id	sid	tid	token	lemma	pos
cord-285091-2i2v5ecg	1	1	key	key	JJ
cord-285091-2i2v5ecg	1	2	:	:	:
cord-285091-2i2v5ecg	1	3	cord-285091	cord-285091	JJ
cord-285091-2i2v5ecg	1	4	-	-	HYPH
cord-285091-2i2v5ecg	1	5	2i2v5ecg	2i2v5ecg	JJ
cord-285091-2i2v5ecg	1	6	authors	author	NNS
cord-285091-2i2v5ecg	1	7	:	:	:
cord-285091-2i2v5ecg	1	8	Kopitar	Kopitar	NNP
cord-285091-2i2v5ecg	1	9	-	-	HYPH
cord-285091-2i2v5ecg	1	10	Jerala	Jerala	NNP
cord-285091-2i2v5ecg	1	11	,	,	,
cord-285091-2i2v5ecg	2	1	Nataša	Nataša	NNP
cord-285091-2i2v5ecg	2	2	title	title	NN
cord-285091-2i2v5ecg	2	3	:	:	:
cord-285091-2i2v5ecg	3	1	The	the	DT
cord-285091-2i2v5ecg	3	2	Role	role	NN
cord-285091-2i2v5ecg	3	3	of	of	IN
cord-285091-2i2v5ecg	3	4	Cysteine	Cysteine	NNP
cord-285091-2i2v5ecg	3	5	Proteinases	Proteinases	NNP
cord-285091-2i2v5ecg	3	6	and	and	CC
cord-285091-2i2v5ecg	3	7	their	-PRON-	PRP$
cord-285091-2i2v5ecg	3	8	Inhibitors	Inhibitors	NNPS
cord-285091-2i2v5ecg	3	9	in	in	IN
cord-285091-2i2v5ecg	3	10	the	the	DT
cord-285091-2i2v5ecg	3	11	Host	Host	NNP
cord-285091-2i2v5ecg	3	12	-	-	HYPH
cord-285091-2i2v5ecg	3	13	Pathogen	Pathogen	NNP
cord-285091-2i2v5ecg	3	14	Cross	Cross	NNP
cord-285091-2i2v5ecg	3	15	Talk	Talk	NNP
cord-285091-2i2v5ecg	3	16	date	date	NN
cord-285091-2i2v5ecg	3	17	:	:	:
cord-285091-2i2v5ecg	3	18	2012	2012	CD
cord-285091-2i2v5ecg	3	19	-	-	SYM
cord-285091-2i2v5ecg	3	20	12	12	CD
cord-285091-2i2v5ecg	3	21	-	-	SYM
cord-285091-2i2v5ecg	3	22	17	17	CD
cord-285091-2i2v5ecg	3	23	journal	journal	NN
cord-285091-2i2v5ecg	3	24	:	:	:
cord-285091-2i2v5ecg	3	25	Curr	Curr	NNP
cord-285091-2i2v5ecg	3	26	Protein	Protein	NNP
cord-285091-2i2v5ecg	3	27	Pept	Pept	NNP
cord-285091-2i2v5ecg	3	28	Sci	Sci	NNP
cord-285091-2i2v5ecg	3	29	DOI	DOI	NNP
cord-285091-2i2v5ecg	3	30	:	:	:
cord-285091-2i2v5ecg	3	31	10.2174/138920312804871102	10.2174/138920312804871102	CD
cord-285091-2i2v5ecg	3	32	sha	sha	NNP
cord-285091-2i2v5ecg	3	33	:	:	:
cord-285091-2i2v5ecg	4	1	54ca96205e785170fff9f439860d4f4fa4d95782	54ca96205e785170fff9f439860d4f4fa4d95782	CD
cord-285091-2i2v5ecg	4	2	doc_id	doc_id	CD
cord-285091-2i2v5ecg	4	3	:	:	:
cord-285091-2i2v5ecg	5	1	285091	285091	CD
cord-285091-2i2v5ecg	5	2	cord_uid	cord_uid	NNS
cord-285091-2i2v5ecg	5	3	:	:	:
cord-285091-2i2v5ecg	6	1	2i2v5ecg	2i2v5ecg	CD
cord-285091-2i2v5ecg	6	2	Proteinases	Proteinases	NNPS
cord-285091-2i2v5ecg	6	3	and	and	CC
cord-285091-2i2v5ecg	6	4	their	-PRON-	PRP$
cord-285091-2i2v5ecg	6	5	inhibitors	inhibitor	NNS
cord-285091-2i2v5ecg	6	6	play	play	VBP
cord-285091-2i2v5ecg	6	7	essential	essential	JJ
cord-285091-2i2v5ecg	6	8	functional	functional	JJ
cord-285091-2i2v5ecg	6	9	roles	role	NNS
cord-285091-2i2v5ecg	6	10	in	in	IN
cord-285091-2i2v5ecg	6	11	basic	basic	JJ
cord-285091-2i2v5ecg	6	12	biological	biological	JJ
cord-285091-2i2v5ecg	6	13	processes	process	NNS
cord-285091-2i2v5ecg	6	14	in	in	IN
cord-285091-2i2v5ecg	6	15	both	both	DT
cord-285091-2i2v5ecg	6	16	hosts	host	NNS
cord-285091-2i2v5ecg	6	17	and	and	CC
cord-285091-2i2v5ecg	6	18	pathogens	pathogen	NNS
cord-285091-2i2v5ecg	6	19	.	.	.
cord-285091-2i2v5ecg	7	1	Endo	endo	NN
cord-285091-2i2v5ecg	7	2	/	/	SYM
cord-285091-2i2v5ecg	7	3	lysosomal	lysosomal	JJ
cord-285091-2i2v5ecg	7	4	cathepsins	cathepsin	NNS
cord-285091-2i2v5ecg	7	5	participate	participate	VBP
cord-285091-2i2v5ecg	7	6	in	in	IN
cord-285091-2i2v5ecg	7	7	immune	immune	JJ
cord-285091-2i2v5ecg	7	8	response	response	NN
cord-285091-2i2v5ecg	7	9	in	in	IN
cord-285091-2i2v5ecg	7	10	pathogen	pathogen	NN
cord-285091-2i2v5ecg	7	11	recognition	recognition	NN
cord-285091-2i2v5ecg	7	12	and	and	CC
cord-285091-2i2v5ecg	7	13	elimination	elimination	NN
cord-285091-2i2v5ecg	7	14	.	.	.
cord-285091-2i2v5ecg	8	1	They	-PRON-	PRP
cord-285091-2i2v5ecg	8	2	are	be	VBP
cord-285091-2i2v5ecg	8	3	essential	essential	JJ
cord-285091-2i2v5ecg	8	4	for	for	IN
cord-285091-2i2v5ecg	8	5	both	both	DT
cord-285091-2i2v5ecg	8	6	antigen	antigen	NN
cord-285091-2i2v5ecg	8	7	processing	processing	NN
cord-285091-2i2v5ecg	8	8	and	and	CC
cord-285091-2i2v5ecg	8	9	presentation	presentation	NN
cord-285091-2i2v5ecg	8	10	(	(	-LRB-
cord-285091-2i2v5ecg	8	11	host	host	NN
cord-285091-2i2v5ecg	8	12	adaptive	adaptive	JJ
cord-285091-2i2v5ecg	8	13	immune	immune	JJ
cord-285091-2i2v5ecg	8	14	response	response	NN
cord-285091-2i2v5ecg	8	15	)	)	-RRB-
cord-285091-2i2v5ecg	8	16	and	and	CC
cord-285091-2i2v5ecg	8	17	activation	activation	NN
cord-285091-2i2v5ecg	8	18	of	of	IN
cord-285091-2i2v5ecg	8	19	endosomal	endosomal	NNP
cord-285091-2i2v5ecg	8	20	Toll	Toll	NNP
cord-285091-2i2v5ecg	8	21	like	like	IN
cord-285091-2i2v5ecg	8	22	receptors	receptor	NNS
cord-285091-2i2v5ecg	8	23	(	(	-LRB-
cord-285091-2i2v5ecg	8	24	innate	innate	JJ
cord-285091-2i2v5ecg	8	25	immune	immune	JJ
cord-285091-2i2v5ecg	8	26	response	response	NN
cord-285091-2i2v5ecg	8	27	)	)	-RRB-
cord-285091-2i2v5ecg	8	28	.	.	.
cord-285091-2i2v5ecg	9	1	Pathogens	pathogen	NNS
cord-285091-2i2v5ecg	9	2	can	can	MD
cord-285091-2i2v5ecg	9	3	produce	produce	VB
cord-285091-2i2v5ecg	9	4	proteases	protease	NNS
cord-285091-2i2v5ecg	9	5	and	and	CC
cord-285091-2i2v5ecg	9	6	also	also	RB
cord-285091-2i2v5ecg	9	7	natural	natural	JJ
cord-285091-2i2v5ecg	9	8	inhibitors	inhibitor	NNS
cord-285091-2i2v5ecg	9	9	to	to	TO
cord-285091-2i2v5ecg	9	10	subvert	subvert	VB
cord-285091-2i2v5ecg	9	11	the	the	DT
cord-285091-2i2v5ecg	9	12	host	host	NN
cord-285091-2i2v5ecg	9	13	immune	immune	JJ
cord-285091-2i2v5ecg	9	14	response	response	NN
cord-285091-2i2v5ecg	9	15	.	.	.
cord-285091-2i2v5ecg	10	1	Several	several	JJ
cord-285091-2i2v5ecg	10	2	pathogens	pathogen	NNS
cord-285091-2i2v5ecg	10	3	are	be	VBP
cord-285091-2i2v5ecg	10	4	sensed	sense	VBN
cord-285091-2i2v5ecg	10	5	through	through	IN
cord-285091-2i2v5ecg	10	6	the	the	DT
cord-285091-2i2v5ecg	10	7	intracellular	intracellular	JJ
cord-285091-2i2v5ecg	10	8	pathogen	pathogen	NN
cord-285091-2i2v5ecg	10	9	recognition	recognition	NN
cord-285091-2i2v5ecg	10	10	receptors	receptor	NNS
cord-285091-2i2v5ecg	10	11	,	,	,
cord-285091-2i2v5ecg	10	12	but	but	CC
cord-285091-2i2v5ecg	10	13	only	only	RB
cord-285091-2i2v5ecg	10	14	some	some	DT
cord-285091-2i2v5ecg	10	15	of	of	IN
cord-285091-2i2v5ecg	10	16	them	-PRON-	PRP
cord-285091-2i2v5ecg	10	17	use	use	VBP
cord-285091-2i2v5ecg	10	18	the	the	DT
cord-285091-2i2v5ecg	10	19	host	host	NN
cord-285091-2i2v5ecg	10	20	proteolytic	proteolytic	JJ
cord-285091-2i2v5ecg	10	21	system	system	NN
cord-285091-2i2v5ecg	10	22	to	to	TO
cord-285091-2i2v5ecg	10	23	escape	escape	VB
cord-285091-2i2v5ecg	10	24	into	into	IN
cord-285091-2i2v5ecg	10	25	the	the	DT
cord-285091-2i2v5ecg	10	26	cytosol	cytosol	NN
cord-285091-2i2v5ecg	10	27	.	.	.
cord-285091-2i2v5ecg	11	1	In	in	IN
cord-285091-2i2v5ecg	11	2	this	this	DT
cord-285091-2i2v5ecg	11	3	review	review	NN
cord-285091-2i2v5ecg	11	4	,	,	,
cord-285091-2i2v5ecg	11	5	I	-PRON-	PRP
cord-285091-2i2v5ecg	11	6	provide	provide	VBP
cord-285091-2i2v5ecg	11	7	an	an	DT
cord-285091-2i2v5ecg	11	8	update	update	NN
cord-285091-2i2v5ecg	11	9	on	on	IN
cord-285091-2i2v5ecg	11	10	the	the	DT
cord-285091-2i2v5ecg	11	11	most	most	RBS
cord-285091-2i2v5ecg	11	12	recent	recent	JJ
cord-285091-2i2v5ecg	11	13	developments	development	NNS
cord-285091-2i2v5ecg	11	14	regarding	regard	VBG
cord-285091-2i2v5ecg	11	15	the	the	DT
cord-285091-2i2v5ecg	11	16	role	role	NN
cord-285091-2i2v5ecg	11	17	of	of	IN
cord-285091-2i2v5ecg	11	18	proteinases	proteinases	NNP
cord-285091-2i2v5ecg	11	19	and	and	CC
cord-285091-2i2v5ecg	11	20	their	-PRON-	PRP$
cord-285091-2i2v5ecg	11	21	inhibitors	inhibitor	NNS
cord-285091-2i2v5ecg	11	22	in	in	IN
cord-285091-2i2v5ecg	11	23	the	the	DT
cord-285091-2i2v5ecg	11	24	initiation	initiation	NN
cord-285091-2i2v5ecg	11	25	and	and	CC
cord-285091-2i2v5ecg	11	26	regulation	regulation	NN
cord-285091-2i2v5ecg	11	27	of	of	IN
cord-285091-2i2v5ecg	11	28	immune	immune	JJ
cord-285091-2i2v5ecg	11	29	responses	response	NNS
cord-285091-2i2v5ecg	11	30	.	.	.
cord-285091-2i2v5ecg	12	1	Multicellular	multicellular	JJ
cord-285091-2i2v5ecg	12	2	organisms	organism	NNS
cord-285091-2i2v5ecg	12	3	have	have	VBP
cord-285091-2i2v5ecg	12	4	continuous	continuous	JJ
cord-285091-2i2v5ecg	12	5	interactions	interaction	NNS
cord-285091-2i2v5ecg	12	6	with	with	IN
cord-285091-2i2v5ecg	12	7	both	both	CC
cord-285091-2i2v5ecg	12	8	pathogenic	pathogenic	JJ
cord-285091-2i2v5ecg	12	9	and	and	CC
cord-285091-2i2v5ecg	12	10	non	non	JJ
cord-285091-2i2v5ecg	12	11	-	-	JJ
cord-285091-2i2v5ecg	12	12	pathogenic	pathogenic	JJ
cord-285091-2i2v5ecg	12	13	microbes	microbe	NNS
cord-285091-2i2v5ecg	12	14	and	and	CC
cord-285091-2i2v5ecg	12	15	have	have	VBP
cord-285091-2i2v5ecg	12	16	developed	develop	VBN
cord-285091-2i2v5ecg	12	17	a	a	DT
cord-285091-2i2v5ecg	12	18	set	set	NN
cord-285091-2i2v5ecg	12	19	of	of	IN
cord-285091-2i2v5ecg	12	20	antimicrobial	antimicrobial	JJ
cord-285091-2i2v5ecg	12	21	recognition	recognition	NN
cord-285091-2i2v5ecg	12	22	and	and	CC
cord-285091-2i2v5ecg	12	23	defense	defense	NN
cord-285091-2i2v5ecg	12	24	systems	system	NNS
cord-285091-2i2v5ecg	12	25	,	,	,
cord-285091-2i2v5ecg	12	26	which	which	WDT
cord-285091-2i2v5ecg	12	27	enable	enable	VBP
cord-285091-2i2v5ecg	12	28	them	-PRON-	PRP
cord-285091-2i2v5ecg	12	29	to	to	TO
cord-285091-2i2v5ecg	12	30	survive	survive	VB
cord-285091-2i2v5ecg	12	31	.	.	.
cord-285091-2i2v5ecg	13	1	The	the	DT
cord-285091-2i2v5ecg	13	2	innate	innate	JJ
cord-285091-2i2v5ecg	13	3	immune	immune	JJ
cord-285091-2i2v5ecg	13	4	system	system	NN
cord-285091-2i2v5ecg	13	5	detects	detect	VBZ
cord-285091-2i2v5ecg	13	6	molecular	molecular	JJ
cord-285091-2i2v5ecg	13	7	structures	structure	NNS
cord-285091-2i2v5ecg	13	8	,	,	,
cord-285091-2i2v5ecg	13	9	denoted	denote	VBN
cord-285091-2i2v5ecg	13	10	as	as	IN
cord-285091-2i2v5ecg	13	11	pathogen	pathogen	NN
cord-285091-2i2v5ecg	13	12	associated	associate	VBD
cord-285091-2i2v5ecg	13	13	molecular	molecular	JJ
cord-285091-2i2v5ecg	13	14	patterns	pattern	NNS
cord-285091-2i2v5ecg	13	15	(	(	-LRB-
cord-285091-2i2v5ecg	13	16	PAMPs	pamp	NNS
cord-285091-2i2v5ecg	13	17	)	)	-RRB-
cord-285091-2i2v5ecg	13	18	that	that	WDT
cord-285091-2i2v5ecg	13	19	are	be	VBP
cord-285091-2i2v5ecg	13	20	distinct	distinct	JJ
cord-285091-2i2v5ecg	13	21	from	from	IN
cord-285091-2i2v5ecg	13	22	host	host	NN
cord-285091-2i2v5ecg	13	23	molecular	molecular	JJ
cord-285091-2i2v5ecg	13	24	pattern	pattern	NN
cord-285091-2i2v5ecg	13	25	and	and	CC
cord-285091-2i2v5ecg	13	26	are	be	VBP
cord-285091-2i2v5ecg	13	27	frequently	frequently	RB
cord-285091-2i2v5ecg	13	28	found	find	VBN
cord-285091-2i2v5ecg	13	29	in	in	IN
cord-285091-2i2v5ecg	13	30	bacteria	bacteria	NNS
cord-285091-2i2v5ecg	13	31	,	,	,
cord-285091-2i2v5ecg	13	32	fungi	fungus	NNS
cord-285091-2i2v5ecg	13	33	,	,	,
cord-285091-2i2v5ecg	13	34	virus	virus	NN
cord-285091-2i2v5ecg	13	35	,	,	,
cord-285091-2i2v5ecg	13	36	and	and	CC
cord-285091-2i2v5ecg	13	37	some	some	DT
cord-285091-2i2v5ecg	13	38	protozoans	protozoan	NNS
cord-285091-2i2v5ecg	13	39	.	.	.
cord-285091-2i2v5ecg	14	1	These	these	DT
cord-285091-2i2v5ecg	14	2	PAMPs	pamp	NNS
cord-285091-2i2v5ecg	14	3	are	be	VBP
cord-285091-2i2v5ecg	14	4	detected	detect	VBN
cord-285091-2i2v5ecg	14	5	using	use	VBG
cord-285091-2i2v5ecg	14	6	an	an	DT
cord-285091-2i2v5ecg	14	7	array	array	NN
cord-285091-2i2v5ecg	14	8	of	of	IN
cord-285091-2i2v5ecg	14	9	pattern	pattern	NN
cord-285091-2i2v5ecg	14	10	-	-	HYPH
cord-285091-2i2v5ecg	14	11	recognition	recognition	NN
cord-285091-2i2v5ecg	14	12	receptors	receptor	NNS
cord-285091-2i2v5ecg	14	13	(	(	-LRB-
cord-285091-2i2v5ecg	14	14	PRRs	PRRs	NNP
cord-285091-2i2v5ecg	14	15	)	)	-RRB-
cord-285091-2i2v5ecg	14	16	[	[	-LRB-
cord-285091-2i2v5ecg	14	17	1	1	CD
cord-285091-2i2v5ecg	14	18	]	]	-RRB-
cord-285091-2i2v5ecg	14	19	[	[	-LRB-
cord-285091-2i2v5ecg	14	20	2	2	CD
cord-285091-2i2v5ecg	14	21	]	]	-RRB-
cord-285091-2i2v5ecg	14	22	[	[	-LRB-
cord-285091-2i2v5ecg	14	23	3	3	CD
cord-285091-2i2v5ecg	14	24	]	]	-RRB-
cord-285091-2i2v5ecg	14	25	,	,	,
cord-285091-2i2v5ecg	14	26	which	which	WDT
cord-285091-2i2v5ecg	14	27	are	be	VBP
cord-285091-2i2v5ecg	14	28	expressed	express	VBN
cord-285091-2i2v5ecg	14	29	at	at	IN
cord-285091-2i2v5ecg	14	30	the	the	DT
cord-285091-2i2v5ecg	14	31	first	first	JJ
cord-285091-2i2v5ecg	14	32	line	line	NN
cord-285091-2i2v5ecg	14	33	of	of	IN
cord-285091-2i2v5ecg	14	34	defense	defense	NN
cord-285091-2i2v5ecg	14	35	against	against	IN
cord-285091-2i2v5ecg	14	36	infection	infection	NN
cord-285091-2i2v5ecg	14	37	by	by	IN
cord-285091-2i2v5ecg	14	38	cells	cell	NNS
cord-285091-2i2v5ecg	14	39	like	like	IN
cord-285091-2i2v5ecg	14	40	macrophages	macrophage	NNS
cord-285091-2i2v5ecg	14	41	,	,	,
cord-285091-2i2v5ecg	14	42	monocytes	monocyte	NNS
cord-285091-2i2v5ecg	14	43	,	,	,
cord-285091-2i2v5ecg	14	44	dendritic	dendritic	JJ
cord-285091-2i2v5ecg	14	45	cells	cell	NNS
cord-285091-2i2v5ecg	14	46	,	,	,
cord-285091-2i2v5ecg	14	47	neutrophils	neutrophil	NNS
cord-285091-2i2v5ecg	14	48	and	and	CC
cord-285091-2i2v5ecg	14	49	epithelial	epithelial	JJ
cord-285091-2i2v5ecg	14	50	cells	cell	NNS
cord-285091-2i2v5ecg	14	51	,	,	,
cord-285091-2i2v5ecg	14	52	as	as	RB
cord-285091-2i2v5ecg	14	53	well	well	RB
cord-285091-2i2v5ecg	14	54	as	as	IN
cord-285091-2i2v5ecg	14	55	cells	cell	NNS
cord-285091-2i2v5ecg	14	56	of	of	IN
cord-285091-2i2v5ecg	14	57	the	the	DT
cord-285091-2i2v5ecg	14	58	adaptive	adaptive	JJ
cord-285091-2i2v5ecg	14	59	immune	immune	JJ
cord-285091-2i2v5ecg	14	60	system	system	NN
cord-285091-2i2v5ecg	14	61	[	[	-LRB-
cord-285091-2i2v5ecg	14	62	3	3	CD
cord-285091-2i2v5ecg	14	63	]	]	-RRB-
cord-285091-2i2v5ecg	14	64	.	.	.
cord-285091-2i2v5ecg	15	1	PRRs	prr	NNS
cord-285091-2i2v5ecg	15	2	include	include	VBP
cord-285091-2i2v5ecg	15	3	the	the	DT
cord-285091-2i2v5ecg	15	4	membranebound	membranebound	NNP
cord-285091-2i2v5ecg	15	5	Toll	Toll	NNP
cord-285091-2i2v5ecg	15	6	-	-	HYPH
cord-285091-2i2v5ecg	15	7	like	like	JJ
cord-285091-2i2v5ecg	15	8	receptors	receptor	NNS
cord-285091-2i2v5ecg	15	9	(	(	-LRB-
cord-285091-2i2v5ecg	15	10	TLRs	TLRs	NNP
cord-285091-2i2v5ecg	15	11	)	)	-RRB-
cord-285091-2i2v5ecg	15	12	,	,	,
cord-285091-2i2v5ecg	15	13	the	the	DT
cord-285091-2i2v5ecg	15	14	cytosolic	cytosolic	JJ
cord-285091-2i2v5ecg	15	15	NOD	nod	NN
cord-285091-2i2v5ecg	15	16	like	like	IN
cord-285091-2i2v5ecg	15	17	receptors	receptor	NNS
cord-285091-2i2v5ecg	15	18	(	(	-LRB-
cord-285091-2i2v5ecg	15	19	NLRs	NLRs	NNP
cord-285091-2i2v5ecg	15	20	)	)	-RRB-
cord-285091-2i2v5ecg	15	21	and	and	CC
cord-285091-2i2v5ecg	15	22	the	the	DT
cord-285091-2i2v5ecg	15	23	RNA	RNA	NNP
cord-285091-2i2v5ecg	15	24	-	-	HYPH
cord-285091-2i2v5ecg	15	25	sensing	sense	VBG
cord-285091-2i2v5ecg	15	26	RIG	rig	NN
cord-285091-2i2v5ecg	15	27	-	-	HYPH
cord-285091-2i2v5ecg	15	28	like	like	JJ
cord-285091-2i2v5ecg	15	29	helicases	helicase	NNS
cord-285091-2i2v5ecg	15	30	(	(	-LRB-
cord-285091-2i2v5ecg	15	31	RLHs	RLHs	NNPS
cord-285091-2i2v5ecg	15	32	)	)	-RRB-
cord-285091-2i2v5ecg	15	33	[	[	-LRB-
cord-285091-2i2v5ecg	15	34	3	3	CD
cord-285091-2i2v5ecg	15	35	]	]	-RRB-
cord-285091-2i2v5ecg	15	36	.	.	.
cord-285091-2i2v5ecg	16	1	The	the	DT
cord-285091-2i2v5ecg	16	2	outcome	outcome	NN
cord-285091-2i2v5ecg	16	3	of	of	IN
cord-285091-2i2v5ecg	16	4	PAMP	PAMP	NNP
cord-285091-2i2v5ecg	16	5	recognition	recognition	NN
cord-285091-2i2v5ecg	16	6	by	by	IN
cord-285091-2i2v5ecg	16	7	PRRs	PRRs	NNP
cord-285091-2i2v5ecg	16	8	leads	lead	VBZ
cord-285091-2i2v5ecg	16	9	to	to	TO
cord-285091-2i2v5ecg	16	10	signal	signal	VB
cord-285091-2i2v5ecg	16	11	transduction	transduction	NN
cord-285091-2i2v5ecg	16	12	from	from	IN
cord-285091-2i2v5ecg	16	13	these	these	DT
cord-285091-2i2v5ecg	16	14	receptors	receptor	NNS
cord-285091-2i2v5ecg	16	15	which	which	WDT
cord-285091-2i2v5ecg	16	16	converges	converge	VBZ
cord-285091-2i2v5ecg	16	17	on	on	IN
cord-285091-2i2v5ecg	16	18	a	a	DT
cord-285091-2i2v5ecg	16	19	common	common	JJ
cord-285091-2i2v5ecg	16	20	set	set	NN
cord-285091-2i2v5ecg	16	21	of	of	IN
cord-285091-2i2v5ecg	16	22	signaling	signal	VBG
cord-285091-2i2v5ecg	16	23	modules	module	NNS
cord-285091-2i2v5ecg	16	24	,	,	,
cord-285091-2i2v5ecg	16	25	often	often	RB
cord-285091-2i2v5ecg	16	26	including	include	VBG
cord-285091-2i2v5ecg	16	27	the	the	DT
cord-285091-2i2v5ecg	16	28	activation	activation	NN
cord-285091-2i2v5ecg	16	29	of	of	IN
cord-285091-2i2v5ecg	16	30	the	the	DT
cord-285091-2i2v5ecg	16	31	NF	nf	NN
cord-285091-2i2v5ecg	16	32	-	-	HYPH
cord-285091-2i2v5ecg	16	33	B	B	NNP
cord-285091-2i2v5ecg	16	34	and	and	CC
cord-285091-2i2v5ecg	16	35	AP-1	AP-1	NNP
cord-285091-2i2v5ecg	16	36	transcription	transcription	NN
cord-285091-2i2v5ecg	16	37	factors	factor	NNS
cord-285091-2i2v5ecg	16	38	that	that	WDT
cord-285091-2i2v5ecg	16	39	drive	drive	VBP
cord-285091-2i2v5ecg	16	40	proinflammatory	proinflammatory	JJ
cord-285091-2i2v5ecg	16	41	cytokine	cytokine	NN
cord-285091-2i2v5ecg	16	42	/	/	SYM
cord-285091-2i2v5ecg	16	43	chemokine	chemokine	NN
cord-285091-2i2v5ecg	16	44	production	production	NN
cord-285091-2i2v5ecg	16	45	[	[	-LRB-
cord-285091-2i2v5ecg	16	46	4	4	CD
cord-285091-2i2v5ecg	16	47	,	,	,
cord-285091-2i2v5ecg	16	48	5	5	CD
cord-285091-2i2v5ecg	16	49	]	]	-RRB-
cord-285091-2i2v5ecg	16	50	.	.	.
cord-285091-2i2v5ecg	17	1	Ligand	ligand	NN
cord-285091-2i2v5ecg	17	2	recognition	recognition	NN
cord-285091-2i2v5ecg	17	3	by	by	IN
cord-285091-2i2v5ecg	17	4	TLRs	TLRs	NNP
cord-285091-2i2v5ecg	17	5	is	be	VBZ
cord-285091-2i2v5ecg	17	6	mediated	mediate	VBN
cord-285091-2i2v5ecg	17	7	by	by	IN
cord-285091-2i2v5ecg	17	8	the	the	DT
cord-285091-2i2v5ecg	17	9	extracellular	extracellular	JJ
cord-285091-2i2v5ecg	17	10	or	or	CC
cord-285091-2i2v5ecg	17	11	ectodomains	ectodomain	NNS
cord-285091-2i2v5ecg	17	12	that	that	WDT
cord-285091-2i2v5ecg	17	13	contain	contain	VBP
cord-285091-2i2v5ecg	17	14	19	19	CD
cord-285091-2i2v5ecg	17	15	to	to	TO
cord-285091-2i2v5ecg	17	16	25	25	CD
cord-285091-2i2v5ecg	17	17	leucine	leucine	NN
cord-285091-2i2v5ecg	17	18	-	-	HYPH
cord-285091-2i2v5ecg	17	19	rich	rich	JJ
cord-285091-2i2v5ecg	17	20	repeat	repeat	NN
cord-285091-2i2v5ecg	17	21	(	(	-LRB-
cord-285091-2i2v5ecg	17	22	LRR	LRR	NNP
cord-285091-2i2v5ecg	17	23	)	)	-RRB-
cord-285091-2i2v5ecg	17	24	motifs	motif	NNS
cord-285091-2i2v5ecg	17	25	,	,	,
cord-285091-2i2v5ecg	17	26	a	a	DT
cord-285091-2i2v5ecg	17	27	transmembrane	transmembrane	NN
cord-285091-2i2v5ecg	17	28	domain	domain	NN
cord-285091-2i2v5ecg	17	29	and	and	CC
cord-285091-2i2v5ecg	17	30	a	a	DT
cord-285091-2i2v5ecg	17	31	cytoplasmic	cytoplasmic	JJ
cord-285091-2i2v5ecg	17	32	TIR	TIR	NNP
cord-285091-2i2v5ecg	17	33	domain	domain	NN
cord-285091-2i2v5ecg	17	34	[	[	-LRB-
cord-285091-2i2v5ecg	17	35	6	6	CD
cord-285091-2i2v5ecg	17	36	]	]	-RRB-
cord-285091-2i2v5ecg	18	1	[	[	-LRB-
cord-285091-2i2v5ecg	18	2	7	7	CD
cord-285091-2i2v5ecg	18	3	]	]	-RRB-
cord-285091-2i2v5ecg	18	4	[	[	-LRB-
cord-285091-2i2v5ecg	18	5	8	8	CD
cord-285091-2i2v5ecg	18	6	]	]	-RRB-
cord-285091-2i2v5ecg	18	7	.	.	.
cord-285091-2i2v5ecg	19	1	Structural	structural	JJ
cord-285091-2i2v5ecg	19	2	and	and	CC
cord-285091-2i2v5ecg	19	3	biochemical	biochemical	JJ
cord-285091-2i2v5ecg	19	4	studies	study	NNS
cord-285091-2i2v5ecg	19	5	revealed	reveal	VBD
cord-285091-2i2v5ecg	19	6	that	that	IN
cord-285091-2i2v5ecg	19	7	all	all	DT
cord-285091-2i2v5ecg	19	8	TLRs	tlr	NNS
cord-285091-2i2v5ecg	19	9	form	form	NN
cord-285091-2i2v5ecg	19	10	either	either	CC
cord-285091-2i2v5ecg	19	11	hetero	hetero	NNS
cord-285091-2i2v5ecg	19	12	or	or	CC
cord-285091-2i2v5ecg	19	13	homodimers	homodimer	NNS
cord-285091-2i2v5ecg	20	1	(	(	-LRB-
cord-285091-2i2v5ecg	20	2	e.g.	e.g.	RB
cord-285091-2i2v5ecg	20	3	,	,	,
cord-285091-2i2v5ecg	20	4	TLR1	TLR1	NNP
cord-285091-2i2v5ecg	20	5	/	/	SYM
cord-285091-2i2v5ecg	20	6	TLR2	TLR2	NNP
cord-285091-2i2v5ecg	20	7	,	,	,
cord-285091-2i2v5ecg	20	8	TLR2	TLR2	NNP
cord-285091-2i2v5ecg	20	9	/	/	SYM
cord-285091-2i2v5ecg	20	10	TLR6	TLR6	NNP
cord-285091-2i2v5ecg	20	11	,	,	,
cord-285091-2i2v5ecg	20	12	TLR3	TLR3	NNP
cord-285091-2i2v5ecg	20	13	/	/	SYM
cord-285091-2i2v5ecg	20	14	TLR3	TLR3	NNP
cord-285091-2i2v5ecg	20	15	,	,	,
cord-285091-2i2v5ecg	20	16	and	and	CC
cord-285091-2i2v5ecg	20	17	TLR4	TLR4	NNP
cord-285091-2i2v5ecg	20	18	/	/	SYM
cord-285091-2i2v5ecg	20	19	TLR4	TLR4	NNP
cord-285091-2i2v5ecg	20	20	)	)	-RRB-
cord-285091-2i2v5ecg	20	21	[	[	-LRB-
cord-285091-2i2v5ecg	20	22	7	7	CD
cord-285091-2i2v5ecg	20	23	,	,	,
cord-285091-2i2v5ecg	20	24	9	9	CD
cord-285091-2i2v5ecg	20	25	]	]	-RRB-
cord-285091-2i2v5ecg	20	26	.	.	.
cord-285091-2i2v5ecg	21	1	In	in	IN
cord-285091-2i2v5ecg	21	2	mammals	mammal	NNS
cord-285091-2i2v5ecg	21	3	,	,	,
cord-285091-2i2v5ecg	21	4	13	13	CD
cord-285091-2i2v5ecg	21	5	TLR	TLR	NNP
cord-285091-2i2v5ecg	21	6	family	family	NN
cord-285091-2i2v5ecg	21	7	members	member	NNS
cord-285091-2i2v5ecg	21	8	have	have	VBP
cord-285091-2i2v5ecg	21	9	been	be	VBN
cord-285091-2i2v5ecg	21	10	described	describe	VBN
cord-285091-2i2v5ecg	21	11	(	(	-LRB-
cord-285091-2i2v5ecg	21	12	13	13	CD
cord-285091-2i2v5ecg	21	13	TLR	TLR	NNP
cord-285091-2i2v5ecg	21	14	in	in	IN
cord-285091-2i2v5ecg	21	15	mice	mouse	NNS
cord-285091-2i2v5ecg	21	16	and	and	CC
cord-285091-2i2v5ecg	21	17	11	11	CD
cord-285091-2i2v5ecg	21	18	TLR	TLR	NNP
cord-285091-2i2v5ecg	21	19	in	in	IN
cord-285091-2i2v5ecg	21	20	humans	human	NNS
cord-285091-2i2v5ecg	21	21	)	)	-RRB-
cord-285091-2i2v5ecg	21	22	[	[	-LRB-
cord-285091-2i2v5ecg	21	23	10	10	CD
cord-285091-2i2v5ecg	21	24	]	]	-RRB-
cord-285091-2i2v5ecg	21	25	.	.	.
cord-285091-2i2v5ecg	22	1	While	while	IN
cord-285091-2i2v5ecg	22	2	TLR1	TLR1	NNP
cord-285091-2i2v5ecg	22	3	,	,	,
cord-285091-2i2v5ecg	22	4	2	2	CD
cord-285091-2i2v5ecg	22	5	,	,	,
cord-285091-2i2v5ecg	22	6	4	4	CD
cord-285091-2i2v5ecg	22	7	,	,	,
cord-285091-2i2v5ecg	22	8	5	5	CD
cord-285091-2i2v5ecg	22	9	and	and	CC
cord-285091-2i2v5ecg	22	10	6	6	CD
cord-285091-2i2v5ecg	22	11	are	be	VBP
cord-285091-2i2v5ecg	22	12	primarily	primarily	RB
cord-285091-2i2v5ecg	22	13	expressed	express	VBN
cord-285091-2i2v5ecg	22	14	on	on	IN
cord-285091-2i2v5ecg	22	15	the	the	DT
cord-285091-2i2v5ecg	22	16	cell	cell	NN
cord-285091-2i2v5ecg	23	1	sur-*Address	sur-*address	JJ
cord-285091-2i2v5ecg	23	2	correspondence	correspondence	NN
cord-285091-2i2v5ecg	23	3	to	to	IN
cord-285091-2i2v5ecg	23	4	this	this	DT
cord-285091-2i2v5ecg	23	5	author	author	NN
cord-285091-2i2v5ecg	23	6	at	at	IN
cord-285091-2i2v5ecg	23	7	the	the	DT
cord-285091-2i2v5ecg	23	8	Department	Department	NNP
cord-285091-2i2v5ecg	23	9	of	of	IN
cord-285091-2i2v5ecg	23	10	Biochemistry	Biochemistry	NNP
cord-285091-2i2v5ecg	23	11	,	,	,
cord-285091-2i2v5ecg	23	12	Molecular	Molecular	NNP
cord-285091-2i2v5ecg	23	13	and	and	CC
cord-285091-2i2v5ecg	23	14	Structural	Structural	NNP
cord-285091-2i2v5ecg	23	15	Biology	Biology	NNP
cord-285091-2i2v5ecg	23	16	,	,	,
cord-285091-2i2v5ecg	23	17	»	»	''
cord-285091-2i2v5ecg	23	18	Jo	Jo	NNP
cord-285091-2i2v5ecg	23	19	ef	ef	NNP
cord-285091-2i2v5ecg	23	20	Stefan	Stefan	NNP
cord-285091-2i2v5ecg	23	21	«	«	``
cord-285091-2i2v5ecg	23	22	Institute	Institute	NNP
cord-285091-2i2v5ecg	23	23	,	,	,
cord-285091-2i2v5ecg	23	24	Jamova	Jamova	NNP
cord-285091-2i2v5ecg	23	25	39	39	CD
cord-285091-2i2v5ecg	23	26	,	,	,
cord-285091-2i2v5ecg	23	27	1000	1000	CD
cord-285091-2i2v5ecg	23	28	Ljubljana	Ljubljana	NNP
cord-285091-2i2v5ecg	23	29	,	,	,
cord-285091-2i2v5ecg	23	30	Slovenia	Slovenia	NNP
cord-285091-2i2v5ecg	23	31	;	;	:
cord-285091-2i2v5ecg	23	32	Tel	Tel	NNP
cord-285091-2i2v5ecg	23	33	:	:	:
cord-285091-2i2v5ecg	23	34	+	+	SYM
cord-285091-2i2v5ecg	23	35	386	386	CD
cord-285091-2i2v5ecg	23	36	1	1	CD
cord-285091-2i2v5ecg	23	37	477	477	CD
cord-285091-2i2v5ecg	23	38	3510	3510	CD
cord-285091-2i2v5ecg	23	39	;	;	:
cord-285091-2i2v5ecg	24	1	Fax	fax	NN
cord-285091-2i2v5ecg	24	2	:	:	:
cord-285091-2i2v5ecg	24	3	+	+	SYM
cord-285091-2i2v5ecg	24	4	386	386	CD
cord-285091-2i2v5ecg	24	5	1	1	CD
cord-285091-2i2v5ecg	24	6	477	477	CD
cord-285091-2i2v5ecg	24	7	3984	3984	CD
cord-285091-2i2v5ecg	24	8	;	;	:
cord-285091-2i2v5ecg	24	9	E	e	NN
cord-285091-2i2v5ecg	24	10	-	-	NN
cord-285091-2i2v5ecg	24	11	mail	mail	NN
cord-285091-2i2v5ecg	24	12	:	:	:
cord-285091-2i2v5ecg	24	13	natasa.kopitar@ijs.si	natasa.kopitar@ijs.si	NNP
cord-285091-2i2v5ecg	24	14	face	face	NN
cord-285091-2i2v5ecg	24	15	and	and	CC
cord-285091-2i2v5ecg	24	16	recognize	recognize	VB
cord-285091-2i2v5ecg	24	17	PAMPs	pamp	NNS
cord-285091-2i2v5ecg	24	18	derived	derive	VBN
cord-285091-2i2v5ecg	24	19	from	from	IN
cord-285091-2i2v5ecg	24	20	bacteria	bacteria	NNS
cord-285091-2i2v5ecg	24	21	,	,	,
cord-285091-2i2v5ecg	24	22	fungi	fungus	NNS
cord-285091-2i2v5ecg	24	23	and	and	CC
cord-285091-2i2v5ecg	24	24	protozoa	protozoan	NNS
cord-285091-2i2v5ecg	24	25	,	,	,
cord-285091-2i2v5ecg	24	26	TLR4	TLR4	NNP
cord-285091-2i2v5ecg	24	27	recognizes	recognize	VBZ
cord-285091-2i2v5ecg	24	28	lipopolysaccharide	lipopolysaccharide	NN
cord-285091-2i2v5ecg	24	29	(	(	-LRB-
cord-285091-2i2v5ecg	24	30	LPS	LPS	NNP
cord-285091-2i2v5ecg	24	31	)	)	-RRB-
cord-285091-2i2v5ecg	24	32	,	,	,
cord-285091-2i2v5ecg	24	33	a	a	DT
cord-285091-2i2v5ecg	24	34	major	major	JJ
cord-285091-2i2v5ecg	24	35	cell	cell	NN
cord-285091-2i2v5ecg	24	36	wall	wall	NN
cord-285091-2i2v5ecg	24	37	component	component	NN
cord-285091-2i2v5ecg	24	38	of	of	IN
cord-285091-2i2v5ecg	24	39	gram	gram	JJ
cord-285091-2i2v5ecg	24	40	-	-	HYPH
cord-285091-2i2v5ecg	24	41	negative	negative	JJ
cord-285091-2i2v5ecg	24	42	bacteria	bacteria	NNS
cord-285091-2i2v5ecg	24	43	[	[	-LRB-
cord-285091-2i2v5ecg	24	44	11	11	CD
cord-285091-2i2v5ecg	24	45	]	]	-RRB-
cord-285091-2i2v5ecg	24	46	[	[	-LRB-
cord-285091-2i2v5ecg	24	47	12	12	CD
cord-285091-2i2v5ecg	24	48	]	]	-RRB-
cord-285091-2i2v5ecg	24	49	[	[	-LRB-
cord-285091-2i2v5ecg	24	50	13	13	CD
cord-285091-2i2v5ecg	24	51	]	]	-RRB-
cord-285091-2i2v5ecg	24	52	[	[	-LRB-
cord-285091-2i2v5ecg	24	53	14	14	CD
cord-285091-2i2v5ecg	24	54	]	]	-RRB-
cord-285091-2i2v5ecg	24	55	.	.	.
cord-285091-2i2v5ecg	25	1	An	an	DT
cord-285091-2i2v5ecg	25	2	essential	essential	JJ
cord-285091-2i2v5ecg	25	3	component	component	NN
cord-285091-2i2v5ecg	25	4	of	of	IN
cord-285091-2i2v5ecg	25	5	gram	gram	NN
cord-285091-2i2v5ecg	25	6	-	-	HYPH
cord-285091-2i2v5ecg	25	7	positive	positive	JJ
cord-285091-2i2v5ecg	25	8	bacteria	bacteria	NNS
cord-285091-2i2v5ecg	25	9	,	,	,
cord-285091-2i2v5ecg	25	10	peptidoglycan	peptidoglycan	NN
cord-285091-2i2v5ecg	25	11	is	be	VBZ
cord-285091-2i2v5ecg	25	12	sensed	sense	VBN
cord-285091-2i2v5ecg	25	13	by	by	IN
cord-285091-2i2v5ecg	25	14	TLR2	TLR2	NNP
cord-285091-2i2v5ecg	25	15	[	[	-LRB-
cord-285091-2i2v5ecg	25	16	15	15	CD
cord-285091-2i2v5ecg	25	17	]	]	-RRB-
cord-285091-2i2v5ecg	25	18	,	,	,
cord-285091-2i2v5ecg	25	19	which	which	WDT
cord-285091-2i2v5ecg	25	20	also	also	RB
cord-285091-2i2v5ecg	25	21	detects	detect	VBZ
cord-285091-2i2v5ecg	25	22	lipoarabinomannan	lipoarabinomannan	NNP
cord-285091-2i2v5ecg	25	23	(	(	-LRB-
cord-285091-2i2v5ecg	25	24	LAM	LAM	NNP
cord-285091-2i2v5ecg	25	25	)	)	-RRB-
cord-285091-2i2v5ecg	25	26	of	of	IN
cord-285091-2i2v5ecg	25	27	Mycobacteria	Mycobacteria	NNP
cord-285091-2i2v5ecg	25	28	[	[	-LRB-
cord-285091-2i2v5ecg	25	29	16	16	CD
cord-285091-2i2v5ecg	25	30	]	]	-RRB-
cord-285091-2i2v5ecg	25	31	.	.	.
cord-285091-2i2v5ecg	26	1	TLR2	TLR2	NNP
cord-285091-2i2v5ecg	26	2	could	could	MD
cord-285091-2i2v5ecg	26	3	form	form	VB
cord-285091-2i2v5ecg	26	4	also	also	RB
cord-285091-2i2v5ecg	26	5	heterodimers	heterodimer	NNS
cord-285091-2i2v5ecg	26	6	(	(	-LRB-
cord-285091-2i2v5ecg	26	7	in	in	IN
cord-285091-2i2v5ecg	26	8	conjugation	conjugation	NN
cord-285091-2i2v5ecg	26	9	with	with	IN
cord-285091-2i2v5ecg	26	10	TLR1	TLR1	NNP
cord-285091-2i2v5ecg	26	11	or	or	CC
cord-285091-2i2v5ecg	26	12	TLR6	TLR6	NNP
cord-285091-2i2v5ecg	26	13	)	)	-RRB-
cord-285091-2i2v5ecg	26	14	and	and	CC
cord-285091-2i2v5ecg	26	15	as	as	IN
cord-285091-2i2v5ecg	26	16	a	a	DT
cord-285091-2i2v5ecg	26	17	heterodimer	heterodimer	NN
cord-285091-2i2v5ecg	26	18	recognizes	recognize	VBZ
cord-285091-2i2v5ecg	26	19	diacyl	diacyl	NNP
cord-285091-2i2v5ecg	26	20	or	or	CC
cord-285091-2i2v5ecg	26	21	triacyl	triacyl	NNP
cord-285091-2i2v5ecg	26	22	lipopeptides	lipopeptides	NNP
cord-285091-2i2v5ecg	26	23	on	on	IN
cord-285091-2i2v5ecg	26	24	bacteria	bacteria	NNS
cord-285091-2i2v5ecg	26	25	,	,	,
cord-285091-2i2v5ecg	26	26	mycobacteria	mycobacterium	NNS
cord-285091-2i2v5ecg	26	27	and	and	CC
cord-285091-2i2v5ecg	26	28	mycoplasma	mycoplasma	NN
cord-285091-2i2v5ecg	26	29	.	.	.
cord-285091-2i2v5ecg	27	1	TLR5	TLR5	NNP
cord-285091-2i2v5ecg	27	2	senses	sense	VBZ
cord-285091-2i2v5ecg	27	3	the	the	DT
cord-285091-2i2v5ecg	27	4	flagellin	flagellin	NNP
cord-285091-2i2v5ecg	27	5	protein	protein	NN
cord-285091-2i2v5ecg	27	6	expressed	express	VBN
cord-285091-2i2v5ecg	27	7	by	by	IN
cord-285091-2i2v5ecg	27	8	flagellated	flagellated	JJ
cord-285091-2i2v5ecg	27	9	bacteria	bacteria	NNS
cord-285091-2i2v5ecg	27	10	[	[	-LRB-
cord-285091-2i2v5ecg	27	11	1	1	CD
cord-285091-2i2v5ecg	27	12	]	]	-RRB-
cord-285091-2i2v5ecg	27	13	.	.	.
cord-285091-2i2v5ecg	28	1	TLR6	TLR6	NNP
cord-285091-2i2v5ecg	28	2	participates	participate	VBZ
cord-285091-2i2v5ecg	28	3	in	in	IN
cord-285091-2i2v5ecg	28	4	the	the	DT
cord-285091-2i2v5ecg	28	5	recognition	recognition	NN
cord-285091-2i2v5ecg	28	6	of	of	IN
cord-285091-2i2v5ecg	28	7	macrophage	macrophage	NN
cord-285091-2i2v5ecg	28	8	-	-	HYPH
cord-285091-2i2v5ecg	28	9	activating	activate	VBG
cord-285091-2i2v5ecg	28	10	lipoprotein	lipoprotein	NN
cord-285091-2i2v5ecg	28	11	2	2	CD
cord-285091-2i2v5ecg	28	12	kD	kd	JJ
cord-285091-2i2v5ecg	28	13	(	(	-LRB-
cord-285091-2i2v5ecg	28	14	MALP-2	MALP-2	NNP
cord-285091-2i2v5ecg	28	15	)	)	-RRB-
cord-285091-2i2v5ecg	28	16	derived	derive	VBN
cord-285091-2i2v5ecg	28	17	from	from	IN
cord-285091-2i2v5ecg	28	18	mycoplasma	mycoplasma	NN
cord-285091-2i2v5ecg	28	19	[	[	-LRB-
cord-285091-2i2v5ecg	28	20	17	17	CD
cord-285091-2i2v5ecg	28	21	]	]	-RRB-
cord-285091-2i2v5ecg	28	22	.	.	.
cord-285091-2i2v5ecg	29	1	The	the	DT
cord-285091-2i2v5ecg	29	2	intracellular	intracellular	JJ
cord-285091-2i2v5ecg	29	3	TLR3	TLR3	NNP
cord-285091-2i2v5ecg	29	4	,	,	,
cord-285091-2i2v5ecg	29	5	TLR7	TLR7	NNP
cord-285091-2i2v5ecg	29	6	,	,	,
cord-285091-2i2v5ecg	29	7	TLR8	TLR8	NNP
cord-285091-2i2v5ecg	29	8	,	,	,
cord-285091-2i2v5ecg	29	9	and	and	CC
cord-285091-2i2v5ecg	29	10	TLR9	TLR9	NNP
cord-285091-2i2v5ecg	29	11	are	be	VBP
cord-285091-2i2v5ecg	29	12	localized	localize	VBN
cord-285091-2i2v5ecg	29	13	on	on	IN
cord-285091-2i2v5ecg	29	14	the	the	DT
cord-285091-2i2v5ecg	29	15	ER	ER	NNP
cord-285091-2i2v5ecg	29	16	membrane	membrane	NN
cord-285091-2i2v5ecg	29	17	and	and	CC
cord-285091-2i2v5ecg	29	18	only	only	RB
cord-285091-2i2v5ecg	29	19	upon	upon	IN
cord-285091-2i2v5ecg	29	20	stimulation	stimulation	NN
cord-285091-2i2v5ecg	29	21	with	with	IN
cord-285091-2i2v5ecg	29	22	PAMPs	pamp	NNS
cord-285091-2i2v5ecg	29	23	,	,	,
cord-285091-2i2v5ecg	29	24	they	-PRON-	PRP
cord-285091-2i2v5ecg	29	25	are	be	VBP
cord-285091-2i2v5ecg	29	26	targeted	target	VBN
cord-285091-2i2v5ecg	29	27	into	into	IN
cord-285091-2i2v5ecg	29	28	the	the	DT
cord-285091-2i2v5ecg	29	29	endosomes	endosome	NNS
cord-285091-2i2v5ecg	29	30	[	[	-LRB-
cord-285091-2i2v5ecg	29	31	18	18	CD
cord-285091-2i2v5ecg	29	32	]	]	-RRB-
cord-285091-2i2v5ecg	29	33	.	.	.
cord-285091-2i2v5ecg	30	1	The	the	DT
cord-285091-2i2v5ecg	30	2	intracellular	intracellular	JJ
cord-285091-2i2v5ecg	30	3	localization	localization	NN
cord-285091-2i2v5ecg	30	4	of	of	IN
cord-285091-2i2v5ecg	30	5	TLR3	TLR3	NNP
cord-285091-2i2v5ecg	30	6	,	,	,
cord-285091-2i2v5ecg	30	7	TLR7	TLR7	NNP
cord-285091-2i2v5ecg	30	8	,	,	,
cord-285091-2i2v5ecg	30	9	TLR8	TLR8	NNP
cord-285091-2i2v5ecg	30	10	,	,	,
cord-285091-2i2v5ecg	30	11	and	and	CC
cord-285091-2i2v5ecg	30	12	TLR9	TLR9	NNP
cord-285091-2i2v5ecg	30	13	is	be	VBZ
cord-285091-2i2v5ecg	30	14	regulated	regulate	VBN
cord-285091-2i2v5ecg	30	15	by	by	IN
cord-285091-2i2v5ecg	30	16	the	the	DT
cord-285091-2i2v5ecg	30	17	ER	ER	NNP
cord-285091-2i2v5ecg	30	18	membrane	membrane	NN
cord-285091-2i2v5ecg	30	19	protein	protein	NN
cord-285091-2i2v5ecg	30	20	UNC93B	unc93b	NN
cord-285091-2i2v5ecg	30	21	,	,	,
cord-285091-2i2v5ecg	30	22	which	which	WDT
cord-285091-2i2v5ecg	30	23	directly	directly	RB
cord-285091-2i2v5ecg	30	24	interacts	interact	VBZ
cord-285091-2i2v5ecg	30	25	with	with	IN
cord-285091-2i2v5ecg	30	26	the	the	DT
cord-285091-2i2v5ecg	30	27	intracellular	intracellular	JJ
cord-285091-2i2v5ecg	30	28	TLRs	tlr	NNS
cord-285091-2i2v5ecg	30	29	[	[	-LRB-
cord-285091-2i2v5ecg	30	30	19	19	CD
cord-285091-2i2v5ecg	30	31	]	]	-RRB-
cord-285091-2i2v5ecg	30	32	.	.	.
cord-285091-2i2v5ecg	31	1	TLR9	TLR9	NNP
cord-285091-2i2v5ecg	31	2	recognizes	recognize	VBZ
cord-285091-2i2v5ecg	31	3	genomic	genomic	JJ
cord-285091-2i2v5ecg	31	4	DNA	dna	NN
cord-285091-2i2v5ecg	31	5	from	from	IN
cord-285091-2i2v5ecg	31	6	DNA	dna	NN
cord-285091-2i2v5ecg	31	7	viruses	virus	NNS
cord-285091-2i2v5ecg	31	8	such	such	JJ
cord-285091-2i2v5ecg	31	9	as	as	IN
cord-285091-2i2v5ecg	31	10	HSV-1	hsv-1	NN
cord-285091-2i2v5ecg	31	11	,	,	,
cord-285091-2i2v5ecg	31	12	HSV-2	HSV-2	NNP
cord-285091-2i2v5ecg	31	13	,	,	,
cord-285091-2i2v5ecg	31	14	or	or	CC
cord-285091-2i2v5ecg	31	15	MCMV	MCMV	NNP
cord-285091-2i2v5ecg	31	16	[	[	-LRB-
cord-285091-2i2v5ecg	31	17	1	1	CD
cord-285091-2i2v5ecg	31	18	]	]	-RRB-
cord-285091-2i2v5ecg	31	19	.	.	.
cord-285091-2i2v5ecg	32	1	Viral	viral	JJ
cord-285091-2i2v5ecg	32	2	singlestranded	singlestrande	VBN
cord-285091-2i2v5ecg	32	3	RNAs	rna	NNS
cord-285091-2i2v5ecg	32	4	(	(	-LRB-
cord-285091-2i2v5ecg	32	5	ssRNAs	ssRNAs	NNP
cord-285091-2i2v5ecg	32	6	)	)	-RRB-
cord-285091-2i2v5ecg	33	1	derived	derive	VBN
cord-285091-2i2v5ecg	33	2	from	from	IN
cord-285091-2i2v5ecg	33	3	HIV	HIV	NNP
cord-285091-2i2v5ecg	33	4	or	or	CC
cord-285091-2i2v5ecg	33	5	influenza	influenza	NN
cord-285091-2i2v5ecg	33	6	virus	virus	NN
cord-285091-2i2v5ecg	33	7	are	be	VBP
cord-285091-2i2v5ecg	33	8	recognized	recognize	VBN
cord-285091-2i2v5ecg	33	9	by	by	IN
cord-285091-2i2v5ecg	33	10	TLR7	TLR7	NNP
cord-285091-2i2v5ecg	33	11	[	[	-LRB-
cord-285091-2i2v5ecg	33	12	3	3	CD
cord-285091-2i2v5ecg	33	13	]	]	-RRB-
cord-285091-2i2v5ecg	33	14	.	.	.
cord-285091-2i2v5ecg	34	1	TLR3	TLR3	NNP
cord-285091-2i2v5ecg	34	2	recognizes	recognize	VBZ
cord-285091-2i2v5ecg	34	3	dsRNA	dsrna	NN
cord-285091-2i2v5ecg	34	4	derived	derive	VBN
cord-285091-2i2v5ecg	34	5	from	from	IN
cord-285091-2i2v5ecg	34	6	Reoviruses	Reoviruses	NNP
cord-285091-2i2v5ecg	34	7	and	and	CC
cord-285091-2i2v5ecg	34	8	a	a	DT
cord-285091-2i2v5ecg	34	9	synthetic	synthetic	JJ
cord-285091-2i2v5ecg	34	10	double	double	RB
cord-285091-2i2v5ecg	34	11	-	-	HYPH
cord-285091-2i2v5ecg	34	12	stranded	strand	VBN
cord-285091-2i2v5ecg	34	13	RNA	RNA	NNP
cord-285091-2i2v5ecg	34	14	(	(	-LRB-
cord-285091-2i2v5ecg	34	15	dsRNA	dsrna	NN
cord-285091-2i2v5ecg	34	16	)	)	-RRB-
cord-285091-2i2v5ecg	34	17	analog	analog	NN
cord-285091-2i2v5ecg	34	18	,	,	,
cord-285091-2i2v5ecg	34	19	polyinosinic	polyinosinic	JJ
cord-285091-2i2v5ecg	34	20	-	-	HYPH
cord-285091-2i2v5ecg	34	21	polycytidylic	polycytidylic	NN
cord-285091-2i2v5ecg	34	22	acid	acid	NN
cord-285091-2i2v5ecg	34	23	(	(	-LRB-
cord-285091-2i2v5ecg	34	24	poly	poly	NN
cord-285091-2i2v5ecg	34	25	I	i	NN
cord-285091-2i2v5ecg	34	26	:	:	:
cord-285091-2i2v5ecg	34	27	C	C	NNP
cord-285091-2i2v5ecg	34	28	)	)	-RRB-
cord-285091-2i2v5ecg	35	1	[	[	-LRB-
cord-285091-2i2v5ecg	35	2	3	3	CD
cord-285091-2i2v5ecg	35	3	]	]	-RRB-
cord-285091-2i2v5ecg	35	4	.	.	.
cord-285091-2i2v5ecg	36	1	Signaling	signal	VBG
cord-285091-2i2v5ecg	36	2	through	through	IN
cord-285091-2i2v5ecg	36	3	TLR1	TLR1	NNP
cord-285091-2i2v5ecg	36	4	,	,	,
cord-285091-2i2v5ecg	36	5	TLR2	TLR2	NNP
cord-285091-2i2v5ecg	36	6	,	,	,
cord-285091-2i2v5ecg	36	7	TLR4	TLR4	NNP
cord-285091-2i2v5ecg	36	8	,	,	,
cord-285091-2i2v5ecg	36	9	TLR5	TLR5	NNP
cord-285091-2i2v5ecg	36	10	and	and	CC
cord-285091-2i2v5ecg	36	11	TLR6	TLR6	NNP
cord-285091-2i2v5ecg	36	12	primarily	primarily	RB
cord-285091-2i2v5ecg	36	13	induces	induce	VBZ
cord-285091-2i2v5ecg	36	14	the	the	DT
cord-285091-2i2v5ecg	36	15	production	production	NN
cord-285091-2i2v5ecg	36	16	of	of	IN
cord-285091-2i2v5ecg	36	17	inflammatory	inflammatory	JJ
cord-285091-2i2v5ecg	36	18	cytokines	cytokine	NNS
cord-285091-2i2v5ecg	36	19	,	,	,
cord-285091-2i2v5ecg	36	20	whereas	whereas	IN
cord-285091-2i2v5ecg	36	21	TLR7	TLR7	NNP
cord-285091-2i2v5ecg	36	22	and	and	CC
cord-285091-2i2v5ecg	36	23	TLR9	TLR9	NNP
cord-285091-2i2v5ecg	36	24	induce	induce	VB
cord-285091-2i2v5ecg	36	25	type	type	NN
cord-285091-2i2v5ecg	36	26	I	-PRON-	PRP
cord-285091-2i2v5ecg	36	27	interferons	interferon	NNS
cord-285091-2i2v5ecg	36	28	(	(	-LRB-
cord-285091-2i2v5ecg	36	29	IFN	IFN	NNP
cord-285091-2i2v5ecg	36	30	)	)	-RRB-
cord-285091-2i2v5ecg	37	1	[	[	-LRB-
cord-285091-2i2v5ecg	37	2	5	5	CD
cord-285091-2i2v5ecg	37	3	]	]	-RRB-
cord-285091-2i2v5ecg	37	4	.	.	.
