x	141	14	those	those	DT
cord-275433-58unu79x	141	15	discussed	discuss	VBN
cord-275433-58unu79x	141	16	previously	previously	RB
cord-275433-58unu79x	141	17	for	for	IN
cord-275433-58unu79x	141	18	intracellular	intracellular	JJ
cord-275433-58unu79x	141	19	pathogens	pathogen	NNS
cord-275433-58unu79x	141	20	in	in	IN
cord-275433-58unu79x	141	21	general	general	JJ
cord-275433-58unu79x	141	22	.	.	.
cord-275433-58unu79x	142	1	However	however	RB
cord-275433-58unu79x	142	2	,	,	,
cord-275433-58unu79x	142	3	the	the	DT
cord-275433-58unu79x	142	4	specific	specific	JJ
cord-275433-58unu79x	142	5	molecules	molecule	NNS
cord-275433-58unu79x	142	6	involved	involve	VBN
cord-275433-58unu79x	142	7	are	be	VBP
cord-275433-58unu79x	142	8	likely	likely	JJ
cord-275433-58unu79x	142	9	to	to	TO
cord-275433-58unu79x	142	10	differ	differ	VB
cord-275433-58unu79x	142	11	given	give	VBN
cord-275433-58unu79x	142	12	the	the	DT
cord-275433-58unu79x	142	13	unique	unique	JJ
cord-275433-58unu79x	142	14	pathogen	pathogen	NN
cord-275433-58unu79x	142	15	-	-	HYPH
cord-275433-58unu79x	142	16	specific	specific	JJ
cord-275433-58unu79x	142	17	receptors	receptor	NNS
cord-275433-58unu79x	142	18	and	and	CC
cord-275433-58unu79x	142	19	PAMPs	pamp	NNS
cord-275433-58unu79x	142	20	that	that	WDT
cord-275433-58unu79x	142	21	recognize	recognize	VBP
cord-275433-58unu79x	142	22	viral	viral	JJ
cord-275433-58unu79x	142	23	versus	versus	IN
cord-275433-58unu79x	142	24	bacterial	bacterial	JJ
cord-275433-58unu79x	142	25	components	component	NNS
cord-275433-58unu79x	142	26	.	.	.
cord-275433-58unu79x	143	1	Similar	similar	JJ
cord-275433-58unu79x	143	2	to	to	IN
cord-275433-58unu79x	143	3	studies	study	NNS
cord-275433-58unu79x	143	4	in	in	IN
cord-275433-58unu79x	143	5	bacteria	bacteria	NNS
cord-275433-58unu79x	143	6	,	,	,
cord-275433-58unu79x	143	7	several	several	JJ
cord-275433-58unu79x	143	8	investigators	investigator	NNS
cord-275433-58unu79x	143	9	have	have	VBP
cord-275433-58unu79x	143	10	also	also	RB
cord-275433-58unu79x	143	11	proposed	propose	VBN
cord-275433-58unu79x	143	12	that	that	IN
cord-275433-58unu79x	143	13	autophagy	autophagy	NN
cord-275433-58unu79x	143	14	may	may	MD
cord-275433-58unu79x	143	15	be	be	VB
cord-275433-58unu79x	143	16	a	a	DT
cord-275433-58unu79x	143	17	'	'	``
cord-275433-58unu79x	143	18	virus	virus	NN
cord-275433-58unu79x	143	19	-	-	HYPH
cord-275433-58unu79x	143	20	friendly	friendly	JJ
cord-275433-58unu79x	143	21	'	'	''
cord-275433-58unu79x	143	22	pathway	pathway	NN
cord-275433-58unu79x	143	23	,	,	,
cord-275433-58unu79x	143	24	as	as	IN
cord-275433-58unu79x	143	25	it	-PRON-	PRP
cord-275433-58unu79x	143	26	can	can	MD
cord-275433-58unu79x	143	27	provide	provide	VB
cord-275433-58unu79x	143	28	viruses	virus	NNS
cord-275433-58unu79x	143	29	with	with	IN
cord-275433-58unu79x	143	30	a	a	DT
cord-275433-58unu79x	143	31	source	source	NN
cord-275433-58unu79x	143	32	of	of	IN
cord-275433-58unu79x	143	33	intracellular	intracellular	JJ
cord-275433-58unu79x	143	34	membrane	membrane	NN
cord-275433-58unu79x	143	35	that	that	WDT
cord-275433-58unu79x	143	36	serves	serve	VBZ
cord-275433-58unu79x	143	37	as	as	IN
cord-275433-58unu79x	143	38	a	a	DT
cord-275433-58unu79x	143	39	scaffold	scaffold	NN
cord-275433-58unu79x	143	40	for	for	IN
cord-275433-58unu79x	143	41	viral	viral	JJ
cord-275433-58unu79x	143	42	RNA	RNA	NNP
cord-275433-58unu79x	143	43	replication	replication	NN
cord-275433-58unu79x	143	44	complexes	complex	NNS
cord-275433-58unu79x	143	45	,	,	,
cord-275433-58unu79x	143	46	an	an	DT
cord-275433-58unu79x	143	47	event	event	NN
cord-275433-58unu79x	143	48	that	that	WDT
cord-275433-58unu79x	143	49	is	be	VBZ
cord-275433-58unu79x	143	50	necessary	necessary	JJ
cord-275433-58unu79x	143	51	for	for	IN
cord-275433-58unu79x	143	52	efficient	efficient	JJ
cord-275433-58unu79x	143	53	cytoplasmic	cytoplasmic	JJ
cord-275433-58unu79x	143	54	replication	replication	NN
cord-275433-58unu79x	143	55	of	of	IN
cord-275433-58unu79x	143	56	certain	certain	JJ
cord-275433-58unu79x	143	57	viruses	virus	NNS
cord-275433-58unu79x	143	58	37	37	CD
cord-275433-58unu79x	143	59	.	.	.
cord-275433-58unu79x	144	1	So	so	RB
cord-275433-58unu79x	144	2	,	,	,
cord-275433-58unu79x	144	3	similar	similar	JJ
cord-275433-58unu79x	144	4	to	to	IN
cord-275433-58unu79x	144	5	bacteria	bacteria	NNS
cord-275433-58unu79x	144	6	,	,	,
cord-275433-58unu79x	144	7	viruses	virus	NNS
cord-275433-58unu79x	144	8	may	may	MD
cord-275433-58unu79x	144	9	have	have	VB
cord-275433-58unu79x	144	10	also	also	RB
cord-275433-58unu79x	144	11	found	find	VBN
cord-275433-58unu79x	144	12	ways	way	NNS
cord-275433-58unu79x	144	13	to	to	TO
cord-275433-58unu79x	144	14	harness	harness	VB
cord-275433-58unu79x	144	15	the	the	DT
cord-275433-58unu79x	144	16	autophagic	autophagic	JJ
cord-275433-58unu79x	144	17	machinery	machinery	NN
cord-275433-58unu79x	144	18	for	for	IN
cord-275433-58unu79x	144	19	their	-PRON-	PRP$
cord-275433-58unu79x	144	20	own	own	JJ
cord-275433-58unu79x	144	21	replicative	replicative	JJ
cord-275433-58unu79x	144	22	benefit	benefit	NN
cord-275433-58unu79x	144	23	.	.	.
cord-275433-58unu79x	145	1	The	the	DT
cord-275433-58unu79x	145	2	best	well	RBS
cord-275433-58unu79x	145	3	-	-	HYPH
cord-275433-58unu79x	145	4	studied	study	VBN
cord-275433-58unu79x	145	5	examples	example	NNS
cord-275433-58unu79x	145	6	are	be	VBP
cord-275433-58unu79x	145	7	the	the	DT
cord-275433-58unu79x	145	8	mammalian	mammalian	JJ
cord-275433-58unu79x	145	9	picornavirus	picornavirus	NN
cord-275433-58unu79x	145	10	poliovirus	poliovirus	NN
cord-275433-58unu79x	145	11	and	and	CC
cord-275433-58unu79x	145	12	the	the	DT
cord-275433-58unu79x	145	13	murine	murine	JJ
cord-275433-58unu79x	145	14	coronavirus	coronavirus	NN
cord-275433-58unu79x	145	15	mouse	mouse	NN
cord-275433-58unu79x	145	16	hepatitis	hepatitis	NN
cord-275433-58unu79x	145	17	virus	virus	NN
cord-275433-58unu79x	145	18	56	56	CD
cord-275433-58unu79x	145	19	,	,	,
cord-275433-58unu79x	145	20	57	57	CD
cord-275433-58unu79x	145	21	.	.	.
cord-275433-58unu79x	146	1	In	in	IN
cord-275433-58unu79x	146	2	infections	infection	NNS
cord-275433-58unu79x	146	3	with	with	IN
cord-275433-58unu79x	146	4	either	either	DT
cord-275433-58unu79x	146	5	of	of	IN
cord-275433-58unu79x	146	6	these	these	DT
cord-275433-58unu79x	146	7	viruses	virus	NNS
cord-275433-58unu79x	146	8	,	,	,
cord-275433-58unu79x	146	9	knockdown	knockdown	NN
cord-275433-58unu79x	146	10	of	of	IN
cord-275433-58unu79x	146	11	expression	expression	NN
cord-275433-58unu79x	146	12	of	of	IN
cord-275433-58unu79x	146	13	autophagyrelated	autophagyrelated	JJ
cord-275433-58unu79x	146	14	genes	gene	NNS
cord-275433-58unu79x	146	15	reduces	reduce	VBZ
cord-275433-58unu79x	146	16	viral	viral	JJ
cord-275433-58unu79x	146	17	yields	yield	NNS
cord-275433-58unu79x	146	18	.	.	.
cord-275433-58unu79x	147	1	Interestingly	interestingly	RB
cord-275433-58unu79x	147	2	,	,	,
cord-275433-58unu79x	147	3	however	however	RB
cord-275433-58unu79x	147	4	,	,	,
cord-275433-58unu79x	147	5	a	a	DT
cord-275433-58unu79x	147	6	Drosophila	Drosophila	NNP
cord-275433-58unu79x	147	7	melanogaster	melanogaster	NN
cord-275433-58unu79x	147	8	picornavirus	picornavirus	NN
cord-275433-58unu79x	147	9	also	also	RB
cord-275433-58unu79x	147	10	replicates	replicate	VBZ
cord-275433-58unu79x	147	11	in	in	IN
cord-275433-58unu79x	147	12	association	association	NN
cord-275433-58unu79x	147	13	with	with	IN
cord-275433-58unu79x	147	14	double	double	JJ
cord-275433-58unu79x	147	15	-	-	HYPH
cord-275433-58unu79x	147	16	membrane	membrane	NN
cord-275433-58unu79x	147	17	vacuoles	vacuole	NNS
cord-275433-58unu79x	147	18	(	(	-LRB-
cord-275433-58unu79x	147	19	which	which	WDT
cord-275433-58unu79x	147	20	are	be	VBP
cord-275433-58unu79x	147	21	morphologically	morphologically	RB
cord-275433-58unu79x	147	22	similar	similar	JJ
cord-275433-58unu79x	147	23	to	to	IN
cord-275433-58unu79x	147	24	the	the	DT
cord-275433-58unu79x	147	25	'	'	``
cord-275433-58unu79x	147	26	autophagy	autophagy	NN
cord-275433-58unu79x	147	27	-	-	:
cord-275433-58unu79x	147	28	like	like	JJ
cord-275433-58unu79x	147	29	'	'	``
cord-275433-58unu79x	147	30	double	double	JJ
cord-275433-58unu79x	147	31	-	-	HYPH
cord-275433-58unu79x	147	32	membrane	membrane	NN
cord-275433-58unu79x	147	33	vacuoles	vacuole	NNS
cord-275433-58unu79x	147	34	associated	associate	VBN
cord-275433-58unu79x	147	35	with	with	IN
cord-275433-58unu79x	147	36	mammalian	mammalian	JJ
cord-275433-58unu79x	147	37	picornavirus	picornavirus	NN
cord-275433-58unu79x	147	38	replication	replication	NN
cord-275433-58unu79x	147	39	)	)	-RRB-
cord-275433-58unu79x	148	1	but	but	CC
cord-275433-58unu79x	148	2	autophagy	autophagy	NN
cord-275433-58unu79x	148	3	genes	gene	NNS
cord-275433-58unu79x	148	4	are	be	VBP
cord-275433-58unu79x	148	5	not	not	RB
cord-275433-58unu79x	148	6	required	require	VBN
cord-275433-58unu79x	148	7	for	for	IN
cord-275433-58unu79x	148	8	its	-PRON-	PRP$
cord-275433-58unu79x	148	9	normal	normal	JJ
cord-275433-58unu79x	148	10	replication	replication	NN
cord-275433-58unu79x	148	11	58	58	CD
cord-275433-58unu79x	148	12	.	.	.
cord-275433-58unu79x	149	1	This	this	DT
cord-275433-58unu79x	149	2	suggests	suggest	VBZ
cord-275433-58unu79x	149	3	that	that	IN
cord-275433-58unu79x	149	4	the	the	DT
cord-275433-58unu79x	149	5	requirement	requirement	NN
cord-275433-58unu79x	149	6	for	for	IN
cord-275433-58unu79x	149	7	the	the	DT
cord-275433-58unu79x	149	8	autophagic	autophagic	NNP
cord-275433-58unu79x	149	9	machinery	machinery	NN
cord-275433-58unu79x	149	10	in	in	IN
cord-275433-58unu79x	149	11	the	the	DT
cord-275433-58unu79x	149	12	generation	generation	NN
cord-275433-58unu79x	149	13	of	of	IN
cord-275433-58unu79x	149	14	double	double	JJ
cord-275433-58unu79x	149	15	-	-	HYPH
cord-275433-58unu79x	149	16	membrane	membrane	NN
cord-275433-58unu79x	149	17	vacuoles	vacuole	NNS
cord-275433-58unu79x	149	18	that	that	WDT
cord-275433-58unu79x	149	19	support	support	VBP
cord-275433-58unu79x	149	20	picornavirus	picornavirus	NN
cord-275433-58unu79x	149	21	replication	replication	NN
cord-275433-58unu79x	149	22	may	may	MD
cord-275433-58unu79x	149	23	be	be	VB
cord-275433-58unu79x	149	24	cell	cell	NN
cord-275433-58unu79x	149	25	-	-	HYPH
cord-275433-58unu79x	149	26	type	type	NN
cord-275433-58unu79x	149	27	specific	specific	JJ
cord-275433-58unu79x	149	28	or	or	CC
cord-275433-58unu79x	149	29	restricted	restrict	VBN
cord-275433-58unu79x	149	30	to	to	IN
cord-275433-58unu79x	149	31	certain	certain	JJ
cord-275433-58unu79x	149	32	phylogenetic	phylogenetic	JJ
cord-275433-58unu79x	149	33	hosts	host	NNS
cord-275433-58unu79x	149	34	.	.	.
cord-275433-58unu79x	150	1	Furthermore	furthermore	RB
cord-275433-58unu79x	150	2	,	,	,
cord-275433-58unu79x	150	3	the	the	DT
cord-275433-58unu79x	150	4	replication	replication	NN
cord-275433-58unu79x	150	5	of	of	IN
cord-275433-58unu79x	150	6	vaccinia	vaccinia	NN
cord-275433-58unu79x	150	7	virus	virus	NN
cord-275433-58unu79x	150	8	,	,	,
cord-275433-58unu79x	150	9	a	a	DT
cord-275433-58unu79x	150	10	DNA	dna	NN
cord-275433-58unu79x	150	11	virus	virus	NN
cord-275433-58unu79x	150	12	that	that	WDT
cord-275433-58unu79x	150	13	replicates	replicate	VBZ
cord-275433-58unu79x	150	14	in	in	IN
cord-275433-58unu79x	150	15	the	the	DT
cord-275433-58unu79x	150	16	cytoplasm	cytoplasm	NN
cord-275433-58unu79x	150	17	in	in	IN
cord-275433-58unu79x	150	18	association	association	NN
cord-275433-58unu79x	150	19	with	with	IN
cord-275433-58unu79x	150	20	double	double	JJ
cord-275433-58unu79x	150	21	-	-	HYPH
cord-275433-58unu79x	150	22	membrane	membrane	NN
cord-275433-58unu79x	150	23	vacuoles	vacuole	NNS
cord-275433-58unu79x	150	24	,	,	,
cord-275433-58unu79x	150	25	also	also	RB
cord-275433-58unu79x	150	26	does	do	VBZ
cord-275433-58unu79x	150	27	not	not	RB
cord-275433-58unu79x	150	28	require	require	VB
cord-275433-58unu79x	150	29	the	the	DT
cord-275433-58unu79x	150	30	autophagic	autophagic	NNP
cord-275433-58unu79x	150	31	machinery	machinery	NN
cord-275433-58unu79x	150	32	59	59	CD
cord-275433-58unu79x	150	33	.	.	.
cord-275433-58unu79x	151	1	So	so	RB
cord-275433-58unu79x	151	2	,	,	,
cord-275433-58unu79x	151	3	it	-PRON-	PRP
cord-275433-58unu79x	151	4	is	be	VBZ
cord-275433-58unu79x	151	5	unclear	unclear	JJ
cord-275433-58unu79x	151	6	to	to	TO
cord-275433-58unu79x	151	7	what	what	WDT
cord-275433-58unu79x	151	8	extent	extent	NN
cord-275433-58unu79x	151	9	viruses	virus	NNS
cord-275433-58unu79x	151	10	exploit	exploit	VBP
cord-275433-58unu79x	151	11	the	the	DT
cord-275433-58unu79x	151	12	autophagic	autophagic	JJ
cord-275433-58unu79x	151	13	machinery	machinery	NN
cord-275433-58unu79x	151	14	to	to	TO
cord-275433-58unu79x	151	15	obtain	obtain	VB
cord-275433-58unu79x	151	16	membrane	membrane	NN
cord-275433-58unu79x	151	17	anchors	anchor	NNS
cord-275433-58unu79x	151	18	for	for	IN
cord-275433-58unu79x	151	19	their	-PRON-	PRP$
cord-275433-58unu79x	151	20	cytoplasmic	cytoplasmic	JJ
cord-275433-58unu79x	151	21	replication	replication	NN
cord-275433-58unu79x	151	22	.	.	.
cord-275433-58unu79x	152	1	even	even	RB
cord-275433-58unu79x	152	2	in	in	IN
cord-275433-58unu79x	152	3	circumstances	circumstance	NNS
cord-275433-58unu79x	152	4	in	in	IN
cord-275433-58unu79x	152	5	which	which	WDT
cord-275433-58unu79x	152	6	components	component	NNS
cord-275433-58unu79x	152	7	of	of	IN
cord-275433-58unu79x	152	8	the	the	DT
cord-275433-58unu79x	152	9	autophagic	autophagic	NNP
cord-275433-58unu79x	152	10	machinery	machinery	NN
cord-275433-58unu79x	152	11	are	be	VBP
cord-275433-58unu79x	152	12	necessary	necessary	JJ
cord-275433-58unu79x	152	13	for	for	IN
cord-275433-58unu79x	152	14	viral	viral	JJ
cord-275433-58unu79x	152	15	replication	replication	NN
cord-275433-58unu79x	152	16	,	,	,
cord-275433-58unu79x	152	17	it	-PRON-	PRP
cord-275433-58unu79x	152	18	is	be	VBZ
cord-275433-58unu79x	152	19	unknown	unknown	JJ
cord-275433-58unu79x	152	20	whether	whether	IN
cord-275433-58unu79x	152	21	the	the	DT
cord-275433-58unu79x	152	22	viruses	virus	NNS
cord-275433-58unu79x	152	23	are	be	VBP
cord-275433-58unu79x	152	24	truly	truly	RB
cord-275433-58unu79x	152	25	subverting	subvert	VBG
cord-275433-58unu79x	152	26	the	the	DT
cord-275433-58unu79x	152	27	host	host	NN
cord-275433-58unu79x	152	28	autophagic	autophagic	NN
cord-275433-58unu79x	152	29	pathway	pathway	NN
cord-275433-58unu79x	152	30	or	or	CC
cord-275433-58unu79x	152	31	merely	merely	RB
cord-275433-58unu79x	152	32	using	use	VBG
cord-275433-58unu79x	152	33	a	a	DT
cord-275433-58unu79x	152	34	partially	partially	RB
cord-275433-58unu79x	152	35	overlapping	overlap	VBG
cord-275433-58unu79x	152	36	pathway	pathway	NN
cord-275433-58unu79x	152	37	that	that	WDT
cord-275433-58unu79x	152	38	is	be	VBZ
cord-275433-58unu79x	152	39	involved	involve	VBN
cord-275433-58unu79x	152	40	in	in	IN
cord-275433-58unu79x	152	41	membrane	membrane	NN
cord-275433-58unu79x	152	42	trafficking	trafficking	NN
cord-275433-58unu79x	152	43	and	and	CC
cord-275433-58unu79x	152	44	rearrangement	rearrangement	NN
cord-275433-58unu79x	152	45	.	.	.
cord-275433-58unu79x	153	1	Although	although	IN
cord-275433-58unu79x	153	2	there	there	EX
cord-275433-58unu79x	153	3	is	be	VBZ
cord-275433-58unu79x	153	4	perhaps	perhaps	RB
cord-275433-58unu79x	153	5	less	less	RBR
cord-275433-58unu79x	153	6	direct	direct	JJ
cord-275433-58unu79x	153	7	in	in	FW
cord-275433-58unu79x	153	8	vitro	vitro	FW
cord-275433-58unu79x	153	9	evidence	evidence	NN
cord-275433-58unu79x	153	10	for	for	IN
cord-275433-58unu79x	153	11	viruses	virus	NNS
cord-275433-58unu79x	153	12	,	,	,
cord-275433-58unu79x	153	13	compared	compare	VBN
cord-275433-58unu79x	153	14	with	with	IN
cord-275433-58unu79x	153	15	bacteria	bacteria	NNS
cord-275433-58unu79x	153	16	,	,	,
cord-275433-58unu79x	153	17	that	that	WDT
cord-275433-58unu79x	153	18	autophagy	autophagy	NN
cord-275433-58unu79x	153	19	functions	function	NNS
cord-275433-58unu79x	153	20	in	in	IN
cord-275433-58unu79x	153	21	pathogen	pathogen	NN
cord-275433-58unu79x	153	22	elimination	elimination	NN
cord-275433-58unu79x	153	23	,	,	,
cord-275433-58unu79x	153	24	studies	study	NNS
cord-275433-58unu79x	153	25	with	with	IN
cord-275433-58unu79x	153	26	viruses	virus	NNS
cord-275433-58unu79x	153	27	have	have	VBP
cord-275433-58unu79x	153	28	provided	provide	VBN
cord-275433-58unu79x	153	29	the	the	DT
cord-275433-58unu79x	153	30	first	first	JJ
cord-275433-58unu79x	153	31	in	in	IN
cord-275433-58unu79x	153	32	vivo	vivo	NN
cord-275433-58unu79x	153	33	evidence	evidence	NN
cord-275433-58unu79x	153	34	for	for	IN
cord-275433-58unu79x	153	35	a	a	DT
cord-275433-58unu79x	153	36	role	role	NN
cord-275433-58unu79x	153	37	of	of	IN
cord-275433-58unu79x	153	38	autophagy	autophagy	NN
cord-275433-58unu79x	153	39	in	in	IN
cord-275433-58unu79x	153	40	immunity	immunity	NN
cord-275433-58unu79x	153	41	.	.	.
cord-275433-58unu79x	154	1	In	in	IN
cord-275433-58unu79x	154	2	two	two	CD
cord-275433-58unu79x	154	3	different	different	JJ
cord-275433-58unu79x	154	4	phylogenetic	phylogenetic	NN
cord-275433-58unu79x	154	5	kingdoms	kingdom	NNS
cord-275433-58unu79x	154	6	,	,	,
cord-275433-58unu79x	154	7	genetic	genetic	JJ
cord-275433-58unu79x	154	8	manipulation	manipulation	NN
cord-275433-58unu79x	154	9	of	of	IN
cord-275433-58unu79x	154	10	autophagy	autophagy	NN
cord-275433-58unu79x	154	11	-	-	HYPH
cord-275433-58unu79x	154	12	related	relate	VBN
cord-275433-58unu79x	154	13	genes	gene	NNS
cord-275433-58unu79x	154	14	has	have	VBZ
cord-275433-58unu79x	154	15	been	be	VBN
cord-275433-58unu79x	154	16	shown	show	VBN
cord-275433-58unu79x	154	17	to	to	TO
cord-275433-58unu79x	154	18	have	have	VB
cord-275433-58unu79x	154	19	striking	strike	VBG
cord-275433-58unu79x	154	20	effects	effect	NNS
cord-275433-58unu79x	154	21	on	on	IN
cord-275433-58unu79x	154	22	viral	viral	JJ
cord-275433-58unu79x	154	23	diseases	disease	NNS
cord-275433-58unu79x	154	24	.	.	.
cord-275433-58unu79x	155	1	In	in	IN
cord-275433-58unu79x	155	2	plants	plant	NNS
cord-275433-58unu79x	155	3	,	,	,
cord-275433-58unu79x	155	4	RNAi	RNAi	NNS
cord-275433-58unu79x	155	5	-	-	HYPH
cord-275433-58unu79x	155	6	mediated	mediate	VBN
cord-275433-58unu79x	155	7	silencing	silencing	NN
cord-275433-58unu79x	155	8	of	of	IN
cord-275433-58unu79x	155	9	several	several	JJ
cord-275433-58unu79x	155	10	different	different	JJ
cord-275433-58unu79x	155	11	autophagy	autophagy	NN
cord-275433-58unu79x	155	12	-	-	HYPH
cord-275433-58unu79x	155	13	related	relate	VBN
cord-275433-58unu79x	155	14	genes	gene	NNS
cord-275433-58unu79x	155	15	increases	increase	VBZ
cord-275433-58unu79x	155	16	local	local	JJ
cord-275433-58unu79x	155	17	replication	replication	NN
cord-275433-58unu79x	155	18	of	of	IN
cord-275433-58unu79x	155	19	tobacco	tobacco	NN
cord-275433-58unu79x	155	20	mosaic	mosaic	NN
cord-275433-58unu79x	155	21	virus	virus	NN
cord-275433-58unu79x	155	22	and	and	CC
cord-275433-58unu79x	155	23	results	result	NNS
cord-275433-58unu79x	155	24	in	in	IN
cord-275433-58unu79x	155	25	the	the	DT
cord-275433-58unu79x	155	26	uncontrolled	uncontrolled	JJ
cord-275433-58unu79x	155	27	spread	spread	NN
cord-275433-58unu79x	155	28	of	of	IN
cord-275433-58unu79x	155	29	programmed	programmed	JJ
cord-275433-58unu79x	155	30	cell	cell	NN
cord-275433-58unu79x	155	31	death	death	NN
cord-275433-58unu79x	155	32	beyond	beyond	IN
cord-275433-58unu79x	155	33	infected	infected	JJ
cord-275433-58unu79x	155	34	plant	plant	NN
cord-275433-58unu79x	155	35	cells	cell	NNS
cord-275433-58unu79x	155	36	60	60	CD
cord-275433-58unu79x	155	37	.	.	.
cord-275433-58unu79x	156	1	In	in	IN
cord-275433-58unu79x	156	2	mice	mouse	NNS
cord-275433-58unu79x	156	3	,	,	,
cord-275433-58unu79x	156	4	enforced	enforce	VBD
cord-275433-58unu79x	156	5	neuronal	neuronal	JJ
cord-275433-58unu79x	156	6	expression	expression	NN
cord-275433-58unu79x	156	7	of	of	IN
cord-275433-58unu79x	156	8	the	the	DT
cord-275433-58unu79x	156	9	autophagy	autophagy	NN
cord-275433-58unu79x	156	10	-	-	HYPH
cord-275433-58unu79x	156	11	associated	associate	VBN
cord-275433-58unu79x	156	12	protein	protein	NN
cord-275433-58unu79x	156	13	beclin	beclin	NNP
cord-275433-58unu79x	156	14	1	1	CD
cord-275433-58unu79x	156	15	reduces	reduce	VBZ
cord-275433-58unu79x	156	16	alphavirus	alphavirus	NNP
cord-275433-58unu79x	156	17	replication	replication	NN
cord-275433-58unu79x	156	18	and	and	CC
cord-275433-58unu79x	156	19	alphavirus	alphavirus	NN
cord-275433-58unu79x	156	20	-	-	HYPH
cord-275433-58unu79x	156	21	induced	induce	VBN
cord-275433-58unu79x	156	22	neuronal	neuronal	JJ
cord-275433-58unu79x	156	23	apoptosis	apoptosis	NN
cord-275433-58unu79x	156	24	and	and	CC
cord-275433-58unu79x	156	25	protects	protect	VBZ
cord-275433-58unu79x	156	26	mice	mouse	NNS
cord-275433-58unu79x	156	27	from	from	IN
cord-275433-58unu79x	156	28	lethal	lethal	JJ
cord-275433-58unu79x	156	29	virus	virus	NN
cord-275433-58unu79x	156	30	-	-	HYPH
cord-275433-58unu79x	156	31	induced	induce	VBN
cord-275433-58unu79x	156	32	encephalitis	encephalitis	NN
cord-275433-58unu79x	156	33	61	61	CD
cord-275433-58unu79x	156	34	.	.	.
cord-275433-58unu79x	157	1	Together	together	RB
cord-275433-58unu79x	157	2	,	,	,
cord-275433-58unu79x	157	3	these	these	DT
cord-275433-58unu79x	157	4	studies	study	NNS
cord-275433-58unu79x	157	5	suggest	suggest	VBP
cord-275433-58unu79x	157	6	that	that	IN
cord-275433-58unu79x	157	7	autophagy	autophagy	NN
cord-275433-58unu79x	157	8	functions	function	NNS
cord-275433-58unu79x	157	9	in	in	IN
cord-275433-58unu79x	157	10	antiviral	antiviral	JJ
cord-275433-58unu79x	157	11	immunity	immunity	NN
cord-275433-58unu79x	157	12	in	in	IN
cord-275433-58unu79x	157	13	vivo	vivo	NN
cord-275433-58unu79x	157	14	not	not	RB
cord-275433-58unu79x	157	15	only	only	RB
cord-275433-58unu79x	157	16	by	by	IN
cord-275433-58unu79x	157	17	restricting	restrict	VBG
cord-275433-58unu79x	157	18	viral	viral	JJ
cord-275433-58unu79x	157	19	replication	replication	NN
cord-275433-58unu79x	157	20	but	but	CC
cord-275433-58unu79x	157	21	also	also	RB
cord-275433-58unu79x	157	22	by	by	IN
cord-275433-58unu79x	157	23	restricting	restrict	VBG
cord-275433-58unu79x	157	24	pathogen	pathogen	NN
cord-275433-58unu79x	157	25	-	-	HYPH
cord-275433-58unu79x	157	26	induced	induce	VBN
cord-275433-58unu79x	157	27	cell	cell	NN
cord-275433-58unu79x	157	28	death	death	NN
cord-275433-58unu79x	157	29	.	.	.
cord-275433-58unu79x	158	1	The	the	DT
cord-275433-58unu79x	158	2	mechanisms	mechanism	NNS
cord-275433-58unu79x	158	3	underlying	underlie	VBG
cord-275433-58unu79x	158	4	these	these	DT
cord-275433-58unu79x	158	5	protective	protective	JJ
cord-275433-58unu79x	158	6	functions	function	NNS
cord-275433-58unu79x	158	7	of	of	IN
cord-275433-58unu79x	158	8	autophagy	autophagy	NN
cord-275433-58unu79x	158	9	are	be	VBP
cord-275433-58unu79x	158	10	not	not	RB
cord-275433-58unu79x	158	11	yet	yet	RB
cord-275433-58unu79x	158	12	defined	define	VBN
cord-275433-58unu79x	158	13	.	.	.
cord-275433-58unu79x	159	1	In	in	IN
cord-275433-58unu79x	159	2	principle	principle	NN
cord-275433-58unu79x	159	3	,	,	,
cord-275433-58unu79x	159	4	autophagy	autophagy	NN
cord-275433-58unu79x	159	5	may	may	MD
cord-275433-58unu79x	159	6	function	function	VB
cord-275433-58unu79x	159	7	in	in	IN
cord-275433-58unu79x	159	8	the	the	DT
cord-275433-58unu79x	159	9	direct	direct	JJ
cord-275433-58unu79x	159	10	elimination	elimination	NN
cord-275433-58unu79x	159	11	of	of	IN
cord-275433-58unu79x	159	12	viruses	virus	NNS
cord-275433-58unu79x	159	13	(	(	-LRB-
cord-275433-58unu79x	159	14	as	as	IN
cord-275433-58unu79x	159	15	shown	show	VBN
cord-275433-58unu79x	159	16	in	in	IN
cord-275433-58unu79x	159	17	vitro	vitro	FW
cord-275433-58unu79x	159	18	)	)	-RRB-
cord-275433-58unu79x	159	19	,	,	,
cord-275433-58unu79x	159	20	in	in	IN
cord-275433-58unu79x	159	21	the	the	DT
cord-275433-58unu79x	159	22	breakdown	breakdown	NN
cord-275433-58unu79x	159	23	of	of	IN
cord-275433-58unu79x	159	24	host	host	NN
cord-275433-58unu79x	159	25	factors	factor	NNS
cord-275433-58unu79x	159	26	required	require	VBN
cord-275433-58unu79x	159	27	for	for	IN
cord-275433-58unu79x	159	28	viral	viral	JJ
cord-275433-58unu79x	159	29	replication	replication	NN
cord-275433-58unu79x	159	30	or	or	CC
cord-275433-58unu79x	159	31	the	the	DT
cord-275433-58unu79x	159	32	inhibition	inhibition	NN
cord-275433-58unu79x	159	33	of	of	IN
cord-275433-58unu79x	159	34	innate	innate	JJ
cord-275433-58unu79x	159	35	immune	immune	JJ
cord-275433-58unu79x	159	36	signalling	signalling	NN
cord-275433-58unu79x	159	37	,	,	,
cord-275433-58unu79x	159	38	and	and	CC
cord-275433-58unu79x	159	39	in	in	IN
cord-275433-58unu79x	159	40	the	the	DT
cord-275433-58unu79x	159	41	promotion	promotion	NN
cord-275433-58unu79x	159	42	of	of	IN
cord-275433-58unu79x	159	43	cell	cell	NN
cord-275433-58unu79x	159	44	survival	survival	NN
cord-275433-58unu79x	159	45	either	either	CC
cord-275433-58unu79x	159	46	by	by	IN
cord-275433-58unu79x	159	47	maintaining	maintain	VBG
cord-275433-58unu79x	159	48	bioenergetics	bioenergetic	NNS
cord-275433-58unu79x	159	49	in	in	IN
cord-275433-58unu79x	159	50	virally	virally	RB
cord-275433-58unu79x	159	51	infected	infect	VBN
cord-275433-58unu79x	159	52	cells	cell	NNS
cord-275433-58unu79x	159	53	or	or	CC
cord-275433-58unu79x	159	54	by	by	IN
cord-275433-58unu79x	159	55	removing	remove	VBG
cord-275433-58unu79x	159	56	toxic	toxic	JJ
cord-275433-58unu79x	159	57	self	self	NN
cord-275433-58unu79x	159	58	or	or	CC
cord-275433-58unu79x	159	59	viral	viral	JJ
cord-275433-58unu79x	159	60	components	component	NNS
cord-275433-58unu79x	159	61	.	.	.
cord-275433-58unu79x	160	1	As	as	IN
cord-275433-58unu79x	160	2	discussed	discuss	VBN
cord-275433-58unu79x	160	3	in	in	IN
cord-275433-58unu79x	160	4	more	more	JJR
cord-275433-58unu79x	160	5	detail	detail	NN
cord-275433-58unu79x	160	6	later	later	RB
cord-275433-58unu79x	160	7	,	,	,
cord-275433-58unu79x	160	8	autophagy	autophagy	NN
cord-275433-58unu79x	160	9	may	may	MD
cord-275433-58unu79x	160	10	also	also	RB
cord-275433-58unu79x	160	11	promote	promote	VB
cord-275433-58unu79x	160	12	adaptive	adaptive	JJ
cord-275433-58unu79x	160	13	immunity	immunity	NN
cord-275433-58unu79x	160	14	by	by	IN
cord-275433-58unu79x	160	15	the	the	DT
cord-275433-58unu79x	160	16	endogenous	endogenous	JJ
cord-275433-58unu79x	160	17	presentation	presentation	NN
cord-275433-58unu79x	160	18	of	of	IN
cord-275433-58unu79x	160	19	certain	certain	JJ
cord-275433-58unu79x	160	20	viral	viral	JJ
cord-275433-58unu79x	160	21	antigens	antigen	NNS
cord-275433-58unu79x	160	22	through	through	IN
cord-275433-58unu79x	160	23	the	the	DT
cord-275433-58unu79x	160	24	MHC	MHC	NNP
cord-275433-58unu79x	160	25	class	class	NN
cord-275433-58unu79x	160	26	II	II	NNP
cord-275433-58unu79x	160	27	pathway	pathway	NN
cord-275433-58unu79x	160	28	.	.	.
cord-275433-58unu79x	161	1	Moreover	moreover	RB
cord-275433-58unu79x	161	2	,	,	,
cord-275433-58unu79x	161	3	the	the	DT
cord-275433-58unu79x	161	4	role	role	NN
cord-275433-58unu79x	161	5	of	of	IN
cord-275433-58unu79x	161	6	autophagy	autophagy	NN
cord-275433-58unu79x	161	7	in	in	IN
cord-275433-58unu79x	161	8	Peptidome	Peptidome	NNP
cord-275433-58unu79x	162	1	The	the	DT
cord-275433-58unu79x	162	2	repertoire	repertoire	NN
cord-275433-58unu79x	162	3	of	of	IN
cord-275433-58unu79x	162	4	peptides	peptide	NNS
cord-275433-58unu79x	162	5	that	that	WDT
cord-275433-58unu79x	162	6	is	be	VBZ
cord-275433-58unu79x	162	7	presented	present	VBN
cord-275433-58unu79x	162	8	by	by	IN
cord-275433-58unu79x	162	9	antigenpresenting	antigenpresente	VBG
cord-275433-58unu79x	162	10	molecules	molecule	NNS
cord-275433-58unu79x	162	11	.	.	.
cord-275433-58unu79x	163	1	The	the	DT
cord-275433-58unu79x	163	2	process	process	NN
cord-275433-58unu79x	163	3	in	in	IN
cord-275433-58unu79x	163	4	the	the	DT
cord-275433-58unu79x	163	5	thymus	thymus	NN
cord-275433-58unu79x	163	6	that	that	WDT
cord-275433-58unu79x	163	7	selects	select	VBZ
cord-275433-58unu79x	163	8	thymocytes	thymocyte	NNS
cord-275433-58unu79x	163	9	expressing	express	VBG
cord-275433-58unu79x	163	10	T	t	NN
cord-275433-58unu79x	163	11	-	-	HYPH
cord-275433-58unu79x	163	12	cell	cell	NN
cord-275433-58unu79x	163	13	receptors	receptor	NNS
cord-275433-58unu79x	163	14	that	that	WDT
cord-275433-58unu79x	163	15	have	have	VBP
cord-275433-58unu79x	163	16	the	the	DT
cord-275433-58unu79x	163	17	ability	ability	NN
cord-275433-58unu79x	163	18	to	to	TO
cord-275433-58unu79x	163	19	interact	interact	VB
cord-275433-58unu79x	163	20	with	with	IN
cord-275433-58unu79x	163	21	self	self	NN
cord-275433-58unu79x	163	22	MHC	MHC	NNP
cord-275433-58unu79x	163	23	molecules	molecule	NNS
cord-275433-58unu79x	163	24	.	.	.
cord-275433-58unu79x	164	1	The	the	DT
cord-275433-58unu79x	164	2	process	process	NN
cord-275433-58unu79x	164	3	in	in	IN
cord-275433-58unu79x	164	4	the	the	DT
cord-275433-58unu79x	164	5	thymus	thymus	NN
cord-275433-58unu79x	164	6	that	that	WDT
cord-275433-58unu79x	164	7	eliminates	eliminate	VBZ
cord-275433-58unu79x	164	8	T	t	NN
cord-275433-58unu79x	164	9	cells	cell	NNS
cord-275433-58unu79x	164	10	that	that	WDT
cord-275433-58unu79x	164	11	express	express	VBP
cord-275433-58unu79x	164	12	T	t	NN
cord-275433-58unu79x	164	13	-	-	HYPH
cord-275433-58unu79x	164	14	cell	cell	NN
cord-275433-58unu79x	164	15	receptors	receptor	NNS
cord-275433-58unu79x	164	16	with	with	IN
cord-275433-58unu79x	164	17	high	high	JJ
cord-275433-58unu79x	164	18	affinity	affinity	NN
cord-275433-58unu79x	164	19	for	for	IN
cord-275433-58unu79x	164	20	self	self	NN
cord-275433-58unu79x	164	21	antigens	antigen	NNS
cord-275433-58unu79x	164	22	.	.	.
cord-275433-58unu79x	165	1	innate	innate	JJ
cord-275433-58unu79x	165	2	antiviral	antiviral	JJ
cord-275433-58unu79x	165	3	immunity	immunity	NN
cord-275433-58unu79x	165	4	may	may	MD
cord-275433-58unu79x	165	5	not	not	RB
cord-275433-58unu79x	165	6	be	be	VB
cord-275433-58unu79x	165	7	confined	confine	VBN
cord-275433-58unu79x	165	8	to	to	IN
cord-275433-58unu79x	165	9	direct	direct	JJ
cord-275433-58unu79x	165	10	pathogen	pathogen	NN
cord-275433-58unu79x	165	11	elimination	elimination	NN
cord-275433-58unu79x	165	12	.	.	.
cord-275433-58unu79x	166	1	Lee	Lee	NNP
cord-275433-58unu79x	166	2	et	et	NNP
cord-275433-58unu79x	166	3	al	al	NNP
cord-275433-58unu79x	166	4	.	.	.
cord-275433-58unu79x	167	1	recently	recently	RB
cord-275433-58unu79x	167	2	found	find	VBD
cord-275433-58unu79x	167	3	that	that	IN
cord-275433-58unu79x	167	4	the	the	DT
cord-275433-58unu79x	167	5	autophagic	autophagic	NNP
cord-275433-58unu79x	167	6	machinery	machinery	NN
cord-275433-58unu79x	167	7	can	can	MD
cord-275433-58unu79x	167	8	deliver	deliver	VB
cord-275433-58unu79x	167	9	viral	viral	JJ
cord-275433-58unu79x	167	10	nucleic	nucleic	JJ
cord-275433-58unu79x	167	11	acids	acid	NNS
cord-275433-58unu79x	167	12	to	to	IN
cord-275433-58unu79x	167	13	endosomal	endosomal	NNP
cord-275433-58unu79x	167	14	TLRs	TLRs	NNP
cord-275433-58unu79x	167	15	in	in	IN
cord-275433-58unu79x	167	16	plasmacytoid	plasmacytoid	NNP
cord-275433-58unu79x	167	17	dendritic	dendritic	JJ
cord-275433-58unu79x	167	18	cells	cell	NNS
cord-275433-58unu79x	167	19	in	in	IN
cord-275433-58unu79x	167	20	vitro	vitro	FW
cord-275433-58unu79x	167	21	,	,	,
cord-275433-58unu79x	167	22	resulting	result	VBG
cord-275433-58unu79x	167	23	in	in	IN
cord-275433-58unu79x	167	24	type	type	NN
cord-275433-58unu79x	168	1	I	-PRON-	PRP
cord-275433-58unu79x	168	2	IFN	IFN	NNP
cord-275433-58unu79x	168	3	production	production	NN
cord-275433-58unu79x	168	4	12	12	CD
cord-275433-58unu79x	168	5	.	.	.
cord-275433-58unu79x	169	1	Perhaps	perhaps	RB
cord-275433-58unu79x	169	2	autophagy	autophagy	NN
cord-275433-58unu79x	169	3	has	have	VBZ
cord-275433-58unu79x	169	4	a	a	DT
cord-275433-58unu79x	169	5	similar	similar	JJ
cord-275433-58unu79x	169	6	role	role	NN
cord-275433-58unu79x	169	7	in	in	IN
cord-275433-58unu79x	169	8	type	type	NN
cord-275433-58unu79x	170	1	I	-PRON-	PRP
cord-275433-58unu79x	170	2	IFN	IFN	NNP
cord-275433-58unu79x	170	3	production	production	NN
cord-275433-58unu79x	170	4	during	during	IN
cord-275433-58unu79x	170	5	viral	viral	JJ
cord-275433-58unu79x	170	6	infections	infection	NNS
cord-275433-58unu79x	170	7	in	in	IN
cord-275433-58unu79x	170	8	vivo	vivo	NN
cord-275433-58unu79x	170	9	and	and	CC
cord-275433-58unu79x	170	10	in	in	IN
cord-275433-58unu79x	170	11	other	other	JJ
cord-275433-58unu79x	170	12	cell	cell	NN
cord-275433-58unu79x	170	13	types	type	NNS
cord-275433-58unu79x	170	14	infected	infect	VBN
cord-275433-58unu79x	170	15	with	with	IN
cord-275433-58unu79x	170	16	viruses	virus	NNS
cord-275433-58unu79x	170	17	.	.	.
