id	sid	tid	token	lemma	pos
cord-296347-fanlvxqs	1	1	key	key	JJ
cord-296347-fanlvxqs	1	2	:	:	:
cord-296347-fanlvxqs	1	3	cord-296347-fanlvxqs	cord-296347-fanlvxqs	NNP
cord-296347-fanlvxqs	2	1	authors	author	NNS
cord-296347-fanlvxqs	2	2	:	:	:
cord-296347-fanlvxqs	2	3	Loureiro	Loureiro	NNP
cord-296347-fanlvxqs	2	4	,	,	,
cord-296347-fanlvxqs	2	5	Joana	Joana	NNP
cord-296347-fanlvxqs	2	6	;	;	:
cord-296347-fanlvxqs	2	7	Ploegh	Ploegh	NNP
cord-296347-fanlvxqs	2	8	,	,	,
cord-296347-fanlvxqs	2	9	Hidde	Hidde	NNP
cord-296347-fanlvxqs	2	10	L.	L.	NNP
cord-296347-fanlvxqs	2	11	title	title	NN
cord-296347-fanlvxqs	2	12	:	:	:
cord-296347-fanlvxqs	2	13	Antigen	Antigen	NNP
cord-296347-fanlvxqs	2	14	Presentation	Presentation	NNP
cord-296347-fanlvxqs	2	15	and	and	CC
cord-296347-fanlvxqs	2	16	the	the	DT
cord-296347-fanlvxqs	2	17	Ubiquitin‐Proteasome	Ubiquitin‐Proteasome	NNP
cord-296347-fanlvxqs	2	18	System	System	NNP
cord-296347-fanlvxqs	2	19	in	in	IN
cord-296347-fanlvxqs	2	20	Host	Host	NNP
cord-296347-fanlvxqs	2	21	–	–	:
cord-296347-fanlvxqs	2	22	Pathogen	Pathogen	NNP
cord-296347-fanlvxqs	2	23	Interactions	Interactions	NNPS
cord-296347-fanlvxqs	2	24	date	date	NN
cord-296347-fanlvxqs	2	25	:	:	:
cord-296347-fanlvxqs	2	26	2006	2006	CD
cord-296347-fanlvxqs	2	27	-	-	SYM
cord-296347-fanlvxqs	2	28	12	12	CD
cord-296347-fanlvxqs	2	29	-	-	SYM
cord-296347-fanlvxqs	2	30	02	02	CD
cord-296347-fanlvxqs	2	31	journal	journal	NN
cord-296347-fanlvxqs	2	32	:	:	:
cord-296347-fanlvxqs	3	1	Adv	Adv	NNP
cord-296347-fanlvxqs	3	2	Immunol	Immunol	NNP
cord-296347-fanlvxqs	3	3	DOI	DOI	NNP
cord-296347-fanlvxqs	3	4	:	:	:
cord-296347-fanlvxqs	3	5	10.1016	10.1016	CD
cord-296347-fanlvxqs	3	6	/	/	SYM
cord-296347-fanlvxqs	3	7	s0065	s0065	NNP
cord-296347-fanlvxqs	3	8	-	-	HYPH
cord-296347-fanlvxqs	3	9	2776(06)92006	2776(06)92006	CD
cord-296347-fanlvxqs	3	10	-	-	SYM
cord-296347-fanlvxqs	3	11	9	9	CD
cord-296347-fanlvxqs	3	12	sha	sha	NN
cord-296347-fanlvxqs	3	13	:	:	:
cord-296347-fanlvxqs	3	14	276cfd64618fb1aebf7050880805c550149b310f	276cfd64618fb1aebf7050880805c550149b310f	CD
cord-296347-fanlvxqs	3	15	doc_id	doc_id	CD
cord-296347-fanlvxqs	3	16	:	:	:
cord-296347-fanlvxqs	3	17	296347	296347	CD
cord-296347-fanlvxqs	3	18	cord_uid	cord_uid	NNS
cord-296347-fanlvxqs	3	19	:	:	:
cord-296347-fanlvxqs	3	20	fanlvxqs	fanlvxqs	NNP
cord-296347-fanlvxqs	3	21	Relatively	relatively	RB
cord-296347-fanlvxqs	3	22	small	small	JJ
cord-296347-fanlvxqs	3	23	genomes	genome	NNS
cord-296347-fanlvxqs	3	24	and	and	CC
cord-296347-fanlvxqs	3	25	high	high	JJ
cord-296347-fanlvxqs	3	26	replication	replication	NN
cord-296347-fanlvxqs	3	27	rates	rate	NNS
cord-296347-fanlvxqs	3	28	allow	allow	VBP
cord-296347-fanlvxqs	3	29	viruses	virus	NNS
cord-296347-fanlvxqs	3	30	and	and	CC
cord-296347-fanlvxqs	3	31	bacteria	bacteria	NNS
cord-296347-fanlvxqs	3	32	to	to	TO
cord-296347-fanlvxqs	3	33	accumulate	accumulate	VB
cord-296347-fanlvxqs	3	34	mutations	mutation	NNS
cord-296347-fanlvxqs	3	35	.	.	.
cord-296347-fanlvxqs	4	1	This	this	DT
cord-296347-fanlvxqs	4	2	continuously	continuously	RB
cord-296347-fanlvxqs	4	3	presents	present	VBZ
cord-296347-fanlvxqs	4	4	the	the	DT
cord-296347-fanlvxqs	4	5	host	host	NN
cord-296347-fanlvxqs	4	6	immune	immune	JJ
cord-296347-fanlvxqs	4	7	system	system	NN
cord-296347-fanlvxqs	4	8	with	with	IN
cord-296347-fanlvxqs	4	9	new	new	JJ
cord-296347-fanlvxqs	4	10	challenges	challenge	NNS
cord-296347-fanlvxqs	4	11	.	.	.
cord-296347-fanlvxqs	5	1	On	on	IN
cord-296347-fanlvxqs	5	2	the	the	DT
cord-296347-fanlvxqs	5	3	other	other	JJ
cord-296347-fanlvxqs	5	4	side	side	NN
cord-296347-fanlvxqs	5	5	of	of	IN
cord-296347-fanlvxqs	5	6	the	the	DT
cord-296347-fanlvxqs	5	7	trenches	trench	NNS
cord-296347-fanlvxqs	5	8	,	,	,
cord-296347-fanlvxqs	5	9	an	an	DT
cord-296347-fanlvxqs	5	10	increasingly	increasingly	RB
cord-296347-fanlvxqs	5	11	well‐adjusted	well‐adjusted	JJ
cord-296347-fanlvxqs	5	12	host	host	NN
cord-296347-fanlvxqs	5	13	immune	immune	JJ
cord-296347-fanlvxqs	5	14	response	response	NN
cord-296347-fanlvxqs	5	15	,	,	,
cord-296347-fanlvxqs	5	16	shaped	shape	VBN
cord-296347-fanlvxqs	5	17	by	by	IN
cord-296347-fanlvxqs	5	18	coevolutionary	coevolutionary	JJ
cord-296347-fanlvxqs	5	19	history	history	NN
cord-296347-fanlvxqs	5	20	,	,	,
cord-296347-fanlvxqs	5	21	makes	make	VBZ
cord-296347-fanlvxqs	5	22	a	a	DT
cord-296347-fanlvxqs	5	23	pathogen	pathogen	NN
cord-296347-fanlvxqs	5	24	's	's	POS
cord-296347-fanlvxqs	5	25	life	life	NN
cord-296347-fanlvxqs	5	26	a	a	DT
cord-296347-fanlvxqs	5	27	rather	rather	RB
cord-296347-fanlvxqs	5	28	complicated	complicated	JJ
cord-296347-fanlvxqs	5	29	endeavor	endeavor	NN
cord-296347-fanlvxqs	5	30	.	.	.
cord-296347-fanlvxqs	6	1	It	-PRON-	PRP
cord-296347-fanlvxqs	6	2	is	be	VBZ
cord-296347-fanlvxqs	6	3	,	,	,
cord-296347-fanlvxqs	6	4	therefore	therefore	RB
cord-296347-fanlvxqs	6	5	,	,	,
cord-296347-fanlvxqs	6	6	no	no	DT
cord-296347-fanlvxqs	6	7	surprise	surprise	NN
cord-296347-fanlvxqs	6	8	that	that	IN
cord-296347-fanlvxqs	6	9	pathogens	pathogen	NNS
cord-296347-fanlvxqs	6	10	either	either	CC
cord-296347-fanlvxqs	6	11	escape	escape	VB
cord-296347-fanlvxqs	6	12	detection	detection	NN
cord-296347-fanlvxqs	6	13	or	or	CC
cord-296347-fanlvxqs	6	14	modulate	modulate	VB
cord-296347-fanlvxqs	6	15	the	the	DT
cord-296347-fanlvxqs	6	16	host	host	NN
cord-296347-fanlvxqs	6	17	immune	immune	JJ
cord-296347-fanlvxqs	6	18	response	response	NN
cord-296347-fanlvxqs	6	19	,	,	,
cord-296347-fanlvxqs	6	20	often	often	RB
cord-296347-fanlvxqs	6	21	by	by	IN
cord-296347-fanlvxqs	6	22	redirecting	redirect	VBG
cord-296347-fanlvxqs	6	23	normal	normal	JJ
cord-296347-fanlvxqs	6	24	cellular	cellular	JJ
cord-296347-fanlvxqs	6	25	pathways	pathway	NNS
cord-296347-fanlvxqs	6	26	to	to	IN
cord-296347-fanlvxqs	6	27	their	-PRON-	PRP$
cord-296347-fanlvxqs	6	28	advantage	advantage	NN
cord-296347-fanlvxqs	6	29	.	.	.
cord-296347-fanlvxqs	7	1	For	for	IN
cord-296347-fanlvxqs	7	2	the	the	DT
cord-296347-fanlvxqs	7	3	purpose	purpose	NN
cord-296347-fanlvxqs	7	4	of	of	IN
cord-296347-fanlvxqs	7	5	this	this	DT
cord-296347-fanlvxqs	7	6	chapter	chapter	NN
cord-296347-fanlvxqs	7	7	,	,	,
cord-296347-fanlvxqs	7	8	we	-PRON-	PRP
cord-296347-fanlvxqs	7	9	focus	focus	VBP
cord-296347-fanlvxqs	7	10	mainly	mainly	RB
cord-296347-fanlvxqs	7	11	on	on	IN
cord-296347-fanlvxqs	7	12	the	the	DT
cord-296347-fanlvxqs	7	13	manipulation	manipulation	NN
cord-296347-fanlvxqs	7	14	of	of	IN
cord-296347-fanlvxqs	7	15	the	the	DT
cord-296347-fanlvxqs	7	16	class	class	NN
cord-296347-fanlvxqs	7	17	I	i	NN
cord-296347-fanlvxqs	7	18	and	and	CC
cord-296347-fanlvxqs	7	19	class	class	NN
cord-296347-fanlvxqs	7	20	II	ii	NN
cord-296347-fanlvxqs	8	1	major	major	JJ
cord-296347-fanlvxqs	8	2	histocompatibility	histocompatibility	NN
cord-296347-fanlvxqs	8	3	complex	complex	NN
cord-296347-fanlvxqs	8	4	(	(	-LRB-
cord-296347-fanlvxqs	8	5	MHC	MHC	NNP
cord-296347-fanlvxqs	8	6	)	)	-RRB-
cord-296347-fanlvxqs	8	7	antigen	antigen	NN
cord-296347-fanlvxqs	8	8	presentation	presentation	NN
cord-296347-fanlvxqs	8	9	pathways	pathway	NNS
cord-296347-fanlvxqs	8	10	and	and	CC
cord-296347-fanlvxqs	8	11	the	the	DT
cord-296347-fanlvxqs	8	12	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	8	13	(	(	-LRB-
cord-296347-fanlvxqs	8	14	Ub)‐proteasome	ub)‐proteasome	NN
cord-296347-fanlvxqs	8	15	system	system	NN
cord-296347-fanlvxqs	8	16	by	by	IN
cord-296347-fanlvxqs	8	17	both	both	DT
cord-296347-fanlvxqs	8	18	viral	viral	JJ
cord-296347-fanlvxqs	8	19	and	and	CC
cord-296347-fanlvxqs	8	20	bacterial	bacterial	JJ
cord-296347-fanlvxqs	8	21	pathogens	pathogen	NNS
cord-296347-fanlvxqs	8	22	.	.	.
cord-296347-fanlvxqs	9	1	First	first	RB
cord-296347-fanlvxqs	9	2	,	,	,
cord-296347-fanlvxqs	9	3	we	-PRON-	PRP
cord-296347-fanlvxqs	9	4	describe	describe	VBP
cord-296347-fanlvxqs	9	5	the	the	DT
cord-296347-fanlvxqs	9	6	general	general	JJ
cord-296347-fanlvxqs	9	7	features	feature	NNS
cord-296347-fanlvxqs	9	8	of	of	IN
cord-296347-fanlvxqs	9	9	antigen	antigen	NN
cord-296347-fanlvxqs	9	10	presentation	presentation	NN
cord-296347-fanlvxqs	9	11	pathways	pathway	NNS
cord-296347-fanlvxqs	9	12	and	and	CC
cord-296347-fanlvxqs	9	13	the	the	DT
cord-296347-fanlvxqs	9	14	Ub‐proteasome	Ub‐proteasome	VBN
cord-296347-fanlvxqs	9	15	system	system	NN
cord-296347-fanlvxqs	9	16	and	and	CC
cord-296347-fanlvxqs	9	17	then	then	RB
cord-296347-fanlvxqs	9	18	address	address	VB
cord-296347-fanlvxqs	9	19	how	how	WRB
cord-296347-fanlvxqs	9	20	they	-PRON-	PRP
cord-296347-fanlvxqs	9	21	are	be	VBP
cord-296347-fanlvxqs	9	22	manipulated	manipulate	VBN
cord-296347-fanlvxqs	9	23	by	by	IN
cord-296347-fanlvxqs	9	24	pathogens	pathogen	NNS
cord-296347-fanlvxqs	9	25	.	.	.
cord-296347-fanlvxqs	10	1	We	-PRON-	PRP
cord-296347-fanlvxqs	10	2	discuss	discuss	VBP
cord-296347-fanlvxqs	10	3	the	the	DT
cord-296347-fanlvxqs	10	4	many	many	JJ
cord-296347-fanlvxqs	10	5	human	human	JJ
cord-296347-fanlvxqs	10	6	cytomegalovirus	cytomegalovirus	NN
cord-296347-fanlvxqs	10	7	(	(	-LRB-
cord-296347-fanlvxqs	10	8	HCMV)‐encoded	hcmv)‐encoded	JJ
cord-296347-fanlvxqs	10	9	immunomodulatory	immunomodulatory	JJ
cord-296347-fanlvxqs	10	10	genes	gene	NNS
cord-296347-fanlvxqs	10	11	that	that	WDT
cord-296347-fanlvxqs	10	12	interfere	interfere	VBP
cord-296347-fanlvxqs	10	13	with	with	IN
cord-296347-fanlvxqs	10	14	antigen	antigen	NN
cord-296347-fanlvxqs	10	15	presentation	presentation	NN
cord-296347-fanlvxqs	10	16	(	(	-LRB-
cord-296347-fanlvxqs	10	17	immunoevasins	immunoevasins	NNP
cord-296347-fanlvxqs	10	18	)	)	-RRB-
cord-296347-fanlvxqs	10	19	and	and	CC
cord-296347-fanlvxqs	10	20	focus	focus	VB
cord-296347-fanlvxqs	10	21	on	on	IN
cord-296347-fanlvxqs	10	22	the	the	DT
cord-296347-fanlvxqs	10	23	HCMV	HCMV	NNP
cord-296347-fanlvxqs	10	24	immunoevasins	immunoevasin	NNS
cord-296347-fanlvxqs	10	25	US2	US2	NNP
cord-296347-fanlvxqs	10	26	and	and	CC
cord-296347-fanlvxqs	10	27	US11	US11	NNP
cord-296347-fanlvxqs	10	28	,	,	,
cord-296347-fanlvxqs	10	29	which	which	WDT
cord-296347-fanlvxqs	10	30	induce	induce	VBP
cord-296347-fanlvxqs	10	31	the	the	DT
cord-296347-fanlvxqs	10	32	degradation	degradation	NN
cord-296347-fanlvxqs	10	33	of	of	IN
cord-296347-fanlvxqs	10	34	class	class	NN
cord-296347-fanlvxqs	11	1	I	-PRON-	PRP
cord-296347-fanlvxqs	11	2	MHC	MHC	NNP
cord-296347-fanlvxqs	11	3	heavy	heavy	JJ
cord-296347-fanlvxqs	11	4	chains	chain	NNS
cord-296347-fanlvxqs	11	5	by	by	IN
cord-296347-fanlvxqs	11	6	the	the	DT
cord-296347-fanlvxqs	11	7	proteasome	proteasome	NN
cord-296347-fanlvxqs	11	8	by	by	IN
cord-296347-fanlvxqs	11	9	catalyzing	catalyze	VBG
cord-296347-fanlvxqs	11	10	their	-PRON-	PRP$
cord-296347-fanlvxqs	11	11	export	export	NN
cord-296347-fanlvxqs	11	12	from	from	IN
cord-296347-fanlvxqs	11	13	the	the	DT
cord-296347-fanlvxqs	11	14	endoplasmic	endoplasmic	NN
cord-296347-fanlvxqs	11	15	reticulum	reticulum	NN
cord-296347-fanlvxqs	11	16	(	(	-LRB-
cord-296347-fanlvxqs	11	17	ER)‐membrane	ER)‐membrane	NNP
cord-296347-fanlvxqs	11	18	into	into	IN
cord-296347-fanlvxqs	11	19	the	the	DT
cord-296347-fanlvxqs	11	20	cytosol	cytosol	NN
cord-296347-fanlvxqs	11	21	,	,	,
cord-296347-fanlvxqs	11	22	a	a	DT
cord-296347-fanlvxqs	11	23	process	process	NN
cord-296347-fanlvxqs	11	24	termed	term	VBN
cord-296347-fanlvxqs	11	25	ER	ER	NNP
cord-296347-fanlvxqs	11	26	dislocation	dislocation	NN
cord-296347-fanlvxqs	11	27	.	.	.
cord-296347-fanlvxqs	12	1	US2‐	us2‐	JJ
cord-296347-fanlvxqs	12	2	and	and	CC
cord-296347-fanlvxqs	12	3	US11‐mediated	us11‐mediated	JJ
cord-296347-fanlvxqs	12	4	subversion	subversion	NN
cord-296347-fanlvxqs	12	5	of	of	IN
cord-296347-fanlvxqs	12	6	ER	ER	NNP
cord-296347-fanlvxqs	12	7	dislocation	dislocation	NN
cord-296347-fanlvxqs	12	8	ensures	ensure	VBZ
cord-296347-fanlvxqs	12	9	proteasomal	proteasomal	JJ
cord-296347-fanlvxqs	12	10	degradation	degradation	NN
cord-296347-fanlvxqs	12	11	of	of	IN
cord-296347-fanlvxqs	12	12	class	class	NN
cord-296347-fanlvxqs	12	13	I	-PRON-	PRP
cord-296347-fanlvxqs	12	14	MHC	MHC	NNP
cord-296347-fanlvxqs	12	15	molecules	molecule	NNS
cord-296347-fanlvxqs	12	16	and	and	CC
cord-296347-fanlvxqs	12	17	presumably	presumably	RB
cord-296347-fanlvxqs	12	18	allows	allow	VBZ
cord-296347-fanlvxqs	12	19	HCMV	HCMV	NNP
cord-296347-fanlvxqs	12	20	to	to	TO
cord-296347-fanlvxqs	12	21	avoid	avoid	VB
cord-296347-fanlvxqs	12	22	recognition	recognition	NN
cord-296347-fanlvxqs	12	23	by	by	IN
cord-296347-fanlvxqs	12	24	cytotoxic	cytotoxic	JJ
cord-296347-fanlvxqs	12	25	T	t	NN
cord-296347-fanlvxqs	12	26	cells	cell	NNS
cord-296347-fanlvxqs	12	27	,	,	,
cord-296347-fanlvxqs	12	28	whilst	whilst	IN
cord-296347-fanlvxqs	12	29	providing	provide	VBG
cord-296347-fanlvxqs	12	30	insight	insight	NN
cord-296347-fanlvxqs	12	31	into	into	IN
cord-296347-fanlvxqs	12	32	general	general	JJ
cord-296347-fanlvxqs	12	33	aspects	aspect	NNS
cord-296347-fanlvxqs	12	34	of	of	IN
cord-296347-fanlvxqs	12	35	ER‐associated	ER‐associated	NNP
cord-296347-fanlvxqs	12	36	degradation	degradation	NN
cord-296347-fanlvxqs	12	37	(	(	-LRB-
cord-296347-fanlvxqs	12	38	ERAD	ERAD	NNP
cord-296347-fanlvxqs	12	39	)	)	-RRB-
cord-296347-fanlvxqs	12	40	which	which	WDT
cord-296347-fanlvxqs	12	41	is	be	VBZ
cord-296347-fanlvxqs	12	42	used	use	VBN
cord-296347-fanlvxqs	12	43	by	by	IN
cord-296347-fanlvxqs	12	44	eukaryotic	eukaryotic	JJ
cord-296347-fanlvxqs	12	45	cells	cell	NNS
cord-296347-fanlvxqs	12	46	to	to	TO
cord-296347-fanlvxqs	12	47	purge	purge	VB
cord-296347-fanlvxqs	12	48	their	-PRON-	PRP$
cord-296347-fanlvxqs	12	49	ER	er	NN
cord-296347-fanlvxqs	12	50	of	of	IN
cord-296347-fanlvxqs	12	51	defective	defective	JJ
cord-296347-fanlvxqs	12	52	proteins	protein	NNS
cord-296347-fanlvxqs	12	53	.	.	.
cord-296347-fanlvxqs	13	1	We	-PRON-	PRP
cord-296347-fanlvxqs	13	2	discuss	discuss	VBP
cord-296347-fanlvxqs	13	3	the	the	DT
cord-296347-fanlvxqs	13	4	similarities	similarity	NNS
cord-296347-fanlvxqs	13	5	and	and	CC
cord-296347-fanlvxqs	13	6	differences	difference	NNS
cord-296347-fanlvxqs	13	7	between	between	IN
cord-296347-fanlvxqs	13	8	the	the	DT
cord-296347-fanlvxqs	13	9	distinct	distinct	JJ
cord-296347-fanlvxqs	13	10	pathways	pathway	NNS
cord-296347-fanlvxqs	13	11	co‐opted	co‐opte	VBN
cord-296347-fanlvxqs	13	12	by	by	IN
cord-296347-fanlvxqs	13	13	US2	US2	NNP
cord-296347-fanlvxqs	13	14	and	and	CC
cord-296347-fanlvxqs	13	15	US11	US11	NNP
cord-296347-fanlvxqs	13	16	for	for	IN
cord-296347-fanlvxqs	13	17	dislocation	dislocation	NN
cord-296347-fanlvxqs	13	18	and	and	CC
cord-296347-fanlvxqs	13	19	degradation	degradation	NN
cord-296347-fanlvxqs	13	20	of	of	IN
cord-296347-fanlvxqs	13	21	human	human	JJ
cord-296347-fanlvxqs	13	22	class	class	NN
cord-296347-fanlvxqs	13	23	I	-PRON-	PRP
cord-296347-fanlvxqs	13	24	MHC	MHC	NNP
cord-296347-fanlvxqs	13	25	molecules	molecule	NNS
cord-296347-fanlvxqs	13	26	and	and	CC
cord-296347-fanlvxqs	13	27	also	also	RB
cord-296347-fanlvxqs	13	28	a	a	DT
cord-296347-fanlvxqs	13	29	putatively	putatively	RB
cord-296347-fanlvxqs	13	30	distinct	distinct	JJ
cord-296347-fanlvxqs	13	31	pathway	pathway	NN
cord-296347-fanlvxqs	13	32	utilized	utilize	VBN
cord-296347-fanlvxqs	13	33	by	by	IN
cord-296347-fanlvxqs	13	34	the	the	DT
cord-296347-fanlvxqs	13	35	murine	murine	JJ
cord-296347-fanlvxqs	13	36	herpes	herpes	NNP
cord-296347-fanlvxqs	13	37	virus	virus	NN
cord-296347-fanlvxqs	13	38	(	(	-LRB-
cord-296347-fanlvxqs	13	39	MHV)‐68	MHV)‐68	NNP
cord-296347-fanlvxqs	13	40	mK3	mK3	NNP
cord-296347-fanlvxqs	13	41	immunoevasin	immunoevasin	NNP
cord-296347-fanlvxqs	13	42	for	for	IN
cord-296347-fanlvxqs	13	43	ER	ER	NNP
cord-296347-fanlvxqs	13	44	dislocation	dislocation	NN
cord-296347-fanlvxqs	13	45	of	of	IN
cord-296347-fanlvxqs	13	46	murine	murine	JJ
cord-296347-fanlvxqs	13	47	class	class	NN
cord-296347-fanlvxqs	14	1	I	-PRON-	PRP
cord-296347-fanlvxqs	14	2	MHC	MHC	NNP
cord-296347-fanlvxqs	14	3	.	.	.
cord-296347-fanlvxqs	15	1	We	-PRON-	PRP
cord-296347-fanlvxqs	15	2	speculate	speculate	VBP
cord-296347-fanlvxqs	15	3	on	on	IN
cord-296347-fanlvxqs	15	4	the	the	DT
cord-296347-fanlvxqs	15	5	implications	implication	NNS
cord-296347-fanlvxqs	15	6	of	of	IN
cord-296347-fanlvxqs	15	7	the	the	DT
cord-296347-fanlvxqs	15	8	three	three	CD
cord-296347-fanlvxqs	15	9	pathogen‐exploited	pathogen‐exploited	JJ
cord-296347-fanlvxqs	15	10	dislocation	dislocation	NN
cord-296347-fanlvxqs	15	11	pathways	pathway	NNS
cord-296347-fanlvxqs	15	12	to	to	IN
cord-296347-fanlvxqs	15	13	cellular	cellular	JJ
cord-296347-fanlvxqs	15	14	ER	ER	NNP
cord-296347-fanlvxqs	15	15	quality	quality	NN
cord-296347-fanlvxqs	15	16	control	control	NN
cord-296347-fanlvxqs	15	17	.	.	.
cord-296347-fanlvxqs	16	1	Moreover	moreover	RB
cord-296347-fanlvxqs	16	2	,	,	,
cord-296347-fanlvxqs	16	3	we	-PRON-	PRP
cord-296347-fanlvxqs	16	4	discuss	discuss	VBP
cord-296347-fanlvxqs	16	5	the	the	DT
cord-296347-fanlvxqs	16	6	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	16	7	(	(	-LRB-
cord-296347-fanlvxqs	16	8	Ub)‐proteasome	ub)‐proteasome	JJ
cord-296347-fanlvxqs	16	9	system	system	NN
cord-296347-fanlvxqs	16	10	and	and	CC
cord-296347-fanlvxqs	16	11	its	-PRON-	PRP$
cord-296347-fanlvxqs	16	12	position	position	NN
cord-296347-fanlvxqs	16	13	at	at	IN
cord-296347-fanlvxqs	16	14	the	the	DT
cord-296347-fanlvxqs	16	15	core	core	NN
cord-296347-fanlvxqs	16	16	of	of	IN
cord-296347-fanlvxqs	16	17	antigen	antigen	NN
cord-296347-fanlvxqs	16	18	presentation	presentation	NN
cord-296347-fanlvxqs	16	19	as	as	IN
cord-296347-fanlvxqs	16	20	proteolysis	proteolysis	NN
cord-296347-fanlvxqs	16	21	and	and	CC
cord-296347-fanlvxqs	16	22	intracellular	intracellular	JJ
cord-296347-fanlvxqs	16	23	trafficking	trafficking	NN
cord-296347-fanlvxqs	16	24	rely	rely	VBP
cord-296347-fanlvxqs	16	25	heavily	heavily	RB
cord-296347-fanlvxqs	16	26	on	on	IN
cord-296347-fanlvxqs	16	27	Ub‐dependent	ub‐dependent	NN
cord-296347-fanlvxqs	16	28	processes	process	NNS
cord-296347-fanlvxqs	16	29	.	.	.
cord-296347-fanlvxqs	17	1	We	-PRON-	PRP
cord-296347-fanlvxqs	17	2	add	add	VBP
cord-296347-fanlvxqs	17	3	a	a	DT
cord-296347-fanlvxqs	17	4	few	few	JJ
cord-296347-fanlvxqs	17	5	examples	example	NNS
cord-296347-fanlvxqs	17	6	of	of	IN
cord-296347-fanlvxqs	17	7	manipulation	manipulation	NN
cord-296347-fanlvxqs	17	8	of	of	IN
cord-296347-fanlvxqs	17	9	the	the	DT
cord-296347-fanlvxqs	17	10	Ub‐proteasome	Ub‐proteasome	VBN
cord-296347-fanlvxqs	17	11	system	system	NN
cord-296347-fanlvxqs	17	12	by	by	IN
cord-296347-fanlvxqs	17	13	pathogens	pathogen	NNS
cord-296347-fanlvxqs	17	14	in	in	IN
cord-296347-fanlvxqs	17	15	the	the	DT
cord-296347-fanlvxqs	17	16	context	context	NN
cord-296347-fanlvxqs	17	17	of	of	IN
cord-296347-fanlvxqs	17	18	the	the	DT
cord-296347-fanlvxqs	17	19	immune	immune	JJ
cord-296347-fanlvxqs	17	20	system	system	NN
cord-296347-fanlvxqs	17	21	and	and	CC
cord-296347-fanlvxqs	17	22	such	such	JJ
cord-296347-fanlvxqs	17	23	diverse	diverse	JJ
cord-296347-fanlvxqs	17	24	aspects	aspect	NNS
cord-296347-fanlvxqs	17	25	of	of	IN
cord-296347-fanlvxqs	17	26	the	the	DT
cord-296347-fanlvxqs	17	27	host	host	NN
cord-296347-fanlvxqs	17	28	–	–	:
cord-296347-fanlvxqs	17	29	pathogen	pathogen	NN
cord-296347-fanlvxqs	17	30	relationship	relationship	NN
cord-296347-fanlvxqs	17	31	as	as	IN
cord-296347-fanlvxqs	17	32	virus	virus	NN
cord-296347-fanlvxqs	17	33	budding	bud	VBG
cord-296347-fanlvxqs	17	34	,	,	,
cord-296347-fanlvxqs	17	35	bacterial	bacterial	JJ
cord-296347-fanlvxqs	17	36	chromosome	chromosome	NN
cord-296347-fanlvxqs	17	37	integration	integration	NN
cord-296347-fanlvxqs	17	38	,	,	,
cord-296347-fanlvxqs	17	39	and	and	CC
cord-296347-fanlvxqs	17	40	programmed	program	VBD
cord-296347-fanlvxqs	17	41	cell	cell	NN
cord-296347-fanlvxqs	17	42	death	death	NN
cord-296347-fanlvxqs	17	43	,	,	,
cord-296347-fanlvxqs	17	44	to	to	TO
cord-296347-fanlvxqs	17	45	name	name	VB
cord-296347-fanlvxqs	17	46	a	a	DT
cord-296347-fanlvxqs	17	47	few	few	JJ
cord-296347-fanlvxqs	17	48	.	.	.
cord-296347-fanlvxqs	18	1	Finally	finally	RB
cord-296347-fanlvxqs	18	2	,	,	,
cord-296347-fanlvxqs	18	3	we	-PRON-	PRP
cord-296347-fanlvxqs	18	4	speculate	speculate	VBP
cord-296347-fanlvxqs	18	5	on	on	IN
cord-296347-fanlvxqs	18	6	newly	newly	RB
cord-296347-fanlvxqs	18	7	found	find	VBN
cord-296347-fanlvxqs	18	8	pathogen‐encoded	pathogen‐encoded	JJ
cord-296347-fanlvxqs	18	9	deubiquitinating	deubiquitinating	NN
cord-296347-fanlvxqs	18	10	enzymes	enzyme	NNS
cord-296347-fanlvxqs	18	11	(	(	-LRB-
cord-296347-fanlvxqs	18	12	DUBs	dub	NNS
cord-296347-fanlvxqs	18	13	)	)	-RRB-
cord-296347-fanlvxqs	18	14	and	and	CC
cord-296347-fanlvxqs	18	15	their	-PRON-	PRP$
cord-296347-fanlvxqs	18	16	putative	putative	JJ
cord-296347-fanlvxqs	18	17	roles	role	NNS
cord-296347-fanlvxqs	18	18	in	in	IN
cord-296347-fanlvxqs	18	19	modulation	modulation	NN
cord-296347-fanlvxqs	18	20	of	of	IN
cord-296347-fanlvxqs	18	21	host	host	NN
cord-296347-fanlvxqs	18	22	–	–	:
cord-296347-fanlvxqs	18	23	pathogen	pathogen	NN
cord-296347-fanlvxqs	18	24	interactions	interaction	NNS
cord-296347-fanlvxqs	18	25	.	.	.
cord-296347-fanlvxqs	19	1	Relatively	relatively	RB
cord-296347-fanlvxqs	19	2	small	small	JJ
cord-296347-fanlvxqs	19	3	genomes	genome	NNS
cord-296347-fanlvxqs	19	4	and	and	CC
cord-296347-fanlvxqs	19	5	high	high	JJ
cord-296347-fanlvxqs	19	6	replication	replication	NN
cord-296347-fanlvxqs	19	7	rates	rate	NNS
cord-296347-fanlvxqs	19	8	allow	allow	VBP
cord-296347-fanlvxqs	19	9	viruses	virus	NNS
cord-296347-fanlvxqs	19	10	and	and	CC
cord-296347-fanlvxqs	19	11	bacteria	bacteria	NNS
cord-296347-fanlvxqs	19	12	to	to	TO
cord-296347-fanlvxqs	19	13	accumulate	accumulate	VB
cord-296347-fanlvxqs	19	14	mutations	mutation	NNS
cord-296347-fanlvxqs	19	15	.	.	.
cord-296347-fanlvxqs	20	1	This	this	DT
cord-296347-fanlvxqs	20	2	continuously	continuously	RB
cord-296347-fanlvxqs	20	3	presents	present	VBZ
cord-296347-fanlvxqs	20	4	the	the	DT
cord-296347-fanlvxqs	20	5	host	host	NN
cord-296347-fanlvxqs	20	6	immune	immune	JJ
cord-296347-fanlvxqs	20	7	system	system	NN
cord-296347-fanlvxqs	20	8	with	with	IN
cord-296347-fanlvxqs	20	9	new	new	JJ
cord-296347-fanlvxqs	20	10	challenges	challenge	NNS
cord-296347-fanlvxqs	20	11	.	.	.
cord-296347-fanlvxqs	21	1	On	on	IN
cord-296347-fanlvxqs	21	2	the	the	DT
cord-296347-fanlvxqs	21	3	other	other	JJ
cord-296347-fanlvxqs	21	4	side	side	NN
cord-296347-fanlvxqs	21	5	of	of	IN
cord-296347-fanlvxqs	21	6	the	the	DT
cord-296347-fanlvxqs	21	7	trenches	trench	NNS
cord-296347-fanlvxqs	21	8	,	,	,
cord-296347-fanlvxqs	21	9	an	an	DT
cord-296347-fanlvxqs	21	10	increasingly	increasingly	RB
cord-296347-fanlvxqs	21	11	welladjusted	welladjusted	JJ
cord-296347-fanlvxqs	21	12	host	host	NN
cord-296347-fanlvxqs	21	13	immune	immune	JJ
cord-296347-fanlvxqs	21	14	response	response	NN
cord-296347-fanlvxqs	21	15	,	,	,
cord-296347-fanlvxqs	21	16	shaped	shape	VBN
cord-296347-fanlvxqs	21	17	by	by	IN
cord-296347-fanlvxqs	21	18	coevolutionary	coevolutionary	JJ
cord-296347-fanlvxqs	21	19	history	history	NN
cord-296347-fanlvxqs	21	20	,	,	,
cord-296347-fanlvxqs	21	21	makes	make	VBZ
cord-296347-fanlvxqs	21	22	a	a	DT
cord-296347-fanlvxqs	21	23	pathogen	pathogen	NN
cord-296347-fanlvxqs	21	24	's	's	POS
cord-296347-fanlvxqs	21	25	life	life	NN
cord-296347-fanlvxqs	21	26	a	a	DT
cord-296347-fanlvxqs	21	27	rather	rather	RB
cord-296347-fanlvxqs	21	28	complicated	complicated	JJ
cord-296347-fanlvxqs	21	29	endeavor	endeavor	NN
cord-296347-fanlvxqs	21	30	.	.	.
cord-296347-fanlvxqs	22	1	It	-PRON-	PRP
cord-296347-fanlvxqs	22	2	is	be	VBZ
cord-296347-fanlvxqs	22	3	,	,	,
cord-296347-fanlvxqs	22	4	therefore	therefore	RB
cord-296347-fanlvxqs	22	5	,	,	,
cord-296347-fanlvxqs	22	6	no	no	DT
cord-296347-fanlvxqs	22	7	surprise	surprise	NN
cord-296347-fanlvxqs	22	8	that	that	IN
cord-296347-fanlvxqs	22	9	pathogens	pathogen	NNS
cord-296347-fanlvxqs	22	10	either	either	CC
cord-296347-fanlvxqs	22	11	escape	escape	VB
cord-296347-fanlvxqs	22	12	detection	detection	NN
cord-296347-fanlvxqs	22	13	or	or	CC
cord-296347-fanlvxqs	22	14	modulate	modulate	VB
cord-296347-fanlvxqs	22	15	the	the	DT
cord-296347-fanlvxqs	22	16	host	host	NN
cord-296347-fanlvxqs	22	17	immune	immune	JJ
cord-296347-fanlvxqs	22	18	response	response	NN
cord-296347-fanlvxqs	22	19	,	,	,
cord-296347-fanlvxqs	22	20	often	often	RB
cord-296347-fanlvxqs	22	21	by	by	IN
cord-296347-fanlvxqs	22	22	redirecting	redirect	VBG
cord-296347-fanlvxqs	22	23	normal	normal	JJ
cord-296347-fanlvxqs	22	24	cellular	cellular	JJ
cord-296347-fanlvxqs	22	25	pathways	pathway	NNS
cord-296347-fanlvxqs	22	26	to	to	IN
cord-296347-fanlvxqs	22	27	their	-PRON-	PRP$
cord-296347-fanlvxqs	22	28	advantage	advantage	NN
cord-296347-fanlvxqs	22	29	.	.	.
cord-296347-fanlvxqs	23	1	For	for	IN
cord-296347-fanlvxqs	23	2	the	the	DT
cord-296347-fanlvxqs	23	3	purpose	purpose	NN
cord-296347-fanlvxqs	23	4	of	of	IN
cord-296347-fanlvxqs	23	5	this	this	DT
cord-296347-fanlvxqs	23	6	chapter	chapter	NN
cord-296347-fanlvxqs	23	7	,	,	,
cord-296347-fanlvxqs	23	8	we	-PRON-	PRP
cord-296347-fanlvxqs	23	9	focus	focus	VBP
cord-296347-fanlvxqs	23	10	mainly	mainly	RB
cord-296347-fanlvxqs	23	11	on	on	IN
cord-296347-fanlvxqs	23	12	the	the	DT
cord-296347-fanlvxqs	23	13	manipulation	manipulation	NN
cord-296347-fanlvxqs	23	14	of	of	IN
cord-296347-fanlvxqs	23	15	the	the	DT
cord-296347-fanlvxqs	23	16	class	class	NN
cord-296347-fanlvxqs	23	17	I	i	NN
cord-296347-fanlvxqs	23	18	and	and	CC
cord-296347-fanlvxqs	23	19	class	class	NN
cord-296347-fanlvxqs	23	20	II	ii	NN
cord-296347-fanlvxqs	24	1	major	major	JJ
cord-296347-fanlvxqs	24	2	histocompatibility	histocompatibility	NN
cord-296347-fanlvxqs	24	3	complex	complex	NN
cord-296347-fanlvxqs	24	4	(	(	-LRB-
cord-296347-fanlvxqs	24	5	MHC	MHC	NNP
cord-296347-fanlvxqs	24	6	)	)	-RRB-
cord-296347-fanlvxqs	24	7	antigen	antigen	NN
cord-296347-fanlvxqs	24	8	presentation	presentation	NN
cord-296347-fanlvxqs	24	9	pathways	pathway	NNS
cord-296347-fanlvxqs	24	10	and	and	CC
cord-296347-fanlvxqs	24	11	the	the	DT
cord-296347-fanlvxqs	24	12	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	24	13	(	(	-LRB-
cord-296347-fanlvxqs	24	14	Ub)-proteasome	Ub)-proteasome	NNP
cord-296347-fanlvxqs	24	15	system	system	NN
cord-296347-fanlvxqs	24	16	by	by	IN
cord-296347-fanlvxqs	24	17	both	both	DT
cord-296347-fanlvxqs	24	18	viral	viral	JJ
cord-296347-fanlvxqs	24	19	and	and	CC
cord-296347-fanlvxqs	24	20	bacterial	bacterial	JJ
cord-296347-fanlvxqs	24	21	pathogens	pathogen	NNS
cord-296347-fanlvxqs	24	22	.	.	.
cord-296347-fanlvxqs	25	1	First	first	RB
cord-296347-fanlvxqs	25	2	,	,	,
cord-296347-fanlvxqs	25	3	we	-PRON-	PRP
cord-296347-fanlvxqs	25	4	describe	describe	VBP
cord-296347-fanlvxqs	25	5	the	the	DT
cord-296347-fanlvxqs	25	6	general	general	JJ
cord-296347-fanlvxqs	25	7	features	feature	NNS
cord-296347-fanlvxqs	25	8	of	of	IN
cord-296347-fanlvxqs	25	9	antigen	antigen	NN
cord-296347-fanlvxqs	25	10	presentation	presentation	NN
cord-296347-fanlvxqs	25	11	pathways	pathway	NNS
cord-296347-fanlvxqs	25	12	and	and	CC
cord-296347-fanlvxqs	25	13	the	the	DT
cord-296347-fanlvxqs	25	14	Ub	Ub	NNP
cord-296347-fanlvxqs	25	15	-	-	HYPH
cord-296347-fanlvxqs	25	16	proteasome	proteasome	VBN
cord-296347-fanlvxqs	25	17	system	system	NN
cord-296347-fanlvxqs	25	18	and	and	CC
cord-296347-fanlvxqs	25	19	then	then	RB
cord-296347-fanlvxqs	25	20	address	address	VB
cord-296347-fanlvxqs	25	21	how	how	WRB
cord-296347-fanlvxqs	25	22	they	-PRON-	PRP
cord-296347-fanlvxqs	25	23	are	be	VBP
cord-296347-fanlvxqs	25	24	manipulated	manipulate	VBN
cord-296347-fanlvxqs	25	25	by	by	IN
cord-296347-fanlvxqs	25	26	pathogens	pathogen	NNS
cord-296347-fanlvxqs	25	27	.	.	.
cord-296347-fanlvxqs	26	1	We	-PRON-	PRP
cord-296347-fanlvxqs	26	2	discuss	discuss	VBP
cord-296347-fanlvxqs	26	3	the	the	DT
cord-296347-fanlvxqs	26	4	many	many	JJ
cord-296347-fanlvxqs	26	5	human	human	JJ
cord-296347-fanlvxqs	26	6	cytomegalovirus	cytomegalovirus	NN
cord-296347-fanlvxqs	26	7	(	(	-LRB-
cord-296347-fanlvxqs	26	8	HCMV)-encoded	hcmv)-encoded	CD
cord-296347-fanlvxqs	26	9	immunomodulatory	immunomodulatory	JJ
cord-296347-fanlvxqs	26	10	genes	gene	NNS
cord-296347-fanlvxqs	26	11	that	that	WDT
cord-296347-fanlvxqs	26	12	interfere	interfere	VBP
cord-296347-fanlvxqs	26	13	with	with	IN
cord-296347-fanlvxqs	26	14	antigen	antigen	NN
cord-296347-fanlvxqs	26	15	presentation	presentation	NN
cord-296347-fanlvxqs	26	16	(	(	-LRB-
cord-296347-fanlvxqs	26	17	immunoevasins	immunoevasins	NNP
cord-296347-fanlvxqs	26	18	)	)	-RRB-
cord-296347-fanlvxqs	26	19	and	and	CC
cord-296347-fanlvxqs	26	20	focus	focus	VB
cord-296347-fanlvxqs	26	21	on	on	IN
cord-296347-fanlvxqs	26	22	the	the	DT
cord-296347-fanlvxqs	26	23	HCMV	HCMV	NNP
cord-296347-fanlvxqs	26	24	immunoevasins	immunoevasin	NNS
cord-296347-fanlvxqs	26	25	US2	US2	NNP
cord-296347-fanlvxqs	26	26	and	and	CC
cord-296347-fanlvxqs	26	27	US11	US11	NNP
cord-296347-fanlvxqs	26	28	,	,	,
cord-296347-fanlvxqs	26	29	which	which	WDT
cord-296347-fanlvxqs	26	30	induce	induce	VBP
cord-296347-fanlvxqs	26	31	the	the	DT
cord-296347-fanlvxqs	26	32	degradation	degradation	NN
cord-296347-fanlvxqs	26	33	of	of	IN
cord-296347-fanlvxqs	26	34	class	class	NN
cord-296347-fanlvxqs	27	1	I	-PRON-	PRP
cord-296347-fanlvxqs	27	2	MHC	MHC	NNP
cord-296347-fanlvxqs	27	3	heavy	heavy	JJ
cord-296347-fanlvxqs	27	4	chains	chain	NNS
cord-296347-fanlvxqs	27	5	by	by	IN
cord-296347-fanlvxqs	27	6	the	the	DT
cord-296347-fanlvxqs	27	7	proteasome	proteasome	NN
cord-296347-fanlvxqs	27	8	by	by	IN
cord-296347-fanlvxqs	27	9	catalyzing	catalyze	VBG
cord-296347-fanlvxqs	27	10	their	-PRON-	PRP$
cord-296347-fanlvxqs	27	11	export	export	NN
cord-296347-fanlvxqs	27	12	from	from	IN
cord-296347-fanlvxqs	27	13	the	the	DT
cord-296347-fanlvxqs	27	14	endoplasmic	endoplasmic	NN
cord-296347-fanlvxqs	27	15	reticulum	reticulum	NN
cord-296347-fanlvxqs	27	16	(	(	-LRB-
cord-296347-fanlvxqs	27	17	ER)-membrane	er)-membrane	CD
cord-296347-fanlvxqs	27	18	into	into	IN
cord-296347-fanlvxqs	27	19	the	the	DT
cord-296347-fanlvxqs	27	20	cytosol	cytosol	NN
cord-296347-fanlvxqs	27	21	,	,	,
cord-296347-fanlvxqs	27	22	a	a	DT
cord-296347-fanlvxqs	27	23	process	process	NN
cord-296347-fanlvxqs	27	24	termed	term	VBN
cord-296347-fanlvxqs	27	25	ER	ER	NNP
cord-296347-fanlvxqs	27	26	dislocation	dislocation	NN
cord-296347-fanlvxqs	27	27	.	.	.
cord-296347-fanlvxqs	28	1	US2-and	us2-and	CD
cord-296347-fanlvxqs	28	2	US11-mediated	us11-mediated	CD
cord-296347-fanlvxqs	28	3	subversion	subversion	NN
cord-296347-fanlvxqs	28	4	of	of	IN
cord-296347-fanlvxqs	28	5	ER	ER	NNP
cord-296347-fanlvxqs	28	6	dislocation	dislocation	NN
cord-296347-fanlvxqs	28	7	ensures	ensure	VBZ
cord-296347-fanlvxqs	28	8	proteasomal	proteasomal	JJ
cord-296347-fanlvxqs	28	9	degradation	degradation	NN
cord-296347-fanlvxqs	28	10	of	of	IN
cord-296347-fanlvxqs	28	11	class	class	NN
cord-296347-fanlvxqs	28	12	I	-PRON-	PRP
cord-296347-fanlvxqs	28	13	MHC	MHC	NNP
cord-296347-fanlvxqs	28	14	molecules	molecule	NNS
cord-296347-fanlvxqs	28	15	and	and	CC
cord-296347-fanlvxqs	28	16	presumably	presumably	RB
cord-296347-fanlvxqs	28	17	allows	allow	VBZ
cord-296347-fanlvxqs	28	18	HCMV	HCMV	NNP
cord-296347-fanlvxqs	28	19	to	to	TO
cord-296347-fanlvxqs	28	20	avoid	avoid	VB
cord-296347-fanlvxqs	28	21	recognition	recognition	NN
cord-296347-fanlvxqs	28	22	by	by	IN
cord-296347-fanlvxqs	28	23	cytotoxic	cytotoxic	JJ
cord-296347-fanlvxqs	28	24	T	t	NN
cord-296347-fanlvxqs	28	25	cells	cell	NNS
cord-296347-fanlvxqs	28	26	,	,	,
cord-296347-fanlvxqs	28	27	whilst	whilst	IN
cord-296347-fanlvxqs	28	28	providing	provide	VBG
cord-296347-fanlvxqs	28	29	insight	insight	NN
cord-296347-fanlvxqs	28	30	into	into	IN
cord-296347-fanlvxqs	28	31	general	general	JJ
cord-296347-fanlvxqs	28	32	aspects	aspect	NNS
cord-296347-fanlvxqs	28	33	of	of	IN
cord-296347-fanlvxqs	28	34	ER	ER	NNP
cord-296347-fanlvxqs	28	35	-	-	HYPH
cord-296347-fanlvxqs	28	36	associated	associate	VBN
cord-296347-fanlvxqs	28	37	degradation	degradation	NN
cord-296347-fanlvxqs	28	38	(	(	-LRB-
cord-296347-fanlvxqs	28	39	ERAD	ERAD	NNP
cord-296347-fanlvxqs	28	40	)	)	-RRB-
cord-296347-fanlvxqs	28	41	which	which	WDT
cord-296347-fanlvxqs	28	42	is	be	VBZ
cord-296347-fanlvxqs	28	43	used	use	VBN
cord-296347-fanlvxqs	28	44	by	by	IN
cord-296347-fanlvxqs	28	45	eukaryotic	eukaryotic	JJ
cord-296347-fanlvxqs	28	46	cells	cell	NNS
cord-296347-fanlvxqs	28	47	to	to	TO
cord-296347-fanlvxqs	28	48	purge	purge	VB
cord-296347-fanlvxqs	28	49	their	-PRON-	PRP$
cord-296347-fanlvxqs	28	50	ER	er	NN
cord-296347-fanlvxqs	28	51	of	of	IN
cord-296347-fanlvxqs	28	52	defective	defective	JJ
cord-296347-fanlvxqs	28	53	proteins	protein	NNS
cord-296347-fanlvxqs	28	54	.	.	.
cord-296347-fanlvxqs	29	1	We	-PRON-	PRP
cord-296347-fanlvxqs	29	2	discuss	discuss	VBP
cord-296347-fanlvxqs	29	3	the	the	DT
cord-296347-fanlvxqs	29	4	similarities	similarity	NNS
cord-296347-fanlvxqs	29	5	and	and	CC
cord-296347-fanlvxqs	29	6	differences	difference	NNS
cord-296347-fanlvxqs	29	7	between	between	IN
cord-296347-fanlvxqs	29	8	the	the	DT
cord-296347-fanlvxqs	29	9	distinct	distinct	JJ
cord-296347-fanlvxqs	29	10	pathways	pathway	NNS
cord-296347-fanlvxqs	29	11	coopted	coopte	VBN
cord-296347-fanlvxqs	29	12	by	by	IN
cord-296347-fanlvxqs	29	13	US2	US2	NNP
cord-296347-fanlvxqs	29	14	and	and	CC
cord-296347-fanlvxqs	29	15	US11	US11	NNP
cord-296347-fanlvxqs	29	16	for	for	IN
cord-296347-fanlvxqs	29	17	dislocation	dislocation	NN
cord-296347-fanlvxqs	29	18	and	and	CC
cord-296347-fanlvxqs	29	19	degradation	degradation	NN
cord-296347-fanlvxqs	29	20	of	of	IN
cord-296347-fanlvxqs	29	21	human	human	JJ
cord-296347-fanlvxqs	29	22	class	class	NN
cord-296347-fanlvxqs	29	23	I	-PRON-	PRP
cord-296347-fanlvxqs	29	24	MHC	MHC	NNP
cord-296347-fanlvxqs	29	25	molecules	molecule	NNS
cord-296347-fanlvxqs	29	26	and	and	CC
cord-296347-fanlvxqs	29	27	also	also	RB
cord-296347-fanlvxqs	29	28	a	a	DT
cord-296347-fanlvxqs	29	29	putatively	putatively	RB
cord-296347-fanlvxqs	29	30	distinct	distinct	JJ
cord-296347-fanlvxqs	29	31	pathway	pathway	NN
cord-296347-fanlvxqs	29	32	utilized	utilize	VBN
cord-296347-fanlvxqs	29	33	by	by	IN
cord-296347-fanlvxqs	29	34	the	the	DT
cord-296347-fanlvxqs	29	35	murine	murine	JJ
cord-296347-fanlvxqs	29	36	herpes	herpes	NNP
cord-296347-fanlvxqs	29	37	virus	virus	NN
cord-296347-fanlvxqs	29	38	(	(	-LRB-
cord-296347-fanlvxqs	29	39	MHV)-68	MHV)-68	NNP
cord-296347-fanlvxqs	29	40	mK3	mK3	NNP
cord-296347-fanlvxqs	29	41	immunoevasin	immunoevasin	NNP
cord-296347-fanlvxqs	29	42	for	for	IN
cord-296347-fanlvxqs	29	43	ER	ER	NNP
cord-296347-fanlvxqs	29	44	dislocation	dislocation	NN
cord-296347-fanlvxqs	29	45	of	of	IN
cord-296347-fanlvxqs	29	46	murine	murine	JJ
cord-296347-fanlvxqs	29	47	class	class	NN
cord-296347-fanlvxqs	30	1	I	-PRON-	PRP
cord-296347-fanlvxqs	30	2	MHC	MHC	NNP
cord-296347-fanlvxqs	30	3	.	.	.
cord-296347-fanlvxqs	31	1	We	-PRON-	PRP
cord-296347-fanlvxqs	31	2	speculate	speculate	VBP
cord-296347-fanlvxqs	31	3	on	on	IN
cord-296347-fanlvxqs	31	4	the	the	DT
cord-296347-fanlvxqs	31	5	implications	implication	NNS
cord-296347-fanlvxqs	31	6	of	of	IN
cord-296347-fanlvxqs	31	7	the	the	DT
cord-296347-fanlvxqs	31	8	three	three	CD
cord-296347-fanlvxqs	31	9	pathogen	pathogen	NN
cord-296347-fanlvxqs	31	10	-	-	HYPH
cord-296347-fanlvxqs	31	11	exploited	exploit	VBN
cord-296347-fanlvxqs	31	12	dislocation	dislocation	NN
cord-296347-fanlvxqs	31	13	pathways	pathway	NNS
cord-296347-fanlvxqs	31	14	to	to	IN
cord-296347-fanlvxqs	31	15	cellular	cellular	JJ
cord-296347-fanlvxqs	31	16	ER	ER	NNP
cord-296347-fanlvxqs	31	17	quality	quality	NN
cord-296347-fanlvxqs	31	18	control	control	NN
cord-296347-fanlvxqs	31	19	.	.	.
cord-296347-fanlvxqs	32	1	Moreover	moreover	RB
cord-296347-fanlvxqs	32	2	,	,	,
cord-296347-fanlvxqs	32	3	we	-PRON-	PRP
cord-296347-fanlvxqs	32	4	discuss	discuss	VBP
cord-296347-fanlvxqs	32	5	the	the	DT
cord-296347-fanlvxqs	32	6	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	32	7	(	(	-LRB-
cord-296347-fanlvxqs	32	8	Ub)-proteasome	Ub)-proteasome	NNP
cord-296347-fanlvxqs	32	9	system	system	NN
cord-296347-fanlvxqs	32	10	and	and	CC
cord-296347-fanlvxqs	32	11	its	-PRON-	PRP$
cord-296347-fanlvxqs	32	12	position	position	NN
cord-296347-fanlvxqs	32	13	at	at	IN
cord-296347-fanlvxqs	32	14	the	the	DT
cord-296347-fanlvxqs	32	15	core	core	NN
cord-296347-fanlvxqs	32	16	of	of	IN
cord-296347-fanlvxqs	32	17	antigen	antigen	NN
cord-296347-fanlvxqs	32	18	presentation	presentation	NN
cord-296347-fanlvxqs	32	19	as	as	IN
cord-296347-fanlvxqs	32	20	proteolysis	proteolysis	NN
cord-296347-fanlvxqs	32	21	and	and	CC
cord-296347-fanlvxqs	32	22	intracellular	intracellular	JJ
cord-296347-fanlvxqs	32	23	trafficking	trafficking	NN
cord-296347-fanlvxqs	32	24	rely	rely	VBP
cord-296347-fanlvxqs	32	25	heavily	heavily	RB
cord-296347-fanlvxqs	32	26	on	on	IN
cord-296347-fanlvxqs	32	27	Ub	ub	JJ
cord-296347-fanlvxqs	32	28	-	-	HYPH
cord-296347-fanlvxqs	32	29	dependent	dependent	JJ
cord-296347-fanlvxqs	32	30	processes	process	NNS
cord-296347-fanlvxqs	32	31	.	.	.
cord-296347-fanlvxqs	33	1	We	-PRON-	PRP
cord-296347-fanlvxqs	33	2	add	add	VBP
cord-296347-fanlvxqs	33	3	a	a	DT
cord-296347-fanlvxqs	33	4	few	few	JJ
cord-296347-fanlvxqs	33	5	examples	example	NNS
cord-296347-fanlvxqs	33	6	of	of	IN
cord-296347-fanlvxqs	33	7	manipulation	manipulation	NN
cord-296347-fanlvxqs	33	8	of	of	IN
cord-296347-fanlvxqs	33	9	the	the	DT
cord-296347-fanlvxqs	33	10	Ub	Ub	NNP
cord-296347-fanlvxqs	33	11	-	-	HYPH
cord-296347-fanlvxqs	33	12	proteasome	proteasome	VBN
cord-296347-fanlvxqs	33	13	system	system	NN
cord-296347-fanlvxqs	33	14	by	by	IN
cord-296347-fanlvxqs	33	15	pathogens	pathogen	NNS
cord-296347-fanlvxqs	33	16	in	in	IN
cord-296347-fanlvxqs	33	17	the	the	DT
cord-296347-fanlvxqs	33	18	context	context	NN
cord-296347-fanlvxqs	33	19	of	of	IN
cord-296347-fanlvxqs	33	20	the	the	DT
cord-296347-fanlvxqs	33	21	immune	immune	JJ
cord-296347-fanlvxqs	33	22	system	system	NN
cord-296347-fanlvxqs	33	23	and	and	CC
cord-296347-fanlvxqs	33	24	such	such	JJ
cord-296347-fanlvxqs	33	25	diverse	diverse	JJ
cord-296347-fanlvxqs	33	26	aspects	aspect	NNS
cord-296347-fanlvxqs	33	27	of	of	IN
cord-296347-fanlvxqs	33	28	the	the	DT
cord-296347-fanlvxqs	33	29	host	host	NN
cord-296347-fanlvxqs	33	30	-	-	HYPH
cord-296347-fanlvxqs	33	31	pathogen	pathogen	NN
cord-296347-fanlvxqs	33	32	relationship	relationship	NN
cord-296347-fanlvxqs	33	33	as	as	IN
cord-296347-fanlvxqs	33	34	virus	virus	NN
cord-296347-fanlvxqs	33	35	budding	bud	VBG
cord-296347-fanlvxqs	33	36	,	,	,
cord-296347-fanlvxqs	33	37	bacterial	bacterial	JJ
cord-296347-fanlvxqs	33	38	chromosome	chromosome	NN
cord-296347-fanlvxqs	33	39	integration	integration	NN
cord-296347-fanlvxqs	33	40	,	,	,
cord-296347-fanlvxqs	33	41	and	and	CC
cord-296347-fanlvxqs	33	42	programmed	program	VBD
cord-296347-fanlvxqs	33	43	cell	cell	NN
cord-296347-fanlvxqs	33	44	death	death	NN
cord-296347-fanlvxqs	33	45	,	,	,
cord-296347-fanlvxqs	33	46	to	to	TO
cord-296347-fanlvxqs	33	47	name	name	VB
cord-296347-fanlvxqs	33	48	a	a	DT
cord-296347-fanlvxqs	33	49	few	few	JJ
cord-296347-fanlvxqs	33	50	.	.	.
cord-296347-fanlvxqs	34	1	Finally	finally	RB
cord-296347-fanlvxqs	34	2	,	,	,
cord-296347-fanlvxqs	34	3	we	-PRON-	PRP
cord-296347-fanlvxqs	34	4	speculate	speculate	VBP
cord-296347-fanlvxqs	34	5	on	on	IN
cord-296347-fanlvxqs	34	6	newly	newly	RB
cord-296347-fanlvxqs	34	7	found	find	VBN
cord-296347-fanlvxqs	34	8	pathogen	pathogen	NN
cord-296347-fanlvxqs	34	9	-	-	HYPH
cord-296347-fanlvxqs	34	10	encoded	encode	VBN
cord-296347-fanlvxqs	34	11	deubiquitinating	deubiquitinating	NN
cord-296347-fanlvxqs	34	12	enzymes	enzyme	NNS
cord-296347-fanlvxqs	34	13	(	(	-LRB-
cord-296347-fanlvxqs	34	14	DUBs	dub	NNS
cord-296347-fanlvxqs	34	15	)	)	-RRB-
cord-296347-fanlvxqs	34	16	and	and	CC
cord-296347-fanlvxqs	34	17	their	-PRON-	PRP$
cord-296347-fanlvxqs	34	18	putative	putative	JJ
cord-296347-fanlvxqs	34	19	roles	role	NNS
cord-296347-fanlvxqs	34	20	in	in	IN
cord-296347-fanlvxqs	34	21	modulation	modulation	NN
cord-296347-fanlvxqs	34	22	of	of	IN
cord-296347-fanlvxqs	34	23	host	host	NN
cord-296347-fanlvxqs	34	24	-	-	HYPH
cord-296347-fanlvxqs	34	25	pathogen	pathogen	NN
cord-296347-fanlvxqs	34	26	interactions	interaction	NNS
cord-296347-fanlvxqs	34	27	.	.	.
cord-296347-fanlvxqs	35	1	The	the	DT
cord-296347-fanlvxqs	35	2	vertebrate	vertebrate	JJ
cord-296347-fanlvxqs	35	3	immune	immune	JJ
cord-296347-fanlvxqs	35	4	system	system	NN
cord-296347-fanlvxqs	35	5	is	be	VBZ
cord-296347-fanlvxqs	35	6	equipped	equip	VBN
cord-296347-fanlvxqs	35	7	to	to	TO
cord-296347-fanlvxqs	35	8	deal	deal	VB
cord-296347-fanlvxqs	35	9	with	with	IN
cord-296347-fanlvxqs	35	10	invading	invade	VBG
cord-296347-fanlvxqs	35	11	pathogens	pathogen	NNS
cord-296347-fanlvxqs	35	12	,	,	,
cord-296347-fanlvxqs	35	13	whether	whether	IN
cord-296347-fanlvxqs	35	14	by	by	IN
cord-296347-fanlvxqs	35	15	means	mean	NNS
cord-296347-fanlvxqs	35	16	of	of	IN
cord-296347-fanlvxqs	35	17	mechanical	mechanical	JJ
cord-296347-fanlvxqs	35	18	barriers	barrier	NNS
cord-296347-fanlvxqs	35	19	such	such	JJ
cord-296347-fanlvxqs	35	20	as	as	IN
cord-296347-fanlvxqs	35	21	the	the	DT
cord-296347-fanlvxqs	35	22	skin	skin	NN
cord-296347-fanlvxqs	35	23	and	and	CC
cord-296347-fanlvxqs	35	24	other	other	JJ
cord-296347-fanlvxqs	35	25	epithelial	epithelial	JJ
cord-296347-fanlvxqs	35	26	surfaces	surface	NNS
cord-296347-fanlvxqs	35	27	or	or	CC
cord-296347-fanlvxqs	35	28	by	by	IN
cord-296347-fanlvxqs	35	29	means	mean	NNS
cord-296347-fanlvxqs	35	30	of	of	IN
cord-296347-fanlvxqs	35	31	innate	innate	JJ
cord-296347-fanlvxqs	35	32	immunity	immunity	NN
cord-296347-fanlvxqs	35	33	.	.	.
cord-296347-fanlvxqs	36	1	Innate	innate	JJ
cord-296347-fanlvxqs	36	2	immunity	immunity	NN
cord-296347-fanlvxqs	36	3	comprises	comprise	VBZ
cord-296347-fanlvxqs	36	4	the	the	DT
cord-296347-fanlvxqs	36	5	phagocytic	phagocytic	JJ
cord-296347-fanlvxqs	36	6	and	and	CC
cord-296347-fanlvxqs	36	7	inflammatory	inflammatory	JJ
cord-296347-fanlvxqs	36	8	systems	system	NNS
cord-296347-fanlvxqs	36	9	,	,	,
cord-296347-fanlvxqs	36	10	with	with	IN
cord-296347-fanlvxqs	36	11	phagocytes	phagocyte	NNS
cord-296347-fanlvxqs	36	12	like	like	IN
cord-296347-fanlvxqs	36	13	macrophages	macrophage	NNS
cord-296347-fanlvxqs	36	14	and	and	CC
cord-296347-fanlvxqs	36	15	neutrophils	neutrophil	NNS
cord-296347-fanlvxqs	36	16	,	,	,
cord-296347-fanlvxqs	36	17	dendritic	dendritic	JJ
cord-296347-fanlvxqs	36	18	cells	cell	NNS
cord-296347-fanlvxqs	36	19	(	(	-LRB-
cord-296347-fanlvxqs	36	20	DCs	DCs	NNP
cord-296347-fanlvxqs	36	21	)	)	-RRB-
cord-296347-fanlvxqs	36	22	,	,	,
cord-296347-fanlvxqs	36	23	and	and	CC
cord-296347-fanlvxqs	36	24	natural	natural	JJ
cord-296347-fanlvxqs	36	25	killer	killer	NN
cord-296347-fanlvxqs	36	26	(	(	-LRB-
cord-296347-fanlvxqs	36	27	NK	NK	NNP
cord-296347-fanlvxqs	36	28	)	)	-RRB-
cord-296347-fanlvxqs	36	29	cells	cell	NNS
cord-296347-fanlvxqs	36	30	,	,	,
cord-296347-fanlvxqs	36	31	as	as	RB
cord-296347-fanlvxqs	36	32	well	well	RB
cord-296347-fanlvxqs	36	33	as	as	IN
cord-296347-fanlvxqs	36	34	soluble	soluble	JJ
cord-296347-fanlvxqs	36	35	mediators	mediator	NNS
cord-296347-fanlvxqs	36	36	such	such	JJ
cord-296347-fanlvxqs	36	37	as	as	IN
cord-296347-fanlvxqs	36	38	cytokines	cytokine	NNS
cord-296347-fanlvxqs	36	39	and	and	CC
cord-296347-fanlvxqs	36	40	complement	complement	NN
cord-296347-fanlvxqs	36	41	.	.	.
cord-296347-fanlvxqs	37	1	Phagocytes	phagocyte	NNS
cord-296347-fanlvxqs	37	2	are	be	VBP
cord-296347-fanlvxqs	37	3	the	the	DT
cord-296347-fanlvxqs	37	4	immune	immune	JJ
cord-296347-fanlvxqs	37	5	system	system	NN
cord-296347-fanlvxqs	37	6	's	's	POS
cord-296347-fanlvxqs	37	7	first	first	JJ
cord-296347-fanlvxqs	37	8	line	line	NN
cord-296347-fanlvxqs	37	9	of	of	IN
cord-296347-fanlvxqs	37	10	defense	defense	NN
cord-296347-fanlvxqs	37	11	:	:	:
cord-296347-fanlvxqs	37	12	they	-PRON-	PRP
cord-296347-fanlvxqs	37	13	recognize	recognize	VBP
cord-296347-fanlvxqs	37	14	,	,	,
cord-296347-fanlvxqs	37	15	engulf	engulf	VBP
cord-296347-fanlvxqs	37	16	,	,	,
cord-296347-fanlvxqs	37	17	and	and	CC
cord-296347-fanlvxqs	37	18	clear	clear	VB
cord-296347-fanlvxqs	37	19	the	the	DT
cord-296347-fanlvxqs	37	20	pathogen	pathogen	NN
cord-296347-fanlvxqs	37	21	and	and	CC
cord-296347-fanlvxqs	37	22	are	be	VBP
cord-296347-fanlvxqs	37	23	the	the	DT
cord-296347-fanlvxqs	37	24	main	main	JJ
cord-296347-fanlvxqs	37	25	cellular	cellular	JJ
cord-296347-fanlvxqs	37	26	component	component	NN
cord-296347-fanlvxqs	37	27	of	of	IN
cord-296347-fanlvxqs	37	28	the	the	DT
cord-296347-fanlvxqs	37	29	innate	innate	JJ
cord-296347-fanlvxqs	37	30	antibacterial	antibacterial	JJ
cord-296347-fanlvxqs	37	31	response	response	NN
cord-296347-fanlvxqs	37	32	.	.	.
cord-296347-fanlvxqs	38	1	NK	NK	NNP
cord-296347-fanlvxqs	38	2	cells	cell	NNS
cord-296347-fanlvxqs	38	3	can	can	MD
cord-296347-fanlvxqs	38	4	directly	directly	RB
cord-296347-fanlvxqs	38	5	recognize	recognize	VB
cord-296347-fanlvxqs	38	6	and	and	CC
cord-296347-fanlvxqs	38	7	kill	kill	VB
cord-296347-fanlvxqs	38	8	pathogen	pathogen	NN
cord-296347-fanlvxqs	38	9	-	-	HYPH
cord-296347-fanlvxqs	38	10	infected	infect	VBN
cord-296347-fanlvxqs	38	11	cells	cell	NNS
cord-296347-fanlvxqs	38	12	that	that	WDT
cord-296347-fanlvxqs	38	13	fail	fail	VBP
cord-296347-fanlvxqs	38	14	to	to	TO
cord-296347-fanlvxqs	38	15	express	express	VB
cord-296347-fanlvxqs	38	16	MHC	MHC	NNP
cord-296347-fanlvxqs	38	17	molecules	molecule	NNS
cord-296347-fanlvxqs	38	18	and	and	CC
cord-296347-fanlvxqs	38	19	secrete	secrete	JJ
cord-296347-fanlvxqs	38	20	cytokines	cytokine	NNS
cord-296347-fanlvxqs	38	21	that	that	WDT
cord-296347-fanlvxqs	38	22	affect	affect	VBP
cord-296347-fanlvxqs	38	23	the	the	DT
cord-296347-fanlvxqs	38	24	immune	immune	JJ
cord-296347-fanlvxqs	38	25	response	response	NN
cord-296347-fanlvxqs	38	26	.	.	.
cord-296347-fanlvxqs	39	1	NK	NK	NNP
cord-296347-fanlvxqs	39	2	cells	cell	NNS
cord-296347-fanlvxqs	39	3	are	be	VBP
cord-296347-fanlvxqs	39	4	the	the	DT
cord-296347-fanlvxqs	39	5	main	main	JJ
cord-296347-fanlvxqs	39	6	cellular	cellular	JJ
cord-296347-fanlvxqs	39	7	effectors	effector	NNS
cord-296347-fanlvxqs	39	8	of	of	IN
cord-296347-fanlvxqs	39	9	the	the	DT
cord-296347-fanlvxqs	39	10	innate	innate	JJ
cord-296347-fanlvxqs	39	11	response	response	NN
cord-296347-fanlvxqs	39	12	against	against	IN
cord-296347-fanlvxqs	39	13	viruses	virus	NNS
cord-296347-fanlvxqs	39	14	.	.	.