cord-285091-2i2v5ecg	38	1	Recently	recently	RB
cord-285091-2i2v5ecg	38	2	,	,	,
cord-285091-2i2v5ecg	38	3	several	several	JJ
cord-285091-2i2v5ecg	38	4	excellent	excellent	JJ
cord-285091-2i2v5ecg	38	5	reviews	review	NNS
cord-285091-2i2v5ecg	38	6	have	have	VBP
cord-285091-2i2v5ecg	38	7	described	describe	VBN
cord-285091-2i2v5ecg	38	8	the	the	DT
cord-285091-2i2v5ecg	38	9	signaling	signaling	NN
cord-285091-2i2v5ecg	38	10	of	of	IN
cord-285091-2i2v5ecg	38	11	innate	innate	JJ
cord-285091-2i2v5ecg	38	12	immune	immune	JJ
cord-285091-2i2v5ecg	38	13	receptors	receptor	NNS
cord-285091-2i2v5ecg	38	14	,	,	,
cord-285091-2i2v5ecg	38	15	therefore	therefore	RB
cord-285091-2i2v5ecg	38	16	those	those	DT
cord-285091-2i2v5ecg	38	17	aspect	aspect	NN
cord-285091-2i2v5ecg	38	18	will	will	MD
cord-285091-2i2v5ecg	38	19	not	not	RB
cord-285091-2i2v5ecg	38	20	be	be	VB
cord-285091-2i2v5ecg	38	21	discussed	discuss	VBN
cord-285091-2i2v5ecg	38	22	in	in	IN
cord-285091-2i2v5ecg	38	23	detail	detail	NN
cord-285091-2i2v5ecg	38	24	[	[	-LRB-
cord-285091-2i2v5ecg	38	25	4	4	CD
cord-285091-2i2v5ecg	38	26	]	]	-RRB-
cord-285091-2i2v5ecg	38	27	[	[	-LRB-
cord-285091-2i2v5ecg	38	28	5	5	CD
cord-285091-2i2v5ecg	38	29	]	]	-RRB-
cord-285091-2i2v5ecg	38	30	[	[	-LRB-
cord-285091-2i2v5ecg	38	31	6	6	CD
cord-285091-2i2v5ecg	38	32	]	]	-RRB-
cord-285091-2i2v5ecg	38	33	20	20	CD
cord-285091-2i2v5ecg	38	34	]	]	-RRB-
cord-285091-2i2v5ecg	38	35	.	.	.
cord-285091-2i2v5ecg	39	1	Proteases	protease	NNS
cord-285091-2i2v5ecg	39	2	play	play	VBP
cord-285091-2i2v5ecg	39	3	significant	significant	JJ
cord-285091-2i2v5ecg	39	4	roles	role	NNS
cord-285091-2i2v5ecg	39	5	in	in	IN
cord-285091-2i2v5ecg	39	6	innate	innate	NN
cord-285091-2i2v5ecg	39	7	as	as	RB
cord-285091-2i2v5ecg	39	8	well	well	RB
cord-285091-2i2v5ecg	39	9	as	as	IN
cord-285091-2i2v5ecg	39	10	adaptive	adaptive	JJ
cord-285091-2i2v5ecg	39	11	immune	immune	JJ
cord-285091-2i2v5ecg	39	12	response	response	NN
cord-285091-2i2v5ecg	39	13	.	.	.
cord-285091-2i2v5ecg	40	1	They	-PRON-	PRP
cord-285091-2i2v5ecg	40	2	are	be	VBP
cord-285091-2i2v5ecg	40	3	classified	classify	VBN
cord-285091-2i2v5ecg	40	4	by	by	IN
cord-285091-2i2v5ecg	40	5	their	-PRON-	PRP$
cord-285091-2i2v5ecg	40	6	gene	gene	NN
cord-285091-2i2v5ecg	40	7	sequence	sequence	NN
cord-285091-2i2v5ecg	40	8	homology	homology	NN
cord-285091-2i2v5ecg	40	9	and	and	CC
cord-285091-2i2v5ecg	40	10	according	accord	VBG
cord-285091-2i2v5ecg	40	11	to	to	IN
cord-285091-2i2v5ecg	40	12	their	-PRON-	PRP$
cord-285091-2i2v5ecg	40	13	catalytic	catalytic	JJ
cord-285091-2i2v5ecg	40	14	mechanism	mechanism	NN
cord-285091-2i2v5ecg	40	15	as	as	IN
cord-285091-2i2v5ecg	40	16	cysteine	cysteine	NN
cord-285091-2i2v5ecg	40	17	,	,	,
cord-285091-2i2v5ecg	40	18	serine	serine	NN
cord-285091-2i2v5ecg	40	19	,	,	,
cord-285091-2i2v5ecg	40	20	threonine	threonine	NN
cord-285091-2i2v5ecg	40	21	,	,	,
cord-285091-2i2v5ecg	40	22	aspartate	aspartate	NN
cord-285091-2i2v5ecg	40	23	and	and	CC
cord-285091-2i2v5ecg	40	24	metalloproteases	metalloprotease	NNS
cord-285091-2i2v5ecg	40	25	,	,	,
cord-285091-2i2v5ecg	40	26	or	or	CC
cord-285091-2i2v5ecg	40	27	unknown	unknown	JJ
cord-285091-2i2v5ecg	40	28	proteases	protease	NNS
cord-285091-2i2v5ecg	40	29	[	[	-LRB-
cord-285091-2i2v5ecg	40	30	21	21	CD
cord-285091-2i2v5ecg	40	31	]	]	-RRB-
cord-285091-2i2v5ecg	40	32	(	(	-LRB-
cord-285091-2i2v5ecg	41	1	http://www.merops	http://www.merop	NNS
cord-285091-2i2v5ecg	41	2	.	.	.
cord-285091-2i2v5ecg	41	3	sanger.ac.uk	sanger.ac.uk	RB
cord-285091-2i2v5ecg	41	4	)	)	-RRB-
cord-285091-2i2v5ecg	41	5	.	.	.
cord-285091-2i2v5ecg	42	1	The	the	DT
cord-285091-2i2v5ecg	42	2	activity	activity	NN
cord-285091-2i2v5ecg	42	3	of	of	IN
cord-285091-2i2v5ecg	42	4	different	different	JJ
cord-285091-2i2v5ecg	42	5	proteases	protease	NNS
cord-285091-2i2v5ecg	42	6	is	be	VBZ
cord-285091-2i2v5ecg	42	7	tightly	tightly	RB
cord-285091-2i2v5ecg	42	8	controlled	control	VBN
cord-285091-2i2v5ecg	42	9	at	at	IN
cord-285091-2i2v5ecg	42	10	the	the	DT
cord-285091-2i2v5ecg	42	11	level	level	NN
cord-285091-2i2v5ecg	42	12	of	of	IN
cord-285091-2i2v5ecg	42	13	expression	expression	NN
cord-285091-2i2v5ecg	42	14	,	,	,
cord-285091-2i2v5ecg	42	15	zymogene	zymogene	NNP
cord-285091-2i2v5ecg	42	16	activation	activation	NN
cord-285091-2i2v5ecg	42	17	,	,	,
cord-285091-2i2v5ecg	42	18	localization	localization	NN
cord-285091-2i2v5ecg	42	19	in	in	IN
cord-285091-2i2v5ecg	42	20	different	different	JJ
cord-285091-2i2v5ecg	42	21	cellular	cellular	JJ
cord-285091-2i2v5ecg	42	22	compartments	compartment	NNS
cord-285091-2i2v5ecg	42	23	,	,	,
cord-285091-2i2v5ecg	42	24	or	or	CC
cord-285091-2i2v5ecg	42	25	by	by	IN
cord-285091-2i2v5ecg	42	26	protease	protease	NN
cord-285091-2i2v5ecg	42	27	inhibitors	inhibitor	NNS
cord-285091-2i2v5ecg	42	28	.	.	.
cord-285091-2i2v5ecg	43	1	Many	many	JJ
cord-285091-2i2v5ecg	43	2	pathogenic	pathogenic	JJ
cord-285091-2i2v5ecg	43	3	organisms	organism	NNS
cord-285091-2i2v5ecg	43	4	synthesize	synthesize	VBP
cord-285091-2i2v5ecg	43	5	proteases	protease	NNS
cord-285091-2i2v5ecg	43	6	that	that	WDT
cord-285091-2i2v5ecg	43	7	resemble	resemble	VBP
cord-285091-2i2v5ecg	43	8	host	host	NN
cord-285091-2i2v5ecg	43	9	proteases	protease	NNS
cord-285091-2i2v5ecg	43	10	.	.	.
cord-285091-2i2v5ecg	44	1	Indeed	indeed	RB
cord-285091-2i2v5ecg	44	2	,	,	,
cord-285091-2i2v5ecg	44	3	amino	amino	NN
cord-285091-2i2v5ecg	44	4	-	-	HYPH
cord-285091-2i2v5ecg	44	5	acid	acid	NN
cord-285091-2i2v5ecg	44	6	sequences	sequence	NNS
cord-285091-2i2v5ecg	44	7	typical	typical	JJ
cord-285091-2i2v5ecg	44	8	of	of	IN
cord-285091-2i2v5ecg	44	9	pathogen	pathogen	NN
cord-285091-2i2v5ecg	44	10	proteases	protease	NNS
cord-285091-2i2v5ecg	44	11	exist	exist	VBP
cord-285091-2i2v5ecg	44	12	in	in	IN
cord-285091-2i2v5ecg	44	13	key	key	JJ
cord-285091-2i2v5ecg	44	14	molecules	molecule	NNS
cord-285091-2i2v5ecg	44	15	involved	involve	VBN
cord-285091-2i2v5ecg	44	16	in	in	IN
cord-285091-2i2v5ecg	44	17	host	host	NN
cord-285091-2i2v5ecg	44	18	immune	immune	JJ
cord-285091-2i2v5ecg	44	19	response	response	NN
cord-285091-2i2v5ecg	44	20	regulation	regulation	NN
cord-285091-2i2v5ecg	44	21	including	include	VBG
cord-285091-2i2v5ecg	44	22	immunoglobulins	immunoglobulin	NNS
cord-285091-2i2v5ecg	44	23	(	(	-LRB-
cord-285091-2i2v5ecg	44	24	Ig	Ig	NNP
cord-285091-2i2v5ecg	44	25	)	)	-RRB-
cord-285091-2i2v5ecg	44	26	,	,	,
cord-285091-2i2v5ecg	44	27	cytokines	cytokine	NNS
cord-285091-2i2v5ecg	44	28	and	and	CC
cord-285091-2i2v5ecg	44	29	chemokines	chemokine	NNS
cord-285091-2i2v5ecg	44	30	.	.	.
cord-285091-2i2v5ecg	45	1	Here	here	RB
cord-285091-2i2v5ecg	45	2	,	,	,
cord-285091-2i2v5ecg	45	3	I	-PRON-	PRP
cord-285091-2i2v5ecg	45	4	will	will	MD
cord-285091-2i2v5ecg	45	5	discuss	discuss	VB
cord-285091-2i2v5ecg	45	6	the	the	DT
cord-285091-2i2v5ecg	45	7	functional	functional	JJ
cord-285091-2i2v5ecg	45	8	role	role	NN
cord-285091-2i2v5ecg	45	9	of	of	IN
cord-285091-2i2v5ecg	45	10	proteinase	proteinase	NN
cord-285091-2i2v5ecg	45	11	and	and	CC
cord-285091-2i2v5ecg	45	12	inhibitors	inhibitor	NNS
cord-285091-2i2v5ecg	45	13	from	from	IN
cord-285091-2i2v5ecg	45	14	metazoan	metazoan	NN
cord-285091-2i2v5ecg	45	15	hosts	host	NNS
cord-285091-2i2v5ecg	45	16	and	and	CC
cord-285091-2i2v5ecg	45	17	microbial	microbial	JJ
cord-285091-2i2v5ecg	45	18	pathogens	pathogen	NNS
cord-285091-2i2v5ecg	45	19	,	,	,
cord-285091-2i2v5ecg	45	20	at	at	IN
cord-285091-2i2v5ecg	45	21	the	the	DT
cord-285091-2i2v5ecg	45	22	cross	cross	NN
cord-285091-2i2v5ecg	45	23	talk	talk	NN
cord-285091-2i2v5ecg	45	24	of	of	IN
cord-285091-2i2v5ecg	45	25	host	host	NN
cord-285091-2i2v5ecg	45	26	pathogen	pathogen	NN
cord-285091-2i2v5ecg	45	27	interactions	interaction	NNS
cord-285091-2i2v5ecg	45	28	and	and	CC
cord-285091-2i2v5ecg	45	29	the	the	DT
cord-285091-2i2v5ecg	45	30	contribution	contribution	NN
cord-285091-2i2v5ecg	45	31	of	of	IN
cord-285091-2i2v5ecg	45	32	these	these	DT
cord-285091-2i2v5ecg	45	33	interactions	interaction	NNS
cord-285091-2i2v5ecg	45	34	to	to	TO
cord-285091-2i2v5ecg	45	35	host	host	VB
cord-285091-2i2v5ecg	45	36	protection	protection	NN
cord-285091-2i2v5ecg	45	37	and	and	CC
cord-285091-2i2v5ecg	45	38	susceptibility	susceptibility	NN
cord-285091-2i2v5ecg	45	39	to	to	IN
cord-285091-2i2v5ecg	45	40	infections	infection	NNS
cord-285091-2i2v5ecg	45	41	.	.	.
cord-285091-2i2v5ecg	46	1	Cysteine	cysteine	NN
cord-285091-2i2v5ecg	46	2	cathepsins	cathepsin	NNS
cord-285091-2i2v5ecg	46	3	were	be	VBD
cord-285091-2i2v5ecg	46	4	long	long	RB
cord-285091-2i2v5ecg	46	5	known	know	VBN
cord-285091-2i2v5ecg	46	6	to	to	TO
cord-285091-2i2v5ecg	46	7	be	be	VB
cord-285091-2i2v5ecg	46	8	involved	involve	VBN
cord-285091-2i2v5ecg	46	9	in	in	IN
cord-285091-2i2v5ecg	46	10	protein	protein	NN
cord-285091-2i2v5ecg	46	11	degradation	degradation	NN
cord-285091-2i2v5ecg	46	12	in	in	IN
cord-285091-2i2v5ecg	46	13	lysosomes	lysosome	NNS
cord-285091-2i2v5ecg	46	14	[	[	-LRB-
cord-285091-2i2v5ecg	46	15	22	22	CD
cord-285091-2i2v5ecg	46	16	]	]	-RRB-
cord-285091-2i2v5ecg	46	17	.	.	.
cord-285091-2i2v5ecg	47	1	They	-PRON-	PRP
cord-285091-2i2v5ecg	47	2	are	be	VBP
cord-285091-2i2v5ecg	47	3	papain	papain	NN
cord-285091-2i2v5ecg	47	4	-	-	HYPH
cord-285091-2i2v5ecg	47	5	like	like	JJ
cord-285091-2i2v5ecg	47	6	cysteine	cysteine	NN
cord-285091-2i2v5ecg	47	7	proteinases	proteinase	NNS
cord-285091-2i2v5ecg	47	8	belonging	belong	VBG
cord-285091-2i2v5ecg	47	9	to	to	TO
cord-285091-2i2v5ecg	47	10	clan	clan	NNP
cord-285091-2i2v5ecg	47	11	CA	CA	NNP
cord-285091-2i2v5ecg	47	12	,	,	,
cord-285091-2i2v5ecg	47	13	family	family	NN
cord-285091-2i2v5ecg	47	14	C1	C1	NNP
cord-285091-2i2v5ecg	47	15	[	[	-LRB-
cord-285091-2i2v5ecg	47	16	23	23	CD
cord-285091-2i2v5ecg	47	17	]	]	-RRB-
cord-285091-2i2v5ecg	47	18	.	.	.
cord-285091-2i2v5ecg	48	1	Eleven	eleven	CD
cord-285091-2i2v5ecg	48	2	human	human	JJ
cord-285091-2i2v5ecg	48	3	cathepsins	cathepsin	NNS
cord-285091-2i2v5ecg	48	4	are	be	VBP
cord-285091-2i2v5ecg	48	5	known	know	VBN
cord-285091-2i2v5ecg	48	6	(	(	-LRB-
cord-285091-2i2v5ecg	48	7	B	b	NN
cord-285091-2i2v5ecg	48	8	,	,	,
cord-285091-2i2v5ecg	48	9	H	H	NNP
cord-285091-2i2v5ecg	48	10	,	,	,
cord-285091-2i2v5ecg	48	11	L	L	NNP
cord-285091-2i2v5ecg	48	12	,	,	,
cord-285091-2i2v5ecg	48	13	S	S	NNP
cord-285091-2i2v5ecg	48	14	,	,	,
cord-285091-2i2v5ecg	48	15	C	C	NNP
cord-285091-2i2v5ecg	48	16	,	,	,
cord-285091-2i2v5ecg	48	17	K	K	NNP
cord-285091-2i2v5ecg	48	18	,	,	,
cord-285091-2i2v5ecg	48	19	O	o	UH
cord-285091-2i2v5ecg	48	20	,	,	,
cord-285091-2i2v5ecg	48	21	F	F	NNP
cord-285091-2i2v5ecg	48	22	,	,	,
cord-285091-2i2v5ecg	48	23	V	V	NNP
cord-285091-2i2v5ecg	48	24	,	,	,
cord-285091-2i2v5ecg	48	25	X	X	NNP
cord-285091-2i2v5ecg	48	26	and	and	CC
cord-285091-2i2v5ecg	48	27	W	W	NNP
cord-285091-2i2v5ecg	48	28	)	)	-RRB-
cord-285091-2i2v5ecg	48	29	.	.	.
cord-285091-2i2v5ecg	49	1	With	with	IN
cord-285091-2i2v5ecg	49	2	the	the	DT
cord-285091-2i2v5ecg	49	3	exception	exception	NN
cord-285091-2i2v5ecg	49	4	of	of	IN
cord-285091-2i2v5ecg	49	5	cathepsins	cathepsin	NNS
cord-285091-2i2v5ecg	49	6	S	S	NNP
cord-285091-2i2v5ecg	49	7	,	,	,
cord-285091-2i2v5ecg	49	8	V	v	NN
cord-285091-2i2v5ecg	49	9	,	,	,
cord-285091-2i2v5ecg	49	10	K	K	NNP
cord-285091-2i2v5ecg	49	11	and	and	CC
cord-285091-2i2v5ecg	49	12	W	W	NNP
cord-285091-2i2v5ecg	49	13	,	,	,
cord-285091-2i2v5ecg	49	14	they	-PRON-	PRP
cord-285091-2i2v5ecg	49	15	are	be	VBP
cord-285091-2i2v5ecg	49	16	widely	widely	RB
cord-285091-2i2v5ecg	49	17	expressed	express	VBN
cord-285091-2i2v5ecg	49	18	in	in	IN
cord-285091-2i2v5ecg	49	19	a	a	DT
cord-285091-2i2v5ecg	49	20	number	number	NN
cord-285091-2i2v5ecg	49	21	of	of	IN
cord-285091-2i2v5ecg	49	22	different	different	JJ
cord-285091-2i2v5ecg	49	23	cells	cell	NNS
cord-285091-2i2v5ecg	49	24	and	and	CC
cord-285091-2i2v5ecg	49	25	tissues	tissue	NNS
cord-285091-2i2v5ecg	49	26	.	.	.
cord-285091-2i2v5ecg	50	1	Despite	despite	IN
cord-285091-2i2v5ecg	50	2	similarities	similarity	NNS
cord-285091-2i2v5ecg	50	3	in	in	IN
cord-285091-2i2v5ecg	50	4	sequence	sequence	NN
cord-285091-2i2v5ecg	50	5	and	and	CC
cord-285091-2i2v5ecg	50	6	structure	structure	NN
cord-285091-2i2v5ecg	50	7	,	,	,
cord-285091-2i2v5ecg	50	8	cysteine	cysteine	NN
cord-285091-2i2v5ecg	50	9	cathepsins	cathepsin	NNS
cord-285091-2i2v5ecg	50	10	differ	differ	VBP
cord-285091-2i2v5ecg	50	11	among	among	IN
cord-285091-2i2v5ecg	50	12	each	each	DT
cord-285091-2i2v5ecg	50	13	other	other	JJ
cord-285091-2i2v5ecg	50	14	in	in	IN
cord-285091-2i2v5ecg	50	15	specificity	specificity	NN
cord-285091-2i2v5ecg	50	16	.	.	.
cord-285091-2i2v5ecg	51	1	Most	Most	JJS
cord-285091-2i2v5ecg	51	2	of	of	IN
cord-285091-2i2v5ecg	51	3	the	the	DT
cord-285091-2i2v5ecg	51	4	cathepsins	cathepsin	NNS
cord-285091-2i2v5ecg	51	5	are	be	VBP
cord-285091-2i2v5ecg	51	6	endopeptidases	endopeptidase	NNS
cord-285091-2i2v5ecg	51	7	,	,	,
cord-285091-2i2v5ecg	51	8	although	although	IN
cord-285091-2i2v5ecg	51	9	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	51	10	B	b	NN
cord-285091-2i2v5ecg	51	11	and	and	CC
cord-285091-2i2v5ecg	51	12	X	X	NNS
cord-285091-2i2v5ecg	51	13	are	be	VBP
cord-285091-2i2v5ecg	51	14	also	also	RB
cord-285091-2i2v5ecg	51	15	carboxydipeptidases	carboxydipeptidase	NNS
cord-285091-2i2v5ecg	51	16	,	,	,
cord-285091-2i2v5ecg	51	17	and	and	CC
cord-285091-2i2v5ecg	52	1	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	52	2	H	H	NNP
cord-285091-2i2v5ecg	52	3	and	and	CC
cord-285091-2i2v5ecg	52	4	C	C	NNP
cord-285091-2i2v5ecg	52	5	are	be	VBP
cord-285091-2i2v5ecg	52	6	aminopeptidases	aminopeptidases	NNPS
cord-285091-2i2v5ecg	52	7	[	[	-LRB-
cord-285091-2i2v5ecg	52	8	24	24	CD
cord-285091-2i2v5ecg	52	9	,	,	,
cord-285091-2i2v5ecg	52	10	25	25	CD
cord-285091-2i2v5ecg	52	11	]	]	-RRB-
cord-285091-2i2v5ecg	52	12	.	.	.
cord-285091-2i2v5ecg	53	1	Cysteine	cysteine	NN
cord-285091-2i2v5ecg	53	2	cathepsins	cathepsin	NNS
cord-285091-2i2v5ecg	53	3	exhibit	exhibit	VBP
cord-285091-2i2v5ecg	53	4	a	a	DT
cord-285091-2i2v5ecg	53	5	broad	broad	JJ
cord-285091-2i2v5ecg	53	6	variety	variety	NN
cord-285091-2i2v5ecg	53	7	of	of	IN
cord-285091-2i2v5ecg	53	8	functions	function	NNS
cord-285091-2i2v5ecg	53	9	[	[	-LRB-
cord-285091-2i2v5ecg	53	10	26	26	CD
cord-285091-2i2v5ecg	53	11	]	]	-RRB-
cord-285091-2i2v5ecg	53	12	[	[	-LRB-
cord-285091-2i2v5ecg	53	13	27	27	CD
cord-285091-2i2v5ecg	53	14	]	]	-RRB-
cord-285091-2i2v5ecg	53	15	[	[	-LRB-
cord-285091-2i2v5ecg	53	16	28	28	CD
cord-285091-2i2v5ecg	53	17	]	]	-RRB-
cord-285091-2i2v5ecg	53	18	.	.	.
cord-285091-2i2v5ecg	54	1	The	the	DT
cord-285091-2i2v5ecg	54	2	human	human	JJ
cord-285091-2i2v5ecg	54	3	genome	genome	NN
cord-285091-2i2v5ecg	54	4	encodes	encode	VBZ
cord-285091-2i2v5ecg	54	5	for	for	IN
cord-285091-2i2v5ecg	54	6	two	two	CD
cord-285091-2i2v5ecg	54	7	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	54	8	L	l	NN
cord-285091-2i2v5ecg	54	9	-	-	HYPH
cord-285091-2i2v5ecg	54	10	like	like	JJ
cord-285091-2i2v5ecg	54	11	proteases	protease	NNS
cord-285091-2i2v5ecg	54	12	,	,	,
cord-285091-2i2v5ecg	54	13	namely	namely	RB
cord-285091-2i2v5ecg	54	14	the	the	DT
cord-285091-2i2v5ecg	54	15	human	human	JJ
cord-285091-2i2v5ecg	54	16	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	54	17	L	l	NN
cord-285091-2i2v5ecg	54	18	and	and	CC
cord-285091-2i2v5ecg	54	19	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	54	20	V	v	NN
cord-285091-2i2v5ecg	54	21	(	(	-LRB-
cord-285091-2i2v5ecg	54	22	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	54	23	L2	L2	NNP
cord-285091-2i2v5ecg	54	24	)	)	-RRB-
cord-285091-2i2v5ecg	54	25	,	,	,
cord-285091-2i2v5ecg	54	26	whereas	whereas	IN
cord-285091-2i2v5ecg	54	27	in	in	IN
cord-285091-2i2v5ecg	54	28	mouse	mouse	NN
cord-285091-2i2v5ecg	54	29	only	only	RB
cord-285091-2i2v5ecg	54	30	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	54	31	L	l	NN
cord-285091-2i2v5ecg	54	32	is	be	VBZ
cord-285091-2i2v5ecg	54	33	present	present	JJ
cord-285091-2i2v5ecg	54	34	[	[	-LRB-
cord-285091-2i2v5ecg	54	35	29	29	CD
cord-285091-2i2v5ecg	54	36	]	]	-RRB-
cord-285091-2i2v5ecg	54	37	.	.	.
cord-285091-2i2v5ecg	55	1	Cathepsin	Cathepsin	NNP
cord-285091-2i2v5ecg	55	2	V	v	NN
cord-285091-2i2v5ecg	55	3	expression	expression	NN
cord-285091-2i2v5ecg	55	4	is	be	VBZ
cord-285091-2i2v5ecg	55	5	restricted	restrict	VBN
cord-285091-2i2v5ecg	55	6	to	to	IN
cord-285091-2i2v5ecg	55	7	thymus	thymus	NN
cord-285091-2i2v5ecg	55	8	,	,	,
cord-285091-2i2v5ecg	55	9	testis	testis	NN
cord-285091-2i2v5ecg	55	10	and	and	CC
cord-285091-2i2v5ecg	55	11	corneal	corneal	JJ
cord-285091-2i2v5ecg	55	12	epithelium	epithelium	NN
cord-285091-2i2v5ecg	55	13	,	,	,
cord-285091-2i2v5ecg	55	14	while	while	IN
cord-285091-2i2v5ecg	55	15	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	55	16	L	l	NN
cord-285091-2i2v5ecg	55	17	is	be	VBZ
cord-285091-2i2v5ecg	55	18	ubiquitously	ubiquitously	RB
cord-285091-2i2v5ecg	55	19	expressed	express	VBN
cord-285091-2i2v5ecg	55	20	[	[	-LRB-
cord-285091-2i2v5ecg	55	21	30	30	CD
cord-285091-2i2v5ecg	55	22	,	,	,
cord-285091-2i2v5ecg	55	23	31	31	CD
cord-285091-2i2v5ecg	55	24	]	]	-RRB-
cord-285091-2i2v5ecg	55	25	.	.	.
cord-285091-2i2v5ecg	56	1	Cathepsins	cathepsin	NNS
cord-285091-2i2v5ecg	56	2	are	be	VBP
cord-285091-2i2v5ecg	56	3	synthesised	synthesise	VBN
cord-285091-2i2v5ecg	56	4	as	as	IN
cord-285091-2i2v5ecg	56	5	preproproteins	preproprotein	NNS
cord-285091-2i2v5ecg	56	6	,	,	,
cord-285091-2i2v5ecg	56	7	which	which	WDT
cord-285091-2i2v5ecg	56	8	are	be	VBP
cord-285091-2i2v5ecg	56	9	activated	activate	VBN
cord-285091-2i2v5ecg	56	10	either	either	CC
cord-285091-2i2v5ecg	56	11	by	by	IN
cord-285091-2i2v5ecg	56	12	other	other	JJ
cord-285091-2i2v5ecg	56	13	proteinases	proteinase	NNS
cord-285091-2i2v5ecg	56	14	or	or	CC
cord-285091-2i2v5ecg	56	15	self	self	NN
cord-285091-2i2v5ecg	56	16	-	-	HYPH
cord-285091-2i2v5ecg	56	17	activated	activate	VBN
cord-285091-2i2v5ecg	57	1	(	(	-LRB-
cord-285091-2i2v5ecg	57	2	in	in	IN
cord-285091-2i2v5ecg	57	3	the	the	DT
cord-285091-2i2v5ecg	57	4	case	case	NN
cord-285091-2i2v5ecg	57	5	of	of	IN
cord-285091-2i2v5ecg	57	6	endopeptidases	endopeptidase	NNS
cord-285091-2i2v5ecg	57	7	)	)	-RRB-
cord-285091-2i2v5ecg	57	8	.	.	.
cord-285091-2i2v5ecg	58	1	Cathepsins	cathepsin	NNS
cord-285091-2i2v5ecg	58	2	are	be	VBP
cord-285091-2i2v5ecg	58	3	optimally	optimally	RB
cord-285091-2i2v5ecg	58	4	active	active	JJ
cord-285091-2i2v5ecg	58	5	in	in	IN
cord-285091-2i2v5ecg	58	6	the	the	DT
cord-285091-2i2v5ecg	58	7	acidic	acidic	JJ
cord-285091-2i2v5ecg	58	8	environment	environment	NN
cord-285091-2i2v5ecg	58	9	in	in	IN
cord-285091-2i2v5ecg	58	10	endolysosomes	endolysosome	NNS
cord-285091-2i2v5ecg	58	11	.	.	.
cord-285091-2i2v5ecg	59	1	However	however	RB
cord-285091-2i2v5ecg	59	2	,	,	,
cord-285091-2i2v5ecg	59	3	they	-PRON-	PRP
cord-285091-2i2v5ecg	59	4	are	be	VBP
cord-285091-2i2v5ecg	59	5	still	still	RB
cord-285091-2i2v5ecg	59	6	active	active	JJ
cord-285091-2i2v5ecg	59	7	in	in	IN
cord-285091-2i2v5ecg	59	8	the	the	DT
cord-285091-2i2v5ecg	59	9	extracellular	extracellular	JJ
cord-285091-2i2v5ecg	59	10	space	space	NN
cord-285091-2i2v5ecg	59	11	and	and	CC
cord-285091-2i2v5ecg	59	12	in	in	IN
cord-285091-2i2v5ecg	59	13	the	the	DT
cord-285091-2i2v5ecg	59	14	nucleus	nucleus	NN
cord-285091-2i2v5ecg	59	15	despite	despite	IN
cord-285091-2i2v5ecg	59	16	a	a	DT
cord-285091-2i2v5ecg	59	17	neutral	neutral	JJ
cord-285091-2i2v5ecg	59	18	pH	pH	NNP
cord-285091-2i2v5ecg	59	19	[	[	-LRB-
cord-285091-2i2v5ecg	59	20	32	32	CD
cord-285091-2i2v5ecg	59	21	]	]	-RRB-
cord-285091-2i2v5ecg	59	22	.	.	.
cord-285091-2i2v5ecg	60	1	Seminal	seminal	JJ
cord-285091-2i2v5ecg	60	2	study	study	NN
cord-285091-2i2v5ecg	60	3	by	by	IN
cord-285091-2i2v5ecg	60	4	Goulet	Goulet	NNP
cord-285091-2i2v5ecg	60	5	et	et	NNP
cord-285091-2i2v5ecg	60	6	al	al	NNP
cord-285091-2i2v5ecg	60	7	.	.	NNP
cord-285091-2i2v5ecg	60	8	showed	show	VBD
cord-285091-2i2v5ecg	60	9	that	that	IN
cord-285091-2i2v5ecg	60	10	nuclear	nuclear	JJ
cord-285091-2i2v5ecg	60	11	procathepsin	procathepsin	NNP
cord-285091-2i2v5ecg	60	12	L	L	NNP
cord-285091-2i2v5ecg	60	13	processed	process	VBD
cord-285091-2i2v5ecg	60	14	the	the	DT
cord-285091-2i2v5ecg	60	15	transcriptional	transcriptional	JJ
cord-285091-2i2v5ecg	60	16	factor	factor	NN
cord-285091-2i2v5ecg	60	17	CUX1	CUX1	NNP
cord-285091-2i2v5ecg	60	18	into	into	IN
cord-285091-2i2v5ecg	60	19	a	a	DT
cord-285091-2i2v5ecg	60	20	form	form	NN
cord-285091-2i2v5ecg	60	21	with	with	IN
cord-285091-2i2v5ecg	60	22	enhanced	enhance	VBN
cord-285091-2i2v5ecg	60	23	DNA	dna	NN
cord-285091-2i2v5ecg	60	24	binding	binding	NN
cord-285091-2i2v5ecg	60	25	and	and	CC
cord-285091-2i2v5ecg	60	26	that	that	DT
cord-285091-2i2v5ecg	60	27	promotes	promote	VBZ
cord-285091-2i2v5ecg	60	28	cell	cell	NN
cord-285091-2i2v5ecg	60	29	cycle	cycle	NN
cord-285091-2i2v5ecg	60	30	progression	progression	NN
cord-285091-2i2v5ecg	60	31	[	[	-LRB-
cord-285091-2i2v5ecg	60	32	32	32	CD
cord-285091-2i2v5ecg	60	33	]	]	-RRB-
cord-285091-2i2v5ecg	60	34	.	.	.
cord-285091-2i2v5ecg	61	1	Cathepsin	Cathepsin	NNP
cord-285091-2i2v5ecg	61	2	L	L	NNP
cord-285091-2i2v5ecg	61	3	was	be	VBD
cord-285091-2i2v5ecg	61	4	targeted	target	VBN
cord-285091-2i2v5ecg	61	5	into	into	IN
cord-285091-2i2v5ecg	61	6	the	the	DT
cord-285091-2i2v5ecg	61	7	nucleus	nucleus	NN
cord-285091-2i2v5ecg	61	8	through	through	IN
cord-285091-2i2v5ecg	61	9	translation	translation	NN
cord-285091-2i2v5ecg	61	10	initiation	initiation	NN
cord-285091-2i2v5ecg	61	11	at	at	IN
cord-285091-2i2v5ecg	61	12	alternative	alternative	JJ
cord-285091-2i2v5ecg	61	13	start	start	NN
cord-285091-2i2v5ecg	61	14	codons	codon	NNS
cord-285091-2i2v5ecg	61	15	downstream	downstream	RB
cord-285091-2i2v5ecg	61	16	of	of	IN
cord-285091-2i2v5ecg	61	17	the	the	DT
cord-285091-2i2v5ecg	61	18	normal	normal	JJ
cord-285091-2i2v5ecg	61	19	signal	signal	NN
cord-285091-2i2v5ecg	61	20	sequence	sequence	NN
cord-285091-2i2v5ecg	61	21	[	[	-LRB-
cord-285091-2i2v5ecg	61	22	32	32	CD
cord-285091-2i2v5ecg	61	23	]	]	-RRB-
cord-285091-2i2v5ecg	61	24	.	.	.
cord-285091-2i2v5ecg	62	1	Recently	recently	RB
cord-285091-2i2v5ecg	62	2	,	,	,
cord-285091-2i2v5ecg	62	3	also	also	RB
cord-285091-2i2v5ecg	62	4	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	62	5	B	b	NN
cord-285091-2i2v5ecg	62	6	and	and	CC
cord-285091-2i2v5ecg	62	7	F	F	NNP
cord-285091-2i2v5ecg	62	8	were	be	VBD
cord-285091-2i2v5ecg	62	9	reported	report	VBN
cord-285091-2i2v5ecg	62	10	to	to	TO
cord-285091-2i2v5ecg	62	11	be	be	VB
cord-285091-2i2v5ecg	62	12	localized	localize	VBN
cord-285091-2i2v5ecg	62	13	in	in	IN
cord-285091-2i2v5ecg	62	14	the	the	DT
cord-285091-2i2v5ecg	62	15	nucleus	nucleus	NN
cord-285091-2i2v5ecg	62	16	[	[	-LRB-
cord-285091-2i2v5ecg	62	17	33	33	CD
cord-285091-2i2v5ecg	62	18	]	]	-RRB-
cord-285091-2i2v5ecg	62	19	[	[	-LRB-
cord-285091-2i2v5ecg	62	20	34	34	CD
cord-285091-2i2v5ecg	62	21	]	]	-RRB-
cord-285091-2i2v5ecg	62	22	[	[	-LRB-
cord-285091-2i2v5ecg	62	23	35	35	CD
cord-285091-2i2v5ecg	62	24	]	]	-RRB-
cord-285091-2i2v5ecg	62	25	.	.	.
cord-285091-2i2v5ecg	63	1	Our	-PRON-	PRP$
cord-285091-2i2v5ecg	63	2	recent	recent	JJ
cord-285091-2i2v5ecg	63	3	work	work	NN
cord-285091-2i2v5ecg	63	4	demonstrated	demonstrate	VBD
cord-285091-2i2v5ecg	63	5	that	that	IN
cord-285091-2i2v5ecg	63	6	the	the	DT
cord-285091-2i2v5ecg	63	7	activity	activity	NN
cord-285091-2i2v5ecg	63	8	of	of	IN
cord-285091-2i2v5ecg	63	9	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	63	10	L	l	NN
cord-285091-2i2v5ecg	63	11	in	in	IN
cord-285091-2i2v5ecg	63	12	the	the	DT
cord-285091-2i2v5ecg	63	13	nucleus	nucleus	NN
cord-285091-2i2v5ecg	63	14	is	be	VBZ
cord-285091-2i2v5ecg	63	15	regulated	regulate	VBN
cord-285091-2i2v5ecg	63	16	by	by	IN
cord-285091-2i2v5ecg	63	17	a	a	DT
cord-285091-2i2v5ecg	63	18	nuclear	nuclear	JJ
cord-285091-2i2v5ecg	63	19	cystatin	cystatin	NN
cord-285091-2i2v5ecg	63	20	,	,	,
cord-285091-2i2v5ecg	63	21	denoted	denote	VBN
cord-285091-2i2v5ecg	63	22	as	as	IN
cord-285091-2i2v5ecg	63	23	stefin	stefin	NNP
cord-285091-2i2v5ecg	63	24	B	B	NNP
cord-285091-2i2v5ecg	63	25	[	[	-LRB-
cord-285091-2i2v5ecg	63	26	36	36	CD
cord-285091-2i2v5ecg	63	27	]	]	-RRB-
cord-285091-2i2v5ecg	63	28	.	.	.
cord-285091-2i2v5ecg	64	1	The	the	DT
cord-285091-2i2v5ecg	64	2	regulation	regulation	NN
cord-285091-2i2v5ecg	64	3	of	of	IN
cord-285091-2i2v5ecg	64	4	nuclear	nuclear	JJ
cord-285091-2i2v5ecg	64	5	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	64	6	F	F	NNP
cord-285091-2i2v5ecg	64	7	activity	activity	NN
cord-285091-2i2v5ecg	64	8	by	by	IN
cord-285091-2i2v5ecg	64	9	stefin	stefin	NNP
cord-285091-2i2v5ecg	64	10	B	B	NNP
cord-285091-2i2v5ecg	64	11	in	in	IN
cord-285091-2i2v5ecg	64	12	hepatic	hepatic	JJ
cord-285091-2i2v5ecg	64	13	stellate	stellate	JJ
cord-285091-2i2v5ecg	64	14	cells	cell	NNS
cord-285091-2i2v5ecg	64	15	was	be	VBD
cord-285091-2i2v5ecg	64	16	involved	involve	VBN
cord-285091-2i2v5ecg	64	17	in	in	IN
cord-285091-2i2v5ecg	64	18	the	the	DT
cord-285091-2i2v5ecg	64	19	transcriptional	transcriptional	JJ
cord-285091-2i2v5ecg	64	20	regulation	regulation	NN
cord-285091-2i2v5ecg	64	21	of	of	IN
cord-285091-2i2v5ecg	64	22	two	two	CD
cord-285091-2i2v5ecg	64	23	activation	activation	NN
cord-285091-2i2v5ecg	64	24	markers	marker	NNS
cord-285091-2i2v5ecg	64	25	and	and	CC
cord-285091-2i2v5ecg	64	26	implies	imply	VBZ
cord-285091-2i2v5ecg	64	27	the	the	DT
cord-285091-2i2v5ecg	64	28	role	role	NN
cord-285091-2i2v5ecg	64	29	of	of	IN
cord-285091-2i2v5ecg	64	30	stefin	stefin	NNP
cord-285091-2i2v5ecg	64	31	B	B	NNP
cord-285091-2i2v5ecg	64	32	in	in	IN
cord-285091-2i2v5ecg	64	33	transcriptional	transcriptional	JJ
cord-285091-2i2v5ecg	64	34	regulation	regulation	NN
cord-285091-2i2v5ecg	64	35	[	[	-LRB-
cord-285091-2i2v5ecg	64	36	34	34	CD
cord-285091-2i2v5ecg	64	37	]	]	-RRB-
cord-285091-2i2v5ecg	64	38	.	.	.
cord-285091-2i2v5ecg	65	1	The	the	DT
cord-285091-2i2v5ecg	65	2	activity	activity	NN
cord-285091-2i2v5ecg	65	3	of	of	IN
cord-285091-2i2v5ecg	65	4	cathepsins	cathepsin	NNS
cord-285091-2i2v5ecg	65	5	is	be	VBZ
cord-285091-2i2v5ecg	65	6	regulated	regulate	VBN
cord-285091-2i2v5ecg	65	7	by	by	IN
cord-285091-2i2v5ecg	65	8	interaction	interaction	NN
cord-285091-2i2v5ecg	65	9	with	with	IN
cord-285091-2i2v5ecg	65	10	their	-PRON-	PRP$
cord-285091-2i2v5ecg	65	11	endogenous	endogenous	JJ
cord-285091-2i2v5ecg	65	12	protein	protein	NN
cord-285091-2i2v5ecg	65	13	inhibitors	inhibitor	NNS
cord-285091-2i2v5ecg	65	14	:	:	:
cord-285091-2i2v5ecg	65	15	the	the	DT
cord-285091-2i2v5ecg	65	16	cystatins	cystatin	NNS
cord-285091-2i2v5ecg	65	17	[	[	-LRB-
cord-285091-2i2v5ecg	65	18	37	37	CD
cord-285091-2i2v5ecg	65	19	]	]	-RRB-
cord-285091-2i2v5ecg	65	20	[	[	-LRB-
cord-285091-2i2v5ecg	65	21	38	38	CD
cord-285091-2i2v5ecg	65	22	]	]	-RRB-
cord-285091-2i2v5ecg	65	23	[	[	-LRB-
cord-285091-2i2v5ecg	65	24	39	39	CD
cord-285091-2i2v5ecg	65	25	]	]	-RRB-
cord-285091-2i2v5ecg	65	26	,	,	,
cord-285091-2i2v5ecg	65	27	thyropins	thyropin	NNS
cord-285091-2i2v5ecg	65	28	[	[	-LRB-
cord-285091-2i2v5ecg	65	29	40	40	CD
cord-285091-2i2v5ecg	65	30	]	]	-RRB-
cord-285091-2i2v5ecg	65	31	and	and	CC
cord-285091-2i2v5ecg	65	32	some	some	DT
cord-285091-2i2v5ecg	65	33	of	of	IN
cord-285091-2i2v5ecg	65	34	the	the	DT
cord-285091-2i2v5ecg	65	35	serpins	serpin	NNS
cord-285091-2i2v5ecg	65	36	[	[	-LRB-
cord-285091-2i2v5ecg	65	37	41	41	CD
cord-285091-2i2v5ecg	65	38	]	]	-RRB-
cord-285091-2i2v5ecg	65	39	.	.	.
cord-285091-2i2v5ecg	66	1	Thyropins	thyropin	NNS
cord-285091-2i2v5ecg	66	2	are	be	VBP
cord-285091-2i2v5ecg	66	3	a	a	DT
cord-285091-2i2v5ecg	66	4	superfamily	superfamily	NN
cord-285091-2i2v5ecg	66	5	of	of	IN
cord-285091-2i2v5ecg	66	6	inhibitors	inhibitor	NNS
cord-285091-2i2v5ecg	66	7	homologous	homologous	JJ
cord-285091-2i2v5ecg	66	8	to	to	IN
cord-285091-2i2v5ecg	66	9	the	the	DT
cord-285091-2i2v5ecg	66	10	thyroglobulin	thyroglobulin	NNP
cord-285091-2i2v5ecg	66	11	type-1	type-1	NN
cord-285091-2i2v5ecg	66	12	domains	domain	NNS
cord-285091-2i2v5ecg	66	13	[	[	-LRB-
cord-285091-2i2v5ecg	66	14	40	40	CD
cord-285091-2i2v5ecg	66	15	]	]	-RRB-
cord-285091-2i2v5ecg	66	16	.	.	.
cord-285091-2i2v5ecg	67	1	The	the	DT
cord-285091-2i2v5ecg	67	2	best	well	RBS
cord-285091-2i2v5ecg	67	3	characterized	characterize	VBN
cord-285091-2i2v5ecg	67	4	human	human	JJ
cord-285091-2i2v5ecg	67	5	representative	representative	NN
cord-285091-2i2v5ecg	67	6	so	so	RB
cord-285091-2i2v5ecg	67	7	far	far	RB
cord-285091-2i2v5ecg	67	8	is	be	VBZ
cord-285091-2i2v5ecg	67	9	the	the	DT
cord-285091-2i2v5ecg	67	10	MHC	MHC	NNP
cord-285091-2i2v5ecg	67	11	-	-	HYPH
cord-285091-2i2v5ecg	67	12	class	class	NN
cord-285091-2i2v5ecg	67	13	II	II	NNP
cord-285091-2i2v5ecg	67	14	associated	associate	VBN
cord-285091-2i2v5ecg	67	15	invariant	invariant	JJ
cord-285091-2i2v5ecg	67	16	chain	chain	NN
cord-285091-2i2v5ecg	67	17	(	(	-LRB-
cord-285091-2i2v5ecg	67	18	Ii	Ii	NNP
cord-285091-2i2v5ecg	67	19	)	)	-RRB-
cord-285091-2i2v5ecg	67	20	fragment	fragment	NN
cord-285091-2i2v5ecg	67	21	,	,	,
cord-285091-2i2v5ecg	67	22	which	which	WDT
cord-285091-2i2v5ecg	67	23	strongly	strongly	RB
cord-285091-2i2v5ecg	67	24	inhibits	inhibit	VBZ
cord-285091-2i2v5ecg	67	25	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	67	26	L	l	NN
cord-285091-2i2v5ecg	67	27	and	and	CC
cord-285091-2i2v5ecg	67	28	cruzipain	cruzipain	VB
cord-285091-2i2v5ecg	67	29	[	[	-LRB-
cord-285091-2i2v5ecg	67	30	42	42	CD
cord-285091-2i2v5ecg	67	31	]	]	-RRB-
cord-285091-2i2v5ecg	68	1	[	[	-LRB-
cord-285091-2i2v5ecg	68	2	43	43	CD
cord-285091-2i2v5ecg	68	3	]	]	-RRB-
cord-285091-2i2v5ecg	68	4	[	[	-LRB-
cord-285091-2i2v5ecg	68	5	44	44	CD
cord-285091-2i2v5ecg	68	6	]	]	-RRB-
cord-285091-2i2v5ecg	68	7	.	.	.
cord-285091-2i2v5ecg	69	1	Cystatins	cystatin	NNS
cord-285091-2i2v5ecg	69	2	are	be	VBP
cord-285091-2i2v5ecg	69	3	reversible	reversible	JJ
cord-285091-2i2v5ecg	69	4	and	and	CC
cord-285091-2i2v5ecg	69	5	tight	tight	RB
cord-285091-2i2v5ecg	69	6	-	-	HYPH
cord-285091-2i2v5ecg	69	7	binding	bind	VBG
cord-285091-2i2v5ecg	69	8	inhibitors	inhibitor	NNS
cord-285091-2i2v5ecg	69	9	of	of	IN
cord-285091-2i2v5ecg	69	10	papain	papain	NN
cord-285091-2i2v5ecg	69	11	(	(	-LRB-
cord-285091-2i2v5ecg	69	12	C1	C1	NNP
cord-285091-2i2v5ecg	69	13	)	)	-RRB-
cord-285091-2i2v5ecg	69	14	and	and	CC
cord-285091-2i2v5ecg	69	15	legumain	legumain	NNP
cord-285091-2i2v5ecg	69	16	(	(	-LRB-
cord-285091-2i2v5ecg	69	17	C13	C13	NNP
cord-285091-2i2v5ecg	69	18	)	)	-RRB-
cord-285091-2i2v5ecg	69	19	families	family	NNS
cord-285091-2i2v5ecg	69	20	of	of	IN
cord-285091-2i2v5ecg	69	21	cysteine	cysteine	NN
cord-285091-2i2v5ecg	69	22	proteases	protease	NNS
cord-285091-2i2v5ecg	69	23	and	and	CC
cord-285091-2i2v5ecg	69	24	are	be	VBP
cord-285091-2i2v5ecg	69	25	characterized	characterize	VBN
cord-285091-2i2v5ecg	69	26	by	by	IN
cord-285091-2i2v5ecg	69	27	a	a	DT
cord-285091-2i2v5ecg	69	28	strong	strong	JJ
cord-285091-2i2v5ecg	69	29	sequence	sequence	NN
cord-285091-2i2v5ecg	69	30	and	and	CC
cord-285091-2i2v5ecg	69	31	structure	structure	NN
cord-285091-2i2v5ecg	69	32	conservation	conservation	NN
cord-285091-2i2v5ecg	69	33	[	[	-LRB-
cord-285091-2i2v5ecg	69	34	45	45	CD
cord-285091-2i2v5ecg	69	35	]	]	-RRB-
cord-285091-2i2v5ecg	69	36	.	.	.
cord-285091-2i2v5ecg	70	1	The	the	DT
cord-285091-2i2v5ecg	70	2	tertiary	tertiary	JJ
cord-285091-2i2v5ecg	70	3	structures	structure	NNS
cord-285091-2i2v5ecg	70	4	of	of	IN
cord-285091-2i2v5ecg	70	5	cystatins	cystatin	NNS
cord-285091-2i2v5ecg	70	6	are	be	VBP
cord-285091-2i2v5ecg	70	7	conserved	conserve	VBN
cord-285091-2i2v5ecg	70	8	and	and	CC
cord-285091-2i2v5ecg	70	9	exhibit	exhibit	VB
cord-285091-2i2v5ecg	70	10	the	the	DT
cord-285091-2i2v5ecg	70	11	so	so	RB
cord-285091-2i2v5ecg	70	12	called	call	VBN
cord-285091-2i2v5ecg	70	13	"	"	``
cord-285091-2i2v5ecg	70	14	cystatin	cystatin	NN
cord-285091-2i2v5ecg	70	15	fold	fold	NN
cord-285091-2i2v5ecg	70	16	"	"	''
cord-285091-2i2v5ecg	70	17	,	,	,
cord-285091-2i2v5ecg	70	18	which	which	WDT
cord-285091-2i2v5ecg	70	19	is	be	VBZ
cord-285091-2i2v5ecg	70	20	formed	form	VBN
cord-285091-2i2v5ecg	70	21	by	by	IN
cord-285091-2i2v5ecg	70	22	a	a	DT
cord-285091-2i2v5ecg	70	23	five	five	CD
cord-285091-2i2v5ecg	70	24	stranded	stranded	JJ
cord-285091-2i2v5ecg	70	25	anti	anti	JJ
cord-285091-2i2v5ecg	70	26	-	-	JJ
cord-285091-2i2v5ecg	70	27	parallelsheet	parallelsheet	JJ
cord-285091-2i2v5ecg	70	28	wrapped	wrap	VBN
cord-285091-2i2v5ecg	70	29	around	around	IN
cord-285091-2i2v5ecg	70	30	a	a	DT
cord-285091-2i2v5ecg	70	31	five	five	CD
cord-285091-2i2v5ecg	70	32	-	-	HYPH
cord-285091-2i2v5ecg	70	33	turn	turn	NN
cord-285091-2i2v5ecg	70	34	-helix	-helix	VBD
cord-285091-2i2v5ecg	70	35	[	[	-LRB-
cord-285091-2i2v5ecg	70	36	46	46	CD
cord-285091-2i2v5ecg	70	37	,	,	,
cord-285091-2i2v5ecg	70	38	47	47	CD
cord-285091-2i2v5ecg	70	39	]	]	-RRB-
cord-285091-2i2v5ecg	70	40	.	.	.
cord-285091-2i2v5ecg	71	1	The	the	DT
cord-285091-2i2v5ecg	71	2	cystatin	cystatin	NN
cord-285091-2i2v5ecg	71	3	family	family	NN
cord-285091-2i2v5ecg	71	4	I25	I25	NNP
cord-285091-2i2v5ecg	71	5	contains	contain	VBZ
cord-285091-2i2v5ecg	71	6	three	three	CD
cord-285091-2i2v5ecg	71	7	subfamilies	subfamily	NNS
cord-285091-2i2v5ecg	71	8	:	:	:
cord-285091-2i2v5ecg	71	9	I25A	i25a	PRP
cord-285091-2i2v5ecg	71	10	,	,	,
cord-285091-2i2v5ecg	71	11	B	B	NNP
cord-285091-2i2v5ecg	71	12	and	and	CC
cord-285091-2i2v5ecg	71	13	C	C	NNP
cord-285091-2i2v5ecg	71	14	,	,	,
cord-285091-2i2v5ecg	71	15	as	as	IN
cord-285091-2i2v5ecg	71	16	defined	define	VBN
cord-285091-2i2v5ecg	71	17	in	in	IN
cord-285091-2i2v5ecg	71	18	the	the	DT
cord-285091-2i2v5ecg	71	19	MEROPS	MEROPS	NNP
cord-285091-2i2v5ecg	71	20	database	database	NN
cord-285091-2i2v5ecg	71	21	of	of	IN
cord-285091-2i2v5ecg	71	22	protease	protease	NN
cord-285091-2i2v5ecg	71	23	and	and	CC
cord-285091-2i2v5ecg	71	24	protease	protease	NN
cord-285091-2i2v5ecg	71	25	inhibitor	inhibitor	NN
cord-285091-2i2v5ecg	71	26	information	information	NN
cord-285091-2i2v5ecg	71	27	(	(	-LRB-
cord-285091-2i2v5ecg	71	28	http://merops.sanger.ac.uk/	http://merops.sanger.ac.uk/	NNP
cord-285091-2i2v5ecg	71	29	)	)	-RRB-
cord-285091-2i2v5ecg	71	30	[	[	-LRB-
cord-285091-2i2v5ecg	71	31	21	21	CD
cord-285091-2i2v5ecg	71	32	]	]	-RRB-
cord-285091-2i2v5ecg	71	33	.	.	.
cord-285091-2i2v5ecg	72	1	Cystatins	cystatin	NNS
cord-285091-2i2v5ecg	72	2	are	be	VBP
cord-285091-2i2v5ecg	72	3	found	find	VBN
cord-285091-2i2v5ecg	72	4	in	in	IN
cord-285091-2i2v5ecg	72	5	plants	plant	NNS
cord-285091-2i2v5ecg	72	6	,	,	,
cord-285091-2i2v5ecg	72	7	fungi	fungus	NNS
cord-285091-2i2v5ecg	72	8	and	and	CC
cord-285091-2i2v5ecg	72	9	animals	animal	NNS
cord-285091-2i2v5ecg	72	10	as	as	RB
cord-285091-2i2v5ecg	72	11	well	well	RB
cord-285091-2i2v5ecg	72	12	as	as	IN
cord-285091-2i2v5ecg	72	13	in	in	IN
cord-285091-2i2v5ecg	72	14	viruses	virus	NNS
cord-285091-2i2v5ecg	72	15	.	.	.
cord-285091-2i2v5ecg	73	1	Type	type	NN
cord-285091-2i2v5ecg	73	2	1	1	CD
cord-285091-2i2v5ecg	73	3	cystatins	cystatin	NNS
cord-285091-2i2v5ecg	73	4	,	,	,
cord-285091-2i2v5ecg	73	5	denoted	denote	VBN
cord-285091-2i2v5ecg	73	6	as	as	IN
cord-285091-2i2v5ecg	73	7	stefins	stefin	NNS
cord-285091-2i2v5ecg	73	8	,	,	,
cord-285091-2i2v5ecg	73	9	are	be	VBP
cord-285091-2i2v5ecg	73	10	predominantly	predominantly	RB
cord-285091-2i2v5ecg	73	11	present	present	JJ
cord-285091-2i2v5ecg	73	12	in	in	IN
cord-285091-2i2v5ecg	73	13	the	the	DT
cord-285091-2i2v5ecg	73	14	cytosol	cytosol	NN
cord-285091-2i2v5ecg	73	15	and	and	CC
cord-285091-2i2v5ecg	73	16	the	the	DT
cord-285091-2i2v5ecg	73	17	nuclei	nucleus	NNS
cord-285091-2i2v5ecg	73	18	,	,	,
cord-285091-2i2v5ecg	73	19	while	while	IN
cord-285091-2i2v5ecg	73	20	Type	type	NN
cord-285091-2i2v5ecg	73	21	2	2	CD
cord-285091-2i2v5ecg	73	22	cystatins	cystatin	NNS
cord-285091-2i2v5ecg	73	23	are	be	VBP
cord-285091-2i2v5ecg	73	24	mainly	mainly	RB
cord-285091-2i2v5ecg	73	25	extracellular	extracellular	JJ
cord-285091-2i2v5ecg	73	26	,	,	,
cord-285091-2i2v5ecg	73	27	secreted	secrete	VBN
cord-285091-2i2v5ecg	73	28	proteins	protein	NNS
cord-285091-2i2v5ecg	73	29	.	.	.
cord-285091-2i2v5ecg	74	1	These	these	DT
cord-285091-2i2v5ecg	74	2	latter	latter	RB
cord-285091-2i2v5ecg	74	3	are	be	VBP
cord-285091-2i2v5ecg	74	4	synthesized	synthesize	VBN
cord-285091-2i2v5ecg	74	5	with	with	IN
cord-285091-2i2v5ecg	74	6	20	20	CD
cord-285091-2i2v5ecg	74	7	-	-	SYM
cord-285091-2i2v5ecg	74	8	26	26	CD
cord-285091-2i2v5ecg	74	9	residue	residue	NN
cord-285091-2i2v5ecg	74	10	long	long	JJ
cord-285091-2i2v5ecg	74	11	signal	signal	NN
cord-285091-2i2v5ecg	74	12	peptides	peptide	NNS
cord-285091-2i2v5ecg	74	13	,	,	,
cord-285091-2i2v5ecg	74	14	most	most	JJS
cord-285091-2i2v5ecg	74	15	of	of	IN
cord-285091-2i2v5ecg	74	16	them	-PRON-	PRP
cord-285091-2i2v5ecg	74	17	found	find	VBD
cord-285091-2i2v5ecg	74	18	in	in	IN
cord-285091-2i2v5ecg	74	19	physiologically	physiologically	RB
cord-285091-2i2v5ecg	74	20	relevant	relevant	JJ
cord-285091-2i2v5ecg	74	21	concentrations	concentration	NNS
cord-285091-2i2v5ecg	74	22	in	in	IN
cord-285091-2i2v5ecg	74	23	body	body	NN
cord-285091-2i2v5ecg	74	24	fluids	fluid	NNS
cord-285091-2i2v5ecg	74	25	.	.	.
cord-285091-2i2v5ecg	75	1	Type	type	NN
cord-285091-2i2v5ecg	75	2	3	3	CD
cord-285091-2i2v5ecg	75	3	cystatins	cystatin	NNS
cord-285091-2i2v5ecg	75	4	are	be	VBP
cord-285091-2i2v5ecg	75	5	multidomain	multidomain	NN
cord-285091-2i2v5ecg	75	6	proteins	protein	NNS
cord-285091-2i2v5ecg	75	7	of	of	IN
cord-285091-2i2v5ecg	75	8	high	high	JJ
cord-285091-2i2v5ecg	75	9	molecular	molecular	JJ
cord-285091-2i2v5ecg	75	10	mass	mass	NN
cord-285091-2i2v5ecg	75	11	(	(	-LRB-
cord-285091-2i2v5ecg	75	12	60	60	CD
cord-285091-2i2v5ecg	75	13	-	-	SYM
cord-285091-2i2v5ecg	75	14	120	120	CD
cord-285091-2i2v5ecg	75	15	kDa	kDa	NNS
cord-285091-2i2v5ecg	75	16	)	)	-RRB-
cord-285091-2i2v5ecg	75	17	and	and	CC
cord-285091-2i2v5ecg	75	18	present	present	VB
cord-285091-2i2v5ecg	75	19	three	three	CD
cord-285091-2i2v5ecg	75	20	tandemly	tandemly	NN
cord-285091-2i2v5ecg	75	21	repeated	repeat	VBN
cord-285091-2i2v5ecg	75	22	type	type	NN
cord-285091-2i2v5ecg	75	23	2-like	2-like	CD
cord-285091-2i2v5ecg	75	24	cystatin	cystatin	NN
cord-285091-2i2v5ecg	75	25	domains	domain	NNS
cord-285091-2i2v5ecg	75	26	[	[	-LRB-
cord-285091-2i2v5ecg	75	27	48	48	CD
cord-285091-2i2v5ecg	75	28	]	]	-RRB-
cord-285091-2i2v5ecg	75	29	.	.	.
cord-285091-2i2v5ecg	76	1	The	the	DT
cord-285091-2i2v5ecg	76	2	mammalian	mammalian	JJ
cord-285091-2i2v5ecg	76	3	cystatins	cystatin	NNS
cord-285091-2i2v5ecg	76	4	belonging	belong	VBG
cord-285091-2i2v5ecg	76	5	to	to	IN
cord-285091-2i2v5ecg	76	6	this	this	DT
cord-285091-2i2v5ecg	76	7	type	type	NN
cord-285091-2i2v5ecg	76	8	are	be	VBP
cord-285091-2i2v5ecg	76	9	called	call	VBN
cord-285091-2i2v5ecg	76	10	kininogens	kininogens	NNP
cord-285091-2i2v5ecg	76	11	[	[	-LRB-
cord-285091-2i2v5ecg	76	12	49	49	CD
cord-285091-2i2v5ecg	76	13	]	]	-RRB-
cord-285091-2i2v5ecg	76	14	,	,	,
cord-285091-2i2v5ecg	76	15	which	which	WDT
cord-285091-2i2v5ecg	76	16	were	be	VBD
cord-285091-2i2v5ecg	76	17	first	first	RB
cord-285091-2i2v5ecg	76	18	known	know	VBN
cord-285091-2i2v5ecg	76	19	as	as	IN
cord-285091-2i2v5ecg	76	20	kinin	kinin	NNP
cord-285091-2i2v5ecg	76	21	precursor	precursor	NN
cord-285091-2i2v5ecg	76	22	proteins	protein	NNS
cord-285091-2i2v5ecg	76	23	.	.	.