cord-275433-58unu79x	171	1	Another	another	DT
cord-275433-58unu79x	171	2	major	major	JJ
cord-275433-58unu79x	171	3	line	line	NN
cord-275433-58unu79x	171	4	of	of	IN
cord-275433-58unu79x	171	5	evidence	evidence	NN
cord-275433-58unu79x	171	6	that	that	IN
cord-275433-58unu79x	171	7	autophagy	autophagy	NN
cord-275433-58unu79x	171	8	is	be	VBZ
cord-275433-58unu79x	171	9	important	important	JJ
cord-275433-58unu79x	171	10	in	in	IN
cord-275433-58unu79x	171	11	antiviral	antiviral	JJ
cord-275433-58unu79x	171	12	immunity	immunity	NN
cord-275433-58unu79x	171	13	in	in	IN
cord-275433-58unu79x	171	14	vivo	vivo	NN
cord-275433-58unu79x	171	15	is	be	VBZ
cord-275433-58unu79x	171	16	the	the	DT
cord-275433-58unu79x	171	17	recent	recent	JJ
cord-275433-58unu79x	171	18	discovery	discovery	NN
cord-275433-58unu79x	171	19	that	that	IN
cord-275433-58unu79x	171	20	,	,	,
cord-275433-58unu79x	171	21	to	to	TO
cord-275433-58unu79x	171	22	be	be	VB
cord-275433-58unu79x	171	23	pathogenic	pathogenic	JJ
cord-275433-58unu79x	171	24	,	,	,
cord-275433-58unu79x	171	25	viruses	virus	NNS
cord-275433-58unu79x	171	26	may	may	MD
cord-275433-58unu79x	171	27	need	need	VB
cord-275433-58unu79x	171	28	to	to	TO
cord-275433-58unu79x	171	29	successfully	successfully	RB
cord-275433-58unu79x	171	30	counter	counter	VB
cord-275433-58unu79x	171	31	autophagy	autophagy	NN
cord-275433-58unu79x	171	32	.	.	.
cord-275433-58unu79x	172	1	An	an	DT
cord-275433-58unu79x	172	2	essential	essential	JJ
cord-275433-58unu79x	172	3	herpes	herpes	NN
cord-275433-58unu79x	172	4	simplex	simplex	NN
cord-275433-58unu79x	172	5	virus	virus	NN
cord-275433-58unu79x	172	6	neurovirulence	neurovirulence	NNP
cord-275433-58unu79x	172	7	protein	protein	NN
cord-275433-58unu79x	172	8	,	,	,
cord-275433-58unu79x	172	9	ICP34.5	ICP34.5	NNP
cord-275433-58unu79x	172	10	,	,	,
cord-275433-58unu79x	172	11	confers	confer	VBZ
cord-275433-58unu79x	172	12	pathogenicity	pathogenicity	NN
cord-275433-58unu79x	172	13	by	by	IN
cord-275433-58unu79x	172	14	binding	bind	VBG
cord-275433-58unu79x	172	15	to	to	IN
cord-275433-58unu79x	172	16	beclin	beclin	NNP
cord-275433-58unu79x	172	17	1	1	CD
cord-275433-58unu79x	172	18	and	and	CC
cord-275433-58unu79x	172	19	by	by	IN
cord-275433-58unu79x	172	20	antagonizing	antagonize	VBG
cord-275433-58unu79x	172	21	the	the	DT
cord-275433-58unu79x	172	22	host	host	NN
cord-275433-58unu79x	172	23	autophagy	autophagy	NN
cord-275433-58unu79x	172	24	response	response	NN
cord-275433-58unu79x	172	25	62	62	CD
cord-275433-58unu79x	172	26	.	.	.
cord-275433-58unu79x	173	1	Although	although	IN
cord-275433-58unu79x	173	2	this	this	DT
cord-275433-58unu79x	173	3	is	be	VBZ
cord-275433-58unu79x	173	4	the	the	DT
cord-275433-58unu79x	173	5	first	first	JJ
cord-275433-58unu79x	173	6	example	example	NN
cord-275433-58unu79x	173	7	of	of	IN
cord-275433-58unu79x	173	8	a	a	DT
cord-275433-58unu79x	173	9	viral	viral	JJ
cord-275433-58unu79x	173	10	virulence	virulence	NN
cord-275433-58unu79x	173	11	factor	factor	NN
cord-275433-58unu79x	173	12	directly	directly	RB
cord-275433-58unu79x	173	13	targeting	target	VBG
cord-275433-58unu79x	173	14	the	the	DT
cord-275433-58unu79x	173	15	autophagic	autophagic	JJ
cord-275433-58unu79x	173	16	machinery	machinery	NN
cord-275433-58unu79x	173	17	to	to	TO
cord-275433-58unu79x	173	18	elicit	elicit	VB
cord-275433-58unu79x	173	19	disease	disease	NN
cord-275433-58unu79x	173	20	,	,	,
cord-275433-58unu79x	173	21	it	-PRON-	PRP
cord-275433-58unu79x	173	22	seems	seem	VBZ
cord-275433-58unu79x	173	23	probable	probable	JJ
cord-275433-58unu79x	173	24	that	that	IN
cord-275433-58unu79x	173	25	viral	viral	JJ
cord-275433-58unu79x	173	26	evasion	evasion	NN
cord-275433-58unu79x	173	27	of	of	IN
cord-275433-58unu79x	173	28	autophagy	autophagy	NN
cord-275433-58unu79x	173	29	will	will	MD
cord-275433-58unu79x	173	30	prove	prove	VB
cord-275433-58unu79x	173	31	to	to	TO
cord-275433-58unu79x	173	32	be	be	VB
cord-275433-58unu79x	173	33	a	a	DT
cord-275433-58unu79x	173	34	more	more	RBR
cord-275433-58unu79x	173	35	general	general	JJ
cord-275433-58unu79x	173	36	strategy	strategy	NN
cord-275433-58unu79x	173	37	that	that	WDT
cord-275433-58unu79x	173	38	viruses	virus	NNS
cord-275433-58unu79x	173	39	use	use	VBP
cord-275433-58unu79x	173	40	to	to	TO
cord-275433-58unu79x	173	41	evade	evade	VB
cord-275433-58unu79x	173	42	host	host	NN
cord-275433-58unu79x	173	43	antiviral	antiviral	JJ
cord-275433-58unu79x	173	44	defence	defence	NN
cord-275433-58unu79x	173	45	.	.	.
cord-275433-58unu79x	174	1	Other	other	JJ
cord-275433-58unu79x	174	2	viruses	virus	NNS
cord-275433-58unu79x	174	3	encode	encode	VBP
cord-275433-58unu79x	174	4	proteins	protein	NNS
cord-275433-58unu79x	174	5	that	that	WDT
cord-275433-58unu79x	174	6	inhibit	inhibit	VBP
cord-275433-58unu79x	174	7	the	the	DT
cord-275433-58unu79x	174	8	autophagy	autophagy	NN
cord-275433-58unu79x	174	9	function	function	NN
cord-275433-58unu79x	174	10	of	of	IN
cord-275433-58unu79x	174	11	beclin	beclin	NNP
cord-275433-58unu79x	174	12	1	1	CD
cord-275433-58unu79x	174	13	,	,	,
cord-275433-58unu79x	174	14	including	include	VBG
cord-275433-58unu79x	174	15	bCL-2-like	bcl-2-like	NN
cord-275433-58unu79x	174	16	proteins	protein	NNS
cord-275433-58unu79x	174	17	encoded	encode	VBN
cord-275433-58unu79x	174	18	by	by	IN
cord-275433-58unu79x	174	19	the	the	DT
cord-275433-58unu79x	174	20	oncogenic	oncogenic	JJ
cord-275433-58unu79x	174	21	gammaherpesviruses	gammaherpesviruse	NNS
cord-275433-58unu79x	174	22	28	28	CD
cord-275433-58unu79x	174	23	.	.	.
cord-275433-58unu79x	175	1	In	in	IN
cord-275433-58unu79x	175	2	addition	addition	NN
cord-275433-58unu79x	175	3	,	,	,
cord-275433-58unu79x	175	4	numerous	numerous	JJ
cord-275433-58unu79x	175	5	viruses	virus	NNS
cord-275433-58unu79x	175	6	inhibit	inhibit	VBP
cord-275433-58unu79x	175	7	the	the	DT
cord-275433-58unu79x	175	8	PKR	PKR	NNP
cord-275433-58unu79x	175	9	(	(	-LRB-
cord-275433-58unu79x	175	10	IFN	IFN	NNP
cord-275433-58unu79x	175	11	-	-	HYPH
cord-275433-58unu79x	175	12	inducible	inducible	JJ
cord-275433-58unu79x	175	13	doublestranded	doublestranded	NNP
cord-275433-58unu79x	175	14	-	-	HYPH
cord-275433-58unu79x	175	15	RNA	rna	NN
cord-275433-58unu79x	175	16	-	-	HYPH
cord-275433-58unu79x	175	17	dependent	dependent	JJ
cord-275433-58unu79x	175	18	protein	protein	NN
cord-275433-58unu79x	175	19	kinase	kinase	NN
cord-275433-58unu79x	175	20	)	)	-RRB-
cord-275433-58unu79x	175	21	antiviral	antiviral	JJ
cord-275433-58unu79x	175	22	signalling	signal	VBG
cord-275433-58unu79x	175	23	pathway	pathway	NN
cord-275433-58unu79x	175	24	that	that	WDT
cord-275433-58unu79x	175	25	is	be	VBZ
cord-275433-58unu79x	175	26	required	require	VBN
cord-275433-58unu79x	175	27	for	for	IN
cord-275433-58unu79x	175	28	the	the	DT
cord-275433-58unu79x	175	29	induction	induction	NN
cord-275433-58unu79x	175	30	of	of	IN
cord-275433-58unu79x	175	31	autophagy	autophagy	NN
cord-275433-58unu79x	175	32	in	in	IN
cord-275433-58unu79x	175	33	virally	virally	RB
cord-275433-58unu79x	175	34	infected	infect	VBN
cord-275433-58unu79x	175	35	cells	cell	NNS
cord-275433-58unu79x	175	36	or	or	CC
cord-275433-58unu79x	175	37	activate	activate	VBP
cord-275433-58unu79x	175	38	the	the	DT
cord-275433-58unu79x	175	39	autophagy	autophagy	NN
cord-275433-58unu79x	175	40	-	-	HYPH
cord-275433-58unu79x	175	41	inhibitory	inhibitory	JJ
cord-275433-58unu79x	175	42	class	class	NN
cord-275433-58unu79x	175	43	I	i	NN
cord-275433-58unu79x	175	44	PI3K	PI3K	NNP
cord-275433-58unu79x	175	45	-	-	HYPH
cord-275433-58unu79x	175	46	AKT	AKT	NNP
cord-275433-58unu79x	175	47	-	-	HYPH
cord-275433-58unu79x	175	48	mTOR	mTOR	NNP
cord-275433-58unu79x	175	49	signalling	signal	VBG
cord-275433-58unu79x	175	50	pathway	pathway	NN
cord-275433-58unu79x	175	51	63	63	CD
cord-275433-58unu79x	175	52	.	.	.
cord-275433-58unu79x	176	1	The	the	DT
cord-275433-58unu79x	176	2	multiplicity	multiplicity	NN
cord-275433-58unu79x	176	3	of	of	IN
cord-275433-58unu79x	176	4	mechanisms	mechanism	NNS
cord-275433-58unu79x	176	5	that	that	WDT
cord-275433-58unu79x	176	6	diverse	diverse	JJ
cord-275433-58unu79x	176	7	viruses	virus	NNS
cord-275433-58unu79x	176	8	have	have	VBP
cord-275433-58unu79x	176	9	to	to	TO
cord-275433-58unu79x	176	10	turn	turn	VB
cord-275433-58unu79x	176	11	off	off	RP
cord-275433-58unu79x	176	12	autophagy	autophagy	NN
cord-275433-58unu79x	176	13	highlights	highlight	VBZ
cord-275433-58unu79x	176	14	a	a	DT
cord-275433-58unu79x	176	15	probable	probable	JJ
cord-275433-58unu79x	176	16	fundamental	fundamental	JJ
cord-275433-58unu79x	176	17	role	role	NN
cord-275433-58unu79x	176	18	for	for	IN
cord-275433-58unu79x	176	19	autophagy	autophagy	NN
cord-275433-58unu79x	176	20	in	in	IN
cord-275433-58unu79x	176	21	antiviral	antiviral	JJ
cord-275433-58unu79x	176	22	immunity	immunity	NN
cord-275433-58unu79x	176	23	.	.	.
cord-275433-58unu79x	177	1	Recent	recent	JJ
cord-275433-58unu79x	177	2	evidence	evidence	NN
cord-275433-58unu79x	177	3	indicates	indicate	VBZ
cord-275433-58unu79x	177	4	that	that	IN
cord-275433-58unu79x	177	5	autophagy	autophagy	NN
cord-275433-58unu79x	177	6	functions	function	NNS
cord-275433-58unu79x	177	7	in	in	IN
cord-275433-58unu79x	177	8	delivering	deliver	VBG
cord-275433-58unu79x	177	9	viral	viral	JJ
cord-275433-58unu79x	177	10	nucleic	nucleic	JJ
cord-275433-58unu79x	177	11	acids	acid	NNS
cord-275433-58unu79x	177	12	to	to	IN
cord-275433-58unu79x	177	13	the	the	DT
cord-275433-58unu79x	177	14	innate	innate	JJ
cord-275433-58unu79x	177	15	immune	immune	JJ
cord-275433-58unu79x	177	16	system	system	NN
cord-275433-58unu79x	177	17	12	12	CD
cord-275433-58unu79x	177	18	.	.	.
cord-275433-58unu79x	178	1	A	a	DT
cord-275433-58unu79x	178	2	subset	subset	NN
cord-275433-58unu79x	178	3	of	of	IN
cord-275433-58unu79x	178	4	receptors	receptor	NNS
cord-275433-58unu79x	178	5	of	of	IN
cord-275433-58unu79x	178	6	the	the	DT
cord-275433-58unu79x	178	7	TLR	TLR	NNP
cord-275433-58unu79x	178	8	family	family	NN
cord-275433-58unu79x	178	9	sense	sense	NN
cord-275433-58unu79x	178	10	viral	viral	JJ
cord-275433-58unu79x	178	11	nucleic	nucleic	JJ
cord-275433-58unu79x	178	12	acids	acid	NNS
cord-275433-58unu79x	178	13	in	in	IN
cord-275433-58unu79x	178	14	the	the	DT
cord-275433-58unu79x	178	15	lumen	lumen	NN
cord-275433-58unu79x	178	16	of	of	IN
cord-275433-58unu79x	178	17	endosomes	endosome	NNS
cord-275433-58unu79x	178	18	64	64	CD
cord-275433-58unu79x	178	19	.	.	.
cord-275433-58unu79x	179	1	However	however	RB
cord-275433-58unu79x	179	2	,	,	,
cord-275433-58unu79x	179	3	viral	viral	JJ
cord-275433-58unu79x	179	4	nucleic	nucleic	JJ
cord-275433-58unu79x	179	5	acids	acid	NNS
cord-275433-58unu79x	179	6	are	be	VBP
cord-275433-58unu79x	179	7	most	most	RBS
cord-275433-58unu79x	179	8	often	often	RB
cord-275433-58unu79x	179	9	released	release	VBN
cord-275433-58unu79x	179	10	directly	directly	RB
cord-275433-58unu79x	179	11	into	into	IN
cord-275433-58unu79x	179	12	the	the	DT
cord-275433-58unu79x	179	13	cytoplasm	cytoplasm	NN
cord-275433-58unu79x	179	14	after	after	IN
cord-275433-58unu79x	179	15	fusion	fusion	NN
cord-275433-58unu79x	179	16	of	of	IN
cord-275433-58unu79x	179	17	a	a	DT
cord-275433-58unu79x	179	18	viral	viral	JJ
cord-275433-58unu79x	179	19	envelope	envelope	NN
cord-275433-58unu79x	179	20	with	with	IN
cord-275433-58unu79x	179	21	the	the	DT
cord-275433-58unu79x	179	22	endosomal	endosomal	NNP
cord-275433-58unu79x	179	23	membrane	membrane	NN
cord-275433-58unu79x	179	24	or	or	CC
cord-275433-58unu79x	179	25	penetration	penetration	NN
cord-275433-58unu79x	179	26	of	of	IN
cord-275433-58unu79x	179	27	cellular	cellular	JJ
cord-275433-58unu79x	179	28	membranes	membrane	NNS
cord-275433-58unu79x	179	29	by	by	IN
cord-275433-58unu79x	179	30	a	a	DT
cord-275433-58unu79x	179	31	viral	viral	JJ
cord-275433-58unu79x	179	32	capsid	capsid	NN
cord-275433-58unu79x	179	33	.	.	.
cord-275433-58unu79x	180	1	This	this	DT
cord-275433-58unu79x	180	2	poses	pose	VBZ
cord-275433-58unu79x	180	3	a	a	DT
cord-275433-58unu79x	180	4	topological	topological	JJ
cord-275433-58unu79x	180	5	challenge	challenge	NN
cord-275433-58unu79x	180	6	for	for	IN
cord-275433-58unu79x	180	7	the	the	DT
cord-275433-58unu79x	180	8	efficient	efficient	JJ
cord-275433-58unu79x	180	9	detection	detection	NN
cord-275433-58unu79x	180	10	of	of	IN
cord-275433-58unu79x	180	11	viral	viral	JJ
cord-275433-58unu79x	180	12	nucleic	nucleic	JJ
cord-275433-58unu79x	180	13	acids	acid	NNS
cord-275433-58unu79x	180	14	by	by	IN
cord-275433-58unu79x	180	15	endosomal	endosomal	NNP
cord-275433-58unu79x	180	16	TLRs	TLRs	NNP
cord-275433-58unu79x	180	17	.	.	.
cord-275433-58unu79x	181	1	This	this	DT
cord-275433-58unu79x	181	2	challenge	challenge	NN
cord-275433-58unu79x	181	3	may	may	MD
cord-275433-58unu79x	181	4	be	be	VB
cord-275433-58unu79x	181	5	met	meet	VBN
cord-275433-58unu79x	181	6	,	,	,
cord-275433-58unu79x	181	7	at	at	IN
cord-275433-58unu79x	181	8	least	least	JJS
cord-275433-58unu79x	181	9	in	in	IN
cord-275433-58unu79x	181	10	part	part	NN
cord-275433-58unu79x	181	11	,	,	,
cord-275433-58unu79x	181	12	by	by	IN
cord-275433-58unu79x	181	13	using	use	VBG
cord-275433-58unu79x	181	14	the	the	DT
cord-275433-58unu79x	181	15	autophagic	autophagic	JJ
cord-275433-58unu79x	181	16	pathway	pathway	NN
cord-275433-58unu79x	181	17	for	for	IN
cord-275433-58unu79x	181	18	the	the	DT
cord-275433-58unu79x	181	19	delivery	delivery	NN
cord-275433-58unu79x	181	20	of	of	IN
cord-275433-58unu79x	181	21	cytoplasmic	cytoplasmic	JJ
cord-275433-58unu79x	181	22	viral	viral	JJ
cord-275433-58unu79x	181	23	nucleic	nucleic	JJ
cord-275433-58unu79x	181	24	acids	acid	NNS
cord-275433-58unu79x	181	25	to	to	IN
cord-275433-58unu79x	181	26	endosomal	endosomal	NNP
cord-275433-58unu79x	181	27	TLRs	TLRs	NNP
cord-275433-58unu79x	181	28	,	,	,
cord-275433-58unu79x	181	29	which	which	WDT
cord-275433-58unu79x	181	30	would	would	MD
cord-275433-58unu79x	181	31	then	then	RB
cord-275433-58unu79x	181	32	lead	lead	VB
cord-275433-58unu79x	181	33	to	to	IN
cord-275433-58unu79x	181	34	the	the	DT
cord-275433-58unu79x	181	35	induction	induction	NN
cord-275433-58unu79x	181	36	of	of	IN
cord-275433-58unu79x	181	37	type	type	NN
cord-275433-58unu79x	181	38	-	-	:
cord-275433-58unu79x	181	39	I	i	NN
cord-275433-58unu79x	181	40	-	-	HYPH
cord-275433-58unu79x	181	41	IFN	IFN	NNP
cord-275433-58unu79x	181	42	-	-	HYPH
cord-275433-58unu79x	181	43	dependent	dependent	JJ
cord-275433-58unu79x	181	44	innate	innate	JJ
cord-275433-58unu79x	181	45	immune	immune	JJ
cord-275433-58unu79x	181	46	responses	response	NNS
cord-275433-58unu79x	181	47	(	(	-LRB-
cord-275433-58unu79x	181	48	FIG	fig	NN
cord-275433-58unu79x	181	49	.	.	.
cord-275433-58unu79x	181	50	4	4	LS
cord-275433-58unu79x	181	51	)	)	-RRB-
cord-275433-58unu79x	182	1	So	so	RB
cord-275433-58unu79x	182	2	,	,	,
cord-275433-58unu79x	182	3	similar	similar	JJ
cord-275433-58unu79x	182	4	to	to	IN
cord-275433-58unu79x	182	5	the	the	DT
cord-275433-58unu79x	182	6	use	use	NN
cord-275433-58unu79x	182	7	of	of	IN
cord-275433-58unu79x	182	8	autophagy	autophagy	NN
cord-275433-58unu79x	182	9	for	for	IN
cord-275433-58unu79x	182	10	endogenous	endogenous	JJ
cord-275433-58unu79x	182	11	antigen	antigen	NN
cord-275433-58unu79x	182	12	presentation	presentation	NN
cord-275433-58unu79x	182	13	in	in	IN
cord-275433-58unu79x	182	14	adaptive	adaptive	JJ
cord-275433-58unu79x	182	15	immunity	immunity	NN
cord-275433-58unu79x	182	16	(	(	-LRB-
cord-275433-58unu79x	182	17	described	describe	VBN
cord-275433-58unu79x	182	18	later	later	RB
cord-275433-58unu79x	182	19	)	)	-RRB-
cord-275433-58unu79x	182	20	,	,	,
cord-275433-58unu79x	182	21	autophagy	autophagy	NN
cord-275433-58unu79x	182	22	may	may	MD
cord-275433-58unu79x	182	23	be	be	VB
cord-275433-58unu79x	182	24	used	use	VBN
cord-275433-58unu79x	182	25	for	for	IN
cord-275433-58unu79x	182	26	the	the	DT
cord-275433-58unu79x	182	27	delivery	delivery	NN
cord-275433-58unu79x	182	28	of	of	IN
cord-275433-58unu79x	182	29	endogenous	endogenous	JJ
cord-275433-58unu79x	182	30	viral	viral	JJ
cord-275433-58unu79x	182	31	nucleic	nucleic	JJ
cord-275433-58unu79x	182	32	acids	acid	NNS
cord-275433-58unu79x	182	33	to	to	IN
cord-275433-58unu79x	182	34	their	-PRON-	PRP$
cord-275433-58unu79x	182	35	cognate	cognate	JJ
cord-275433-58unu79x	182	36	innate	innate	JJ
cord-275433-58unu79x	182	37	immunity	immunity	NN
cord-275433-58unu79x	182	38	detectors	detector	NNS
cord-275433-58unu79x	182	39	.	.	.
cord-275433-58unu79x	183	1	The	the	DT
cord-275433-58unu79x	183	2	precise	precise	JJ
cord-275433-58unu79x	183	3	details	detail	NNS
cord-275433-58unu79x	183	4	of	of	IN
cord-275433-58unu79x	183	5	how	how	WRB
cord-275433-58unu79x	183	6	the	the	DT
cord-275433-58unu79x	183	7	autophagy	autophagy	NN
cord-275433-58unu79x	183	8	machinery	machinery	NN
cord-275433-58unu79x	183	9	senses	sense	VBZ
cord-275433-58unu79x	183	10	viral	viral	JJ
cord-275433-58unu79x	183	11	RNA	RNA	NNP
cord-275433-58unu79x	183	12	and	and	CC
cord-275433-58unu79x	183	13	targets	target	VBZ
cord-275433-58unu79x	183	14	it	-PRON-	PRP
cord-275433-58unu79x	183	15	to	to	IN
cord-275433-58unu79x	183	16	endosomal	endosomal	NNP
cord-275433-58unu79x	183	17	TLR7	TLR7	NNP
cord-275433-58unu79x	183	18	remain	remain	VBP
cord-275433-58unu79x	183	19	to	to	TO
cord-275433-58unu79x	183	20	be	be	VB
cord-275433-58unu79x	183	21	elucidated	elucidate	VBN
cord-275433-58unu79x	183	22	.	.	.
cord-275433-58unu79x	184	1	Moreover	moreover	RB
cord-275433-58unu79x	184	2	,	,	,
cord-275433-58unu79x	184	3	it	-PRON-	PRP
cord-275433-58unu79x	184	4	is	be	VBZ
cord-275433-58unu79x	184	5	still	still	RB
cord-275433-58unu79x	184	6	unclear	unclear	JJ
cord-275433-58unu79x	184	7	how	how	WRB
cord-275433-58unu79x	184	8	the	the	DT
cord-275433-58unu79x	184	9	nucleic	nucleic	JJ
cord-275433-58unu79x	184	10	acids	acid	NNS
cord-275433-58unu79x	184	11	of	of	IN
cord-275433-58unu79x	184	12	DNA	dna	NN
cord-275433-58unu79x	184	13	viruses	virus	NNS
cord-275433-58unu79x	184	14	,	,	,
cord-275433-58unu79x	184	15	and	and	CC
cord-275433-58unu79x	184	16	even	even	RB
cord-275433-58unu79x	184	17	other	other	JJ
cord-275433-58unu79x	184	18	RNA	RNA	NNP
cord-275433-58unu79x	184	19	viruses	virus	NNS
cord-275433-58unu79x	184	20	,	,	,
cord-275433-58unu79x	184	21	are	be	VBP
cord-275433-58unu79x	184	22	targeted	target	VBN
cord-275433-58unu79x	184	23	to	to	IN
cord-275433-58unu79x	184	24	endosomal	endosomal	NNP
cord-275433-58unu79x	184	25	TLRs	TLRs	NNP
cord-275433-58unu79x	184	26	in	in	IN
cord-275433-58unu79x	184	27	plasmacytoid	plasmacytoid	NNP
cord-275433-58unu79x	184	28	dendritic	dendritic	JJ
cord-275433-58unu79x	184	29	cells	cell	NNS
cord-275433-58unu79x	184	30	,	,	,
cord-275433-58unu79x	184	31	as	as	IN
cord-275433-58unu79x	184	32	viral	viral	JJ
cord-275433-58unu79x	184	33	replication	replication	NN
cord-275433-58unu79x	184	34	is	be	VBZ
cord-275433-58unu79x	184	35	not	not	RB
cord-275433-58unu79x	184	36	required	require	VBN
cord-275433-58unu79x	184	37	for	for	IN
cord-275433-58unu79x	184	38	type	type	NN
cord-275433-58unu79x	184	39	I	-PRON-	PRP
cord-275433-58unu79x	184	40	IFN	IFN	NNP
cord-275433-58unu79x	184	41	production	production	NN
cord-275433-58unu79x	184	42	in	in	IN
cord-275433-58unu79x	184	43	plasmacytoid	plasmacytoid	NNP
cord-275433-58unu79x	184	44	dendritic	dendritic	JJ
cord-275433-58unu79x	184	45	cells	cell	NNS
cord-275433-58unu79x	184	46	infected	infect	VBN
cord-275433-58unu79x	184	47	with	with	IN
cord-275433-58unu79x	184	48	herpesviruses	herpesviruses	FW
cord-275433-58unu79x	184	49	(	(	-LRB-
cord-275433-58unu79x	184	50	DNA	dna	NN
cord-275433-58unu79x	184	51	viruses	virus	NNS
cord-275433-58unu79x	184	52	)	)	-RRB-
cord-275433-58unu79x	184	53	or	or	CC
cord-275433-58unu79x	184	54	influenza	influenza	NN
cord-275433-58unu79x	184	55	virus	virus	NN
cord-275433-58unu79x	184	56	(	(	-LRB-
cord-275433-58unu79x	184	57	an	an	DT
cord-275433-58unu79x	184	58	RNA	RNA	NNP
cord-275433-58unu79x	184	59	virus	virus	NN
cord-275433-58unu79x	184	60	)	)	-RRB-
cord-275433-58unu79x	185	1	12	12	CD
cord-275433-58unu79x	185	2	,	,	,
cord-275433-58unu79x	185	3	65	65	CD
cord-275433-58unu79x	185	4	.	.	.
cord-275433-58unu79x	186	1	Another	another	DT
cord-275433-58unu79x	186	2	unexplored	unexplored	JJ
cord-275433-58unu79x	186	3	question	question	NN
cord-275433-58unu79x	186	4	is	be	VBZ
cord-275433-58unu79x	186	5	whether	whether	IN
cord-275433-58unu79x	186	6	there	there	EX
cord-275433-58unu79x	186	7	is	be	VBZ
cord-275433-58unu79x	186	8	any	any	DT
cord-275433-58unu79x	186	9	molecular	molecular	JJ
cord-275433-58unu79x	186	10	interplay	interplay	NN
cord-275433-58unu79x	186	11	between	between	IN
cord-275433-58unu79x	186	12	the	the	DT
cord-275433-58unu79x	186	13	autophagy	autophagy	NN
cord-275433-58unu79x	186	14	pathway	pathway	NN
cord-275433-58unu79x	186	15	and	and	CC
cord-275433-58unu79x	186	16	type	type	NN
cord-275433-58unu79x	187	1	I	-PRON-	PRP
cord-275433-58unu79x	187	2	IFN	IFN	NNP
cord-275433-58unu79x	187	3	signalling	signal	VBG
cord-275433-58unu79x	187	4	mediated	mediate	VBN
cord-275433-58unu79x	187	5	by	by	IN
cord-275433-58unu79x	187	6	cytoplasmic	cytoplasmic	JJ
cord-275433-58unu79x	187	7	RNA	RNA	NNP
cord-275433-58unu79x	187	8	helicases	helicase	NNS
cord-275433-58unu79x	187	9	that	that	WDT
cord-275433-58unu79x	187	10	function	function	VBP
cord-275433-58unu79x	187	11	as	as	IN
cord-275433-58unu79x	187	12	receptors	receptor	NNS
cord-275433-58unu79x	187	13	for	for	IN
cord-275433-58unu79x	187	14	cytoplasmic	cytoplasmic	JJ
cord-275433-58unu79x	187	15	double	double	RB
cord-275433-58unu79x	187	16	-	-	HYPH
cord-275433-58unu79x	187	17	stranded	strand	VBN
cord-275433-58unu79x	187	18	RNA	RNA	NNP
cord-275433-58unu79x	187	19	produced	produce	VBN
cord-275433-58unu79x	187	20	during	during	IN
cord-275433-58unu79x	187	21	viral	viral	JJ
cord-275433-58unu79x	187	22	infection	infection	NN
cord-275433-58unu79x	187	23	.	.	.
cord-275433-58unu79x	188	1	The	the	DT
cord-275433-58unu79x	188	2	role	role	NN
cord-275433-58unu79x	188	3	of	of	IN
cord-275433-58unu79x	188	4	autophagy	autophagy	NN
cord-275433-58unu79x	188	5	in	in	IN
cord-275433-58unu79x	188	6	immunity	immunity	NN
cord-275433-58unu79x	188	7	is	be	VBZ
cord-275433-58unu79x	188	8	not	not	RB
cord-275433-58unu79x	188	9	limited	limit	VBN
cord-275433-58unu79x	188	10	to	to	IN
cord-275433-58unu79x	188	11	the	the	DT
cord-275433-58unu79x	188	12	direct	direct	JJ
cord-275433-58unu79x	188	13	elimination	elimination	NN
cord-275433-58unu79x	188	14	of	of	IN
cord-275433-58unu79x	188	15	intracellular	intracellular	JJ
cord-275433-58unu79x	188	16	pathogens	pathogen	NNS
cord-275433-58unu79x	188	17	or	or	CC
cord-275433-58unu79x	188	18	stimulation	stimulation	NN
cord-275433-58unu79x	188	19	of	of	IN
cord-275433-58unu79x	188	20	type	type	NN
cord-275433-58unu79x	188	21	I	-PRON-	PRP
cord-275433-58unu79x	188	22	IFN	IFN	NNP
cord-275433-58unu79x	188	23	production	production	NN
cord-275433-58unu79x	188	24	.	.	.
cord-275433-58unu79x	189	1	At	at	IN
cord-275433-58unu79x	189	2	least	least	JJS
cord-275433-58unu79x	189	3	in	in	IN
cord-275433-58unu79x	189	4	certain	certain	JJ
cord-275433-58unu79x	189	5	contexts	context	NNS
cord-275433-58unu79x	189	6	,	,	,
cord-275433-58unu79x	189	7	autophagy	autophagy	NN
cord-275433-58unu79x	189	8	promotes	promote	VBZ
cord-275433-58unu79x	189	9	MHC	MHC	NNP
cord-275433-58unu79x	189	10	class	class	NN
cord-275433-58unu79x	189	11	II	II	NNP
cord-275433-58unu79x	189	12	presentation	presentation	NN
cord-275433-58unu79x	189	13	of	of	IN
cord-275433-58unu79x	189	14	cytosolic	cytosolic	JJ
cord-275433-58unu79x	189	15	antigens	antigen	NNS
cord-275433-58unu79x	189	16	[	[	-LRB-
cord-275433-58unu79x	189	17	66	66	CD
cord-275433-58unu79x	189	18	]	]	-RRB-
cord-275433-58unu79x	190	1	[	[	-LRB-
cord-275433-58unu79x	190	2	67	67	CD
cord-275433-58unu79x	190	3	]	]	-RRB-
cord-275433-58unu79x	191	1	[	[	-LRB-
cord-275433-58unu79x	191	2	68	68	CD
cord-275433-58unu79x	191	3	]	]	-RRB-
cord-275433-58unu79x	191	4	[	[	-LRB-
cord-275433-58unu79x	191	5	69	69	CD
cord-275433-58unu79x	191	6	]	]	-RRB-
cord-275433-58unu79x	191	7	[	[	-LRB-
cord-275433-58unu79x	191	8	70	70	CD
cord-275433-58unu79x	191	9	]	]	-RRB-
cord-275433-58unu79x	191	10	70	70	CD
cord-275433-58unu79x	191	11	.	.	.
cord-275433-58unu79x	192	1	Together	together	RB
cord-275433-58unu79x	192	2	,	,	,
cord-275433-58unu79x	192	3	these	these	DT
cord-275433-58unu79x	192	4	initial	initial	JJ
cord-275433-58unu79x	192	5	studies	study	NNS
cord-275433-58unu79x	192	6	led	lead	VBD
cord-275433-58unu79x	192	7	to	to	IN
cord-275433-58unu79x	192	8	the	the	DT
cord-275433-58unu79x	192	9	generally	generally	RB
cord-275433-58unu79x	192	10	accepted	accept	VBN
cord-275433-58unu79x	192	11	idea	idea	NN
cord-275433-58unu79x	192	12	that	that	IN
cord-275433-58unu79x	192	13	the	the	DT
cord-275433-58unu79x	192	14	autophagy	autophagy	NN
cord-275433-58unu79x	192	15	pathway	pathway	NN
cord-275433-58unu79x	192	16	allows	allow	VBZ
cord-275433-58unu79x	192	17	the	the	DT
cord-275433-58unu79x	192	18	transfer	transfer	NN
cord-275433-58unu79x	192	19	of	of	IN
cord-275433-58unu79x	192	20	cytosolic	cytosolic	JJ
cord-275433-58unu79x	192	21	antigens	antigen	NNS
cord-275433-58unu79x	192	22	to	to	IN
cord-275433-58unu79x	192	23	late	late	JJ
cord-275433-58unu79x	192	24	endosomal	endosomal	NNP
cord-275433-58unu79x	192	25	or	or	CC
cord-275433-58unu79x	192	26	lysosomal	lysosomal	JJ
cord-275433-58unu79x	192	27	compartments	compartment	NNS
cord-275433-58unu79x	192	28	(	(	-LRB-
cord-275433-58unu79x	192	29	FIG	fig	NN
cord-275433-58unu79x	192	30	.	.	.
cord-275433-58unu79x	192	31	4	4	LS
cord-275433-58unu79x	192	32	)	)	-RRB-
cord-275433-58unu79x	192	33	,	,	,
cord-275433-58unu79x	192	34	in	in	IN
cord-275433-58unu79x	192	35	contrast	contrast	NN
cord-275433-58unu79x	192	36	to	to	IN
cord-275433-58unu79x	192	37	the	the	DT
cord-275433-58unu79x	192	38	processing	processing	NN
cord-275433-58unu79x	192	39	of	of	IN
cord-275433-58unu79x	192	40	exogenous	exogenous	JJ
cord-275433-58unu79x	192	41	antigens	antigen	NNS
cord-275433-58unu79x	192	42	captured	capture	VBN
cord-275433-58unu79x	192	43	through	through	IN
cord-275433-58unu79x	192	44	endocytosis	endocytosis	NN
cord-275433-58unu79x	192	45	or	or	CC
cord-275433-58unu79x	192	46	phagocytosis	phagocytosis	NN
cord-275433-58unu79x	192	47	in	in	IN
cord-275433-58unu79x	192	48	antigen	antigen	NN
cord-275433-58unu79x	192	49	-	-	HYPH
cord-275433-58unu79x	192	50	presenting	present	VBG
cord-275433-58unu79x	192	51	cells	cell	NNS
cord-275433-58unu79x	192	52	.	.	.
cord-275433-58unu79x	193	1	The	the	DT
cord-275433-58unu79x	193	2	autophagic	autophagic	JJ
cord-275433-58unu79x	193	3	delivery	delivery	NN
cord-275433-58unu79x	193	4	of	of	IN
cord-275433-58unu79x	193	5	cytosolic	cytosolic	JJ
cord-275433-58unu79x	193	6	antigens	antigen	NNS
cord-275433-58unu79x	193	7	to	to	IN
cord-275433-58unu79x	193	8	endosomes	endosome	NNS
cord-275433-58unu79x	193	9	and/or	and/or	CC
cord-275433-58unu79x	193	10	lysosomes	lysosome	NNS
cord-275433-58unu79x	193	11	represents	represent	VBZ
cord-275433-58unu79x	193	12	an	an	DT
cord-275433-58unu79x	193	13	attractive	attractive	JJ
cord-275433-58unu79x	193	14	model	model	NN
cord-275433-58unu79x	193	15	for	for	IN
cord-275433-58unu79x	193	16	explaining	explain	VBG
cord-275433-58unu79x	193	17	why	why	WRB
cord-275433-58unu79x	193	18	the	the	DT
cord-275433-58unu79x	193	19	MHC	MHC	NNP
cord-275433-58unu79x	193	20	class	class	NN
cord-275433-58unu79x	193	21	II	II	NNP
cord-275433-58unu79x	193	22	peptidome	peptidome	NN
cord-275433-58unu79x	193	23	contains	contain	VBZ
cord-275433-58unu79x	193	24	many	many	JJ
cord-275433-58unu79x	193	25	peptides	peptide	NNS
cord-275433-58unu79x	193	26	of	of	IN
cord-275433-58unu79x	193	27	cytosolic	cytosolic	JJ
cord-275433-58unu79x	193	28	or	or	CC
cord-275433-58unu79x	193	29	nuclear	nuclear	JJ
cord-275433-58unu79x	193	30	origin	origin	NN
cord-275433-58unu79x	193	31	that	that	WDT
cord-275433-58unu79x	193	32	can	can	MD
cord-275433-58unu79x	193	33	not	not	RB
cord-275433-58unu79x	193	34	be	be	VB
cord-275433-58unu79x	193	35	delivered	deliver	VBN
cord-275433-58unu79x	193	36	to	to	IN
cord-275433-58unu79x	193	37	MHC	MHC	NNP
cord-275433-58unu79x	193	38	class	class	NN
cord-275433-58unu79x	193	39	II	II	NNP
cord-275433-58unu79x	193	40	compartments	compartment	NNS
cord-275433-58unu79x	193	41	by	by	IN
cord-275433-58unu79x	193	42	the	the	DT
cord-275433-58unu79x	193	43	classical	classical	JJ
cord-275433-58unu79x	193	44	exogenous	exogenous	JJ
cord-275433-58unu79x	193	45	route	route	NN
cord-275433-58unu79x	193	46	.	.	.
cord-275433-58unu79x	194	1	However	however	RB
cord-275433-58unu79x	194	2	,	,	,
cord-275433-58unu79x	194	3	it	-PRON-	PRP
cord-275433-58unu79x	194	4	is	be	VBZ
cord-275433-58unu79x	194	5	not	not	RB
cord-275433-58unu79x	194	6	yet	yet	RB
cord-275433-58unu79x	194	7	clear	clear	JJ
cord-275433-58unu79x	194	8	how	how	WRB
cord-275433-58unu79x	194	9	universal	universal	JJ
cord-275433-58unu79x	194	10	a	a	DT
cord-275433-58unu79x	194	11	role	role	NN
cord-275433-58unu79x	194	12	autophagy	autophagy	NN
cord-275433-58unu79x	194	13	has	have	VBZ
cord-275433-58unu79x	194	14	in	in	IN
cord-275433-58unu79x	194	15	the	the	DT
cord-275433-58unu79x	194	16	delivery	delivery	NN
cord-275433-58unu79x	194	17	of	of	IN
cord-275433-58unu79x	194	18	self	self	NN
cord-275433-58unu79x	194	19	and	and	CC
cord-275433-58unu79x	194	20	foreign	foreign	JJ
cord-275433-58unu79x	194	21	cytosolic	cytosolic	JJ
cord-275433-58unu79x	194	22	and	and	CC
cord-275433-58unu79x	194	23	nuclear	nuclear	JJ
cord-275433-58unu79x	194	24	antigens	antigen	NNS
cord-275433-58unu79x	194	25	.	.	.
cord-275433-58unu79x	195	1	Interestingly	interestingly	RB
cord-275433-58unu79x	195	2	,	,	,
cord-275433-58unu79x	195	3	high	high	JJ
cord-275433-58unu79x	195	4	levels	level	NNS
cord-275433-58unu79x	195	5	of	of	IN
cord-275433-58unu79x	195	6	autophagy	autophagy	NN
cord-275433-58unu79x	195	7	activity	activity	NN
cord-275433-58unu79x	195	8	are	be	VBP
cord-275433-58unu79x	195	9	observed	observe	VBN
cord-275433-58unu79x	195	10	in	in	IN
cord-275433-58unu79x	195	11	the	the	DT
cord-275433-58unu79x	195	12	thymic	thymic	JJ
cord-275433-58unu79x	195	13	epithelial	epithelial	JJ
cord-275433-58unu79x	195	14	cells	cell	NNS
cord-275433-58unu79x	195	15	of	of	IN
cord-275433-58unu79x	195	16	newborn	newborn	JJ
cord-275433-58unu79x	195	17	mice	mouse	NNS
cord-275433-58unu79x	195	18	that	that	WDT
cord-275433-58unu79x	195	19	transgenically	transgenically	RB
cord-275433-58unu79x	195	20	express	express	VBP
cord-275433-58unu79x	195	21	a	a	DT
cord-275433-58unu79x	195	22	fluorescently	fluorescently	RB
cord-275433-58unu79x	195	23	tagged	tag	VBN
cord-275433-58unu79x	195	24	autophagy	autophagy	NN
cord-275433-58unu79x	195	25	marker	marker	NN
cord-275433-58unu79x	195	26	(	(	-LRB-
cord-275433-58unu79x	195	27	green	green	JJ
cord-275433-58unu79x	195	28	fluorescent	fluorescent	NN
cord-275433-58unu79x	195	29	protein	protein	NN
cord-275433-58unu79x	195	30	(	(	-LRB-
cord-275433-58unu79x	195	31	GFP)-LC3	gfp)-lc3	JJ
cord-275433-58unu79x	195	32	)	)	-RRB-
cord-275433-58unu79x	195	33	71	71	CD
cord-275433-58unu79x	195	34	,	,	,
cord-275433-58unu79x	195	35	suggesting	suggest	VBG
cord-275433-58unu79x	195	36	that	that	IN
cord-275433-58unu79x	195	37	autophagy	autophagy	NN
cord-275433-58unu79x	195	38	may	may	MD
cord-275433-58unu79x	195	39	indeed	indeed	RB
cord-275433-58unu79x	195	40	enable	enable	VB
cord-275433-58unu79x	195	41	thymic	thymic	JJ
cord-275433-58unu79x	195	42	epithelial	epithelial	JJ
cord-275433-58unu79x	195	43	cells	cell	NNS
cord-275433-58unu79x	195	44	to	to	TO
cord-275433-58unu79x	195	45	present	present	VB
cord-275433-58unu79x	195	46	self	self	NN
cord-275433-58unu79x	195	47	antigens	antigen	NNS
cord-275433-58unu79x	195	48	to	to	IN
cord-275433-58unu79x	195	49	lymphocytes	lymphocyte	NNS
cord-275433-58unu79x	195	50	during	during	IN
cord-275433-58unu79x	195	51	positive	positive	JJ
cord-275433-58unu79x	195	52	and	and	CC
cord-275433-58unu79x	195	53	negative	negative	JJ
cord-275433-58unu79x	195	54	selection	selection	NN
cord-275433-58unu79x	195	55	.	.	.