cord-296347-fanlvxqs	40	1	The	the	DT
cord-296347-fanlvxqs	40	2	complement	complement	NN
cord-296347-fanlvxqs	40	3	system	system	NN
cord-296347-fanlvxqs	40	4	can	can	MD
cord-296347-fanlvxqs	40	5	lyse	lyse	VB
cord-296347-fanlvxqs	40	6	infected	infected	JJ
cord-296347-fanlvxqs	40	7	cells	cell	NNS
cord-296347-fanlvxqs	40	8	or	or	CC
cord-296347-fanlvxqs	40	9	simply	simply	RB
cord-296347-fanlvxqs	40	10	coat	coat	VB
cord-296347-fanlvxqs	40	11	the	the	DT
cord-296347-fanlvxqs	40	12	surface	surface	NN
cord-296347-fanlvxqs	40	13	of	of	IN
cord-296347-fanlvxqs	40	14	the	the	DT
cord-296347-fanlvxqs	40	15	pathogen	pathogen	NN
cord-296347-fanlvxqs	40	16	or	or	CC
cord-296347-fanlvxqs	40	17	pathogen	pathogen	NN
cord-296347-fanlvxqs	40	18	-	-	HYPH
cord-296347-fanlvxqs	40	19	derived	derive	VBN
cord-296347-fanlvxqs	40	20	material	material	NN
cord-296347-fanlvxqs	40	21	,	,	,
cord-296347-fanlvxqs	40	22	resulting	result	VBG
cord-296347-fanlvxqs	40	23	in	in	IN
cord-296347-fanlvxqs	40	24	its	-PRON-	PRP$
cord-296347-fanlvxqs	40	25	neutralization	neutralization	NN
cord-296347-fanlvxqs	40	26	and	and	CC
cord-296347-fanlvxqs	40	27	opsonization	opsonization	NN
cord-296347-fanlvxqs	40	28	.	.	.
cord-296347-fanlvxqs	41	1	To	to	TO
cord-296347-fanlvxqs	41	2	counteract	counteract	VB
cord-296347-fanlvxqs	41	3	pathogen	pathogen	NN
cord-296347-fanlvxqs	41	4	infection	infection	NN
cord-296347-fanlvxqs	41	5	,	,	,
cord-296347-fanlvxqs	41	6	host	host	NN
cord-296347-fanlvxqs	41	7	cells	cell	NNS
cord-296347-fanlvxqs	41	8	also	also	RB
cord-296347-fanlvxqs	41	9	have	have	VBP
cord-296347-fanlvxqs	41	10	extracellular	extracellular	JJ
cord-296347-fanlvxqs	41	11	and	and	CC
cord-296347-fanlvxqs	41	12	intracellular	intracellular	JJ
cord-296347-fanlvxqs	41	13	pathogen	pathogen	NN
cord-296347-fanlvxqs	41	14	recognition	recognition	NN
cord-296347-fanlvxqs	41	15	receptors	receptor	NNS
cord-296347-fanlvxqs	41	16	to	to	TO
cord-296347-fanlvxqs	41	17	alert	alert	VB
cord-296347-fanlvxqs	41	18	the	the	DT
cord-296347-fanlvxqs	41	19	immune	immune	JJ
cord-296347-fanlvxqs	41	20	system	system	NN
cord-296347-fanlvxqs	41	21	,	,	,
cord-296347-fanlvxqs	41	22	such	such	JJ
cord-296347-fanlvxqs	41	23	as	as	IN
cord-296347-fanlvxqs	41	24	toll	toll	NN
cord-296347-fanlvxqs	41	25	-	-	HYPH
cord-296347-fanlvxqs	41	26	like	like	JJ
cord-296347-fanlvxqs	41	27	receptors	receptor	NNS
cord-296347-fanlvxqs	41	28	(	(	-LRB-
cord-296347-fanlvxqs	41	29	TLRs	TLRs	NNP
cord-296347-fanlvxqs	41	30	)	)	-RRB-
cord-296347-fanlvxqs	41	31	at	at	IN
cord-296347-fanlvxqs	41	32	the	the	DT
cord-296347-fanlvxqs	41	33	cell	cell	NN
cord-296347-fanlvxqs	41	34	surface	surface	NN
cord-296347-fanlvxqs	41	35	,	,	,
cord-296347-fanlvxqs	41	36	and	and	CC
cord-296347-fanlvxqs	41	37	protein	protein	NN
cord-296347-fanlvxqs	41	38	kinase	kinase	NN
cord-296347-fanlvxqs	41	39	R	r	NN
cord-296347-fanlvxqs	41	40	(	(	-LRB-
cord-296347-fanlvxqs	41	41	PKR	PKR	NNP
cord-296347-fanlvxqs	41	42	)	)	-RRB-
cord-296347-fanlvxqs	41	43	and	and	CC
cord-296347-fanlvxqs	41	44	nucleotidebinding	nucleotidebinde	VBG
cord-296347-fanlvxqs	41	45	oligomerization	oligomerization	NN
cord-296347-fanlvxqs	41	46	domain	domain	NN
cord-296347-fanlvxqs	41	47	(	(	-LRB-
cord-296347-fanlvxqs	41	48	NOD	nod	NN
cord-296347-fanlvxqs	41	49	)	)	-RRB-
cord-296347-fanlvxqs	41	50	proteins	protein	NNS
cord-296347-fanlvxqs	41	51	in	in	IN
cord-296347-fanlvxqs	41	52	the	the	DT
cord-296347-fanlvxqs	41	53	cytosol	cytosol	NN
cord-296347-fanlvxqs	42	1	(	(	-LRB-
cord-296347-fanlvxqs	42	2	Akira	Akira	NNP
cord-296347-fanlvxqs	42	3	et	et	NNP
cord-296347-fanlvxqs	42	4	al	al	NNP
cord-296347-fanlvxqs	42	5	.	.	NNP
cord-296347-fanlvxqs	42	6	,	,	,
cord-296347-fanlvxqs	42	7	2006	2006	CD
cord-296347-fanlvxqs	43	1	;	;	:
cord-296347-fanlvxqs	43	2	Inohara	Inohara	NNP
cord-296347-fanlvxqs	43	3	et	et	NNP
cord-296347-fanlvxqs	43	4	al	al	NNP
cord-296347-fanlvxqs	43	5	.	.	NNP
cord-296347-fanlvxqs	43	6	,	,	,
cord-296347-fanlvxqs	43	7	2005	2005	CD
cord-296347-fanlvxqs	43	8	)	)	-RRB-
cord-296347-fanlvxqs	43	9	that	that	WDT
cord-296347-fanlvxqs	43	10	can	can	MD
cord-296347-fanlvxqs	43	11	detect	detect	VB
cord-296347-fanlvxqs	43	12	pathogen	pathogen	NN
cord-296347-fanlvxqs	43	13	-	-	HYPH
cord-296347-fanlvxqs	43	14	associated	associate	VBN
cord-296347-fanlvxqs	43	15	molecular	molecular	JJ
cord-296347-fanlvxqs	43	16	patterns	pattern	NNS
cord-296347-fanlvxqs	43	17	(	(	-LRB-
cord-296347-fanlvxqs	43	18	PAMPs	pamp	NNS
cord-296347-fanlvxqs	43	19	)	)	-RRB-
cord-296347-fanlvxqs	43	20	such	such	JJ
cord-296347-fanlvxqs	43	21	as	as	IN
cord-296347-fanlvxqs	43	22	bacterial	bacterial	JJ
cord-296347-fanlvxqs	43	23	peptidoglycan	peptidoglycan	NN
cord-296347-fanlvxqs	43	24	or	or	CC
cord-296347-fanlvxqs	43	25	viral	viral	JJ
cord-296347-fanlvxqs	43	26	dsRNA	dsrna	NN
cord-296347-fanlvxqs	43	27	.	.	.
cord-296347-fanlvxqs	44	1	These	these	DT
cord-296347-fanlvxqs	44	2	'	'	``
cord-296347-fanlvxqs	44	3	'	'	``
cord-296347-fanlvxqs	44	4	danger	danger	NN
cord-296347-fanlvxqs	44	5	'	'	''
cord-296347-fanlvxqs	44	6	'	'	''
cord-296347-fanlvxqs	44	7	signals	signal	NNS
cord-296347-fanlvxqs	44	8	initiate	initiate	VBP
cord-296347-fanlvxqs	44	9	the	the	DT
cord-296347-fanlvxqs	44	10	synthesis	synthesis	NN
cord-296347-fanlvxqs	44	11	of	of	IN
cord-296347-fanlvxqs	44	12	cytokines	cytokine	NNS
cord-296347-fanlvxqs	44	13	like	like	IN
cord-296347-fanlvxqs	44	14	interferons	interferon	NNS
cord-296347-fanlvxqs	44	15	to	to	TO
cord-296347-fanlvxqs	44	16	induce	induce	VB
cord-296347-fanlvxqs	44	17	inflammation	inflammation	NN
cord-296347-fanlvxqs	44	18	,	,	,
cord-296347-fanlvxqs	44	19	a	a	DT
cord-296347-fanlvxqs	44	20	crucial	crucial	JJ
cord-296347-fanlvxqs	44	21	component	component	NN
cord-296347-fanlvxqs	44	22	of	of	IN
cord-296347-fanlvxqs	44	23	the	the	DT
cord-296347-fanlvxqs	44	24	innate	innate	JJ
cord-296347-fanlvxqs	44	25	defense	defense	NN
cord-296347-fanlvxqs	44	26	against	against	IN
cord-296347-fanlvxqs	44	27	pathogens	pathogen	NNS
cord-296347-fanlvxqs	44	28	.	.	.
cord-296347-fanlvxqs	45	1	Because	because	IN
cord-296347-fanlvxqs	45	2	innate	innate	JJ
cord-296347-fanlvxqs	45	3	immunity	immunity	NN
cord-296347-fanlvxqs	45	4	is	be	VBZ
cord-296347-fanlvxqs	45	5	not	not	RB
cord-296347-fanlvxqs	45	6	always	always	RB
cord-296347-fanlvxqs	45	7	successful	successful	JJ
cord-296347-fanlvxqs	45	8	at	at	IN
cord-296347-fanlvxqs	45	9	recognizing	recognize	VBG
cord-296347-fanlvxqs	45	10	or	or	CC
cord-296347-fanlvxqs	45	11	eliminating	eliminate	VBG
cord-296347-fanlvxqs	45	12	the	the	DT
cord-296347-fanlvxqs	45	13	infectious	infectious	JJ
cord-296347-fanlvxqs	45	14	agents	agent	NNS
cord-296347-fanlvxqs	45	15	,	,	,
cord-296347-fanlvxqs	45	16	a	a	DT
cord-296347-fanlvxqs	45	17	more	more	RBR
cord-296347-fanlvxqs	45	18	sophisticated	sophisticated	JJ
cord-296347-fanlvxqs	45	19	line	line	NN
cord-296347-fanlvxqs	45	20	of	of	IN
cord-296347-fanlvxqs	45	21	defense	defense	NN
cord-296347-fanlvxqs	45	22	,	,	,
cord-296347-fanlvxqs	45	23	adaptive	adaptive	JJ
cord-296347-fanlvxqs	45	24	immunity	immunity	NN
cord-296347-fanlvxqs	45	25	,	,	,
cord-296347-fanlvxqs	45	26	is	be	VBZ
cord-296347-fanlvxqs	45	27	also	also	RB
cord-296347-fanlvxqs	45	28	in	in	IN
cord-296347-fanlvxqs	45	29	place	place	NN
cord-296347-fanlvxqs	45	30	.	.	.
cord-296347-fanlvxqs	46	1	The	the	DT
cord-296347-fanlvxqs	46	2	adaptive	adaptive	JJ
cord-296347-fanlvxqs	46	3	immune	immune	JJ
cord-296347-fanlvxqs	46	4	system	system	NN
cord-296347-fanlvxqs	46	5	includes	include	VBZ
cord-296347-fanlvxqs	46	6	cells	cell	NNS
cord-296347-fanlvxqs	46	7	originated	originate	VBD
cord-296347-fanlvxqs	46	8	in	in	IN
cord-296347-fanlvxqs	46	9	the	the	DT
cord-296347-fanlvxqs	46	10	thymus	thymus	NN
cord-296347-fanlvxqs	46	11	,	,	,
cord-296347-fanlvxqs	46	12	the	the	DT
cord-296347-fanlvxqs	46	13	T	t	NN
cord-296347-fanlvxqs	46	14	lymphocytes	lymphocyte	NNS
cord-296347-fanlvxqs	46	15	,	,	,
cord-296347-fanlvxqs	46	16	and	and	CC
cord-296347-fanlvxqs	46	17	the	the	DT
cord-296347-fanlvxqs	46	18	bone	bone	NN
cord-296347-fanlvxqs	46	19	marrow	marrow	NN
cord-296347-fanlvxqs	46	20	-	-	HYPH
cord-296347-fanlvxqs	46	21	derived	derive	VBN
cord-296347-fanlvxqs	46	22	B	b	NN
cord-296347-fanlvxqs	46	23	lymphocytes	lymphocyte	NNS
cord-296347-fanlvxqs	46	24	(	(	-LRB-
cord-296347-fanlvxqs	46	25	B	b	NN
cord-296347-fanlvxqs	46	26	cells	cell	NNS
cord-296347-fanlvxqs	46	27	)	)	-RRB-
cord-296347-fanlvxqs	46	28	,	,	,
cord-296347-fanlvxqs	46	29	DCs	DCs	NNP
cord-296347-fanlvxqs	46	30	,	,	,
cord-296347-fanlvxqs	46	31	and	and	CC
cord-296347-fanlvxqs	46	32	macrophages	macrophage	NNS
cord-296347-fanlvxqs	46	33	.	.	.
cord-296347-fanlvxqs	47	1	The	the	DT
cord-296347-fanlvxqs	47	2	two	two	CD
cord-296347-fanlvxqs	47	3	subsets	subset	NNS
cord-296347-fanlvxqs	47	4	of	of	IN
cord-296347-fanlvxqs	47	5	T	T	NNP
cord-296347-fanlvxqs	47	6	lymphocytes	lymphocyte	NNS
cord-296347-fanlvxqs	47	7	,	,	,
cord-296347-fanlvxqs	47	8	CD8	CD8	NNP
cord-296347-fanlvxqs	47	9	þ	þ	NNP
cord-296347-fanlvxqs	47	10	and	and	CC
cord-296347-fanlvxqs	47	11	CD4	CD4	NNP
cord-296347-fanlvxqs	47	12	þ	þ	NNP
cord-296347-fanlvxqs	47	13	T	t	NN
cord-296347-fanlvxqs	47	14	cells	cell	NNS
cord-296347-fanlvxqs	47	15	,	,	,
cord-296347-fanlvxqs	47	16	possess	possess	VBP
cord-296347-fanlvxqs	47	17	distinct	distinct	JJ
cord-296347-fanlvxqs	47	18	T	T	NNP
cord-296347-fanlvxqs	47	19	cell	cell	NN
cord-296347-fanlvxqs	47	20	receptors	receptor	NNS
cord-296347-fanlvxqs	47	21	(	(	-LRB-
cord-296347-fanlvxqs	47	22	TCRs	TCRs	NNP
cord-296347-fanlvxqs	47	23	)	)	-RRB-
cord-296347-fanlvxqs	47	24	,	,	,
cord-296347-fanlvxqs	47	25	CD8	CD8	NNP
cord-296347-fanlvxqs	47	26	and	and	CC
cord-296347-fanlvxqs	47	27	CD4	CD4	NNP
cord-296347-fanlvxqs	47	28	,	,	,
cord-296347-fanlvxqs	47	29	respectively	respectively	RB
cord-296347-fanlvxqs	47	30	,	,	,
cord-296347-fanlvxqs	47	31	that	that	WDT
cord-296347-fanlvxqs	47	32	interact	interact	VBP
cord-296347-fanlvxqs	47	33	with	with	IN
cord-296347-fanlvxqs	47	34	their	-PRON-	PRP$
cord-296347-fanlvxqs	47	35	coreceptors	coreceptor	NNS
cord-296347-fanlvxqs	47	36	on	on	IN
cord-296347-fanlvxqs	47	37	the	the	DT
cord-296347-fanlvxqs	47	38	surface	surface	NN
cord-296347-fanlvxqs	47	39	of	of	IN
cord-296347-fanlvxqs	47	40	the	the	DT
cord-296347-fanlvxqs	47	41	target	target	NN
cord-296347-fanlvxqs	47	42	cell	cell	NN
cord-296347-fanlvxqs	47	43	,	,	,
cord-296347-fanlvxqs	47	44	the	the	DT
cord-296347-fanlvxqs	47	45	polymorphic	polymorphic	JJ
cord-296347-fanlvxqs	47	46	class	class	NN
cord-296347-fanlvxqs	47	47	I	i	NN
cord-296347-fanlvxqs	47	48	and	and	CC
cord-296347-fanlvxqs	47	49	class	class	NN
cord-296347-fanlvxqs	47	50	II	II	NNP
cord-296347-fanlvxqs	47	51	MHC	MHC	NNP
cord-296347-fanlvxqs	47	52	molecules	molecule	NNS
cord-296347-fanlvxqs	47	53	(	(	-LRB-
cord-296347-fanlvxqs	47	54	Ploegh	Ploegh	NNP
cord-296347-fanlvxqs	47	55	,	,	,
cord-296347-fanlvxqs	47	56	1998	1998	CD
cord-296347-fanlvxqs	47	57	)	)	-RRB-
cord-296347-fanlvxqs	47	58	.	.	.
cord-296347-fanlvxqs	48	1	Class	class	NN
cord-296347-fanlvxqs	48	2	I	-PRON-	PRP
cord-296347-fanlvxqs	48	3	MHC	MHC	NNP
cord-296347-fanlvxqs	48	4	molecules	molecule	NNS
cord-296347-fanlvxqs	48	5	are	be	VBP
cord-296347-fanlvxqs	48	6	expressed	express	VBN
cord-296347-fanlvxqs	48	7	by	by	IN
cord-296347-fanlvxqs	48	8	nearly	nearly	RB
cord-296347-fanlvxqs	48	9	all	all	DT
cord-296347-fanlvxqs	48	10	nucleated	nucleated	JJ
cord-296347-fanlvxqs	48	11	cells	cell	NNS
cord-296347-fanlvxqs	48	12	,	,	,
cord-296347-fanlvxqs	48	13	whereas	whereas	IN
cord-296347-fanlvxqs	48	14	class	class	NN
cord-296347-fanlvxqs	48	15	II	II	NNP
cord-296347-fanlvxqs	48	16	MHC	MHC	NNP
cord-296347-fanlvxqs	48	17	molecules	molecule	NNS
cord-296347-fanlvxqs	48	18	are	be	VBP
cord-296347-fanlvxqs	48	19	constitutively	constitutively	RB
cord-296347-fanlvxqs	48	20	expressed	express	VBN
cord-296347-fanlvxqs	48	21	only	only	RB
cord-296347-fanlvxqs	48	22	by	by	IN
cord-296347-fanlvxqs	48	23	professional	professional	JJ
cord-296347-fanlvxqs	48	24	antigen	antigen	NN
cord-296347-fanlvxqs	48	25	-	-	HYPH
cord-296347-fanlvxqs	48	26	presenting	present	VBG
cord-296347-fanlvxqs	48	27	cells	cell	NNS
cord-296347-fanlvxqs	48	28	(	(	-LRB-
cord-296347-fanlvxqs	48	29	APCs	apc	NNS
cord-296347-fanlvxqs	48	30	)	)	-RRB-
cord-296347-fanlvxqs	48	31	,	,	,
cord-296347-fanlvxqs	48	32	such	such	JJ
cord-296347-fanlvxqs	48	33	as	as	IN
cord-296347-fanlvxqs	48	34	macrophages	macrophage	NNS
cord-296347-fanlvxqs	48	35	,	,	,
cord-296347-fanlvxqs	48	36	B	b	NN
cord-296347-fanlvxqs	48	37	cells	cell	NNS
cord-296347-fanlvxqs	48	38	,	,	,
cord-296347-fanlvxqs	48	39	and	and	CC
cord-296347-fanlvxqs	48	40	DCs	dc	NNS
cord-296347-fanlvxqs	48	41	.	.	.
cord-296347-fanlvxqs	49	1	Class	Class	NNP
cord-296347-fanlvxqs	49	2	II	II	NNP
cord-296347-fanlvxqs	49	3	MHC	MHC	NNP
cord-296347-fanlvxqs	49	4	expression	expression	NN
cord-296347-fanlvxqs	49	5	however	however	RB
cord-296347-fanlvxqs	49	6	,	,	,
cord-296347-fanlvxqs	49	7	can	can	MD
cord-296347-fanlvxqs	49	8	be	be	VB
cord-296347-fanlvxqs	49	9	induced	induce	VBN
cord-296347-fanlvxqs	49	10	in	in	IN
cord-296347-fanlvxqs	49	11	many	many	JJ
cord-296347-fanlvxqs	49	12	cells	cell	NNS
cord-296347-fanlvxqs	49	13	,	,	,
cord-296347-fanlvxqs	49	14	in	in	IN
cord-296347-fanlvxqs	49	15	particular	particular	JJ
cord-296347-fanlvxqs	49	16	by	by	IN
cord-296347-fanlvxqs	49	17	IFN	IFN	NNP
cord-296347-fanlvxqs	49	18	-	-	HYPH
cord-296347-fanlvxqs	49	19	g	g	NN
cord-296347-fanlvxqs	49	20	treatment	treatment	NN
cord-296347-fanlvxqs	49	21	.	.	.
cord-296347-fanlvxqs	50	1	APCs	apc	NNS
cord-296347-fanlvxqs	50	2	can	can	MD
cord-296347-fanlvxqs	50	3	endocytose	endocytose	VB
cord-296347-fanlvxqs	50	4	,	,	,
cord-296347-fanlvxqs	50	5	process	process	NN
cord-296347-fanlvxqs	50	6	,	,	,
cord-296347-fanlvxqs	50	7	and	and	CC
cord-296347-fanlvxqs	50	8	display	display	NN
cord-296347-fanlvxqs	50	9	antigen	antigen	NN
cord-296347-fanlvxqs	50	10	in	in	IN
cord-296347-fanlvxqs	50	11	the	the	DT
cord-296347-fanlvxqs	50	12	context	context	NN
cord-296347-fanlvxqs	50	13	of	of	IN
cord-296347-fanlvxqs	50	14	class	class	NN
cord-296347-fanlvxqs	50	15	II	II	NNP
cord-296347-fanlvxqs	50	16	MHC	MHC	NNP
cord-296347-fanlvxqs	50	17	products	product	NNS
cord-296347-fanlvxqs	50	18	at	at	IN
cord-296347-fanlvxqs	50	19	their	-PRON-	PRP$
cord-296347-fanlvxqs	50	20	cell	cell	NN
cord-296347-fanlvxqs	50	21	surface	surface	NN
cord-296347-fanlvxqs	50	22	to	to	TO
cord-296347-fanlvxqs	50	23	activate	activate	VB
cord-296347-fanlvxqs	50	24	CD4	CD4	NNP
cord-296347-fanlvxqs	50	25	þ	þ	NNP
cord-296347-fanlvxqs	50	26	T	t	NN
cord-296347-fanlvxqs	50	27	cells	cell	NNS
cord-296347-fanlvxqs	50	28	.	.	.
cord-296347-fanlvxqs	51	1	In	in	IN
cord-296347-fanlvxqs	51	2	the	the	DT
cord-296347-fanlvxqs	51	3	presence	presence	NN
cord-296347-fanlvxqs	51	4	of	of	IN
cord-296347-fanlvxqs	51	5	antigen	antigen	NN
cord-296347-fanlvxqs	51	6	displayed	display	VBN
cord-296347-fanlvxqs	51	7	by	by	IN
cord-296347-fanlvxqs	51	8	the	the	DT
cord-296347-fanlvxqs	51	9	APC	APC	NNP
cord-296347-fanlvxqs	51	10	and	and	CC
cord-296347-fanlvxqs	51	11	the	the	DT
cord-296347-fanlvxqs	51	12	appropriate	appropriate	JJ
cord-296347-fanlvxqs	51	13	lymphocyte	lymphocyte	NN
cord-296347-fanlvxqs	51	14	costimulatory	costimulatory	NN
cord-296347-fanlvxqs	51	15	molecules	molecule	NNS
cord-296347-fanlvxqs	51	16	,	,	,
cord-296347-fanlvxqs	51	17	CD4	CD4	NNP
cord-296347-fanlvxqs	51	18	þ	þ	NNP
cord-296347-fanlvxqs	51	19	T	T	NNP
cord-296347-fanlvxqs	51	20	helper	helper	NN
cord-296347-fanlvxqs	51	21	(	(	-LRB-
cord-296347-fanlvxqs	51	22	T	T	NNP
cord-296347-fanlvxqs	51	23	H	H	NNP
cord-296347-fanlvxqs	51	24	)	)	-RRB-
cord-296347-fanlvxqs	51	25	cells	cell	NNS
cord-296347-fanlvxqs	51	26	produce	produce	VBP
cord-296347-fanlvxqs	51	27	cytokines	cytokine	NNS
cord-296347-fanlvxqs	51	28	that	that	WDT
cord-296347-fanlvxqs	51	29	'	'	''
cord-296347-fanlvxqs	51	30	'	'	``
cord-296347-fanlvxqs	51	31	help	help	NN
cord-296347-fanlvxqs	51	32	'	'	''
cord-296347-fanlvxqs	51	33	'	'	''
cord-296347-fanlvxqs	51	34	activate	activate	VB
cord-296347-fanlvxqs	51	35	other	other	JJ
cord-296347-fanlvxqs	51	36	cells	cell	NNS
cord-296347-fanlvxqs	51	37	:	:	:
cord-296347-fanlvxqs	52	1	T	T	NNP
cord-296347-fanlvxqs	52	2	H	h	NN
cord-296347-fanlvxqs	52	3	1	1	CD
cord-296347-fanlvxqs	52	4	(	(	-LRB-
cord-296347-fanlvxqs	52	5	or	or	CC
cord-296347-fanlvxqs	52	6	inflammatory	inflammatory	JJ
cord-296347-fanlvxqs	52	7	T	t	NN
cord-296347-fanlvxqs	52	8	cells	cell	NNS
cord-296347-fanlvxqs	52	9	)	)	-RRB-
cord-296347-fanlvxqs	52	10	activate	activate	VBP
cord-296347-fanlvxqs	52	11	macrophages	macrophage	NNS
cord-296347-fanlvxqs	52	12	to	to	TO
cord-296347-fanlvxqs	52	13	kill	kill	VB
cord-296347-fanlvxqs	52	14	the	the	DT
cord-296347-fanlvxqs	52	15	phagocytosed	phagocytosed	JJ
cord-296347-fanlvxqs	52	16	pathogens	pathogen	NNS
cord-296347-fanlvxqs	52	17	;	;	:
cord-296347-fanlvxqs	52	18	T	T	NNP
cord-296347-fanlvxqs	52	19	H	h	NN
cord-296347-fanlvxqs	52	20	2	2	CD
cord-296347-fanlvxqs	52	21	cells	cell	NNS
cord-296347-fanlvxqs	52	22	(	(	-LRB-
cord-296347-fanlvxqs	52	23	or	or	CC
cord-296347-fanlvxqs	52	24	helper	helper	NN
cord-296347-fanlvxqs	52	25	Tcells	Tcells	NNP
cord-296347-fanlvxqs	52	26	)	)	-RRB-
cord-296347-fanlvxqs	52	27	trigger	trigger	NN
cord-296347-fanlvxqs	52	28	Tand	Tand	NNP
cord-296347-fanlvxqs	52	29	B	B	NNP
cord-296347-fanlvxqs	52	30	cell	cell	NN
cord-296347-fanlvxqs	52	31	proliferation	proliferation	NN
cord-296347-fanlvxqs	52	32	and	and	CC
cord-296347-fanlvxqs	52	33	activate	activate	VB
cord-296347-fanlvxqs	52	34	the	the	DT
cord-296347-fanlvxqs	52	35	B	b	NN
cord-296347-fanlvxqs	52	36	cell	cell	NN
cord-296347-fanlvxqs	52	37	differentiation	differentiation	NN
cord-296347-fanlvxqs	52	38	program	program	NN
cord-296347-fanlvxqs	52	39	into	into	IN
cord-296347-fanlvxqs	52	40	antibody	antibody	NN
cord-296347-fanlvxqs	52	41	-	-	HYPH
cord-296347-fanlvxqs	52	42	producing	produce	VBG
cord-296347-fanlvxqs	52	43	plasma	plasma	NN
cord-296347-fanlvxqs	52	44	cells	cell	NNS
cord-296347-fanlvxqs	52	45	.	.	.
cord-296347-fanlvxqs	53	1	Furthermore	furthermore	RB
cord-296347-fanlvxqs	53	2	,	,	,
cord-296347-fanlvxqs	53	3	activation	activation	NN
cord-296347-fanlvxqs	53	4	of	of	IN
cord-296347-fanlvxqs	53	5	CD4	CD4	NNP
cord-296347-fanlvxqs	53	6	þ	þ	NNP
cord-296347-fanlvxqs	53	7	T	t	NN
cord-296347-fanlvxqs	53	8	H	h	NN
cord-296347-fanlvxqs	53	9	cells	cell	NNS
cord-296347-fanlvxqs	53	10	is	be	VBZ
cord-296347-fanlvxqs	53	11	carefully	carefully	RB
cord-296347-fanlvxqs	53	12	regulated	regulate	VBN
cord-296347-fanlvxqs	53	13	by	by	IN
cord-296347-fanlvxqs	53	14	a	a	DT
cord-296347-fanlvxqs	53	15	small	small	JJ
cord-296347-fanlvxqs	53	16	subset	subset	NN
cord-296347-fanlvxqs	53	17	of	of	IN
cord-296347-fanlvxqs	53	18	T	T	NNP
cord-296347-fanlvxqs	53	19	cells	cell	NNS
cord-296347-fanlvxqs	53	20	,	,	,
cord-296347-fanlvxqs	53	21	the	the	DT
cord-296347-fanlvxqs	53	22	regulatory	regulatory	JJ
cord-296347-fanlvxqs	53	23	T	t	NN
cord-296347-fanlvxqs	53	24	cells	cell	NNS
cord-296347-fanlvxqs	53	25	(	(	-LRB-
cord-296347-fanlvxqs	53	26	Tregs	Tregs	NNP
cord-296347-fanlvxqs	53	27	)	)	-RRB-
cord-296347-fanlvxqs	53	28	.	.	.
cord-296347-fanlvxqs	54	1	Regulatory	regulatory	JJ
cord-296347-fanlvxqs	54	2	T	t	NN
cord-296347-fanlvxqs	54	3	cells	cell	NNS
cord-296347-fanlvxqs	54	4	play	play	VBP
cord-296347-fanlvxqs	54	5	an	an	DT
cord-296347-fanlvxqs	54	6	important	important	JJ
cord-296347-fanlvxqs	54	7	role	role	NN
cord-296347-fanlvxqs	54	8	in	in	IN
cord-296347-fanlvxqs	54	9	downregulation	downregulation	NN
cord-296347-fanlvxqs	54	10	of	of	IN
cord-296347-fanlvxqs	54	11	the	the	DT
cord-296347-fanlvxqs	54	12	host	host	NN
cord-296347-fanlvxqs	54	13	immune	immune	JJ
cord-296347-fanlvxqs	54	14	response	response	NN
cord-296347-fanlvxqs	54	15	,	,	,
cord-296347-fanlvxqs	54	16	limiting	limit	VBG
cord-296347-fanlvxqs	54	17	the	the	DT
cord-296347-fanlvxqs	54	18	immunopathology	immunopathology	NN
cord-296347-fanlvxqs	54	19	resultant	resultant	JJ
cord-296347-fanlvxqs	54	20	from	from	IN
cord-296347-fanlvxqs	54	21	antipathogen	antipathogen	NNP
cord-296347-fanlvxqs	54	22	reactions	reaction	NNS
cord-296347-fanlvxqs	54	23	,	,	,
cord-296347-fanlvxqs	54	24	and	and	CC
cord-296347-fanlvxqs	54	25	preventing	prevent	VBG
cord-296347-fanlvxqs	54	26	autoimmune	autoimmune	JJ
cord-296347-fanlvxqs	54	27	disease	disease	NN
cord-296347-fanlvxqs	55	1	(	(	-LRB-
cord-296347-fanlvxqs	55	2	Beissert	Beissert	NNP
cord-296347-fanlvxqs	55	3	et	et	NNP
cord-296347-fanlvxqs	55	4	al	al	NNP
cord-296347-fanlvxqs	55	5	.	.	NNP
cord-296347-fanlvxqs	55	6	,	,	,
cord-296347-fanlvxqs	55	7	2006	2006	CD
cord-296347-fanlvxqs	55	8	;	;	:
cord-296347-fanlvxqs	55	9	Mills	Mills	NNPS
cord-296347-fanlvxqs	55	10	,	,	,
cord-296347-fanlvxqs	55	11	2004	2004	CD
cord-296347-fanlvxqs	55	12	)	)	-RRB-
cord-296347-fanlvxqs	55	13	.	.	.
cord-296347-fanlvxqs	56	1	In	in	IN
cord-296347-fanlvxqs	56	2	addition	addition	NN
cord-296347-fanlvxqs	56	3	to	to	IN
cord-296347-fanlvxqs	56	4	making	make	VBG
cord-296347-fanlvxqs	56	5	antibodies	antibody	NNS
cord-296347-fanlvxqs	56	6	,	,	,
cord-296347-fanlvxqs	56	7	B	b	NN
cord-296347-fanlvxqs	56	8	cells	cell	NNS
cord-296347-fanlvxqs	56	9	are	be	VBP
cord-296347-fanlvxqs	56	10	a	a	DT
cord-296347-fanlvxqs	56	11	special	special	JJ
cord-296347-fanlvxqs	56	12	kind	kind	NN
cord-296347-fanlvxqs	56	13	of	of	IN
cord-296347-fanlvxqs	56	14	APCs	apc	NNS
cord-296347-fanlvxqs	56	15	.	.	.
cord-296347-fanlvxqs	57	1	Unlike	unlike	IN
cord-296347-fanlvxqs	57	2	DCs	dc	NNS
cord-296347-fanlvxqs	57	3	and	and	CC
cord-296347-fanlvxqs	57	4	macrophages	macrophage	NNS
cord-296347-fanlvxqs	57	5	,	,	,
cord-296347-fanlvxqs	57	6	B	b	NN
cord-296347-fanlvxqs	57	7	cells	cell	NNS
cord-296347-fanlvxqs	57	8	are	be	VBP
cord-296347-fanlvxqs	57	9	not	not	RB
cord-296347-fanlvxqs	57	10	actively	actively	RB
cord-296347-fanlvxqs	57	11	phagocytic	phagocytic	JJ
cord-296347-fanlvxqs	57	12	.	.	.
cord-296347-fanlvxqs	58	1	However	however	RB
cord-296347-fanlvxqs	58	2	,	,	,
cord-296347-fanlvxqs	58	3	stimulation	stimulation	NN
cord-296347-fanlvxqs	58	4	of	of	IN
cord-296347-fanlvxqs	58	5	the	the	DT
cord-296347-fanlvxqs	58	6	membrane	membrane	NN
cord-296347-fanlvxqs	58	7	immunoglobulin	immunoglobulin	NN
cord-296347-fanlvxqs	58	8	(	(	-LRB-
cord-296347-fanlvxqs	58	9	mIg	mIg	NNS
cord-296347-fanlvxqs	58	10	)	)	-RRB-
cord-296347-fanlvxqs	58	11	antigen	antigen	NN
cord-296347-fanlvxqs	58	12	-	-	HYPH
cord-296347-fanlvxqs	58	13	recognition	recognition	NN
cord-296347-fanlvxqs	58	14	component	component	NN
cord-296347-fanlvxqs	58	15	of	of	IN
cord-296347-fanlvxqs	58	16	their	-PRON-	PRP$
cord-296347-fanlvxqs	58	17	B	b	NN
cord-296347-fanlvxqs	58	18	cell	cell	NN
cord-296347-fanlvxqs	58	19	receptor	receptor	NN
cord-296347-fanlvxqs	58	20	(	(	-LRB-
cord-296347-fanlvxqs	58	21	BCR	BCR	NNP
cord-296347-fanlvxqs	58	22	)	)	-RRB-
cord-296347-fanlvxqs	58	23	with	with	IN
cord-296347-fanlvxqs	58	24	cognate	cognate	JJ
cord-296347-fanlvxqs	58	25	antigen	antigen	NN
cord-296347-fanlvxqs	58	26	triggers	trigger	VBZ
cord-296347-fanlvxqs	58	27	the	the	DT
cord-296347-fanlvxqs	58	28	B	b	NN
cord-296347-fanlvxqs	58	29	cell	cell	NN
cord-296347-fanlvxqs	58	30	to	to	TO
cord-296347-fanlvxqs	58	31	capture	capture	VB
cord-296347-fanlvxqs	58	32	and	and	CC
cord-296347-fanlvxqs	58	33	deliver	deliver	VB
cord-296347-fanlvxqs	58	34	the	the	DT
cord-296347-fanlvxqs	58	35	antigen	antigen	NN
cord-296347-fanlvxqs	58	36	to	to	IN
cord-296347-fanlvxqs	58	37	class	class	NN
cord-296347-fanlvxqs	58	38	II	II	NNP
cord-296347-fanlvxqs	58	39	MHC	MHC	NNP
cord-296347-fanlvxqs	58	40	compartments	compartment	NNS
cord-296347-fanlvxqs	58	41	,	,	,
cord-296347-fanlvxqs	58	42	culminating	culminate	VBG
cord-296347-fanlvxqs	58	43	with	with	IN
cord-296347-fanlvxqs	58	44	antigen	antigen	NN
cord-296347-fanlvxqs	58	45	presentation	presentation	NN
cord-296347-fanlvxqs	58	46	for	for	IN
cord-296347-fanlvxqs	58	47	activation	activation	NN
cord-296347-fanlvxqs	58	48	of	of	IN
cord-296347-fanlvxqs	58	49	T	T	NNP
cord-296347-fanlvxqs	58	50	cells	cell	NNS
cord-296347-fanlvxqs	58	51	.	.	.
cord-296347-fanlvxqs	59	1	Bone	bone	NN
cord-296347-fanlvxqs	59	2	marrow	marrow	NN
cord-296347-fanlvxqs	59	3	-	-	HYPH
cord-296347-fanlvxqs	59	4	derived	derive	VBN
cord-296347-fanlvxqs	59	5	professional	professional	JJ
cord-296347-fanlvxqs	59	6	APCs	apc	NNS
cord-296347-fanlvxqs	59	7	include	include	VBP
cord-296347-fanlvxqs	59	8	macrophages	macrophage	NNS
cord-296347-fanlvxqs	59	9	and	and	CC
cord-296347-fanlvxqs	59	10	DCs	dc	NNS
cord-296347-fanlvxqs	59	11	.	.	.
cord-296347-fanlvxqs	60	1	Macrophages	macrophage	NNS
cord-296347-fanlvxqs	60	2	are	be	VBP
cord-296347-fanlvxqs	60	3	phagocytic	phagocytic	JJ
cord-296347-fanlvxqs	60	4	APCs	apc	NNS
cord-296347-fanlvxqs	60	5	with	with	IN
cord-296347-fanlvxqs	60	6	a	a	DT
cord-296347-fanlvxqs	60	7	low	low	JJ
cord-296347-fanlvxqs	60	8	basal	basal	NN
cord-296347-fanlvxqs	60	9	antigen	antigen	NN
cord-296347-fanlvxqs	60	10	-	-	HYPH
cord-296347-fanlvxqs	60	11	presenting	present	VBG
cord-296347-fanlvxqs	60	12	capacity	capacity	NN
cord-296347-fanlvxqs	60	13	-	-	HYPH
cord-296347-fanlvxqs	60	14	owing	owe	VBG
cord-296347-fanlvxqs	60	15	to	to	IN
cord-296347-fanlvxqs	60	16	low	low	JJ
cord-296347-fanlvxqs	60	17	surface	surface	NN
cord-296347-fanlvxqs	60	18	expression	expression	NN
cord-296347-fanlvxqs	60	19	of	of	IN
cord-296347-fanlvxqs	60	20	class	class	NN
cord-296347-fanlvxqs	60	21	II	II	NNP
cord-296347-fanlvxqs	60	22	MHC	MHC	NNP
cord-296347-fanlvxqs	60	23	and	and	CC
cord-296347-fanlvxqs	60	24	costimulatory	costimulatory	NNP
cord-296347-fanlvxqs	60	25	molecules	molecule	NNS
cord-296347-fanlvxqs	60	26	-	-	:
cord-296347-fanlvxqs	60	27	that	that	WDT
cord-296347-fanlvxqs	60	28	is	be	VBZ
cord-296347-fanlvxqs	60	29	induced	induce	VBN
cord-296347-fanlvxqs	60	30	on	on	IN
cord-296347-fanlvxqs	60	31	macrophage	macrophage	NN
cord-296347-fanlvxqs	60	32	activation	activation	NN
cord-296347-fanlvxqs	60	33	,	,	,
cord-296347-fanlvxqs	60	34	for	for	IN
cord-296347-fanlvxqs	60	35	instance	instance	NN
cord-296347-fanlvxqs	60	36	,	,	,
cord-296347-fanlvxqs	60	37	by	by	IN
cord-296347-fanlvxqs	60	38	IFN	IFN	NNP
cord-296347-fanlvxqs	60	39	-	-	HYPH
cord-296347-fanlvxqs	60	40	g	g	NNP
cord-296347-fanlvxqs	60	41	.	.	.
cord-296347-fanlvxqs	61	1	Macrophages	macrophage	NNS
cord-296347-fanlvxqs	61	2	reside	reside	VBP
cord-296347-fanlvxqs	61	3	in	in	IN
cord-296347-fanlvxqs	61	4	(	(	-LRB-
cord-296347-fanlvxqs	61	5	or	or	CC
cord-296347-fanlvxqs	61	6	are	be	VBP
cord-296347-fanlvxqs	61	7	recruited	recruit	VBN
cord-296347-fanlvxqs	61	8	to	to	IN
cord-296347-fanlvxqs	61	9	)	)	-RRB-
cord-296347-fanlvxqs	61	10	peripheral	peripheral	JJ
cord-296347-fanlvxqs	61	11	tissues	tissue	NNS
cord-296347-fanlvxqs	61	12	,	,	,
cord-296347-fanlvxqs	61	13	where	where	WRB
cord-296347-fanlvxqs	61	14	they	-PRON-	PRP
cord-296347-fanlvxqs	61	15	phagocytose	phagocytose	VBD
cord-296347-fanlvxqs	61	16	and	and	CC
cord-296347-fanlvxqs	61	17	clear	clear	JJ
cord-296347-fanlvxqs	61	18	pathogens	pathogen	NNS
cord-296347-fanlvxqs	61	19	.	.	.
cord-296347-fanlvxqs	62	1	Phagocytosis	Phagocytosis	NNP
cord-296347-fanlvxqs	62	2	,	,	,
cord-296347-fanlvxqs	62	3	in	in	IN
cord-296347-fanlvxqs	62	4	turn	turn	NN
cord-296347-fanlvxqs	62	5	,	,	,
cord-296347-fanlvxqs	62	6	induces	induce	VBZ
cord-296347-fanlvxqs	62	7	release	release	NN
cord-296347-fanlvxqs	62	8	of	of	IN
cord-296347-fanlvxqs	62	9	proinflammatory	proinflammatory	JJ
cord-296347-fanlvxqs	62	10	cytokines	cytokine	NNS
cord-296347-fanlvxqs	62	11	like	like	IN
cord-296347-fanlvxqs	62	12	IFN	IFN	NNP
cord-296347-fanlvxqs	62	13	-	-	HYPH
cord-296347-fanlvxqs	62	14	g	g	NNP
cord-296347-fanlvxqs	62	15	that	that	WDT
cord-296347-fanlvxqs	62	16	turn	turn	VBP
cord-296347-fanlvxqs	62	17	macrophages	macrophage	NNS
cord-296347-fanlvxqs	62	18	into	into	IN
cord-296347-fanlvxqs	62	19	potent	potent	JJ
cord-296347-fanlvxqs	62	20	APCs	apc	NNS
cord-296347-fanlvxqs	62	21	,	,	,
cord-296347-fanlvxqs	62	22	resulting	result	VBG
cord-296347-fanlvxqs	62	23	in	in	IN
cord-296347-fanlvxqs	62	24	initiation	initiation	NN
cord-296347-fanlvxqs	62	25	of	of	IN
cord-296347-fanlvxqs	62	26	CD4	CD4	NNP
cord-296347-fanlvxqs	62	27	þ	þ	NNP
cord-296347-fanlvxqs	62	28	T	T	NNP
cord-296347-fanlvxqs	62	29	cell	cell	NN
cord-296347-fanlvxqs	62	30	activation	activation	NN
cord-296347-fanlvxqs	62	31	.	.	.
cord-296347-fanlvxqs	63	1	Dendritic	dendritic	JJ
cord-296347-fanlvxqs	63	2	cells	cell	NNS
cord-296347-fanlvxqs	63	3	,	,	,
cord-296347-fanlvxqs	63	4	the	the	DT
cord-296347-fanlvxqs	63	5	consummate	consummate	JJ
cord-296347-fanlvxqs	63	6	professional	professional	JJ
cord-296347-fanlvxqs	63	7	APCs	apc	NNS
cord-296347-fanlvxqs	63	8	,	,	,
cord-296347-fanlvxqs	63	9	travel	travel	VBP
cord-296347-fanlvxqs	63	10	through	through	IN
cord-296347-fanlvxqs	63	11	the	the	DT
cord-296347-fanlvxqs	63	12	periphery	periphery	NN
cord-296347-fanlvxqs	63	13	,	,	,
cord-296347-fanlvxqs	63	14	sampling	sample	VBG
cord-296347-fanlvxqs	63	15	all	all	DT
cord-296347-fanlvxqs	63	16	tissues	tissue	NNS
cord-296347-fanlvxqs	63	17	for	for	IN
cord-296347-fanlvxqs	63	18	prospective	prospective	JJ
cord-296347-fanlvxqs	63	19	invaders	invader	NNS
cord-296347-fanlvxqs	63	20	.	.	.
cord-296347-fanlvxqs	64	1	Immature	immature	JJ
cord-296347-fanlvxqs	64	2	DCs	dc	NNS
cord-296347-fanlvxqs	64	3	phagocytose	phagocytose	JJ
cord-296347-fanlvxqs	64	4	pathogens	pathogen	NNS
cord-296347-fanlvxqs	64	5	and	and	CC
cord-296347-fanlvxqs	64	6	home	home	NN
cord-296347-fanlvxqs	64	7	to	to	IN
cord-296347-fanlvxqs	64	8	the	the	DT
cord-296347-fanlvxqs	64	9	nearest	near	JJS
cord-296347-fanlvxqs	64	10	lymphoid	lymphoid	JJ
cord-296347-fanlvxqs	64	11	organ	organ	NN
cord-296347-fanlvxqs	64	12	to	to	TO
cord-296347-fanlvxqs	64	13	'	'	''
cord-296347-fanlvxqs	64	14	'	'	``
cord-296347-fanlvxqs	64	15	educate	educate	VB
cord-296347-fanlvxqs	64	16	'	'	''
cord-296347-fanlvxqs	64	17	'	'	''
cord-296347-fanlvxqs	64	18	(	(	-LRB-
cord-296347-fanlvxqs	64	19	prime	prime	JJ
cord-296347-fanlvxqs	64	20	)	)	-RRB-
cord-296347-fanlvxqs	64	21	naïve	naïve	JJ
cord-296347-fanlvxqs	64	22	CD8	CD8	NNP
cord-296347-fanlvxqs	64	23	þ	þ	NNP
cord-296347-fanlvxqs	64	24	T	t	NN
cord-296347-fanlvxqs	64	25	cells	cell	NNS
cord-296347-fanlvxqs	64	26	by	by	IN
cord-296347-fanlvxqs	64	27	cross	cross	NN
cord-296347-fanlvxqs	64	28	-	-	JJ
cord-296347-fanlvxqs	64	29	presenting	presenting	JJ
cord-296347-fanlvxqs	64	30	antigen	antigen	NN
cord-296347-fanlvxqs	64	31	in	in	IN
cord-296347-fanlvxqs	64	32	the	the	DT
cord-296347-fanlvxqs	64	33	context	context	NN
cord-296347-fanlvxqs	64	34	of	of	IN
cord-296347-fanlvxqs	64	35	class	class	NN
cord-296347-fanlvxqs	65	1	I	-PRON-	PRP
cord-296347-fanlvxqs	65	2	MHC	MHC	NNP
cord-296347-fanlvxqs	65	3	molecules	molecule	NNS
cord-296347-fanlvxqs	65	4	-	-	:
cord-296347-fanlvxqs	65	5	a	a	DT
cord-296347-fanlvxqs	65	6	process	process	NN
cord-296347-fanlvxqs	65	7	described	describe	VBN
cord-296347-fanlvxqs	65	8	in	in	IN
cord-296347-fanlvxqs	65	9	more	more	JJR
cord-296347-fanlvxqs	65	10	detail	detail	NN
cord-296347-fanlvxqs	65	11	later	later	RB
cord-296347-fanlvxqs	65	12	.	.	.
cord-296347-fanlvxqs	66	1	Mature	mature	JJ
cord-296347-fanlvxqs	66	2	DCs	dc	NNS
cord-296347-fanlvxqs	66	3	can	can	MD
cord-296347-fanlvxqs	66	4	also	also	RB
cord-296347-fanlvxqs	66	5	prime	prime	JJ
cord-296347-fanlvxqs	66	6	naïve	naïve	JJ
cord-296347-fanlvxqs	66	7	CD4	CD4	NNP
cord-296347-fanlvxqs	66	8	þ	þ	NNP
cord-296347-fanlvxqs	66	9	T	t	NN
cord-296347-fanlvxqs	66	10	cells	cell	NNS
cord-296347-fanlvxqs	66	11	.	.	.
cord-296347-fanlvxqs	67	1	Like	like	IN
cord-296347-fanlvxqs	67	2	resting	rest	VBG
cord-296347-fanlvxqs	67	3	macrophages	macrophage	NNS
cord-296347-fanlvxqs	67	4	,	,	,
cord-296347-fanlvxqs	67	5	immature	immature	JJ
cord-296347-fanlvxqs	67	6	DCs	dc	NNS
cord-296347-fanlvxqs	67	7	have	have	VBP
cord-296347-fanlvxqs	67	8	very	very	RB
cord-296347-fanlvxqs	67	9	low	low	JJ
cord-296347-fanlvxqs	67	10	antigen	antigen	NN
cord-296347-fanlvxqs	67	11	-	-	HYPH
cord-296347-fanlvxqs	67	12	presenting	present	VBG
cord-296347-fanlvxqs	67	13	capability	capability	NN
cord-296347-fanlvxqs	67	14	,	,	,
cord-296347-fanlvxqs	67	15	and	and	CC
cord-296347-fanlvxqs	67	16	only	only	RB
cord-296347-fanlvxqs	67	17	on	on	IN
cord-296347-fanlvxqs	67	18	exposure	exposure	NN
cord-296347-fanlvxqs	67	19	to	to	IN
cord-296347-fanlvxqs	67	20	maturation	maturation	NN
cord-296347-fanlvxqs	67	21	signals	signal	NNS
cord-296347-fanlvxqs	67	22	[	[	-LRB-
cord-296347-fanlvxqs	67	23	such	such	JJ
cord-296347-fanlvxqs	67	24	as	as	IN
cord-296347-fanlvxqs	67	25	lipopolysaccharide	lipopolysaccharide	NN
cord-296347-fanlvxqs	67	26	(	(	-LRB-
cord-296347-fanlvxqs	67	27	LPS	LPS	NNP
cord-296347-fanlvxqs	67	28	)	)	-RRB-
cord-296347-fanlvxqs	67	29	on	on	IN
cord-296347-fanlvxqs	67	30	bacterial	bacterial	JJ
cord-296347-fanlvxqs	67	31	surfaces	surface	NNS
cord-296347-fanlvxqs	67	32	]	]	-RRB-
cord-296347-fanlvxqs	68	1	does	do	VBZ
cord-296347-fanlvxqs	68	2	internalized	internalize	VBN
cord-296347-fanlvxqs	68	3	antigen	antigen	NN
cord-296347-fanlvxqs	68	4	get	get	VB
cord-296347-fanlvxqs	68	5	loaded	load	VBN
cord-296347-fanlvxqs	68	6	into	into	IN
cord-296347-fanlvxqs	68	7	class	class	NN
cord-296347-fanlvxqs	68	8	II	II	NNP
cord-296347-fanlvxqs	68	9	MHC	MHC	NNP
cord-296347-fanlvxqs	68	10	products	product	NNS
cord-296347-fanlvxqs	68	11	and	and	CC
cord-296347-fanlvxqs	68	12	get	get	VBP
cord-296347-fanlvxqs	68	13	displayed	display	VBN
cord-296347-fanlvxqs	68	14	at	at	IN
cord-296347-fanlvxqs	68	15	the	the	DT
cord-296347-fanlvxqs	68	16	cell	cell	NN
cord-296347-fanlvxqs	68	17	surface	surface	NN
cord-296347-fanlvxqs	68	18	to	to	IN
cord-296347-fanlvxqs	68	19	CD4	CD4	NNP
cord-296347-fanlvxqs	68	20	þ	þ	NNP
cord-296347-fanlvxqs	68	21	T	t	NN
cord-296347-fanlvxqs	68	22	cells	cell	NNS
cord-296347-fanlvxqs	68	23	(	(	-LRB-
cord-296347-fanlvxqs	68	24	Bryant	Bryant	NNP
cord-296347-fanlvxqs	68	25	and	and	CC
cord-296347-fanlvxqs	68	26	Ploegh	Ploegh	NNP
cord-296347-fanlvxqs	68	27	,	,	,
cord-296347-fanlvxqs	68	28	2004	2004	CD
cord-296347-fanlvxqs	68	29	;	;	:
cord-296347-fanlvxqs	69	1	Stockwin	Stockwin	NNP
cord-296347-fanlvxqs	69	2	et	et	NNP
cord-296347-fanlvxqs	69	3	al	al	NNP
cord-296347-fanlvxqs	69	4	.	.	.
cord-296347-fanlvxqs	70	1	,	,	,
cord-296347-fanlvxqs	70	2	2000	2000	CD
cord-296347-fanlvxqs	70	3	)	)	-RRB-
cord-296347-fanlvxqs	70	4	.	.	.
cord-296347-fanlvxqs	70	5	'	'	''
cord-296347-fanlvxqs	70	6	'	'	''
cord-296347-fanlvxqs	70	7	Educated	educate	VBN
cord-296347-fanlvxqs	70	8	'	'	''
cord-296347-fanlvxqs	70	9	'	'	''
cord-296347-fanlvxqs	70	10	(	(	-LRB-
cord-296347-fanlvxqs	70	11	antigen	antigen	NN
cord-296347-fanlvxqs	70	12	-	-	HYPH
cord-296347-fanlvxqs	70	13	specific	specific	JJ
cord-296347-fanlvxqs	70	14	)	)	-RRB-
cord-296347-fanlvxqs	71	1	CD8	CD8	NNP
cord-296347-fanlvxqs	71	2	þ	þ	NNP
cord-296347-fanlvxqs	71	3	T	T	NNP
cord-296347-fanlvxqs	71	4	lymphocytes	lymphocyte	NNS
cord-296347-fanlvxqs	71	5	survey	survey	VBP
cord-296347-fanlvxqs	71	6	all	all	DT
cord-296347-fanlvxqs	71	7	cells	cell	NNS
cord-296347-fanlvxqs	71	8	in	in	IN
cord-296347-fanlvxqs	71	9	the	the	DT
cord-296347-fanlvxqs	71	10	body	body	NN
cord-296347-fanlvxqs	71	11	,	,	,
cord-296347-fanlvxqs	71	12	ready	ready	JJ
cord-296347-fanlvxqs	71	13	to	to	TO
cord-296347-fanlvxqs	71	14	destroy	destroy	VB
cord-296347-fanlvxqs	71	15	any	any	DT
cord-296347-fanlvxqs	71	16	that	that	WDT
cord-296347-fanlvxqs	71	17	displays	display	VBZ
cord-296347-fanlvxqs	71	18	signs	sign	NNS
cord-296347-fanlvxqs	71	19	of	of	IN
cord-296347-fanlvxqs	71	20	the	the	DT
cord-296347-fanlvxqs	71	21	presence	presence	NN
cord-296347-fanlvxqs	71	22	of	of	IN
cord-296347-fanlvxqs	71	23	cellular	cellular	JJ
cord-296347-fanlvxqs	71	24	alterations	alteration	NNS
cord-296347-fanlvxqs	71	25	(	(	-LRB-
cord-296347-fanlvxqs	71	26	such	such	JJ
cord-296347-fanlvxqs	71	27	as	as	IN
cord-296347-fanlvxqs	71	28	viral	viral	JJ
cord-296347-fanlvxqs	71	29	and	and	CC
cord-296347-fanlvxqs	71	30	tumor	tumor	NN
cord-296347-fanlvxqs	71	31	peptides	peptide	NNS
cord-296347-fanlvxqs	71	32	)	)	-RRB-
cord-296347-fanlvxqs	71	33	within	within	IN
cord-296347-fanlvxqs	71	34	their	-PRON-	PRP$
cord-296347-fanlvxqs	71	35	surface	surface	NN
cord-296347-fanlvxqs	71	36	class	class	NN
cord-296347-fanlvxqs	71	37	I	-PRON-	PRP
cord-296347-fanlvxqs	71	38	MHC	MHC	NNP
cord-296347-fanlvxqs	71	39	molecules	molecule	NNS
cord-296347-fanlvxqs	71	40	(	(	-LRB-
cord-296347-fanlvxqs	71	41	Andersen	Andersen	NNP
cord-296347-fanlvxqs	71	42	et	et	NNP
cord-296347-fanlvxqs	71	43	al	al	NNP
cord-296347-fanlvxqs	71	44	.	.	NNP
cord-296347-fanlvxqs	71	45	,	,	,
cord-296347-fanlvxqs	71	46	2006	2006	CD
cord-296347-fanlvxqs	71	47	;	;	:
cord-296347-fanlvxqs	71	48	Castelli	Castelli	NNP
cord-296347-fanlvxqs	71	49	et	et	NNP
cord-296347-fanlvxqs	71	50	al	al	NNP
cord-296347-fanlvxqs	71	51	.	.	NNP
cord-296347-fanlvxqs	71	52	,	,	,
cord-296347-fanlvxqs	71	53	2000	2000	CD
cord-296347-fanlvxqs	71	54	)	)	-RRB-
cord-296347-fanlvxqs	71	55	.	.	.
cord-296347-fanlvxqs	72	1	Antigen	antigen	NN
cord-296347-fanlvxqs	72	2	-	-	HYPH
cord-296347-fanlvxqs	72	3	specific	specific	JJ
cord-296347-fanlvxqs	72	4	CD4	CD4	NNP
cord-296347-fanlvxqs	72	5	þ	þ	NNP
cord-296347-fanlvxqs	72	6	T	t	NN
cord-296347-fanlvxqs	72	7	lymphocytes	lymphocyte	NNS
cord-296347-fanlvxqs	72	8	can	can	MD
cord-296347-fanlvxqs	72	9	coordinate	coordinate	VB
cord-296347-fanlvxqs	72	10	macrophage	macrophage	NN
cord-296347-fanlvxqs	72	11	bactericidal	bactericidal	JJ
cord-296347-fanlvxqs	72	12	properties	property	NNS
cord-296347-fanlvxqs	72	13	,	,	,
cord-296347-fanlvxqs	72	14	activation	activation	NN
cord-296347-fanlvxqs	72	15	of	of	IN
cord-296347-fanlvxqs	72	16	T	t	NN
cord-296347-fanlvxqs	72	17	and	and	CC
cord-296347-fanlvxqs	72	18	B	b	NN
cord-296347-fanlvxqs	72	19	lymphocytes	lymphocyte	NNS
cord-296347-fanlvxqs	72	20	,	,	,
cord-296347-fanlvxqs	72	21	and	and	CC
cord-296347-fanlvxqs	72	22	antibody	antibody	NN
cord-296347-fanlvxqs	72	23	production	production	NN
cord-296347-fanlvxqs	72	24	.	.	.
cord-296347-fanlvxqs	73	1	Not	not	RB
cord-296347-fanlvxqs	73	2	only	only	RB
cord-296347-fanlvxqs	73	3	do	do	VBP
cord-296347-fanlvxqs	73	4	the	the	DT
cord-296347-fanlvxqs	73	5	cells	cell	NNS
cord-296347-fanlvxqs	73	6	of	of	IN
cord-296347-fanlvxqs	73	7	the	the	DT
cord-296347-fanlvxqs	73	8	adaptive	adaptive	JJ
cord-296347-fanlvxqs	73	9	immune	immune	JJ
cord-296347-fanlvxqs	73	10	system	system	NN
cord-296347-fanlvxqs	73	11	provide	provide	VBP
cord-296347-fanlvxqs	73	12	a	a	DT
cord-296347-fanlvxqs	73	13	more	more	RBR
cord-296347-fanlvxqs	73	14	elaborate	elaborate	JJ
cord-296347-fanlvxqs	73	15	defense	defense	NN
cord-296347-fanlvxqs	73	16	,	,	,
cord-296347-fanlvxqs	73	17	but	but	CC
cord-296347-fanlvxqs	73	18	also	also	RB
cord-296347-fanlvxqs	73	19	an	an	DT
cord-296347-fanlvxqs	73	20	increased	increase	VBN
cord-296347-fanlvxqs	73	21	level	level	NN
cord-296347-fanlvxqs	73	22	of	of	IN
cord-296347-fanlvxqs	73	23	protection	protection	NN
cord-296347-fanlvxqs	73	24	from	from	IN
cord-296347-fanlvxqs	73	25	a	a	DT
cord-296347-fanlvxqs	73	26	subsequent	subsequent	JJ
cord-296347-fanlvxqs	73	27	reinfection	reinfection	NN
cord-296347-fanlvxqs	73	28	with	with	IN
cord-296347-fanlvxqs	73	29	the	the	DT
cord-296347-fanlvxqs	73	30	same	same	JJ
cord-296347-fanlvxqs	73	31	pathogen	pathogen	NN
cord-296347-fanlvxqs	73	32	,	,	,
cord-296347-fanlvxqs	73	33	the	the	DT
cord-296347-fanlvxqs	73	34	bedrock	bedrock	NN
cord-296347-fanlvxqs	73	35	principle	principle	NN
cord-296347-fanlvxqs	73	36	of	of	IN
cord-296347-fanlvxqs	73	37	vaccine	vaccine	NN
cord-296347-fanlvxqs	73	38	strategies	strategy	NNS
cord-296347-fanlvxqs	73	39	(	(	-LRB-
cord-296347-fanlvxqs	73	40	Crotty	Crotty	NNP
cord-296347-fanlvxqs	73	41	and	and	CC
cord-296347-fanlvxqs	73	42	Ahmed	Ahmed	NNP
cord-296347-fanlvxqs	73	43	,	,	,
cord-296347-fanlvxqs	73	44	2004	2004	CD
cord-296347-fanlvxqs	73	45	;	;	:
cord-296347-fanlvxqs	73	46	Pulendran	Pulendran	NNP
cord-296347-fanlvxqs	73	47	and	and	CC
cord-296347-fanlvxqs	73	48	Ahmed	Ahmed	NNP
cord-296347-fanlvxqs	73	49	,	,	,
cord-296347-fanlvxqs	73	50	2006	2006	CD
cord-296347-fanlvxqs	73	51	)	)	-RRB-
cord-296347-fanlvxqs	73	52	.	.	.
cord-296347-fanlvxqs	74	1	Adding	add	VBG
cord-296347-fanlvxqs	74	2	to	to	IN
cord-296347-fanlvxqs	74	3	the	the	DT
cord-296347-fanlvxqs	74	4	complexity	complexity	NN
cord-296347-fanlvxqs	74	5	of	of	IN
cord-296347-fanlvxqs	74	6	the	the	DT
cord-296347-fanlvxqs	74	7	immune	immune	JJ
cord-296347-fanlvxqs	74	8	system	system	NN
cord-296347-fanlvxqs	74	9	is	be	VBZ
cord-296347-fanlvxqs	74	10	the	the	DT
cord-296347-fanlvxqs	74	11	cross	cross	NN
cord-296347-fanlvxqs	74	12	talk	talk	NN
cord-296347-fanlvxqs	74	13	between	between	IN
cord-296347-fanlvxqs	74	14	innate	innate	JJ
cord-296347-fanlvxqs	74	15	and	and	CC
cord-296347-fanlvxqs	74	16	adaptive	adaptive	JJ
cord-296347-fanlvxqs	74	17	immunity	immunity	NN
cord-296347-fanlvxqs	74	18	,	,	,
cord-296347-fanlvxqs	74	19	which	which	WDT
cord-296347-fanlvxqs	74	20	is	be	VBZ
cord-296347-fanlvxqs	74	21	crucial	crucial	JJ
cord-296347-fanlvxqs	74	22	in	in	IN
cord-296347-fanlvxqs	74	23	eliciting	elicit	VBG
cord-296347-fanlvxqs	74	24	an	an	DT
cord-296347-fanlvxqs	74	25	effective	effective	JJ
cord-296347-fanlvxqs	74	26	immune	immune	JJ
cord-296347-fanlvxqs	74	27	response	response	NN
cord-296347-fanlvxqs	74	28	(	(	-LRB-
cord-296347-fanlvxqs	74	29	Zingoni	Zingoni	NNP
cord-296347-fanlvxqs	74	30	et	et	FW
cord-296347-fanlvxqs	74	31	al	al	NNP
cord-296347-fanlvxqs	74	32	.	.	NNP
cord-296347-fanlvxqs	74	33	,	,	,
cord-296347-fanlvxqs	74	34	2005	2005	CD
cord-296347-fanlvxqs	74	35	)	)	-RRB-
cord-296347-fanlvxqs	74	36	.	.	.
cord-296347-fanlvxqs	75	1	As	as	IN
cord-296347-fanlvxqs	75	2	mentioned	mention	VBN
cord-296347-fanlvxqs	75	3	,	,	,
cord-296347-fanlvxqs	75	4	phagocytes	phagocyte	NNS
cord-296347-fanlvxqs	75	5	release	release	VBP
cord-296347-fanlvxqs	75	6	cytokines	cytokine	NNS
cord-296347-fanlvxqs	75	7	that	that	WDT
cord-296347-fanlvxqs	75	8	stimulate	stimulate	VBP
cord-296347-fanlvxqs	75	9	the	the	DT
cord-296347-fanlvxqs	75	10	adaptive	adaptive	JJ
cord-296347-fanlvxqs	75	11	response	response	NN
cord-296347-fanlvxqs	75	12	.	.	.
cord-296347-fanlvxqs	76	1	Conversely	conversely	RB
cord-296347-fanlvxqs	76	2	,	,	,
cord-296347-fanlvxqs	76	3	on	on	IN
cord-296347-fanlvxqs	76	4	activation	activation	NN
cord-296347-fanlvxqs	76	5	by	by	IN
cord-296347-fanlvxqs	76	6	antigen	antigen	NN
cord-296347-fanlvxqs	76	7	recognition	recognition	NN
cord-296347-fanlvxqs	76	8	,	,	,
cord-296347-fanlvxqs	76	9	T	t	NN
cord-296347-fanlvxqs	76	10	cells	cell	NNS
cord-296347-fanlvxqs	76	11	synthesize	synthesize	VBP
cord-296347-fanlvxqs	76	12	and	and	CC
cord-296347-fanlvxqs	76	13	secrete	secrete	JJ
cord-296347-fanlvxqs	76	14	cytokines	cytokine	NNS
cord-296347-fanlvxqs	76	15	that	that	WDT
cord-296347-fanlvxqs	76	16	activate	activate	VBP
cord-296347-fanlvxqs	76	17	macrophages	macrophage	NNS
cord-296347-fanlvxqs	76	18	,	,	,
cord-296347-fanlvxqs	76	19	increasing	increase	VBG
cord-296347-fanlvxqs	76	20	their	-PRON-	PRP$
cord-296347-fanlvxqs	76	21	ability	ability	NN
cord-296347-fanlvxqs	76	22	to	to	TO
cord-296347-fanlvxqs	76	23	kill	kill	VB
cord-296347-fanlvxqs	76	24	ingested	ingested	JJ
cord-296347-fanlvxqs	76	25	microbes	microbe	NNS
cord-296347-fanlvxqs	76	26	,	,	,
cord-296347-fanlvxqs	76	27	an	an	DT
cord-296347-fanlvxqs	76	28	innate	innate	JJ
cord-296347-fanlvxqs	76	29	immune	immune	JJ
cord-296347-fanlvxqs	76	30	response	response	NN
cord-296347-fanlvxqs	76	31	(	(	-LRB-
cord-296347-fanlvxqs	76	32	Munz	Munz	NNP
cord-296347-fanlvxqs	76	33	et	et	NNP
cord-296347-fanlvxqs	76	34	al	al	NNP
cord-296347-fanlvxqs	76	35	.	.	NNP
cord-296347-fanlvxqs	76	36	,	,	,
cord-296347-fanlvxqs	76	37	2005	2005	CD
cord-296347-fanlvxqs	76	38	;	;	:
cord-296347-fanlvxqs	76	39	Salazar	Salazar	NNP
cord-296347-fanlvxqs	76	40	-	-	HYPH
cord-296347-fanlvxqs	76	41	Mather	Mather	NNP
cord-296347-fanlvxqs	76	42	and	and	CC
cord-296347-fanlvxqs	76	43	Hokeness	Hokeness	NNP
cord-296347-fanlvxqs	76	44	,	,	,
cord-296347-fanlvxqs	76	45	2003	2003	CD
cord-296347-fanlvxqs	76	46	)	)	-RRB-
cord-296347-fanlvxqs	76	47	.	.	.
cord-296347-fanlvxqs	77	1	The	the	DT
cord-296347-fanlvxqs	77	2	vertebrate	vertebrate	JJ
cord-296347-fanlvxqs	77	3	immune	immune	JJ
cord-296347-fanlvxqs	77	4	system	system	NN
cord-296347-fanlvxqs	77	5	,	,	,
cord-296347-fanlvxqs	77	6	therefore	therefore	RB
cord-296347-fanlvxqs	77	7	,	,	,
cord-296347-fanlvxqs	77	8	is	be	VBZ
cord-296347-fanlvxqs	77	9	the	the	DT
cord-296347-fanlvxqs	77	10	appropriate	appropriate	JJ
cord-296347-fanlvxqs	77	11	battleground	battleground	NN
cord-296347-fanlvxqs	77	12	for	for	IN
cord-296347-fanlvxqs	77	13	microbial	microbial	JJ
cord-296347-fanlvxqs	77	14	pathogens	pathogen	NNS
cord-296347-fanlvxqs	77	15	,	,	,
cord-296347-fanlvxqs	77	16	selecting	select	VBG
cord-296347-fanlvxqs	77	17	for	for	IN
cord-296347-fanlvxqs	77	18	those	those	DT
cord-296347-fanlvxqs	77	19	that	that	WDT
cord-296347-fanlvxqs	77	20	devise	devise	VBP
cord-296347-fanlvxqs	77	21	successful	successful	JJ
cord-296347-fanlvxqs	77	22	strategies	strategy	NNS
cord-296347-fanlvxqs	77	23	to	to	TO
cord-296347-fanlvxqs	77	24	avoid	avoid	VB
cord-296347-fanlvxqs	77	25	detection	detection	NN
cord-296347-fanlvxqs	77	26	and	and	CC
cord-296347-fanlvxqs	77	27	elimination	elimination	NN
cord-296347-fanlvxqs	77	28	(	(	-LRB-
cord-296347-fanlvxqs	77	29	Hilleman	Hilleman	NNP
cord-296347-fanlvxqs	77	30	,	,	,
cord-296347-fanlvxqs	77	31	2004	2004	CD
cord-296347-fanlvxqs	77	32	;	;	:
cord-296347-fanlvxqs	77	33	Ploegh	Ploegh	NNP
cord-296347-fanlvxqs	77	34	,	,	,
cord-296347-fanlvxqs	77	35	1998	1998	CD
cord-296347-fanlvxqs	77	36	)	)	-RRB-
cord-296347-fanlvxqs	77	37	.	.	.
cord-296347-fanlvxqs	78	1	Intracellular	Intracellular	NNP
cord-296347-fanlvxqs	78	2	pathogens	pathogen	NNS
cord-296347-fanlvxqs	78	3	have	have	VBP
cord-296347-fanlvxqs	78	4	evolved	evolve	VBN
cord-296347-fanlvxqs	78	5	sophisticated	sophisticated	JJ
cord-296347-fanlvxqs	78	6	mechanisms	mechanism	NNS
cord-296347-fanlvxqs	78	7	to	to	TO
cord-296347-fanlvxqs	78	8	subvert	subvert	VB
cord-296347-fanlvxqs	78	9	host	host	NN
cord-296347-fanlvxqs	78	10	processes	process	NNS
cord-296347-fanlvxqs	78	11	to	to	TO
cord-296347-fanlvxqs	78	12	ensure	ensure	VB
cord-296347-fanlvxqs	78	13	their	-PRON-	PRP$
cord-296347-fanlvxqs	78	14	own	own	JJ
cord-296347-fanlvxqs	78	15	replication	replication	NN
cord-296347-fanlvxqs	78	16	and	and	CC
cord-296347-fanlvxqs	78	17	transmission	transmission	NN
cord-296347-fanlvxqs	78	18	.	.	.