cord-285091-2i2v5ecg	77	1	The	the	DT
cord-285091-2i2v5ecg	77	2	serpins	serpin	NNS
cord-285091-2i2v5ecg	77	3	are	be	VBP
cord-285091-2i2v5ecg	77	4	essentially	essentially	RB
cord-285091-2i2v5ecg	77	5	serine	serine	JJ
cord-285091-2i2v5ecg	77	6	proteinase	proteinase	NN
cord-285091-2i2v5ecg	77	7	inhibitors	inhibitor	NNS
cord-285091-2i2v5ecg	77	8	[	[	-LRB-
cord-285091-2i2v5ecg	77	9	50	50	CD
cord-285091-2i2v5ecg	77	10	,	,	,
cord-285091-2i2v5ecg	77	11	51	51	CD
cord-285091-2i2v5ecg	77	12	]	]	-RRB-
cord-285091-2i2v5ecg	77	13	,	,	,
cord-285091-2i2v5ecg	77	14	only	only	RB
cord-285091-2i2v5ecg	77	15	some	some	DT
cord-285091-2i2v5ecg	77	16	of	of	IN
cord-285091-2i2v5ecg	77	17	them	-PRON-	PRP
cord-285091-2i2v5ecg	77	18	inhibit	inhibit	VBP
cord-285091-2i2v5ecg	77	19	both	both	CC
cord-285091-2i2v5ecg	77	20	serine	serine	NN
cord-285091-2i2v5ecg	77	21	and	and	CC
cord-285091-2i2v5ecg	77	22	cysteine	cysteine	NN
cord-285091-2i2v5ecg	77	23	proteases	protease	NNS
cord-285091-2i2v5ecg	77	24	[	[	-LRB-
cord-285091-2i2v5ecg	77	25	41	41	CD
cord-285091-2i2v5ecg	77	26	]	]	-RRB-
cord-285091-2i2v5ecg	77	27	.	.	.
cord-285091-2i2v5ecg	78	1	The	the	DT
cord-285091-2i2v5ecg	78	2	mechanism	mechanism	NN
cord-285091-2i2v5ecg	78	3	by	by	IN
cord-285091-2i2v5ecg	78	4	which	which	WDT
cord-285091-2i2v5ecg	78	5	cysteine	cysteine	NN
cord-285091-2i2v5ecg	78	6	proteases	protease	NNS
cord-285091-2i2v5ecg	78	7	are	be	VBP
cord-285091-2i2v5ecg	78	8	inhibited	inhibit	VBN
cord-285091-2i2v5ecg	78	9	involves	involve	VBZ
cord-285091-2i2v5ecg	78	10	the	the	DT
cord-285091-2i2v5ecg	78	11	cleavage	cleavage	NN
cord-285091-2i2v5ecg	78	12	of	of	IN
cord-285091-2i2v5ecg	78	13	the	the	DT
cord-285091-2i2v5ecg	78	14	serpin	serpin	NN
cord-285091-2i2v5ecg	78	15	,	,	,
cord-285091-2i2v5ecg	78	16	in	in	IN
cord-285091-2i2v5ecg	78	17	some	some	DT
cord-285091-2i2v5ecg	78	18	cases	case	NNS
cord-285091-2i2v5ecg	78	19	involving	involve	VBG
cord-285091-2i2v5ecg	78	20	a	a	DT
cord-285091-2i2v5ecg	78	21	stable	stable	JJ
cord-285091-2i2v5ecg	78	22	covalent	covalent	JJ
cord-285091-2i2v5ecg	78	23	complex	complex	NN
cord-285091-2i2v5ecg	78	24	[	[	-LRB-
cord-285091-2i2v5ecg	78	25	52	52	CD
cord-285091-2i2v5ecg	78	26	]	]	-RRB-
cord-285091-2i2v5ecg	79	1	[	[	-LRB-
cord-285091-2i2v5ecg	79	2	53	53	CD
cord-285091-2i2v5ecg	79	3	]	]	-RRB-
cord-285091-2i2v5ecg	79	4	[	[	-LRB-
cord-285091-2i2v5ecg	79	5	54	54	CD
cord-285091-2i2v5ecg	79	6	]	]	-RRB-
cord-285091-2i2v5ecg	79	7	and	and	CC
cord-285091-2i2v5ecg	79	8	in	in	IN
cord-285091-2i2v5ecg	79	9	other	other	JJ
cord-285091-2i2v5ecg	79	10	cases	case	NNS
cord-285091-2i2v5ecg	79	11	not	not	RB
cord-285091-2i2v5ecg	79	12	[	[	-LRB-
cord-285091-2i2v5ecg	79	13	55	55	CD
cord-285091-2i2v5ecg	79	14	]	]	-RRB-
cord-285091-2i2v5ecg	79	15	.	.	.
cord-285091-2i2v5ecg	80	1	Macrophages	macrophage	NNS
cord-285091-2i2v5ecg	80	2	play	play	VBP
cord-285091-2i2v5ecg	80	3	a	a	DT
cord-285091-2i2v5ecg	80	4	critical	critical	JJ
cord-285091-2i2v5ecg	80	5	role	role	NN
cord-285091-2i2v5ecg	80	6	in	in	IN
cord-285091-2i2v5ecg	80	7	host	host	NN
cord-285091-2i2v5ecg	80	8	defense	defense	NN
cord-285091-2i2v5ecg	80	9	against	against	IN
cord-285091-2i2v5ecg	80	10	pathogens	pathogen	NNS
cord-285091-2i2v5ecg	80	11	and	and	CC
cord-285091-2i2v5ecg	80	12	are	be	VBP
cord-285091-2i2v5ecg	80	13	present	present	JJ
cord-285091-2i2v5ecg	80	14	in	in	IN
cord-285091-2i2v5ecg	80	15	virtually	virtually	RB
cord-285091-2i2v5ecg	80	16	all	all	DT
cord-285091-2i2v5ecg	80	17	tissues	tissue	NNS
cord-285091-2i2v5ecg	80	18	[	[	-LRB-
cord-285091-2i2v5ecg	80	19	56	56	CD
cord-285091-2i2v5ecg	80	20	]	]	-RRB-
cord-285091-2i2v5ecg	80	21	.	.	.
cord-285091-2i2v5ecg	81	1	They	-PRON-	PRP
cord-285091-2i2v5ecg	81	2	can	can	MD
cord-285091-2i2v5ecg	81	3	change	change	VB
cord-285091-2i2v5ecg	81	4	their	-PRON-	PRP$
cord-285091-2i2v5ecg	81	5	physiology	physiology	NN
cord-285091-2i2v5ecg	81	6	in	in	IN
cord-285091-2i2v5ecg	81	7	response	response	NN
cord-285091-2i2v5ecg	81	8	to	to	TO
cord-285091-2i2v5ecg	81	9	microenvironmental	microenvironmental	VB
cord-285091-2i2v5ecg	81	10	stimuli	stimulus	NNS
cord-285091-2i2v5ecg	81	11	.	.	.
cord-285091-2i2v5ecg	82	1	Classically	classically	RB
cord-285091-2i2v5ecg	82	2	activated	activate	VBN
cord-285091-2i2v5ecg	82	3	macrophages	macrophage	NNS
cord-285091-2i2v5ecg	82	4	or	or	CC
cord-285091-2i2v5ecg	82	5	M1	M1	NNP
cord-285091-2i2v5ecg	82	6	,	,	,
cord-285091-2i2v5ecg	82	7	primed	prime	VBN
cord-285091-2i2v5ecg	82	8	with	with	IN
cord-285091-2i2v5ecg	82	9	IFN	IFN	NNP
cord-285091-2i2v5ecg	82	10	-	-	,
cord-285091-2i2v5ecg	82	11	and	and	CC
cord-285091-2i2v5ecg	82	12	stimulated	stimulate	VBD
cord-285091-2i2v5ecg	82	13	with	with	IN
cord-285091-2i2v5ecg	82	14	LPS	LPS	NNP
cord-285091-2i2v5ecg	82	15	,	,	,
cord-285091-2i2v5ecg	82	16	are	be	VBP
cord-285091-2i2v5ecg	82	17	involved	involve	VBN
cord-285091-2i2v5ecg	82	18	in	in	IN
cord-285091-2i2v5ecg	82	19	inflammatory	inflammatory	JJ
cord-285091-2i2v5ecg	82	20	responses	response	NNS
cord-285091-2i2v5ecg	82	21	to	to	IN
cord-285091-2i2v5ecg	82	22	bacterial	bacterial	JJ
cord-285091-2i2v5ecg	82	23	and	and	CC
cord-285091-2i2v5ecg	82	24	viral	viral	JJ
cord-285091-2i2v5ecg	82	25	infection	infection	NN
cord-285091-2i2v5ecg	82	26	[	[	-LRB-
cord-285091-2i2v5ecg	82	27	57	57	CD
cord-285091-2i2v5ecg	82	28	]	]	-RRB-
cord-285091-2i2v5ecg	82	29	.	.	.
cord-285091-2i2v5ecg	83	1	Stimulation	stimulation	NN
cord-285091-2i2v5ecg	83	2	of	of	IN
cord-285091-2i2v5ecg	83	3	macrophages	macrophage	NNS
cord-285091-2i2v5ecg	83	4	with	with	IN
cord-285091-2i2v5ecg	83	5	the	the	DT
cord-285091-2i2v5ecg	83	6	cytokines	cytokine	NNS
cord-285091-2i2v5ecg	83	7	interleukin	interleukin	NN
cord-285091-2i2v5ecg	83	8	4	4	CD
cord-285091-2i2v5ecg	83	9	(	(	-LRB-
cord-285091-2i2v5ecg	83	10	IL-4	IL-4	NNP
cord-285091-2i2v5ecg	83	11	)	)	-RRB-
cord-285091-2i2v5ecg	83	12	or	or	CC
cord-285091-2i2v5ecg	83	13	IL-13	IL-13	NNP
cord-285091-2i2v5ecg	83	14	induces	induce	VBZ
cord-285091-2i2v5ecg	83	15	alternatively	alternatively	RB
cord-285091-2i2v5ecg	83	16	activated	activate	VBN
cord-285091-2i2v5ecg	83	17	(	(	-LRB-
cord-285091-2i2v5ecg	83	18	called	call	VBN
cord-285091-2i2v5ecg	83	19	M2	M2	NNP
cord-285091-2i2v5ecg	83	20	)	)	-RRB-
cord-285091-2i2v5ecg	83	21	macrophages	macrophage	NNS
cord-285091-2i2v5ecg	83	22	[	[	-LRB-
cord-285091-2i2v5ecg	83	23	58	58	CD
cord-285091-2i2v5ecg	83	24	]	]	-RRB-
cord-285091-2i2v5ecg	83	25	[	[	-LRB-
cord-285091-2i2v5ecg	83	26	59	59	CD
cord-285091-2i2v5ecg	83	27	]	]	-RRB-
cord-285091-2i2v5ecg	84	1	[	[	-LRB-
cord-285091-2i2v5ecg	84	2	60	60	CD
cord-285091-2i2v5ecg	84	3	]	]	-RRB-
cord-285091-2i2v5ecg	84	4	.	.	.
cord-285091-2i2v5ecg	85	1	The	the	DT
cord-285091-2i2v5ecg	85	2	M2	M2	NNP
cord-285091-2i2v5ecg	85	3	macrophages	macrophage	NNS
cord-285091-2i2v5ecg	85	4	include	include	VBP
cord-285091-2i2v5ecg	85	5	several	several	JJ
cord-285091-2i2v5ecg	85	6	types	type	NNS
cord-285091-2i2v5ecg	85	7	of	of	IN
cord-285091-2i2v5ecg	85	8	activated	activate	VBN
cord-285091-2i2v5ecg	85	9	macrophages	macrophage	NNS
cord-285091-2i2v5ecg	85	10	,	,	,
cord-285091-2i2v5ecg	85	11	not	not	RB
cord-285091-2i2v5ecg	85	12	only	only	RB
cord-285091-2i2v5ecg	85	13	wound	wound	VB
cord-285091-2i2v5ecg	85	14	healing	healing	NN
cord-285091-2i2v5ecg	85	15	macrophages	macrophage	NNS
cord-285091-2i2v5ecg	85	16	,	,	,
cord-285091-2i2v5ecg	85	17	but	but	CC
cord-285091-2i2v5ecg	85	18	also	also	RB
cord-285091-2i2v5ecg	85	19	regulatory	regulatory	JJ
cord-285091-2i2v5ecg	85	20	macrophages	macrophage	NNS
cord-285091-2i2v5ecg	85	21	and	and	CC
cord-285091-2i2v5ecg	85	22	tumor	tumor	NN
cord-285091-2i2v5ecg	85	23	-	-	HYPH
cord-285091-2i2v5ecg	85	24	associated	associate	VBN
cord-285091-2i2v5ecg	85	25	macrophages	macrophage	NNS
cord-285091-2i2v5ecg	85	26	.	.	.
cord-285091-2i2v5ecg	86	1	Regulatory	regulatory	JJ
cord-285091-2i2v5ecg	86	2	macrophages	macrophage	NNS
cord-285091-2i2v5ecg	86	3	can	can	MD
cord-285091-2i2v5ecg	86	4	secrete	secrete	VB
cord-285091-2i2v5ecg	86	5	large	large	JJ
cord-285091-2i2v5ecg	86	6	amounts	amount	NNS
cord-285091-2i2v5ecg	86	7	of	of	IN
cord-285091-2i2v5ecg	86	8	interleukin-10	interleukin-10	NN
cord-285091-2i2v5ecg	86	9	(	(	-LRB-
cord-285091-2i2v5ecg	86	10	IL-10	IL-10	NNP
cord-285091-2i2v5ecg	86	11	)	)	-RRB-
cord-285091-2i2v5ecg	87	1	in	in	IN
cord-285091-2i2v5ecg	87	2	response	response	NN
cord-285091-2i2v5ecg	87	3	to	to	IN
cord-285091-2i2v5ecg	87	4	Fc	Fc	NNP
cord-285091-2i2v5ecg	87	5	receptor	receptor	NN
cord-285091-2i2v5ecg	87	6	-	-	HYPH
cord-285091-2i2v5ecg	87	7	ligation	ligation	NN
cord-285091-2i2v5ecg	87	8	[	[	-LRB-
cord-285091-2i2v5ecg	87	9	61	61	CD
cord-285091-2i2v5ecg	87	10	,	,	,
cord-285091-2i2v5ecg	87	11	62	62	CD
cord-285091-2i2v5ecg	87	12	]	]	-RRB-
cord-285091-2i2v5ecg	87	13	.	.	.
cord-285091-2i2v5ecg	88	1	M1	M1	NNP
cord-285091-2i2v5ecg	88	2	macrophages	macrophage	NNS
cord-285091-2i2v5ecg	88	3	produce	produce	VBP
cord-285091-2i2v5ecg	88	4	high	high	JJ
cord-285091-2i2v5ecg	88	5	amounts	amount	NNS
cord-285091-2i2v5ecg	88	6	of	of	IN
cord-285091-2i2v5ecg	88	7	proinflammatory	proinflammatory	JJ
cord-285091-2i2v5ecg	88	8	cytokines	cytokine	NNS
cord-285091-2i2v5ecg	88	9	,	,	,
cord-285091-2i2v5ecg	88	10	such	such	JJ
cord-285091-2i2v5ecg	88	11	as	as	IN
cord-285091-2i2v5ecg	88	12	tumor	tumor	NN
cord-285091-2i2v5ecg	88	13	necrosis	necrosis	NN
cord-285091-2i2v5ecg	88	14	factor	factor	NN
cord-285091-2i2v5ecg	88	15	alpha	alpha	NN
cord-285091-2i2v5ecg	88	16	(	(	-LRB-
cord-285091-2i2v5ecg	88	17	TNF-	TNF-	NNP
cord-285091-2i2v5ecg	88	18	)	)	-RRB-
cord-285091-2i2v5ecg	88	19	,	,	,
cord-285091-2i2v5ecg	88	20	upon	upon	IN
cord-285091-2i2v5ecg	88	21	recognition	recognition	NN
cord-285091-2i2v5ecg	88	22	of	of	IN
cord-285091-2i2v5ecg	88	23	invading	invade	VBG
cord-285091-2i2v5ecg	88	24	pathogens	pathogen	NNS
cord-285091-2i2v5ecg	88	25	by	by	IN
cord-285091-2i2v5ecg	88	26	a	a	DT
cord-285091-2i2v5ecg	88	27	set	set	NN
cord-285091-2i2v5ecg	88	28	of	of	IN
cord-285091-2i2v5ecg	88	29	PRRs	prr	NNS
cord-285091-2i2v5ecg	88	30	including	include	VBG
cord-285091-2i2v5ecg	88	31	TLRs	TLRs	NNP
cord-285091-2i2v5ecg	88	32	,	,	,
cord-285091-2i2v5ecg	88	33	RLRs	rlr	NNS
cord-285091-2i2v5ecg	88	34	and	and	CC
cord-285091-2i2v5ecg	88	35	NLRs	nlr	NNS
cord-285091-2i2v5ecg	88	36	.	.	.
cord-285091-2i2v5ecg	89	1	M1	M1	NNP
cord-285091-2i2v5ecg	89	2	macrophages	macrophage	NNS
cord-285091-2i2v5ecg	89	3	are	be	VBP
cord-285091-2i2v5ecg	89	4	known	know	VBN
cord-285091-2i2v5ecg	89	5	to	to	TO
cord-285091-2i2v5ecg	89	6	produce	produce	VB
cord-285091-2i2v5ecg	89	7	nitric	nitric	NN
cord-285091-2i2v5ecg	89	8	oxide	oxide	NN
cord-285091-2i2v5ecg	89	9	(	(	-LRB-
cord-285091-2i2v5ecg	89	10	NO	no	UH
cord-285091-2i2v5ecg	89	11	)	)	-RRB-
cord-285091-2i2v5ecg	89	12	by	by	IN
cord-285091-2i2v5ecg	89	13	expressing	express	VBG
cord-285091-2i2v5ecg	89	14	inducible	inducible	JJ
cord-285091-2i2v5ecg	89	15	NO	no	DT
cord-285091-2i2v5ecg	89	16	synthase	synthase	NN
cord-285091-2i2v5ecg	89	17	(	(	-LRB-
cord-285091-2i2v5ecg	89	18	iNOS	inos	NN
cord-285091-2i2v5ecg	89	19	)	)	-RRB-
cord-285091-2i2v5ecg	89	20	and	and	CC
cord-285091-2i2v5ecg	89	21	are	be	VBP
cord-285091-2i2v5ecg	89	22	critical	critical	JJ
cord-285091-2i2v5ecg	89	23	for	for	IN
cord-285091-2i2v5ecg	89	24	clearing	clear	VBG
cord-285091-2i2v5ecg	89	25	bacterial	bacterial	JJ
cord-285091-2i2v5ecg	89	26	,	,	,
cord-285091-2i2v5ecg	89	27	viral	viral	JJ
cord-285091-2i2v5ecg	89	28	and	and	CC
cord-285091-2i2v5ecg	89	29	fungal	fungal	JJ
cord-285091-2i2v5ecg	89	30	infections	infection	NNS
cord-285091-2i2v5ecg	89	31	.	.	.
cord-285091-2i2v5ecg	90	1	Early	early	JJ
cord-285091-2i2v5ecg	90	2	studies	study	NNS
cord-285091-2i2v5ecg	90	3	reported	report	VBD
cord-285091-2i2v5ecg	90	4	that	that	IN
cord-285091-2i2v5ecg	90	5	macrophages	macrophage	NNS
cord-285091-2i2v5ecg	90	6	activated	activate	VBN
cord-285091-2i2v5ecg	90	7	with	with	IN
cord-285091-2i2v5ecg	90	8	IFN	IFN	NNP
cord-285091-2i2v5ecg	90	9	-	-	:
cord-285091-2i2v5ecg	90	10	and	and	CC
cord-285091-2i2v5ecg	90	11	stimulated	stimulate	VBD
cord-285091-2i2v5ecg	90	12	with	with	IN
cord-285091-2i2v5ecg	90	13	IFNchicken	ifnchicken	JJ
cord-285091-2i2v5ecg	90	14	cystatin	cystatin	NN
cord-285091-2i2v5ecg	90	15	generated	generate	VBD
cord-285091-2i2v5ecg	90	16	increased	increase	VBN
cord-285091-2i2v5ecg	90	17	amounts	amount	NNS
cord-285091-2i2v5ecg	90	18	of	of	IN
cord-285091-2i2v5ecg	90	19	NO	no	NN
cord-285091-2i2v5ecg	90	20	and	and	CC
cord-285091-2i2v5ecg	90	21	the	the	DT
cord-285091-2i2v5ecg	90	22	cytokines	cytokine	NNS
cord-285091-2i2v5ecg	90	23	TNF	TNF	NNP
cord-285091-2i2v5ecg	90	24	-	-	:
cord-285091-2i2v5ecg	90	25	and	and	CC
cord-285091-2i2v5ecg	90	26	interleukin	interleukin	NN
cord-285091-2i2v5ecg	90	27	10	10	CD
cord-285091-2i2v5ecg	90	28	(	(	-LRB-
cord-285091-2i2v5ecg	90	29	IL-10	IL-10	NNP
cord-285091-2i2v5ecg	90	30	)	)	-RRB-
cord-285091-2i2v5ecg	90	31	,	,	,
cord-285091-2i2v5ecg	90	32	in	in	IN
cord-285091-2i2v5ecg	90	33	comparison	comparison	NN
cord-285091-2i2v5ecg	90	34	with	with	IN
cord-285091-2i2v5ecg	90	35	macrophages	macrophage	NNS
cord-285091-2i2v5ecg	90	36	activated	activate	VBN
cord-285091-2i2v5ecg	90	37	only	only	RB
cord-285091-2i2v5ecg	90	38	with	with	IN
cord-285091-2i2v5ecg	90	39	IFN-	IFN-	NNP
cord-285091-2i2v5ecg	90	40	[	[	-LRB-
cord-285091-2i2v5ecg	90	41	63	63	CD
cord-285091-2i2v5ecg	90	42	,	,	,
cord-285091-2i2v5ecg	90	43	64	64	CD
cord-285091-2i2v5ecg	90	44	]	]	-RRB-
cord-285091-2i2v5ecg	90	45	.	.	.
cord-285091-2i2v5ecg	91	1	Experiments	experiment	NNS
cord-285091-2i2v5ecg	91	2	on	on	IN
cord-285091-2i2v5ecg	91	3	macrophages	macrophage	NNS
cord-285091-2i2v5ecg	91	4	prepared	prepare	VBN
cord-285091-2i2v5ecg	91	5	from	from	IN
cord-285091-2i2v5ecg	91	6	cystatin	cystatin	NNP
cord-285091-2i2v5ecg	92	1	Cdeficient	Cdeficient	NNP
cord-285091-2i2v5ecg	92	2	mice	mouse	NNS
cord-285091-2i2v5ecg	92	3	revealed	reveal	VBD
cord-285091-2i2v5ecg	92	4	that	that	IN
cord-285091-2i2v5ecg	92	5	IFN	IFN	NNP
cord-285091-2i2v5ecg	92	6	--	--	:
cord-285091-2i2v5ecg	92	7	primed	prime	VBD
cord-285091-2i2v5ecg	92	8	cystatin	cystatin	NN
cord-285091-2i2v5ecg	93	1	Cdeficient	cdeficient	NN
cord-285091-2i2v5ecg	93	2	macrophages	macrophage	NNS
cord-285091-2i2v5ecg	93	3	exhibit	exhibit	VBP
cord-285091-2i2v5ecg	93	4	significantly	significantly	RB
cord-285091-2i2v5ecg	93	5	higher	high	JJR
cord-285091-2i2v5ecg	93	6	IL-10	IL-10	NNP
cord-285091-2i2v5ecg	93	7	but	but	CC
cord-285091-2i2v5ecg	93	8	lower	low	JJR
cord-285091-2i2v5ecg	93	9	TNF	tnf	NN
cord-285091-2i2v5ecg	93	10	-	-	HYPH
cord-285091-2i2v5ecg	93	11	expression	expression	NN
cord-285091-2i2v5ecg	93	12	,	,	,
cord-285091-2i2v5ecg	93	13	compared	compare	VBN
cord-285091-2i2v5ecg	93	14	to	to	IN
cord-285091-2i2v5ecg	93	15	similarly	similarly	RB
cord-285091-2i2v5ecg	93	16	primed	prime	VBN
cord-285091-2i2v5ecg	93	17	wild	wild	JJ
cord-285091-2i2v5ecg	93	18	type	type	NN
cord-285091-2i2v5ecg	93	19	macrophages	macrophage	NNS
cord-285091-2i2v5ecg	93	20	[	[	-LRB-
cord-285091-2i2v5ecg	93	21	65	65	CD
cord-285091-2i2v5ecg	93	22	]	]	-RRB-
cord-285091-2i2v5ecg	93	23	.	.	.
cord-285091-2i2v5ecg	94	1	Upon	upon	IN
cord-285091-2i2v5ecg	94	2	the	the	DT
cord-285091-2i2v5ecg	94	3	classical	classical	JJ
cord-285091-2i2v5ecg	94	4	activation	activation	NN
cord-285091-2i2v5ecg	94	5	mechanism	mechanism	NN
cord-285091-2i2v5ecg	94	6	,	,	,
cord-285091-2i2v5ecg	94	7	macrophages	macrophage	VBZ
cord-285091-2i2v5ecg	94	8	up	up	RP
cord-285091-2i2v5ecg	94	9	-	-	HYPH
cord-285091-2i2v5ecg	94	10	regulate	regulate	VB
cord-285091-2i2v5ecg	94	11	a	a	DT
cord-285091-2i2v5ecg	94	12	variety	variety	NN
cord-285091-2i2v5ecg	94	13	of	of	IN
cord-285091-2i2v5ecg	94	14	proteinases	proteinase	NNS
cord-285091-2i2v5ecg	94	15	that	that	WDT
cord-285091-2i2v5ecg	94	16	can	can	MD
cord-285091-2i2v5ecg	94	17	degrade	degrade	VB
cord-285091-2i2v5ecg	94	18	endocytosed	endocytosed	JJ
cord-285091-2i2v5ecg	94	19	pathogens	pathogen	NNS
cord-285091-2i2v5ecg	94	20	and	and	CC
cord-285091-2i2v5ecg	94	21	play	play	VB
cord-285091-2i2v5ecg	94	22	a	a	DT
cord-285091-2i2v5ecg	94	23	critical	critical	JJ
cord-285091-2i2v5ecg	94	24	role	role	NN
cord-285091-2i2v5ecg	94	25	in	in	IN
cord-285091-2i2v5ecg	94	26	antigen	antigen	NN
cord-285091-2i2v5ecg	94	27	processing	processing	NN
cord-285091-2i2v5ecg	94	28	and	and	CC
cord-285091-2i2v5ecg	94	29	presentation	presentation	NN
cord-285091-2i2v5ecg	94	30	.	.	.
cord-285091-2i2v5ecg	95	1	The	the	DT
cord-285091-2i2v5ecg	95	2	role	role	NN
cord-285091-2i2v5ecg	95	3	of	of	IN
cord-285091-2i2v5ecg	95	4	endosomal	endosomal	NNP
cord-285091-2i2v5ecg	95	5	cathepsins	cathepsins	NNP
cord-285091-2i2v5ecg	95	6	has	have	VBZ
cord-285091-2i2v5ecg	95	7	been	be	VBN
cord-285091-2i2v5ecg	95	8	described	describe	VBN
cord-285091-2i2v5ecg	95	9	in	in	IN
cord-285091-2i2v5ecg	95	10	several	several	JJ
cord-285091-2i2v5ecg	95	11	extensive	extensive	JJ
cord-285091-2i2v5ecg	95	12	reviews	review	NNS
cord-285091-2i2v5ecg	95	13	[	[	-LRB-
cord-285091-2i2v5ecg	95	14	66	66	CD
cord-285091-2i2v5ecg	95	15	,	,	,
cord-285091-2i2v5ecg	95	16	67	67	CD
cord-285091-2i2v5ecg	95	17	]	]	-RRB-
cord-285091-2i2v5ecg	95	18	.	.	.
cord-285091-2i2v5ecg	96	1	Only	only	RB
cord-285091-2i2v5ecg	96	2	some	some	DT
cord-285091-2i2v5ecg	96	3	of	of	IN
cord-285091-2i2v5ecg	96	4	the	the	DT
cord-285091-2i2v5ecg	96	5	endogenous	endogenous	JJ
cord-285091-2i2v5ecg	96	6	inhibitors	inhibitor	NNS
cord-285091-2i2v5ecg	96	7	(	(	-LRB-
cord-285091-2i2v5ecg	96	8	cystatin	cystatin	NNP
cord-285091-2i2v5ecg	96	9	F	F	NNP
cord-285091-2i2v5ecg	96	10	and	and	CC
cord-285091-2i2v5ecg	96	11	Spia3	Spia3	NNP
cord-285091-2i2v5ecg	96	12	g	g	NNP
cord-285091-2i2v5ecg	96	13	)	)	-RRB-
cord-285091-2i2v5ecg	96	14	are	be	VBP
cord-285091-2i2v5ecg	96	15	also	also	RB
cord-285091-2i2v5ecg	96	16	up	up	RB
cord-285091-2i2v5ecg	96	17	regulated	regulate	VBN
cord-285091-2i2v5ecg	96	18	,	,	,
cord-285091-2i2v5ecg	96	19	while	while	IN
cord-285091-2i2v5ecg	96	20	cystatin	cystatin	NNP
cord-285091-2i2v5ecg	96	21	C	C	NNP
cord-285091-2i2v5ecg	96	22	is	be	VBZ
cord-285091-2i2v5ecg	96	23	down	down	RB
cord-285091-2i2v5ecg	96	24	regulated	regulate	VBN
cord-285091-2i2v5ecg	96	25	[	[	-LRB-
cord-285091-2i2v5ecg	96	26	65	65	CD
cord-285091-2i2v5ecg	96	27	,	,	,
cord-285091-2i2v5ecg	96	28	68	68	CD
cord-285091-2i2v5ecg	96	29	]	]	-RRB-
cord-285091-2i2v5ecg	96	30	.	.	.
cord-285091-2i2v5ecg	97	1	Ser	ser	JJ
cord-285091-2i2v5ecg	97	2	-	-	HYPH
cord-285091-2i2v5ecg	97	3	pina3	pina3	NN
cord-285091-2i2v5ecg	97	4	g	g	NN
cord-285091-2i2v5ecg	97	5	(	(	-LRB-
cord-285091-2i2v5ecg	97	6	Spia3	Spia3	NNP
cord-285091-2i2v5ecg	97	7	g	g	NNP
cord-285091-2i2v5ecg	97	8	)	)	-RRB-
cord-285091-2i2v5ecg	97	9	is	be	VBZ
cord-285091-2i2v5ecg	97	10	highly	highly	RB
cord-285091-2i2v5ecg	97	11	induced	induce	VBN
cord-285091-2i2v5ecg	97	12	in	in	IN
cord-285091-2i2v5ecg	97	13	macrophages	macrophage	NNS
cord-285091-2i2v5ecg	97	14	during	during	IN
cord-285091-2i2v5ecg	97	15	bacillus	bacillus	NN
cord-285091-2i2v5ecg	97	16	Calmette	Calmette	NNP
cord-285091-2i2v5ecg	97	17	-	-	HYPH
cord-285091-2i2v5ecg	97	18	Guérin	Guérin	NNP
cord-285091-2i2v5ecg	97	19	infection	infection	NN
cord-285091-2i2v5ecg	97	20	as	as	RB
cord-285091-2i2v5ecg	97	21	well	well	RB
cord-285091-2i2v5ecg	97	22	as	as	IN
cord-285091-2i2v5ecg	97	23	in	in	IN
cord-285091-2i2v5ecg	97	24	infection	infection	NN
cord-285091-2i2v5ecg	97	25	with	with	IN
cord-285091-2i2v5ecg	97	26	Salmonella	Salmonella	NNP
cord-285091-2i2v5ecg	97	27	typhimurium	typhimurium	NN
cord-285091-2i2v5ecg	97	28	and	and	CC
cord-285091-2i2v5ecg	97	29	Listeria	Listeria	NNP
cord-285091-2i2v5ecg	97	30	monocytogenes	monocytogene	NNS
cord-285091-2i2v5ecg	97	31	[	[	-LRB-
cord-285091-2i2v5ecg	97	32	68	68	CD
cord-285091-2i2v5ecg	97	33	]	]	-RRB-
cord-285091-2i2v5ecg	97	34	.	.	.
cord-285091-2i2v5ecg	98	1	It	-PRON-	PRP
cord-285091-2i2v5ecg	98	2	was	be	VBD
cord-285091-2i2v5ecg	98	3	demonstrated	demonstrate	VBN
cord-285091-2i2v5ecg	98	4	that	that	IN
cord-285091-2i2v5ecg	98	5	a	a	DT
cord-285091-2i2v5ecg	98	6	ubiquitin	ubiquitin	JJ
cord-285091-2i2v5ecg	98	7	homolog	homolog	NN
cord-285091-2i2v5ecg	98	8	,	,	,
cord-285091-2i2v5ecg	98	9	IFNstimulated	ifnstimulate	VBN
cord-285091-2i2v5ecg	98	10	gene	gene	NN
cord-285091-2i2v5ecg	98	11	of	of	IN
cord-285091-2i2v5ecg	98	12	15-kDa	15-kda	CD
cord-285091-2i2v5ecg	98	13	(	(	-LRB-
cord-285091-2i2v5ecg	98	14	ISG15	isg15	NN
cord-285091-2i2v5ecg	98	15	)	)	-RRB-
cord-285091-2i2v5ecg	98	16	is	be	VBZ
cord-285091-2i2v5ecg	98	17	conjugated	conjugate	VBN
cord-285091-2i2v5ecg	98	18	to	to	TO
cord-285091-2i2v5ecg	98	19	Spia3	spia3	VB
cord-285091-2i2v5ecg	98	20	g	g	NN
cord-285091-2i2v5ecg	98	21	in	in	IN
cord-285091-2i2v5ecg	98	22	activated	activate	VBN
cord-285091-2i2v5ecg	98	23	macrophages	macrophage	NNS
cord-285091-2i2v5ecg	98	24	.	.	.
cord-285091-2i2v5ecg	99	1	It	-PRON-	PRP
cord-285091-2i2v5ecg	99	2	was	be	VBD
cord-285091-2i2v5ecg	99	3	reported	report	VBN
cord-285091-2i2v5ecg	99	4	that	that	IN
cord-285091-2i2v5ecg	99	5	the	the	DT
cord-285091-2i2v5ecg	99	6	stimulation	stimulation	NN
cord-285091-2i2v5ecg	99	7	of	of	IN
cord-285091-2i2v5ecg	99	8	murine	murine	JJ
cord-285091-2i2v5ecg	99	9	macrophages	macrophage	NNS
cord-285091-2i2v5ecg	99	10	with	with	IN
cord-285091-2i2v5ecg	99	11	IFN	IFN	NNP
cord-285091-2i2v5ecg	99	12	-	-	HYPH
cord-285091-2i2v5ecg	99	13	resulted	result	VBD
cord-285091-2i2v5ecg	99	14	in	in	IN
cord-285091-2i2v5ecg	99	15	increased	increase	VBN
cord-285091-2i2v5ecg	99	16	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	99	17	S	s	NN
cord-285091-2i2v5ecg	99	18	activity	activity	NN
cord-285091-2i2v5ecg	99	19	and	and	CC
cord-285091-2i2v5ecg	99	20	down	down	IN
cord-285091-2i2v5ecg	99	21	-	-	HYPH
cord-285091-2i2v5ecg	99	22	regulation	regulation	NN
cord-285091-2i2v5ecg	99	23	of	of	IN
cord-285091-2i2v5ecg	99	24	intracellular	intracellular	JJ
cord-285091-2i2v5ecg	99	25	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	99	26	L	l	NN
cord-285091-2i2v5ecg	99	27	activity	activity	NN
cord-285091-2i2v5ecg	99	28	,	,	,
cord-285091-2i2v5ecg	99	29	despite	despite	IN
cord-285091-2i2v5ecg	99	30	the	the	DT
cord-285091-2i2v5ecg	99	31	persistence	persistence	NN
cord-285091-2i2v5ecg	99	32	of	of	IN
cord-285091-2i2v5ecg	99	33	high	high	JJ
cord-285091-2i2v5ecg	99	34	levels	level	NNS
cord-285091-2i2v5ecg	99	35	of	of	IN
cord-285091-2i2v5ecg	99	36	mature	mature	JJ
cord-285091-2i2v5ecg	99	37	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	99	38	L	l	NN
cord-285091-2i2v5ecg	99	39	protein	protein	NN
cord-285091-2i2v5ecg	99	40	[	[	-LRB-
cord-285091-2i2v5ecg	99	41	69	69	CD
cord-285091-2i2v5ecg	99	42	]	]	-RRB-
cord-285091-2i2v5ecg	99	43	.	.	.
cord-285091-2i2v5ecg	100	1	The	the	DT
cord-285091-2i2v5ecg	100	2	reason	reason	NN
cord-285091-2i2v5ecg	100	3	for	for	IN
cord-285091-2i2v5ecg	100	4	the	the	DT
cord-285091-2i2v5ecg	100	5	lack	lack	NN
cord-285091-2i2v5ecg	100	6	of	of	IN
cord-285091-2i2v5ecg	100	7	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	100	8	L	l	NN
cord-285091-2i2v5ecg	100	9	enzyme	enzyme	NN
cord-285091-2i2v5ecg	100	10	activity	activity	NN
cord-285091-2i2v5ecg	100	11	is	be	VBZ
cord-285091-2i2v5ecg	100	12	still	still	RB
cord-285091-2i2v5ecg	100	13	not	not	RB
cord-285091-2i2v5ecg	100	14	clear	clear	JJ
cord-285091-2i2v5ecg	100	15	.	.	.
cord-285091-2i2v5ecg	101	1	Beers	Beers	NNP
cord-285091-2i2v5ecg	101	2	et	et	NNP
cord-285091-2i2v5ecg	101	3	al	al	NNP
cord-285091-2i2v5ecg	101	4	.	.	NNP
cord-285091-2i2v5ecg	101	5	showed	show	VBD
cord-285091-2i2v5ecg	101	6	that	that	IN
cord-285091-2i2v5ecg	101	7	inhibitors	inhibitor	NNS
cord-285091-2i2v5ecg	101	8	of	of	IN
cord-285091-2i2v5ecg	101	9	cysteine	cysteine	NN
cord-285091-2i2v5ecg	101	10	proteinases	proteinases	NNP
cord-285091-2i2v5ecg	101	11	cystatin	cystatin	NNP
cord-285091-2i2v5ecg	101	12	C	C	NNP
cord-285091-2i2v5ecg	101	13	and	and	CC
cord-285091-2i2v5ecg	101	14	p41	p41	NN
cord-285091-2i2v5ecg	101	15	form	form	NN
cord-285091-2i2v5ecg	101	16	of	of	IN
cord-285091-2i2v5ecg	101	17	major	major	JJ
cord-285091-2i2v5ecg	101	18	histocompatibility	histocompatibility	NN
cord-285091-2i2v5ecg	101	19	complex	complex	NN
cord-285091-2i2v5ecg	101	20	invariant	invariant	JJ
cord-285091-2i2v5ecg	101	21	chain	chain	NN
cord-285091-2i2v5ecg	101	22	did	do	VBD
cord-285091-2i2v5ecg	101	23	not	not	RB
cord-285091-2i2v5ecg	101	24	inhibit	inhibit	VB
cord-285091-2i2v5ecg	101	25	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	101	26	L	l	NN
cord-285091-2i2v5ecg	101	27	and	and	CC
cord-285091-2i2v5ecg	101	28	the	the	DT
cord-285091-2i2v5ecg	101	29	authors	author	NNS
cord-285091-2i2v5ecg	101	30	suggested	suggest	VBD
cord-285091-2i2v5ecg	101	31	that	that	IN
cord-285091-2i2v5ecg	101	32	cystatin	cystatin	NNP
cord-285091-2i2v5ecg	101	33	F	F	NNP
cord-285091-2i2v5ecg	101	34	might	may	MD
cord-285091-2i2v5ecg	101	35	be	be	VB
cord-285091-2i2v5ecg	101	36	the	the	DT
cord-285091-2i2v5ecg	101	37	inhibitor	inhibitor	NN
cord-285091-2i2v5ecg	101	38	that	that	WDT
cord-285091-2i2v5ecg	101	39	selectively	selectively	RB
cord-285091-2i2v5ecg	101	40	regulated	regulate	VBD
cord-285091-2i2v5ecg	101	41	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	101	42	L	l	NN
cord-285091-2i2v5ecg	101	43	activity	activity	NN
cord-285091-2i2v5ecg	101	44	in	in	IN
cord-285091-2i2v5ecg	101	45	macrophages	macrophage	NNS
cord-285091-2i2v5ecg	101	46	[	[	-LRB-
cord-285091-2i2v5ecg	101	47	69	69	CD
cord-285091-2i2v5ecg	101	48	]	]	-RRB-
cord-285091-2i2v5ecg	101	49	.	.	.
cord-285091-2i2v5ecg	102	1	Recently	recently	RB
cord-285091-2i2v5ecg	102	2	,	,	,
cord-285091-2i2v5ecg	102	3	Colbert	Colbert	NNP
cord-285091-2i2v5ecg	102	4	et	et	NNP
cord-285091-2i2v5ecg	102	5	al	al	NNP
cord-285091-2i2v5ecg	102	6	.	.	NNP
cord-285091-2i2v5ecg	102	7	found	find	VBD
cord-285091-2i2v5ecg	102	8	equivalent	equivalent	JJ
cord-285091-2i2v5ecg	102	9	loss	loss	NN
cord-285091-2i2v5ecg	102	10	of	of	IN
cord-285091-2i2v5ecg	102	11	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	102	12	L	l	NN
cord-285091-2i2v5ecg	102	13	activity	activity	NN
cord-285091-2i2v5ecg	102	14	in	in	IN
cord-285091-2i2v5ecg	102	15	IFN	IFN	NNP
cord-285091-2i2v5ecg	102	16	-	-	HYPH
cord-285091-2i2v5ecg	102	17	stimulated	stimulate	VBN
cord-285091-2i2v5ecg	102	18	wild	wild	JJ
cord-285091-2i2v5ecg	102	19	type	type	NN
cord-285091-2i2v5ecg	102	20	and	and	CC
cord-285091-2i2v5ecg	102	21	cystatin	cystatin	NNP
cord-285091-2i2v5ecg	102	22	F	f	NN
cord-285091-2i2v5ecg	102	23	-	-	HYPH
cord-285091-2i2v5ecg	102	24	deficient	deficient	JJ
cord-285091-2i2v5ecg	102	25	macrophages	macrophage	NNS
cord-285091-2i2v5ecg	102	26	,	,	,
cord-285091-2i2v5ecg	102	27	indicating	indicate	VBG
cord-285091-2i2v5ecg	102	28	that	that	IN
cord-285091-2i2v5ecg	102	29	cystatin	cystatin	NNP
cord-285091-2i2v5ecg	102	30	F	F	NNP
cord-285091-2i2v5ecg	102	31	did	do	VBD
cord-285091-2i2v5ecg	102	32	not	not	RB
cord-285091-2i2v5ecg	102	33	inhibit	inhibit	VB
cord-285091-2i2v5ecg	102	34	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	102	35	L	l	NN
cord-285091-2i2v5ecg	102	36	activity	activity	NN
cord-285091-2i2v5ecg	102	37	in	in	IN
cord-285091-2i2v5ecg	102	38	activated	activate	VBN
cord-285091-2i2v5ecg	102	39	macrophages	macrophage	NNS
cord-285091-2i2v5ecg	102	40	[	[	-LRB-
cord-285091-2i2v5ecg	102	41	70	70	CD
cord-285091-2i2v5ecg	102	42	]	]	-RRB-
cord-285091-2i2v5ecg	102	43	.	.	.
cord-285091-2i2v5ecg	103	1	We	-PRON-	PRP
cord-285091-2i2v5ecg	103	2	showed	show	VBD
cord-285091-2i2v5ecg	103	3	that	that	IN
cord-285091-2i2v5ecg	103	4	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	103	5	L	l	NN
cord-285091-2i2v5ecg	103	6	is	be	VBZ
cord-285091-2i2v5ecg	103	7	targeted	target	VBN
cord-285091-2i2v5ecg	103	8	to	to	IN
cord-285091-2i2v5ecg	103	9	the	the	DT
cord-285091-2i2v5ecg	103	10	nucleolus	nucleolus	NN
cord-285091-2i2v5ecg	103	11	of	of	IN
cord-285091-2i2v5ecg	103	12	classically	classically	RB
cord-285091-2i2v5ecg	103	13	activated	activate	VBN
cord-285091-2i2v5ecg	103	14	(	(	-LRB-
cord-285091-2i2v5ecg	103	15	M1	M1	NNP
cord-285091-2i2v5ecg	103	16	)	)	-RRB-
cord-285091-2i2v5ecg	103	17	,	,	,
cord-285091-2i2v5ecg	103	18	but	but	CC
cord-285091-2i2v5ecg	103	19	not	not	RB
cord-285091-2i2v5ecg	103	20	un	un	NNP
cord-285091-2i2v5ecg	103	21	-	-	HYPH
cord-285091-2i2v5ecg	103	22	stimulated	stimulate	VBN
cord-285091-2i2v5ecg	103	23	and	and	CC
cord-285091-2i2v5ecg	103	24	alternatively	alternatively	RB
cord-285091-2i2v5ecg	103	25	activated	activate	VBN
cord-285091-2i2v5ecg	103	26	(	(	-LRB-
cord-285091-2i2v5ecg	103	27	M2	M2	NNP
cord-285091-2i2v5ecg	103	28	)	)	-RRB-
cord-285091-2i2v5ecg	103	29	macrophages	macrophage	NNS
cord-285091-2i2v5ecg	103	30	[	[	-LRB-
cord-285091-2i2v5ecg	103	31	71	71	CD
cord-285091-2i2v5ecg	103	32	]	]	-RRB-
cord-285091-2i2v5ecg	103	33	.	.	.
cord-285091-2i2v5ecg	104	1	Therefore	therefore	RB
cord-285091-2i2v5ecg	104	2	,	,	,
cord-285091-2i2v5ecg	104	3	we	-PRON-	PRP
cord-285091-2i2v5ecg	104	4	proposed	propose	VBD
cord-285091-2i2v5ecg	104	5	that	that	DT
cord-285091-2i2v5ecg	104	6	lack	lack	NN
cord-285091-2i2v5ecg	104	7	of	of	IN
cord-285091-2i2v5ecg	104	8	activity	activity	NN
cord-285091-2i2v5ecg	104	9	of	of	IN
cord-285091-2i2v5ecg	104	10	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	104	11	L	l	NN
cord-285091-2i2v5ecg	104	12	in	in	IN
cord-285091-2i2v5ecg	104	13	classically	classically	RB
cord-285091-2i2v5ecg	104	14	activated	activate	VBN
cord-285091-2i2v5ecg	104	15	macrophages	macrophage	NNS
cord-285091-2i2v5ecg	104	16	could	could	MD
cord-285091-2i2v5ecg	104	17	be	be	VB
cord-285091-2i2v5ecg	104	18	,	,	,
cord-285091-2i2v5ecg	104	19	at	at	IN
cord-285091-2i2v5ecg	104	20	least	least	JJS
cord-285091-2i2v5ecg	104	21	in	in	IN
cord-285091-2i2v5ecg	104	22	part	part	NN
cord-285091-2i2v5ecg	104	23	,	,	,
cord-285091-2i2v5ecg	104	24	due	due	IN
cord-285091-2i2v5ecg	104	25	to	to	IN
cord-285091-2i2v5ecg	104	26	different	different	JJ
cord-285091-2i2v5ecg	104	27	nucleolar	nucleolar	JJ
cord-285091-2i2v5ecg	104	28	localization	localization	NN
cord-285091-2i2v5ecg	104	29	of	of	IN
cord-285091-2i2v5ecg	104	30	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	104	31	L	l	NN
cord-285091-2i2v5ecg	104	32	and	and	CC
cord-285091-2i2v5ecg	104	33	co	co	NN
cord-285091-2i2v5ecg	104	34	-	-	NN
cord-285091-2i2v5ecg	104	35	localization	localization	NN
cord-285091-2i2v5ecg	104	36	with	with	IN
cord-285091-2i2v5ecg	104	37	Spia3	Spia3	NNP
cord-285091-2i2v5ecg	104	38	g	g	NNP
cord-285091-2i2v5ecg	104	39	[	[	-LRB-
cord-285091-2i2v5ecg	104	40	71	71	CD
cord-285091-2i2v5ecg	104	41	]	]	-RRB-
cord-285091-2i2v5ecg	104	42	.	.	.
cord-285091-2i2v5ecg	105	1	Since	since	IN
cord-285091-2i2v5ecg	105	2	only	only	RB
cord-285091-2i2v5ecg	105	3	the	the	DT
cord-285091-2i2v5ecg	105	4	pro	pro	JJ
cord-285091-2i2v5ecg	105	5	-	-	JJ
cord-285091-2i2v5ecg	105	6	inflammatory	inflammatory	JJ
cord-285091-2i2v5ecg	105	7	stimuli	stimulus	NNS
cord-285091-2i2v5ecg	105	8	(	(	-LRB-
cord-285091-2i2v5ecg	105	9	IFN	IFN	NNP
cord-285091-2i2v5ecg	105	10	-	-	HYPH
cord-285091-2i2v5ecg	105	11	and	and	CC
cord-285091-2i2v5ecg	105	12	LPS	LPS	NNP
cord-285091-2i2v5ecg	105	13	)	)	-RRB-
cord-285091-2i2v5ecg	105	14	and	and	CC
cord-285091-2i2v5ecg	105	15	not	not	RB
cord-285091-2i2v5ecg	105	16	the	the	DT
cord-285091-2i2v5ecg	105	17	anti	anti	JJ
cord-285091-2i2v5ecg	105	18	-	-	JJ
cord-285091-2i2v5ecg	105	19	inflammatory	inflammatory	JJ
cord-285091-2i2v5ecg	105	20	stimuli	stimulus	NNS
cord-285091-2i2v5ecg	105	21	(	(	-LRB-
cord-285091-2i2v5ecg	105	22	IL-4	IL-4	NNP
cord-285091-2i2v5ecg	105	23	)	)	-RRB-
cord-285091-2i2v5ecg	105	24	induce	induce	VB
cord-285091-2i2v5ecg	105	25	increased	increase	VBN
cord-285091-2i2v5ecg	105	26	nucleolar	nucleolar	JJ
cord-285091-2i2v5ecg	105	27	localization	localization	NN
cord-285091-2i2v5ecg	105	28	of	of	IN
cord-285091-2i2v5ecg	105	29	Spia3	Spia3	NNP
cord-285091-2i2v5ecg	105	30	g	g	NNP
cord-285091-2i2v5ecg	105	31	,	,	,
cord-285091-2i2v5ecg	105	32	it	-PRON-	PRP
cord-285091-2i2v5ecg	105	33	is	be	VBZ
cord-285091-2i2v5ecg	105	34	possible	possible	JJ
cord-285091-2i2v5ecg	105	35	that	that	IN
cord-285091-2i2v5ecg	105	36	Spia3	Spia3	NNP
cord-285091-2i2v5ecg	105	37	g	g	NN
cord-285091-2i2v5ecg	105	38	functions	function	NNS
cord-285091-2i2v5ecg	105	39	in	in	IN
cord-285091-2i2v5ecg	105	40	the	the	DT
cord-285091-2i2v5ecg	105	41	nucleolus	nucleolus	NN
cord-285091-2i2v5ecg	105	42	are	be	VBP
cord-285091-2i2v5ecg	105	43	important	important	JJ
cord-285091-2i2v5ecg	105	44	for	for	IN
cord-285091-2i2v5ecg	105	45	the	the	DT
cord-285091-2i2v5ecg	105	46	host	host	NN
cord-285091-2i2v5ecg	105	47	defense	defense	NN
cord-285091-2i2v5ecg	105	48	against	against	IN
cord-285091-2i2v5ecg	105	49	pathogens	pathogen	NNS
cord-285091-2i2v5ecg	105	50	.	.	.
cord-285091-2i2v5ecg	106	1	Spia3	Spia3	NNP
cord-285091-2i2v5ecg	107	1	g	g	NNP
cord-285091-2i2v5ecg	107	2	is	be	VBZ
cord-285091-2i2v5ecg	107	3	a	a	DT
cord-285091-2i2v5ecg	107	4	mouse	mouse	NN
cord-285091-2i2v5ecg	107	5	specific	specific	JJ
cord-285091-2i2v5ecg	107	6	serpin	serpin	NN
cord-285091-2i2v5ecg	107	7	and	and	CC
cord-285091-2i2v5ecg	107	8	a	a	DT
cord-285091-2i2v5ecg	107	9	human	human	JJ
cord-285091-2i2v5ecg	107	10	homologue	homologue	NN
cord-285091-2i2v5ecg	107	11	has	have	VBZ
cord-285091-2i2v5ecg	107	12	not	not	RB
cord-285091-2i2v5ecg	107	13	been	be	VBN
cord-285091-2i2v5ecg	107	14	described	describe	VBN
cord-285091-2i2v5ecg	107	15	so	so	RB
cord-285091-2i2v5ecg	107	16	far	far	RB
cord-285091-2i2v5ecg	107	17	,	,	,
cord-285091-2i2v5ecg	107	18	therefore	therefore	RB
cord-285091-2i2v5ecg	107	19	it	-PRON-	PRP
cord-285091-2i2v5ecg	107	20	is	be	VBZ
cord-285091-2i2v5ecg	107	21	not	not	RB
cord-285091-2i2v5ecg	107	22	clear	clear	JJ
cord-285091-2i2v5ecg	107	23	which	which	WDT
cord-285091-2i2v5ecg	107	24	protein	protein	NN
cord-285091-2i2v5ecg	107	25	compensates	compensate	VBZ
cord-285091-2i2v5ecg	107	26	for	for	IN
cord-285091-2i2v5ecg	107	27	Spia3	Spia3	NNP
cord-285091-2i2v5ecg	107	28	g	g	NNP
cord-285091-2i2v5ecg	107	29	deficiency	deficiency	NN
cord-285091-2i2v5ecg	107	30	in	in	IN
cord-285091-2i2v5ecg	107	31	human	human	JJ
cord-285091-2i2v5ecg	107	32	macrophages	macrophage	NNS
cord-285091-2i2v5ecg	107	33	.	.	.
cord-285091-2i2v5ecg	108	1	Inflammasomes	Inflammasomes	NNP
cord-285091-2i2v5ecg	108	2	are	be	VBP
cord-285091-2i2v5ecg	108	3	multiprotein	multiprotein	NNP
cord-285091-2i2v5ecg	108	4	complexes	complex	NNS
cord-285091-2i2v5ecg	108	5	that	that	WDT
cord-285091-2i2v5ecg	108	6	activate	activate	VBP
cord-285091-2i2v5ecg	108	7	caspase-1	caspase-1	NNP
cord-285091-2i2v5ecg	108	8	,	,	,
cord-285091-2i2v5ecg	108	9	an	an	DT
cord-285091-2i2v5ecg	108	10	event	event	NN
cord-285091-2i2v5ecg	108	11	which	which	WDT
cord-285091-2i2v5ecg	108	12	leads	lead	VBZ
cord-285091-2i2v5ecg	108	13	to	to	IN
cord-285091-2i2v5ecg	108	14	maturation	maturation	NN
cord-285091-2i2v5ecg	108	15	of	of	IN
cord-285091-2i2v5ecg	108	16	the	the	DT
cord-285091-2i2v5ecg	108	17	proinflammatory	proinflammatory	JJ
cord-285091-2i2v5ecg	108	18	cytokines	cytokine	NNS
cord-285091-2i2v5ecg	108	19	interleukin	interleukin	NN
cord-285091-2i2v5ecg	108	20	1	1	CD
cord-285091-2i2v5ecg	108	21	(	(	-LRB-
cord-285091-2i2v5ecg	108	22	IL-1	IL-1	NNP
cord-285091-2i2v5ecg	108	23	)	)	-RRB-
cord-285091-2i2v5ecg	108	24	and	and	CC
cord-285091-2i2v5ecg	108	25	IL-18	IL-18	NNP
cord-285091-2i2v5ecg	108	26	[	[	-LRB-
cord-285091-2i2v5ecg	108	27	72	72	CD
cord-285091-2i2v5ecg	108	28	]	]	-RRB-
cord-285091-2i2v5ecg	108	29	.	.	.
cord-285091-2i2v5ecg	109	1	Cytosolic	Cytosolic	NNP
cord-285091-2i2v5ecg	109	2	NLR	NLR	NNP
cord-285091-2i2v5ecg	110	1	(	(	-LRB-
cord-285091-2i2v5ecg	110	2	NLRP1	NLRP1	NNP
cord-285091-2i2v5ecg	110	3	,	,	,
cord-285091-2i2v5ecg	110	4	NLRP2	NLRP2	NNP
cord-285091-2i2v5ecg	110	5	,	,	,
cord-285091-2i2v5ecg	110	6	and	and	CC
cord-285091-2i2v5ecg	110	7	NLRP3	nlrp3	NN
cord-285091-2i2v5ecg	110	8	)	)	-RRB-
cord-285091-2i2v5ecg	110	9	are	be	VBP
cord-285091-2i2v5ecg	110	10	involved	involve	VBN
cord-285091-2i2v5ecg	110	11	in	in	IN
cord-285091-2i2v5ecg	110	12	assembly	assembly	NN
cord-285091-2i2v5ecg	110	13	of	of	IN
cord-285091-2i2v5ecg	110	14	inflammasome	inflammasome	NNP
cord-285091-2i2v5ecg	110	15	and	and	CC
cord-285091-2i2v5ecg	110	16	the	the	DT
cord-285091-2i2v5ecg	110	17	NLRP3	nlrp3	NN
cord-285091-2i2v5ecg	110	18	can	can	MD
cord-285091-2i2v5ecg	110	19	be	be	VB
cord-285091-2i2v5ecg	110	20	activated	activate	VBN
cord-285091-2i2v5ecg	110	21	not	not	RB
cord-285091-2i2v5ecg	110	22	only	only	RB
cord-285091-2i2v5ecg	110	23	by	by	IN
cord-285091-2i2v5ecg	110	24	bacteria	bacteria	NNS
cord-285091-2i2v5ecg	110	25	,	,	,
cord-285091-2i2v5ecg	110	26	bacterial	bacterial	JJ
cord-285091-2i2v5ecg	110	27	pore	pore	NN
cord-285091-2i2v5ecg	110	28	forming	form	VBG
cord-285091-2i2v5ecg	110	29	toxins	toxin	NNS
cord-285091-2i2v5ecg	110	30	or	or	CC
cord-285091-2i2v5ecg	110	31	viruses	virus	NNS
cord-285091-2i2v5ecg	110	32	[	[	-LRB-
cord-285091-2i2v5ecg	110	33	73	73	CD
cord-285091-2i2v5ecg	110	34	]	]	-RRB-
cord-285091-2i2v5ecg	110	35	,	,	,
cord-285091-2i2v5ecg	110	36	but	but	CC
cord-285091-2i2v5ecg	110	37	also	also	RB
cord-285091-2i2v5ecg	110	38	by	by	IN
cord-285091-2i2v5ecg	110	39	a	a	DT
cord-285091-2i2v5ecg	110	40	number	number	NN
cord-285091-2i2v5ecg	110	41	of	of	IN
cord-285091-2i2v5ecg	110	42	molecules	molecule	NNS
cord-285091-2i2v5ecg	110	43	like	like	IN
cord-285091-2i2v5ecg	110	44	crystals	crystal	NNS
cord-285091-2i2v5ecg	110	45	silica	silica	NN
cord-285091-2i2v5ecg	110	46	,	,	,
cord-285091-2i2v5ecg	110	47	asbestos	asbestos	NN
cord-285091-2i2v5ecg	110	48	,	,	,
cord-285091-2i2v5ecg	110	49	alum	alum	NN
cord-285091-2i2v5ecg	110	50	and	and	CC
cord-285091-2i2v5ecg	110	51	-amyloid	-amyloid	JJ
cord-285091-2i2v5ecg	110	52	[	[	-LRB-
cord-285091-2i2v5ecg	110	53	74	74	CD
cord-285091-2i2v5ecg	110	54	]	]	-RRB-
cord-285091-2i2v5ecg	110	55	[	[	-LRB-
cord-285091-2i2v5ecg	110	56	75	75	CD
cord-285091-2i2v5ecg	110	57	]	]	-RRB-
cord-285091-2i2v5ecg	110	58	[	[	-LRB-
cord-285091-2i2v5ecg	110	59	76	76	CD
cord-285091-2i2v5ecg	110	60	]	]	-RRB-
cord-285091-2i2v5ecg	110	61	[	[	-LRB-
cord-285091-2i2v5ecg	110	62	77	77	CD
cord-285091-2i2v5ecg	110	63	]	]	-RRB-
cord-285091-2i2v5ecg	110	64	[	[	-LRB-
cord-285091-2i2v5ecg	110	65	78	78	CD
cord-285091-2i2v5ecg	110	66	]	]	-RRB-
cord-285091-2i2v5ecg	110	67	.	.	.
cord-285091-2i2v5ecg	111	1	It	-PRON-	PRP
cord-285091-2i2v5ecg	111	2	was	be	VBD
cord-285091-2i2v5ecg	111	3	shown	show	VBN
cord-285091-2i2v5ecg	111	4	that	that	DT
cord-285091-2i2v5ecg	111	5	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	111	6	B	b	NN
cord-285091-2i2v5ecg	111	7	(	(	-LRB-
cord-285091-2i2v5ecg	111	8	and	and	CC
cord-285091-2i2v5ecg	111	9	possibly	possibly	RB
cord-285091-2i2v5ecg	111	10	other	other	JJ
cord-285091-2i2v5ecg	111	11	cathepsins	cathepsin	NNS
cord-285091-2i2v5ecg	111	12	)	)	-RRB-
cord-285091-2i2v5ecg	111	13	leaking	leak	VBG
cord-285091-2i2v5ecg	111	14	from	from	IN
cord-285091-2i2v5ecg	111	15	the	the	DT
cord-285091-2i2v5ecg	111	16	lysosomes	lysosome	NNS
cord-285091-2i2v5ecg	111	17	had	have	VBD
cord-285091-2i2v5ecg	111	18	an	an	DT
cord-285091-2i2v5ecg	111	19	important	important	JJ
cord-285091-2i2v5ecg	111	20	role	role	NN
cord-285091-2i2v5ecg	111	21	in	in	IN
cord-285091-2i2v5ecg	111	22	a	a	DT
cord-285091-2i2v5ecg	111	23	direct	direct	JJ
cord-285091-2i2v5ecg	111	24	NLRP3	nlrp3	NN
cord-285091-2i2v5ecg	111	25	activation	activation	NN
cord-285091-2i2v5ecg	111	26	by	by	IN
cord-285091-2i2v5ecg	111	27	crystals	crystal	NNS
cord-285091-2i2v5ecg	111	28	and	and	CC
cord-285091-2i2v5ecg	111	29	-amyloid	-amyloid	NFP
cord-285091-2i2v5ecg	111	30	[	[	-LRB-
cord-285091-2i2v5ecg	111	31	74	74	CD
cord-285091-2i2v5ecg	111	32	,	,	,
cord-285091-2i2v5ecg	111	33	75	75	CD
cord-285091-2i2v5ecg	111	34	]	]	-RRB-
cord-285091-2i2v5ecg	111	35	.	.	.