cord-275433-58unu79x	196	1	Yet	yet	RB
cord-275433-58unu79x	196	2	,	,	,
cord-275433-58unu79x	196	3	the	the	DT
cord-275433-58unu79x	196	4	role	role	NN
cord-275433-58unu79x	196	5	of	of	IN
cord-275433-58unu79x	196	6	autophagy	autophagy	NN
cord-275433-58unu79x	196	7	in	in	IN
cord-275433-58unu79x	196	8	MHC	MHC	NNP
cord-275433-58unu79x	196	9	class	class	NN
cord-275433-58unu79x	196	10	II	II	NNP
cord-275433-58unu79x	196	11	presentation	presentation	NN
cord-275433-58unu79x	196	12	of	of	IN
cord-275433-58unu79x	196	13	self	self	NN
cord-275433-58unu79x	196	14	antigens	antigen	NNS
cord-275433-58unu79x	196	15	has	have	VBZ
cord-275433-58unu79x	196	16	not	not	RB
cord-275433-58unu79x	196	17	yet	yet	RB
cord-275433-58unu79x	196	18	been	be	VBN
cord-275433-58unu79x	196	19	directly	directly	RB
cord-275433-58unu79x	196	20	examined	examine	VBN
cord-275433-58unu79x	196	21	.	.	.
cord-275433-58unu79x	197	1	Moreover	moreover	RB
cord-275433-58unu79x	197	2	,	,	,
cord-275433-58unu79x	197	3	whereas	whereas	IN
cord-275433-58unu79x	197	4	ebNA1	ebNA1	NNP
cord-275433-58unu79x	197	5	is	be	VBZ
cord-275433-58unu79x	197	6	processed	process	VBN
cord-275433-58unu79x	197	7	by	by	IN
cord-275433-58unu79x	197	8	autophagy	autophagy	NN
cord-275433-58unu79x	197	9	,	,	,
cord-275433-58unu79x	197	10	two	two	CD
cord-275433-58unu79x	197	11	other	other	JJ
cord-275433-58unu79x	197	12	epstein	epstein	NNP
cord-275433-58unu79x	197	13	-	-	HYPH
cord-275433-58unu79x	197	14	barr	barr	NNP
cord-275433-58unu79x	197	15	-	-	HYPH
cord-275433-58unu79x	197	16	virusencoded	virusencode	VBN
cord-275433-58unu79x	197	17	nuclear	nuclear	JJ
cord-275433-58unu79x	197	18	antigens	antigen	NNS
cord-275433-58unu79x	197	19	,	,	,
cord-275433-58unu79x	197	20	ebNA2	ebNA2	NNP
cord-275433-58unu79x	197	21	and	and	CC
cord-275433-58unu79x	197	22	ebNA3C	ebNA3C	NNP
cord-275433-58unu79x	197	23	,	,	,
cord-275433-58unu79x	197	24	are	be	VBP
cord-275433-58unu79x	197	25	preferentially	preferentially	RB
cord-275433-58unu79x	197	26	processed	process	VBN
cord-275433-58unu79x	197	27	by	by	IN
cord-275433-58unu79x	197	28	intracellular	intracellular	JJ
cord-275433-58unu79x	197	29	transfer	transfer	NN
cord-275433-58unu79x	197	30	of	of	IN
cord-275433-58unu79x	197	31	antigenic	antigenic	JJ
cord-275433-58unu79x	197	32	moieties	moiety	NNS
cord-275433-58unu79x	197	33	and	and	CC
cord-275433-58unu79x	197	34	endocytic	endocytic	JJ
cord-275433-58unu79x	197	35	uptake	uptake	NN
cord-275433-58unu79x	197	36	from	from	IN
cord-275433-58unu79x	197	37	the	the	DT
cord-275433-58unu79x	197	38	culture	culture	NN
cord-275433-58unu79x	197	39	media	medium	NNS
cord-275433-58unu79x	197	40	72	72	CD
cord-275433-58unu79x	197	41	,	,	,
cord-275433-58unu79x	197	42	indicating	indicate	VBG
cord-275433-58unu79x	197	43	that	that	IN
cord-275433-58unu79x	197	44	autophagy	autophagy	NN
cord-275433-58unu79x	197	45	may	may	MD
cord-275433-58unu79x	197	46	only	only	RB
cord-275433-58unu79x	197	47	be	be	VB
cord-275433-58unu79x	197	48	used	use	VBN
cord-275433-58unu79x	197	49	for	for	IN
cord-275433-58unu79x	197	50	MHC	MHC	NNP
cord-275433-58unu79x	197	51	class	class	NN
cord-275433-58unu79x	197	52	II	II	NNP
cord-275433-58unu79x	197	53	presentation	presentation	NN
cord-275433-58unu79x	197	54	of	of	IN
cord-275433-58unu79x	197	55	certain	certain	JJ
cord-275433-58unu79x	197	56	endogenously	endogenously	RB
cord-275433-58unu79x	197	57	produced	produce	VBN
cord-275433-58unu79x	197	58	viral	viral	JJ
cord-275433-58unu79x	197	59	antigens	antigen	NNS
cord-275433-58unu79x	197	60	.	.	.
cord-275433-58unu79x	198	1	A	a	DT
cord-275433-58unu79x	198	2	fascinating	fascinating	JJ
cord-275433-58unu79x	198	3	question	question	NN
cord-275433-58unu79x	198	4	is	be	VBZ
cord-275433-58unu79x	198	5	why	why	WRB
cord-275433-58unu79x	198	6	,	,	,
cord-275433-58unu79x	198	7	even	even	RB
cord-275433-58unu79x	198	8	in	in	IN
cord-275433-58unu79x	198	9	the	the	DT
cord-275433-58unu79x	198	10	same	same	JJ
cord-275433-58unu79x	198	11	cell	cell	NN
cord-275433-58unu79x	198	12	,	,	,
cord-275433-58unu79x	198	13	some	some	DT
cord-275433-58unu79x	198	14	microbial	microbial	JJ
cord-275433-58unu79x	198	15	antigens	antigen	NNS
cord-275433-58unu79x	198	16	,	,	,
cord-275433-58unu79x	198	17	but	but	CC
cord-275433-58unu79x	198	18	not	not	RB
cord-275433-58unu79x	198	19	others	other	NNS
cord-275433-58unu79x	198	20	,	,	,
cord-275433-58unu79x	198	21	gain	gain	VB
cord-275433-58unu79x	198	22	access	access	NN
cord-275433-58unu79x	198	23	to	to	IN
cord-275433-58unu79x	198	24	the	the	DT
cord-275433-58unu79x	198	25	MHC	MHC	NNP
cord-275433-58unu79x	198	26	class	class	NN
cord-275433-58unu79x	198	27	II	II	NNP
cord-275433-58unu79x	198	28	antigen	antigen	NN
cord-275433-58unu79x	198	29	-	-	HYPH
cord-275433-58unu79x	198	30	presentation	presentation	NN
cord-275433-58unu79x	198	31	pathway	pathway	NN
cord-275433-58unu79x	198	32	by	by	IN
cord-275433-58unu79x	198	33	autophagy	autophagy	NN
cord-275433-58unu79x	198	34	.	.	.
cord-275433-58unu79x	199	1	As	as	IN
cord-275433-58unu79x	199	2	some	some	DT
cord-275433-58unu79x	199	3	of	of	IN
cord-275433-58unu79x	199	4	the	the	DT
cord-275433-58unu79x	199	5	earlier	early	JJR
cord-275433-58unu79x	199	6	studies	study	NNS
cord-275433-58unu79x	199	7	that	that	WDT
cord-275433-58unu79x	199	8	showed	show	VBD
cord-275433-58unu79x	199	9	a	a	DT
cord-275433-58unu79x	199	10	role	role	NN
cord-275433-58unu79x	199	11	for	for	IN
cord-275433-58unu79x	199	12	autophagy	autophagy	NN
cord-275433-58unu79x	199	13	in	in	IN
cord-275433-58unu79x	199	14	MHC	MHC	NNP
cord-275433-58unu79x	199	15	class	class	NN
cord-275433-58unu79x	199	16	II	II	NNP
cord-275433-58unu79x	199	17	presentation	presentation	NN
cord-275433-58unu79x	199	18	of	of	IN
cord-275433-58unu79x	199	19	endogenous	endogenous	JJ
cord-275433-58unu79x	199	20	antigens	antigen	NNS
cord-275433-58unu79x	199	21	were	be	VBD
cord-275433-58unu79x	199	22	performed	perform	VBN
cord-275433-58unu79x	199	23	in	in	IN
cord-275433-58unu79x	199	24	conditions	condition	NNS
cord-275433-58unu79x	199	25	in	in	IN
cord-275433-58unu79x	199	26	which	which	WDT
cord-275433-58unu79x	199	27	autophagy	autophagy	NN
cord-275433-58unu79x	199	28	was	be	VBD
cord-275433-58unu79x	199	29	upregulated	upregulate	VBN
cord-275433-58unu79x	199	30	by	by	IN
cord-275433-58unu79x	199	31	cell	cell	NN
cord-275433-58unu79x	199	32	starvation	starvation	NN
cord-275433-58unu79x	199	33	,	,	,
cord-275433-58unu79x	199	34	another	another	DT
cord-275433-58unu79x	199	35	important	important	JJ
cord-275433-58unu79x	199	36	question	question	NN
cord-275433-58unu79x	199	37	has	have	VBZ
cord-275433-58unu79x	199	38	been	be	VBN
cord-275433-58unu79x	199	39	whether	whether	IN
cord-275433-58unu79x	199	40	cytosolic	cytosolic	JJ
cord-275433-58unu79x	199	41	antigens	antigen	NNS
cord-275433-58unu79x	199	42	are	be	VBP
cord-275433-58unu79x	199	43	delivered	deliver	VBN
cord-275433-58unu79x	199	44	to	to	IN
cord-275433-58unu79x	199	45	MHC	MHC	NNP
cord-275433-58unu79x	199	46	class	class	NN
cord-275433-58unu79x	199	47	II	II	NNP
cord-275433-58unu79x	199	48	molecules	molecule	NNS
cord-275433-58unu79x	199	49	by	by	IN
cord-275433-58unu79x	199	50	autophagy	autophagy	NN
cord-275433-58unu79x	199	51	under	under	IN
cord-275433-58unu79x	199	52	normal	normal	JJ
cord-275433-58unu79x	199	53	conditions	condition	NNS
cord-275433-58unu79x	199	54	.	.	.
cord-275433-58unu79x	200	1	Recently	recently	RB
cord-275433-58unu79x	200	2	,	,	,
cord-275433-58unu79x	200	3	Figure	Figure	NNP
cord-275433-58unu79x	200	4	4	4	CD
cord-275433-58unu79x	200	5	|	|	NNP
cord-275433-58unu79x	200	6	Functions	function	NNS
cord-275433-58unu79x	200	7	of	of	IN
cord-275433-58unu79x	200	8	autophagy	autophagy	NN
cord-275433-58unu79x	200	9	in	in	IN
cord-275433-58unu79x	200	10	innate	innate	JJ
cord-275433-58unu79x	200	11	and	and	CC
cord-275433-58unu79x	200	12	adaptive	adaptive	JJ
cord-275433-58unu79x	200	13	immunity	immunity	NN
cord-275433-58unu79x	200	14	during	during	IN
cord-275433-58unu79x	200	15	infection	infection	NN
cord-275433-58unu79x	200	16	with	with	IN
cord-275433-58unu79x	200	17	intracellular	intracellular	JJ
cord-275433-58unu79x	200	18	pathogens	pathogen	NNS
cord-275433-58unu79x	200	19	.	.	.
cord-275433-58unu79x	201	1	a	a	DT
cord-275433-58unu79x	201	2	|	|	CD
cord-275433-58unu79x	202	1	Intracellular	Intracellular	NNP
cord-275433-58unu79x	202	2	pathogens	pathogen	NNS
cord-275433-58unu79x	202	3	(	(	-LRB-
cord-275433-58unu79x	202	4	bacteria	bacteria	NNS
cord-275433-58unu79x	202	5	,	,	,
cord-275433-58unu79x	202	6	parasites	parasite	NNS
cord-275433-58unu79x	202	7	and	and	CC
cord-275433-58unu79x	202	8	viruses	virus	NNS
cord-275433-58unu79x	202	9	)	)	-RRB-
cord-275433-58unu79x	203	1	that	that	WDT
cord-275433-58unu79x	203	2	are	be	VBP
cord-275433-58unu79x	203	3	either	either	CC
cord-275433-58unu79x	203	4	free	free	JJ
cord-275433-58unu79x	203	5	inside	inside	IN
cord-275433-58unu79x	203	6	the	the	DT
cord-275433-58unu79x	203	7	cytosol	cytosol	NN
cord-275433-58unu79x	203	8	,	,	,
cord-275433-58unu79x	203	9	inside	inside	IN
cord-275433-58unu79x	203	10	phagosomes	phagosome	NNS
cord-275433-58unu79x	203	11	or	or	CC
cord-275433-58unu79x	203	12	inside	inside	JJ
cord-275433-58unu79x	203	13	pathogen	pathogen	NN
cord-275433-58unu79x	203	14	-	-	HYPH
cord-275433-58unu79x	203	15	containing	contain	VBG
cord-275433-58unu79x	203	16	vacuoles	vacuole	NNS
cord-275433-58unu79x	203	17	are	be	VBP
cord-275433-58unu79x	203	18	surrounded	surround	VBN
cord-275433-58unu79x	203	19	by	by	IN
cord-275433-58unu79x	203	20	isolation	isolation	NN
cord-275433-58unu79x	203	21	membranes	membrane	NNS
cord-275433-58unu79x	203	22	,	,	,
cord-275433-58unu79x	203	23	engulfed	engulf	VBN
cord-275433-58unu79x	203	24	into	into	IN
cord-275433-58unu79x	203	25	autophagosomes	autophagosomes	NNP
cord-275433-58unu79x	203	26	,	,	,
cord-275433-58unu79x	203	27	which	which	WDT
cord-275433-58unu79x	203	28	fuse	fuse	VBP
cord-275433-58unu79x	203	29	with	with	IN
cord-275433-58unu79x	203	30	lysosomes	lysosome	NNS
cord-275433-58unu79x	203	31	,	,	,
cord-275433-58unu79x	203	32	and	and	CC
cord-275433-58unu79x	203	33	then	then	RB
cord-275433-58unu79x	203	34	degraded	degrade	VBD
cord-275433-58unu79x	203	35	inside	inside	IN
cord-275433-58unu79x	203	36	autolysosomes	autolysosome	NNS
cord-275433-58unu79x	203	37	.	.	.
cord-275433-58unu79x	204	1	b	b	LS
cord-275433-58unu79x	204	2	|	|	NNP
cord-275433-58unu79x	204	3	Viral	Viral	NNP
cord-275433-58unu79x	204	4	nucleic	nucleic	JJ
cord-275433-58unu79x	204	5	acids	acid	NNS
cord-275433-58unu79x	204	6	are	be	VBP
cord-275433-58unu79x	204	7	transferred	transfer	VBN
cord-275433-58unu79x	204	8	by	by	IN
cord-275433-58unu79x	204	9	autophagy	autophagy	NN
cord-275433-58unu79x	204	10	from	from	IN
cord-275433-58unu79x	204	11	the	the	DT
cord-275433-58unu79x	204	12	cytoplasm	cytoplasm	NN
cord-275433-58unu79x	204	13	to	to	IN
cord-275433-58unu79x	204	14	intracellular	intracellular	JJ
cord-275433-58unu79x	204	15	compartments	compartment	NNS
cord-275433-58unu79x	204	16	containing	contain	VBG
cord-275433-58unu79x	204	17	Toll	Toll	NNP
cord-275433-58unu79x	204	18	-	-	HYPH
cord-275433-58unu79x	204	19	like	like	JJ
cord-275433-58unu79x	204	20	receptor	receptor	NN
cord-275433-58unu79x	204	21	7	7	CD
cord-275433-58unu79x	204	22	(	(	-LRB-
cord-275433-58unu79x	204	23	TLR7	TLR7	NNP
cord-275433-58unu79x	204	24	)	)	-RRB-
cord-275433-58unu79x	204	25	,	,	,
cord-275433-58unu79x	204	26	which	which	WDT
cord-275433-58unu79x	204	27	signals	signal	VBZ
cord-275433-58unu79x	204	28	the	the	DT
cord-275433-58unu79x	204	29	induction	induction	NN
cord-275433-58unu79x	204	30	of	of	IN
cord-275433-58unu79x	204	31	type	type	NN
cord-275433-58unu79x	205	1	I	-PRON-	PRP
cord-275433-58unu79x	206	1	interferon	interferon	NNP
cord-275433-58unu79x	206	2	(	(	-LRB-
cord-275433-58unu79x	206	3	IFN	IFN	NNP
cord-275433-58unu79x	206	4	)	)	-RRB-
cord-275433-58unu79x	206	5	production	production	NN
cord-275433-58unu79x	206	6	.	.	.
cord-275433-58unu79x	207	1	c	c	NNP
cord-275433-58unu79x	207	2	|	|	:
cord-275433-58unu79x	207	3	Viral	viral	JJ
cord-275433-58unu79x	207	4	antigens	antigen	NNS
cord-275433-58unu79x	207	5	(	(	-LRB-
cord-275433-58unu79x	207	6	and	and	CC
cord-275433-58unu79x	207	7	potentially	potentially	RB
cord-275433-58unu79x	207	8	other	other	JJ
cord-275433-58unu79x	207	9	endogenously	endogenously	RB
cord-275433-58unu79x	207	10	synthesized	synthesize	VBN
cord-275433-58unu79x	207	11	microbial	microbial	JJ
cord-275433-58unu79x	207	12	antigens	antigen	NNS
cord-275433-58unu79x	207	13	and	and	CC
cord-275433-58unu79x	207	14	self	self	NN
cord-275433-58unu79x	207	15	antigens	antigen	NNS
cord-275433-58unu79x	207	16	)	)	-RRB-
cord-275433-58unu79x	207	17	are	be	VBP
cord-275433-58unu79x	207	18	engulfed	engulf	VBN
cord-275433-58unu79x	207	19	into	into	IN
cord-275433-58unu79x	207	20	autophagosomes	autophagosome	NNS
cord-275433-58unu79x	207	21	that	that	WDT
cord-275433-58unu79x	207	22	fuse	fuse	NN
cord-275433-58unu79x	207	23	with	with	IN
cord-275433-58unu79x	207	24	MHC	MHC	NNP
cord-275433-58unu79x	207	25	-	-	HYPH
cord-275433-58unu79x	207	26	class	class	NN
cord-275433-58unu79x	207	27	-	-	HYPH
cord-275433-58unu79x	207	28	II	ii	NN
cord-275433-58unu79x	207	29	-	-	HYPH
cord-275433-58unu79x	207	30	containing	contain	VBG
cord-275433-58unu79x	207	31	late	late	JJ
cord-275433-58unu79x	207	32	endosomes	endosome	NNS
cord-275433-58unu79x	207	33	(	(	-LRB-
cord-275433-58unu79x	207	34	MIICs	MIICs	NNP
cord-275433-58unu79x	207	35	)	)	-RRB-
cord-275433-58unu79x	207	36	,	,	,
cord-275433-58unu79x	207	37	and	and	CC
cord-275433-58unu79x	207	38	then	then	RB
cord-275433-58unu79x	207	39	loaded	load	VBD
cord-275433-58unu79x	207	40	onto	onto	IN
cord-275433-58unu79x	207	41	MHC	MHC	NNP
cord-275433-58unu79x	207	42	class	class	NN
cord-275433-58unu79x	207	43	II	II	NNP
cord-275433-58unu79x	207	44	molecules	molecule	NNS
cord-275433-58unu79x	207	45	for	for	IN
cord-275433-58unu79x	207	46	presentation	presentation	NN
cord-275433-58unu79x	207	47	to	to	IN
cord-275433-58unu79x	207	48	CD4	CD4	NNP
cord-275433-58unu79x	207	49	+	+	CC
cord-275433-58unu79x	207	50	T	t	NN
cord-275433-58unu79x	207	51	cells	cell	NNS
cord-275433-58unu79x	207	52	.	.	.
cord-275433-58unu79x	208	1	Cytosolic	cytosolic	JJ
cord-275433-58unu79x	208	2	antigens	antigen	NNS
cord-275433-58unu79x	208	3	that	that	WDT
cord-275433-58unu79x	208	4	contain	contain	VBP
cord-275433-58unu79x	208	5	a	a	DT
cord-275433-58unu79x	208	6	KFERQ	KFERQ	NNP
cord-275433-58unu79x	208	7	recognition	recognition	NN
cord-275433-58unu79x	208	8	motif	motif	NN
cord-275433-58unu79x	208	9	may	may	MD
cord-275433-58unu79x	208	10	also	also	RB
cord-275433-58unu79x	208	11	be	be	VB
cord-275433-58unu79x	208	12	directly	directly	RB
cord-275433-58unu79x	208	13	imported	import	VBN
cord-275433-58unu79x	208	14	into	into	IN
cord-275433-58unu79x	208	15	MIICs	miic	NNS
cord-275433-58unu79x	208	16	by	by	IN
cord-275433-58unu79x	208	17	chaperone	chaperone	NN
cord-275433-58unu79x	208	18	-	-	HYPH
cord-275433-58unu79x	208	19	mediated	mediate	VBN
cord-275433-58unu79x	208	20	autophagy	autophagy	NN
cord-275433-58unu79x	208	21	.	.	.
cord-275433-58unu79x	209	1	CLIP	CLIP	NNP
cord-275433-58unu79x	209	2	,	,	,
cord-275433-58unu79x	209	3	class	class	NN
cord-275433-58unu79x	209	4	II	ii	NN
cord-275433-58unu79x	209	5	-	-	HYPH
cord-275433-58unu79x	209	6	associated	associate	VBN
cord-275433-58unu79x	209	7	invariant	invariant	JJ
cord-275433-58unu79x	209	8	chain	chain	NN
cord-275433-58unu79x	209	9	peptide	peptide	NN
cord-275433-58unu79x	209	10	.	.	.
cord-275433-58unu79x	210	1	(	(	-LRB-
cord-275433-58unu79x	210	2	T	T	NNP
cord-275433-58unu79x	210	3	H	h	NN
cord-275433-58unu79x	210	4	1	1	CD
cord-275433-58unu79x	210	5	cell	cell	NN
cord-275433-58unu79x	210	6	)	)	-RRB-
cord-275433-58unu79x	210	7	.	.	.
cord-275433-58unu79x	211	1	The	the	DT
cord-275433-58unu79x	211	2	term	term	NN
cord-275433-58unu79x	211	3	used	use	VBN
cord-275433-58unu79x	211	4	for	for	IN
cord-275433-58unu79x	211	5	a	a	DT
cord-275433-58unu79x	211	6	CD4	CD4	NNP
cord-275433-58unu79x	211	7	+	+	CC
cord-275433-58unu79x	211	8	T	t	NN
cord-275433-58unu79x	211	9	cell	cell	NN
cord-275433-58unu79x	211	10	that	that	WDT
cord-275433-58unu79x	211	11	has	have	VBZ
cord-275433-58unu79x	211	12	differentiated	differentiate	VBN
cord-275433-58unu79x	211	13	into	into	IN
cord-275433-58unu79x	211	14	a	a	DT
cord-275433-58unu79x	211	15	cell	cell	NN
cord-275433-58unu79x	211	16	that	that	WDT
cord-275433-58unu79x	211	17	produces	produce	VBZ
cord-275433-58unu79x	211	18	the	the	DT
cord-275433-58unu79x	211	19	cytokines	cytokine	NNS
cord-275433-58unu79x	211	20	interferon	interferon	NN
cord-275433-58unu79x	211	21	-	-	HYPH
cord-275433-58unu79x	211	22	γ	γ	NNP
cord-275433-58unu79x	211	23	,	,	,
cord-275433-58unu79x	211	24	lymphotoxin	lymphotoxin	NNP
cord-275433-58unu79x	211	25	-	-	HYPH
cord-275433-58unu79x	211	26	α	α	NN
cord-275433-58unu79x	211	27	and	and	CC
cord-275433-58unu79x	211	28	tumour	tumour	NN
cord-275433-58unu79x	211	29	-	-	HYPH
cord-275433-58unu79x	211	30	necrosis	necrosis	NN
cord-275433-58unu79x	211	31	factor	factor	NN
cord-275433-58unu79x	211	32	,	,	,
cord-275433-58unu79x	211	33	and	and	CC
cord-275433-58unu79x	211	34	supports	support	VBZ
cord-275433-58unu79x	211	35	cell	cell	NN
cord-275433-58unu79x	211	36	-	-	HYPH
cord-275433-58unu79x	211	37	mediated	mediate	VBN
cord-275433-58unu79x	211	38	immunity	immunity	NN
cord-275433-58unu79x	211	39	.	.	.
cord-275433-58unu79x	212	1	(	(	-LRB-
cord-275433-58unu79x	212	2	T	T	NNP
cord-275433-58unu79x	212	3	H	h	NN
cord-275433-58unu79x	212	4	2	2	CD
cord-275433-58unu79x	212	5	cell	cell	NN
cord-275433-58unu79x	212	6	)	)	-RRB-
cord-275433-58unu79x	212	7	.	.	.
cord-275433-58unu79x	213	1	The	the	DT
cord-275433-58unu79x	213	2	term	term	NN
cord-275433-58unu79x	213	3	used	use	VBN
cord-275433-58unu79x	213	4	for	for	IN
cord-275433-58unu79x	213	5	a	a	DT
cord-275433-58unu79x	213	6	CD4	CD4	NNP
cord-275433-58unu79x	213	7	+	+	CC
cord-275433-58unu79x	213	8	T	t	NN
cord-275433-58unu79x	213	9	cell	cell	NN
cord-275433-58unu79x	213	10	that	that	WDT
cord-275433-58unu79x	213	11	has	have	VBZ
cord-275433-58unu79x	213	12	differentiated	differentiate	VBN
cord-275433-58unu79x	213	13	into	into	IN
cord-275433-58unu79x	213	14	a	a	DT
cord-275433-58unu79x	213	15	cell	cell	NN
cord-275433-58unu79x	213	16	that	that	WDT
cord-275433-58unu79x	213	17	produces	produce	VBZ
cord-275433-58unu79x	213	18	interleukin-4	interleukin-4	NNP
cord-275433-58unu79x	213	19	(	(	-LRB-
cord-275433-58unu79x	213	20	IL-4	IL-4	NNP
cord-275433-58unu79x	213	21	)	)	-RRB-
cord-275433-58unu79x	213	22	,	,	,
cord-275433-58unu79x	213	23	IL-5	IL-5	NNP
cord-275433-58unu79x	213	24	and	and	CC
cord-275433-58unu79x	213	25	IL-13	IL-13	NNP
cord-275433-58unu79x	213	26	,	,	,
cord-275433-58unu79x	213	27	supports	support	VBZ
cord-275433-58unu79x	213	28	humoral	humoral	JJ
cord-275433-58unu79x	213	29	immunity	immunity	NN
cord-275433-58unu79x	213	30	and	and	CC
cord-275433-58unu79x	213	31	downregulates	downregulate	VBZ
cord-275433-58unu79x	213	32	T	T	NNP
cord-275433-58unu79x	213	33	H	H	NNP
cord-275433-58unu79x	213	34	1-cell	1-cell	CD
cord-275433-58unu79x	213	35	responses	response	NNS
cord-275433-58unu79x	213	36	.	.	.
cord-275433-58unu79x	214	1	p47	p47	NN
cord-275433-58unu79x	214	2	GTPase	GTPase	NNP
cord-275433-58unu79x	215	1	family	family	NN
cord-275433-58unu79x	215	2	A	a	DT
cord-275433-58unu79x	215	3	group	group	NN
cord-275433-58unu79x	215	4	of	of	IN
cord-275433-58unu79x	215	5	47	47	CD
cord-275433-58unu79x	215	6	-	-	SYM
cord-275433-58unu79x	215	7	48-kDa	48-kda	CD
cord-275433-58unu79x	215	8	proteins	protein	NNS
cord-275433-58unu79x	215	9	that	that	WDT
cord-275433-58unu79x	215	10	are	be	VBP
cord-275433-58unu79x	215	11	produced	produce	VBN
cord-275433-58unu79x	215	12	in	in	IN
cord-275433-58unu79x	215	13	response	response	NN
cord-275433-58unu79x	215	14	to	to	IN
cord-275433-58unu79x	215	15	interferons	interferon	NNS
cord-275433-58unu79x	215	16	(	(	-LRB-
cord-275433-58unu79x	215	17	IFNs	ifn	NNS
cord-275433-58unu79x	215	18	)	)	-RRB-
cord-275433-58unu79x	215	19	and	and	CC
cord-275433-58unu79x	215	20	that	that	WDT
cord-275433-58unu79x	215	21	are	be	VBP
cord-275433-58unu79x	215	22	involved	involve	VBN
cord-275433-58unu79x	215	23	in	in	IN
cord-275433-58unu79x	215	24	resistance	resistance	NN
cord-275433-58unu79x	215	25	to	to	IN
cord-275433-58unu79x	215	26	intracellular	intracellular	JJ
cord-275433-58unu79x	215	27	protozoa	protozoan	NNS
cord-275433-58unu79x	215	28	,	,	,
cord-275433-58unu79x	215	29	bacteria	bacteria	NNS
cord-275433-58unu79x	215	30	and	and	CC
cord-275433-58unu79x	215	31	viruses	virus	NNS
cord-275433-58unu79x	215	32	.	.	.
cord-275433-58unu79x	216	1	Members	member	NNS
cord-275433-58unu79x	216	2	of	of	IN
cord-275433-58unu79x	216	3	this	this	DT
cord-275433-58unu79x	216	4	family	family	NN
cord-275433-58unu79x	216	5	include	include	VBP
cord-275433-58unu79x	216	6	IFNγ	IFNγ	NNS
cord-275433-58unu79x	216	7	-	-	,
cord-275433-58unu79x	216	8	induced	induce	VBN
cord-275433-58unu79x	216	9	GTPase	GTPase	NNP
cord-275433-58unu79x	216	10	(	(	-LRB-
cord-275433-58unu79x	216	11	IGTP	IGTP	NNP
cord-275433-58unu79x	216	12	)	)	-RRB-
cord-275433-58unu79x	216	13	,	,	,
cord-275433-58unu79x	216	14	immunity	immunity	NN
cord-275433-58unu79x	216	15	-	-	HYPH
cord-275433-58unu79x	216	16	related	relate	VBN
cord-275433-58unu79x	216	17	GTPase	GTPase	NNP
cord-275433-58unu79x	216	18	family	family	NN
cord-275433-58unu79x	216	19	,	,	,
cord-275433-58unu79x	216	20	M	M	NNP
cord-275433-58unu79x	216	21	(	(	-LRB-
cord-275433-58unu79x	216	22	IRGM	IRGM	NNP
cord-275433-58unu79x	216	23	;	;	:
cord-275433-58unu79x	216	24	also	also	RB
cord-275433-58unu79x	216	25	known	know	VBN
cord-275433-58unu79x	216	26	as	as	IN
cord-275433-58unu79x	216	27	LRG47	LRG47	NNP
cord-275433-58unu79x	216	28	)	)	-RRB-
cord-275433-58unu79x	216	29	and	and	CC
cord-275433-58unu79x	216	30	T	t	NN
cord-275433-58unu79x	216	31	-	-	HYPH
cord-275433-58unu79x	216	32	cell	cell	NN
cord-275433-58unu79x	216	33	-	-	HYPH
cord-275433-58unu79x	216	34	specific	specific	JJ
cord-275433-58unu79x	216	35	GTPase	gtpase	NN
cord-275433-58unu79x	216	36	(	(	-LRB-
cord-275433-58unu79x	216	37	TGTP	TGTP	NNP
cord-275433-58unu79x	216	38	)	)	-RRB-
cord-275433-58unu79x	216	39	.	.	.
cord-275433-58unu79x	217	1	73	73	CD
cord-275433-58unu79x	217	2	.	.	.
cord-275433-58unu79x	218	1	In	in	IN
cord-275433-58unu79x	218	2	these	these	DT
cord-275433-58unu79x	218	3	cells	cell	NNS
cord-275433-58unu79x	218	4	,	,	,
cord-275433-58unu79x	218	5	at	at	RB
cord-275433-58unu79x	218	6	least	least	RBS
cord-275433-58unu79x	218	7	one	one	CD
cord-275433-58unu79x	218	8	half	half	NN
cord-275433-58unu79x	218	9	of	of	IN
cord-275433-58unu79x	218	10	all	all	DT
cord-275433-58unu79x	218	11	autophagosomes	autophagosome	NNS
cord-275433-58unu79x	218	12	intersect	intersect	VB
cord-275433-58unu79x	218	13	or	or	CC
cord-275433-58unu79x	218	14	fuse	fuse	VB
cord-275433-58unu79x	218	15	with	with	IN
cord-275433-58unu79x	218	16	MHC	MHC	NNP
cord-275433-58unu79x	218	17	-	-	HYPH
cord-275433-58unu79x	218	18	class	class	NN
cord-275433-58unu79x	218	19	-	-	HYPH
cord-275433-58unu79x	218	20	II	ii	NN
cord-275433-58unu79x	218	21	-	-	HYPH
cord-275433-58unu79x	218	22	loading	loading	NN
cord-275433-58unu79x	218	23	compartments	compartment	NNS
cord-275433-58unu79x	218	24	.	.	.
cord-275433-58unu79x	219	1	This	this	DT
cord-275433-58unu79x	219	2	trafficking	traffic	VBG
cord-275433-58unu79x	219	3	pathway	pathway	NN
cord-275433-58unu79x	219	4	may	may	MD
cord-275433-58unu79x	219	5	be	be	VB
cord-275433-58unu79x	219	6	highly	highly	RB
cord-275433-58unu79x	219	7	relevant	relevant	JJ
cord-275433-58unu79x	219	8	for	for	IN
cord-275433-58unu79x	219	9	antigen	antigen	NN
cord-275433-58unu79x	219	10	presentation	presentation	NN
cord-275433-58unu79x	219	11	,	,	,
cord-275433-58unu79x	219	12	as	as	IN
cord-275433-58unu79x	219	13	the	the	DT
cord-275433-58unu79x	219	14	targeting	targeting	NN
cord-275433-58unu79x	219	15	of	of	IN
cord-275433-58unu79x	219	16	an	an	DT
cord-275433-58unu79x	219	17	influenza	influenza	NN
cord-275433-58unu79x	219	18	virus	virus	NN
cord-275433-58unu79x	219	19	matrix	matrix	NN
cord-275433-58unu79x	219	20	protein	protein	NN
cord-275433-58unu79x	219	21	(	(	-LRB-
cord-275433-58unu79x	219	22	MP	MP	NNP
cord-275433-58unu79x	219	23	)	)	-RRB-
cord-275433-58unu79x	219	24	to	to	IN
cord-275433-58unu79x	219	25	autophagosomes	autophagosomes	NNP
cord-275433-58unu79x	219	26	by	by	IN
cord-275433-58unu79x	219	27	fusion	fusion	NN
cord-275433-58unu79x	219	28	with	with	IN
cord-275433-58unu79x	219	29	the	the	DT
cord-275433-58unu79x	219	30	autophagosomal	autophagosomal	NNP
cord-275433-58unu79x	219	31	protein	protein	NN
cord-275433-58unu79x	220	1	LC3	LC3	NNP
cord-275433-58unu79x	220	2	led	lead	VBD
cord-275433-58unu79x	220	3	to	to	IN
cord-275433-58unu79x	220	4	a	a	DT
cord-275433-58unu79x	220	5	20-fold	20-fold	JJ
cord-275433-58unu79x	220	6	enhancement	enhancement	NN
cord-275433-58unu79x	220	7	of	of	IN
cord-275433-58unu79x	220	8	MHC	MHC	NNP
cord-275433-58unu79x	220	9	class	class	NN
cord-275433-58unu79x	220	10	II	II	NNP
cord-275433-58unu79x	220	11	presentation	presentation	NN
cord-275433-58unu79x	220	12	to	to	IN
cord-275433-58unu79x	220	13	MP	MP	NNP
cord-275433-58unu79x	220	14	-	-	HYPH
cord-275433-58unu79x	220	15	specific	specific	JJ
cord-275433-58unu79x	220	16	CD4	CD4	NNP
cord-275433-58unu79x	220	17	+	+	CC
cord-275433-58unu79x	220	18	T	t	NN
cord-275433-58unu79x	220	19	-	-	HYPH
cord-275433-58unu79x	220	20	cell	cell	NN
cord-275433-58unu79x	220	21	clones	clone	NNS
cord-275433-58unu79x	220	22	.	.	.
cord-275433-58unu79x	221	1	This	this	DT
cord-275433-58unu79x	221	2	has	have	VBZ
cord-275433-58unu79x	221	3	exciting	exciting	JJ
cord-275433-58unu79x	221	4	implications	implication	NNS
cord-275433-58unu79x	221	5	for	for	IN
cord-275433-58unu79x	221	6	vaccine	vaccine	NN
cord-275433-58unu79x	221	7	development	development	NN
cord-275433-58unu79x	221	8	;	;	,
cord-275433-58unu79x	221	9	targeting	target	VBG
cord-275433-58unu79x	221	10	proteins	protein	NNS
cord-275433-58unu79x	221	11	for	for	IN
cord-275433-58unu79x	221	12	autophagic	autophagic	JJ
cord-275433-58unu79x	221	13	delivery	delivery	NN
cord-275433-58unu79x	221	14	to	to	IN
cord-275433-58unu79x	221	15	MHC	MHC	NNP
cord-275433-58unu79x	221	16	-	-	HYPH
cord-275433-58unu79x	221	17	class	class	NNP
cord-275433-58unu79x	221	18	-	-	HYPH
cord-275433-58unu79x	221	19	II	ii	NN
cord-275433-58unu79x	221	20	-	-	HYPH
cord-275433-58unu79x	221	21	loading	loading	NN
cord-275433-58unu79x	221	22	compartments	compartment	NNS
cord-275433-58unu79x	221	23	may	may	MD
cord-275433-58unu79x	221	24	be	be	VB
cord-275433-58unu79x	221	25	an	an	DT
cord-275433-58unu79x	221	26	effective	effective	JJ
cord-275433-58unu79x	221	27	means	mean	NNS
cord-275433-58unu79x	221	28	to	to	TO
cord-275433-58unu79x	221	29	improve	improve	VB
cord-275433-58unu79x	221	30	T	T	NNP
cord-275433-58unu79x	221	31	helper	helper	NN
cord-275433-58unu79x	221	32	(	(	-LRB-
cord-275433-58unu79x	221	33	T	T	NNP
cord-275433-58unu79x	221	34	H	h	NN
cord-275433-58unu79x	221	35	)	)	-RRB-
cord-275433-58unu79x	222	1	-cell	-cell	JJS
cord-275433-58unu79x	222	2	responses	response	NNS
cord-275433-58unu79x	222	3	.	.	.
cord-275433-58unu79x	223	1	However	however	RB
cord-275433-58unu79x	223	2	,	,	,
cord-275433-58unu79x	223	3	the	the	DT
cord-275433-58unu79x	223	4	contribution	contribution	NN
cord-275433-58unu79x	223	5	of	of	IN
cord-275433-58unu79x	223	6	autophagic	autophagic	NNP
cord-275433-58unu79x	223	7	delivery	delivery	NN
cord-275433-58unu79x	223	8	of	of	IN
cord-275433-58unu79x	223	9	viral	viral	JJ
cord-275433-58unu79x	223	10	antigens	antigen	NNS
cord-275433-58unu79x	223	11	to	to	IN
cord-275433-58unu79x	223	12	adaptive	adaptive	JJ
cord-275433-58unu79x	223	13	immunity	immunity	NN
cord-275433-58unu79x	223	14	during	during	IN
cord-275433-58unu79x	223	15	natural	natural	JJ
cord-275433-58unu79x	223	16	infections	infection	NNS
cord-275433-58unu79x	223	17	has	have	VBZ
cord-275433-58unu79x	223	18	not	not	RB
cord-275433-58unu79x	223	19	yet	yet	RB
cord-275433-58unu79x	223	20	been	be	VBN
cord-275433-58unu79x	223	21	explored	explore	VBN
cord-275433-58unu79x	223	22	.	.	.
cord-275433-58unu79x	224	1	The	the	DT
cord-275433-58unu79x	224	2	'	'	``
cord-275433-58unu79x	224	3	individualized	individualized	JJ
cord-275433-58unu79x	224	4	'	'	''
cord-275433-58unu79x	224	5	form	form	NN
cord-275433-58unu79x	224	6	of	of	IN
cord-275433-58unu79x	224	7	autophagy	autophagy	NN
cord-275433-58unu79x	224	8	termed	term	VBN
cord-275433-58unu79x	224	9	chaperone	chaperone	NN
cord-275433-58unu79x	224	10	-	-	HYPH
cord-275433-58unu79x	224	11	mediated	mediate	VBN
cord-275433-58unu79x	224	12	autophagy	autophagy	NN
cord-275433-58unu79x	224	13	also	also	RB
cord-275433-58unu79x	224	14	has	have	VBZ
cord-275433-58unu79x	224	15	a	a	DT
cord-275433-58unu79x	224	16	role	role	NN
cord-275433-58unu79x	224	17	in	in	IN
cord-275433-58unu79x	224	18	endogenous	endogenous	JJ
cord-275433-58unu79x	224	19	MHC	MHC	NNP
cord-275433-58unu79x	224	20	class	class	NN
cord-275433-58unu79x	224	21	II	II	NNP
cord-275433-58unu79x	224	22	presentation	presentation	NN
cord-275433-58unu79x	224	23	74	74	CD
cord-275433-58unu79x	224	24	.	.	.
cord-275433-58unu79x	225	1	Chaperonemediated	chaperonemediated	JJ
cord-275433-58unu79x	225	2	autophagy	autophagy	NN
cord-275433-58unu79x	225	3	imports	import	VBZ
cord-275433-58unu79x	225	4	individual	individual	JJ
cord-275433-58unu79x	225	5	cytosolic	cytosolic	JJ
cord-275433-58unu79x	225	6	proteins	protein	NNS
cord-275433-58unu79x	225	7	containing	contain	VBG
cord-275433-58unu79x	225	8	specific	specific	JJ
cord-275433-58unu79x	225	9	pentapeptide	pentapeptide	NN
cord-275433-58unu79x	225	10	recognition	recognition	NN
cord-275433-58unu79x	225	11	motifs	motif	NNS
cord-275433-58unu79x	225	12	into	into	IN
cord-275433-58unu79x	225	13	the	the	DT
cord-275433-58unu79x	225	14	lysosome	lysosome	NN
cord-275433-58unu79x	225	15	via	via	IN
cord-275433-58unu79x	225	16	a	a	DT
cord-275433-58unu79x	225	17	particular	particular	JJ
cord-275433-58unu79x	225	18	isoform	isoform	NN
cord-275433-58unu79x	225	19	of	of	IN
cord-275433-58unu79x	225	20	lysosome	lysosome	NN
cord-275433-58unu79x	225	21	-	-	HYPH
cord-275433-58unu79x	225	22	associated	associate	VBN
cord-275433-58unu79x	225	23	membrane	membrane	NN
cord-275433-58unu79x	225	24	protein	protein	NN
cord-275433-58unu79x	225	25	2	2	CD
cord-275433-58unu79x	225	26	(	(	-LRB-
cord-275433-58unu79x	225	27	LAMP2a	lamp2a	NN
cord-275433-58unu79x	225	28	)	)	-RRB-
cord-275433-58unu79x	225	29	and	and	CC
cord-275433-58unu79x	225	30	an	an	DT
cord-275433-58unu79x	225	31	accessory	accessory	NN
cord-275433-58unu79x	225	32	chaperone	chaperone	NN
cord-275433-58unu79x	225	33	,	,	,
cord-275433-58unu79x	225	34	the	the	DT
cord-275433-58unu79x	225	35	heat	heat	NN
cord-275433-58unu79x	225	36	-	-	HYPH
cord-275433-58unu79x	225	37	shock	shock	NN
cord-275433-58unu79x	225	38	protein	protein	NN
cord-275433-58unu79x	226	1	HSC70	HSC70	NNP
cord-275433-58unu79x	226	2	.	.	.