cord-296347-fanlvxqs	79	1	The	the	DT
cord-296347-fanlvxqs	79	2	initial	initial	JJ
cord-296347-fanlvxqs	79	3	hurdle	hurdle	NN
cord-296347-fanlvxqs	79	4	is	be	VBZ
cord-296347-fanlvxqs	79	5	entry	entry	NN
cord-296347-fanlvxqs	79	6	into	into	IN
cord-296347-fanlvxqs	79	7	the	the	DT
cord-296347-fanlvxqs	79	8	host	host	NN
cord-296347-fanlvxqs	79	9	cell	cell	NN
cord-296347-fanlvxqs	79	10	,	,	,
cord-296347-fanlvxqs	79	11	which	which	WDT
cord-296347-fanlvxqs	79	12	poses	pose	VBZ
cord-296347-fanlvxqs	79	13	great	great	JJ
cord-296347-fanlvxqs	79	14	challenges	challenge	NNS
cord-296347-fanlvxqs	79	15	for	for	IN
cord-296347-fanlvxqs	79	16	avoiding	avoid	VBG
cord-296347-fanlvxqs	79	17	immune	immune	JJ
cord-296347-fanlvxqs	79	18	detection	detection	NN
cord-296347-fanlvxqs	79	19	before	before	IN
cord-296347-fanlvxqs	79	20	establishing	establish	VBG
cord-296347-fanlvxqs	79	21	infection	infection	NN
cord-296347-fanlvxqs	79	22	.	.	.
cord-296347-fanlvxqs	80	1	To	to	TO
cord-296347-fanlvxqs	80	2	promote	promote	VB
cord-296347-fanlvxqs	80	3	entry	entry	NN
cord-296347-fanlvxqs	80	4	into	into	IN
cord-296347-fanlvxqs	80	5	host	host	NN
cord-296347-fanlvxqs	80	6	cells	cell	NNS
cord-296347-fanlvxqs	80	7	without	without	IN
cord-296347-fanlvxqs	80	8	alerting	alert	VBG
cord-296347-fanlvxqs	80	9	the	the	DT
cord-296347-fanlvxqs	80	10	immune	immune	JJ
cord-296347-fanlvxqs	80	11	system	system	NN
cord-296347-fanlvxqs	80	12	,	,	,
cord-296347-fanlvxqs	80	13	bacteria	bacteria	NNS
cord-296347-fanlvxqs	80	14	possess	possess	VBP
cord-296347-fanlvxqs	80	15	capsular	capsular	JJ
cord-296347-fanlvxqs	80	16	surfaces	surface	NNS
cord-296347-fanlvxqs	80	17	that	that	WDT
cord-296347-fanlvxqs	80	18	have	have	VBP
cord-296347-fanlvxqs	80	19	evolved	evolve	VBN
cord-296347-fanlvxqs	80	20	to	to	TO
cord-296347-fanlvxqs	80	21	minimize	minimize	VB
cord-296347-fanlvxqs	80	22	antibody	antibody	NN
cord-296347-fanlvxqs	80	23	and	and	CC
cord-296347-fanlvxqs	80	24	complement	complement	VB
cord-296347-fanlvxqs	80	25	deposition	deposition	NN
cord-296347-fanlvxqs	80	26	while	while	IN
cord-296347-fanlvxqs	80	27	in	in	IN
cord-296347-fanlvxqs	80	28	circulation	circulation	NN
cord-296347-fanlvxqs	80	29	through	through	IN
cord-296347-fanlvxqs	80	30	the	the	DT
cord-296347-fanlvxqs	80	31	body	body	NN
cord-296347-fanlvxqs	80	32	.	.	.
cord-296347-fanlvxqs	81	1	On	on	IN
cord-296347-fanlvxqs	81	2	the	the	DT
cord-296347-fanlvxqs	81	3	other	other	JJ
cord-296347-fanlvxqs	81	4	hand	hand	NN
cord-296347-fanlvxqs	81	5	,	,	,
cord-296347-fanlvxqs	81	6	filamentous	filamentous	JJ
cord-296347-fanlvxqs	81	7	adhesins	adhesin	NNS
cord-296347-fanlvxqs	81	8	(	(	-LRB-
cord-296347-fanlvxqs	81	9	like	like	IN
cord-296347-fanlvxqs	81	10	fimbriae	fimbriae	NNP
cord-296347-fanlvxqs	81	11	and	and	CC
cord-296347-fanlvxqs	81	12	pili	pili	NNP
cord-296347-fanlvxqs	81	13	)	)	-RRB-
cord-296347-fanlvxqs	81	14	that	that	WDT
cord-296347-fanlvxqs	81	15	protrude	protrude	VBP
cord-296347-fanlvxqs	81	16	through	through	IN
cord-296347-fanlvxqs	81	17	the	the	DT
cord-296347-fanlvxqs	81	18	bacteria	bacteria	NNS
cord-296347-fanlvxqs	81	19	's	's	POS
cord-296347-fanlvxqs	81	20	capsule	capsule	NN
cord-296347-fanlvxqs	81	21	enable	enable	VBP
cord-296347-fanlvxqs	81	22	binding	bind	VBG
cord-296347-fanlvxqs	81	23	to	to	TO
cord-296347-fanlvxqs	81	24	host	host	VB
cord-296347-fanlvxqs	81	25	cell	cell	NN
cord-296347-fanlvxqs	81	26	receptors	receptor	NNS
cord-296347-fanlvxqs	81	27	,	,	,
cord-296347-fanlvxqs	81	28	which	which	WDT
cord-296347-fanlvxqs	81	29	enables	enable	VBZ
cord-296347-fanlvxqs	81	30	secretion	secretion	NN
cord-296347-fanlvxqs	81	31	systems	system	NNS
cord-296347-fanlvxqs	81	32	to	to	TO
cord-296347-fanlvxqs	81	33	deliver	deliver	VB
cord-296347-fanlvxqs	81	34	bacterial	bacterial	JJ
cord-296347-fanlvxqs	81	35	effectors	effector	NNS
cord-296347-fanlvxqs	81	36	to	to	TO
cord-296347-fanlvxqs	81	37	modulate	modulate	VB
cord-296347-fanlvxqs	81	38	uptake	uptake	NN
cord-296347-fanlvxqs	81	39	and	and	CC
cord-296347-fanlvxqs	81	40	invasion	invasion	NN
cord-296347-fanlvxqs	81	41	(	(	-LRB-
cord-296347-fanlvxqs	81	42	Finlay	Finlay	NNP
cord-296347-fanlvxqs	81	43	and	and	CC
cord-296347-fanlvxqs	81	44	McFadden	McFadden	NNP
cord-296347-fanlvxqs	81	45	,	,	,
cord-296347-fanlvxqs	81	46	2006	2006	CD
cord-296347-fanlvxqs	81	47	;	;	.
cord-296347-fanlvxqs	82	1	Galan	Galan	NNP
cord-296347-fanlvxqs	82	2	and	and	CC
cord-296347-fanlvxqs	82	3	Collmer	Collmer	NNP
cord-296347-fanlvxqs	82	4	,	,	,
cord-296347-fanlvxqs	82	5	1999	1999	CD
cord-296347-fanlvxqs	82	6	)	)	-RRB-
cord-296347-fanlvxqs	82	7	.	.	.
cord-296347-fanlvxqs	83	1	Virus	virus	NN
cord-296347-fanlvxqs	83	2	particles	particle	NNS
cord-296347-fanlvxqs	83	3	are	be	VBP
cord-296347-fanlvxqs	83	4	very	very	RB
cord-296347-fanlvxqs	83	5	often	often	RB
cord-296347-fanlvxqs	83	6	coated	coat	VBN
cord-296347-fanlvxqs	83	7	with	with	IN
cord-296347-fanlvxqs	83	8	highly	highly	RB
cord-296347-fanlvxqs	83	9	variable	variable	JJ
cord-296347-fanlvxqs	83	10	capsid	capsid	NN
cord-296347-fanlvxqs	83	11	(	(	-LRB-
cord-296347-fanlvxqs	83	12	nonenveloped	nonenveloped	JJ
cord-296347-fanlvxqs	83	13	viruses	virus	NNS
cord-296347-fanlvxqs	83	14	)	)	-RRB-
cord-296347-fanlvxqs	83	15	or	or	CC
cord-296347-fanlvxqs	83	16	envelope	envelope	NN
cord-296347-fanlvxqs	83	17	(	(	-LRB-
cord-296347-fanlvxqs	83	18	enveloped	envelop	VBN
cord-296347-fanlvxqs	83	19	viruses	virus	NNS
cord-296347-fanlvxqs	83	20	)	)	-RRB-
cord-296347-fanlvxqs	83	21	proteins	protein	NNS
cord-296347-fanlvxqs	83	22	to	to	TO
cord-296347-fanlvxqs	83	23	avoid	avoid	VB
cord-296347-fanlvxqs	83	24	detection	detection	NN
cord-296347-fanlvxqs	83	25	and	and	CC
cord-296347-fanlvxqs	83	26	clearance	clearance	NN
cord-296347-fanlvxqs	83	27	by	by	IN
cord-296347-fanlvxqs	83	28	antibody	antibody	NN
cord-296347-fanlvxqs	83	29	-	-	HYPH
cord-296347-fanlvxqs	83	30	mediated	mediate	VBN
cord-296347-fanlvxqs	83	31	responses	response	NNS
cord-296347-fanlvxqs	83	32	.	.	.
cord-296347-fanlvxqs	84	1	These	these	DT
cord-296347-fanlvxqs	84	2	capsids	capsid	NNS
cord-296347-fanlvxqs	84	3	or	or	CC
cord-296347-fanlvxqs	84	4	envelopes	envelope	NNS
cord-296347-fanlvxqs	84	5	can	can	MD
cord-296347-fanlvxqs	84	6	also	also	RB
cord-296347-fanlvxqs	84	7	be	be	VB
cord-296347-fanlvxqs	84	8	studded	stud	VBN
cord-296347-fanlvxqs	84	9	with	with	IN
cord-296347-fanlvxqs	84	10	immunomodulatory	immunomodulatory	JJ
cord-296347-fanlvxqs	84	11	molecules	molecule	NNS
cord-296347-fanlvxqs	84	12	of	of	IN
cord-296347-fanlvxqs	84	13	viral	viral	JJ
cord-296347-fanlvxqs	84	14	or	or	CC
cord-296347-fanlvxqs	84	15	even	even	RB
cord-296347-fanlvxqs	84	16	host	host	NN
cord-296347-fanlvxqs	84	17	origin	origin	NN
cord-296347-fanlvxqs	84	18	and	and	CC
cord-296347-fanlvxqs	84	19	promote	promote	VB
cord-296347-fanlvxqs	84	20	attachment	attachment	NN
cord-296347-fanlvxqs	84	21	to	to	IN
cord-296347-fanlvxqs	84	22	the	the	DT
cord-296347-fanlvxqs	84	23	host	host	NN
cord-296347-fanlvxqs	84	24	cell	cell	NN
cord-296347-fanlvxqs	84	25	membrane	membrane	NN
cord-296347-fanlvxqs	84	26	,	,	,
cord-296347-fanlvxqs	84	27	fusion	fusion	NN
cord-296347-fanlvxqs	84	28	and	and	CC
cord-296347-fanlvxqs	84	29	delivery	delivery	NN
cord-296347-fanlvxqs	84	30	of	of	IN
cord-296347-fanlvxqs	84	31	the	the	DT
cord-296347-fanlvxqs	84	32	virus	virus	NN
cord-296347-fanlvxqs	84	33	internal	internal	JJ
cord-296347-fanlvxqs	84	34	core	core	NN
cord-296347-fanlvxqs	84	35	.	.	.
cord-296347-fanlvxqs	85	1	Alternatively	alternatively	RB
cord-296347-fanlvxqs	85	2	,	,	,
cord-296347-fanlvxqs	85	3	they	-PRON-	PRP
cord-296347-fanlvxqs	85	4	may	may	MD
cord-296347-fanlvxqs	85	5	act	act	VB
cord-296347-fanlvxqs	85	6	as	as	IN
cord-296347-fanlvxqs	85	7	signaling	signal	VBG
cord-296347-fanlvxqs	85	8	devices	device	NNS
cord-296347-fanlvxqs	85	9	and	and	CC
cord-296347-fanlvxqs	85	10	induce	induce	VB
cord-296347-fanlvxqs	85	11	intracellular	intracellular	JJ
cord-296347-fanlvxqs	85	12	cascades	cascade	NNS
cord-296347-fanlvxqs	85	13	required	require	VBN
cord-296347-fanlvxqs	85	14	for	for	IN
cord-296347-fanlvxqs	85	15	virus	virus	NN
cord-296347-fanlvxqs	85	16	uptake	uptake	NN
cord-296347-fanlvxqs	85	17	.	.	.
cord-296347-fanlvxqs	86	1	Ultimately	ultimately	RB
cord-296347-fanlvxqs	86	2	,	,	,
cord-296347-fanlvxqs	86	3	intracellular	intracellular	JJ
cord-296347-fanlvxqs	86	4	release	release	NN
cord-296347-fanlvxqs	86	5	of	of	IN
cord-296347-fanlvxqs	86	6	the	the	DT
cord-296347-fanlvxqs	86	7	viral	viral	JJ
cord-296347-fanlvxqs	86	8	DNA	DNA	NNP
cord-296347-fanlvxqs	86	9	or	or	CC
cord-296347-fanlvxqs	86	10	RNA	RNA	NNP
cord-296347-fanlvxqs	86	11	occurs	occur	VBZ
cord-296347-fanlvxqs	86	12	(	(	-LRB-
cord-296347-fanlvxqs	86	13	Marsh	Marsh	NNP
cord-296347-fanlvxqs	86	14	and	and	CC
cord-296347-fanlvxqs	86	15	Helenius	Helenius	NNP
cord-296347-fanlvxqs	86	16	,	,	,
cord-296347-fanlvxqs	86	17	2006	2006	CD
cord-296347-fanlvxqs	86	18	;	;	:
cord-296347-fanlvxqs	86	19	Skehel	Skehel	NNP
cord-296347-fanlvxqs	86	20	and	and	CC
cord-296347-fanlvxqs	86	21	Wiley	Wiley	NNP
cord-296347-fanlvxqs	86	22	,	,	,
cord-296347-fanlvxqs	86	23	2000	2000	CD
cord-296347-fanlvxqs	86	24	)	)	-RRB-
cord-296347-fanlvxqs	86	25	.	.	.
cord-296347-fanlvxqs	87	1	The	the	DT
cord-296347-fanlvxqs	87	2	establishment	establishment	NN
cord-296347-fanlvxqs	87	3	of	of	IN
cord-296347-fanlvxqs	87	4	an	an	DT
cord-296347-fanlvxqs	87	5	infection	infection	NN
cord-296347-fanlvxqs	87	6	critically	critically	RB
cord-296347-fanlvxqs	87	7	depends	depend	VBZ
cord-296347-fanlvxqs	87	8	on	on	IN
cord-296347-fanlvxqs	87	9	bacterial	bacterial	JJ
cord-296347-fanlvxqs	87	10	and	and	CC
cord-296347-fanlvxqs	87	11	viral	viral	JJ
cord-296347-fanlvxqs	87	12	genes	gene	NNS
cord-296347-fanlvxqs	87	13	dedicated	dedicate	VBN
cord-296347-fanlvxqs	87	14	to	to	IN
cord-296347-fanlvxqs	87	15	manipulation	manipulation	NN
cord-296347-fanlvxqs	87	16	of	of	IN
cord-296347-fanlvxqs	87	17	host	host	NN
cord-296347-fanlvxqs	87	18	functions	function	NNS
cord-296347-fanlvxqs	87	19	.	.	.
cord-296347-fanlvxqs	88	1	A	a	DT
cord-296347-fanlvxqs	88	2	number	number	NN
cord-296347-fanlvxqs	88	3	of	of	IN
cord-296347-fanlvxqs	88	4	reviews	review	NNS
cord-296347-fanlvxqs	88	5	have	have	VBP
cord-296347-fanlvxqs	88	6	covered	cover	VBN
cord-296347-fanlvxqs	88	7	the	the	DT
cord-296347-fanlvxqs	88	8	bacterial	bacterial	JJ
cord-296347-fanlvxqs	88	9	and	and	CC
cord-296347-fanlvxqs	88	10	viral	viral	JJ
cord-296347-fanlvxqs	88	11	genes	gene	NNS
cord-296347-fanlvxqs	88	12	involved	involve	VBN
cord-296347-fanlvxqs	88	13	in	in	IN
cord-296347-fanlvxqs	88	14	manipulation	manipulation	NN
cord-296347-fanlvxqs	88	15	of	of	IN
cord-296347-fanlvxqs	88	16	the	the	DT
cord-296347-fanlvxqs	88	17	host	host	NN
cord-296347-fanlvxqs	88	18	immune	immune	JJ
cord-296347-fanlvxqs	88	19	system	system	NN
cord-296347-fanlvxqs	88	20	,	,	,
cord-296347-fanlvxqs	88	21	from	from	IN
cord-296347-fanlvxqs	88	22	control	control	NN
cord-296347-fanlvxqs	88	23	of	of	IN
cord-296347-fanlvxqs	88	24	apoptosis	apoptosis	NN
cord-296347-fanlvxqs	88	25	,	,	,
cord-296347-fanlvxqs	88	26	cytokine	cytokine	NN
cord-296347-fanlvxqs	88	27	signaling	signaling	NN
cord-296347-fanlvxqs	88	28	,	,	,
cord-296347-fanlvxqs	88	29	to	to	IN
cord-296347-fanlvxqs	88	30	the	the	DT
cord-296347-fanlvxqs	88	31	antibody	antibody	NN
cord-296347-fanlvxqs	88	32	response	response	NN
cord-296347-fanlvxqs	88	33	,	,	,
cord-296347-fanlvxqs	88	34	so	so	CC
cord-296347-fanlvxqs	88	35	the	the	DT
cord-296347-fanlvxqs	88	36	reader	reader	NN
cord-296347-fanlvxqs	88	37	is	be	VBZ
cord-296347-fanlvxqs	88	38	referred	refer	VBN
cord-296347-fanlvxqs	88	39	to	to	IN
cord-296347-fanlvxqs	88	40	Alcami	Alcami	NNP
cord-296347-fanlvxqs	88	41	(	(	-LRB-
cord-296347-fanlvxqs	88	42	2003	2003	CD
cord-296347-fanlvxqs	88	43	)	)	-RRB-
cord-296347-fanlvxqs	88	44	;	;	:
cord-296347-fanlvxqs	88	45	Alcami	Alcami	NNP
cord-296347-fanlvxqs	88	46	and	and	CC
cord-296347-fanlvxqs	88	47	Koszinowski	Koszinowski	NNP
cord-296347-fanlvxqs	88	48	(	(	-LRB-
cord-296347-fanlvxqs	88	49	2000	2000	CD
cord-296347-fanlvxqs	88	50	)	)	-RRB-
cord-296347-fanlvxqs	88	51	;	;	:
cord-296347-fanlvxqs	88	52	Bowie	Bowie	NNP
cord-296347-fanlvxqs	88	53	et	et	NNP
cord-296347-fanlvxqs	88	54	al	al	NNP
cord-296347-fanlvxqs	88	55	.	.	.
cord-296347-fanlvxqs	89	1	(	(	-LRB-
cord-296347-fanlvxqs	89	2	2004	2004	CD
cord-296347-fanlvxqs	89	3	)	)	-RRB-
cord-296347-fanlvxqs	89	4	;	;	:
cord-296347-fanlvxqs	89	5	Finlay	Finlay	NNP
cord-296347-fanlvxqs	89	6	and	and	CC
cord-296347-fanlvxqs	89	7	McFadden	McFadden	NNP
cord-296347-fanlvxqs	89	8	(	(	-LRB-
cord-296347-fanlvxqs	89	9	2006	2006	CD
cord-296347-fanlvxqs	89	10	)	)	-RRB-
cord-296347-fanlvxqs	89	11	;	;	:
cord-296347-fanlvxqs	89	12	Hengel	Hengel	NNP
cord-296347-fanlvxqs	89	13	et	et	NNP
cord-296347-fanlvxqs	89	14	al	al	NNP
cord-296347-fanlvxqs	89	15	.	.	.
cord-296347-fanlvxqs	90	1	(	(	-LRB-
cord-296347-fanlvxqs	90	2	2005	2005	CD
cord-296347-fanlvxqs	90	3	)	)	-RRB-
cord-296347-fanlvxqs	90	4	;	;	:
cord-296347-fanlvxqs	90	5	Hilleman	Hilleman	NNP
cord-296347-fanlvxqs	90	6	(	(	-LRB-
cord-296347-fanlvxqs	90	7	2004	2004	CD
cord-296347-fanlvxqs	90	8	)	)	-RRB-
cord-296347-fanlvxqs	90	9	;	;	:
cord-296347-fanlvxqs	90	10	and	and	CC
cord-296347-fanlvxqs	90	11	Tortorella	Tortorella	NNP
cord-296347-fanlvxqs	90	12	et	et	NNP
cord-296347-fanlvxqs	90	13	al	al	NNP
cord-296347-fanlvxqs	90	14	.	.	.
cord-296347-fanlvxqs	91	1	(	(	-LRB-
cord-296347-fanlvxqs	91	2	2000	2000	CD
cord-296347-fanlvxqs	91	3	)	)	-RRB-
cord-296347-fanlvxqs	91	4	.	.	.
cord-296347-fanlvxqs	92	1	For	for	IN
cord-296347-fanlvxqs	92	2	the	the	DT
cord-296347-fanlvxqs	92	3	purpose	purpose	NN
cord-296347-fanlvxqs	92	4	of	of	IN
cord-296347-fanlvxqs	92	5	this	this	DT
cord-296347-fanlvxqs	92	6	chapter	chapter	NN
cord-296347-fanlvxqs	92	7	,	,	,
cord-296347-fanlvxqs	92	8	we	-PRON-	PRP
cord-296347-fanlvxqs	92	9	will	will	MD
cord-296347-fanlvxqs	92	10	focus	focus	VB
cord-296347-fanlvxqs	92	11	on	on	IN
cord-296347-fanlvxqs	92	12	pathogen	pathogen	NN
cord-296347-fanlvxqs	92	13	manipulation	manipulation	NN
cord-296347-fanlvxqs	92	14	of	of	IN
cord-296347-fanlvxqs	92	15	antigen	antigen	NN
cord-296347-fanlvxqs	92	16	presentation	presentation	NN
cord-296347-fanlvxqs	92	17	pathways	pathway	NNS
cord-296347-fanlvxqs	92	18	and	and	CC
cord-296347-fanlvxqs	92	19	the	the	DT
cord-296347-fanlvxqs	92	20	Ub	Ub	NNP
cord-296347-fanlvxqs	92	21	-	-	HYPH
cord-296347-fanlvxqs	92	22	proteasome	proteasome	NN
cord-296347-fanlvxqs	92	23	system	system	NN
cord-296347-fanlvxqs	92	24	.	.	.
cord-296347-fanlvxqs	93	1	Antigen	antigen	NN
cord-296347-fanlvxqs	93	2	presentation	presentation	NN
cord-296347-fanlvxqs	93	3	involves	involve	VBZ
cord-296347-fanlvxqs	93	4	the	the	DT
cord-296347-fanlvxqs	93	5	conversion	conversion	NN
cord-296347-fanlvxqs	93	6	of	of	IN
cord-296347-fanlvxqs	93	7	protein	protein	NN
cord-296347-fanlvxqs	93	8	antigens	antigen	NNS
cord-296347-fanlvxqs	93	9	into	into	IN
cord-296347-fanlvxqs	93	10	peptide	peptide	NN
cord-296347-fanlvxqs	93	11	ligands	ligand	NNS
cord-296347-fanlvxqs	93	12	that	that	WDT
cord-296347-fanlvxqs	93	13	can	can	MD
cord-296347-fanlvxqs	93	14	bind	bind	VB
cord-296347-fanlvxqs	93	15	to	to	IN
cord-296347-fanlvxqs	93	16	MHC	MHC	NNP
cord-296347-fanlvxqs	93	17	products	product	NNS
cord-296347-fanlvxqs	93	18	that	that	WDT
cord-296347-fanlvxqs	93	19	are	be	VBP
cord-296347-fanlvxqs	93	20	displayed	display	VBN
cord-296347-fanlvxqs	93	21	at	at	IN
cord-296347-fanlvxqs	93	22	the	the	DT
cord-296347-fanlvxqs	93	23	cell	cell	NN
cord-296347-fanlvxqs	93	24	surface	surface	NN
cord-296347-fanlvxqs	93	25	for	for	IN
cord-296347-fanlvxqs	93	26	recognition	recognition	NN
cord-296347-fanlvxqs	93	27	by	by	IN
cord-296347-fanlvxqs	93	28	T	T	NNP
cord-296347-fanlvxqs	93	29	cells	cell	NNS
cord-296347-fanlvxqs	93	30	.	.	.
cord-296347-fanlvxqs	94	1	In	in	IN
cord-296347-fanlvxqs	94	2	a	a	DT
cord-296347-fanlvxqs	94	3	simplified	simplified	JJ
cord-296347-fanlvxqs	94	4	view	view	NN
cord-296347-fanlvxqs	94	5	of	of	IN
cord-296347-fanlvxqs	94	6	antigen	antigen	NN
cord-296347-fanlvxqs	94	7	presentation	presentation	NN
cord-296347-fanlvxqs	94	8	,	,	,
cord-296347-fanlvxqs	94	9	the	the	DT
cord-296347-fanlvxqs	94	10	class	class	NN
cord-296347-fanlvxqs	94	11	I	i	NN
cord-296347-fanlvxqs	94	12	and	and	CC
cord-296347-fanlvxqs	94	13	class	class	NN
cord-296347-fanlvxqs	94	14	II	II	NNP
cord-296347-fanlvxqs	94	15	MHC	MHC	NNP
cord-296347-fanlvxqs	94	16	pathways	pathway	NNS
cord-296347-fanlvxqs	94	17	have	have	VBP
cord-296347-fanlvxqs	94	18	evolved	evolve	VBN
cord-296347-fanlvxqs	94	19	to	to	TO
cord-296347-fanlvxqs	94	20	sample	sample	VB
cord-296347-fanlvxqs	94	21	different	different	JJ
cord-296347-fanlvxqs	94	22	sources	source	NNS
cord-296347-fanlvxqs	94	23	of	of	IN
cord-296347-fanlvxqs	94	24	antigen	antigen	NN
cord-296347-fanlvxqs	94	25	to	to	TO
cord-296347-fanlvxqs	94	26	which	which	WDT
cord-296347-fanlvxqs	94	27	they	-PRON-	PRP
cord-296347-fanlvxqs	94	28	have	have	VBP
cord-296347-fanlvxqs	94	29	access	access	NN
cord-296347-fanlvxqs	94	30	:	:	:
cord-296347-fanlvxqs	94	31	the	the	DT
cord-296347-fanlvxqs	94	32	class	class	NN
cord-296347-fanlvxqs	94	33	I	-PRON-	PRP
cord-296347-fanlvxqs	94	34	MHC	MHC	NNP
cord-296347-fanlvxqs	94	35	pathway	pathway	NN
cord-296347-fanlvxqs	94	36	usually	usually	RB
cord-296347-fanlvxqs	94	37	deals	deal	VBZ
cord-296347-fanlvxqs	94	38	with	with	IN
cord-296347-fanlvxqs	94	39	cytosolic	cytosolic	JJ
cord-296347-fanlvxqs	94	40	antigens	antigen	NNS
cord-296347-fanlvxqs	94	41	and	and	CC
cord-296347-fanlvxqs	94	42	is	be	VBZ
cord-296347-fanlvxqs	94	43	crucial	crucial	JJ
cord-296347-fanlvxqs	94	44	for	for	IN
cord-296347-fanlvxqs	94	45	activation	activation	NN
cord-296347-fanlvxqs	94	46	of	of	IN
cord-296347-fanlvxqs	94	47	CD8	CD8	NNP
cord-296347-fanlvxqs	94	48	þ	þ	NNP
cord-296347-fanlvxqs	94	49	T	T	NNP
cord-296347-fanlvxqs	94	50	cells	cell	NNS
cord-296347-fanlvxqs	94	51	,	,	,
cord-296347-fanlvxqs	94	52	whereas	whereas	IN
cord-296347-fanlvxqs	94	53	the	the	DT
cord-296347-fanlvxqs	94	54	class	class	NN
cord-296347-fanlvxqs	94	55	II	II	NNP
cord-296347-fanlvxqs	94	56	MHC	MHC	NNP
cord-296347-fanlvxqs	94	57	pathway	pathway	NN
cord-296347-fanlvxqs	94	58	deals	deal	NNS
cord-296347-fanlvxqs	94	59	with	with	IN
cord-296347-fanlvxqs	94	60	exogenous	exogenous	JJ
cord-296347-fanlvxqs	94	61	antigens	antigen	NNS
cord-296347-fanlvxqs	94	62	and	and	CC
cord-296347-fanlvxqs	94	63	the	the	DT
cord-296347-fanlvxqs	94	64	activation	activation	NN
cord-296347-fanlvxqs	94	65	of	of	IN
cord-296347-fanlvxqs	94	66	CD4	CD4	NNP
cord-296347-fanlvxqs	94	67	þ	þ	NNP
cord-296347-fanlvxqs	94	68	T	t	NN
cord-296347-fanlvxqs	94	69	cells	cell	NNS
cord-296347-fanlvxqs	94	70	(	(	-LRB-
cord-296347-fanlvxqs	94	71	Bryant	Bryant	NNP
cord-296347-fanlvxqs	94	72	and	and	CC
cord-296347-fanlvxqs	94	73	Ploegh	Ploegh	NNP
cord-296347-fanlvxqs	94	74	,	,	,
cord-296347-fanlvxqs	94	75	2004	2004	CD
cord-296347-fanlvxqs	94	76	;	;	:
cord-296347-fanlvxqs	94	77	Cresswell	Cresswell	NNP
cord-296347-fanlvxqs	94	78	et	et	NNP
cord-296347-fanlvxqs	94	79	al	al	NNP
cord-296347-fanlvxqs	94	80	.	.	NNP
cord-296347-fanlvxqs	94	81	,	,	,
cord-296347-fanlvxqs	94	82	2005	2005	CD
cord-296347-fanlvxqs	94	83	;	;	:
cord-296347-fanlvxqs	94	84	Pamer	Pamer	NNP
cord-296347-fanlvxqs	94	85	and	and	CC
cord-296347-fanlvxqs	94	86	Cresswell	Cresswell	NNP
cord-296347-fanlvxqs	94	87	,	,	,
cord-296347-fanlvxqs	94	88	1998	1998	CD
cord-296347-fanlvxqs	94	89	)	)	-RRB-
cord-296347-fanlvxqs	94	90	.	.	.
cord-296347-fanlvxqs	95	1	Antigen	antigen	NN
cord-296347-fanlvxqs	95	2	presentation	presentation	NN
cord-296347-fanlvxqs	95	3	is	be	VBZ
cord-296347-fanlvxqs	95	4	,	,	,
cord-296347-fanlvxqs	95	5	of	of	IN
cord-296347-fanlvxqs	95	6	course	course	NN
cord-296347-fanlvxqs	95	7	,	,	,
cord-296347-fanlvxqs	95	8	not	not	RB
cord-296347-fanlvxqs	95	9	as	as	RB
cord-296347-fanlvxqs	95	10	simple	simple	JJ
cord-296347-fanlvxqs	95	11	and	and	CC
cord-296347-fanlvxqs	95	12	clearcut	clearcut	JJ
cord-296347-fanlvxqs	95	13	,	,	,
cord-296347-fanlvxqs	95	14	as	as	IN
cord-296347-fanlvxqs	95	15	we	-PRON-	PRP
cord-296347-fanlvxqs	95	16	shall	shall	MD
cord-296347-fanlvxqs	95	17	discuss	discuss	VB
cord-296347-fanlvxqs	95	18	later	later	RB
cord-296347-fanlvxqs	95	19	.	.	.
cord-296347-fanlvxqs	96	1	There	there	EX
cord-296347-fanlvxqs	96	2	are	be	VBP
cord-296347-fanlvxqs	96	3	,	,	,
cord-296347-fanlvxqs	96	4	however	however	RB
cord-296347-fanlvxqs	96	5	,	,	,
cord-296347-fanlvxqs	96	6	common	common	JJ
cord-296347-fanlvxqs	96	7	principles	principle	NNS
cord-296347-fanlvxqs	96	8	that	that	WDT
cord-296347-fanlvxqs	96	9	apply	apply	VBP
cord-296347-fanlvxqs	96	10	to	to	IN
cord-296347-fanlvxqs	96	11	the	the	DT
cord-296347-fanlvxqs	96	12	discrete	discrete	JJ
cord-296347-fanlvxqs	96	13	steps	step	NNS
cord-296347-fanlvxqs	96	14	of	of	IN
cord-296347-fanlvxqs	96	15	antigen	antigen	NN
cord-296347-fanlvxqs	96	16	processing	processing	NN
cord-296347-fanlvxqs	96	17	and	and	CC
cord-296347-fanlvxqs	96	18	presentation	presentation	NN
cord-296347-fanlvxqs	96	19	by	by	IN
cord-296347-fanlvxqs	96	20	class	class	NN
cord-296347-fanlvxqs	96	21	I	i	NN
cord-296347-fanlvxqs	96	22	and	and	CC
cord-296347-fanlvxqs	96	23	class	class	NN
cord-296347-fanlvxqs	96	24	II	II	NNP
cord-296347-fanlvxqs	96	25	MHC	MHC	NNP
cord-296347-fanlvxqs	96	26	molecules	molecule	NNS
cord-296347-fanlvxqs	96	27	:	:	:
cord-296347-fanlvxqs	96	28	antigen	antigen	NNP
cord-296347-fanlvxqs	96	29	must	must	MD
cord-296347-fanlvxqs	96	30	be	be	VB
cord-296347-fanlvxqs	96	31	acquired	acquire	VBN
cord-296347-fanlvxqs	96	32	,	,	,
cord-296347-fanlvxqs	96	33	it	-PRON-	PRP
cord-296347-fanlvxqs	96	34	is	be	VBZ
cord-296347-fanlvxqs	96	35	subjected	subject	VBN
cord-296347-fanlvxqs	96	36	to	to	IN
cord-296347-fanlvxqs	96	37	proteolysis	proteolysis	NN
cord-296347-fanlvxqs	96	38	,	,	,
cord-296347-fanlvxqs	96	39	delivered	deliver	VBN
cord-296347-fanlvxqs	96	40	to	to	IN
cord-296347-fanlvxqs	96	41	MHC	MHC	NNP
cord-296347-fanlvxqs	96	42	þ	þ	NNP
cord-296347-fanlvxqs	96	43	compartments	compartment	NNS
cord-296347-fanlvxqs	96	44	,	,	,
cord-296347-fanlvxqs	96	45	and	and	CC
cord-296347-fanlvxqs	96	46	properly	properly	RB
cord-296347-fanlvxqs	96	47	assembled	assemble	VBN
cord-296347-fanlvxqs	96	48	with	with	IN
cord-296347-fanlvxqs	96	49	the	the	DT
cord-296347-fanlvxqs	96	50	MHC	MHC	NNP
cord-296347-fanlvxqs	96	51	product	product	NN
cord-296347-fanlvxqs	96	52	.	.	.
cord-296347-fanlvxqs	97	1	The	the	DT
cord-296347-fanlvxqs	97	2	complex	complex	NN
cord-296347-fanlvxqs	97	3	is	be	VBZ
cord-296347-fanlvxqs	97	4	then	then	RB
cord-296347-fanlvxqs	97	5	subject	subject	JJ
cord-296347-fanlvxqs	97	6	to	to	IN
cord-296347-fanlvxqs	97	7	sorting	sort	VBG
cord-296347-fanlvxqs	97	8	through	through	IN
cord-296347-fanlvxqs	97	9	the	the	DT
cord-296347-fanlvxqs	97	10	secretory	secretory	JJ
cord-296347-fanlvxqs	97	11	pathway	pathway	NN
cord-296347-fanlvxqs	97	12	and	and	CC
cord-296347-fanlvxqs	97	13	delivered	deliver	VBD
cord-296347-fanlvxqs	97	14	to	to	IN
cord-296347-fanlvxqs	97	15	the	the	DT
cord-296347-fanlvxqs	97	16	cell	cell	NN
cord-296347-fanlvxqs	97	17	surface	surface	NN
cord-296347-fanlvxqs	97	18	(	(	-LRB-
cord-296347-fanlvxqs	97	19	Fig	Fig	NNP
cord-296347-fanlvxqs	97	20	.	.	.
cord-296347-fanlvxqs	97	21	1	1	CD
cord-296347-fanlvxqs	97	22	)	)	-RRB-
cord-296347-fanlvxqs	97	23	.	.	.
cord-296347-fanlvxqs	98	1	Because	because	IN
cord-296347-fanlvxqs	98	2	each	each	DT
cord-296347-fanlvxqs	98	3	of	of	IN
cord-296347-fanlvxqs	98	4	these	these	DT
cord-296347-fanlvxqs	98	5	steps	step	NNS
cord-296347-fanlvxqs	98	6	affords	afford	VBZ
cord-296347-fanlvxqs	98	7	a	a	DT
cord-296347-fanlvxqs	98	8	target	target	NN
cord-296347-fanlvxqs	98	9	for	for	IN
cord-296347-fanlvxqs	98	10	interference	interference	NN
cord-296347-fanlvxqs	98	11	by	by	IN
cord-296347-fanlvxqs	98	12	pathogens	pathogen	NNS
cord-296347-fanlvxqs	98	13	,	,	,
cord-296347-fanlvxqs	98	14	we	-PRON-	PRP
cord-296347-fanlvxqs	98	15	shall	shall	MD
cord-296347-fanlvxqs	98	16	survey	survey	VB
cord-296347-fanlvxqs	98	17	them	-PRON-	PRP
cord-296347-fanlvxqs	98	18	for	for	IN
cord-296347-fanlvxqs	98	19	each	each	DT
cord-296347-fanlvxqs	98	20	pathway	pathway	NN
cord-296347-fanlvxqs	98	21	.	.	.
cord-296347-fanlvxqs	99	1	The	the	DT
cord-296347-fanlvxqs	99	2	class	class	NN
cord-296347-fanlvxqs	99	3	I	-PRON-	PRP
cord-296347-fanlvxqs	99	4	MHC	MHC	NNP
cord-296347-fanlvxqs	99	5	is	be	VBZ
cord-296347-fanlvxqs	99	6	a	a	DT
cord-296347-fanlvxqs	99	7	trimeric	trimeric	RB
cord-296347-fanlvxqs	99	8	complex	complex	NN
cord-296347-fanlvxqs	99	9	composed	compose	VBN
cord-296347-fanlvxqs	99	10	of	of	IN
cord-296347-fanlvxqs	99	11	the	the	DT
cord-296347-fanlvxqs	99	12	class	class	NN
cord-296347-fanlvxqs	100	1	I	-PRON-	PRP
cord-296347-fanlvxqs	100	2	MHC	MHC	NNP
cord-296347-fanlvxqs	100	3	heavy	heavy	JJ
cord-296347-fanlvxqs	100	4	chain	chain	NN
cord-296347-fanlvxqs	100	5	(	(	-LRB-
cord-296347-fanlvxqs	100	6	HC	HC	NNP
cord-296347-fanlvxqs	100	7	)	)	-RRB-
cord-296347-fanlvxqs	100	8	,	,	,
cord-296347-fanlvxqs	100	9	the	the	DT
cord-296347-fanlvxqs	100	10	b	b	NN
cord-296347-fanlvxqs	100	11	2	2	CD
cord-296347-fanlvxqs	100	12	-microglobulin	-microglobulin	CD
cord-296347-fanlvxqs	100	13	(	(	-LRB-
cord-296347-fanlvxqs	100	14	b	b	NN
cord-296347-fanlvxqs	100	15	2	2	CD
cord-296347-fanlvxqs	100	16	m	m	CD
cord-296347-fanlvxqs	100	17	)	)	-RRB-
cord-296347-fanlvxqs	100	18	or	or	CC
cord-296347-fanlvxqs	100	19	light	light	JJ
cord-296347-fanlvxqs	100	20	chain	chain	NN
cord-296347-fanlvxqs	100	21	,	,	,
cord-296347-fanlvxqs	100	22	and	and	CC
cord-296347-fanlvxqs	100	23	the	the	DT
cord-296347-fanlvxqs	100	24	antigenic	antigenic	JJ
cord-296347-fanlvxqs	100	25	peptide	peptide	NN
cord-296347-fanlvxqs	100	26	.	.	.
cord-296347-fanlvxqs	101	1	The	the	DT
cord-296347-fanlvxqs	101	2	structure	structure	NN
cord-296347-fanlvxqs	101	3	of	of	IN
cord-296347-fanlvxqs	101	4	the	the	DT
cord-296347-fanlvxqs	101	5	fully	fully	RB
cord-296347-fanlvxqs	101	6	assembled	assemble	VBN
cord-296347-fanlvxqs	101	7	complex	complex	NN
cord-296347-fanlvxqs	101	8	and	and	CC
cord-296347-fanlvxqs	101	9	its	-PRON-	PRP$
cord-296347-fanlvxqs	101	10	interactions	interaction	NNS
cord-296347-fanlvxqs	101	11	with	with	IN
cord-296347-fanlvxqs	101	12	antigen	antigen	NN
cord-296347-fanlvxqs	101	13	-	-	HYPH
cord-296347-fanlvxqs	101	14	specific	specific	JJ
cord-296347-fanlvxqs	101	15	receptors	receptor	NNS
cord-296347-fanlvxqs	101	16	on	on	IN
cord-296347-fanlvxqs	101	17	T	t	NN
cord-296347-fanlvxqs	101	18	cells	cell	NNS
cord-296347-fanlvxqs	101	19	have	have	VBP
cord-296347-fanlvxqs	101	20	been	be	VBN
cord-296347-fanlvxqs	101	21	extensively	extensively	RB
cord-296347-fanlvxqs	101	22	reviewed	review	VBN
cord-296347-fanlvxqs	101	23	(	(	-LRB-
cord-296347-fanlvxqs	101	24	Alam	Alam	NNP
cord-296347-fanlvxqs	101	25	et	et	NNP
cord-296347-fanlvxqs	101	26	al	al	NNP
cord-296347-fanlvxqs	101	27	.	.	NNP
cord-296347-fanlvxqs	101	28	,	,	,
cord-296347-fanlvxqs	101	29	1996	1996	CD
cord-296347-fanlvxqs	101	30	;	;	:
cord-296347-fanlvxqs	101	31	Rudolph	Rudolph	NNP
cord-296347-fanlvxqs	101	32	and	and	CC
cord-296347-fanlvxqs	101	33	Wilson	Wilson	NNP
cord-296347-fanlvxqs	101	34	,	,	,
cord-296347-fanlvxqs	101	35	2002	2002	CD
cord-296347-fanlvxqs	101	36	;	;	:
cord-296347-fanlvxqs	101	37	von	von	NNP
cord-296347-fanlvxqs	101	38	Boehmer	Boehmer	NNP
cord-296347-fanlvxqs	101	39	,	,	,
cord-296347-fanlvxqs	101	40	2006	2006	CD
cord-296347-fanlvxqs	101	41	)	)	-RRB-
cord-296347-fanlvxqs	101	42	.	.	.
cord-296347-fanlvxqs	102	1	The	the	DT
cord-296347-fanlvxqs	102	2	class	class	NN
cord-296347-fanlvxqs	102	3	I	-PRON-	PRP
cord-296347-fanlvxqs	102	4	MHC	MHC	NNP
cord-296347-fanlvxqs	102	5	HC	HC	NNP
cord-296347-fanlvxqs	102	6	is	be	VBZ
cord-296347-fanlvxqs	102	7	inserted	insert	VBN
cord-296347-fanlvxqs	102	8	into	into	IN
cord-296347-fanlvxqs	102	9	the	the	DT
cord-296347-fanlvxqs	102	10	ER	ER	NNP
cord-296347-fanlvxqs	102	11	membrane	membrane	NN
cord-296347-fanlvxqs	102	12	and	and	CC
cord-296347-fanlvxqs	102	13	N	n	CD
cord-296347-fanlvxqs	102	14	-	-	HYPH
cord-296347-fanlvxqs	102	15	glycosylated	glycosylate	VBN
cord-296347-fanlvxqs	102	16	and	and	CC
cord-296347-fanlvxqs	102	17	binds	bind	VBZ
cord-296347-fanlvxqs	102	18	in	in	IN
cord-296347-fanlvxqs	102	19	its	-PRON-	PRP$
cord-296347-fanlvxqs	102	20	course	course	NN
cord-296347-fanlvxqs	102	21	of	of	IN
cord-296347-fanlvxqs	102	22	synthesis	synthesis	NN
cord-296347-fanlvxqs	102	23	to	to	IN
cord-296347-fanlvxqs	102	24	the	the	DT
cord-296347-fanlvxqs	102	25	membrane	membrane	NN
cord-296347-fanlvxqs	102	26	-	-	HYPH
cord-296347-fanlvxqs	102	27	associated	associate	VBN
cord-296347-fanlvxqs	102	28	chaperone	chaperone	NN
cord-296347-fanlvxqs	102	29	calnexin	calnexin	NN
cord-296347-fanlvxqs	102	30	(	(	-LRB-
cord-296347-fanlvxqs	102	31	CNX	CNX	NNP
cord-296347-fanlvxqs	102	32	)	)	-RRB-
cord-296347-fanlvxqs	102	33	,	,	,
cord-296347-fanlvxqs	102	34	at	at	IN
cord-296347-fanlvxqs	102	35	which	which	WDT
cord-296347-fanlvxqs	102	36	point	point	NN
cord-296347-fanlvxqs	102	37	folding	folding	NN
cord-296347-fanlvxqs	102	38	and	and	CC
cord-296347-fanlvxqs	102	39	intrachain	intrachain	NN
cord-296347-fanlvxqs	102	40	disulfide	disulfide	NN
cord-296347-fanlvxqs	102	41	bond	bond	NN
cord-296347-fanlvxqs	102	42	formation	formation	NN
cord-296347-fanlvxqs	102	43	take	take	VB
cord-296347-fanlvxqs	102	44	place	place	NN
cord-296347-fanlvxqs	102	45	.	.	.
cord-296347-fanlvxqs	103	1	Once	once	RB
cord-296347-fanlvxqs	103	2	dissociated	dissociate	VBN
cord-296347-fanlvxqs	103	3	from	from	IN
cord-296347-fanlvxqs	103	4	CNX	CNX	NNP
cord-296347-fanlvxqs	103	5	,	,	,
cord-296347-fanlvxqs	103	6	the	the	DT
cord-296347-fanlvxqs	103	7	HC	HC	NNP
cord-296347-fanlvxqs	103	8	binds	bind	VBZ
cord-296347-fanlvxqs	103	9	its	-PRON-	PRP$
cord-296347-fanlvxqs	103	10	soluble	soluble	JJ
cord-296347-fanlvxqs	103	11	partner	partner	NN
cord-296347-fanlvxqs	103	12	subunit	subunit	NN
cord-296347-fanlvxqs	103	13	,	,	,
cord-296347-fanlvxqs	103	14	b	b	NN
cord-296347-fanlvxqs	103	15	2	2	CD
cord-296347-fanlvxqs	103	16	m	m	NN
cord-296347-fanlvxqs	103	17	,	,	,
cord-296347-fanlvxqs	103	18	and	and	CC
cord-296347-fanlvxqs	103	19	enters	enter	VBZ
cord-296347-fanlvxqs	103	20	the	the	DT
cord-296347-fanlvxqs	103	21	peptide	peptide	NN
cord-296347-fanlvxqs	103	22	-	-	HYPH
cord-296347-fanlvxqs	103	23	loading	loading	NN
cord-296347-fanlvxqs	103	24	complex	complex	NN
cord-296347-fanlvxqs	103	25	(	(	-LRB-
cord-296347-fanlvxqs	103	26	PLC	PLC	NNP
cord-296347-fanlvxqs	103	27	)	)	-RRB-
cord-296347-fanlvxqs	103	28	.	.	.
cord-296347-fanlvxqs	104	1	The	the	DT
cord-296347-fanlvxqs	104	2	PLC	PLC	NNP
cord-296347-fanlvxqs	104	3	is	be	VBZ
cord-296347-fanlvxqs	104	4	composed	compose	VBN
cord-296347-fanlvxqs	104	5	of	of	IN
cord-296347-fanlvxqs	104	6	two	two	CD
cord-296347-fanlvxqs	104	7	MHC	MHC	NNP
cord-296347-fanlvxqs	104	8	-	-	HYPH
cord-296347-fanlvxqs	104	9	encoded	encode	VBN
cord-296347-fanlvxqs	104	10	components	component	NNS
cord-296347-fanlvxqs	104	11	,	,	,
cord-296347-fanlvxqs	104	12	TAP	tap	NN
cord-296347-fanlvxqs	104	13	and	and	CC
cord-296347-fanlvxqs	104	14	tapasin	tapasin	NNP
cord-296347-fanlvxqs	104	15	,	,	,
cord-296347-fanlvxqs	104	16	and	and	CC
cord-296347-fanlvxqs	104	17	two	two	CD
cord-296347-fanlvxqs	104	18	'	'	''
cord-296347-fanlvxqs	104	19	'	'	``
cord-296347-fanlvxqs	104	20	housekeeping	housekeeping	NN
cord-296347-fanlvxqs	104	21	'	'	''
cord-296347-fanlvxqs	104	22	'	'	''
cord-296347-fanlvxqs	104	23	ER	ER	NNP
cord-296347-fanlvxqs	104	24	proteins	protein	NNS
cord-296347-fanlvxqs	104	25	,	,	,
cord-296347-fanlvxqs	104	26	calreticulin	calreticulin	NNP
cord-296347-fanlvxqs	104	27	and	and	CC
cord-296347-fanlvxqs	104	28	ERp57	ERp57	NNS
cord-296347-fanlvxqs	104	29	.	.	.
cord-296347-fanlvxqs	105	1	The	the	DT
cord-296347-fanlvxqs	105	2	transporter	transporter	NN
cord-296347-fanlvxqs	105	3	associated	associate	VBN
cord-296347-fanlvxqs	105	4	with	with	IN
cord-296347-fanlvxqs	105	5	antigen	antigen	NN
cord-296347-fanlvxqs	105	6	presentation	presentation	NN
cord-296347-fanlvxqs	105	7	(	(	-LRB-
cord-296347-fanlvxqs	105	8	TAP	tap	NN
cord-296347-fanlvxqs	105	9	)	)	-RRB-
cord-296347-fanlvxqs	105	10	is	be	VBZ
cord-296347-fanlvxqs	105	11	an	an	DT
cord-296347-fanlvxqs	105	12	ATP	ATP	NNP
cord-296347-fanlvxqs	105	13	-	-	HYPH
cord-296347-fanlvxqs	105	14	dependent	dependent	JJ
cord-296347-fanlvxqs	105	15	pump	pump	NN
cord-296347-fanlvxqs	105	16	with	with	IN
cord-296347-fanlvxqs	105	17	two	two	CD
cord-296347-fanlvxqs	105	18	subunits	subunit	NNS
cord-296347-fanlvxqs	105	19	,	,	,
cord-296347-fanlvxqs	105	20	TAP1	TAP1	NNP
cord-296347-fanlvxqs	105	21	and	and	CC
cord-296347-fanlvxqs	105	22	TAP2	TAP2	NNP
cord-296347-fanlvxqs	105	23	that	that	WDT
cord-296347-fanlvxqs	105	24	transports	transport	VBZ
cord-296347-fanlvxqs	105	25	peptides	peptide	NNS
cord-296347-fanlvxqs	105	26	into	into	IN
cord-296347-fanlvxqs	105	27	the	the	DT
cord-296347-fanlvxqs	105	28	ER	er	NN
cord-296347-fanlvxqs	105	29	.	.	.
cord-296347-fanlvxqs	106	1	Tapasin	Tapasin	NNP
cord-296347-fanlvxqs	106	2	,	,	,
cord-296347-fanlvxqs	106	3	a	a	DT
cord-296347-fanlvxqs	106	4	transmembrane	transmembrane	NN
cord-296347-fanlvxqs	106	5	glycoprotein	glycoprotein	NN
cord-296347-fanlvxqs	106	6	,	,	,
cord-296347-fanlvxqs	106	7	mediates	mediate	VBZ
cord-296347-fanlvxqs	106	8	the	the	DT
cord-296347-fanlvxqs	106	9	interaction	interaction	NN
cord-296347-fanlvxqs	106	10	between	between	IN
cord-296347-fanlvxqs	106	11	the	the	DT
cord-296347-fanlvxqs	106	12	TAP	TAP	NNP
cord-296347-fanlvxqs	106	13	transporter	transporter	NN
cord-296347-fanlvxqs	106	14	and	and	CC
cord-296347-fanlvxqs	106	15	peptide	peptide	NN
cord-296347-fanlvxqs	106	16	-	-	HYPH
cord-296347-fanlvxqs	106	17	free	free	JJ
cord-296347-fanlvxqs	106	18	HC	HC	NNP
cord-296347-fanlvxqs	106	19	/	/	SYM
cord-296347-fanlvxqs	106	20	b	b	NN
cord-296347-fanlvxqs	106	21	2	2	CD
cord-296347-fanlvxqs	106	22	m	m	NN
cord-296347-fanlvxqs	106	23	dimers	dimer	NNS
cord-296347-fanlvxqs	106	24	.	.	.
cord-296347-fanlvxqs	107	1	The	the	DT
cord-296347-fanlvxqs	107	2	soluble	soluble	JJ
cord-296347-fanlvxqs	107	3	calreticulin	calreticulin	NN
cord-296347-fanlvxqs	107	4	and	and	CC
cord-296347-fanlvxqs	107	5	ERp57	ERp57	NNS
cord-296347-fanlvxqs	107	6	,	,	,
cord-296347-fanlvxqs	107	7	a	a	DT
cord-296347-fanlvxqs	107	8	chaperone	chaperone	NN
cord-296347-fanlvxqs	107	9	and	and	CC
cord-296347-fanlvxqs	107	10	a	a	DT
cord-296347-fanlvxqs	107	11	thiol	thiol	NN
cord-296347-fanlvxqs	107	12	oxidoreductase	oxidoreductase	NN
cord-296347-fanlvxqs	107	13	,	,	,
cord-296347-fanlvxqs	107	14	respectively	respectively	RB
cord-296347-fanlvxqs	107	15	,	,	,
cord-296347-fanlvxqs	107	16	normally	normally	RB
cord-296347-fanlvxqs	107	17	involved	involve	VBN
cord-296347-fanlvxqs	107	18	in	in	IN
cord-296347-fanlvxqs	107	19	folding	folding	NN
cord-296347-fanlvxqs	107	20	of	of	IN
cord-296347-fanlvxqs	107	21	nascent	nascent	JJ
cord-296347-fanlvxqs	107	22	glycoproteins	glycoprotein	NNS
cord-296347-fanlvxqs	107	23	,	,	,
cord-296347-fanlvxqs	107	24	promote	promote	VB
cord-296347-fanlvxqs	107	25	assembly	assembly	NN
cord-296347-fanlvxqs	107	26	of	of	IN
cord-296347-fanlvxqs	107	27	the	the	DT
cord-296347-fanlvxqs	107	28	class	class	NN
cord-296347-fanlvxqs	107	29	I	-PRON-	PRP
cord-296347-fanlvxqs	107	30	MHC	MHC	NNP
cord-296347-fanlvxqs	107	31	complex	complex	NN
cord-296347-fanlvxqs	107	32	.	.	.
cord-296347-fanlvxqs	108	1	The	the	DT
cord-296347-fanlvxqs	108	2	peptide	peptide	JJ
cord-296347-fanlvxqs	108	3	antigen	antigen	NN
cord-296347-fanlvxqs	108	4	cargo	cargo	NN
cord-296347-fanlvxqs	108	5	for	for	IN
cord-296347-fanlvxqs	108	6	class	class	NN
cord-296347-fanlvxqs	108	7	I	-PRON-	PRP
cord-296347-fanlvxqs	108	8	MHC	MHC	NNP
cord-296347-fanlvxqs	108	9	originates	originate	VBZ
cord-296347-fanlvxqs	108	10	from	from	IN
cord-296347-fanlvxqs	108	11	proteasomal	proteasomal	JJ
cord-296347-fanlvxqs	108	12	proteolysis	proteolysis	NN
cord-296347-fanlvxqs	108	13	in	in	IN
cord-296347-fanlvxqs	108	14	the	the	DT
cord-296347-fanlvxqs	108	15	cytosol	cytosol	NN
cord-296347-fanlvxqs	108	16	.	.	.
cord-296347-fanlvxqs	109	1	The	the	DT
cord-296347-fanlvxqs	109	2	array	array	NN
cord-296347-fanlvxqs	109	3	of	of	IN
cord-296347-fanlvxqs	109	4	proteasome	proteasome	NN
cord-296347-fanlvxqs	109	5	-	-	HYPH
cord-296347-fanlvxqs	109	6	generated	generate	VBN
cord-296347-fanlvxqs	109	7	peptides	peptide	NNS
cord-296347-fanlvxqs	109	8	is	be	VBZ
cord-296347-fanlvxqs	109	9	subject	subject	JJ
cord-296347-fanlvxqs	109	10	to	to	IN
cord-296347-fanlvxqs	109	11	trimming	trim	VBG
cord-296347-fanlvxqs	109	12	by	by	IN
cord-296347-fanlvxqs	109	13	cytosolic	cytosolic	JJ
cord-296347-fanlvxqs	109	14	endopeptidases	endopeptidase	NNS
cord-296347-fanlvxqs	109	15	and	and	CC
cord-296347-fanlvxqs	109	16	delivered	deliver	VBN
cord-296347-fanlvxqs	109	17	to	to	IN
cord-296347-fanlvxqs	109	18	the	the	DT
cord-296347-fanlvxqs	109	19	ER	ER	NNP
cord-296347-fanlvxqs	109	20	lumen	lumen	NN
cord-296347-fanlvxqs	109	21	by	by	IN
cord-296347-fanlvxqs	109	22	the	the	DT
cord-296347-fanlvxqs	109	23	TAP	TAP	NNP
cord-296347-fanlvxqs	109	24	transporter	transporter	NN
cord-296347-fanlvxqs	109	25	.	.	.
cord-296347-fanlvxqs	110	1	Further	further	JJ
cord-296347-fanlvxqs	110	2	trimming	trimming	NN
cord-296347-fanlvxqs	110	3	by	by	IN
cord-296347-fanlvxqs	110	4	ER	ER	NNP
cord-296347-fanlvxqs	110	5	-	-	HYPH
cord-296347-fanlvxqs	110	6	resident	resident	JJ
cord-296347-fanlvxqs	110	7	endopeptidases	endopeptidase	NNS
cord-296347-fanlvxqs	110	8	can	can	MD
cord-296347-fanlvxqs	110	9	also	also	RB
cord-296347-fanlvxqs	110	10	occur	occur	VB
cord-296347-fanlvxqs	110	11	to	to	TO
cord-296347-fanlvxqs	110	12	guarantee	guarantee	VB
cord-296347-fanlvxqs	110	13	a	a	DT
cord-296347-fanlvxqs	110	14	custom	custom	NN
cord-296347-fanlvxqs	110	15	-	-	HYPH
cord-296347-fanlvxqs	110	16	fit	fit	NN
cord-296347-fanlvxqs	110	17	of	of	IN
cord-296347-fanlvxqs	110	18	the	the	DT
cord-296347-fanlvxqs	110	19	peptide	peptide	NN
cord-296347-fanlvxqs	110	20	antigens	antigen	NNS
cord-296347-fanlvxqs	110	21	,	,	,
cord-296347-fanlvxqs	110	22	typically	typically	RB
cord-296347-fanlvxqs	110	23	8	8	CD
cord-296347-fanlvxqs	110	24	-	-	SYM
cord-296347-fanlvxqs	110	25	10	10	CD
cord-296347-fanlvxqs	110	26	amino	amino	NN
cord-296347-fanlvxqs	110	27	acids	acid	NNS
cord-296347-fanlvxqs	110	28	long	long	RB
cord-296347-fanlvxqs	110	29	,	,	,
cord-296347-fanlvxqs	110	30	into	into	IN
cord-296347-fanlvxqs	110	31	the	the	DT
cord-296347-fanlvxqs	110	32	peptide	peptide	NN
cord-296347-fanlvxqs	110	33	-	-	HYPH
cord-296347-fanlvxqs	110	34	binding	bind	VBG
cord-296347-fanlvxqs	110	35	groove	groove	NN
cord-296347-fanlvxqs	110	36	on	on	IN
cord-296347-fanlvxqs	110	37	the	the	DT
cord-296347-fanlvxqs	110	38	HC	HC	NNP
cord-296347-fanlvxqs	110	39	/	/	SYM
cord-296347-fanlvxqs	110	40	b	b	NN
cord-296347-fanlvxqs	110	41	2	2	CD
cord-296347-fanlvxqs	110	42	m	m	CD
cord-296347-fanlvxqs	110	43	dimer	dimer	NN
cord-296347-fanlvxqs	110	44	associated	associate	VBN
cord-296347-fanlvxqs	110	45	with	with	IN
cord-296347-fanlvxqs	110	46	the	the	DT
cord-296347-fanlvxqs	110	47	PLC	PLC	NNP
cord-296347-fanlvxqs	110	48	.	.	.
cord-296347-fanlvxqs	111	1	Empty	empty	JJ
cord-296347-fanlvxqs	111	2	HC	HC	NNP
cord-296347-fanlvxqs	111	3	molecules	molecule	NNS
cord-296347-fanlvxqs	111	4	are	be	VBP
cord-296347-fanlvxqs	111	5	detained	detain	VBN
cord-296347-fanlvxqs	111	6	in	in	IN
cord-296347-fanlvxqs	111	7	the	the	DT
cord-296347-fanlvxqs	111	8	ER	ER	NNP
cord-296347-fanlvxqs	111	9	by	by	IN
cord-296347-fanlvxqs	111	10	virtue	virtue	NN
cord-296347-fanlvxqs	111	11	of	of	IN
cord-296347-fanlvxqs	111	12	interaction	interaction	NN
cord-296347-fanlvxqs	111	13	with	with	IN
cord-296347-fanlvxqs	111	14	tapasin	tapasin	NNP
cord-296347-fanlvxqs	111	15	,	,	,
cord-296347-fanlvxqs	111	16	until	until	IN
cord-296347-fanlvxqs	111	17	assembly	assembly	NN
cord-296347-fanlvxqs	111	18	with	with	IN
cord-296347-fanlvxqs	111	19	b	b	NN
cord-296347-fanlvxqs	111	20	2	2	CD
cord-296347-fanlvxqs	111	21	m	m	NN
cord-296347-fanlvxqs	111	22	and	and	CC
cord-296347-fanlvxqs	111	23	peptide	peptide	NN
cord-296347-fanlvxqs	111	24	takes	take	VBZ
cord-296347-fanlvxqs	111	25	place	place	NN
cord-296347-fanlvxqs	111	26	,	,	,
cord-296347-fanlvxqs	111	27	at	at	IN
cord-296347-fanlvxqs	111	28	which	which	WDT
cord-296347-fanlvxqs	111	29	point	point	NN
cord-296347-fanlvxqs	111	30	the	the	DT
cord-296347-fanlvxqs	111	31	HC	HC	NNP
cord-296347-fanlvxqs	111	32	/	/	SYM
cord-296347-fanlvxqs	111	33	b	b	NN
cord-296347-fanlvxqs	111	34	2	2	CD
cord-296347-fanlvxqs	111	35	m	m	NN
cord-296347-fanlvxqs	111	36	/	/	SYM
cord-296347-fanlvxqs	111	37	peptide	peptide	NN
cord-296347-fanlvxqs	111	38	trimeric	trimeric	NNP
cord-296347-fanlvxqs	111	39	complex	complex	NN
cord-296347-fanlvxqs	111	40	is	be	VBZ
cord-296347-fanlvxqs	111	41	released	release	VBN
cord-296347-fanlvxqs	111	42	from	from	IN
cord-296347-fanlvxqs	111	43	the	the	DT
cord-296347-fanlvxqs	111	44	PLC	PLC	NNP
cord-296347-fanlvxqs	111	45	and	and	CC
cord-296347-fanlvxqs	111	46	allowed	allow	VBD
cord-296347-fanlvxqs	111	47	to	to	TO
cord-296347-fanlvxqs	111	48	exit	exit	VB
cord-296347-fanlvxqs	111	49	the	the	DT
cord-296347-fanlvxqs	111	50	ER	er	NN
cord-296347-fanlvxqs	111	51	and	and	CC
cord-296347-fanlvxqs	111	52	enter	enter	VB
cord-296347-fanlvxqs	111	53	the	the	DT
cord-296347-fanlvxqs	111	54	secretory	secretory	JJ
cord-296347-fanlvxqs	111	55	pathway	pathway	NN
cord-296347-fanlvxqs	111	56	.	.	.
cord-296347-fanlvxqs	112	1	Once	once	RB
cord-296347-fanlvxqs	112	2	displayed	display	VBN
cord-296347-fanlvxqs	112	3	at	at	IN
cord-296347-fanlvxqs	112	4	the	the	DT
cord-296347-fanlvxqs	112	5	cell	cell	NN
cord-296347-fanlvxqs	112	6	surface	surface	NN
cord-296347-fanlvxqs	112	7	,	,	,
cord-296347-fanlvxqs	112	8	the	the	DT
cord-296347-fanlvxqs	112	9	antigen	antigen	NN
cord-296347-fanlvxqs	112	10	-	-	HYPH
cord-296347-fanlvxqs	112	11	loaded	load	VBN
cord-296347-fanlvxqs	112	12	class	class	NN
cord-296347-fanlvxqs	112	13	I	-PRON-	PRP
cord-296347-fanlvxqs	112	14	MHC	MHC	NNP
cord-296347-fanlvxqs	112	15	complex	complex	NN
cord-296347-fanlvxqs	112	16	is	be	VBZ
cord-296347-fanlvxqs	112	17	ready	ready	JJ
cord-296347-fanlvxqs	112	18	for	for	IN
cord-296347-fanlvxqs	112	19	inspection	inspection	NN
cord-296347-fanlvxqs	112	20	by	by	IN
cord-296347-fanlvxqs	112	21	the	the	DT
cord-296347-fanlvxqs	112	22	T	T	NNP
cord-296347-fanlvxqs	112	23	cell	cell	NN
cord-296347-fanlvxqs	112	24	receptor	receptor	NN
cord-296347-fanlvxqs	112	25	(	(	-LRB-
cord-296347-fanlvxqs	112	26	TCR	TCR	NNP
cord-296347-fanlvxqs	112	27	)	)	-RRB-
cord-296347-fanlvxqs	112	28	on	on	IN
cord-296347-fanlvxqs	112	29	circulating	circulate	VBG
cord-296347-fanlvxqs	112	30	cytotoxic	cytotoxic	JJ
cord-296347-fanlvxqs	112	31	CD8	CD8	NNP
cord-296347-fanlvxqs	112	32	þ	þ	NNP
cord-296347-fanlvxqs	112	33	T	t	NN
cord-296347-fanlvxqs	112	34	cells	cell	NNS
cord-296347-fanlvxqs	112	35	(	(	-LRB-
cord-296347-fanlvxqs	112	36	Cresswell	Cresswell	NNP
cord-296347-fanlvxqs	112	37	et	et	NNP
cord-296347-fanlvxqs	112	38	al	al	NNP
cord-296347-fanlvxqs	112	39	.	.	NNP
cord-296347-fanlvxqs	112	40	,	,	,
cord-296347-fanlvxqs	112	41	2005	2005	CD
cord-296347-fanlvxqs	112	42	;	;	:
cord-296347-fanlvxqs	112	43	Heemels	Heemels	NNP
cord-296347-fanlvxqs	112	44	and	and	CC
cord-296347-fanlvxqs	112	45	Ploegh	Ploegh	NNP
cord-296347-fanlvxqs	112	46	,	,	,
cord-296347-fanlvxqs	112	47	1995	1995	CD
cord-296347-fanlvxqs	112	48	;	;	:
cord-296347-fanlvxqs	112	49	Rammensee	Rammensee	NNP
cord-296347-fanlvxqs	112	50	,	,	,
cord-296347-fanlvxqs	112	51	2002	2002	CD
cord-296347-fanlvxqs	112	52	Rammensee	Rammensee	NNP
cord-296347-fanlvxqs	112	53	,	,	,
cord-296347-fanlvxqs	112	54	,	,	,
cord-296347-fanlvxqs	112	55	2004	2004	CD
cord-296347-fanlvxqs	112	56	.	.	.
cord-296347-fanlvxqs	113	1	Figure	figure	NN
cord-296347-fanlvxqs	113	2	1	1	CD
cord-296347-fanlvxqs	113	3	Common	common	JJ
cord-296347-fanlvxqs	113	4	principles	principle	NNS
cord-296347-fanlvxqs	113	5	in	in	IN
cord-296347-fanlvxqs	113	6	antigen	antigen	NN
cord-296347-fanlvxqs	113	7	processing	processing	NN
cord-296347-fanlvxqs	113	8	and	and	CC
cord-296347-fanlvxqs	113	9	presentation	presentation	NN
cord-296347-fanlvxqs	113	10	by	by	IN
cord-296347-fanlvxqs	113	11	class	class	NN
cord-296347-fanlvxqs	113	12	I	i	NN
cord-296347-fanlvxqs	113	13	and	and	CC
cord-296347-fanlvxqs	113	14	class	class	NN
cord-296347-fanlvxqs	113	15	II	II	NNP
cord-296347-fanlvxqs	113	16	MHC	MHC	NNP
cord-296347-fanlvxqs	113	17	molecules	molecule	NNS
cord-296347-fanlvxqs	113	18	.	.	.
cord-296347-fanlvxqs	114	1	In	in	IN
cord-296347-fanlvxqs	114	2	the	the	DT
cord-296347-fanlvxqs	114	3	class	class	NN
cord-296347-fanlvxqs	114	4	I	-PRON-	PRP
cord-296347-fanlvxqs	114	5	pathway	pathway	VBP
cord-296347-fanlvxqs	114	6	,	,	,
cord-296347-fanlvxqs	114	7	endogenous	endogenous	JJ
cord-296347-fanlvxqs	114	8	antigens	antigen	NNS
cord-296347-fanlvxqs	114	9	are	be	VBP
cord-296347-fanlvxqs	114	10	derived	derive	VBN
cord-296347-fanlvxqs	114	11	from	from	IN
cord-296347-fanlvxqs	114	12	cytosolic	cytosolic	JJ
cord-296347-fanlvxqs	114	13	proteolysis	proteolysis	NN
cord-296347-fanlvxqs	114	14	and	and	CC
cord-296347-fanlvxqs	114	15	delivered	deliver	VBD
cord-296347-fanlvxqs	114	16	to	to	IN
cord-296347-fanlvxqs	114	17	the	the	DT
cord-296347-fanlvxqs	114	18	ER	ER	NNP
cord-296347-fanlvxqs	114	19	lumen	lumen	NN
cord-296347-fanlvxqs	114	20	,	,	,
cord-296347-fanlvxqs	114	21	where	where	WRB
cord-296347-fanlvxqs	114	22	loading	load	VBG
cord-296347-fanlvxqs	114	23	onto	onto	IN
cord-296347-fanlvxqs	114	24	class	class	NN
cord-296347-fanlvxqs	114	25	I	-PRON-	PRP
cord-296347-fanlvxqs	114	26	MHC	MHC	NNP
cord-296347-fanlvxqs	114	27	products	product	NNS
cord-296347-fanlvxqs	114	28	takes	take	VBZ
cord-296347-fanlvxqs	114	29	place	place	NN
cord-296347-fanlvxqs	114	30	.	.	.