cord-285091-2i2v5ecg	112	1	In	in	IN
cord-285091-2i2v5ecg	112	2	addition	addition	NN
cord-285091-2i2v5ecg	112	3	,	,	,
cord-285091-2i2v5ecg	112	4	it	-PRON-	PRP
cord-285091-2i2v5ecg	112	5	was	be	VBD
cord-285091-2i2v5ecg	112	6	reported	report	VBN
cord-285091-2i2v5ecg	112	7	that	that	IN
cord-285091-2i2v5ecg	112	8	live	live	VBP
cord-285091-2i2v5ecg	112	9	intracellular	intracellular	JJ
cord-285091-2i2v5ecg	112	10	mycobacterium	mycobacterium	NN
cord-285091-2i2v5ecg	112	11	M.	M.	NNP
cord-285091-2i2v5ecg	112	12	kansasii	kansasii	NNS
cord-285091-2i2v5ecg	112	13	triggered	trigger	VBD
cord-285091-2i2v5ecg	112	14	the	the	DT
cord-285091-2i2v5ecg	112	15	activation	activation	NN
cord-285091-2i2v5ecg	112	16	of	of	IN
cord-285091-2i2v5ecg	112	17	the	the	DT
cord-285091-2i2v5ecg	112	18	NLRP3	NLRP3	NNP
cord-285091-2i2v5ecg	112	19	inflammasome	inflammasome	NNP
cord-285091-2i2v5ecg	112	20	and	and	CC
cord-285091-2i2v5ecg	112	21	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	112	22	B	B	NNP
cord-285091-2i2v5ecg	112	23	release	release	NN
cord-285091-2i2v5ecg	112	24	from	from	IN
cord-285091-2i2v5ecg	112	25	the	the	DT
cord-285091-2i2v5ecg	112	26	endosomes	endosome	NNS
cord-285091-2i2v5ecg	112	27	and	and	CC
cord-285091-2i2v5ecg	112	28	that	that	IN
cord-285091-2i2v5ecg	112	29	the	the	DT
cord-285091-2i2v5ecg	112	30	production	production	NN
cord-285091-2i2v5ecg	112	31	of	of	IN
cord-285091-2i2v5ecg	112	32	reactive	reactive	JJ
cord-285091-2i2v5ecg	112	33	oxygen	oxygen	NN
cord-285091-2i2v5ecg	112	34	species	specie	NNS
cord-285091-2i2v5ecg	112	35	was	be	VBD
cord-285091-2i2v5ecg	112	36	essential	essential	JJ
cord-285091-2i2v5ecg	112	37	in	in	IN
cord-285091-2i2v5ecg	112	38	this	this	DT
cord-285091-2i2v5ecg	112	39	process	process	NN
cord-285091-2i2v5ecg	112	40	[	[	-LRB-
cord-285091-2i2v5ecg	112	41	79	79	CD
cord-285091-2i2v5ecg	112	42	]	]	-RRB-
cord-285091-2i2v5ecg	112	43	.	.	.
cord-285091-2i2v5ecg	113	1	Therefore	therefore	RB
cord-285091-2i2v5ecg	113	2	cysteine	cysteine	NN
cord-285091-2i2v5ecg	113	3	cathepins	cathepin	NNS
cord-285091-2i2v5ecg	113	4	participate	participate	VBP
cord-285091-2i2v5ecg	113	5	in	in	IN
cord-285091-2i2v5ecg	113	6	the	the	DT
cord-285091-2i2v5ecg	113	7	defense	defense	NN
cord-285091-2i2v5ecg	113	8	against	against	IN
cord-285091-2i2v5ecg	113	9	pathogens	pathogen	NNS
cord-285091-2i2v5ecg	113	10	in	in	IN
cord-285091-2i2v5ecg	113	11	cytosol	cytosol	NN
cord-285091-2i2v5ecg	113	12	.	.	.
cord-285091-2i2v5ecg	114	1	The	the	DT
cord-285091-2i2v5ecg	114	2	cytosolic	cytosolic	JJ
cord-285091-2i2v5ecg	114	3	cysteine	cysteine	NN
cord-285091-2i2v5ecg	114	4	proteinase	proteinase	NN
cord-285091-2i2v5ecg	114	5	inhibitors	inhibitor	NNS
cord-285091-2i2v5ecg	114	6	could	could	MD
cord-285091-2i2v5ecg	114	7	regulate	regulate	VB
cord-285091-2i2v5ecg	114	8	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	114	9	activity	activity	NN
cord-285091-2i2v5ecg	114	10	in	in	IN
cord-285091-2i2v5ecg	114	11	this	this	DT
cord-285091-2i2v5ecg	114	12	process	process	NN
cord-285091-2i2v5ecg	114	13	and	and	CC
cord-285091-2i2v5ecg	114	14	prevent	prevent	VB
cord-285091-2i2v5ecg	114	15	excessive	excessive	JJ
cord-285091-2i2v5ecg	114	16	inflammation	inflammation	NN
cord-285091-2i2v5ecg	114	17	.	.	.
cord-285091-2i2v5ecg	115	1	DCs	DCs	NNP
cord-285091-2i2v5ecg	115	2	are	be	VBP
cord-285091-2i2v5ecg	115	3	antigen	antigen	NN
cord-285091-2i2v5ecg	115	4	presenting	present	VBG
cord-285091-2i2v5ecg	115	5	cells	cell	NNS
cord-285091-2i2v5ecg	115	6	characterized	characterize	VBN
cord-285091-2i2v5ecg	115	7	by	by	IN
cord-285091-2i2v5ecg	115	8	their	-PRON-	PRP$
cord-285091-2i2v5ecg	115	9	efficient	efficient	JJ
cord-285091-2i2v5ecg	115	10	processing	processing	NN
cord-285091-2i2v5ecg	115	11	of	of	IN
cord-285091-2i2v5ecg	115	12	internalized	internalize	VBN
cord-285091-2i2v5ecg	115	13	antigens	antigen	NNS
cord-285091-2i2v5ecg	115	14	and	and	CC
cord-285091-2i2v5ecg	115	15	the	the	DT
cord-285091-2i2v5ecg	115	16	presentation	presentation	NN
cord-285091-2i2v5ecg	115	17	of	of	IN
cord-285091-2i2v5ecg	115	18	peptide	peptide	NN
cord-285091-2i2v5ecg	115	19	bound	bind	VBN
cord-285091-2i2v5ecg	115	20	to	to	IN
cord-285091-2i2v5ecg	115	21	major	major	JJ
cord-285091-2i2v5ecg	115	22	histocompatibility	histocompatibility	NN
cord-285091-2i2v5ecg	115	23	(	(	-LRB-
cord-285091-2i2v5ecg	115	24	MHC	MHC	NNP
cord-285091-2i2v5ecg	115	25	)	)	-RRB-
cord-285091-2i2v5ecg	115	26	complexes	complex	NNS
cord-285091-2i2v5ecg	115	27	to	to	IN
cord-285091-2i2v5ecg	115	28	the	the	DT
cord-285091-2i2v5ecg	115	29	T	t	NN
cord-285091-2i2v5ecg	115	30	cells	cell	NNS
cord-285091-2i2v5ecg	115	31	[	[	-LRB-
cord-285091-2i2v5ecg	115	32	80	80	CD
cord-285091-2i2v5ecg	115	33	,	,	,
cord-285091-2i2v5ecg	115	34	81	81	CD
cord-285091-2i2v5ecg	115	35	]	]	-RRB-
cord-285091-2i2v5ecg	115	36	.	.	.
cord-285091-2i2v5ecg	116	1	Immature	immature	JJ
cord-285091-2i2v5ecg	116	2	DCs	dc	NNS
cord-285091-2i2v5ecg	116	3	reside	reside	VBP
cord-285091-2i2v5ecg	116	4	in	in	IN
cord-285091-2i2v5ecg	116	5	tissues	tissue	NNS
cord-285091-2i2v5ecg	116	6	and	and	CC
cord-285091-2i2v5ecg	116	7	actively	actively	RB
cord-285091-2i2v5ecg	116	8	uptake	uptake	NN
cord-285091-2i2v5ecg	116	9	antigens	antigen	NNS
cord-285091-2i2v5ecg	116	10	.	.	.
cord-285091-2i2v5ecg	117	1	Maturation	maturation	NN
cord-285091-2i2v5ecg	117	2	of	of	IN
cord-285091-2i2v5ecg	117	3	DCs	dc	NNS
cord-285091-2i2v5ecg	117	4	can	can	MD
cord-285091-2i2v5ecg	117	5	be	be	VB
cord-285091-2i2v5ecg	117	6	achieved	achieve	VBN
cord-285091-2i2v5ecg	117	7	by	by	IN
cord-285091-2i2v5ecg	117	8	TLRs	tlr	NNS
cord-285091-2i2v5ecg	117	9	[	[	-LRB-
cord-285091-2i2v5ecg	117	10	82	82	CD
cord-285091-2i2v5ecg	117	11	]	]	-RRB-
cord-285091-2i2v5ecg	118	1	[	[	-LRB-
cord-285091-2i2v5ecg	118	2	83	83	CD
cord-285091-2i2v5ecg	118	3	]	]	-RRB-
cord-285091-2i2v5ecg	118	4	[	[	-LRB-
cord-285091-2i2v5ecg	118	5	84	84	CD
cord-285091-2i2v5ecg	118	6	]	]	-RRB-
cord-285091-2i2v5ecg	118	7	.	.	.
cord-285091-2i2v5ecg	119	1	The	the	DT
cord-285091-2i2v5ecg	119	2	expression	expression	NN
cord-285091-2i2v5ecg	119	3	of	of	IN
cord-285091-2i2v5ecg	119	4	a	a	DT
cord-285091-2i2v5ecg	119	5	unique	unique	JJ
cord-285091-2i2v5ecg	119	6	set	set	NN
cord-285091-2i2v5ecg	119	7	of	of	IN
cord-285091-2i2v5ecg	119	8	TLRs	tlr	NNS
cord-285091-2i2v5ecg	119	9	renders	render	VBZ
cord-285091-2i2v5ecg	119	10	each	each	DT
cord-285091-2i2v5ecg	119	11	type	type	NN
cord-285091-2i2v5ecg	119	12	of	of	IN
cord-285091-2i2v5ecg	119	13	DC	DC	NNP
cord-285091-2i2v5ecg	119	14	susceptible	susceptible	JJ
cord-285091-2i2v5ecg	119	15	to	to	IN
cord-285091-2i2v5ecg	119	16	particular	particular	JJ
cord-285091-2i2v5ecg	119	17	subsets	subset	NNS
cord-285091-2i2v5ecg	119	18	of	of	IN
cord-285091-2i2v5ecg	119	19	pathogens	pathogen	NNS
cord-285091-2i2v5ecg	119	20	and	and	CC
cord-285091-2i2v5ecg	119	21	the	the	DT
cord-285091-2i2v5ecg	119	22	outcome	outcome	NN
cord-285091-2i2v5ecg	119	23	of	of	IN
cord-285091-2i2v5ecg	119	24	stimulation	stimulation	NN
cord-285091-2i2v5ecg	119	25	with	with	IN
cord-285091-2i2v5ecg	119	26	TLR	TLR	NNP
cord-285091-2i2v5ecg	119	27	ligands	ligand	NNS
cord-285091-2i2v5ecg	119	28	can	can	MD
cord-285091-2i2v5ecg	119	29	result	result	VB
cord-285091-2i2v5ecg	119	30	in	in	IN
cord-285091-2i2v5ecg	119	31	increased	increase	VBN
cord-285091-2i2v5ecg	119	32	antigen	antigen	NN
cord-285091-2i2v5ecg	119	33	uptake	uptake	NN
cord-285091-2i2v5ecg	119	34	and	and	CC
cord-285091-2i2v5ecg	119	35	presentation	presentation	NN
cord-285091-2i2v5ecg	119	36	[	[	-LRB-
cord-285091-2i2v5ecg	119	37	85	85	CD
cord-285091-2i2v5ecg	119	38	]	]	-RRB-
cord-285091-2i2v5ecg	119	39	.	.	.
cord-285091-2i2v5ecg	120	1	The	the	DT
cord-285091-2i2v5ecg	120	2	population	population	NN
cord-285091-2i2v5ecg	120	3	of	of	IN
cord-285091-2i2v5ecg	120	4	DCs	DCs	NNP
cord-285091-2i2v5ecg	120	5	can	can	MD
cord-285091-2i2v5ecg	120	6	be	be	VB
cord-285091-2i2v5ecg	120	7	divided	divide	VBN
cord-285091-2i2v5ecg	120	8	into	into	IN
cord-285091-2i2v5ecg	120	9	2	2	CD
cord-285091-2i2v5ecg	120	10	major	major	JJ
cord-285091-2i2v5ecg	120	11	sub	sub	NN
cord-285091-2i2v5ecg	120	12	populations	population	NNS
cord-285091-2i2v5ecg	120	13	:	:	:
cord-285091-2i2v5ecg	120	14	conventional	conventional	JJ
cord-285091-2i2v5ecg	120	15	DCs	dc	NNS
cord-285091-2i2v5ecg	120	16	(	(	-LRB-
cord-285091-2i2v5ecg	120	17	cDCs	cDCs	NNP
cord-285091-2i2v5ecg	120	18	)	)	-RRB-
cord-285091-2i2v5ecg	120	19	and	and	CC
cord-285091-2i2v5ecg	120	20	plasmacytoid	plasmacytoid	NNP
cord-285091-2i2v5ecg	120	21	DCs	DCs	NNP
cord-285091-2i2v5ecg	120	22	(	(	-LRB-
cord-285091-2i2v5ecg	120	23	pDCs	pDCs	NNP
cord-285091-2i2v5ecg	120	24	)	)	-RRB-
cord-285091-2i2v5ecg	120	25	[	[	-LRB-
cord-285091-2i2v5ecg	120	26	86	86	CD
cord-285091-2i2v5ecg	120	27	]	]	-RRB-
cord-285091-2i2v5ecg	120	28	.	.	.
cord-285091-2i2v5ecg	121	1	While	while	IN
cord-285091-2i2v5ecg	121	2	the	the	DT
cord-285091-2i2v5ecg	121	3	macrophages	macrophage	NNS
cord-285091-2i2v5ecg	121	4	contain	contain	VBP
cord-285091-2i2v5ecg	121	5	high	high	JJ
cord-285091-2i2v5ecg	121	6	levels	level	NNS
cord-285091-2i2v5ecg	121	7	of	of	IN
cord-285091-2i2v5ecg	121	8	endolysosomal	endolysosomal	JJ
cord-285091-2i2v5ecg	121	9	proteases	protease	NNS
cord-285091-2i2v5ecg	121	10	and	and	CC
cord-285091-2i2v5ecg	121	11	rapidly	rapidly	RB
cord-285091-2i2v5ecg	121	12	degrade	degrade	VB
cord-285091-2i2v5ecg	121	13	internalized	internalize	VBN
cord-285091-2i2v5ecg	121	14	antigens	antigen	NNS
cord-285091-2i2v5ecg	121	15	,	,	,
cord-285091-2i2v5ecg	121	16	cDCs	cDCs	''
cord-285091-2i2v5ecg	122	1	express	express	VB
cord-285091-2i2v5ecg	122	2	low	low	JJ
cord-285091-2i2v5ecg	122	3	levels	level	NNS
cord-285091-2i2v5ecg	122	4	of	of	IN
cord-285091-2i2v5ecg	122	5	endolysosmal	endolysosmal	JJ
cord-285091-2i2v5ecg	122	6	proteases	protease	NNS
cord-285091-2i2v5ecg	122	7	and	and	CC
cord-285091-2i2v5ecg	122	8	in	in	IN
cord-285091-2i2v5ecg	122	9	vivo	vivo	NN
cord-285091-2i2v5ecg	122	10	degrade	degrade	VB
cord-285091-2i2v5ecg	122	11	internalized	internalize	VBN
cord-285091-2i2v5ecg	122	12	antigens	antigen	NNS
cord-285091-2i2v5ecg	122	13	slowly	slowly	RB
cord-285091-2i2v5ecg	122	14	.	.	.
cord-285091-2i2v5ecg	123	1	However	however	RB
cord-285091-2i2v5ecg	123	2	,	,	,
cord-285091-2i2v5ecg	123	3	the	the	DT
cord-285091-2i2v5ecg	123	4	resulting	result	VBG
cord-285091-2i2v5ecg	123	5	limited	limited	JJ
cord-285091-2i2v5ecg	123	6	lysosomal	lysosomal	JJ
cord-285091-2i2v5ecg	123	7	proteolysis	proteolysis	NN
cord-285091-2i2v5ecg	123	8	in	in	IN
cord-285091-2i2v5ecg	123	9	cDCs	cDCs	NNP
cord-285091-2i2v5ecg	123	10	is	be	VBZ
cord-285091-2i2v5ecg	123	11	favourable	favourable	JJ
cord-285091-2i2v5ecg	123	12	to	to	IN
cord-285091-2i2v5ecg	123	13	the	the	DT
cord-285091-2i2v5ecg	123	14	antigen	antigen	NN
cord-285091-2i2v5ecg	123	15	presentation	presentation	NN
cord-285091-2i2v5ecg	123	16	[	[	-LRB-
cord-285091-2i2v5ecg	123	17	87	87	CD
cord-285091-2i2v5ecg	123	18	]	]	-RRB-
cord-285091-2i2v5ecg	123	19	.	.	.
cord-285091-2i2v5ecg	124	1	Subtle	subtle	JJ
cord-285091-2i2v5ecg	124	2	differences	difference	NNS
cord-285091-2i2v5ecg	124	3	exist	exist	VBP
cord-285091-2i2v5ecg	124	4	also	also	RB
cord-285091-2i2v5ecg	124	5	among	among	IN
cord-285091-2i2v5ecg	124	6	cDC	cDC	NNS
cord-285091-2i2v5ecg	124	7	;	;	:
cord-285091-2i2v5ecg	124	8	only	only	RB
cord-285091-2i2v5ecg	124	9	cDCs	cdcs	XX
cord-285091-2i2v5ecg	124	10	isolated	isolate	VBN
cord-285091-2i2v5ecg	124	11	from	from	IN
cord-285091-2i2v5ecg	124	12	peripheral	peripheral	JJ
cord-285091-2i2v5ecg	124	13	blood	blood	NN
cord-285091-2i2v5ecg	124	14	or	or	CC
cord-285091-2i2v5ecg	124	15	derived	derive	VBN
cord-285091-2i2v5ecg	124	16	in	in	IN
cord-285091-2i2v5ecg	124	17	vitro	vitro	FW
cord-285091-2i2v5ecg	124	18	from	from	IN
cord-285091-2i2v5ecg	124	19	CD34	CD34	NNP
cord-285091-2i2v5ecg	124	20	+	+	CC
cord-285091-2i2v5ecg	124	21	hematopoietic	hematopoietic	JJ
cord-285091-2i2v5ecg	124	22	progenitor	progenitor	NN
cord-285091-2i2v5ecg	124	23	cells	cell	NNS
cord-285091-2i2v5ecg	124	24	are	be	VBP
cord-285091-2i2v5ecg	124	25	protease	protease	NN
cord-285091-2i2v5ecg	124	26	poor	poor	JJ
cord-285091-2i2v5ecg	124	27	,	,	,
cord-285091-2i2v5ecg	124	28	whereas	whereas	IN
cord-285091-2i2v5ecg	124	29	cDCs	cdcs	RB
cord-285091-2i2v5ecg	124	30	differentiated	differentiate	VBN
cord-285091-2i2v5ecg	124	31	in	in	IN
cord-285091-2i2v5ecg	124	32	vitro	vitro	FW
cord-285091-2i2v5ecg	124	33	from	from	IN
cord-285091-2i2v5ecg	124	34	monocytes	monocyte	NNS
cord-285091-2i2v5ecg	124	35	exhibit	exhibit	NN
cord-285091-2i2v5ecg	124	36	protease	protease	JJ
cord-285091-2i2v5ecg	124	37	expression	expression	NN
cord-285091-2i2v5ecg	124	38	and	and	CC
cord-285091-2i2v5ecg	124	39	activity	activity	NN
cord-285091-2i2v5ecg	124	40	similar	similar	JJ
cord-285091-2i2v5ecg	124	41	to	to	IN
cord-285091-2i2v5ecg	124	42	macrophages	macrophage	NNS
cord-285091-2i2v5ecg	124	43	[	[	-LRB-
cord-285091-2i2v5ecg	124	44	88	88	CD
cord-285091-2i2v5ecg	124	45	]	]	-RRB-
cord-285091-2i2v5ecg	124	46	.	.	.
cord-285091-2i2v5ecg	125	1	T	T	NNP
cord-285091-2i2v5ecg	125	2	lymphocytes	lymphocyte	NNS
cord-285091-2i2v5ecg	125	3	recognize	recognize	VBP
cord-285091-2i2v5ecg	125	4	proteolytic	proteolytic	JJ
cord-285091-2i2v5ecg	125	5	fragments	fragment	NNS
cord-285091-2i2v5ecg	125	6	of	of	IN
cord-285091-2i2v5ecg	125	7	antigens	antigen	NNS
cord-285091-2i2v5ecg	125	8	that	that	WDT
cord-285091-2i2v5ecg	125	9	are	be	VBP
cord-285091-2i2v5ecg	125	10	presented	present	VBN
cord-285091-2i2v5ecg	125	11	to	to	IN
cord-285091-2i2v5ecg	125	12	them	-PRON-	PRP
cord-285091-2i2v5ecg	125	13	on	on	IN
cord-285091-2i2v5ecg	125	14	MHC	MHC	NNP
cord-285091-2i2v5ecg	125	15	molecules	molecule	NNS
cord-285091-2i2v5ecg	125	16	.	.	.
cord-285091-2i2v5ecg	126	1	MHC	MHC	NNP
cord-285091-2i2v5ecg	126	2	class	class	NN
cord-285091-2i2v5ecg	127	1	I	-PRON-	PRP
cord-285091-2i2v5ecg	127	2	molecules	molecule	NNS
cord-285091-2i2v5ecg	127	3	present	present	VBP
cord-285091-2i2v5ecg	127	4	primarily	primarily	RB
cord-285091-2i2v5ecg	127	5	products	product	NNS
cord-285091-2i2v5ecg	127	6	of	of	IN
cord-285091-2i2v5ecg	127	7	proteasomal	proteasomal	JJ
cord-285091-2i2v5ecg	127	8	proteolysis	proteolysis	NN
cord-285091-2i2v5ecg	127	9	to	to	IN
cord-285091-2i2v5ecg	127	10	CD8	CD8	NNP
cord-285091-2i2v5ecg	127	11	+	+	CC
cord-285091-2i2v5ecg	127	12	T	T	NNP
cord-285091-2i2v5ecg	127	13	cells	cell	NNS
cord-285091-2i2v5ecg	127	14	,	,	,
cord-285091-2i2v5ecg	127	15	while	while	IN
cord-285091-2i2v5ecg	127	16	MHC	MHC	NNP
cord-285091-2i2v5ecg	127	17	class	class	NN
cord-285091-2i2v5ecg	127	18	II	II	NNP
cord-285091-2i2v5ecg	127	19	molecules	molecule	NNS
cord-285091-2i2v5ecg	127	20	display	display	VBP
cord-285091-2i2v5ecg	127	21	mainly	mainly	RB
cord-285091-2i2v5ecg	127	22	degradation	degradation	NN
cord-285091-2i2v5ecg	127	23	products	product	NNS
cord-285091-2i2v5ecg	127	24	of	of	IN
cord-285091-2i2v5ecg	127	25	lysosomes	lysosome	NNS
cord-285091-2i2v5ecg	127	26	for	for	IN
cord-285091-2i2v5ecg	127	27	stimulation	stimulation	NN
cord-285091-2i2v5ecg	127	28	of	of	IN
cord-285091-2i2v5ecg	127	29	CD4	CD4	NNP
cord-285091-2i2v5ecg	127	30	+	+	CC
cord-285091-2i2v5ecg	127	31	T	t	NN
cord-285091-2i2v5ecg	127	32	cells	cell	NNS
cord-285091-2i2v5ecg	127	33	[	[	-LRB-
cord-285091-2i2v5ecg	127	34	66	66	CD
cord-285091-2i2v5ecg	127	35	]	]	-RRB-
cord-285091-2i2v5ecg	127	36	.	.	.
cord-285091-2i2v5ecg	128	1	MHC	MHC	NNP
cord-285091-2i2v5ecg	128	2	class	class	NN
cord-285091-2i2v5ecg	128	3	II	II	NNP
cord-285091-2i2v5ecg	128	4	molecules	molecule	NNS
cord-285091-2i2v5ecg	128	5	are	be	VBP
cord-285091-2i2v5ecg	128	6	assembled	assemble	VBN
cord-285091-2i2v5ecg	128	7	in	in	IN
cord-285091-2i2v5ecg	128	8	the	the	DT
cord-285091-2i2v5ecg	128	9	endoplasmic	endoplasmic	NN
cord-285091-2i2v5ecg	128	10	reticulum	reticulum	NN
cord-285091-2i2v5ecg	128	11	with	with	IN
cord-285091-2i2v5ecg	128	12	the	the	DT
cord-285091-2i2v5ecg	128	13	assistance	assistance	NN
cord-285091-2i2v5ecg	128	14	of	of	IN
cord-285091-2i2v5ecg	128	15	chaperone	chaperone	NN
cord-285091-2i2v5ecg	128	16	invariant	invariant	JJ
cord-285091-2i2v5ecg	128	17	chain	chain	NN
cord-285091-2i2v5ecg	128	18	(	(	-LRB-
cord-285091-2i2v5ecg	128	19	Ii	Ii	NNP
cord-285091-2i2v5ecg	128	20	)	)	-RRB-
cord-285091-2i2v5ecg	128	21	.	.	.
cord-285091-2i2v5ecg	129	1	A	a	DT
cord-285091-2i2v5ecg	129	2	portion	portion	NN
cord-285091-2i2v5ecg	129	3	of	of	IN
cord-285091-2i2v5ecg	129	4	Ii	Ii	NNP
cord-285091-2i2v5ecg	129	5	,	,	,
cord-285091-2i2v5ecg	129	6	termed	term	VBN
cord-285091-2i2v5ecg	129	7	CLIP	clip	NN
cord-285091-2i2v5ecg	129	8	,	,	,
cord-285091-2i2v5ecg	129	9	binds	bind	VBZ
cord-285091-2i2v5ecg	129	10	in	in	IN
cord-285091-2i2v5ecg	129	11	the	the	DT
cord-285091-2i2v5ecg	129	12	peptide	peptide	NN
cord-285091-2i2v5ecg	129	13	groove	groove	NN
cord-285091-2i2v5ecg	129	14	of	of	IN
cord-285091-2i2v5ecg	129	15	MHC	MHC	NNP
cord-285091-2i2v5ecg	129	16	class	class	NN
cord-285091-2i2v5ecg	129	17	II	II	NNP
cord-285091-2i2v5ecg	129	18	molecules	molecule	NNS
cord-285091-2i2v5ecg	129	19	,	,	,
cord-285091-2i2v5ecg	129	20	thereby	thereby	RB
cord-285091-2i2v5ecg	129	21	preventing	prevent	VBG
cord-285091-2i2v5ecg	129	22	premature	premature	JJ
cord-285091-2i2v5ecg	129	23	loading	loading	NN
cord-285091-2i2v5ecg	129	24	of	of	IN
cord-285091-2i2v5ecg	129	25	peptides	peptide	NNS
cord-285091-2i2v5ecg	129	26	[	[	-LRB-
cord-285091-2i2v5ecg	129	27	66	66	CD
cord-285091-2i2v5ecg	129	28	]	]	-RRB-
cord-285091-2i2v5ecg	129	29	.	.	.
cord-285091-2i2v5ecg	130	1	Gene	gene	NN
cord-285091-2i2v5ecg	130	2	targeting	targeting	JJ
cord-285091-2i2v5ecg	130	3	studies	study	NNS
cord-285091-2i2v5ecg	130	4	showed	show	VBD
cord-285091-2i2v5ecg	130	5	a	a	DT
cord-285091-2i2v5ecg	130	6	critical	critical	JJ
cord-285091-2i2v5ecg	130	7	role	role	NN
cord-285091-2i2v5ecg	130	8	for	for	IN
cord-285091-2i2v5ecg	130	9	the	the	DT
cord-285091-2i2v5ecg	130	10	lysosomal	lysosomal	JJ
cord-285091-2i2v5ecg	130	11	cysteine	cysteine	NN
cord-285091-2i2v5ecg	130	12	protease	protease	NN
cord-285091-2i2v5ecg	130	13	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	130	14	S	s	NN
cord-285091-2i2v5ecg	130	15	in	in	IN
cord-285091-2i2v5ecg	130	16	the	the	DT
cord-285091-2i2v5ecg	130	17	late	late	JJ
cord-285091-2i2v5ecg	130	18	stages	stage	NNS
cord-285091-2i2v5ecg	130	19	of	of	IN
cord-285091-2i2v5ecg	130	20	Ii	Ii	NNP
cord-285091-2i2v5ecg	130	21	degradation	degradation	NN
cord-285091-2i2v5ecg	130	22	in	in	IN
cord-285091-2i2v5ecg	130	23	B	b	NN
cord-285091-2i2v5ecg	130	24	cells	cell	NNS
cord-285091-2i2v5ecg	130	25	,	,	,
cord-285091-2i2v5ecg	130	26	DCs	dc	NNS
cord-285091-2i2v5ecg	130	27	and	and	CC
cord-285091-2i2v5ecg	130	28	macrophages	macrophage	NNS
cord-285091-2i2v5ecg	130	29	[	[	-LRB-
cord-285091-2i2v5ecg	130	30	89	89	CD
cord-285091-2i2v5ecg	130	31	]	]	-RRB-
cord-285091-2i2v5ecg	130	32	[	[	-LRB-
cord-285091-2i2v5ecg	130	33	90	90	CD
cord-285091-2i2v5ecg	130	34	]	]	-RRB-
cord-285091-2i2v5ecg	130	35	[	[	-LRB-
cord-285091-2i2v5ecg	130	36	91	91	CD
cord-285091-2i2v5ecg	130	37	]	]	-RRB-
cord-285091-2i2v5ecg	130	38	and	and	CC
cord-285091-2i2v5ecg	130	39	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	130	40	L	l	NN
cord-285091-2i2v5ecg	130	41	(	(	-LRB-
cord-285091-2i2v5ecg	130	42	V	v	NN
cord-285091-2i2v5ecg	130	43	in	in	IN
cord-285091-2i2v5ecg	130	44	humans	human	NNS
cord-285091-2i2v5ecg	130	45	)	)	-RRB-
cord-285091-2i2v5ecg	130	46	in	in	IN
cord-285091-2i2v5ecg	130	47	thymic	thymic	JJ
cord-285091-2i2v5ecg	130	48	cortical	cortical	JJ
cord-285091-2i2v5ecg	130	49	epithelium	epithelium	NN
cord-285091-2i2v5ecg	130	50	[	[	-LRB-
cord-285091-2i2v5ecg	130	51	92	92	CD
cord-285091-2i2v5ecg	130	52	]	]	-RRB-
cord-285091-2i2v5ecg	130	53	.	.	.
cord-285091-2i2v5ecg	131	1	It	-PRON-	PRP
cord-285091-2i2v5ecg	131	2	has	have	VBZ
cord-285091-2i2v5ecg	131	3	been	be	VBN
cord-285091-2i2v5ecg	131	4	proposed	propose	VBN
cord-285091-2i2v5ecg	131	5	that	that	IN
cord-285091-2i2v5ecg	131	6	cystatin	cystatin	NNP
cord-285091-2i2v5ecg	131	7	C	C	NNP
cord-285091-2i2v5ecg	131	8	regulates	regulate	VBZ
cord-285091-2i2v5ecg	131	9	the	the	DT
cord-285091-2i2v5ecg	131	10	cleavage	cleavage	NN
cord-285091-2i2v5ecg	131	11	and	and	CC
cord-285091-2i2v5ecg	131	12	removal	removal	NN
cord-285091-2i2v5ecg	131	13	of	of	IN
cord-285091-2i2v5ecg	131	14	the	the	DT
cord-285091-2i2v5ecg	131	15	MHC	MHC	NNP
cord-285091-2i2v5ecg	131	16	class	class	NN
cord-285091-2i2v5ecg	131	17	II	II	NNP
cord-285091-2i2v5ecg	131	18	invariant	invariant	JJ
cord-285091-2i2v5ecg	131	19	chain	chain	NN
cord-285091-2i2v5ecg	131	20	(	(	-LRB-
cord-285091-2i2v5ecg	131	21	Ii	Ii	NNP
cord-285091-2i2v5ecg	131	22	)	)	-RRB-
cord-285091-2i2v5ecg	131	23	by	by	IN
cord-285091-2i2v5ecg	131	24	regulating	regulate	VBG
cord-285091-2i2v5ecg	131	25	the	the	DT
cord-285091-2i2v5ecg	131	26	activity	activity	NN
cord-285091-2i2v5ecg	131	27	of	of	IN
cord-285091-2i2v5ecg	131	28	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	131	29	S	S	NNP
cord-285091-2i2v5ecg	131	30	,	,	,
cord-285091-2i2v5ecg	131	31	and	and	CC
cord-285091-2i2v5ecg	131	32	hence	hence	RB
cord-285091-2i2v5ecg	131	33	in	in	IN
cord-285091-2i2v5ecg	131	34	the	the	DT
cord-285091-2i2v5ecg	131	35	formation	formation	NN
cord-285091-2i2v5ecg	131	36	of	of	IN
cord-285091-2i2v5ecg	131	37	MHC	MHC	NNP
cord-285091-2i2v5ecg	131	38	class	class	NN
cord-285091-2i2v5ecg	131	39	II	II	NNP
cord-285091-2i2v5ecg	131	40	-	-	HYPH
cord-285091-2i2v5ecg	131	41	peptide	peptide	NN
cord-285091-2i2v5ecg	131	42	complexes	complex	NNS
cord-285091-2i2v5ecg	131	43	[	[	-LRB-
cord-285091-2i2v5ecg	131	44	93	93	CD
cord-285091-2i2v5ecg	131	45	]	]	-RRB-
cord-285091-2i2v5ecg	131	46	.	.	.
cord-285091-2i2v5ecg	132	1	Experiments	experiment	NNS
cord-285091-2i2v5ecg	132	2	on	on	IN
cord-285091-2i2v5ecg	132	3	DC	DC	NNP
cord-285091-2i2v5ecg	132	4	isolated	isolate	VBN
cord-285091-2i2v5ecg	132	5	from	from	IN
cord-285091-2i2v5ecg	132	6	cystatin	cystatin	NNP
cord-285091-2i2v5ecg	132	7	C	c	NN
cord-285091-2i2v5ecg	132	8	-	-	HYPH
cord-285091-2i2v5ecg	132	9	deficient	deficient	JJ
cord-285091-2i2v5ecg	132	10	mice	mouse	NNS
cord-285091-2i2v5ecg	132	11	showed	show	VBD
cord-285091-2i2v5ecg	132	12	that	that	IN
cord-285091-2i2v5ecg	132	13	the	the	DT
cord-285091-2i2v5ecg	132	14	lack	lack	NN
cord-285091-2i2v5ecg	132	15	of	of	IN
cord-285091-2i2v5ecg	132	16	cystatin	cystatin	NN
cord-285091-2i2v5ecg	132	17	C	C	NNP
cord-285091-2i2v5ecg	132	18	did	do	VBD
cord-285091-2i2v5ecg	132	19	not	not	RB
cord-285091-2i2v5ecg	132	20	change	change	VB
cord-285091-2i2v5ecg	132	21	the	the	DT
cord-285091-2i2v5ecg	132	22	formation	formation	NN
cord-285091-2i2v5ecg	132	23	of	of	IN
cord-285091-2i2v5ecg	132	24	peptide	peptide	NN
cord-285091-2i2v5ecg	132	25	-	-	HYPH
cord-285091-2i2v5ecg	132	26	loaded	load	VBN
cord-285091-2i2v5ecg	132	27	MHC	MHC	NNP
cord-285091-2i2v5ecg	132	28	class	class	NN
cord-285091-2i2v5ecg	132	29	II	II	NNP
cord-285091-2i2v5ecg	132	30	complexes	complex	NNS
cord-285091-2i2v5ecg	132	31	in	in	IN
cord-285091-2i2v5ecg	132	32	any	any	DT
cord-285091-2i2v5ecg	132	33	of	of	IN
cord-285091-2i2v5ecg	132	34	the	the	DT
cord-285091-2i2v5ecg	132	35	DC	DC	NNP
cord-285091-2i2v5ecg	132	36	types	type	NNS
cord-285091-2i2v5ecg	132	37	,	,	,
cord-285091-2i2v5ecg	132	38	nor	nor	CC
cord-285091-2i2v5ecg	132	39	the	the	DT
cord-285091-2i2v5ecg	132	40	efficiency	efficiency	NN
cord-285091-2i2v5ecg	132	41	of	of	IN
cord-285091-2i2v5ecg	132	42	antigen	antigen	NN
cord-285091-2i2v5ecg	132	43	presentation	presentation	NN
cord-285091-2i2v5ecg	132	44	[	[	-LRB-
cord-285091-2i2v5ecg	132	45	94	94	CD
cord-285091-2i2v5ecg	132	46	]	]	-RRB-
cord-285091-2i2v5ecg	132	47	.	.	.
cord-285091-2i2v5ecg	133	1	Plasmacytoid	Plasmacytoid	NNP
cord-285091-2i2v5ecg	133	2	DCs	dc	NNS
cord-285091-2i2v5ecg	133	3	constitute	constitute	VBP
cord-285091-2i2v5ecg	133	4	a	a	DT
cord-285091-2i2v5ecg	133	5	minor	minor	JJ
cord-285091-2i2v5ecg	133	6	population	population	NN
cord-285091-2i2v5ecg	133	7	of	of	IN
cord-285091-2i2v5ecg	133	8	DCs	DCs	NNP
cord-285091-2i2v5ecg	133	9	;	;	:
cord-285091-2i2v5ecg	133	10	in	in	IN
cord-285091-2i2v5ecg	133	11	the	the	DT
cord-285091-2i2v5ecg	133	12	endolysosomes	endolysosome	NNS
cord-285091-2i2v5ecg	133	13	they	-PRON-	PRP
cord-285091-2i2v5ecg	133	14	express	express	VBP
cord-285091-2i2v5ecg	133	15	TLR7	TLR7	NNP
cord-285091-2i2v5ecg	133	16	and	and	CC
cord-285091-2i2v5ecg	133	17	TLR9	TLR9	NNP
cord-285091-2i2v5ecg	133	18	and	and	CC
cord-285091-2i2v5ecg	133	19	produce	produce	VB
cord-285091-2i2v5ecg	133	20	large	large	JJ
cord-285091-2i2v5ecg	133	21	amounts	amount	NNS
cord-285091-2i2v5ecg	133	22	of	of	IN
cord-285091-2i2v5ecg	133	23	IFNin	IFNin	NNP
cord-285091-2i2v5ecg	133	24	upon	upon	IN
cord-285091-2i2v5ecg	133	25	TLR7	TLR7	NNP
cord-285091-2i2v5ecg	133	26	and	and	CC
cord-285091-2i2v5ecg	133	27	TLR9	tlr9	JJ
cord-285091-2i2v5ecg	133	28	stimulation	stimulation	NN
cord-285091-2i2v5ecg	133	29	by	by	IN
cord-285091-2i2v5ecg	133	30	viral	viral	JJ
cord-285091-2i2v5ecg	133	31	nucleic	nucleic	JJ
cord-285091-2i2v5ecg	133	32	acids	acid	NNS
cord-285091-2i2v5ecg	133	33	[	[	-LRB-
cord-285091-2i2v5ecg	133	34	95	95	CD
cord-285091-2i2v5ecg	133	35	]	]	-RRB-
cord-285091-2i2v5ecg	133	36	.	.	.
cord-285091-2i2v5ecg	134	1	Activated	activate	VBN
cord-285091-2i2v5ecg	134	2	pDCs	pdc	MD
cord-285091-2i2v5ecg	134	3	behave	behave	VBP
cord-285091-2i2v5ecg	134	4	differently	differently	RB
cord-285091-2i2v5ecg	134	5	than	than	IN
cord-285091-2i2v5ecg	134	6	conventional	conventional	JJ
cord-285091-2i2v5ecg	134	7	DCs	dc	NNS
cord-285091-2i2v5ecg	134	8	in	in	IN
cord-285091-2i2v5ecg	134	9	antigen	antigen	NN
cord-285091-2i2v5ecg	134	10	presentation	presentation	NN
cord-285091-2i2v5ecg	134	11	following	follow	VBG
cord-285091-2i2v5ecg	134	12	activation	activation	NN
cord-285091-2i2v5ecg	134	13	via	via	IN
cord-285091-2i2v5ecg	134	14	TLR9	TLR9	NNP
cord-285091-2i2v5ecg	134	15	ligands	ligand	NNS
cord-285091-2i2v5ecg	134	16	such	such	JJ
cord-285091-2i2v5ecg	134	17	as	as	IN
cord-285091-2i2v5ecg	134	18	CpG	CpG	NNP
cord-285091-2i2v5ecg	134	19	DNA	DNA	NNP
cord-285091-2i2v5ecg	134	20	.	.	.
cord-285091-2i2v5ecg	135	1	In	in	IN
cord-285091-2i2v5ecg	135	2	models	model	NNS
cord-285091-2i2v5ecg	135	3	of	of	IN
cord-285091-2i2v5ecg	135	4	influenza	influenza	NN
cord-285091-2i2v5ecg	135	5	infection	infection	NN
cord-285091-2i2v5ecg	135	6	,	,	,
cord-285091-2i2v5ecg	135	7	conventional	conventional	JJ
cord-285091-2i2v5ecg	135	8	DCs	dc	NNS
cord-285091-2i2v5ecg	135	9	undergo	undergo	VBP
cord-285091-2i2v5ecg	135	10	maturation	maturation	NN
cord-285091-2i2v5ecg	135	11	and	and	CC
cord-285091-2i2v5ecg	135	12	present	present	JJ
cord-285091-2i2v5ecg	135	13	antigens	antigen	NNS
cord-285091-2i2v5ecg	135	14	in	in	IN
cord-285091-2i2v5ecg	135	15	complex	complex	NN
cord-285091-2i2v5ecg	135	16	with	with	IN
cord-285091-2i2v5ecg	135	17	MHC	MHC	NNP
cord-285091-2i2v5ecg	135	18	class	class	NN
cord-285091-2i2v5ecg	135	19	II	II	NNP
cord-285091-2i2v5ecg	135	20	,	,	,
cord-285091-2i2v5ecg	135	21	with	with	IN
cord-285091-2i2v5ecg	135	22	a	a	DT
cord-285091-2i2v5ecg	135	23	parallel	parallel	JJ
cord-285091-2i2v5ecg	135	24	downregulation	downregulation	NN
cord-285091-2i2v5ecg	135	25	of	of	IN
cord-285091-2i2v5ecg	135	26	MHC	MHC	NNP
cord-285091-2i2v5ecg	135	27	II	II	NNP
cord-285091-2i2v5ecg	135	28	synthesis	synthesis	NN
cord-285091-2i2v5ecg	135	29	.	.	.
cord-285091-2i2v5ecg	136	1	Although	although	IN
cord-285091-2i2v5ecg	136	2	pDCs	pdcs	PRP
cord-285091-2i2v5ecg	136	3	also	also	RB
cord-285091-2i2v5ecg	136	4	undergo	undergo	VBP
cord-285091-2i2v5ecg	136	5	maturation	maturation	NN
cord-285091-2i2v5ecg	136	6	and	and	CC
cord-285091-2i2v5ecg	136	7	present	present	JJ
cord-285091-2i2v5ecg	136	8	antigens	antigen	NNS
cord-285091-2i2v5ecg	136	9	,	,	,
cord-285091-2i2v5ecg	136	10	MHC	MHC	NNP
cord-285091-2i2v5ecg	136	11	class	class	NN
cord-285091-2i2v5ecg	136	12	II	II	NNP
cord-285091-2i2v5ecg	136	13	molecules	molecule	NNS
cord-285091-2i2v5ecg	136	14	synthesis	synthesis	NN
cord-285091-2i2v5ecg	136	15	is	be	VBZ
cord-285091-2i2v5ecg	136	16	not	not	RB
cord-285091-2i2v5ecg	136	17	down	down	RB
cord-285091-2i2v5ecg	136	18	-	-	HYPH
cord-285091-2i2v5ecg	136	19	regulated	regulate	VBN
cord-285091-2i2v5ecg	136	20	upon	upon	IN
cord-285091-2i2v5ecg	136	21	stimulation	stimulation	NN
cord-285091-2i2v5ecg	136	22	with	with	IN
cord-285091-2i2v5ecg	136	23	TLR	TLR	NNP
cord-285091-2i2v5ecg	136	24	ligands	ligand	NNS
cord-285091-2i2v5ecg	136	25	,	,	,
cord-285091-2i2v5ecg	136	26	indicating	indicate	VBG
cord-285091-2i2v5ecg	136	27	that	that	IN
cord-285091-2i2v5ecg	136	28	the	the	DT
cord-285091-2i2v5ecg	136	29	pDCs	pdcs	NN
cord-285091-2i2v5ecg	136	30	have	have	VBP
cord-285091-2i2v5ecg	136	31	the	the	DT
cord-285091-2i2v5ecg	136	32	ability	ability	NN
cord-285091-2i2v5ecg	136	33	to	to	TO
cord-285091-2i2v5ecg	136	34	continuously	continuously	RB
cord-285091-2i2v5ecg	136	35	present	present	VB
cord-285091-2i2v5ecg	136	36	viral	viral	JJ
cord-285091-2i2v5ecg	136	37	antigens	antigen	NNS
cord-285091-2i2v5ecg	136	38	in	in	IN
cord-285091-2i2v5ecg	136	39	activated	activate	VBN
cord-285091-2i2v5ecg	136	40	state	state	NN
cord-285091-2i2v5ecg	136	41	[	[	-LRB-
cord-285091-2i2v5ecg	136	42	83	83	CD
cord-285091-2i2v5ecg	136	43	]	]	-RRB-
cord-285091-2i2v5ecg	136	44	.	.	.
cord-285091-2i2v5ecg	137	1	TLR	TLR	NNP
cord-285091-2i2v5ecg	137	2	recognition	recognition	NN
cord-285091-2i2v5ecg	137	3	of	of	IN
cord-285091-2i2v5ecg	137	4	viruses	virus	NNS
cord-285091-2i2v5ecg	137	5	leads	lead	VBZ
cord-285091-2i2v5ecg	137	6	to	to	IN
cord-285091-2i2v5ecg	137	7	IFN	IFN	NNP
cord-285091-2i2v5ecg	137	8	-	-	HYPH
cord-285091-2i2v5ecg	137	9	production	production	NN
cord-285091-2i2v5ecg	137	10	,	,	,
cord-285091-2i2v5ecg	137	11	which	which	WDT
cord-285091-2i2v5ecg	137	12	positively	positively	RB
cord-285091-2i2v5ecg	137	13	feedbacks	feedback	VBZ
cord-285091-2i2v5ecg	137	14	via	via	IN
cord-285091-2i2v5ecg	137	15	interferon	interferon	NN
cord-285091-2i2v5ecg	137	16	receptor	receptor	NN
cord-285091-2i2v5ecg	137	17	to	to	TO
cord-285091-2i2v5ecg	137	18	drive	drive	VB
cord-285091-2i2v5ecg	137	19	further	further	JJ
cord-285091-2i2v5ecg	137	20	type	type	NN
cord-285091-2i2v5ecg	138	1	I	-PRON-	PRP
cord-285091-2i2v5ecg	138	2	IFN	IFN	NNP
cord-285091-2i2v5ecg	138	3	production	production	NN
cord-285091-2i2v5ecg	138	4	by	by	IN
cord-285091-2i2v5ecg	138	5	pDCs	pdcs	XX
cord-285091-2i2v5ecg	138	6	[	[	-LRB-
cord-285091-2i2v5ecg	138	7	82	82	CD
cord-285091-2i2v5ecg	138	8	]	]	-RRB-
cord-285091-2i2v5ecg	138	9	.	.	.
cord-285091-2i2v5ecg	139	1	In	in	IN
cord-285091-2i2v5ecg	139	2	the	the	DT
cord-285091-2i2v5ecg	139	3	steady	steady	JJ
cord-285091-2i2v5ecg	139	4	state	state	NN
cord-285091-2i2v5ecg	139	5	,	,	,
cord-285091-2i2v5ecg	139	6	TLR3	TLR3	NNP
cord-285091-2i2v5ecg	139	7	,	,	,
cord-285091-2i2v5ecg	139	8	TLR7	TLR7	NNP
cord-285091-2i2v5ecg	139	9	and	and	CC
cord-285091-2i2v5ecg	139	10	TLR9	TLR9	NNP
cord-285091-2i2v5ecg	139	11	are	be	VBP
cord-285091-2i2v5ecg	139	12	mostly	mostly	RB
cord-285091-2i2v5ecg	139	13	sequestered	sequester	VBN
cord-285091-2i2v5ecg	139	14	in	in	IN
cord-285091-2i2v5ecg	139	15	the	the	DT
cord-285091-2i2v5ecg	139	16	endoplasmic	endoplasmic	NN
cord-285091-2i2v5ecg	139	17	reticulum	reticulum	NN
cord-285091-2i2v5ecg	139	18	[	[	-LRB-
cord-285091-2i2v5ecg	139	19	18	18	CD
cord-285091-2i2v5ecg	139	20	]	]	-RRB-
cord-285091-2i2v5ecg	139	21	and	and	CC
cord-285091-2i2v5ecg	139	22	are	be	VBP
cord-285091-2i2v5ecg	139	23	transported	transport	VBN
cord-285091-2i2v5ecg	139	24	into	into	IN
cord-285091-2i2v5ecg	139	25	endosomes	endosome	NNS
cord-285091-2i2v5ecg	139	26	upon	upon	IN
cord-285091-2i2v5ecg	139	27	the	the	DT
cord-285091-2i2v5ecg	139	28	activation	activation	NN
cord-285091-2i2v5ecg	139	29	with	with	IN
cord-285091-2i2v5ecg	139	30	ligands	ligand	NNS
cord-285091-2i2v5ecg	139	31	[	[	-LRB-
cord-285091-2i2v5ecg	139	32	96	96	CD
cord-285091-2i2v5ecg	139	33	,	,	,
cord-285091-2i2v5ecg	139	34	97	97	CD
cord-285091-2i2v5ecg	139	35	]	]	-RRB-
cord-285091-2i2v5ecg	139	36	.	.	.
cord-285091-2i2v5ecg	140	1	An	an	DT
cord-285091-2i2v5ecg	140	2	additional	additional	JJ
cord-285091-2i2v5ecg	140	3	level	level	NN
cord-285091-2i2v5ecg	140	4	of	of	IN
cord-285091-2i2v5ecg	140	5	control	control	NN
cord-285091-2i2v5ecg	140	6	is	be	VBZ
cord-285091-2i2v5ecg	140	7	achieved	achieve	VBN
cord-285091-2i2v5ecg	140	8	by	by	IN
cord-285091-2i2v5ecg	140	9	the	the	DT
cord-285091-2i2v5ecg	140	10	proteolysis	proteolysis	NN
cord-285091-2i2v5ecg	140	11	full	full	JJ
cord-285091-2i2v5ecg	140	12	length	length	NN
cord-285091-2i2v5ecg	140	13	TLR7	TLR7	NNP
cord-285091-2i2v5ecg	140	14	and	and	CC
cord-285091-2i2v5ecg	140	15	TLR9	TLR9	NNP
cord-285091-2i2v5ecg	140	16	by	by	IN
cord-285091-2i2v5ecg	140	17	endosomal	endosomal	NNP
cord-285091-2i2v5ecg	140	18	cysteine	cysteine	NN
cord-285091-2i2v5ecg	140	19	cathepsins	cathepsin	NNS
cord-285091-2i2v5ecg	140	20	and	and	CC
cord-285091-2i2v5ecg	140	21	AEP.TLR9	AEP.TLR9	NNP
cord-285091-2i2v5ecg	140	22	can	can	MD
cord-285091-2i2v5ecg	140	23	bind	bind	VB
cord-285091-2i2v5ecg	140	24	its	-PRON-	PRP$
cord-285091-2i2v5ecg	140	25	ligand	ligand	NN
cord-285091-2i2v5ecg	140	26	CpG	CpG	NNP
cord-285091-2i2v5ecg	140	27	DNA	DNA	NNP
cord-285091-2i2v5ecg	140	28	,	,	,
cord-285091-2i2v5ecg	140	29	but	but	CC
cord-285091-2i2v5ecg	140	30	it	-PRON-	PRP
cord-285091-2i2v5ecg	140	31	can	can	MD
cord-285091-2i2v5ecg	140	32	not	not	RB
cord-285091-2i2v5ecg	140	33	trigger	trigger	VB
cord-285091-2i2v5ecg	140	34	activation	activation	NN
cord-285091-2i2v5ecg	140	35	signals	signal	NNS
cord-285091-2i2v5ecg	140	36	without	without	IN
cord-285091-2i2v5ecg	140	37	first	first	RB
cord-285091-2i2v5ecg	140	38	being	be	VBG
cord-285091-2i2v5ecg	140	39	processed	process	VBN
cord-285091-2i2v5ecg	140	40	by	by	IN
cord-285091-2i2v5ecg	140	41	endolysosomal	endolysosomal	JJ
cord-285091-2i2v5ecg	140	42	proteases	protease	NNS
cord-285091-2i2v5ecg	140	43	,	,	,
cord-285091-2i2v5ecg	140	44	which	which	WDT
cord-285091-2i2v5ecg	140	45	remove	remove	VBP
cord-285091-2i2v5ecg	140	46	N	n	CD
cord-285091-2i2v5ecg	140	47	-	-	HYPH
cord-285091-2i2v5ecg	140	48	terminal	terminal	NN
cord-285091-2i2v5ecg	140	49	region	region	NN
cord-285091-2i2v5ecg	140	50	[	[	-LRB-
cord-285091-2i2v5ecg	140	51	98	98	CD
cord-285091-2i2v5ecg	140	52	]	]	-RRB-
cord-285091-2i2v5ecg	141	1	[	[	-LRB-
cord-285091-2i2v5ecg	141	2	99	99	CD
cord-285091-2i2v5ecg	141	3	]	]	-RRB-
cord-285091-2i2v5ecg	141	4	[	[	-LRB-
cord-285091-2i2v5ecg	141	5	100	100	CD
cord-285091-2i2v5ecg	141	6	]	]	-RRB-
cord-285091-2i2v5ecg	141	7	[	[	-LRB-
cord-285091-2i2v5ecg	141	8	101	101	CD
cord-285091-2i2v5ecg	141	9	]	]	-RRB-
cord-285091-2i2v5ecg	141	10	.	.	.
cord-285091-2i2v5ecg	142	1	Cells	cell	NNS
cord-285091-2i2v5ecg	142	2	derived	derive	VBN
cord-285091-2i2v5ecg	142	3	from	from	IN
cord-285091-2i2v5ecg	142	4	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	142	5	B	B	NNP
cord-285091-2i2v5ecg	142	6	,	,	,
cord-285091-2i2v5ecg	142	7	L	L	NNP
cord-285091-2i2v5ecg	142	8	,	,	,
cord-285091-2i2v5ecg	142	9	K	K	NNP
cord-285091-2i2v5ecg	142	10	and	and	CC
cord-285091-2i2v5ecg	142	11	S	S	NNP
cord-285091-2i2v5ecg	142	12	deficient	deficient	JJ
cord-285091-2i2v5ecg	142	13	mice	mouse	NNS
cord-285091-2i2v5ecg	142	14	show	show	VBP
cord-285091-2i2v5ecg	142	15	that	that	IN
cord-285091-2i2v5ecg	142	16	no	no	DT
cord-285091-2i2v5ecg	142	17	single	single	JJ
cord-285091-2i2v5ecg	142	18	protease	protease	NN
cord-285091-2i2v5ecg	142	19	is	be	VBZ
cord-285091-2i2v5ecg	142	20	responsible	responsible	JJ
cord-285091-2i2v5ecg	142	21	for	for	IN
cord-285091-2i2v5ecg	142	22	TLR7	TLR7	NNP
cord-285091-2i2v5ecg	142	23	or	or	CC
cord-285091-2i2v5ecg	142	24	TLR9	TLR9	NNP
cord-285091-2i2v5ecg	142	25	processing	processing	NN
cord-285091-2i2v5ecg	142	26	,	,	,
cord-285091-2i2v5ecg	142	27	indicating	indicate	VBG
cord-285091-2i2v5ecg	142	28	that	that	IN
cord-285091-2i2v5ecg	142	29	there	there	EX
cord-285091-2i2v5ecg	142	30	is	be	VBZ
cord-285091-2i2v5ecg	142	31	redundancy	redundancy	NN
cord-285091-2i2v5ecg	142	32	in	in	IN
cord-285091-2i2v5ecg	142	33	this	this	DT
cord-285091-2i2v5ecg	142	34	reaction	reaction	NN
cord-285091-2i2v5ecg	142	35	[	[	-LRB-
cord-285091-2i2v5ecg	142	36	99	99	CD
cord-285091-2i2v5ecg	142	37	,	,	,
cord-285091-2i2v5ecg	142	38	101	101	CD
cord-285091-2i2v5ecg	142	39	]	]	-RRB-
cord-285091-2i2v5ecg	142	40	.	.	.
cord-285091-2i2v5ecg	143	1	The	the	DT
cord-285091-2i2v5ecg	143	2	role	role	NN
cord-285091-2i2v5ecg	143	3	of	of	IN
cord-285091-2i2v5ecg	143	4	endogenous	endogenous	JJ
cord-285091-2i2v5ecg	143	5	inhibitors	inhibitor	NNS
cord-285091-2i2v5ecg	143	6	in	in	IN
cord-285091-2i2v5ecg	143	7	this	this	DT
cord-285091-2i2v5ecg	143	8	process	process	NN
cord-285091-2i2v5ecg	143	9	remains	remain	VBZ
cord-285091-2i2v5ecg	143	10	to	to	TO
cord-285091-2i2v5ecg	143	11	be	be	VB
cord-285091-2i2v5ecg	143	12	fully	fully	RB
cord-285091-2i2v5ecg	143	13	elucidated	elucidate	VBN
cord-285091-2i2v5ecg	143	14	.	.	.
cord-285091-2i2v5ecg	144	1	Many	many	JJ
cord-285091-2i2v5ecg	144	2	pathogens	pathogen	NNS
cord-285091-2i2v5ecg	144	3	also	also	RB
cord-285091-2i2v5ecg	144	4	synthesize	synthesize	VBP
cord-285091-2i2v5ecg	144	5	cysteine	cysteine	NN
cord-285091-2i2v5ecg	144	6	proteases	protease	NNS
cord-285091-2i2v5ecg	144	7	that	that	WDT
cord-285091-2i2v5ecg	144	8	act	act	VBP
cord-285091-2i2v5ecg	144	9	on	on	IN
cord-285091-2i2v5ecg	144	10	target	target	NN
cord-285091-2i2v5ecg	144	11	proteins	protein	NNS
cord-285091-2i2v5ecg	144	12	in	in	IN
cord-285091-2i2v5ecg	144	13	the	the	DT
cord-285091-2i2v5ecg	144	14	host	host	NN
cord-285091-2i2v5ecg	144	15	and	and	CC
cord-285091-2i2v5ecg	144	16	thereby	thereby	RB
cord-285091-2i2v5ecg	144	17	modulate	modulate	VB
cord-285091-2i2v5ecg	144	18	host	host	NN
cord-285091-2i2v5ecg	144	19	immune	immune	JJ
cord-285091-2i2v5ecg	144	20	response	response	NN
cord-285091-2i2v5ecg	144	21	.	.	.
cord-285091-2i2v5ecg	145	1	Pathogen	pathogen	NN
cord-285091-2i2v5ecg	145	2	-	-	HYPH
cord-285091-2i2v5ecg	145	3	derived	derive	VBN
cord-285091-2i2v5ecg	145	4	proteases	protease	NNS
cord-285091-2i2v5ecg	145	5	range	range	VBP
cord-285091-2i2v5ecg	145	6	from	from	IN
cord-285091-2i2v5ecg	145	7	nonspecific	nonspecific	JJ
cord-285091-2i2v5ecg	145	8	proteases	protease	NNS
cord-285091-2i2v5ecg	145	9	that	that	WDT
cord-285091-2i2v5ecg	145	10	degrade	degrade	VBP
cord-285091-2i2v5ecg	145	11	multiple	multiple	JJ
cord-285091-2i2v5ecg	145	12	proteins	protein	NNS
cord-285091-2i2v5ecg	145	13	involved	involve	VBN
cord-285091-2i2v5ecg	145	14	in	in	IN
cord-285091-2i2v5ecg	145	15	the	the	DT
cord-285091-2i2v5ecg	145	16	immune	immune	JJ
cord-285091-2i2v5ecg	145	17	response	response	NN
cord-285091-2i2v5ecg	145	18	to	to	IN
cord-285091-2i2v5ecg	145	19	enzymes	enzyme	NNS
cord-285091-2i2v5ecg	145	20	that	that	WDT
cord-285091-2i2v5ecg	145	21	are	be	VBP
cord-285091-2i2v5ecg	145	22	very	very	RB
cord-285091-2i2v5ecg	145	23	specific	specific	JJ
cord-285091-2i2v5ecg	145	24	in	in	IN
cord-285091-2i2v5ecg	145	25	their	-PRON-	PRP$
cord-285091-2i2v5ecg	145	26	mode	mode	NN
cord-285091-2i2v5ecg	145	27	of	of	IN
cord-285091-2i2v5ecg	145	28	action	action	NN
cord-285091-2i2v5ecg	145	29	.	.	.