cord-275433-58unu79x	227	1	Importantly	importantly	RB
cord-275433-58unu79x	227	2	,	,	,
cord-275433-58unu79x	227	3	targeting	target	VBG
cord-275433-58unu79x	227	4	to	to	IN
cord-275433-58unu79x	227	5	the	the	DT
cord-275433-58unu79x	227	6	chaperonemediated	chaperonemediated	JJ
cord-275433-58unu79x	227	7	autophagy	autophagy	NN
cord-275433-58unu79x	227	8	pathway	pathway	NN
cord-275433-58unu79x	227	9	is	be	VBZ
cord-275433-58unu79x	227	10	intrinsic	intrinsic	JJ
cord-275433-58unu79x	227	11	to	to	IN
cord-275433-58unu79x	227	12	a	a	DT
cord-275433-58unu79x	227	13	large	large	JJ
cord-275433-58unu79x	227	14	fraction	fraction	NN
cord-275433-58unu79x	227	15	of	of	IN
cord-275433-58unu79x	227	16	self	self	NN
cord-275433-58unu79x	227	17	proteins	protein	NNS
cord-275433-58unu79x	227	18	,	,	,
cord-275433-58unu79x	227	19	as	as	IN
cord-275433-58unu79x	227	20	the	the	DT
cord-275433-58unu79x	227	21	targeting	targeting	NN
cord-275433-58unu79x	227	22	signal	signal	NN
cord-275433-58unu79x	227	23	(	(	-LRB-
cord-275433-58unu79x	227	24	KFeRQ	KFeRQ	NNP
cord-275433-58unu79x	227	25	)	)	-RRB-
cord-275433-58unu79x	227	26	is	be	VBZ
cord-275433-58unu79x	227	27	present	present	JJ
cord-275433-58unu79x	227	28	in	in	IN
cord-275433-58unu79x	227	29	roughly	roughly	RB
cord-275433-58unu79x	227	30	30	30	CD
cord-275433-58unu79x	227	31	%	%	NN
cord-275433-58unu79x	227	32	of	of	IN
cord-275433-58unu79x	227	33	all	all	DT
cord-275433-58unu79x	227	34	cytosolic	cytosolic	JJ
cord-275433-58unu79x	227	35	proteins	protein	NNS
cord-275433-58unu79x	227	36	75	75	CD
cord-275433-58unu79x	227	37	.	.	.
cord-275433-58unu79x	228	1	Although	although	IN
cord-275433-58unu79x	228	2	the	the	DT
cord-275433-58unu79x	228	3	relative	relative	JJ
cord-275433-58unu79x	228	4	contribution	contribution	NN
cord-275433-58unu79x	228	5	of	of	IN
cord-275433-58unu79x	228	6	autophagy	autophagy	NN
cord-275433-58unu79x	228	7	and	and	CC
cord-275433-58unu79x	228	8	chaperone	chaperone	NN
cord-275433-58unu79x	228	9	-	-	HYPH
cord-275433-58unu79x	228	10	mediated	mediate	VBN
cord-275433-58unu79x	228	11	autophagy	autophagy	NN
cord-275433-58unu79x	228	12	in	in	IN
cord-275433-58unu79x	228	13	endogenous	endogenous	JJ
cord-275433-58unu79x	228	14	MHC	MHC	NNP
cord-275433-58unu79x	228	15	class	class	NN
cord-275433-58unu79x	228	16	II	II	NNP
cord-275433-58unu79x	228	17	antigen	antigen	NN
cord-275433-58unu79x	228	18	presentation	presentation	NN
cord-275433-58unu79x	228	19	is	be	VBZ
cord-275433-58unu79x	228	20	not	not	RB
cord-275433-58unu79x	228	21	yet	yet	RB
cord-275433-58unu79x	228	22	known	know	VBN
cord-275433-58unu79x	228	23	,	,	,
cord-275433-58unu79x	228	24	Zhou	Zhou	NNP
cord-275433-58unu79x	228	25	et	et	NNP
cord-275433-58unu79x	228	26	al	al	NNP
cord-275433-58unu79x	228	27	.	.	.
cord-275433-58unu79x	229	1	have	have	VBP
cord-275433-58unu79x	229	2	shown	show	VBN
cord-275433-58unu79x	229	3	that	that	IN
cord-275433-58unu79x	229	4	chaperone	chaperone	NN
cord-275433-58unu79x	229	5	-	-	HYPH
cord-275433-58unu79x	229	6	mediated	mediate	VBN
cord-275433-58unu79x	229	7	autophagy	autophagy	NN
cord-275433-58unu79x	229	8	may	may	MD
cord-275433-58unu79x	229	9	regulate	regulate	VB
cord-275433-58unu79x	229	10	MHC	MHC	NNP
cord-275433-58unu79x	229	11	class	class	NN
cord-275433-58unu79x	229	12	II	II	NNP
cord-275433-58unu79x	229	13	presentation	presentation	NN
cord-275433-58unu79x	229	14	of	of	IN
cord-275433-58unu79x	229	15	several	several	JJ
cord-275433-58unu79x	229	16	cytoplasmic	cytoplasmic	JJ
cord-275433-58unu79x	229	17	antigens	antigen	NNS
cord-275433-58unu79x	229	18	76	76	CD
cord-275433-58unu79x	229	19	.	.	.
cord-275433-58unu79x	230	1	Overexpression	overexpression	NN
cord-275433-58unu79x	230	2	of	of	IN
cord-275433-58unu79x	230	3	LAMP2a	lamp2a	PRP
cord-275433-58unu79x	230	4	or	or	CC
cord-275433-58unu79x	230	5	HSC70	HSC70	NNP
cord-275433-58unu79x	230	6	increases	increase	VBZ
cord-275433-58unu79x	230	7	cytoplasmic	cytoplasmic	JJ
cord-275433-58unu79x	230	8	self	self	NN
cord-275433-58unu79x	230	9	antigen	antigen	NN
cord-275433-58unu79x	230	10	presentation	presentation	NN
cord-275433-58unu79x	230	11	,	,	,
cord-275433-58unu79x	230	12	and	and	CC
cord-275433-58unu79x	230	13	diminished	diminish	VBD
cord-275433-58unu79x	230	14	HSC70	HSC70	NNP
cord-275433-58unu79x	230	15	expression	expression	NN
cord-275433-58unu79x	230	16	reduces	reduce	VBZ
cord-275433-58unu79x	230	17	MHC	MHC	NNP
cord-275433-58unu79x	230	18	-	-	HYPH
cord-275433-58unu79x	230	19	class	class	NN
cord-275433-58unu79x	230	20	-	-	HYPH
cord-275433-58unu79x	230	21	II	ii	NN
cord-275433-58unu79x	230	22	-	-	HYPH
cord-275433-58unu79x	230	23	restricted	restrict	VBN
cord-275433-58unu79x	230	24	T	t	NN
cord-275433-58unu79x	230	25	-	-	HYPH
cord-275433-58unu79x	230	26	cell	cell	NN
cord-275433-58unu79x	230	27	responses	response	NNS
cord-275433-58unu79x	230	28	to	to	IN
cord-275433-58unu79x	230	29	these	these	DT
cord-275433-58unu79x	230	30	antigens	antigen	NNS
cord-275433-58unu79x	230	31	.	.	.
cord-275433-58unu79x	231	1	Now	now	RB
cord-275433-58unu79x	231	2	that	that	IN
cord-275433-58unu79x	231	3	it	-PRON-	PRP
cord-275433-58unu79x	231	4	is	be	VBZ
cord-275433-58unu79x	231	5	known	know	VBN
cord-275433-58unu79x	231	6	that	that	IN
cord-275433-58unu79x	231	7	autophagic	autophagic	NNP
cord-275433-58unu79x	231	8	pathways	pathway	NNS
cord-275433-58unu79x	231	9	may	may	MD
cord-275433-58unu79x	231	10	have	have	VB
cord-275433-58unu79x	231	11	a	a	DT
cord-275433-58unu79x	231	12	role	role	NN
cord-275433-58unu79x	231	13	in	in	IN
cord-275433-58unu79x	231	14	MHC	MHC	NNP
cord-275433-58unu79x	231	15	class	class	NN
cord-275433-58unu79x	231	16	II	II	NNP
cord-275433-58unu79x	231	17	presentation	presentation	NN
cord-275433-58unu79x	231	18	of	of	IN
cord-275433-58unu79x	231	19	endogenous	endogenous	JJ
cord-275433-58unu79x	231	20	antigen	antigen	NN
cord-275433-58unu79x	231	21	,	,	,
cord-275433-58unu79x	231	22	many	many	JJ
cord-275433-58unu79x	231	23	important	important	JJ
cord-275433-58unu79x	231	24	new	new	JJ
cord-275433-58unu79x	231	25	questions	question	NNS
cord-275433-58unu79x	231	26	arise	arise	VBP
cord-275433-58unu79x	231	27	.	.	.
cord-275433-58unu79x	232	1	How	how	WRB
cord-275433-58unu79x	232	2	important	important	JJ
cord-275433-58unu79x	232	3	are	be	VBP
cord-275433-58unu79x	232	4	these	these	DT
cord-275433-58unu79x	232	5	pathways	pathway	NNS
cord-275433-58unu79x	232	6	for	for	IN
cord-275433-58unu79x	232	7	adaptive	adaptive	JJ
cord-275433-58unu79x	232	8	immunity	immunity	NN
cord-275433-58unu79x	232	9	to	to	IN
cord-275433-58unu79x	232	10	intracellular	intracellular	JJ
cord-275433-58unu79x	232	11	pathogens	pathogen	NNS
cord-275433-58unu79x	232	12	?	?	.
cord-275433-58unu79x	233	1	what	what	WP
cord-275433-58unu79x	233	2	is	be	VBZ
cord-275433-58unu79x	233	3	the	the	DT
cord-275433-58unu79x	233	4	relationship	relationship	NN
cord-275433-58unu79x	233	5	between	between	IN
cord-275433-58unu79x	233	6	autophagic	autophagic	JJ
cord-275433-58unu79x	233	7	elimination	elimination	NN
cord-275433-58unu79x	233	8	of	of	IN
cord-275433-58unu79x	233	9	intracellular	intracellular	JJ
cord-275433-58unu79x	233	10	pathogens	pathogen	NNS
cord-275433-58unu79x	233	11	and	and	CC
cord-275433-58unu79x	233	12	MHC	MHC	NNP
cord-275433-58unu79x	233	13	class	class	NN
cord-275433-58unu79x	233	14	II	II	NNP
cord-275433-58unu79x	233	15	presentation	presentation	NN
cord-275433-58unu79x	233	16	of	of	IN
cord-275433-58unu79x	233	17	microbial	microbial	JJ
cord-275433-58unu79x	233	18	antigens	antigen	NNS
cord-275433-58unu79x	233	19	?	?	.
cord-275433-58unu79x	234	1	Does	do	VBZ
cord-275433-58unu79x	234	2	autophagic	autophagic	JJ
cord-275433-58unu79x	234	3	degradation	degradation	NN
cord-275433-58unu79x	234	4	of	of	IN
cord-275433-58unu79x	234	5	pathogens	pathogen	NNS
cord-275433-58unu79x	234	6	provide	provide	VBP
cord-275433-58unu79x	234	7	a	a	DT
cord-275433-58unu79x	234	8	source	source	NN
cord-275433-58unu79x	234	9	of	of	IN
cord-275433-58unu79x	234	10	antigens	antigen	NNS
cord-275433-58unu79x	234	11	for	for	IN
cord-275433-58unu79x	234	12	loading	load	VBG
cord-275433-58unu79x	234	13	into	into	IN
cord-275433-58unu79x	234	14	MHC	MHC	NNP
cord-275433-58unu79x	234	15	class	class	NN
cord-275433-58unu79x	234	16	II	II	NNP
cord-275433-58unu79x	234	17	compartments	compartment	NNS
cord-275433-58unu79x	234	18	and/or	and/or	CC
cord-275433-58unu79x	234	19	does	do	VBZ
cord-275433-58unu79x	234	20	the	the	DT
cord-275433-58unu79x	234	21	autophagic	autophagic	NNP
cord-275433-58unu79x	234	22	machinery	machinery	NN
cord-275433-58unu79x	234	23	independently	independently	RB
cord-275433-58unu79x	234	24	capture	capture	VBP
cord-275433-58unu79x	234	25	newly	newly	RB
cord-275433-58unu79x	234	26	synthesized	synthesize	VBN
cord-275433-58unu79x	234	27	microbial	microbial	JJ
cord-275433-58unu79x	234	28	peptides	peptide	NNS
cord-275433-58unu79x	234	29	?	?	.
cord-275433-58unu79x	235	1	How	how	WRB
cord-275433-58unu79x	235	2	are	be	VBP
cord-275433-58unu79x	235	3	microbial	microbial	JJ
cord-275433-58unu79x	235	4	(	(	-LRB-
cord-275433-58unu79x	235	5	and	and	CC
cord-275433-58unu79x	235	6	self	self	NN
cord-275433-58unu79x	235	7	)	)	-RRB-
cord-275433-58unu79x	235	8	antigens	antigen	NNS
cord-275433-58unu79x	235	9	targeted	target	VBN
cord-275433-58unu79x	235	10	for	for	IN
cord-275433-58unu79x	235	11	autophagic	autophagic	JJ
cord-275433-58unu79x	235	12	delivery	delivery	NN
cord-275433-58unu79x	235	13	to	to	IN
cord-275433-58unu79x	235	14	MHC	MHC	NNP
cord-275433-58unu79x	235	15	-	-	HYPH
cord-275433-58unu79x	235	16	class	class	NNP
cord-275433-58unu79x	235	17	-	-	HYPH
cord-275433-58unu79x	235	18	II	ii	NN
cord-275433-58unu79x	235	19	-	-	HYPH
cord-275433-58unu79x	235	20	loading	loading	NN
cord-275433-58unu79x	235	21	compartments	compartment	NNS
cord-275433-58unu79x	235	22	?	?	.
cord-275433-58unu79x	236	1	beyond	beyond	IN
cord-275433-58unu79x	236	2	immunity	immunity	NN
cord-275433-58unu79x	236	3	against	against	IN
cord-275433-58unu79x	236	4	infection	infection	NN
cord-275433-58unu79x	236	5	,	,	,
cord-275433-58unu79x	236	6	what	what	WP
cord-275433-58unu79x	236	7	is	be	VBZ
cord-275433-58unu79x	236	8	the	the	DT
cord-275433-58unu79x	236	9	broader	broad	JJR
cord-275433-58unu79x	236	10	significance	significance	NN
cord-275433-58unu79x	236	11	of	of	IN
cord-275433-58unu79x	236	12	autophagic	autophagic	NN
cord-275433-58unu79x	236	13	antigen	antigen	NN
cord-275433-58unu79x	236	14	processing	processing	NN
cord-275433-58unu79x	236	15	and	and	CC
cord-275433-58unu79x	236	16	presentation	presentation	NN
cord-275433-58unu79x	236	17	in	in	IN
cord-275433-58unu79x	236	18	an	an	DT
cord-275433-58unu79x	236	19	MHC	MHC	NNP
cord-275433-58unu79x	236	20	-	-	HYPH
cord-275433-58unu79x	236	21	class	class	NN
cord-275433-58unu79x	236	22	-	-	HYPH
cord-275433-58unu79x	236	23	II	ii	NN
cord-275433-58unu79x	236	24	-	-	HYPH
cord-275433-58unu79x	236	25	dependent	dependent	JJ
cord-275433-58unu79x	236	26	manner	manner	NN
cord-275433-58unu79x	236	27	?	?	.
cord-275433-58unu79x	237	1	It	-PRON-	PRP
cord-275433-58unu79x	237	2	will	will	MD
cord-275433-58unu79x	237	3	be	be	VB
cord-275433-58unu79x	237	4	interesting	interesting	JJ
cord-275433-58unu79x	237	5	to	to	TO
cord-275433-58unu79x	237	6	unravel	unravel	VB
cord-275433-58unu79x	237	7	the	the	DT
cord-275433-58unu79x	237	8	role	role	NN
cord-275433-58unu79x	237	9	of	of	IN
cord-275433-58unu79x	237	10	this	this	DT
cord-275433-58unu79x	237	11	pathway	pathway	NN
cord-275433-58unu79x	237	12	not	not	RB
cord-275433-58unu79x	237	13	only	only	RB
cord-275433-58unu79x	237	14	in	in	IN
cord-275433-58unu79x	237	15	immunity	immunity	NN
cord-275433-58unu79x	237	16	against	against	IN
cord-275433-58unu79x	237	17	infection	infection	NN
cord-275433-58unu79x	237	18	,	,	,
cord-275433-58unu79x	237	19	but	but	CC
cord-275433-58unu79x	237	20	also	also	RB
cord-275433-58unu79x	237	21	in	in	IN
cord-275433-58unu79x	237	22	cancer	cancer	NN
cord-275433-58unu79x	237	23	immunology	immunology	NN
cord-275433-58unu79x	237	24	,	,	,
cord-275433-58unu79x	237	25	central	central	JJ
cord-275433-58unu79x	237	26	and	and	CC
cord-275433-58unu79x	237	27	peripheral	peripheral	JJ
cord-275433-58unu79x	237	28	tolerance	tolerance	NN
cord-275433-58unu79x	237	29	,	,	,
cord-275433-58unu79x	237	30	autoimmunity	autoimmunity	NN
cord-275433-58unu79x	237	31	and	and	CC
cord-275433-58unu79x	237	32	transplant	transplant	NN
cord-275433-58unu79x	237	33	rejection	rejection	NN
cord-275433-58unu79x	237	34	.	.	.
cord-275433-58unu79x	238	1	Autophagy	autophagy	JJ
cord-275433-58unu79x	238	2	regulation	regulation	NN
cord-275433-58unu79x	238	3	by	by	IN
cord-275433-58unu79x	238	4	immune	immune	JJ
cord-275433-58unu79x	238	5	signals	signal	NNS
cord-275433-58unu79x	239	1	The	the	DT
cord-275433-58unu79x	239	2	relationship	relationship	NN
cord-275433-58unu79x	239	3	between	between	IN
cord-275433-58unu79x	239	4	autophagy	autophagy	NN
cord-275433-58unu79x	239	5	and	and	CC
cord-275433-58unu79x	239	6	immunity	immunity	NN
cord-275433-58unu79x	239	7	is	be	VBZ
cord-275433-58unu79x	239	8	bidirectional	bidirectional	JJ
cord-275433-58unu79x	239	9	.	.	.
cord-275433-58unu79x	240	1	Not	not	RB
cord-275433-58unu79x	240	2	only	only	RB
cord-275433-58unu79x	240	3	does	do	VBZ
cord-275433-58unu79x	240	4	autophagy	autophagy	NN
cord-275433-58unu79x	240	5	,	,	,
cord-275433-58unu79x	240	6	at	at	IN
cord-275433-58unu79x	240	7	least	least	JJS
cord-275433-58unu79x	240	8	in	in	IN
cord-275433-58unu79x	240	9	certain	certain	JJ
cord-275433-58unu79x	240	10	contexts	context	NNS
cord-275433-58unu79x	240	11	,	,	,
cord-275433-58unu79x	240	12	enhance	enhance	VB
cord-275433-58unu79x	240	13	innate	innate	JJ
cord-275433-58unu79x	240	14	and	and	CC
cord-275433-58unu79x	240	15	adaptive	adaptive	JJ
cord-275433-58unu79x	240	16	immune	immune	JJ
cord-275433-58unu79x	240	17	responses	response	NNS
cord-275433-58unu79x	240	18	,	,	,
cord-275433-58unu79x	240	19	but	but	CC
cord-275433-58unu79x	240	20	in	in	IN
cord-275433-58unu79x	240	21	parallel	parallel	NN
cord-275433-58unu79x	240	22	,	,	,
cord-275433-58unu79x	240	23	cytokines	cytokine	NNS
cord-275433-58unu79x	240	24	,	,	,
cord-275433-58unu79x	240	25	receptors	receptor	NNS
cord-275433-58unu79x	240	26	and	and	CC
cord-275433-58unu79x	240	27	ligands	ligand	NNS
cord-275433-58unu79x	240	28	involved	involve	VBN
cord-275433-58unu79x	240	29	in	in	IN
cord-275433-58unu79x	240	30	innate	innate	JJ
cord-275433-58unu79x	240	31	and	and	CC
cord-275433-58unu79x	240	32	adaptive	adaptive	JJ
cord-275433-58unu79x	240	33	immunity	immunity	NN
cord-275433-58unu79x	240	34	enhance	enhance	NN
cord-275433-58unu79x	240	35	autophagy	autophagy	NN
cord-275433-58unu79x	240	36	.	.	.
cord-275433-58unu79x	241	1	Immune	immune	JJ
cord-275433-58unu79x	241	2	signalling	signal	VBG
cord-275433-58unu79x	241	3	molecules	molecule	NNS
cord-275433-58unu79x	241	4	that	that	WDT
cord-275433-58unu79x	241	5	have	have	VBP
cord-275433-58unu79x	241	6	been	be	VBN
cord-275433-58unu79x	241	7	shown	show	VBN
cord-275433-58unu79x	241	8	to	to	TO
cord-275433-58unu79x	241	9	positively	positively	RB
cord-275433-58unu79x	241	10	regulate	regulate	VB
cord-275433-58unu79x	241	11	autophagy	autophagy	NN
cord-275433-58unu79x	241	12	in	in	IN
cord-275433-58unu79x	241	13	some	some	DT
cord-275433-58unu79x	241	14	contexts	context	NNS
cord-275433-58unu79x	241	15	include	include	VBP
cord-275433-58unu79x	241	16	PKR	PKR	NNP
cord-275433-58unu79x	241	17	77	77	CD
cord-275433-58unu79x	241	18	,	,	,
cord-275433-58unu79x	241	19	IFNγ	IFNγ	NNS
cord-275433-58unu79x	241	20	(	(	-LRB-
cord-275433-58unu79x	241	21	and	and	CC
cord-275433-58unu79x	241	22	its	-PRON-	PRP$
cord-275433-58unu79x	241	23	downstream	downstream	JJ
cord-275433-58unu79x	241	24	effector	effector	NN
cord-275433-58unu79x	241	25	immunity	immunity	NN
cord-275433-58unu79x	241	26	-	-	HYPH
cord-275433-58unu79x	241	27	related	relate	VBN
cord-275433-58unu79x	241	28	GTPases	gtpase	NNS
cord-275433-58unu79x	241	29	)	)	-RRB-
cord-275433-58unu79x	241	30	9	9	CD
cord-275433-58unu79x	241	31	,	,	,
cord-275433-58unu79x	241	32	42	42	CD
cord-275433-58unu79x	241	33	,	,	,
cord-275433-58unu79x	241	34	45	45	CD
cord-275433-58unu79x	241	35	,	,	,
cord-275433-58unu79x	241	36	78	78	CD
cord-275433-58unu79x	241	37	,	,	,
cord-275433-58unu79x	241	38	79	79	CD
cord-275433-58unu79x	241	39	,	,	,
cord-275433-58unu79x	241	40	tumour	tumour	NN
cord-275433-58unu79x	241	41	-	-	HYPH
cord-275433-58unu79x	241	42	necrosis	necrosis	NN
cord-275433-58unu79x	241	43	factor	factor	NN
cord-275433-58unu79x	241	44	(	(	-LRB-
cord-275433-58unu79x	241	45	TNF	TNF	NNP
cord-275433-58unu79x	241	46	)	)	-RRB-
cord-275433-58unu79x	241	47	53	53	CD
cord-275433-58unu79x	241	48	,	,	,
cord-275433-58unu79x	241	49	80	80	CD
cord-275433-58unu79x	241	50	,	,	,
cord-275433-58unu79x	241	51	81	81	CD
cord-275433-58unu79x	241	52	,	,	,
cord-275433-58unu79x	241	53	and	and	CC
cord-275433-58unu79x	241	54	the	the	DT
cord-275433-58unu79x	241	55	CD40-CD40L	cd40-cd40l	NN
cord-275433-58unu79x	241	56	(	(	-LRB-
cord-275433-58unu79x	241	57	CD40	CD40	NNP
cord-275433-58unu79x	241	58	ligand	ligand	NN
cord-275433-58unu79x	241	59	)	)	-RRB-
cord-275433-58unu79x	241	60	interaction	interaction	NN
cord-275433-58unu79x	241	61	8	8	CD
cord-275433-58unu79x	241	62	.	.	.
cord-275433-58unu79x	242	1	by	by	IN
cord-275433-58unu79x	242	2	contrast	contrast	NN
cord-275433-58unu79x	242	3	,	,	,
cord-275433-58unu79x	242	4	autophagy	autophagy	NN
cord-275433-58unu79x	242	5	is	be	VBZ
cord-275433-58unu79x	242	6	negatively	negatively	RB
cord-275433-58unu79x	242	7	regulated	regulate	VBN
cord-275433-58unu79x	242	8	by	by	IN
cord-275433-58unu79x	242	9	the	the	DT
cord-275433-58unu79x	242	10	T	T	NNP
cord-275433-58unu79x	242	11	H	H	NNP
cord-275433-58unu79x	242	12	2-type	2-type	CD
cord-275433-58unu79x	242	13	cytokines	cytokine	NNS
cord-275433-58unu79x	242	14	,	,	,
cord-275433-58unu79x	242	15	interleukin-4	interleukin-4	NNP
cord-275433-58unu79x	242	16	(	(	-LRB-
cord-275433-58unu79x	242	17	IL-4	IL-4	NNP
cord-275433-58unu79x	242	18	)	)	-RRB-
cord-275433-58unu79x	242	19	and	and	CC
cord-275433-58unu79x	242	20	IL-13	IL-13	NNP
cord-275433-58unu79x	242	21	,	,	,
cord-275433-58unu79x	242	22	although	although	IN
cord-275433-58unu79x	242	23	this	this	DT
cord-275433-58unu79x	242	24	has	have	VBZ
cord-275433-58unu79x	242	25	been	be	VBN
cord-275433-58unu79x	242	26	shown	show	VBN
cord-275433-58unu79x	242	27	so	so	RB
cord-275433-58unu79x	242	28	far	far	RB
cord-275433-58unu79x	242	29	only	only	RB
cord-275433-58unu79x	242	30	in	in	IN
cord-275433-58unu79x	242	31	a	a	DT
cord-275433-58unu79x	242	32	non	non	JJ
cord-275433-58unu79x	242	33	-	-	JJ
cord-275433-58unu79x	242	34	immune	immune	JJ
cord-275433-58unu79x	242	35	cell	cell	NN
cord-275433-58unu79x	242	36	line	line	NN
cord-275433-58unu79x	242	37	82	82	CD
cord-275433-58unu79x	242	38	-	-	SYM
cord-275433-58unu79x	242	39	84	84	CD
cord-275433-58unu79x	242	40	.	.	.
cord-275433-58unu79x	243	1	In	in	IN
cord-275433-58unu79x	243	2	general	general	JJ
cord-275433-58unu79x	243	3	,	,	,
cord-275433-58unu79x	243	4	there	there	EX
cord-275433-58unu79x	243	5	is	be	VBZ
cord-275433-58unu79x	243	6	a	a	DT
cord-275433-58unu79x	243	7	correlation	correlation	NN
cord-275433-58unu79x	243	8	between	between	IN
cord-275433-58unu79x	243	9	activation	activation	NN
cord-275433-58unu79x	243	10	of	of	IN
cord-275433-58unu79x	243	11	autophagy	autophagy	NN
cord-275433-58unu79x	243	12	by	by	IN
cord-275433-58unu79x	243	13	immune	immune	JJ
cord-275433-58unu79x	243	14	mediators	mediator	NNS
cord-275433-58unu79x	243	15	and	and	CC
cord-275433-58unu79x	243	16	the	the	DT
cord-275433-58unu79x	243	17	control	control	NN
cord-275433-58unu79x	243	18	of	of	IN
cord-275433-58unu79x	243	19	infection	infection	NN
cord-275433-58unu79x	243	20	with	with	IN
cord-275433-58unu79x	243	21	intracellular	intracellular	JJ
cord-275433-58unu79x	243	22	pathogens	pathogen	NNS
cord-275433-58unu79x	243	23	.	.	.
cord-275433-58unu79x	244	1	The	the	DT
cord-275433-58unu79x	244	2	PKR	PKR	NNP
cord-275433-58unu79x	244	3	signalling	signal	VBG
cord-275433-58unu79x	244	4	pathway	pathway	NN
cord-275433-58unu79x	244	5	is	be	VBZ
cord-275433-58unu79x	244	6	an	an	DT
cord-275433-58unu79x	244	7	important	important	JJ
cord-275433-58unu79x	244	8	arm	arm	NN
cord-275433-58unu79x	244	9	of	of	IN
cord-275433-58unu79x	244	10	the	the	DT
cord-275433-58unu79x	244	11	innate	innate	JJ
cord-275433-58unu79x	244	12	defence	defence	NN
cord-275433-58unu79x	244	13	pathway	pathway	NN
cord-275433-58unu79x	244	14	against	against	IN
cord-275433-58unu79x	244	15	viruses	virus	NNS
cord-275433-58unu79x	244	16	85	85	CD
cord-275433-58unu79x	244	17	and	and	CC
cord-275433-58unu79x	244	18	is	be	VBZ
cord-275433-58unu79x	244	19	required	require	VBN
cord-275433-58unu79x	244	20	for	for	IN
cord-275433-58unu79x	244	21	virusinduced	virusinduced	JJ
cord-275433-58unu79x	244	22	autophagy	autophagy	NN
cord-275433-58unu79x	244	23	55	55	CD
cord-275433-58unu79x	244	24	,	,	,
cord-275433-58unu79x	244	25	77	77	CD
cord-275433-58unu79x	244	26	.	.	.
cord-275433-58unu79x	245	1	Cell	cell	NN
cord-275433-58unu79x	245	2	-	-	HYPH
cord-275433-58unu79x	245	3	mediated	mediate	VBN
cord-275433-58unu79x	245	4	immunity	immunity	NN
cord-275433-58unu79x	245	5	can	can	MD
cord-275433-58unu79x	245	6	induce	induce	VB
cord-275433-58unu79x	245	7	autophagy	autophagy	NN
cord-275433-58unu79x	245	8	through	through	IN
cord-275433-58unu79x	245	9	CD40-CD40L	cd40-cd40l	CC
cord-275433-58unu79x	245	10	stimulation	stimulation	NN
cord-275433-58unu79x	245	11	and	and	CC
cord-275433-58unu79x	245	12	protect	protect	VB
cord-275433-58unu79x	245	13	target	target	NN
cord-275433-58unu79x	245	14	cells	cell	NNS
cord-275433-58unu79x	245	15	against	against	IN
cord-275433-58unu79x	245	16	the	the	DT
cord-275433-58unu79x	245	17	vacuolar	vacuolar	JJ
cord-275433-58unu79x	245	18	parasite	parasite	NN
cord-275433-58unu79x	245	19	T.	T.	NNP
cord-275433-58unu79x	245	20	gondii	gondii	NNP
cord-275433-58unu79x	245	21	8	8	CD
cord-275433-58unu79x	245	22	.	.	.
cord-275433-58unu79x	246	1	IFNγ	IFNγ	NNP
cord-275433-58unu79x	246	2	and	and	CC
cord-275433-58unu79x	246	3	TNF	TNF	NNP
cord-275433-58unu79x	246	4	are	be	VBP
cord-275433-58unu79x	246	5	crucial	crucial	JJ
cord-275433-58unu79x	246	6	for	for	IN
cord-275433-58unu79x	246	7	protection	protection	NN
cord-275433-58unu79x	246	8	against	against	IN
cord-275433-58unu79x	246	9	infection	infection	NN
cord-275433-58unu79x	246	10	by	by	IN
cord-275433-58unu79x	246	11	mycobacteria	mycobacterium	NNS
cord-275433-58unu79x	246	12	and	and	CC
cord-275433-58unu79x	246	13	other	other	JJ
cord-275433-58unu79x	246	14	pathogens	pathogen	NNS
cord-275433-58unu79x	246	15	that	that	WDT
cord-275433-58unu79x	246	16	replicate	replicate	VBP
cord-275433-58unu79x	246	17	in	in	IN
cord-275433-58unu79x	246	18	macrophages	macrophage	NNS
cord-275433-58unu79x	246	19	,	,	,
cord-275433-58unu79x	246	20	and	and	CC
cord-275433-58unu79x	246	21	are	be	VBP
cord-275433-58unu79x	246	22	potent	potent	JJ
cord-275433-58unu79x	246	23	inducers	inducer	NNS
cord-275433-58unu79x	246	24	of	of	IN
cord-275433-58unu79x	246	25	autophagy	autophagy	NN
cord-275433-58unu79x	246	26	in	in	IN
cord-275433-58unu79x	246	27	both	both	DT
cord-275433-58unu79x	246	28	macrophages	macrophage	NNS
cord-275433-58unu79x	246	29	and	and	CC
cord-275433-58unu79x	246	30	other	other	JJ
cord-275433-58unu79x	246	31	cell	cell	NN
cord-275433-58unu79x	246	32	types	type	NNS
cord-275433-58unu79x	246	33	9	9	CD
cord-275433-58unu79x	246	34	,	,	,
cord-275433-58unu79x	246	35	42	42	CD
cord-275433-58unu79x	246	36	,	,	,
cord-275433-58unu79x	246	37	45	45	CD
cord-275433-58unu79x	246	38	,	,	,
cord-275433-58unu79x	246	39	53	53	CD
cord-275433-58unu79x	246	40	,	,	,
cord-275433-58unu79x	246	41	[	[	-LRB-
cord-275433-58unu79x	246	42	78	78	CD
cord-275433-58unu79x	246	43	]	]	-RRB-
cord-275433-58unu79x	246	44	[	[	-LRB-
cord-275433-58unu79x	246	45	79	79	CD
cord-275433-58unu79x	246	46	]	]	-RRB-
cord-275433-58unu79x	247	1	[	[	-LRB-
cord-275433-58unu79x	247	2	80	80	CD
cord-275433-58unu79x	247	3	]	]	-RRB-
cord-275433-58unu79x	247	4	[	[	-LRB-
cord-275433-58unu79x	247	5	81	81	CD
cord-275433-58unu79x	247	6	]	]	-RRB-
cord-275433-58unu79x	247	7	.	.	.
cord-275433-58unu79x	248	1	It	-PRON-	PRP
cord-275433-58unu79x	248	2	is	be	VBZ
cord-275433-58unu79x	248	3	interesting	interesting	JJ
cord-275433-58unu79x	248	4	to	to	TO
cord-275433-58unu79x	248	5	note	note	VB
cord-275433-58unu79x	248	6	the	the	DT
cord-275433-58unu79x	248	7	contrasting	contrast	VBG
cord-275433-58unu79x	248	8	roles	role	NNS
cord-275433-58unu79x	248	9	that	that	WDT
cord-275433-58unu79x	248	10	the	the	DT
cord-275433-58unu79x	248	11	T	T	NNP
cord-275433-58unu79x	248	12	H	H	NNP
cord-275433-58unu79x	248	13	1-type	1-type	CD
cord-275433-58unu79x	248	14	cytokines	cytokine	NNS
cord-275433-58unu79x	248	15	IFNγ	IFNγ	NNS
cord-275433-58unu79x	248	16	and	and	CC
cord-275433-58unu79x	248	17	TNF	TNF	NNP
cord-275433-58unu79x	248	18	,	,	,
cord-275433-58unu79x	248	19	and	and	CC
cord-275433-58unu79x	248	20	the	the	DT
cord-275433-58unu79x	248	21	T	T	NNP
cord-275433-58unu79x	248	22	H	H	NNP
cord-275433-58unu79x	248	23	2-type	2-type	CD
cord-275433-58unu79x	248	24	cytokines	cytokine	NNS
cord-275433-58unu79x	248	25	IL-4	IL-4	NNP
cord-275433-58unu79x	248	26	and	and	CC
cord-275433-58unu79x	248	27	IL-13	IL-13	NNP
cord-275433-58unu79x	248	28	(	(	-LRB-
cord-275433-58unu79x	248	29	REF	ref	NN
cord-275433-58unu79x	248	30	.	.	.
cord-275433-58unu79x	248	31	81	81	CD
cord-275433-58unu79x	248	32	)	)	-RRB-
cord-275433-58unu79x	248	33	may	may	MD
cord-275433-58unu79x	248	34	have	have	VB
cord-275433-58unu79x	248	35	on	on	IN
cord-275433-58unu79x	248	36	the	the	DT
cord-275433-58unu79x	248	37	regulation	regulation	NN
cord-275433-58unu79x	248	38	of	of	IN
cord-275433-58unu79x	248	39	autophagy	autophagy	NN
cord-275433-58unu79x	248	40	.	.	.
cord-275433-58unu79x	249	1	Perhaps	perhaps	RB
cord-275433-58unu79x	249	2	,	,	,
cord-275433-58unu79x	249	3	T	T	NNP
cord-275433-58unu79x	249	4	H	H	NNP
cord-275433-58unu79x	249	5	1-cell	1-cell	CD
cord-275433-58unu79x	249	6	responses	response	NNS
cord-275433-58unu79x	249	7	activate	activate	VBP
cord-275433-58unu79x	249	8	autophagy	autophagy	NN
cord-275433-58unu79x	249	9	,	,	,
cord-275433-58unu79x	249	10	thereby	thereby	RB
cord-275433-58unu79x	249	11	affording	afford	VBG
cord-275433-58unu79x	249	12	protection	protection	NN
cord-275433-58unu79x	249	13	against	against	IN
cord-275433-58unu79x	249	14	intracellular	intracellular	JJ
cord-275433-58unu79x	249	15	microorganisms	microorganism	NNS
cord-275433-58unu79x	249	16	,	,	,
cord-275433-58unu79x	249	17	whereas	whereas	IN
cord-275433-58unu79x	249	18	T	T	NNP
cord-275433-58unu79x	249	19	H	h	NN
cord-275433-58unu79x	249	20	2-cell	2-cell	CD
cord-275433-58unu79x	249	21	responses	response	NNS
cord-275433-58unu79x	249	22	dampen	dampen	VBP
cord-275433-58unu79x	249	23	the	the	DT
cord-275433-58unu79x	249	24	autophagic	autophagic	JJ
cord-275433-58unu79x	249	25	response	response	NN
cord-275433-58unu79x	249	26	,	,	,
cord-275433-58unu79x	249	27	thus	thus	RB
cord-275433-58unu79x	249	28	,	,	,
cord-275433-58unu79x	249	29	potentially	potentially	RB
cord-275433-58unu79x	249	30	explaining	explain	VBG
cord-275433-58unu79x	249	31	the	the	DT
cord-275433-58unu79x	249	32	negative	negative	JJ
cord-275433-58unu79x	249	33	role	role	NN
cord-275433-58unu79x	249	34	that	that	WDT
cord-275433-58unu79x	249	35	the	the	DT
cord-275433-58unu79x	249	36	T	t	NN
cord-275433-58unu79x	249	37	H	h	NN
cord-275433-58unu79x	249	38	2-cell	2-cell	CD
cord-275433-58unu79x	249	39	response	response	NN
cord-275433-58unu79x	249	40	has	have	VBZ
cord-275433-58unu79x	249	41	in	in	IN
cord-275433-58unu79x	249	42	the	the	DT
cord-275433-58unu79x	249	43	control	control	NN
cord-275433-58unu79x	249	44	of	of	IN
cord-275433-58unu79x	249	45	intracellular	intracellular	JJ
cord-275433-58unu79x	249	46	pathogens	pathogen	NNS
cord-275433-58unu79x	249	47	86	86	CD
cord-275433-58unu79x	249	48	.	.	.
cord-275433-58unu79x	250	1	p47	p47	CD
cord-275433-58unu79x	250	2	GTPase	GTPase	NNP
cord-275433-58unu79x	250	3	-	-	HYPH
cord-275433-58unu79x	250	4	mediated	mediate	VBN
cord-275433-58unu79x	250	5	regulation	regulation	NN
cord-275433-58unu79x	250	6	of	of	IN
cord-275433-58unu79x	250	7	autophagy	autophagy	NN
cord-275433-58unu79x	250	8	.	.	.
cord-275433-58unu79x	251	1	Recent	recent	JJ
cord-275433-58unu79x	251	2	advances	advance	NNS
cord-275433-58unu79x	251	3	have	have	VBP
cord-275433-58unu79x	251	4	been	be	VBN
cord-275433-58unu79x	251	5	made	make	VBN
cord-275433-58unu79x	251	6	in	in	IN
cord-275433-58unu79x	251	7	identifying	identify	VBG
cord-275433-58unu79x	251	8	the	the	DT
cord-275433-58unu79x	251	9	molecular	molecular	JJ
cord-275433-58unu79x	251	10	mechanisms	mechanism	NNS
cord-275433-58unu79x	251	11	that	that	WDT
cord-275433-58unu79x	251	12	underlie	underlie	VBP
cord-275433-58unu79x	251	13	the	the	DT
cord-275433-58unu79x	251	14	antimicrobial	antimicrobial	JJ
cord-275433-58unu79x	251	15	action	action	NN
cord-275433-58unu79x	251	16	of	of	IN
cord-275433-58unu79x	251	17	IFNγ	ifnγ	NN
cord-275433-58unu79x	251	18	-	-	HYPH
cord-275433-58unu79x	251	19	induced	induce	VBN
cord-275433-58unu79x	251	20	autophagy	autophagy	NN
cord-275433-58unu79x	251	21	.	.	.
cord-275433-58unu79x	252	1	The	the	DT
cord-275433-58unu79x	252	2	mouse	mouse	NN
cord-275433-58unu79x	252	3	genome	genome	NN
cord-275433-58unu79x	252	4	contains	contain	VBZ
cord-275433-58unu79x	252	5	23	23	CD
cord-275433-58unu79x	252	6	different	different	JJ
cord-275433-58unu79x	252	7	immunity	immunity	NN
cord-275433-58unu79x	252	8	-	-	HYPH
cord-275433-58unu79x	252	9	related	relate	VBN
cord-275433-58unu79x	252	10	GTPases	gtpase	NNS
cord-275433-58unu79x	252	11	that	that	WDT
cord-275433-58unu79x	252	12	are	be	VBP
cord-275433-58unu79x	252	13	responsive	responsive	JJ
cord-275433-58unu79x	252	14	to	to	IN
cord-275433-58unu79x	252	15	IFNγ	IFNγ	NNS
cord-275433-58unu79x	252	16	and	and	CC
cord-275433-58unu79x	252	17	that	that	WDT
cord-275433-58unu79x	252	18	have	have	VBP
cord-275433-58unu79x	252	19	been	be	VBN
cord-275433-58unu79x	252	20	long	long	RB
cord-275433-58unu79x	252	21	known	know	VBN
cord-275433-58unu79x	252	22	to	to	TO
cord-275433-58unu79x	252	23	have	have	VB
cord-275433-58unu79x	252	24	a	a	DT
cord-275433-58unu79x	252	25	role	role	NN
cord-275433-58unu79x	252	26	in	in	IN
cord-275433-58unu79x	252	27	defence	defence	NN
cord-275433-58unu79x	252	28	against	against	IN
cord-275433-58unu79x	252	29	a	a	DT
cord-275433-58unu79x	252	30	wide	wide	JJ
cord-275433-58unu79x	252	31	range	range	NN
cord-275433-58unu79x	252	32	of	of	IN
cord-275433-58unu79x	252	33	intracellular	intracellular	JJ
cord-275433-58unu79x	252	34	pathogens	pathogen	NNS
cord-275433-58unu79x	252	35	87	87	CD
cord-275433-58unu79x	252	36	.	.	.
cord-275433-58unu79x	253	1	However	however	RB
cord-275433-58unu79x	253	2	,	,	,
cord-275433-58unu79x	253	3	until	until	IN
cord-275433-58unu79x	253	4	recently	recently	RB
cord-275433-58unu79x	253	5	,	,	,
cord-275433-58unu79x	253	6	the	the	DT
cord-275433-58unu79x	253	7	mechanisms	mechanism	NNS
cord-275433-58unu79x	253	8	by	by	IN
cord-275433-58unu79x	253	9	which	which	WDT
cord-275433-58unu79x	253	10	these	these	DT
cord-275433-58unu79x	253	11	immunity	immunity	NN
cord-275433-58unu79x	253	12	-	-	HYPH
cord-275433-58unu79x	253	13	related	relate	VBN
cord-275433-58unu79x	253	14	GTPases	gtpase	NNS
cord-275433-58unu79x	253	15	control	control	NN
cord-275433-58unu79x	253	16	intracellular	intracellular	JJ
cord-275433-58unu79x	253	17	pathogens	pathogen	NNS
cord-275433-58unu79x	253	18	have	have	VBP
cord-275433-58unu79x	253	19	remained	remain	VBN
cord-275433-58unu79x	253	20	unclear	unclear	JJ
cord-275433-58unu79x	253	21	,	,	,
cord-275433-58unu79x	253	22	as	as	IN
cord-275433-58unu79x	253	23	has	have	VBZ
cord-275433-58unu79x	253	24	the	the	DT
cord-275433-58unu79x	253	25	question	question	NN
cord-275433-58unu79x	253	26	of	of	IN
cord-275433-58unu79x	253	27	whether	whether	IN
cord-275433-58unu79x	253	28	human	human	JJ
cord-275433-58unu79x	253	29	immunity	immunity	NN
cord-275433-58unu79x	253	30	-	-	HYPH
cord-275433-58unu79x	253	31	related	relate	VBN
cord-275433-58unu79x	253	32	GTPases	gtpase	NNS
cord-275433-58unu79x	253	33	have	have	VBP
cord-275433-58unu79x	253	34	a	a	DT
cord-275433-58unu79x	253	35	similar	similar	JJ
cord-275433-58unu79x	253	36	role	role	NN
cord-275433-58unu79x	253	37	in	in	IN
cord-275433-58unu79x	253	38	defence	defence	NN
cord-275433-58unu79x	253	39	against	against	IN
cord-275433-58unu79x	253	40	intracellular	intracellular	JJ
cord-275433-58unu79x	253	41	pathogens	pathogen	NNS
cord-275433-58unu79x	253	42	.	.	.