cord-296347-fanlvxqs	115	1	The	the	DT
cord-296347-fanlvxqs	115	2	assembled	assembled	JJ
cord-296347-fanlvxqs	115	3	complex	complex	NN
cord-296347-fanlvxqs	115	4	is	be	VBZ
cord-296347-fanlvxqs	115	5	then	then	RB
cord-296347-fanlvxqs	115	6	sorted	sort	VBN
cord-296347-fanlvxqs	115	7	to	to	IN
cord-296347-fanlvxqs	115	8	the	the	DT
cord-296347-fanlvxqs	115	9	cell	cell	NN
cord-296347-fanlvxqs	115	10	surface	surface	NN
cord-296347-fanlvxqs	115	11	.	.	.
cord-296347-fanlvxqs	116	1	In	in	IN
cord-296347-fanlvxqs	116	2	the	the	DT
cord-296347-fanlvxqs	116	3	class	class	NN
cord-296347-fanlvxqs	116	4	II	II	NNP
cord-296347-fanlvxqs	116	5	pathway	pathway	NN
cord-296347-fanlvxqs	116	6	,	,	,
cord-296347-fanlvxqs	116	7	exogenous	exogenous	JJ
cord-296347-fanlvxqs	116	8	material	material	NN
cord-296347-fanlvxqs	116	9	is	be	VBZ
cord-296347-fanlvxqs	116	10	internalized	internalize	VBN
cord-296347-fanlvxqs	116	11	from	from	IN
cord-296347-fanlvxqs	116	12	the	the	DT
cord-296347-fanlvxqs	116	13	extracellular	extracellular	JJ
cord-296347-fanlvxqs	116	14	space	space	NN
cord-296347-fanlvxqs	116	15	and	and	CC
cord-296347-fanlvxqs	116	16	delivered	deliver	VBD
cord-296347-fanlvxqs	116	17	to	to	IN
cord-296347-fanlvxqs	116	18	the	the	DT
cord-296347-fanlvxqs	116	19	lysosome	lysosome	NN
cord-296347-fanlvxqs	116	20	,	,	,
cord-296347-fanlvxqs	116	21	where	where	WRB
cord-296347-fanlvxqs	116	22	processing	processing	NN
cord-296347-fanlvxqs	116	23	and	and	CC
cord-296347-fanlvxqs	116	24	loading	load	VBG
cord-296347-fanlvxqs	116	25	onto	onto	IN
cord-296347-fanlvxqs	116	26	MHC	MHC	NNP
cord-296347-fanlvxqs	116	27	products	product	NNS
cord-296347-fanlvxqs	116	28	occur	occur	VBP
cord-296347-fanlvxqs	116	29	.	.	.
cord-296347-fanlvxqs	117	1	Sorting	sort	VBG
cord-296347-fanlvxqs	117	2	through	through	IN
cord-296347-fanlvxqs	117	3	the	the	DT
cord-296347-fanlvxqs	117	4	secretory	secretory	JJ
cord-296347-fanlvxqs	117	5	pathway	pathway	NN
cord-296347-fanlvxqs	117	6	then	then	RB
cord-296347-fanlvxqs	117	7	delivers	deliver	VBZ
cord-296347-fanlvxqs	117	8	the	the	DT
cord-296347-fanlvxqs	117	9	class	class	NN
cord-296347-fanlvxqs	117	10	II	II	NNP
cord-296347-fanlvxqs	117	11	complex	complex	JJ
cord-296347-fanlvxqs	117	12	to	to	IN
cord-296347-fanlvxqs	117	13	the	the	DT
cord-296347-fanlvxqs	117	14	cell	cell	NN
cord-296347-fanlvxqs	117	15	surface	surface	NN
cord-296347-fanlvxqs	117	16	.	.	.
cord-296347-fanlvxqs	118	1	Class	class	NN
cord-296347-fanlvxqs	118	2	I	-PRON-	PRP
cord-296347-fanlvxqs	118	3	MHC	MHC	NNP
cord-296347-fanlvxqs	118	4	products	product	NNS
cord-296347-fanlvxqs	118	5	on	on	IN
cord-296347-fanlvxqs	118	6	most	most	JJS
cord-296347-fanlvxqs	118	7	cells	cell	NNS
cord-296347-fanlvxqs	118	8	present	present	VBP
cord-296347-fanlvxqs	118	9	exclusively	exclusively	RB
cord-296347-fanlvxqs	118	10	'	'	''
cord-296347-fanlvxqs	118	11	'	'	``
cord-296347-fanlvxqs	118	12	self	self	NN
cord-296347-fanlvxqs	118	13	'	'	''
cord-296347-fanlvxqs	118	14	'	'	''
cord-296347-fanlvxqs	118	15	peptides	peptide	NNS
cord-296347-fanlvxqs	118	16	,	,	,
cord-296347-fanlvxqs	118	17	derived	derive	VBN
cord-296347-fanlvxqs	118	18	from	from	IN
cord-296347-fanlvxqs	118	19	the	the	DT
cord-296347-fanlvxqs	118	20	cell	cell	NN
cord-296347-fanlvxqs	118	21	's	's	POS
cord-296347-fanlvxqs	118	22	own	own	JJ
cord-296347-fanlvxqs	118	23	proteins	protein	NNS
cord-296347-fanlvxqs	118	24	,	,	,
cord-296347-fanlvxqs	118	25	the	the	DT
cord-296347-fanlvxqs	118	26	majority	majority	NN
cord-296347-fanlvxqs	118	27	of	of	IN
cord-296347-fanlvxqs	118	28	which	which	WDT
cord-296347-fanlvxqs	118	29	results	result	VBZ
cord-296347-fanlvxqs	118	30	from	from	IN
cord-296347-fanlvxqs	118	31	protein	protein	NN
cord-296347-fanlvxqs	118	32	synthesis	synthesis	NN
cord-296347-fanlvxqs	118	33	on	on	IN
cord-296347-fanlvxqs	118	34	free	free	JJ
cord-296347-fanlvxqs	118	35	ribosomes	ribosome	NNS
cord-296347-fanlvxqs	118	36	in	in	IN
cord-296347-fanlvxqs	118	37	the	the	DT
cord-296347-fanlvxqs	118	38	cytoplasm	cytoplasm	NN
cord-296347-fanlvxqs	118	39	.	.	.
cord-296347-fanlvxqs	119	1	Because	because	IN
cord-296347-fanlvxqs	119	2	of	of	IN
cord-296347-fanlvxqs	119	3	the	the	DT
cord-296347-fanlvxqs	119	4	intrinsic	intrinsic	JJ
cord-296347-fanlvxqs	119	5	error	error	NN
cord-296347-fanlvxqs	119	6	-	-	HYPH
cord-296347-fanlvxqs	119	7	prone	prone	JJ
cord-296347-fanlvxqs	119	8	nature	nature	NN
cord-296347-fanlvxqs	119	9	of	of	IN
cord-296347-fanlvxqs	119	10	protein	protein	NN
cord-296347-fanlvxqs	119	11	synthesis	synthesis	NN
cord-296347-fanlvxqs	119	12	and	and	CC
cord-296347-fanlvxqs	119	13	folding	folding	NN
cord-296347-fanlvxqs	119	14	,	,	,
cord-296347-fanlvxqs	119	15	a	a	DT
cord-296347-fanlvxqs	119	16	sizable	sizable	JJ
cord-296347-fanlvxqs	119	17	fraction	fraction	NN
cord-296347-fanlvxqs	119	18	of	of	IN
cord-296347-fanlvxqs	119	19	translation	translation	NN
cord-296347-fanlvxqs	119	20	products	product	NNS
cord-296347-fanlvxqs	119	21	(	(	-LRB-
cord-296347-fanlvxqs	119	22	estimated	estimate	VBN
cord-296347-fanlvxqs	119	23	at	at	IN
cord-296347-fanlvxqs	119	24	up	up	IN
cord-296347-fanlvxqs	119	25	to	to	TO
cord-296347-fanlvxqs	119	26	30	30	CD
cord-296347-fanlvxqs	119	27	%	%	NN
cord-296347-fanlvxqs	119	28	)	)	-RRB-
cord-296347-fanlvxqs	119	29	may	may	MD
cord-296347-fanlvxqs	119	30	never	never	RB
cord-296347-fanlvxqs	119	31	result	result	VB
cord-296347-fanlvxqs	119	32	in	in	IN
cord-296347-fanlvxqs	119	33	a	a	DT
cord-296347-fanlvxqs	119	34	finished	finished	JJ
cord-296347-fanlvxqs	119	35	product	product	NN
cord-296347-fanlvxqs	119	36	.	.	.
cord-296347-fanlvxqs	120	1	These	these	DT
cord-296347-fanlvxqs	120	2	defective	defective	JJ
cord-296347-fanlvxqs	120	3	ribosomal	ribosomal	JJ
cord-296347-fanlvxqs	120	4	products	product	NNS
cord-296347-fanlvxqs	120	5	(	(	-LRB-
cord-296347-fanlvxqs	120	6	DRIPs	drip	NNS
cord-296347-fanlvxqs	120	7	)	)	-RRB-
cord-296347-fanlvxqs	120	8	are	be	VBP
cord-296347-fanlvxqs	120	9	destroyed	destroy	VBN
cord-296347-fanlvxqs	120	10	within	within	IN
cord-296347-fanlvxqs	120	11	30	30	CD
cord-296347-fanlvxqs	120	12	min	min	NN
cord-296347-fanlvxqs	120	13	of	of	IN
cord-296347-fanlvxqs	120	14	their	-PRON-	PRP$
cord-296347-fanlvxqs	120	15	synthesis	synthesis	NN
cord-296347-fanlvxqs	120	16	by	by	IN
cord-296347-fanlvxqs	120	17	the	the	DT
cord-296347-fanlvxqs	120	18	cytosolic	cytosolic	JJ
cord-296347-fanlvxqs	120	19	proteasomal	proteasomal	JJ
cord-296347-fanlvxqs	120	20	pathway	pathway	NN
cord-296347-fanlvxqs	120	21	and	and	CC
cord-296347-fanlvxqs	120	22	enter	enter	VB
cord-296347-fanlvxqs	120	23	the	the	DT
cord-296347-fanlvxqs	120	24	class	class	NN
cord-296347-fanlvxqs	120	25	I	-PRON-	PRP
cord-296347-fanlvxqs	120	26	MHC	MHC	NNP
cord-296347-fanlvxqs	121	1	antigen	antigen	NN
cord-296347-fanlvxqs	121	2	presentation	presentation	NN
cord-296347-fanlvxqs	121	3	pathway	pathway	NN
cord-296347-fanlvxqs	121	4	(	(	-LRB-
cord-296347-fanlvxqs	121	5	Yewdell	Yewdell	NNP
cord-296347-fanlvxqs	121	6	et	et	NNP
cord-296347-fanlvxqs	121	7	al	al	NNP
cord-296347-fanlvxqs	121	8	.	.	NNP
cord-296347-fanlvxqs	121	9	,	,	,
cord-296347-fanlvxqs	121	10	2001	2001	CD
cord-296347-fanlvxqs	121	11	)	)	-RRB-
cord-296347-fanlvxqs	121	12	.	.	.
cord-296347-fanlvxqs	122	1	In	in	IN
cord-296347-fanlvxqs	122	2	tumor	tumor	NN
cord-296347-fanlvxqs	122	3	cells	cell	NNS
cord-296347-fanlvxqs	122	4	or	or	CC
cord-296347-fanlvxqs	122	5	cells	cell	NNS
cord-296347-fanlvxqs	122	6	infected	infect	VBN
cord-296347-fanlvxqs	122	7	by	by	IN
cord-296347-fanlvxqs	122	8	a	a	DT
cord-296347-fanlvxqs	122	9	virus	virus	NN
cord-296347-fanlvxqs	122	10	,	,	,
cord-296347-fanlvxqs	122	11	mutated	mutate	VBN
cord-296347-fanlvxqs	122	12	forms	form	NNS
cord-296347-fanlvxqs	122	13	of	of	IN
cord-296347-fanlvxqs	122	14	endogenous	endogenous	JJ
cord-296347-fanlvxqs	122	15	proteins	protein	NNS
cord-296347-fanlvxqs	122	16	or	or	CC
cord-296347-fanlvxqs	122	17	viral	viral	JJ
cord-296347-fanlvxqs	122	18	proteins	protein	NNS
cord-296347-fanlvxqs	122	19	will	will	MD
cord-296347-fanlvxqs	122	20	compete	compete	VB
cord-296347-fanlvxqs	122	21	with	with	IN
cord-296347-fanlvxqs	122	22	the	the	DT
cord-296347-fanlvxqs	122	23	host	host	NN
cord-296347-fanlvxqs	122	24	's	's	POS
cord-296347-fanlvxqs	122	25	own	own	JJ
cord-296347-fanlvxqs	122	26	proteins	protein	NNS
cord-296347-fanlvxqs	122	27	for	for	IN
cord-296347-fanlvxqs	122	28	presentation	presentation	NN
cord-296347-fanlvxqs	122	29	by	by	IN
cord-296347-fanlvxqs	122	30	class	class	NN
cord-296347-fanlvxqs	122	31	I	-PRON-	PRP
cord-296347-fanlvxqs	122	32	MHC	MHC	NNP
cord-296347-fanlvxqs	122	33	products	product	NNS
cord-296347-fanlvxqs	122	34	.	.	.
cord-296347-fanlvxqs	123	1	As	as	IN
cord-296347-fanlvxqs	123	2	'	'	``
cord-296347-fanlvxqs	123	3	'	'	``
cord-296347-fanlvxqs	123	4	non	non	JJ
cord-296347-fanlvxqs	123	5	-	-	JJ
cord-296347-fanlvxqs	123	6	self	self	JJ
cord-296347-fanlvxqs	123	7	'	'	''
cord-296347-fanlvxqs	123	8	'	'	''
cord-296347-fanlvxqs	124	1	(	(	-LRB-
cord-296347-fanlvxqs	124	2	tumor	tumor	NN
cord-296347-fanlvxqs	124	3	-	-	HYPH
cord-296347-fanlvxqs	124	4	or	or	CC
cord-296347-fanlvxqs	124	5	virus	virus	NN
cord-296347-fanlvxqs	124	6	-	-	HYPH
cord-296347-fanlvxqs	124	7	derived	derive	VBN
cord-296347-fanlvxqs	124	8	)	)	-RRB-
cord-296347-fanlvxqs	124	9	peptides	peptide	NNS
cord-296347-fanlvxqs	124	10	displayed	display	VBN
cord-296347-fanlvxqs	124	11	in	in	IN
cord-296347-fanlvxqs	124	12	the	the	DT
cord-296347-fanlvxqs	124	13	context	context	NN
cord-296347-fanlvxqs	124	14	of	of	IN
cord-296347-fanlvxqs	124	15	class	class	NN
cord-296347-fanlvxqs	124	16	I	-PRON-	PRP
cord-296347-fanlvxqs	124	17	MHC	MHC	NNP
cord-296347-fanlvxqs	124	18	products	product	NNS
cord-296347-fanlvxqs	124	19	accumulate	accumulate	VBP
cord-296347-fanlvxqs	124	20	at	at	IN
cord-296347-fanlvxqs	124	21	the	the	DT
cord-296347-fanlvxqs	124	22	cell	cell	NN
cord-296347-fanlvxqs	124	23	surface	surface	NN
cord-296347-fanlvxqs	124	24	,	,	,
cord-296347-fanlvxqs	124	25	their	-PRON-	PRP$
cord-296347-fanlvxqs	124	26	chance	chance	NN
cord-296347-fanlvxqs	124	27	of	of	IN
cord-296347-fanlvxqs	124	28	triggering	trigger	VBG
cord-296347-fanlvxqs	124	29	activation	activation	NN
cord-296347-fanlvxqs	124	30	of	of	IN
cord-296347-fanlvxqs	124	31	CD8	CD8	NNP
cord-296347-fanlvxqs	124	32	þ	þ	NNP
cord-296347-fanlvxqs	124	33	T	T	NNP
cord-296347-fanlvxqs	124	34	cells	cell	NNS
cord-296347-fanlvxqs	124	35	with	with	IN
cord-296347-fanlvxqs	124	36	a	a	DT
cord-296347-fanlvxqs	124	37	cognate	cognate	JJ
cord-296347-fanlvxqs	124	38	receptor	receptor	NN
cord-296347-fanlvxqs	124	39	increases	increase	NNS
cord-296347-fanlvxqs	124	40	.	.	.
cord-296347-fanlvxqs	125	1	The	the	DT
cord-296347-fanlvxqs	125	2	activated	activate	VBN
cord-296347-fanlvxqs	125	3	cytotoxic	cytotoxic	JJ
cord-296347-fanlvxqs	125	4	CD8	CD8	NNP
cord-296347-fanlvxqs	125	5	þ	þ	NNP
cord-296347-fanlvxqs	125	6	T	T	NNP
cord-296347-fanlvxqs	125	7	lymphocytes	lymphocyte	NNS
cord-296347-fanlvxqs	125	8	will	will	MD
cord-296347-fanlvxqs	125	9	then	then	RB
cord-296347-fanlvxqs	125	10	lyse	lyse	VB
cord-296347-fanlvxqs	125	11	the	the	DT
cord-296347-fanlvxqs	125	12	target	target	NN
cord-296347-fanlvxqs	125	13	cell	cell	NN
cord-296347-fanlvxqs	125	14	by	by	IN
cord-296347-fanlvxqs	125	15	releasing	release	VBG
cord-296347-fanlvxqs	125	16	perforin	perforin	NNP
cord-296347-fanlvxqs	125	17	and	and	CC
cord-296347-fanlvxqs	125	18	granzymes	granzyme	NNS
cord-296347-fanlvxqs	125	19	or	or	CC
cord-296347-fanlvxqs	125	20	by	by	IN
cord-296347-fanlvxqs	125	21	Fas	Fas	NNP
cord-296347-fanlvxqs	125	22	ligand	ligand	NN
cord-296347-fanlvxqs	125	23	engagement	engagement	NN
cord-296347-fanlvxqs	125	24	.	.	.
cord-296347-fanlvxqs	126	1	Secretion	secretion	NN
cord-296347-fanlvxqs	126	2	of	of	IN
cord-296347-fanlvxqs	126	3	IFN	IFN	NNP
cord-296347-fanlvxqs	126	4	-	-	HYPH
cord-296347-fanlvxqs	126	5	g	g	NNP
cord-296347-fanlvxqs	126	6	and	and	CC
cord-296347-fanlvxqs	126	7	tumor	tumor	NN
cord-296347-fanlvxqs	126	8	necrosis	necrosis	NN
cord-296347-fanlvxqs	126	9	factor	factor	NN
cord-296347-fanlvxqs	126	10	-	-	:
cord-296347-fanlvxqs	126	11	a	a	DT
cord-296347-fanlvxqs	126	12	(	(	-LRB-
cord-296347-fanlvxqs	126	13	TNF	TNF	NNP
cord-296347-fanlvxqs	126	14	-	-	HYPH
cord-296347-fanlvxqs	126	15	a	a	LS
cord-296347-fanlvxqs	126	16	)	)	-RRB-
cord-296347-fanlvxqs	126	17	also	also	RB
cord-296347-fanlvxqs	126	18	aids	aid	VBZ
cord-296347-fanlvxqs	126	19	in	in	IN
cord-296347-fanlvxqs	126	20	elimination	elimination	NN
cord-296347-fanlvxqs	126	21	of	of	IN
cord-296347-fanlvxqs	126	22	infected	infected	JJ
cord-296347-fanlvxqs	126	23	and	and	CC
cord-296347-fanlvxqs	126	24	tumor	tumor	NN
cord-296347-fanlvxqs	126	25	cells	cell	NNS
cord-296347-fanlvxqs	126	26	by	by	IN
cord-296347-fanlvxqs	126	27	cytotoxic	cytotoxic	JJ
cord-296347-fanlvxqs	126	28	T	t	NN
cord-296347-fanlvxqs	126	29	lymphocytes	lymphocyte	NNS
cord-296347-fanlvxqs	126	30	(	(	-LRB-
cord-296347-fanlvxqs	126	31	CTLs	CTLs	NNP
cord-296347-fanlvxqs	126	32	)	)	-RRB-
cord-296347-fanlvxqs	126	33	(	(	-LRB-
cord-296347-fanlvxqs	126	34	Andersen	Andersen	NNP
cord-296347-fanlvxqs	126	35	et	et	NNP
cord-296347-fanlvxqs	126	36	al	al	NNP
cord-296347-fanlvxqs	126	37	.	.	NNP
cord-296347-fanlvxqs	126	38	,	,	,
cord-296347-fanlvxqs	126	39	2006	2006	CD
cord-296347-fanlvxqs	126	40	;	;	:
cord-296347-fanlvxqs	126	41	Castelli	Castelli	NNP
cord-296347-fanlvxqs	126	42	et	et	NNP
cord-296347-fanlvxqs	126	43	al	al	NNP
cord-296347-fanlvxqs	126	44	.	.	NNP
cord-296347-fanlvxqs	126	45	,	,	,
cord-296347-fanlvxqs	126	46	2000	2000	CD
cord-296347-fanlvxqs	126	47	)	)	-RRB-
cord-296347-fanlvxqs	126	48	.	.	.
cord-296347-fanlvxqs	127	1	The	the	DT
cord-296347-fanlvxqs	127	2	selective	selective	JJ
cord-296347-fanlvxqs	127	3	pressure	pressure	NN
cord-296347-fanlvxqs	127	4	imposed	impose	VBN
cord-296347-fanlvxqs	127	5	by	by	IN
cord-296347-fanlvxqs	127	6	immune	immune	JJ
cord-296347-fanlvxqs	127	7	surveillance	surveillance	NN
cord-296347-fanlvxqs	127	8	has	have	VBZ
cord-296347-fanlvxqs	127	9	made	make	VBN
cord-296347-fanlvxqs	127	10	loss	loss	NN
cord-296347-fanlvxqs	127	11	of	of	IN
cord-296347-fanlvxqs	127	12	class	class	NN
cord-296347-fanlvxqs	127	13	I	-PRON-	PRP
cord-296347-fanlvxqs	127	14	MHC	MHC	NNP
cord-296347-fanlvxqs	127	15	expression	expression	NN
cord-296347-fanlvxqs	127	16	a	a	DT
cord-296347-fanlvxqs	127	17	hallmark	hallmark	NN
cord-296347-fanlvxqs	127	18	of	of	IN
cord-296347-fanlvxqs	127	19	some	some	DT
cord-296347-fanlvxqs	127	20	tumors	tumor	NNS
cord-296347-fanlvxqs	127	21	and	and	CC
cord-296347-fanlvxqs	127	22	virus	virus	NN
cord-296347-fanlvxqs	127	23	-	-	HYPH
cord-296347-fanlvxqs	127	24	infected	infect	VBN
cord-296347-fanlvxqs	127	25	cells	cell	NNS
cord-296347-fanlvxqs	127	26	,	,	,
cord-296347-fanlvxqs	127	27	as	as	IN
cord-296347-fanlvxqs	127	28	this	this	DT
cord-296347-fanlvxqs	127	29	allows	allow	VBZ
cord-296347-fanlvxqs	127	30	them	-PRON-	PRP
cord-296347-fanlvxqs	127	31	to	to	TO
cord-296347-fanlvxqs	127	32	be	be	VB
cord-296347-fanlvxqs	127	33	invisible	invisible	JJ
cord-296347-fanlvxqs	127	34	to	to	IN
cord-296347-fanlvxqs	127	35	CTLs	ctl	NNS
cord-296347-fanlvxqs	127	36	.	.	.
cord-296347-fanlvxqs	128	1	There	there	EX
cord-296347-fanlvxqs	128	2	is	be	VBZ
cord-296347-fanlvxqs	128	3	,	,	,
cord-296347-fanlvxqs	128	4	however	however	RB
cord-296347-fanlvxqs	128	5	,	,	,
cord-296347-fanlvxqs	128	6	a	a	DT
cord-296347-fanlvxqs	128	7	backup	backup	JJ
cord-296347-fanlvxqs	128	8	system	system	NN
cord-296347-fanlvxqs	128	9	for	for	IN
cord-296347-fanlvxqs	128	10	when	when	WRB
cord-296347-fanlvxqs	128	11	lack	lack	NN
cord-296347-fanlvxqs	128	12	of	of	IN
cord-296347-fanlvxqs	128	13	class	class	NN
cord-296347-fanlvxqs	128	14	I	-PRON-	PRP
cord-296347-fanlvxqs	128	15	MHC	MHC	NNP
cord-296347-fanlvxqs	128	16	expression	expression	NN
cord-296347-fanlvxqs	128	17	impairs	impair	VBZ
cord-296347-fanlvxqs	128	18	the	the	DT
cord-296347-fanlvxqs	128	19	CD8	CD8	NNP
cord-296347-fanlvxqs	128	20	þ	þ	NNP
cord-296347-fanlvxqs	128	21	T	T	NNP
cord-296347-fanlvxqs	128	22	cell	cell	NN
cord-296347-fanlvxqs	128	23	cytotoxic	cytotoxic	JJ
cord-296347-fanlvxqs	128	24	response	response	NN
cord-296347-fanlvxqs	128	25	:	:	:
cord-296347-fanlvxqs	128	26	NK	NK	NNP
cord-296347-fanlvxqs	128	27	cells	cell	NNS
cord-296347-fanlvxqs	128	28	.	.	.
cord-296347-fanlvxqs	129	1	NK	NK	NNP
cord-296347-fanlvxqs	129	2	cells	cell	NNS
cord-296347-fanlvxqs	129	3	display	display	VBP
cord-296347-fanlvxqs	129	4	both	both	CC
cord-296347-fanlvxqs	129	5	activating	activate	VBG
cord-296347-fanlvxqs	129	6	and	and	CC
cord-296347-fanlvxqs	129	7	inhibitory	inhibitory	JJ
cord-296347-fanlvxqs	129	8	receptors	receptor	NNS
cord-296347-fanlvxqs	129	9	at	at	IN
cord-296347-fanlvxqs	129	10	their	-PRON-	PRP$
cord-296347-fanlvxqs	129	11	surface	surface	NN
cord-296347-fanlvxqs	129	12	,	,	,
cord-296347-fanlvxqs	129	13	which	which	WDT
cord-296347-fanlvxqs	129	14	recognize	recognize	VBP
cord-296347-fanlvxqs	129	15	different	different	JJ
cord-296347-fanlvxqs	129	16	ligands	ligand	NNS
cord-296347-fanlvxqs	129	17	at	at	IN
cord-296347-fanlvxqs	129	18	the	the	DT
cord-296347-fanlvxqs	129	19	surface	surface	NN
cord-296347-fanlvxqs	129	20	of	of	IN
cord-296347-fanlvxqs	129	21	target	target	NN
cord-296347-fanlvxqs	129	22	cells	cell	NNS
cord-296347-fanlvxqs	129	23	.	.	.
cord-296347-fanlvxqs	130	1	NK	NK	NNP
cord-296347-fanlvxqs	130	2	cell	cell	NN
cord-296347-fanlvxqs	130	3	activity	activity	NN
cord-296347-fanlvxqs	130	4	is	be	VBZ
cord-296347-fanlvxqs	130	5	ultimately	ultimately	RB
cord-296347-fanlvxqs	130	6	determined	determine	VBN
cord-296347-fanlvxqs	130	7	by	by	IN
cord-296347-fanlvxqs	130	8	the	the	DT
cord-296347-fanlvxqs	130	9	integration	integration	NN
cord-296347-fanlvxqs	130	10	of	of	IN
cord-296347-fanlvxqs	130	11	signals	signal	NNS
cord-296347-fanlvxqs	130	12	that	that	WDT
cord-296347-fanlvxqs	130	13	are	be	VBP
cord-296347-fanlvxqs	130	14	perceived	perceive	VBN
cord-296347-fanlvxqs	130	15	by	by	IN
cord-296347-fanlvxqs	130	16	the	the	DT
cord-296347-fanlvxqs	130	17	NK	NK	NNP
cord-296347-fanlvxqs	130	18	cell	cell	NN
cord-296347-fanlvxqs	130	19	surface	surface	NN
cord-296347-fanlvxqs	130	20	receptors	receptor	NNS
cord-296347-fanlvxqs	130	21	(	(	-LRB-
cord-296347-fanlvxqs	130	22	Lanier	Lanier	NNP
cord-296347-fanlvxqs	130	23	,	,	,
cord-296347-fanlvxqs	130	24	2005	2005	CD
cord-296347-fanlvxqs	130	25	)	)	-RRB-
cord-296347-fanlvxqs	130	26	.	.	.
cord-296347-fanlvxqs	131	1	All	all	DT
cord-296347-fanlvxqs	131	2	NK	NK	NNP
cord-296347-fanlvxqs	131	3	cells	cell	NNS
cord-296347-fanlvxqs	131	4	express	express	VBP
cord-296347-fanlvxqs	131	5	at	at	IN
cord-296347-fanlvxqs	131	6	least	least	RBS
cord-296347-fanlvxqs	131	7	one	one	CD
cord-296347-fanlvxqs	131	8	inhibitory	inhibitory	JJ
cord-296347-fanlvxqs	131	9	receptor	receptor	NN
cord-296347-fanlvxqs	131	10	,	,	,
cord-296347-fanlvxqs	131	11	which	which	WDT
cord-296347-fanlvxqs	131	12	engages	engage	VBZ
cord-296347-fanlvxqs	131	13	class	class	NN
cord-296347-fanlvxqs	131	14	I	-PRON-	PRP
cord-296347-fanlvxqs	131	15	MHC	MHC	NNP
cord-296347-fanlvxqs	131	16	molecules	molecule	NNS
cord-296347-fanlvxqs	131	17	on	on	IN
cord-296347-fanlvxqs	131	18	the	the	DT
cord-296347-fanlvxqs	131	19	surface	surface	NN
cord-296347-fanlvxqs	131	20	of	of	IN
cord-296347-fanlvxqs	131	21	the	the	DT
cord-296347-fanlvxqs	131	22	target	target	NN
cord-296347-fanlvxqs	131	23	cell	cell	NN
cord-296347-fanlvxqs	131	24	,	,	,
cord-296347-fanlvxqs	131	25	resulting	result	VBG
cord-296347-fanlvxqs	131	26	in	in	IN
cord-296347-fanlvxqs	131	27	downregulation	downregulation	NN
cord-296347-fanlvxqs	131	28	of	of	IN
cord-296347-fanlvxqs	131	29	NK	NK	NNP
cord-296347-fanlvxqs	131	30	cell	cell	NN
cord-296347-fanlvxqs	131	31	effector	effector	NN
cord-296347-fanlvxqs	131	32	functions	function	NNS
cord-296347-fanlvxqs	131	33	.	.	.
cord-296347-fanlvxqs	132	1	Low	low	JJ
cord-296347-fanlvxqs	132	2	levels	level	NNS
cord-296347-fanlvxqs	132	3	or	or	CC
cord-296347-fanlvxqs	132	4	absence	absence	NN
cord-296347-fanlvxqs	132	5	of	of	IN
cord-296347-fanlvxqs	132	6	class	class	NN
cord-296347-fanlvxqs	132	7	I	-PRON-	PRP
cord-296347-fanlvxqs	132	8	MHC	MHC	NNP
cord-296347-fanlvxqs	132	9	products	product	NNS
cord-296347-fanlvxqs	132	10	on	on	IN
cord-296347-fanlvxqs	132	11	the	the	DT
cord-296347-fanlvxqs	132	12	surface	surface	NN
cord-296347-fanlvxqs	132	13	of	of	IN
cord-296347-fanlvxqs	132	14	the	the	DT
cord-296347-fanlvxqs	132	15	target	target	NN
cord-296347-fanlvxqs	132	16	cell	cell	NN
cord-296347-fanlvxqs	132	17	relieve	relieve	VBP
cord-296347-fanlvxqs	132	18	the	the	DT
cord-296347-fanlvxqs	132	19	inhibitory	inhibitory	JJ
cord-296347-fanlvxqs	132	20	signals	signal	NNS
cord-296347-fanlvxqs	132	21	and	and	CC
cord-296347-fanlvxqs	132	22	lead	lead	VBP
cord-296347-fanlvxqs	132	23	to	to	IN
cord-296347-fanlvxqs	132	24	NK	NK	NNP
cord-296347-fanlvxqs	132	25	cell	cell	NN
cord-296347-fanlvxqs	132	26	cytotoxicity	cytotoxicity	NN
cord-296347-fanlvxqs	132	27	,	,	,
cord-296347-fanlvxqs	132	28	resulting	result	VBG
cord-296347-fanlvxqs	132	29	in	in	IN
cord-296347-fanlvxqs	132	30	clearance	clearance	NN
cord-296347-fanlvxqs	132	31	of	of	IN
cord-296347-fanlvxqs	132	32	the	the	DT
cord-296347-fanlvxqs	132	33	virus	virus	NN
cord-296347-fanlvxqs	132	34	-	-	HYPH
cord-296347-fanlvxqs	132	35	infected	infect	VBN
cord-296347-fanlvxqs	132	36	or	or	CC
cord-296347-fanlvxqs	132	37	tumor	tumor	NN
cord-296347-fanlvxqs	132	38	cells	cell	NNS
cord-296347-fanlvxqs	132	39	.	.	.
cord-296347-fanlvxqs	133	1	NK	NK	NNP
cord-296347-fanlvxqs	133	2	cell	cell	NN
cord-296347-fanlvxqs	133	3	recognition	recognition	NN
cord-296347-fanlvxqs	133	4	has	have	VBZ
cord-296347-fanlvxqs	133	5	been	be	VBN
cord-296347-fanlvxqs	133	6	extensively	extensively	RB
cord-296347-fanlvxqs	133	7	revised	revise	VBN
cord-296347-fanlvxqs	133	8	and	and	CC
cord-296347-fanlvxqs	133	9	the	the	DT
cord-296347-fanlvxqs	133	10	reader	reader	NN
cord-296347-fanlvxqs	133	11	is	be	VBZ
cord-296347-fanlvxqs	133	12	referred	refer	VBN
cord-296347-fanlvxqs	133	13	to	to	IN
cord-296347-fanlvxqs	133	14	Backstrom	Backstrom	NNP
cord-296347-fanlvxqs	133	15	et	et	NNP
cord-296347-fanlvxqs	133	16	al	al	NNP
cord-296347-fanlvxqs	133	17	.	.	.
cord-296347-fanlvxqs	134	1	(	(	-LRB-
cord-296347-fanlvxqs	134	2	2004	2004	CD
cord-296347-fanlvxqs	134	3	)	)	-RRB-
cord-296347-fanlvxqs	134	4	;	;	:
cord-296347-fanlvxqs	134	5	Kumar	Kumar	NNP
cord-296347-fanlvxqs	134	6	and	and	CC
cord-296347-fanlvxqs	134	7	McNerne	McNerne	NNP
cord-296347-fanlvxqs	134	8	y	y	NNP
cord-296347-fanlvxqs	134	9	(	(	-LRB-
cord-296347-fanlvxqs	134	10	2005	2005	CD
cord-296347-fanlvxqs	134	11	)	)	-RRB-
cord-296347-fanlvxqs	134	12	;	;	:
cord-296347-fanlvxqs	134	13	and	and	CC
cord-296347-fanlvxqs	134	14	Lanier	Lanier	NNP
cord-296347-fanlvxqs	134	15	(	(	-LRB-
cord-296347-fanlvxqs	134	16	2005	2005	CD
cord-296347-fanlvxqs	134	17	)	)	-RRB-
cord-296347-fanlvxqs	134	18	.	.	.
cord-296347-fanlvxqs	135	1	There	there	EX
cord-296347-fanlvxqs	135	2	is	be	VBZ
cord-296347-fanlvxqs	135	3	an	an	DT
cord-296347-fanlvxqs	135	4	exception	exception	NN
cord-296347-fanlvxqs	135	5	to	to	IN
cord-296347-fanlvxqs	135	6	the	the	DT
cord-296347-fanlvxqs	135	7	rule	rule	NN
cord-296347-fanlvxqs	135	8	that	that	IN
cord-296347-fanlvxqs	135	9	the	the	DT
cord-296347-fanlvxqs	135	10	class	class	NN
cord-296347-fanlvxqs	135	11	I	-PRON-	PRP
cord-296347-fanlvxqs	135	12	MHC	MHC	NNP
cord-296347-fanlvxqs	135	13	pathway	pathway	NN
cord-296347-fanlvxqs	135	14	is	be	VBZ
cord-296347-fanlvxqs	135	15	devoted	devote	VBN
cord-296347-fanlvxqs	135	16	to	to	IN
cord-296347-fanlvxqs	135	17	display	display	NN
cord-296347-fanlvxqs	135	18	of	of	IN
cord-296347-fanlvxqs	135	19	peptide	peptide	NN
cord-296347-fanlvxqs	135	20	antigens	antigen	NNS
cord-296347-fanlvxqs	135	21	from	from	IN
cord-296347-fanlvxqs	135	22	endogenously	endogenously	RB
cord-296347-fanlvxqs	135	23	generated	generate	VBN
cord-296347-fanlvxqs	135	24	proteins	protein	NNS
cord-296347-fanlvxqs	135	25	:	:	:
cord-296347-fanlvxqs	135	26	the	the	DT
cord-296347-fanlvxqs	135	27	so	so	RB
cord-296347-fanlvxqs	135	28	-	-	HYPH
cord-296347-fanlvxqs	135	29	called	call	VBN
cord-296347-fanlvxqs	135	30	professional	professional	JJ
cord-296347-fanlvxqs	135	31	APCs	apc	NNS
cord-296347-fanlvxqs	135	32	,	,	,
cord-296347-fanlvxqs	135	33	DCs	dc	NNS
cord-296347-fanlvxqs	135	34	,	,	,
cord-296347-fanlvxqs	135	35	and	and	CC
cord-296347-fanlvxqs	135	36	macrophages	macrophage	NNS
cord-296347-fanlvxqs	135	37	can	can	MD
cord-296347-fanlvxqs	135	38	acquire	acquire	VB
cord-296347-fanlvxqs	135	39	and	and	CC
cord-296347-fanlvxqs	135	40	process	process	VB
cord-296347-fanlvxqs	135	41	exogenous	exogenous	JJ
cord-296347-fanlvxqs	135	42	material	material	NN
cord-296347-fanlvxqs	135	43	and	and	CC
cord-296347-fanlvxqs	135	44	present	present	VB
cord-296347-fanlvxqs	135	45	it	-PRON-	PRP
cord-296347-fanlvxqs	135	46	at	at	IN
cord-296347-fanlvxqs	135	47	the	the	DT
cord-296347-fanlvxqs	135	48	cell	cell	NN
cord-296347-fanlvxqs	135	49	surface	surface	NN
cord-296347-fanlvxqs	135	50	in	in	IN
cord-296347-fanlvxqs	135	51	class	class	NN
cord-296347-fanlvxqs	135	52	I	-PRON-	PRP
cord-296347-fanlvxqs	135	53	MHC	MHC	NNP
cord-296347-fanlvxqs	135	54	products	product	NNS
cord-296347-fanlvxqs	135	55	,	,	,
cord-296347-fanlvxqs	135	56	a	a	DT
cord-296347-fanlvxqs	135	57	process	process	NN
cord-296347-fanlvxqs	135	58	called	call	VBN
cord-296347-fanlvxqs	135	59	cross	cross	NN
cord-296347-fanlvxqs	135	60	-	-	NN
cord-296347-fanlvxqs	135	61	presentation	presentation	NN
cord-296347-fanlvxqs	135	62	.	.	.
cord-296347-fanlvxqs	136	1	Cross	cross	NN
cord-296347-fanlvxqs	136	2	-	-	NN
cord-296347-fanlvxqs	136	3	presentation	presentation	NN
cord-296347-fanlvxqs	136	4	allows	allow	VBZ
cord-296347-fanlvxqs	136	5	noninfected	noninfected	JJ
cord-296347-fanlvxqs	136	6	professional	professional	JJ
cord-296347-fanlvxqs	136	7	APCs	apc	NNS
cord-296347-fanlvxqs	136	8	to	to	IN
cord-296347-fanlvxqs	136	9	prime	prime	JJ
cord-296347-fanlvxqs	136	10	naïve	naïve	JJ
cord-296347-fanlvxqs	136	11	T	t	NN
cord-296347-fanlvxqs	136	12	cells	cell	NNS
cord-296347-fanlvxqs	136	13	with	with	IN
cord-296347-fanlvxqs	136	14	pathogen	pathogen	NN
cord-296347-fanlvxqs	136	15	-	-	HYPH
cord-296347-fanlvxqs	136	16	or	or	CC
cord-296347-fanlvxqs	136	17	tumor	tumor	NN
cord-296347-fanlvxqs	136	18	-	-	HYPH
cord-296347-fanlvxqs	136	19	derived	derive	VBN
cord-296347-fanlvxqs	136	20	peptides	peptide	NNS
cord-296347-fanlvxqs	136	21	acquired	acquire	VBN
cord-296347-fanlvxqs	136	22	through	through	IN
cord-296347-fanlvxqs	136	23	endocytosis	endocytosis	NN
cord-296347-fanlvxqs	136	24	of	of	IN
cord-296347-fanlvxqs	136	25	infected	infected	JJ
cord-296347-fanlvxqs	136	26	cells	cell	NNS
cord-296347-fanlvxqs	136	27	/	/	SYM
cord-296347-fanlvxqs	136	28	cell	cell	NN
cord-296347-fanlvxqs	136	29	remnants	remnant	NNS
cord-296347-fanlvxqs	136	30	.	.	.
cord-296347-fanlvxqs	137	1	This	this	DT
cord-296347-fanlvxqs	137	2	'	'	``
cord-296347-fanlvxqs	137	3	'	'	``
cord-296347-fanlvxqs	137	4	cross	cross	NN
cord-296347-fanlvxqs	137	5	-	-	JJ
cord-296347-fanlvxqs	137	6	priming	priming	NN
cord-296347-fanlvxqs	137	7	'	'	''
cord-296347-fanlvxqs	137	8	'	'	''
cord-296347-fanlvxqs	137	9	is	be	VBZ
cord-296347-fanlvxqs	137	10	essential	essential	JJ
cord-296347-fanlvxqs	137	11	for	for	IN
cord-296347-fanlvxqs	137	12	development	development	NN
cord-296347-fanlvxqs	137	13	of	of	IN
cord-296347-fanlvxqs	137	14	CD8	CD8	NNP
cord-296347-fanlvxqs	137	15	þ	þ	NNP
cord-296347-fanlvxqs	137	16	T	T	NNP
cord-296347-fanlvxqs	137	17	cell	cell	NN
cord-296347-fanlvxqs	137	18	immunity	immunity	NN
cord-296347-fanlvxqs	137	19	to	to	IN
cord-296347-fanlvxqs	137	20	viruses	virus	NNS
cord-296347-fanlvxqs	137	21	and	and	CC
cord-296347-fanlvxqs	137	22	tumors	tumor	NNS
cord-296347-fanlvxqs	137	23	in	in	IN
cord-296347-fanlvxqs	137	24	vivo	vivo	NN
cord-296347-fanlvxqs	137	25	,	,	,
cord-296347-fanlvxqs	137	26	since	since	IN
cord-296347-fanlvxqs	137	27	only	only	JJ
cord-296347-fanlvxqs	137	28	professional	professional	JJ
cord-296347-fanlvxqs	137	29	APCs	apc	NNS
cord-296347-fanlvxqs	137	30	can	can	MD
cord-296347-fanlvxqs	137	31	present	present	VB
cord-296347-fanlvxqs	137	32	viral	viral	JJ
cord-296347-fanlvxqs	137	33	/	/	SYM
cord-296347-fanlvxqs	137	34	tumor	tumor	NN
cord-296347-fanlvxqs	137	35	antigens	antigen	NNS
cord-296347-fanlvxqs	137	36	in	in	IN
cord-296347-fanlvxqs	137	37	the	the	DT
cord-296347-fanlvxqs	137	38	context	context	NN
cord-296347-fanlvxqs	137	39	of	of	IN
cord-296347-fanlvxqs	137	40	class	class	NN
cord-296347-fanlvxqs	137	41	I	-PRON-	PRP
cord-296347-fanlvxqs	137	42	MHC	MHC	NNP
cord-296347-fanlvxqs	137	43	products	product	NNS
cord-296347-fanlvxqs	137	44	without	without	IN
cord-296347-fanlvxqs	137	45	being	be	VBG
cord-296347-fanlvxqs	137	46	themselves	-PRON-	PRP
cord-296347-fanlvxqs	137	47	infected	infect	VBN
cord-296347-fanlvxqs	137	48	/	/	SYM
cord-296347-fanlvxqs	137	49	tumorigenic	tumorigenic	NNP
cord-296347-fanlvxqs	137	50	.	.	.
cord-296347-fanlvxqs	138	1	There	there	EX
cord-296347-fanlvxqs	138	2	is	be	VBZ
cord-296347-fanlvxqs	138	3	considerable	considerable	JJ
cord-296347-fanlvxqs	138	4	controversy	controversy	NN
cord-296347-fanlvxqs	138	5	as	as	IN
cord-296347-fanlvxqs	138	6	to	to	IN
cord-296347-fanlvxqs	138	7	the	the	DT
cord-296347-fanlvxqs	138	8	exact	exact	JJ
cord-296347-fanlvxqs	138	9	nature	nature	NN
cord-296347-fanlvxqs	138	10	of	of	IN
cord-296347-fanlvxqs	138	11	the	the	DT
cord-296347-fanlvxqs	138	12	antigen	antigen	NN
cord-296347-fanlvxqs	138	13	acquired	acquire	VBN
cord-296347-fanlvxqs	138	14	and	and	CC
cord-296347-fanlvxqs	138	15	modes	mode	NNS
cord-296347-fanlvxqs	138	16	of	of	IN
cord-296347-fanlvxqs	138	17	antigen	antigen	NN
cord-296347-fanlvxqs	138	18	acquisition	acquisition	NN
cord-296347-fanlvxqs	138	19	,	,	,
cord-296347-fanlvxqs	138	20	as	as	RB
cord-296347-fanlvxqs	138	21	well	well	RB
cord-296347-fanlvxqs	138	22	as	as	IN
cord-296347-fanlvxqs	138	23	the	the	DT
cord-296347-fanlvxqs	138	24	intracellular	intracellular	JJ
cord-296347-fanlvxqs	138	25	mechanisms	mechanism	NNS
cord-296347-fanlvxqs	138	26	leading	lead	VBG
cord-296347-fanlvxqs	138	27	to	to	IN
cord-296347-fanlvxqs	138	28	cross	cross	NN
cord-296347-fanlvxqs	138	29	-	-	NN
cord-296347-fanlvxqs	138	30	presentation	presentation	NN
cord-296347-fanlvxqs	138	31	and	and	CC
cord-296347-fanlvxqs	138	32	the	the	DT
cord-296347-fanlvxqs	138	33	subsets	subset	NNS
cord-296347-fanlvxqs	138	34	of	of	IN
cord-296347-fanlvxqs	138	35	APCs	apc	NNS
cord-296347-fanlvxqs	138	36	endowed	endow	VBN
cord-296347-fanlvxqs	138	37	with	with	IN
cord-296347-fanlvxqs	138	38	this	this	DT
cord-296347-fanlvxqs	138	39	property	property	NN
cord-296347-fanlvxqs	138	40	(	(	-LRB-
cord-296347-fanlvxqs	138	41	Cresswell	Cresswell	NNP
cord-296347-fanlvxqs	138	42	et	et	NNP
cord-296347-fanlvxqs	138	43	al	al	NNP
cord-296347-fanlvxqs	138	44	.	.	NNP
cord-296347-fanlvxqs	138	45	,	,	,
cord-296347-fanlvxqs	138	46	2005	2005	CD
cord-296347-fanlvxqs	138	47	;	;	:
cord-296347-fanlvxqs	138	48	Groothuis	Groothuis	NNP
cord-296347-fanlvxqs	138	49	and	and	CC
cord-296347-fanlvxqs	138	50	Neefjes	Neefjes	NNP
cord-296347-fanlvxqs	138	51	,	,	,
cord-296347-fanlvxqs	138	52	2005	2005	CD
cord-296347-fanlvxqs	138	53	;	;	:
cord-296347-fanlvxqs	138	54	Guermonprez	Guermonprez	NNP
cord-296347-fanlvxqs	138	55	and	and	CC
cord-296347-fanlvxqs	138	56	Amigorena	Amigorena	NNP
cord-296347-fanlvxqs	138	57	,	,	,
cord-296347-fanlvxqs	138	58	2005	2005	CD
cord-296347-fanlvxqs	138	59	;	;	:
cord-296347-fanlvxqs	138	60	Jutras	Jutras	NNP
cord-296347-fanlvxqs	138	61	and	and	CC
cord-296347-fanlvxqs	138	62	Desjardins	Desjardins	NNP
cord-296347-fanlvxqs	138	63	,	,	,
cord-296347-fanlvxqs	138	64	2005	2005	CD
cord-296347-fanlvxqs	138	65	;	;	:
cord-296347-fanlvxqs	138	66	Shen	Shen	NNP
cord-296347-fanlvxqs	138	67	and	and	CC
cord-296347-fanlvxqs	138	68	Rock	Rock	NNP
cord-296347-fanlvxqs	138	69	,	,	,
cord-296347-fanlvxqs	138	70	2006	2006	CD
cord-296347-fanlvxqs	138	71	)	)	-RRB-
cord-296347-fanlvxqs	138	72	.	.	.
cord-296347-fanlvxqs	139	1	This	this	DT
cord-296347-fanlvxqs	139	2	controversy	controversy	NN
cord-296347-fanlvxqs	139	3	is	be	VBZ
cord-296347-fanlvxqs	139	4	,	,	,
cord-296347-fanlvxqs	139	5	however	however	RB
cord-296347-fanlvxqs	139	6	,	,	,
cord-296347-fanlvxqs	139	7	beyond	beyond	IN
cord-296347-fanlvxqs	139	8	the	the	DT
cord-296347-fanlvxqs	139	9	scope	scope	NN
cord-296347-fanlvxqs	139	10	of	of	IN
cord-296347-fanlvxqs	139	11	this	this	DT
cord-296347-fanlvxqs	139	12	discussion	discussion	NN
cord-296347-fanlvxqs	139	13	.	.	.
cord-296347-fanlvxqs	140	1	The	the	DT
cord-296347-fanlvxqs	140	2	class	class	NN
cord-296347-fanlvxqs	140	3	II	II	NNP
cord-296347-fanlvxqs	140	4	MHC	MHC	NNP
cord-296347-fanlvxqs	140	5	antigen	antigen	NN
cord-296347-fanlvxqs	140	6	presentation	presentation	NN
cord-296347-fanlvxqs	140	7	pathway	pathway	NN
cord-296347-fanlvxqs	140	8	deals	deal	NNS
cord-296347-fanlvxqs	140	9	with	with	IN
cord-296347-fanlvxqs	140	10	antigens	antigen	NNS
cord-296347-fanlvxqs	140	11	that	that	WDT
cord-296347-fanlvxqs	140	12	reside	reside	VBP
cord-296347-fanlvxqs	140	13	in	in	IN
cord-296347-fanlvxqs	140	14	extracellular	extracellular	JJ
cord-296347-fanlvxqs	140	15	space	space	NN
cord-296347-fanlvxqs	140	16	and	and	CC
cord-296347-fanlvxqs	140	17	are	be	VBP
cord-296347-fanlvxqs	140	18	internalized	internalize	VBN
cord-296347-fanlvxqs	140	19	into	into	IN
cord-296347-fanlvxqs	140	20	the	the	DT
cord-296347-fanlvxqs	140	21	endolysosomal	endolysosomal	JJ
cord-296347-fanlvxqs	140	22	pathway	pathway	NN
cord-296347-fanlvxqs	140	23	.	.	.
cord-296347-fanlvxqs	141	1	All	all	DT
cord-296347-fanlvxqs	141	2	mammalian	mammalian	JJ
cord-296347-fanlvxqs	141	3	cells	cell	NNS
cord-296347-fanlvxqs	141	4	internalize	internalize	VBP
cord-296347-fanlvxqs	141	5	their	-PRON-	PRP$
cord-296347-fanlvxqs	141	6	own	own	JJ
cord-296347-fanlvxqs	141	7	cell	cell	NN
cord-296347-fanlvxqs	141	8	surface	surface	NN
cord-296347-fanlvxqs	141	9	proteins	protein	NNS
cord-296347-fanlvxqs	141	10	by	by	IN
cord-296347-fanlvxqs	141	11	constitutive	constitutive	JJ
cord-296347-fanlvxqs	141	12	endocytosis	endocytosis	NN
cord-296347-fanlvxqs	141	13	.	.	.
cord-296347-fanlvxqs	142	1	In	in	IN
cord-296347-fanlvxqs	142	2	class	class	NN
cord-296347-fanlvxqs	142	3	II	II	NNP
cord-296347-fanlvxqs	142	4	MHC	MHC	NNP
cord-296347-fanlvxqs	142	5	þ	þ	CD
cord-296347-fanlvxqs	142	6	cells	cell	NNS
cord-296347-fanlvxqs	142	7	,	,	,
cord-296347-fanlvxqs	142	8	this	this	DT
cord-296347-fanlvxqs	142	9	allows	allow	VBZ
cord-296347-fanlvxqs	142	10	class	class	NN
cord-296347-fanlvxqs	142	11	II	II	NNP
cord-296347-fanlvxqs	142	12	MHC	MHC	NNP
cord-296347-fanlvxqs	142	13	access	access	NN
cord-296347-fanlvxqs	142	14	to	to	IN
cord-296347-fanlvxqs	142	15	self	self	NN
cord-296347-fanlvxqs	142	16	-	-	HYPH
cord-296347-fanlvxqs	142	17	proteins	protein	NNS
cord-296347-fanlvxqs	142	18	as	as	IN
cord-296347-fanlvxqs	142	19	a	a	DT
cord-296347-fanlvxqs	142	20	source	source	NN
cord-296347-fanlvxqs	142	21	of	of	IN
cord-296347-fanlvxqs	142	22	peptides	peptide	NNS
cord-296347-fanlvxqs	142	23	.	.	.
cord-296347-fanlvxqs	143	1	Professional	professional	JJ
cord-296347-fanlvxqs	143	2	APCs	apc	NNS
cord-296347-fanlvxqs	143	3	,	,	,
cord-296347-fanlvxqs	143	4	such	such	JJ
cord-296347-fanlvxqs	143	5	as	as	IN
cord-296347-fanlvxqs	143	6	B	b	NN
cord-296347-fanlvxqs	143	7	cells	cell	NNS
cord-296347-fanlvxqs	143	8	,	,	,
cord-296347-fanlvxqs	143	9	macrophages	macrophage	NNS
cord-296347-fanlvxqs	143	10	,	,	,
cord-296347-fanlvxqs	143	11	and	and	CC
cord-296347-fanlvxqs	143	12	DCs	DCs	NNP
cord-296347-fanlvxqs	143	13	,	,	,
cord-296347-fanlvxqs	143	14	also	also	RB
cord-296347-fanlvxqs	143	15	engage	engage	VB
cord-296347-fanlvxqs	143	16	in	in	IN
cord-296347-fanlvxqs	143	17	receptor	receptor	NN
cord-296347-fanlvxqs	143	18	-	-	HYPH
cord-296347-fanlvxqs	143	19	mediated	mediate	VBN
cord-296347-fanlvxqs	143	20	endocytosis	endocytosis	NN
cord-296347-fanlvxqs	143	21	to	to	TO
cord-296347-fanlvxqs	143	22	acquire	acquire	VB
cord-296347-fanlvxqs	143	23	extracellular	extracellular	JJ
cord-296347-fanlvxqs	143	24	antigen	antigen	NN
cord-296347-fanlvxqs	143	25	:	:	:
cord-296347-fanlvxqs	143	26	the	the	DT
cord-296347-fanlvxqs	143	27	antigen	antigen	NN
cord-296347-fanlvxqs	143	28	from	from	IN
cord-296347-fanlvxqs	143	29	the	the	DT
cord-296347-fanlvxqs	143	30	extracellular	extracellular	JJ
cord-296347-fanlvxqs	143	31	milieu	milieu	NN
cord-296347-fanlvxqs	143	32	is	be	VBZ
cord-296347-fanlvxqs	143	33	bound	bind	VBN
cord-296347-fanlvxqs	143	34	by	by	IN
cord-296347-fanlvxqs	143	35	cell	cell	NN
cord-296347-fanlvxqs	143	36	surface	surface	NN
cord-296347-fanlvxqs	143	37	receptors	receptor	NNS
cord-296347-fanlvxqs	143	38	,	,	,
cord-296347-fanlvxqs	143	39	internalized	internalize	VBN
cord-296347-fanlvxqs	143	40	,	,	,
cord-296347-fanlvxqs	143	41	and	and	CC
cord-296347-fanlvxqs	143	42	delivered	deliver	VBN
cord-296347-fanlvxqs	143	43	to	to	IN
cord-296347-fanlvxqs	143	44	the	the	DT
cord-296347-fanlvxqs	143	45	class	class	NN
cord-296347-fanlvxqs	143	46	II	II	NNP
cord-296347-fanlvxqs	143	47	MHC	MHC	NNP
cord-296347-fanlvxqs	143	48	antigen	antigen	NN
cord-296347-fanlvxqs	143	49	processing	processing	NN
cord-296347-fanlvxqs	143	50	machinery	machinery	NN
cord-296347-fanlvxqs	143	51	.	.	.
cord-296347-fanlvxqs	144	1	Antibodies	antibody	NNS
cord-296347-fanlvxqs	144	2	,	,	,
cord-296347-fanlvxqs	144	3	complement	complement	VB
cord-296347-fanlvxqs	144	4	system	system	NN
cord-296347-fanlvxqs	144	5	factors	factor	NNS
cord-296347-fanlvxqs	144	6	,	,	,
cord-296347-fanlvxqs	144	7	and	and	CC
cord-296347-fanlvxqs	144	8	common	common	JJ
cord-296347-fanlvxqs	144	9	bacterial	bacterial	JJ
cord-296347-fanlvxqs	144	10	or	or	CC
cord-296347-fanlvxqs	144	11	viral	viral	JJ
cord-296347-fanlvxqs	144	12	components	component	NNS
cord-296347-fanlvxqs	144	13	that	that	WDT
cord-296347-fanlvxqs	144	14	coat	coat	VBP
cord-296347-fanlvxqs	144	15	the	the	DT
cord-296347-fanlvxqs	144	16	surface	surface	NN
cord-296347-fanlvxqs	144	17	of	of	IN
cord-296347-fanlvxqs	144	18	pathogens	pathogen	NNS
cord-296347-fanlvxqs	144	19	or	or	CC
cord-296347-fanlvxqs	144	20	their	-PRON-	PRP$
cord-296347-fanlvxqs	144	21	toxic	toxic	JJ
cord-296347-fanlvxqs	144	22	products	product	NNS
cord-296347-fanlvxqs	144	23	bind	bind	VBP
cord-296347-fanlvxqs	144	24	receptors	receptor	NNS
cord-296347-fanlvxqs	144	25	on	on	IN
cord-296347-fanlvxqs	144	26	APCs	apc	NNS
cord-296347-fanlvxqs	144	27	that	that	WDT
cord-296347-fanlvxqs	144	28	allow	allow	VBP
cord-296347-fanlvxqs	144	29	them	-PRON-	PRP
cord-296347-fanlvxqs	144	30	to	to	TO
cord-296347-fanlvxqs	144	31	recognize	recognize	VB
cord-296347-fanlvxqs	144	32	and	and	CC
cord-296347-fanlvxqs	144	33	internalize	internalize	VB
cord-296347-fanlvxqs	144	34	this	this	DT
cord-296347-fanlvxqs	144	35	foreign	foreign	JJ
cord-296347-fanlvxqs	144	36	material	material	NN
cord-296347-fanlvxqs	144	37	.	.	.
cord-296347-fanlvxqs	145	1	Of	of	IN
cord-296347-fanlvxqs	145	2	the	the	DT
cord-296347-fanlvxqs	145	3	many	many	JJ
cord-296347-fanlvxqs	145	4	receptors	receptor	NNS
cord-296347-fanlvxqs	145	5	used	use	VBN
cord-296347-fanlvxqs	145	6	by	by	IN
cord-296347-fanlvxqs	145	7	professional	professional	JJ
cord-296347-fanlvxqs	145	8	APCs	apc	NNS
cord-296347-fanlvxqs	145	9	for	for	IN
cord-296347-fanlvxqs	145	10	this	this	DT
cord-296347-fanlvxqs	145	11	purpose	purpose	NN
cord-296347-fanlvxqs	145	12	,	,	,
cord-296347-fanlvxqs	145	13	the	the	DT
cord-296347-fanlvxqs	145	14	mannose	mannose	NN
cord-296347-fanlvxqs	145	15	receptor	receptor	NN
cord-296347-fanlvxqs	145	16	,	,	,
cord-296347-fanlvxqs	145	17	which	which	WDT
cord-296347-fanlvxqs	145	18	recognizes	recognize	VBZ
cord-296347-fanlvxqs	145	19	mannose	mannose	NN
cord-296347-fanlvxqs	145	20	residues	residue	NNS
cord-296347-fanlvxqs	145	21	and	and	CC
cord-296347-fanlvxqs	145	22	glycoproteins	glycoprotein	NNS
cord-296347-fanlvxqs	145	23	on	on	IN
cord-296347-fanlvxqs	145	24	viral	viral	JJ
cord-296347-fanlvxqs	145	25	and	and	CC
cord-296347-fanlvxqs	145	26	bacterial	bacterial	JJ
cord-296347-fanlvxqs	145	27	products	product	NNS
cord-296347-fanlvxqs	145	28	,	,	,
cord-296347-fanlvxqs	145	29	and	and	CC
cord-296347-fanlvxqs	145	30	the	the	DT
cord-296347-fanlvxqs	145	31	scavenger	scavenger	NN
cord-296347-fanlvxqs	145	32	receptor	receptor	NN
cord-296347-fanlvxqs	145	33	,	,	,
cord-296347-fanlvxqs	145	34	which	which	WDT
cord-296347-fanlvxqs	145	35	recognizes	recognize	VBZ
cord-296347-fanlvxqs	145	36	very	very	RB
cord-296347-fanlvxqs	145	37	promiscuously	promiscuously	RB
cord-296347-fanlvxqs	145	38	many	many	JJ
cord-296347-fanlvxqs	145	39	different	different	JJ
cord-296347-fanlvxqs	145	40	classes	class	NNS
cord-296347-fanlvxqs	145	41	of	of	IN
cord-296347-fanlvxqs	145	42	macromolecules	macromolecule	NNS
cord-296347-fanlvxqs	145	43	,	,	,
cord-296347-fanlvxqs	145	44	are	be	VBP
cord-296347-fanlvxqs	145	45	among	among	IN
cord-296347-fanlvxqs	145	46	the	the	DT
cord-296347-fanlvxqs	145	47	most	most	RBS
cord-296347-fanlvxqs	145	48	important	important	JJ
cord-296347-fanlvxqs	145	49	.	.	.
cord-296347-fanlvxqs	146	1	Professional	professional	JJ
cord-296347-fanlvxqs	146	2	APCs	apc	NNS
cord-296347-fanlvxqs	146	3	also	also	RB
cord-296347-fanlvxqs	146	4	have	have	VBP
cord-296347-fanlvxqs	146	5	complement	complement	JJ
cord-296347-fanlvxqs	146	6	receptors	receptor	NNS
cord-296347-fanlvxqs	146	7	and	and	CC
cord-296347-fanlvxqs	146	8	receptors	receptor	NNS
cord-296347-fanlvxqs	146	9	for	for	IN
cord-296347-fanlvxqs	146	10	the	the	DT
cord-296347-fanlvxqs	146	11	Fc	Fc	NNP
cord-296347-fanlvxqs	146	12	region	region	NN
cord-296347-fanlvxqs	146	13	of	of	IN
cord-296347-fanlvxqs	146	14	antibodies	antibody	NNS
cord-296347-fanlvxqs	146	15	,	,	,
cord-296347-fanlvxqs	146	16	the	the	DT
cord-296347-fanlvxqs	146	17	Fc	Fc	NNP
cord-296347-fanlvxqs	146	18	receptors	receptor	NNS
cord-296347-fanlvxqs	146	19	,	,	,
cord-296347-fanlvxqs	146	20	which	which	WDT
cord-296347-fanlvxqs	146	21	can	can	MD
cord-296347-fanlvxqs	146	22	assist	assist	VB
cord-296347-fanlvxqs	146	23	in	in	IN
cord-296347-fanlvxqs	146	24	the	the	DT
cord-296347-fanlvxqs	146	25	acquisition	acquisition	NN
cord-296347-fanlvxqs	146	26	of	of	IN
cord-296347-fanlvxqs	146	27	opsonized	opsonized	JJ
cord-296347-fanlvxqs	146	28	antigen	antigen	NN
cord-296347-fanlvxqs	146	29	and	and	CC
cord-296347-fanlvxqs	146	30	in	in	IN
cord-296347-fanlvxqs	146	31	its	-PRON-	PRP$
cord-296347-fanlvxqs	146	32	delivery	delivery	NN
cord-296347-fanlvxqs	146	33	to	to	IN
cord-296347-fanlvxqs	146	34	the	the	DT
cord-296347-fanlvxqs	146	35	proper	proper	JJ
cord-296347-fanlvxqs	146	36	intracellular	intracellular	JJ
cord-296347-fanlvxqs	146	37	destination	destination	NN
cord-296347-fanlvxqs	146	38	.	.	.
cord-296347-fanlvxqs	147	1	B	b	NN
cord-296347-fanlvxqs	147	2	cells	cell	NNS
cord-296347-fanlvxqs	147	3	can	can	MD
cord-296347-fanlvxqs	147	4	also	also	RB
cord-296347-fanlvxqs	147	5	use	use	VB
cord-296347-fanlvxqs	147	6	their	-PRON-	PRP$
cord-296347-fanlvxqs	147	7	surface	surface	NN
cord-296347-fanlvxqs	147	8	immunoglobulin	immunoglobulin	NN
cord-296347-fanlvxqs	147	9	or	or	CC
cord-296347-fanlvxqs	147	10	BCR	bcr	NN
cord-296347-fanlvxqs	147	11	,	,	,
cord-296347-fanlvxqs	147	12	to	to	TO
cord-296347-fanlvxqs	147	13	acquire	acquire	VB
cord-296347-fanlvxqs	147	14	antigen	antigen	NNP
cord-296347-fanlvxqs	147	15	(	(	-LRB-
cord-296347-fanlvxqs	147	16	Bryant	Bryant	NNP
cord-296347-fanlvxqs	147	17	and	and	CC
cord-296347-fanlvxqs	147	18	Ploegh	Ploegh	NNP
cord-296347-fanlvxqs	147	19	,	,	,
cord-296347-fanlvxqs	147	20	2004	2004	CD
cord-296347-fanlvxqs	147	21	;	;	:
cord-296347-fanlvxqs	147	22	Cresswell	Cresswell	NNP
cord-296347-fanlvxqs	147	23	,	,	,
cord-296347-fanlvxqs	147	24	1994	1994	CD
cord-296347-fanlvxqs	147	25	;	;	:
cord-296347-fanlvxqs	147	26	Kim	Kim	NNP
cord-296347-fanlvxqs	147	27	et	et	NNP
cord-296347-fanlvxqs	147	28	al	al	NNP
cord-296347-fanlvxqs	147	29	.	.	NNP
cord-296347-fanlvxqs	147	30	,	,	,
cord-296347-fanlvxqs	147	31	2006c	2006c	CD
cord-296347-fanlvxqs	147	32	)	)	-RRB-
cord-296347-fanlvxqs	147	33	.	.	.
cord-296347-fanlvxqs	148	1	Class	Class	NNP
cord-296347-fanlvxqs	148	2	II	II	NNP
cord-296347-fanlvxqs	148	3	MHC	MHC	NNP
cord-296347-fanlvxqs	148	4	loading	load	VBG
cord-296347-fanlvxqs	148	5	with	with	IN
cord-296347-fanlvxqs	148	6	antigenic	antigenic	JJ
cord-296347-fanlvxqs	148	7	peptides	peptide	NNS
cord-296347-fanlvxqs	148	8	takes	take	VBZ
cord-296347-fanlvxqs	148	9	place	place	NN
cord-296347-fanlvxqs	148	10	mostly	mostly	RB
cord-296347-fanlvxqs	148	11	in	in	IN
cord-296347-fanlvxqs	148	12	the	the	DT
cord-296347-fanlvxqs	148	13	endocytic	endocytic	JJ
cord-296347-fanlvxqs	148	14	vesicles	vesicle	NNS
cord-296347-fanlvxqs	148	15	of	of	IN
cord-296347-fanlvxqs	148	16	professional	professional	JJ
cord-296347-fanlvxqs	148	17	APCs	apc	NNS
cord-296347-fanlvxqs	148	18	.	.	.
cord-296347-fanlvxqs	149	1	Class	Class	NNP
cord-296347-fanlvxqs	149	2	II	II	NNP
cord-296347-fanlvxqs	149	3	MHC	MHC	NNP
cord-296347-fanlvxqs	149	4	ab	ab	NNS
cord-296347-fanlvxqs	149	5	dimers	dimer	NNS
cord-296347-fanlvxqs	149	6	assemble	assemble	VBP
cord-296347-fanlvxqs	149	7	in	in	IN
cord-296347-fanlvxqs	149	8	the	the	DT
cord-296347-fanlvxqs	149	9	ER	er	NN
cord-296347-fanlvxqs	149	10	and	and	CC
cord-296347-fanlvxqs	149	11	associate	associate	VB
cord-296347-fanlvxqs	149	12	with	with	IN
cord-296347-fanlvxqs	149	13	the	the	DT
cord-296347-fanlvxqs	149	14	chaperone	chaperone	NN
cord-296347-fanlvxqs	149	15	invariant	invariant	JJ
cord-296347-fanlvxqs	149	16	chain	chain	NN
cord-296347-fanlvxqs	149	17	(	(	-LRB-
cord-296347-fanlvxqs	149	18	Ii	Ii	NNP
cord-296347-fanlvxqs	149	19	)	)	-RRB-
cord-296347-fanlvxqs	149	20	,	,	,
cord-296347-fanlvxqs	149	21	which	which	WDT
cord-296347-fanlvxqs	149	22	inserts	insert	VBZ
cord-296347-fanlvxqs	149	23	its	-PRON-	PRP$
cord-296347-fanlvxqs	149	24	class	class	NN
cord-296347-fanlvxqs	149	25	II	II	NNP
cord-296347-fanlvxqs	149	26	MHC	MHC	NNP
cord-296347-fanlvxqs	149	27	-	-	HYPH
cord-296347-fanlvxqs	149	28	associated	associate	VBN
cord-296347-fanlvxqs	149	29	Ii	Ii	NNP
cord-296347-fanlvxqs	149	30	peptide	peptide	NN
cord-296347-fanlvxqs	149	31	(	(	-LRB-
cord-296347-fanlvxqs	149	32	CLIP	CLIP	NNP
cord-296347-fanlvxqs	149	33	)	)	-RRB-
cord-296347-fanlvxqs	149	34	portion	portion	NN
cord-296347-fanlvxqs	149	35	in	in	IN
cord-296347-fanlvxqs	149	36	the	the	DT
cord-296347-fanlvxqs	149	37	peptide	peptide	NN
cord-296347-fanlvxqs	149	38	-	-	HYPH
cord-296347-fanlvxqs	149	39	binding	bind	VBG
cord-296347-fanlvxqs	149	40	groove	groove	NN
cord-296347-fanlvxqs	149	41	of	of	IN
cord-296347-fanlvxqs	149	42	the	the	DT
cord-296347-fanlvxqs	149	43	ab	ab	NNP
cord-296347-fanlvxqs	149	44	dimer	dimer	NNP
cord-296347-fanlvxqs	149	45	,	,	,
cord-296347-fanlvxqs	149	46	preventing	prevent	VBG
cord-296347-fanlvxqs	149	47	its	-PRON-	PRP$
cord-296347-fanlvxqs	149	48	premature	premature	JJ
cord-296347-fanlvxqs	149	49	(	(	-LRB-
cord-296347-fanlvxqs	149	50	prelysosomal	prelysosomal	NNP
cord-296347-fanlvxqs	149	51	)	)	-RRB-
cord-296347-fanlvxqs	149	52	loading	loading	NN
cord-296347-fanlvxqs	149	53	.	.	.