cord-285091-2i2v5ecg	146	1	Staphylococcus	Staphylococcus	NNP
cord-285091-2i2v5ecg	146	2	aureus	aureus	NN
cord-285091-2i2v5ecg	146	3	is	be	VBZ
cord-285091-2i2v5ecg	146	4	the	the	DT
cord-285091-2i2v5ecg	146	5	most	most	RBS
cord-285091-2i2v5ecg	146	6	frequently	frequently	RB
cord-285091-2i2v5ecg	146	7	isolated	isolate	VBN
cord-285091-2i2v5ecg	146	8	pathogen	pathogen	NN
cord-285091-2i2v5ecg	146	9	in	in	IN
cord-285091-2i2v5ecg	146	10	gram	gram	NN
cord-285091-2i2v5ecg	146	11	-	-	HYPH
cord-285091-2i2v5ecg	146	12	positive	positive	JJ
cord-285091-2i2v5ecg	146	13	sepsis	sepsis	NN
cord-285091-2i2v5ecg	146	14	.	.	.
cord-285091-2i2v5ecg	147	1	Among	among	IN
cord-285091-2i2v5ecg	147	2	others	other	NNS
cord-285091-2i2v5ecg	147	3	,	,	,
cord-285091-2i2v5ecg	147	4	S.	S.	NNP
cord-285091-2i2v5ecg	147	5	aureus	aureus	NN
cord-285091-2i2v5ecg	147	6	secretes	secrete	VBZ
cord-285091-2i2v5ecg	147	7	papain	papain	NN
cord-285091-2i2v5ecg	147	8	-	-	HYPH
cord-285091-2i2v5ecg	147	9	like	like	JJ
cord-285091-2i2v5ecg	147	10	cysteine	cysteine	NN
cord-285091-2i2v5ecg	147	11	proteases	protease	NNS
cord-285091-2i2v5ecg	147	12	:	:	:
cord-285091-2i2v5ecg	147	13	staphopain	staphopain	NNP
cord-285091-2i2v5ecg	147	14	A	A	NNP
cord-285091-2i2v5ecg	147	15	(	(	-LRB-
cord-285091-2i2v5ecg	147	16	ScpA	ScpA	NNP
cord-285091-2i2v5ecg	147	17	)	)	-RRB-
cord-285091-2i2v5ecg	147	18	and	and	CC
cord-285091-2i2v5ecg	147	19	staphopain	staphopain	NNP
cord-285091-2i2v5ecg	147	20	B	B	NNP
cord-285091-2i2v5ecg	147	21	(	(	-LRB-
cord-285091-2i2v5ecg	147	22	SspB	SspB	NNP
cord-285091-2i2v5ecg	147	23	)	)	-RRB-
cord-285091-2i2v5ecg	147	24	.	.	.
cord-285091-2i2v5ecg	148	1	It	-PRON-	PRP
cord-285091-2i2v5ecg	148	2	was	be	VBD
cord-285091-2i2v5ecg	148	3	reported	report	VBN
cord-285091-2i2v5ecg	148	4	that	that	IN
cord-285091-2i2v5ecg	148	5	enzymatically	enzymatically	RB
cord-285091-2i2v5ecg	148	6	active	active	JJ
cord-285091-2i2v5ecg	148	7	staphopains	staphopain	NNS
cord-285091-2i2v5ecg	148	8	degraded	degrade	VBD
cord-285091-2i2v5ecg	148	9	collagen	collagen	NN
cord-285091-2i2v5ecg	148	10	and	and	CC
cord-285091-2i2v5ecg	148	11	fibrinogen	fibrinogen	NN
cord-285091-2i2v5ecg	148	12	in	in	IN
cord-285091-2i2v5ecg	148	13	the	the	DT
cord-285091-2i2v5ecg	148	14	host	host	NN
cord-285091-2i2v5ecg	148	15	,	,	,
cord-285091-2i2v5ecg	148	16	and	and	CC
cord-285091-2i2v5ecg	148	17	the	the	DT
cord-285091-2i2v5ecg	148	18	authors	author	NNS
cord-285091-2i2v5ecg	148	19	suggested	suggest	VBD
cord-285091-2i2v5ecg	148	20	that	that	IN
cord-285091-2i2v5ecg	148	21	these	these	DT
cord-285091-2i2v5ecg	148	22	activities	activity	NNS
cord-285091-2i2v5ecg	148	23	could	could	MD
cord-285091-2i2v5ecg	148	24	contribute	contribute	VB
cord-285091-2i2v5ecg	148	25	in	in	IN
cord-285091-2i2v5ecg	148	26	the	the	DT
cord-285091-2i2v5ecg	148	27	clotting	clotting	NN
cord-285091-2i2v5ecg	148	28	impairment	impairment	NN
cord-285091-2i2v5ecg	148	29	and	and	CC
cord-285091-2i2v5ecg	148	30	tissue	tissue	NN
cord-285091-2i2v5ecg	148	31	destruction	destruction	NN
cord-285091-2i2v5ecg	148	32	caused	cause	VBN
cord-285091-2i2v5ecg	148	33	by	by	IN
cord-285091-2i2v5ecg	148	34	staphylococcal	staphylococcal	JJ
cord-285091-2i2v5ecg	148	35	infection	infection	NN
cord-285091-2i2v5ecg	148	36	[	[	-LRB-
cord-285091-2i2v5ecg	148	37	102	102	CD
cord-285091-2i2v5ecg	148	38	]	]	-RRB-
cord-285091-2i2v5ecg	148	39	.	.	.
cord-285091-2i2v5ecg	149	1	Chemerin	Chemerin	NNP
cord-285091-2i2v5ecg	149	2	is	be	VBZ
cord-285091-2i2v5ecg	149	3	a	a	DT
cord-285091-2i2v5ecg	149	4	proinflammatory	proinflammatory	JJ
cord-285091-2i2v5ecg	149	5	plasma	plasma	NN
cord-285091-2i2v5ecg	149	6	protein	protein	NN
cord-285091-2i2v5ecg	149	7	that	that	WDT
cord-285091-2i2v5ecg	149	8	binds	bind	VBZ
cord-285091-2i2v5ecg	149	9	to	to	IN
cord-285091-2i2v5ecg	149	10	the	the	DT
cord-285091-2i2v5ecg	149	11	serpentine	serpentine	JJ
cord-285091-2i2v5ecg	149	12	receptor	receptor	NN
cord-285091-2i2v5ecg	149	13	CMKLR1	cmklr1	NN
cord-285091-2i2v5ecg	149	14	on	on	IN
cord-285091-2i2v5ecg	149	15	macrophages	macrophage	NNS
cord-285091-2i2v5ecg	149	16	and	and	CC
cord-285091-2i2v5ecg	149	17	plasmacytoid	plasmacytoid	NNP
cord-285091-2i2v5ecg	149	18	dendritic	dendritic	JJ
cord-285091-2i2v5ecg	149	19	cells	cell	NNS
cord-285091-2i2v5ecg	149	20	and	and	CC
cord-285091-2i2v5ecg	149	21	promotes	promote	VBZ
cord-285091-2i2v5ecg	149	22	chemotaxis	chemotaxis	NN
cord-285091-2i2v5ecg	149	23	[	[	-LRB-
cord-285091-2i2v5ecg	149	24	103	103	CD
cord-285091-2i2v5ecg	149	25	]	]	-RRB-
cord-285091-2i2v5ecg	149	26	.	.	.
cord-285091-2i2v5ecg	150	1	It	-PRON-	PRP
cord-285091-2i2v5ecg	150	2	is	be	VBZ
cord-285091-2i2v5ecg	150	3	secreted	secrete	VBN
cord-285091-2i2v5ecg	150	4	as	as	IN
cord-285091-2i2v5ecg	150	5	a	a	DT
cord-285091-2i2v5ecg	150	6	precursor	precursor	NN
cord-285091-2i2v5ecg	150	7	protein	protein	NN
cord-285091-2i2v5ecg	150	8	and	and	CC
cord-285091-2i2v5ecg	150	9	activated	activate	VBD
cord-285091-2i2v5ecg	150	10	upon	upon	IN
cord-285091-2i2v5ecg	150	11	proteolytic	proteolytic	JJ
cord-285091-2i2v5ecg	150	12	cleavage	cleavage	NN
cord-285091-2i2v5ecg	150	13	of	of	IN
cord-285091-2i2v5ecg	150	14	its	-PRON-	PRP$
cord-285091-2i2v5ecg	150	15	C	c	NN
cord-285091-2i2v5ecg	150	16	-	-	HYPH
cord-285091-2i2v5ecg	150	17	terminus	terminus	NN
cord-285091-2i2v5ecg	150	18	by	by	IN
cord-285091-2i2v5ecg	150	19	serine	serine	JJ
cord-285091-2i2v5ecg	150	20	proteases	protease	NNS
cord-285091-2i2v5ecg	150	21	of	of	IN
cord-285091-2i2v5ecg	150	22	the	the	DT
cord-285091-2i2v5ecg	150	23	coagulation	coagulation	NN
cord-285091-2i2v5ecg	150	24	,	,	,
cord-285091-2i2v5ecg	150	25	fibrinolytic	fibrinolytic	NN
cord-285091-2i2v5ecg	150	26	,	,	,
cord-285091-2i2v5ecg	150	27	and	and	CC
cord-285091-2i2v5ecg	150	28	inflammatory	inflammatory	JJ
cord-285091-2i2v5ecg	150	29	cascades	cascade	NNS
cord-285091-2i2v5ecg	150	30	[	[	-LRB-
cord-285091-2i2v5ecg	150	31	104	104	CD
cord-285091-2i2v5ecg	150	32	]	]	-RRB-
cord-285091-2i2v5ecg	150	33	,	,	,
cord-285091-2i2v5ecg	150	34	as	as	RB
cord-285091-2i2v5ecg	150	35	well	well	RB
cord-285091-2i2v5ecg	150	36	as	as	IN
cord-285091-2i2v5ecg	150	37	human	human	JJ
cord-285091-2i2v5ecg	150	38	cathepsins	cathepsin	NNS
cord-285091-2i2v5ecg	150	39	K	K	NNP
cord-285091-2i2v5ecg	150	40	and	and	CC
cord-285091-2i2v5ecg	150	41	L	L	NNP
cord-285091-2i2v5ecg	150	42	[	[	-LRB-
cord-285091-2i2v5ecg	150	43	105	105	CD
cord-285091-2i2v5ecg	150	44	]	]	-RRB-
cord-285091-2i2v5ecg	150	45	.	.	.
cord-285091-2i2v5ecg	151	1	SspB	SspB	NNP
cord-285091-2i2v5ecg	151	2	was	be	VBD
cord-285091-2i2v5ecg	151	3	reported	report	VBN
cord-285091-2i2v5ecg	151	4	to	to	TO
cord-285091-2i2v5ecg	151	5	cleave	cleave	VB
cord-285091-2i2v5ecg	151	6	and	and	CC
cord-285091-2i2v5ecg	151	7	activate	activate	VB
cord-285091-2i2v5ecg	151	8	chemerin	chemerin	NNP
cord-285091-2i2v5ecg	151	9	[	[	-LRB-
cord-285091-2i2v5ecg	151	10	106	106	CD
cord-285091-2i2v5ecg	151	11	]	]	-RRB-
cord-285091-2i2v5ecg	151	12	.	.	.
cord-285091-2i2v5ecg	152	1	It	-PRON-	PRP
cord-285091-2i2v5ecg	152	2	was	be	VBD
cord-285091-2i2v5ecg	152	3	proposed	propose	VBN
cord-285091-2i2v5ecg	152	4	that	that	IN
cord-285091-2i2v5ecg	152	5	SspB	SspB	NNP
cord-285091-2i2v5ecg	152	6	may	may	MD
cord-285091-2i2v5ecg	152	7	help	help	VB
cord-285091-2i2v5ecg	152	8	to	to	TO
cord-285091-2i2v5ecg	152	9	recruit	recruit	VB
cord-285091-2i2v5ecg	152	10	pDC	pDC	NNP
cord-285091-2i2v5ecg	152	11	and	and	CC
cord-285091-2i2v5ecg	152	12	macrophages	macrophage	NNS
cord-285091-2i2v5ecg	152	13	at	at	IN
cord-285091-2i2v5ecg	152	14	the	the	DT
cord-285091-2i2v5ecg	152	15	site	site	NN
cord-285091-2i2v5ecg	152	16	of	of	IN
cord-285091-2i2v5ecg	152	17	infection	infection	NN
cord-285091-2i2v5ecg	152	18	and	and	CC
cord-285091-2i2v5ecg	152	19	contribute	contribute	VB
cord-285091-2i2v5ecg	152	20	to	to	IN
cord-285091-2i2v5ecg	152	21	the	the	DT
cord-285091-2i2v5ecg	152	22	ability	ability	NN
cord-285091-2i2v5ecg	152	23	of	of	IN
cord-285091-2i2v5ecg	152	24	bacteria	bacteria	NNS
cord-285091-2i2v5ecg	152	25	to	to	TO
cord-285091-2i2v5ecg	152	26	elicit	elicit	VB
cord-285091-2i2v5ecg	152	27	and	and	CC
cord-285091-2i2v5ecg	152	28	maintain	maintain	VB
cord-285091-2i2v5ecg	152	29	a	a	DT
cord-285091-2i2v5ecg	152	30	chronic	chronic	JJ
cord-285091-2i2v5ecg	152	31	inflammation	inflammation	NN
cord-285091-2i2v5ecg	152	32	[	[	-LRB-
cord-285091-2i2v5ecg	152	33	106	106	CD
cord-285091-2i2v5ecg	152	34	]	]	-RRB-
cord-285091-2i2v5ecg	152	35	.	.	.
cord-285091-2i2v5ecg	153	1	In	in	IN
cord-285091-2i2v5ecg	153	2	silico	silico	NN
cord-285091-2i2v5ecg	153	3	studies	study	NNS
cord-285091-2i2v5ecg	153	4	revealed	reveal	VBD
cord-285091-2i2v5ecg	153	5	the	the	DT
cord-285091-2i2v5ecg	153	6	presence	presence	NN
cord-285091-2i2v5ecg	153	7	of	of	IN
cord-285091-2i2v5ecg	153	8	cystatin	cystatin	NNP
cord-285091-2i2v5ecg	153	9	superfamily	superfamily	NNP
cord-285091-2i2v5ecg	153	10	representatives	representative	NNS
cord-285091-2i2v5ecg	153	11	in	in	IN
cord-285091-2i2v5ecg	153	12	bacterial	bacterial	JJ
cord-285091-2i2v5ecg	153	13	genomes	genome	NNS
cord-285091-2i2v5ecg	153	14	and	and	CC
cord-285091-2i2v5ecg	153	15	only	only	RB
cord-285091-2i2v5ecg	153	16	some	some	DT
cord-285091-2i2v5ecg	153	17	of	of	IN
cord-285091-2i2v5ecg	153	18	them	-PRON-	PRP
cord-285091-2i2v5ecg	153	19	were	be	VBD
cord-285091-2i2v5ecg	153	20	pathogens	pathogen	NNS
cord-285091-2i2v5ecg	153	21	of	of	IN
cord-285091-2i2v5ecg	153	22	humans	human	NNS
cord-285091-2i2v5ecg	153	23	(	(	-LRB-
cord-285091-2i2v5ecg	153	24	V.	V.	NNP
cord-285091-2i2v5ecg	153	25	cholerae	cholerae	NN
cord-285091-2i2v5ecg	153	26	and	and	CC
cord-285091-2i2v5ecg	153	27	V.	V.	NNP
cord-285091-2i2v5ecg	153	28	vulnificu	vulnificu	NNP
cord-285091-2i2v5ecg	153	29	)	)	-RRB-
cord-285091-2i2v5ecg	153	30	[	[	-LRB-
cord-285091-2i2v5ecg	153	31	107	107	CD
cord-285091-2i2v5ecg	153	32	]	]	-RRB-
cord-285091-2i2v5ecg	153	33	.	.	.
cord-285091-2i2v5ecg	154	1	Since	since	IN
cord-285091-2i2v5ecg	154	2	bacterial	bacterial	JJ
cord-285091-2i2v5ecg	154	3	cystatins	cystatin	NNS
cord-285091-2i2v5ecg	154	4	are	be	VBP
cord-285091-2i2v5ecg	154	5	homologues	homologue	NNS
cord-285091-2i2v5ecg	154	6	of	of	IN
cord-285091-2i2v5ecg	154	7	eukaryotic	eukaryotic	JJ
cord-285091-2i2v5ecg	154	8	ones	one	NNS
cord-285091-2i2v5ecg	154	9	,	,	,
cord-285091-2i2v5ecg	154	10	the	the	DT
cord-285091-2i2v5ecg	154	11	authors	author	NNS
cord-285091-2i2v5ecg	154	12	of	of	IN
cord-285091-2i2v5ecg	154	13	the	the	DT
cord-285091-2i2v5ecg	154	14	analysis	analysis	NN
cord-285091-2i2v5ecg	154	15	suggested	suggest	VBD
cord-285091-2i2v5ecg	154	16	that	that	IN
cord-285091-2i2v5ecg	154	17	they	-PRON-	PRP
cord-285091-2i2v5ecg	154	18	might	may	MD
cord-285091-2i2v5ecg	154	19	inhibit	inhibit	VB
cord-285091-2i2v5ecg	154	20	the	the	DT
cord-285091-2i2v5ecg	154	21	cysteine	cysteine	NN
cord-285091-2i2v5ecg	154	22	proteases	protease	NNS
cord-285091-2i2v5ecg	154	23	of	of	IN
cord-285091-2i2v5ecg	154	24	their	-PRON-	PRP$
cord-285091-2i2v5ecg	154	25	eukaryotic	eukaryotic	JJ
cord-285091-2i2v5ecg	154	26	hosts	host	NNS
cord-285091-2i2v5ecg	154	27	[	[	-LRB-
cord-285091-2i2v5ecg	154	28	107	107	CD
cord-285091-2i2v5ecg	154	29	]	]	-RRB-
cord-285091-2i2v5ecg	154	30	.	.	.
cord-285091-2i2v5ecg	155	1	Bacterial	bacterial	JJ
cord-285091-2i2v5ecg	155	2	pathogen	pathogen	NN
cord-285091-2i2v5ecg	155	3	Streptococcus	streptococcus	NN
cord-285091-2i2v5ecg	155	4	pyogenes	pyogene	NNS
cord-285091-2i2v5ecg	155	5	secretes	secrete	VBZ
cord-285091-2i2v5ecg	155	6	a	a	DT
cord-285091-2i2v5ecg	155	7	highly	highly	RB
cord-285091-2i2v5ecg	155	8	specific	specific	JJ
cord-285091-2i2v5ecg	155	9	protease	protease	NN
cord-285091-2i2v5ecg	155	10	,	,	,
cord-285091-2i2v5ecg	155	11	called	call	VBN
cord-285091-2i2v5ecg	155	12	Ides	Ides	NNP
cord-285091-2i2v5ecg	155	13	,	,	,
cord-285091-2i2v5ecg	155	14	which	which	WDT
cord-285091-2i2v5ecg	155	15	cleaves	cleave	VBZ
cord-285091-2i2v5ecg	155	16	only	only	RB
cord-285091-2i2v5ecg	155	17	immunoglobulin	immunoglobulin	NN
cord-285091-2i2v5ecg	155	18	IgG	IgG	NNP
cord-285091-2i2v5ecg	155	19	[	[	-LRB-
cord-285091-2i2v5ecg	155	20	108	108	CD
cord-285091-2i2v5ecg	155	21	,	,	,
cord-285091-2i2v5ecg	155	22	109	109	CD
cord-285091-2i2v5ecg	155	23	]	]	-RRB-
cord-285091-2i2v5ecg	155	24	.	.	.
cord-285091-2i2v5ecg	156	1	Contrary	contrary	JJ
cord-285091-2i2v5ecg	156	2	to	to	IN
cord-285091-2i2v5ecg	156	3	the	the	DT
cord-285091-2i2v5ecg	156	4	expectations	expectation	NNS
cord-285091-2i2v5ecg	156	5	,	,	,
cord-285091-2i2v5ecg	156	6	IdeS	IdeS	NNP
cord-285091-2i2v5ecg	156	7	activity	activity	NN
cord-285091-2i2v5ecg	156	8	is	be	VBZ
cord-285091-2i2v5ecg	156	9	not	not	RB
cord-285091-2i2v5ecg	156	10	inhibited	inhibit	VBN
cord-285091-2i2v5ecg	156	11	by	by	IN
cord-285091-2i2v5ecg	156	12	host	host	NN
cord-285091-2i2v5ecg	156	13	protease	protease	NN
cord-285091-2i2v5ecg	156	14	inhibitors	inhibitor	NNS
cord-285091-2i2v5ecg	156	15	cystatin	cystatin	NNP
cord-285091-2i2v5ecg	156	16	C	C	NNP
cord-285091-2i2v5ecg	156	17	,	,	,
cord-285091-2i2v5ecg	156	18	instead	instead	RB
cord-285091-2i2v5ecg	156	19	the	the	DT
cord-285091-2i2v5ecg	156	20	protease	protease	NN
cord-285091-2i2v5ecg	156	21	activity	activity	NN
cord-285091-2i2v5ecg	156	22	was	be	VBD
cord-285091-2i2v5ecg	156	23	markedly	markedly	RB
cord-285091-2i2v5ecg	156	24	stimulated	stimulate	VBN
cord-285091-2i2v5ecg	156	25	.	.	.
cord-285091-2i2v5ecg	157	1	Kinetic	kinetic	JJ
cord-285091-2i2v5ecg	157	2	studies	study	NNS
cord-285091-2i2v5ecg	157	3	revealed	reveal	VBD
cord-285091-2i2v5ecg	157	4	that	that	IN
cord-285091-2i2v5ecg	157	5	the	the	DT
cord-285091-2i2v5ecg	157	6	human	human	JJ
cord-285091-2i2v5ecg	157	7	cystatin	cystatin	NNP
cord-285091-2i2v5ecg	157	8	C	C	NNP
cord-285091-2i2v5ecg	157	9	efficiently	efficiently	RB
cord-285091-2i2v5ecg	157	10	accelerated	accelerate	VBD
cord-285091-2i2v5ecg	157	11	the	the	DT
cord-285091-2i2v5ecg	157	12	enzymatic	enzymatic	JJ
cord-285091-2i2v5ecg	157	13	velocity	velocity	NN
cord-285091-2i2v5ecg	157	14	of	of	IN
cord-285091-2i2v5ecg	157	15	the	the	DT
cord-285091-2i2v5ecg	157	16	pathogen	pathogen	NN
cord-285091-2i2v5ecg	157	17	cysteine	cysteine	NN
cord-285091-2i2v5ecg	157	18	protease	protease	NN
cord-285091-2i2v5ecg	157	19	IdeS	IdeS	NNP
cord-285091-2i2v5ecg	157	20	and	and	CC
cord-285091-2i2v5ecg	157	21	thus	thus	RB
cord-285091-2i2v5ecg	157	22	functions	function	VBZ
cord-285091-2i2v5ecg	157	23	as	as	IN
cord-285091-2i2v5ecg	157	24	a	a	DT
cord-285091-2i2v5ecg	157	25	facultative	facultative	JJ
cord-285091-2i2v5ecg	157	26	cofactor	cofactor	NN
cord-285091-2i2v5ecg	157	27	for	for	IN
cord-285091-2i2v5ecg	157	28	this	this	DT
cord-285091-2i2v5ecg	157	29	bacterial	bacterial	JJ
cord-285091-2i2v5ecg	157	30	protease	protease	NN
cord-285091-2i2v5ecg	157	31	[	[	-LRB-
cord-285091-2i2v5ecg	157	32	110	110	CD
cord-285091-2i2v5ecg	157	33	]	]	-RRB-
cord-285091-2i2v5ecg	157	34	.	.	.
cord-285091-2i2v5ecg	158	1	Therefore	therefore	RB
cord-285091-2i2v5ecg	158	2	more	more	JJR
cord-285091-2i2v5ecg	158	3	experimental	experimental	JJ
cord-285091-2i2v5ecg	158	4	data	datum	NNS
cord-285091-2i2v5ecg	158	5	will	will	MD
cord-285091-2i2v5ecg	158	6	be	be	VB
cord-285091-2i2v5ecg	158	7	needed	need	VBN
cord-285091-2i2v5ecg	158	8	before	before	IN
cord-285091-2i2v5ecg	158	9	we	-PRON-	PRP
cord-285091-2i2v5ecg	158	10	can	can	MD
cord-285091-2i2v5ecg	158	11	make	make	VB
cord-285091-2i2v5ecg	158	12	conclusions	conclusion	NNS
cord-285091-2i2v5ecg	158	13	regarding	regard	VBG
cord-285091-2i2v5ecg	158	14	the	the	DT
cord-285091-2i2v5ecg	158	15	role	role	NN
cord-285091-2i2v5ecg	158	16	of	of	IN
cord-285091-2i2v5ecg	158	17	bacterial	bacterial	JJ
cord-285091-2i2v5ecg	158	18	cystatins	cystatin	NNS
cord-285091-2i2v5ecg	158	19	.	.	.
cord-285091-2i2v5ecg	159	1	Recently	recently	RB
cord-285091-2i2v5ecg	159	2	,	,	,
cord-285091-2i2v5ecg	159	3	it	-PRON-	PRP
cord-285091-2i2v5ecg	159	4	was	be	VBD
cord-285091-2i2v5ecg	159	5	reported	report	VBN
cord-285091-2i2v5ecg	159	6	that	that	IN
cord-285091-2i2v5ecg	159	7	gram	gram	JJ
cord-285091-2i2v5ecg	159	8	negative	negative	JJ
cord-285091-2i2v5ecg	159	9	pathogen	pathogen	NN
cord-285091-2i2v5ecg	159	10	Anaplasma	Anaplasma	NNP
cord-285091-2i2v5ecg	159	11	phagocytophilum	phagocytophilum	NN
cord-285091-2i2v5ecg	159	12	,	,	,
cord-285091-2i2v5ecg	159	13	which	which	WDT
cord-285091-2i2v5ecg	159	14	causes	cause	VBZ
cord-285091-2i2v5ecg	159	15	human	human	JJ
cord-285091-2i2v5ecg	159	16	granulocytic	granulocytic	JJ
cord-285091-2i2v5ecg	159	17	anaplasmosis	anaplasmosis	NN
cord-285091-2i2v5ecg	159	18	and	and	CC
cord-285091-2i2v5ecg	159	19	is	be	VBZ
cord-285091-2i2v5ecg	159	20	harboured	harbour	VBN
cord-285091-2i2v5ecg	159	21	within	within	IN
cord-285091-2i2v5ecg	159	22	neutrophils	neutrophil	NNS
cord-285091-2i2v5ecg	159	23	,	,	,
cord-285091-2i2v5ecg	159	24	upregulates	upregulate	VBZ
cord-285091-2i2v5ecg	159	25	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	159	26	L	L	NNP
cord-285091-2i2v5ecg	159	27	expression	expression	NN
cord-285091-2i2v5ecg	159	28	in	in	IN
cord-285091-2i2v5ecg	159	29	the	the	DT
cord-285091-2i2v5ecg	159	30	nucleus	nucleus	NN
cord-285091-2i2v5ecg	159	31	and	and	CC
cord-285091-2i2v5ecg	159	32	leads	lead	VBZ
cord-285091-2i2v5ecg	159	33	to	to	IN
cord-285091-2i2v5ecg	159	34	enhanced	enhance	VBN
cord-285091-2i2v5ecg	159	35	CUX1	CUX1	NNP
cord-285091-2i2v5ecg	159	36	cleavage	cleavage	NN
cord-285091-2i2v5ecg	159	37	and	and	CC
cord-285091-2i2v5ecg	159	38	the	the	DT
cord-285091-2i2v5ecg	159	39	repression	repression	NN
cord-285091-2i2v5ecg	159	40	of	of	IN
cord-285091-2i2v5ecg	159	41	CUX1regulated	cux1regulated	JJ
cord-285091-2i2v5ecg	159	42	essential	essential	JJ
cord-285091-2i2v5ecg	159	43	genes	gene	NNS
cord-285091-2i2v5ecg	159	44	for	for	IN
cord-285091-2i2v5ecg	159	45	effective	effective	JJ
cord-285091-2i2v5ecg	159	46	neutrophil	neutrophil	NN
cord-285091-2i2v5ecg	159	47	function	function	NN
cord-285091-2i2v5ecg	159	48	[	[	-LRB-
cord-285091-2i2v5ecg	159	49	111	111	CD
cord-285091-2i2v5ecg	159	50	]	]	-RRB-
cord-285091-2i2v5ecg	159	51	.	.	.
cord-285091-2i2v5ecg	160	1	The	the	DT
cord-285091-2i2v5ecg	160	2	ways	way	NNS
cord-285091-2i2v5ecg	160	3	in	in	IN
cord-285091-2i2v5ecg	160	4	which	which	WDT
cord-285091-2i2v5ecg	160	5	viruses	virus	NNS
cord-285091-2i2v5ecg	160	6	entry	entry	VBP
cord-285091-2i2v5ecg	160	7	the	the	DT
cord-285091-2i2v5ecg	160	8	host	host	NN
cord-285091-2i2v5ecg	160	9	cells	cell	NNS
cord-285091-2i2v5ecg	160	10	are	be	VBP
cord-285091-2i2v5ecg	160	11	largely	largely	RB
cord-285091-2i2v5ecg	160	12	defined	define	VBN
cord-285091-2i2v5ecg	160	13	by	by	IN
cord-285091-2i2v5ecg	160	14	the	the	DT
cord-285091-2i2v5ecg	160	15	interactions	interaction	NNS
cord-285091-2i2v5ecg	160	16	between	between	IN
cord-285091-2i2v5ecg	160	17	virus	virus	NN
cord-285091-2i2v5ecg	160	18	particles	particle	NNS
cord-285091-2i2v5ecg	160	19	and	and	CC
cord-285091-2i2v5ecg	160	20	their	-PRON-	PRP$
cord-285091-2i2v5ecg	160	21	receptors	receptor	NNS
cord-285091-2i2v5ecg	160	22	at	at	IN
cord-285091-2i2v5ecg	160	23	the	the	DT
cord-285091-2i2v5ecg	160	24	host	host	NN
cord-285091-2i2v5ecg	160	25	cell	cell	NN
cord-285091-2i2v5ecg	160	26	surface	surface	NN
cord-285091-2i2v5ecg	160	27	[	[	-LRB-
cord-285091-2i2v5ecg	160	28	112	112	CD
cord-285091-2i2v5ecg	160	29	]	]	-RRB-
cord-285091-2i2v5ecg	160	30	.	.	.
cord-285091-2i2v5ecg	161	1	Enveloped	envelop	VBN
cord-285091-2i2v5ecg	161	2	viruses	virus	NNS
cord-285091-2i2v5ecg	161	3	,	,	,
cord-285091-2i2v5ecg	161	4	such	such	JJ
cord-285091-2i2v5ecg	161	5	as	as	IN
cord-285091-2i2v5ecg	161	6	orthomyxoviruses	orthomyxoviruses	NNP
cord-285091-2i2v5ecg	161	7	[	[	-LRB-
cord-285091-2i2v5ecg	161	8	113	113	CD
cord-285091-2i2v5ecg	161	9	,	,	,
cord-285091-2i2v5ecg	161	10	114	114	CD
cord-285091-2i2v5ecg	161	11	]	]	-RRB-
cord-285091-2i2v5ecg	161	12	,	,	,
cord-285091-2i2v5ecg	161	13	paramyxoviruses	paramyxovirus	NNS
cord-285091-2i2v5ecg	161	14	[	[	-LRB-
cord-285091-2i2v5ecg	161	15	115	115	CD
cord-285091-2i2v5ecg	161	16	]	]	-RRB-
cord-285091-2i2v5ecg	161	17	and	and	CC
cord-285091-2i2v5ecg	161	18	retroviruses	retrovirus	NNS
cord-285091-2i2v5ecg	161	19	[	[	-LRB-
cord-285091-2i2v5ecg	161	20	116	116	CD
cord-285091-2i2v5ecg	161	21	,	,	,
cord-285091-2i2v5ecg	161	22	117	117	CD
cord-285091-2i2v5ecg	161	23	]	]	-RRB-
cord-285091-2i2v5ecg	161	24	encode	encode	VBP
cord-285091-2i2v5ecg	161	25	proteins	protein	NNS
cord-285091-2i2v5ecg	161	26	that	that	WDT
cord-285091-2i2v5ecg	161	27	mediate	mediate	VBP
cord-285091-2i2v5ecg	161	28	fusion	fusion	NN
cord-285091-2i2v5ecg	161	29	of	of	IN
cord-285091-2i2v5ecg	161	30	the	the	DT
cord-285091-2i2v5ecg	161	31	viral	viral	JJ
cord-285091-2i2v5ecg	161	32	envelope	envelope	NN
cord-285091-2i2v5ecg	161	33	with	with	IN
cord-285091-2i2v5ecg	161	34	target	target	NN
cord-285091-2i2v5ecg	161	35	cell	cell	NN
cord-285091-2i2v5ecg	161	36	membranes	membrane	NNS
cord-285091-2i2v5ecg	161	37	,	,	,
cord-285091-2i2v5ecg	161	38	thus	thus	RB
cord-285091-2i2v5ecg	161	39	facilitating	facilitate	VBG
cord-285091-2i2v5ecg	161	40	viral	viral	JJ
cord-285091-2i2v5ecg	161	41	cell	cell	NN
cord-285091-2i2v5ecg	161	42	entry	entry	NN
cord-285091-2i2v5ecg	161	43	.	.	.
cord-285091-2i2v5ecg	162	1	The	the	DT
cord-285091-2i2v5ecg	162	2	majority	majority	NN
cord-285091-2i2v5ecg	162	3	of	of	IN
cord-285091-2i2v5ecg	162	4	viruses	virus	NNS
cord-285091-2i2v5ecg	162	5	are	be	VBP
cord-285091-2i2v5ecg	162	6	internalized	internalize	VBN
cord-285091-2i2v5ecg	162	7	by	by	IN
cord-285091-2i2v5ecg	162	8	endocytosis	endocytosis	NN
cord-285091-2i2v5ecg	162	9	and	and	CC
cord-285091-2i2v5ecg	162	10	delivered	deliver	VBN
cord-285091-2i2v5ecg	162	11	to	to	IN
cord-285091-2i2v5ecg	162	12	the	the	DT
cord-285091-2i2v5ecg	162	13	endosomes	endosome	NNS
cord-285091-2i2v5ecg	162	14	.	.	.
cord-285091-2i2v5ecg	163	1	In	in	IN
cord-285091-2i2v5ecg	163	2	addition	addition	NN
cord-285091-2i2v5ecg	163	3	to	to	TO
cord-285091-2i2v5ecg	163	4	host	host	VB
cord-285091-2i2v5ecg	163	5	cell	cell	NN
cord-285091-2i2v5ecg	163	6	receptors	receptor	NNS
cord-285091-2i2v5ecg	163	7	,	,	,
cord-285091-2i2v5ecg	163	8	at	at	IN
cord-285091-2i2v5ecg	163	9	least	least	JJS
cord-285091-2i2v5ecg	163	10	in	in	IN
cord-285091-2i2v5ecg	163	11	some	some	DT
cord-285091-2i2v5ecg	163	12	cases	case	NNS
cord-285091-2i2v5ecg	163	13	,	,	,
cord-285091-2i2v5ecg	163	14	endolysosomal	endolysosomal	NNP
cord-285091-2i2v5ecg	163	15	cysteine	cysteine	NN
cord-285091-2i2v5ecg	163	16	cathepsins	cathepsin	NNS
cord-285091-2i2v5ecg	163	17	are	be	VBP
cord-285091-2i2v5ecg	163	18	required	require	VBN
cord-285091-2i2v5ecg	163	19	for	for	IN
cord-285091-2i2v5ecg	163	20	their	-PRON-	PRP$
cord-285091-2i2v5ecg	163	21	transport	transport	NN
cord-285091-2i2v5ecg	163	22	into	into	IN
cord-285091-2i2v5ecg	163	23	the	the	DT
cord-285091-2i2v5ecg	163	24	cytosol	cytosol	NN
cord-285091-2i2v5ecg	163	25	[	[	-LRB-
cord-285091-2i2v5ecg	163	26	118	118	CD
cord-285091-2i2v5ecg	163	27	]	]	-RRB-
cord-285091-2i2v5ecg	163	28	.	.	.
cord-285091-2i2v5ecg	164	1	Filoviruses	filovirus	NNS
cord-285091-2i2v5ecg	164	2	are	be	VBP
cord-285091-2i2v5ecg	164	3	enveloped	envelop	VBN
cord-285091-2i2v5ecg	164	4	,	,	,
cord-285091-2i2v5ecg	164	5	single	single	RB
cord-285091-2i2v5ecg	164	6	-	-	HYPH
cord-285091-2i2v5ecg	164	7	stranded	stranded	JJ
cord-285091-2i2v5ecg	164	8	,	,	,
cord-285091-2i2v5ecg	164	9	negativesense	negativesense	NNP
cord-285091-2i2v5ecg	164	10	RNA	RNA	NNP
cord-285091-2i2v5ecg	164	11	viruses	virus	NNS
cord-285091-2i2v5ecg	164	12	.	.	.
cord-285091-2i2v5ecg	165	1	Infections	infection	NNS
cord-285091-2i2v5ecg	165	2	by	by	IN
cord-285091-2i2v5ecg	165	3	the	the	DT
cord-285091-2i2v5ecg	165	4	Ebola	Ebola	NNP
cord-285091-2i2v5ecg	165	5	and	and	CC
cord-285091-2i2v5ecg	165	6	Marburg	Marburg	NNP
cord-285091-2i2v5ecg	165	7	filoviruses	filovirus	NNS
cord-285091-2i2v5ecg	165	8	cause	cause	VBP
cord-285091-2i2v5ecg	165	9	a	a	DT
cord-285091-2i2v5ecg	165	10	fatal	fatal	JJ
cord-285091-2i2v5ecg	165	11	haemorrhagic	haemorrhagic	JJ
cord-285091-2i2v5ecg	165	12	fever	fever	NN
cord-285091-2i2v5ecg	165	13	in	in	IN
cord-285091-2i2v5ecg	165	14	humans	human	NNS
cord-285091-2i2v5ecg	165	15	and	and	CC
cord-285091-2i2v5ecg	165	16	non	non	JJ
cord-285091-2i2v5ecg	165	17	human	human	JJ
cord-285091-2i2v5ecg	165	18	primates	primate	NNS
cord-285091-2i2v5ecg	165	19	,	,	,
cord-285091-2i2v5ecg	165	20	for	for	IN
cord-285091-2i2v5ecg	165	21	which	which	WDT
cord-285091-2i2v5ecg	165	22	no	no	DT
cord-285091-2i2v5ecg	165	23	approved	approve	VBN
cord-285091-2i2v5ecg	165	24	antivirals	antiviral	NNS
cord-285091-2i2v5ecg	165	25	are	be	VBP
cord-285091-2i2v5ecg	165	26	available	available	JJ
cord-285091-2i2v5ecg	165	27	[	[	-LRB-
cord-285091-2i2v5ecg	165	28	119	119	CD
cord-285091-2i2v5ecg	165	29	]	]	-RRB-
cord-285091-2i2v5ecg	165	30	.	.	.
cord-285091-2i2v5ecg	166	1	It	-PRON-	PRP
cord-285091-2i2v5ecg	166	2	has	have	VBZ
cord-285091-2i2v5ecg	166	3	been	be	VBN
cord-285091-2i2v5ecg	166	4	shown	show	VBN
cord-285091-2i2v5ecg	166	5	that	that	IN
cord-285091-2i2v5ecg	166	6	the	the	DT
cord-285091-2i2v5ecg	166	7	endolysosomal	endolysosomal	JJ
cord-285091-2i2v5ecg	166	8	processing	processing	NN
cord-285091-2i2v5ecg	166	9	by	by	IN
cord-285091-2i2v5ecg	166	10	cathepsins	cathepsin	NNS
cord-285091-2i2v5ecg	166	11	B	B	NNP
cord-285091-2i2v5ecg	166	12	and	and	CC
cord-285091-2i2v5ecg	166	13	L	L	NNP
cord-285091-2i2v5ecg	166	14	of	of	IN
cord-285091-2i2v5ecg	166	15	the	the	DT
cord-285091-2i2v5ecg	166	16	Ebola	Ebola	NNP
cord-285091-2i2v5ecg	166	17	virus	virus	NN
cord-285091-2i2v5ecg	166	18	glycoprotein	glycoprotein	NN
cord-285091-2i2v5ecg	166	19	is	be	VBZ
cord-285091-2i2v5ecg	166	20	essential	essential	JJ
cord-285091-2i2v5ecg	166	21	for	for	IN
cord-285091-2i2v5ecg	166	22	the	the	DT
cord-285091-2i2v5ecg	166	23	delivery	delivery	NN
cord-285091-2i2v5ecg	166	24	of	of	IN
cord-285091-2i2v5ecg	166	25	viral	viral	JJ
cord-285091-2i2v5ecg	166	26	material	material	NN
cord-285091-2i2v5ecg	166	27	into	into	IN
cord-285091-2i2v5ecg	166	28	the	the	DT
cord-285091-2i2v5ecg	166	29	cytosol	cytosol	NN
cord-285091-2i2v5ecg	166	30	[	[	-LRB-
cord-285091-2i2v5ecg	166	31	118	118	CD
cord-285091-2i2v5ecg	166	32	]	]	-RRB-
cord-285091-2i2v5ecg	166	33	.	.	.
cord-285091-2i2v5ecg	167	1	Ebola	Ebola	NNP
cord-285091-2i2v5ecg	167	2	and	and	CC
cord-285091-2i2v5ecg	167	3	Marburg	Marburg	NNP
cord-285091-2i2v5ecg	167	4	entry	entry	NN
cord-285091-2i2v5ecg	167	5	into	into	IN
cord-285091-2i2v5ecg	167	6	the	the	DT
cord-285091-2i2v5ecg	167	7	host	host	NN
cord-285091-2i2v5ecg	167	8	cell	cell	NN
cord-285091-2i2v5ecg	167	9	is	be	VBZ
cord-285091-2i2v5ecg	167	10	mediated	mediate	VBN
cord-285091-2i2v5ecg	167	11	by	by	IN
cord-285091-2i2v5ecg	167	12	the	the	DT
cord-285091-2i2v5ecg	167	13	viral	viral	JJ
cord-285091-2i2v5ecg	167	14	spike	spike	NN
cord-285091-2i2v5ecg	167	15	glycoprotein	glycoprotein	NN
cord-285091-2i2v5ecg	167	16	(	(	-LRB-
cord-285091-2i2v5ecg	167	17	GP	GP	NNP
cord-285091-2i2v5ecg	167	18	)	)	-RRB-
cord-285091-2i2v5ecg	167	19	,	,	,
cord-285091-2i2v5ecg	167	20	which	which	WDT
cord-285091-2i2v5ecg	167	21	attaches	attach	VBZ
cord-285091-2i2v5ecg	167	22	viral	viral	JJ
cord-285091-2i2v5ecg	167	23	particles	particle	NNS
cord-285091-2i2v5ecg	167	24	to	to	IN
cord-285091-2i2v5ecg	167	25	the	the	DT
cord-285091-2i2v5ecg	167	26	cell	cell	NN
cord-285091-2i2v5ecg	167	27	surface	surface	NN
cord-285091-2i2v5ecg	167	28	[	[	-LRB-
cord-285091-2i2v5ecg	167	29	120	120	CD
cord-285091-2i2v5ecg	167	30	,	,	,
cord-285091-2i2v5ecg	167	31	121	121	CD
cord-285091-2i2v5ecg	167	32	]	]	-RRB-
cord-285091-2i2v5ecg	167	33	.	.	.
cord-285091-2i2v5ecg	168	1	Ebola	Ebola	NNP
cord-285091-2i2v5ecg	168	2	virus	virus	NN
cord-285091-2i2v5ecg	168	3	GP	gp	NN
cord-285091-2i2v5ecg	168	4	is	be	VBZ
cord-285091-2i2v5ecg	168	5	synthesized	synthesize	VBN
cord-285091-2i2v5ecg	168	6	as	as	IN
cord-285091-2i2v5ecg	168	7	a	a	DT
cord-285091-2i2v5ecg	168	8	single	single	JJ
cord-285091-2i2v5ecg	168	9	polypeptide	polypeptide	NN
cord-285091-2i2v5ecg	168	10	chain	chain	NN
cord-285091-2i2v5ecg	168	11	that	that	WDT
cord-285091-2i2v5ecg	168	12	is	be	VBZ
cord-285091-2i2v5ecg	168	13	cleaved	cleave	VBN
cord-285091-2i2v5ecg	168	14	in	in	IN
cord-285091-2i2v5ecg	168	15	the	the	DT
cord-285091-2i2v5ecg	168	16	Golgi	Golgi	NNP
cord-285091-2i2v5ecg	168	17	into	into	IN
cord-285091-2i2v5ecg	168	18	its	-PRON-	PRP$
cord-285091-2i2v5ecg	168	19	receptor	receptor	NN
cord-285091-2i2v5ecg	168	20	-	-	HYPH
cord-285091-2i2v5ecg	168	21	binding	binding	NN
cord-285091-2i2v5ecg	168	22	(	(	-LRB-
cord-285091-2i2v5ecg	168	23	GP1	GP1	NNP
cord-285091-2i2v5ecg	168	24	)	)	-RRB-
cord-285091-2i2v5ecg	168	25	and	and	CC
cord-285091-2i2v5ecg	168	26	fusion	fusion	NN
cord-285091-2i2v5ecg	168	27	(	(	-LRB-
cord-285091-2i2v5ecg	168	28	GP2	GP2	NNP
cord-285091-2i2v5ecg	168	29	)	)	-RRB-
cord-285091-2i2v5ecg	168	30	subunits	subunit	NNS
cord-285091-2i2v5ecg	168	31	,	,	,
cord-285091-2i2v5ecg	168	32	which	which	WDT
cord-285091-2i2v5ecg	168	33	remain	remain	VBP
cord-285091-2i2v5ecg	168	34	together	together	RB
cord-285091-2i2v5ecg	168	35	through	through	IN
cord-285091-2i2v5ecg	168	36	noncovalent	noncovalent	JJ
cord-285091-2i2v5ecg	168	37	interactions	interaction	NNS
cord-285091-2i2v5ecg	168	38	and	and	CC
cord-285091-2i2v5ecg	168	39	through	through	IN
cord-285091-2i2v5ecg	168	40	a	a	DT
cord-285091-2i2v5ecg	168	41	disulphide	disulphide	JJ
cord-285091-2i2v5ecg	168	42	bond	bond	NN
cord-285091-2i2v5ecg	168	43	.	.	.
cord-285091-2i2v5ecg	169	1	Three	three	CD
cord-285091-2i2v5ecg	169	2	GP1-S	GP1-S	NNP
cord-285091-2i2v5ecg	169	3	-	-	HYPH
cord-285091-2i2v5ecg	169	4	S	S	NNP
cord-285091-2i2v5ecg	169	5	-	-	HYPH
cord-285091-2i2v5ecg	169	6	GP2	GP2	NNP
cord-285091-2i2v5ecg	169	7	units	unit	NNS
cord-285091-2i2v5ecg	169	8	come	come	VBP
cord-285091-2i2v5ecg	169	9	together	together	RB
cord-285091-2i2v5ecg	169	10	to	to	TO
cord-285091-2i2v5ecg	169	11	form	form	VB
cord-285091-2i2v5ecg	169	12	the	the	DT
cord-285091-2i2v5ecg	169	13	homotrimer	homotrimer	NN
cord-285091-2i2v5ecg	169	14	that	that	WDT
cord-285091-2i2v5ecg	169	15	protrudes	protrude	VBZ
cord-285091-2i2v5ecg	169	16	from	from	IN
cord-285091-2i2v5ecg	169	17	the	the	DT
cord-285091-2i2v5ecg	169	18	virion	virion	NN
cord-285091-2i2v5ecg	169	19	surface	surface	NN
cord-285091-2i2v5ecg	169	20	[	[	-LRB-
cord-285091-2i2v5ecg	169	21	120	120	CD
cord-285091-2i2v5ecg	169	22	,	,	,
cord-285091-2i2v5ecg	169	23	121	121	CD
cord-285091-2i2v5ecg	169	24	]	]	-RRB-
cord-285091-2i2v5ecg	169	25	.	.	.
cord-285091-2i2v5ecg	170	1	It	-PRON-	PRP
cord-285091-2i2v5ecg	170	2	was	be	VBD
cord-285091-2i2v5ecg	170	3	reported	report	VBN
cord-285091-2i2v5ecg	170	4	that	that	IN
cord-285091-2i2v5ecg	170	5	the	the	DT
cord-285091-2i2v5ecg	170	6	GP1	gp1	NN
cord-285091-2i2v5ecg	170	7	cleavage	cleavage	NN
cord-285091-2i2v5ecg	170	8	is	be	VBZ
cord-285091-2i2v5ecg	170	9	a	a	DT
cord-285091-2i2v5ecg	170	10	two	two	CD
cord-285091-2i2v5ecg	170	11	-	-	HYPH
cord-285091-2i2v5ecg	170	12	step	step	NN
cord-285091-2i2v5ecg	170	13	event	event	NN
cord-285091-2i2v5ecg	170	14	:	:	:
cord-285091-2i2v5ecg	170	15	first	first	JJ
cord-285091-2i2v5ecg	170	16	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	170	17	L	l	NN
cord-285091-2i2v5ecg	170	18	cleaved	cleave	VBD
cord-285091-2i2v5ecg	170	19	GP1	GP1	NNP
cord-285091-2i2v5ecg	170	20	into	into	IN
cord-285091-2i2v5ecg	170	21	20	20	CD
cord-285091-2i2v5ecg	170	22	kDa	kDa	NNS
cord-285091-2i2v5ecg	170	23	fragment	fragment	NN
cord-285091-2i2v5ecg	170	24	and	and	CC
cord-285091-2i2v5ecg	170	25	after	after	IN
cord-285091-2i2v5ecg	170	26	the	the	DT
cord-285091-2i2v5ecg	170	27	cleavage	cleavage	NN
cord-285091-2i2v5ecg	170	28	with	with	IN
cord-285091-2i2v5ecg	170	29	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	170	30	B	B	NNP
cord-285091-2i2v5ecg	170	31	19	19	CD
cord-285091-2i2v5ecg	170	32	kDa	kDa	NNS
cord-285091-2i2v5ecg	170	33	fragment	fragment	NN
cord-285091-2i2v5ecg	170	34	is	be	VBZ
cord-285091-2i2v5ecg	170	35	generated	generate	VBN
cord-285091-2i2v5ecg	170	36	[	[	-LRB-
cord-285091-2i2v5ecg	170	37	122	122	CD
cord-285091-2i2v5ecg	170	38	]	]	-RRB-
cord-285091-2i2v5ecg	170	39	.	.	.
cord-285091-2i2v5ecg	171	1	The	the	DT
cord-285091-2i2v5ecg	171	2	translocation	translocation	NN
cord-285091-2i2v5ecg	171	3	of	of	IN
cord-285091-2i2v5ecg	171	4	pseudovirions	pseudovirion	NNS
cord-285091-2i2v5ecg	171	5	bearing	bear	VBG
cord-285091-2i2v5ecg	171	6	20	20	CD
cord-285091-2i2v5ecg	171	7	kDa	kDa	NNS
cord-285091-2i2v5ecg	171	8	GP	GP	NNP
cord-285091-2i2v5ecg	171	9	into	into	IN
cord-285091-2i2v5ecg	171	10	cytoplasm	cytoplasm	NN
cord-285091-2i2v5ecg	171	11	was	be	VBD
cord-285091-2i2v5ecg	171	12	strongly	strongly	RB
cord-285091-2i2v5ecg	171	13	inhibited	inhibit	VBN
cord-285091-2i2v5ecg	171	14	by	by	IN
cord-285091-2i2v5ecg	171	15	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	171	16	B	B	NNP
cord-285091-2i2v5ecg	171	17	inhibitors	inhibitor	NNS
cord-285091-2i2v5ecg	171	18	,	,	,
cord-285091-2i2v5ecg	171	19	while	while	IN
cord-285091-2i2v5ecg	171	20	the	the	DT
cord-285091-2i2v5ecg	171	21	entry	entry	NN
cord-285091-2i2v5ecg	171	22	of	of	IN
cord-285091-2i2v5ecg	171	23	pseudovirions	pseudovirion	NNS
cord-285091-2i2v5ecg	171	24	bearing	bear	VBG
cord-285091-2i2v5ecg	171	25	19	19	CD
cord-285091-2i2v5ecg	171	26	kDa	kDa	NNPS
cord-285091-2i2v5ecg	171	27	GP1	GP1	NNP
cord-285091-2i2v5ecg	171	28	was	be	VBD
cord-285091-2i2v5ecg	171	29	not	not	RB
cord-285091-2i2v5ecg	171	30	[	[	-LRB-
cord-285091-2i2v5ecg	171	31	123	123	CD
cord-285091-2i2v5ecg	171	32	,	,	,
cord-285091-2i2v5ecg	171	33	124	124	CD
cord-285091-2i2v5ecg	171	34	]	]	-RRB-
cord-285091-2i2v5ecg	171	35	.	.	.
cord-285091-2i2v5ecg	172	1	A	a	DT
cord-285091-2i2v5ecg	172	2	recent	recent	JJ
cord-285091-2i2v5ecg	172	3	study	study	NN
cord-285091-2i2v5ecg	172	4	confirmed	confirm	VBD
cord-285091-2i2v5ecg	172	5	that	that	IN
cord-285091-2i2v5ecg	172	6	GP	GP	NNP
cord-285091-2i2v5ecg	172	7	cleavage	cleavage	NN
cord-285091-2i2v5ecg	172	8	by	by	IN
cord-285091-2i2v5ecg	172	9	endosomal	endosomal	NNP
cord-285091-2i2v5ecg	172	10	cathepsins	cathepsin	NNS
cord-285091-2i2v5ecg	172	11	was	be	VBD
cord-285091-2i2v5ecg	172	12	essential	essential	JJ
cord-285091-2i2v5ecg	172	13	to	to	TO
cord-285091-2i2v5ecg	172	14	reveal	reveal	VB
cord-285091-2i2v5ecg	172	15	a	a	DT
cord-285091-2i2v5ecg	172	16	putative	putative	JJ
cord-285091-2i2v5ecg	172	17	binding	binding	NN
cord-285091-2i2v5ecg	172	18	domain	domain	NN
cord-285091-2i2v5ecg	172	19	for	for	IN
cord-285091-2i2v5ecg	172	20	the	the	DT
cord-285091-2i2v5ecg	172	21	endolysosomal	endolysosomal	JJ
cord-285091-2i2v5ecg	172	22	cholesterol	cholesterol	NN
cord-285091-2i2v5ecg	172	23	transporter	transporter	NN
cord-285091-2i2v5ecg	172	24	Niemann	Niemann	NNP
cord-285091-2i2v5ecg	172	25	-	-	HYPH
cord-285091-2i2v5ecg	172	26	Pick	Pick	NNP
cord-285091-2i2v5ecg	172	27	C1	C1	NNP
cord-285091-2i2v5ecg	172	28	(	(	-LRB-
cord-285091-2i2v5ecg	172	29	NPC1	NPC1	NNP
cord-285091-2i2v5ecg	172	30	)	)	-RRB-
cord-285091-2i2v5ecg	172	31	[	[	-LRB-
cord-285091-2i2v5ecg	172	32	125	125	CD
cord-285091-2i2v5ecg	172	33	]	]	-RRB-
cord-285091-2i2v5ecg	172	34	.	.	.
cord-285091-2i2v5ecg	173	1	Lack	lack	NN
cord-285091-2i2v5ecg	173	2	of	of	IN
cord-285091-2i2v5ecg	173	3	NPC1	NPC1	NNP
cord-285091-2i2v5ecg	173	4	on	on	IN
cord-285091-2i2v5ecg	173	5	target	target	NN
cord-285091-2i2v5ecg	173	6	cells	cell	NNS
cord-285091-2i2v5ecg	173	7	prevented	prevent	VBD
cord-285091-2i2v5ecg	173	8	Ebola	Ebola	NNP
cord-285091-2i2v5ecg	173	9	virus	virus	NN
cord-285091-2i2v5ecg	173	10	glycoprotein	glycoprotein	NN
cord-285091-2i2v5ecg	173	11	-	-	HYPH
cord-285091-2i2v5ecg	173	12	dependent	dependent	JJ
cord-285091-2i2v5ecg	173	13	fusion	fusion	NN
cord-285091-2i2v5ecg	173	14	[	[	-LRB-
cord-285091-2i2v5ecg	173	15	126	126	CD
cord-285091-2i2v5ecg	173	16	]	]	-RRB-
cord-285091-2i2v5ecg	173	17	.	.	.
cord-285091-2i2v5ecg	174	1	Furthermore	furthermore	RB
cord-285091-2i2v5ecg	174	2	,	,	,
cord-285091-2i2v5ecg	174	3	it	-PRON-	PRP
cord-285091-2i2v5ecg	174	4	was	be	VBD
cord-285091-2i2v5ecg	174	5	reported	report	VBN
cord-285091-2i2v5ecg	174	6	that	that	IN
cord-285091-2i2v5ecg	174	7	the	the	DT
cord-285091-2i2v5ecg	174	8	virulence	virulence	NN
cord-285091-2i2v5ecg	174	9	of	of	IN
cord-285091-2i2v5ecg	174	10	only	only	RB
cord-285091-2i2v5ecg	174	11	some	some	DT
cord-285091-2i2v5ecg	174	12	of	of	IN
cord-285091-2i2v5ecg	174	13	the	the	DT
cord-285091-2i2v5ecg	174	14	Ebola	Ebola	NNP
cord-285091-2i2v5ecg	174	15	virus	virus	NN
cord-285091-2i2v5ecg	174	16	species	species	NN
cord-285091-2i2v5ecg	174	17	is	be	VBZ
cord-285091-2i2v5ecg	174	18	strongly	strongly	RB
cord-285091-2i2v5ecg	174	19	dependent	dependent	JJ
cord-285091-2i2v5ecg	174	20	on	on	IN
cord-285091-2i2v5ecg	174	21	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	174	22	B	b	NN
cord-285091-2i2v5ecg	174	23	[	[	-LRB-
cord-285091-2i2v5ecg	174	24	127	127	CD
cord-285091-2i2v5ecg	174	25	]	]	-RRB-
cord-285091-2i2v5ecg	174	26	.	.	.
cord-285091-2i2v5ecg	175	1	Ebola	Ebola	NNP
cord-285091-2i2v5ecg	175	2	and	and	CC
cord-285091-2i2v5ecg	175	3	Marburg	Marburg	NNP
cord-285091-2i2v5ecg	175	4	viruses	virus	NNS
cord-285091-2i2v5ecg	175	5	are	be	VBP
cord-285091-2i2v5ecg	175	6	highly	highly	RB
cord-285091-2i2v5ecg	175	7	pathogenic	pathogenic	JJ
cord-285091-2i2v5ecg	175	8	with	with	IN
cord-285091-2i2v5ecg	175	9	mortality	mortality	NN
cord-285091-2i2v5ecg	175	10	in	in	IN
cord-285091-2i2v5ecg	175	11	humans	human	NNS
cord-285091-2i2v5ecg	175	12	up	up	IN
cord-285091-2i2v5ecg	175	13	to	to	TO
cord-285091-2i2v5ecg	175	14	90	90	CD
cord-285091-2i2v5ecg	175	15	%	%	NN
cord-285091-2i2v5ecg	175	16	within	within	IN
cord-285091-2i2v5ecg	175	17	days	day	NNS
cord-285091-2i2v5ecg	175	18	of	of	IN
cord-285091-2i2v5ecg	175	19	exposure	exposure	NN
cord-285091-2i2v5ecg	175	20	.	.	.
cord-285091-2i2v5ecg	176	1	While	while	IN
cord-285091-2i2v5ecg	176	2	there	there	EX
cord-285091-2i2v5ecg	176	3	are	be	VBP
cord-285091-2i2v5ecg	176	4	no	no	DT
cord-285091-2i2v5ecg	176	5	FDA	FDA	NNP
cord-285091-2i2v5ecg	176	6	-	-	HYPH
cord-285091-2i2v5ecg	176	7	approved	approve	VBN
cord-285091-2i2v5ecg	176	8	vaccines	vaccine	NNS
cord-285091-2i2v5ecg	176	9	or	or	CC
cord-285091-2i2v5ecg	176	10	post	post	JJ
cord-285091-2i2v5ecg	176	11	-	-	JJ
cord-285091-2i2v5ecg	176	12	exposure	exposure	JJ
cord-285091-2i2v5ecg	176	13	treatment	treatment	NN
cord-285091-2i2v5ecg	176	14	modalities	modality	NNS
cord-285091-2i2v5ecg	176	15	available	available	JJ
cord-285091-2i2v5ecg	176	16	for	for	IN
cord-285091-2i2v5ecg	176	17	preventing	prevent	VBG
cord-285091-2i2v5ecg	176	18	or	or	CC
cord-285091-2i2v5ecg	176	19	managing	manage	VBG
cord-285091-2i2v5ecg	176	20	Ebola	Ebola	NNP
cord-285091-2i2v5ecg	176	21	virus	virus	NN
cord-285091-2i2v5ecg	176	22	or	or	CC
cord-285091-2i2v5ecg	176	23	Marburg	Marburg	NNP
cord-285091-2i2v5ecg	176	24	virus	virus	NN
cord-285091-2i2v5ecg	176	25	infections	infection	NNS
cord-285091-2i2v5ecg	176	26	,	,	,
cord-285091-2i2v5ecg	176	27	several	several	JJ
cord-285091-2i2v5ecg	176	28	promising	promising	JJ
cord-285091-2i2v5ecg	176	29	vaccines	vaccine	NNS
cord-285091-2i2v5ecg	176	30	have	have	VBP
cord-285091-2i2v5ecg	176	31	been	be	VBN
cord-285091-2i2v5ecg	176	32	tested	test	VBN
cord-285091-2i2v5ecg	176	33	on	on	IN
cord-285091-2i2v5ecg	176	34	nonhuman	nonhuman	NN
cord-285091-2i2v5ecg	176	35	primates	primate	NNS
cord-285091-2i2v5ecg	176	36	[	[	-LRB-
cord-285091-2i2v5ecg	176	37	128	128	CD
cord-285091-2i2v5ecg	176	38	,	,	,
cord-285091-2i2v5ecg	176	39	129	129	CD
cord-285091-2i2v5ecg	176	40	]	]	-RRB-
cord-285091-2i2v5ecg	176	41	.	.	.