cord-275433-58unu79x	254	1	This	this	DT
cord-275433-58unu79x	254	2	has	have	VBZ
cord-275433-58unu79x	254	3	been	be	VBN
cord-275433-58unu79x	254	4	partially	partially	RB
cord-275433-58unu79x	254	5	resolved	resolve	VBN
cord-275433-58unu79x	254	6	by	by	IN
cord-275433-58unu79x	254	7	the	the	DT
cord-275433-58unu79x	254	8	recent	recent	JJ
cord-275433-58unu79x	254	9	discoveries	discovery	NNS
cord-275433-58unu79x	254	10	that	that	WDT
cord-275433-58unu79x	254	11	both	both	CC
cord-275433-58unu79x	254	12	the	the	DT
cord-275433-58unu79x	254	13	mouse	mouse	NN
cord-275433-58unu79x	254	14	and	and	CC
cord-275433-58unu79x	254	15	human	human	NNP
cord-275433-58unu79x	254	16	p47	p47	CD
cord-275433-58unu79x	255	1	GTPase	GTPase	NNP
cord-275433-58unu79x	255	2	family	family	NN
cord-275433-58unu79x	255	3	member	member	NN
cord-275433-58unu79x	255	4	immunity	immunity	NN
cord-275433-58unu79x	255	5	-	-	HYPH
cord-275433-58unu79x	255	6	related	relate	VBN
cord-275433-58unu79x	255	7	GTPase	GTPase	NNP
cord-275433-58unu79x	255	8	family	family	NN
cord-275433-58unu79x	255	9	,	,	,
cord-275433-58unu79x	255	10	M	M	NNP
cord-275433-58unu79x	255	11	(	(	-LRB-
cord-275433-58unu79x	255	12	IRGM	IRGM	NNP
cord-275433-58unu79x	255	13	;	;	:
cord-275433-58unu79x	255	14	also	also	RB
cord-275433-58unu79x	255	15	known	know	VBN
cord-275433-58unu79x	255	16	as	as	IN
cord-275433-58unu79x	255	17	LRG47	LRG47	NNP
cord-275433-58unu79x	255	18	)	)	-RRB-
cord-275433-58unu79x	255	19	are	be	VBP
cord-275433-58unu79x	255	20	required	require	VBN
cord-275433-58unu79x	255	21	for	for	IN
cord-275433-58unu79x	255	22	IFNγ	IFNγ	NNS
cord-275433-58unu79x	255	23	-	-	HYPH
cord-275433-58unu79x	255	24	induced	induce	VBN
cord-275433-58unu79x	255	25	autophagy	autophagy	NN
cord-275433-58unu79x	255	26	and	and	CC
cord-275433-58unu79x	255	27	antimycobacterial	antimycobacterial	JJ
cord-275433-58unu79x	255	28	activity	activity	NN
cord-275433-58unu79x	255	29	in	in	IN
cord-275433-58unu79x	255	30	macrophages	macrophage	NNS
cord-275433-58unu79x	255	31	42	42	CD
cord-275433-58unu79x	255	32	,	,	,
cord-275433-58unu79x	255	33	45	45	CD
cord-275433-58unu79x	255	34	,	,	,
cord-275433-58unu79x	255	35	and	and	CC
cord-275433-58unu79x	255	36	that	that	IN
cord-275433-58unu79x	255	37	mouse	mouse	NN
cord-275433-58unu79x	255	38	IRGM	IRGM	NNP
cord-275433-58unu79x	255	39	is	be	VBZ
cord-275433-58unu79x	255	40	also	also	RB
cord-275433-58unu79x	255	41	required	require	VBN
cord-275433-58unu79x	255	42	for	for	IN
cord-275433-58unu79x	255	43	antiparasitic	antiparasitic	JJ
cord-275433-58unu79x	255	44	activity	activity	NN
cord-275433-58unu79x	255	45	associated	associate	VBN
cord-275433-58unu79x	255	46	with	with	IN
cord-275433-58unu79x	255	47	macrophage	macrophage	NN
cord-275433-58unu79x	255	48	autophagy	autophagy	NN
cord-275433-58unu79x	255	49	9	9	CD
cord-275433-58unu79x	255	50	.	.	.
cord-275433-58unu79x	256	1	Although	although	IN
cord-275433-58unu79x	256	2	the	the	DT
cord-275433-58unu79x	256	3	expression	expression	NN
cord-275433-58unu79x	256	4	of	of	IN
cord-275433-58unu79x	256	5	human	human	JJ
cord-275433-58unu79x	256	6	IRGM	IRGM	NNP
cord-275433-58unu79x	256	7	is	be	VBZ
cord-275433-58unu79x	256	8	not	not	RB
cord-275433-58unu79x	256	9	regulated	regulate	VBN
cord-275433-58unu79x	256	10	by	by	IN
cord-275433-58unu79x	256	11	IFNγ	IFNγ	NNS
cord-275433-58unu79x	256	12	,	,	,
cord-275433-58unu79x	256	13	cells	cell	NNS
cord-275433-58unu79x	256	14	must	must	MD
cord-275433-58unu79x	256	15	be	be	VB
cord-275433-58unu79x	256	16	stimulated	stimulate	VBN
cord-275433-58unu79x	256	17	with	with	IN
cord-275433-58unu79x	256	18	this	this	DT
cord-275433-58unu79x	256	19	cytokine	cytokine	NN
cord-275433-58unu79x	256	20	,	,	,
cord-275433-58unu79x	256	21	or	or	CC
cord-275433-58unu79x	256	22	other	other	JJ
cord-275433-58unu79x	256	23	physiological	physiological	JJ
cord-275433-58unu79x	256	24	or	or	CC
cord-275433-58unu79x	256	25	pharmacological	pharmacological	JJ
cord-275433-58unu79x	256	26	inducers	inducer	NNS
cord-275433-58unu79x	256	27	of	of	IN
cord-275433-58unu79x	256	28	autophagy	autophagy	NN
cord-275433-58unu79x	256	29	,	,	,
cord-275433-58unu79x	256	30	for	for	IN
cord-275433-58unu79x	256	31	IRGM	IRGM	NNP
cord-275433-58unu79x	256	32	to	to	TO
cord-275433-58unu79x	256	33	exert	exert	VB
cord-275433-58unu79x	256	34	its	-PRON-	PRP$
cord-275433-58unu79x	256	35	action	action	NN
cord-275433-58unu79x	256	36	.	.	.
cord-275433-58unu79x	257	1	The	the	DT
cord-275433-58unu79x	257	2	exact	exact	JJ
cord-275433-58unu79x	257	3	mechanisms	mechanism	NNS
cord-275433-58unu79x	257	4	by	by	IN
cord-275433-58unu79x	257	5	which	which	WDT
cord-275433-58unu79x	257	6	IRGM	IRGM	NNP
cord-275433-58unu79x	257	7	promotes	promote	VBZ
cord-275433-58unu79x	257	8	autophagy	autophagy	NN
cord-275433-58unu79x	257	9	are	be	VBP
cord-275433-58unu79x	257	10	not	not	RB
cord-275433-58unu79x	257	11	known	know	VBN
cord-275433-58unu79x	257	12	,	,	,
cord-275433-58unu79x	257	13	but	but	CC
cord-275433-58unu79x	257	14	they	-PRON-	PRP
cord-275433-58unu79x	257	15	may	may	MD
cord-275433-58unu79x	257	16	depend	depend	VB
cord-275433-58unu79x	257	17	on	on	IN
cord-275433-58unu79x	257	18	direct	direct	JJ
cord-275433-58unu79x	257	19	or	or	CC
cord-275433-58unu79x	257	20	indirect	indirect	JJ
cord-275433-58unu79x	257	21	interactions	interaction	NNS
cord-275433-58unu79x	257	22	with	with	IN
cord-275433-58unu79x	257	23	organelles	organelle	NNS
cord-275433-58unu79x	257	24	,	,	,
cord-275433-58unu79x	257	25	regulators	regulator	NNS
cord-275433-58unu79x	257	26	or	or	CC
cord-275433-58unu79x	257	27	effectors	effector	NNS
cord-275433-58unu79x	257	28	of	of	IN
cord-275433-58unu79x	257	29	the	the	DT
cord-275433-58unu79x	257	30	autophagic	autophagic	NNP
cord-275433-58unu79x	257	31	pathway	pathway	NN
cord-275433-58unu79x	257	32	.	.	.
cord-275433-58unu79x	258	1	Alternatively	alternatively	RB
cord-275433-58unu79x	258	2	,	,	,
cord-275433-58unu79x	258	3	in	in	IN
cord-275433-58unu79x	258	4	view	view	NN
cord-275433-58unu79x	258	5	of	of	IN
cord-275433-58unu79x	258	6	the	the	DT
cord-275433-58unu79x	258	7	putative	putative	JJ
cord-275433-58unu79x	258	8	function	function	NN
cord-275433-58unu79x	258	9	of	of	IN
cord-275433-58unu79x	258	10	IRGM	IRGM	NNP
cord-275433-58unu79x	258	11	as	as	IN
cord-275433-58unu79x	258	12	a	a	DT
cord-275433-58unu79x	258	13	dynamin	dynamin	NN
cord-275433-58unu79x	258	14	-	-	HYPH
cord-275433-58unu79x	258	15	like	like	JJ
cord-275433-58unu79x	258	16	membrane	membrane	NN
cord-275433-58unu79x	258	17	remodelling	remodelling	NN
cord-275433-58unu79x	258	18	protein	protein	NN
cord-275433-58unu79x	258	19	,	,	,
cord-275433-58unu79x	258	20	autophagy	autophagy	NN
cord-275433-58unu79x	258	21	induction	induction	NN
cord-275433-58unu79x	258	22	may	may	MD
cord-275433-58unu79x	258	23	be	be	VB
cord-275433-58unu79x	258	24	indirectly	indirectly	RB
cord-275433-58unu79x	258	25	promoted	promote	VBN
cord-275433-58unu79x	258	26	by	by	IN
cord-275433-58unu79x	258	27	IRGM	IRGM	NNP
cord-275433-58unu79x	258	28	-	-	HYPH
cord-275433-58unu79x	258	29	induced	induce	VBN
cord-275433-58unu79x	258	30	changes	change	NNS
cord-275433-58unu79x	258	31	to	to	IN
cord-275433-58unu79x	258	32	the	the	DT
cord-275433-58unu79x	258	33	parasitic	parasitic	JJ
cord-275433-58unu79x	258	34	vacuole	vacuole	NN
cord-275433-58unu79x	258	35	membrane	membrane	NN
cord-275433-58unu79x	258	36	.	.	.
cord-275433-58unu79x	259	1	Autophagy	Autophagy	NNP
cord-275433-58unu79x	259	2	and	and	CC
cord-275433-58unu79x	259	3	T	t	NN
cord-275433-58unu79x	259	4	-	-	HYPH
cord-275433-58unu79x	259	5	cell	cell	NN
cord-275433-58unu79x	259	6	homeostasis	homeostasis	NN
cord-275433-58unu79x	259	7	Autophagy	Autophagy	NNP
cord-275433-58unu79x	259	8	has	have	VBZ
cord-275433-58unu79x	259	9	a	a	DT
cord-275433-58unu79x	259	10	central	central	JJ
cord-275433-58unu79x	259	11	role	role	NN
cord-275433-58unu79x	259	12	in	in	IN
cord-275433-58unu79x	259	13	life	life	NN
cord-275433-58unu79x	259	14	and	and	CC
cord-275433-58unu79x	259	15	death	death	NN
cord-275433-58unu79x	259	16	decisions	decision	NNS
cord-275433-58unu79x	259	17	of	of	IN
cord-275433-58unu79x	259	18	numerous	numerous	JJ
cord-275433-58unu79x	259	19	cell	cell	NN
cord-275433-58unu79x	259	20	types	type	NNS
cord-275433-58unu79x	259	21	across	across	IN
cord-275433-58unu79x	259	22	diverse	diverse	JJ
cord-275433-58unu79x	259	23	phyla	phylum	NNS
cord-275433-58unu79x	259	24	,	,	,
cord-275433-58unu79x	259	25	functioning	function	VBG
cord-275433-58unu79x	259	26	both	both	CC
cord-275433-58unu79x	259	27	as	as	IN
cord-275433-58unu79x	259	28	a	a	DT
cord-275433-58unu79x	259	29	pro	pro	JJ
cord-275433-58unu79x	259	30	-	-	JJ
cord-275433-58unu79x	259	31	survival	survival	JJ
cord-275433-58unu79x	259	32	mechanism	mechanism	NN
cord-275433-58unu79x	259	33	during	during	IN
cord-275433-58unu79x	259	34	nutrient	nutrient	NN
cord-275433-58unu79x	259	35	deprivation	deprivation	NN
cord-275433-58unu79x	259	36	and	and	CC
cord-275433-58unu79x	259	37	other	other	JJ
cord-275433-58unu79x	259	38	forms	form	NNS
cord-275433-58unu79x	259	39	of	of	IN
cord-275433-58unu79x	259	40	cell	cell	NN
cord-275433-58unu79x	259	41	stress	stress	NN
cord-275433-58unu79x	259	42	and	and	CC
cord-275433-58unu79x	259	43	as	as	IN
cord-275433-58unu79x	259	44	a	a	DT
cord-275433-58unu79x	259	45	cell	cell	NN
cord-275433-58unu79x	259	46	-	-	HYPH
cord-275433-58unu79x	259	47	death	death	NN
cord-275433-58unu79x	259	48	mechanism	mechanism	NN
cord-275433-58unu79x	259	49	in	in	IN
cord-275433-58unu79x	259	50	other	other	JJ
cord-275433-58unu79x	259	51	contexts	context	NNS
cord-275433-58unu79x	259	52	,	,	,
cord-275433-58unu79x	259	53	such	such	JJ
cord-275433-58unu79x	259	54	as	as	IN
cord-275433-58unu79x	259	55	in	in	IN
cord-275433-58unu79x	259	56	cells	cell	NNS
cord-275433-58unu79x	259	57	defective	defective	JJ
cord-275433-58unu79x	259	58	in	in	IN
cord-275433-58unu79x	259	59	apoptosis	apoptosis	NN
cord-275433-58unu79x	259	60	and	and	CC
cord-275433-58unu79x	259	61	in	in	IN
cord-275433-58unu79x	259	62	cells	cell	NNS
cord-275433-58unu79x	259	63	with	with	IN
cord-275433-58unu79x	259	64	very	very	RB
cord-275433-58unu79x	259	65	high	high	JJ
cord-275433-58unu79x	259	66	levels	level	NNS
cord-275433-58unu79x	259	67	of	of	IN
cord-275433-58unu79x	259	68	autophagy	autophagy	NN
cord-275433-58unu79x	259	69	88	88	CD
cord-275433-58unu79x	259	70	,	,	,
cord-275433-58unu79x	259	71	89	89	CD
cord-275433-58unu79x	259	72	.	.	.
cord-275433-58unu79x	260	1	Recent	recent	JJ
cord-275433-58unu79x	260	2	studies	study	NNS
cord-275433-58unu79x	260	3	indicate	indicate	VBP
cord-275433-58unu79x	260	4	that	that	IN
cord-275433-58unu79x	260	5	this	this	DT
cord-275433-58unu79x	260	6	homeostatic	homeostatic	JJ
cord-275433-58unu79x	260	7	role	role	NN
cord-275433-58unu79x	260	8	of	of	IN
cord-275433-58unu79x	260	9	autophagy	autophagy	NN
cord-275433-58unu79x	260	10	extends	extend	VBZ
cord-275433-58unu79x	260	11	to	to	IN
cord-275433-58unu79x	260	12	T	t	NN
cord-275433-58unu79x	260	13	cells	cell	NNS
cord-275433-58unu79x	260	14	.	.	.
cord-275433-58unu79x	261	1	Pools	pool	NNS
cord-275433-58unu79x	261	2	of	of	IN
cord-275433-58unu79x	261	3	mature	mature	JJ
cord-275433-58unu79x	261	4	T	t	NN
cord-275433-58unu79x	261	5	cells	cell	NNS
cord-275433-58unu79x	261	6	in	in	IN
cord-275433-58unu79x	261	7	the	the	DT
cord-275433-58unu79x	261	8	periphery	periphery	NN
cord-275433-58unu79x	261	9	are	be	VBP
cord-275433-58unu79x	261	10	subject	subject	JJ
cord-275433-58unu79x	261	11	to	to	IN
cord-275433-58unu79x	261	12	tight	tight	JJ
cord-275433-58unu79x	261	13	regulation	regulation	NN
cord-275433-58unu79x	261	14	that	that	WDT
cord-275433-58unu79x	261	15	must	must	MD
cord-275433-58unu79x	261	16	balance	balance	VB
cord-275433-58unu79x	261	17	naive	naive	JJ
cord-275433-58unu79x	261	18	T	t	NN
cord-275433-58unu79x	261	19	-	-	HYPH
cord-275433-58unu79x	261	20	cell	cell	NN
cord-275433-58unu79x	261	21	flux	flux	NN
cord-275433-58unu79x	261	22	following	follow	VBG
cord-275433-58unu79x	261	23	thymic	thymic	JJ
cord-275433-58unu79x	261	24	selection	selection	NN
cord-275433-58unu79x	261	25	with	with	IN
cord-275433-58unu79x	261	26	effector	effector	JJ
cord-275433-58unu79x	261	27	T	t	NN
cord-275433-58unu79x	261	28	-	-	HYPH
cord-275433-58unu79x	261	29	cell	cell	NN
cord-275433-58unu79x	261	30	proliferation	proliferation	NN
cord-275433-58unu79x	261	31	,	,	,
cord-275433-58unu79x	261	32	cell	cell	NN
cord-275433-58unu79x	261	33	death	death	NN
cord-275433-58unu79x	261	34	and	and	CC
cord-275433-58unu79x	261	35	differentiation	differentiation	NN
cord-275433-58unu79x	261	36	.	.	.
cord-275433-58unu79x	262	1	A	a	DT
cord-275433-58unu79x	262	2	role	role	NN
cord-275433-58unu79x	262	3	for	for	IN
cord-275433-58unu79x	262	4	autophagy	autophagy	NN
cord-275433-58unu79x	262	5	in	in	IN
cord-275433-58unu79x	262	6	T	t	NN
cord-275433-58unu79x	262	7	-	-	HYPH
cord-275433-58unu79x	262	8	cell	cell	NN
cord-275433-58unu79x	262	9	survival	survival	NN
cord-275433-58unu79x	262	10	and	and	CC
cord-275433-58unu79x	262	11	proliferation	proliferation	NN
cord-275433-58unu79x	262	12	has	have	VBZ
cord-275433-58unu79x	262	13	been	be	VBN
cord-275433-58unu79x	262	14	shown	show	VBN
cord-275433-58unu79x	262	15	in	in	IN
cord-275433-58unu79x	262	16	vivo	vivo	NN
cord-275433-58unu79x	262	17	using	use	VBG
cord-275433-58unu79x	262	18	lethally	lethally	RB
cord-275433-58unu79x	262	19	irradiated	irradiate	VBN
cord-275433-58unu79x	262	20	mice	mouse	NNS
cord-275433-58unu79x	262	21	repopulated	repopulate	VBD
cord-275433-58unu79x	262	22	with	with	IN
cord-275433-58unu79x	262	23	haematopoietic	haematopoietic	JJ
cord-275433-58unu79x	262	24	cells	cell	NNS
cord-275433-58unu79x	262	25	from	from	IN
cord-275433-58unu79x	262	26	fetal	fetal	JJ
cord-275433-58unu79x	262	27	livers	liver	NNS
cord-275433-58unu79x	262	28	of	of	IN
cord-275433-58unu79x	262	29	Atg5	atg5	JJ
cord-275433-58unu79x	262	30	-/mice	-/mice	NNP
cord-275433-58unu79x	262	31	13	13	CD
cord-275433-58unu79x	262	32	.	.	.
cord-275433-58unu79x	263	1	CD4	CD4	NNP
cord-275433-58unu79x	263	2	+	+	CC
cord-275433-58unu79x	263	3	and	and	CC
cord-275433-58unu79x	263	4	CD8	CD8	NNP
cord-275433-58unu79x	263	5	+	+	CC
cord-275433-58unu79x	263	6	T	T	NNP
cord-275433-58unu79x	263	7	cells	cell	NNS
cord-275433-58unu79x	263	8	from	from	IN
cord-275433-58unu79x	263	9	Atg5	atg5	JJ
cord-275433-58unu79x	263	10	-/mice	-/mice	NN
cord-275433-58unu79x	263	11	fail	fail	VB
cord-275433-58unu79x	263	12	to	to	TO
cord-275433-58unu79x	263	13	undergo	undergo	VB
cord-275433-58unu79x	263	14	efficient	efficient	JJ
cord-275433-58unu79x	263	15	proliferation	proliferation	NN
cord-275433-58unu79x	263	16	after	after	IN
cord-275433-58unu79x	263	17	T	t	NN
cord-275433-58unu79x	263	18	-	-	HYPH
cord-275433-58unu79x	263	19	cell	cell	NN
cord-275433-58unu79x	263	20	receptor	receptor	NN
cord-275433-58unu79x	263	21	stimulation	stimulation	NN
cord-275433-58unu79x	263	22	.	.	.
cord-275433-58unu79x	264	1	Moreover	moreover	RB
cord-275433-58unu79x	264	2	,	,	,
cord-275433-58unu79x	264	3	Atg5	Atg5	NNP
cord-275433-58unu79x	264	4	-/-T	-/-T	NNP
cord-275433-58unu79x	264	5	cells	cell	NNS
cord-275433-58unu79x	264	6	develop	develop	VBP
cord-275433-58unu79x	264	7	normally	normally	RB
cord-275433-58unu79x	264	8	in	in	IN
cord-275433-58unu79x	264	9	the	the	DT
cord-275433-58unu79x	264	10	recipient	recipient	NN
cord-275433-58unu79x	264	11	thymus	thymus	NN
cord-275433-58unu79x	264	12	,	,	,
cord-275433-58unu79x	264	13	but	but	CC
cord-275433-58unu79x	264	14	fail	fail	VB
cord-275433-58unu79x	264	15	to	to	TO
cord-275433-58unu79x	264	16	repopulate	repopulate	VB
cord-275433-58unu79x	264	17	the	the	DT
cord-275433-58unu79x	264	18	periphery	periphery	NN
cord-275433-58unu79x	264	19	due	due	IN
cord-275433-58unu79x	264	20	to	to	IN
cord-275433-58unu79x	264	21	overwhelming	overwhelming	JJ
cord-275433-58unu79x	264	22	cell	cell	NN
cord-275433-58unu79x	264	23	death	death	NN
cord-275433-58unu79x	264	24	.	.	.
cord-275433-58unu79x	265	1	One	one	CD
cord-275433-58unu79x	265	2	interpretation	interpretation	NN
cord-275433-58unu79x	265	3	of	of	IN
cord-275433-58unu79x	265	4	this	this	DT
cord-275433-58unu79x	265	5	finding	finding	NN
cord-275433-58unu79x	265	6	is	be	VBZ
cord-275433-58unu79x	265	7	that	that	IN
cord-275433-58unu79x	265	8	T	T	NNP
cord-275433-58unu79x	265	9	cells	cell	NNS
cord-275433-58unu79x	265	10	,	,	,
cord-275433-58unu79x	265	11	on	on	IN
cord-275433-58unu79x	265	12	exit	exit	NN
cord-275433-58unu79x	265	13	from	from	IN
cord-275433-58unu79x	265	14	the	the	DT
cord-275433-58unu79x	265	15	thymus	thymus	NN
cord-275433-58unu79x	265	16	,	,	,
cord-275433-58unu79x	265	17	become	become	VBP
cord-275433-58unu79x	265	18	exposed	expose	VBN
cord-275433-58unu79x	265	19	to	to	IN
cord-275433-58unu79x	265	20	nutritional	nutritional	JJ
cord-275433-58unu79x	265	21	stress	stress	NN
cord-275433-58unu79x	265	22	owing	owe	VBG
cord-275433-58unu79x	265	23	to	to	IN
cord-275433-58unu79x	265	24	limitations	limitation	NNS
cord-275433-58unu79x	265	25	in	in	IN
cord-275433-58unu79x	265	26	trophic	trophic	JJ
cord-275433-58unu79x	265	27	factor	factor	NN
cord-275433-58unu79x	265	28	support	support	NN
cord-275433-58unu79x	265	29	(	(	-LRB-
cord-275433-58unu79x	265	30	such	such	JJ
cord-275433-58unu79x	265	31	as	as	IN
cord-275433-58unu79x	265	32	IL-7	IL-7	NNP
cord-275433-58unu79x	265	33	)	)	-RRB-
cord-275433-58unu79x	265	34	and	and	CC
cord-275433-58unu79x	265	35	require	require	VB
cord-275433-58unu79x	265	36	autophagy	autophagy	NN
cord-275433-58unu79x	265	37	to	to	TO
cord-275433-58unu79x	265	38	sustain	sustain	VB
cord-275433-58unu79x	265	39	them	-PRON-	PRP
cord-275433-58unu79x	265	40	during	during	IN
cord-275433-58unu79x	265	41	this	this	DT
cord-275433-58unu79x	265	42	period	period	NN
cord-275433-58unu79x	265	43	.	.	.
cord-275433-58unu79x	266	1	At	at	IN
cord-275433-58unu79x	266	2	present	present	NN
cord-275433-58unu79x	266	3	,	,	,
cord-275433-58unu79x	266	4	it	-PRON-	PRP
cord-275433-58unu79x	266	5	is	be	VBZ
cord-275433-58unu79x	266	6	not	not	RB
cord-275433-58unu79x	266	7	known	know	VBN
cord-275433-58unu79x	266	8	how	how	WRB
cord-275433-58unu79x	266	9	autophagy	autophagy	NN
cord-275433-58unu79x	266	10	affects	affect	VBZ
cord-275433-58unu79x	266	11	immunological	immunological	JJ
cord-275433-58unu79x	266	12	memory	memory	NN
cord-275433-58unu79x	266	13	,	,	,
cord-275433-58unu79x	266	14	but	but	CC
cord-275433-58unu79x	266	15	based	base	VBN
cord-275433-58unu79x	266	16	on	on	IN
cord-275433-58unu79x	266	17	its	-PRON-	PRP$
cord-275433-58unu79x	266	18	role	role	NN
cord-275433-58unu79x	266	19	in	in	IN
cord-275433-58unu79x	266	20	the	the	DT
cord-275433-58unu79x	266	21	maintenance	maintenance	NN
cord-275433-58unu79x	266	22	of	of	IN
cord-275433-58unu79x	266	23	other	other	JJ
cord-275433-58unu79x	266	24	long	long	RB
cord-275433-58unu79x	266	25	-	-	HYPH
cord-275433-58unu79x	266	26	lived	live	VBN
cord-275433-58unu79x	266	27	cells	cell	NNS
cord-275433-58unu79x	266	28	,	,	,
cord-275433-58unu79x	266	29	such	such	JJ
cord-275433-58unu79x	266	30	as	as	IN
cord-275433-58unu79x	266	31	neurons	neuron	NNS
cord-275433-58unu79x	266	32	,	,	,
cord-275433-58unu79x	266	33	the	the	DT
cord-275433-58unu79x	266	34	prediction	prediction	NN
cord-275433-58unu79x	266	35	is	be	VBZ
cord-275433-58unu79x	266	36	that	that	IN
cord-275433-58unu79x	266	37	autophagy	autophagy	NN
cord-275433-58unu79x	266	38	may	may	MD
cord-275433-58unu79x	266	39	also	also	RB
cord-275433-58unu79x	266	40	have	have	VB
cord-275433-58unu79x	266	41	a	a	DT
cord-275433-58unu79x	266	42	role	role	NN
cord-275433-58unu79x	266	43	in	in	IN
cord-275433-58unu79x	266	44	maintaining	maintain	VBG
cord-275433-58unu79x	266	45	memory	memory	NN
cord-275433-58unu79x	266	46	T	t	NN
cord-275433-58unu79x	266	47	cells	cell	NNS
cord-275433-58unu79x	266	48	.	.	.
cord-275433-58unu79x	267	1	In	in	IN
cord-275433-58unu79x	267	2	contrast	contrast	NN
cord-275433-58unu79x	267	3	to	to	IN
cord-275433-58unu79x	267	4	its	-PRON-	PRP$
cord-275433-58unu79x	267	5	function	function	NN
cord-275433-58unu79x	267	6	as	as	IN
cord-275433-58unu79x	267	7	a	a	DT
cord-275433-58unu79x	267	8	T	t	NN
cord-275433-58unu79x	267	9	-	-	HYPH
cord-275433-58unu79x	267	10	cell	cell	NN
cord-275433-58unu79x	267	11	survival	survival	NN
cord-275433-58unu79x	267	12	process	process	NN
cord-275433-58unu79x	267	13	,	,	,
cord-275433-58unu79x	267	14	excessive	excessive	JJ
cord-275433-58unu79x	267	15	autophagy	autophagy	NN
cord-275433-58unu79x	267	16	has	have	VBZ
cord-275433-58unu79x	267	17	been	be	VBN
cord-275433-58unu79x	267	18	linked	link	VBN
cord-275433-58unu79x	267	19	to	to	IN
cord-275433-58unu79x	267	20	the	the	DT
cord-275433-58unu79x	267	21	cell	cell	NN
cord-275433-58unu79x	267	22	death	death	NN
cord-275433-58unu79x	267	23	of	of	IN
cord-275433-58unu79x	267	24	effector	effector	NN
cord-275433-58unu79x	267	25	T	t	NN
cord-275433-58unu79x	267	26	cells	cell	NNS
cord-275433-58unu79x	267	27	under	under	IN
cord-275433-58unu79x	267	28	conditions	condition	NNS
cord-275433-58unu79x	267	29	that	that	WDT
cord-275433-58unu79x	267	30	model	model	VBP
cord-275433-58unu79x	267	31	normal	normal	JJ
cord-275433-58unu79x	267	32	homeostasis	homeostasis	NN
cord-275433-58unu79x	267	33	.	.	.
cord-275433-58unu79x	268	1	Li	Li	NNP
cord-275433-58unu79x	268	2	et	et	NNP
cord-275433-58unu79x	268	3	al	al	NNP
cord-275433-58unu79x	268	4	.	.	.
cord-275433-58unu79x	269	1	found	find	VBD
cord-275433-58unu79x	269	2	that	that	IN
cord-275433-58unu79x	269	3	T	T	NNP
cord-275433-58unu79x	269	4	H	h	NN
cord-275433-58unu79x	269	5	2	2	CD
cord-275433-58unu79x	269	6	cells	cell	NNS
cord-275433-58unu79x	269	7	become	become	VBP
cord-275433-58unu79x	269	8	more	more	RBR
cord-275433-58unu79x	269	9	resistant	resistant	JJ
cord-275433-58unu79x	269	10	to	to	IN
cord-275433-58unu79x	269	11	cell	cell	NN
cord-275433-58unu79x	269	12	death	death	NN
cord-275433-58unu79x	269	13	induced	induce	VBN
cord-275433-58unu79x	269	14	by	by	IN
cord-275433-58unu79x	269	15	growth	growth	NN
cord-275433-58unu79x	269	16	-	-	HYPH
cord-275433-58unu79x	269	17	factor	factor	NN
cord-275433-58unu79x	269	18	withdrawal	withdrawal	NN
cord-275433-58unu79x	269	19	when	when	WRB
cord-275433-58unu79x	269	20	autophagy	autophagy	NN
cord-275433-58unu79x	269	21	is	be	VBZ
cord-275433-58unu79x	269	22	blocked	block	VBN
cord-275433-58unu79x	269	23	using	use	VBG
cord-275433-58unu79x	269	24	pharmacological	pharmacological	JJ
cord-275433-58unu79x	269	25	or	or	CC
cord-275433-58unu79x	269	26	genetic	genetic	JJ
cord-275433-58unu79x	269	27	methods	method	NNS
cord-275433-58unu79x	269	28	14	14	CD
cord-275433-58unu79x	269	29	.	.	.
cord-275433-58unu79x	270	1	This	this	DT
cord-275433-58unu79x	270	2	cell	cell	NN
cord-275433-58unu79x	270	3	death	death	NN
cord-275433-58unu79x	270	4	process	process	NN
cord-275433-58unu79x	270	5	may	may	MD
cord-275433-58unu79x	270	6	be	be	VB
cord-275433-58unu79x	270	7	exploited	exploit	VBN
cord-275433-58unu79x	270	8	by	by	IN
cord-275433-58unu79x	270	9	viruses	virus	NNS
cord-275433-58unu79x	270	10	such	such	JJ
cord-275433-58unu79x	270	11	as	as	IN
cord-275433-58unu79x	270	12	HIv	HIv	NNP
cord-275433-58unu79x	270	13	,	,	,
cord-275433-58unu79x	270	14	as	as	IN
cord-275433-58unu79x	270	15	the	the	DT
cord-275433-58unu79x	270	16	HIv	HIv	NNP
cord-275433-58unu79x	270	17	envelope	envelope	NN
cord-275433-58unu79x	270	18	glycoprotein	glycoprotein	NN
cord-275433-58unu79x	270	19	has	have	VBZ
cord-275433-58unu79x	270	20	been	be	VBN
cord-275433-58unu79x	270	21	shown	show	VBN
cord-275433-58unu79x	270	22	to	to	TO
cord-275433-58unu79x	270	23	induce	induce	VB
cord-275433-58unu79x	270	24	autophagic	autophagic	JJ
cord-275433-58unu79x	270	25	cell	cell	NN
cord-275433-58unu79x	270	26	death	death	NN
cord-275433-58unu79x	270	27	by	by	IN
cord-275433-58unu79x	270	28	binding	bind	VBG
cord-275433-58unu79x	270	29	to	to	IN
cord-275433-58unu79x	270	30	CXC	CXC	NNP
cord-275433-58unu79x	270	31	-	-	HYPH
cord-275433-58unu79x	270	32	chemokine	chemokine	NN
cord-275433-58unu79x	270	33	receptor	receptor	NN
cord-275433-58unu79x	270	34	4	4	CD
cord-275433-58unu79x	270	35	(	(	-LRB-
cord-275433-58unu79x	270	36	CXCR4	CXCR4	NNP
cord-275433-58unu79x	270	37	)	)	-RRB-
cord-275433-58unu79x	270	38	in	in	IN
cord-275433-58unu79x	270	39	uninfected	uninfected	JJ
cord-275433-58unu79x	270	40	bystander	bystander	NN
cord-275433-58unu79x	270	41	CD4	CD4	NNP
cord-275433-58unu79x	270	42	+	+	CC
cord-275433-58unu79x	270	43	T	t	NN
cord-275433-58unu79x	270	44	cells	cell	NNS
cord-275433-58unu79x	270	45	90	90	CD
cord-275433-58unu79x	270	46	.	.	.
cord-275433-58unu79x	271	1	However	however	RB
cord-275433-58unu79x	271	2	,	,	,
cord-275433-58unu79x	271	3	in	in	IN
cord-275433-58unu79x	271	4	CD4	CD4	NNP
cord-275433-58unu79x	271	5	+	+	CC
cord-275433-58unu79x	271	6	T	t	NN
cord-275433-58unu79x	271	7	cells	cell	NNS
cord-275433-58unu79x	271	8	,	,	,
cord-275433-58unu79x	271	9	the	the	DT
cord-275433-58unu79x	271	10	natural	natural	JJ
cord-275433-58unu79x	271	11	ligand	ligand	NN
cord-275433-58unu79x	271	12	of	of	IN
cord-275433-58unu79x	271	13	CXCR4	CXCR4	NNP
cord-275433-58unu79x	271	14	,	,	,
cord-275433-58unu79x	271	15	CXC	CXC	NNP
cord-275433-58unu79x	271	16	-	-	HYPH
cord-275433-58unu79x	271	17	chemokine	chemokine	NN
cord-275433-58unu79x	271	18	ligand	ligand	NN
cord-275433-58unu79x	271	19	12	12	CD
cord-275433-58unu79x	271	20	(	(	-LRB-
cord-275433-58unu79x	271	21	CXCL12	CXCL12	NNP
cord-275433-58unu79x	271	22	;	;	:
cord-275433-58unu79x	271	23	also	also	RB
cord-275433-58unu79x	271	24	known	know	VBN
cord-275433-58unu79x	271	25	as	as	IN
cord-275433-58unu79x	271	26	SDF1α	SDF1α	NNP
cord-275433-58unu79x	271	27	)	)	-RRB-
cord-275433-58unu79x	271	28	,	,	,
cord-275433-58unu79x	271	29	induces	induce	VBZ
cord-275433-58unu79x	271	30	lymphocyte	lymphocyte	NN
cord-275433-58unu79x	271	31	activation	activation	NN
cord-275433-58unu79x	271	32	and	and	CC
cord-275433-58unu79x	271	33	homing	homing	NN
cord-275433-58unu79x	271	34	rather	rather	RB
cord-275433-58unu79x	271	35	than	than	IN
cord-275433-58unu79x	271	36	cell	cell	NN
cord-275433-58unu79x	271	37	death	death	NN
cord-275433-58unu79x	271	38	,	,	,
cord-275433-58unu79x	271	39	indicating	indicate	VBG
cord-275433-58unu79x	271	40	divergent	divergent	JJ
cord-275433-58unu79x	271	41	outcomes	outcome	NNS
cord-275433-58unu79x	271	42	in	in	IN
cord-275433-58unu79x	271	43	T	t	NN
cord-275433-58unu79x	271	44	-	-	HYPH
cord-275433-58unu79x	271	45	cell	cell	NN
cord-275433-58unu79x	271	46	physiology	physiology	NN
cord-275433-58unu79x	271	47	in	in	IN
cord-275433-58unu79x	271	48	response	response	NN
cord-275433-58unu79x	271	49	to	to	IN
cord-275433-58unu79x	271	50	engagement	engagement	NN
cord-275433-58unu79x	271	51	of	of	IN
cord-275433-58unu79x	271	52	the	the	DT
cord-275433-58unu79x	271	53	same	same	JJ
cord-275433-58unu79x	271	54	cellular	cellular	JJ
cord-275433-58unu79x	271	55	chemokine	chemokine	NN
cord-275433-58unu79x	271	56	receptor	receptor	NN
cord-275433-58unu79x	271	57	by	by	IN
cord-275433-58unu79x	271	58	a	a	DT
cord-275433-58unu79x	271	59	viral	viral	JJ
cord-275433-58unu79x	271	60	glycoprotein	glycoprotein	NN
cord-275433-58unu79x	271	61	versus	versus	IN
cord-275433-58unu79x	271	62	its	-PRON-	PRP$
cord-275433-58unu79x	271	63	endogenous	endogenous	JJ
cord-275433-58unu79x	271	64	ligand	ligand	NN
cord-275433-58unu79x	271	65	.	.	.
cord-275433-58unu79x	272	1	Future	future	JJ
cord-275433-58unu79x	272	2	studies	study	NNS
cord-275433-58unu79x	272	3	are	be	VBP
cord-275433-58unu79x	272	4	needed	need	VBN
cord-275433-58unu79x	272	5	to	to	TO
cord-275433-58unu79x	272	6	determine	determine	VB
cord-275433-58unu79x	272	7	the	the	DT
cord-275433-58unu79x	272	8	role	role	NN
cord-275433-58unu79x	272	9	of	of	IN
cord-275433-58unu79x	272	10	this	this	DT
cord-275433-58unu79x	272	11	phenomenon	phenomenon	NN
cord-275433-58unu79x	272	12	in	in	IN
cord-275433-58unu79x	272	13	CD4	CD4	NNP
cord-275433-58unu79x	272	14	+	+	CC
cord-275433-58unu79x	272	15	T	t	NN
cord-275433-58unu79x	272	16	-	-	HYPH
cord-275433-58unu79x	272	17	cell	cell	NN
cord-275433-58unu79x	272	18	depletion	depletion	NN
cord-275433-58unu79x	272	19	in	in	IN
cord-275433-58unu79x	272	20	patients	patient	NNS
cord-275433-58unu79x	272	21	with	with	IN
cord-275433-58unu79x	272	22	AIDS	AIDS	NNP
cord-275433-58unu79x	272	23	and	and	CC
cord-275433-58unu79x	272	24	to	to	TO
cord-275433-58unu79x	272	25	better	better	RB
cord-275433-58unu79x	272	26	define	define	VB
cord-275433-58unu79x	272	27	the	the	DT
cord-275433-58unu79x	272	28	factors	factor	NNS
cord-275433-58unu79x	272	29	that	that	WDT
cord-275433-58unu79x	272	30	regulate	regulate	VBP
cord-275433-58unu79x	272	31	whether	whether	IN
cord-275433-58unu79x	272	32	autophagy	autophagy	NN
cord-275433-58unu79x	272	33	has	have	VBZ
cord-275433-58unu79x	272	34	a	a	DT
cord-275433-58unu79x	272	35	pro	pro	JJ
cord-275433-58unu79x	272	36	-	-	JJ
cord-275433-58unu79x	272	37	survival	survival	JJ
cord-275433-58unu79x	272	38	or	or	CC
cord-275433-58unu79x	272	39	pro	pro	JJ
cord-275433-58unu79x	272	40	-	-	JJ
cord-275433-58unu79x	272	41	death	death	JJ
cord-275433-58unu79x	272	42	role	role	NN
cord-275433-58unu79x	272	43	in	in	IN
cord-275433-58unu79x	272	44	lymphocytes	lymphocyte	NNS
cord-275433-58unu79x	272	45	.	.	.
cord-275433-58unu79x	273	1	Given	give	VBN
cord-275433-58unu79x	273	2	the	the	DT
cord-275433-58unu79x	273	3	extensive	extensive	JJ
cord-275433-58unu79x	273	4	molecular	molecular	JJ
cord-275433-58unu79x	273	5	interplay	interplay	NN
cord-275433-58unu79x	273	6	between	between	IN
cord-275433-58unu79x	273	7	autophagy	autophagy	NN
cord-275433-58unu79x	273	8	and	and	CC
cord-275433-58unu79x	273	9	apoptosis	apoptosis	NN
cord-275433-58unu79x	273	10	88	88	CD
cord-275433-58unu79x	273	11	,	,	,
cord-275433-58unu79x	273	12	it	-PRON-	PRP
cord-275433-58unu79x	273	13	is	be	VBZ
cord-275433-58unu79x	273	14	not	not	RB
cord-275433-58unu79x	273	15	surprising	surprising	JJ
cord-275433-58unu79x	273	16	that	that	IN
cord-275433-58unu79x	273	17	autophagy	autophagy	NN
cord-275433-58unu79x	273	18	might	may	MD
cord-275433-58unu79x	273	19	have	have	VB
cord-275433-58unu79x	273	20	a	a	DT
cord-275433-58unu79x	273	21	dual	dual	JJ
cord-275433-58unu79x	273	22	role	role	NN
cord-275433-58unu79x	273	23	in	in	IN
cord-275433-58unu79x	273	24	T	t	NN
cord-275433-58unu79x	273	25	-	-	HYPH
cord-275433-58unu79x	273	26	cell	cell	NN
cord-275433-58unu79x	273	27	homeostasis	homeostasis	NN
cord-275433-58unu79x	273	28	,	,	,
cord-275433-58unu79x	273	29	executing	execute	VBG
cord-275433-58unu79x	273	30	both	both	CC
cord-275433-58unu79x	273	31	life	life	NN
cord-275433-58unu79x	273	32	and	and	CC
cord-275433-58unu79x	273	33	death	death	NN
cord-275433-58unu79x	273	34	decisions	decision	NNS
cord-275433-58unu79x	273	35	.	.	.