cord-296347-fanlvxqs	150	1	Ii	Ii	NNP
cord-296347-fanlvxqs	150	2	is	be	VBZ
cord-296347-fanlvxqs	150	3	also	also	RB
cord-296347-fanlvxqs	150	4	important	important	JJ
cord-296347-fanlvxqs	150	5	for	for	IN
cord-296347-fanlvxqs	150	6	correct	correct	JJ
cord-296347-fanlvxqs	150	7	assembly	assembly	NN
cord-296347-fanlvxqs	150	8	and	and	CC
cord-296347-fanlvxqs	150	9	transport	transport	NN
cord-296347-fanlvxqs	150	10	of	of	IN
cord-296347-fanlvxqs	150	11	class	class	NN
cord-296347-fanlvxqs	150	12	II	II	NNP
cord-296347-fanlvxqs	150	13	MHC	MHC	NNP
cord-296347-fanlvxqs	150	14	in	in	IN
cord-296347-fanlvxqs	150	15	the	the	DT
cord-296347-fanlvxqs	150	16	endocytic	endocytic	JJ
cord-296347-fanlvxqs	150	17	pathway	pathway	NN
cord-296347-fanlvxqs	150	18	.	.	.
cord-296347-fanlvxqs	151	1	Further	further	JJ
cord-296347-fanlvxqs	151	2	class	class	NN
cord-296347-fanlvxqs	151	3	II	II	NNP
cord-296347-fanlvxqs	151	4	MHC	MHC	NNP
cord-296347-fanlvxqs	151	5	maturation	maturation	NN
cord-296347-fanlvxqs	151	6	and	and	CC
cord-296347-fanlvxqs	151	7	peptide	peptide	NN
cord-296347-fanlvxqs	151	8	loading	loading	NN
cord-296347-fanlvxqs	151	9	takes	take	VBZ
cord-296347-fanlvxqs	151	10	place	place	NN
cord-296347-fanlvxqs	151	11	in	in	IN
cord-296347-fanlvxqs	151	12	acidified	acidified	JJ
cord-296347-fanlvxqs	151	13	compartments	compartment	NNS
cord-296347-fanlvxqs	151	14	of	of	IN
cord-296347-fanlvxqs	151	15	the	the	DT
cord-296347-fanlvxqs	151	16	endolysosomal	endolysosomal	JJ
cord-296347-fanlvxqs	151	17	pathway	pathway	NN
cord-296347-fanlvxqs	151	18	of	of	IN
cord-296347-fanlvxqs	151	19	APCs	apc	NNS
cord-296347-fanlvxqs	151	20	,	,	,
cord-296347-fanlvxqs	151	21	since	since	IN
cord-296347-fanlvxqs	151	22	low	low	JJ
cord-296347-fanlvxqs	151	23	pH	pH	NNP
cord-296347-fanlvxqs	151	24	favors	favor	VBZ
cord-296347-fanlvxqs	151	25	an	an	DT
cord-296347-fanlvxqs	151	26	'	'	``
cord-296347-fanlvxqs	151	27	'	'	``
cord-296347-fanlvxqs	151	28	open	open	JJ
cord-296347-fanlvxqs	151	29	'	'	''
cord-296347-fanlvxqs	151	30	'	'	''
cord-296347-fanlvxqs	151	31	conformation	conformation	NN
cord-296347-fanlvxqs	151	32	of	of	IN
cord-296347-fanlvxqs	151	33	the	the	DT
cord-296347-fanlvxqs	151	34	class	class	NN
cord-296347-fanlvxqs	151	35	II	II	NNP
cord-296347-fanlvxqs	151	36	MHC	MHC	NNP
cord-296347-fanlvxqs	151	37	molecule	molecule	NN
cord-296347-fanlvxqs	151	38	and	and	CC
cord-296347-fanlvxqs	151	39	hence	hence	RB
cord-296347-fanlvxqs	151	40	peptide	peptide	JJ
cord-296347-fanlvxqs	151	41	exchange	exchange	NN
cord-296347-fanlvxqs	151	42	,	,	,
cord-296347-fanlvxqs	151	43	as	as	RB
cord-296347-fanlvxqs	151	44	well	well	RB
cord-296347-fanlvxqs	151	45	as	as	IN
cord-296347-fanlvxqs	151	46	the	the	DT
cord-296347-fanlvxqs	151	47	action	action	NN
cord-296347-fanlvxqs	151	48	of	of	IN
cord-296347-fanlvxqs	151	49	specific	specific	JJ
cord-296347-fanlvxqs	151	50	cysteine	cysteine	NN
cord-296347-fanlvxqs	151	51	proteases	protease	NNS
cord-296347-fanlvxqs	151	52	that	that	WDT
cord-296347-fanlvxqs	151	53	displace	displace	VBP
cord-296347-fanlvxqs	151	54	Ii	Ii	NNP
cord-296347-fanlvxqs	151	55	from	from	IN
cord-296347-fanlvxqs	151	56	the	the	DT
cord-296347-fanlvxqs	151	57	class	class	NN
cord-296347-fanlvxqs	151	58	II	II	NNP
cord-296347-fanlvxqs	151	59	MHC	MHC	NNP
cord-296347-fanlvxqs	151	60	-	-	HYPH
cord-296347-fanlvxqs	151	61	Ii	Ii	NNP
cord-296347-fanlvxqs	151	62	complex	complex	NN
cord-296347-fanlvxqs	151	63	,	,	,
cord-296347-fanlvxqs	151	64	and	and	CC
cord-296347-fanlvxqs	151	65	that	that	DT
cord-296347-fanlvxqs	151	66	of	of	IN
cord-296347-fanlvxqs	151	67	the	the	DT
cord-296347-fanlvxqs	151	68	class	class	NN
cord-296347-fanlvxqs	151	69	II	II	NNP
cord-296347-fanlvxqs	151	70	MHClike	MHClike	NNP
cord-296347-fanlvxqs	151	71	molecule	molecule	NN
cord-296347-fanlvxqs	151	72	HLA	HLA	NNP
cord-296347-fanlvxqs	151	73	-	-	HYPH
cord-296347-fanlvxqs	151	74	DM	DM	NNP
cord-296347-fanlvxqs	151	75	which	which	WDT
cord-296347-fanlvxqs	151	76	facilitates	facilitate	VBZ
cord-296347-fanlvxqs	151	77	peptide	peptide	JJ
cord-296347-fanlvxqs	151	78	loading	loading	NN
cord-296347-fanlvxqs	151	79	.	.	.
cord-296347-fanlvxqs	152	1	The	the	DT
cord-296347-fanlvxqs	152	2	many	many	JJ
cord-296347-fanlvxqs	152	3	hydrolase	hydrolase	NN
cord-296347-fanlvxqs	152	4	activities	activity	NNS
cord-296347-fanlvxqs	152	5	present	present	JJ
cord-296347-fanlvxqs	152	6	in	in	IN
cord-296347-fanlvxqs	152	7	the	the	DT
cord-296347-fanlvxqs	152	8	endolysosomal	endolysosomal	JJ
cord-296347-fanlvxqs	152	9	compartments	compartment	NNS
cord-296347-fanlvxqs	152	10	of	of	IN
cord-296347-fanlvxqs	152	11	APCs	apc	NNS
cord-296347-fanlvxqs	152	12	,	,	,
cord-296347-fanlvxqs	152	13	such	such	JJ
cord-296347-fanlvxqs	152	14	as	as	IN
cord-296347-fanlvxqs	152	15	the	the	DT
cord-296347-fanlvxqs	152	16	IFN	IFN	NNP
cord-296347-fanlvxqs	152	17	-	-	HYPH
cord-296347-fanlvxqs	152	18	g	g	NN
cord-296347-fanlvxqs	152	19	-	-	HYPH
cord-296347-fanlvxqs	152	20	inducible	inducible	JJ
cord-296347-fanlvxqs	152	21	lysosomal	lysosomal	JJ
cord-296347-fanlvxqs	152	22	thiol	thiol	NN
cord-296347-fanlvxqs	152	23	reductase	reductase	NN
cord-296347-fanlvxqs	152	24	(	(	-LRB-
cord-296347-fanlvxqs	152	25	GILT	GILT	NNP
cord-296347-fanlvxqs	152	26	)	)	-RRB-
cord-296347-fanlvxqs	152	27	,	,	,
cord-296347-fanlvxqs	152	28	numerous	numerous	JJ
cord-296347-fanlvxqs	152	29	cysteine	cysteine	NN
cord-296347-fanlvxqs	152	30	proteases	protease	NNS
cord-296347-fanlvxqs	152	31	of	of	IN
cord-296347-fanlvxqs	152	32	the	the	DT
cord-296347-fanlvxqs	152	33	cathepsin	cathepsin	NN
cord-296347-fanlvxqs	152	34	(	(	-LRB-
cord-296347-fanlvxqs	152	35	Cat	Cat	NNP
cord-296347-fanlvxqs	152	36	)	)	-RRB-
cord-296347-fanlvxqs	152	37	family	family	NN
cord-296347-fanlvxqs	152	38	,	,	,
cord-296347-fanlvxqs	152	39	like	like	IN
cord-296347-fanlvxqs	152	40	CatB	CatB	NNP
cord-296347-fanlvxqs	152	41	,	,	,
cord-296347-fanlvxqs	152	42	CatS	CatS	NNP
cord-296347-fanlvxqs	152	43	,	,	,
cord-296347-fanlvxqs	152	44	CatL	CatL	NNP
cord-296347-fanlvxqs	152	45	,	,	,
cord-296347-fanlvxqs	152	46	and	and	CC
cord-296347-fanlvxqs	152	47	asparaginyl	asparaginyl	NNP
cord-296347-fanlvxqs	152	48	endopeptidase	endopeptidase	NN
cord-296347-fanlvxqs	152	49	(	(	-LRB-
cord-296347-fanlvxqs	152	50	AEP	AEP	NNP
cord-296347-fanlvxqs	152	51	)	)	-RRB-
cord-296347-fanlvxqs	152	52	,	,	,
cord-296347-fanlvxqs	152	53	produce	produce	VB
cord-296347-fanlvxqs	152	54	the	the	DT
cord-296347-fanlvxqs	152	55	peptide	peptide	NN
cord-296347-fanlvxqs	152	56	ligands	ligand	NNS
cord-296347-fanlvxqs	152	57	that	that	WDT
cord-296347-fanlvxqs	152	58	are	be	VBP
cord-296347-fanlvxqs	152	59	loaded	load	VBN
cord-296347-fanlvxqs	152	60	onto	onto	IN
cord-296347-fanlvxqs	152	61	class	class	NN
cord-296347-fanlvxqs	152	62	II	II	NNP
cord-296347-fanlvxqs	152	63	MHC	MHC	NNP
cord-296347-fanlvxqs	152	64	products	product	NNS
cord-296347-fanlvxqs	152	65	.	.	.
cord-296347-fanlvxqs	153	1	Peptides	peptide	NNS
cord-296347-fanlvxqs	153	2	bound	bind	VBN
cord-296347-fanlvxqs	153	3	by	by	IN
cord-296347-fanlvxqs	153	4	class	class	NN
cord-296347-fanlvxqs	153	5	II	II	NNP
cord-296347-fanlvxqs	153	6	MHC	MHC	NNP
cord-296347-fanlvxqs	153	7	molecules	molecule	NNS
cord-296347-fanlvxqs	153	8	are	be	VBP
cord-296347-fanlvxqs	153	9	usually	usually	RB
cord-296347-fanlvxqs	153	10	13	13	CD
cord-296347-fanlvxqs	153	11	-	-	SYM
cord-296347-fanlvxqs	153	12	25	25	CD
cord-296347-fanlvxqs	153	13	residues	residue	NNS
cord-296347-fanlvxqs	153	14	long	long	RB
cord-296347-fanlvxqs	153	15	.	.	.
cord-296347-fanlvxqs	154	1	The	the	DT
cord-296347-fanlvxqs	154	2	end	end	NN
cord-296347-fanlvxqs	154	3	result	result	NN
cord-296347-fanlvxqs	154	4	is	be	VBZ
cord-296347-fanlvxqs	154	5	a	a	DT
cord-296347-fanlvxqs	154	6	mature	mature	JJ
cord-296347-fanlvxqs	154	7	class	class	NN
cord-296347-fanlvxqs	154	8	II	II	NNP
cord-296347-fanlvxqs	154	9	MHC	MHC	NNP
cord-296347-fanlvxqs	154	10	-	-	HYPH
cord-296347-fanlvxqs	154	11	peptide	peptide	NN
cord-296347-fanlvxqs	154	12	complex	complex	NN
cord-296347-fanlvxqs	154	13	at	at	IN
cord-296347-fanlvxqs	154	14	the	the	DT
cord-296347-fanlvxqs	154	15	cell	cell	NN
cord-296347-fanlvxqs	154	16	surface	surface	NN
cord-296347-fanlvxqs	154	17	,	,	,
cord-296347-fanlvxqs	154	18	consisting	consist	VBG
cord-296347-fanlvxqs	154	19	of	of	IN
cord-296347-fanlvxqs	154	20	a	a	DT
cord-296347-fanlvxqs	154	21	class	class	NN
cord-296347-fanlvxqs	154	22	II	II	NNP
cord-296347-fanlvxqs	154	23	MHC	MHC	NNP
cord-296347-fanlvxqs	154	24	ab	ab	NN
cord-296347-fanlvxqs	154	25	dimer	dimer	NN
cord-296347-fanlvxqs	154	26	loaded	load	VBN
cord-296347-fanlvxqs	154	27	with	with	IN
cord-296347-fanlvxqs	154	28	peptide	peptide	NN
cord-296347-fanlvxqs	154	29	,	,	,
cord-296347-fanlvxqs	154	30	which	which	WDT
cord-296347-fanlvxqs	154	31	interacts	interact	VBZ
cord-296347-fanlvxqs	154	32	with	with	IN
cord-296347-fanlvxqs	154	33	the	the	DT
cord-296347-fanlvxqs	154	34	TCR	TCR	NNP
cord-296347-fanlvxqs	154	35	on	on	IN
cord-296347-fanlvxqs	154	36	CD4	CD4	NNP
cord-296347-fanlvxqs	154	37	þ	þ	NNP
cord-296347-fanlvxqs	154	38	T	t	NN
cord-296347-fanlvxqs	154	39	cells	cell	NNS
cord-296347-fanlvxqs	154	40	.	.	.
cord-296347-fanlvxqs	155	1	The	the	DT
cord-296347-fanlvxqs	155	2	result	result	NN
cord-296347-fanlvxqs	155	3	of	of	IN
cord-296347-fanlvxqs	155	4	this	this	DT
cord-296347-fanlvxqs	155	5	interaction	interaction	NN
cord-296347-fanlvxqs	155	6	is	be	VBZ
cord-296347-fanlvxqs	155	7	dependent	dependent	JJ
cord-296347-fanlvxqs	155	8	on	on	IN
cord-296347-fanlvxqs	155	9	class	class	NN
cord-296347-fanlvxqs	155	10	II	II	NNP
cord-296347-fanlvxqs	155	11	MHC	MHC	NNP
cord-296347-fanlvxqs	155	12	-	-	HYPH
cord-296347-fanlvxqs	155	13	TCR	TCR	NNP
cord-296347-fanlvxqs	155	14	contacts	contact	NNS
cord-296347-fanlvxqs	155	15	and	and	CC
cord-296347-fanlvxqs	155	16	also	also	RB
cord-296347-fanlvxqs	155	17	on	on	IN
cord-296347-fanlvxqs	155	18	the	the	DT
cord-296347-fanlvxqs	155	19	context	context	NN
cord-296347-fanlvxqs	155	20	provided	provide	VBN
cord-296347-fanlvxqs	155	21	by	by	IN
cord-296347-fanlvxqs	155	22	lymphocyte	lymphocyte	NN
cord-296347-fanlvxqs	155	23	costimulatory	costimulatory	NN
cord-296347-fanlvxqs	155	24	molecules	molecule	NNS
cord-296347-fanlvxqs	155	25	at	at	IN
cord-296347-fanlvxqs	155	26	the	the	DT
cord-296347-fanlvxqs	155	27	immunological	immunological	JJ
cord-296347-fanlvxqs	155	28	synapse	synapse	NN
cord-296347-fanlvxqs	155	29	.	.	.
cord-296347-fanlvxqs	156	1	The	the	DT
cord-296347-fanlvxqs	156	2	CD4	CD4	NNP
cord-296347-fanlvxqs	156	3	þ	þ	NNP
cord-296347-fanlvxqs	156	4	T	T	NNP
cord-296347-fanlvxqs	156	5	cell	cell	NN
cord-296347-fanlvxqs	156	6	response	response	NN
cord-296347-fanlvxqs	156	7	may	may	MD
cord-296347-fanlvxqs	156	8	be	be	VB
cord-296347-fanlvxqs	156	9	cytolytic	cytolytic	JJ
cord-296347-fanlvxqs	156	10	,	,	,
cord-296347-fanlvxqs	156	11	but	but	CC
cord-296347-fanlvxqs	156	12	generally	generally	RB
cord-296347-fanlvxqs	156	13	these	these	DT
cord-296347-fanlvxqs	156	14	antigen	antigen	NN
cord-296347-fanlvxqs	156	15	-	-	HYPH
cord-296347-fanlvxqs	156	16	specific	specific	JJ
cord-296347-fanlvxqs	156	17	CD4	CD4	NNP
cord-296347-fanlvxqs	156	18	þ	þ	NNP
cord-296347-fanlvxqs	156	19	T	t	NN
cord-296347-fanlvxqs	156	20	lymphocytes	lymphocyte	NNS
cord-296347-fanlvxqs	156	21	function	function	VBP
cord-296347-fanlvxqs	156	22	as	as	IN
cord-296347-fanlvxqs	156	23	helper	helper	NN
cord-296347-fanlvxqs	156	24	cells	cell	NNS
cord-296347-fanlvxqs	156	25	,	,	,
cord-296347-fanlvxqs	156	26	releasing	release	VBG
cord-296347-fanlvxqs	156	27	cytokines	cytokine	NNS
cord-296347-fanlvxqs	156	28	to	to	TO
cord-296347-fanlvxqs	156	29	enhance	enhance	VB
cord-296347-fanlvxqs	156	30	the	the	DT
cord-296347-fanlvxqs	156	31	overall	overall	JJ
cord-296347-fanlvxqs	156	32	immune	immune	JJ
cord-296347-fanlvxqs	156	33	response	response	NN
cord-296347-fanlvxqs	156	34	by	by	IN
cord-296347-fanlvxqs	156	35	inducing	induce	VBG
cord-296347-fanlvxqs	156	36	macrophage	macrophage	NN
cord-296347-fanlvxqs	156	37	activation	activation	NN
cord-296347-fanlvxqs	156	38	,	,	,
cord-296347-fanlvxqs	156	39	T	T	NNP
cord-296347-fanlvxqs	156	40	and	and	CC
cord-296347-fanlvxqs	156	41	B	b	NN
cord-296347-fanlvxqs	156	42	cell	cell	NN
cord-296347-fanlvxqs	156	43	proliferation	proliferation	NN
cord-296347-fanlvxqs	156	44	,	,	,
cord-296347-fanlvxqs	156	45	and	and	CC
cord-296347-fanlvxqs	156	46	B	b	NN
cord-296347-fanlvxqs	156	47	cell	cell	NN
cord-296347-fanlvxqs	156	48	differentiation	differentiation	NN
cord-296347-fanlvxqs	156	49	to	to	TO
cord-296347-fanlvxqs	156	50	produce	produce	VB
cord-296347-fanlvxqs	156	51	antigen	antigen	NN
cord-296347-fanlvxqs	156	52	-	-	HYPH
cord-296347-fanlvxqs	156	53	specific	specific	JJ
cord-296347-fanlvxqs	156	54	antibodies	antibody	NNS
cord-296347-fanlvxqs	156	55	and	and	CC
cord-296347-fanlvxqs	156	56	different	different	JJ
cord-296347-fanlvxqs	156	57	immunoglobulin	immunoglobulin	NN
cord-296347-fanlvxqs	156	58	isotypes	isotypes	NN
cord-296347-fanlvxqs	156	59	with	with	IN
cord-296347-fanlvxqs	156	60	different	different	JJ
cord-296347-fanlvxqs	156	61	effector	effector	NN
cord-296347-fanlvxqs	156	62	functions	function	NNS
cord-296347-fanlvxqs	156	63	(	(	-LRB-
cord-296347-fanlvxqs	156	64	Bryant	Bryant	NNP
cord-296347-fanlvxqs	156	65	and	and	CC
cord-296347-fanlvxqs	156	66	Ploegh	Ploegh	NNP
cord-296347-fanlvxqs	156	67	,	,	,
cord-296347-fanlvxqs	156	68	2004	2004	CD
cord-296347-fanlvxqs	156	69	;	;	:
cord-296347-fanlvxqs	156	70	Chapman	Chapman	NNP
cord-296347-fanlvxqs	156	71	,	,	,
cord-296347-fanlvxqs	156	72	2006	2006	CD
cord-296347-fanlvxqs	156	73	;	;	:
cord-296347-fanlvxqs	156	74	Cresswell	Cresswell	NNP
cord-296347-fanlvxqs	156	75	,	,	,
cord-296347-fanlvxqs	156	76	1994	1994	CD
cord-296347-fanlvxqs	156	77	;	;	:
cord-296347-fanlvxqs	156	78	Honey	Honey	NNP
cord-296347-fanlvxqs	156	79	and	and	CC
cord-296347-fanlvxqs	156	80	Rudensky	Rudensky	NNP
cord-296347-fanlvxqs	156	81	,	,	,
cord-296347-fanlvxqs	156	82	2003	2003	CD
cord-296347-fanlvxqs	156	83	;	;	:
cord-296347-fanlvxqs	156	84	Hsing	Hsing	NNP
cord-296347-fanlvxqs	156	85	and	and	CC
cord-296347-fanlvxqs	156	86	Rudensky	Rudensky	NNP
cord-296347-fanlvxqs	156	87	,	,	,
cord-296347-fanlvxqs	156	88	2005	2005	CD
cord-296347-fanlvxqs	156	89	;	;	:
cord-296347-fanlvxqs	156	90	Stern	Stern	NNP
cord-296347-fanlvxqs	156	91	et	et	FW
cord-296347-fanlvxqs	156	92	al	al	NNP
cord-296347-fanlvxqs	156	93	.	.	NNP
cord-296347-fanlvxqs	156	94	,	,	,
cord-296347-fanlvxqs	156	95	2006	2006	CD
cord-296347-fanlvxqs	156	96	;	;	:
cord-296347-fanlvxqs	156	97	Villadangos	Villadangos	NNP
cord-296347-fanlvxqs	156	98	et	et	NNP
cord-296347-fanlvxqs	156	99	al	al	NNP
cord-296347-fanlvxqs	156	100	.	.	NNP
cord-296347-fanlvxqs	156	101	,	,	,
cord-296347-fanlvxqs	156	102	1999	1999	CD
cord-296347-fanlvxqs	156	103	)	)	-RRB-
cord-296347-fanlvxqs	156	104	.	.	.
cord-296347-fanlvxqs	157	1	All	all	DT
cord-296347-fanlvxqs	157	2	cellular	cellular	JJ
cord-296347-fanlvxqs	157	3	proteins	protein	NNS
cord-296347-fanlvxqs	157	4	,	,	,
cord-296347-fanlvxqs	157	5	regardless	regardless	RB
cord-296347-fanlvxqs	157	6	of	of	IN
cord-296347-fanlvxqs	157	7	their	-PRON-	PRP$
cord-296347-fanlvxqs	157	8	half	half	JJ
cord-296347-fanlvxqs	157	9	-	-	HYPH
cord-296347-fanlvxqs	157	10	life	life	NN
cord-296347-fanlvxqs	157	11	,	,	,
cord-296347-fanlvxqs	157	12	are	be	VBP
cord-296347-fanlvxqs	157	13	subject	subject	JJ
cord-296347-fanlvxqs	157	14	to	to	IN
cord-296347-fanlvxqs	157	15	turnover	turnover	NN
cord-296347-fanlvxqs	157	16	.	.	.
cord-296347-fanlvxqs	158	1	The	the	DT
cord-296347-fanlvxqs	158	2	main	main	JJ
cord-296347-fanlvxqs	158	3	pathway	pathway	NN
cord-296347-fanlvxqs	158	4	for	for	IN
cord-296347-fanlvxqs	158	5	degradation	degradation	NN
cord-296347-fanlvxqs	158	6	of	of	IN
cord-296347-fanlvxqs	158	7	short	short	RB
cord-296347-fanlvxqs	158	8	-	-	HYPH
cord-296347-fanlvxqs	158	9	lived	live	VBN
cord-296347-fanlvxqs	158	10	proteins	protein	NNS
cord-296347-fanlvxqs	158	11	in	in	IN
cord-296347-fanlvxqs	158	12	the	the	DT
cord-296347-fanlvxqs	158	13	cytoplasm	cytoplasm	NN
cord-296347-fanlvxqs	158	14	of	of	IN
cord-296347-fanlvxqs	158	15	eukaryotic	eukaryotic	JJ
cord-296347-fanlvxqs	158	16	cells	cell	NNS
cord-296347-fanlvxqs	158	17	is	be	VBZ
cord-296347-fanlvxqs	158	18	the	the	DT
cord-296347-fanlvxqs	158	19	Ub	Ub	NNP
cord-296347-fanlvxqs	158	20	-	-	HYPH
cord-296347-fanlvxqs	158	21	proteasome	proteasome	NN
cord-296347-fanlvxqs	158	22	system	system	NN
cord-296347-fanlvxqs	158	23	(	(	-LRB-
cord-296347-fanlvxqs	158	24	Hershko	Hershko	NNP
cord-296347-fanlvxqs	158	25	and	and	CC
cord-296347-fanlvxqs	158	26	Ciechanover	Ciechanover	NNP
cord-296347-fanlvxqs	158	27	,	,	,
cord-296347-fanlvxqs	158	28	1992	1992	CD
cord-296347-fanlvxqs	158	29	)	)	-RRB-
cord-296347-fanlvxqs	158	30	.	.	.
cord-296347-fanlvxqs	159	1	Since	since	IN
cord-296347-fanlvxqs	159	2	the	the	DT
cord-296347-fanlvxqs	159	3	discovery	discovery	NN
cord-296347-fanlvxqs	159	4	of	of	IN
cord-296347-fanlvxqs	159	5	Ub	Ub	NNP
cord-296347-fanlvxqs	159	6	and	and	CC
cord-296347-fanlvxqs	159	7	Ub	ub	JJ
cord-296347-fanlvxqs	159	8	-	-	HYPH
cord-296347-fanlvxqs	159	9	dependent	dependent	JJ
cord-296347-fanlvxqs	159	10	proteolysis	proteolysis	NN
cord-296347-fanlvxqs	159	11	in	in	IN
cord-296347-fanlvxqs	159	12	the	the	DT
cord-296347-fanlvxqs	159	13	late	late	JJ
cord-296347-fanlvxqs	159	14	1970s	1970	NNS
cord-296347-fanlvxqs	159	15	,	,	,
cord-296347-fanlvxqs	159	16	it	-PRON-	PRP
cord-296347-fanlvxqs	159	17	has	have	VBZ
cord-296347-fanlvxqs	159	18	become	become	VBN
cord-296347-fanlvxqs	159	19	increasingly	increasingly	RB
cord-296347-fanlvxqs	159	20	clear	clear	JJ
cord-296347-fanlvxqs	159	21	that	that	IN
cord-296347-fanlvxqs	159	22	the	the	DT
cord-296347-fanlvxqs	159	23	Ub	Ub	NNP
cord-296347-fanlvxqs	159	24	-	-	HYPH
cord-296347-fanlvxqs	159	25	proteasome	proteasome	NN
cord-296347-fanlvxqs	159	26	system	system	NN
cord-296347-fanlvxqs	159	27	is	be	VBZ
cord-296347-fanlvxqs	159	28	pivotal	pivotal	JJ
cord-296347-fanlvxqs	159	29	to	to	IN
cord-296347-fanlvxqs	159	30	numerous	numerous	JJ
cord-296347-fanlvxqs	159	31	cellular	cellular	JJ
cord-296347-fanlvxqs	159	32	processes	process	NNS
cord-296347-fanlvxqs	159	33	:	:	:
cord-296347-fanlvxqs	159	34	cell	cell	NN
cord-296347-fanlvxqs	159	35	cycle	cycle	NN
cord-296347-fanlvxqs	159	36	control	control	NN
cord-296347-fanlvxqs	159	37	,	,	,
cord-296347-fanlvxqs	159	38	transcriptional	transcriptional	JJ
cord-296347-fanlvxqs	159	39	regulation	regulation	NN
cord-296347-fanlvxqs	159	40	,	,	,
cord-296347-fanlvxqs	159	41	signal	signal	NN
cord-296347-fanlvxqs	159	42	transduction	transduction	NN
cord-296347-fanlvxqs	159	43	,	,	,
cord-296347-fanlvxqs	159	44	antigen	antigen	NN
cord-296347-fanlvxqs	159	45	presentation	presentation	NN
cord-296347-fanlvxqs	159	46	and	and	CC
cord-296347-fanlvxqs	159	47	induction	induction	NN
cord-296347-fanlvxqs	159	48	of	of	IN
cord-296347-fanlvxqs	159	49	the	the	DT
cord-296347-fanlvxqs	159	50	inflammatory	inflammatory	JJ
cord-296347-fanlvxqs	159	51	response	response	NN
cord-296347-fanlvxqs	159	52	,	,	,
cord-296347-fanlvxqs	159	53	degradation	degradation	NN
cord-296347-fanlvxqs	159	54	from	from	IN
cord-296347-fanlvxqs	159	55	the	the	DT
cord-296347-fanlvxqs	159	56	ER	er	NN
cord-296347-fanlvxqs	159	57	,	,	,
cord-296347-fanlvxqs	159	58	membrane	membrane	NN
cord-296347-fanlvxqs	159	59	trafficking	trafficking	NN
cord-296347-fanlvxqs	159	60	,	,	,
cord-296347-fanlvxqs	159	61	receptor	receptor	NN
cord-296347-fanlvxqs	159	62	endocytosis	endocytosis	NN
cord-296347-fanlvxqs	159	63	and	and	CC
cord-296347-fanlvxqs	159	64	downregulation	downregulation	NN
cord-296347-fanlvxqs	159	65	,	,	,
cord-296347-fanlvxqs	159	66	apoptosis	apoptosis	NN
cord-296347-fanlvxqs	159	67	,	,	,
cord-296347-fanlvxqs	159	68	and	and	CC
cord-296347-fanlvxqs	159	69	development	development	NN
cord-296347-fanlvxqs	159	70	(	(	-LRB-
cord-296347-fanlvxqs	159	71	Hershko	Hershko	NNP
cord-296347-fanlvxqs	159	72	and	and	CC
cord-296347-fanlvxqs	159	73	Ciechanover	Ciechanover	NNP
cord-296347-fanlvxqs	159	74	,	,	,
cord-296347-fanlvxqs	159	75	1992	1992	CD
cord-296347-fanlvxqs	159	76	;	;	:
cord-296347-fanlvxqs	159	77	Pickart	Pickart	NNP
cord-296347-fanlvxqs	159	78	,	,	,
cord-296347-fanlvxqs	159	79	2001	2001	CD
cord-296347-fanlvxqs	159	80	)	)	-RRB-
cord-296347-fanlvxqs	159	81	.	.	.
cord-296347-fanlvxqs	160	1	Ubiquitin	Ubiquitin	NNP
cord-296347-fanlvxqs	160	2	is	be	VBZ
cord-296347-fanlvxqs	160	3	a	a	DT
cord-296347-fanlvxqs	160	4	small	small	JJ
cord-296347-fanlvxqs	160	5	76-amino	76-amino	CD
cord-296347-fanlvxqs	160	6	acid	acid	NN
cord-296347-fanlvxqs	160	7	protein	protein	NN
cord-296347-fanlvxqs	160	8	,	,	,
cord-296347-fanlvxqs	160	9	synthesized	synthesize	VBN
cord-296347-fanlvxqs	160	10	as	as	IN
cord-296347-fanlvxqs	160	11	a	a	DT
cord-296347-fanlvxqs	160	12	precursor	precursor	NN
cord-296347-fanlvxqs	160	13	that	that	WDT
cord-296347-fanlvxqs	160	14	is	be	VBZ
cord-296347-fanlvxqs	160	15	processed	process	VBN
cord-296347-fanlvxqs	160	16	by	by	IN
cord-296347-fanlvxqs	160	17	deubiquitinating	deubiquitinate	VBG
cord-296347-fanlvxqs	160	18	enzymes	enzyme	NNS
cord-296347-fanlvxqs	160	19	(	(	-LRB-
cord-296347-fanlvxqs	160	20	DUBs	dub	NNS
cord-296347-fanlvxqs	160	21	)	)	-RRB-
cord-296347-fanlvxqs	160	22	to	to	TO
cord-296347-fanlvxqs	160	23	expose	expose	VB
cord-296347-fanlvxqs	160	24	the	the	DT
cord-296347-fanlvxqs	160	25	glycine	glycine	NN
cord-296347-fanlvxqs	160	26	-	-	HYPH
cord-296347-fanlvxqs	160	27	glycine	glycine	NN
cord-296347-fanlvxqs	160	28	sequence	sequence	NN
cord-296347-fanlvxqs	160	29	at	at	IN
cord-296347-fanlvxqs	160	30	the	the	DT
cord-296347-fanlvxqs	160	31	Ub	Ub	NNP
cord-296347-fanlvxqs	160	32	C	C	NNP
cord-296347-fanlvxqs	160	33	-	-	HYPH
cord-296347-fanlvxqs	160	34	terminus	terminus	NN
cord-296347-fanlvxqs	160	35	,	,	,
cord-296347-fanlvxqs	160	36	its	-PRON-	PRP$
cord-296347-fanlvxqs	160	37	site	site	NN
cord-296347-fanlvxqs	160	38	of	of	IN
cord-296347-fanlvxqs	160	39	attachment	attachment	NN
cord-296347-fanlvxqs	160	40	to	to	TO
cord-296347-fanlvxqs	160	41	target	target	VB
cord-296347-fanlvxqs	160	42	molecules	molecule	NNS
cord-296347-fanlvxqs	160	43	.	.	.
cord-296347-fanlvxqs	161	1	ATP	ATP	NNP
cord-296347-fanlvxqs	161	2	-	-	HYPH
cord-296347-fanlvxqs	161	3	dependent	dependent	JJ
cord-296347-fanlvxqs	161	4	Ub	Ub	NNP
cord-296347-fanlvxqs	161	5	activation	activation	NN
cord-296347-fanlvxqs	161	6	is	be	VBZ
cord-296347-fanlvxqs	161	7	catalyzed	catalyze	VBN
cord-296347-fanlvxqs	161	8	by	by	IN
cord-296347-fanlvxqs	161	9	the	the	DT
cord-296347-fanlvxqs	161	10	E1	e1	NN
cord-296347-fanlvxqs	161	11	(	(	-LRB-
cord-296347-fanlvxqs	161	12	Ub	Ub	NNP
cord-296347-fanlvxqs	161	13	-	-	HYPH
cord-296347-fanlvxqs	161	14	activating	activate	VBG
cord-296347-fanlvxqs	161	15	)	)	-RRB-
cord-296347-fanlvxqs	161	16	enzyme	enzyme	NN
cord-296347-fanlvxqs	161	17	,	,	,
cord-296347-fanlvxqs	161	18	which	which	WDT
cord-296347-fanlvxqs	161	19	adenylates	adenylate	VBZ
cord-296347-fanlvxqs	161	20	the	the	DT
cord-296347-fanlvxqs	161	21	Ub	Ub	NNP
cord-296347-fanlvxqs	161	22	C	C	NNP
cord-296347-fanlvxqs	161	23	-	-	HYPH
cord-296347-fanlvxqs	161	24	terminus	terminus	NNP
cord-296347-fanlvxqs	161	25	,	,	,
cord-296347-fanlvxqs	161	26	allowing	allow	VBG
cord-296347-fanlvxqs	161	27	the	the	DT
cord-296347-fanlvxqs	161	28	subsequent	subsequent	JJ
cord-296347-fanlvxqs	161	29	formation	formation	NN
cord-296347-fanlvxqs	161	30	of	of	IN
cord-296347-fanlvxqs	161	31	a	a	DT
cord-296347-fanlvxqs	161	32	high	high	JJ
cord-296347-fanlvxqs	161	33	-	-	HYPH
cord-296347-fanlvxqs	161	34	energy	energy	NN
cord-296347-fanlvxqs	161	35	thioester	thioester	NN
cord-296347-fanlvxqs	161	36	bond	bond	NN
cord-296347-fanlvxqs	161	37	between	between	IN
cord-296347-fanlvxqs	161	38	the	the	DT
cord-296347-fanlvxqs	161	39	glycine	glycine	NN
cord-296347-fanlvxqs	161	40	residue	residue	NN
cord-296347-fanlvxqs	161	41	of	of	IN
cord-296347-fanlvxqs	161	42	Ub	Ub	NNP
cord-296347-fanlvxqs	161	43	and	and	CC
cord-296347-fanlvxqs	161	44	the	the	DT
cord-296347-fanlvxqs	161	45	cysteine	cysteine	NN
cord-296347-fanlvxqs	161	46	residue	residue	NN
cord-296347-fanlvxqs	161	47	on	on	IN
cord-296347-fanlvxqs	161	48	the	the	DT
cord-296347-fanlvxqs	161	49	E1	e1	NN
cord-296347-fanlvxqs	161	50	active	active	JJ
cord-296347-fanlvxqs	161	51	site	site	NN
cord-296347-fanlvxqs	161	52	.	.	.
cord-296347-fanlvxqs	162	1	Ub	Ub	NNP
cord-296347-fanlvxqs	162	2	is	be	VBZ
cord-296347-fanlvxqs	162	3	then	then	RB
cord-296347-fanlvxqs	162	4	transferred	transfer	VBN
cord-296347-fanlvxqs	162	5	from	from	IN
cord-296347-fanlvxqs	162	6	the	the	DT
cord-296347-fanlvxqs	162	7	E1	E1	NNP
cord-296347-fanlvxqs	162	8	cysteinyl	cysteinyl	NNP
cord-296347-fanlvxqs	162	9	side	side	NN
cord-296347-fanlvxqs	162	10	chain	chain	NN
cord-296347-fanlvxqs	162	11	to	to	IN
cord-296347-fanlvxqs	162	12	a	a	DT
cord-296347-fanlvxqs	162	13	cysteinyl	cysteinyl	JJ
cord-296347-fanlvxqs	162	14	group	group	NN
cord-296347-fanlvxqs	162	15	on	on	IN
cord-296347-fanlvxqs	162	16	one	one	CD
cord-296347-fanlvxqs	162	17	of	of	IN
cord-296347-fanlvxqs	162	18	several	several	JJ
cord-296347-fanlvxqs	162	19	E2	e2	NN
cord-296347-fanlvxqs	162	20	(	(	-LRB-
cord-296347-fanlvxqs	162	21	Ub	Ub	NNP
cord-296347-fanlvxqs	162	22	-	-	HYPH
cord-296347-fanlvxqs	162	23	conjugating	conjugating	NN
cord-296347-fanlvxqs	162	24	)	)	-RRB-
cord-296347-fanlvxqs	162	25	enzymes	enzyme	NNS
cord-296347-fanlvxqs	162	26	.	.	.
cord-296347-fanlvxqs	163	1	Finally	finally	RB
cord-296347-fanlvxqs	163	2	,	,	,
cord-296347-fanlvxqs	163	3	one	one	CD
cord-296347-fanlvxqs	163	4	of	of	IN
cord-296347-fanlvxqs	163	5	hundreds	hundred	NNS
cord-296347-fanlvxqs	163	6	of	of	IN
cord-296347-fanlvxqs	163	7	E3	E3	NNP
cord-296347-fanlvxqs	163	8	(	(	-LRB-
cord-296347-fanlvxqs	163	9	Ub	Ub	NNP
cord-296347-fanlvxqs	163	10	-	-	HYPH
cord-296347-fanlvxqs	163	11	ligase	ligase	NN
cord-296347-fanlvxqs	163	12	)	)	-RRB-
cord-296347-fanlvxqs	163	13	enzymes	enzyme	NNS
cord-296347-fanlvxqs	163	14	,	,	,
cord-296347-fanlvxqs	163	15	binds	bind	VBZ
cord-296347-fanlvxqs	163	16	the	the	DT
cord-296347-fanlvxqs	163	17	Ub	Ub	NNP
cord-296347-fanlvxqs	163	18	-	-	HYPH
cord-296347-fanlvxqs	163	19	E2	E2	NNP
cord-296347-fanlvxqs	163	20	complex	complex	NN
cord-296347-fanlvxqs	163	21	and	and	CC
cord-296347-fanlvxqs	163	22	the	the	DT
cord-296347-fanlvxqs	163	23	substrate	substrate	NN
cord-296347-fanlvxqs	163	24	,	,	,
cord-296347-fanlvxqs	163	25	thus	thus	RB
cord-296347-fanlvxqs	163	26	facilitating	facilitate	VBG
cord-296347-fanlvxqs	163	27	the	the	DT
cord-296347-fanlvxqs	163	28	transfer	transfer	NN
cord-296347-fanlvxqs	163	29	of	of	IN
cord-296347-fanlvxqs	163	30	Ub	Ub	NNP
cord-296347-fanlvxqs	163	31	to	to	IN
cord-296347-fanlvxqs	163	32	a	a	DT
cord-296347-fanlvxqs	163	33	lysine	lysine	NN
cord-296347-fanlvxqs	163	34	residue	residue	NN
cord-296347-fanlvxqs	163	35	in	in	IN
cord-296347-fanlvxqs	163	36	the	the	DT
cord-296347-fanlvxqs	163	37	substrate	substrate	NN
cord-296347-fanlvxqs	163	38	via	via	IN
cord-296347-fanlvxqs	163	39	an	an	DT
cord-296347-fanlvxqs	163	40	amide	amide	NN
cord-296347-fanlvxqs	163	41	(	(	-LRB-
cord-296347-fanlvxqs	163	42	isopeptide	isopeptide	NNP
cord-296347-fanlvxqs	163	43	)	)	-RRB-
cord-296347-fanlvxqs	163	44	bond	bond	NN
cord-296347-fanlvxqs	163	45	(	(	-LRB-
cord-296347-fanlvxqs	163	46	Hershko	Hershko	NNP
cord-296347-fanlvxqs	163	47	and	and	CC
cord-296347-fanlvxqs	163	48	Ciechanover	Ciechanover	NNP
cord-296347-fanlvxqs	163	49	,	,	,
cord-296347-fanlvxqs	163	50	1992	1992	CD
cord-296347-fanlvxqs	163	51	)	)	-RRB-
cord-296347-fanlvxqs	163	52	.	.	.
cord-296347-fanlvxqs	164	1	The	the	DT
cord-296347-fanlvxqs	164	2	functions	function	NNS
cord-296347-fanlvxqs	164	3	of	of	IN
cord-296347-fanlvxqs	164	4	E3	e3	NN
cord-296347-fanlvxqs	164	5	ligases	ligase	NNS
cord-296347-fanlvxqs	164	6	,	,	,
cord-296347-fanlvxqs	164	7	in	in	IN
cord-296347-fanlvxqs	164	8	particular	particular	JJ
cord-296347-fanlvxqs	164	9	,	,	,
cord-296347-fanlvxqs	164	10	are	be	VBP
cord-296347-fanlvxqs	164	11	tightly	tightly	RB
cord-296347-fanlvxqs	164	12	regulated	regulate	VBN
cord-296347-fanlvxqs	164	13	by	by	IN
cord-296347-fanlvxqs	164	14	signalinduced	signalinduced	JJ
cord-296347-fanlvxqs	164	15	mechanisms	mechanism	NNS
cord-296347-fanlvxqs	164	16	,	,	,
cord-296347-fanlvxqs	164	17	such	such	JJ
cord-296347-fanlvxqs	164	18	as	as	IN
cord-296347-fanlvxqs	164	19	localization	localization	NN
cord-296347-fanlvxqs	164	20	,	,	,
cord-296347-fanlvxqs	164	21	oligomerization	oligomerization	NN
cord-296347-fanlvxqs	164	22	,	,	,
cord-296347-fanlvxqs	164	23	degradation	degradation	NN
cord-296347-fanlvxqs	164	24	,	,	,
cord-296347-fanlvxqs	164	25	and	and	CC
cord-296347-fanlvxqs	164	26	posttranslational	posttranslational	JJ
cord-296347-fanlvxqs	164	27	modifications	modification	NNS
cord-296347-fanlvxqs	164	28	,	,	,
cord-296347-fanlvxqs	164	29	which	which	WDT
cord-296347-fanlvxqs	164	30	makes	make	VBZ
cord-296347-fanlvxqs	164	31	E3s	e3	VBN
cord-296347-fanlvxqs	164	32	the	the	DT
cord-296347-fanlvxqs	164	33	master	master	NN
cord-296347-fanlvxqs	164	34	orchestrators	orchestrator	NNS
cord-296347-fanlvxqs	164	35	of	of	IN
cord-296347-fanlvxqs	164	36	specificity	specificity	NN
cord-296347-fanlvxqs	164	37	in	in	IN
cord-296347-fanlvxqs	164	38	the	the	DT
cord-296347-fanlvxqs	164	39	Ub	ub	JJ
cord-296347-fanlvxqs	164	40	conjugation	conjugation	NN
cord-296347-fanlvxqs	164	41	cascade	cascade	NN
cord-296347-fanlvxqs	164	42	.	.	.
cord-296347-fanlvxqs	165	1	This	this	DT
cord-296347-fanlvxqs	165	2	multistep	multistep	JJ
cord-296347-fanlvxqs	165	3	mechanism	mechanism	NN
cord-296347-fanlvxqs	165	4	,	,	,
cord-296347-fanlvxqs	165	5	much	much	JJ
cord-296347-fanlvxqs	165	6	like	like	IN
cord-296347-fanlvxqs	165	7	phosphorylation	phosphorylation	NN
cord-296347-fanlvxqs	165	8	,	,	,
cord-296347-fanlvxqs	165	9	endows	endow	VBZ
cord-296347-fanlvxqs	165	10	protein	protein	NN
cord-296347-fanlvxqs	165	11	ubiquitination	ubiquitination	NN
cord-296347-fanlvxqs	165	12	with	with	IN
cord-296347-fanlvxqs	165	13	a	a	DT
cord-296347-fanlvxqs	165	14	high	high	JJ
cord-296347-fanlvxqs	165	15	degree	degree	NN
cord-296347-fanlvxqs	165	16	of	of	IN
cord-296347-fanlvxqs	165	17	specificity	specificity	NN
cord-296347-fanlvxqs	165	18	and	and	CC
cord-296347-fanlvxqs	165	19	flexibility	flexibility	NN
cord-296347-fanlvxqs	165	20	,	,	,
cord-296347-fanlvxqs	165	21	which	which	WDT
cord-296347-fanlvxqs	165	22	is	be	VBZ
cord-296347-fanlvxqs	165	23	paramount	paramount	NN
cord-296347-fanlvxqs	165	24	to	to	IN
cord-296347-fanlvxqs	165	25	its	-PRON-	PRP$
cord-296347-fanlvxqs	165	26	important	important	JJ
cord-296347-fanlvxqs	165	27	biological	biological	JJ
cord-296347-fanlvxqs	165	28	functions	function	NNS
cord-296347-fanlvxqs	165	29	(	(	-LRB-
cord-296347-fanlvxqs	165	30	Haglund	Haglund	NNP
cord-296347-fanlvxqs	165	31	and	and	CC
cord-296347-fanlvxqs	165	32	Dikic	Dikic	NNP
cord-296347-fanlvxqs	165	33	,	,	,
cord-296347-fanlvxqs	165	34	2005	2005	CD
cord-296347-fanlvxqs	165	35	;	;	:
cord-296347-fanlvxqs	165	36	Hershko	Hershko	NNP
cord-296347-fanlvxqs	165	37	and	and	CC
cord-296347-fanlvxqs	165	38	Ciechanover	Ciechanover	NNP
cord-296347-fanlvxqs	165	39	,	,	,
cord-296347-fanlvxqs	165	40	1998	1998	CD
cord-296347-fanlvxqs	165	41	;	;	:
cord-296347-fanlvxqs	165	42	Pickart	Pickart	NNP
cord-296347-fanlvxqs	165	43	,	,	,
cord-296347-fanlvxqs	165	44	2001	2001	CD
cord-296347-fanlvxqs	165	45	Pickart	Pickart	NNP
cord-296347-fanlvxqs	165	46	,	,	,
cord-296347-fanlvxqs	165	47	,	,	,
cord-296347-fanlvxqs	165	48	2004	2004	CD
cord-296347-fanlvxqs	165	49	Varshavsky	Varshavsky	NNP
cord-296347-fanlvxqs	165	50	,	,	,
cord-296347-fanlvxqs	165	51	2005	2005	CD
cord-296347-fanlvxqs	165	52	)	)	-RRB-
cord-296347-fanlvxqs	166	1	(	(	-LRB-
cord-296347-fanlvxqs	166	2	Fig	Fig	NNP
cord-296347-fanlvxqs	166	3	.	.	.
cord-296347-fanlvxqs	166	4	2A	2a	CD
cord-296347-fanlvxqs	166	5	)	)	-RRB-
cord-296347-fanlvxqs	166	6	.	.	.
cord-296347-fanlvxqs	167	1	Overview	overview	NN
cord-296347-fanlvxqs	167	2	of	of	IN
cord-296347-fanlvxqs	167	3	the	the	DT
cord-296347-fanlvxqs	167	4	Ub	Ub	NNP
cord-296347-fanlvxqs	167	5	-	-	HYPH
cord-296347-fanlvxqs	167	6	proteasome	proteasome	NN
cord-296347-fanlvxqs	167	7	system	system	NN
cord-296347-fanlvxqs	167	8	.	.	.
cord-296347-fanlvxqs	168	1	(	(	-LRB-
cord-296347-fanlvxqs	168	2	A	a	NN
cord-296347-fanlvxqs	168	3	)	)	-RRB-
cord-296347-fanlvxqs	168	4	Ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	168	5	-	-	HYPH
cord-296347-fanlvxqs	168	6	conjugation	conjugation	NN
cord-296347-fanlvxqs	168	7	cascade	cascade	NN
cord-296347-fanlvxqs	168	8	and	and	CC
cord-296347-fanlvxqs	168	9	how	how	WRB
cord-296347-fanlvxqs	168	10	Ub	ub	JJ
cord-296347-fanlvxqs	168	11	chain	chain	NN
cord-296347-fanlvxqs	168	12	linkage	linkage	NN
cord-296347-fanlvxqs	168	13	type	type	NN
cord-296347-fanlvxqs	168	14	and	and	CC
cord-296347-fanlvxqs	168	15	length	length	NN
cord-296347-fanlvxqs	168	16	influence	influence	NN
cord-296347-fanlvxqs	168	17	substrate	substrate	NN
cord-296347-fanlvxqs	168	18	fate	fate	NN
cord-296347-fanlvxqs	168	19	.	.	.
cord-296347-fanlvxqs	169	1	E1	E1	NNP
cord-296347-fanlvxqs	169	2	,	,	,
cord-296347-fanlvxqs	169	3	Ub	Ub	NNP
cord-296347-fanlvxqs	169	4	-	-	HYPH
cord-296347-fanlvxqs	169	5	activating	activate	VBG
cord-296347-fanlvxqs	169	6	enzyme	enzyme	NN
cord-296347-fanlvxqs	169	7	;	;	:
cord-296347-fanlvxqs	169	8	E2	E2	NNP
cord-296347-fanlvxqs	169	9	,	,	,
cord-296347-fanlvxqs	169	10	Ubconjugating	Ubconjugating	NNP
cord-296347-fanlvxqs	169	11	enzyme	enzyme	NN
cord-296347-fanlvxqs	169	12	;	;	:
cord-296347-fanlvxqs	169	13	E3	E3	NNP
cord-296347-fanlvxqs	169	14	,	,	,
cord-296347-fanlvxqs	169	15	Ub	Ub	NNP
cord-296347-fanlvxqs	169	16	-	-	HYPH
cord-296347-fanlvxqs	169	17	ligase	ligase	NN
cord-296347-fanlvxqs	169	18	enzyme	enzyme	NN
cord-296347-fanlvxqs	169	19	;	;	:
cord-296347-fanlvxqs	169	20	and	and	CC
cord-296347-fanlvxqs	169	21	DUB	DUB	NNP
cord-296347-fanlvxqs	169	22	,	,	,
cord-296347-fanlvxqs	169	23	deubiquitinating	deubiquitinating	NN
cord-296347-fanlvxqs	169	24	enzyme	enzyme	NN
cord-296347-fanlvxqs	169	25	.	.	.
cord-296347-fanlvxqs	170	1	(	(	-LRB-
cord-296347-fanlvxqs	170	2	B	b	NN
cord-296347-fanlvxqs	170	3	)	)	-RRB-
cord-296347-fanlvxqs	170	4	Diversity	diversity	NN
cord-296347-fanlvxqs	170	5	in	in	IN
cord-296347-fanlvxqs	170	6	E3	E3	NNP
cord-296347-fanlvxqs	170	7	ligases	ligase	NNS
cord-296347-fanlvxqs	170	8	.	.	.
cord-296347-fanlvxqs	171	1	E3s	e3s	PRP
cord-296347-fanlvxqs	171	2	play	play	VB
cord-296347-fanlvxqs	171	3	crucial	crucial	JJ
cord-296347-fanlvxqs	171	4	roles	role	NNS
cord-296347-fanlvxqs	171	5	in	in	IN
cord-296347-fanlvxqs	171	6	substrate	substrate	NN
cord-296347-fanlvxqs	171	7	selection	selection	NN
cord-296347-fanlvxqs	171	8	and	and	CC
cord-296347-fanlvxqs	171	9	can	can	MD
cord-296347-fanlvxqs	171	10	be	be	VB
cord-296347-fanlvxqs	171	11	regulated	regulate	VBN
cord-296347-fanlvxqs	171	12	by	by	IN
cord-296347-fanlvxqs	171	13	localization	localization	NN
cord-296347-fanlvxqs	171	14	,	,	,
cord-296347-fanlvxqs	171	15	oligomerization	oligomerization	NN
cord-296347-fanlvxqs	171	16	,	,	,
cord-296347-fanlvxqs	171	17	associated	associate	VBN
cord-296347-fanlvxqs	171	18	E2s	E2s	NNP
cord-296347-fanlvxqs	171	19	,	,	,
cord-296347-fanlvxqs	171	20	posttranslational	posttranslational	JJ
cord-296347-fanlvxqs	171	21	modifications	modification	NNS
cord-296347-fanlvxqs	171	22	,	,	,
cord-296347-fanlvxqs	171	23	and	and	CC
cord-296347-fanlvxqs	171	24	degradation	degradation	NN
cord-296347-fanlvxqs	171	25	.	.	.
cord-296347-fanlvxqs	172	1	Hrd1p	Hrd1p	NNP
cord-296347-fanlvxqs	172	2	and	and	CC
cord-296347-fanlvxqs	172	3	Doa10p	Doa10p	NNP
cord-296347-fanlvxqs	172	4	are	be	VBP
cord-296347-fanlvxqs	172	5	yeast	yeast	NN
cord-296347-fanlvxqs	172	6	E3	e3	NN
cord-296347-fanlvxqs	172	7	ligases	ligase	NNS
cord-296347-fanlvxqs	172	8	that	that	WDT
cord-296347-fanlvxqs	172	9	are	be	VBP
cord-296347-fanlvxqs	172	10	multispanning	multispanne	VBG
cord-296347-fanlvxqs	172	11	membrane	membrane	NN
cord-296347-fanlvxqs	172	12	proteins	protein	NNS
cord-296347-fanlvxqs	172	13	of	of	IN
cord-296347-fanlvxqs	172	14	the	the	DT
cord-296347-fanlvxqs	172	15	ER	ER	NNP
cord-296347-fanlvxqs	172	16	and	and	CC
cord-296347-fanlvxqs	172	17	,	,	,
cord-296347-fanlvxqs	172	18	in	in	IN
cord-296347-fanlvxqs	172	19	the	the	DT
cord-296347-fanlvxqs	172	20	case	case	NN
cord-296347-fanlvxqs	172	21	of	of	IN
cord-296347-fanlvxqs	172	22	Doa10p	Doa10p	NNP
cord-296347-fanlvxqs	172	23	,	,	,
cord-296347-fanlvxqs	172	24	nuclear	nuclear	JJ
cord-296347-fanlvxqs	172	25	envelope	envelope	NN
cord-296347-fanlvxqs	172	26	.	.	.
cord-296347-fanlvxqs	173	1	The	the	DT
cord-296347-fanlvxqs	173	2	mammalian	mammalian	JJ
cord-296347-fanlvxqs	173	3	SCF	scf	NN
cord-296347-fanlvxqs	173	4	family	family	NN
cord-296347-fanlvxqs	173	5	of	of	IN
cord-296347-fanlvxqs	173	6	E3	E3	NNP
cord-296347-fanlvxqs	173	7	ligases	ligase	NNS
cord-296347-fanlvxqs	173	8	are	be	VBP
cord-296347-fanlvxqs	173	9	mainly	mainly	RB
cord-296347-fanlvxqs	173	10	cytosolic	cytosolic	JJ
cord-296347-fanlvxqs	173	11	and	and	CC
cord-296347-fanlvxqs	173	12	can	can	MD
cord-296347-fanlvxqs	173	13	recruit	recruit	VB
cord-296347-fanlvxqs	173	14	substrate	substrate	NN
cord-296347-fanlvxqs	173	15	adaptor	adaptor	NN
cord-296347-fanlvxqs	173	16	proteins	protein	NNS
cord-296347-fanlvxqs	173	17	,	,	,
cord-296347-fanlvxqs	173	18	the	the	DT
cord-296347-fanlvxqs	173	19	F	F	NNP
cord-296347-fanlvxqs	173	20	-	-	HYPH
cord-296347-fanlvxqs	173	21	boxes	box	NNS
cord-296347-fanlvxqs	173	22	,	,	,
cord-296347-fanlvxqs	173	23	with	with	IN
cord-296347-fanlvxqs	173	24	very	very	RB
cord-296347-fanlvxqs	173	25	diverse	diverse	JJ
cord-296347-fanlvxqs	173	26	substrate	substrate	NN
cord-296347-fanlvxqs	173	27	specificities	specificity	NNS
cord-296347-fanlvxqs	173	28	.	.	.
cord-296347-fanlvxqs	174	1	We	-PRON-	PRP
cord-296347-fanlvxqs	174	2	elaborate	elaborate	VBP
cord-296347-fanlvxqs	174	3	on	on	IN
cord-296347-fanlvxqs	174	4	Ub	Ub	NNP
cord-296347-fanlvxqs	174	5	E3	E3	NNP
cord-296347-fanlvxqs	174	6	ligases	ligase	NNS
cord-296347-fanlvxqs	174	7	to	to	IN
cord-296347-fanlvxqs	174	8	some	some	DT
cord-296347-fanlvxqs	174	9	extent	extent	NN
cord-296347-fanlvxqs	174	10	,	,	,
cord-296347-fanlvxqs	174	11	as	as	IN
cord-296347-fanlvxqs	174	12	they	-PRON-	PRP
cord-296347-fanlvxqs	174	13	are	be	VBP
cord-296347-fanlvxqs	174	14	key	key	JJ
cord-296347-fanlvxqs	174	15	players	player	NNS
cord-296347-fanlvxqs	174	16	in	in	IN
cord-296347-fanlvxqs	174	17	several	several	JJ
cord-296347-fanlvxqs	174	18	aspects	aspect	NNS
cord-296347-fanlvxqs	174	19	of	of	IN
cord-296347-fanlvxqs	174	20	the	the	DT
cord-296347-fanlvxqs	174	21	immune	immune	JJ
cord-296347-fanlvxqs	174	22	system	system	NN
cord-296347-fanlvxqs	174	23	,	,	,
cord-296347-fanlvxqs	174	24	including	include	VBG
cord-296347-fanlvxqs	174	25	immune	immune	JJ
cord-296347-fanlvxqs	174	26	evasion	evasion	NN
cord-296347-fanlvxqs	174	27	(	(	-LRB-
cord-296347-fanlvxqs	174	28	Liu	Liu	NNP
cord-296347-fanlvxqs	174	29	,	,	,
cord-296347-fanlvxqs	174	30	2004	2004	CD
cord-296347-fanlvxqs	174	31	)	)	-RRB-
cord-296347-fanlvxqs	174	32	and	and	CC
cord-296347-fanlvxqs	174	33	also	also	RB
cord-296347-fanlvxqs	174	34	in	in	IN
cord-296347-fanlvxqs	174	35	ER	ER	NNP
cord-296347-fanlvxqs	174	36	quality	quality	NN
cord-296347-fanlvxqs	174	37	control	control	NN
cord-296347-fanlvxqs	174	38	and	and	CC
cord-296347-fanlvxqs	174	39	degradation	degradation	NN
cord-296347-fanlvxqs	174	40	Kostova	Kostova	NNP
cord-296347-fanlvxqs	174	41	and	and	CC
cord-296347-fanlvxqs	174	42	Wolf	Wolf	NNP
cord-296347-fanlvxqs	174	43	,	,	,
cord-296347-fanlvxqs	174	44	2003	2003	CD
cord-296347-fanlvxqs	174	45	;	;	:
cord-296347-fanlvxqs	174	46	Romisch	Romisch	NNP
cord-296347-fanlvxqs	174	47	,	,	,
cord-296347-fanlvxqs	174	48	2005	2005	CD
cord-296347-fanlvxqs	174	49	)	)	-RRB-
cord-296347-fanlvxqs	174	50	,	,	,
cord-296347-fanlvxqs	174	51	that	that	IN
cord-296347-fanlvxqs	174	52	yields	yield	VBZ
cord-296347-fanlvxqs	174	53	to	to	IN
cord-296347-fanlvxqs	174	54	some	some	DT
cord-296347-fanlvxqs	174	55	of	of	IN
cord-296347-fanlvxqs	174	56	the	the	DT
cord-296347-fanlvxqs	174	57	ligands	ligand	NNS
cord-296347-fanlvxqs	174	58	on	on	IN
cord-296347-fanlvxqs	174	59	class	class	NN
cord-296347-fanlvxqs	174	60	I	-PRON-	PRP
cord-296347-fanlvxqs	174	61	MHC	MHC	NNP
cord-296347-fanlvxqs	174	62	products	product	NNS
cord-296347-fanlvxqs	174	63	.	.	.
cord-296347-fanlvxqs	175	1	E3	E3	NNP
cord-296347-fanlvxqs	175	2	ligases	ligase	NNS
cord-296347-fanlvxqs	175	3	can	can	MD
cord-296347-fanlvxqs	175	4	be	be	VB
cord-296347-fanlvxqs	175	5	divided	divide	VBN
cord-296347-fanlvxqs	175	6	into	into	IN
cord-296347-fanlvxqs	175	7	two	two	CD
cord-296347-fanlvxqs	175	8	broad	broad	JJ
cord-296347-fanlvxqs	175	9	classes	class	NNS
cord-296347-fanlvxqs	175	10	:	:	:
cord-296347-fanlvxqs	175	11	the	the	DT
cord-296347-fanlvxqs	175	12	homologous	homologous	JJ
cord-296347-fanlvxqs	175	13	to	to	IN
cord-296347-fanlvxqs	175	14	E6-AP	E6-AP	NNP
cord-296347-fanlvxqs	175	15	carboxyl	carboxyl	NN
cord-296347-fanlvxqs	175	16	terminus	terminus	NN
cord-296347-fanlvxqs	175	17	(	(	-LRB-
cord-296347-fanlvxqs	175	18	HECT)-domain	HECT)-domain	NNP
cord-296347-fanlvxqs	175	19	ligases	ligase	NNS
cord-296347-fanlvxqs	175	20	or	or	CC
cord-296347-fanlvxqs	175	21	the	the	DT
cord-296347-fanlvxqs	175	22	really	really	RB
cord-296347-fanlvxqs	175	23	interesting	interesting	JJ
cord-296347-fanlvxqs	175	24	new	new	JJ
cord-296347-fanlvxqs	175	25	gene	gene	NN
cord-296347-fanlvxqs	175	26	(	(	-LRB-
cord-296347-fanlvxqs	175	27	RING)-like	RING)-like	NNP
cord-296347-fanlvxqs	175	28	domain	domain	NN
cord-296347-fanlvxqs	175	29	ligases	ligase	NNS
cord-296347-fanlvxqs	175	30	.	.	.
cord-296347-fanlvxqs	176	1	The	the	DT
cord-296347-fanlvxqs	176	2	first	first	JJ
cord-296347-fanlvxqs	176	3	HECT	HECT	NNP
cord-296347-fanlvxqs	176	4	E3	E3	NNP
cord-296347-fanlvxqs	176	5	described	describe	VBN
cord-296347-fanlvxqs	176	6	,	,	,
cord-296347-fanlvxqs	176	7	E6-associated	e6-associate	VBN
cord-296347-fanlvxqs	176	8	protein	protein	NN
cord-296347-fanlvxqs	176	9	(	(	-LRB-
cord-296347-fanlvxqs	176	10	E6-AP	E6-AP	NNP
cord-296347-fanlvxqs	176	11	)	)	-RRB-
cord-296347-fanlvxqs	176	12	,	,	,
cord-296347-fanlvxqs	176	13	was	be	VBD
cord-296347-fanlvxqs	176	14	shown	show	VBN
cord-296347-fanlvxqs	176	15	to	to	TO
cord-296347-fanlvxqs	176	16	be	be	VB
cord-296347-fanlvxqs	176	17	required	require	VBN
cord-296347-fanlvxqs	176	18	for	for	IN
cord-296347-fanlvxqs	176	19	ubiquitination	ubiquitination	NN
cord-296347-fanlvxqs	176	20	and	and	CC
cord-296347-fanlvxqs	176	21	degradation	degradation	NN
cord-296347-fanlvxqs	176	22	of	of	IN
cord-296347-fanlvxqs	176	23	p53	p53	NN
cord-296347-fanlvxqs	176	24	,	,	,
cord-296347-fanlvxqs	176	25	mediated	mediate	VBN
cord-296347-fanlvxqs	176	26	by	by	IN
cord-296347-fanlvxqs	176	27	the	the	DT
cord-296347-fanlvxqs	176	28	human	human	JJ
cord-296347-fanlvxqs	176	29	papillomavirus	papillomavirus	NN
cord-296347-fanlvxqs	176	30	protein	protein	NN
cord-296347-fanlvxqs	176	31	E6	e6	NN
cord-296347-fanlvxqs	176	32	(	(	-LRB-
cord-296347-fanlvxqs	176	33	Scheffner	Scheffner	NNP
cord-296347-fanlvxqs	176	34	et	et	FW
cord-296347-fanlvxqs	176	35	al	al	NNP
cord-296347-fanlvxqs	176	36	.	.	NNP
cord-296347-fanlvxqs	176	37	,	,	,
cord-296347-fanlvxqs	176	38	1993	1993	CD
cord-296347-fanlvxqs	176	39	)	)	-RRB-
cord-296347-fanlvxqs	176	40	.	.	.
cord-296347-fanlvxqs	177	1	In	in	IN
cord-296347-fanlvxqs	177	2	HECT	HECT	NNP
cord-296347-fanlvxqs	177	3	E3s	e3s	NN
cord-296347-fanlvxqs	177	4	,	,	,
cord-296347-fanlvxqs	177	5	Ub	Ub	NNP
cord-296347-fanlvxqs	177	6	is	be	VBZ
cord-296347-fanlvxqs	177	7	transferred	transfer	VBN
cord-296347-fanlvxqs	177	8	from	from	IN
cord-296347-fanlvxqs	177	9	the	the	DT
cord-296347-fanlvxqs	177	10	E2	E2	NNP
cord-296347-fanlvxqs	177	11	to	to	IN
cord-296347-fanlvxqs	177	12	a	a	DT
cord-296347-fanlvxqs	177	13	conserved	conserve	VBN
cord-296347-fanlvxqs	177	14	cysteine	cysteine	NN
cord-296347-fanlvxqs	177	15	residue	residue	NN
cord-296347-fanlvxqs	177	16	in	in	IN
cord-296347-fanlvxqs	177	17	the	the	DT
cord-296347-fanlvxqs	177	18	HECT	HECT	NNP
cord-296347-fanlvxqs	177	19	domain	domain	NN
cord-296347-fanlvxqs	177	20	,	,	,
cord-296347-fanlvxqs	177	21	followed	follow	VBN
cord-296347-fanlvxqs	177	22	by	by	IN
cord-296347-fanlvxqs	177	23	attack	attack	NN
cord-296347-fanlvxqs	177	24	of	of	IN
cord-296347-fanlvxqs	177	25	this	this	DT
cord-296347-fanlvxqs	177	26	thioester	thioester	NN
cord-296347-fanlvxqs	177	27	by	by	IN
cord-296347-fanlvxqs	177	28	a	a	DT
cord-296347-fanlvxqs	177	29	lysine	lysine	NN
cord-296347-fanlvxqs	177	30	on	on	IN
cord-296347-fanlvxqs	177	31	the	the	DT
cord-296347-fanlvxqs	177	32	substrate	substrate	NN
cord-296347-fanlvxqs	177	33	(	(	-LRB-
cord-296347-fanlvxqs	177	34	Pickart	Pickart	NNP
cord-296347-fanlvxqs	177	35	,	,	,
cord-296347-fanlvxqs	177	36	2001	2001	CD
cord-296347-fanlvxqs	177	37	)	)	-RRB-
cord-296347-fanlvxqs	177	38	.	.	.
cord-296347-fanlvxqs	178	1	The	the	DT
cord-296347-fanlvxqs	178	2	RING	ring	NN
cord-296347-fanlvxqs	178	3	-	-	HYPH
cord-296347-fanlvxqs	178	4	CH	ch	NN
cord-296347-fanlvxqs	178	5	domain	domain	NN
cord-296347-fanlvxqs	178	6	is	be	VBZ
cord-296347-fanlvxqs	178	7	a	a	DT
cord-296347-fanlvxqs	178	8	ring	ring	NN
cord-296347-fanlvxqs	178	9	finger	finger	NN
cord-296347-fanlvxqs	178	10	motif	motif	NN
cord-296347-fanlvxqs	178	11	with	with	IN
cord-296347-fanlvxqs	178	12	a	a	DT
cord-296347-fanlvxqs	178	13	cysteine	cysteine	NN
cord-296347-fanlvxqs	178	14	residue	residue	NN
cord-296347-fanlvxqs	178	15	in	in	IN
cord-296347-fanlvxqs	178	16	the	the	DT
cord-296347-fanlvxqs	178	17	fourth	fourth	JJ
cord-296347-fanlvxqs	178	18	zinc	zinc	NN
cord-296347-fanlvxqs	178	19	-	-	HYPH
cord-296347-fanlvxqs	178	20	coordinating	coordinate	VBG
cord-296347-fanlvxqs	178	21	position	position	NN
cord-296347-fanlvxqs	178	22	and	and	CC
cord-296347-fanlvxqs	178	23	a	a	DT
cord-296347-fanlvxqs	178	24	histidine	histidine	NN
cord-296347-fanlvxqs	178	25	residue	residue	NN
cord-296347-fanlvxqs	178	26	in	in	IN
cord-296347-fanlvxqs	178	27	the	the	DT
cord-296347-fanlvxqs	178	28	fifth	fifth	NN
cord-296347-fanlvxqs	178	29	.	.	.