cord-285091-2i2v5ecg	177	1	Considering	consider	VBG
cord-285091-2i2v5ecg	177	2	the	the	DT
cord-285091-2i2v5ecg	177	3	aggressive	aggressive	JJ
cord-285091-2i2v5ecg	177	4	nature	nature	NN
cord-285091-2i2v5ecg	177	5	of	of	IN
cord-285091-2i2v5ecg	177	6	Ebola	Ebola	NNP
cord-285091-2i2v5ecg	177	7	infections	infection	NNS
cord-285091-2i2v5ecg	177	8	,	,	,
cord-285091-2i2v5ecg	177	9	in	in	IN
cord-285091-2i2v5ecg	177	10	particular	particular	JJ
cord-285091-2i2v5ecg	177	11	the	the	DT
cord-285091-2i2v5ecg	177	12	rapid	rapid	JJ
cord-285091-2i2v5ecg	177	13	and	and	CC
cord-285091-2i2v5ecg	177	14	overwhelming	overwhelming	JJ
cord-285091-2i2v5ecg	177	15	viral	viral	JJ
cord-285091-2i2v5ecg	177	16	burdens	burden	NNS
cord-285091-2i2v5ecg	177	17	,	,	,
cord-285091-2i2v5ecg	177	18	early	early	JJ
cord-285091-2i2v5ecg	177	19	treatment	treatment	NN
cord-285091-2i2v5ecg	177	20	with	with	IN
cord-285091-2i2v5ecg	177	21	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	177	22	inhibitors	inhibitor	NNS
cord-285091-2i2v5ecg	177	23	alone	alone	RB
cord-285091-2i2v5ecg	177	24	or	or	CC
cord-285091-2i2v5ecg	177	25	in	in	IN
cord-285091-2i2v5ecg	177	26	combination	combination	NN
cord-285091-2i2v5ecg	177	27	with	with	IN
cord-285091-2i2v5ecg	177	28	neutralizing	neutralize	VBG
cord-285091-2i2v5ecg	177	29	antibodies	antibody	NNS
cord-285091-2i2v5ecg	177	30	could	could	MD
cord-285091-2i2v5ecg	177	31	help	help	VB
cord-285091-2i2v5ecg	177	32	to	to	TO
cord-285091-2i2v5ecg	177	33	bring	bring	VB
cord-285091-2i2v5ecg	177	34	down	down	RP
cord-285091-2i2v5ecg	177	35	the	the	DT
cord-285091-2i2v5ecg	177	36	number	number	NN
cord-285091-2i2v5ecg	177	37	of	of	IN
cord-285091-2i2v5ecg	177	38	death	death	NN
cord-285091-2i2v5ecg	177	39	cases	case	NNS
cord-285091-2i2v5ecg	177	40	after	after	IN
cord-285091-2i2v5ecg	177	41	infection	infection	NN
cord-285091-2i2v5ecg	177	42	.	.	.
cord-285091-2i2v5ecg	178	1	Not	not	RB
cord-285091-2i2v5ecg	178	2	only	only	RB
cord-285091-2i2v5ecg	178	3	Filoviruses	Filoviruses	NNPS
cord-285091-2i2v5ecg	178	4	,	,	,
cord-285091-2i2v5ecg	178	5	but	but	CC
cord-285091-2i2v5ecg	178	6	also	also	RB
cord-285091-2i2v5ecg	178	7	some	some	DT
cord-285091-2i2v5ecg	178	8	of	of	IN
cord-285091-2i2v5ecg	178	9	Coronaviruses	Coronaviruses	NNP
cord-285091-2i2v5ecg	178	10	,	,	,
cord-285091-2i2v5ecg	178	11	positive	positive	JJ
cord-285091-2i2v5ecg	178	12	sense	sense	NN
cord-285091-2i2v5ecg	179	1	RNA	RNA	NNP
cord-285091-2i2v5ecg	179	2	viruses	virus	NNS
cord-285091-2i2v5ecg	179	3	,	,	,
cord-285091-2i2v5ecg	179	4	were	be	VBD
cord-285091-2i2v5ecg	179	5	reported	report	VBN
cord-285091-2i2v5ecg	179	6	to	to	TO
cord-285091-2i2v5ecg	179	7	entry	entry	VB
cord-285091-2i2v5ecg	179	8	the	the	DT
cord-285091-2i2v5ecg	179	9	host	host	NN
cord-285091-2i2v5ecg	179	10	cell	cell	NN
cord-285091-2i2v5ecg	179	11	by	by	IN
cord-285091-2i2v5ecg	179	12	proteases	protease	NNS
cord-285091-2i2v5ecg	179	13	dependent	dependent	JJ
cord-285091-2i2v5ecg	179	14	manner	manner	NN
cord-285091-2i2v5ecg	179	15	[	[	-LRB-
cord-285091-2i2v5ecg	179	16	130	130	CD
cord-285091-2i2v5ecg	179	17	]	]	-RRB-
cord-285091-2i2v5ecg	179	18	.	.	.
cord-285091-2i2v5ecg	180	1	Human	human	JJ
cord-285091-2i2v5ecg	180	2	coronavirus	coronavirus	NN
cord-285091-2i2v5ecg	180	3	299E	299e	CD
cord-285091-2i2v5ecg	180	4	,	,	,
cord-285091-2i2v5ecg	180	5	a	a	DT
cord-285091-2i2v5ecg	180	6	causative	causative	JJ
cord-285091-2i2v5ecg	180	7	agent	agent	NN
cord-285091-2i2v5ecg	180	8	of	of	IN
cord-285091-2i2v5ecg	180	9	the	the	DT
cord-285091-2i2v5ecg	180	10	human	human	JJ
cord-285091-2i2v5ecg	180	11	common	common	JJ
cord-285091-2i2v5ecg	180	12	cold	cold	NN
cord-285091-2i2v5ecg	180	13	,	,	,
cord-285091-2i2v5ecg	180	14	en	en	NN
cord-285091-2i2v5ecg	180	15	-	-	HYPH
cord-285091-2i2v5ecg	180	16	ters	ter	NNS
cord-285091-2i2v5ecg	180	17	cells	cell	NNS
cord-285091-2i2v5ecg	180	18	via	via	IN
cord-285091-2i2v5ecg	180	19	endosomes	endosome	NNS
cord-285091-2i2v5ecg	180	20	in	in	IN
cord-285091-2i2v5ecg	180	21	which	which	WDT
cord-285091-2i2v5ecg	180	22	cathepsins	cathepsin	NNS
cord-285091-2i2v5ecg	180	23	are	be	VBP
cord-285091-2i2v5ecg	180	24	involved	involve	VBN
cord-285091-2i2v5ecg	180	25	in	in	IN
cord-285091-2i2v5ecg	180	26	the	the	DT
cord-285091-2i2v5ecg	180	27	fusogenic	fusogenic	JJ
cord-285091-2i2v5ecg	180	28	activation	activation	NN
cord-285091-2i2v5ecg	180	29	of	of	IN
cord-285091-2i2v5ecg	180	30	229E	229E	NNP
cord-285091-2i2v5ecg	180	31	S	S	NNP
cord-285091-2i2v5ecg	180	32	protein	protein	NN
cord-285091-2i2v5ecg	180	33	[	[	-LRB-
cord-285091-2i2v5ecg	180	34	130	130	CD
cord-285091-2i2v5ecg	180	35	]	]	-RRB-
cord-285091-2i2v5ecg	180	36	.	.	.
cord-285091-2i2v5ecg	181	1	In	in	IN
cord-285091-2i2v5ecg	181	2	addition	addition	NN
cord-285091-2i2v5ecg	181	3	,	,	,
cord-285091-2i2v5ecg	181	4	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	181	5	L	L	NNP
cord-285091-2i2v5ecg	181	6	was	be	VBD
cord-285091-2i2v5ecg	181	7	reported	report	VBN
cord-285091-2i2v5ecg	181	8	to	to	TO
cord-285091-2i2v5ecg	181	9	cleave	cleave	VB
cord-285091-2i2v5ecg	181	10	spike	spike	NN
cord-285091-2i2v5ecg	181	11	(	(	-LRB-
cord-285091-2i2v5ecg	181	12	S)-protein	s)-protein	NN
cord-285091-2i2v5ecg	181	13	of	of	IN
cord-285091-2i2v5ecg	181	14	the	the	DT
cord-285091-2i2v5ecg	181	15	Severe	severe	JJ
cord-285091-2i2v5ecg	181	16	acute	acute	JJ
cord-285091-2i2v5ecg	181	17	respiratory	respiratory	JJ
cord-285091-2i2v5ecg	181	18	syndrome	syndrome	NN
cord-285091-2i2v5ecg	181	19	(	(	-LRB-
cord-285091-2i2v5ecg	181	20	SARS	SARS	NNP
cord-285091-2i2v5ecg	181	21	)	)	-RRB-
cord-285091-2i2v5ecg	181	22	coronavirus	coronavirus	NN
cord-285091-2i2v5ecg	181	23	[	[	-LRB-
cord-285091-2i2v5ecg	181	24	131	131	CD
cord-285091-2i2v5ecg	181	25	]	]	-RRB-
cord-285091-2i2v5ecg	181	26	.	.	.
cord-285091-2i2v5ecg	182	1	The	the	DT
cord-285091-2i2v5ecg	182	2	cleavage	cleavage	NN
cord-285091-2i2v5ecg	182	3	and	and	CC
cord-285091-2i2v5ecg	182	4	the	the	DT
cord-285091-2i2v5ecg	182	5	activation	activation	NN
cord-285091-2i2v5ecg	182	6	of	of	IN
cord-285091-2i2v5ecg	182	7	the	the	DT
cord-285091-2i2v5ecg	182	8	viral	viral	JJ
cord-285091-2i2v5ecg	182	9	S	S	NNP
cord-285091-2i2v5ecg	182	10	protein	protein	NN
cord-285091-2i2v5ecg	182	11	by	by	IN
cord-285091-2i2v5ecg	182	12	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	182	13	L	L	NNP
cord-285091-2i2v5ecg	182	14	induced	induce	VBD
cord-285091-2i2v5ecg	182	15	a	a	DT
cord-285091-2i2v5ecg	182	16	conformational	conformational	JJ
cord-285091-2i2v5ecg	182	17	change	change	NN
cord-285091-2i2v5ecg	182	18	in	in	IN
cord-285091-2i2v5ecg	182	19	the	the	DT
cord-285091-2i2v5ecg	182	20	Sprotein	Sprotein	NNP
cord-285091-2i2v5ecg	182	21	required	require	VBD
cord-285091-2i2v5ecg	182	22	for	for	IN
cord-285091-2i2v5ecg	182	23	the	the	DT
cord-285091-2i2v5ecg	182	24	binding	binding	NN
cord-285091-2i2v5ecg	182	25	to	to	IN
cord-285091-2i2v5ecg	182	26	the	the	DT
cord-285091-2i2v5ecg	182	27	cellular	cellular	JJ
cord-285091-2i2v5ecg	182	28	receptor	receptor	NN
cord-285091-2i2v5ecg	182	29	,	,	,
cord-285091-2i2v5ecg	182	30	angiotensin	angiotensin	NN
cord-285091-2i2v5ecg	182	31	-	-	HYPH
cord-285091-2i2v5ecg	182	32	converting	convert	VBG
cord-285091-2i2v5ecg	182	33	enzyme	enzyme	NN
cord-285091-2i2v5ecg	182	34	2	2	CD
cord-285091-2i2v5ecg	182	35	(	(	-LRB-
cord-285091-2i2v5ecg	182	36	ACE2	ACE2	NNP
cord-285091-2i2v5ecg	182	37	)	)	-RRB-
cord-285091-2i2v5ecg	182	38	[	[	-LRB-
cord-285091-2i2v5ecg	182	39	131	131	CD
cord-285091-2i2v5ecg	182	40	]	]	-RRB-
cord-285091-2i2v5ecg	182	41	.	.	.
cord-285091-2i2v5ecg	183	1	The	the	DT
cord-285091-2i2v5ecg	183	2	activation	activation	NN
cord-285091-2i2v5ecg	183	3	of	of	IN
cord-285091-2i2v5ecg	183	4	S	S	NNP
cord-285091-2i2v5ecg	183	5	protein	protein	NN
cord-285091-2i2v5ecg	183	6	involves	involve	VBZ
cord-285091-2i2v5ecg	183	7	at	at	RB
cord-285091-2i2v5ecg	183	8	least	least	RBS
cord-285091-2i2v5ecg	183	9	two	two	CD
cord-285091-2i2v5ecg	183	10	consecutive	consecutive	JJ
cord-285091-2i2v5ecg	183	11	cleavages	cleavage	NNS
cord-285091-2i2v5ecg	183	12	by	by	IN
cord-285091-2i2v5ecg	183	13	host	host	NN
cord-285091-2i2v5ecg	183	14	cell	cell	NN
cord-285091-2i2v5ecg	183	15	proteases	protease	NNS
cord-285091-2i2v5ecg	183	16	and	and	CC
cord-285091-2i2v5ecg	183	17	is	be	VBZ
cord-285091-2i2v5ecg	183	18	essential	essential	JJ
cord-285091-2i2v5ecg	183	19	for	for	IN
cord-285091-2i2v5ecg	183	20	viral	viral	JJ
cord-285091-2i2v5ecg	183	21	infectivity	infectivity	NN
cord-285091-2i2v5ecg	183	22	[	[	-LRB-
cord-285091-2i2v5ecg	183	23	132	132	CD
cord-285091-2i2v5ecg	183	24	]	]	-RRB-
cord-285091-2i2v5ecg	183	25	.	.	.
cord-285091-2i2v5ecg	184	1	Although	although	IN
cord-285091-2i2v5ecg	184	2	ACE2	ACE2	NNP
cord-285091-2i2v5ecg	184	3	is	be	VBZ
cord-285091-2i2v5ecg	184	4	a	a	DT
cord-285091-2i2v5ecg	184	5	cellular	cellular	JJ
cord-285091-2i2v5ecg	184	6	receptor	receptor	NN
cord-285091-2i2v5ecg	184	7	for	for	IN
cord-285091-2i2v5ecg	184	8	two	two	CD
cord-285091-2i2v5ecg	184	9	divergent	divergent	JJ
cord-285091-2i2v5ecg	184	10	coronaviruses	coronaviruse	NNS
cord-285091-2i2v5ecg	184	11	,	,	,
cord-285091-2i2v5ecg	184	12	SARS	SARS	NNP
cord-285091-2i2v5ecg	184	13	coronavirus	coronavirus	NN
cord-285091-2i2v5ecg	184	14	and	and	CC
cord-285091-2i2v5ecg	184	15	human	human	JJ
cord-285091-2i2v5ecg	184	16	coronavirus	coronavirus	NN
cord-285091-2i2v5ecg	185	1	NL63	NL63	NNP
cord-285091-2i2v5ecg	185	2	,	,	,
cord-285091-2i2v5ecg	185	3	it	-PRON-	PRP
cord-285091-2i2v5ecg	185	4	was	be	VBD
cord-285091-2i2v5ecg	185	5	reported	report	VBN
cord-285091-2i2v5ecg	185	6	that	that	IN
cord-285091-2i2v5ecg	185	7	the	the	DT
cord-285091-2i2v5ecg	185	8	inhibitors	inhibitor	NNS
cord-285091-2i2v5ecg	185	9	of	of	IN
cord-285091-2i2v5ecg	185	10	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	185	11	L	L	NNP
cord-285091-2i2v5ecg	185	12	blocked	block	VBD
cord-285091-2i2v5ecg	185	13	the	the	DT
cord-285091-2i2v5ecg	185	14	infection	infection	NN
cord-285091-2i2v5ecg	185	15	only	only	RB
cord-285091-2i2v5ecg	185	16	by	by	IN
cord-285091-2i2v5ecg	185	17	SARS	SARS	NNP
cord-285091-2i2v5ecg	185	18	,	,	,
cord-285091-2i2v5ecg	185	19	but	but	CC
cord-285091-2i2v5ecg	185	20	not	not	RB
cord-285091-2i2v5ecg	185	21	by	by	IN
cord-285091-2i2v5ecg	185	22	NL63	NL63	NNP
cord-285091-2i2v5ecg	185	23	virus	virus	NN
cord-285091-2i2v5ecg	185	24	[	[	-LRB-
cord-285091-2i2v5ecg	185	25	132	132	CD
cord-285091-2i2v5ecg	185	26	]	]	-RRB-
cord-285091-2i2v5ecg	185	27	.	.	.
cord-285091-2i2v5ecg	186	1	In	in	IN
cord-285091-2i2v5ecg	186	2	addition	addition	NN
cord-285091-2i2v5ecg	186	3	,	,	,
cord-285091-2i2v5ecg	186	4	expression	expression	NN
cord-285091-2i2v5ecg	186	5	of	of	IN
cord-285091-2i2v5ecg	186	6	exogenous	exogenous	JJ
cord-285091-2i2v5ecg	186	7	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	186	8	L	l	NN
cord-285091-2i2v5ecg	186	9	significantly	significantly	RB
cord-285091-2i2v5ecg	186	10	enhanced	enhance	VBN
cord-285091-2i2v5ecg	186	11	infection	infection	NN
cord-285091-2i2v5ecg	186	12	mediated	mediate	VBN
cord-285091-2i2v5ecg	186	13	by	by	IN
cord-285091-2i2v5ecg	186	14	the	the	DT
cord-285091-2i2v5ecg	186	15	SARS	SARS	NNP
cord-285091-2i2v5ecg	186	16	S	S	NNP
cord-285091-2i2v5ecg	186	17	protein	protein	NN
cord-285091-2i2v5ecg	186	18	,	,	,
cord-285091-2i2v5ecg	186	19	but	but	CC
cord-285091-2i2v5ecg	186	20	not	not	RB
cord-285091-2i2v5ecg	186	21	by	by	IN
cord-285091-2i2v5ecg	186	22	the	the	DT
cord-285091-2i2v5ecg	186	23	NL63	NL63	NNP
cord-285091-2i2v5ecg	186	24	S	S	NNP
cord-285091-2i2v5ecg	186	25	protein	protein	NN
cord-285091-2i2v5ecg	186	26	or	or	CC
cord-285091-2i2v5ecg	186	27	the	the	DT
cord-285091-2i2v5ecg	186	28	vesicular	vesicular	JJ
cord-285091-2i2v5ecg	186	29	stomatitis	stomatitis	NN
cord-285091-2i2v5ecg	186	30	virus	virus	NN
cord-285091-2i2v5ecg	186	31	G	g	NN
cord-285091-2i2v5ecg	186	32	protein	protein	NN
cord-285091-2i2v5ecg	186	33	[	[	-LRB-
cord-285091-2i2v5ecg	186	34	133	133	CD
cord-285091-2i2v5ecg	186	35	]	]	-RRB-
cord-285091-2i2v5ecg	186	36	.	.	.
cord-285091-2i2v5ecg	187	1	SARS	SARS	NNP
cord-285091-2i2v5ecg	187	2	infections	infection	NNS
cord-285091-2i2v5ecg	187	3	emerged	emerge	VBD
cord-285091-2i2v5ecg	187	4	in	in	IN
cord-285091-2i2v5ecg	187	5	2003	2003	CD
cord-285091-2i2v5ecg	187	6	affecting	affect	VBG
cord-285091-2i2v5ecg	187	7	>	>	XX
cord-285091-2i2v5ecg	187	8	8000	8000	CD
cord-285091-2i2v5ecg	187	9	persons	person	NNS
cord-285091-2i2v5ecg	187	10	and	and	CC
cord-285091-2i2v5ecg	187	11	resulting	result	VBG
cord-285091-2i2v5ecg	187	12	in	in	IN
cord-285091-2i2v5ecg	187	13	death	death	NN
cord-285091-2i2v5ecg	187	14	in	in	IN
cord-285091-2i2v5ecg	187	15	10	10	CD
cord-285091-2i2v5ecg	187	16	%	%	NN
cord-285091-2i2v5ecg	187	17	of	of	IN
cord-285091-2i2v5ecg	187	18	cases	case	NNS
cord-285091-2i2v5ecg	187	19	[	[	-LRB-
cord-285091-2i2v5ecg	187	20	134	134	CD
cord-285091-2i2v5ecg	187	21	]	]	-RRB-
cord-285091-2i2v5ecg	187	22	.	.	.
cord-285091-2i2v5ecg	188	1	Coronaviruses	Coronaviruses	NNP
cord-285091-2i2v5ecg	188	2	still	still	RB
cord-285091-2i2v5ecg	188	3	represent	represent	VBP
cord-285091-2i2v5ecg	188	4	a	a	DT
cord-285091-2i2v5ecg	188	5	leading	lead	VBG
cord-285091-2i2v5ecg	188	6	source	source	NN
cord-285091-2i2v5ecg	188	7	of	of	IN
cord-285091-2i2v5ecg	188	8	novel	novel	NN
cord-285091-2i2v5ecg	188	9	viruses	virus	NNS
cord-285091-2i2v5ecg	188	10	for	for	IN
cord-285091-2i2v5ecg	188	11	emergence	emergence	NN
cord-285091-2i2v5ecg	188	12	into	into	IN
cord-285091-2i2v5ecg	188	13	the	the	DT
cord-285091-2i2v5ecg	188	14	human	human	JJ
cord-285091-2i2v5ecg	188	15	population	population	NN
cord-285091-2i2v5ecg	188	16	[	[	-LRB-
cord-285091-2i2v5ecg	188	17	132	132	CD
cord-285091-2i2v5ecg	188	18	]	]	-RRB-
cord-285091-2i2v5ecg	188	19	.	.	.
cord-285091-2i2v5ecg	189	1	Recently	recently	RB
cord-285091-2i2v5ecg	189	2	,	,	,
cord-285091-2i2v5ecg	189	3	several	several	JJ
cord-285091-2i2v5ecg	189	4	neutralizing	neutralize	VBG
cord-285091-2i2v5ecg	189	5	antibodies	antibody	NNS
cord-285091-2i2v5ecg	189	6	have	have	VBP
cord-285091-2i2v5ecg	189	7	been	be	VBN
cord-285091-2i2v5ecg	189	8	developed	develop	VBN
cord-285091-2i2v5ecg	189	9	and	and	CC
cord-285091-2i2v5ecg	189	10	some	some	DT
cord-285091-2i2v5ecg	189	11	of	of	IN
cord-285091-2i2v5ecg	189	12	them	-PRON-	PRP
cord-285091-2i2v5ecg	189	13	showed	show	VBD
cord-285091-2i2v5ecg	189	14	promising	promising	JJ
cord-285091-2i2v5ecg	189	15	results	result	NNS
cord-285091-2i2v5ecg	189	16	in	in	IN
cord-285091-2i2v5ecg	189	17	the	the	DT
cord-285091-2i2v5ecg	189	18	therapy	therapy	NN
cord-285091-2i2v5ecg	189	19	of	of	IN
cord-285091-2i2v5ecg	189	20	non	non	JJ
cord-285091-2i2v5ecg	189	21	-	-	JJ
cord-285091-2i2v5ecg	189	22	human	human	JJ
cord-285091-2i2v5ecg	189	23	primates	primate	NNS
cord-285091-2i2v5ecg	189	24	[	[	-LRB-
cord-285091-2i2v5ecg	189	25	135	135	CD
cord-285091-2i2v5ecg	189	26	]	]	-RRB-
cord-285091-2i2v5ecg	189	27	.	.	.
cord-285091-2i2v5ecg	190	1	However	however	RB
cord-285091-2i2v5ecg	190	2	,	,	,
cord-285091-2i2v5ecg	190	3	the	the	DT
cord-285091-2i2v5ecg	190	4	combinational	combinational	JJ
cord-285091-2i2v5ecg	190	5	therapy	therapy	NN
cord-285091-2i2v5ecg	190	6	with	with	IN
cord-285091-2i2v5ecg	190	7	antibodies	antibody	NNS
cord-285091-2i2v5ecg	190	8	and	and	CC
cord-285091-2i2v5ecg	190	9	inhibitors	inhibitor	NNS
cord-285091-2i2v5ecg	190	10	could	could	MD
cord-285091-2i2v5ecg	190	11	have	have	VB
cord-285091-2i2v5ecg	190	12	several	several	JJ
cord-285091-2i2v5ecg	190	13	advantages	advantage	NNS
cord-285091-2i2v5ecg	190	14	.	.	.
cord-285091-2i2v5ecg	191	1	Paramyxoviruses	paramyxovirus	NNS
cord-285091-2i2v5ecg	191	2	are	be	VBP
cord-285091-2i2v5ecg	191	3	enveloped	envelop	VBN
cord-285091-2i2v5ecg	191	4	,	,	,
cord-285091-2i2v5ecg	191	5	single	single	RB
cord-285091-2i2v5ecg	191	6	-	-	HYPH
cord-285091-2i2v5ecg	191	7	stranded	stranded	JJ
cord-285091-2i2v5ecg	191	8	,	,	,
cord-285091-2i2v5ecg	191	9	negative	negative	JJ
cord-285091-2i2v5ecg	191	10	-	-	HYPH
cord-285091-2i2v5ecg	191	11	sense	sense	NN
cord-285091-2i2v5ecg	191	12	RNA	RNA	NNP
cord-285091-2i2v5ecg	191	13	viruses	virus	NNS
cord-285091-2i2v5ecg	191	14	which	which	WDT
cord-285091-2i2v5ecg	191	15	include	include	VBP
cord-285091-2i2v5ecg	191	16	a	a	DT
cord-285091-2i2v5ecg	191	17	number	number	NN
cord-285091-2i2v5ecg	191	18	of	of	IN
cord-285091-2i2v5ecg	191	19	major	major	JJ
cord-285091-2i2v5ecg	191	20	human	human	JJ
cord-285091-2i2v5ecg	191	21	pathogens	pathogen	NNS
cord-285091-2i2v5ecg	191	22	,	,	,
cord-285091-2i2v5ecg	191	23	such	such	JJ
cord-285091-2i2v5ecg	191	24	as	as	IN
cord-285091-2i2v5ecg	191	25	measles	measle	NNS
cord-285091-2i2v5ecg	191	26	virus	virus	NN
cord-285091-2i2v5ecg	191	27	,	,	,
cord-285091-2i2v5ecg	191	28	mumps	mumps	NN
cord-285091-2i2v5ecg	191	29	virus	virus	NN
cord-285091-2i2v5ecg	191	30	,	,	,
cord-285091-2i2v5ecg	191	31	human	human	JJ
cord-285091-2i2v5ecg	191	32	respiratory	respiratory	JJ
cord-285091-2i2v5ecg	191	33	syncytial	syncytial	JJ
cord-285091-2i2v5ecg	191	34	virus	virus	NN
cord-285091-2i2v5ecg	191	35	,	,	,
cord-285091-2i2v5ecg	191	36	and	and	CC
cord-285091-2i2v5ecg	191	37	Hendra	Hendra	NNP
cord-285091-2i2v5ecg	191	38	and	and	CC
cord-285091-2i2v5ecg	191	39	Nipah	Nipah	NNP
cord-285091-2i2v5ecg	191	40	virus	virus	NN
cord-285091-2i2v5ecg	191	41	[	[	-LRB-
cord-285091-2i2v5ecg	191	42	136	136	CD
cord-285091-2i2v5ecg	191	43	]	]	-RRB-
cord-285091-2i2v5ecg	191	44	.	.	.
cord-285091-2i2v5ecg	192	1	Proteolytic	proteolytic	JJ
cord-285091-2i2v5ecg	192	2	activation	activation	NN
cord-285091-2i2v5ecg	192	3	of	of	IN
cord-285091-2i2v5ecg	192	4	the	the	DT
cord-285091-2i2v5ecg	192	5	fusion	fusion	NN
cord-285091-2i2v5ecg	192	6	protein	protein	NN
cord-285091-2i2v5ecg	192	7	of	of	IN
cord-285091-2i2v5ecg	192	8	the	the	DT
cord-285091-2i2v5ecg	192	9	Nipah	Nipah	NNP
cord-285091-2i2v5ecg	192	10	virus	virus	NN
cord-285091-2i2v5ecg	192	11	is	be	VBZ
cord-285091-2i2v5ecg	192	12	a	a	DT
cord-285091-2i2v5ecg	192	13	prerequisite	prerequisite	NN
cord-285091-2i2v5ecg	192	14	for	for	IN
cord-285091-2i2v5ecg	192	15	the	the	DT
cord-285091-2i2v5ecg	192	16	production	production	NN
cord-285091-2i2v5ecg	192	17	of	of	IN
cord-285091-2i2v5ecg	192	18	infectious	infectious	JJ
cord-285091-2i2v5ecg	192	19	particles	particle	NNS
cord-285091-2i2v5ecg	192	20	and	and	CC
cord-285091-2i2v5ecg	192	21	for	for	IN
cord-285091-2i2v5ecg	192	22	virus	virus	NN
cord-285091-2i2v5ecg	192	23	spread	spread	VBN
cord-285091-2i2v5ecg	192	24	via	via	IN
cord-285091-2i2v5ecg	192	25	cell	cell	NN
cord-285091-2i2v5ecg	192	26	-	-	HYPH
cord-285091-2i2v5ecg	192	27	to	to	IN
cord-285091-2i2v5ecg	192	28	-	-	HYPH
cord-285091-2i2v5ecg	192	29	cell	cell	NN
cord-285091-2i2v5ecg	192	30	fusion	fusion	NN
cord-285091-2i2v5ecg	192	31	[	[	-LRB-
cord-285091-2i2v5ecg	192	32	136	136	CD
cord-285091-2i2v5ecg	192	33	]	]	-RRB-
cord-285091-2i2v5ecg	192	34	.	.	.
cord-285091-2i2v5ecg	193	1	Recently	recently	RB
cord-285091-2i2v5ecg	193	2	cathepsins	cathepsin	VBZ
cord-285091-2i2v5ecg	193	3	B	B	NNP
cord-285091-2i2v5ecg	193	4	and	and	CC
cord-285091-2i2v5ecg	193	5	L	L	NNP
cord-285091-2i2v5ecg	193	6	were	be	VBD
cord-285091-2i2v5ecg	193	7	reported	report	VBN
cord-285091-2i2v5ecg	193	8	to	to	TO
cord-285091-2i2v5ecg	193	9	be	be	VB
cord-285091-2i2v5ecg	193	10	required	require	VBN
cord-285091-2i2v5ecg	193	11	for	for	IN
cord-285091-2i2v5ecg	193	12	the	the	DT
cord-285091-2i2v5ecg	193	13	cleavage	cleavage	NN
cord-285091-2i2v5ecg	193	14	and	and	CC
cord-285091-2i2v5ecg	193	15	productive	productive	JJ
cord-285091-2i2v5ecg	193	16	replication	replication	NN
cord-285091-2i2v5ecg	193	17	of	of	IN
cord-285091-2i2v5ecg	193	18	pathogenic	pathogenic	JJ
cord-285091-2i2v5ecg	193	19	Nipah	Nipah	NNP
cord-285091-2i2v5ecg	193	20	virus	virus	NN
cord-285091-2i2v5ecg	193	21	,	,	,
cord-285091-2i2v5ecg	193	22	but	but	CC
cord-285091-2i2v5ecg	193	23	not	not	RB
cord-285091-2i2v5ecg	193	24	Hendra	Hendra	NNP
cord-285091-2i2v5ecg	193	25	virus	virus	NN
cord-285091-2i2v5ecg	193	26	[	[	-LRB-
cord-285091-2i2v5ecg	193	27	137	137	CD
cord-285091-2i2v5ecg	193	28	]	]	-RRB-
cord-285091-2i2v5ecg	193	29	.	.	.
cord-285091-2i2v5ecg	194	1	Reoviruses	Reoviruses	NNP
cord-285091-2i2v5ecg	194	2	form	form	VBP
cord-285091-2i2v5ecg	194	3	non	non	AFX
cord-285091-2i2v5ecg	194	4	-	-	JJ
cord-285091-2i2v5ecg	194	5	enveloped	enveloped	JJ
cord-285091-2i2v5ecg	194	6	,	,	,
cord-285091-2i2v5ecg	194	7	double	double	RB
cord-285091-2i2v5ecg	194	8	-	-	HYPH
cord-285091-2i2v5ecg	194	9	stranded	strand	VBN
cord-285091-2i2v5ecg	194	10	RNA	RNA	NNP
cord-285091-2i2v5ecg	194	11	viruses	virus	NNS
cord-285091-2i2v5ecg	194	12	.	.	.
cord-285091-2i2v5ecg	195	1	The	the	DT
cord-285091-2i2v5ecg	195	2	virus	virus	NN
cord-285091-2i2v5ecg	195	3	entry	entry	NN
cord-285091-2i2v5ecg	195	4	into	into	IN
cord-285091-2i2v5ecg	195	5	cells	cell	NNS
cord-285091-2i2v5ecg	195	6	is	be	VBZ
cord-285091-2i2v5ecg	195	7	initiated	initiate	VBN
cord-285091-2i2v5ecg	195	8	by	by	IN
cord-285091-2i2v5ecg	195	9	the	the	DT
cord-285091-2i2v5ecg	195	10	attachment	attachment	NN
cord-285091-2i2v5ecg	195	11	of	of	IN
cord-285091-2i2v5ecg	195	12	virions	virion	NNS
cord-285091-2i2v5ecg	195	13	to	to	IN
cord-285091-2i2v5ecg	195	14	cell	cell	NN
cord-285091-2i2v5ecg	195	15	surface	surface	NN
cord-285091-2i2v5ecg	195	16	receptors	receptor	NNS
cord-285091-2i2v5ecg	195	17	[	[	-LRB-
cord-285091-2i2v5ecg	195	18	138	138	CD
cord-285091-2i2v5ecg	195	19	]	]	-RRB-
cord-285091-2i2v5ecg	195	20	and	and	CC
cord-285091-2i2v5ecg	195	21	by	by	IN
cord-285091-2i2v5ecg	195	22	receptor	receptor	NN
cord-285091-2i2v5ecg	195	23	-	-	HYPH
cord-285091-2i2v5ecg	195	24	mediated	mediate	VBN
cord-285091-2i2v5ecg	195	25	endocytosis	endocytosis	NN
cord-285091-2i2v5ecg	195	26	[	[	-LRB-
cord-285091-2i2v5ecg	195	27	139	139	CD
cord-285091-2i2v5ecg	195	28	]	]	-RRB-
cord-285091-2i2v5ecg	195	29	.	.	.
cord-285091-2i2v5ecg	196	1	In	in	IN
cord-285091-2i2v5ecg	196	2	the	the	DT
cord-285091-2i2v5ecg	196	3	host	host	NN
cord-285091-2i2v5ecg	196	4	cell	cell	NN
cord-285091-2i2v5ecg	196	5	endolysosomes	endolysosome	NNS
cord-285091-2i2v5ecg	196	6	,	,	,
cord-285091-2i2v5ecg	196	7	virions	virion	NNS
cord-285091-2i2v5ecg	196	8	undergo	undergo	VBP
cord-285091-2i2v5ecg	196	9	stepwise	stepwise	JJ
cord-285091-2i2v5ecg	196	10	disassembly	disassembly	NN
cord-285091-2i2v5ecg	196	11	,	,	,
cord-285091-2i2v5ecg	196	12	forming	form	VBG
cord-285091-2i2v5ecg	196	13	discrete	discrete	JJ
cord-285091-2i2v5ecg	196	14	intermediates	intermediate	NNS
cord-285091-2i2v5ecg	196	15	,	,	,
cord-285091-2i2v5ecg	196	16	the	the	DT
cord-285091-2i2v5ecg	196	17	first	first	JJ
cord-285091-2i2v5ecg	196	18	of	of	IN
cord-285091-2i2v5ecg	196	19	which	which	WDT
cord-285091-2i2v5ecg	196	20	is	be	VBZ
cord-285091-2i2v5ecg	196	21	the	the	DT
cord-285091-2i2v5ecg	196	22	infectious	infectious	JJ
cord-285091-2i2v5ecg	196	23	subvirion	subvirion	NN
cord-285091-2i2v5ecg	196	24	particle	particle	NN
cord-285091-2i2v5ecg	196	25	[	[	-LRB-
cord-285091-2i2v5ecg	196	26	139	139	CD
cord-285091-2i2v5ecg	196	27	]	]	-RRB-
cord-285091-2i2v5ecg	196	28	.	.	.
cord-285091-2i2v5ecg	197	1	A	a	DT
cord-285091-2i2v5ecg	197	2	recent	recent	JJ
cord-285091-2i2v5ecg	197	3	study	study	NN
cord-285091-2i2v5ecg	197	4	examined	examine	VBD
cord-285091-2i2v5ecg	197	5	a	a	DT
cord-285091-2i2v5ecg	197	6	contribution	contribution	NN
cord-285091-2i2v5ecg	197	7	of	of	IN
cord-285091-2i2v5ecg	197	8	individual	individual	JJ
cord-285091-2i2v5ecg	197	9	cathepsins	cathepsin	NNS
cord-285091-2i2v5ecg	197	10	B	B	NNP
cord-285091-2i2v5ecg	197	11	,	,	,
cord-285091-2i2v5ecg	197	12	L	L	NNP
cord-285091-2i2v5ecg	197	13	and	and	CC
cord-285091-2i2v5ecg	197	14	S	S	NNP
cord-285091-2i2v5ecg	197	15	to	to	IN
cord-285091-2i2v5ecg	197	16	the	the	DT
cord-285091-2i2v5ecg	197	17	virus	virus	NN
cord-285091-2i2v5ecg	197	18	spread	spread	VBN
cord-285091-2i2v5ecg	197	19	in	in	IN
cord-285091-2i2v5ecg	197	20	newborn	newborn	JJ
cord-285091-2i2v5ecg	197	21	mice	mouse	NNS
cord-285091-2i2v5ecg	197	22	[	[	-LRB-
cord-285091-2i2v5ecg	197	23	140	140	CD
cord-285091-2i2v5ecg	197	24	]	]	-RRB-
cord-285091-2i2v5ecg	197	25	.	.	.
cord-285091-2i2v5ecg	198	1	In	in	IN
cord-285091-2i2v5ecg	198	2	was	be	VBD
cord-285091-2i2v5ecg	198	3	shown	show	VBN
cord-285091-2i2v5ecg	198	4	that	that	IN
cord-285091-2i2v5ecg	198	5	the	the	DT
cord-285091-2i2v5ecg	198	6	survival	survival	NN
cord-285091-2i2v5ecg	198	7	rate	rate	NN
cord-285091-2i2v5ecg	198	8	of	of	IN
cord-285091-2i2v5ecg	198	9	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	198	10	B	b	NN
cord-285091-2i2v5ecg	198	11	-	-	HYPH
cord-285091-2i2v5ecg	198	12	deficient	deficient	JJ
cord-285091-2i2v5ecg	198	13	mice	mouse	NNS
cord-285091-2i2v5ecg	198	14	was	be	VBD
cord-285091-2i2v5ecg	198	15	enhanced	enhance	VBN
cord-285091-2i2v5ecg	198	16	in	in	IN
cord-285091-2i2v5ecg	198	17	comparison	comparison	NN
cord-285091-2i2v5ecg	198	18	to	to	IN
cord-285091-2i2v5ecg	198	19	that	that	DT
cord-285091-2i2v5ecg	198	20	of	of	IN
cord-285091-2i2v5ecg	198	21	wild	wild	JJ
cord-285091-2i2v5ecg	198	22	type	type	NN
cord-285091-2i2v5ecg	198	23	mice	mouse	NNS
cord-285091-2i2v5ecg	198	24	,	,	,
cord-285091-2i2v5ecg	198	25	whereas	whereas	IN
cord-285091-2i2v5ecg	198	26	the	the	DT
cord-285091-2i2v5ecg	198	27	survival	survival	NN
cord-285091-2i2v5ecg	198	28	rates	rate	NNS
cord-285091-2i2v5ecg	198	29	of	of	IN
cord-285091-2i2v5ecg	198	30	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	198	31	L	l	NN
cord-285091-2i2v5ecg	198	32	and	and	CC
cord-285091-2i2v5ecg	198	33	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	198	34	S	s	NN
cord-285091-2i2v5ecg	198	35	deficient	deficient	JJ
cord-285091-2i2v5ecg	198	36	mice	mouse	NNS
cord-285091-2i2v5ecg	198	37	were	be	VBD
cord-285091-2i2v5ecg	198	38	weakened	weaken	VBN
cord-285091-2i2v5ecg	198	39	.	.	.
cord-285091-2i2v5ecg	199	1	Virus	virus	NN
cord-285091-2i2v5ecg	199	2	titers	titer	NNS
cord-285091-2i2v5ecg	199	3	at	at	IN
cord-285091-2i2v5ecg	199	4	sites	site	NNS
cord-285091-2i2v5ecg	199	5	of	of	IN
cord-285091-2i2v5ecg	199	6	secondary	secondary	JJ
cord-285091-2i2v5ecg	199	7	replication	replication	NN
cord-285091-2i2v5ecg	199	8	in	in	IN
cord-285091-2i2v5ecg	199	9	all	all	DT
cord-285091-2i2v5ecg	199	10	strains	strain	NNS
cord-285091-2i2v5ecg	199	11	of	of	IN
cord-285091-2i2v5ecg	199	12	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	199	13	-	-	HYPH
cord-285091-2i2v5ecg	199	14	deficient	deficient	JJ
cord-285091-2i2v5ecg	199	15	mice	mouse	NNS
cord-285091-2i2v5ecg	199	16	were	be	VBD
cord-285091-2i2v5ecg	199	17	lower	low	JJR
cord-285091-2i2v5ecg	199	18	than	than	IN
cord-285091-2i2v5ecg	199	19	those	those	DT
cord-285091-2i2v5ecg	199	20	in	in	IN
cord-285091-2i2v5ecg	199	21	wild	wild	JJ
cord-285091-2i2v5ecg	199	22	type	type	NN
cord-285091-2i2v5ecg	199	23	mice	mouse	NNS
cord-285091-2i2v5ecg	199	24	,	,	,
cord-285091-2i2v5ecg	199	25	indicating	indicate	VBG
cord-285091-2i2v5ecg	199	26	that	that	IN
cord-285091-2i2v5ecg	199	27	all	all	DT
cord-285091-2i2v5ecg	199	28	cathepsins	cathepsin	NNS
cord-285091-2i2v5ecg	199	29	could	could	MD
cord-285091-2i2v5ecg	199	30	participate	participate	VB
cord-285091-2i2v5ecg	199	31	in	in	IN
cord-285091-2i2v5ecg	199	32	the	the	DT
cord-285091-2i2v5ecg	199	33	spread	spread	NN
cord-285091-2i2v5ecg	199	34	of	of	IN
cord-285091-2i2v5ecg	199	35	the	the	DT
cord-285091-2i2v5ecg	199	36	virus	virus	NN
cord-285091-2i2v5ecg	199	37	.	.	.
cord-285091-2i2v5ecg	200	1	Clearance	clearance	NN
cord-285091-2i2v5ecg	200	2	of	of	IN
cord-285091-2i2v5ecg	200	3	the	the	DT
cord-285091-2i2v5ecg	200	4	virus	virus	NN
cord-285091-2i2v5ecg	200	5	was	be	VBD
cord-285091-2i2v5ecg	200	6	delayed	delay	VBN
cord-285091-2i2v5ecg	200	7	in	in	IN
cord-285091-2i2v5ecg	200	8	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	200	9	L	l	NN
cord-285091-2i2v5ecg	200	10	-	-	:
cord-285091-2i2v5ecg	200	11	and	and	CC
cord-285091-2i2v5ecg	200	12	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	200	13	S	s	NN
cord-285091-2i2v5ecg	200	14	-	-	HYPH
cord-285091-2i2v5ecg	200	15	deficient	deficient	JJ
cord-285091-2i2v5ecg	200	16	mice	mouse	NNS
cord-285091-2i2v5ecg	200	17	in	in	IN
cord-285091-2i2v5ecg	200	18	comparison	comparison	NN
cord-285091-2i2v5ecg	200	19	to	to	IN
cord-285091-2i2v5ecg	200	20	the	the	DT
cord-285091-2i2v5ecg	200	21	levels	level	NNS
cord-285091-2i2v5ecg	200	22	for	for	IN
cord-285091-2i2v5ecg	200	23	wild	wild	JJ
cord-285091-2i2v5ecg	200	24	type	type	NN
cord-285091-2i2v5ecg	200	25	and	and	CC
cord-285091-2i2v5ecg	200	26	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	200	27	B	b	NN
cord-285091-2i2v5ecg	200	28	-	-	HYPH
cord-285091-2i2v5ecg	200	29	deficient	deficient	JJ
cord-285091-2i2v5ecg	200	30	mice	mouse	NNS
cord-285091-2i2v5ecg	200	31	,	,	,
cord-285091-2i2v5ecg	200	32	as	as	IN
cord-285091-2i2v5ecg	200	33	a	a	DT
cord-285091-2i2v5ecg	200	34	consequence	consequence	NN
cord-285091-2i2v5ecg	200	35	of	of	IN
cord-285091-2i2v5ecg	200	36	the	the	DT
cord-285091-2i2v5ecg	200	37	important	important	JJ
cord-285091-2i2v5ecg	200	38	functions	function	NNS
cord-285091-2i2v5ecg	200	39	of	of	IN
cord-285091-2i2v5ecg	200	40	the	the	DT
cord-285091-2i2v5ecg	200	41	two	two	CD
cord-285091-2i2v5ecg	200	42	cathepsins	cathepsin	NNS
cord-285091-2i2v5ecg	200	43	in	in	IN
cord-285091-2i2v5ecg	200	44	immune	immune	JJ
cord-285091-2i2v5ecg	200	45	response	response	NN
cord-285091-2i2v5ecg	200	46	[	[	-LRB-
cord-285091-2i2v5ecg	200	47	140	140	CD
cord-285091-2i2v5ecg	200	48	]	]	-RRB-
cord-285091-2i2v5ecg	200	49	.	.	.
cord-285091-2i2v5ecg	201	1	The	the	DT
cord-285091-2i2v5ecg	201	2	study	study	NN
cord-285091-2i2v5ecg	201	3	shows	show	VBZ
cord-285091-2i2v5ecg	201	4	that	that	IN
cord-285091-2i2v5ecg	201	5	the	the	DT
cord-285091-2i2v5ecg	201	6	functions	function	NNS
cord-285091-2i2v5ecg	201	7	of	of	IN
cord-285091-2i2v5ecg	201	8	proteinases	proteinase	NNS
cord-285091-2i2v5ecg	201	9	in	in	IN
cord-285091-2i2v5ecg	201	10	the	the	DT
cord-285091-2i2v5ecg	201	11	virus	virus	NN
cord-285091-2i2v5ecg	201	12	entry	entry	NN
cord-285091-2i2v5ecg	201	13	into	into	IN
cord-285091-2i2v5ecg	201	14	the	the	DT
cord-285091-2i2v5ecg	201	15	cell	cell	NN
cord-285091-2i2v5ecg	201	16	as	as	RB
cord-285091-2i2v5ecg	201	17	well	well	RB
cord-285091-2i2v5ecg	201	18	as	as	IN
cord-285091-2i2v5ecg	201	19	in	in	IN
cord-285091-2i2v5ecg	201	20	host	host	NN
cord-285091-2i2v5ecg	201	21	immune	immune	JJ
cord-285091-2i2v5ecg	201	22	response	response	NN
cord-285091-2i2v5ecg	201	23	are	be	VBP
cord-285091-2i2v5ecg	201	24	relevant	relevant	JJ
cord-285091-2i2v5ecg	201	25	for	for	IN
cord-285091-2i2v5ecg	201	26	the	the	DT
cord-285091-2i2v5ecg	201	27	possible	possible	JJ
cord-285091-2i2v5ecg	201	28	therapy	therapy	NN
cord-285091-2i2v5ecg	201	29	with	with	IN
cord-285091-2i2v5ecg	201	30	inhibitors	inhibitor	NNS
cord-285091-2i2v5ecg	201	31	.	.	.
cord-285091-2i2v5ecg	202	1	During	during	IN
cord-285091-2i2v5ecg	202	2	the	the	DT
cord-285091-2i2v5ecg	202	3	last	last	JJ
cord-285091-2i2v5ecg	202	4	decade	decade	NN
cord-285091-2i2v5ecg	202	5	,	,	,
cord-285091-2i2v5ecg	202	6	our	-PRON-	PRP$
cord-285091-2i2v5ecg	202	7	understanding	understanding	NN
cord-285091-2i2v5ecg	202	8	of	of	IN
cord-285091-2i2v5ecg	202	9	both	both	CC
cord-285091-2i2v5ecg	202	10	adaptive	adaptive	JJ
cord-285091-2i2v5ecg	202	11	and	and	CC
cord-285091-2i2v5ecg	202	12	innate	innate	JJ
cord-285091-2i2v5ecg	202	13	immune	immune	JJ
cord-285091-2i2v5ecg	202	14	responses	response	NNS
cord-285091-2i2v5ecg	202	15	has	have	VBZ
cord-285091-2i2v5ecg	202	16	greatly	greatly	RB
cord-285091-2i2v5ecg	202	17	increased	increase	VBN
cord-285091-2i2v5ecg	202	18	.	.	.
cord-285091-2i2v5ecg	203	1	Cysteine	cysteine	NN
cord-285091-2i2v5ecg	203	2	cathepsins	cathepsin	NNS
cord-285091-2i2v5ecg	203	3	were	be	VBD
cord-285091-2i2v5ecg	203	4	shown	show	VBN
cord-285091-2i2v5ecg	203	5	to	to	TO
cord-285091-2i2v5ecg	203	6	play	play	VB
cord-285091-2i2v5ecg	203	7	some	some	DT
cord-285091-2i2v5ecg	203	8	unexpected	unexpected	JJ
cord-285091-2i2v5ecg	203	9	,	,	,
cord-285091-2i2v5ecg	203	10	yet	yet	CC
cord-285091-2i2v5ecg	203	11	not	not	RB
cord-285091-2i2v5ecg	203	12	completely	completely	RB
cord-285091-2i2v5ecg	203	13	understood	understand	VBD
cord-285091-2i2v5ecg	203	14	roles	role	NNS
cord-285091-2i2v5ecg	203	15	in	in	IN
cord-285091-2i2v5ecg	203	16	the	the	DT
cord-285091-2i2v5ecg	203	17	endosomal	endosomal	JJ
cord-285091-2i2v5ecg	203	18	TLR	TLR	NNP
cord-285091-2i2v5ecg	203	19	activation	activation	NN
cord-285091-2i2v5ecg	203	20	and	and	CC
cord-285091-2i2v5ecg	203	21	in	in	IN
cord-285091-2i2v5ecg	203	22	the	the	DT
cord-285091-2i2v5ecg	203	23	NLRP3	NLRP3	NNP
cord-285091-2i2v5ecg	203	24	inflammasome	inflammasome	NNP
cord-285091-2i2v5ecg	203	25	activation	activation	NN
cord-285091-2i2v5ecg	203	26	.	.	.
cord-285091-2i2v5ecg	204	1	The	the	DT
cord-285091-2i2v5ecg	204	2	role	role	NN
cord-285091-2i2v5ecg	204	3	of	of	IN
cord-285091-2i2v5ecg	204	4	endogenous	endogenous	JJ
cord-285091-2i2v5ecg	204	5	inhibitors	inhibitor	NNS
cord-285091-2i2v5ecg	204	6	as	as	RB
cord-285091-2i2v5ecg	204	7	well	well	RB
cord-285091-2i2v5ecg	204	8	as	as	IN
cord-285091-2i2v5ecg	204	9	pathogen	pathogen	NN
cord-285091-2i2v5ecg	204	10	proteinases	proteinase	NNS
cord-285091-2i2v5ecg	204	11	and	and	CC
cord-285091-2i2v5ecg	204	12	inhibitors	inhibitor	NNS
cord-285091-2i2v5ecg	204	13	in	in	IN
cord-285091-2i2v5ecg	204	14	this	this	DT
cord-285091-2i2v5ecg	204	15	process	process	NN
cord-285091-2i2v5ecg	204	16	is	be	VBZ
cord-285091-2i2v5ecg	204	17	still	still	RB
cord-285091-2i2v5ecg	204	18	elusive	elusive	JJ
cord-285091-2i2v5ecg	204	19	.	.	.
cord-285091-2i2v5ecg	205	1	Although	although	IN
cord-285091-2i2v5ecg	205	2	protease	protease	NN
cord-285091-2i2v5ecg	205	3	inhibitors	inhibitor	NNS
cord-285091-2i2v5ecg	205	4	have	have	VBP
cord-285091-2i2v5ecg	205	5	a	a	DT
cord-285091-2i2v5ecg	205	6	potential	potential	JJ
cord-285091-2i2v5ecg	205	7	use	use	NN
cord-285091-2i2v5ecg	205	8	as	as	IN
cord-285091-2i2v5ecg	205	9	therapeutics	therapeutic	NNS
cord-285091-2i2v5ecg	205	10	in	in	IN
cord-285091-2i2v5ecg	205	11	virus	virus	NN
cord-285091-2i2v5ecg	205	12	infections	infection	NNS
cord-285091-2i2v5ecg	205	13	,	,	,
cord-285091-2i2v5ecg	205	14	the	the	DT
cord-285091-2i2v5ecg	205	15	effects	effect	NNS
cord-285091-2i2v5ecg	205	16	on	on	IN
cord-285091-2i2v5ecg	205	17	innate	innate	JJ
cord-285091-2i2v5ecg	205	18	and	and	CC
cord-285091-2i2v5ecg	205	19	adaptive	adaptive	JJ
cord-285091-2i2v5ecg	205	20	immune	immune	JJ
cord-285091-2i2v5ecg	205	21	response	response	NN
cord-285091-2i2v5ecg	205	22	should	should	MD
cord-285091-2i2v5ecg	205	23	not	not	RB
cord-285091-2i2v5ecg	205	24	be	be	VB
cord-285091-2i2v5ecg	205	25	underestimated	underestimate	VBN
cord-285091-2i2v5ecg	205	26	.	.	.
cord-285091-2i2v5ecg	206	1	The	the	DT
cord-285091-2i2v5ecg	206	2	understanding	understanding	NN
cord-285091-2i2v5ecg	206	3	of	of	IN
cord-285091-2i2v5ecg	206	4	the	the	DT
cord-285091-2i2v5ecg	206	5	mechanisms	mechanism	NNS
cord-285091-2i2v5ecg	206	6	by	by	IN
cord-285091-2i2v5ecg	206	7	which	which	WDT
cord-285091-2i2v5ecg	206	8	proteinases	proteinases	NNP
cord-285091-2i2v5ecg	206	9	and	and	CC
cord-285091-2i2v5ecg	206	10	inhibitors	inhibitor	NNS
cord-285091-2i2v5ecg	206	11	used	use	VBN
cord-285091-2i2v5ecg	206	12	by	by	IN
cord-285091-2i2v5ecg	206	13	the	the	DT
cord-285091-2i2v5ecg	206	14	pathogens	pathogen	NNS
cord-285091-2i2v5ecg	206	15	interfere	interfere	VBP
cord-285091-2i2v5ecg	206	16	with	with	IN
cord-285091-2i2v5ecg	206	17	the	the	DT
cord-285091-2i2v5ecg	206	18	host	host	NN
cord-285091-2i2v5ecg	206	19	adaptive	adaptive	JJ
cord-285091-2i2v5ecg	206	20	and	and	CC
cord-285091-2i2v5ecg	206	21	innate	innate	JJ
cord-285091-2i2v5ecg	206	22	immune	immune	JJ
cord-285091-2i2v5ecg	206	23	response	response	NN
cord-285091-2i2v5ecg	206	24	is	be	VBZ
cord-285091-2i2v5ecg	206	25	essential	essential	JJ
cord-285091-2i2v5ecg	206	26	for	for	IN
cord-285091-2i2v5ecg	206	27	the	the	DT
cord-285091-2i2v5ecg	206	28	development	development	NN
cord-285091-2i2v5ecg	206	29	of	of	IN
cord-285091-2i2v5ecg	206	30	therapeutic	therapeutic	JJ
cord-285091-2i2v5ecg	206	31	inhibitors	inhibitor	NNS
cord-285091-2i2v5ecg	206	32	.	.	.
cord-285091-2i2v5ecg	207	1	The	the	DT
cord-285091-2i2v5ecg	207	2	author(s	author(s	NNP
cord-285091-2i2v5ecg	207	3	)	)	-RRB-
cord-285091-2i2v5ecg	207	4	confirm	confirm	VBP
cord-285091-2i2v5ecg	207	5	that	that	IN
cord-285091-2i2v5ecg	207	6	this	this	DT
cord-285091-2i2v5ecg	207	7	article	article	NN
cord-285091-2i2v5ecg	207	8	content	content	NN
cord-285091-2i2v5ecg	207	9	has	have	VBZ
cord-285091-2i2v5ecg	207	10	no	no	DT
cord-285091-2i2v5ecg	207	11	conflicts	conflict	NNS
cord-285091-2i2v5ecg	207	12	of	of	IN
cord-285091-2i2v5ecg	207	13	interest	interest	NN
cord-285091-2i2v5ecg	207	14	.	.	.
cord-285091-2i2v5ecg	208	1	Innate	innate	JJ
cord-285091-2i2v5ecg	208	2	immune	immune	JJ
cord-285091-2i2v5ecg	208	3	recognition	recognition	NN
cord-285091-2i2v5ecg	208	4	Approaching	approach	VBG
cord-285091-2i2v5ecg	208	5	the	the	DT
cord-285091-2i2v5ecg	208	6	asymptote	asymptote	NN
cord-285091-2i2v5ecg	208	7	?	?	.
cord-285091-2i2v5ecg	209	1	Evolution	evolution	NN
cord-285091-2i2v5ecg	209	2	and	and	CC
cord-285091-2i2v5ecg	209	3	revolution	revolution	NN
cord-285091-2i2v5ecg	209	4	in	in	IN
cord-285091-2i2v5ecg	209	5	immunology	immunology	NN
cord-285091-2i2v5ecg	209	6	.	.	.