cord-275433-58unu79x	274	1	Furthermore	furthermore	RB
cord-275433-58unu79x	274	2	,	,	,
cord-275433-58unu79x	274	3	there	there	EX
cord-275433-58unu79x	274	4	is	be	VBZ
cord-275433-58unu79x	274	5	no	no	DT
cord-275433-58unu79x	274	6	reason	reason	NN
cord-275433-58unu79x	274	7	to	to	TO
cord-275433-58unu79x	274	8	think	think	VB
cord-275433-58unu79x	274	9	that	that	IN
cord-275433-58unu79x	274	10	the	the	DT
cord-275433-58unu79x	274	11	homeostatic	homeostatic	JJ
cord-275433-58unu79x	274	12	role	role	NN
cord-275433-58unu79x	274	13	of	of	IN
cord-275433-58unu79x	274	14	autophagy	autophagy	NN
cord-275433-58unu79x	274	15	will	will	MD
cord-275433-58unu79x	274	16	be	be	VB
cord-275433-58unu79x	274	17	confined	confine	VBN
cord-275433-58unu79x	274	18	to	to	IN
cord-275433-58unu79x	274	19	T	t	NN
cord-275433-58unu79x	274	20	cells	cell	NNS
cord-275433-58unu79x	274	21	;	;	:
cord-275433-58unu79x	274	22	as	as	IN
cord-275433-58unu79x	274	23	research	research	NN
cord-275433-58unu79x	274	24	in	in	IN
cord-275433-58unu79x	274	25	the	the	DT
cord-275433-58unu79x	274	26	field	field	NN
cord-275433-58unu79x	274	27	progresses	progress	VBZ
cord-275433-58unu79x	274	28	,	,	,
cord-275433-58unu79x	274	29	we	-PRON-	PRP
cord-275433-58unu79x	274	30	are	be	VBP
cord-275433-58unu79x	274	31	likely	likely	JJ
cord-275433-58unu79x	274	32	to	to	TO
cord-275433-58unu79x	274	33	witness	witness	VB
cord-275433-58unu79x	274	34	the	the	DT
cord-275433-58unu79x	274	35	unfolding	unfolding	NN
cord-275433-58unu79x	274	36	of	of	IN
cord-275433-58unu79x	274	37	crucial	crucial	JJ
cord-275433-58unu79x	274	38	roles	role	NNS
cord-275433-58unu79x	274	39	for	for	IN
cord-275433-58unu79x	274	40	autophagy	autophagy	NN
cord-275433-58unu79x	274	41	in	in	IN
cord-275433-58unu79x	274	42	maintaining	maintain	VBG
cord-275433-58unu79x	274	43	not	not	RB
cord-275433-58unu79x	274	44	only	only	RB
cord-275433-58unu79x	274	45	homeostasis	homeostasis	NN
cord-275433-58unu79x	274	46	but	but	CC
cord-275433-58unu79x	274	47	also	also	RB
cord-275433-58unu79x	274	48	proper	proper	JJ
cord-275433-58unu79x	274	49	differentiation	differentiation	NN
cord-275433-58unu79x	274	50	and	and	CC
cord-275433-58unu79x	274	51	function	function	NN
cord-275433-58unu79x	274	52	of	of	IN
cord-275433-58unu79x	274	53	other	other	JJ
cord-275433-58unu79x	274	54	populations	population	NNS
cord-275433-58unu79x	274	55	of	of	IN
cord-275433-58unu79x	274	56	immune	immune	JJ
cord-275433-58unu79x	274	57	cells	cell	NNS
cord-275433-58unu79x	274	58	.	.	.
cord-275433-58unu79x	275	1	An	an	DT
cord-275433-58unu79x	275	2	unexpected	unexpected	JJ
cord-275433-58unu79x	275	3	link	link	NN
cord-275433-58unu79x	275	4	between	between	IN
cord-275433-58unu79x	275	5	autophagy	autophagy	NN
cord-275433-58unu79x	275	6	and	and	CC
cord-275433-58unu79x	275	7	the	the	DT
cord-275433-58unu79x	275	8	removal	removal	NN
cord-275433-58unu79x	275	9	of	of	IN
cord-275433-58unu79x	275	10	apoptotic	apoptotic	JJ
cord-275433-58unu79x	275	11	cell	cell	NN
cord-275433-58unu79x	275	12	corpses	corpse	NNS
cord-275433-58unu79x	275	13	has	have	VBZ
cord-275433-58unu79x	275	14	recently	recently	RB
cord-275433-58unu79x	275	15	been	be	VBN
cord-275433-58unu79x	275	16	reported	report	VBN
cord-275433-58unu79x	275	17	15	15	CD
cord-275433-58unu79x	275	18	,	,	,
cord-275433-58unu79x	275	19	which	which	WDT
cord-275433-58unu79x	275	20	raises	raise	VBZ
cord-275433-58unu79x	275	21	some	some	DT
cord-275433-58unu79x	275	22	intriguing	intriguing	JJ
cord-275433-58unu79x	275	23	possibilities	possibility	NNS
cord-275433-58unu79x	275	24	about	about	IN
cord-275433-58unu79x	275	25	a	a	DT
cord-275433-58unu79x	275	26	role	role	NN
cord-275433-58unu79x	275	27	for	for	IN
cord-275433-58unu79x	275	28	autophagy	autophagy	NN
cord-275433-58unu79x	275	29	in	in	IN
cord-275433-58unu79x	275	30	the	the	DT
cord-275433-58unu79x	275	31	prevention	prevention	NN
cord-275433-58unu79x	275	32	of	of	IN
cord-275433-58unu79x	275	33	inflammation	inflammation	NN
cord-275433-58unu79x	275	34	and	and	CC
cord-275433-58unu79x	275	35	autoimmunity	autoimmunity	NN
cord-275433-58unu79x	275	36	.	.	.
cord-275433-58unu79x	276	1	Qu	Qu	NNP
cord-275433-58unu79x	276	2	et	et	NNP
cord-275433-58unu79x	276	3	al	al	NNP
cord-275433-58unu79x	276	4	.	.	.
cord-275433-58unu79x	277	1	found	find	VBD
cord-275433-58unu79x	277	2	that	that	IN
cord-275433-58unu79x	277	3	autophagy	autophagy	NN
cord-275433-58unu79x	277	4	provides	provide	VBZ
cord-275433-58unu79x	277	5	apoptotic	apoptotic	JJ
cord-275433-58unu79x	277	6	cells	cell	NNS
cord-275433-58unu79x	277	7	with	with	IN
cord-275433-58unu79x	277	8	signals	signal	NNS
cord-275433-58unu79x	277	9	to	to	TO
cord-275433-58unu79x	277	10	ensure	ensure	VB
cord-275433-58unu79x	277	11	their	-PRON-	PRP$
cord-275433-58unu79x	277	12	clearance	clearance	NN
cord-275433-58unu79x	277	13	during	during	IN
cord-275433-58unu79x	277	14	programmed	programmed	JJ
cord-275433-58unu79x	277	15	cell	cell	NN
cord-275433-58unu79x	277	16	death	death	NN
cord-275433-58unu79x	277	17	15	15	CD
cord-275433-58unu79x	277	18	.	.	.
cord-275433-58unu79x	278	1	It	-PRON-	PRP
cord-275433-58unu79x	278	2	is	be	VBZ
cord-275433-58unu79x	278	3	well	well	RB
cord-275433-58unu79x	278	4	established	establish	VBN
cord-275433-58unu79x	278	5	that	that	IN
cord-275433-58unu79x	278	6	the	the	DT
cord-275433-58unu79x	278	7	rapid	rapid	JJ
cord-275433-58unu79x	278	8	removal	removal	NN
cord-275433-58unu79x	278	9	of	of	IN
cord-275433-58unu79x	278	10	apoptotic	apoptotic	JJ
cord-275433-58unu79x	278	11	cell	cell	NN
cord-275433-58unu79x	278	12	corpses	corpse	NNS
cord-275433-58unu79x	278	13	is	be	VBZ
cord-275433-58unu79x	278	14	crucial	crucial	JJ
cord-275433-58unu79x	278	15	for	for	IN
cord-275433-58unu79x	278	16	the	the	DT
cord-275433-58unu79x	278	17	prevention	prevention	NN
cord-275433-58unu79x	278	18	of	of	IN
cord-275433-58unu79x	278	19	tissue	tissue	NN
cord-275433-58unu79x	278	20	inflammation	inflammation	NN
cord-275433-58unu79x	278	21	91	91	CD
cord-275433-58unu79x	278	22	,	,	,
cord-275433-58unu79x	278	23	and	and	CC
cord-275433-58unu79x	279	1	indeed	indeed	RB
cord-275433-58unu79x	279	2	,	,	,
cord-275433-58unu79x	279	3	autophagy	autophagy	NN
cord-275433-58unu79x	279	4	-	-	HYPH
cord-275433-58unu79x	279	5	deficient	deficient	JJ
cord-275433-58unu79x	279	6	Atg5	Atg5	NNP
cord-275433-58unu79x	279	7	-/embryos	-/embryos	:
cord-275433-58unu79x	279	8	have	have	VBP
cord-275433-58unu79x	279	9	increased	increase	VBN
cord-275433-58unu79x	279	10	inflammation	inflammation	NN
cord-275433-58unu79x	279	11	in	in	IN
cord-275433-58unu79x	279	12	tissues	tissue	NNS
cord-275433-58unu79x	279	13	that	that	WDT
cord-275433-58unu79x	279	14	have	have	VBP
cord-275433-58unu79x	279	15	impaired	impair	VBN
cord-275433-58unu79x	279	16	clearance	clearance	NN
cord-275433-58unu79x	279	17	of	of	IN
cord-275433-58unu79x	279	18	apoptotic	apoptotic	JJ
cord-275433-58unu79x	279	19	cells	cell	NNS
cord-275433-58unu79x	279	20	15	15	CD
cord-275433-58unu79x	279	21	.	.	.
cord-275433-58unu79x	280	1	Moreover	moreover	RB
cord-275433-58unu79x	280	2	,	,	,
cord-275433-58unu79x	280	3	it	-PRON-	PRP
cord-275433-58unu79x	280	4	is	be	VBZ
cord-275433-58unu79x	280	5	now	now	RB
cord-275433-58unu79x	280	6	believed	believe	VBN
cord-275433-58unu79x	280	7	that	that	IN
cord-275433-58unu79x	280	8	defective	defective	JJ
cord-275433-58unu79x	280	9	clearance	clearance	NN
cord-275433-58unu79x	280	10	of	of	IN
cord-275433-58unu79x	280	11	apoptotic	apoptotic	JJ
cord-275433-58unu79x	280	12	cells	cell	NNS
cord-275433-58unu79x	280	13	overcomes	overcome	VBZ
cord-275433-58unu79x	280	14	tolerance	tolerance	NN
cord-275433-58unu79x	280	15	to	to	IN
cord-275433-58unu79x	280	16	self	self	NN
cord-275433-58unu79x	280	17	antigens	antigen	NNS
cord-275433-58unu79x	280	18	and	and	CC
cord-275433-58unu79x	280	19	leads	lead	VBZ
cord-275433-58unu79x	280	20	to	to	IN
cord-275433-58unu79x	280	21	autoimmune	autoimmune	JJ
cord-275433-58unu79x	280	22	diseases	disease	NNS
cord-275433-58unu79x	280	23	such	such	JJ
cord-275433-58unu79x	280	24	as	as	IN
cord-275433-58unu79x	280	25	systemic	systemic	JJ
cord-275433-58unu79x	280	26	lupus	lupus	NN
cord-275433-58unu79x	280	27	erythematosus	erythematosus	NN
cord-275433-58unu79x	280	28	(	(	-LRB-
cord-275433-58unu79x	280	29	SLe	sle	NN
cord-275433-58unu79x	280	30	)	)	-RRB-
cord-275433-58unu79x	280	31	92	92	CD
cord-275433-58unu79x	280	32	,	,	,
cord-275433-58unu79x	280	33	93	93	CD
cord-275433-58unu79x	280	34	.	.	.
cord-275433-58unu79x	281	1	So	so	RB
cord-275433-58unu79x	281	2	,	,	,
cord-275433-58unu79x	281	3	it	-PRON-	PRP
cord-275433-58unu79x	281	4	is	be	VBZ
cord-275433-58unu79x	281	5	also	also	RB
cord-275433-58unu79x	281	6	possible	possible	JJ
cord-275433-58unu79x	281	7	that	that	IN
cord-275433-58unu79x	281	8	defective	defective	JJ
cord-275433-58unu79x	281	9	autophagy	autophagy	NN
cord-275433-58unu79x	281	10	may	may	MD
cord-275433-58unu79x	281	11	contribute	contribute	VB
cord-275433-58unu79x	281	12	to	to	IN
cord-275433-58unu79x	281	13	the	the	DT
cord-275433-58unu79x	281	14	pathogenesis	pathogenesis	NN
cord-275433-58unu79x	281	15	of	of	IN
cord-275433-58unu79x	281	16	SLe	sle	NN
cord-275433-58unu79x	281	17	or	or	CC
cord-275433-58unu79x	281	18	other	other	JJ
cord-275433-58unu79x	281	19	autoimmune	autoimmune	JJ
cord-275433-58unu79x	281	20	diseases	disease	NNS
cord-275433-58unu79x	281	21	.	.	.
cord-275433-58unu79x	282	1	Of	of	IN
cord-275433-58unu79x	282	2	great	great	JJ
cord-275433-58unu79x	282	3	interest	interest	NN
cord-275433-58unu79x	282	4	,	,	,
cord-275433-58unu79x	282	5	a	a	DT
cord-275433-58unu79x	282	6	strong	strong	JJ
cord-275433-58unu79x	282	7	genetic	genetic	JJ
cord-275433-58unu79x	282	8	link	link	NN
cord-275433-58unu79x	282	9	has	have	VBZ
cord-275433-58unu79x	282	10	recently	recently	RB
cord-275433-58unu79x	282	11	been	be	VBN
cord-275433-58unu79x	282	12	uncovered	uncover	VBN
cord-275433-58unu79x	282	13	between	between	IN
cord-275433-58unu79x	282	14	autophagy	autophagy	NN
cord-275433-58unu79x	282	15	and	and	CC
cord-275433-58unu79x	282	16	Crohn	Crohn	NNP
cord-275433-58unu79x	282	17	's	's	POS
cord-275433-58unu79x	282	18	disease	disease	NN
cord-275433-58unu79x	282	19	,	,	,
cord-275433-58unu79x	282	20	a	a	DT
cord-275433-58unu79x	282	21	chronic	chronic	JJ
cord-275433-58unu79x	282	22	inflammatory	inflammatory	JJ
cord-275433-58unu79x	282	23	disease	disease	NN
cord-275433-58unu79x	282	24	of	of	IN
cord-275433-58unu79x	282	25	the	the	DT
cord-275433-58unu79x	282	26	intestine	intestine	NN
cord-275433-58unu79x	282	27	.	.	.
cord-275433-58unu79x	283	1	Several	several	JJ
cord-275433-58unu79x	283	2	recent	recent	JJ
cord-275433-58unu79x	283	3	genome	genome	NN
cord-275433-58unu79x	283	4	-	-	HYPH
cord-275433-58unu79x	283	5	wide	wide	JJ
cord-275433-58unu79x	283	6	scans	scan	NNS
cord-275433-58unu79x	283	7	have	have	VBP
cord-275433-58unu79x	283	8	identified	identify	VBN
cord-275433-58unu79x	283	9	a	a	DT
cord-275433-58unu79x	283	10	strong	strong	JJ
cord-275433-58unu79x	283	11	association	association	NN
cord-275433-58unu79x	283	12	between	between	IN
cord-275433-58unu79x	283	13	a	a	DT
cord-275433-58unu79x	283	14	non	non	JJ
cord-275433-58unu79x	283	15	-	-	JJ
cord-275433-58unu79x	283	16	synonymous	synonymous	JJ
cord-275433-58unu79x	283	17	single	single	JJ
cord-275433-58unu79x	283	18	-	-	HYPH
cord-275433-58unu79x	283	19	nucleotide	nucleotide	JJ
cord-275433-58unu79x	283	20	polymorphism	polymorphism	NN
cord-275433-58unu79x	283	21	(	(	-LRB-
cord-275433-58unu79x	283	22	SNP	SNP	NNP
cord-275433-58unu79x	283	23	)	)	-RRB-
cord-275433-58unu79x	283	24	in	in	IN
cord-275433-58unu79x	283	25	the	the	DT
cord-275433-58unu79x	283	26	autophagy	autophagy	NN
cord-275433-58unu79x	283	27	gene	gene	NN
cord-275433-58unu79x	283	28	ATG16L1	ATG16L1	NNP
cord-275433-58unu79x	283	29	(	(	-LRB-
cord-275433-58unu79x	283	30	T300A	T300A	NNP
cord-275433-58unu79x	283	31	variant	variant	NN
cord-275433-58unu79x	283	32	)	)	-RRB-
cord-275433-58unu79x	283	33	and	and	CC
cord-275433-58unu79x	283	34	susceptibility	susceptibility	NN
cord-275433-58unu79x	283	35	to	to	IN
cord-275433-58unu79x	283	36	Crohn	Crohn	NNP
cord-275433-58unu79x	283	37	's	's	POS
cord-275433-58unu79x	283	38	disease	disease	NN
cord-275433-58unu79x	283	39	[	[	-LRB-
cord-275433-58unu79x	283	40	16	16	CD
cord-275433-58unu79x	283	41	]	]	-RRB-
cord-275433-58unu79x	283	42	[	[	-LRB-
cord-275433-58unu79x	283	43	17	17	CD
cord-275433-58unu79x	283	44	]	]	-RRB-
cord-275433-58unu79x	283	45	[	[	-LRB-
cord-275433-58unu79x	283	46	18	18	CD
cord-275433-58unu79x	283	47	]	]	-RRB-
cord-275433-58unu79x	283	48	[	[	-LRB-
cord-275433-58unu79x	283	49	19	19	CD
cord-275433-58unu79x	283	50	]	]	-RRB-
cord-275433-58unu79x	283	51	.	.	.
cord-275433-58unu79x	284	1	In	in	IN
cord-275433-58unu79x	284	2	addition	addition	NN
cord-275433-58unu79x	284	3	,	,	,
cord-275433-58unu79x	284	4	the	the	DT
cord-275433-58unu79x	284	5	gene	gene	NN
cord-275433-58unu79x	284	6	encoding	encode	VBG
cord-275433-58unu79x	284	7	the	the	DT
cord-275433-58unu79x	284	8	autophagy	autophagy	NN
cord-275433-58unu79x	284	9	-	-	HYPH
cord-275433-58unu79x	284	10	stimulatory	stimulatory	JJ
cord-275433-58unu79x	284	11	GTPase	GTPase	NNP
cord-275433-58unu79x	284	12	IRGM	IRGM	NNP
cord-275433-58unu79x	284	13	has	have	VBZ
cord-275433-58unu79x	284	14	been	be	VBN
cord-275433-58unu79x	284	15	identified	identify	VBN
cord-275433-58unu79x	284	16	as	as	IN
cord-275433-58unu79x	284	17	a	a	DT
cord-275433-58unu79x	284	18	susceptibility	susceptibility	NN
cord-275433-58unu79x	284	19	gene	gene	NN
cord-275433-58unu79x	284	20	for	for	IN
cord-275433-58unu79x	284	21	Crohn	Crohn	NNP
cord-275433-58unu79x	284	22	's	's	POS
cord-275433-58unu79x	284	23	disease	disease	NN
cord-275433-58unu79x	284	24	20	20	CD
cord-275433-58unu79x	284	25	.	.	.
cord-275433-58unu79x	285	1	Together	together	RB
cord-275433-58unu79x	285	2	,	,	,
cord-275433-58unu79x	285	3	these	these	DT
cord-275433-58unu79x	285	4	studies	study	NNS
cord-275433-58unu79x	285	5	are	be	VBP
cord-275433-58unu79x	285	6	suggestive	suggestive	JJ
cord-275433-58unu79x	285	7	of	of	IN
cord-275433-58unu79x	285	8	a	a	DT
cord-275433-58unu79x	285	9	role	role	NN
cord-275433-58unu79x	285	10	for	for	IN
cord-275433-58unu79x	285	11	autophagy	autophagy	NN
cord-275433-58unu79x	285	12	dysregulation	dysregulation	NN
cord-275433-58unu79x	285	13	in	in	IN
cord-275433-58unu79x	285	14	the	the	DT
cord-275433-58unu79x	285	15	pathogenesis	pathogenesis	NN
cord-275433-58unu79x	285	16	of	of	IN
cord-275433-58unu79x	285	17	Crohn	Crohn	NNP
cord-275433-58unu79x	285	18	's	's	POS
cord-275433-58unu79x	285	19	disease	disease	NN
cord-275433-58unu79x	285	20	.	.	.
cord-275433-58unu79x	286	1	This	this	DT
cord-275433-58unu79x	286	2	hypothesis	hypothesis	NN
cord-275433-58unu79x	286	3	will	will	MD
cord-275433-58unu79x	286	4	be	be	VB
cord-275433-58unu79x	286	5	strengthened	strengthen	VBN
cord-275433-58unu79x	286	6	if	if	IN
cord-275433-58unu79x	286	7	the	the	DT
cord-275433-58unu79x	286	8	ATG16L1	atg16l1	JJ
cord-275433-58unu79x	286	9	variant	variant	NN
cord-275433-58unu79x	286	10	(	(	-LRB-
cord-275433-58unu79x	286	11	T300A	T300A	NNP
cord-275433-58unu79x	286	12	)	)	-RRB-
cord-275433-58unu79x	286	13	associated	associate	VBN
cord-275433-58unu79x	286	14	with	with	IN
cord-275433-58unu79x	286	15	Crohn	Crohn	NNP
cord-275433-58unu79x	286	16	's	's	POS
cord-275433-58unu79x	286	17	disease	disease	NN
cord-275433-58unu79x	286	18	is	be	VBZ
cord-275433-58unu79x	286	19	found	find	VBN
cord-275433-58unu79x	286	20	to	to	TO
cord-275433-58unu79x	286	21	lead	lead	VB
cord-275433-58unu79x	286	22	to	to	IN
cord-275433-58unu79x	286	23	defective	defective	JJ
cord-275433-58unu79x	286	24	autophagy	autophagy	NN
cord-275433-58unu79x	286	25	function	function	NN
cord-275433-58unu79x	286	26	.	.	.
cord-275433-58unu79x	287	1	It	-PRON-	PRP
cord-275433-58unu79x	287	2	is	be	VBZ
cord-275433-58unu79x	287	3	not	not	RB
cord-275433-58unu79x	287	4	yet	yet	RB
cord-275433-58unu79x	287	5	known	know	VBN
cord-275433-58unu79x	287	6	how	how	WRB
cord-275433-58unu79x	287	7	autophagy	autophagy	NN
cord-275433-58unu79x	287	8	might	may	MD
cord-275433-58unu79x	287	9	be	be	VB
cord-275433-58unu79x	287	10	mechanistically	mechanistically	RB
cord-275433-58unu79x	287	11	linked	link	VBN
cord-275433-58unu79x	287	12	to	to	IN
cord-275433-58unu79x	287	13	susceptibility	susceptibility	NN
cord-275433-58unu79x	287	14	to	to	IN
cord-275433-58unu79x	287	15	Crohn	Crohn	NNP
cord-275433-58unu79x	287	16	's	's	POS
cord-275433-58unu79x	287	17	disease	disease	NN
cord-275433-58unu79x	287	18	.	.	.
cord-275433-58unu79x	288	1	The	the	DT
cord-275433-58unu79x	288	2	pathogenic	pathogenic	JJ
cord-275433-58unu79x	288	3	mechanisms	mechanism	NNS
cord-275433-58unu79x	288	4	of	of	IN
cord-275433-58unu79x	288	5	Crohn	Crohn	NNP
cord-275433-58unu79x	288	6	's	's	POS
cord-275433-58unu79x	288	7	disease	disease	NN
cord-275433-58unu79x	288	8	are	be	VBP
cord-275433-58unu79x	288	9	poorly	poorly	RB
cord-275433-58unu79x	288	10	understood	understand	VBN
cord-275433-58unu79x	288	11	but	but	CC
cord-275433-58unu79x	288	12	are	be	VBP
cord-275433-58unu79x	288	13	speculated	speculate	VBN
cord-275433-58unu79x	288	14	to	to	TO
cord-275433-58unu79x	288	15	involve	involve	VB
cord-275433-58unu79x	288	16	a	a	DT
cord-275433-58unu79x	288	17	dysregulated	dysregulate	VBN
cord-275433-58unu79x	288	18	immune	immune	JJ
cord-275433-58unu79x	288	19	response	response	NN
cord-275433-58unu79x	288	20	to	to	IN
cord-275433-58unu79x	288	21	commensal	commensal	JJ
cord-275433-58unu79x	288	22	gut	gut	NN
cord-275433-58unu79x	288	23	bacteria	bacteria	NNS
cord-275433-58unu79x	288	24	and	and	CC
cord-275433-58unu79x	288	25	possibly	possibly	RB
cord-275433-58unu79x	288	26	defects	defect	NNS
cord-275433-58unu79x	288	27	in	in	IN
cord-275433-58unu79x	288	28	mucosal	mucosal	JJ
cord-275433-58unu79x	288	29	barrier	barrier	NN
cord-275433-58unu79x	288	30	function	function	NN
cord-275433-58unu79x	288	31	or	or	CC
cord-275433-58unu79x	288	32	bacterial	bacterial	JJ
cord-275433-58unu79x	288	33	clearance	clearance	NN
cord-275433-58unu79x	288	34	94	94	CD
cord-275433-58unu79x	288	35	,	,	,
cord-275433-58unu79x	288	36	95	95	CD
cord-275433-58unu79x	288	37	.	.	.
cord-275433-58unu79x	289	1	It	-PRON-	PRP
cord-275433-58unu79x	289	2	is	be	VBZ
cord-275433-58unu79x	289	3	therefore	therefore	RB
cord-275433-58unu79x	289	4	possible	possible	JJ
cord-275433-58unu79x	289	5	that	that	IN
cord-275433-58unu79x	289	6	defects	defect	NNS
cord-275433-58unu79x	289	7	in	in	IN
cord-275433-58unu79x	289	8	autophagy	autophagy	NN
cord-275433-58unu79x	289	9	lead	lead	NN
cord-275433-58unu79x	289	10	to	to	IN
cord-275433-58unu79x	289	11	altered	alter	VBN
cord-275433-58unu79x	289	12	clearance	clearance	NN
cord-275433-58unu79x	289	13	of	of	IN
cord-275433-58unu79x	289	14	and/or	and/or	CC
cord-275433-58unu79x	289	15	altered	alter	VBN
cord-275433-58unu79x	289	16	immune	immune	JJ
cord-275433-58unu79x	289	17	responses	response	NNS
cord-275433-58unu79x	289	18	to	to	IN
cord-275433-58unu79x	289	19	commensal	commensal	VB
cord-275433-58unu79x	289	20	gut	gut	NN
cord-275433-58unu79x	289	21	bacteria	bacteria	NNS
cord-275433-58unu79x	289	22	.	.	.
cord-275433-58unu79x	290	1	Given	give	VBN
cord-275433-58unu79x	290	2	the	the	DT
cord-275433-58unu79x	290	3	possible	possible	JJ
cord-275433-58unu79x	290	4	role	role	NN
cord-275433-58unu79x	290	5	of	of	IN
cord-275433-58unu79x	290	6	autophagy	autophagy	NN
cord-275433-58unu79x	290	7	in	in	IN
cord-275433-58unu79x	290	8	peripheral	peripheral	JJ
cord-275433-58unu79x	290	9	tolerance	tolerance	NN
cord-275433-58unu79x	290	10	,	,	,
cord-275433-58unu79x	290	11	another	another	DT
cord-275433-58unu79x	290	12	speculation	speculation	NN
cord-275433-58unu79x	290	13	is	be	VBZ
cord-275433-58unu79x	290	14	that	that	IN
cord-275433-58unu79x	290	15	,	,	,
cord-275433-58unu79x	290	16	in	in	IN
cord-275433-58unu79x	290	17	the	the	DT
cord-275433-58unu79x	290	18	setting	setting	NN
cord-275433-58unu79x	290	19	of	of	IN
cord-275433-58unu79x	290	20	decreased	decreased	JJ
cord-275433-58unu79x	290	21	autophagy	autophagy	NN
cord-275433-58unu79x	290	22	,	,	,
cord-275433-58unu79x	290	23	tolerance	tolerance	NN
cord-275433-58unu79x	290	24	induction	induction	NN
cord-275433-58unu79x	290	25	might	may	MD
cord-275433-58unu79x	290	26	fail	fail	VB
cord-275433-58unu79x	290	27	and	and	CC
cord-275433-58unu79x	290	28	produce	produce	VB
cord-275433-58unu79x	290	29	gut	gut	NN
cord-275433-58unu79x	290	30	-	-	HYPH
cord-275433-58unu79x	290	31	reactive	reactive	JJ
cord-275433-58unu79x	290	32	immune	immune	JJ
cord-275433-58unu79x	290	33	responses	response	NNS
cord-275433-58unu79x	290	34	.	.	.
cord-275433-58unu79x	291	1	As	as	IN
cord-275433-58unu79x	291	2	the	the	DT
cord-275433-58unu79x	291	3	intestine	intestine	NN
cord-275433-58unu79x	291	4	is	be	VBZ
cord-275433-58unu79x	291	5	a	a	DT
cord-275433-58unu79x	291	6	site	site	NN
cord-275433-58unu79x	291	7	of	of	IN
cord-275433-58unu79x	291	8	constant	constant	JJ
cord-275433-58unu79x	291	9	epithelial	epithelial	JJ
cord-275433-58unu79x	291	10	-	-	HYPH
cord-275433-58unu79x	291	11	cell	cell	NN
cord-275433-58unu79x	291	12	shedding	shedding	NN
cord-275433-58unu79x	291	13	owing	owe	VBG
cord-275433-58unu79x	291	14	to	to	IN
cord-275433-58unu79x	291	15	apoptosis	apoptosis	NN
cord-275433-58unu79x	291	16	and	and	CC
cord-275433-58unu79x	291	17	regeneration	regeneration	NN
cord-275433-58unu79x	291	18	,	,	,
cord-275433-58unu79x	291	19	defective	defective	JJ
cord-275433-58unu79x	291	20	autophagy	autophagy	NN
cord-275433-58unu79x	291	21	might	may	MD
cord-275433-58unu79x	291	22	also	also	RB
cord-275433-58unu79x	291	23	contribute	contribute	VB
cord-275433-58unu79x	291	24	to	to	IN
cord-275433-58unu79x	291	25	the	the	DT
cord-275433-58unu79x	291	26	pathogenesis	pathogenesis	NN
cord-275433-58unu79x	291	27	of	of	IN
cord-275433-58unu79x	291	28	this	this	DT
cord-275433-58unu79x	291	29	inflammatory	inflammatory	JJ
cord-275433-58unu79x	291	30	disorder	disorder	NN
cord-275433-58unu79x	291	31	by	by	IN
cord-275433-58unu79x	291	32	interfering	interfere	VBG
cord-275433-58unu79x	291	33	with	with	IN
cord-275433-58unu79x	291	34	apoptotic	apoptotic	JJ
cord-275433-58unu79x	291	35	cell	cell	NN
cord-275433-58unu79x	291	36	clearance	clearance	NN
cord-275433-58unu79x	291	37	.	.	.
cord-275433-58unu79x	292	1	Studies	study	NNS
cord-275433-58unu79x	292	2	in	in	IN
cord-275433-58unu79x	292	3	targeted	target	VBN
cord-275433-58unu79x	292	4	mutant	mutant	JJ
cord-275433-58unu79x	292	5	mice	mouse	NNS
cord-275433-58unu79x	292	6	with	with	IN
cord-275433-58unu79x	292	7	conditional	conditional	JJ
cord-275433-58unu79x	292	8	deletions	deletion	NNS
cord-275433-58unu79x	292	9	or	or	CC
cord-275433-58unu79x	292	10	mutations	mutation	NNS
cord-275433-58unu79x	292	11	of	of	IN
cord-275433-58unu79x	292	12	autophagy	autophagy	NN
cord-275433-58unu79x	292	13	genes	gene	NNS
cord-275433-58unu79x	292	14	should	should	MD
cord-275433-58unu79x	292	15	help	help	VB
cord-275433-58unu79x	292	16	to	to	TO
cord-275433-58unu79x	292	17	elucidate	elucidate	VB
cord-275433-58unu79x	292	18	the	the	DT
cord-275433-58unu79x	292	19	pathogenetic	pathogenetic	JJ
cord-275433-58unu79x	292	20	mechanisms	mechanism	NNS
cord-275433-58unu79x	292	21	of	of	IN
cord-275433-58unu79x	292	22	Crohn	Crohn	NNP
cord-275433-58unu79x	292	23	's	's	POS
cord-275433-58unu79x	292	24	disease	disease	NN
cord-275433-58unu79x	292	25	.	.	.
cord-275433-58unu79x	293	1	Autophagy	Autophagy	NNP
cord-275433-58unu79x	293	2	probably	probably	RB
cord-275433-58unu79x	293	3	originated	originate	VBD
cord-275433-58unu79x	293	4	to	to	TO
cord-275433-58unu79x	293	5	degrade	degrade	VB
cord-275433-58unu79x	293	6	cellular	cellular	JJ
cord-275433-58unu79x	293	7	constituents	constituent	NNS
cord-275433-58unu79x	293	8	,	,	,
cord-275433-58unu79x	293	9	recycle	recycle	VB
cord-275433-58unu79x	293	10	nutrients	nutrient	NNS
cord-275433-58unu79x	293	11	and	and	CC
cord-275433-58unu79x	293	12	maintain	maintain	VB
cord-275433-58unu79x	293	13	cellular	cellular	JJ
cord-275433-58unu79x	293	14	survival	survival	NN
cord-275433-58unu79x	293	15	during	during	IN
cord-275433-58unu79x	293	16	starvation	starvation	NN
cord-275433-58unu79x	293	17	.	.	.
cord-275433-58unu79x	294	1	Yet	yet	RB
cord-275433-58unu79x	294	2	perhaps	perhaps	RB
cord-275433-58unu79x	294	3	,	,	,
cord-275433-58unu79x	294	4	with	with	IN
cord-275433-58unu79x	294	5	confrontations	confrontation	NNS
cord-275433-58unu79x	294	6	between	between	IN
cord-275433-58unu79x	294	7	primitive	primitive	JJ
cord-275433-58unu79x	294	8	eukaryotes	eukaryote	NNS
cord-275433-58unu79x	294	9	such	such	JJ
cord-275433-58unu79x	294	10	as	as	IN
cord-275433-58unu79x	294	11	amoebae	amoebae	NN
cord-275433-58unu79x	294	12	and	and	CC
cord-275433-58unu79x	294	13	bacteria	bacteria	NNS
cord-275433-58unu79x	294	14	,	,	,
cord-275433-58unu79x	294	15	this	this	DT
cord-275433-58unu79x	294	16	ancient	ancient	JJ
cord-275433-58unu79x	294	17	lysosomal	lysosomal	JJ
cord-275433-58unu79x	294	18	degradation	degradation	NN
cord-275433-58unu79x	294	19	pathway	pathway	NN
cord-275433-58unu79x	294	20	evolved	evolve	VBD
cord-275433-58unu79x	294	21	and	and	CC
cord-275433-58unu79x	294	22	became	become	VBD
cord-275433-58unu79x	294	23	exquisitely	exquisitely	RB
cord-275433-58unu79x	294	24	adapted	adapt	VBN
cord-275433-58unu79x	294	25	to	to	TO
cord-275433-58unu79x	294	26	orchestrate	orchestrate	VB
cord-275433-58unu79x	294	27	a	a	DT
cord-275433-58unu79x	294	28	multipronged	multipronge	VBN
cord-275433-58unu79x	294	29	defence	defence	NN
cord-275433-58unu79x	294	30	against	against	IN
cord-275433-58unu79x	294	31	intracellular	intracellular	JJ
cord-275433-58unu79x	294	32	pathogens	pathogen	NNS
cord-275433-58unu79x	294	33	.	.	.
cord-275433-58unu79x	295	1	The	the	DT
cord-275433-58unu79x	295	2	autophagy	autophagy	NN
cord-275433-58unu79x	295	3	pathway	pathway	NN
cord-275433-58unu79x	295	4	degrades	degrade	VBZ
cord-275433-58unu79x	295	5	intracellular	intracellular	JJ
cord-275433-58unu79x	295	6	pathogens	pathogen	NNS
cord-275433-58unu79x	295	7	,	,	,
cord-275433-58unu79x	295	8	and	and	CC
cord-275433-58unu79x	295	9	delivers	deliver	VBZ
cord-275433-58unu79x	295	10	microbial	microbial	JJ
cord-275433-58unu79x	295	11	genetic	genetic	JJ
cord-275433-58unu79x	295	12	material	material	NN
cord-275433-58unu79x	295	13	and	and	CC
cord-275433-58unu79x	295	14	antigens	antigen	NNS
cord-275433-58unu79x	295	15	to	to	IN
cord-275433-58unu79x	295	16	the	the	DT
cord-275433-58unu79x	295	17	necessary	necessary	JJ
cord-275433-58unu79x	295	18	cellular	cellular	JJ
cord-275433-58unu79x	295	19	compartments	compartment	NNS
cord-275433-58unu79x	295	20	for	for	IN
cord-275433-58unu79x	295	21	activation	activation	NN
cord-275433-58unu79x	295	22	of	of	IN
cord-275433-58unu79x	295	23	innate	innate	JJ
cord-275433-58unu79x	295	24	and	and	CC
cord-275433-58unu79x	295	25	adaptive	adaptive	JJ
cord-275433-58unu79x	295	26	immunity	immunity	NN
cord-275433-58unu79x	295	27	.	.	.
cord-275433-58unu79x	296	1	In	in	IN
cord-275433-58unu79x	296	2	addition	addition	NN
cord-275433-58unu79x	296	3	to	to	IN
cord-275433-58unu79x	296	4	its	-PRON-	PRP$
cord-275433-58unu79x	296	5	role	role	NN
cord-275433-58unu79x	296	6	in	in	IN
cord-275433-58unu79x	296	7	defence	defence	NN
cord-275433-58unu79x	296	8	against	against	IN
cord-275433-58unu79x	296	9	pathogens	pathogen	NNS
cord-275433-58unu79x	296	10	,	,	,
cord-275433-58unu79x	296	11	it	-PRON-	PRP
cord-275433-58unu79x	296	12	also	also	RB
cord-275433-58unu79x	296	13	is	be	VBZ
cord-275433-58unu79x	296	14	involved	involve	VBN
cord-275433-58unu79x	296	15	in	in	IN
cord-275433-58unu79x	296	16	immune	immune	JJ
cord-275433-58unu79x	296	17	-	-	HYPH
cord-275433-58unu79x	296	18	cell	cell	NN
cord-275433-58unu79x	296	19	homeostasis	homeostasis	NN
cord-275433-58unu79x	296	20	and	and	CC
cord-275433-58unu79x	296	21	potentially	potentially	RB
cord-275433-58unu79x	296	22	,	,	,
cord-275433-58unu79x	296	23	in	in	IN
cord-275433-58unu79x	296	24	preventing	prevent	VBG
cord-275433-58unu79x	296	25	inflammation	inflammation	NN
cord-275433-58unu79x	296	26	and	and	CC
cord-275433-58unu79x	296	27	autoimmunity	autoimmunity	NN
cord-275433-58unu79x	296	28	.	.	.
cord-275433-58unu79x	297	1	The	the	DT
cord-275433-58unu79x	297	2	journey	journey	NN
cord-275433-58unu79x	297	3	forward	forward	RB
cord-275433-58unu79x	297	4	-in	-in	IN
cord-275433-58unu79x	297	5	deciphering	decipher	VBG
cord-275433-58unu79x	297	6	how	how	WRB
cord-275433-58unu79x	297	7	autophagy	autophagy	NN
cord-275433-58unu79x	297	8	executes	execute	VBZ
cord-275433-58unu79x	297	9	these	these	DT
cord-275433-58unu79x	297	10	and	and	CC
cord-275433-58unu79x	297	11	,	,	,
cord-275433-58unu79x	297	12	similarly	similarly	RB
cord-275433-58unu79x	297	13	,	,	,
cord-275433-58unu79x	297	14	other	other	JJ
cord-275433-58unu79x	297	15	not	not	RB
cord-275433-58unu79x	297	16	yet	yet	RB
cord-275433-58unu79x	297	17	identified	identify	VBN
cord-275433-58unu79x	297	18	immune	immune	JJ
cord-275433-58unu79x	297	19	functions	function	NNS
cord-275433-58unu79x	298	1	-will	-will	:
cord-275433-58unu79x	298	2	be	be	VB
cord-275433-58unu79x	298	3	an	an	DT
cord-275433-58unu79x	298	4	exciting	exciting	JJ
cord-275433-58unu79x	298	5	challenge	challenge	NN
cord-275433-58unu79x	298	6	for	for	IN
cord-275433-58unu79x	298	7	immunologists	immunologist	NNS
cord-275433-58unu79x	298	8	.	.	.
cord-275433-58unu79x	299	1	Note	note	NN
cord-275433-58unu79x	299	2	added	add	VBN
cord-275433-58unu79x	299	3	in	in	IN
cord-275433-58unu79x	299	4	proof	proof	NN
cord-275433-58unu79x	299	5	while	while	IN
cord-275433-58unu79x	299	6	this	this	DT
cord-275433-58unu79x	299	7	manuscript	manuscript	NN
cord-275433-58unu79x	299	8	was	be	VBD
cord-275433-58unu79x	299	9	in	in	IN
cord-275433-58unu79x	299	10	press	press	NN
cord-275433-58unu79x	299	11	a	a	DT
cord-275433-58unu79x	299	12	new	new	JJ
cord-275433-58unu79x	299	13	link	link	NN
cord-275433-58unu79x	299	14	was	be	VBD
cord-275433-58unu79x	299	15	reported	report	VBN
cord-275433-58unu79x	299	16	between	between	IN
cord-275433-58unu79x	299	17	pattern	pattern	NN
cord-275433-58unu79x	299	18	-	-	HYPH
cord-275433-58unu79x	299	19	recognition	recognition	NN
cord-275433-58unu79x	299	20	receptors	receptor	NNS
cord-275433-58unu79x	299	21	of	of	IN
cord-275433-58unu79x	299	22	innate	innate	JJ
cord-275433-58unu79x	299	23	immunity	immunity	NN
cord-275433-58unu79x	299	24	and	and	CC
cord-275433-58unu79x	299	25	stimulation	stimulation	NN
cord-275433-58unu79x	299	26	of	of	IN
cord-275433-58unu79x	299	27	autophagy	autophagy	NN
cord-275433-58unu79x	299	28	.	.	.
cord-275433-58unu79x	300	1	Xu	Xu	NNP
cord-275433-58unu79x	300	2	et	et	NNP
cord-275433-58unu79x	300	3	al	al	NNP
cord-275433-58unu79x	300	4	.	.	.
cord-275433-58unu79x	301	1	found	find	VBD
cord-275433-58unu79x	301	2	that	that	IN
cord-275433-58unu79x	301	3	the	the	DT
cord-275433-58unu79x	301	4	Gram	gram	NN
cord-275433-58unu79x	301	5	-	-	HYPH
cord-275433-58unu79x	301	6	negative	negative	JJ
cord-275433-58unu79x	301	7	bacterial	bacterial	JJ
cord-275433-58unu79x	301	8	lipopolysaccharide	lipopolysaccharide	NN
cord-275433-58unu79x	301	9	induces	induce	VBZ
cord-275433-58unu79x	301	10	autophagy	autophagy	NN
cord-275433-58unu79x	301	11	in	in	IN
cord-275433-58unu79x	301	12	macrophages	macrophage	NNS
cord-275433-58unu79x	301	13	through	through	IN
cord-275433-58unu79x	301	14	a	a	DT
cord-275433-58unu79x	301	15	TLR4	TLR4	NNP
cord-275433-58unu79x	301	16	signalling	signal	VBG
cord-275433-58unu79x	301	17	pathway	pathway	NN
cord-275433-58unu79x	301	18	96	96	CD
cord-275433-58unu79x	301	19	.	.	.