cord-296347-fanlvxqs	179	1	RING	ring	NN
cord-296347-fanlvxqs	179	2	-	-	HYPH
cord-296347-fanlvxqs	179	3	type	type	NN
cord-296347-fanlvxqs	179	4	E3s	e3s	NN
cord-296347-fanlvxqs	179	5	are	be	VBP
cord-296347-fanlvxqs	179	6	more	more	RBR
cord-296347-fanlvxqs	179	7	abundant	abundant	JJ
cord-296347-fanlvxqs	179	8	and	and	CC
cord-296347-fanlvxqs	179	9	do	do	VBP
cord-296347-fanlvxqs	179	10	not	not	RB
cord-296347-fanlvxqs	179	11	form	form	VB
cord-296347-fanlvxqs	179	12	an	an	DT
cord-296347-fanlvxqs	179	13	obligatory	obligatory	JJ
cord-296347-fanlvxqs	179	14	thioester	thioester	NN
cord-296347-fanlvxqs	179	15	intermediate	intermediate	JJ
cord-296347-fanlvxqs	179	16	with	with	IN
cord-296347-fanlvxqs	179	17	Ub	Ub	NNP
cord-296347-fanlvxqs	179	18	;	;	:
cord-296347-fanlvxqs	179	19	rather	rather	RB
cord-296347-fanlvxqs	179	20	they	-PRON-	PRP
cord-296347-fanlvxqs	179	21	bring	bring	VBP
cord-296347-fanlvxqs	179	22	the	the	DT
cord-296347-fanlvxqs	179	23	Ub	Ub	NNP
cord-296347-fanlvxqs	179	24	-	-	HYPH
cord-296347-fanlvxqs	179	25	loaded	loaded	JJ
cord-296347-fanlvxqs	179	26	E2s	E2s	NNP
cord-296347-fanlvxqs	179	27	and	and	CC
cord-296347-fanlvxqs	179	28	the	the	DT
cord-296347-fanlvxqs	179	29	substrate	substrate	NN
cord-296347-fanlvxqs	179	30	into	into	IN
cord-296347-fanlvxqs	179	31	proximity	proximity	NN
cord-296347-fanlvxqs	179	32	,	,	,
cord-296347-fanlvxqs	179	33	thus	thus	RB
cord-296347-fanlvxqs	179	34	facilitating	facilitate	VBG
cord-296347-fanlvxqs	179	35	the	the	DT
cord-296347-fanlvxqs	179	36	Ub	Ub	NNP
cord-296347-fanlvxqs	179	37	transfer	transfer	NN
cord-296347-fanlvxqs	179	38	from	from	IN
cord-296347-fanlvxqs	179	39	the	the	DT
cord-296347-fanlvxqs	179	40	E2	E2	NNP
cord-296347-fanlvxqs	179	41	to	to	IN
cord-296347-fanlvxqs	179	42	the	the	DT
cord-296347-fanlvxqs	179	43	substrate	substrate	NN
cord-296347-fanlvxqs	179	44	(	(	-LRB-
cord-296347-fanlvxqs	179	45	Pickart	Pickart	NNP
cord-296347-fanlvxqs	179	46	,	,	,
cord-296347-fanlvxqs	179	47	2001	2001	CD
cord-296347-fanlvxqs	179	48	)	)	-RRB-
cord-296347-fanlvxqs	179	49	.	.	.
cord-296347-fanlvxqs	180	1	RING	ring	NN
cord-296347-fanlvxqs	180	2	-	-	HYPH
cord-296347-fanlvxqs	180	3	type	type	NN
cord-296347-fanlvxqs	180	4	E3s	e3s	NN
cord-296347-fanlvxqs	180	5	can	can	MD
cord-296347-fanlvxqs	180	6	be	be	VB
cord-296347-fanlvxqs	180	7	single	single	JJ
cord-296347-fanlvxqs	180	8	subunit	subunit	NN
cord-296347-fanlvxqs	180	9	E3s	e3s	NN
cord-296347-fanlvxqs	180	10	,	,	,
cord-296347-fanlvxqs	180	11	which	which	WDT
cord-296347-fanlvxqs	180	12	have	have	VBP
cord-296347-fanlvxqs	180	13	both	both	CC
cord-296347-fanlvxqs	180	14	a	a	DT
cord-296347-fanlvxqs	180	15	RING	ring	NN
cord-296347-fanlvxqs	180	16	-	-	HYPH
cord-296347-fanlvxqs	180	17	finger	finger	NN
cord-296347-fanlvxqs	180	18	domain	domain	NN
cord-296347-fanlvxqs	180	19	and	and	CC
cord-296347-fanlvxqs	180	20	substrate	substrate	NN
cord-296347-fanlvxqs	180	21	recruitment	recruitment	NN
cord-296347-fanlvxqs	180	22	domain(s	domain(s	NNP
cord-296347-fanlvxqs	180	23	)	)	-RRB-
cord-296347-fanlvxqs	180	24	on	on	IN
cord-296347-fanlvxqs	180	25	the	the	DT
cord-296347-fanlvxqs	180	26	same	same	JJ
cord-296347-fanlvxqs	180	27	protein	protein	NN
cord-296347-fanlvxqs	180	28	,	,	,
cord-296347-fanlvxqs	180	29	like	like	IN
cord-296347-fanlvxqs	180	30	MDM2	MDM2	NNP
cord-296347-fanlvxqs	180	31	,	,	,
cord-296347-fanlvxqs	180	32	a	a	DT
cord-296347-fanlvxqs	180	33	key	key	JJ
cord-296347-fanlvxqs	180	34	regulator	regulator	NN
cord-296347-fanlvxqs	180	35	of	of	IN
cord-296347-fanlvxqs	180	36	p53	p53	NN
cord-296347-fanlvxqs	180	37	.	.	.
cord-296347-fanlvxqs	181	1	Multisubunit	Multisubunit	NNP
cord-296347-fanlvxqs	181	2	E3s	e3s	PRP
cord-296347-fanlvxqs	181	3	include	include	VBP
cord-296347-fanlvxqs	181	4	the	the	DT
cord-296347-fanlvxqs	181	5	very	very	RB
cord-296347-fanlvxqs	181	6	diverse	diverse	JJ
cord-296347-fanlvxqs	181	7	Cullin	Cullin	NNP
cord-296347-fanlvxqs	181	8	-	-	HYPH
cord-296347-fanlvxqs	181	9	RING	ring	NN
cord-296347-fanlvxqs	181	10	ligases	ligase	NNS
cord-296347-fanlvxqs	181	11	(	(	-LRB-
cord-296347-fanlvxqs	181	12	CRLs	CRLs	NNP
cord-296347-fanlvxqs	181	13	)	)	-RRB-
cord-296347-fanlvxqs	181	14	(	(	-LRB-
cord-296347-fanlvxqs	181	15	Petroski	Petroski	NNP
cord-296347-fanlvxqs	181	16	and	and	CC
cord-296347-fanlvxqs	181	17	Deshaies	Deshaies	NNP
cord-296347-fanlvxqs	181	18	,	,	,
cord-296347-fanlvxqs	181	19	2005	2005	CD
cord-296347-fanlvxqs	181	20	)	)	-RRB-
cord-296347-fanlvxqs	181	21	.	.	.
cord-296347-fanlvxqs	182	1	CRLs	CRLs	NNP
cord-296347-fanlvxqs	182	2	are	be	VBP
cord-296347-fanlvxqs	182	3	composed	compose	VBN
cord-296347-fanlvxqs	182	4	of	of	IN
cord-296347-fanlvxqs	182	5	a	a	DT
cord-296347-fanlvxqs	182	6	catalytic	catalytic	JJ
cord-296347-fanlvxqs	182	7	core	core	NN
cord-296347-fanlvxqs	182	8	that	that	WDT
cord-296347-fanlvxqs	182	9	recruits	recruit	VBZ
cord-296347-fanlvxqs	182	10	the	the	DT
cord-296347-fanlvxqs	182	11	Ub	Ub	NNP
cord-296347-fanlvxqs	182	12	-	-	HYPH
cord-296347-fanlvxqs	182	13	loaded	load	VBN
cord-296347-fanlvxqs	182	14	E2-formed	e2-forme	VBN
cord-296347-fanlvxqs	182	15	by	by	IN
cord-296347-fanlvxqs	182	16	a	a	DT
cord-296347-fanlvxqs	182	17	nucleating	nucleate	VBG
cord-296347-fanlvxqs	182	18	Cullin	Cullin	NNP
cord-296347-fanlvxqs	182	19	protein	protein	NN
cord-296347-fanlvxqs	182	20	and	and	CC
cord-296347-fanlvxqs	182	21	a	a	DT
cord-296347-fanlvxqs	182	22	RING	ring	NN
cord-296347-fanlvxqs	182	23	finger	finger	NN
cord-296347-fanlvxqs	182	24	protein	protein	NN
cord-296347-fanlvxqs	182	25	-	-	:
cord-296347-fanlvxqs	182	26	as	as	RB
cord-296347-fanlvxqs	182	27	well	well	RB
cord-296347-fanlvxqs	182	28	as	as	IN
cord-296347-fanlvxqs	182	29	a	a	DT
cord-296347-fanlvxqs	182	30	substrate	substrate	NN
cord-296347-fanlvxqs	182	31	recognition	recognition	NN
cord-296347-fanlvxqs	182	32	complex	complex	NN
cord-296347-fanlvxqs	182	33	.	.	.
cord-296347-fanlvxqs	183	1	The	the	DT
cord-296347-fanlvxqs	183	2	archetypal	archetypal	JJ
cord-296347-fanlvxqs	183	3	CRLs	crl	NNS
cord-296347-fanlvxqs	183	4	are	be	VBP
cord-296347-fanlvxqs	183	5	the	the	DT
cord-296347-fanlvxqs	183	6	Skp-1-Cullin-1-F	Skp-1-Cullin-1-F	NNP
cord-296347-fanlvxqs	183	7	-	-	HYPH
cord-296347-fanlvxqs	183	8	box	box	NN
cord-296347-fanlvxqs	183	9	protein	protein	NN
cord-296347-fanlvxqs	183	10	complexes	complex	NNS
cord-296347-fanlvxqs	183	11	or	or	CC
cord-296347-fanlvxqs	183	12	SCF	SCF	NNP
cord-296347-fanlvxqs	183	13	E3s	e3s	NN
cord-296347-fanlvxqs	183	14	.	.	.
cord-296347-fanlvxqs	184	1	The	the	DT
cord-296347-fanlvxqs	184	2	Cullin	Cullin	NNP
cord-296347-fanlvxqs	184	3	subunit	subunit	NN
cord-296347-fanlvxqs	184	4	(	(	-LRB-
cord-296347-fanlvxqs	184	5	any	any	DT
cord-296347-fanlvxqs	184	6	one	one	CD
cord-296347-fanlvxqs	184	7	of	of	IN
cord-296347-fanlvxqs	184	8	Cullin-1	Cullin-1	NNP
cord-296347-fanlvxqs	184	9	,	,	,
cord-296347-fanlvxqs	184	10	-2	-2	NNP
cord-296347-fanlvxqs	184	11	,	,	,
cord-296347-fanlvxqs	184	12	-3	-3	NNP
cord-296347-fanlvxqs	184	13	,	,	,
cord-296347-fanlvxqs	184	14	-4A	-4a	ADD
cord-296347-fanlvxqs	184	15	,	,	,
cord-296347-fanlvxqs	184	16	-4B	-4B	NNP
cord-296347-fanlvxqs	184	17	,	,	,
cord-296347-fanlvxqs	184	18	-5	-5	NNP
cord-296347-fanlvxqs	184	19	,	,	,
cord-296347-fanlvxqs	184	20	or	or	CC
cord-296347-fanlvxqs	184	21	-7	-7	NNP
cord-296347-fanlvxqs	184	22	)	)	-RRB-
cord-296347-fanlvxqs	184	23	forms	form	VBZ
cord-296347-fanlvxqs	184	24	an	an	DT
cord-296347-fanlvxqs	184	25	elongated	elongated	JJ
cord-296347-fanlvxqs	184	26	bent	bent	JJ
cord-296347-fanlvxqs	184	27	backbone	backbone	NN
cord-296347-fanlvxqs	184	28	for	for	IN
cord-296347-fanlvxqs	184	29	the	the	DT
cord-296347-fanlvxqs	184	30	multisubunit	multisubunit	NNP
cord-296347-fanlvxqs	184	31	ligase	ligase	NN
cord-296347-fanlvxqs	184	32	.	.	.
cord-296347-fanlvxqs	185	1	The	the	DT
cord-296347-fanlvxqs	185	2	Cullin	Cullin	NNP
cord-296347-fanlvxqs	185	3	N	N	NNP
cord-296347-fanlvxqs	185	4	-	-	HYPH
cord-296347-fanlvxqs	185	5	terminus	terminus	NN
cord-296347-fanlvxqs	185	6	binds	bind	VBZ
cord-296347-fanlvxqs	185	7	the	the	DT
cord-296347-fanlvxqs	185	8	S	s	NN
cord-296347-fanlvxqs	185	9	-	-	HYPH
cord-296347-fanlvxqs	185	10	phase	phase	NN
cord-296347-fanlvxqs	185	11	kinase	kinase	NN
cord-296347-fanlvxqs	185	12	-	-	HYPH
cord-296347-fanlvxqs	185	13	related	relate	VBN
cord-296347-fanlvxqs	185	14	protein-1	protein-1	NNP
cord-296347-fanlvxqs	185	15	(	(	-LRB-
cord-296347-fanlvxqs	185	16	Skp-1	Skp-1	NNP
cord-296347-fanlvxqs	185	17	)	)	-RRB-
cord-296347-fanlvxqs	185	18	,	,	,
cord-296347-fanlvxqs	185	19	an	an	DT
cord-296347-fanlvxqs	185	20	adaptor	adaptor	NN
cord-296347-fanlvxqs	185	21	that	that	WDT
cord-296347-fanlvxqs	185	22	recruits	recruit	VBZ
cord-296347-fanlvxqs	185	23	any	any	DT
cord-296347-fanlvxqs	185	24	one	one	CD
cord-296347-fanlvxqs	185	25	of	of	IN
cord-296347-fanlvxqs	185	26	a	a	DT
cord-296347-fanlvxqs	185	27	number	number	NN
cord-296347-fanlvxqs	185	28	of	of	IN
cord-296347-fanlvxqs	185	29	substrate	substrate	NN
cord-296347-fanlvxqs	185	30	-	-	HYPH
cord-296347-fanlvxqs	185	31	specific	specific	JJ
cord-296347-fanlvxqs	185	32	adaptor	adaptor	NN
cord-296347-fanlvxqs	185	33	subunits	subunit	NNS
cord-296347-fanlvxqs	185	34	called	call	VBN
cord-296347-fanlvxqs	185	35	F	F	NNP
cord-296347-fanlvxqs	185	36	-	-	HYPH
cord-296347-fanlvxqs	185	37	box	box	NN
cord-296347-fanlvxqs	185	38	proteins	protein	NNS
cord-296347-fanlvxqs	185	39	.	.	.
cord-296347-fanlvxqs	186	1	The	the	DT
cord-296347-fanlvxqs	186	2	F	F	NNP
cord-296347-fanlvxqs	186	3	-	-	HYPH
cord-296347-fanlvxqs	186	4	box	box	NN
cord-296347-fanlvxqs	186	5	protein	protein	NN
cord-296347-fanlvxqs	186	6	is	be	VBZ
cord-296347-fanlvxqs	186	7	the	the	DT
cord-296347-fanlvxqs	186	8	main	main	JJ
cord-296347-fanlvxqs	186	9	determinant	determinant	NN
cord-296347-fanlvxqs	186	10	in	in	IN
cord-296347-fanlvxqs	186	11	substrate	substrate	JJ
cord-296347-fanlvxqs	186	12	specificity	specificity	NN
cord-296347-fanlvxqs	186	13	,	,	,
cord-296347-fanlvxqs	186	14	as	as	IN
cord-296347-fanlvxqs	186	15	it	-PRON-	PRP
cord-296347-fanlvxqs	186	16	binds	bind	VBZ
cord-296347-fanlvxqs	186	17	the	the	DT
cord-296347-fanlvxqs	186	18	substrate	substrate	NN
cord-296347-fanlvxqs	186	19	through	through	IN
cord-296347-fanlvxqs	186	20	its	-PRON-	PRP$
cord-296347-fanlvxqs	186	21	particular	particular	JJ
cord-296347-fanlvxqs	186	22	substrate	substrate	NN
cord-296347-fanlvxqs	186	23	recognition	recognition	NN
cord-296347-fanlvxqs	186	24	domain	domain	NN
cord-296347-fanlvxqs	186	25	(	(	-LRB-
cord-296347-fanlvxqs	186	26	Jin	Jin	NNP
cord-296347-fanlvxqs	186	27	et	et	NNP
cord-296347-fanlvxqs	186	28	al	al	NNP
cord-296347-fanlvxqs	186	29	.	.	NNP
cord-296347-fanlvxqs	186	30	,	,	,
cord-296347-fanlvxqs	186	31	2004a	2004a	CD
cord-296347-fanlvxqs	186	32	)	)	-RRB-
cord-296347-fanlvxqs	186	33	,	,	,
cord-296347-fanlvxqs	186	34	although	although	IN
cord-296347-fanlvxqs	186	35	the	the	DT
cord-296347-fanlvxqs	186	36	RING	RING	NNP
cord-296347-fanlvxqs	186	37	box	box	NN
cord-296347-fanlvxqs	186	38	protein	protein	NN
cord-296347-fanlvxqs	186	39	may	may	MD
cord-296347-fanlvxqs	186	40	participate	participate	VB
cord-296347-fanlvxqs	186	41	(	(	-LRB-
cord-296347-fanlvxqs	186	42	Jin	Jin	NNP
cord-296347-fanlvxqs	186	43	and	and	CC
cord-296347-fanlvxqs	186	44	Harper	Harper	NNP
cord-296347-fanlvxqs	186	45	,	,	,
cord-296347-fanlvxqs	186	46	2002	2002	CD
cord-296347-fanlvxqs	186	47	)	)	-RRB-
cord-296347-fanlvxqs	186	48	.	.	.
cord-296347-fanlvxqs	187	1	The	the	DT
cord-296347-fanlvxqs	187	2	Cullin	Cullin	NNP
cord-296347-fanlvxqs	187	3	N	N	NNP
cord-296347-fanlvxqs	187	4	-	-	HYPH
cord-296347-fanlvxqs	187	5	terminus	terminus	NN
cord-296347-fanlvxqs	187	6	binds	bind	VBZ
cord-296347-fanlvxqs	187	7	the	the	DT
cord-296347-fanlvxqs	187	8	catalytic	catalytic	JJ
cord-296347-fanlvxqs	187	9	core	core	NN
cord-296347-fanlvxqs	187	10	composed	compose	VBN
cord-296347-fanlvxqs	187	11	of	of	IN
cord-296347-fanlvxqs	187	12	the	the	DT
cord-296347-fanlvxqs	187	13	RING	ring	NN
cord-296347-fanlvxqs	187	14	-	-	HYPH
cord-296347-fanlvxqs	187	15	box	box	NN
cord-296347-fanlvxqs	187	16	(	(	-LRB-
cord-296347-fanlvxqs	187	17	Rbx	rbx	NN
cord-296347-fanlvxqs	187	18	)	)	-RRB-
cord-296347-fanlvxqs	187	19	protein	protein	NN
cord-296347-fanlvxqs	187	20	with	with	IN
cord-296347-fanlvxqs	187	21	its	-PRON-	PRP$
cord-296347-fanlvxqs	187	22	associated	associated	JJ
cord-296347-fanlvxqs	187	23	Ub	Ub	NNP
cord-296347-fanlvxqs	187	24	-	-	HYPH
cord-296347-fanlvxqs	187	25	loaded	loaded	JJ
cord-296347-fanlvxqs	187	26	E2	e2	NN
cord-296347-fanlvxqs	187	27	.	.	.
cord-296347-fanlvxqs	188	1	This	this	DT
cord-296347-fanlvxqs	188	2	arrangement	arrangement	NN
cord-296347-fanlvxqs	188	3	allows	allow	VBZ
cord-296347-fanlvxqs	188	4	the	the	DT
cord-296347-fanlvxqs	188	5	F	F	NNP
cord-296347-fanlvxqs	188	6	-	-	HYPH
cord-296347-fanlvxqs	188	7	box	box	NNP
cord-296347-fanlvxqs	188	8	protein	protein	NN
cord-296347-fanlvxqs	188	9	to	to	TO
cord-296347-fanlvxqs	188	10	bring	bring	VB
cord-296347-fanlvxqs	188	11	its	-PRON-	PRP$
cord-296347-fanlvxqs	188	12	bound	bind	VBN
cord-296347-fanlvxqs	188	13	substrate	substrate	NN
cord-296347-fanlvxqs	188	14	close	close	RB
cord-296347-fanlvxqs	188	15	to	to	IN
cord-296347-fanlvxqs	188	16	the	the	DT
cord-296347-fanlvxqs	188	17	ubiquitination	ubiquitination	JJ
cord-296347-fanlvxqs	188	18	machinery	machinery	NN
cord-296347-fanlvxqs	188	19	of	of	IN
cord-296347-fanlvxqs	188	20	the	the	DT
cord-296347-fanlvxqs	188	21	complex	complex	JJ
cord-296347-fanlvxqs	188	22	(	(	-LRB-
cord-296347-fanlvxqs	188	23	Fig	Fig	NNP
cord-296347-fanlvxqs	188	24	.	.	.
cord-296347-fanlvxqs	188	25	2B	2b	CD
cord-296347-fanlvxqs	188	26	)	)	-RRB-
cord-296347-fanlvxqs	188	27	.	.	.
cord-296347-fanlvxqs	189	1	Phosphorylation	phosphorylation	NN
cord-296347-fanlvxqs	189	2	of	of	IN
cord-296347-fanlvxqs	189	3	the	the	DT
cord-296347-fanlvxqs	189	4	substrate	substrate	NN
cord-296347-fanlvxqs	189	5	very	very	RB
cord-296347-fanlvxqs	189	6	often	often	RB
cord-296347-fanlvxqs	189	7	regulates	regulate	VBZ
cord-296347-fanlvxqs	189	8	the	the	DT
cord-296347-fanlvxqs	189	9	F	F	NNP
cord-296347-fanlvxqs	189	10	-	-	HYPH
cord-296347-fanlvxqs	189	11	box	box	NNP
cord-296347-fanlvxqs	189	12	protein	protein	NN
cord-296347-fanlvxqs	189	13	-	-	HYPH
cord-296347-fanlvxqs	189	14	substrate	substrate	NN
cord-296347-fanlvxqs	189	15	interaction	interaction	NN
cord-296347-fanlvxqs	189	16	,	,	,
cord-296347-fanlvxqs	189	17	converting	convert	VBG
cord-296347-fanlvxqs	189	18	the	the	DT
cord-296347-fanlvxqs	189	19	substrate	substrate	NN
cord-296347-fanlvxqs	189	20	into	into	IN
cord-296347-fanlvxqs	189	21	a	a	DT
cord-296347-fanlvxqs	189	22	form	form	NN
cord-296347-fanlvxqs	189	23	susceptible	susceptible	JJ
cord-296347-fanlvxqs	189	24	to	to	IN
cord-296347-fanlvxqs	189	25	E3	e3	NN
cord-296347-fanlvxqs	189	26	activity	activity	NN
cord-296347-fanlvxqs	189	27	,	,	,
cord-296347-fanlvxqs	189	28	adding	add	VBG
cord-296347-fanlvxqs	189	29	an	an	DT
cord-296347-fanlvxqs	189	30	extra	extra	JJ
cord-296347-fanlvxqs	189	31	layer	layer	NN
cord-296347-fanlvxqs	189	32	of	of	IN
cord-296347-fanlvxqs	189	33	control	control	NN
cord-296347-fanlvxqs	189	34	to	to	IN
cord-296347-fanlvxqs	189	35	the	the	DT
cord-296347-fanlvxqs	189	36	process	process	NN
cord-296347-fanlvxqs	189	37	(	(	-LRB-
cord-296347-fanlvxqs	189	38	Joazeiro	Joazeiro	NNP
cord-296347-fanlvxqs	189	39	and	and	CC
cord-296347-fanlvxqs	189	40	Weissman	Weissman	NNP
cord-296347-fanlvxqs	189	41	,	,	,
cord-296347-fanlvxqs	189	42	2000	2000	CD
cord-296347-fanlvxqs	189	43	;	;	:
cord-296347-fanlvxqs	189	44	Schulman	Schulman	NNP
cord-296347-fanlvxqs	189	45	et	et	NNP
cord-296347-fanlvxqs	189	46	al	al	NNP
cord-296347-fanlvxqs	189	47	.	.	.
cord-296347-fanlvxqs	190	1	,	,	,
cord-296347-fanlvxqs	190	2	2000	2000	CD
cord-296347-fanlvxqs	190	3	;	;	:
cord-296347-fanlvxqs	190	4	Zheng	Zheng	NNP
cord-296347-fanlvxqs	190	5	et	et	NNP
cord-296347-fanlvxqs	190	6	al	al	NNP
cord-296347-fanlvxqs	190	7	.	.	NNP
cord-296347-fanlvxqs	190	8	,	,	,
cord-296347-fanlvxqs	190	9	2002	2002	CD
cord-296347-fanlvxqs	190	10	)	)	-RRB-
cord-296347-fanlvxqs	190	11	.	.	.
cord-296347-fanlvxqs	191	1	CRLs	CRLs	NNPS
cord-296347-fanlvxqs	191	2	assemble	assemble	VBP
cord-296347-fanlvxqs	191	3	with	with	IN
cord-296347-fanlvxqs	191	4	numerous	numerous	JJ
cord-296347-fanlvxqs	191	5	substrate	substrate	NN
cord-296347-fanlvxqs	191	6	receptors	receptor	NNS
cord-296347-fanlvxqs	191	7	.	.	.
cord-296347-fanlvxqs	192	1	Cullins	Cullins	NNP
cord-296347-fanlvxqs	192	2	2	2	CD
cord-296347-fanlvxqs	192	3	and	and	CC
cord-296347-fanlvxqs	192	4	5	5	CD
cord-296347-fanlvxqs	192	5	,	,	,
cord-296347-fanlvxqs	192	6	for	for	IN
cord-296347-fanlvxqs	192	7	example	example	NN
cord-296347-fanlvxqs	192	8	,	,	,
cord-296347-fanlvxqs	192	9	recruit	recruit	VB
cord-296347-fanlvxqs	192	10	substrates	substrate	NNS
cord-296347-fanlvxqs	192	11	through	through	IN
cord-296347-fanlvxqs	192	12	suppressor	suppressor	NN
cord-296347-fanlvxqs	192	13	of	of	IN
cord-296347-fanlvxqs	192	14	cytokine	cytokine	NN
cord-296347-fanlvxqs	192	15	signaling	signal	VBG
cord-296347-fanlvxqs	192	16	/	/	SYM
cord-296347-fanlvxqs	192	17	elongin	elongin	NNP
cord-296347-fanlvxqs	192	18	-	-	HYPH
cord-296347-fanlvxqs	192	19	BC	BC	NNP
cord-296347-fanlvxqs	192	20	(	(	-LRB-
cord-296347-fanlvxqs	192	21	SOCS	SOCS	NNP
cord-296347-fanlvxqs	192	22	/	/	SYM
cord-296347-fanlvxqs	192	23	BC	BC	NNP
cord-296347-fanlvxqs	192	24	)	)	-RRB-
cord-296347-fanlvxqs	192	25	boxes	box	NNS
cord-296347-fanlvxqs	192	26	and	and	CC
cord-296347-fanlvxqs	192	27	form	form	VB
cord-296347-fanlvxqs	192	28	the	the	DT
cord-296347-fanlvxqs	192	29	so	so	RB
cord-296347-fanlvxqs	192	30	-	-	HYPH
cord-296347-fanlvxqs	192	31	called	call	VBN
cord-296347-fanlvxqs	192	32	SCF2s	SCF2s	NNP
cord-296347-fanlvxqs	192	33	and	and	CC
cord-296347-fanlvxqs	192	34	SCF5s	SCF5s	NNP
cord-296347-fanlvxqs	192	35	complexes	complex	NNS
cord-296347-fanlvxqs	192	36	.	.	.
cord-296347-fanlvxqs	193	1	In	in	IN
cord-296347-fanlvxqs	193	2	SCF2s	SCF2s	NNP
cord-296347-fanlvxqs	193	3	and	and	CC
cord-296347-fanlvxqs	193	4	SCF5s	SCF5s	NNP
cord-296347-fanlvxqs	193	5	,	,	,
cord-296347-fanlvxqs	193	6	Skp-1	Skp-1	NNP
cord-296347-fanlvxqs	193	7	is	be	VBZ
cord-296347-fanlvxqs	193	8	substituted	substitute	VBN
cord-296347-fanlvxqs	193	9	by	by	IN
cord-296347-fanlvxqs	193	10	the	the	DT
cord-296347-fanlvxqs	193	11	Skp-1-like	Skp-1-like	NNP
cord-296347-fanlvxqs	193	12	protein	protein	NN
cord-296347-fanlvxqs	193	13	elongin	elongin	NN
cord-296347-fanlvxqs	193	14	C	C	NNP
cord-296347-fanlvxqs	193	15	which	which	WDT
cord-296347-fanlvxqs	193	16	binds	bind	VBZ
cord-296347-fanlvxqs	193	17	the	the	DT
cord-296347-fanlvxqs	193	18	Ub	Ub	NNP
cord-296347-fanlvxqs	193	19	-	-	HYPH
cord-296347-fanlvxqs	193	20	like	like	JJ
cord-296347-fanlvxqs	193	21	elongin	elongin	NNP
cord-296347-fanlvxqs	193	22	B	B	NNP
cord-296347-fanlvxqs	193	23	that	that	WDT
cord-296347-fanlvxqs	193	24	binds	bind	VBZ
cord-296347-fanlvxqs	193	25	the	the	DT
cord-296347-fanlvxqs	193	26	substrate	substrate	JJ
cord-296347-fanlvxqs	193	27	adaptor	adaptor	NN
cord-296347-fanlvxqs	193	28	subunit	subunit	NN
cord-296347-fanlvxqs	193	29	(	(	-LRB-
cord-296347-fanlvxqs	193	30	Petroski	Petroski	NNP
cord-296347-fanlvxqs	193	31	and	and	CC
cord-296347-fanlvxqs	193	32	Deshaies	Deshaies	NNP
cord-296347-fanlvxqs	193	33	,	,	,
cord-296347-fanlvxqs	193	34	2005	2005	CD
cord-296347-fanlvxqs	193	35	)	)	-RRB-
cord-296347-fanlvxqs	193	36	.	.	.
cord-296347-fanlvxqs	194	1	Many	many	JJ
cord-296347-fanlvxqs	194	2	of	of	IN
cord-296347-fanlvxqs	194	3	these	these	DT
cord-296347-fanlvxqs	194	4	E3	E3	NNP
cord-296347-fanlvxqs	194	5	complexes	complex	NNS
cord-296347-fanlvxqs	194	6	have	have	VBP
cord-296347-fanlvxqs	194	7	important	important	JJ
cord-296347-fanlvxqs	194	8	roles	role	NNS
cord-296347-fanlvxqs	194	9	in	in	IN
cord-296347-fanlvxqs	194	10	the	the	DT
cord-296347-fanlvxqs	194	11	immune	immune	JJ
cord-296347-fanlvxqs	194	12	system	system	NN
cord-296347-fanlvxqs	194	13	(	(	-LRB-
cord-296347-fanlvxqs	194	14	Liu	Liu	NNP
cord-296347-fanlvxqs	194	15	,	,	,
cord-296347-fanlvxqs	194	16	2004	2004	CD
cord-296347-fanlvxqs	194	17	;	;	:
cord-296347-fanlvxqs	194	18	Liu	Liu	NNP
cord-296347-fanlvxqs	194	19	et	et	NNP
cord-296347-fanlvxqs	194	20	al	al	NNP
cord-296347-fanlvxqs	194	21	.	.	NNP
cord-296347-fanlvxqs	194	22	,	,	,
cord-296347-fanlvxqs	194	23	2005	2005	CD
cord-296347-fanlvxqs	194	24	)	)	-RRB-
cord-296347-fanlvxqs	194	25	.	.	.
cord-296347-fanlvxqs	195	1	The	the	DT
cord-296347-fanlvxqs	195	2	nuclear	nuclear	JJ
cord-296347-fanlvxqs	195	3	factor	factor	NN
cord-296347-fanlvxqs	195	4	-	-	HYPH
cord-296347-fanlvxqs	195	5	kB	kB	NNP
cord-296347-fanlvxqs	196	1	(	(	-LRB-
cord-296347-fanlvxqs	196	2	NF	NF	NNP
cord-296347-fanlvxqs	196	3	-	-	HYPH
cord-296347-fanlvxqs	196	4	kB	kB	NNP
cord-296347-fanlvxqs	196	5	)	)	-RRB-
cord-296347-fanlvxqs	196	6	transcription	transcription	NN
cord-296347-fanlvxqs	196	7	factor	factor	NN
cord-296347-fanlvxqs	196	8	is	be	VBZ
cord-296347-fanlvxqs	196	9	a	a	DT
cord-296347-fanlvxqs	196	10	master	master	NN
cord-296347-fanlvxqs	196	11	organizer	organizer	NN
cord-296347-fanlvxqs	196	12	of	of	IN
cord-296347-fanlvxqs	196	13	both	both	DT
cord-296347-fanlvxqs	196	14	innate	innate	JJ
cord-296347-fanlvxqs	196	15	and	and	CC
cord-296347-fanlvxqs	196	16	adaptive	adaptive	JJ
cord-296347-fanlvxqs	196	17	immunity	immunity	NN
cord-296347-fanlvxqs	196	18	.	.	.
cord-296347-fanlvxqs	197	1	NF	NF	NNP
cord-296347-fanlvxqs	197	2	-	-	HYPH
cord-296347-fanlvxqs	197	3	kB	kB	NNP
cord-296347-fanlvxqs	197	4	is	be	VBZ
cord-296347-fanlvxqs	197	5	activated	activate	VBN
cord-296347-fanlvxqs	197	6	in	in	IN
cord-296347-fanlvxqs	197	7	response	response	NN
cord-296347-fanlvxqs	197	8	to	to	IN
cord-296347-fanlvxqs	197	9	TLR	TLR	NNP
cord-296347-fanlvxqs	197	10	signaling	signal	VBG
cord-296347-fanlvxqs	197	11	on	on	IN
cord-296347-fanlvxqs	197	12	recognition	recognition	NN
cord-296347-fanlvxqs	197	13	of	of	IN
cord-296347-fanlvxqs	197	14	pathogen	pathogen	NN
cord-296347-fanlvxqs	197	15	-	-	HYPH
cord-296347-fanlvxqs	197	16	associated	associate	VBN
cord-296347-fanlvxqs	197	17	molecules	molecule	NNS
cord-296347-fanlvxqs	197	18	like	like	IN
cord-296347-fanlvxqs	197	19	bacterial	bacterial	JJ
cord-296347-fanlvxqs	197	20	peptidoglycan	peptidoglycan	NN
cord-296347-fanlvxqs	197	21	in	in	IN
cord-296347-fanlvxqs	197	22	a	a	DT
cord-296347-fanlvxqs	197	23	process	process	NN
cord-296347-fanlvxqs	197	24	that	that	WDT
cord-296347-fanlvxqs	197	25	is	be	VBZ
cord-296347-fanlvxqs	197	26	crucially	crucially	RB
cord-296347-fanlvxqs	197	27	dependent	dependent	JJ
cord-296347-fanlvxqs	197	28	on	on	IN
cord-296347-fanlvxqs	197	29	ubiquitination	ubiquitination	NN
cord-296347-fanlvxqs	197	30	.	.	.
cord-296347-fanlvxqs	198	1	One	one	CD
cord-296347-fanlvxqs	198	2	of	of	IN
cord-296347-fanlvxqs	198	3	the	the	DT
cord-296347-fanlvxqs	198	4	steps	step	NNS
cord-296347-fanlvxqs	198	5	requires	require	VBZ
cord-296347-fanlvxqs	198	6	the	the	DT
cord-296347-fanlvxqs	198	7	cytosolic	cytosolic	JJ
cord-296347-fanlvxqs	198	8	SCF	scf	NN
cord-296347-fanlvxqs	198	9	b	b	NNP
cord-296347-fanlvxqs	198	10	-	-	:
cord-296347-fanlvxqs	198	11	TrCP	TrCP	NNP
cord-296347-fanlvxqs	198	12	E3	E3	NNP
cord-296347-fanlvxqs	198	13	complex	complex	NN
cord-296347-fanlvxqs	198	14	.	.	.
cord-296347-fanlvxqs	199	1	The	the	DT
cord-296347-fanlvxqs	199	2	SCF	SCF	NNP
cord-296347-fanlvxqs	199	3	b	b	NN
cord-296347-fanlvxqs	199	4	-	-	:
cord-296347-fanlvxqs	199	5	TrCP	trcp	NN
cord-296347-fanlvxqs	199	6	substrate	substrate	NN
cord-296347-fanlvxqs	199	7	adaptor	adaptor	NN
cord-296347-fanlvxqs	199	8	component	component	NN
cord-296347-fanlvxqs	199	9	is	be	VBZ
cord-296347-fanlvxqs	199	10	the	the	DT
cord-296347-fanlvxqs	199	11	F	F	NNP
cord-296347-fanlvxqs	199	12	-	-	HYPH
cord-296347-fanlvxqs	199	13	box	box	NNP
cord-296347-fanlvxqs	199	14	protein	protein	NN
cord-296347-fanlvxqs	199	15	b	b	NNP
cord-296347-fanlvxqs	199	16	-	-	HYPH
cord-296347-fanlvxqs	199	17	transducin	transducin	NNP
cord-296347-fanlvxqs	199	18	repeat	repeat	NN
cord-296347-fanlvxqs	199	19	-	-	HYPH
cord-296347-fanlvxqs	199	20	containing	contain	VBG
cord-296347-fanlvxqs	199	21	protein	protein	NN
cord-296347-fanlvxqs	199	22	(	(	-LRB-
cord-296347-fanlvxqs	199	23	b	b	NN
cord-296347-fanlvxqs	199	24	-	-	:
cord-296347-fanlvxqs	199	25	TrCP	TrCP	NNP
cord-296347-fanlvxqs	199	26	)	)	-RRB-
cord-296347-fanlvxqs	199	27	that	that	WDT
cord-296347-fanlvxqs	199	28	possesses	possess	VBZ
cord-296347-fanlvxqs	199	29	WD	WD	NNP
cord-296347-fanlvxqs	199	30	repeats	repeat	VBZ
cord-296347-fanlvxqs	199	31	that	that	IN
cord-296347-fanlvxqs	199	32	bind	bind	VBP
cord-296347-fanlvxqs	199	33	to	to	IN
cord-296347-fanlvxqs	199	34	phosphorylated	phosphorylated	JJ
cord-296347-fanlvxqs	199	35	inhibitor	inhibitor	NN
cord-296347-fanlvxqs	199	36	of	of	IN
cord-296347-fanlvxqs	199	37	NF	NF	NNP
cord-296347-fanlvxqs	199	38	-	-	HYPH
cord-296347-fanlvxqs	199	39	kB	kB	NNP
cord-296347-fanlvxqs	199	40	(	(	-LRB-
cord-296347-fanlvxqs	199	41	IkB	IkB	NNP
cord-296347-fanlvxqs	199	42	)	)	-RRB-
cord-296347-fanlvxqs	199	43	,	,	,
cord-296347-fanlvxqs	199	44	inducing	induce	VBG
cord-296347-fanlvxqs	199	45	its	-PRON-	PRP$
cord-296347-fanlvxqs	199	46	ubiquitination	ubiquitination	NN
cord-296347-fanlvxqs	199	47	and	and	CC
cord-296347-fanlvxqs	199	48	degradation	degradation	NN
cord-296347-fanlvxqs	199	49	.	.	.
cord-296347-fanlvxqs	200	1	NF	NF	NNP
cord-296347-fanlvxqs	200	2	-	-	HYPH
cord-296347-fanlvxqs	200	3	kB	kB	NNP
cord-296347-fanlvxqs	200	4	is	be	VBZ
cord-296347-fanlvxqs	200	5	thus	thus	RB
cord-296347-fanlvxqs	200	6	released	release	VBN
cord-296347-fanlvxqs	200	7	from	from	IN
cord-296347-fanlvxqs	200	8	the	the	DT
cord-296347-fanlvxqs	200	9	IkB	ikb	NN
cord-296347-fanlvxqs	200	10	-	-	HYPH
cord-296347-fanlvxqs	200	11	NF	NF	NNP
cord-296347-fanlvxqs	200	12	-	-	HYPH
cord-296347-fanlvxqs	200	13	kB	kB	NNP
cord-296347-fanlvxqs	200	14	dimer	dimer	NN
cord-296347-fanlvxqs	200	15	and	and	CC
cord-296347-fanlvxqs	200	16	translocates	translocates	NNPS
cord-296347-fanlvxqs	200	17	into	into	IN
cord-296347-fanlvxqs	200	18	the	the	DT
cord-296347-fanlvxqs	200	19	nucleus	nucleus	NN
cord-296347-fanlvxqs	200	20	,	,	,
cord-296347-fanlvxqs	200	21	activating	activate	VBG
cord-296347-fanlvxqs	200	22	downstream	downstream	JJ
cord-296347-fanlvxqs	200	23	transcription	transcription	NN
cord-296347-fanlvxqs	200	24	.	.	.
cord-296347-fanlvxqs	201	1	The	the	DT
cord-296347-fanlvxqs	201	2	elongin	elongin	NNP
cord-296347-fanlvxqs	201	3	-	-	HYPH
cord-296347-fanlvxqs	201	4	C	C	NNP
cord-296347-fanlvxqs	201	5	-	-	HYPH
cord-296347-fanlvxqs	201	6	elongin	elongin	NN
cord-296347-fanlvxqs	201	7	-	-	HYPH
cord-296347-fanlvxqs	201	8	B	b	NN
cord-296347-fanlvxqs	201	9	-	-	HYPH
cord-296347-fanlvxqs	201	10	Cullin-5-SOCS	Cullin-5-SOCS	NNP
cord-296347-fanlvxqs	201	11	(	(	-LRB-
cord-296347-fanlvxqs	201	12	ECS	ECS	NNP
cord-296347-fanlvxqs	201	13	)	)	-RRB-
cord-296347-fanlvxqs	201	14	complex	complex	NN
cord-296347-fanlvxqs	201	15	uses	use	VBZ
cord-296347-fanlvxqs	201	16	SOCS	SOCS	NNP
cord-296347-fanlvxqs	201	17	proteins	protein	NNS
cord-296347-fanlvxqs	201	18	as	as	IN
cord-296347-fanlvxqs	201	19	the	the	DT
cord-296347-fanlvxqs	201	20	substrate	substrate	NN
cord-296347-fanlvxqs	201	21	adaptors	adaptor	NNS
cord-296347-fanlvxqs	201	22	.	.	.
cord-296347-fanlvxqs	202	1	SOCS	SOCS	NNP
cord-296347-fanlvxqs	202	2	boxes	box	NNS
cord-296347-fanlvxqs	202	3	bind	bind	VBP
cord-296347-fanlvxqs	202	4	Janus	Janus	NNP
cord-296347-fanlvxqs	202	5	kinases	kinase	NNS
cord-296347-fanlvxqs	202	6	(	(	-LRB-
cord-296347-fanlvxqs	202	7	JAKs	JAKs	NNP
cord-296347-fanlvxqs	202	8	)	)	-RRB-
cord-296347-fanlvxqs	202	9	,	,	,
cord-296347-fanlvxqs	202	10	which	which	WDT
cord-296347-fanlvxqs	202	11	are	be	VBP
cord-296347-fanlvxqs	202	12	recruited	recruit	VBN
cord-296347-fanlvxqs	202	13	and	and	CC
cord-296347-fanlvxqs	202	14	activated	activate	VBN
cord-296347-fanlvxqs	202	15	in	in	IN
cord-296347-fanlvxqs	202	16	response	response	NN
cord-296347-fanlvxqs	202	17	to	to	IN
cord-296347-fanlvxqs	202	18	IFN	IFN	NNP
cord-296347-fanlvxqs	202	19	and	and	CC
cord-296347-fanlvxqs	202	20	cytokine	cytokine	NN
cord-296347-fanlvxqs	202	21	signaling	signaling	NN
cord-296347-fanlvxqs	202	22	,	,	,
cord-296347-fanlvxqs	202	23	promoting	promote	VBG
cord-296347-fanlvxqs	202	24	ubiquitination	ubiquitination	NN
cord-296347-fanlvxqs	202	25	and	and	CC
cord-296347-fanlvxqs	202	26	degradation	degradation	NN
cord-296347-fanlvxqs	202	27	of	of	IN
cord-296347-fanlvxqs	202	28	JAKs	jak	NNS
cord-296347-fanlvxqs	202	29	by	by	IN
cord-296347-fanlvxqs	202	30	the	the	DT
cord-296347-fanlvxqs	202	31	ECS	ECS	NNP
cord-296347-fanlvxqs	202	32	complex	complex	NN
cord-296347-fanlvxqs	202	33	.	.	.
cord-296347-fanlvxqs	203	1	This	this	DT
cord-296347-fanlvxqs	203	2	,	,	,
cord-296347-fanlvxqs	203	3	in	in	IN
cord-296347-fanlvxqs	203	4	turn	turn	NN
cord-296347-fanlvxqs	203	5	,	,	,
cord-296347-fanlvxqs	203	6	inhibits	inhibit	VBZ
cord-296347-fanlvxqs	203	7	phosphorylation	phosphorylation	NN
cord-296347-fanlvxqs	203	8	and	and	CC
cord-296347-fanlvxqs	203	9	activation	activation	NN
cord-296347-fanlvxqs	203	10	of	of	IN
cord-296347-fanlvxqs	203	11	the	the	DT
cord-296347-fanlvxqs	203	12	signal	signal	NN
cord-296347-fanlvxqs	203	13	transducer	transducer	NN
cord-296347-fanlvxqs	203	14	and	and	CC
cord-296347-fanlvxqs	203	15	activator	activator	NN
cord-296347-fanlvxqs	203	16	of	of	IN
cord-296347-fanlvxqs	203	17	transcription	transcription	NN
cord-296347-fanlvxqs	203	18	(	(	-LRB-
cord-296347-fanlvxqs	203	19	STAT	stat	NN
cord-296347-fanlvxqs	203	20	)	)	-RRB-
cord-296347-fanlvxqs	203	21	family	family	NN
cord-296347-fanlvxqs	203	22	of	of	IN
cord-296347-fanlvxqs	203	23	transcription	transcription	NN
cord-296347-fanlvxqs	203	24	factors	factor	NNS
cord-296347-fanlvxqs	203	25	that	that	WDT
cord-296347-fanlvxqs	203	26	are	be	VBP
cord-296347-fanlvxqs	203	27	crucial	crucial	JJ
cord-296347-fanlvxqs	203	28	for	for	IN
cord-296347-fanlvxqs	203	29	the	the	DT
cord-296347-fanlvxqs	203	30	immune	immune	JJ
cord-296347-fanlvxqs	203	31	response	response	NN
cord-296347-fanlvxqs	203	32	following	follow	VBG
cord-296347-fanlvxqs	203	33	IFN	IFN	NNP
cord-296347-fanlvxqs	203	34	and	and	CC
cord-296347-fanlvxqs	203	35	cytokine	cytokine	NN
cord-296347-fanlvxqs	203	36	signaling	signaling	NN
cord-296347-fanlvxqs	203	37	and	and	CC
cord-296347-fanlvxqs	203	38	following	follow	VBG
cord-296347-fanlvxqs	203	39	viral	viral	JJ
cord-296347-fanlvxqs	203	40	infections	infection	NNS
cord-296347-fanlvxqs	203	41	.	.	.
cord-296347-fanlvxqs	204	1	There	there	EX
cord-296347-fanlvxqs	204	2	are	be	VBP
cord-296347-fanlvxqs	204	3	other	other	JJ
cord-296347-fanlvxqs	204	4	families	family	NNS
cord-296347-fanlvxqs	204	5	of	of	IN
cord-296347-fanlvxqs	204	6	E3s	e3s	NN
cord-296347-fanlvxqs	204	7	with	with	IN
cord-296347-fanlvxqs	204	8	noncanonical	noncanonical	JJ
cord-296347-fanlvxqs	204	9	RING	ring	NN
cord-296347-fanlvxqs	204	10	-	-	HYPH
cord-296347-fanlvxqs	204	11	domains	domain	NNS
cord-296347-fanlvxqs	204	12	,	,	,
cord-296347-fanlvxqs	204	13	like	like	IN
cord-296347-fanlvxqs	204	14	the	the	DT
cord-296347-fanlvxqs	204	15	K3	K3	NNP
cord-296347-fanlvxqs	204	16	homologues	homologue	NNS
cord-296347-fanlvxqs	204	17	and	and	CC
cord-296347-fanlvxqs	204	18	the	the	DT
cord-296347-fanlvxqs	204	19	Ufd2homologous	ufd2homologous	JJ
cord-296347-fanlvxqs	204	20	box	box	NN
cord-296347-fanlvxqs	204	21	(	(	-LRB-
cord-296347-fanlvxqs	204	22	U	U	NNP
cord-296347-fanlvxqs	204	23	-	-	HYPH
cord-296347-fanlvxqs	204	24	box	box	NN
cord-296347-fanlvxqs	204	25	)	)	-RRB-
cord-296347-fanlvxqs	204	26	E3s	e3s	NN
cord-296347-fanlvxqs	204	27	(	(	-LRB-
cord-296347-fanlvxqs	204	28	which	which	WDT
cord-296347-fanlvxqs	204	29	we	-PRON-	PRP
cord-296347-fanlvxqs	204	30	discuss	discuss	VBP
cord-296347-fanlvxqs	204	31	in	in	IN
cord-296347-fanlvxqs	204	32	more	more	JJR
cord-296347-fanlvxqs	204	33	detail	detail	NN
cord-296347-fanlvxqs	204	34	later	later	RB
cord-296347-fanlvxqs	204	35	)	)	-RRB-
cord-296347-fanlvxqs	204	36	.	.	.
cord-296347-fanlvxqs	205	1	For	for	IN
cord-296347-fanlvxqs	205	2	a	a	DT
cord-296347-fanlvxqs	205	3	more	more	RBR
cord-296347-fanlvxqs	205	4	comprehensive	comprehensive	JJ
cord-296347-fanlvxqs	205	5	review	review	NN
cord-296347-fanlvxqs	205	6	of	of	IN
cord-296347-fanlvxqs	205	7	HECT	HECT	NNP
cord-296347-fanlvxqs	205	8	and	and	CC
cord-296347-fanlvxqs	205	9	RING	ring	NN
cord-296347-fanlvxqs	205	10	E3s	e3s	NN
cord-296347-fanlvxqs	205	11	and	and	CC
cord-296347-fanlvxqs	205	12	different	different	JJ
cord-296347-fanlvxqs	205	13	classifications	classification	NNS
cord-296347-fanlvxqs	205	14	read	read	VBP
cord-296347-fanlvxqs	205	15	(	(	-LRB-
cord-296347-fanlvxqs	205	16	Ardley	Ardley	NNP
cord-296347-fanlvxqs	205	17	and	and	CC
cord-296347-fanlvxqs	205	18	Robinson	Robinson	NNP
cord-296347-fanlvxqs	205	19	,	,	,
cord-296347-fanlvxqs	205	20	2005	2005	CD
cord-296347-fanlvxqs	205	21	;	;	:
cord-296347-fanlvxqs	205	22	Coscoy	Coscoy	NNP
cord-296347-fanlvxqs	205	23	and	and	CC
cord-296347-fanlvxqs	205	24	Ganem	Ganem	NNP
cord-296347-fanlvxqs	205	25	,	,	,
cord-296347-fanlvxqs	205	26	2003	2003	CD
cord-296347-fanlvxqs	205	27	;	;	:
cord-296347-fanlvxqs	205	28	Hatakeyama	Hatakeyama	NNP
cord-296347-fanlvxqs	205	29	et	et	NNP
cord-296347-fanlvxqs	205	30	al	al	NNP
cord-296347-fanlvxqs	205	31	.	.	NNP
cord-296347-fanlvxqs	205	32	,	,	,
cord-296347-fanlvxqs	205	33	2001	2001	CD
cord-296347-fanlvxqs	205	34	;	;	:
cord-296347-fanlvxqs	205	35	Petroski	Petroski	NNP
cord-296347-fanlvxqs	205	36	and	and	CC
cord-296347-fanlvxqs	205	37	Deshaies	Deshaies	NNP
cord-296347-fanlvxqs	205	38	,	,	,
cord-296347-fanlvxqs	205	39	2005	2005	CD
cord-296347-fanlvxqs	205	40	;	;	:
cord-296347-fanlvxqs	205	41	Sharrocks	Sharrocks	NNP
cord-296347-fanlvxqs	205	42	,	,	,
cord-296347-fanlvxqs	205	43	2006	2006	CD
cord-296347-fanlvxqs	205	44	)	)	-RRB-
cord-296347-fanlvxqs	205	45	.	.	.
cord-296347-fanlvxqs	206	1	Originally	originally	RB
cord-296347-fanlvxqs	206	2	believed	believe	VBN
cord-296347-fanlvxqs	206	3	to	to	TO
cord-296347-fanlvxqs	206	4	always	always	RB
cord-296347-fanlvxqs	206	5	deliver	deliver	VB
cord-296347-fanlvxqs	206	6	a	a	DT
cord-296347-fanlvxqs	206	7	'	'	''
cord-296347-fanlvxqs	206	8	'	'	''
cord-296347-fanlvxqs	206	9	kiss	kiss	NN
cord-296347-fanlvxqs	206	10	of	of	IN
cord-296347-fanlvxqs	206	11	death	death	NN
cord-296347-fanlvxqs	206	12	'	'	''
cord-296347-fanlvxqs	206	13	'	'	''
cord-296347-fanlvxqs	206	14	and	and	CC
cord-296347-fanlvxqs	206	15	target	target	VB
cord-296347-fanlvxqs	206	16	the	the	DT
cord-296347-fanlvxqs	206	17	substrate	substrate	NN
cord-296347-fanlvxqs	206	18	for	for	IN
cord-296347-fanlvxqs	206	19	proteasomal	proteasomal	JJ
cord-296347-fanlvxqs	206	20	degradation	degradation	NN
cord-296347-fanlvxqs	206	21	,	,	,
cord-296347-fanlvxqs	206	22	the	the	DT
cord-296347-fanlvxqs	206	23	much	much	RB
cord-296347-fanlvxqs	206	24	more	more	RBR
cord-296347-fanlvxqs	206	25	wide	wide	RB
cord-296347-fanlvxqs	206	26	-	-	HYPH
cord-296347-fanlvxqs	206	27	ranging	range	VBG
cord-296347-fanlvxqs	206	28	effects	effect	NNS
cord-296347-fanlvxqs	206	29	of	of	IN
cord-296347-fanlvxqs	206	30	Ub	ub	JJ
cord-296347-fanlvxqs	206	31	conjugation	conjugation	NN
cord-296347-fanlvxqs	206	32	are	be	VBP
cord-296347-fanlvxqs	206	33	beginning	begin	VBG
cord-296347-fanlvxqs	206	34	to	to	TO
cord-296347-fanlvxqs	206	35	be	be	VB
cord-296347-fanlvxqs	206	36	appreciated	appreciate	VBN
cord-296347-fanlvxqs	206	37	.	.	.
cord-296347-fanlvxqs	207	1	Chain	chain	NN
cord-296347-fanlvxqs	207	2	length	length	NN
cord-296347-fanlvxqs	207	3	and	and	CC
cord-296347-fanlvxqs	207	4	linkage	linkage	NN
cord-296347-fanlvxqs	207	5	type	type	NN
cord-296347-fanlvxqs	207	6	also	also	RB
cord-296347-fanlvxqs	207	7	influence	influence	VBP
cord-296347-fanlvxqs	207	8	the	the	DT
cord-296347-fanlvxqs	207	9	outcome	outcome	NN
cord-296347-fanlvxqs	207	10	of	of	IN
cord-296347-fanlvxqs	207	11	the	the	DT
cord-296347-fanlvxqs	207	12	Ub	Ub	NNP
cord-296347-fanlvxqs	207	13	-	-	HYPH
cord-296347-fanlvxqs	207	14	conjugated	conjugate	VBN
cord-296347-fanlvxqs	207	15	substrate	substrate	NN
cord-296347-fanlvxqs	207	16	.	.	.
cord-296347-fanlvxqs	208	1	The	the	DT
cord-296347-fanlvxqs	208	2	multiple	multiple	JJ
cord-296347-fanlvxqs	208	3	Ub	Ub	NNP
cord-296347-fanlvxqs	208	4	moieties	moiety	NNS
cord-296347-fanlvxqs	208	5	in	in	IN
cord-296347-fanlvxqs	208	6	a	a	DT
cord-296347-fanlvxqs	208	7	polyUb	polyub	NN
cord-296347-fanlvxqs	208	8	chain	chain	NN
cord-296347-fanlvxqs	208	9	(	(	-LRB-
cord-296347-fanlvxqs	208	10	chains	chain	NNS
cord-296347-fanlvxqs	208	11	of	of	IN
cord-296347-fanlvxqs	208	12	4	4	CD
cord-296347-fanlvxqs	208	13	or	or	CC
cord-296347-fanlvxqs	208	14	more	more	JJR
cord-296347-fanlvxqs	208	15	Ub	ub	JJ
cord-296347-fanlvxqs	208	16	moieties	moiety	NNS
cord-296347-fanlvxqs	208	17	)	)	-RRB-
cord-296347-fanlvxqs	208	18	are	be	VBP
cord-296347-fanlvxqs	208	19	linked	link	VBN
cord-296347-fanlvxqs	208	20	to	to	IN
cord-296347-fanlvxqs	208	21	one	one	CD
cord-296347-fanlvxqs	208	22	another	another	DT
cord-296347-fanlvxqs	208	23	by	by	IN
cord-296347-fanlvxqs	208	24	an	an	DT
cord-296347-fanlvxqs	208	25	isopeptide	isopeptide	NN
cord-296347-fanlvxqs	208	26	bond	bond	NN
cord-296347-fanlvxqs	208	27	between	between	IN
cord-296347-fanlvxqs	208	28	a	a	DT
cord-296347-fanlvxqs	208	29	lysine	lysine	NN
cord-296347-fanlvxqs	208	30	residue	residue	NN
cord-296347-fanlvxqs	208	31	on	on	IN
cord-296347-fanlvxqs	208	32	one	one	CD
cord-296347-fanlvxqs	208	33	Ub	Ub	NNP
cord-296347-fanlvxqs	208	34	molecule	molecule	NN
cord-296347-fanlvxqs	208	35	(	(	-LRB-
cord-296347-fanlvxqs	208	36	usually	usually	RB
cord-296347-fanlvxqs	208	37	on	on	IN
cord-296347-fanlvxqs	208	38	Lys48	Lys48	NNP
cord-296347-fanlvxqs	208	39	)	)	-RRB-
cord-296347-fanlvxqs	208	40	and	and	CC
cord-296347-fanlvxqs	208	41	the	the	DT
cord-296347-fanlvxqs	208	42	C	C	NNP
cord-296347-fanlvxqs	208	43	-	-	HYPH
cord-296347-fanlvxqs	208	44	terminal	terminal	NN
cord-296347-fanlvxqs	208	45	carboxyl	carboxyl	NN
cord-296347-fanlvxqs	208	46	group	group	NN
cord-296347-fanlvxqs	208	47	of	of	IN
cord-296347-fanlvxqs	208	48	the	the	DT
cord-296347-fanlvxqs	208	49	next	next	JJ
cord-296347-fanlvxqs	208	50	Ub	Ub	NNP
cord-296347-fanlvxqs	208	51	on	on	IN
cord-296347-fanlvxqs	208	52	the	the	DT
cord-296347-fanlvxqs	208	53	chain	chain	NN
cord-296347-fanlvxqs	208	54	.	.	.
cord-296347-fanlvxqs	209	1	At	at	IN
cord-296347-fanlvxqs	209	2	times	time	NNS
cord-296347-fanlvxqs	209	3	,	,	,
cord-296347-fanlvxqs	209	4	extension	extension	NN
cord-296347-fanlvxqs	209	5	of	of	IN
cord-296347-fanlvxqs	209	6	a	a	DT
cord-296347-fanlvxqs	209	7	polyUb	polyub	NN
cord-296347-fanlvxqs	209	8	chain	chain	NN
cord-296347-fanlvxqs	209	9	on	on	IN
cord-296347-fanlvxqs	209	10	a	a	DT
cord-296347-fanlvxqs	209	11	substrate	substrate	NN
cord-296347-fanlvxqs	209	12	conjugated	conjugate	VBN
cord-296347-fanlvxqs	209	13	with	with	IN
cord-296347-fanlvxqs	209	14	1	1	CD
cord-296347-fanlvxqs	209	15	-	-	SYM
cord-296347-fanlvxqs	209	16	3	3	CD
cord-296347-fanlvxqs	209	17	'	'	''
cord-296347-fanlvxqs	209	18	'	'	``
cord-296347-fanlvxqs	209	19	initiator	initiator	NN
cord-296347-fanlvxqs	209	20	'	'	''
cord-296347-fanlvxqs	209	21	'	'	''
cord-296347-fanlvxqs	209	22	Ub	Ub	NNP
cord-296347-fanlvxqs	209	23	moieties	moiety	NNS
cord-296347-fanlvxqs	209	24	requires	require	VBZ
cord-296347-fanlvxqs	209	25	a	a	DT
cord-296347-fanlvxqs	209	26	special	special	JJ
cord-296347-fanlvxqs	209	27	subclass	subclass	NN
cord-296347-fanlvxqs	209	28	of	of	IN
cord-296347-fanlvxqs	209	29	E3s	e3s	NN
cord-296347-fanlvxqs	209	30	,	,	,
cord-296347-fanlvxqs	210	1	the	the	DT
cord-296347-fanlvxqs	210	2	UFD2-homology	UFD2-homology	NNP
cord-296347-fanlvxqs	210	3	box	box	NN
cord-296347-fanlvxqs	210	4	(	(	-LRB-
cord-296347-fanlvxqs	210	5	U	U	NNP
cord-296347-fanlvxqs	210	6	-	-	HYPH
cord-296347-fanlvxqs	210	7	box	box	NN
cord-296347-fanlvxqs	210	8	)	)	-RRB-
cord-296347-fanlvxqs	210	9	E3s	e3s	NN
cord-296347-fanlvxqs	210	10	(	(	-LRB-
cord-296347-fanlvxqs	210	11	once	once	RB
cord-296347-fanlvxqs	210	12	called	call	VBN
cord-296347-fanlvxqs	210	13	E4s	e4s	NN
cord-296347-fanlvxqs	210	14	)	)	-RRB-
cord-296347-fanlvxqs	210	15	(	(	-LRB-
cord-296347-fanlvxqs	210	16	Hoppe	Hoppe	NNP
cord-296347-fanlvxqs	210	17	,	,	,
cord-296347-fanlvxqs	210	18	2005	2005	CD
cord-296347-fanlvxqs	210	19	)	)	-RRB-
cord-296347-fanlvxqs	210	20	.	.	.
cord-296347-fanlvxqs	211	1	Targeting	target	VBG
cord-296347-fanlvxqs	211	2	of	of	IN
cord-296347-fanlvxqs	211	3	proteins	protein	NNS
cord-296347-fanlvxqs	211	4	for	for	IN
cord-296347-fanlvxqs	211	5	proteasomal	proteasomal	JJ
cord-296347-fanlvxqs	211	6	proteolysis	proteolysis	NN
cord-296347-fanlvxqs	211	7	generally	generally	RB
cord-296347-fanlvxqs	211	8	requires	require	VBZ
cord-296347-fanlvxqs	211	9	polyubiquitination	polyubiquitination	NN
cord-296347-fanlvxqs	211	10	in	in	IN
cord-296347-fanlvxqs	211	11	a	a	DT
cord-296347-fanlvxqs	211	12	lysine	lysine	NN
cord-296347-fanlvxqs	211	13	(	(	-LRB-
cord-296347-fanlvxqs	211	14	Lys	Lys	NNP
cord-296347-fanlvxqs	211	15	)	)	-RRB-
cord-296347-fanlvxqs	211	16	48-type	48-type	CD
cord-296347-fanlvxqs	211	17	linkage	linkage	NN
cord-296347-fanlvxqs	211	18	.	.	.
cord-296347-fanlvxqs	212	1	By	by	IN
cord-296347-fanlvxqs	212	2	contrast	contrast	NN
cord-296347-fanlvxqs	212	3	to	to	IN
cord-296347-fanlvxqs	212	4	polyUb	polyub	NN
cord-296347-fanlvxqs	212	5	,	,	,
cord-296347-fanlvxqs	212	6	substrate	substrate	NN
cord-296347-fanlvxqs	212	7	monoubiquitination	monoubiquitination	NN
cord-296347-fanlvxqs	212	8	or	or	CC
cord-296347-fanlvxqs	212	9	attachment	attachment	NN
cord-296347-fanlvxqs	212	10	of	of	IN
cord-296347-fanlvxqs	212	11	noncanonical	noncanonical	JJ
cord-296347-fanlvxqs	212	12	Ub	Ub	NNP
cord-296347-fanlvxqs	212	13	chains	chain	NNS
cord-296347-fanlvxqs	212	14	-	-	:
cord-296347-fanlvxqs	212	15	Ub	ub	JJ
cord-296347-fanlvxqs	212	16	chains	chain	NNS
cord-296347-fanlvxqs	212	17	with	with	IN
cord-296347-fanlvxqs	212	18	non	non	JJ
cord-296347-fanlvxqs	212	19	-	-	JJ
cord-296347-fanlvxqs	212	20	Lys48	lys48	JJ
cord-296347-fanlvxqs	212	21	linkages	linkage	NNS
cord-296347-fanlvxqs	212	22	such	such	JJ
cord-296347-fanlvxqs	212	23	as	as	IN
cord-296347-fanlvxqs	212	24	Lys63	Lys63	NNP
cord-296347-fanlvxqs	212	25	and	and	CC
cord-296347-fanlvxqs	212	26	Lys29	Lys29	NNP
cord-296347-fanlvxqs	212	27	linkages	linkage	NNS
cord-296347-fanlvxqs	212	28	-	-	:
cord-296347-fanlvxqs	212	29	usually	usually	RB
cord-296347-fanlvxqs	212	30	have	have	VBP
cord-296347-fanlvxqs	212	31	nonproteolytic	nonproteolytic	JJ
cord-296347-fanlvxqs	212	32	functions	function	NNS
cord-296347-fanlvxqs	212	33	in	in	IN
cord-296347-fanlvxqs	212	34	DNA	dna	NN
cord-296347-fanlvxqs	212	35	repair	repair	NN
cord-296347-fanlvxqs	212	36	,	,	,
cord-296347-fanlvxqs	212	37	endocytosis	endocytosis	NN
cord-296347-fanlvxqs	212	38	,	,	,
cord-296347-fanlvxqs	212	39	signal	signal	NN
cord-296347-fanlvxqs	212	40	transduction	transduction	NN
cord-296347-fanlvxqs	212	41	,	,	,
cord-296347-fanlvxqs	212	42	transcriptional	transcriptional	JJ
cord-296347-fanlvxqs	212	43	regulation	regulation	NN
cord-296347-fanlvxqs	212	44	,	,	,
cord-296347-fanlvxqs	212	45	and	and	CC
cord-296347-fanlvxqs	212	46	ribosoma	ribosoma	NNP
cord-296347-fanlvxqs	212	47	l	l	NNP
cord-296347-fanlvxqs	212	48	function	function	NN
cord-296347-fanlvxqs	212	49	(	(	-LRB-
cord-296347-fanlvxqs	212	50	d	d	XX
cord-296347-fanlvxqs	212	51	'	'	``
cord-296347-fanlvxqs	212	52	Azzo	Azzo	NNP
cord-296347-fanlvxqs	212	53	et	et	NNP
cord-296347-fanlvxqs	212	54	al	al	NNP
cord-296347-fanlvxqs	212	55	.	.	NNP
cord-296347-fanlvxqs	212	56	,	,	,
cord-296347-fanlvxqs	212	57	2005	2005	CD
cord-296347-fanlvxqs	212	58	;	;	:
cord-296347-fanlvxqs	212	59	Pic	pic	NN
cord-296347-fanlvxqs	212	60	kart	kart	NN
cord-296347-fanlvxqs	212	61	and	and	CC
cord-296347-fanlvxqs	212	62	Ed	Ed	NNP
cord-296347-fanlvxqs	212	63	dins	dins	NNP
cord-296347-fanlvxqs	212	64	,	,	,
cord-296347-fanlvxqs	212	65	2004	2004	CD
cord-296347-fanlvxqs	212	66	)	)	-RRB-
cord-296347-fanlvxqs	212	67	.	.	.
cord-296347-fanlvxqs	213	1	Monoubiquitination	monoubiquitination	NN
cord-296347-fanlvxqs	213	2	can	can	MD
cord-296347-fanlvxqs	213	3	occur	occur	VB
cord-296347-fanlvxqs	213	4	on	on	IN
cord-296347-fanlvxqs	213	5	a	a	DT
cord-296347-fanlvxqs	213	6	single	single	JJ
cord-296347-fanlvxqs	213	7	lysine	lysine	NN
cord-296347-fanlvxqs	213	8	residue	residue	NN
cord-296347-fanlvxqs	213	9	or	or	CC
cord-296347-fanlvxqs	213	10	on	on	IN
cord-296347-fanlvxqs	213	11	several	several	JJ
cord-296347-fanlvxqs	213	12	lysine	lysine	NN
cord-296347-fanlvxqs	213	13	residues	residue	NNS
cord-296347-fanlvxqs	213	14	in	in	IN
cord-296347-fanlvxqs	213	15	a	a	DT
cord-296347-fanlvxqs	213	16	substrate	substrate	NN
cord-296347-fanlvxqs	213	17	(	(	-LRB-
cord-296347-fanlvxqs	213	18	multiubiquitination	multiubiquitination	NN
cord-296347-fanlvxqs	213	19	)	)	-RRB-
cord-296347-fanlvxqs	213	20	.	.	.
cord-296347-fanlvxqs	214	1	Monoubiquitination	monoubiquitination	NN
cord-296347-fanlvxqs	214	2	is	be	VBZ
cord-296347-fanlvxqs	214	3	extremely	extremely	RB
cord-296347-fanlvxqs	214	4	important	important	JJ
cord-296347-fanlvxqs	214	5	as	as	IN
cord-296347-fanlvxqs	214	6	a	a	DT
cord-296347-fanlvxqs	214	7	sorting	sorting	NN
cord-296347-fanlvxqs	214	8	signal	signal	NN
cord-296347-fanlvxqs	214	9	in	in	IN
cord-296347-fanlvxqs	214	10	the	the	DT
cord-296347-fanlvxqs	214	11	endocytic	endocytic	JJ
cord-296347-fanlvxqs	214	12	pathway	pathway	NN
cord-296347-fanlvxqs	214	13	.	.	.
cord-296347-fanlvxqs	215	1	For	for	IN
cord-296347-fanlvxqs	215	2	example	example	NN
cord-296347-fanlvxqs	215	3	,	,	,
cord-296347-fanlvxqs	215	4	monoUb	monoub	CD
cord-296347-fanlvxqs	215	5	attachment	attachment	NN
cord-296347-fanlvxqs	215	6	is	be	VBZ
cord-296347-fanlvxqs	215	7	sufficient	sufficient	JJ
cord-296347-fanlvxqs	215	8	to	to	TO
cord-296347-fanlvxqs	215	9	induce	induce	VB
cord-296347-fanlvxqs	215	10	endocytosis	endocytosis	NN
cord-296347-fanlvxqs	215	11	of	of	IN
cord-296347-fanlvxqs	215	12	growth	growth	NN
cord-296347-fanlvxqs	215	13	hormone	hormone	NN
cord-296347-fanlvxqs	215	14	receptor	receptor	NN
cord-296347-fanlvxqs	215	15	and	and	CC
cord-296347-fanlvxqs	215	16	sorting	sort	VBG
cord-296347-fanlvxqs	215	17	to	to	IN
cord-296347-fanlvxqs	215	18	the	the	DT
cord-296347-fanlvxqs	215	19	lysosome	lysosome	NN
cord-296347-fanlvxqs	215	20	for	for	IN
cord-296347-fanlvxqs	215	21	degradation	degradation	NN
cord-296347-fanlvxqs	215	22	(	(	-LRB-
cord-296347-fanlvxqs	215	23	Hicke	Hicke	NNP
cord-296347-fanlvxqs	215	24	,	,	,
cord-296347-fanlvxqs	215	25	2001	2001	CD
cord-296347-fanlvxqs	215	26	;	;	:
cord-296347-fanlvxqs	215	27	Hicke	Hicke	NNP
cord-296347-fanlvxqs	215	28	and	and	CC
cord-296347-fanlvxqs	215	29	Dunn	Dunn	NNP
cord-296347-fanlvxqs	215	30	,	,	,
cord-296347-fanlvxqs	215	31	2003	2003	CD
cord-296347-fanlvxqs	215	32	)	)	-RRB-
cord-296347-fanlvxqs	215	33	.	.	.