cord-285091-2i2v5ecg	210	1	Cold	Cold	NNP
cord-285091-2i2v5ecg	210	2	Spring	Spring	NNP
cord-285091-2i2v5ecg	210	3	Harbor	Harbor	NNP
cord-285091-2i2v5ecg	210	4	Symposia	Symposia	NNP
cord-285091-2i2v5ecg	210	5	Pathogen	Pathogen	NNP
cord-285091-2i2v5ecg	210	6	recognition	recognition	NN
cord-285091-2i2v5ecg	210	7	and	and	CC
cord-285091-2i2v5ecg	210	8	innate	innate	JJ
cord-285091-2i2v5ecg	210	9	immunity	immunity	NN
cord-285091-2i2v5ecg	210	10	Toll	toll	NN
cord-285091-2i2v5ecg	210	11	-	-	HYPH
cord-285091-2i2v5ecg	210	12	like	like	JJ
cord-285091-2i2v5ecg	210	13	receptors	receptor	NNS
cord-285091-2i2v5ecg	210	14	and	and	CC
cord-285091-2i2v5ecg	210	15	their	-PRON-	PRP$
cord-285091-2i2v5ecg	210	16	crosstalk	crosstalk	NN
cord-285091-2i2v5ecg	210	17	with	with	IN
cord-285091-2i2v5ecg	210	18	other	other	JJ
cord-285091-2i2v5ecg	210	19	innate	innate	JJ
cord-285091-2i2v5ecg	210	20	receptors	receptor	NNS
cord-285091-2i2v5ecg	210	21	in	in	IN
cord-285091-2i2v5ecg	210	22	infection	infection	NN
cord-285091-2i2v5ecg	210	23	and	and	CC
cord-285091-2i2v5ecg	210	24	immunity	immunity	NN
cord-285091-2i2v5ecg	210	25	Toll	toll	NN
cord-285091-2i2v5ecg	210	26	-	-	HYPH
cord-285091-2i2v5ecg	210	27	like	like	JJ
cord-285091-2i2v5ecg	210	28	receptor	receptor	NN
cord-285091-2i2v5ecg	210	29	signalling	signal	VBG
cord-285091-2i2v5ecg	210	30	Recognition	recognition	NN
cord-285091-2i2v5ecg	210	31	of	of	IN
cord-285091-2i2v5ecg	210	32	microorganisms	microorganism	NNS
cord-285091-2i2v5ecg	210	33	and	and	CC
cord-285091-2i2v5ecg	210	34	activation	activation	NN
cord-285091-2i2v5ecg	210	35	of	of	IN
cord-285091-2i2v5ecg	210	36	the	the	DT
cord-285091-2i2v5ecg	210	37	immune	immune	JJ
cord-285091-2i2v5ecg	210	38	response	response	NN
cord-285091-2i2v5ecg	210	39	Structures	structure	NNS
cord-285091-2i2v5ecg	210	40	of	of	IN
cord-285091-2i2v5ecg	210	41	the	the	DT
cord-285091-2i2v5ecg	210	42	Toll	Toll	NNP
cord-285091-2i2v5ecg	210	43	-	-	HYPH
cord-285091-2i2v5ecg	210	44	like	like	JJ
cord-285091-2i2v5ecg	210	45	receptor	receptor	NN
cord-285091-2i2v5ecg	210	46	family	family	NN
cord-285091-2i2v5ecg	210	47	and	and	CC
cord-285091-2i2v5ecg	210	48	its	-PRON-	PRP$
cord-285091-2i2v5ecg	210	49	ligand	ligand	NN
cord-285091-2i2v5ecg	210	50	complexes	complex	NNS
cord-285091-2i2v5ecg	211	1	The	the	DT
cord-285091-2i2v5ecg	211	2	leucine	leucine	NN
cord-285091-2i2v5ecg	211	3	-	-	HYPH
cord-285091-2i2v5ecg	211	4	rich	rich	JJ
cord-285091-2i2v5ecg	211	5	repeat	repeat	NN
cord-285091-2i2v5ecg	211	6	as	as	IN
cord-285091-2i2v5ecg	211	7	a	a	DT
cord-285091-2i2v5ecg	211	8	protein	protein	NN
cord-285091-2i2v5ecg	211	9	recognition	recognition	NN
cord-285091-2i2v5ecg	211	10	motif	motif	NN
cord-285091-2i2v5ecg	211	11	Crystal	Crystal	NNP
cord-285091-2i2v5ecg	211	12	structure	structure	NN
cord-285091-2i2v5ecg	211	13	of	of	IN
cord-285091-2i2v5ecg	211	14	the	the	DT
cord-285091-2i2v5ecg	211	15	TLR1-TLR2	TLR1-TLR2	NNP
cord-285091-2i2v5ecg	211	16	heterodimer	heterodimer	NN
cord-285091-2i2v5ecg	211	17	induced	induce	VBN
cord-285091-2i2v5ecg	211	18	by	by	IN
cord-285091-2i2v5ecg	211	19	binding	bind	VBG
cord-285091-2i2v5ecg	211	20	of	of	IN
cord-285091-2i2v5ecg	211	21	a	a	DT
cord-285091-2i2v5ecg	211	22	tri	tri	JJ
cord-285091-2i2v5ecg	211	23	-	-	JJ
cord-285091-2i2v5ecg	211	24	acylated	acylated	JJ
cord-285091-2i2v5ecg	211	25	lipopeptide	lipopeptide	NNP
cord-285091-2i2v5ecg	212	1	The	the	DT
cord-285091-2i2v5ecg	212	2	role	role	NN
cord-285091-2i2v5ecg	212	3	of	of	IN
cord-285091-2i2v5ecg	212	4	pattern	pattern	NN
cord-285091-2i2v5ecg	212	5	-	-	HYPH
cord-285091-2i2v5ecg	212	6	recognition	recognition	NN
cord-285091-2i2v5ecg	212	7	receptors	receptor	NNS
cord-285091-2i2v5ecg	212	8	in	in	IN
cord-285091-2i2v5ecg	212	9	innate	innate	JJ
cord-285091-2i2v5ecg	212	10	immunity	immunity	NN
cord-285091-2i2v5ecg	212	11	:	:	:
cord-285091-2i2v5ecg	212	12	Update	update	VB
cord-285091-2i2v5ecg	212	13	on	on	IN
cord-285091-2i2v5ecg	212	14	toll	toll	NN
cord-285091-2i2v5ecg	212	15	-	-	HYPH
cord-285091-2i2v5ecg	212	16	like	like	JJ
cord-285091-2i2v5ecg	212	17	receptors	receptor	NNS
cord-285091-2i2v5ecg	213	1	A	a	DT
cord-285091-2i2v5ecg	213	2	human	human	JJ
cord-285091-2i2v5ecg	213	3	homologue	homologue	NN
cord-285091-2i2v5ecg	213	4	of	of	IN
cord-285091-2i2v5ecg	213	5	the	the	DT
cord-285091-2i2v5ecg	213	6	Drosophila	Drosophila	NNP
cord-285091-2i2v5ecg	213	7	toll	toll	NN
cord-285091-2i2v5ecg	213	8	protein	protein	NN
cord-285091-2i2v5ecg	213	9	signals	signal	VBZ
cord-285091-2i2v5ecg	213	10	activation	activation	NN
cord-285091-2i2v5ecg	213	11	of	of	IN
cord-285091-2i2v5ecg	213	12	adaptive	adaptive	JJ
cord-285091-2i2v5ecg	213	13	immunity	immunity	NN
cord-285091-2i2v5ecg	213	14	Crystal	Crystal	NNP
cord-285091-2i2v5ecg	213	15	structure	structure	NN
cord-285091-2i2v5ecg	213	16	of	of	IN
cord-285091-2i2v5ecg	213	17	the	the	DT
cord-285091-2i2v5ecg	213	18	TLR4-MD-2	TLR4-MD-2	NNP
cord-285091-2i2v5ecg	213	19	complex	complex	JJ
cord-285091-2i2v5ecg	213	20	with	with	IN
cord-285091-2i2v5ecg	213	21	bound	bind	VBN
cord-285091-2i2v5ecg	213	22	endotoxin	endotoxin	NN
cord-285091-2i2v5ecg	213	23	antagonist	antagonist	NN
cord-285091-2i2v5ecg	213	24	eritoran	eritoran	NN
cord-285091-2i2v5ecg	213	25	TLR4	TLR4	NNP
cord-285091-2i2v5ecg	213	26	as	as	IN
cord-285091-2i2v5ecg	213	27	the	the	DT
cord-285091-2i2v5ecg	213	28	mammalian	mammalian	JJ
cord-285091-2i2v5ecg	213	29	endotoxin	endotoxin	NN
cord-285091-2i2v5ecg	213	30	sensor	sensor	NN
cord-285091-2i2v5ecg	213	31	Defective	defective	JJ
cord-285091-2i2v5ecg	213	32	LPS	lp	NNS
cord-285091-2i2v5ecg	213	33	signaling	signal	VBG
cord-285091-2i2v5ecg	213	34	in	in	IN
cord-285091-2i2v5ecg	213	35	C3H	c3h	CD
cord-285091-2i2v5ecg	213	36	/	/	SYM
cord-285091-2i2v5ecg	213	37	Hej	Hej	NNP
cord-285091-2i2v5ecg	213	38	and	and	CC
cord-285091-2i2v5ecg	213	39	C57BL/10ScCr	c57bl/10sccr	JJ
cord-285091-2i2v5ecg	213	40	mice	mouse	NNS
cord-285091-2i2v5ecg	213	41	:	:	:
cord-285091-2i2v5ecg	214	1	Mutations	mutation	NNS
cord-285091-2i2v5ecg	214	2	in	in	IN
cord-285091-2i2v5ecg	214	3	Tlr4	Tlr4	NNP
cord-285091-2i2v5ecg	214	4	gene	gene	NN
cord-285091-2i2v5ecg	214	5	Peptidoglycan	Peptidoglycan	NNP
cord-285091-2i2v5ecg	214	6	-	-	HYPH
cord-285091-2i2v5ecg	214	7	and	and	CC
cord-285091-2i2v5ecg	214	8	lipoteichoic	lipoteichoic	JJ
cord-285091-2i2v5ecg	214	9	acid	acid	NN
cord-285091-2i2v5ecg	214	10	-	-	HYPH
cord-285091-2i2v5ecg	214	11	induced	induce	VBN
cord-285091-2i2v5ecg	214	12	cell	cell	NN
cord-285091-2i2v5ecg	214	13	activation	activation	NN
cord-285091-2i2v5ecg	214	14	is	be	VBZ
cord-285091-2i2v5ecg	214	15	mediated	mediate	VBN
cord-285091-2i2v5ecg	214	16	by	by	IN
cord-285091-2i2v5ecg	214	17	Toll	toll	NN
cord-285091-2i2v5ecg	214	18	-	-	HYPH
cord-285091-2i2v5ecg	214	19	like	like	JJ
cord-285091-2i2v5ecg	214	20	receptor	receptor	NN
cord-285091-2i2v5ecg	215	1	2	2	LS
cord-285091-2i2v5ecg	215	2	Toll	toll	NN
cord-285091-2i2v5ecg	215	3	-	-	HYPH
cord-285091-2i2v5ecg	215	4	like	like	JJ
cord-285091-2i2v5ecg	215	5	receptor-2	receptor-2	NNP
cord-285091-2i2v5ecg	215	6	mediates	mediate	VBZ
cord-285091-2i2v5ecg	215	7	mycobacteria	mycobacterium	NNS
cord-285091-2i2v5ecg	215	8	-	-	HYPH
cord-285091-2i2v5ecg	215	9	induced	induce	VBN
cord-285091-2i2v5ecg	215	10	proinflammatory	proinflammatory	JJ
cord-285091-2i2v5ecg	215	11	signaling	signaling	NN
cord-285091-2i2v5ecg	215	12	in	in	IN
cord-285091-2i2v5ecg	215	13	macrophages	macrophage	NNS
cord-285091-2i2v5ecg	215	14	Discrimination	discrimination	NN
cord-285091-2i2v5ecg	215	15	of	of	IN
cord-285091-2i2v5ecg	215	16	bacterial	bacterial	JJ
cord-285091-2i2v5ecg	215	17	lipoproteins	lipoprotein	NNS
cord-285091-2i2v5ecg	215	18	by	by	IN
cord-285091-2i2v5ecg	215	19	Toll	toll	NN
cord-285091-2i2v5ecg	215	20	-	-	HYPH
cord-285091-2i2v5ecg	215	21	like	like	JJ
cord-285091-2i2v5ecg	215	22	receptor	receptor	NN
cord-285091-2i2v5ecg	216	1	6	6	CD
cord-285091-2i2v5ecg	216	2	Tlr9	Tlr9	NNP
cord-285091-2i2v5ecg	216	3	signals	signal	NNS
cord-285091-2i2v5ecg	216	4	after	after	IN
cord-285091-2i2v5ecg	216	5	translocating	translocate	VBG
cord-285091-2i2v5ecg	216	6	from	from	IN
cord-285091-2i2v5ecg	216	7	the	the	DT
cord-285091-2i2v5ecg	216	8	er	er	NNP
cord-285091-2i2v5ecg	216	9	to	to	IN
cord-285091-2i2v5ecg	216	10	cpg	cpg	NNP
cord-285091-2i2v5ecg	216	11	DNA	DNA	NNP
cord-285091-2i2v5ecg	216	12	in	in	IN
cord-285091-2i2v5ecg	216	13	the	the	DT
cord-285091-2i2v5ecg	216	14	lysosome	lysosome	NN
cord-285091-2i2v5ecg	217	1	The	the	DT
cord-285091-2i2v5ecg	217	2	Unc93b1	unc93b1	NN
cord-285091-2i2v5ecg	217	3	mutation	mutation	NN
cord-285091-2i2v5ecg	217	4	3d	3d	NNP
cord-285091-2i2v5ecg	217	5	disrupts	disrupt	VBZ
cord-285091-2i2v5ecg	217	6	exogenous	exogenous	JJ
cord-285091-2i2v5ecg	217	7	antigen	antigen	NN
cord-285091-2i2v5ecg	217	8	presentation	presentation	NN
cord-285091-2i2v5ecg	217	9	and	and	CC
cord-285091-2i2v5ecg	217	10	signaling	signal	VBG
cord-285091-2i2v5ecg	217	11	via	via	IN
cord-285091-2i2v5ecg	217	12	Toll	toll	NN
cord-285091-2i2v5ecg	217	13	-	-	HYPH
cord-285091-2i2v5ecg	217	14	like	like	JJ
cord-285091-2i2v5ecg	217	15	receptors	receptor	NNS
cord-285091-2i2v5ecg	217	16	3	3	CD
cord-285091-2i2v5ecg	217	17	,	,	,
cord-285091-2i2v5ecg	217	18	7	7	CD
cord-285091-2i2v5ecg	217	19	and	and	CC
cord-285091-2i2v5ecg	217	20	9	9	CD
cord-285091-2i2v5ecg	217	21	Regulation	regulation	NN
cord-285091-2i2v5ecg	217	22	of	of	IN
cord-285091-2i2v5ecg	217	23	adaptive	adaptive	JJ
cord-285091-2i2v5ecg	217	24	immunity	immunity	NN
cord-285091-2i2v5ecg	217	25	by	by	IN
cord-285091-2i2v5ecg	217	26	the	the	DT
cord-285091-2i2v5ecg	217	27	innate	innate	JJ
cord-285091-2i2v5ecg	217	28	immune	immune	JJ
cord-285091-2i2v5ecg	217	29	system	system	NN
cord-285091-2i2v5ecg	218	1	The	the	DT
cord-285091-2i2v5ecg	218	2	database	database	NN
cord-285091-2i2v5ecg	218	3	of	of	IN
cord-285091-2i2v5ecg	218	4	proteolytic	proteolytic	JJ
cord-285091-2i2v5ecg	218	5	enzymes	enzyme	NNS
cord-285091-2i2v5ecg	218	6	,	,	,
cord-285091-2i2v5ecg	218	7	their	-PRON-	PRP$
cord-285091-2i2v5ecg	218	8	substrates	substrate	NNS
cord-285091-2i2v5ecg	218	9	and	and	CC
cord-285091-2i2v5ecg	218	10	inhibitors	inhibitor	NNS
cord-285091-2i2v5ecg	218	11	Cellular	cellular	JJ
cord-285091-2i2v5ecg	218	12	proteolysis	proteolysis	NN
cord-285091-2i2v5ecg	218	13	:	:	:
cord-285091-2i2v5ecg	218	14	An	an	DT
cord-285091-2i2v5ecg	218	15	overview	overview	NN
cord-285091-2i2v5ecg	218	16	Families	family	NNS
cord-285091-2i2v5ecg	218	17	of	of	IN
cord-285091-2i2v5ecg	218	18	cysteine	cysteine	NN
cord-285091-2i2v5ecg	218	19	peptidases	peptidase	NNS
cord-285091-2i2v5ecg	219	1	Cysteine	cysteine	NN
cord-285091-2i2v5ecg	219	2	cathepsins	cathepsin	NNS
cord-285091-2i2v5ecg	219	3	:	:	:
cord-285091-2i2v5ecg	219	4	From	from	IN
cord-285091-2i2v5ecg	219	5	structure	structure	NN
cord-285091-2i2v5ecg	219	6	,	,	,
cord-285091-2i2v5ecg	219	7	function	function	NN
cord-285091-2i2v5ecg	219	8	and	and	CC
cord-285091-2i2v5ecg	219	9	regulation	regulation	NN
cord-285091-2i2v5ecg	219	10	to	to	IN
cord-285091-2i2v5ecg	219	11	new	new	JJ
cord-285091-2i2v5ecg	219	12	frontiers	frontier	NNS
cord-285091-2i2v5ecg	219	13	Cysteine	Cysteine	NNP
cord-285091-2i2v5ecg	219	14	cathepsins	cathepsin	NNS
cord-285091-2i2v5ecg	219	15	:	:	:
cord-285091-2i2v5ecg	219	16	Cellular	cellular	JJ
cord-285091-2i2v5ecg	219	17	roadmap	roadmap	NN
cord-285091-2i2v5ecg	219	18	to	to	IN
cord-285091-2i2v5ecg	219	19	different	different	JJ
cord-285091-2i2v5ecg	219	20	functions	function	NNS
cord-285091-2i2v5ecg	220	1	Lysosomal	Lysosomal	NNP
cord-285091-2i2v5ecg	220	2	cysteine	cysteine	NN
cord-285091-2i2v5ecg	220	3	proteases	protease	NNS
cord-285091-2i2v5ecg	220	4	:	:	:
cord-285091-2i2v5ecg	220	5	Facts	fact	NNS
cord-285091-2i2v5ecg	220	6	and	and	CC
cord-285091-2i2v5ecg	220	7	opportunities	opportunity	NNS
cord-285091-2i2v5ecg	220	8	Towards	towards	IN
cord-285091-2i2v5ecg	220	9	specific	specific	JJ
cord-285091-2i2v5ecg	220	10	functions	function	NNS
cord-285091-2i2v5ecg	220	11	of	of	IN
cord-285091-2i2v5ecg	220	12	lysosomal	lysosomal	JJ
cord-285091-2i2v5ecg	220	13	cysteine	cysteine	NN
cord-285091-2i2v5ecg	220	14	peptidases	peptidase	NNS
cord-285091-2i2v5ecg	220	15	:	:	:
cord-285091-2i2v5ecg	220	16	Phenotypes	phenotype	NNS
cord-285091-2i2v5ecg	220	17	of	of	IN
cord-285091-2i2v5ecg	220	18	mice	mouse	NNS
cord-285091-2i2v5ecg	220	19	deficient	deficient	JJ
cord-285091-2i2v5ecg	220	20	for	for	IN
cord-285091-2i2v5ecg	220	21	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	220	22	B	b	NN
cord-285091-2i2v5ecg	220	23	or	or	CC
cord-285091-2i2v5ecg	220	24	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	220	25	L	L	NNP
cord-285091-2i2v5ecg	220	26	Human	Human	NNP
cord-285091-2i2v5ecg	220	27	and	and	CC
cord-285091-2i2v5ecg	220	28	mouse	mouse	NN
cord-285091-2i2v5ecg	220	29	proteases	protease	NNS
cord-285091-2i2v5ecg	220	30	:	:	:
cord-285091-2i2v5ecg	220	31	A	a	DT
cord-285091-2i2v5ecg	220	32	comparative	comparative	JJ
cord-285091-2i2v5ecg	220	33	genomic	genomic	NN
cord-285091-2i2v5ecg	220	34	approach	approach	NN
cord-285091-2i2v5ecg	220	35	López	López	NNP
cord-285091-2i2v5ecg	220	36	-	-	HYPH
cord-285091-2i2v5ecg	220	37	Otín	Otín	NNP
cord-285091-2i2v5ecg	220	38	,	,	,
cord-285091-2i2v5ecg	220	39	C.	C.	NNP
cord-285091-2i2v5ecg	220	40	Cathepsin	Cathepsin	NNP
cord-285091-2i2v5ecg	220	41	L2	L2	NNP
cord-285091-2i2v5ecg	220	42	,	,	,
cord-285091-2i2v5ecg	220	43	a	a	DT
cord-285091-2i2v5ecg	220	44	novel	novel	JJ
cord-285091-2i2v5ecg	220	45	human	human	JJ
cord-285091-2i2v5ecg	220	46	cysteine	cysteine	NN
cord-285091-2i2v5ecg	220	47	proteinase	proteinase	NN
cord-285091-2i2v5ecg	220	48	produced	produce	VBN
cord-285091-2i2v5ecg	220	49	by	by	IN
cord-285091-2i2v5ecg	220	50	breast	breast	NN
cord-285091-2i2v5ecg	220	51	and	and	CC
cord-285091-2i2v5ecg	220	52	colorectal	colorectal	JJ
cord-285091-2i2v5ecg	220	53	carcinomas	carcinoma	NNS
cord-285091-2i2v5ecg	220	54	Human	human	JJ
cord-285091-2i2v5ecg	220	55	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	220	56	v	v	LS
cord-285091-2i2v5ecg	220	57	functional	functional	JJ
cord-285091-2i2v5ecg	220	58	expression	expression	NN
cord-285091-2i2v5ecg	220	59	,	,	,
cord-285091-2i2v5ecg	220	60	tissue	tissue	NN
cord-285091-2i2v5ecg	220	61	distribution	distribution	NN
cord-285091-2i2v5ecg	220	62	,	,	,
cord-285091-2i2v5ecg	220	63	electrostatic	electrostatic	JJ
cord-285091-2i2v5ecg	220	64	surface	surface	NN
cord-285091-2i2v5ecg	220	65	potential	potential	NN
cord-285091-2i2v5ecg	220	66	,	,	,
cord-285091-2i2v5ecg	220	67	enzymatic	enzymatic	JJ
cord-285091-2i2v5ecg	220	68	characterization	characterization	NN
cord-285091-2i2v5ecg	220	69	,	,	,
cord-285091-2i2v5ecg	220	70	and	and	CC
cord-285091-2i2v5ecg	220	71	chromosomal	chromosomal	JJ
cord-285091-2i2v5ecg	220	72	localization	localization	NN
cord-285091-2i2v5ecg	221	1	A	a	DT
cord-285091-2i2v5ecg	221	2	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	221	3	L	l	NN
cord-285091-2i2v5ecg	221	4	isoform	isoform	NN
cord-285091-2i2v5ecg	221	5	that	that	WDT
cord-285091-2i2v5ecg	221	6	is	be	VBZ
cord-285091-2i2v5ecg	221	7	devoid	devoid	JJ
cord-285091-2i2v5ecg	221	8	of	of	IN
cord-285091-2i2v5ecg	221	9	a	a	DT
cord-285091-2i2v5ecg	221	10	signal	signal	JJ
cord-285091-2i2v5ecg	221	11	peptide	peptide	NN
cord-285091-2i2v5ecg	221	12	localizes	localize	VBZ
cord-285091-2i2v5ecg	221	13	to	to	IN
cord-285091-2i2v5ecg	221	14	the	the	DT
cord-285091-2i2v5ecg	221	15	nucleus	nucleus	NN
cord-285091-2i2v5ecg	221	16	in	in	IN
cord-285091-2i2v5ecg	221	17	s	s	POS
cord-285091-2i2v5ecg	221	18	phase	phase	NN
cord-285091-2i2v5ecg	221	19	and	and	CC
cord-285091-2i2v5ecg	221	20	processes	process	VBZ
cord-285091-2i2v5ecg	221	21	the	the	DT
cord-285091-2i2v5ecg	221	22	CDP	CDP	NNP
cord-285091-2i2v5ecg	221	23	/	/	SYM
cord-285091-2i2v5ecg	221	24	Cux	Cux	NNP
cord-285091-2i2v5ecg	221	25	transcription	transcription	NN
cord-285091-2i2v5ecg	221	26	factor	factor	NN
cord-285091-2i2v5ecg	222	1	In	in	IN
cord-285091-2i2v5ecg	222	2	vivo	vivo	NN
cord-285091-2i2v5ecg	222	3	expression	expression	NN
cord-285091-2i2v5ecg	222	4	of	of	IN
cord-285091-2i2v5ecg	222	5	an	an	DT
cord-285091-2i2v5ecg	222	6	alternatively	alternatively	RB
cord-285091-2i2v5ecg	222	7	spliced	splice	VBN
cord-285091-2i2v5ecg	222	8	human	human	JJ
cord-285091-2i2v5ecg	222	9	tumor	tumor	NN
cord-285091-2i2v5ecg	222	10	message	message	NN
cord-285091-2i2v5ecg	222	11	that	that	WDT
cord-285091-2i2v5ecg	222	12	encodes	encode	VBZ
cord-285091-2i2v5ecg	222	13	a	a	DT
cord-285091-2i2v5ecg	222	14	truncated	truncated	JJ
cord-285091-2i2v5ecg	222	15	form	form	NN
cord-285091-2i2v5ecg	222	16	of	of	IN
cord-285091-2i2v5ecg	222	17	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	222	18	B	b	NN
cord-285091-2i2v5ecg	223	1	Nuclear	nuclear	JJ
cord-285091-2i2v5ecg	223	2	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	223	3	F	F	NNP
cord-285091-2i2v5ecg	223	4	regulates	regulate	VBZ
cord-285091-2i2v5ecg	223	5	activation	activation	NN
cord-285091-2i2v5ecg	223	6	markers	marker	NNS
cord-285091-2i2v5ecg	223	7	in	in	IN
cord-285091-2i2v5ecg	223	8	rat	rat	NN
cord-285091-2i2v5ecg	223	9	hepatic	hepatic	JJ
cord-285091-2i2v5ecg	223	10	stellate	stellate	JJ
cord-285091-2i2v5ecg	223	11	cells	cell	NNS
cord-285091-2i2v5ecg	223	12	Nuclear	nuclear	JJ
cord-285091-2i2v5ecg	223	13	cysteine	cysteine	NN
cord-285091-2i2v5ecg	223	14	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	223	15	variants	variant	NNS
cord-285091-2i2v5ecg	223	16	in	in	IN
cord-285091-2i2v5ecg	223	17	thyroid	thyroid	NN
cord-285091-2i2v5ecg	223	18	carcinoma	carcinoma	NN
cord-285091-2i2v5ecg	223	19	cells	cell	VBZ
cord-285091-2i2v5ecg	223	20	Kopitar	Kopitar	NNP
cord-285091-2i2v5ecg	223	21	-	-	HYPH
cord-285091-2i2v5ecg	223	22	Jerala	Jerala	NNP
cord-285091-2i2v5ecg	224	1	,	,	,
cord-285091-2i2v5ecg	224	2	N.	N.	NNP
cord-285091-2i2v5ecg	224	3	Stefin	Stefin	NNP
cord-285091-2i2v5ecg	224	4	b	b	NNP
cord-285091-2i2v5ecg	224	5	interacts	interact	VBZ
cord-285091-2i2v5ecg	224	6	with	with	IN
cord-285091-2i2v5ecg	224	7	histones	histone	NNS
cord-285091-2i2v5ecg	224	8	and	and	CC
cord-285091-2i2v5ecg	224	9	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	224	10	l	l	NN
cord-285091-2i2v5ecg	224	11	in	in	IN
cord-285091-2i2v5ecg	224	12	the	the	DT
cord-285091-2i2v5ecg	224	13	nucleus	nucleus	NN
cord-285091-2i2v5ecg	224	14	Cystatins	Cystatins	NNP
cord-285091-2i2v5ecg	224	15	:	:	:
cord-285091-2i2v5ecg	224	16	Biochemical	biochemical	JJ
cord-285091-2i2v5ecg	224	17	and	and	CC
cord-285091-2i2v5ecg	224	18	structural	structural	JJ
cord-285091-2i2v5ecg	224	19	properties	property	NNS
cord-285091-2i2v5ecg	224	20	,	,	,
cord-285091-2i2v5ecg	224	21	and	and	CC
cord-285091-2i2v5ecg	224	22	medical	medical	JJ
cord-285091-2i2v5ecg	224	23	relevance	relevance	NN
cord-285091-2i2v5ecg	225	1	The	the	DT
cord-285091-2i2v5ecg	225	2	role	role	NN
cord-285091-2i2v5ecg	225	3	of	of	IN
cord-285091-2i2v5ecg	225	4	cystatins	cystatin	NNS
cord-285091-2i2v5ecg	225	5	in	in	IN
cord-285091-2i2v5ecg	225	6	cells	cell	NNS
cord-285091-2i2v5ecg	225	7	of	of	IN
cord-285091-2i2v5ecg	225	8	the	the	DT
cord-285091-2i2v5ecg	225	9	immune	immune	JJ
cord-285091-2i2v5ecg	225	10	system	system	NN
cord-285091-2i2v5ecg	225	11	Thyropins	Thyropins	NNP
cord-285091-2i2v5ecg	225	12	mdash	mdash	NN
cord-285091-2i2v5ecg	225	13	new	new	RB
cord-285091-2i2v5ecg	225	14	structurally	structurally	RB
cord-285091-2i2v5ecg	225	15	related	related	JJ
cord-285091-2i2v5ecg	225	16	proteinase	proteinase	NN
cord-285091-2i2v5ecg	225	17	inhibitors	inhibitor	NNS
cord-285091-2i2v5ecg	225	18	Cross	Cross	NNP
cord-285091-2i2v5ecg	225	19	-	-	HYPH
cord-285091-2i2v5ecg	225	20	class	class	NN
cord-285091-2i2v5ecg	225	21	inhibition	inhibition	NN
cord-285091-2i2v5ecg	225	22	of	of	IN
cord-285091-2i2v5ecg	225	23	the	the	DT
cord-285091-2i2v5ecg	225	24	cysteine	cysteine	NN
cord-285091-2i2v5ecg	225	25	proteinases	proteinases	NNP
cord-285091-2i2v5ecg	225	26	cathepsins	cathepsins	NNPS
cord-285091-2i2v5ecg	225	27	K	K	NNP
cord-285091-2i2v5ecg	225	28	,	,	,
cord-285091-2i2v5ecg	225	29	L	L	NNP
cord-285091-2i2v5ecg	225	30	,	,	,
cord-285091-2i2v5ecg	225	31	and	and	CC
cord-285091-2i2v5ecg	225	32	S	S	NNP
cord-285091-2i2v5ecg	225	33	by	by	IN
cord-285091-2i2v5ecg	225	34	the	the	DT
cord-285091-2i2v5ecg	225	35	serpin	serpin	JJ
cord-285091-2i2v5ecg	225	36	squamous	squamous	JJ
cord-285091-2i2v5ecg	225	37	cell	cell	NN
cord-285091-2i2v5ecg	225	38	carcinoma	carcinoma	NN
cord-285091-2i2v5ecg	225	39	antigen	antigen	NN
cord-285091-2i2v5ecg	225	40	1	1	CD
cord-285091-2i2v5ecg	225	41	:	:	:
cord-285091-2i2v5ecg	225	42	A	a	DT
cord-285091-2i2v5ecg	225	43	kinetic	kinetic	JJ
cord-285091-2i2v5ecg	225	44	analysis	analysis	NN
cord-285091-2i2v5ecg	225	45	†	†	NN
cord-285091-2i2v5ecg	225	46	Major	major	JJ
cord-285091-2i2v5ecg	225	47	histocompatibility	histocompatibility	NN
cord-285091-2i2v5ecg	225	48	complex	complex	JJ
cord-285091-2i2v5ecg	225	49	class	class	NN
cord-285091-2i2v5ecg	225	50	Ii	Ii	NNP
cord-285091-2i2v5ecg	225	51	-	-	HYPH
cord-285091-2i2v5ecg	225	52	associated	associate	VBN
cord-285091-2i2v5ecg	225	53	p41	p41	NN
cord-285091-2i2v5ecg	225	54	invariant	invariant	JJ
cord-285091-2i2v5ecg	225	55	chain	chain	NN
cord-285091-2i2v5ecg	225	56	fragment	fragment	NN
cord-285091-2i2v5ecg	225	57	is	be	VBZ
cord-285091-2i2v5ecg	225	58	a	a	DT
cord-285091-2i2v5ecg	225	59	strong	strong	JJ
cord-285091-2i2v5ecg	225	60	inhibitor	inhibitor	NN
cord-285091-2i2v5ecg	225	61	of	of	IN
cord-285091-2i2v5ecg	225	62	lysosomal	lysosomal	JJ
cord-285091-2i2v5ecg	225	63	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	225	64	L	L	NNP
cord-285091-2i2v5ecg	225	65	A	A	NNP
cord-285091-2i2v5ecg	225	66	fragment	fragment	NN
cord-285091-2i2v5ecg	225	67	of	of	IN
cord-285091-2i2v5ecg	225	68	the	the	DT
cord-285091-2i2v5ecg	225	69	major	major	JJ
cord-285091-2i2v5ecg	225	70	histocompatibility	histocompatibility	NN
cord-285091-2i2v5ecg	225	71	complex	complex	JJ
cord-285091-2i2v5ecg	225	72	class	class	NN
cord-285091-2i2v5ecg	225	73	Iiassociated	Iiassociated	NNP
cord-285091-2i2v5ecg	225	74	p41	p41	NN
cord-285091-2i2v5ecg	225	75	invariant	invariant	JJ
cord-285091-2i2v5ecg	225	76	chain	chain	NN
cord-285091-2i2v5ecg	225	77	inhibits	inhibit	VBZ
cord-285091-2i2v5ecg	225	78	cruzipain	cruzipain	NN
cord-285091-2i2v5ecg	225	79	,	,	,
cord-285091-2i2v5ecg	225	80	the	the	DT
cord-285091-2i2v5ecg	225	81	major	major	JJ
cord-285091-2i2v5ecg	225	82	cysteine	cysteine	NN
cord-285091-2i2v5ecg	225	83	proteinase	proteinase	NN
cord-285091-2i2v5ecg	225	84	from	from	IN
cord-285091-2i2v5ecg	225	85	trypanosoma	trypanosoma	NNP
cord-285091-2i2v5ecg	225	86	cruzi	cruzi	NNP
cord-285091-2i2v5ecg	225	87	Crystal	Crystal	NNP
cord-285091-2i2v5ecg	225	88	structure	structure	NN
cord-285091-2i2v5ecg	225	89	of	of	IN
cord-285091-2i2v5ecg	225	90	mhc	mhc	NNP
cord-285091-2i2v5ecg	225	91	class	class	NNP
cord-285091-2i2v5ecg	225	92	Ii	Ii	NNP
cord-285091-2i2v5ecg	225	93	-	-	HYPH
cord-285091-2i2v5ecg	225	94	associated	associated	NNP
cord-285091-2i2v5ecg	225	95	p41	p41	NNP
cord-285091-2i2v5ecg	225	96	ii	ii	NN
cord-285091-2i2v5ecg	225	97	fragment	fragment	NN
cord-285091-2i2v5ecg	225	98	bound	bind	VBN
cord-285091-2i2v5ecg	225	99	to	to	IN
cord-285091-2i2v5ecg	226	1	cathepsin	cathepsin	NNP
cord-285091-2i2v5ecg	226	2	l	l	NNP
cord-285091-2i2v5ecg	226	3	reveals	reveal	VBZ
cord-285091-2i2v5ecg	226	4	the	the	DT
cord-285091-2i2v5ecg	226	5	structural	structural	JJ
cord-285091-2i2v5ecg	226	6	basis	basis	NN
cord-285091-2i2v5ecg	226	7	for	for	IN
cord-285091-2i2v5ecg	226	8	differentiation	differentiation	NN
cord-285091-2i2v5ecg	226	9	between	between	IN
cord-285091-2i2v5ecg	226	10	cathepsins	cathepsin	NNS
cord-285091-2i2v5ecg	226	11	L	L	NNP
cord-285091-2i2v5ecg	226	12	and	and	CC
cord-285091-2i2v5ecg	226	13	S	S	NNP
cord-285091-2i2v5ecg	226	14	Nomenclature	Nomenclature	NNP
cord-285091-2i2v5ecg	226	15	and	and	CC
cord-285091-2i2v5ecg	226	16	classification	classification	NN
cord-285091-2i2v5ecg	226	17	of	of	IN
cord-285091-2i2v5ecg	226	18	the	the	DT
cord-285091-2i2v5ecg	226	19	proteins	protein	NNS
cord-285091-2i2v5ecg	226	20	homologous	homologous	JJ
cord-285091-2i2v5ecg	226	21	with	with	IN
cord-285091-2i2v5ecg	226	22	the	the	DT
cord-285091-2i2v5ecg	226	23	cysteine	cysteine	NN
cord-285091-2i2v5ecg	226	24	-	-	HYPH
cord-285091-2i2v5ecg	226	25	proteinase	proteinase	NN
cord-285091-2i2v5ecg	226	26	inhibitor	inhibitor	NN
cord-285091-2i2v5ecg	226	27	chicken	chicken	NN
cord-285091-2i2v5ecg	226	28	cystatin	cystatin	NNP
cord-285091-2i2v5ecg	227	1	The	the	DT
cord-285091-2i2v5ecg	227	2	2.0	2.0	CD
cord-285091-2i2v5ecg	227	3	A	a	NN
cord-285091-2i2v5ecg	227	4	x	x	NN
cord-285091-2i2v5ecg	227	5	-	-	NN
cord-285091-2i2v5ecg	227	6	ray	ray	NN
cord-285091-2i2v5ecg	227	7	crystal	crystal	NN
cord-285091-2i2v5ecg	227	8	structure	structure	NN
cord-285091-2i2v5ecg	227	9	of	of	IN
cord-285091-2i2v5ecg	227	10	chicken	chicken	NNP
cord-285091-2i2v5ecg	227	11	egg	egg	NN
cord-285091-2i2v5ecg	227	12	white	white	NNP
cord-285091-2i2v5ecg	227	13	cystatin	cystatin	NNP
cord-285091-2i2v5ecg	227	14	and	and	CC
cord-285091-2i2v5ecg	227	15	its	-PRON-	PRP$
cord-285091-2i2v5ecg	227	16	possible	possible	JJ
cord-285091-2i2v5ecg	227	17	mode	mode	NN
cord-285091-2i2v5ecg	227	18	of	of	IN
cord-285091-2i2v5ecg	227	19	interaction	interaction	NN
cord-285091-2i2v5ecg	227	20	with	with	IN
cord-285091-2i2v5ecg	227	21	cysteine	cysteine	NN
cord-285091-2i2v5ecg	227	22	proteinases	proteinase	NNS
cord-285091-2i2v5ecg	228	1	The	the	DT
cord-285091-2i2v5ecg	228	2	refined	refined	JJ
cord-285091-2i2v5ecg	228	3	2.4	2.4	CD
cord-285091-2i2v5ecg	228	4	A	a	DT
cord-285091-2i2v5ecg	228	5	X	x	NN
cord-285091-2i2v5ecg	228	6	-	-	NN
cord-285091-2i2v5ecg	228	7	ray	ray	NN
cord-285091-2i2v5ecg	228	8	crystal	crystal	NN
cord-285091-2i2v5ecg	228	9	structure	structure	NN
cord-285091-2i2v5ecg	228	10	of	of	IN
cord-285091-2i2v5ecg	228	11	recombinant	recombinant	JJ
cord-285091-2i2v5ecg	228	12	human	human	NNP
cord-285091-2i2v5ecg	228	13	stefin	stefin	NNP
cord-285091-2i2v5ecg	228	14	B	B	NNP
cord-285091-2i2v5ecg	228	15	in	in	IN
cord-285091-2i2v5ecg	228	16	complex	complex	NN
cord-285091-2i2v5ecg	228	17	with	with	IN
cord-285091-2i2v5ecg	228	18	the	the	DT
cord-285091-2i2v5ecg	228	19	cysteine	cysteine	NN
cord-285091-2i2v5ecg	228	20	proteinase	proteinase	NN
cord-285091-2i2v5ecg	228	21	papain	papain	NN
cord-285091-2i2v5ecg	228	22	:	:	:
cord-285091-2i2v5ecg	229	1	A	a	DT
cord-285091-2i2v5ecg	229	2	novel	novel	JJ
cord-285091-2i2v5ecg	229	3	type	type	NN
cord-285091-2i2v5ecg	229	4	of	of	IN
cord-285091-2i2v5ecg	229	5	proteinase	proteinase	NN
cord-285091-2i2v5ecg	229	6	inhibitor	inhibitor	NN
cord-285091-2i2v5ecg	229	7	interaction	interaction	NN
cord-285091-2i2v5ecg	229	8	Human	Human	NNP
cord-285091-2i2v5ecg	229	9	low	low	JJ
cord-285091-2i2v5ecg	229	10	-	-	HYPH
cord-285091-2i2v5ecg	229	11	mr	mr	NNP
cord-285091-2i2v5ecg	229	12	kininogen	kininogen	NNP
cord-285091-2i2v5ecg	229	13	contains	contain	VBZ
cord-285091-2i2v5ecg	229	14	three	three	CD
cord-285091-2i2v5ecg	229	15	copies	copy	NNS
cord-285091-2i2v5ecg	229	16	of	of	IN
cord-285091-2i2v5ecg	229	17	a	a	DT
cord-285091-2i2v5ecg	229	18	cystatin	cystatin	JJ
cord-285091-2i2v5ecg	229	19	sequence	sequence	NN
cord-285091-2i2v5ecg	229	20	that	that	WDT
cord-285091-2i2v5ecg	229	21	are	be	VBP
cord-285091-2i2v5ecg	229	22	divergent	divergent	JJ
cord-285091-2i2v5ecg	229	23	in	in	IN
cord-285091-2i2v5ecg	229	24	structure	structure	NN
cord-285091-2i2v5ecg	229	25	and	and	CC
cord-285091-2i2v5ecg	229	26	in	in	IN
cord-285091-2i2v5ecg	229	27	inhibitory	inhibitory	JJ
cord-285091-2i2v5ecg	229	28	activity	activity	NN
cord-285091-2i2v5ecg	229	29	for	for	IN
cord-285091-2i2v5ecg	229	30	cysteine	cysteine	NN
cord-285091-2i2v5ecg	229	31	proteinases	proteinases	NNP
cord-285091-2i2v5ecg	229	32	Isolation	Isolation	NNP
cord-285091-2i2v5ecg	229	33	of	of	IN
cord-285091-2i2v5ecg	229	34	a	a	DT
cord-285091-2i2v5ecg	229	35	human	human	JJ
cord-285091-2i2v5ecg	229	36	cDNA	cdna	NN
cord-285091-2i2v5ecg	229	37	for	for	IN
cord-285091-2i2v5ecg	229	38	alpha	alpha	NN
cord-285091-2i2v5ecg	229	39	2-thiol	2-thiol	CD
cord-285091-2i2v5ecg	229	40	proteinase	proteinase	NN
cord-285091-2i2v5ecg	229	41	inhibitor	inhibitor	NN
cord-285091-2i2v5ecg	229	42	and	and	CC
cord-285091-2i2v5ecg	229	43	its	-PRON-	PRP$
cord-285091-2i2v5ecg	229	44	identity	identity	NN
cord-285091-2i2v5ecg	229	45	with	with	IN
cord-285091-2i2v5ecg	229	46	low	low	JJ
cord-285091-2i2v5ecg	229	47	molecular	molecular	JJ
cord-285091-2i2v5ecg	229	48	weight	weight	NN
cord-285091-2i2v5ecg	229	49	kininogen	kininogen	NNP
cord-285091-2i2v5ecg	230	1	The	the	DT
cord-285091-2i2v5ecg	230	2	serpins	serpin	NNS
cord-285091-2i2v5ecg	230	3	are	be	VBP
cord-285091-2i2v5ecg	230	4	an	an	DT
cord-285091-2i2v5ecg	230	5	expanding	expand	VBG
cord-285091-2i2v5ecg	230	6	superfamily	superfamily	NN
cord-285091-2i2v5ecg	230	7	of	of	IN
cord-285091-2i2v5ecg	230	8	structurally	structurally	RB
cord-285091-2i2v5ecg	230	9	similar	similar	JJ
cord-285091-2i2v5ecg	230	10	but	but	CC
cord-285091-2i2v5ecg	230	11	functionally	functionally	RB
cord-285091-2i2v5ecg	230	12	diverse	diverse	JJ
cord-285091-2i2v5ecg	230	13	proteins	protein	NNS
cord-285091-2i2v5ecg	230	14	Structure	Structure	NNP
cord-285091-2i2v5ecg	230	15	of	of	IN
cord-285091-2i2v5ecg	230	16	a	a	DT
cord-285091-2i2v5ecg	230	17	serpinprotease	serpinprotease	JJ
cord-285091-2i2v5ecg	230	18	complex	complex	NN
cord-285091-2i2v5ecg	230	19	shows	show	VBZ
cord-285091-2i2v5ecg	230	20	inhibition	inhibition	NN
cord-285091-2i2v5ecg	230	21	by	by	IN
cord-285091-2i2v5ecg	230	22	deformation	deformation	NN
cord-285091-2i2v5ecg	230	23	The	the	DT
cord-285091-2i2v5ecg	230	24	serpin	serpin	NN
cord-285091-2i2v5ecg	230	25	SQN-5	SQN-5	NNPS
cord-285091-2i2v5ecg	230	26	is	be	VBZ
cord-285091-2i2v5ecg	230	27	a	a	DT
cord-285091-2i2v5ecg	230	28	dual	dual	JJ
cord-285091-2i2v5ecg	230	29	mechanistic	mechanistic	JJ
cord-285091-2i2v5ecg	230	30	-	-	HYPH
cord-285091-2i2v5ecg	230	31	class	class	NN
cord-285091-2i2v5ecg	230	32	inhibitor	inhibitor	NN
cord-285091-2i2v5ecg	230	33	of	of	IN
cord-285091-2i2v5ecg	230	34	serine	serine	NN
cord-285091-2i2v5ecg	230	35	and	and	CC
cord-285091-2i2v5ecg	230	36	cysteine	cysteine	NN
cord-285091-2i2v5ecg	230	37	proteinases	proteinase	NNS
cord-285091-2i2v5ecg	231	1	Caspase-1	Caspase-1	NNP
cord-285091-2i2v5ecg	231	2	(	(	-LRB-
cord-285091-2i2v5ecg	231	3	interleukin-1beta	interleukin-1beta	RB
cord-285091-2i2v5ecg	231	4	-	-	HYPH
cord-285091-2i2v5ecg	231	5	converting	convert	VBG
cord-285091-2i2v5ecg	231	6	enzyme	enzyme	NN
cord-285091-2i2v5ecg	231	7	)	)	-RRB-
cord-285091-2i2v5ecg	231	8	is	be	VBZ
cord-285091-2i2v5ecg	231	9	inhibited	inhibit	VBN
cord-285091-2i2v5ecg	231	10	by	by	IN
cord-285091-2i2v5ecg	231	11	the	the	DT
cord-285091-2i2v5ecg	231	12	human	human	JJ
cord-285091-2i2v5ecg	231	13	serpin	serpin	NN
cord-285091-2i2v5ecg	231	14	analogue	analogue	NN
cord-285091-2i2v5ecg	231	15	proteinase	proteinase	NN
cord-285091-2i2v5ecg	231	16	inhibitor	inhibitor	NN
cord-285091-2i2v5ecg	231	17	9	9	CD
cord-285091-2i2v5ecg	231	18	Inhibition	inhibition	NN
cord-285091-2i2v5ecg	231	19	of	of	IN
cord-285091-2i2v5ecg	231	20	interleukin-1	interleukin-1	NN
cord-285091-2i2v5ecg	231	21	beta	beta	NN
cord-285091-2i2v5ecg	231	22	converting	convert	VBG
cord-285091-2i2v5ecg	231	23	enzyme	enzyme	NN
cord-285091-2i2v5ecg	231	24	by	by	IN
cord-285091-2i2v5ecg	231	25	the	the	DT
cord-285091-2i2v5ecg	231	26	cowpox	cowpox	NN
cord-285091-2i2v5ecg	231	27	virus	virus	NN
cord-285091-2i2v5ecg	231	28	serpin	serpin	NN
cord-285091-2i2v5ecg	231	29	CrmA.	CrmA.	NNP
cord-285091-2i2v5ecg	232	1	An	an	DT
cord-285091-2i2v5ecg	232	2	example	example	NN
cord-285091-2i2v5ecg	232	3	of	of	IN
cord-285091-2i2v5ecg	232	4	cross	cross	JJ
cord-285091-2i2v5ecg	232	5	-	-	JJ
cord-285091-2i2v5ecg	232	6	class	class	JJ
cord-285091-2i2v5ecg	232	7	inhibition	inhibition	NN
cord-285091-2i2v5ecg	232	8	Nf-[kappa]b	Nf-[kappa]b	VBZ
cord-285091-2i2v5ecg	232	9	protects	protect	VBZ
cord-285091-2i2v5ecg	232	10	from	from	IN
cord-285091-2i2v5ecg	232	11	the	the	DT
cord-285091-2i2v5ecg	232	12	lysosomal	lysosomal	JJ
cord-285091-2i2v5ecg	232	13	pathway	pathway	NN
cord-285091-2i2v5ecg	232	14	of	of	IN
cord-285091-2i2v5ecg	232	15	cell	cell	NN
cord-285091-2i2v5ecg	232	16	death	death	NN
cord-285091-2i2v5ecg	232	17	Monocyte	Monocyte	NNP
cord-285091-2i2v5ecg	232	18	and	and	CC
cord-285091-2i2v5ecg	232	19	macrophage	macrophage	NN
cord-285091-2i2v5ecg	232	20	heterogeneity	heterogeneity	NN
cord-285091-2i2v5ecg	232	21	Macrophage	macrophage	NN
cord-285091-2i2v5ecg	232	22	activation	activation	NN
cord-285091-2i2v5ecg	232	23	and	and	CC
cord-285091-2i2v5ecg	232	24	polarization	polarization	NN
cord-285091-2i2v5ecg	232	25	Microbial	microbial	JJ
cord-285091-2i2v5ecg	232	26	manipulation	manipulation	NN
cord-285091-2i2v5ecg	232	27	of	of	IN
cord-285091-2i2v5ecg	232	28	receptor	receptor	NN
cord-285091-2i2v5ecg	232	29	crosstalk	crosstalk	NN
cord-285091-2i2v5ecg	232	30	in	in	IN
cord-285091-2i2v5ecg	232	31	innate	innate	JJ
cord-285091-2i2v5ecg	232	32	immunity	immunity	NN
cord-285091-2i2v5ecg	232	33	Obstacles	obstacle	NNS
cord-285091-2i2v5ecg	232	34	and	and	CC
cord-285091-2i2v5ecg	232	35	opportunities	opportunity	NNS
cord-285091-2i2v5ecg	232	36	for	for	IN
cord-285091-2i2v5ecg	232	37	understanding	understand	VBG
cord-285091-2i2v5ecg	232	38	macrophage	macrophage	NN
cord-285091-2i2v5ecg	232	39	polarization	polarization	NN
cord-285091-2i2v5ecg	232	40	Blood	blood	NN
cord-285091-2i2v5ecg	232	41	monocytes	monocyte	NNS
cord-285091-2i2v5ecg	232	42	consist	consist	VBP
cord-285091-2i2v5ecg	232	43	of	of	IN
cord-285091-2i2v5ecg	232	44	two	two	CD
cord-285091-2i2v5ecg	232	45	principal	principal	JJ
cord-285091-2i2v5ecg	232	46	subsets	subset	NNS
cord-285091-2i2v5ecg	232	47	with	with	IN
cord-285091-2i2v5ecg	232	48	distinct	distinct	JJ
cord-285091-2i2v5ecg	232	49	migratory	migratory	JJ
cord-285091-2i2v5ecg	232	50	properties	property	NNS
cord-285091-2i2v5ecg	232	51	Selective	selective	JJ
cord-285091-2i2v5ecg	232	52	suppression	suppression	NN
cord-285091-2i2v5ecg	232	53	of	of	IN
cord-285091-2i2v5ecg	232	54	interleukin-12	interleukin-12	CD
cord-285091-2i2v5ecg	232	55	induction	induction	NN
cord-285091-2i2v5ecg	232	56	after	after	IN
cord-285091-2i2v5ecg	232	57	macrophage	macrophage	NN
cord-285091-2i2v5ecg	232	58	receptor	receptor	NN
cord-285091-2i2v5ecg	232	59	ligation	ligation	NN
cord-285091-2i2v5ecg	233	1	The	the	DT
cord-285091-2i2v5ecg	233	2	regulation	regulation	NN
cord-285091-2i2v5ecg	233	3	of	of	IN
cord-285091-2i2v5ecg	233	4	IL-10	IL-10	NNP
cord-285091-2i2v5ecg	233	5	production	production	NN
cord-285091-2i2v5ecg	233	6	by	by	IN
cord-285091-2i2v5ecg	233	7	immune	immune	JJ
cord-285091-2i2v5ecg	233	8	cells	cell	NNS
cord-285091-2i2v5ecg	233	9	Cystatins	cystatin	VBZ
cord-285091-2i2v5ecg	233	10	up	up	RB
cord-285091-2i2v5ecg	233	11	-	-	HYPH
cord-285091-2i2v5ecg	233	12	regulate	regulate	VB
cord-285091-2i2v5ecg	233	13	nitric	nitric	NN
cord-285091-2i2v5ecg	233	14	oxide	oxide	NN
cord-285091-2i2v5ecg	233	15	release	release	NN
cord-285091-2i2v5ecg	233	16	from	from	IN
cord-285091-2i2v5ecg	233	17	interferon	interferon	NN
cord-285091-2i2v5ecg	233	18	--	--	:
cord-285091-2i2v5ecg	233	19	activated	activate	VBN
cord-285091-2i2v5ecg	233	20	mouse	mouse	NN
cord-285091-2i2v5ecg	233	21	peritoneal	peritoneal	NN
cord-285091-2i2v5ecg	233	22	macrophages	macrophage	NNS
cord-285091-2i2v5ecg	234	1	Chicken	chicken	NN
cord-285091-2i2v5ecg	234	2	cystatin	cystatin	NN
cord-285091-2i2v5ecg	234	3	stimulates	stimulate	VBZ
cord-285091-2i2v5ecg	234	4	nitric	nitric	NN
cord-285091-2i2v5ecg	234	5	oxide	oxide	NN
cord-285091-2i2v5ecg	234	6	release	release	NN
cord-285091-2i2v5ecg	234	7	from	from	IN
cord-285091-2i2v5ecg	234	8	interferon	interferon	NN
cord-285091-2i2v5ecg	234	9	--	--	:
cord-285091-2i2v5ecg	234	10	activated	activate	VBN
cord-285091-2i2v5ecg	234	11	mouse	mouse	NN
cord-285091-2i2v5ecg	234	12	peritoneal	peritoneal	NN
cord-285091-2i2v5ecg	234	13	macrophages	macrophage	NNS
cord-285091-2i2v5ecg	234	14	via	via	IN
cord-285091-2i2v5ecg	234	15	cytokine	cytokine	NN
cord-285091-2i2v5ecg	234	16	synthesis	synthesis	NN
cord-285091-2i2v5ecg	234	17	Macrophage	macrophage	NN
cord-285091-2i2v5ecg	234	18	responses	response	NNS
cord-285091-2i2v5ecg	234	19	to	to	IN
cord-285091-2i2v5ecg	234	20	interferon	interferon	NN
cord-285091-2i2v5ecg	234	21	-	-	:
cord-285091-2i2v5ecg	234	22	are	be	VBP
cord-285091-2i2v5ecg	234	23	dependent	dependent	JJ
cord-285091-2i2v5ecg	234	24	on	on	IN
cord-285091-2i2v5ecg	234	25	cystatin	cystatin	NN
cord-285091-2i2v5ecg	234	26	C	c	NN
cord-285091-2i2v5ecg	234	27	levels	level	NNS
cord-285091-2i2v5ecg	234	28	.	.	.