cord-275433-58unu79x	302	1	Autophagy	Autophagy	NNP
cord-275433-58unu79x	302	2	as	as	IN
cord-275433-58unu79x	302	3	a	a	DT
cord-275433-58unu79x	302	4	regulated	regulated	JJ
cord-275433-58unu79x	302	5	pathway	pathway	NN
cord-275433-58unu79x	302	6	of	of	IN
cord-275433-58unu79x	302	7	cellular	cellular	JJ
cord-275433-58unu79x	302	8	degradation	degradation	NN
cord-275433-58unu79x	302	9	Autophagy	Autophagy	NNP
cord-275433-58unu79x	302	10	in	in	IN
cord-275433-58unu79x	302	11	metazoans	metazoans	NNP
cord-275433-58unu79x	302	12	:	:	:
cord-275433-58unu79x	302	13	cell	cell	NN
cord-275433-58unu79x	302	14	survival	survival	NN
cord-275433-58unu79x	302	15	in	in	IN
cord-275433-58unu79x	302	16	the	the	DT
cord-275433-58unu79x	302	17	land	land	NN
cord-275433-58unu79x	302	18	of	of	IN
cord-275433-58unu79x	302	19	plenty	plenty	JJ
cord-275433-58unu79x	302	20	Development	development	NN
cord-275433-58unu79x	302	21	by	by	IN
cord-275433-58unu79x	302	22	selfdigestion	selfdigestion	NN
cord-275433-58unu79x	302	23	:	:	:
cord-275433-58unu79x	302	24	molecular	molecular	JJ
cord-275433-58unu79x	302	25	mechanisms	mechanism	NNS
cord-275433-58unu79x	302	26	and	and	CC
cord-275433-58unu79x	302	27	biological	biological	JJ
cord-275433-58unu79x	302	28	functions	function	NNS
cord-275433-58unu79x	302	29	of	of	IN
cord-275433-58unu79x	302	30	autophagy	autophagy	NN
cord-275433-58unu79x	303	1	References	reference	NNS
cord-275433-58unu79x	303	2	1	1	CD
cord-275433-58unu79x	303	3	-	-	SYM
cord-275433-58unu79x	303	4	4	4	CD
cord-275433-58unu79x	303	5	provide	provide	VB
cord-275433-58unu79x	303	6	excellent	excellent	JJ
cord-275433-58unu79x	303	7	general	general	JJ
cord-275433-58unu79x	303	8	reviews	review	NNS
cord-275433-58unu79x	303	9	on	on	IN
cord-275433-58unu79x	303	10	autophagy	autophagy	NN
cord-275433-58unu79x	303	11	and	and	CC
cord-275433-58unu79x	303	12	its	-PRON-	PRP$
cord-275433-58unu79x	303	13	molecular	molecular	JJ
cord-275433-58unu79x	303	14	mechanisms	mechanism	NNS
cord-275433-58unu79x	303	15	,	,	,
cord-275433-58unu79x	303	16	physiological	physiological	JJ
cord-275433-58unu79x	303	17	functions	function	NNS
cord-275433-58unu79x	303	18	and	and	CC
cord-275433-58unu79x	303	19	roles	role	NNS
cord-275433-58unu79x	303	20	in	in	IN
cord-275433-58unu79x	303	21	disease	disease	NN
cord-275433-58unu79x	303	22	Autophagy	Autophagy	NNP
cord-275433-58unu79x	303	23	in	in	IN
cord-275433-58unu79x	303	24	innate	innate	JJ
cord-275433-58unu79x	303	25	and	and	CC
cord-275433-58unu79x	303	26	adaptive	adaptive	JJ
cord-275433-58unu79x	303	27	immunity	immunity	NN
cord-275433-58unu79x	303	28	Autophagy	Autophagy	NNP
cord-275433-58unu79x	303	29	in	in	IN
cord-275433-58unu79x	303	30	innate	innate	JJ
cord-275433-58unu79x	303	31	and	and	CC
cord-275433-58unu79x	303	32	adaptive	adaptive	JJ
cord-275433-58unu79x	303	33	immunity	immunity	NN
cord-275433-58unu79x	303	34	against	against	IN
cord-275433-58unu79x	303	35	intracellular	intracellular	JJ
cord-275433-58unu79x	303	36	pathogens	pathogen	NNS
cord-275433-58unu79x	303	37	Autophagy	Autophagy	NNP
cord-275433-58unu79x	303	38	as	as	IN
cord-275433-58unu79x	303	39	an	an	DT
cord-275433-58unu79x	303	40	immune	immune	JJ
cord-275433-58unu79x	303	41	defense	defense	NN
cord-275433-58unu79x	303	42	mechanism	mechanism	NN
cord-275433-58unu79x	303	43	CD40	CD40	NNP
cord-275433-58unu79x	303	44	induces	induce	VBZ
cord-275433-58unu79x	303	45	macrophage	macrophage	NN
cord-275433-58unu79x	303	46	anti	anti	JJ
cord-275433-58unu79x	303	47	-	-	JJ
cord-275433-58unu79x	303	48	Toxoplasma	toxoplasma	JJ
cord-275433-58unu79x	303	49	gondii	gondii	NN
cord-275433-58unu79x	303	50	activity	activity	NN
cord-275433-58unu79x	303	51	by	by	IN
cord-275433-58unu79x	303	52	triggering	trigger	VBG
cord-275433-58unu79x	303	53	autophagy	autophagy	NN
cord-275433-58unu79x	303	54	-	-	HYPH
cord-275433-58unu79x	303	55	dependent	dependent	JJ
cord-275433-58unu79x	303	56	fusion	fusion	NN
cord-275433-58unu79x	303	57	of	of	IN
cord-275433-58unu79x	303	58	pathogencontaining	pathogencontaining	NN
cord-275433-58unu79x	303	59	vacuoles	vacuole	NNS
cord-275433-58unu79x	303	60	and	and	CC
cord-275433-58unu79x	303	61	lysosomes	lysosome	NNS
cord-275433-58unu79x	303	62	Vacuolar	Vacuolar	NNP
cord-275433-58unu79x	303	63	and	and	CC
cord-275433-58unu79x	303	64	plasma	plasma	NN
cord-275433-58unu79x	303	65	membrane	membrane	NN
cord-275433-58unu79x	303	66	stripping	strip	VBG
cord-275433-58unu79x	303	67	and	and	CC
cord-275433-58unu79x	303	68	autophagic	autophagic	JJ
cord-275433-58unu79x	303	69	elimination	elimination	NN
cord-275433-58unu79x	303	70	of	of	IN
cord-275433-58unu79x	303	71	Toxoplasma	toxoplasma	JJ
cord-275433-58unu79x	303	72	gondii	gondii	NN
cord-275433-58unu79x	303	73	in	in	IN
cord-275433-58unu79x	303	74	primed	prime	VBN
cord-275433-58unu79x	303	75	effector	effector	NN
cord-275433-58unu79x	303	76	macrophages	macrophage	NNS
cord-275433-58unu79x	303	77	Autophagy	Autophagy	NNP
cord-275433-58unu79x	303	78	in	in	IN
cord-275433-58unu79x	303	79	innate	innate	JJ
cord-275433-58unu79x	303	80	immunity	immunity	NN
cord-275433-58unu79x	303	81	against	against	IN
cord-275433-58unu79x	303	82	intracellular	intracellular	JJ
cord-275433-58unu79x	303	83	bacteria	bacteria	NNS
cord-275433-58unu79x	303	84	Autophagy	Autophagy	NNP
cord-275433-58unu79x	303	85	in	in	IN
cord-275433-58unu79x	303	86	MHC	MHC	NNP
cord-275433-58unu79x	303	87	class	class	NN
cord-275433-58unu79x	303	88	II	II	NNP
cord-275433-58unu79x	303	89	presentation	presentation	NN
cord-275433-58unu79x	303	90	:	:	:
cord-275433-58unu79x	303	91	sampling	sampling	NN
cord-275433-58unu79x	303	92	from	from	IN
cord-275433-58unu79x	303	93	within	within	IN
cord-275433-58unu79x	303	94	Autophagy	Autophagy	NNP
cord-275433-58unu79x	303	95	-	-	HYPH
cord-275433-58unu79x	303	96	dependent	dependent	JJ
cord-275433-58unu79x	303	97	viral	viral	JJ
cord-275433-58unu79x	303	98	recognition	recognition	NN
cord-275433-58unu79x	303	99	by	by	IN
cord-275433-58unu79x	303	100	plasmacytoid	plasmacytoid	NNP
cord-275433-58unu79x	303	101	dendritic	dendritic	JJ
cord-275433-58unu79x	303	102	cell	cell	NN
cord-275433-58unu79x	304	1	This	this	DT
cord-275433-58unu79x	304	2	is	be	VBZ
cord-275433-58unu79x	304	3	a	a	DT
cord-275433-58unu79x	304	4	landmark	landmark	NN
cord-275433-58unu79x	304	5	paper	paper	NN
cord-275433-58unu79x	304	6	describing	describe	VBG
cord-275433-58unu79x	304	7	a	a	DT
cord-275433-58unu79x	304	8	new	new	JJ
cord-275433-58unu79x	304	9	function	function	NN
cord-275433-58unu79x	304	10	of	of	IN
cord-275433-58unu79x	304	11	autophagy	autophagy	NN
cord-275433-58unu79x	304	12	in	in	IN
cord-275433-58unu79x	304	13	innate	innate	JJ
cord-275433-58unu79x	304	14	immunity	immunity	NN
cord-275433-58unu79x	304	15	;	;	:
cord-275433-58unu79x	304	16	this	this	DT
cord-275433-58unu79x	304	17	paper	paper	NN
cord-275433-58unu79x	304	18	provides	provide	VBZ
cord-275433-58unu79x	304	19	the	the	DT
cord-275433-58unu79x	304	20	first	first	JJ
cord-275433-58unu79x	304	21	evidence	evidence	NN
cord-275433-58unu79x	304	22	that	that	IN
cord-275433-58unu79x	304	23	the	the	DT
cord-275433-58unu79x	304	24	autophagic	autophagic	NNP
cord-275433-58unu79x	304	25	machinery	machinery	NN
cord-275433-58unu79x	304	26	delivers	deliver	VBZ
cord-275433-58unu79x	304	27	viral	viral	JJ
cord-275433-58unu79x	304	28	genetic	genetic	JJ
cord-275433-58unu79x	304	29	material	material	NN
cord-275433-58unu79x	304	30	to	to	IN
cord-275433-58unu79x	304	31	endosomal	endosomal	NNP
cord-275433-58unu79x	304	32	TLRs	TLRs	NNP
cord-275433-58unu79x	305	1	A	a	DT
cord-275433-58unu79x	305	2	critical	critical	JJ
cord-275433-58unu79x	305	3	role	role	NN
cord-275433-58unu79x	305	4	for	for	IN
cord-275433-58unu79x	305	5	the	the	DT
cord-275433-58unu79x	305	6	autophagy	autophagy	NN
cord-275433-58unu79x	305	7	gene	gene	NN
cord-275433-58unu79x	305	8	Atg5	atg5	RB
cord-275433-58unu79x	305	9	in	in	IN
cord-275433-58unu79x	305	10	T	T	NNP
cord-275433-58unu79x	305	11	cell	cell	NN
cord-275433-58unu79x	305	12	survival	survival	NN
cord-275433-58unu79x	305	13	and	and	CC
cord-275433-58unu79x	305	14	proliferation	proliferation	NN
cord-275433-58unu79x	305	15	Autophagy	Autophagy	NNP
cord-275433-58unu79x	305	16	is	be	VBZ
cord-275433-58unu79x	305	17	induced	induce	VBN
cord-275433-58unu79x	305	18	in	in	IN
cord-275433-58unu79x	305	19	CD4	CD4	NNP
cord-275433-58unu79x	305	20	+	+	CC
cord-275433-58unu79x	305	21	T	t	NN
cord-275433-58unu79x	305	22	cells	cell	NNS
cord-275433-58unu79x	305	23	and	and	CC
cord-275433-58unu79x	305	24	important	important	JJ
cord-275433-58unu79x	305	25	for	for	IN
cord-275433-58unu79x	305	26	the	the	DT
cord-275433-58unu79x	305	27	growth	growth	NN
cord-275433-58unu79x	305	28	factor	factor	NN
cord-275433-58unu79x	305	29	-	-	HYPH
cord-275433-58unu79x	305	30	withdrawal	withdrawal	NN
cord-275433-58unu79x	305	31	cell	cell	NN
cord-275433-58unu79x	305	32	death	death	NN
cord-275433-58unu79x	306	1	This	this	DT
cord-275433-58unu79x	306	2	paper	paper	NN
cord-275433-58unu79x	306	3	describes	describe	VBZ
cord-275433-58unu79x	306	4	a	a	DT
cord-275433-58unu79x	306	5	cell	cell	NN
cord-275433-58unu79x	306	6	-	-	HYPH
cord-275433-58unu79x	306	7	autonomous	autonomous	JJ
cord-275433-58unu79x	306	8	essential	essential	JJ
cord-275433-58unu79x	306	9	role	role	NN
cord-275433-58unu79x	306	10	for	for	IN
cord-275433-58unu79x	306	11	autophagy	autophagy	NN
cord-275433-58unu79x	306	12	in	in	IN
cord-275433-58unu79x	306	13	generating	generate	VBG
cord-275433-58unu79x	306	14	signals	signal	NNS
cord-275433-58unu79x	306	15	for	for	IN
cord-275433-58unu79x	306	16	apoptotic	apoptotic	JJ
cord-275433-58unu79x	306	17	cell	cell	NN
cord-275433-58unu79x	306	18	corpse	corpse	NN
cord-275433-58unu79x	306	19	removal	removal	NN
cord-275433-58unu79x	306	20	,	,	,
cord-275433-58unu79x	306	21	raising	raise	VBG
cord-275433-58unu79x	306	22	the	the	DT
cord-275433-58unu79x	306	23	possibility	possibility	NN
cord-275433-58unu79x	306	24	that	that	IN
cord-275433-58unu79x	306	25	autophagy	autophagy	NN
cord-275433-58unu79x	306	26	may	may	MD
cord-275433-58unu79x	306	27	help	help	VB
cord-275433-58unu79x	306	28	to	to	TO
cord-275433-58unu79x	306	29	prevent	prevent	VB
cord-275433-58unu79x	306	30	inflammation	inflammation	NN
cord-275433-58unu79x	306	31	and	and	CC
cord-275433-58unu79x	306	32	autoimmunity	autoimmunity	IN
cord-275433-58unu79x	306	33	A	a	DT
cord-275433-58unu79x	306	34	genome	genome	NN
cord-275433-58unu79x	306	35	-	-	HYPH
cord-275433-58unu79x	306	36	wide	wide	JJ
cord-275433-58unu79x	306	37	association	association	NN
cord-275433-58unu79x	306	38	scan	scan	NN
cord-275433-58unu79x	306	39	of	of	IN
cord-275433-58unu79x	306	40	nonsynonymous	nonsynonymous	NNP
cord-275433-58unu79x	306	41	SNPs	SNPs	NNPS
cord-275433-58unu79x	306	42	identifies	identify	VBZ
cord-275433-58unu79x	306	43	a	a	DT
cord-275433-58unu79x	306	44	susceptibility	susceptibility	NN
cord-275433-58unu79x	306	45	variant	variant	NN
cord-275433-58unu79x	306	46	for	for	IN
cord-275433-58unu79x	306	47	Crohn	Crohn	NNP
cord-275433-58unu79x	306	48	disease	disease	NN
cord-275433-58unu79x	306	49	in	in	IN
cord-275433-58unu79x	306	50	ATG16L1	ATG16L1	NNP
cord-275433-58unu79x	306	51	Genome	Genome	NNP
cord-275433-58unu79x	306	52	-	-	HYPH
cord-275433-58unu79x	306	53	wide	wide	JJ
cord-275433-58unu79x	306	54	association	association	NN
cord-275433-58unu79x	306	55	study	study	NN
cord-275433-58unu79x	306	56	identifies	identify	VBZ
cord-275433-58unu79x	306	57	new	new	JJ
cord-275433-58unu79x	306	58	susceptibility	susceptibility	NN
cord-275433-58unu79x	306	59	loci	locus	NNS
cord-275433-58unu79x	306	60	for	for	IN
cord-275433-58unu79x	306	61	Crohn	Crohn	NNP
cord-275433-58unu79x	306	62	disease	disease	NN
cord-275433-58unu79x	306	63	and	and	CC
cord-275433-58unu79x	306	64	implicates	implicate	VBZ
cord-275433-58unu79x	306	65	autophagy	autophagy	NN
cord-275433-58unu79x	306	66	in	in	IN
cord-275433-58unu79x	306	67	disease	disease	NN
cord-275433-58unu79x	306	68	pathogenesis	pathogenesis	NN
cord-275433-58unu79x	307	1	A	a	DT
cord-275433-58unu79x	307	2	nonsynonymous	nonsynonymous	JJ
cord-275433-58unu79x	307	3	SNP	SNP	NNP
cord-275433-58unu79x	307	4	in	in	IN
cord-275433-58unu79x	307	5	ATG16L	atg16l	NN
cord-275433-58unu79x	307	6	predisposes	predispose	VBZ
cord-275433-58unu79x	307	7	to	to	TO
cord-275433-58unu79x	307	8	ileal	ileal	JJ
cord-275433-58unu79x	307	9	Crohn	Crohn	NNP
cord-275433-58unu79x	307	10	's	's	POS
cord-275433-58unu79x	307	11	disease	disease	NN
cord-275433-58unu79x	307	12	and	and	CC
cord-275433-58unu79x	307	13	is	be	VBZ
cord-275433-58unu79x	307	14	independent	independent	JJ
cord-275433-58unu79x	307	15	of	of	IN
cord-275433-58unu79x	307	16	CARD15	CARD15	NNP
cord-275433-58unu79x	307	17	and	and	CC
cord-275433-58unu79x	307	18	IBD5	IBD5	NNP
cord-275433-58unu79x	307	19	The	the	DT
cord-275433-58unu79x	307	20	Wellcome	Wellcome	NNP
cord-275433-58unu79x	307	21	Trust	Trust	NNP
cord-275433-58unu79x	307	22	Case	Case	NNP
cord-275433-58unu79x	307	23	Control	Control	NNP
cord-275433-58unu79x	307	24	Consortium	Consortium	NNP
cord-275433-58unu79x	307	25	Genome	Genome	NNP
cord-275433-58unu79x	307	26	-	-	HYPH
cord-275433-58unu79x	307	27	wide	wide	JJ
cord-275433-58unu79x	307	28	association	association	NN
cord-275433-58unu79x	307	29	study	study	NN
cord-275433-58unu79x	307	30	of	of	IN
cord-275433-58unu79x	307	31	14,000	14,000	CD
cord-275433-58unu79x	307	32	cases	case	NNS
cord-275433-58unu79x	307	33	of	of	IN
cord-275433-58unu79x	307	34	seven	seven	CD
cord-275433-58unu79x	307	35	common	common	JJ
cord-275433-58unu79x	307	36	diseases	disease	NNS
cord-275433-58unu79x	307	37	and	and	CC
cord-275433-58unu79x	307	38	3,000	3,000	CD
cord-275433-58unu79x	307	39	shared	share	VBN
cord-275433-58unu79x	307	40	controls	control	NNS
cord-275433-58unu79x	308	1	References	reference	NNS
cord-275433-58unu79x	308	2	15	15	CD
cord-275433-58unu79x	308	3	-	-	SYM
cord-275433-58unu79x	308	4	20	20	CD
cord-275433-58unu79x	308	5	provide	provide	VB
cord-275433-58unu79x	308	6	the	the	DT
cord-275433-58unu79x	308	7	first	first	JJ
cord-275433-58unu79x	308	8	genetic	genetic	JJ
cord-275433-58unu79x	308	9	evidence	evidence	NN
cord-275433-58unu79x	308	10	that	that	IN
cord-275433-58unu79x	308	11	human	human	JJ
cord-275433-58unu79x	308	12	autophagy	autophagy	NN
cord-275433-58unu79x	308	13	genes	gene	NNS
cord-275433-58unu79x	308	14	are	be	VBP
cord-275433-58unu79x	308	15	linked	link	VBN
cord-275433-58unu79x	308	16	to	to	IN
cord-275433-58unu79x	308	17	susceptibility	susceptibility	NN
cord-275433-58unu79x	308	18	to	to	IN
cord-275433-58unu79x	308	19	inflammatory	inflammatory	JJ
cord-275433-58unu79x	308	20	disease	disease	NN
cord-275433-58unu79x	308	21	Regulation	regulation	NN
cord-275433-58unu79x	308	22	and	and	CC
cord-275433-58unu79x	308	23	role	role	NN
cord-275433-58unu79x	308	24	of	of	IN
cord-275433-58unu79x	308	25	autophagy	autophagy	NN
cord-275433-58unu79x	308	26	in	in	IN
cord-275433-58unu79x	308	27	mammalian	mammalian	JJ
cord-275433-58unu79x	308	28	cells	cell	NNS
cord-275433-58unu79x	309	1	References	reference	NNS
cord-275433-58unu79x	309	2	21	21	CD
cord-275433-58unu79x	309	3	-	-	SYM
cord-275433-58unu79x	309	4	22	22	CD
cord-275433-58unu79x	309	5	provide	provide	VBP
cord-275433-58unu79x	309	6	excellent	excellent	JJ
cord-275433-58unu79x	309	7	,	,	,
cord-275433-58unu79x	309	8	comprehensive	comprehensive	JJ
cord-275433-58unu79x	309	9	reviews	review	NNS
cord-275433-58unu79x	309	10	of	of	IN
cord-275433-58unu79x	309	11	the	the	DT
cord-275433-58unu79x	309	12	signalling	signal	VBG
cord-275433-58unu79x	309	13	pathways	pathway	NNS
cord-275433-58unu79x	309	14	that	that	WDT
cord-275433-58unu79x	309	15	regulate	regulate	VBP
cord-275433-58unu79x	309	16	autophagy	autophagy	NN
cord-275433-58unu79x	309	17	hVps34	hvps34	CD
cord-275433-58unu79x	310	1	is	be	VBZ
cord-275433-58unu79x	311	1	a	a	DT
cord-275433-58unu79x	311	2	nutrient	nutrient	NN
cord-275433-58unu79x	311	3	-	-	HYPH
cord-275433-58unu79x	311	4	regulated	regulate	VBN
cord-275433-58unu79x	311	5	lipid	lipid	NN
cord-275433-58unu79x	311	6	kinase	kinase	NN
cord-275433-58unu79x	311	7	required	require	VBN
cord-275433-58unu79x	311	8	for	for	IN
cord-275433-58unu79x	311	9	activation	activation	NN
cord-275433-58unu79x	311	10	of	of	IN
cord-275433-58unu79x	311	11	p70	p70	CD
cord-275433-58unu79x	311	12	S6	S6	NNP
cord-275433-58unu79x	311	13	kinase	kinase	NN
cord-275433-58unu79x	311	14	Amino	Amino	NNP
cord-275433-58unu79x	311	15	acids	acid	NNS
cord-275433-58unu79x	311	16	mediate	mediate	VBP
cord-275433-58unu79x	311	17	mTOR	mtor	NN
cord-275433-58unu79x	311	18	/	/	SYM
cord-275433-58unu79x	311	19	raptor	raptor	NN
cord-275433-58unu79x	311	20	signaling	signal	VBG
cord-275433-58unu79x	311	21	through	through	IN
cord-275433-58unu79x	311	22	activation	activation	NN
cord-275433-58unu79x	311	23	of	of	IN
cord-275433-58unu79x	311	24	class	class	NN
cord-275433-58unu79x	311	25	3	3	CD
cord-275433-58unu79x	311	26	phosphatidylinositol	phosphatidylinositol	JJ
cord-275433-58unu79x	311	27	3OH	3OH	NNP
cord-275433-58unu79x	311	28	-	-	:
cord-275433-58unu79x	311	29	kinase	kinase	VBN
cord-275433-58unu79x	311	30	Beclin	Beclin	NNP
cord-275433-58unu79x	311	31	-	-	HYPH
cord-275433-58unu79x	311	32	phosphatidylinositol	phosphatidylinositol	JJ
cord-275433-58unu79x	311	33	3-kinase	3-kinase	CD
cord-275433-58unu79x	311	34	complex	complex	JJ
cord-275433-58unu79x	311	35	functions	function	NNS
cord-275433-58unu79x	311	36	at	at	IN
cord-275433-58unu79x	311	37	the	the	DT
cord-275433-58unu79x	311	38	trans	trans	NNP
cord-275433-58unu79x	311	39	-	-	NNP
cord-275433-58unu79x	311	40	Golgi	Golgi	NNP
cord-275433-58unu79x	311	41	network	network	NN
cord-275433-58unu79x	311	42	Autophagic	Autophagic	NNP
cord-275433-58unu79x	311	43	and	and	CC
cord-275433-58unu79x	311	44	tumour	tumour	NN
cord-275433-58unu79x	311	45	suppressor	suppressor	NN
cord-275433-58unu79x	311	46	activity	activity	NN
cord-275433-58unu79x	311	47	of	of	IN
cord-275433-58unu79x	311	48	a	a	DT
cord-275433-58unu79x	311	49	novel	novel	JJ
cord-275433-58unu79x	311	50	Beclin	Beclin	NNP
cord-275433-58unu79x	311	51	1-binding	1-binding	CD
cord-275433-58unu79x	312	1	protein	protein	NN
cord-275433-58unu79x	312	2	UVRAG	UVRAG	NNP
cord-275433-58unu79x	312	3	Ambra1	Ambra1	NNP
cord-275433-58unu79x	312	4	regulates	regulate	VBZ
cord-275433-58unu79x	312	5	autophagy	autophagy	NN
cord-275433-58unu79x	312	6	and	and	CC
cord-275433-58unu79x	312	7	development	development	NN
cord-275433-58unu79x	312	8	of	of	IN
cord-275433-58unu79x	312	9	the	the	DT
cord-275433-58unu79x	312	10	nervous	nervous	JJ
cord-275433-58unu79x	312	11	system	system	NN
cord-275433-58unu79x	313	1	Bcl-2	Bcl-2	NNP
cord-275433-58unu79x	313	2	antiapoptotic	antiapoptotic	NNP
cord-275433-58unu79x	313	3	proteins	protein	NNS
cord-275433-58unu79x	313	4	inhibit	inhibit	VBP
cord-275433-58unu79x	313	5	Beclin	Beclin	NNP
cord-275433-58unu79x	314	1	1-dependent	1-dependent	CD
cord-275433-58unu79x	314	2	autophagy	autophagy	NN
cord-275433-58unu79x	314	3	TOR	TOR	NNP
cord-275433-58unu79x	314	4	signaling	signal	VBG
cord-275433-58unu79x	314	5	in	in	IN
cord-275433-58unu79x	314	6	growth	growth	NN
cord-275433-58unu79x	314	7	and	and	CC
cord-275433-58unu79x	314	8	metabolism	metabolism	NN
cord-275433-58unu79x	314	9	3-Methyladenine	3-methyladenine	CD
cord-275433-58unu79x	314	10	:	:	:
cord-275433-58unu79x	315	1	specific	specific	JJ
cord-275433-58unu79x	315	2	inhibitor	inhibitor	NN
cord-275433-58unu79x	315	3	of	of	IN
cord-275433-58unu79x	315	4	autophagic	autophagic	NNP
cord-275433-58unu79x	315	5	/	/	SYM
cord-275433-58unu79x	315	6	lysosomal	lysosomal	JJ
cord-275433-58unu79x	315	7	protein	protein	NN
cord-275433-58unu79x	315	8	degradation	degradation	NN
cord-275433-58unu79x	315	9	in	in	IN
cord-275433-58unu79x	315	10	isolated	isolate	VBN
cord-275433-58unu79x	315	11	rat	rat	NN
cord-275433-58unu79x	315	12	hepatocytes	hepatocyte	NNS
cord-275433-58unu79x	316	1	A	a	DT
cord-275433-58unu79x	316	2	unified	unified	JJ
cord-275433-58unu79x	316	3	nomenclature	nomenclature	NN
cord-275433-58unu79x	316	4	for	for	IN
cord-275433-58unu79x	316	5	yeast	yeast	NN
cord-275433-58unu79x	316	6	autophagy	autophagy	NN
cord-275433-58unu79x	316	7	-	-	HYPH
cord-275433-58unu79x	316	8	related	relate	VBN
cord-275433-58unu79x	316	9	genes	gene	NNS
cord-275433-58unu79x	316	10	Molecular	molecular	JJ
cord-275433-58unu79x	316	11	dissection	dissection	NN
cord-275433-58unu79x	316	12	of	of	IN
cord-275433-58unu79x	316	13	autophagy	autophagy	NN
cord-275433-58unu79x	316	14	:	:	:
cord-275433-58unu79x	316	15	two	two	CD
cord-275433-58unu79x	316	16	ubiquitin	ubiquitin	JJ
cord-275433-58unu79x	316	17	-	-	HYPH
cord-275433-58unu79x	316	18	like	like	JJ
cord-275433-58unu79x	316	19	systems	system	NNS
cord-275433-58unu79x	316	20	Autophagy	autophagy	NN
cord-275433-58unu79x	316	21	:	:	:
cord-275433-58unu79x	316	22	molecular	molecular	JJ
cord-275433-58unu79x	316	23	machinery	machinery	NN
cord-275433-58unu79x	316	24	for	for	IN
cord-275433-58unu79x	316	25	self	self	NN
cord-275433-58unu79x	316	26	-	-	HYPH
cord-275433-58unu79x	316	27	eating	eat	VBG
cord-275433-58unu79x	316	28	Molecular	molecular	JJ
cord-275433-58unu79x	316	29	machinery	machinery	NN
cord-275433-58unu79x	316	30	of	of	IN
cord-275433-58unu79x	316	31	autophagosome	autophagosome	JJ
cord-275433-58unu79x	316	32	formation	formation	NN
cord-275433-58unu79x	316	33	in	in	IN
cord-275433-58unu79x	316	34	yeast	yeast	NN
cord-275433-58unu79x	316	35	,	,	,
cord-275433-58unu79x	316	36	Saccharomyces	Saccharomyces	NNP
cord-275433-58unu79x	316	37	cerevisiae	cerevisiae	VBZ
cord-275433-58unu79x	316	38	p62	p62	NN
cord-275433-58unu79x	316	39	/	/	SYM
cord-275433-58unu79x	316	40	SQSTM1	sqstm1	NN
cord-275433-58unu79x	316	41	forms	form	VBZ
cord-275433-58unu79x	316	42	protein	protein	NN
cord-275433-58unu79x	316	43	aggregates	aggregate	NNS
cord-275433-58unu79x	316	44	degraded	degrade	VBN
cord-275433-58unu79x	316	45	by	by	IN
cord-275433-58unu79x	316	46	autophagy	autophagy	NN
cord-275433-58unu79x	316	47	and	and	CC
cord-275433-58unu79x	316	48	has	have	VBZ
cord-275433-58unu79x	316	49	a	a	DT
cord-275433-58unu79x	316	50	protective	protective	JJ
cord-275433-58unu79x	316	51	effect	effect	NN
cord-275433-58unu79x	316	52	on	on	IN
cord-275433-58unu79x	316	53	huntingtin	huntingtin	NNS
cord-275433-58unu79x	316	54	-	-	HYPH
cord-275433-58unu79x	316	55	induced	induce	VBN
cord-275433-58unu79x	316	56	cell	cell	NN
cord-275433-58unu79x	316	57	death	death	NN
cord-275433-58unu79x	316	58	Glycogen	Glycogen	NNP
cord-275433-58unu79x	316	59	autophagosomes	autophagosomes	VBP
cord-275433-58unu79x	316	60	in	in	IN
cord-275433-58unu79x	316	61	polymorphonuclear	polymorphonuclear	JJ
cord-275433-58unu79x	316	62	leukocytes	leukocyte	NNS
cord-275433-58unu79x	316	63	induced	induce	VBN
cord-275433-58unu79x	316	64	by	by	IN
cord-275433-58unu79x	316	65	rickettsiae	rickettsiae	NNP
cord-275433-58unu79x	317	1	This	this	DT
cord-275433-58unu79x	317	2	is	be	VBZ
cord-275433-58unu79x	317	3	an	an	DT
cord-275433-58unu79x	317	4	excellent	excellent	JJ
cord-275433-58unu79x	317	5	review	review	NN
cord-275433-58unu79x	317	6	of	of	IN
cord-275433-58unu79x	317	7	the	the	DT
cord-275433-58unu79x	317	8	complex	complex	JJ
cord-275433-58unu79x	317	9	relationships	relationship	NNS
cord-275433-58unu79x	317	10	between	between	IN
cord-275433-58unu79x	317	11	autophagy	autophagy	NN
cord-275433-58unu79x	317	12	and	and	CC
cord-275433-58unu79x	317	13	microorganisms	microorganism	NNS
cord-275433-58unu79x	317	14	Eating	eat	VBG
cord-275433-58unu79x	317	15	oneself	oneself	PRP
cord-275433-58unu79x	317	16	and	and	CC
cord-275433-58unu79x	317	17	uninvited	uninvited	JJ
cord-275433-58unu79x	317	18	guests	guest	NNS
cord-275433-58unu79x	317	19	;	;	:
cord-275433-58unu79x	317	20	autophagy	autophagy	NN
cord-275433-58unu79x	317	21	-	-	HYPH
cord-275433-58unu79x	317	22	related	relate	VBN
cord-275433-58unu79x	317	23	pathways	pathway	NNS
cord-275433-58unu79x	317	24	in	in	IN
cord-275433-58unu79x	317	25	cellular	cellular	JJ
cord-275433-58unu79x	317	26	defense	defense	NN
cord-275433-58unu79x	317	27	Role	role	NN
cord-275433-58unu79x	317	28	of	of	IN
cord-275433-58unu79x	317	29	phosphatidylinositol	phosphatidylinositol	JJ
cord-275433-58unu79x	317	30	3-kinase	3-kinase	CD
cord-275433-58unu79x	317	31	and	and	CC
cord-275433-58unu79x	317	32	Rab5	Rab5	NNP
cord-275433-58unu79x	317	33	effectors	effector	NNS
cord-275433-58unu79x	317	34	in	in	IN
cord-275433-58unu79x	317	35	phagosomal	phagosomal	NN
cord-275433-58unu79x	317	36	biogenesis	biogenesis	NN
cord-275433-58unu79x	317	37	and	and	CC
cord-275433-58unu79x	317	38	mycobacterial	mycobacterial	NNP
cord-275433-58unu79x	317	39	phagosome	phagosome	NNP
cord-275433-58unu79x	317	40	maturation	maturation	NN
cord-275433-58unu79x	317	41	arrest	arrest	NN
cord-275433-58unu79x	317	42	Mycobacterium	Mycobacterium	NNP
cord-275433-58unu79x	317	43	tuberculosis	tuberculosis	NN
cord-275433-58unu79x	317	44	phagosome	phagosome	NN
cord-275433-58unu79x	317	45	maturation	maturation	NN
cord-275433-58unu79x	317	46	arrest	arrest	NN
cord-275433-58unu79x	317	47	:	:	:
cord-275433-58unu79x	317	48	selective	selective	JJ
cord-275433-58unu79x	317	49	targeting	targeting	NN
cord-275433-58unu79x	317	50	of	of	IN
cord-275433-58unu79x	317	51	PI3P	pi3p	JJ
cord-275433-58unu79x	317	52	-	-	HYPH
cord-275433-58unu79x	317	53	dependent	dependent	JJ
cord-275433-58unu79x	317	54	membrane	membrane	NN
cord-275433-58unu79x	317	55	trafficking	traffic	VBG
cord-275433-58unu79x	317	56	Mycobacterium	Mycobacterium	NNP
cord-275433-58unu79x	317	57	tuberculosis	tuberculosis	NN
cord-275433-58unu79x	317	58	phagosome	phagosome	NN
cord-275433-58unu79x	317	59	maturation	maturation	NN
cord-275433-58unu79x	317	60	arrest	arrest	NN
cord-275433-58unu79x	317	61	:	:	:
cord-275433-58unu79x	318	1	mycobacterial	mycobacterial	NNP
cord-275433-58unu79x	318	2	phosphatidylinositol	phosphatidylinositol	NNP
cord-275433-58unu79x	318	3	analog	analog	NN
cord-275433-58unu79x	318	4	phosphatidylinositol	phosphatidylinositol	JJ
cord-275433-58unu79x	318	5	mannoside	mannoside	NN
cord-275433-58unu79x	318	6	stimulates	stimulate	VBZ
cord-275433-58unu79x	319	1	early	early	RB
cord-275433-58unu79x	319	2	endosomal	endosomal	NNP
cord-275433-58unu79x	319	3	fusion	fusion	NN
cord-275433-58unu79x	319	4	Autophagy	Autophagy	NNP
cord-275433-58unu79x	319	5	is	be	VBZ
cord-275433-58unu79x	319	6	a	a	DT
cord-275433-58unu79x	319	7	defense	defense	NN
cord-275433-58unu79x	319	8	mechanism	mechanism	NN
cord-275433-58unu79x	319	9	inhibiting	inhibit	VBG
cord-275433-58unu79x	319	10	BCG	BCG	NNP
cord-275433-58unu79x	319	11	and	and	CC
cord-275433-58unu79x	319	12	Mycobacterium	Mycobacterium	NNP
cord-275433-58unu79x	319	13	tuberculosis	tuberculosis	NN
cord-275433-58unu79x	319	14	survival	survival	NN
cord-275433-58unu79x	319	15	in	in	IN
cord-275433-58unu79x	319	16	infected	infected	JJ
cord-275433-58unu79x	319	17	macrophages	macrophage	NNS
cord-275433-58unu79x	319	18	Escape	Escape	NNP
cord-275433-58unu79x	319	19	of	of	IN
cord-275433-58unu79x	319	20	intracellular	intracellular	JJ
cord-275433-58unu79x	319	21	Shigella	Shigella	NNP
cord-275433-58unu79x	319	22	from	from	IN
cord-275433-58unu79x	319	23	autophagy	autophagy	NN
cord-275433-58unu79x	319	24	References	reference	NNS
cord-275433-58unu79x	319	25	42	42	CD
cord-275433-58unu79x	319	26	-	-	SYM
cord-275433-58unu79x	319	27	44	44	CD
cord-275433-58unu79x	319	28	are	be	VBP
cord-275433-58unu79x	319	29	landmark	landmark	NN
cord-275433-58unu79x	319	30	papers	paper	NNS
cord-275433-58unu79x	319	31	that	that	WDT
cord-275433-58unu79x	319	32	formed	form	VBD
cord-275433-58unu79x	319	33	the	the	DT
cord-275433-58unu79x	319	34	foundation	foundation	NN
cord-275433-58unu79x	319	35	for	for	IN
cord-275433-58unu79x	319	36	the	the	DT
cord-275433-58unu79x	319	37	principle	principle	NN
cord-275433-58unu79x	319	38	that	that	WDT
cord-275433-58unu79x	319	39	autophagy	autophagy	NN
cord-275433-58unu79x	319	40	is	be	VBZ
cord-275433-58unu79x	319	41	important	important	JJ
cord-275433-58unu79x	319	42	in	in	IN
cord-275433-58unu79x	319	43	defence	defence	NN
cord-275433-58unu79x	319	44	against	against	IN
cord-275433-58unu79x	319	45	intracellular	intracellular	JJ
cord-275433-58unu79x	319	46	bacterial	bacterial	JJ
cord-275433-58unu79x	319	47	pathogens	pathogen	NNS
cord-275433-58unu79x	319	48	(	(	-LRB-
cord-275433-58unu79x	319	49	such	such	JJ
cord-275433-58unu79x	319	50	as	as	IN
cord-275433-58unu79x	319	51	M.	M.	NNP
cord-275433-58unu79x	319	52	tuberculosis	tuberculosis	NN
cord-275433-58unu79x	319	53	and	and	CC
cord-275433-58unu79x	319	54	Shigella	Shigella	NNP
cord-275433-58unu79x	319	55	spp	spp	NNS
cord-275433-58unu79x	319	56	.	.	.