cord-296347-fanlvxqs	216	1	Direct	direct	JJ
cord-296347-fanlvxqs	216	2	modification	modification	NN
cord-296347-fanlvxqs	216	3	of	of	IN
cord-296347-fanlvxqs	216	4	the	the	DT
cord-296347-fanlvxqs	216	5	cargo	cargo	NN
cord-296347-fanlvxqs	216	6	(	(	-LRB-
cord-296347-fanlvxqs	216	7	cis	cis	NNP
cord-296347-fanlvxqs	216	8	-	-	HYPH
cord-296347-fanlvxqs	216	9	regulation	regulation	NN
cord-296347-fanlvxqs	216	10	)	)	-RRB-
cord-296347-fanlvxqs	216	11	or	or	CC
cord-296347-fanlvxqs	216	12	modification	modification	NN
cord-296347-fanlvxqs	216	13	of	of	IN
cord-296347-fanlvxqs	216	14	the	the	DT
cord-296347-fanlvxqs	216	15	proteintrafficking	proteintrafficking	NN
cord-296347-fanlvxqs	216	16	machinery	machinery	NN
cord-296347-fanlvxqs	216	17	(	(	-LRB-
cord-296347-fanlvxqs	216	18	trans	trans	NNP
cord-296347-fanlvxqs	216	19	-	-	NN
cord-296347-fanlvxqs	216	20	regulation	regulation	NN
cord-296347-fanlvxqs	216	21	)	)	-RRB-
cord-296347-fanlvxqs	216	22	by	by	IN
cord-296347-fanlvxqs	216	23	monoUb	monoub	CD
cord-296347-fanlvxqs	216	24	could	could	MD
cord-296347-fanlvxqs	216	25	have	have	VB
cord-296347-fanlvxqs	216	26	many	many	JJ
cord-296347-fanlvxqs	216	27	consequences	consequence	NNS
cord-296347-fanlvxqs	216	28	for	for	IN
cord-296347-fanlvxqs	216	29	antigen	antigen	NN
cord-296347-fanlvxqs	216	30	presentation	presentation	NN
cord-296347-fanlvxqs	216	31	,	,	,
cord-296347-fanlvxqs	216	32	as	as	IN
cord-296347-fanlvxqs	216	33	these	these	DT
cord-296347-fanlvxqs	216	34	processes	process	NNS
cord-296347-fanlvxqs	216	35	rely	rely	VBP
cord-296347-fanlvxqs	216	36	heavily	heavily	RB
cord-296347-fanlvxqs	216	37	on	on	IN
cord-296347-fanlvxqs	216	38	events	event	NNS
cord-296347-fanlvxqs	216	39	that	that	WDT
cord-296347-fanlvxqs	216	40	take	take	VBP
cord-296347-fanlvxqs	216	41	place	place	NN
cord-296347-fanlvxqs	216	42	in	in	IN
cord-296347-fanlvxqs	216	43	endolysosomal	endolysosomal	JJ
cord-296347-fanlvxqs	216	44	compartments	compartment	NNS
cord-296347-fanlvxqs	216	45	.	.	.
cord-296347-fanlvxqs	217	1	Noncanonical	noncanonical	JJ
cord-296347-fanlvxqs	217	2	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	217	3	chains	chain	NNS
cord-296347-fanlvxqs	217	4	play	play	VBP
cord-296347-fanlvxqs	217	5	many	many	JJ
cord-296347-fanlvxqs	217	6	diverse	diverse	JJ
cord-296347-fanlvxqs	217	7	roles	role	NNS
cord-296347-fanlvxqs	217	8	in	in	IN
cord-296347-fanlvxqs	217	9	signaling	signal	VBG
cord-296347-fanlvxqs	217	10	pathways	pathway	NNS
cord-296347-fanlvxqs	217	11	,	,	,
cord-296347-fanlvxqs	217	12	in	in	IN
cord-296347-fanlvxqs	217	13	DNA	dna	NN
cord-296347-fanlvxqs	217	14	replication	replication	NN
cord-296347-fanlvxqs	217	15	and	and	CC
cord-296347-fanlvxqs	217	16	postreplication	postreplication	NN
cord-296347-fanlvxqs	217	17	DNA	dna	NN
cord-296347-fanlvxqs	217	18	repair	repair	NN
cord-296347-fanlvxqs	217	19	,	,	,
cord-296347-fanlvxqs	217	20	and	and	CC
cord-296347-fanlvxqs	217	21	modulating	modulate	VBG
cord-296347-fanlvxqs	217	22	protein	protein	NN
cord-296347-fanlvxqs	217	23	-	-	HYPH
cord-296347-fanlvxqs	217	24	protein	protein	NN
cord-296347-fanlvxqs	217	25	interactions	interaction	NNS
cord-296347-fanlvxqs	217	26	.	.	.
cord-296347-fanlvxqs	218	1	For	for	IN
cord-296347-fanlvxqs	218	2	instance	instance	NN
cord-296347-fanlvxqs	218	3	,	,	,
cord-296347-fanlvxqs	218	4	activation	activation	NN
cord-296347-fanlvxqs	218	5	of	of	IN
cord-296347-fanlvxqs	218	6	NF	NF	NNP
cord-296347-fanlvxqs	218	7	-	-	HYPH
cord-296347-fanlvxqs	218	8	kB	kB	NNP
cord-296347-fanlvxqs	218	9	is	be	VBZ
cord-296347-fanlvxqs	218	10	tightly	tightly	RB
cord-296347-fanlvxqs	218	11	regulated	regulate	VBN
cord-296347-fanlvxqs	218	12	by	by	IN
cord-296347-fanlvxqs	218	13	a	a	DT
cord-296347-fanlvxqs	218	14	balance	balance	NN
cord-296347-fanlvxqs	218	15	between	between	IN
cord-296347-fanlvxqs	218	16	Lys48-and	lys48-and	NN
cord-296347-fanlvxqs	218	17	Lys63-mediated	lys63-mediate	VBN
cord-296347-fanlvxqs	218	18	ubiquitination	ubiquitination	NN
cord-296347-fanlvxqs	218	19	of	of	IN
cord-296347-fanlvxqs	218	20	different	different	JJ
cord-296347-fanlvxqs	218	21	components	component	NNS
cord-296347-fanlvxqs	218	22	of	of	IN
cord-296347-fanlvxqs	218	23	the	the	DT
cord-296347-fanlvxqs	218	24	NF	NF	NNP
cord-296347-fanlvxqs	218	25	-	-	HYPH
cord-296347-fanlvxqs	218	26	kB	kB	NNP
cord-296347-fanlvxqs	218	27	pathway	pathway	NN
cord-296347-fanlvxqs	218	28	.	.	.
cord-296347-fanlvxqs	219	1	Triggering	trigger	VBG
cord-296347-fanlvxqs	219	2	of	of	IN
cord-296347-fanlvxqs	219	3	many	many	JJ
cord-296347-fanlvxqs	219	4	cell	cell	NN
cord-296347-fanlvxqs	219	5	-	-	HYPH
cord-296347-fanlvxqs	219	6	surface	surface	NN
cord-296347-fanlvxqs	219	7	receptors	receptor	NNS
cord-296347-fanlvxqs	219	8	leads	lead	VBZ
cord-296347-fanlvxqs	219	9	to	to	IN
cord-296347-fanlvxqs	219	10	assembly	assembly	NN
cord-296347-fanlvxqs	219	11	of	of	IN
cord-296347-fanlvxqs	219	12	signaling	signal	VBG
cord-296347-fanlvxqs	219	13	complexes	complex	NNS
cord-296347-fanlvxqs	219	14	that	that	WDT
cord-296347-fanlvxqs	219	15	recruit	recruit	VBP
cord-296347-fanlvxqs	219	16	tumor	tumor	NN
cord-296347-fanlvxqs	219	17	necrosis	necrosis	NN
cord-296347-fanlvxqs	219	18	factor	factor	NN
cord-296347-fanlvxqs	219	19	receptor	receptor	NN
cord-296347-fanlvxqs	219	20	-	-	HYPH
cord-296347-fanlvxqs	219	21	associated	associate	VBN
cord-296347-fanlvxqs	219	22	factor	factor	NN
cord-296347-fanlvxqs	219	23	6	6	CD
cord-296347-fanlvxqs	219	24	(	(	-LRB-
cord-296347-fanlvxqs	219	25	TRAF6	TRAF6	NNP
cord-296347-fanlvxqs	219	26	)	)	-RRB-
cord-296347-fanlvxqs	219	27	,	,	.
cord-296347-fanlvxqs	220	1	an	an	DT
cord-296347-fanlvxqs	220	2	E3	e3	NN
cord-296347-fanlvxqs	220	3	ligase	ligase	NN
cord-296347-fanlvxqs	220	4	that	that	WDT
cord-296347-fanlvxqs	220	5	binds	bind	VBZ
cord-296347-fanlvxqs	220	6	UBC13	UBC13	NNP
cord-296347-fanlvxqs	220	7	,	,	,
cord-296347-fanlvxqs	220	8	promoting	promote	VBG
cord-296347-fanlvxqs	220	9	Lys63-linked	lys63-linked	IN
cord-296347-fanlvxqs	220	10	polyubiquitination	polyubiquitination	NN
cord-296347-fanlvxqs	220	11	of	of	IN
cord-296347-fanlvxqs	220	12	the	the	DT
cord-296347-fanlvxqs	220	13	g	g	NNP
cord-296347-fanlvxqs	220	14	subunit	subunit	NN
cord-296347-fanlvxqs	220	15	of	of	IN
cord-296347-fanlvxqs	220	16	the	the	DT
cord-296347-fanlvxqs	220	17	inhibitor	inhibitor	NN
cord-296347-fanlvxqs	220	18	of	of	IN
cord-296347-fanlvxqs	220	19	NF	NF	NNP
cord-296347-fanlvxqs	220	20	-	-	HYPH
cord-296347-fanlvxqs	220	21	kB	kB	NNP
cord-296347-fanlvxqs	220	22	kinase	kinase	NN
cord-296347-fanlvxqs	220	23	(	(	-LRB-
cord-296347-fanlvxqs	220	24	IKK	IKK	NNP
cord-296347-fanlvxqs	220	25	)	)	-RRB-
cord-296347-fanlvxqs	220	26	complex	complex	NNP
cord-296347-fanlvxqs	220	27	,	,	,
cord-296347-fanlvxqs	220	28	IKKg	IKKg	NNS
cord-296347-fanlvxqs	220	29	.	.	.
cord-296347-fanlvxqs	221	1	This	this	DT
cord-296347-fanlvxqs	221	2	leads	lead	VBZ
cord-296347-fanlvxqs	221	3	to	to	IN
cord-296347-fanlvxqs	221	4	activation	activation	NN
cord-296347-fanlvxqs	221	5	of	of	IN
cord-296347-fanlvxqs	221	6	the	the	DT
cord-296347-fanlvxqs	221	7	IKK	IKK	NNP
cord-296347-fanlvxqs	221	8	complex	complex	NN
cord-296347-fanlvxqs	221	9	,	,	,
cord-296347-fanlvxqs	221	10	which	which	WDT
cord-296347-fanlvxqs	221	11	in	in	IN
cord-296347-fanlvxqs	221	12	turn	turn	NN
cord-296347-fanlvxqs	221	13	results	result	VBZ
cord-296347-fanlvxqs	221	14	in	in	IN
cord-296347-fanlvxqs	221	15	IkB	ikb	NN
cord-296347-fanlvxqs	221	16	phosphorylation	phosphorylation	NN
cord-296347-fanlvxqs	221	17	.	.	.
cord-296347-fanlvxqs	222	1	Phosho	Phosho	NNP
cord-296347-fanlvxqs	222	2	-	-	HYPH
cord-296347-fanlvxqs	222	3	IkB	IkB	NNP
cord-296347-fanlvxqs	222	4	then	then	RB
cord-296347-fanlvxqs	222	5	recruits	recruit	VBZ
cord-296347-fanlvxqs	222	6	the	the	DT
cord-296347-fanlvxqs	222	7	SCF	SCF	NNP
cord-296347-fanlvxqs	222	8	complex	complex	NN
cord-296347-fanlvxqs	222	9	that	that	WDT
cord-296347-fanlvxqs	222	10	catalyzes	catalyze	VBZ
cord-296347-fanlvxqs	222	11	Lys48-linked	lys48-linke	VBN
cord-296347-fanlvxqs	222	12	polyubiquitination	polyubiquitination	NN
cord-296347-fanlvxqs	222	13	of	of	IN
cord-296347-fanlvxqs	222	14	IkB	ikb	NN
cord-296347-fanlvxqs	222	15	and	and	CC
cord-296347-fanlvxqs	222	16	consequently	consequently	RB
cord-296347-fanlvxqs	222	17	activates	activate	VBZ
cord-296347-fanlvxqs	222	18	NF	NF	NNP
cord-296347-fanlvxqs	222	19	-	-	HYPH
cord-296347-fanlvxqs	222	20	kB	kB	NNP
cord-296347-fanlvxqs	223	1	(	(	-LRB-
cord-296347-fanlvxqs	223	2	Karin	Karin	NNP
cord-296347-fanlvxqs	223	3	and	and	CC
cord-296347-fanlvxqs	223	4	Ben	Ben	NNP
cord-296347-fanlvxqs	223	5	-	-	HYPH
cord-296347-fanlvxqs	223	6	Neriah	Neriah	NNP
cord-296347-fanlvxqs	223	7	,	,	,
cord-296347-fanlvxqs	223	8	2000	2000	CD
cord-296347-fanlvxqs	223	9	)	)	-RRB-
cord-296347-fanlvxqs	223	10	.	.	.
cord-296347-fanlvxqs	224	1	For	for	IN
cord-296347-fanlvxqs	224	2	comprehensive	comprehensive	JJ
cord-296347-fanlvxqs	224	3	reviews	review	NNS
cord-296347-fanlvxqs	224	4	see	see	VBP
cord-296347-fanlvxqs	224	5	Pickart	Pickart	NNP
cord-296347-fanlvxqs	224	6	and	and	CC
cord-296347-fanlvxqs	224	7	Eddins	Eddins	NNP
cord-296347-fanlvxqs	224	8	,	,	,
cord-296347-fanlvxqs	224	9	2004	2004	CD
cord-296347-fanlvxqs	224	10	;	;	:
cord-296347-fanlvxqs	224	11	Varshavsky	Varshavsky	NNP
cord-296347-fanlvxqs	224	12	,	,	,
cord-296347-fanlvxqs	224	13	2005	2005	CD
cord-296347-fanlvxqs	224	14	)	)	-RRB-
cord-296347-fanlvxqs	224	15	.	.	.
cord-296347-fanlvxqs	225	1	Ubiquitin	Ubiquitin	NNP
cord-296347-fanlvxqs	225	2	-	-	HYPH
cord-296347-fanlvxqs	225	3	like	like	JJ
cord-296347-fanlvxqs	225	4	molecules	molecule	NNS
cord-296347-fanlvxqs	225	5	or	or	CC
cord-296347-fanlvxqs	225	6	modifiers	modifier	NNS
cord-296347-fanlvxqs	226	1	(	(	-LRB-
cord-296347-fanlvxqs	226	2	Ubls	Ubls	NNP
cord-296347-fanlvxqs	226	3	)	)	-RRB-
cord-296347-fanlvxqs	226	4	share	share	VB
cord-296347-fanlvxqs	226	5	structural	structural	JJ
cord-296347-fanlvxqs	226	6	homology	homology	NN
cord-296347-fanlvxqs	226	7	with	with	IN
cord-296347-fanlvxqs	226	8	Ub	Ub	NNP
cord-296347-fanlvxqs	226	9	and	and	CC
cord-296347-fanlvxqs	226	10	can	can	MD
cord-296347-fanlvxqs	226	11	also	also	RB
cord-296347-fanlvxqs	226	12	be	be	VB
cord-296347-fanlvxqs	226	13	conjugated	conjugate	VBN
cord-296347-fanlvxqs	226	14	onto	onto	IN
cord-296347-fanlvxqs	226	15	protein	protein	NN
cord-296347-fanlvxqs	226	16	substrates	substrate	NNS
cord-296347-fanlvxqs	226	17	,	,	,
cord-296347-fanlvxqs	226	18	mostly	mostly	RB
cord-296347-fanlvxqs	226	19	with	with	IN
cord-296347-fanlvxqs	226	20	outcomes	outcome	NNS
cord-296347-fanlvxqs	226	21	other	other	JJ
cord-296347-fanlvxqs	226	22	than	than	IN
cord-296347-fanlvxqs	226	23	proteasomal	proteasomal	JJ
cord-296347-fanlvxqs	226	24	degradation	degradation	NN
cord-296347-fanlvxqs	226	25	.	.	.
cord-296347-fanlvxqs	227	1	Ubls	Ubls	NNP
cord-296347-fanlvxqs	227	2	like	like	IN
cord-296347-fanlvxqs	227	3	the	the	DT
cord-296347-fanlvxqs	227	4	small	small	JJ
cord-296347-fanlvxqs	227	5	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	227	6	-	-	HYPH
cord-296347-fanlvxqs	227	7	like	like	JJ
cord-296347-fanlvxqs	227	8	modifier	modifier	NN
cord-296347-fanlvxqs	227	9	SUMO	sumo	NN
cord-296347-fanlvxqs	227	10	,	,	,
cord-296347-fanlvxqs	227	11	neuronal	neuronal	JJ
cord-296347-fanlvxqs	227	12	precursor	precursor	NN
cord-296347-fanlvxqs	227	13	cell	cell	NN
cord-296347-fanlvxqs	227	14	-	-	:
cord-296347-fanlvxqs	227	15	expressed	express	VBN
cord-296347-fanlvxqs	227	16	developmentally	developmentally	RB
cord-296347-fanlvxqs	227	17	down	down	RB
cord-296347-fanlvxqs	227	18	-	-	HYPH
cord-296347-fanlvxqs	227	19	regulated	regulate	VBN
cord-296347-fanlvxqs	227	20	8	8	CD
cord-296347-fanlvxqs	227	21	(	(	-LRB-
cord-296347-fanlvxqs	227	22	NEDD8	NEDD8	NNP
cord-296347-fanlvxqs	227	23	)	)	-RRB-
cord-296347-fanlvxqs	227	24	or	or	CC
cord-296347-fanlvxqs	227	25	IFN	IFN	NNP
cord-296347-fanlvxqs	227	26	-	-	HYPH
cord-296347-fanlvxqs	227	27	stimulated	stimulate	VBN
cord-296347-fanlvxqs	227	28	gene	gene	NN
cord-296347-fanlvxqs	227	29	product	product	NN
cord-296347-fanlvxqs	227	30	of	of	IN
cord-296347-fanlvxqs	227	31	15	15	CD
cord-296347-fanlvxqs	227	32	kDa	kDa	NNS
cord-296347-fanlvxqs	227	33	(	(	-LRB-
cord-296347-fanlvxqs	227	34	ISG15	ISG15	NNP
cord-296347-fanlvxqs	227	35	)	)	-RRB-
cord-296347-fanlvxqs	227	36	,	,	,
cord-296347-fanlvxqs	227	37	to	to	TO
cord-296347-fanlvxqs	227	38	name	name	VB
cord-296347-fanlvxqs	228	1	but	but	CC
cord-296347-fanlvxqs	228	2	a	a	DT
cord-296347-fanlvxqs	228	3	few	few	JJ
cord-296347-fanlvxqs	228	4	,	,	,
cord-296347-fanlvxqs	228	5	are	be	VBP
cord-296347-fanlvxqs	228	6	implicated	implicate	VBN
cord-296347-fanlvxqs	228	7	in	in	IN
cord-296347-fanlvxqs	228	8	important	important	JJ
cord-296347-fanlvxqs	228	9	physiological	physiological	JJ
cord-296347-fanlvxqs	228	10	processes	process	NNS
cord-296347-fanlvxqs	228	11	like	like	IN
cord-296347-fanlvxqs	228	12	nuclear	nuclear	JJ
cord-296347-fanlvxqs	228	13	transport	transport	NN
cord-296347-fanlvxqs	228	14	,	,	,
cord-296347-fanlvxqs	228	15	maintenance	maintenance	NN
cord-296347-fanlvxqs	228	16	of	of	IN
cord-296347-fanlvxqs	228	17	chromosome	chromosome	NN
cord-296347-fanlvxqs	228	18	integrity	integrity	NN
cord-296347-fanlvxqs	228	19	,	,	,
cord-296347-fanlvxqs	228	20	transcriptional	transcriptional	JJ
cord-296347-fanlvxqs	228	21	regulation	regulation	NN
cord-296347-fanlvxqs	228	22	,	,	,
cord-296347-fanlvxqs	228	23	cell	cell	NN
cord-296347-fanlvxqs	228	24	cycle	cycle	NN
cord-296347-fanlvxqs	228	25	control	control	NN
cord-296347-fanlvxqs	228	26	,	,	,
cord-296347-fanlvxqs	228	27	signaling	signaling	NN
cord-296347-fanlvxqs	228	28	and	and	CC
cord-296347-fanlvxqs	228	29	regulation	regulation	NN
cord-296347-fanlvxqs	228	30	of	of	IN
cord-296347-fanlvxqs	228	31	proteolysis	proteolysis	NN
cord-296347-fanlvxqs	228	32	(	(	-LRB-
cord-296347-fanlvxqs	228	33	Hochstrasser	Hochstrasser	NNP
cord-296347-fanlvxqs	228	34	,	,	,
cord-296347-fanlvxqs	228	35	2001	2001	CD
cord-296347-fanlvxqs	228	36	;	;	:
cord-296347-fanlvxqs	228	37	Schwartz	Schwartz	NNP
cord-296347-fanlvxqs	228	38	and	and	CC
cord-296347-fanlvxqs	228	39	Hochstrasser	Hochstrasser	NNP
cord-296347-fanlvxqs	228	40	,	,	,
cord-296347-fanlvxqs	228	41	2003	2003	CD
cord-296347-fanlvxqs	228	42	)	)	-RRB-
cord-296347-fanlvxqs	228	43	.	.	.
cord-296347-fanlvxqs	229	1	Ubls	Ubls	NNP
cord-296347-fanlvxqs	229	2	may	may	MD
cord-296347-fanlvxqs	229	3	regulate	regulate	VB
cord-296347-fanlvxqs	229	4	Ub	Ub	NNP
cord-296347-fanlvxqs	229	5	-	-	HYPH
cord-296347-fanlvxqs	229	6	mediated	mediate	VBN
cord-296347-fanlvxqs	229	7	proteolysis	proteolysis	NN
cord-296347-fanlvxqs	229	8	or	or	CC
cord-296347-fanlvxqs	229	9	signaling	signal	VBG
cord-296347-fanlvxqs	229	10	through	through	IN
cord-296347-fanlvxqs	229	11	comodification	comodification	NN
cord-296347-fanlvxqs	229	12	of	of	IN
cord-296347-fanlvxqs	229	13	a	a	DT
cord-296347-fanlvxqs	229	14	substrate	substrate	NN
cord-296347-fanlvxqs	229	15	,	,	,
cord-296347-fanlvxqs	229	16	thus	thus	RB
cord-296347-fanlvxqs	229	17	modulating	modulate	VBG
cord-296347-fanlvxqs	229	18	the	the	DT
cord-296347-fanlvxqs	229	19	effects	effect	NNS
cord-296347-fanlvxqs	229	20	of	of	IN
cord-296347-fanlvxqs	229	21	Ub	ub	JJ
cord-296347-fanlvxqs	229	22	conjugation	conjugation	NN
cord-296347-fanlvxqs	229	23	(	(	-LRB-
cord-296347-fanlvxqs	229	24	Lamsoul	Lamsoul	NNP
cord-296347-fanlvxqs	229	25	et	et	FW
cord-296347-fanlvxqs	229	26	al	al	NNP
cord-296347-fanlvxqs	229	27	.	.	NNP
cord-296347-fanlvxqs	229	28	,	,	,
cord-296347-fanlvxqs	229	29	2005	2005	CD
cord-296347-fanlvxqs	229	30	;	;	:
cord-296347-fanlvxqs	229	31	Sobko	Sobko	NNP
cord-296347-fanlvxqs	229	32	et	et	NNP
cord-296347-fanlvxqs	229	33	al	al	NNP
cord-296347-fanlvxqs	229	34	.	.	NNP
cord-296347-fanlvxqs	229	35	,	,	,
cord-296347-fanlvxqs	229	36	2002	2002	CD
cord-296347-fanlvxqs	229	37	)	)	-RRB-
cord-296347-fanlvxqs	229	38	or	or	CC
cord-296347-fanlvxqs	229	39	by	by	IN
cord-296347-fanlvxqs	229	40	regulating	regulate	VBG
cord-296347-fanlvxqs	229	41	the	the	DT
cord-296347-fanlvxqs	229	42	activity	activity	NN
cord-296347-fanlvxqs	229	43	,	,	,
cord-296347-fanlvxqs	229	44	specificity	specificity	NN
cord-296347-fanlvxqs	229	45	,	,	,
cord-296347-fanlvxqs	229	46	localization	localization	NN
cord-296347-fanlvxqs	229	47	,	,	,
cord-296347-fanlvxqs	229	48	or	or	CC
cord-296347-fanlvxqs	229	49	stability	stability	NN
cord-296347-fanlvxqs	229	50	of	of	IN
cord-296347-fanlvxqs	229	51	enzymes	enzyme	NNS
cord-296347-fanlvxqs	229	52	in	in	IN
cord-296347-fanlvxqs	229	53	the	the	DT
cord-296347-fanlvxqs	229	54	Ub	Ub	NNP
cord-296347-fanlvxqs	229	55	-	-	HYPH
cord-296347-fanlvxqs	229	56	conjugating	conjugate	VBG
cord-296347-fanlvxqs	229	57	cascade	cascade	NN
cord-296347-fanlvxqs	229	58	,	,	,
cord-296347-fanlvxqs	229	59	as	as	IN
cord-296347-fanlvxqs	229	60	is	be	VBZ
cord-296347-fanlvxqs	229	61	the	the	DT
cord-296347-fanlvxqs	229	62	case	case	NN
cord-296347-fanlvxqs	229	63	for	for	IN
cord-296347-fanlvxqs	229	64	NEDD8	NEDD8	NNP
cord-296347-fanlvxqs	229	65	modification	modification	NN
cord-296347-fanlvxqs	229	66	of	of	IN
cord-296347-fanlvxqs	229	67	Cullin	Cullin	NNP
cord-296347-fanlvxqs	229	68	-	-	HYPH
cord-296347-fanlvxqs	229	69	RING	ring	NN
cord-296347-fanlvxqs	229	70	E3s	e3s	NN
cord-296347-fanlvxqs	230	1	(	(	-LRB-
cord-296347-fanlvxqs	230	2	Kawakami	Kawakami	NNP
cord-296347-fanlvxqs	230	3	et	et	NNP
cord-296347-fanlvxqs	230	4	al	al	NNP
cord-296347-fanlvxqs	230	5	.	.	NNP
cord-296347-fanlvxqs	230	6	,	,	,
cord-296347-fanlvxqs	230	7	2001	2001	CD
cord-296347-fanlvxqs	230	8	;	;	:
cord-296347-fanlvxqs	230	9	Petroski	Petroski	NNP
cord-296347-fanlvxqs	230	10	and	and	CC
cord-296347-fanlvxqs	230	11	Deshaies	Deshaies	NNP
cord-296347-fanlvxqs	230	12	,	,	,
cord-296347-fanlvxqs	230	13	2005	2005	CD
cord-296347-fanlvxqs	230	14	;	;	:
cord-296347-fanlvxqs	230	15	Wu	Wu	NNP
cord-296347-fanlvxqs	230	16	et	et	NNP
cord-296347-fanlvxqs	230	17	al	al	NNP
cord-296347-fanlvxqs	230	18	.	.	NNP
cord-296347-fanlvxqs	230	19	,	,	,
cord-296347-fanlvxqs	230	20	2005	2005	CD
cord-296347-fanlvxqs	230	21	)	)	-RRB-
cord-296347-fanlvxqs	230	22	.	.	.
cord-296347-fanlvxqs	231	1	Deubiquitinating	deubiquitinating	NN
cord-296347-fanlvxqs	231	2	enzymes	enzyme	NNS
cord-296347-fanlvxqs	231	3	can	can	MD
cord-296347-fanlvxqs	231	4	cleave	cleave	VB
cord-296347-fanlvxqs	231	5	isopeptide	isopeptide	NN
cord-296347-fanlvxqs	231	6	bonds	bond	NNS
cord-296347-fanlvxqs	231	7	to	to	TO
cord-296347-fanlvxqs	231	8	remove	remove	VB
cord-296347-fanlvxqs	231	9	Ub	Ub	NNP
cord-296347-fanlvxqs	231	10	from	from	IN
cord-296347-fanlvxqs	231	11	the	the	DT
cord-296347-fanlvxqs	231	12	substrate	substrate	NN
cord-296347-fanlvxqs	231	13	or	or	CC
cord-296347-fanlvxqs	231	14	from	from	IN
cord-296347-fanlvxqs	231	15	polyubiquitin	polyubiquitin	NNP
cord-296347-fanlvxqs	231	16	chains	chain	NNS
cord-296347-fanlvxqs	231	17	.	.	.
cord-296347-fanlvxqs	232	1	There	there	EX
cord-296347-fanlvxqs	232	2	are	be	VBP
cord-296347-fanlvxqs	232	3	about	about	RB
cord-296347-fanlvxqs	232	4	100	100	CD
cord-296347-fanlvxqs	232	5	DUBs	dub	NNS
cord-296347-fanlvxqs	232	6	in	in	IN
cord-296347-fanlvxqs	232	7	the	the	DT
cord-296347-fanlvxqs	232	8	human	human	JJ
cord-296347-fanlvxqs	232	9	genome	genome	NN
cord-296347-fanlvxqs	232	10	,	,	,
cord-296347-fanlvxqs	232	11	organized	organize	VBN
cord-296347-fanlvxqs	232	12	in	in	IN
cord-296347-fanlvxqs	232	13	five	five	CD
cord-296347-fanlvxqs	232	14	classes	class	NNS
cord-296347-fanlvxqs	232	15	according	accord	VBG
cord-296347-fanlvxqs	232	16	to	to	IN
cord-296347-fanlvxqs	232	17	their	-PRON-	PRP$
cord-296347-fanlvxqs	232	18	catalytic	catalytic	JJ
cord-296347-fanlvxqs	232	19	domain	domain	NN
cord-296347-fanlvxqs	232	20	structure	structure	NN
cord-296347-fanlvxqs	232	21	:	:	:
cord-296347-fanlvxqs	232	22	the	the	DT
cord-296347-fanlvxqs	232	23	ubiquitin	ubiquitin	RB
cord-296347-fanlvxqs	232	24	-	-	HYPH
cord-296347-fanlvxqs	232	25	specific	specific	JJ
cord-296347-fanlvxqs	232	26	proteases	protease	NNS
cord-296347-fanlvxqs	232	27	(	(	-LRB-
cord-296347-fanlvxqs	232	28	USPs	USPs	NNP
cord-296347-fanlvxqs	232	29	)	)	-RRB-
cord-296347-fanlvxqs	232	30	,	,	,
cord-296347-fanlvxqs	232	31	the	the	DT
cord-296347-fanlvxqs	232	32	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	232	33	C	c	NN
cord-296347-fanlvxqs	232	34	-	-	HYPH
cord-296347-fanlvxqs	232	35	terminal	terminal	NN
cord-296347-fanlvxqs	232	36	hydrolases	hydrolase	NNS
cord-296347-fanlvxqs	232	37	(	(	-LRB-
cord-296347-fanlvxqs	232	38	UCHs	UCHs	NNP
cord-296347-fanlvxqs	232	39	)	)	-RRB-
cord-296347-fanlvxqs	232	40	,	,	,
cord-296347-fanlvxqs	232	41	the	the	DT
cord-296347-fanlvxqs	232	42	Machado	Machado	NNP
cord-296347-fanlvxqs	232	43	-	-	HYPH
cord-296347-fanlvxqs	232	44	Joseph	Joseph	NNP
cord-296347-fanlvxqs	232	45	disease	disease	NN
cord-296347-fanlvxqs	232	46	proteases	protease	NNS
cord-296347-fanlvxqs	232	47	(	(	-LRB-
cord-296347-fanlvxqs	232	48	MJDs	MJDs	NNP
cord-296347-fanlvxqs	232	49	)	)	-RRB-
cord-296347-fanlvxqs	232	50	,	,	,
cord-296347-fanlvxqs	232	51	the	the	DT
cord-296347-fanlvxqs	232	52	ovarian	ovarian	JJ
cord-296347-fanlvxqs	232	53	tumor	tumor	NN
cord-296347-fanlvxqs	232	54	proteases	protease	NNS
cord-296347-fanlvxqs	232	55	(	(	-LRB-
cord-296347-fanlvxqs	232	56	OTUs	OTUs	NNPS
cord-296347-fanlvxqs	232	57	)	)	-RRB-
cord-296347-fanlvxqs	232	58	,	,	,
cord-296347-fanlvxqs	232	59	and	and	CC
cord-296347-fanlvxqs	232	60	the	the	DT
cord-296347-fanlvxqs	232	61	JAB1	JAB1	NNP
cord-296347-fanlvxqs	232	62	/	/	SYM
cord-296347-fanlvxqs	232	63	MPN	MPN	NNP
cord-296347-fanlvxqs	232	64	/	/	SYM
cord-296347-fanlvxqs	232	65	Mov34	Mov34	NNP
cord-296347-fanlvxqs	232	66	proteases	protease	NNS
cord-296347-fanlvxqs	232	67	(	(	-LRB-
cord-296347-fanlvxqs	232	68	JAMMs	jamm	NNS
cord-296347-fanlvxqs	232	69	)	)	-RRB-
cord-296347-fanlvxqs	232	70	.	.	.
cord-296347-fanlvxqs	233	1	The	the	DT
cord-296347-fanlvxqs	233	2	first	first	JJ
cord-296347-fanlvxqs	233	3	four	four	CD
cord-296347-fanlvxqs	233	4	classes	class	NNS
cord-296347-fanlvxqs	233	5	comprise	comprise	VBP
cord-296347-fanlvxqs	233	6	cysteine	cysteine	NN
cord-296347-fanlvxqs	233	7	-	-	HYPH
cord-296347-fanlvxqs	233	8	type	type	NN
cord-296347-fanlvxqs	233	9	proteases	protease	NNS
cord-296347-fanlvxqs	233	10	,	,	,
cord-296347-fanlvxqs	233	11	whereas	whereas	IN
cord-296347-fanlvxqs	233	12	JAMMs	jamm	NNS
cord-296347-fanlvxqs	233	13	are	be	VBP
cord-296347-fanlvxqs	233	14	metalloproteases	metalloprotease	NNS
cord-296347-fanlvxqs	233	15	.	.	.
cord-296347-fanlvxqs	234	1	For	for	IN
cord-296347-fanlvxqs	234	2	a	a	DT
cord-296347-fanlvxqs	234	3	more	more	RBR
cord-296347-fanlvxqs	234	4	detailed	detailed	JJ
cord-296347-fanlvxqs	234	5	inventory	inventory	NN
cord-296347-fanlvxqs	234	6	of	of	IN
cord-296347-fanlvxqs	234	7	DUBs	dub	NNS
cord-296347-fanlvxqs	234	8	,	,	,
cord-296347-fanlvxqs	234	9	read	read	VBD
cord-296347-fanlvxqs	234	10	Nijman	Nijman	NNP
cord-296347-fanlvxqs	234	11	et	et	NNP
cord-296347-fanlvxqs	234	12	al	al	NNP
cord-296347-fanlvxqs	234	13	.	.	.
cord-296347-fanlvxqs	235	1	(	(	-LRB-
cord-296347-fanlvxqs	235	2	2005	2005	CD
cord-296347-fanlvxqs	235	3	)	)	-RRB-
cord-296347-fanlvxqs	235	4	.	.	.
cord-296347-fanlvxqs	236	1	DUBs	dub	NNS
cord-296347-fanlvxqs	236	2	have	have	VBP
cord-296347-fanlvxqs	236	3	very	very	RB
cord-296347-fanlvxqs	236	4	diverse	diverse	JJ
cord-296347-fanlvxqs	236	5	specificity	specificity	NN
cord-296347-fanlvxqs	236	6	properties	property	NNS
cord-296347-fanlvxqs	236	7	,	,	,
cord-296347-fanlvxqs	236	8	in	in	IN
cord-296347-fanlvxqs	236	9	terms	term	NNS
cord-296347-fanlvxqs	236	10	of	of	IN
cord-296347-fanlvxqs	236	11	the	the	DT
cord-296347-fanlvxqs	236	12	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	236	13	or	or	CC
cord-296347-fanlvxqs	236	14	Ubl	Ubl	NNP
cord-296347-fanlvxqs	236	15	moiety	moiety	NN
cord-296347-fanlvxqs	236	16	itself	-PRON-	PRP
cord-296347-fanlvxqs	236	17	(	(	-LRB-
cord-296347-fanlvxqs	236	18	substrate	substrate	NN
cord-296347-fanlvxqs	236	19	specificity	specificity	NN
cord-296347-fanlvxqs	236	20	)	)	-RRB-
cord-296347-fanlvxqs	236	21	,	,	,
cord-296347-fanlvxqs	236	22	in	in	IN
cord-296347-fanlvxqs	236	23	terms	term	NNS
cord-296347-fanlvxqs	236	24	of	of	IN
cord-296347-fanlvxqs	236	25	the	the	DT
cord-296347-fanlvxqs	236	26	target	target	NN
cord-296347-fanlvxqs	236	27	protein	protein	NN
cord-296347-fanlvxqs	236	28	to	to	TO
cord-296347-fanlvxqs	236	29	which	which	WDT
cord-296347-fanlvxqs	236	30	the	the	DT
cord-296347-fanlvxqs	236	31	Ub	Ub	NNP
cord-296347-fanlvxqs	236	32	or	or	CC
cord-296347-fanlvxqs	236	33	Ubl	Ubl	NNP
cord-296347-fanlvxqs	236	34	is	be	VBZ
cord-296347-fanlvxqs	236	35	attached	attach	VBN
cord-296347-fanlvxqs	236	36	(	(	-LRB-
cord-296347-fanlvxqs	236	37	target	target	NN
cord-296347-fanlvxqs	236	38	specificity	specificity	NN
cord-296347-fanlvxqs	236	39	)	)	-RRB-
cord-296347-fanlvxqs	236	40	,	,	,
cord-296347-fanlvxqs	236	41	and	and	CC
cord-296347-fanlvxqs	236	42	possibly	possibly	RB
cord-296347-fanlvxqs	236	43	in	in	IN
cord-296347-fanlvxqs	236	44	terms	term	NNS
cord-296347-fanlvxqs	236	45	of	of	IN
cord-296347-fanlvxqs	236	46	the	the	DT
cord-296347-fanlvxqs	236	47	context	context	NN
cord-296347-fanlvxqs	236	48	provided	provide	VBN
cord-296347-fanlvxqs	236	49	by	by	IN
cord-296347-fanlvxqs	236	50	target	target	NN
cord-296347-fanlvxqs	236	51	and	and	CC
cord-296347-fanlvxqs	236	52	attached	attach	VBN
cord-296347-fanlvxqs	236	53	modification	modification	NN
cord-296347-fanlvxqs	236	54	.	.	.
cord-296347-fanlvxqs	237	1	DUB	dub	NN
cord-296347-fanlvxqs	237	2	specificity	specificity	NN
cord-296347-fanlvxqs	237	3	in	in	IN
cord-296347-fanlvxqs	237	4	vivo	vivo	NN
cord-296347-fanlvxqs	237	5	can	can	MD
cord-296347-fanlvxqs	237	6	be	be	VB
cord-296347-fanlvxqs	237	7	further	further	RB
cord-296347-fanlvxqs	237	8	regulated	regulate	VBN
cord-296347-fanlvxqs	237	9	by	by	IN
cord-296347-fanlvxqs	237	10	subcellular	subcellular	JJ
cord-296347-fanlvxqs	237	11	localization	localization	NN
cord-296347-fanlvxqs	237	12	or	or	CC
cord-296347-fanlvxqs	237	13	association	association	NN
cord-296347-fanlvxqs	237	14	with	with	IN
cord-296347-fanlvxqs	237	15	different	different	JJ
cord-296347-fanlvxqs	237	16	binding	bind	VBG
cord-296347-fanlvxqs	237	17	partners	partner	NNS
cord-296347-fanlvxqs	237	18	(	(	-LRB-
cord-296347-fanlvxqs	237	19	Amerik	Amerik	NNP
cord-296347-fanlvxqs	237	20	and	and	CC
cord-296347-fanlvxqs	237	21	Hochstrasser	Hochstrasser	NNP
cord-296347-fanlvxqs	237	22	,	,	,
cord-296347-fanlvxqs	237	23	2004	2004	CD
cord-296347-fanlvxqs	237	24	;	;	:
cord-296347-fanlvxqs	237	25	Li	Li	NNP
cord-296347-fanlvxqs	237	26	and	and	CC
cord-296347-fanlvxqs	237	27	Hochstrasser	Hochstrasser	NNP
cord-296347-fanlvxqs	237	28	,	,	,
cord-296347-fanlvxqs	237	29	2003	2003	CD
cord-296347-fanlvxqs	237	30	;	;	:
cord-296347-fanlvxqs	238	1	Reyes	Reyes	NNP
cord-296347-fanlvxqs	238	2	-	-	HYPH
cord-296347-fanlvxqs	238	3	Turcu	Turcu	NNP
cord-296347-fanlvxqs	238	4	et	et	FW
cord-296347-fanlvxqs	238	5	al	al	NNP
cord-296347-fanlvxqs	238	6	.	.	NNP
cord-296347-fanlvxqs	238	7	,	,	,
cord-296347-fanlvxqs	238	8	2006	2006	CD
cord-296347-fanlvxqs	238	9	;	;	:
cord-296347-fanlvxqs	238	10	Soboleva	Soboleva	NNP
cord-296347-fanlvxqs	238	11	and	and	CC
cord-296347-fanlvxqs	238	12	Baker	Baker	NNP
cord-296347-fanlvxqs	238	13	,	,	,
cord-296347-fanlvxqs	238	14	2004	2004	CD
cord-296347-fanlvxqs	238	15	)	)	-RRB-
cord-296347-fanlvxqs	238	16	.	.	.
cord-296347-fanlvxqs	239	1	DUB	dub	NN
cord-296347-fanlvxqs	239	2	functions	function	NNS
cord-296347-fanlvxqs	239	3	are	be	VBP
cord-296347-fanlvxqs	239	4	therefore	therefore	RB
cord-296347-fanlvxqs	239	5	also	also	RB
cord-296347-fanlvxqs	239	6	extremely	extremely	RB
cord-296347-fanlvxqs	239	7	diverse	diverse	JJ
cord-296347-fanlvxqs	239	8	,	,	,
cord-296347-fanlvxqs	239	9	ranging	range	VBG
cord-296347-fanlvxqs	239	10	from	from	IN
cord-296347-fanlvxqs	239	11	regulation	regulation	NN
cord-296347-fanlvxqs	239	12	of	of	IN
cord-296347-fanlvxqs	239	13	proteasome	proteasome	NN
cord-296347-fanlvxqs	239	14	function	function	NN
cord-296347-fanlvxqs	239	15	,	,	,
cord-296347-fanlvxqs	239	16	to	to	IN
cord-296347-fanlvxqs	239	17	regulation	regulation	NN
cord-296347-fanlvxqs	239	18	of	of	IN
cord-296347-fanlvxqs	239	19	chromatin	chromatin	NN
cord-296347-fanlvxqs	239	20	structure	structure	NN
cord-296347-fanlvxqs	239	21	,	,	,
cord-296347-fanlvxqs	239	22	to	to	TO
cord-296347-fanlvxqs	239	23	membrane	membrane	NN
cord-296347-fanlvxqs	239	24	protein	protein	NN
cord-296347-fanlvxqs	239	25	trafficking	trafficking	NN
cord-296347-fanlvxqs	239	26	,	,	,
cord-296347-fanlvxqs	239	27	and	and	CC
cord-296347-fanlvxqs	239	28	with	with	IN
cord-296347-fanlvxqs	239	29	obvious	obvious	JJ
cord-296347-fanlvxqs	239	30	implications	implication	NNS
cord-296347-fanlvxqs	239	31	in	in	IN
cord-296347-fanlvxqs	239	32	processes	process	NNS
cord-296347-fanlvxqs	239	33	such	such	JJ
cord-296347-fanlvxqs	239	34	as	as	IN
cord-296347-fanlvxqs	239	35	cancer	cancer	NN
cord-296347-fanlvxqs	239	36	and	and	CC
cord-296347-fanlvxqs	239	37	neurodegeneration	neurodegeneration	NN
cord-296347-fanlvxqs	239	38	(	(	-LRB-
cord-296347-fanlvxqs	239	39	Amerik	Amerik	NNP
cord-296347-fanlvxqs	239	40	and	and	CC
cord-296347-fanlvxqs	239	41	Hochstrasser	Hochstrasser	NNP
cord-296347-fanlvxqs	239	42	,	,	,
cord-296347-fanlvxqs	239	43	2004	2004	CD
cord-296347-fanlvxqs	239	44	;	;	:
cord-296347-fanlvxqs	240	1	Nijman	Nijman	NNP
cord-296347-fanlvxqs	240	2	et	et	NNP
cord-296347-fanlvxqs	240	3	al	al	NNP
cord-296347-fanlvxqs	240	4	.	.	NNP
cord-296347-fanlvxqs	240	5	,	,	,
cord-296347-fanlvxqs	240	6	2005	2005	CD
cord-296347-fanlvxqs	240	7	;	;	:
cord-296347-fanlvxqs	241	1	Soboleva	Soboleva	NNP
cord-296347-fanlvxqs	241	2	and	and	CC
cord-296347-fanlvxqs	241	3	Baker	Baker	NNP
cord-296347-fanlvxqs	241	4	,	,	,
cord-296347-fanlvxqs	241	5	2004	2004	CD
cord-296347-fanlvxqs	241	6	)	)	-RRB-
cord-296347-fanlvxqs	241	7	.	.	.
cord-296347-fanlvxqs	242	1	The	the	DT
cord-296347-fanlvxqs	242	2	proteasome	proteasome	NN
cord-296347-fanlvxqs	242	3	,	,	,
cord-296347-fanlvxqs	242	4	very	very	RB
cord-296347-fanlvxqs	242	5	abundant	abundant	JJ
cord-296347-fanlvxqs	242	6	in	in	IN
cord-296347-fanlvxqs	242	7	the	the	DT
cord-296347-fanlvxqs	242	8	cytosol	cytosol	NN
cord-296347-fanlvxqs	242	9	,	,	,
cord-296347-fanlvxqs	242	10	is	be	VBZ
cord-296347-fanlvxqs	242	11	a	a	DT
cord-296347-fanlvxqs	242	12	multisubunit	multisubunit	NN
cord-296347-fanlvxqs	242	13	protease	protease	NN
cord-296347-fanlvxqs	242	14	composed	compose	VBN
cord-296347-fanlvxqs	242	15	of	of	IN
cord-296347-fanlvxqs	242	16	the	the	DT
cord-296347-fanlvxqs	242	17	20S	20s	CD
cord-296347-fanlvxqs	242	18	and	and	CC
cord-296347-fanlvxqs	242	19	19S	19s	CD
cord-296347-fanlvxqs	242	20	proteasome	proteasome	NN
cord-296347-fanlvxqs	242	21	complexes	complex	NNS
cord-296347-fanlvxqs	242	22	.	.	.
cord-296347-fanlvxqs	243	1	The	the	DT
cord-296347-fanlvxqs	243	2	20S	20s	CD
cord-296347-fanlvxqs	243	3	proteasome	proteasome	NN
cord-296347-fanlvxqs	243	4	(	(	-LRB-
cord-296347-fanlvxqs	243	5	or	or	CC
cord-296347-fanlvxqs	243	6	central	central	JJ
cord-296347-fanlvxqs	243	7	core	core	NN
cord-296347-fanlvxqs	243	8	particle	particle	NN
cord-296347-fanlvxqs	243	9	)	)	-RRB-
cord-296347-fanlvxqs	243	10	has	have	VBZ
cord-296347-fanlvxqs	243	11	the	the	DT
cord-296347-fanlvxqs	243	12	general	general	JJ
cord-296347-fanlvxqs	243	13	architecture	architecture	NN
cord-296347-fanlvxqs	243	14	of	of	IN
cord-296347-fanlvxqs	243	15	a	a	DT
cord-296347-fanlvxqs	243	16	barrel	barrel	NN
cord-296347-fanlvxqs	243	17	,	,	,
cord-296347-fanlvxqs	243	18	formed	form	VBN
cord-296347-fanlvxqs	243	19	by	by	IN
cord-296347-fanlvxqs	243	20	four	four	CD
cord-296347-fanlvxqs	243	21	stacked	stack	VBN
cord-296347-fanlvxqs	243	22	rings	ring	NNS
cord-296347-fanlvxqs	243	23	of	of	IN
cord-296347-fanlvxqs	243	24	seven	seven	CD
cord-296347-fanlvxqs	243	25	subunits	subunit	NNS
cord-296347-fanlvxqs	243	26	each	each	DT
cord-296347-fanlvxqs	243	27	,	,	,
cord-296347-fanlvxqs	243	28	the	the	DT
cord-296347-fanlvxqs	243	29	outer	outer	JJ
cord-296347-fanlvxqs	243	30	two	two	CD
cord-296347-fanlvxqs	243	31	rings	ring	NNS
cord-296347-fanlvxqs	243	32	being	be	VBG
cord-296347-fanlvxqs	243	33	composed	compose	VBN
cord-296347-fanlvxqs	243	34	of	of	IN
cord-296347-fanlvxqs	243	35	a	a	DT
cord-296347-fanlvxqs	243	36	subunits	subunit	NNS
cord-296347-fanlvxqs	243	37	and	and	CC
cord-296347-fanlvxqs	243	38	the	the	DT
cord-296347-fanlvxqs	243	39	innermost	innermost	JJS
cord-296347-fanlvxqs	243	40	two	two	CD
cord-296347-fanlvxqs	243	41	rings	ring	NNS
cord-296347-fanlvxqs	243	42	of	of	IN
cord-296347-fanlvxqs	243	43	b	b	NN
cord-296347-fanlvxqs	243	44	subunits	subunit	NNS
cord-296347-fanlvxqs	243	45	(	(	-LRB-
cord-296347-fanlvxqs	243	46	Groll	Groll	NNP
cord-296347-fanlvxqs	243	47	et	et	NNP
cord-296347-fanlvxqs	243	48	al	al	NNP
cord-296347-fanlvxqs	243	49	.	.	NNP
cord-296347-fanlvxqs	243	50	,	,	,
cord-296347-fanlvxqs	243	51	1997	1997	CD
cord-296347-fanlvxqs	243	52	)	)	-RRB-
cord-296347-fanlvxqs	243	53	.	.	.
cord-296347-fanlvxqs	244	1	The	the	DT
cord-296347-fanlvxqs	244	2	b	b	NN
cord-296347-fanlvxqs	244	3	subunits	subunit	NNS
cord-296347-fanlvxqs	244	4	,	,	,
cord-296347-fanlvxqs	244	5	which	which	WDT
cord-296347-fanlvxqs	244	6	line	line	VBP
cord-296347-fanlvxqs	244	7	the	the	DT
cord-296347-fanlvxqs	244	8	proteasome	proteasome	NN
cord-296347-fanlvxqs	244	9	's	's	POS
cord-296347-fanlvxqs	244	10	inner	inner	JJ
cord-296347-fanlvxqs	244	11	cavity	cavity	NN
cord-296347-fanlvxqs	244	12	,	,	,
cord-296347-fanlvxqs	244	13	carry	carry	VB
cord-296347-fanlvxqs	244	14	out	out	RP
cord-296347-fanlvxqs	244	15	the	the	DT
cord-296347-fanlvxqs	244	16	catalytic	catalytic	JJ
cord-296347-fanlvxqs	244	17	activity	activity	NN
cord-296347-fanlvxqs	244	18	.	.	.
cord-296347-fanlvxqs	245	1	For	for	IN
cord-296347-fanlvxqs	245	2	mammalian	mammalian	JJ
cord-296347-fanlvxqs	245	3	proteasomes	proteasome	NNS
cord-296347-fanlvxqs	245	4	,	,	,
cord-296347-fanlvxqs	245	5	only	only	RB
cord-296347-fanlvxqs	245	6	three	three	CD
cord-296347-fanlvxqs	245	7	of	of	IN
cord-296347-fanlvxqs	245	8	the	the	DT
cord-296347-fanlvxqs	245	9	seven	seven	CD
cord-296347-fanlvxqs	245	10	b	b	NN
cord-296347-fanlvxqs	245	11	subunits	subunit	NNS
cord-296347-fanlvxqs	245	12	in	in	IN
cord-296347-fanlvxqs	245	13	each	each	DT
cord-296347-fanlvxqs	245	14	ring	ring	NN
cord-296347-fanlvxqs	245	15	are	be	VBP
cord-296347-fanlvxqs	245	16	catalytically	catalytically	RB
cord-296347-fanlvxqs	245	17	active	active	JJ
cord-296347-fanlvxqs	245	18	.	.	.
cord-296347-fanlvxqs	246	1	Access	access	NN
cord-296347-fanlvxqs	246	2	to	to	IN
cord-296347-fanlvxqs	246	3	this	this	DT
cord-296347-fanlvxqs	246	4	cavity	cavity	NN
cord-296347-fanlvxqs	246	5	occurs	occur	VBZ
cord-296347-fanlvxqs	246	6	through	through	IN
cord-296347-fanlvxqs	246	7	narrow	narrow	JJ
cord-296347-fanlvxqs	246	8	pores	pore	NNS
cord-296347-fanlvxqs	246	9	(	(	-LRB-
cord-296347-fanlvxqs	246	10	with	with	IN
cord-296347-fanlvxqs	246	11	a	a	DT
cord-296347-fanlvxqs	246	12	diameter	diameter	NN
cord-296347-fanlvxqs	246	13	on	on	IN
cord-296347-fanlvxqs	246	14	the	the	DT
cord-296347-fanlvxqs	246	15	order	order	NN
cord-296347-fanlvxqs	246	16	of	of	IN
cord-296347-fanlvxqs	246	17	10	10	CD
cord-296347-fanlvxqs	246	18	-	-	SYM
cord-296347-fanlvxqs	246	19	15	15	CD
cord-296347-fanlvxqs	246	20	Å	å	NN
cord-296347-fanlvxqs	246	21	)	)	-RRB-
cord-296347-fanlvxqs	246	22	at	at	IN
cord-296347-fanlvxqs	246	23	both	both	DT
cord-296347-fanlvxqs	246	24	ends	end	NNS
cord-296347-fanlvxqs	246	25	of	of	IN
cord-296347-fanlvxqs	246	26	the	the	DT
cord-296347-fanlvxqs	246	27	barrel	barrel	NN
cord-296347-fanlvxqs	246	28	,	,	,
cord-296347-fanlvxqs	246	29	so	so	CC
cord-296347-fanlvxqs	246	30	it	-PRON-	PRP
cord-296347-fanlvxqs	246	31	is	be	VBZ
cord-296347-fanlvxqs	246	32	usually	usually	RB
cord-296347-fanlvxqs	246	33	assumed	assume	VBN
cord-296347-fanlvxqs	246	34	that	that	IN
cord-296347-fanlvxqs	246	35	protein	protein	NN
cord-296347-fanlvxqs	246	36	substrates	substrate	NNS
cord-296347-fanlvxqs	246	37	must	must	MD
cord-296347-fanlvxqs	246	38	be	be	VB
cord-296347-fanlvxqs	246	39	unfolded	unfold	VBN
cord-296347-fanlvxqs	246	40	prior	prior	RB
cord-296347-fanlvxqs	246	41	to	to	IN
cord-296347-fanlvxqs	246	42	their	-PRON-	PRP$
cord-296347-fanlvxqs	246	43	delivery	delivery	NN
cord-296347-fanlvxqs	246	44	to	to	IN
cord-296347-fanlvxqs	246	45	the	the	DT
cord-296347-fanlvxqs	246	46	catalytic	catalytic	JJ
cord-296347-fanlvxqs	246	47	chamber	chamber	NN
cord-296347-fanlvxqs	246	48	(	(	-LRB-
cord-296347-fanlvxqs	246	49	Groll	Groll	NNP
cord-296347-fanlvxqs	246	50	et	et	NNP
cord-296347-fanlvxqs	246	51	al	al	NNP
cord-296347-fanlvxqs	246	52	.	.	NNP
cord-296347-fanlvxqs	246	53	,	,	,
cord-296347-fanlvxqs	246	54	1997	1997	CD
cord-296347-fanlvxqs	247	1	(	(	-LRB-
cord-296347-fanlvxqs	247	2	Groll	Groll	NNP
cord-296347-fanlvxqs	247	3	et	et	NNP
cord-296347-fanlvxqs	247	4	al	al	NNP
cord-296347-fanlvxqs	247	5	.	.	.
cord-296347-fanlvxqs	248	1	,	,	,
cord-296347-fanlvxqs	248	2	,	,	,
cord-296347-fanlvxqs	248	3	2000	2000	CD
cord-296347-fanlvxqs	248	4	Kohler	Kohler	NNP
cord-296347-fanlvxqs	248	5	et	et	NNP
cord-296347-fanlvxqs	248	6	al	al	NNP
cord-296347-fanlvxqs	248	7	.	.	NNP
cord-296347-fanlvxqs	248	8	,	,	,
cord-296347-fanlvxqs	248	9	2001	2001	CD
cord-296347-fanlvxqs	248	10	)	)	-RRB-
cord-296347-fanlvxqs	248	11	.	.	.
cord-296347-fanlvxqs	249	1	Also	also	RB
cord-296347-fanlvxqs	249	2	at	at	IN
cord-296347-fanlvxqs	249	3	both	both	DT
cord-296347-fanlvxqs	249	4	ends	end	NNS
cord-296347-fanlvxqs	249	5	of	of	IN
cord-296347-fanlvxqs	249	6	the	the	DT
cord-296347-fanlvxqs	249	7	core	core	NN
cord-296347-fanlvxqs	249	8	particle	particle	NN
cord-296347-fanlvxqs	249	9	there	there	EX
cord-296347-fanlvxqs	249	10	is	be	VBZ
cord-296347-fanlvxqs	249	11	the	the	DT
cord-296347-fanlvxqs	249	12	19S	19s	CD
cord-296347-fanlvxqs	249	13	cap	cap	NN
cord-296347-fanlvxqs	249	14	complex	complex	NN
cord-296347-fanlvxqs	249	15	,	,	,
cord-296347-fanlvxqs	249	16	whose	whose	WP$
cord-296347-fanlvxqs	249	17	functions	function	NNS
cord-296347-fanlvxqs	249	18	range	range	VBP
cord-296347-fanlvxqs	249	19	from	from	IN
cord-296347-fanlvxqs	249	20	recognition	recognition	NN
cord-296347-fanlvxqs	249	21	of	of	IN
cord-296347-fanlvxqs	249	22	poly	poly	JJ
cord-296347-fanlvxqs	249	23	-	-	HYPH
cord-296347-fanlvxqs	249	24	Ub	ub	JJ
cord-296347-fanlvxqs	249	25	chains	chain	NNS
cord-296347-fanlvxqs	249	26	on	on	IN
cord-296347-fanlvxqs	249	27	target	target	NN
cord-296347-fanlvxqs	249	28	proteins	protein	NNS
cord-296347-fanlvxqs	249	29	,	,	,
cord-296347-fanlvxqs	249	30	to	to	IN
cord-296347-fanlvxqs	249	31	unfolding	unfold	VBG
cord-296347-fanlvxqs	249	32	of	of	IN
cord-296347-fanlvxqs	249	33	the	the	DT
cord-296347-fanlvxqs	249	34	substrate	substrate	NN
cord-296347-fanlvxqs	249	35	to	to	TO
cord-296347-fanlvxqs	249	36	facilitate	facilitate	VB
cord-296347-fanlvxqs	249	37	entry	entry	NN
cord-296347-fanlvxqs	249	38	into	into	IN
cord-296347-fanlvxqs	249	39	the	the	DT
cord-296347-fanlvxqs	249	40	catalytic	catalytic	JJ
cord-296347-fanlvxqs	249	41	cavity	cavity	NN
cord-296347-fanlvxqs	249	42	,	,	,
cord-296347-fanlvxqs	249	43	to	to	IN
cord-296347-fanlvxqs	249	44	deubiquitination	deubiquitination	NN
cord-296347-fanlvxqs	249	45	activity	activity	NN
cord-296347-fanlvxqs	249	46	(	(	-LRB-
cord-296347-fanlvxqs	249	47	Adams	Adams	NNP
cord-296347-fanlvxqs	249	48	,	,	,
cord-296347-fanlvxqs	249	49	2003	2003	CD
cord-296347-fanlvxqs	249	50	;	;	:
cord-296347-fanlvxqs	250	1	Heinemeyer	Heinemeyer	NNP
cord-296347-fanlvxqs	250	2	et	et	NNP
cord-296347-fanlvxqs	250	3	al	al	NNP
cord-296347-fanlvxqs	250	4	.	.	NNP
cord-296347-fanlvxqs	250	5	,	,	,
cord-296347-fanlvxqs	250	6	2004	2004	CD
cord-296347-fanlvxqs	251	1	;	;	:
cord-296347-fanlvxqs	251	2	Rivett	Rivett	NNP
cord-296347-fanlvxqs	251	3	et	et	FW
cord-296347-fanlvxqs	251	4	al	al	NNP
cord-296347-fanlvxqs	251	5	.	.	NNP
cord-296347-fanlvxqs	251	6	,	,	,
cord-296347-fanlvxqs	251	7	1997	1997	CD
cord-296347-fanlvxqs	251	8	;	;	:
cord-296347-fanlvxqs	251	9	Schmidt	Schmidt	NNP
cord-296347-fanlvxqs	251	10	et	et	NNP
cord-296347-fanlvxqs	251	11	al	al	NNP
cord-296347-fanlvxqs	251	12	.	.	.
cord-296347-fanlvxqs	252	1	,	,	,
cord-296347-fanlvxqs	252	2	2005	2005	CD
cord-296347-fanlvxqs	252	3	;	;	:
cord-296347-fanlvxqs	252	4	Seeger	Seeger	NNP
cord-296347-fanlvxqs	252	5	et	et	NNP
cord-296347-fanlvxqs	252	6	al	al	NNP
cord-296347-fanlvxqs	252	7	.	.	NNP
cord-296347-fanlvxqs	252	8	,	,	,
cord-296347-fanlvxqs	252	9	1997	1997	CD
cord-296347-fanlvxqs	252	10	)	)	-RRB-
cord-296347-fanlvxqs	252	11	.	.	.
cord-296347-fanlvxqs	253	1	As	as	IN
cord-296347-fanlvxqs	253	2	mentioned	mention	VBN
cord-296347-fanlvxqs	253	3	earlier	early	RBR
cord-296347-fanlvxqs	253	4	,	,	,
cord-296347-fanlvxqs	253	5	the	the	DT
cord-296347-fanlvxqs	253	6	proteasome	proteasome	NN
cord-296347-fanlvxqs	253	7	plays	play	VBZ
cord-296347-fanlvxqs	253	8	an	an	DT
cord-296347-fanlvxqs	253	9	instrumental	instrumental	JJ
cord-296347-fanlvxqs	253	10	role	role	NN
cord-296347-fanlvxqs	253	11	in	in	IN
cord-296347-fanlvxqs	253	12	class	class	NN
cord-296347-fanlvxqs	253	13	I	-PRON-	PRP
cord-296347-fanlvxqs	253	14	MHC	MHC	NNP
cord-296347-fanlvxqs	253	15	antigen	antigen	NN
cord-296347-fanlvxqs	253	16	presentation	presentation	NN
cord-296347-fanlvxqs	253	17	and	and	CC
cord-296347-fanlvxqs	253	18	activation	activation	NN
cord-296347-fanlvxqs	253	19	of	of	IN
cord-296347-fanlvxqs	253	20	peptide	peptide	NN
cord-296347-fanlvxqs	253	21	-	-	HYPH
cord-296347-fanlvxqs	253	22	specific	specific	JJ
cord-296347-fanlvxqs	253	23	CD8	CD8	NNP
cord-296347-fanlvxqs	253	24	þ	þ	NNP
cord-296347-fanlvxqs	253	25	T	T	NNP
cord-296347-fanlvxqs	253	26	cell	cell	NN
cord-296347-fanlvxqs	253	27	responses	response	NNS
cord-296347-fanlvxqs	253	28	.	.	.
cord-296347-fanlvxqs	254	1	This	this	DT
cord-296347-fanlvxqs	254	2	process	process	NN
cord-296347-fanlvxqs	254	3	requires	require	VBZ
cord-296347-fanlvxqs	254	4	not	not	RB
cord-296347-fanlvxqs	254	5	only	only	RB
cord-296347-fanlvxqs	254	6	generation	generation	NN
cord-296347-fanlvxqs	254	7	of	of	IN
cord-296347-fanlvxqs	254	8	peptides	peptide	NNS
cord-296347-fanlvxqs	254	9	of	of	IN
cord-296347-fanlvxqs	254	10	the	the	DT
cord-296347-fanlvxqs	254	11	right	right	JJ
cord-296347-fanlvxqs	254	12	quality	quality	NN
cord-296347-fanlvxqs	254	13	-	-	:
cord-296347-fanlvxqs	254	14	that	that	RB
cord-296347-fanlvxqs	254	15	is	is	RB
cord-296347-fanlvxqs	254	16	,	,	,
cord-296347-fanlvxqs	254	17	right	right	JJ
cord-296347-fanlvxqs	254	18	size	size	NN
cord-296347-fanlvxqs	254	19	and	and	CC
cord-296347-fanlvxqs	254	20	sequence	sequence	NN
cord-296347-fanlvxqs	254	21	to	to	TO
cord-296347-fanlvxqs	254	22	allow	allow	VB
cord-296347-fanlvxqs	254	23	a	a	DT
cord-296347-fanlvxqs	254	24	correct	correct	JJ
cord-296347-fanlvxqs	254	25	fit	fit	NN
cord-296347-fanlvxqs	254	26	into	into	IN
cord-296347-fanlvxqs	254	27	the	the	DT
cord-296347-fanlvxqs	254	28	peptidebinding	peptidebinde	VBG
cord-296347-fanlvxqs	254	29	cleft	cleft	NN
cord-296347-fanlvxqs	254	30	-	-	:
cord-296347-fanlvxqs	254	31	but	but	CC
cord-296347-fanlvxqs	254	32	also	also	RB
cord-296347-fanlvxqs	254	33	in	in	IN
cord-296347-fanlvxqs	254	34	the	the	DT
cord-296347-fanlvxqs	254	35	right	right	JJ
cord-296347-fanlvxqs	254	36	quantity	quantity	NN
cord-296347-fanlvxqs	254	37	to	to	TO
cord-296347-fanlvxqs	254	38	trigger	trigger	VB
cord-296347-fanlvxqs	254	39	a	a	DT
cord-296347-fanlvxqs	254	40	successful	successful	JJ
cord-296347-fanlvxqs	254	41	response	response	NN
cord-296347-fanlvxqs	254	42	,	,	,
cord-296347-fanlvxqs	254	43	which	which	WDT
cord-296347-fanlvxqs	254	44	is	be	VBZ
cord-296347-fanlvxqs	254	45	no	no	DT
cord-296347-fanlvxqs	254	46	small	small	JJ
cord-296347-fanlvxqs	254	47	endeavor	endeavor	NN
cord-296347-fanlvxqs	254	48	due	due	IN
cord-296347-fanlvxqs	254	49	to	to	IN
cord-296347-fanlvxqs	254	50	many	many	JJ
cord-296347-fanlvxqs	254	51	destructive	destructive	JJ
cord-296347-fanlvxqs	254	52	aminopeptidase	aminopeptidase	NN
cord-296347-fanlvxqs	254	53	activities	activity	NNS
cord-296347-fanlvxqs	254	54	in	in	IN
cord-296347-fanlvxqs	254	55	the	the	DT
cord-296347-fanlvxqs	254	56	cytosol	cytosol	NN
cord-296347-fanlvxqs	254	57	(	(	-LRB-
cord-296347-fanlvxqs	254	58	Shastri	Shastri	NNP
cord-296347-fanlvxqs	254	59	et	et	NNP
cord-296347-fanlvxqs	254	60	al	al	NNP
cord-296347-fanlvxqs	254	61	.	.	NNP
cord-296347-fanlvxqs	254	62	,	,	,
cord-296347-fanlvxqs	254	63	2005	2005	CD
cord-296347-fanlvxqs	254	64	;	;	:
cord-296347-fanlvxqs	254	65	Strehl	Strehl	NNP
cord-296347-fanlvxqs	254	66	et	et	NNP
cord-296347-fanlvxqs	254	67	al	al	NNP
cord-296347-fanlvxqs	254	68	.	.	NNP
cord-296347-fanlvxqs	254	69	,	,	,
cord-296347-fanlvxqs	254	70	2005	2005	CD
cord-296347-fanlvxqs	254	71	)	)	-RRB-
cord-296347-fanlvxqs	254	72	.	.	.
cord-296347-fanlvxqs	255	1	IFN	IFN	NNP
cord-296347-fanlvxqs	255	2	-	-	HYPH
cord-296347-fanlvxqs	255	3	g	g	NNP
cord-296347-fanlvxqs	255	4	,	,	,
cord-296347-fanlvxqs	255	5	a	a	DT
cord-296347-fanlvxqs	255	6	crucial	crucial	JJ
cord-296347-fanlvxqs	255	7	component	component	NN
cord-296347-fanlvxqs	255	8	of	of	IN
cord-296347-fanlvxqs	255	9	the	the	DT
cord-296347-fanlvxqs	255	10	innate	innate	JJ
cord-296347-fanlvxqs	255	11	and	and	CC
cord-296347-fanlvxqs	255	12	adaptive	adaptive	JJ
cord-296347-fanlvxqs	255	13	antiviral	antiviral	JJ
cord-296347-fanlvxqs	255	14	immune	immune	JJ
cord-296347-fanlvxqs	255	15	responses	response	NNS
cord-296347-fanlvxqs	255	16	,	,	,
cord-296347-fanlvxqs	255	17	affords	afford	VBZ
cord-296347-fanlvxqs	255	18	the	the	DT
cord-296347-fanlvxqs	255	19	immune	immune	JJ
cord-296347-fanlvxqs	255	20	system	system	NN
cord-296347-fanlvxqs	255	21	a	a	DT
cord-296347-fanlvxqs	255	22	competitive	competitive	JJ
cord-296347-fanlvxqs	255	23	edge	edge	NN
cord-296347-fanlvxqs	255	24	.	.	.
cord-296347-fanlvxqs	256	1	IFN	IFN	NNP
cord-296347-fanlvxqs	256	2	-	-	HYPH
cord-296347-fanlvxqs	256	3	g	g	NNP
cord-296347-fanlvxqs	256	4	induces	induce	VBZ
cord-296347-fanlvxqs	256	5	expression	expression	NN
cord-296347-fanlvxqs	256	6	of	of	IN
cord-296347-fanlvxqs	256	7	auxiliary	auxiliary	JJ
cord-296347-fanlvxqs	256	8	b	b	NN
cord-296347-fanlvxqs	256	9	subunits	subunit	NNS
cord-296347-fanlvxqs	256	10	,	,	,
cord-296347-fanlvxqs	256	11	b1i	b1i	NNP
cord-296347-fanlvxqs	256	12	,	,	,
cord-296347-fanlvxqs	256	13	b5i	b5i	CD
cord-296347-fanlvxqs	256	14	,	,	,
cord-296347-fanlvxqs	256	15	and	and	CC
cord-296347-fanlvxqs	256	16	b2i	b2i	NNP
cord-296347-fanlvxqs	256	17	[	[	-LRB-
cord-296347-fanlvxqs	256	18	also	also	RB
cord-296347-fanlvxqs	256	19	known	know	VBN
cord-296347-fanlvxqs	256	20	as	as	IN
cord-296347-fanlvxqs	256	21	low	low	JJ
cord-296347-fanlvxqs	256	22	molecular	molecular	JJ
cord-296347-fanlvxqs	256	23	weight	weight	NN
cord-296347-fanlvxqs	256	24	protein	protein	NN
cord-296347-fanlvxqs	256	25	2	2	CD
cord-296347-fanlvxqs	256	26	(	(	-LRB-
cord-296347-fanlvxqs	256	27	LMP2	LMP2	NNP
cord-296347-fanlvxqs	256	28	)	)	-RRB-
cord-296347-fanlvxqs	256	29	,	,	,
cord-296347-fanlvxqs	256	30	LMP7	LMP7	NNP
cord-296347-fanlvxqs	256	31	and	and	CC
cord-296347-fanlvxqs	256	32	multicatalytic	multicatalytic	JJ
cord-296347-fanlvxqs	256	33	endopeptidase	endopeptidase	NN
cord-296347-fanlvxqs	256	34	-	-	HYPH
cord-296347-fanlvxqs	256	35	like	like	JJ
cord-296347-fanlvxqs	256	36	complex	complex	JJ
cord-296347-fanlvxqs	256	37	1	1	CD
cord-296347-fanlvxqs	256	38	(	(	-LRB-
cord-296347-fanlvxqs	256	39	MECL1	MECL1	NNP
cord-296347-fanlvxqs	256	40	)	)	-RRB-
cord-296347-fanlvxqs	256	41	,	,	,
cord-296347-fanlvxqs	256	42	respectively	respectively	RB
cord-296347-fanlvxqs	256	43	]	]	-RRB-
cord-296347-fanlvxqs	256	44	,	,	,
cord-296347-fanlvxqs	256	45	as	as	RB
cord-296347-fanlvxqs	256	46	well	well	RB
cord-296347-fanlvxqs	256	47	as	as	IN
cord-296347-fanlvxqs	256	48	synthesis	synthesis	NN
cord-296347-fanlvxqs	256	49	of	of	IN
cord-296347-fanlvxqs	256	50	the	the	DT
cord-296347-fanlvxqs	256	51	proteasome	proteasome	NN
cord-296347-fanlvxqs	256	52	activator	activator	NN
cord-296347-fanlvxqs	256	53	PA28	PA28	NNP
cord-296347-fanlvxqs	256	54	,	,	,
cord-296347-fanlvxqs	256	55	and	and	CC
cord-296347-fanlvxqs	256	56	of	of	IN
cord-296347-fanlvxqs	256	57	the	the	DT
cord-296347-fanlvxqs	256	58	proteasome	proteasome	NN
cord-296347-fanlvxqs	256	59	maturation	maturation	NN
cord-296347-fanlvxqs	256	60	protein	protein	NN
cord-296347-fanlvxqs	256	61	(	(	-LRB-
cord-296347-fanlvxqs	256	62	POMP	POMP	NNP
cord-296347-fanlvxqs	256	63	)	)	-RRB-
cord-296347-fanlvxqs	256	64	(	(	-LRB-
cord-296347-fanlvxqs	256	65	Strehl	Strehl	NNP
cord-296347-fanlvxqs	256	66	et	et	NNP
cord-296347-fanlvxqs	256	67	al	al	NNP
cord-296347-fanlvxqs	256	68	.	.	NNP
cord-296347-fanlvxqs	256	69	,	,	,
cord-296347-fanlvxqs	256	70	2005	2005	CD
cord-296347-fanlvxqs	256	71	)	)	-RRB-
cord-296347-fanlvxqs	256	72	.	.	.