cord-285091-2i2v5ecg	235	1	Intern	Intern	NNP
cord-285091-2i2v5ecg	235	2	The	the	DT
cord-285091-2i2v5ecg	235	3	lysosomal	lysosomal	JJ
cord-285091-2i2v5ecg	235	4	cysteine	cysteine	NN
cord-285091-2i2v5ecg	235	5	proteases	protease	NNS
cord-285091-2i2v5ecg	235	6	in	in	IN
cord-285091-2i2v5ecg	235	7	MHC	MHC	NNP
cord-285091-2i2v5ecg	235	8	class	class	NN
cord-285091-2i2v5ecg	235	9	Ii	Ii	NNP
cord-285091-2i2v5ecg	235	10	antigen	antigen	NN
cord-285091-2i2v5ecg	235	11	presentation	presentation	NN
cord-285091-2i2v5ecg	235	12	Endolysosomal	Endolysosomal	NNP
cord-285091-2i2v5ecg	235	13	proteases	protease	NNS
cord-285091-2i2v5ecg	235	14	and	and	CC
cord-285091-2i2v5ecg	235	15	their	-PRON-	PRP$
cord-285091-2i2v5ecg	235	16	inhibitors	inhibitor	NNS
cord-285091-2i2v5ecg	235	17	in	in	IN
cord-285091-2i2v5ecg	235	18	immunity	immunity	NN
cord-285091-2i2v5ecg	235	19	Serpin	Serpin	NNP
cord-285091-2i2v5ecg	235	20	2a	2a	CD
cord-285091-2i2v5ecg	235	21	is	be	VBZ
cord-285091-2i2v5ecg	235	22	induced	induce	VBN
cord-285091-2i2v5ecg	235	23	in	in	IN
cord-285091-2i2v5ecg	235	24	activated	activate	VBN
cord-285091-2i2v5ecg	235	25	macrophages	macrophage	NNS
cord-285091-2i2v5ecg	235	26	and	and	CC
cord-285091-2i2v5ecg	235	27	conjugates	conjugate	NNS
cord-285091-2i2v5ecg	235	28	to	to	IN
cord-285091-2i2v5ecg	235	29	a	a	DT
cord-285091-2i2v5ecg	235	30	ubiquitin	ubiquitin	JJ
cord-285091-2i2v5ecg	235	31	homolog	homolog	NN
cord-285091-2i2v5ecg	235	32	Differential	differential	JJ
cord-285091-2i2v5ecg	235	33	regulation	regulation	NN
cord-285091-2i2v5ecg	235	34	of	of	IN
cord-285091-2i2v5ecg	235	35	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	235	36	S	s	NN
cord-285091-2i2v5ecg	235	37	and	and	CC
cord-285091-2i2v5ecg	235	38	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	235	39	L	l	NN
cord-285091-2i2v5ecg	235	40	in	in	IN
cord-285091-2i2v5ecg	235	41	interferon	interferon	NN
cord-285091-2i2v5ecg	235	42	-treated	-treate	VBD
cord-285091-2i2v5ecg	235	43	macrophages	macrophage	NNS
cord-285091-2i2v5ecg	235	44	Internalization	internalization	NN
cord-285091-2i2v5ecg	235	45	of	of	IN
cord-285091-2i2v5ecg	235	46	exogenous	exogenous	JJ
cord-285091-2i2v5ecg	235	47	cystatin	cystatin	NN
cord-285091-2i2v5ecg	235	48	F	F	NNP
cord-285091-2i2v5ecg	235	49	supresses	supresse	VBZ
cord-285091-2i2v5ecg	235	50	cysteine	cysteine	NN
cord-285091-2i2v5ecg	235	51	proteases	protease	NNS
cord-285091-2i2v5ecg	235	52	and	and	CC
cord-285091-2i2v5ecg	235	53	induces	induce	VBZ
cord-285091-2i2v5ecg	235	54	the	the	DT
cord-285091-2i2v5ecg	235	55	accumulation	accumulation	NN
cord-285091-2i2v5ecg	235	56	of	of	IN
cord-285091-2i2v5ecg	235	57	single	single	JJ
cord-285091-2i2v5ecg	235	58	-	-	HYPH
cord-285091-2i2v5ecg	235	59	chain	chain	NN
cord-285091-2i2v5ecg	235	60	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	235	61	L	l	NN
cord-285091-2i2v5ecg	235	62	by	by	IN
cord-285091-2i2v5ecg	235	63	multiple	multiple	JJ
cord-285091-2i2v5ecg	235	64	mechanisms	mechanism	NNS
cord-285091-2i2v5ecg	235	65	Increased	increase	VBN
cord-285091-2i2v5ecg	235	66	nucleolar	nucleolar	JJ
cord-285091-2i2v5ecg	235	67	localization	localization	NN
cord-285091-2i2v5ecg	235	68	of	of	IN
cord-285091-2i2v5ecg	235	69	Spia3	Spia3	NNP
cord-285091-2i2v5ecg	235	70	g	g	NNP
cord-285091-2i2v5ecg	235	71	in	in	RP
cord-285091-2i2v5ecg	235	72	classically	classically	RB
cord-285091-2i2v5ecg	235	73	but	but	CC
cord-285091-2i2v5ecg	235	74	not	not	RB
cord-285091-2i2v5ecg	235	75	alternatively	alternatively	RB
cord-285091-2i2v5ecg	235	76	activated	activate	VBN
cord-285091-2i2v5ecg	235	77	macrophages	macrophage	NNS
cord-285091-2i2v5ecg	235	78	The	the	DT
cord-285091-2i2v5ecg	235	79	inflammasomes	inflammasome	NNS
cord-285091-2i2v5ecg	235	80	Control	Control	NNP
cord-285091-2i2v5ecg	235	81	of	of	IN
cord-285091-2i2v5ecg	235	82	antiviral	antiviral	JJ
cord-285091-2i2v5ecg	235	83	immunity	immunity	NN
cord-285091-2i2v5ecg	235	84	by	by	IN
cord-285091-2i2v5ecg	235	85	pattern	pattern	NN
cord-285091-2i2v5ecg	235	86	recognition	recognition	NN
cord-285091-2i2v5ecg	235	87	and	and	CC
cord-285091-2i2v5ecg	235	88	the	the	DT
cord-285091-2i2v5ecg	235	89	microbiome	microbiome	NN
cord-285091-2i2v5ecg	236	1	The	the	DT
cord-285091-2i2v5ecg	236	2	NALP3	NALP3	NNP
cord-285091-2i2v5ecg	236	3	inflammasome	inflammasome	NNP
cord-285091-2i2v5ecg	236	4	is	be	VBZ
cord-285091-2i2v5ecg	236	5	involved	involve	VBN
cord-285091-2i2v5ecg	236	6	in	in	IN
cord-285091-2i2v5ecg	236	7	the	the	DT
cord-285091-2i2v5ecg	236	8	innate	innate	JJ
cord-285091-2i2v5ecg	236	9	immune	immune	JJ
cord-285091-2i2v5ecg	236	10	response	response	NN
cord-285091-2i2v5ecg	236	11	to	to	IN
cord-285091-2i2v5ecg	236	12	amyloid	amyloid	NN
cord-285091-2i2v5ecg	236	13	-	-	HYPH
cord-285091-2i2v5ecg	236	14	beta	beta	NN
cord-285091-2i2v5ecg	236	15	Silica	Silica	NNP
cord-285091-2i2v5ecg	236	16	crystals	crystal	NNS
cord-285091-2i2v5ecg	236	17	and	and	CC
cord-285091-2i2v5ecg	236	18	aluminum	aluminum	NN
cord-285091-2i2v5ecg	236	19	salts	salt	NNS
cord-285091-2i2v5ecg	236	20	activate	activate	VBP
cord-285091-2i2v5ecg	236	21	the	the	DT
cord-285091-2i2v5ecg	236	22	NALP3	NALP3	NNP
cord-285091-2i2v5ecg	236	23	inflammasome	inflammasome	NNP
cord-285091-2i2v5ecg	236	24	through	through	IN
cord-285091-2i2v5ecg	236	25	phagosomal	phagosomal	NNP
cord-285091-2i2v5ecg	236	26	destabilization	destabilization	NN
cord-285091-2i2v5ecg	237	1	Uric	uric	JJ
cord-285091-2i2v5ecg	237	2	acid	acid	NN
cord-285091-2i2v5ecg	237	3	promotes	promote	VBZ
cord-285091-2i2v5ecg	237	4	an	an	DT
cord-285091-2i2v5ecg	237	5	acute	acute	JJ
cord-285091-2i2v5ecg	237	6	inflammatory	inflammatory	JJ
cord-285091-2i2v5ecg	237	7	response	response	NN
cord-285091-2i2v5ecg	237	8	to	to	IN
cord-285091-2i2v5ecg	237	9	sterile	sterile	JJ
cord-285091-2i2v5ecg	237	10	cell	cell	NN
cord-285091-2i2v5ecg	237	11	death	death	NN
cord-285091-2i2v5ecg	237	12	in	in	IN
cord-285091-2i2v5ecg	237	13	mice	mouse	NNS
cord-285091-2i2v5ecg	238	1	Disease	Disease	NNP
cord-285091-2i2v5ecg	238	2	-	-	HYPH
cord-285091-2i2v5ecg	238	3	associated	associate	VBN
cord-285091-2i2v5ecg	238	4	amyloid	amyloid	NN
cord-285091-2i2v5ecg	238	5	and	and	CC
cord-285091-2i2v5ecg	238	6	misfolded	misfolde	VBD
cord-285091-2i2v5ecg	238	7	protein	protein	NN
cord-285091-2i2v5ecg	238	8	aggregates	aggregate	NNS
cord-285091-2i2v5ecg	238	9	activate	activate	VBP
cord-285091-2i2v5ecg	238	10	the	the	DT
cord-285091-2i2v5ecg	238	11	inflammasome	inflammasome	NN
cord-285091-2i2v5ecg	239	1	Nlrp3	Nlrp3	NNP
cord-285091-2i2v5ecg	240	1	inflammasomes	inflammasome	NNS
cord-285091-2i2v5ecg	240	2	are	be	VBP
cord-285091-2i2v5ecg	240	3	required	require	VBN
cord-285091-2i2v5ecg	240	4	for	for	IN
cord-285091-2i2v5ecg	240	5	atherogenesis	atherogenesis	NN
cord-285091-2i2v5ecg	240	6	and	and	CC
cord-285091-2i2v5ecg	240	7	activated	activate	VBN
cord-285091-2i2v5ecg	240	8	by	by	IN
cord-285091-2i2v5ecg	240	9	cholesterol	cholesterol	NN
cord-285091-2i2v5ecg	240	10	crystals	crystal	NNS
cord-285091-2i2v5ecg	240	11	Activation	Activation	NNP
cord-285091-2i2v5ecg	240	12	of	of	IN
cord-285091-2i2v5ecg	240	13	an	an	DT
cord-285091-2i2v5ecg	240	14	NLRP3	nlrp3	XX
cord-285091-2i2v5ecg	240	15	inflammasome	inflammasome	NN
cord-285091-2i2v5ecg	240	16	restricts	restrict	VBZ
cord-285091-2i2v5ecg	240	17	Mycobacterium	Mycobacterium	NNP
cord-285091-2i2v5ecg	240	18	kansasii	kansasii	VBZ
cord-285091-2i2v5ecg	240	19	infection	infection	NN
cord-285091-2i2v5ecg	240	20	Origin	origin	NN
cord-285091-2i2v5ecg	240	21	and	and	CC
cord-285091-2i2v5ecg	240	22	development	development	NN
cord-285091-2i2v5ecg	240	23	of	of	IN
cord-285091-2i2v5ecg	240	24	dendritic	dendritic	JJ
cord-285091-2i2v5ecg	240	25	cells	cell	NNS
cord-285091-2i2v5ecg	240	26	Development	Development	NNP
cord-285091-2i2v5ecg	240	27	of	of	IN
cord-285091-2i2v5ecg	240	28	plasmacytoid	plasmacytoid	NNP
cord-285091-2i2v5ecg	240	29	and	and	CC
cord-285091-2i2v5ecg	240	30	conventional	conventional	JJ
cord-285091-2i2v5ecg	240	31	dendritic	dendritic	JJ
cord-285091-2i2v5ecg	240	32	cell	cell	NN
cord-285091-2i2v5ecg	240	33	subtypes	subtype	NNS
cord-285091-2i2v5ecg	240	34	from	from	IN
cord-285091-2i2v5ecg	240	35	single	single	JJ
cord-285091-2i2v5ecg	240	36	precursor	precursor	NN
cord-285091-2i2v5ecg	240	37	cells	cell	NNS
cord-285091-2i2v5ecg	240	38	derived	derive	VBN
cord-285091-2i2v5ecg	240	39	in	in	IN
cord-285091-2i2v5ecg	240	40	vitro	vitro	FW
cord-285091-2i2v5ecg	240	41	and	and	CC
cord-285091-2i2v5ecg	240	42	in	in	IN
cord-285091-2i2v5ecg	240	43	vivo	vivo	NN
cord-285091-2i2v5ecg	240	44	Consequences	consequence	NNS
cord-285091-2i2v5ecg	240	45	of	of	IN
cord-285091-2i2v5ecg	240	46	cell	cell	NN
cord-285091-2i2v5ecg	240	47	death	death	NN
cord-285091-2i2v5ecg	240	48	Cpg	Cpg	NNP
cord-285091-2i2v5ecg	240	49	DNA	DNA	NNP
cord-285091-2i2v5ecg	240	50	:	:	:
cord-285091-2i2v5ecg	241	1	A	a	DT
cord-285091-2i2v5ecg	241	2	potent	potent	JJ
cord-285091-2i2v5ecg	241	3	signal	signal	NN
cord-285091-2i2v5ecg	241	4	for	for	IN
cord-285091-2i2v5ecg	241	5	growth	growth	NN
cord-285091-2i2v5ecg	241	6	,	,	,
cord-285091-2i2v5ecg	241	7	activation	activation	NN
cord-285091-2i2v5ecg	241	8	,	,	,
cord-285091-2i2v5ecg	241	9	and	and	CC
cord-285091-2i2v5ecg	241	10	maturation	maturation	NN
cord-285091-2i2v5ecg	241	11	of	of	IN
cord-285091-2i2v5ecg	241	12	human	human	JJ
cord-285091-2i2v5ecg	241	13	dendritic	dendritic	JJ
cord-285091-2i2v5ecg	241	14	cells	cell	NNS
cord-285091-2i2v5ecg	241	15	Inflammatory	inflammatory	JJ
cord-285091-2i2v5ecg	241	16	signals	signal	NNS
cord-285091-2i2v5ecg	241	17	in	in	IN
cord-285091-2i2v5ecg	241	18	dendritic	dendritic	JJ
cord-285091-2i2v5ecg	241	19	cell	cell	NN
cord-285091-2i2v5ecg	241	20	activation	activation	NN
cord-285091-2i2v5ecg	241	21	and	and	CC
cord-285091-2i2v5ecg	241	22	the	the	DT
cord-285091-2i2v5ecg	241	23	induction	induction	NN
cord-285091-2i2v5ecg	241	24	of	of	IN
cord-285091-2i2v5ecg	241	25	adaptive	adaptive	JJ
cord-285091-2i2v5ecg	241	26	immunity	immunity	NN
cord-285091-2i2v5ecg	242	1	Inflammatory	inflammatory	JJ
cord-285091-2i2v5ecg	242	2	stimuli	stimulus	NNS
cord-285091-2i2v5ecg	242	3	induce	induce	VBP
cord-285091-2i2v5ecg	242	4	accumulation	accumulation	NN
cord-285091-2i2v5ecg	242	5	of	of	IN
cord-285091-2i2v5ecg	242	6	MHC	MHC	NNP
cord-285091-2i2v5ecg	242	7	class	class	NN
cord-285091-2i2v5ecg	242	8	Ii	Ii	NNP
cord-285091-2i2v5ecg	242	9	complexes	complex	NNS
cord-285091-2i2v5ecg	242	10	on	on	IN
cord-285091-2i2v5ecg	242	11	dendritic	dendritic	JJ
cord-285091-2i2v5ecg	242	12	cells	cell	NNS
cord-285091-2i2v5ecg	242	13	Unraveling	unravel	VBG
cord-285091-2i2v5ecg	242	14	the	the	DT
cord-285091-2i2v5ecg	242	15	functions	function	NNS
cord-285091-2i2v5ecg	242	16	of	of	IN
cord-285091-2i2v5ecg	242	17	plasmacytoid	plasmacytoid	NNP
cord-285091-2i2v5ecg	242	18	dendritic	dendritic	JJ
cord-285091-2i2v5ecg	242	19	cells	cell	NNS
cord-285091-2i2v5ecg	242	20	during	during	IN
cord-285091-2i2v5ecg	242	21	viral	viral	JJ
cord-285091-2i2v5ecg	242	22	infections	infection	NNS
cord-285091-2i2v5ecg	242	23	,	,	,
cord-285091-2i2v5ecg	242	24	autoimmunity	autoimmunity	NN
cord-285091-2i2v5ecg	242	25	,	,	,
cord-285091-2i2v5ecg	242	26	and	and	CC
cord-285091-2i2v5ecg	242	27	tolerance	tolerance	NN
cord-285091-2i2v5ecg	242	28	Differential	differential	JJ
cord-285091-2i2v5ecg	242	29	lysosomal	lysosomal	JJ
cord-285091-2i2v5ecg	242	30	proteolysis	proteolysis	NN
cord-285091-2i2v5ecg	242	31	in	in	IN
cord-285091-2i2v5ecg	242	32	antigen	antigen	NN
cord-285091-2i2v5ecg	242	33	-	-	HYPH
cord-285091-2i2v5ecg	242	34	presenting	present	VBG
cord-285091-2i2v5ecg	242	35	cells	cell	NNS
cord-285091-2i2v5ecg	242	36	determines	determine	VBZ
cord-285091-2i2v5ecg	242	37	antigen	antigen	NN
cord-285091-2i2v5ecg	242	38	fate	fate	NN
cord-285091-2i2v5ecg	242	39	Monocyte	Monocyte	NNP
cord-285091-2i2v5ecg	242	40	-	-	HYPH
cord-285091-2i2v5ecg	242	41	derived	derive	VBN
cord-285091-2i2v5ecg	242	42	dendritic	dendritic	JJ
cord-285091-2i2v5ecg	242	43	cells	cell	NNS
cord-285091-2i2v5ecg	242	44	exhibit	exhibit	VBP
cord-285091-2i2v5ecg	242	45	increased	increase	VBN
cord-285091-2i2v5ecg	242	46	levels	level	NNS
cord-285091-2i2v5ecg	242	47	of	of	IN
cord-285091-2i2v5ecg	242	48	lysosomal	lysosomal	JJ
cord-285091-2i2v5ecg	242	49	proteolysis	proteolysis	NN
cord-285091-2i2v5ecg	242	50	as	as	IN
cord-285091-2i2v5ecg	242	51	compared	compare	VBN
cord-285091-2i2v5ecg	242	52	to	to	IN
cord-285091-2i2v5ecg	242	53	other	other	JJ
cord-285091-2i2v5ecg	242	54	human	human	JJ
cord-285091-2i2v5ecg	242	55	dendritic	dendritic	JJ
cord-285091-2i2v5ecg	242	56	cell	cell	NN
cord-285091-2i2v5ecg	242	57	populations	population	NNS
cord-285091-2i2v5ecg	242	58	Cathepsin	Cathepsin	NNP
cord-285091-2i2v5ecg	242	59	S	S	NNP
cord-285091-2i2v5ecg	242	60	required	require	VBD
cord-285091-2i2v5ecg	242	61	for	for	IN
cord-285091-2i2v5ecg	242	62	normal	normal	JJ
cord-285091-2i2v5ecg	242	63	MHC	MHC	NNP
cord-285091-2i2v5ecg	242	64	class	class	NN
cord-285091-2i2v5ecg	242	65	Ii	Ii	NNP
cord-285091-2i2v5ecg	242	66	peptide	peptide	NN
cord-285091-2i2v5ecg	242	67	loading	loading	NN
cord-285091-2i2v5ecg	242	68	and	and	CC
cord-285091-2i2v5ecg	242	69	germinal	germinal	JJ
cord-285091-2i2v5ecg	242	70	center	center	NN
cord-285091-2i2v5ecg	242	71	development	development	NN
cord-285091-2i2v5ecg	242	72	Cathepsin	Cathepsin	NNP
cord-285091-2i2v5ecg	242	73	L	L	NNP
cord-285091-2i2v5ecg	242	74	:	:	:
cord-285091-2i2v5ecg	242	75	Critical	critical	JJ
cord-285091-2i2v5ecg	242	76	role	role	NN
cord-285091-2i2v5ecg	242	77	in	in	IN
cord-285091-2i2v5ecg	242	78	II	ii	CD
cord-285091-2i2v5ecg	242	79	degradation	degradation	NN
cord-285091-2i2v5ecg	242	80	and	and	CC
cord-285091-2i2v5ecg	242	81	CD4	CD4	NNP
cord-285091-2i2v5ecg	242	82	T	T	NNP
cord-285091-2i2v5ecg	242	83	cell	cell	NN
cord-285091-2i2v5ecg	242	84	selection	selection	NN
cord-285091-2i2v5ecg	242	85	in	in	IN
cord-285091-2i2v5ecg	242	86	the	the	DT
cord-285091-2i2v5ecg	242	87	thymus	thymus	NN
cord-285091-2i2v5ecg	242	88	Impaired	impair	VBN
cord-285091-2i2v5ecg	242	89	invariant	invariant	JJ
cord-285091-2i2v5ecg	242	90	chain	chain	NN
cord-285091-2i2v5ecg	242	91	degradation	degradation	NN
cord-285091-2i2v5ecg	242	92	and	and	CC
cord-285091-2i2v5ecg	242	93	antigen	antigen	NN
cord-285091-2i2v5ecg	242	94	presentation	presentation	NN
cord-285091-2i2v5ecg	242	95	and	and	CC
cord-285091-2i2v5ecg	242	96	diminished	diminish	VBD
cord-285091-2i2v5ecg	242	97	collagen	collagen	NN
cord-285091-2i2v5ecg	242	98	-	-	HYPH
cord-285091-2i2v5ecg	242	99	induced	induce	VBN
cord-285091-2i2v5ecg	242	100	arthritis	arthritis	NN
cord-285091-2i2v5ecg	242	101	in	in	IN
cord-285091-2i2v5ecg	243	1	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	243	2	S	S	NNP
cord-285091-2i2v5ecg	243	3	null	null	JJ
cord-285091-2i2v5ecg	243	4	mice	mouse	NNS
cord-285091-2i2v5ecg	244	1	Cathepsin	Cathepsin	NNP
cord-285091-2i2v5ecg	244	2	V	V	NNP
cord-285091-2i2v5ecg	244	3	is	be	VBZ
cord-285091-2i2v5ecg	244	4	involved	involve	VBN
cord-285091-2i2v5ecg	244	5	in	in	IN
cord-285091-2i2v5ecg	244	6	the	the	DT
cord-285091-2i2v5ecg	244	7	degradation	degradation	NN
cord-285091-2i2v5ecg	244	8	of	of	IN
cord-285091-2i2v5ecg	244	9	invariant	invariant	JJ
cord-285091-2i2v5ecg	244	10	chain	chain	NN
cord-285091-2i2v5ecg	244	11	in	in	IN
cord-285091-2i2v5ecg	244	12	human	human	JJ
cord-285091-2i2v5ecg	244	13	thymus	thymus	NN
cord-285091-2i2v5ecg	244	14	and	and	CC
cord-285091-2i2v5ecg	244	15	is	be	VBZ
cord-285091-2i2v5ecg	244	16	overexpressed	overexpresse	VBN
cord-285091-2i2v5ecg	244	17	in	in	IN
cord-285091-2i2v5ecg	244	18	myasthenia	myasthenia	NN
cord-285091-2i2v5ecg	245	1	gravis	gravis	NNP
cord-285091-2i2v5ecg	245	2	Developmental	Developmental	NNP
cord-285091-2i2v5ecg	245	3	regulation	regulation	NN
cord-285091-2i2v5ecg	245	4	of	of	IN
cord-285091-2i2v5ecg	245	5	invariant	invariant	JJ
cord-285091-2i2v5ecg	245	6	chain	chain	NN
cord-285091-2i2v5ecg	245	7	proteolysis	proteolysis	NN
cord-285091-2i2v5ecg	245	8	controls	control	VBZ
cord-285091-2i2v5ecg	245	9	MHC	MHC	NNP
cord-285091-2i2v5ecg	245	10	class	class	NN
cord-285091-2i2v5ecg	245	11	Ii	Ii	NNP
cord-285091-2i2v5ecg	245	12	trafficking	traffic	VBG
cord-285091-2i2v5ecg	245	13	in	in	IN
cord-285091-2i2v5ecg	245	14	mouse	mouse	NN
cord-285091-2i2v5ecg	245	15	dendritic	dendritic	JJ
cord-285091-2i2v5ecg	245	16	cells	cell	NNS
cord-285091-2i2v5ecg	246	1	The	the	DT
cord-285091-2i2v5ecg	246	2	protease	protease	NN
cord-285091-2i2v5ecg	246	3	inhibitor	inhibitor	NN
cord-285091-2i2v5ecg	246	4	cystatin	cystatin	NN
cord-285091-2i2v5ecg	246	5	C	C	NNP
cord-285091-2i2v5ecg	246	6	is	be	VBZ
cord-285091-2i2v5ecg	246	7	differentially	differentially	RB
cord-285091-2i2v5ecg	246	8	expressed	express	VBN
cord-285091-2i2v5ecg	246	9	among	among	IN
cord-285091-2i2v5ecg	246	10	dendritic	dendritic	JJ
cord-285091-2i2v5ecg	246	11	cell	cell	NN
cord-285091-2i2v5ecg	246	12	populations	population	NNS
cord-285091-2i2v5ecg	246	13	,	,	,
cord-285091-2i2v5ecg	246	14	but	but	CC
cord-285091-2i2v5ecg	246	15	does	do	VBZ
cord-285091-2i2v5ecg	246	16	not	not	RB
cord-285091-2i2v5ecg	246	17	control	control	VB
cord-285091-2i2v5ecg	246	18	antigen	antigen	NN
cord-285091-2i2v5ecg	246	19	presentation	presentation	NN
cord-285091-2i2v5ecg	246	20	Plasmacytoid	Plasmacytoid	NNP
cord-285091-2i2v5ecg	246	21	monocytes	monocyte	NNS
cord-285091-2i2v5ecg	246	22	migrate	migrate	VBP
cord-285091-2i2v5ecg	246	23	to	to	IN
cord-285091-2i2v5ecg	246	24	inflamed	inflamed	JJ
cord-285091-2i2v5ecg	246	25	lymph	lymph	NN
cord-285091-2i2v5ecg	246	26	nodes	node	NNS
cord-285091-2i2v5ecg	246	27	and	and	CC
cord-285091-2i2v5ecg	246	28	produce	produce	VB
cord-285091-2i2v5ecg	246	29	large	large	JJ
cord-285091-2i2v5ecg	246	30	amounts	amount	NNS
cord-285091-2i2v5ecg	246	31	of	of	IN
cord-285091-2i2v5ecg	246	32	type	type	NN
cord-285091-2i2v5ecg	247	1	I	-PRON-	PRP
cord-285091-2i2v5ecg	247	2	interferon	interferon	RB
cord-285091-2i2v5ecg	248	1	The	the	DT
cord-285091-2i2v5ecg	248	2	interaction	interaction	NN
cord-285091-2i2v5ecg	248	3	between	between	IN
cord-285091-2i2v5ecg	248	4	the	the	DT
cord-285091-2i2v5ecg	248	5	ER	ER	NNP
cord-285091-2i2v5ecg	248	6	membrane	membrane	NN
cord-285091-2i2v5ecg	248	7	protein	protein	NN
cord-285091-2i2v5ecg	248	8	UNC93b	UNC93b	NNS
cord-285091-2i2v5ecg	248	9	and	and	CC
cord-285091-2i2v5ecg	248	10	TLR3	TLR3	NNP
cord-285091-2i2v5ecg	248	11	,	,	,
cord-285091-2i2v5ecg	248	12	7	7	CD
cord-285091-2i2v5ecg	248	13	,	,	,
cord-285091-2i2v5ecg	248	14	and	and	CC
cord-285091-2i2v5ecg	248	15	9	9	CD
cord-285091-2i2v5ecg	248	16	is	be	VBZ
cord-285091-2i2v5ecg	248	17	crucial	crucial	JJ
cord-285091-2i2v5ecg	248	18	for	for	IN
cord-285091-2i2v5ecg	248	19	TLR	TLR	NNP
cord-285091-2i2v5ecg	248	20	signaling	signal	VBG
cord-285091-2i2v5ecg	248	21	Unc93b1	unc93b1	NN
cord-285091-2i2v5ecg	248	22	biases	bias	NNS
cord-285091-2i2v5ecg	248	23	toll	toll	NN
cord-285091-2i2v5ecg	248	24	-	-	HYPH
cord-285091-2i2v5ecg	248	25	like	like	JJ
cord-285091-2i2v5ecg	248	26	receptor	receptor	NN
cord-285091-2i2v5ecg	248	27	responses	response	NNS
cord-285091-2i2v5ecg	248	28	to	to	IN
cord-285091-2i2v5ecg	248	29	nucleic	nucleic	JJ
cord-285091-2i2v5ecg	248	30	acid	acid	NN
cord-285091-2i2v5ecg	248	31	in	in	IN
cord-285091-2i2v5ecg	248	32	dendritic	dendritic	JJ
cord-285091-2i2v5ecg	248	33	cells	cell	NNS
cord-285091-2i2v5ecg	248	34	toward	toward	IN
cord-285091-2i2v5ecg	248	35	DNA-	DNA-	NNP
cord-285091-2i2v5ecg	249	1	but	but	CC
cord-285091-2i2v5ecg	249	2	against	against	IN
cord-285091-2i2v5ecg	249	3	RNA	RNA	NNP
cord-285091-2i2v5ecg	249	4	-	-	HYPH
cord-285091-2i2v5ecg	249	5	sensing	sense	VBG
cord-285091-2i2v5ecg	249	6	Cathepsin	Cathepsin	NNP
cord-285091-2i2v5ecg	249	7	K	K	NNP
cord-285091-2i2v5ecg	249	8	-	-	HYPH
cord-285091-2i2v5ecg	249	9	dependent	dependent	JJ
cord-285091-2i2v5ecg	249	10	Toll	Toll	NNP
cord-285091-2i2v5ecg	249	11	-	-	HYPH
cord-285091-2i2v5ecg	249	12	like	like	JJ
cord-285091-2i2v5ecg	249	13	receptor	receptor	NN
cord-285091-2i2v5ecg	249	14	9	9	CD
cord-285091-2i2v5ecg	249	15	signaling	signaling	NN
cord-285091-2i2v5ecg	249	16	revealed	reveal	VBN
cord-285091-2i2v5ecg	249	17	in	in	IN
cord-285091-2i2v5ecg	249	18	experimental	experimental	JJ
cord-285091-2i2v5ecg	249	19	arthritis	arthritis	NN
cord-285091-2i2v5ecg	249	20	Nucleic	nucleic	CD
cord-285091-2i2v5ecg	249	21	acid	acid	NN
cord-285091-2i2v5ecg	249	22	recognition	recognition	NN
cord-285091-2i2v5ecg	249	23	by	by	IN
cord-285091-2i2v5ecg	249	24	Toll	toll	NN
cord-285091-2i2v5ecg	249	25	-	-	HYPH
cord-285091-2i2v5ecg	249	26	like	like	JJ
cord-285091-2i2v5ecg	249	27	receptors	receptor	NNS
cord-285091-2i2v5ecg	249	28	is	be	VBZ
cord-285091-2i2v5ecg	249	29	coupled	couple	VBN
cord-285091-2i2v5ecg	249	30	to	to	IN
cord-285091-2i2v5ecg	249	31	stepwise	stepwise	JJ
cord-285091-2i2v5ecg	249	32	processing	processing	NN
cord-285091-2i2v5ecg	249	33	by	by	IN
cord-285091-2i2v5ecg	249	34	cathepsins	cathepsin	NNS
cord-285091-2i2v5ecg	249	35	and	and	CC
cord-285091-2i2v5ecg	249	36	asparagine	asparagine	NN
cord-285091-2i2v5ecg	249	37	endopeptidase	endopeptidase	NN
cord-285091-2i2v5ecg	250	1	The	the	DT
cord-285091-2i2v5ecg	250	2	ectodomain	ectodomain	NN
cord-285091-2i2v5ecg	250	3	of	of	IN
cord-285091-2i2v5ecg	250	4	Toll	Toll	NNP
cord-285091-2i2v5ecg	250	5	-	-	HYPH
cord-285091-2i2v5ecg	250	6	like	like	JJ
cord-285091-2i2v5ecg	250	7	receptor	receptor	NN
cord-285091-2i2v5ecg	250	8	9	9	CD
cord-285091-2i2v5ecg	250	9	is	be	VBZ
cord-285091-2i2v5ecg	250	10	cleaved	cleave	VBN
cord-285091-2i2v5ecg	250	11	to	to	TO
cord-285091-2i2v5ecg	250	12	generate	generate	VB
cord-285091-2i2v5ecg	250	13	a	a	DT
cord-285091-2i2v5ecg	250	14	functional	functional	JJ
cord-285091-2i2v5ecg	250	15	receptor	receptor	NN
cord-285091-2i2v5ecg	250	16	Proteolytic	Proteolytic	NNP
cord-285091-2i2v5ecg	250	17	cleavage	cleavage	NN
cord-285091-2i2v5ecg	250	18	in	in	IN
cord-285091-2i2v5ecg	250	19	an	an	DT
cord-285091-2i2v5ecg	250	20	endolysosomal	endolysosomal	JJ
cord-285091-2i2v5ecg	250	21	compartment	compartment	NN
cord-285091-2i2v5ecg	250	22	is	be	VBZ
cord-285091-2i2v5ecg	250	23	required	require	VBN
cord-285091-2i2v5ecg	250	24	for	for	IN
cord-285091-2i2v5ecg	250	25	activation	activation	NN
cord-285091-2i2v5ecg	250	26	of	of	IN
cord-285091-2i2v5ecg	250	27	Toll	Toll	NNP
cord-285091-2i2v5ecg	250	28	-	-	HYPH
cord-285091-2i2v5ecg	250	29	like	like	JJ
cord-285091-2i2v5ecg	250	30	receptor	receptor	NN
cord-285091-2i2v5ecg	250	31	9	9	CD
cord-285091-2i2v5ecg	250	32	Degradation	degradation	NN
cord-285091-2i2v5ecg	250	33	of	of	IN
cord-285091-2i2v5ecg	250	34	fibrinogen	fibrinogen	NN
cord-285091-2i2v5ecg	250	35	and	and	CC
cord-285091-2i2v5ecg	250	36	collagen	collagen	NN
cord-285091-2i2v5ecg	250	37	by	by	IN
cord-285091-2i2v5ecg	250	38	staphopains	staphopain	NNS
cord-285091-2i2v5ecg	250	39	,	,	,
cord-285091-2i2v5ecg	250	40	cysteine	cysteine	NN
cord-285091-2i2v5ecg	250	41	proteases	protease	NNS
cord-285091-2i2v5ecg	250	42	released	release	VBN
cord-285091-2i2v5ecg	250	43	from	from	IN
cord-285091-2i2v5ecg	250	44	Staphylococcus	Staphylococcus	NNP
cord-285091-2i2v5ecg	250	45	aureus	aureus	NN
cord-285091-2i2v5ecg	250	46	Chemokine	Chemokine	NNP
cord-285091-2i2v5ecg	250	47	-	-	HYPH
cord-285091-2i2v5ecg	250	48	like	like	JJ
cord-285091-2i2v5ecg	250	49	receptor	receptor	NN
cord-285091-2i2v5ecg	250	50	1	1	CD
cord-285091-2i2v5ecg	250	51	expression	expression	NN
cord-285091-2i2v5ecg	250	52	and	and	CC
cord-285091-2i2v5ecg	250	53	chemerin	chemerin	NN
cord-285091-2i2v5ecg	250	54	-	-	HYPH
cord-285091-2i2v5ecg	250	55	directed	direct	VBN
cord-285091-2i2v5ecg	250	56	chemotaxis	chemotaxis	NN
cord-285091-2i2v5ecg	250	57	distinguish	distinguish	VBP
cord-285091-2i2v5ecg	250	58	plasmacytoid	plasmacytoid	NNP
cord-285091-2i2v5ecg	250	59	from	from	IN
cord-285091-2i2v5ecg	250	60	myeloid	myeloid	JJ
cord-285091-2i2v5ecg	250	61	dendritic	dendritic	JJ
cord-285091-2i2v5ecg	250	62	cells	cell	NNS
cord-285091-2i2v5ecg	250	63	in	in	IN
cord-285091-2i2v5ecg	250	64	human	human	JJ
cord-285091-2i2v5ecg	250	65	blood	blood	NN
cord-285091-2i2v5ecg	250	66	Chemerin	Chemerin	NNP
cord-285091-2i2v5ecg	250	67	activation	activation	NN
cord-285091-2i2v5ecg	250	68	by	by	IN
cord-285091-2i2v5ecg	250	69	serine	serine	JJ
cord-285091-2i2v5ecg	250	70	proteases	protease	NNS
cord-285091-2i2v5ecg	250	71	of	of	IN
cord-285091-2i2v5ecg	250	72	the	the	DT
cord-285091-2i2v5ecg	250	73	coagulation	coagulation	NN
cord-285091-2i2v5ecg	250	74	,	,	,
cord-285091-2i2v5ecg	250	75	fibrinolytic	fibrinolytic	NN
cord-285091-2i2v5ecg	250	76	,	,	,
cord-285091-2i2v5ecg	250	77	and	and	CC
cord-285091-2i2v5ecg	250	78	inflammatory	inflammatory	JJ
cord-285091-2i2v5ecg	250	79	cascades	cascade	NNS
cord-285091-2i2v5ecg	250	80	Regulation	regulation	NN
cord-285091-2i2v5ecg	250	81	of	of	IN
cord-285091-2i2v5ecg	250	82	chemerin	chemerin	NNP
cord-285091-2i2v5ecg	250	83	chemoattractant	chemoattractant	NN
cord-285091-2i2v5ecg	250	84	and	and	CC
cord-285091-2i2v5ecg	250	85	antibacterial	antibacterial	JJ
cord-285091-2i2v5ecg	250	86	activity	activity	NN
cord-285091-2i2v5ecg	250	87	by	by	IN
cord-285091-2i2v5ecg	250	88	human	human	JJ
cord-285091-2i2v5ecg	250	89	cysteine	cysteine	NN
cord-285091-2i2v5ecg	250	90	cathepsins	cathepsin	NNS
cord-285091-2i2v5ecg	250	91	Staphylococcus	Staphylococcus	NNP
cord-285091-2i2v5ecg	250	92	aureus	aureus	NN
cord-285091-2i2v5ecg	251	1	-derived	-derived	SYM
cord-285091-2i2v5ecg	251	2	staphopain	staphopain	NNP
cord-285091-2i2v5ecg	251	3	B	B	NNP
cord-285091-2i2v5ecg	251	4	,	,	,
cord-285091-2i2v5ecg	251	5	a	a	DT
cord-285091-2i2v5ecg	251	6	potent	potent	JJ
cord-285091-2i2v5ecg	251	7	cysteine	cysteine	NN
cord-285091-2i2v5ecg	251	8	protease	protease	NN
cord-285091-2i2v5ecg	251	9	activator	activator	NN
cord-285091-2i2v5ecg	251	10	of	of	IN
cord-285091-2i2v5ecg	251	11	plasma	plasma	NN
cord-285091-2i2v5ecg	251	12	chemerin	chemerin	NNP
cord-285091-2i2v5ecg	252	1	Phylogenomic	Phylogenomic	NNP
cord-285091-2i2v5ecg	252	2	analysis	analysis	NN
cord-285091-2i2v5ecg	252	3	of	of	IN
cord-285091-2i2v5ecg	252	4	the	the	DT
cord-285091-2i2v5ecg	252	5	cystatin	cystatin	NN
cord-285091-2i2v5ecg	252	6	superfamily	superfamily	NN
cord-285091-2i2v5ecg	252	7	in	in	IN
cord-285091-2i2v5ecg	252	8	eukaryotes	eukaryote	NNS
cord-285091-2i2v5ecg	252	9	and	and	CC
cord-285091-2i2v5ecg	252	10	prokaryotes	prokaryotes	NNPS
cord-285091-2i2v5ecg	252	11	Ides	Ides	NNPS
cord-285091-2i2v5ecg	252	12	and	and	CC
cord-285091-2i2v5ecg	252	13	speb	speb	NNP
cord-285091-2i2v5ecg	253	1	:	:	:
cord-285091-2i2v5ecg	253	2	Immunoglobulin	immunoglobulin	NN
cord-285091-2i2v5ecg	253	3	-	-	HYPH
cord-285091-2i2v5ecg	253	4	degrading	degrade	VBG
cord-285091-2i2v5ecg	253	5	cysteine	cysteine	NN
cord-285091-2i2v5ecg	253	6	proteinases	proteinase	NNS
cord-285091-2i2v5ecg	253	7	of	of	IN
cord-285091-2i2v5ecg	253	8	Streptococcus	streptococcus	NN
cord-285091-2i2v5ecg	253	9	pyogenes	pyogene	NNS
cord-285091-2i2v5ecg	253	10	Enzymatic	enzymatic	JJ
cord-285091-2i2v5ecg	253	11	characterization	characterization	NN
cord-285091-2i2v5ecg	253	12	of	of	IN
cord-285091-2i2v5ecg	253	13	the	the	DT
cord-285091-2i2v5ecg	253	14	Streptococcal	Streptococcal	NNP
cord-285091-2i2v5ecg	253	15	endopeptidase	endopeptidase	NN
cord-285091-2i2v5ecg	253	16	,	,	,
cord-285091-2i2v5ecg	253	17	ides	ide	NNS
cord-285091-2i2v5ecg	253	18	,	,	,
cord-285091-2i2v5ecg	253	19	reveals	reveal	VBZ
cord-285091-2i2v5ecg	253	20	that	that	IN
cord-285091-2i2v5ecg	253	21	it	-PRON-	PRP
cord-285091-2i2v5ecg	253	22	is	be	VBZ
cord-285091-2i2v5ecg	253	23	a	a	DT
cord-285091-2i2v5ecg	253	24	cysteine	cysteine	NN
cord-285091-2i2v5ecg	253	25	protease	protease	NN
cord-285091-2i2v5ecg	253	26	with	with	IN
cord-285091-2i2v5ecg	253	27	strict	strict	JJ
cord-285091-2i2v5ecg	253	28	specificity	specificity	NN
cord-285091-2i2v5ecg	253	29	for	for	IN
cord-285091-2i2v5ecg	253	30	igg	igg	NN
cord-285091-2i2v5ecg	253	31	cleavage	cleavage	NN
cord-285091-2i2v5ecg	253	32	due	due	IN
cord-285091-2i2v5ecg	253	33	to	to	IN
cord-285091-2i2v5ecg	253	34	exosite	exosite	NNP
cord-285091-2i2v5ecg	253	35	binding	binding	NNP
cord-285091-2i2v5ecg	253	36	†	†	NN
cord-285091-2i2v5ecg	254	1	The	the	DT
cord-285091-2i2v5ecg	254	2	human	human	JJ
cord-285091-2i2v5ecg	254	3	protease	protease	NN
cord-285091-2i2v5ecg	254	4	inhibitor	inhibitor	NN
cord-285091-2i2v5ecg	254	5	cystatin	cystatin	NNP
cord-285091-2i2v5ecg	254	6	C	C	NNP
cord-285091-2i2v5ecg	254	7	is	be	VBZ
cord-285091-2i2v5ecg	254	8	an	an	DT
cord-285091-2i2v5ecg	254	9	activating	activate	VBG
cord-285091-2i2v5ecg	254	10	cofactor	cofactor	NN
cord-285091-2i2v5ecg	254	11	for	for	IN
cord-285091-2i2v5ecg	254	12	the	the	DT
cord-285091-2i2v5ecg	254	13	Streptococcal	Streptococcal	NNP
cord-285091-2i2v5ecg	254	14	cysteine	cysteine	NN
cord-285091-2i2v5ecg	254	15	protease	protease	NN
cord-285091-2i2v5ecg	254	16	ides	ides	NNP
cord-285091-2i2v5ecg	254	17	Anaplasma	Anaplasma	NNP
cord-285091-2i2v5ecg	255	1	phagocytophilum	phagocytophilum	NNP
cord-285091-2i2v5ecg	255	2	increases	increase	VBZ
cord-285091-2i2v5ecg	255	3	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	255	4	L	l	NN
cord-285091-2i2v5ecg	255	5	activity	activity	NN
cord-285091-2i2v5ecg	255	6	,	,	,
cord-285091-2i2v5ecg	255	7	thereby	thereby	RB
cord-285091-2i2v5ecg	255	8	globally	globally	RB
cord-285091-2i2v5ecg	255	9	influencing	influence	VBG
cord-285091-2i2v5ecg	255	10	neutrophil	neutrophil	NN
cord-285091-2i2v5ecg	255	11	function	function	NN
cord-285091-2i2v5ecg	256	1	The	the	DT
cord-285091-2i2v5ecg	256	2	cell	cell	NN
cord-285091-2i2v5ecg	256	3	biology	biology	NN
cord-285091-2i2v5ecg	256	4	of	of	IN
cord-285091-2i2v5ecg	256	5	receptor	receptor	NN
cord-285091-2i2v5ecg	256	6	-	-	HYPH
cord-285091-2i2v5ecg	256	7	mediated	mediate	VBN
cord-285091-2i2v5ecg	256	8	virus	virus	NN
cord-285091-2i2v5ecg	256	9	entry	entry	NN
cord-285091-2i2v5ecg	256	10	Changes	change	NNS
cord-285091-2i2v5ecg	256	11	in	in	IN
cord-285091-2i2v5ecg	256	12	the	the	DT
cord-285091-2i2v5ecg	256	13	conformation	conformation	NN
cord-285091-2i2v5ecg	256	14	of	of	IN
cord-285091-2i2v5ecg	256	15	influenza	influenza	NN
cord-285091-2i2v5ecg	256	16	virus	virus	NN
cord-285091-2i2v5ecg	256	17	hemagglutinin	hemagglutinin	NN
cord-285091-2i2v5ecg	256	18	at	at	IN
cord-285091-2i2v5ecg	256	19	the	the	DT
cord-285091-2i2v5ecg	256	20	pH	pH	NNP
cord-285091-2i2v5ecg	256	21	optimum	optimum	NN
cord-285091-2i2v5ecg	256	22	of	of	IN
cord-285091-2i2v5ecg	256	23	virus	virus	NN
cord-285091-2i2v5ecg	256	24	-	-	HYPH
cord-285091-2i2v5ecg	256	25	mediated	mediate	VBN
cord-285091-2i2v5ecg	256	26	membrane	membrane	NN
cord-285091-2i2v5ecg	256	27	fusion	fusion	NN
cord-285091-2i2v5ecg	256	28	Structure	Structure	NNP
cord-285091-2i2v5ecg	256	29	of	of	IN
cord-285091-2i2v5ecg	256	30	the	the	DT
cord-285091-2i2v5ecg	256	31	haemagglutinin	haemagglutinin	NNP
cord-285091-2i2v5ecg	256	32	membrane	membrane	NN
cord-285091-2i2v5ecg	256	33	glycoprotein	glycoprotein	NN
cord-285091-2i2v5ecg	256	34	of	of	IN
cord-285091-2i2v5ecg	256	35	influenza	influenza	NN
cord-285091-2i2v5ecg	256	36	virus	virus	NN
cord-285091-2i2v5ecg	256	37	at	at	IN
cord-285091-2i2v5ecg	256	38	3	3	CD
cord-285091-2i2v5ecg	256	39	A	a	DT
cord-285091-2i2v5ecg	256	40	resolution	resolution	NN
cord-285091-2i2v5ecg	256	41	Structural	structural	JJ
cord-285091-2i2v5ecg	256	42	basis	basis	NN
cord-285091-2i2v5ecg	256	43	for	for	IN
cord-285091-2i2v5ecg	256	44	paramyxovirus	paramyxovirus	NN
cord-285091-2i2v5ecg	256	45	-	-	HYPH
cord-285091-2i2v5ecg	256	46	mediated	mediate	VBN
cord-285091-2i2v5ecg	256	47	membrane	membrane	NN
cord-285091-2i2v5ecg	256	48	fusion	fusion	NN
cord-285091-2i2v5ecg	256	49	Core	Core	NNP
cord-285091-2i2v5ecg	256	50	structure	structure	NN
cord-285091-2i2v5ecg	256	51	of	of	IN
cord-285091-2i2v5ecg	256	52	gp41	gp41	NNP
cord-285091-2i2v5ecg	256	53	from	from	IN
cord-285091-2i2v5ecg	256	54	the	the	DT
cord-285091-2i2v5ecg	256	55	hiv	hiv	NNP
cord-285091-2i2v5ecg	256	56	envelope	envelope	NNP
cord-285091-2i2v5ecg	256	57	glycoprotein	glycoprotein	NNP
cord-285091-2i2v5ecg	256	58	Atomic	atomic	JJ
cord-285091-2i2v5ecg	256	59	structure	structure	NN
cord-285091-2i2v5ecg	256	60	of	of	IN
cord-285091-2i2v5ecg	256	61	the	the	DT
cord-285091-2i2v5ecg	256	62	ectodomain	ectodomain	NN
cord-285091-2i2v5ecg	256	63	from	from	IN
cord-285091-2i2v5ecg	256	64	HIV-1	HIV-1	NNP
cord-285091-2i2v5ecg	256	65	gp41	gp41	NNP
cord-285091-2i2v5ecg	256	66	Endosomal	Endosomal	NNP
cord-285091-2i2v5ecg	256	67	proteolysis	proteolysis	NN
cord-285091-2i2v5ecg	256	68	of	of	IN
cord-285091-2i2v5ecg	256	69	the	the	DT
cord-285091-2i2v5ecg	256	70	Ebola	Ebola	NNP
cord-285091-2i2v5ecg	256	71	virus	virus	NN
cord-285091-2i2v5ecg	256	72	glycoprotein	glycoprotein	NN
cord-285091-2i2v5ecg	256	73	is	be	VBZ
cord-285091-2i2v5ecg	256	74	necessary	necessary	JJ
cord-285091-2i2v5ecg	256	75	for	for	IN
cord-285091-2i2v5ecg	256	76	infection	infection	NN
cord-285091-2i2v5ecg	256	77	Ebola	Ebola	NNP
cord-285091-2i2v5ecg	256	78	and	and	CC
cord-285091-2i2v5ecg	256	79	Marburg	Marburg	NNP
cord-285091-2i2v5ecg	256	80	hemorrhagic	hemorrhagic	JJ
cord-285091-2i2v5ecg	256	81	fevers	fever	NNS
cord-285091-2i2v5ecg	256	82	:	:	:
cord-285091-2i2v5ecg	256	83	Neglected	neglect	VBN
cord-285091-2i2v5ecg	256	84	tropical	tropical	JJ
cord-285091-2i2v5ecg	256	85	diseases	disease	NNS
cord-285091-2i2v5ecg	256	86	?	?	.
cord-285091-2i2v5ecg	257	1	Structure	structure	NN
cord-285091-2i2v5ecg	257	2	of	of	IN
cord-285091-2i2v5ecg	257	3	the	the	DT
cord-285091-2i2v5ecg	257	4	Ebola	Ebola	NNP
cord-285091-2i2v5ecg	257	5	virus	virus	NN
cord-285091-2i2v5ecg	257	6	glycoprotein	glycoprotein	NN
cord-285091-2i2v5ecg	257	7	bound	bind	VBN
cord-285091-2i2v5ecg	257	8	to	to	IN
cord-285091-2i2v5ecg	257	9	an	an	DT
cord-285091-2i2v5ecg	257	10	antibody	antibody	NN
cord-285091-2i2v5ecg	257	11	from	from	IN
cord-285091-2i2v5ecg	257	12	a	a	DT
cord-285091-2i2v5ecg	257	13	human	human	JJ
cord-285091-2i2v5ecg	257	14	survivor	survivor	NN
cord-285091-2i2v5ecg	257	15	Ebolavirus	Ebolavirus	NNP
cord-285091-2i2v5ecg	257	16	glycoprotein	glycoprotein	NN
cord-285091-2i2v5ecg	257	17	structure	structure	NN
cord-285091-2i2v5ecg	257	18	and	and	CC
cord-285091-2i2v5ecg	257	19	mechanism	mechanism	NN
cord-285091-2i2v5ecg	257	20	of	of	IN
cord-285091-2i2v5ecg	257	21	entry	entry	NN
cord-285091-2i2v5ecg	257	22	Biochemical	biochemical	JJ
cord-285091-2i2v5ecg	257	23	and	and	CC
cord-285091-2i2v5ecg	257	24	structural	structural	JJ
cord-285091-2i2v5ecg	257	25	characterization	characterization	NN
cord-285091-2i2v5ecg	257	26	of	of	IN
cord-285091-2i2v5ecg	257	27	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	257	28	L	l	NN
cord-285091-2i2v5ecg	257	29	-	-	HYPH
cord-285091-2i2v5ecg	257	30	processed	process	VBN
cord-285091-2i2v5ecg	257	31	Ebola	Ebola	NNP
cord-285091-2i2v5ecg	257	32	virus	virus	NN
cord-285091-2i2v5ecg	257	33	glycoprotein	glycoprotein	NN
cord-285091-2i2v5ecg	257	34	:	:	:
cord-285091-2i2v5ecg	258	1	Implications	implication	NNS
cord-285091-2i2v5ecg	258	2	for	for	IN
cord-285091-2i2v5ecg	258	3	viral	viral	JJ
cord-285091-2i2v5ecg	258	4	entry	entry	NN
cord-285091-2i2v5ecg	258	5	and	and	CC
cord-285091-2i2v5ecg	258	6	immunogenicity	immunogenicity	JJ
cord-285091-2i2v5ecg	258	7	Role	role	NN
cord-285091-2i2v5ecg	258	8	of	of	IN
cord-285091-2i2v5ecg	258	9	endosomal	endosomal	NNP
cord-285091-2i2v5ecg	258	10	cathepsins	cathepsin	NNS
cord-285091-2i2v5ecg	258	11	in	in	IN
cord-285091-2i2v5ecg	258	12	entry	entry	NN
cord-285091-2i2v5ecg	258	13	mediated	mediate	VBN
cord-285091-2i2v5ecg	258	14	by	by	IN
cord-285091-2i2v5ecg	258	15	the	the	DT
cord-285091-2i2v5ecg	258	16	ebola	ebola	NNP
cord-285091-2i2v5ecg	258	17	virus	virus	NN
cord-285091-2i2v5ecg	258	18	glycoprotein	glycoprotein	VBG
cord-285091-2i2v5ecg	258	19	A	a	DT
cord-285091-2i2v5ecg	258	20	forward	forward	JJ
cord-285091-2i2v5ecg	258	21	genetic	genetic	JJ
cord-285091-2i2v5ecg	258	22	strategy	strategy	NN
cord-285091-2i2v5ecg	258	23	reveals	reveal	VBZ
cord-285091-2i2v5ecg	258	24	destabilizing	destabilize	VBG
cord-285091-2i2v5ecg	258	25	mutations	mutation	NNS
cord-285091-2i2v5ecg	258	26	in	in	IN
cord-285091-2i2v5ecg	258	27	the	the	DT
cord-285091-2i2v5ecg	258	28	Ebola	Ebola	NNP
cord-285091-2i2v5ecg	258	29	virus	virus	NN
cord-285091-2i2v5ecg	258	30	glycoprotein	glycoprotein	NN
cord-285091-2i2v5ecg	258	31	that	that	WDT
cord-285091-2i2v5ecg	258	32	alter	alter	VBP
cord-285091-2i2v5ecg	258	33	its	-PRON-	PRP$
cord-285091-2i2v5ecg	258	34	protease	protease	NN
cord-285091-2i2v5ecg	258	35	dependence	dependence	NN
cord-285091-2i2v5ecg	258	36	during	during	IN
cord-285091-2i2v5ecg	258	37	cell	cell	NN
cord-285091-2i2v5ecg	258	38	entry	entry	NN
cord-285091-2i2v5ecg	259	1	Small	small	JJ
cord-285091-2i2v5ecg	259	2	molecule	molecule	NN
cord-285091-2i2v5ecg	259	3	inhibitors	inhibitor	NNS
cord-285091-2i2v5ecg	259	4	reveal	reveal	VBP
cord-285091-2i2v5ecg	259	5	Niemann	Niemann	NNP
cord-285091-2i2v5ecg	259	6	-	-	HYPH
cord-285091-2i2v5ecg	259	7	Pick	Pick	NNP
cord-285091-2i2v5ecg	259	8	C1	C1	NNP
cord-285091-2i2v5ecg	259	9	is	be	VBZ
cord-285091-2i2v5ecg	259	10	essential	essential	JJ
cord-285091-2i2v5ecg	259	11	for	for	IN
cord-285091-2i2v5ecg	259	12	ebola	ebola	NNP
cord-285091-2i2v5ecg	259	13	virus	virus	NN
cord-285091-2i2v5ecg	259	14	infection	infection	NN
cord-285091-2i2v5ecg	259	15	Ebola	Ebola	NNP
cord-285091-2i2v5ecg	259	16	virus	virus	NN
cord-285091-2i2v5ecg	259	17	entry	entry	NN
cord-285091-2i2v5ecg	259	18	requires	require	VBZ
cord-285091-2i2v5ecg	260	1	the	the	DT
cord-285091-2i2v5ecg	260	2	cholesterol	cholesterol	NN
cord-285091-2i2v5ecg	260	3	transporter	transporter	NN
cord-285091-2i2v5ecg	260	4	Niemann	Niemann	NNP
cord-285091-2i2v5ecg	260	5	-	-	HYPH
cord-285091-2i2v5ecg	260	6	Pick	Pick	NNP
cord-285091-2i2v5ecg	260	7	C1	C1	NNP
cord-285091-2i2v5ecg	260	8	Filoviruses	Filoviruses	NNPS
cord-285091-2i2v5ecg	260	9	require	require	VBP
cord-285091-2i2v5ecg	260	10	endosomal	endosomal	NNP
cord-285091-2i2v5ecg	260	11	cysteine	cysteine	NN
cord-285091-2i2v5ecg	260	12	proteases	protease	NNS
cord-285091-2i2v5ecg	260	13	for	for	IN
cord-285091-2i2v5ecg	260	14	entry	entry	NN
cord-285091-2i2v5ecg	260	15	but	but	CC
cord-285091-2i2v5ecg	260	16	exhibit	exhibit	VB
cord-285091-2i2v5ecg	260	17	distinct	distinct	JJ
cord-285091-2i2v5ecg	260	18	protease	protease	NN
cord-285091-2i2v5ecg	260	19	preferences	preference	NNS
cord-285091-2i2v5ecg	260	20	Ebola	Ebola	NNP
cord-285091-2i2v5ecg	260	21	haemorrhagic	haemorrhagic	JJ
cord-285091-2i2v5ecg	260	22	fever	fever	NN
cord-285091-2i2v5ecg	261	1	Successful	successful	JJ
cord-285091-2i2v5ecg	261	2	treatment	treatment	NN
cord-285091-2i2v5ecg	261	3	of	of	IN
cord-285091-2i2v5ecg	261	4	Ebola	Ebola	NNP
cord-285091-2i2v5ecg	261	5	virus	virus	NN
cord-285091-2i2v5ecg	261	6	-	-	HYPH
cord-285091-2i2v5ecg	261	7	infected	infect	VBN
cord-285091-2i2v5ecg	261	8	cynomolgus	cynomolgus	JJ
cord-285091-2i2v5ecg	261	9	macaques	macaque	NNS
cord-285091-2i2v5ecg	261	10	with	with	IN
cord-285091-2i2v5ecg	261	11	monoclonal	monoclonal	JJ
cord-285091-2i2v5ecg	261	12	antibodies	antibody	NNS
cord-285091-2i2v5ecg	262	1	Proteasemediated	proteasemediate	VBN
cord-285091-2i2v5ecg	262	2	entry	entry	NN
cord-285091-2i2v5ecg	262	3	via	via	IN
cord-285091-2i2v5ecg	262	4	the	the	DT
cord-285091-2i2v5ecg	262	5	endosome	endosome	NN
cord-285091-2i2v5ecg	262	6	of	of	IN
cord-285091-2i2v5ecg	262	7	human	human	JJ
cord-285091-2i2v5ecg	262	8	Coronavirus	Coronavirus	NNP
cord-285091-2i2v5ecg	262	9	229E	229e	CD
cord-285091-2i2v5ecg	262	10	Inhibitors	Inhibitors	NNP
cord-285091-2i2v5ecg	262	11	of	of	IN
cord-285091-2i2v5ecg	262	12	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	263	1	L	l	NN
cord-285091-2i2v5ecg	263	2	prevent	prevent	VBP
cord-285091-2i2v5ecg	263	3	severe	severe	JJ
cord-285091-2i2v5ecg	263	4	acute	acute	JJ
cord-285091-2i2v5ecg	263	5	respiratory	respiratory	JJ
cord-285091-2i2v5ecg	263	6	syndrome	syndrome	NN
cord-285091-2i2v5ecg	263	7	coronavirus	coronavirus	NN
cord-285091-2i2v5ecg	263	8	entry	entry	NN
cord-285091-2i2v5ecg	263	9	Activation	Activation	NNP
cord-285091-2i2v5ecg	263	10	of	of	IN
cord-285091-2i2v5ecg	263	11	the	the	DT
cord-285091-2i2v5ecg	263	12	sars	sars	NNP
cord-285091-2i2v5ecg	263	13	coronavirus	coronavirus	NN
cord-285091-2i2v5ecg	263	14	spike	spike	NN
cord-285091-2i2v5ecg	263	15	protein	protein	NN
cord-285091-2i2v5ecg	263	16	via	via	IN
cord-285091-2i2v5ecg	263	17	sequential	sequential	JJ
cord-285091-2i2v5ecg	263	18	proteolytic	proteolytic	JJ
cord-285091-2i2v5ecg	263	19	cleavage	cleavage	NN
cord-285091-2i2v5ecg	263	20	at	at	IN
cord-285091-2i2v5ecg	263	21	two	two	CD
cord-285091-2i2v5ecg	263	22	distinct	distinct	JJ
cord-285091-2i2v5ecg	263	23	sites	site	NNS
cord-285091-2i2v5ecg	263	24	Sars	Sars	NNP
cord-285091-2i2v5ecg	263	25	coronavirus	coronavirus	NN
cord-285091-2i2v5ecg	263	26	,	,	,
cord-285091-2i2v5ecg	263	27	but	but	CC
cord-285091-2i2v5ecg	263	28	not	not	RB
cord-285091-2i2v5ecg	263	29	human	human	JJ
cord-285091-2i2v5ecg	263	30	Coronavirus	Coronavirus	NNP
cord-285091-2i2v5ecg	263	31	Nl63	Nl63	.
cord-285091-2i2v5ecg	264	1	,	,	,
cord-285091-2i2v5ecg	264	2	Utilizes	utilize	VBZ
cord-285091-2i2v5ecg	264	3	Cathepsin	Cathepsin	NNP
cord-285091-2i2v5ecg	264	4	L	L	NNP
cord-285091-2i2v5ecg	264	5	to	to	TO
cord-285091-2i2v5ecg	264	6	Infect	infect	VB
cord-285091-2i2v5ecg	264	7	ACE2-expressing	ace2-expressing	NN
cord-285091-2i2v5ecg	264	8	cells	cell	NNS
cord-285091-2i2v5ecg	264	9	Isolation	isolation	NN
cord-285091-2i2v5ecg	264	10	and	and	CC
cord-285091-2i2v5ecg	264	11	characterization	characterization	NN
cord-285091-2i2v5ecg	264	12	of	of	IN
cord-285091-2i2v5ecg	264	13	viruses	virus	NNS
cord-285091-2i2v5ecg	264	14	related	relate	VBN
cord-285091-2i2v5ecg	264	15	to	to	IN
cord-285091-2i2v5ecg	264	16	the	the	DT
cord-285091-2i2v5ecg	264	17	SARS	SARS	NNP
cord-285091-2i2v5ecg	264	18	coronavirus	coronavirus	NN
cord-285091-2i2v5ecg	264	19	from	from	IN
cord-285091-2i2v5ecg	264	20	animals	animal	NNS
cord-285091-2i2v5ecg	264	21	in	in	IN
cord-285091-2i2v5ecg	264	22	southern	southern	JJ
cord-285091-2i2v5ecg	264	23	China	China	NNP
cord-285091-2i2v5ecg	264	24	Fully	fully	RB
cord-285091-2i2v5ecg	264	25	human	human	JJ
cord-285091-2i2v5ecg	264	26	monoclonal	monoclonal	JJ
cord-285091-2i2v5ecg	264	27	antibody	antibody	NN
cord-285091-2i2v5ecg	264	28	directed	direct	VBN
cord-285091-2i2v5ecg	264	29	to	to	IN
cord-285091-2i2v5ecg	264	30	proteolytic	proteolytic	JJ
cord-285091-2i2v5ecg	264	31	cleavage	cleavage	NN
cord-285091-2i2v5ecg	264	32	site	site	NN
cord-285091-2i2v5ecg	264	33	in	in	IN
cord-285091-2i2v5ecg	264	34	severe	severe	JJ
cord-285091-2i2v5ecg	264	35	acute	acute	JJ
cord-285091-2i2v5ecg	264	36	respiratory	respiratory	JJ
cord-285091-2i2v5ecg	264	37	syndrome	syndrome	NN
cord-285091-2i2v5ecg	264	38	(	(	-LRB-
cord-285091-2i2v5ecg	264	39	SARS	SARS	NNP
cord-285091-2i2v5ecg	264	40	)	)	-RRB-
cord-285091-2i2v5ecg	265	1	Coronavirus	Coronavirus	NNP
cord-285091-2i2v5ecg	265	2	S	S	NNP
cord-285091-2i2v5ecg	265	3	Protein	Protein	NNP
cord-285091-2i2v5ecg	265	4	Neutralizes	neutralize	VBZ
cord-285091-2i2v5ecg	265	5	the	the	DT
cord-285091-2i2v5ecg	265	6	Virus	virus	NN
cord-285091-2i2v5ecg	265	7	in	in	IN
cord-285091-2i2v5ecg	265	8	a	a	DT
cord-285091-2i2v5ecg	265	9	Rhesus	Rhesus	NNP
cord-285091-2i2v5ecg	265	10	Macaque	Macaque	NNP
cord-285091-2i2v5ecg	265	11	SARS	SARS	NNP
cord-285091-2i2v5ecg	265	12	Model	Model	NNP
cord-285091-2i2v5ecg	265	13	Paramyxovirus	Paramyxovirus	NNP
cord-285091-2i2v5ecg	265	14	fusion	fusion	NN
cord-285091-2i2v5ecg	265	15	and	and	CC
cord-285091-2i2v5ecg	265	16	entry	entry	NN
cord-285091-2i2v5ecg	265	17	:	:	:
cord-285091-2i2v5ecg	266	1	Multiple	multiple	JJ
cord-285091-2i2v5ecg	266	2	paths	path	NNS
cord-285091-2i2v5ecg	266	3	to	to	IN
cord-285091-2i2v5ecg	266	4	a	a	DT
cord-285091-2i2v5ecg	266	5	common	common	JJ
cord-285091-2i2v5ecg	266	6	end	end	NN
cord-285091-2i2v5ecg	266	7	Activation	activation	NN
cord-285091-2i2v5ecg	266	8	of	of	IN
cord-285091-2i2v5ecg	266	9	the	the	DT
cord-285091-2i2v5ecg	266	10	Nipah	Nipah	NNP
cord-285091-2i2v5ecg	266	11	virus	virus	NN
cord-285091-2i2v5ecg	266	12	fusion	fusion	NN
cord-285091-2i2v5ecg	266	13	protein	protein	NN
cord-285091-2i2v5ecg	266	14	in	in	IN
cord-285091-2i2v5ecg	266	15	MDCK	MDCK	NNP
cord-285091-2i2v5ecg	266	16	cells	cell	NNS
cord-285091-2i2v5ecg	266	17	is	be	VBZ
cord-285091-2i2v5ecg	266	18	mediated	mediate	VBN
cord-285091-2i2v5ecg	266	19	by	by	IN
cord-285091-2i2v5ecg	266	20	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	266	21	B	b	NN
cord-285091-2i2v5ecg	266	22	within	within	IN
cord-285091-2i2v5ecg	266	23	the	the	DT
cord-285091-2i2v5ecg	266	24	endosome	endosome	NN
cord-285091-2i2v5ecg	266	25	-	-	HYPH
cord-285091-2i2v5ecg	266	26	recycling	recycle	VBG
cord-285091-2i2v5ecg	266	27	compartment	compartment	NN
cord-285091-2i2v5ecg	266	28	Protein	Protein	NNP
cord-285091-2i2v5ecg	266	29	1	1	CD
cord-285091-2i2v5ecg	267	1	is	be	VBZ
cord-285091-2i2v5ecg	267	2	the	the	DT
cord-285091-2i2v5ecg	267	3	reovirus	reovirus	NNP
cord-285091-2i2v5ecg	267	4	cell	cell	NN
cord-285091-2i2v5ecg	267	5	attachment	attachment	NN
cord-285091-2i2v5ecg	267	6	protein	protein	NN
cord-285091-2i2v5ecg	267	7	Evidence	evidence	NN
cord-285091-2i2v5ecg	267	8	for	for	IN
cord-285091-2i2v5ecg	267	9	a	a	DT
cord-285091-2i2v5ecg	267	10	second	second	JJ
cord-285091-2i2v5ecg	267	11	step	step	NN
cord-285091-2i2v5ecg	267	12	in	in	IN
cord-285091-2i2v5ecg	267	13	the	the	DT
cord-285091-2i2v5ecg	267	14	intracellular	intracellular	JJ
cord-285091-2i2v5ecg	267	15	uncoating	uncoating	NN
cord-285091-2i2v5ecg	267	16	and	and	CC
cord-285091-2i2v5ecg	267	17	transcriptase	transcriptase	NN
cord-285091-2i2v5ecg	267	18	activation	activation	NN
cord-285091-2i2v5ecg	267	19	process	process	NN
cord-285091-2i2v5ecg	268	1	Genetic	genetic	JJ
cord-285091-2i2v5ecg	268	2	and	and	CC
cord-285091-2i2v5ecg	268	3	pharmacologic	pharmacologic	JJ
cord-285091-2i2v5ecg	268	4	alteration	alteration	NN
cord-285091-2i2v5ecg	268	5	of	of	IN
cord-285091-2i2v5ecg	268	6	cathepsin	cathepsin	NN
cord-285091-2i2v5ecg	268	7	expression	expression	NN
cord-285091-2i2v5ecg	268	8	influences	influence	VBZ
cord-285091-2i2v5ecg	268	9	reovirus	reovirus	NNP
cord-285091-2i2v5ecg	268	10	pathogenesis	pathogenesis	NN
cord-285091-2i2v5ecg	269	1	This	this	DT
cord-285091-2i2v5ecg	269	2	work	work	NN
cord-285091-2i2v5ecg	269	3	is	be	VBZ
cord-285091-2i2v5ecg	269	4	supported	support	VBN
cord-285091-2i2v5ecg	269	5	by	by	IN
cord-285091-2i2v5ecg	269	6	grants	grant	NNS
cord-285091-2i2v5ecg	269	7	from	from	IN
cord-285091-2i2v5ecg	269	8	Slovenian	Slovenian	NNP
cord-285091-2i2v5ecg	269	9	Research	Research	NNP
cord-285091-2i2v5ecg	269	10	Agency	Agency	NNP
cord-285091-2i2v5ecg	269	11	:	:	:
cord-285091-2i2v5ecg	269	12	grant	grant	VB
cord-285091-2i2v5ecg	269	13	J3	J3	NNP
cord-285091-2i2v5ecg	269	14	-	-	HYPH
cord-285091-2i2v5ecg	269	15	0612	0612	CD
cord-285091-2i2v5ecg	270	1	(	(	-LRB-
cord-285091-2i2v5ecg	270	2	to	to	IN
cord-285091-2i2v5ecg	270	3	N.	N.	NNP
cord-285091-2i2v5ecg	270	4	Kopitar	Kopitar	NNP
cord-285091-2i2v5ecg	270	5	-	-	HYPH
cord-285091-2i2v5ecg	270	6	Jerala	Jerala	NNP
cord-285091-2i2v5ecg	270	7	)	)	-RRB-
cord-285091-2i2v5ecg	270	8	,	,	,
cord-285091-2i2v5ecg	270	9	grant	grant	NN
cord-285091-2i2v5ecg	270	10	P-0140	p-0140	CD
cord-285091-2i2v5ecg	270	11	(	(	-LRB-
cord-285091-2i2v5ecg	270	12	to	to	IN
cord-285091-2i2v5ecg	270	13	B.	B.	NNP
cord-285091-2i2v5ecg	270	14	Turk	Turk	NNP
cord-285091-2i2v5ecg	270	15	)	)	-RRB-
cord-285091-2i2v5ecg	270	16	and	and	CC
cord-285091-2i2v5ecg	270	17	grant	grant	VB
cord-285091-2i2v5ecg	270	18	J1	J1	NNP
cord-285091-2i2v5ecg	270	19	-	-	HYPH
cord-285091-2i2v5ecg	270	20	4170	4170	CD
cord-285091-2i2v5ecg	270	21	.	.	.