cord-275433-58unu79x	319	57	)	)	-RRB-
cord-275433-58unu79x	319	58	and	and	CC
cord-275433-58unu79x	319	59	extracellular	extracellular	JJ
cord-275433-58unu79x	319	60	bacterial	bacterial	JJ
cord-275433-58unu79x	319	61	pathogens	pathogen	NNS
cord-275433-58unu79x	319	62	that	that	WDT
cord-275433-58unu79x	319	63	invade	invade	VBP
cord-275433-58unu79x	319	64	the	the	DT
cord-275433-58unu79x	319	65	cytosol	cytosol	NN
cord-275433-58unu79x	320	1	This	this	DT
cord-275433-58unu79x	320	2	paper	paper	NN
cord-275433-58unu79x	320	3	identified	identify	VBD
cord-275433-58unu79x	320	4	an	an	DT
cord-275433-58unu79x	320	5	important	important	JJ
cord-275433-58unu79x	320	6	signalling	signalling	NN
cord-275433-58unu79x	320	7	mechanism	mechanism	NN
cord-275433-58unu79x	320	8	(	(	-LRB-
cord-275433-58unu79x	320	9	involving	involve	VBG
cord-275433-58unu79x	320	10	IRGM	IRGM	NNP
cord-275433-58unu79x	320	11	)	)	-RRB-
cord-275433-58unu79x	320	12	that	that	WDT
cord-275433-58unu79x	320	13	activates	activate	VBZ
cord-275433-58unu79x	320	14	autophagy	autophagy	NN
cord-275433-58unu79x	320	15	-	-	HYPH
cord-275433-58unu79x	320	16	dependent	dependent	JJ
cord-275433-58unu79x	320	17	control	control	NN
cord-275433-58unu79x	320	18	of	of	IN
cord-275433-58unu79x	320	19	mycobacteria	mycobacterium	NNS
cord-275433-58unu79x	320	20	Cytoplasmic	Cytoplasmic	NNP
cord-275433-58unu79x	320	21	bacteria	bacteria	NNS
cord-275433-58unu79x	320	22	can	can	MD
cord-275433-58unu79x	320	23	be	be	VB
cord-275433-58unu79x	320	24	targets	target	NNS
cord-275433-58unu79x	320	25	for	for	IN
cord-275433-58unu79x	320	26	autophagy	autophagy	NN
cord-275433-58unu79x	321	1	Autophagy	Autophagy	NNP
cord-275433-58unu79x	321	2	limits	limit	VBZ
cord-275433-58unu79x	321	3	Listeria	Listeria	NNP
cord-275433-58unu79x	321	4	monocytogenes	monocytogenes	NN
cord-275433-58unu79x	321	5	intracellular	intracellular	JJ
cord-275433-58unu79x	321	6	growth	growth	NN
cord-275433-58unu79x	321	7	in	in	IN
cord-275433-58unu79x	321	8	the	the	DT
cord-275433-58unu79x	321	9	early	early	JJ
cord-275433-58unu79x	321	10	phase	phase	NN
cord-275433-58unu79x	321	11	of	of	IN
cord-275433-58unu79x	321	12	primary	primary	JJ
cord-275433-58unu79x	321	13	infection	infection	NN
cord-275433-58unu79x	322	1	Autophagy	Autophagy	NNP
cord-275433-58unu79x	322	2	controls	control	VBZ
cord-275433-58unu79x	322	3	Salmonella	Salmonella	NNP
cord-275433-58unu79x	322	4	infection	infection	NN
cord-275433-58unu79x	322	5	in	in	IN
cord-275433-58unu79x	322	6	response	response	NN
cord-275433-58unu79x	322	7	to	to	IN
cord-275433-58unu79x	322	8	damage	damage	NN
cord-275433-58unu79x	322	9	to	to	IN
cord-275433-58unu79x	322	10	the	the	DT
cord-275433-58unu79x	322	11	Salmonella	Salmonella	NNP
cord-275433-58unu79x	322	12	-	-	HYPH
cord-275433-58unu79x	322	13	containing	contain	VBG
cord-275433-58unu79x	322	14	vacuole	vacuole	NN
cord-275433-58unu79x	322	15	Autophagy	Autophagy	NNP
cord-275433-58unu79x	322	16	-	-	HYPH
cord-275433-58unu79x	322	17	mediated	mediate	VBN
cord-275433-58unu79x	322	18	reentry	reentry	NN
cord-275433-58unu79x	322	19	of	of	IN
cord-275433-58unu79x	322	20	Francisella	Francisella	NNP
cord-275433-58unu79x	322	21	tularensis	tularensis	NNP
cord-275433-58unu79x	322	22	into	into	IN
cord-275433-58unu79x	322	23	the	the	DT
cord-275433-58unu79x	322	24	endocytic	endocytic	JJ
cord-275433-58unu79x	322	25	compartment	compartment	NN
cord-275433-58unu79x	322	26	after	after	IN
cord-275433-58unu79x	322	27	cytoplasmic	cytoplasmic	JJ
cord-275433-58unu79x	322	28	replication	replication	NN
cord-275433-58unu79x	322	29	Autophagy	Autophagy	NNP
cord-275433-58unu79x	322	30	-	-	HYPH
cord-275433-58unu79x	322	31	mediated	mediate	VBN
cord-275433-58unu79x	322	32	clearance	clearance	NN
cord-275433-58unu79x	322	33	of	of	IN
cord-275433-58unu79x	322	34	huntingtin	huntingtin	NNP
cord-275433-58unu79x	322	35	aggregates	aggregate	NNS
cord-275433-58unu79x	322	36	triggered	trigger	VBN
cord-275433-58unu79x	322	37	by	by	IN
cord-275433-58unu79x	322	38	the	the	DT
cord-275433-58unu79x	322	39	insulin	insulin	NN
cord-275433-58unu79x	322	40	-	-	HYPH
cord-275433-58unu79x	322	41	signaling	signal	VBG
cord-275433-58unu79x	322	42	pathway	pathway	NN
cord-275433-58unu79x	322	43	Intracellular	Intracellular	NNP
cord-275433-58unu79x	322	44	survival	survival	NN
cord-275433-58unu79x	322	45	of	of	IN
cord-275433-58unu79x	322	46	Shigella	Shigella	NNP
cord-275433-58unu79x	323	1	The	the	DT
cord-275433-58unu79x	323	2	ubiquitin	ubiquitin	NN
cord-275433-58unu79x	323	3	ligase	ligase	NN
cord-275433-58unu79x	323	4	Cbl	Cbl	NNP
cord-275433-58unu79x	323	5	-	-	HYPH
cord-275433-58unu79x	323	6	b	b	NN
cord-275433-58unu79x	323	7	limits	limit	VBZ
cord-275433-58unu79x	323	8	Pseudomonas	Pseudomonas	NNP
cord-275433-58unu79x	323	9	aeruginosa	aeruginosa	NN
cord-275433-58unu79x	324	1	exotoxin	exotoxin	NNP
cord-275433-58unu79x	324	2	T	T	NNP
cord-275433-58unu79x	324	3	-	-	HYPH
cord-275433-58unu79x	324	4	mediated	mediate	VBN
cord-275433-58unu79x	324	5	virulence	virulence	NN
cord-275433-58unu79x	324	6	NF	nf	NN
cord-275433-58unu79x	324	7	-	-	HYPH
cord-275433-58unu79x	324	8	κB	κb	CD
cord-275433-58unu79x	324	9	activation	activation	NN
cord-275433-58unu79x	324	10	represses	repress	VBZ
cord-275433-58unu79x	324	11	tumor	tumor	NN
cord-275433-58unu79x	324	12	necrosis	necrosis	NN
cord-275433-58unu79x	324	13	factor	factor	NN
cord-275433-58unu79x	324	14	-	-	HYPH
cord-275433-58unu79x	324	15	α	α	NN
cord-275433-58unu79x	324	16	-	-	HYPH
cord-275433-58unu79x	324	17	induced	induce	VBN
cord-275433-58unu79x	324	18	autophagy	autophagy	NN
cord-275433-58unu79x	324	19	Reactive	reactive	JJ
cord-275433-58unu79x	324	20	oxygen	oxygen	NN
cord-275433-58unu79x	324	21	species	specie	NNS
cord-275433-58unu79x	324	22	are	be	VBP
cord-275433-58unu79x	324	23	essential	essential	JJ
cord-275433-58unu79x	324	24	for	for	IN
cord-275433-58unu79x	324	25	autophagy	autophagy	NN
cord-275433-58unu79x	324	26	and	and	CC
cord-275433-58unu79x	324	27	specifically	specifically	RB
cord-275433-58unu79x	324	28	regulate	regulate	VB
cord-275433-58unu79x	324	29	the	the	DT
cord-275433-58unu79x	324	30	activity	activity	NN
cord-275433-58unu79x	324	31	of	of	IN
cord-275433-58unu79x	324	32	Atg4	Atg4	NNP
cord-275433-58unu79x	324	33	PKR	PKR	NNP
cord-275433-58unu79x	324	34	-	-	HYPH
cord-275433-58unu79x	324	35	dependent	dependent	JJ
cord-275433-58unu79x	324	36	autophagic	autophagic	JJ
cord-275433-58unu79x	324	37	degradation	degradation	NN
cord-275433-58unu79x	324	38	of	of	IN
cord-275433-58unu79x	324	39	herpes	herpes	NNP
cord-275433-58unu79x	324	40	simplex	simplex	NNP
cord-275433-58unu79x	324	41	virus	virus	NN
cord-275433-58unu79x	324	42	type	type	NN
cord-275433-58unu79x	324	43	1	1	CD
cord-275433-58unu79x	324	44	Subversion	subversion	NN
cord-275433-58unu79x	324	45	of	of	IN
cord-275433-58unu79x	324	46	cellular	cellular	JJ
cord-275433-58unu79x	324	47	autophagosomal	autophagosomal	NN
cord-275433-58unu79x	324	48	machinery	machinery	NN
cord-275433-58unu79x	324	49	by	by	IN
cord-275433-58unu79x	324	50	RNA	RNA	NNP
cord-275433-58unu79x	324	51	viruses	virus	NNS
cord-275433-58unu79x	325	1	References	reference	NNS
cord-275433-58unu79x	325	2	56	56	CD
cord-275433-58unu79x	325	3	-	-	SYM
cord-275433-58unu79x	325	4	57	57	CD
cord-275433-58unu79x	325	5	indicate	indicate	VBP
cord-275433-58unu79x	325	6	a	a	DT
cord-275433-58unu79x	325	7	role	role	NN
cord-275433-58unu79x	325	8	for	for	IN
cord-275433-58unu79x	325	9	components	component	NNS
cord-275433-58unu79x	325	10	of	of	IN
cord-275433-58unu79x	325	11	the	the	DT
cord-275433-58unu79x	325	12	autophagic	autophagic	NNP
cord-275433-58unu79x	325	13	machinery	machinery	NN
cord-275433-58unu79x	325	14	in	in	IN
cord-275433-58unu79x	325	15	the	the	DT
cord-275433-58unu79x	325	16	establishment	establishment	NN
cord-275433-58unu79x	325	17	of	of	IN
cord-275433-58unu79x	325	18	viral	viral	JJ
cord-275433-58unu79x	325	19	replication	replication	NN
cord-275433-58unu79x	325	20	complexes	complex	NNS
cord-275433-58unu79x	325	21	COPI	COPI	NNP
cord-275433-58unu79x	325	22	activity	activity	NN
cord-275433-58unu79x	325	23	coupled	couple	VBN
cord-275433-58unu79x	325	24	with	with	IN
cord-275433-58unu79x	325	25	fatty	fatty	JJ
cord-275433-58unu79x	325	26	acid	acid	NN
cord-275433-58unu79x	325	27	biosynthesis	biosynthesis	NN
cord-275433-58unu79x	325	28	is	be	VBZ
cord-275433-58unu79x	325	29	required	require	VBN
cord-275433-58unu79x	325	30	for	for	IN
cord-275433-58unu79x	325	31	viral	viral	JJ
cord-275433-58unu79x	325	32	replication	replication	NN
cord-275433-58unu79x	326	1	Cellular	cellular	JJ
cord-275433-58unu79x	326	2	autophagy	autophagy	NN
cord-275433-58unu79x	326	3	machinery	machinery	NN
cord-275433-58unu79x	326	4	is	be	VBZ
cord-275433-58unu79x	326	5	not	not	RB
cord-275433-58unu79x	326	6	required	require	VBN
cord-275433-58unu79x	326	7	for	for	IN
cord-275433-58unu79x	326	8	vaccinia	vaccinia	NN
cord-275433-58unu79x	326	9	virus	virus	NN
cord-275433-58unu79x	326	10	replication	replication	NN
cord-275433-58unu79x	326	11	and	and	CC
cord-275433-58unu79x	326	12	maturation	maturation	NN
cord-275433-58unu79x	327	1	This	this	DT
cord-275433-58unu79x	327	2	paper	paper	NN
cord-275433-58unu79x	327	3	provided	provide	VBD
cord-275433-58unu79x	327	4	the	the	DT
cord-275433-58unu79x	327	5	first	first	JJ
cord-275433-58unu79x	327	6	demonstration	demonstration	NN
cord-275433-58unu79x	327	7	that	that	WDT
cord-275433-58unu79x	327	8	loss	loss	NN
cord-275433-58unu79x	327	9	-	-	HYPH
cord-275433-58unu79x	327	10	of	of	IN
cord-275433-58unu79x	327	11	-	-	HYPH
cord-275433-58unu79x	327	12	function	function	NN
cord-275433-58unu79x	327	13	mutations	mutation	NNS
cord-275433-58unu79x	327	14	of	of	IN
cord-275433-58unu79x	327	15	autophagy	autophagy	NN
cord-275433-58unu79x	327	16	genes	gene	NNS
cord-275433-58unu79x	327	17	increases	increase	VBZ
cord-275433-58unu79x	327	18	susceptibility	susceptibility	NN
cord-275433-58unu79x	327	19	to	to	IN
cord-275433-58unu79x	327	20	microbial	microbial	JJ
cord-275433-58unu79x	327	21	infection	infection	NN
cord-275433-58unu79x	327	22	in	in	IN
cord-275433-58unu79x	327	23	vivo	vivo	NNP
cord-275433-58unu79x	327	24	Protection	Protection	NNP
cord-275433-58unu79x	327	25	against	against	IN
cord-275433-58unu79x	327	26	fatal	fatal	JJ
cord-275433-58unu79x	327	27	Sindbis	Sindbis	NNP
cord-275433-58unu79x	327	28	virus	virus	NN
cord-275433-58unu79x	327	29	encephalitis	encephalitis	RB
cord-275433-58unu79x	327	30	by	by	IN
cord-275433-58unu79x	327	31	Beclin	Beclin	NNP
cord-275433-58unu79x	327	32	,	,	,
cord-275433-58unu79x	327	33	a	a	DT
cord-275433-58unu79x	327	34	novel	novel	NN
cord-275433-58unu79x	327	35	Bcl-2-interacting	Bcl-2-interacting	NNP
cord-275433-58unu79x	327	36	protein	protein	NN
cord-275433-58unu79x	328	1	This	this	DT
cord-275433-58unu79x	328	2	paper	paper	NN
cord-275433-58unu79x	328	3	provided	provide	VBD
cord-275433-58unu79x	328	4	the	the	DT
cord-275433-58unu79x	328	5	first	first	JJ
cord-275433-58unu79x	328	6	evidence	evidence	NN
cord-275433-58unu79x	328	7	suggesting	suggest	VBG
cord-275433-58unu79x	328	8	that	that	IN
cord-275433-58unu79x	328	9	autophagy	autophagy	NN
cord-275433-58unu79x	328	10	inhibition	inhibition	NN
cord-275433-58unu79x	328	11	is	be	VBZ
cord-275433-58unu79x	328	12	a	a	DT
cord-275433-58unu79x	328	13	mechanism	mechanism	NN
cord-275433-58unu79x	328	14	by	by	IN
cord-275433-58unu79x	328	15	which	which	WDT
cord-275433-58unu79x	328	16	viruses	virus	NNS
cord-275433-58unu79x	328	17	evade	evade	VBP
cord-275433-58unu79x	328	18	innate	innate	JJ
cord-275433-58unu79x	328	19	immunity	immunity	NN
cord-275433-58unu79x	328	20	and	and	CC
cord-275433-58unu79x	328	21	cause	cause	VB
cord-275433-58unu79x	328	22	disease	disease	NN
cord-275433-58unu79x	328	23	Autophagy	Autophagy	NNP
cord-275433-58unu79x	328	24	in	in	IN
cord-275433-58unu79x	328	25	Immunity	Immunity	NNP
cord-275433-58unu79x	328	26	and	and	CC
cord-275433-58unu79x	328	27	Infection	infection	NN
cord-275433-58unu79x	328	28	:	:	:
cord-275433-58unu79x	328	29	a	a	DT
cord-275433-58unu79x	328	30	novel	novel	JJ
cord-275433-58unu79x	328	31	immune	immune	NN
cord-275433-58unu79x	328	32	effector	effector	NN
cord-275433-58unu79x	328	33	Innate	Innate	NNP
cord-275433-58unu79x	328	34	immune	immune	JJ
cord-275433-58unu79x	328	35	recognition	recognition	NN
cord-275433-58unu79x	328	36	of	of	IN
cord-275433-58unu79x	328	37	viral	viral	JJ
cord-275433-58unu79x	328	38	infection	infection	NN
cord-275433-58unu79x	328	39	Toll	toll	NN
cord-275433-58unu79x	328	40	-	-	HYPH
cord-275433-58unu79x	328	41	like	like	JJ
cord-275433-58unu79x	328	42	receptor	receptor	NN
cord-275433-58unu79x	328	43	9-mediated	9-mediated	CD
cord-275433-58unu79x	328	44	recognition	recognition	NN
cord-275433-58unu79x	328	45	of	of	IN
cord-275433-58unu79x	328	46	herpes	herpes	NNP
cord-275433-58unu79x	328	47	simplex	simplex	NNP
cord-275433-58unu79x	328	48	virus-2	virus-2	NNP
cord-275433-58unu79x	328	49	by	by	IN
cord-275433-58unu79x	328	50	plasmacytoid	plasmacytoid	NNP
cord-275433-58unu79x	328	51	dendritic	dendritic	JJ
cord-275433-58unu79x	328	52	cells	cell	NNS
cord-275433-58unu79x	328	53	Excessive	excessive	JJ
cord-275433-58unu79x	328	54	degradation	degradation	NN
cord-275433-58unu79x	328	55	of	of	IN
cord-275433-58unu79x	328	56	intracellular	intracellular	JJ
cord-275433-58unu79x	328	57	protein	protein	NN
cord-275433-58unu79x	328	58	in	in	IN
cord-275433-58unu79x	328	59	macrophages	macrophage	NNS
cord-275433-58unu79x	328	60	prevents	prevent	VBZ
cord-275433-58unu79x	328	61	presentation	presentation	NN
cord-275433-58unu79x	328	62	in	in	IN
cord-275433-58unu79x	328	63	the	the	DT
cord-275433-58unu79x	328	64	context	context	NN
cord-275433-58unu79x	328	65	of	of	IN
cord-275433-58unu79x	328	66	major	major	JJ
cord-275433-58unu79x	328	67	histocompatibility	histocompatibility	NN
cord-275433-58unu79x	328	68	complex	complex	JJ
cord-275433-58unu79x	328	69	class	class	NN
cord-275433-58unu79x	328	70	II	ii	CD
cord-275433-58unu79x	328	71	molecules	molecule	NNS
cord-275433-58unu79x	329	1	Major	major	JJ
cord-275433-58unu79x	329	2	histocompatibility	histocompatibility	NN
cord-275433-58unu79x	329	3	complex	complex	JJ
cord-275433-58unu79x	329	4	class	class	NN
cord-275433-58unu79x	329	5	II	ii	NN
cord-275433-58unu79x	329	6	-	-	HYPH
cord-275433-58unu79x	329	7	restricted	restrict	VBN
cord-275433-58unu79x	329	8	presentation	presentation	NN
cord-275433-58unu79x	329	9	of	of	IN
cord-275433-58unu79x	329	10	a	a	DT
cord-275433-58unu79x	329	11	cytosolic	cytosolic	JJ
cord-275433-58unu79x	329	12	antigen	antigen	NN
cord-275433-58unu79x	329	13	by	by	IN
cord-275433-58unu79x	329	14	autophagy	autophagy	NN
cord-275433-58unu79x	329	15	Processing	processing	NN
cord-275433-58unu79x	329	16	and	and	CC
cord-275433-58unu79x	329	17	presentation	presentation	NN
cord-275433-58unu79x	329	18	of	of	IN
cord-275433-58unu79x	329	19	HLA	HLA	NNP
cord-275433-58unu79x	329	20	class	class	NN
cord-275433-58unu79x	329	21	I	i	NN
cord-275433-58unu79x	329	22	and	and	CC
cord-275433-58unu79x	329	23	II	II	NNP
cord-275433-58unu79x	329	24	epitopes	epitope	NNS
cord-275433-58unu79x	329	25	by	by	IN
cord-275433-58unu79x	329	26	dendritic	dendritic	JJ
cord-275433-58unu79x	329	27	cells	cell	NNS
cord-275433-58unu79x	329	28	after	after	IN
cord-275433-58unu79x	329	29	transfection	transfection	NN
cord-275433-58unu79x	329	30	with	with	IN
cord-275433-58unu79x	329	31	in	in	IN
cord-275433-58unu79x	330	1	vitro	vitro	FW
cord-275433-58unu79x	330	2	-	-	:
cord-275433-58unu79x	330	3	transcribed	transcribe	VBN
cord-275433-58unu79x	330	4	MUC1	MUC1	NNP
cord-275433-58unu79x	330	5	RNA	RNA	NNP
cord-275433-58unu79x	330	6	Autophagy	Autophagy	NNP
cord-275433-58unu79x	330	7	promotes	promote	VBZ
cord-275433-58unu79x	330	8	MHC	MHC	NNP
cord-275433-58unu79x	330	9	class	class	NN
cord-275433-58unu79x	330	10	II	II	NNP
cord-275433-58unu79x	330	11	presentation	presentation	NN
cord-275433-58unu79x	330	12	of	of	IN
cord-275433-58unu79x	330	13	peptides	peptide	NNS
cord-275433-58unu79x	330	14	from	from	IN
cord-275433-58unu79x	330	15	intracellular	intracellular	JJ
cord-275433-58unu79x	330	16	source	source	NN
cord-275433-58unu79x	330	17	proteins	protein	NNS
cord-275433-58unu79x	331	1	This	this	DT
cord-275433-58unu79x	331	2	paper	paper	NN
cord-275433-58unu79x	331	3	provided	provide	VBD
cord-275433-58unu79x	331	4	the	the	DT
cord-275433-58unu79x	331	5	first	first	JJ
cord-275433-58unu79x	331	6	genetic	genetic	JJ
cord-275433-58unu79x	331	7	evidence	evidence	NN
cord-275433-58unu79x	331	8	that	that	WDT
cord-275433-58unu79x	331	9	autophagy	autophagy	VBP
cord-275433-58unu79x	331	10	components	component	NNS
cord-275433-58unu79x	331	11	can	can	MD
cord-275433-58unu79x	331	12	be	be	VB
cord-275433-58unu79x	331	13	required	require	VBN
cord-275433-58unu79x	331	14	for	for	IN
cord-275433-58unu79x	331	15	efficient	efficient	JJ
cord-275433-58unu79x	331	16	MHC	MHC	NNP
cord-275433-58unu79x	331	17	class	class	NN
cord-275433-58unu79x	331	18	II	II	NNP
cord-275433-58unu79x	331	19	presentation	presentation	NN
cord-275433-58unu79x	331	20	of	of	IN
cord-275433-58unu79x	331	21	an	an	DT
cord-275433-58unu79x	331	22	endogenous	endogenous	JJ
cord-275433-58unu79x	331	23	antigen	antigen	NN
cord-275433-58unu79x	331	24	This	this	DT
cord-275433-58unu79x	331	25	paper	paper	NN
cord-275433-58unu79x	331	26	describes	describe	VBZ
cord-275433-58unu79x	331	27	the	the	DT
cord-275433-58unu79x	331	28	characterization	characterization	NN
cord-275433-58unu79x	331	29	of	of	IN
cord-275433-58unu79x	331	30	transgenic	transgenic	JJ
cord-275433-58unu79x	331	31	autophagy	autophagy	NN
cord-275433-58unu79x	331	32	reporter	reporter	NN
cord-275433-58unu79x	331	33	mice	mouse	NNS
cord-275433-58unu79x	331	34	(	(	-LRB-
cord-275433-58unu79x	331	35	a	a	DT
cord-275433-58unu79x	331	36	tool	tool	NN
cord-275433-58unu79x	331	37	that	that	WDT
cord-275433-58unu79x	331	38	has	have	VBZ
cord-275433-58unu79x	331	39	greatly	greatly	RB
cord-275433-58unu79x	331	40	facilitated	facilitate	VBN
cord-275433-58unu79x	331	41	the	the	DT
cord-275433-58unu79x	331	42	study	study	NN
cord-275433-58unu79x	331	43	of	of	IN
cord-275433-58unu79x	331	44	autophagy	autophagy	NN
cord-275433-58unu79x	331	45	in	in	IN
cord-275433-58unu79x	331	46	vivo	vivo	NNP
cord-275433-58unu79x	331	47	)	)	-RRB-
cord-275433-58unu79x	331	48	and	and	CC
cord-275433-58unu79x	331	49	the	the	DT
cord-275433-58unu79x	331	50	presence	presence	NN
cord-275433-58unu79x	331	51	of	of	IN
cord-275433-58unu79x	331	52	high	high	JJ
cord-275433-58unu79x	331	53	levels	level	NNS
cord-275433-58unu79x	331	54	of	of	IN
cord-275433-58unu79x	331	55	autophagy	autophagy	NN
cord-275433-58unu79x	331	56	A	a	DT
cord-275433-58unu79x	331	57	role	role	NN
cord-275433-58unu79x	331	58	for	for	IN
cord-275433-58unu79x	331	59	intercellular	intercellular	JJ
cord-275433-58unu79x	331	60	antigen	antigen	NN
cord-275433-58unu79x	331	61	transfer	transfer	NN
cord-275433-58unu79x	331	62	in	in	IN
cord-275433-58unu79x	331	63	the	the	DT
cord-275433-58unu79x	331	64	recognition	recognition	NN
cord-275433-58unu79x	331	65	of	of	IN
cord-275433-58unu79x	331	66	EBV	EBV	NNP
cord-275433-58unu79x	331	67	-	-	HYPH
cord-275433-58unu79x	331	68	transformed	transform	VBN
cord-275433-58unu79x	331	69	B	b	NN
cord-275433-58unu79x	331	70	cell	cell	NN
cord-275433-58unu79x	331	71	lines	line	NNS
cord-275433-58unu79x	331	72	by	by	IN
cord-275433-58unu79x	331	73	EBV	EBV	NNP
cord-275433-58unu79x	331	74	nuclear	nuclear	JJ
cord-275433-58unu79x	331	75	antigen	antigen	NN
cord-275433-58unu79x	331	76	-	-	HYPH
cord-275433-58unu79x	331	77	specific	specific	JJ
cord-275433-58unu79x	331	78	CD4	CD4	NNP
cord-275433-58unu79x	331	79	+	+	CC
cord-275433-58unu79x	331	80	T	t	NN
cord-275433-58unu79x	331	81	cells	cell	NNS
cord-275433-58unu79x	332	1	This	this	DT
cord-275433-58unu79x	332	2	paper	paper	NN
cord-275433-58unu79x	332	3	provided	provide	VBD
cord-275433-58unu79x	332	4	the	the	DT
cord-275433-58unu79x	332	5	first	first	JJ
cord-275433-58unu79x	332	6	evidence	evidence	NN
cord-275433-58unu79x	332	7	that	that	IN
cord-275433-58unu79x	332	8	autophagy	autophagy	NN
cord-275433-58unu79x	332	9	occurs	occur	VBZ
cord-275433-58unu79x	332	10	constitutively	constitutively	RB
cord-275433-58unu79x	332	11	in	in	IN
cord-275433-58unu79x	332	12	antigenpresenting	antigenpresente	VBG
cord-275433-58unu79x	332	13	cells	cell	NNS
cord-275433-58unu79x	332	14	and	and	CC
cord-275433-58unu79x	332	15	also	also	RB
cord-275433-58unu79x	332	16	demonstrated	demonstrate	VBD
cord-275433-58unu79x	332	17	that	that	IN
cord-275433-58unu79x	332	18	presentation	presentation	NN
cord-275433-58unu79x	332	19	of	of	IN
cord-275433-58unu79x	332	20	an	an	DT
cord-275433-58unu79x	332	21	influenza	influenza	NN
cord-275433-58unu79x	332	22	virus	virus	NN
cord-275433-58unu79x	332	23	antigen	antigen	NN
cord-275433-58unu79x	332	24	can	can	MD
cord-275433-58unu79x	332	25	be	be	VB
cord-275433-58unu79x	332	26	enhanced	enhance	VBN
cord-275433-58unu79x	332	27	by	by	IN
cord-275433-58unu79x	332	28	specifically	specifically	RB
cord-275433-58unu79x	332	29	targeting	target	VBG
cord-275433-58unu79x	332	30	it	-PRON-	PRP
cord-275433-58unu79x	332	31	to	to	IN
cord-275433-58unu79x	332	32	autophagosomes	autophagosomes	NNP
cord-275433-58unu79x	332	33	.	.	.
cord-275433-58unu79x	333	1	The	the	DT
cord-275433-58unu79x	333	2	latter	latter	JJ
cord-275433-58unu79x	333	3	finding	finding	NN
cord-275433-58unu79x	333	4	has	have	VBZ
cord-275433-58unu79x	333	5	important	important	JJ
cord-275433-58unu79x	333	6	implications	implication	NNS
cord-275433-58unu79x	333	7	for	for	IN
cord-275433-58unu79x	333	8	vaccine	vaccine	NN
cord-275433-58unu79x	333	9	design	design	NN
cord-275433-58unu79x	333	10	Chaperone	chaperone	NN
cord-275433-58unu79x	333	11	-	-	HYPH
cord-275433-58unu79x	333	12	mediated	mediate	VBN
cord-275433-58unu79x	333	13	autophagy	autophagy	NN
cord-275433-58unu79x	333	14	in	in	IN
cord-275433-58unu79x	333	15	aging	age	VBG
cord-275433-58unu79x	333	16	and	and	CC
cord-275433-58unu79x	333	17	disease	disease	NN
cord-275433-58unu79x	333	18	Autophagy	Autophagy	NNP
cord-275433-58unu79x	333	19	:	:	:
cord-275433-58unu79x	333	20	many	many	JJ
cord-275433-58unu79x	333	21	paths	path	NNS
cord-275433-58unu79x	333	22	to	to	IN
cord-275433-58unu79x	333	23	the	the	DT
cord-275433-58unu79x	333	24	same	same	JJ
cord-275433-58unu79x	333	25	end	end	NN
cord-275433-58unu79x	333	26	Lamp-2a	lamp-2a	NN
cord-275433-58unu79x	333	27	facilitates	facilitate	VBZ
cord-275433-58unu79x	333	28	MHC	MHC	NNP
cord-275433-58unu79x	333	29	class	class	NN
cord-275433-58unu79x	333	30	II	II	NNP
cord-275433-58unu79x	333	31	presentation	presentation	NN
cord-275433-58unu79x	333	32	of	of	IN
cord-275433-58unu79x	333	33	cytoplasmic	cytoplasmic	JJ
cord-275433-58unu79x	333	34	antigens	antigen	NNS
cord-275433-58unu79x	333	35	This	this	DT
cord-275433-58unu79x	333	36	paper	paper	NN
cord-275433-58unu79x	333	37	demonstrated	demonstrate	VBD
cord-275433-58unu79x	333	38	that	that	IN
cord-275433-58unu79x	333	39	the	the	DT
cord-275433-58unu79x	333	40	IFN	IFN	NNP
cord-275433-58unu79x	333	41	-	-	HYPH
cord-275433-58unu79x	333	42	inducible	inducible	JJ
cord-275433-58unu79x	333	43	,	,	,
cord-275433-58unu79x	333	44	antiviral	antiviral	JJ
cord-275433-58unu79x	333	45	signalling	signalling	NN
cord-275433-58unu79x	333	46	molecule	molecule	NN
cord-275433-58unu79x	333	47	PKR	PKR	NNP
cord-275433-58unu79x	333	48	is	be	VBZ
cord-275433-58unu79x	333	49	required	require	VBN
cord-275433-58unu79x	333	50	for	for	IN
cord-275433-58unu79x	333	51	virus	virus	NN
cord-275433-58unu79x	333	52	DAP	dap	NN
cord-275433-58unu79x	333	53	kinase	kinase	NN
cord-275433-58unu79x	333	54	and	and	CC
cord-275433-58unu79x	333	55	DRP-1	DRP-1	NNP
cord-275433-58unu79x	333	56	mediate	mediate	VB
cord-275433-58unu79x	333	57	membrane	membrane	NN
cord-275433-58unu79x	333	58	blebbing	blebbing	NN
cord-275433-58unu79x	333	59	and	and	CC
cord-275433-58unu79x	333	60	the	the	DT
cord-275433-58unu79x	333	61	formation	formation	NN
cord-275433-58unu79x	333	62	of	of	IN
cord-275433-58unu79x	333	63	autophagic	autophagic	JJ
cord-275433-58unu79x	333	64	vesicles	vesicle	NNS
cord-275433-58unu79x	333	65	during	during	IN
cord-275433-58unu79x	333	66	programmed	programmed	JJ
cord-275433-58unu79x	333	67	cell	cell	NN
cord-275433-58unu79x	333	68	death	death	NN
cord-275433-58unu79x	333	69	Essential	essential	JJ
cord-275433-58unu79x	333	70	roles	role	NNS
cord-275433-58unu79x	333	71	of	of	IN
cord-275433-58unu79x	333	72	Atg5	Atg5	NNP
cord-275433-58unu79x	333	73	and	and	CC
cord-275433-58unu79x	333	74	FADD	FADD	NNP
cord-275433-58unu79x	333	75	in	in	IN
cord-275433-58unu79x	333	76	autophagic	autophagic	JJ
cord-275433-58unu79x	333	77	cell	cell	NN
cord-275433-58unu79x	333	78	death	death	NN
cord-275433-58unu79x	333	79	:	:	:
cord-275433-58unu79x	333	80	dissection	dissection	NN
cord-275433-58unu79x	333	81	of	of	IN
cord-275433-58unu79x	333	82	autophagic	autophagic	JJ
cord-275433-58unu79x	333	83	cell	cell	NN
cord-275433-58unu79x	333	84	death	death	NN
cord-275433-58unu79x	333	85	into	into	IN
cord-275433-58unu79x	333	86	vacuole	vacuole	NN
cord-275433-58unu79x	333	87	formation	formation	NN
cord-275433-58unu79x	333	88	and	and	CC
cord-275433-58unu79x	333	89	cell	cell	NN
cord-275433-58unu79x	333	90	death	death	NN
cord-275433-58unu79x	334	1	Insulin	insulin	NN
cord-275433-58unu79x	334	2	-	-	HYPH
cord-275433-58unu79x	334	3	like	like	JJ
cord-275433-58unu79x	334	4	growth	growth	NN
cord-275433-58unu79x	334	5	factor-1	factor-1	NNP
cord-275433-58unu79x	334	6	and	and	CC
cord-275433-58unu79x	334	7	TNF	TNF	NNP
cord-275433-58unu79x	334	8	-	-	HYPH
cord-275433-58unu79x	334	9	α	α	NN
cord-275433-58unu79x	334	10	regulate	regulate	VBP
cord-275433-58unu79x	334	11	autophagy	autophagy	NN
cord-275433-58unu79x	334	12	through	through	IN
cord-275433-58unu79x	334	13	c	c	NNP
cord-275433-58unu79x	334	14	-	-	:
cord-275433-58unu79x	334	15	jun	jun	NNP
cord-275433-58unu79x	334	16	N	N	NNP
cord-275433-58unu79x	334	17	-	-	HYPH
cord-275433-58unu79x	334	18	terminal	terminal	NN
cord-275433-58unu79x	334	19	kinase	kinase	NN
cord-275433-58unu79x	334	20	and	and	CC
cord-275433-58unu79x	334	21	Akt	Akt	NNP
cord-275433-58unu79x	334	22	pathways	pathway	NNS
cord-275433-58unu79x	334	23	in	in	IN
cord-275433-58unu79x	334	24	human	human	JJ
cord-275433-58unu79x	334	25	atherosclerotic	atherosclerotic	JJ
cord-275433-58unu79x	334	26	vascular	vascular	JJ
cord-275433-58unu79x	334	27	smooth	smooth	JJ
cord-275433-58unu79x	334	28	cells	cell	NNS
cord-275433-58unu79x	334	29	CD40-TRAF6	CD40-TRAF6	NNS
cord-275433-58unu79x	334	30	and	and	CC
cord-275433-58unu79x	334	31	autophagy	autophagy	NN
cord-275433-58unu79x	334	32	-	-	HYPH
cord-275433-58unu79x	334	33	dependent	dependent	JJ
cord-275433-58unu79x	334	34	antimicrobial	antimicrobial	JJ
cord-275433-58unu79x	334	35	activity	activity	NN
cord-275433-58unu79x	334	36	in	in	IN
cord-275433-58unu79x	334	37	macrophages	macrophage	NNS
cord-275433-58unu79x	334	38	Activation	activation	NN
cord-275433-58unu79x	334	39	of	of	IN
cord-275433-58unu79x	334	40	phosphatidylinositol	phosphatidylinositol	JJ
cord-275433-58unu79x	334	41	3-kinase	3-kinase	CD
cord-275433-58unu79x	334	42	by	by	IN
cord-275433-58unu79x	334	43	interleukin-13	interleukin-13	NNP
cord-275433-58unu79x	334	44	.	.	.
cord-275433-58unu79x	335	1	An	an	DT
cord-275433-58unu79x	335	2	inhibitory	inhibitory	JJ
cord-275433-58unu79x	335	3	signal	signal	NN
cord-275433-58unu79x	335	4	for	for	IN
cord-275433-58unu79x	335	5	inducible	inducible	JJ
cord-275433-58unu79x	335	6	nitric	nitric	JJ
cord-275433-58unu79x	335	7	-	-	HYPH
cord-275433-58unu79x	335	8	oxide	oxide	NN
cord-275433-58unu79x	335	9	synthase	synthase	NN
cord-275433-58unu79x	335	10	expression	expression	NN
cord-275433-58unu79x	335	11	in	in	IN
cord-275433-58unu79x	335	12	epithelial	epithelial	JJ
cord-275433-58unu79x	335	13	cell	cell	NN
cord-275433-58unu79x	335	14	line	line	NN
cord-275433-58unu79x	335	15	HT-29	HT-29	NNP
cord-275433-58unu79x	336	1	The	the	DT
cord-275433-58unu79x	336	2	tumor	tumor	NN
cord-275433-58unu79x	336	3	suppressor	suppressor	NN
cord-275433-58unu79x	336	4	PTEN	PTEN	NNP
cord-275433-58unu79x	336	5	positively	positively	RB
cord-275433-58unu79x	336	6	regulates	regulate	VBZ
cord-275433-58unu79x	336	7	macroautophagy	macroautophagy	NNS
cord-275433-58unu79x	336	8	by	by	IN
cord-275433-58unu79x	336	9	inhibiting	inhibit	VBG
cord-275433-58unu79x	336	10	the	the	DT
cord-275433-58unu79x	336	11	phosphatidylinositol	phosphatidylinositol	JJ
cord-275433-58unu79x	336	12	3-kinase	3-kinase	CD
cord-275433-58unu79x	336	13	/	/	SYM
cord-275433-58unu79x	336	14	protein	protein	NN
cord-275433-58unu79x	336	15	kinase	kinase	NN
cord-275433-58unu79x	336	16	B	B	NNP
cord-275433-58unu79x	336	17	pathway	pathway	NN
cord-275433-58unu79x	336	18	Distinct	distinct	JJ
cord-275433-58unu79x	336	19	classes	class	NNS
cord-275433-58unu79x	336	20	of	of	IN
cord-275433-58unu79x	336	21	phosphatidylinositol	phosphatidylinositol	JJ
cord-275433-58unu79x	336	22	3′-kinases	3′-kinases	CD
cord-275433-58unu79x	336	23	are	be	VBP
cord-275433-58unu79x	336	24	involved	involve	VBN
cord-275433-58unu79x	336	25	in	in	IN
cord-275433-58unu79x	336	26	signaling	signal	VBG
cord-275433-58unu79x	336	27	pathways	pathway	NNS
cord-275433-58unu79x	336	28	that	that	WDT
cord-275433-58unu79x	336	29	control	control	VBP
cord-275433-58unu79x	336	30	macroautophagy	macroautophagy	NNS
cord-275433-58unu79x	336	31	in	in	IN
cord-275433-58unu79x	336	32	HT-29	HT-29	NNP
cord-275433-58unu79x	336	33	cells	cell	NNS
cord-275433-58unu79x	337	1	Molecular	molecular	JJ
cord-275433-58unu79x	337	2	mechanisms	mechanism	NNS
cord-275433-58unu79x	337	3	of	of	IN
cord-275433-58unu79x	337	4	interferon	interferon	NN
cord-275433-58unu79x	337	5	resistance	resistance	NN
cord-275433-58unu79x	337	6	mediated	mediate	VBN
cord-275433-58unu79x	337	7	by	by	IN
cord-275433-58unu79x	337	8	viral	viral	RB
cord-275433-58unu79x	337	9	-	-	HYPH
cord-275433-58unu79x	337	10	directed	direct	VBN
cord-275433-58unu79x	337	11	inhibition	inhibition	NN
cord-275433-58unu79x	337	12	of	of	IN
cord-275433-58unu79x	337	13	PKR	PKR	NNP
cord-275433-58unu79x	337	14	,	,	,
cord-275433-58unu79x	337	15	the	the	DT
cord-275433-58unu79x	337	16	interferon	interferon	NN
cord-275433-58unu79x	337	17	-	-	HYPH
cord-275433-58unu79x	337	18	induced	induce	VBN
cord-275433-58unu79x	337	19	protein	protein	NN
cord-275433-58unu79x	337	20	kinase	kinase	NN
cord-275433-58unu79x	337	21	Autophagy	Autophagy	NNP
cord-275433-58unu79x	337	22	is	be	VBZ
cord-275433-58unu79x	337	23	an	an	DT
cord-275433-58unu79x	337	24	effector	effector	NN
cord-275433-58unu79x	337	25	of	of	IN
cord-275433-58unu79x	337	26	Th1-Th2	Th1-Th2	NNP
cord-275433-58unu79x	337	27	polarization	polarization	NN
cord-275433-58unu79x	337	28	:	:	:
cord-275433-58unu79x	337	29	Th2	th2	CD
cord-275433-58unu79x	337	30	cytokines	cytokine	NNS
cord-275433-58unu79x	337	31	inhibit	inhibit	VBP
cord-275433-58unu79x	337	32	autophagic	autophagic	JJ
cord-275433-58unu79x	337	33	control	control	NN
cord-275433-58unu79x	337	34	of	of	IN
cord-275433-58unu79x	337	35	intracellular	intracellular	JJ
cord-275433-58unu79x	337	36	Mycobacterium	Mycobacterium	NNP
cord-275433-58unu79x	337	37	tuberculosis	tuberculosis	NN
cord-275433-58unu79x	337	38	p47	p47	CD
cord-275433-58unu79x	337	39	GTPases	gtpase	NNS
cord-275433-58unu79x	337	40	:	:	:
cord-275433-58unu79x	338	1	regulators	regulator	NNS
cord-275433-58unu79x	338	2	of	of	IN
cord-275433-58unu79x	338	3	immunity	immunity	NN
cord-275433-58unu79x	338	4	to	to	IN
cord-275433-58unu79x	338	5	intracellular	intracellular	JJ
cord-275433-58unu79x	338	6	pathogens	pathogen	NNS
cord-275433-58unu79x	338	7	Autophagy	Autophagy	NNP
cord-275433-58unu79x	338	8	in	in	IN
cord-275433-58unu79x	338	9	cell	cell	NN
cord-275433-58unu79x	338	10	death	death	NN
cord-275433-58unu79x	338	11	:	:	:
cord-275433-58unu79x	338	12	an	an	DT
cord-275433-58unu79x	338	13	innocent	innocent	JJ
cord-275433-58unu79x	338	14	convict	convict	NN
cord-275433-58unu79x	338	15	?	?	.
cord-275433-58unu79x	339	1	Autophagy	Autophagy	NNP
cord-275433-58unu79x	339	2	:	:	:
cord-275433-58unu79x	339	3	paying	pay	VBG
cord-275433-58unu79x	339	4	Charon	Charon	NNP
cord-275433-58unu79x	339	5	's	's	POS
cord-275433-58unu79x	339	6	toll	toll	NN
cord-275433-58unu79x	339	7	Autophagy	Autophagy	NNP
cord-275433-58unu79x	339	8	is	be	VBZ
cord-275433-58unu79x	339	9	involved	involve	VBN
cord-275433-58unu79x	339	10	in	in	IN
cord-275433-58unu79x	339	11	T	T	NNP
cord-275433-58unu79x	339	12	cell	cell	NN
cord-275433-58unu79x	339	13	death	death	NN
cord-275433-58unu79x	339	14	after	after	IN
cord-275433-58unu79x	339	15	binding	bind	VBG
cord-275433-58unu79x	339	16	of	of	IN
cord-275433-58unu79x	339	17	HIV-1	HIV-1	NNP
cord-275433-58unu79x	339	18	envelope	envelope	NN
cord-275433-58unu79x	339	19	proteins	protein	NNS
cord-275433-58unu79x	339	20	to	to	IN
cord-275433-58unu79x	339	21	CXCR4	cxcr4	XX
cord-275433-58unu79x	339	22	Phagocytosis	Phagocytosis	NNP
cord-275433-58unu79x	339	23	of	of	IN
cord-275433-58unu79x	339	24	apoptotic	apoptotic	JJ
cord-275433-58unu79x	339	25	cells	cell	NNS
cord-275433-58unu79x	339	26	and	and	CC
cord-275433-58unu79x	339	27	the	the	DT
cord-275433-58unu79x	339	28	resolution	resolution	NN
cord-275433-58unu79x	339	29	of	of	IN
cord-275433-58unu79x	339	30	inflammation	inflammation	NN
cord-275433-58unu79x	339	31	Removal	removal	NN
cord-275433-58unu79x	339	32	of	of	IN
cord-275433-58unu79x	339	33	dying	die	VBG
cord-275433-58unu79x	339	34	cells	cell	NNS
cord-275433-58unu79x	339	35	and	and	CC
cord-275433-58unu79x	339	36	systemic	systemic	JJ
cord-275433-58unu79x	339	37	lupus	lupus	NN
cord-275433-58unu79x	340	1	erythematosus	erythematosus	NN
cord-275433-58unu79x	341	1	Inefficient	inefficient	JJ
cord-275433-58unu79x	341	2	clearance	clearance	NN
cord-275433-58unu79x	341	3	of	of	IN
cord-275433-58unu79x	341	4	dying	die	VBG
cord-275433-58unu79x	341	5	cells	cell	NNS
cord-275433-58unu79x	341	6	and	and	CC
cord-275433-58unu79x	341	7	autoreactivity	autoreactivity	NN
cord-275433-58unu79x	341	8	Mechanisms	Mechanisms	NNPS
cord-275433-58unu79x	341	9	of	of	IN
cord-275433-58unu79x	341	10	disease	disease	NN
cord-275433-58unu79x	341	11	pathogenesis	pathogenesis	NN
cord-275433-58unu79x	341	12	:	:	:
cord-275433-58unu79x	342	1	pathogenesis	pathogenesis	NN
cord-275433-58unu79x	342	2	of	of	IN
cord-275433-58unu79x	342	3	Crohn	Crohn	NNP
cord-275433-58unu79x	342	4	's	's	POS
cord-275433-58unu79x	342	5	disease	disease	NN
cord-275433-58unu79x	342	6	and	and	CC
cord-275433-58unu79x	342	7	ulcerative	ulcerative	JJ
cord-275433-58unu79x	342	8	colitis	colitis	NN
cord-275433-58unu79x	342	9	Inflammatory	inflammatory	JJ
cord-275433-58unu79x	342	10	bowel	bowel	NN
cord-275433-58unu79x	342	11	disease	disease	NN
cord-275433-58unu79x	342	12	:	:	:
cord-275433-58unu79x	342	13	cause	cause	VB
cord-275433-58unu79x	342	14	and	and	CC
cord-275433-58unu79x	342	15	immunobiology	immunobiology	NN
cord-275433-58unu79x	343	1	Toll	toll	NN
cord-275433-58unu79x	343	2	-	-	HYPH
cord-275433-58unu79x	343	3	like	like	JJ
cord-275433-58unu79x	343	4	receptor	receptor	NN
cord-275433-58unu79x	343	5	4	4	CD
cord-275433-58unu79x	343	6	is	be	VBZ
cord-275433-58unu79x	343	7	a	a	DT
cord-275433-58unu79x	343	8	sensor	sensor	NN
cord-275433-58unu79x	343	9	for	for	IN
cord-275433-58unu79x	343	10	autophagy	autophagy	NN
cord-275433-58unu79x	343	11	associated	associate	VBN
cord-275433-58unu79x	343	12	with	with	IN
cord-275433-58unu79x	343	13	innate	innate	JJ
cord-275433-58unu79x	343	14	immunity	immunity	NN
cord-275433-58unu79x	344	1	The	the	DT
cord-275433-58unu79x	344	2	original	original	JJ
cord-275433-58unu79x	344	3	work	work	NN
cord-275433-58unu79x	344	4	from	from	IN
cord-275433-58unu79x	344	5	the	the	DT
cord-275433-58unu79x	344	6	authors	author	NNS
cord-275433-58unu79x	344	7	'	'	POS
cord-275433-58unu79x	344	8	laboratories	laboratory	NNS
cord-275433-58unu79x	344	9	was	be	VBD
cord-275433-58unu79x	344	10	supported	support	VBN
cord-275433-58unu79x	344	11	by	by	IN
cord-275433-58unu79x	344	12	the	the	DT
cord-275433-58unu79x	344	13	National	National	NNP
cord-275433-58unu79x	344	14	Institutes	Institutes	NNPS
cord-275433-58unu79x	344	15	of	of	IN
cord-275433-58unu79x	344	16	Health	Health	NNP
cord-275433-58unu79x	344	17	,	,	,
cord-275433-58unu79x	344	18	USA	USA	NNP
cord-275433-58unu79x	344	19	(	(	-LRB-
cord-275433-58unu79x	344	20	V.D.	V.D.	NNP
cord-275433-58unu79x	344	21	and	and	CC
cord-275433-58unu79x	344	22	B.L.	B.L.	NNP
cord-275433-58unu79x	344	23	)	)	-RRB-
cord-275433-58unu79x	344	24	and	and	CC
cord-275433-58unu79x	344	25	the	the	DT
cord-275433-58unu79x	344	26	Ellison	Ellison	NNP
cord-275433-58unu79x	344	27	Medical	Medical	NNP
cord-275433-58unu79x	344	28	Foundation	Foundation	NNP
cord-275433-58unu79x	344	29	(	(	-LRB-
cord-275433-58unu79x	344	30	B.L.	B.L.	NNP
cord-275433-58unu79x	344	31	)	)	-RRB-
cord-275433-58unu79x	344	32	.	.	.
cord-275433-58unu79x	345	1	The	the	DT
cord-275433-58unu79x	345	2	authors	author	NNS
cord-275433-58unu79x	345	3	declare	declare	VBP
cord-275433-58unu79x	345	4	no	no	DT
cord-275433-58unu79x	345	5	competing	compete	VBG
cord-275433-58unu79x	345	6	financial	financial	JJ
cord-275433-58unu79x	345	7	interests	interest	NNS
cord-275433-58unu79x	345	8	.	.	.
cord-275433-58unu79x	345	9	 	 	_SP