cord-296347-fanlvxqs	257	1	The	the	DT
cord-296347-fanlvxqs	257	2	immunosubunits	immunosubunit	NNS
cord-296347-fanlvxqs	257	3	LMP2	LMP2	NNP
cord-296347-fanlvxqs	257	4	,	,	,
cord-296347-fanlvxqs	257	5	LMP7	LMP7	NNP
cord-296347-fanlvxqs	257	6	,	,	,
cord-296347-fanlvxqs	257	7	and	and	CC
cord-296347-fanlvxqs	257	8	MECL1	MECL1	NNP
cord-296347-fanlvxqs	257	9	are	be	VBP
cord-296347-fanlvxqs	257	10	incorporated	incorporate	VBN
cord-296347-fanlvxqs	257	11	into	into	IN
cord-296347-fanlvxqs	257	12	nascent	nascent	JJ
cord-296347-fanlvxqs	257	13	proteasomes	proteasome	NNS
cord-296347-fanlvxqs	257	14	,	,	,
cord-296347-fanlvxqs	257	15	replacing	replace	VBG
cord-296347-fanlvxqs	257	16	their	-PRON-	PRP$
cord-296347-fanlvxqs	257	17	endogenous	endogenous	JJ
cord-296347-fanlvxqs	257	18	counterparts	counterpart	NNS
cord-296347-fanlvxqs	257	19	and	and	CC
cord-296347-fanlvxqs	257	20	constituting	constitute	VBG
cord-296347-fanlvxqs	257	21	the	the	DT
cord-296347-fanlvxqs	257	22	so	so	RB
cord-296347-fanlvxqs	257	23	-	-	HYPH
cord-296347-fanlvxqs	257	24	called	call	VBN
cord-296347-fanlvxqs	257	25	immunoproteasome	immunoproteasome	NNP
cord-296347-fanlvxqs	257	26	.	.	.
cord-296347-fanlvxqs	258	1	The	the	DT
cord-296347-fanlvxqs	258	2	proteasome	proteasome	NN
cord-296347-fanlvxqs	258	3	activator	activator	NN
cord-296347-fanlvxqs	258	4	PA28	PA28	NNP
cord-296347-fanlvxqs	258	5	(	(	-LRB-
cord-296347-fanlvxqs	258	6	or	or	CC
cord-296347-fanlvxqs	258	7	11S	11S	NNP
cord-296347-fanlvxqs	258	8	proteasome	proteasome	NN
cord-296347-fanlvxqs	258	9	)	)	-RRB-
cord-296347-fanlvxqs	258	10	binds	bind	VBZ
cord-296347-fanlvxqs	258	11	to	to	IN
cord-296347-fanlvxqs	258	12	the	the	DT
cord-296347-fanlvxqs	258	13	outer	outer	JJ
cord-296347-fanlvxqs	258	14	rings	ring	NNS
cord-296347-fanlvxqs	258	15	of	of	IN
cord-296347-fanlvxqs	258	16	the	the	DT
cord-296347-fanlvxqs	258	17	20S	20S	NNP
cord-296347-fanlvxqs	258	18	proteasome	proteasome	NN
cord-296347-fanlvxqs	258	19	,	,	,
cord-296347-fanlvxqs	258	20	thereby	thereby	RB
cord-296347-fanlvxqs	258	21	opening	open	VBG
cord-296347-fanlvxqs	258	22	the	the	DT
cord-296347-fanlvxqs	258	23	central	central	JJ
cord-296347-fanlvxqs	258	24	gate	gate	NN
cord-296347-fanlvxqs	258	25	and	and	CC
cord-296347-fanlvxqs	258	26	facilitating	facilitate	VBG
cord-296347-fanlvxqs	258	27	substrate	substrate	NN
cord-296347-fanlvxqs	258	28	entry	entry	NN
cord-296347-fanlvxqs	258	29	.	.	.
cord-296347-fanlvxqs	259	1	POMP	POMP	NNP
cord-296347-fanlvxqs	259	2	is	be	VBZ
cord-296347-fanlvxqs	259	3	important	important	JJ
cord-296347-fanlvxqs	259	4	for	for	IN
cord-296347-fanlvxqs	259	5	assembly	assembly	NN
cord-296347-fanlvxqs	259	6	and	and	CC
cord-296347-fanlvxqs	259	7	maturation	maturation	NN
cord-296347-fanlvxqs	259	8	of	of	IN
cord-296347-fanlvxqs	259	9	the	the	DT
cord-296347-fanlvxqs	259	10	proteasome	proteasome	NN
cord-296347-fanlvxqs	259	11	(	(	-LRB-
cord-296347-fanlvxqs	259	12	Strehl	Strehl	NNP
cord-296347-fanlvxqs	259	13	et	et	FW
cord-296347-fanlvxqs	259	14	al	al	NNP
cord-296347-fanlvxqs	259	15	.	.	NNP
cord-296347-fanlvxqs	259	16	,	,	,
cord-296347-fanlvxqs	259	17	2005	2005	CD
cord-296347-fanlvxqs	259	18	)	)	-RRB-
cord-296347-fanlvxqs	259	19	.	.	.
cord-296347-fanlvxqs	260	1	This	this	DT
cord-296347-fanlvxqs	260	2	IFN	IFN	NNP
cord-296347-fanlvxqs	260	3	-	-	HYPH
cord-296347-fanlvxqs	260	4	g	g	NN
cord-296347-fanlvxqs	260	5	-	-	HYPH
cord-296347-fanlvxqs	260	6	induced	induce	VBN
cord-296347-fanlvxqs	260	7	proteolytic	proteolytic	JJ
cord-296347-fanlvxqs	260	8	cascade	cascade	NN
cord-296347-fanlvxqs	260	9	,	,	,
cord-296347-fanlvxqs	260	10	mediated	mediate	VBN
cord-296347-fanlvxqs	260	11	by	by	IN
cord-296347-fanlvxqs	260	12	immunoproteasomes	immunoproteasome	NNS
cord-296347-fanlvxqs	260	13	and	and	CC
cord-296347-fanlvxqs	260	14	PA28	PA28	NNP
cord-296347-fanlvxqs	260	15	,	,	,
cord-296347-fanlvxqs	260	16	might	may	MD
cord-296347-fanlvxqs	260	17	be	be	VB
cord-296347-fanlvxqs	260	18	induced	induce	VBN
cord-296347-fanlvxqs	260	19	to	to	TO
cord-296347-fanlvxqs	260	20	respond	respond	VB
cord-296347-fanlvxqs	260	21	to	to	IN
cord-296347-fanlvxqs	260	22	a	a	DT
cord-296347-fanlvxqs	260	23	demand	demand	NN
cord-296347-fanlvxqs	260	24	for	for	IN
cord-296347-fanlvxqs	260	25	high	high	JJ
cord-296347-fanlvxqs	260	26	proteasome	proteasome	NN
cord-296347-fanlvxqs	260	27	activity	activity	NN
cord-296347-fanlvxqs	260	28	when	when	WRB
cord-296347-fanlvxqs	260	29	the	the	DT
cord-296347-fanlvxqs	260	30	constitutive	constitutive	JJ
cord-296347-fanlvxqs	260	31	cascade	cascade	NN
cord-296347-fanlvxqs	260	32	is	be	VBZ
cord-296347-fanlvxqs	260	33	no	no	DT
cord-296347-fanlvxqs	260	34	longer	longer	RB
cord-296347-fanlvxqs	260	35	sufficient	sufficient	JJ
cord-296347-fanlvxqs	260	36	,	,	,
cord-296347-fanlvxqs	260	37	altering	alter	VBG
cord-296347-fanlvxqs	260	38	the	the	DT
cord-296347-fanlvxqs	260	39	proteolytic	proteolytic	JJ
cord-296347-fanlvxqs	260	40	activity	activity	NN
cord-296347-fanlvxqs	260	41	of	of	IN
cord-296347-fanlvxqs	260	42	the	the	DT
cord-296347-fanlvxqs	260	43	proteasome	proteasome	NN
cord-296347-fanlvxqs	260	44	for	for	IN
cord-296347-fanlvxqs	260	45	maximal	maximal	JJ
cord-296347-fanlvxqs	260	46	efficiency	efficiency	NN
cord-296347-fanlvxqs	260	47	in	in	IN
cord-296347-fanlvxqs	260	48	production	production	NN
cord-296347-fanlvxqs	260	49	of	of	IN
cord-296347-fanlvxqs	260	50	the	the	DT
cord-296347-fanlvxqs	260	51	class	class	NN
cord-296347-fanlvxqs	260	52	I	-PRON-	PRP
cord-296347-fanlvxqs	260	53	MHC	MHC	NNP
cord-296347-fanlvxqs	260	54	peptide	peptide	NN
cord-296347-fanlvxqs	260	55	repertoire	repertoire	NN
cord-296347-fanlvxqs	260	56	.	.	.
cord-296347-fanlvxqs	261	1	IFN	IFN	NNP
cord-296347-fanlvxqs	261	2	-	-	HYPH
cord-296347-fanlvxqs	261	3	g	g	NN
cord-296347-fanlvxqs	261	4	treatment	treatment	NN
cord-296347-fanlvxqs	261	5	also	also	RB
cord-296347-fanlvxqs	261	6	activates	activate	VBZ
cord-296347-fanlvxqs	261	7	a	a	DT
cord-296347-fanlvxqs	261	8	transcriptional	transcriptional	JJ
cord-296347-fanlvxqs	261	9	program	program	NN
cord-296347-fanlvxqs	261	10	that	that	WDT
cord-296347-fanlvxqs	261	11	increases	increase	VBZ
cord-296347-fanlvxqs	261	12	the	the	DT
cord-296347-fanlvxqs	261	13	synthesis	synthesis	NN
cord-296347-fanlvxqs	261	14	of	of	IN
cord-296347-fanlvxqs	261	15	class	class	NN
cord-296347-fanlvxqs	261	16	I	-PRON-	PRP
cord-296347-fanlvxqs	261	17	MHC	MHC	NNP
cord-296347-fanlvxqs	261	18	molecules	molecule	NNS
cord-296347-fanlvxqs	261	19	themselves	-PRON-	PRP
cord-296347-fanlvxqs	261	20	and	and	CC
cord-296347-fanlvxqs	261	21	that	that	IN
cord-296347-fanlvxqs	261	22	of	of	IN
cord-296347-fanlvxqs	261	23	components	component	NNS
cord-296347-fanlvxqs	261	24	of	of	IN
cord-296347-fanlvxqs	261	25	the	the	DT
cord-296347-fanlvxqs	261	26	peptideloading	peptideloade	VBG
cord-296347-fanlvxqs	261	27	complex	complex	NN
cord-296347-fanlvxqs	261	28	,	,	,
cord-296347-fanlvxqs	261	29	thus	thus	RB
cord-296347-fanlvxqs	261	30	increasing	increase	VBG
cord-296347-fanlvxqs	261	31	cell	cell	NN
cord-296347-fanlvxqs	261	32	surface	surface	NN
cord-296347-fanlvxqs	261	33	presentation	presentation	NN
cord-296347-fanlvxqs	261	34	(	(	-LRB-
cord-296347-fanlvxqs	261	35	Kloetzel	Kloetzel	NNP
cord-296347-fanlvxqs	261	36	,	,	,
cord-296347-fanlvxqs	261	37	2004	2004	CD
cord-296347-fanlvxqs	261	38	;	;	:
cord-296347-fanlvxqs	261	39	Kloetzel	Kloetzel	NNP
cord-296347-fanlvxqs	261	40	and	and	CC
cord-296347-fanlvxqs	261	41	Ossendorp	Ossendorp	NNP
cord-296347-fanlvxqs	261	42	,	,	,
cord-296347-fanlvxqs	261	43	2004	2004	CD
cord-296347-fanlvxqs	261	44	;	;	:
cord-296347-fanlvxqs	261	45	Kruger	Kruger	NNP
cord-296347-fanlvxqs	261	46	et	et	NNP
cord-296347-fanlvxqs	261	47	al	al	NNP
cord-296347-fanlvxqs	261	48	.	.	NNP
cord-296347-fanlvxqs	261	49	,	,	,
cord-296347-fanlvxqs	261	50	2003	2003	CD
cord-296347-fanlvxqs	261	51	;	;	:
cord-296347-fanlvxqs	261	52	Rivett	Rivett	NNP
cord-296347-fanlvxqs	261	53	and	and	CC
cord-296347-fanlvxqs	261	54	Hearn	Hearn	NNP
cord-296347-fanlvxqs	261	55	,	,	,
cord-296347-fanlvxqs	261	56	2004	2004	CD
cord-296347-fanlvxqs	261	57	;	;	:
cord-296347-fanlvxqs	261	58	Van	Van	NNP
cord-296347-fanlvxqs	261	59	den	den	NNP
cord-296347-fanlvxqs	261	60	Eynde	Eynde	NNP
cord-296347-fanlvxqs	261	61	and	and	CC
cord-296347-fanlvxqs	261	62	Morel	Morel	NNP
cord-296347-fanlvxqs	261	63	,	,	,
cord-296347-fanlvxqs	261	64	2001	2001	CD
cord-296347-fanlvxqs	261	65	)	)	-RRB-
cord-296347-fanlvxqs	261	66	.	.	.
cord-296347-fanlvxqs	262	1	Therefore	therefore	RB
cord-296347-fanlvxqs	262	2	,	,	,
cord-296347-fanlvxqs	262	3	even	even	RB
cord-296347-fanlvxqs	262	4	though	though	IN
cord-296347-fanlvxqs	262	5	class	class	NN
cord-296347-fanlvxqs	262	6	I	-PRON-	PRP
cord-296347-fanlvxqs	262	7	MHC	MHC	NNP
cord-296347-fanlvxqs	262	8	presentation	presentation	NN
cord-296347-fanlvxqs	262	9	is	be	VBZ
cord-296347-fanlvxqs	262	10	constitutive	constitutive	JJ
cord-296347-fanlvxqs	262	11	,	,	,
cord-296347-fanlvxqs	262	12	it	-PRON-	PRP
cord-296347-fanlvxqs	262	13	can	can	MD
cord-296347-fanlvxqs	262	14	be	be	VB
cord-296347-fanlvxqs	262	15	modulated	modulate	VBN
cord-296347-fanlvxqs	262	16	in	in	IN
cord-296347-fanlvxqs	262	17	the	the	DT
cord-296347-fanlvxqs	262	18	course	course	NN
cord-296347-fanlvxqs	262	19	of	of	IN
cord-296347-fanlvxqs	262	20	an	an	DT
cord-296347-fanlvxqs	262	21	immune	immune	JJ
cord-296347-fanlvxqs	262	22	response	response	NN
cord-296347-fanlvxqs	262	23	,	,	,
cord-296347-fanlvxqs	262	24	with	with	IN
cord-296347-fanlvxqs	262	25	a	a	DT
cord-296347-fanlvxqs	262	26	proposed	propose	VBN
cord-296347-fanlvxqs	262	27	role	role	NN
cord-296347-fanlvxqs	262	28	in	in	IN
cord-296347-fanlvxqs	262	29	the	the	DT
cord-296347-fanlvxqs	262	30	early	early	JJ
cord-296347-fanlvxqs	262	31	stages	stage	NNS
cord-296347-fanlvxqs	262	32	of	of	IN
cord-296347-fanlvxqs	262	33	a	a	DT
cord-296347-fanlvxqs	262	34	cytotoxic	cytotoxic	JJ
cord-296347-fanlvxqs	262	35	response	response	NN
cord-296347-fanlvxqs	262	36	.	.	.
cord-296347-fanlvxqs	263	1	It	-PRON-	PRP
cord-296347-fanlvxqs	263	2	is	be	VBZ
cord-296347-fanlvxqs	263	3	thus	thus	RB
cord-296347-fanlvxqs	263	4	not	not	RB
cord-296347-fanlvxqs	263	5	surprising	surprising	JJ
cord-296347-fanlvxqs	263	6	that	that	IN
cord-296347-fanlvxqs	263	7	viruses	virus	NNS
cord-296347-fanlvxqs	263	8	have	have	VBP
cord-296347-fanlvxqs	263	9	targeted	target	VBN
cord-296347-fanlvxqs	263	10	the	the	DT
cord-296347-fanlvxqs	263	11	IFN	IFN	NNP
cord-296347-fanlvxqs	263	12	-	-	HYPH
cord-296347-fanlvxqs	263	13	g	g	NNP
cord-296347-fanlvxqs	263	14	signaling	signal	VBG
cord-296347-fanlvxqs	263	15	cascade	cascade	NN
cord-296347-fanlvxqs	263	16	so	so	RB
cord-296347-fanlvxqs	263	17	aggressively	aggressively	RB
cord-296347-fanlvxqs	263	18	(	(	-LRB-
cord-296347-fanlvxqs	263	19	Alcami	Alcami	NNP
cord-296347-fanlvxqs	263	20	and	and	CC
cord-296347-fanlvxqs	263	21	Koszinowski	Koszinowski	NNP
cord-296347-fanlvxqs	263	22	,	,	,
cord-296347-fanlvxqs	263	23	2000	2000	CD
cord-296347-fanlvxqs	263	24	;	;	:
cord-296347-fanlvxqs	264	1	Hengel	Hengel	NNP
cord-296347-fanlvxqs	264	2	et	et	NNP
cord-296347-fanlvxqs	264	3	al	al	NNP
cord-296347-fanlvxqs	264	4	.	.	NNP
cord-296347-fanlvxqs	264	5	,	,	,
cord-296347-fanlvxqs	264	6	2005	2005	CD
cord-296347-fanlvxqs	264	7	;	;	:
cord-296347-fanlvxqs	264	8	Salazar	Salazar	NNP
cord-296347-fanlvxqs	264	9	-	-	HYPH
cord-296347-fanlvxqs	264	10	Mather	Mather	NNP
cord-296347-fanlvxqs	264	11	and	and	CC
cord-296347-fanlvxqs	264	12	Hokeness	Hokeness	NNP
cord-296347-fanlvxqs	264	13	,	,	,
cord-296347-fanlvxqs	264	14	2006	2006	CD
cord-296347-fanlvxqs	264	15	)	)	-RRB-
cord-296347-fanlvxqs	264	16	.	.	.
cord-296347-fanlvxqs	265	1	Although	although	IN
cord-296347-fanlvxqs	265	2	tightly	tightly	RB
cord-296347-fanlvxqs	265	3	controlled	control	VBN
cord-296347-fanlvxqs	265	4	,	,	,
cord-296347-fanlvxqs	265	5	ER	ER	NNP
cord-296347-fanlvxqs	265	6	protein	protein	NN
cord-296347-fanlvxqs	265	7	synthesis	synthesis	NN
cord-296347-fanlvxqs	265	8	is	be	VBZ
cord-296347-fanlvxqs	265	9	not	not	RB
cord-296347-fanlvxqs	265	10	always	always	RB
cord-296347-fanlvxqs	265	11	successful	successful	JJ
cord-296347-fanlvxqs	265	12	.	.	.
cord-296347-fanlvxqs	266	1	Proteins	protein	NNS
cord-296347-fanlvxqs	266	2	may	may	MD
cord-296347-fanlvxqs	266	3	sustain	sustain	VB
cord-296347-fanlvxqs	266	4	damage	damage	NN
cord-296347-fanlvxqs	266	5	or	or	CC
cord-296347-fanlvxqs	266	6	fail	fail	VB
cord-296347-fanlvxqs	266	7	to	to	TO
cord-296347-fanlvxqs	266	8	complete	complete	VB
cord-296347-fanlvxqs	266	9	their	-PRON-	PRP$
cord-296347-fanlvxqs	266	10	synthesis	synthesis	NN
cord-296347-fanlvxqs	266	11	early	early	RB
cord-296347-fanlvxqs	266	12	during	during	IN
cord-296347-fanlvxqs	266	13	biogenesis	biogenesis	NN
cord-296347-fanlvxqs	266	14	,	,	,
cord-296347-fanlvxqs	266	15	or	or	CC
cord-296347-fanlvxqs	266	16	be	be	VB
cord-296347-fanlvxqs	266	17	trapped	trap	VBN
cord-296347-fanlvxqs	266	18	in	in	IN
cord-296347-fanlvxqs	266	19	an	an	DT
cord-296347-fanlvxqs	266	20	irreversible	irreversible	JJ
cord-296347-fanlvxqs	266	21	nonnative	nonnative	JJ
cord-296347-fanlvxqs	266	22	conformation	conformation	NN
cord-296347-fanlvxqs	266	23	,	,	,
cord-296347-fanlvxqs	266	24	or	or	CC
cord-296347-fanlvxqs	266	25	a	a	DT
cord-296347-fanlvxqs	266	26	mutation	mutation	NN
cord-296347-fanlvxqs	266	27	may	may	MD
cord-296347-fanlvxqs	266	28	result	result	VB
cord-296347-fanlvxqs	266	29	in	in	IN
cord-296347-fanlvxqs	266	30	a	a	DT
cord-296347-fanlvxqs	266	31	structural	structural	JJ
cord-296347-fanlvxqs	266	32	alteration	alteration	NN
cord-296347-fanlvxqs	266	33	that	that	WDT
cord-296347-fanlvxqs	266	34	leads	lead	VBZ
cord-296347-fanlvxqs	266	35	to	to	IN
cord-296347-fanlvxqs	266	36	misfolding	misfolde	VBG
cord-296347-fanlvxqs	266	37	,	,	,
cord-296347-fanlvxqs	266	38	as	as	IN
cord-296347-fanlvxqs	266	39	is	be	VBZ
cord-296347-fanlvxqs	266	40	the	the	DT
cord-296347-fanlvxqs	266	41	case	case	NN
cord-296347-fanlvxqs	266	42	for	for	IN
cord-296347-fanlvxqs	266	43	the	the	DT
cord-296347-fanlvxqs	266	44	cystic	cystic	JJ
cord-296347-fanlvxqs	266	45	fibrosis	fibrosis	NN
cord-296347-fanlvxqs	266	46	conductance	conductance	NN
cord-296347-fanlvxqs	266	47	regulator	regulator	NN
cord-296347-fanlvxqs	266	48	(	(	-LRB-
cord-296347-fanlvxqs	266	49	CFTR	CFTR	NNP
cord-296347-fanlvxqs	266	50	)	)	-RRB-
cord-296347-fanlvxqs	267	1	(	(	-LRB-
cord-296347-fanlvxqs	267	2	Jensen	Jensen	NNP
cord-296347-fanlvxqs	267	3	et	et	NNP
cord-296347-fanlvxqs	267	4	al	al	NNP
cord-296347-fanlvxqs	267	5	.	.	NNP
cord-296347-fanlvxqs	267	6	,	,	,
cord-296347-fanlvxqs	267	7	1995	1995	CD
cord-296347-fanlvxqs	268	1	;	;	:
cord-296347-fanlvxqs	268	2	Ward	Ward	NNP
cord-296347-fanlvxqs	268	3	et	et	NNP
cord-296347-fanlvxqs	268	4	al	al	NNP
cord-296347-fanlvxqs	268	5	.	.	NNP
cord-296347-fanlvxqs	268	6	,	,	,
cord-296347-fanlvxqs	268	7	1995	1995	CD
cord-296347-fanlvxqs	268	8	)	)	-RRB-
cord-296347-fanlvxqs	268	9	,	,	,
cord-296347-fanlvxqs	268	10	mutant	mutant	JJ
cord-296347-fanlvxqs	268	11	plasma	plasma	NN
cord-296347-fanlvxqs	268	12	a1-antitrypsin	a1-antitrypsin	NN
cord-296347-fanlvxqs	268	13	(	(	-LRB-
cord-296347-fanlvxqs	268	14	Teckman	Teckman	NNP
cord-296347-fanlvxqs	268	15	and	and	CC
cord-296347-fanlvxqs	268	16	Perlmutter	Perlmutter	NNP
cord-296347-fanlvxqs	268	17	,	,	,
cord-296347-fanlvxqs	268	18	1996	1996	CD
cord-296347-fanlvxqs	268	19	)	)	-RRB-
cord-296347-fanlvxqs	268	20	,	,	,
cord-296347-fanlvxqs	268	21	or	or	CC
cord-296347-fanlvxqs	268	22	tyrosinase	tyrosinase	NN
cord-296347-fanlvxqs	268	23	(	(	-LRB-
cord-296347-fanlvxqs	268	24	Halaban	Halaban	NNP
cord-296347-fanlvxqs	268	25	et	et	NNP
cord-296347-fanlvxqs	268	26	al	al	NNP
cord-296347-fanlvxqs	268	27	.	.	NNP
cord-296347-fanlvxqs	268	28	,	,	,
cord-296347-fanlvxqs	268	29	2000	2000	CD
cord-296347-fanlvxqs	268	30	)	)	-RRB-
cord-296347-fanlvxqs	268	31	.	.	.
cord-296347-fanlvxqs	269	1	They	-PRON-	PRP
cord-296347-fanlvxqs	269	2	may	may	MD
cord-296347-fanlvxqs	269	3	also	also	RB
cord-296347-fanlvxqs	269	4	be	be	VB
cord-296347-fanlvxqs	269	5	expressed	express	VBN
cord-296347-fanlvxqs	269	6	in	in	IN
cord-296347-fanlvxqs	269	7	the	the	DT
cord-296347-fanlvxqs	269	8	absence	absence	NN
cord-296347-fanlvxqs	269	9	of	of	IN
cord-296347-fanlvxqs	269	10	their	-PRON-	PRP$
cord-296347-fanlvxqs	269	11	cognate	cognate	JJ
cord-296347-fanlvxqs	269	12	subunits	subunit	NNS
cord-296347-fanlvxqs	269	13	,	,	,
cord-296347-fanlvxqs	269	14	as	as	IN
cord-296347-fanlvxqs	269	15	is	be	VBZ
cord-296347-fanlvxqs	269	16	the	the	DT
cord-296347-fanlvxqs	269	17	case	case	NN
cord-296347-fanlvxqs	269	18	for	for	IN
cord-296347-fanlvxqs	269	19	unassembled	unassembled	JJ
cord-296347-fanlvxqs	269	20	subunits	subunit	NNS
cord-296347-fanlvxqs	269	21	of	of	IN
cord-296347-fanlvxqs	269	22	TCRa	TCRa	NNP
cord-296347-fanlvxqs	269	23	(	(	-LRB-
cord-296347-fanlvxqs	269	24	Huppa	Huppa	NNP
cord-296347-fanlvxqs	269	25	and	and	CC
cord-296347-fanlvxqs	269	26	Ploegh	Ploegh	NNP
cord-296347-fanlvxqs	269	27	,	,	,
cord-296347-fanlvxqs	269	28	1997	1997	CD
cord-296347-fanlvxqs	269	29	;	;	:
cord-296347-fanlvxqs	269	30	Yang	Yang	NNP
cord-296347-fanlvxqs	269	31	et	et	NNP
cord-296347-fanlvxqs	269	32	al	al	NNP
cord-296347-fanlvxqs	269	33	.	.	NNP
cord-296347-fanlvxqs	269	34	,	,	,
cord-296347-fanlvxqs	269	35	1998	1998	CD
cord-296347-fanlvxqs	269	36	)	)	-RRB-
cord-296347-fanlvxqs	269	37	.	.	.
cord-296347-fanlvxqs	270	1	ER	ER	NNP
cord-296347-fanlvxqs	270	2	quality	quality	NN
cord-296347-fanlvxqs	270	3	control	control	NN
cord-296347-fanlvxqs	270	4	is	be	VBZ
cord-296347-fanlvxqs	270	5	a	a	DT
cord-296347-fanlvxqs	270	6	homeostatic	homeostatic	JJ
cord-296347-fanlvxqs	270	7	process	process	NN
cord-296347-fanlvxqs	270	8	that	that	WDT
cord-296347-fanlvxqs	270	9	involves	involve	VBZ
cord-296347-fanlvxqs	270	10	an	an	DT
cord-296347-fanlvxqs	270	11	elaborate	elaborate	JJ
cord-296347-fanlvxqs	270	12	machinery	machinery	NN
cord-296347-fanlvxqs	270	13	that	that	WDT
cord-296347-fanlvxqs	270	14	recognizes	recognize	VBZ
cord-296347-fanlvxqs	270	15	and	and	CC
cord-296347-fanlvxqs	270	16	retains	retain	VBZ
cord-296347-fanlvxqs	270	17	newly	newly	RB
cord-296347-fanlvxqs	270	18	synthesized	synthesize	VBN
cord-296347-fanlvxqs	270	19	misfolded	misfolde	VBN
cord-296347-fanlvxqs	270	20	or	or	CC
cord-296347-fanlvxqs	270	21	misassembled	misassemble	VBN
cord-296347-fanlvxqs	270	22	proteins	protein	NNS
cord-296347-fanlvxqs	270	23	and	and	CC
cord-296347-fanlvxqs	270	24	targets	target	NNS
cord-296347-fanlvxqs	270	25	many	many	JJ
cord-296347-fanlvxqs	270	26	of	of	IN
cord-296347-fanlvxqs	270	27	them	-PRON-	PRP
cord-296347-fanlvxqs	270	28	for	for	IN
cord-296347-fanlvxqs	270	29	degradation	degradation	NN
cord-296347-fanlvxqs	270	30	by	by	IN
cord-296347-fanlvxqs	270	31	the	the	DT
cord-296347-fanlvxqs	270	32	Ub	Ub	NNP
cord-296347-fanlvxqs	270	33	-	-	HYPH
cord-296347-fanlvxqs	270	34	proteasome	proteasome	NN
cord-296347-fanlvxqs	270	35	system	system	NN
cord-296347-fanlvxqs	270	36	(	(	-LRB-
cord-296347-fanlvxqs	270	37	Ellgaard	Ellgaard	NNP
cord-296347-fanlvxqs	270	38	and	and	CC
cord-296347-fanlvxqs	270	39	Helenius	Helenius	NNP
cord-296347-fanlvxqs	270	40	,	,	,
cord-296347-fanlvxqs	270	41	2003	2003	CD
cord-296347-fanlvxqs	270	42	)	)	-RRB-
cord-296347-fanlvxqs	270	43	.	.	.
cord-296347-fanlvxqs	271	1	This	this	DT
cord-296347-fanlvxqs	271	2	mode	mode	NN
cord-296347-fanlvxqs	271	3	of	of	IN
cord-296347-fanlvxqs	271	4	degradation	degradation	NN
cord-296347-fanlvxqs	271	5	therefore	therefore	RB
cord-296347-fanlvxqs	271	6	samples	sample	VBZ
cord-296347-fanlvxqs	271	7	sets	set	NNS
cord-296347-fanlvxqs	271	8	of	of	IN
cord-296347-fanlvxqs	271	9	proteins	protein	NNS
cord-296347-fanlvxqs	271	10	otherwise	otherwise	RB
cord-296347-fanlvxqs	271	11	targeted	target	VBN
cord-296347-fanlvxqs	271	12	to	to	IN
cord-296347-fanlvxqs	271	13	extracellular	extracellular	JJ
cord-296347-fanlvxqs	271	14	space	space	NN
cord-296347-fanlvxqs	271	15	,	,	,
cord-296347-fanlvxqs	271	16	where	where	WRB
cord-296347-fanlvxqs	271	17	the	the	DT
cord-296347-fanlvxqs	271	18	degradation	degradation	NN
cord-296347-fanlvxqs	271	19	products	product	NNS
cord-296347-fanlvxqs	271	20	are	be	VBP
cord-296347-fanlvxqs	271	21	available	available	JJ
cord-296347-fanlvxqs	271	22	as	as	IN
cord-296347-fanlvxqs	271	23	peptide	peptide	NN
cord-296347-fanlvxqs	271	24	ligands	ligand	NNS
cord-296347-fanlvxqs	271	25	for	for	IN
cord-296347-fanlvxqs	271	26	class	class	NN
cord-296347-fanlvxqs	271	27	II	II	NNP
cord-296347-fanlvxqs	271	28	MHC	MHC	NNP
cord-296347-fanlvxqs	271	29	products	product	NNS
cord-296347-fanlvxqs	271	30	.	.	.
cord-296347-fanlvxqs	272	1	In	in	IN
cord-296347-fanlvxqs	272	2	addition	addition	NN
cord-296347-fanlvxqs	272	3	to	to	IN
cord-296347-fanlvxqs	272	4	its	-PRON-	PRP$
cord-296347-fanlvxqs	272	5	role	role	NN
cord-296347-fanlvxqs	272	6	in	in	IN
cord-296347-fanlvxqs	272	7	ER	ER	NNP
cord-296347-fanlvxqs	272	8	quality	quality	NN
cord-296347-fanlvxqs	272	9	control	control	NN
cord-296347-fanlvxqs	272	10	,	,	,
cord-296347-fanlvxqs	272	11	this	this	DT
cord-296347-fanlvxqs	272	12	ER	ER	NNP
cord-296347-fanlvxqs	272	13	-	-	HYPH
cord-296347-fanlvxqs	272	14	associated	associate	VBN
cord-296347-fanlvxqs	272	15	degradation	degradation	NN
cord-296347-fanlvxqs	272	16	(	(	-LRB-
cord-296347-fanlvxqs	272	17	ERAD	ERAD	NNP
cord-296347-fanlvxqs	272	18	)	)	-RRB-
cord-296347-fanlvxqs	272	19	can	can	MD
cord-296347-fanlvxqs	272	20	also	also	RB
cord-296347-fanlvxqs	272	21	be	be	VB
cord-296347-fanlvxqs	272	22	employed	employ	VBN
cord-296347-fanlvxqs	272	23	in	in	IN
cord-296347-fanlvxqs	272	24	the	the	DT
cord-296347-fanlvxqs	272	25	physiological	physiological	JJ
cord-296347-fanlvxqs	272	26	regulated	regulated	JJ
cord-296347-fanlvxqs	272	27	proteolysis	proteolysis	NN
cord-296347-fanlvxqs	272	28	of	of	IN
cord-296347-fanlvxqs	272	29	normal	normal	JJ
cord-296347-fanlvxqs	272	30	ER	ER	NNP
cord-296347-fanlvxqs	272	31	proteins	protein	NNS
cord-296347-fanlvxqs	272	32	whose	whose	WP$
cord-296347-fanlvxqs	272	33	degradation	degradation	NN
cord-296347-fanlvxqs	272	34	is	be	VBZ
cord-296347-fanlvxqs	272	35	subject	subject	JJ
cord-296347-fanlvxqs	272	36	to	to	IN
cord-296347-fanlvxqs	272	37	metabolic	metabolic	JJ
cord-296347-fanlvxqs	272	38	cues	cue	NNS
cord-296347-fanlvxqs	272	39	,	,	,
cord-296347-fanlvxqs	272	40	such	such	JJ
cord-296347-fanlvxqs	272	41	as	as	IN
cord-296347-fanlvxqs	272	42	hydroxymethylglutaryl	hydroxymethylglutaryl	NNP
cord-296347-fanlvxqs	272	43	-	-	HYPH
cord-296347-fanlvxqs	272	44	coenzyme	coenzyme	VBZ
cord-296347-fanlvxqs	272	45	A	a	DT
cord-296347-fanlvxqs	272	46	reductase	reductase	NN
cord-296347-fanlvxqs	272	47	(	(	-LRB-
cord-296347-fanlvxqs	272	48	HMGR	HMGR	NNP
cord-296347-fanlvxqs	272	49	)	)	-RRB-
cord-296347-fanlvxqs	273	1	(	(	-LRB-
cord-296347-fanlvxqs	273	2	Hampton	Hampton	NNP
cord-296347-fanlvxqs	273	3	,	,	,
cord-296347-fanlvxqs	273	4	2002	2002	CD
cord-296347-fanlvxqs	273	5	;	;	:
cord-296347-fanlvxqs	273	6	Hampton	Hampton	NNP
cord-296347-fanlvxqs	273	7	and	and	CC
cord-296347-fanlvxqs	273	8	Bhakta	Bhakta	NNP
cord-296347-fanlvxqs	273	9	,	,	,
cord-296347-fanlvxqs	273	10	1997	1997	CD
cord-296347-fanlvxqs	273	11	)	)	-RRB-
cord-296347-fanlvxqs	273	12	.	.	.
cord-296347-fanlvxqs	274	1	A	a	DT
cord-296347-fanlvxqs	274	2	feature	feature	NN
cord-296347-fanlvxqs	274	3	of	of	IN
cord-296347-fanlvxqs	274	4	this	this	DT
cord-296347-fanlvxqs	274	5	ER	ER	NNP
cord-296347-fanlvxqs	274	6	-	-	HYPH
cord-296347-fanlvxqs	274	7	associated	associate	VBN
cord-296347-fanlvxqs	274	8	protein	protein	NN
cord-296347-fanlvxqs	274	9	degradation	degradation	NN
cord-296347-fanlvxqs	274	10	is	be	VBZ
cord-296347-fanlvxqs	274	11	the	the	DT
cord-296347-fanlvxqs	274	12	spatial	spatial	JJ
cord-296347-fanlvxqs	274	13	separation	separation	NN
cord-296347-fanlvxqs	274	14	between	between	IN
cord-296347-fanlvxqs	274	15	targeting	targeting	NN
cord-296347-fanlvxqs	274	16	of	of	IN
cord-296347-fanlvxqs	274	17	substrates	substrate	NNS
cord-296347-fanlvxqs	274	18	and	and	CC
cord-296347-fanlvxqs	274	19	their	-PRON-	PRP$
cord-296347-fanlvxqs	274	20	proteolysis	proteolysis	NN
cord-296347-fanlvxqs	274	21	,	,	,
cord-296347-fanlvxqs	274	22	which	which	WDT
cord-296347-fanlvxqs	274	23	requires	require	VBZ
cord-296347-fanlvxqs	274	24	substrate	substrate	JJ
cord-296347-fanlvxqs	274	25	export	export	NN
cord-296347-fanlvxqs	274	26	from	from	IN
cord-296347-fanlvxqs	274	27	the	the	DT
cord-296347-fanlvxqs	274	28	ER	ER	NNP
cord-296347-fanlvxqs	274	29	lumen	lumen	NN
cord-296347-fanlvxqs	274	30	or	or	CC
cord-296347-fanlvxqs	274	31	membrane	membrane	NN
cord-296347-fanlvxqs	274	32	to	to	IN
cord-296347-fanlvxqs	274	33	the	the	DT
cord-296347-fanlvxqs	274	34	cytoplasm	cytoplasm	NN
cord-296347-fanlvxqs	274	35	by	by	IN
cord-296347-fanlvxqs	274	36	a	a	DT
cord-296347-fanlvxqs	274	37	process	process	NN
cord-296347-fanlvxqs	274	38	termed	term	VBN
cord-296347-fanlvxqs	274	39	dislocation	dislocation	NN
cord-296347-fanlvxqs	274	40	(	(	-LRB-
cord-296347-fanlvxqs	274	41	also	also	RB
cord-296347-fanlvxqs	274	42	called	call	VBN
cord-296347-fanlvxqs	274	43	retrograde	retrograde	JJ
cord-296347-fanlvxqs	274	44	translocation	translocation	NN
cord-296347-fanlvxqs	274	45	or	or	CC
cord-296347-fanlvxqs	274	46	retrotranslocation	retrotranslocation	NN
cord-296347-fanlvxqs	274	47	)	)	-RRB-
cord-296347-fanlvxqs	275	1	(	(	-LRB-
cord-296347-fanlvxqs	275	2	Werner	Werner	NNP
cord-296347-fanlvxqs	275	3	et	et	NNP
cord-296347-fanlvxqs	275	4	al	al	NNP
cord-296347-fanlvxqs	275	5	.	.	NNP
cord-296347-fanlvxqs	275	6	,	,	,
cord-296347-fanlvxqs	275	7	1996	1996	CD
cord-296347-fanlvxqs	275	8	)	)	-RRB-
cord-296347-fanlvxqs	275	9	.	.	.
cord-296347-fanlvxqs	276	1	Dislocation	dislocation	NN
cord-296347-fanlvxqs	276	2	is	be	VBZ
cord-296347-fanlvxqs	276	3	a	a	DT
cord-296347-fanlvxqs	276	4	complicated	complicated	JJ
cord-296347-fanlvxqs	276	5	multistep	multistep	JJ
cord-296347-fanlvxqs	276	6	process	process	NN
cord-296347-fanlvxqs	276	7	that	that	WDT
cord-296347-fanlvxqs	276	8	involves	involve	VBZ
cord-296347-fanlvxqs	276	9	substrate	substrate	JJ
cord-296347-fanlvxqs	276	10	recognition	recognition	NN
cord-296347-fanlvxqs	276	11	,	,	,
cord-296347-fanlvxqs	276	12	targeting	target	VBG
cord-296347-fanlvxqs	276	13	for	for	IN
cord-296347-fanlvxqs	276	14	dislocation	dislocation	NN
cord-296347-fanlvxqs	276	15	,	,	,
cord-296347-fanlvxqs	276	16	removal	removal	NN
cord-296347-fanlvxqs	276	17	from	from	IN
cord-296347-fanlvxqs	276	18	the	the	DT
cord-296347-fanlvxqs	276	19	ER	ER	NNP
cord-296347-fanlvxqs	276	20	membrane	membrane	NN
cord-296347-fanlvxqs	276	21	,	,	,
cord-296347-fanlvxqs	276	22	deglycosylation	deglycosylation	NN
cord-296347-fanlvxqs	276	23	,	,	,
cord-296347-fanlvxqs	276	24	ubiquitination	ubiquitination	NN
cord-296347-fanlvxqs	276	25	,	,	,
cord-296347-fanlvxqs	276	26	and	and	CC
cord-296347-fanlvxqs	276	27	finally	finally	RB
cord-296347-fanlvxqs	276	28	proteolysis	proteolysis	NN
cord-296347-fanlvxqs	276	29	(	(	-LRB-
cord-296347-fanlvxqs	276	30	Kostova	Kostova	NNP
cord-296347-fanlvxqs	276	31	and	and	CC
cord-296347-fanlvxqs	276	32	Wolf	Wolf	NNP
cord-296347-fanlvxqs	276	33	,	,	,
cord-296347-fanlvxqs	276	34	2003	2003	CD
cord-296347-fanlvxqs	276	35	;	;	:
cord-296347-fanlvxqs	276	36	Meusser	Meusser	NNP
cord-296347-fanlvxqs	276	37	et	et	NNP
cord-296347-fanlvxqs	276	38	al	al	NNP
cord-296347-fanlvxqs	276	39	.	.	NNP
cord-296347-fanlvxqs	276	40	,	,	,
cord-296347-fanlvxqs	276	41	2005	2005	CD
cord-296347-fanlvxqs	276	42	;	;	:
cord-296347-fanlvxqs	276	43	Romisch	Romisch	NNP
cord-296347-fanlvxqs	276	44	,	,	,
cord-296347-fanlvxqs	276	45	2005	2005	CD
cord-296347-fanlvxqs	276	46	)	)	-RRB-
cord-296347-fanlvxqs	276	47	.	.	.
cord-296347-fanlvxqs	277	1	The	the	DT
cord-296347-fanlvxqs	277	2	proteasome	proteasome	NN
cord-296347-fanlvxqs	277	3	is	be	VBZ
cord-296347-fanlvxqs	277	4	usually	usually	RB
cord-296347-fanlvxqs	277	5	considered	consider	VBN
cord-296347-fanlvxqs	277	6	to	to	TO
cord-296347-fanlvxqs	277	7	be	be	VB
cord-296347-fanlvxqs	277	8	a	a	DT
cord-296347-fanlvxqs	277	9	nonselective	nonselective	JJ
cord-296347-fanlvxqs	277	10	degradation	degradation	NN
cord-296347-fanlvxqs	277	11	apparatus	apparatus	NN
cord-296347-fanlvxqs	277	12	,	,	,
cord-296347-fanlvxqs	277	13	with	with	IN
cord-296347-fanlvxqs	277	14	selection	selection	NN
cord-296347-fanlvxqs	277	15	of	of	IN
cord-296347-fanlvxqs	277	16	ERAD	ERAD	NNP
cord-296347-fanlvxqs	277	17	substrates	substrate	NNS
cord-296347-fanlvxqs	277	18	being	be	VBG
cord-296347-fanlvxqs	277	19	mediated	mediate	VBN
cord-296347-fanlvxqs	277	20	mostly	mostly	RB
cord-296347-fanlvxqs	277	21	by	by	IN
cord-296347-fanlvxqs	277	22	the	the	DT
cord-296347-fanlvxqs	277	23	Ub	Ub	NNP
cord-296347-fanlvxqs	277	24	ligases	ligase	NNS
cord-296347-fanlvxqs	277	25	.	.	.
cord-296347-fanlvxqs	278	1	However	however	RB
cord-296347-fanlvxqs	278	2	,	,	,
cord-296347-fanlvxqs	278	3	the	the	DT
cord-296347-fanlvxqs	278	4	ER	ER	NNP
cord-296347-fanlvxqs	278	5	quality	quality	NN
cord-296347-fanlvxqs	278	6	control	control	NN
cord-296347-fanlvxqs	278	7	E3	e3	NN
cord-296347-fanlvxqs	278	8	enzymes	enzyme	NNS
cord-296347-fanlvxqs	278	9	are	be	VBP
cord-296347-fanlvxqs	278	10	mostly	mostly	RB
cord-296347-fanlvxqs	278	11	cytosolic	cytosolic	JJ
cord-296347-fanlvxqs	278	12	or	or	CC
cord-296347-fanlvxqs	278	13	membrane	membrane	NN
cord-296347-fanlvxqs	278	14	-	-	HYPH
cord-296347-fanlvxqs	278	15	associated	associate	VBN
cord-296347-fanlvxqs	278	16	and	and	CC
cord-296347-fanlvxqs	278	17	thus	thus	RB
cord-296347-fanlvxqs	278	18	are	be	VBP
cord-296347-fanlvxqs	278	19	separated	separate	VBN
cord-296347-fanlvxqs	278	20	from	from	IN
cord-296347-fanlvxqs	278	21	their	-PRON-	PRP$
cord-296347-fanlvxqs	278	22	substrates	substrate	NNS
cord-296347-fanlvxqs	278	23	at	at	IN
cord-296347-fanlvxqs	278	24	least	least	JJS
cord-296347-fanlvxqs	278	25	by	by	IN
cord-296347-fanlvxqs	278	26	the	the	DT
cord-296347-fanlvxqs	278	27	ER	ER	NNP
cord-296347-fanlvxqs	278	28	membrane	membrane	NN
cord-296347-fanlvxqs	278	29	.	.	.
cord-296347-fanlvxqs	279	1	This	this	DT
cord-296347-fanlvxqs	279	2	invokes	invoke	VBZ
cord-296347-fanlvxqs	279	3	the	the	DT
cord-296347-fanlvxqs	279	4	existence	existence	NN
cord-296347-fanlvxqs	279	5	of	of	IN
cord-296347-fanlvxqs	279	6	mechanisms	mechanism	NNS
cord-296347-fanlvxqs	279	7	,	,	,
cord-296347-fanlvxqs	279	8	present	present	JJ
cord-296347-fanlvxqs	279	9	in	in	IN
cord-296347-fanlvxqs	279	10	E3	E3	NNP
cord-296347-fanlvxqs	279	11	ligases	ligase	NNS
cord-296347-fanlvxqs	279	12	themselves	-PRON-	PRP
cord-296347-fanlvxqs	279	13	or	or	CC
cord-296347-fanlvxqs	279	14	in	in	IN
cord-296347-fanlvxqs	279	15	upstream	upstream	JJ
cord-296347-fanlvxqs	279	16	factors	factor	NNS
cord-296347-fanlvxqs	279	17	,	,	,
cord-296347-fanlvxqs	279	18	which	which	WDT
cord-296347-fanlvxqs	279	19	facilitate	facilitate	VBP
cord-296347-fanlvxqs	279	20	coupling	coupling	NN
cord-296347-fanlvxqs	279	21	of	of	IN
cord-296347-fanlvxqs	279	22	ERAD	ERAD	NNP
cord-296347-fanlvxqs	279	23	substrate	substrate	NN
cord-296347-fanlvxqs	279	24	recognition	recognition	NN
cord-296347-fanlvxqs	279	25	to	to	IN
cord-296347-fanlvxqs	279	26	ubiquitination	ubiquitination	NN
cord-296347-fanlvxqs	279	27	by	by	IN
cord-296347-fanlvxqs	279	28	E3	E3	NNP
cord-296347-fanlvxqs	279	29	ligases	ligase	NNS
cord-296347-fanlvxqs	279	30	in	in	IN
cord-296347-fanlvxqs	279	31	the	the	DT
cord-296347-fanlvxqs	279	32	cytoplasm	cytoplasm	NN
cord-296347-fanlvxqs	279	33	.	.	.
cord-296347-fanlvxqs	280	1	Owing	owe	VBG
cord-296347-fanlvxqs	280	2	to	to	IN
cord-296347-fanlvxqs	280	3	the	the	DT
cord-296347-fanlvxqs	280	4	extremely	extremely	RB
cord-296347-fanlvxqs	280	5	diverse	diverse	JJ
cord-296347-fanlvxqs	280	6	nature	nature	NN
cord-296347-fanlvxqs	280	7	of	of	IN
cord-296347-fanlvxqs	280	8	proteins	protein	NNS
cord-296347-fanlvxqs	280	9	that	that	WDT
cord-296347-fanlvxqs	280	10	must	must	MD
cord-296347-fanlvxqs	280	11	be	be	VB
cord-296347-fanlvxqs	280	12	examined	examine	VBN
cord-296347-fanlvxqs	280	13	by	by	IN
cord-296347-fanlvxqs	280	14	the	the	DT
cord-296347-fanlvxqs	280	15	ER	ER	NNP
cord-296347-fanlvxqs	280	16	quality	quality	NN
cord-296347-fanlvxqs	280	17	control	control	NN
cord-296347-fanlvxqs	280	18	machinery	machinery	NN
cord-296347-fanlvxqs	280	19	,	,	,
cord-296347-fanlvxqs	280	20	a	a	DT
cord-296347-fanlvxqs	280	21	unifying	unifying	JJ
cord-296347-fanlvxqs	280	22	model	model	NN
cord-296347-fanlvxqs	280	23	for	for	IN
cord-296347-fanlvxqs	280	24	how	how	WRB
cord-296347-fanlvxqs	280	25	recognition	recognition	NN
cord-296347-fanlvxqs	280	26	of	of	IN
cord-296347-fanlvxqs	280	27	ERAD	ERAD	NNP
cord-296347-fanlvxqs	280	28	substrates	substrate	NNS
cord-296347-fanlvxqs	280	29	takes	take	VBZ
cord-296347-fanlvxqs	280	30	place	place	NN
cord-296347-fanlvxqs	280	31	remains	remain	VBZ
cord-296347-fanlvxqs	280	32	intractable	intractable	JJ
cord-296347-fanlvxqs	280	33	.	.	.
cord-296347-fanlvxqs	281	1	Nonetheless	nonetheless	RB
cord-296347-fanlvxqs	281	2	,	,	,
cord-296347-fanlvxqs	281	3	misfolded	misfolde	VBN
cord-296347-fanlvxqs	281	4	proteins	protein	NNS
cord-296347-fanlvxqs	281	5	cleared	clear	VBN
cord-296347-fanlvxqs	281	6	from	from	IN
cord-296347-fanlvxqs	281	7	the	the	DT
cord-296347-fanlvxqs	281	8	ER	ER	NNP
cord-296347-fanlvxqs	281	9	enter	enter	VB
cord-296347-fanlvxqs	281	10	the	the	DT
cord-296347-fanlvxqs	281	11	class	class	NN
cord-296347-fanlvxqs	281	12	I	-PRON-	PRP
cord-296347-fanlvxqs	281	13	MHC	MHC	NNP
cord-296347-fanlvxqs	281	14	-	-	HYPH
cord-296347-fanlvxqs	281	15	processing	process	VBG
cord-296347-fanlvxqs	281	16	pathway	pathway	NN
cord-296347-fanlvxqs	281	17	,	,	,
cord-296347-fanlvxqs	281	18	and	and	CC
cord-296347-fanlvxqs	281	19	hence	hence	RB
cord-296347-fanlvxqs	281	20	this	this	DT
cord-296347-fanlvxqs	281	21	route	route	NN
cord-296347-fanlvxqs	281	22	of	of	IN
cord-296347-fanlvxqs	281	23	degradation	degradation	NN
cord-296347-fanlvxqs	281	24	is	be	VBZ
cord-296347-fanlvxqs	281	25	an	an	DT
cord-296347-fanlvxqs	281	26	important	important	JJ
cord-296347-fanlvxqs	281	27	aspect	aspect	NN
cord-296347-fanlvxqs	281	28	of	of	IN
cord-296347-fanlvxqs	281	29	the	the	DT
cord-296347-fanlvxqs	281	30	generation	generation	NN
cord-296347-fanlvxqs	281	31	of	of	IN
cord-296347-fanlvxqs	281	32	class	class	NN
cord-296347-fanlvxqs	281	33	I	-PRON-	PRP
cord-296347-fanlvxqs	281	34	MHC	MHC	NNP
cord-296347-fanlvxqs	281	35	epitopes	epitope	NNS
cord-296347-fanlvxqs	281	36	.	.	.
cord-296347-fanlvxqs	282	1	Instead	instead	RB
cord-296347-fanlvxqs	282	2	,	,	,
cord-296347-fanlvxqs	282	3	ERAD	ERAD	NNP
cord-296347-fanlvxqs	282	4	is	be	VBZ
cord-296347-fanlvxqs	282	5	likely	likely	JJ
cord-296347-fanlvxqs	282	6	to	to	TO
cord-296347-fanlvxqs	282	7	be	be	VB
cord-296347-fanlvxqs	282	8	custom	custom	NN
cord-296347-fanlvxqs	282	9	-	-	HYPH
cord-296347-fanlvxqs	282	10	fitted	fit	VBN
cord-296347-fanlvxqs	282	11	to	to	IN
cord-296347-fanlvxqs	282	12	the	the	DT
cord-296347-fanlvxqs	282	13	client	client	NN
cord-296347-fanlvxqs	282	14	protein	protein	NN
cord-296347-fanlvxqs	282	15	in	in	IN
cord-296347-fanlvxqs	282	16	question	question	NN
cord-296347-fanlvxqs	282	17	.	.	.
cord-296347-fanlvxqs	283	1	For	for	IN
cord-296347-fanlvxqs	283	2	glycoproteins	glycoprotein	NNS
cord-296347-fanlvxqs	283	3	,	,	,
cord-296347-fanlvxqs	283	4	a	a	DT
cord-296347-fanlvxqs	283	5	possible	possible	JJ
cord-296347-fanlvxqs	283	6	mechanism	mechanism	NN
cord-296347-fanlvxqs	283	7	is	be	VBZ
cord-296347-fanlvxqs	283	8	the	the	DT
cord-296347-fanlvxqs	283	9	recognition	recognition	NN
cord-296347-fanlvxqs	283	10	of	of	IN
cord-296347-fanlvxqs	283	11	terminally	terminally	RB
cord-296347-fanlvxqs	283	12	misfolded	misfolde	VBN
cord-296347-fanlvxqs	283	13	proteins	protein	NNS
cord-296347-fanlvxqs	283	14	by	by	IN
cord-296347-fanlvxqs	283	15	the	the	DT
cord-296347-fanlvxqs	283	16	calnexin	calnexin	NNP
cord-296347-fanlvxqs	283	17	/	/	SYM
cord-296347-fanlvxqs	283	18	calreticulin	calreticulin	NNP
cord-296347-fanlvxqs	283	19	(	(	-LRB-
cord-296347-fanlvxqs	283	20	CNX	CNX	NNP
cord-296347-fanlvxqs	283	21	/	/	SYM
cord-296347-fanlvxqs	283	22	CRT	CRT	NNP
cord-296347-fanlvxqs	283	23	)	)	-RRB-
cord-296347-fanlvxqs	283	24	lectin	lectin	NN
cord-296347-fanlvxqs	283	25	-	-	HYPH
cord-296347-fanlvxqs	283	26	type	type	NN
cord-296347-fanlvxqs	283	27	chaperones	chaperone	NNS
cord-296347-fanlvxqs	283	28	,	,	,
cord-296347-fanlvxqs	283	29	which	which	WDT
cord-296347-fanlvxqs	283	30	retain	retain	VBP
cord-296347-fanlvxqs	283	31	immature	immature	JJ
cord-296347-fanlvxqs	283	32	glycoproteins	glycoprotein	NNS
cord-296347-fanlvxqs	283	33	in	in	IN
cord-296347-fanlvxqs	283	34	the	the	DT
cord-296347-fanlvxqs	283	35	ER	ER	NNP
cord-296347-fanlvxqs	283	36	until	until	IN
cord-296347-fanlvxqs	283	37	productive	productive	JJ
cord-296347-fanlvxqs	283	38	folding	folding	NN
cord-296347-fanlvxqs	283	39	takes	take	VBZ
cord-296347-fanlvxqs	283	40	place	place	NN
cord-296347-fanlvxqs	284	1	(	(	-LRB-
cord-296347-fanlvxqs	284	2	Ellgaard	Ellgaard	NNP
cord-296347-fanlvxqs	284	3	and	and	CC
cord-296347-fanlvxqs	284	4	Helenius	Helenius	NNP
cord-296347-fanlvxqs	284	5	,	,	,
cord-296347-fanlvxqs	284	6	2003	2003	CD
cord-296347-fanlvxqs	284	7	;	;	:
cord-296347-fanlvxqs	284	8	Hammond	Hammond	NNP
cord-296347-fanlvxqs	284	9	,	,	,
cord-296347-fanlvxqs	284	10	1994	1994	CD
cord-296347-fanlvxqs	284	11	;	;	:
cord-296347-fanlvxqs	284	12	Helenius	Helenius	NNP
cord-296347-fanlvxqs	284	13	and	and	CC
cord-296347-fanlvxqs	284	14	Aebi	Aebi	NNP
cord-296347-fanlvxqs	284	15	,	,	,
cord-296347-fanlvxqs	284	16	2004	2004	CD
cord-296347-fanlvxqs	284	17	)	)	-RRB-
cord-296347-fanlvxqs	284	18	.	.	.
cord-296347-fanlvxqs	285	1	Terminally	terminally	RB
cord-296347-fanlvxqs	285	2	misfolded	misfolde	VBN
cord-296347-fanlvxqs	285	3	proteins-	proteins-	XX
cord-296347-fanlvxqs	286	1	that	that	DT
cord-296347-fanlvxqs	286	2	is	is	RB
cord-296347-fanlvxqs	286	3	,	,	,
cord-296347-fanlvxqs	286	4	proteins	protein	NNS
cord-296347-fanlvxqs	286	5	that	that	IN
cord-296347-fanlvxqs	286	6	after	after	IN
cord-296347-fanlvxqs	286	7	extensive	extensive	JJ
cord-296347-fanlvxqs	286	8	CXN	CXN	NNP
cord-296347-fanlvxqs	286	9	/	/	SYM
cord-296347-fanlvxqs	286	10	CRT	CRT	NNP
cord-296347-fanlvxqs	286	11	cycle	cycle	NN
cord-296347-fanlvxqs	286	12	folding	folding	NN
cord-296347-fanlvxqs	286	13	attempts	attempt	NNS
cord-296347-fanlvxqs	286	14	still	still	RB
cord-296347-fanlvxqs	286	15	fail	fail	VBP
cord-296347-fanlvxqs	286	16	to	to	TO
cord-296347-fanlvxqs	286	17	acquire	acquire	VB
cord-296347-fanlvxqs	286	18	their	-PRON-	PRP$
cord-296347-fanlvxqs	286	19	native	native	JJ
cord-296347-fanlvxqs	286	20	conformation	conformation	NN
cord-296347-fanlvxqs	287	1	-are	-are	:
cord-296347-fanlvxqs	287	2	trimmed	trim	VBN
cord-296347-fanlvxqs	287	3	by	by	IN
cord-296347-fanlvxqs	287	4	ER	ER	NNP
cord-296347-fanlvxqs	287	5	mannosidase	mannosidase	NN
cord-296347-fanlvxqs	287	6	I	I	NNP
cord-296347-fanlvxqs	287	7	,	,	,
cord-296347-fanlvxqs	287	8	leading	lead	VBG
cord-296347-fanlvxqs	287	9	to	to	IN
cord-296347-fanlvxqs	287	10	recognition	recognition	NN
cord-296347-fanlvxqs	287	11	by	by	IN
cord-296347-fanlvxqs	287	12	ER	ER	NNP
cord-296347-fanlvxqs	287	13	degradation	degradation	NN
cord-296347-fanlvxqs	287	14	-	-	HYPH
cord-296347-fanlvxqs	287	15	enhancing	enhance	VBG
cord-296347-fanlvxqs	287	16	alpha	alpha	NN
cord-296347-fanlvxqs	287	17	-	-	HYPH
cord-296347-fanlvxqs	287	18	mannosidase	mannosidase	NN
cord-296347-fanlvxqs	287	19	-	-	HYPH
cord-296347-fanlvxqs	287	20	like	like	JJ
cord-296347-fanlvxqs	287	21	protein	protein	NN
cord-296347-fanlvxqs	287	22	(	(	-LRB-
cord-296347-fanlvxqs	287	23	EDEM	EDEM	NNP
cord-296347-fanlvxqs	287	24	)	)	-RRB-
cord-296347-fanlvxqs	287	25	,	,	,
cord-296347-fanlvxqs	287	26	which	which	WDT
cord-296347-fanlvxqs	287	27	presumably	presumably	RB
cord-296347-fanlvxqs	287	28	targets	target	VBZ
cord-296347-fanlvxqs	287	29	them	-PRON-	PRP
cord-296347-fanlvxqs	287	30	for	for	IN
cord-296347-fanlvxqs	287	31	degradation	degradation	NN
cord-296347-fanlvxqs	287	32	(	(	-LRB-
cord-296347-fanlvxqs	287	33	Eriksson	Eriksson	NNP
cord-296347-fanlvxqs	287	34	et	et	NNP
cord-296347-fanlvxqs	287	35	al	al	NNP
cord-296347-fanlvxqs	287	36	.	.	NNP
cord-296347-fanlvxqs	287	37	,	,	,
cord-296347-fanlvxqs	287	38	2004	2004	CD
cord-296347-fanlvxqs	287	39	;	;	:
cord-296347-fanlvxqs	287	40	Jakob	Jakob	NNP
cord-296347-fanlvxqs	287	41	et	et	NNP
cord-296347-fanlvxqs	287	42	al	al	NNP
cord-296347-fanlvxqs	287	43	.	.	NNP
cord-296347-fanlvxqs	287	44	,	,	,
cord-296347-fanlvxqs	287	45	2001	2001	CD
cord-296347-fanlvxqs	287	46	;	;	:
cord-296347-fanlvxqs	287	47	Molinari	Molinari	NNP
cord-296347-fanlvxqs	287	48	et	et	NNP
cord-296347-fanlvxqs	287	49	al	al	NNP
cord-296347-fanlvxqs	287	50	.	.	NNP
cord-296347-fanlvxqs	287	51	,	,	,
cord-296347-fanlvxqs	287	52	2003	2003	CD
cord-296347-fanlvxqs	287	53	)	)	-RRB-
cord-296347-fanlvxqs	287	54	.	.	.
cord-296347-fanlvxqs	288	1	Most	Most	JJS
cord-296347-fanlvxqs	288	2	ER	ER	NNP
cord-296347-fanlvxqs	288	3	lumenal	lumenal	JJ
cord-296347-fanlvxqs	288	4	proteins	protein	NNS
cord-296347-fanlvxqs	288	5	require	require	VBP
cord-296347-fanlvxqs	288	6	the	the	DT
cord-296347-fanlvxqs	288	7	lumenal	lumenal	JJ
cord-296347-fanlvxqs	288	8	chaperone	chaperone	NN
cord-296347-fanlvxqs	288	9	BiP	BiP	NNP
cord-296347-fanlvxqs	288	10	for	for	IN
cord-296347-fanlvxqs	288	11	degradation	degradation	NN
cord-296347-fanlvxqs	288	12	,	,	,
cord-296347-fanlvxqs	288	13	while	while	IN
cord-296347-fanlvxqs	288	14	transmembrane	transmembrane	NN
cord-296347-fanlvxqs	288	15	proteins	protein	NNS
cord-296347-fanlvxqs	288	16	with	with	IN
cord-296347-fanlvxqs	288	17	large	large	JJ
cord-296347-fanlvxqs	288	18	cytosolic	cytosolic	JJ
cord-296347-fanlvxqs	288	19	domains	domain	NNS
cord-296347-fanlvxqs	288	20	usually	usually	RB
cord-296347-fanlvxqs	288	21	rely	rely	VBP
cord-296347-fanlvxqs	288	22	on	on	IN
cord-296347-fanlvxqs	288	23	cytosolic	cytosolic	JJ
cord-296347-fanlvxqs	288	24	chaperone	chaperone	NN
cord-296347-fanlvxqs	288	25	systems	system	NNS
cord-296347-fanlvxqs	288	26	,	,	,
cord-296347-fanlvxqs	288	27	like	like	IN
cord-296347-fanlvxqs	288	28	the	the	DT
cord-296347-fanlvxqs	288	29	heat	heat	NN
cord-296347-fanlvxqs	288	30	shock	shock	NN
cord-296347-fanlvxqs	288	31	protein	protein	NN
cord-296347-fanlvxqs	288	32	(	(	-LRB-
cord-296347-fanlvxqs	288	33	HSP	HSP	NNP
cord-296347-fanlvxqs	288	34	)	)	-RRB-
cord-296347-fanlvxqs	288	35	complexes	complex	NNS
cord-296347-fanlvxqs	289	1	Hsp70	Hsp70	NNP
cord-296347-fanlvxqs	289	2	/	/	SYM
cord-296347-fanlvxqs	289	3	Hsp90	Hsp90	NNP
cord-296347-fanlvxqs	289	4	and	and	CC
cord-296347-fanlvxqs	290	1	Hsp40	Hsp40	NNP
cord-296347-fanlvxqs	290	2	/	/	SYM
cord-296347-fanlvxqs	290	3	Hsp70	Hsp70	NNP
cord-296347-fanlvxqs	290	4	(	(	-LRB-
cord-296347-fanlvxqs	290	5	Ellgaard	Ellgaard	NNP
cord-296347-fanlvxqs	290	6	and	and	CC
cord-296347-fanlvxqs	290	7	Helenius	Helenius	NNP
cord-296347-fanlvxqs	290	8	,	,	,
cord-296347-fanlvxqs	290	9	2003	2003	CD
cord-296347-fanlvxqs	290	10	;	;	:
cord-296347-fanlvxqs	290	11	Romisch	Romisch	NNP
cord-296347-fanlvxqs	290	12	,	,	,
cord-296347-fanlvxqs	290	13	2005	2005	CD
cord-296347-fanlvxqs	290	14	)	)	-RRB-
cord-296347-fanlvxqs	290	15	.	.	.
cord-296347-fanlvxqs	291	1	Yet	yet	CC
cord-296347-fanlvxqs	291	2	it	-PRON-	PRP
cord-296347-fanlvxqs	291	3	appears	appear	VBZ
cord-296347-fanlvxqs	291	4	that	that	IN
cord-296347-fanlvxqs	291	5	a	a	DT
cord-296347-fanlvxqs	291	6	protein	protein	NN
cord-296347-fanlvxqs	291	7	's	's	POS
cord-296347-fanlvxqs	291	8	lumenal	lumenal	JJ
cord-296347-fanlvxqs	291	9	or	or	CC
cord-296347-fanlvxqs	291	10	ER	ER	NNP
cord-296347-fanlvxqs	291	11	membrane	membrane	NN
cord-296347-fanlvxqs	291	12	localization	localization	NN
cord-296347-fanlvxqs	291	13	matters	matter	VBZ
cord-296347-fanlvxqs	291	14	less	less	JJR
cord-296347-fanlvxqs	291	15	than	than	IN
cord-296347-fanlvxqs	291	16	the	the	DT
cord-296347-fanlvxqs	291	17	localization	localization	NN
cord-296347-fanlvxqs	291	18	of	of	IN
cord-296347-fanlvxqs	291	19	the	the	DT
cord-296347-fanlvxqs	291	20	folding	folding	NN
cord-296347-fanlvxqs	291	21	alteration	alteration	NN
cord-296347-fanlvxqs	291	22	within	within	IN
cord-296347-fanlvxqs	291	23	the	the	DT
cord-296347-fanlvxqs	291	24	polypeptide	polypeptide	NN
cord-296347-fanlvxqs	291	25	itself	-PRON-	PRP
cord-296347-fanlvxqs	291	26	.	.	.
cord-296347-fanlvxqs	292	1	CFTR	CFTR	NNP
cord-296347-fanlvxqs	292	2	whose	whose	WP$
cord-296347-fanlvxqs	292	3	cytoplasmic	cytoplasmic	JJ
cord-296347-fanlvxqs	292	4	domains	domain	NNS
cord-296347-fanlvxqs	292	5	are	be	VBP
cord-296347-fanlvxqs	292	6	recognized	recognize	VBN
cord-296347-fanlvxqs	292	7	first	first	RB
cord-296347-fanlvxqs	292	8	by	by	IN
cord-296347-fanlvxqs	292	9	the	the	DT
cord-296347-fanlvxqs	292	10	Hsp70	Hsp70	NNP
cord-296347-fanlvxqs	292	11	/	/	SYM
cord-296347-fanlvxqs	292	12	Hsp90	Hsp90	NNP
cord-296347-fanlvxqs	292	13	cytoplasmic	cytoplasmic	JJ
cord-296347-fanlvxqs	292	14	chaperone	chaperone	NN
cord-296347-fanlvxqs	292	15	system	system	NN
cord-296347-fanlvxqs	292	16	may	may	MD
cord-296347-fanlvxqs	292	17	be	be	VB
cord-296347-fanlvxqs	292	18	targeted	target	VBN
cord-296347-fanlvxqs	292	19	for	for	IN
cord-296347-fanlvxqs	292	20	degradation	degradation	NN
cord-296347-fanlvxqs	292	21	by	by	IN
cord-296347-fanlvxqs	292	22	the	the	DT
cord-296347-fanlvxqs	292	23	cytosolic	cytosolic	JJ
cord-296347-fanlvxqs	292	24	Hsp70	Hsp70	NNP
cord-296347-fanlvxqs	292	25	/	/	SYM
cord-296347-fanlvxqs	292	26	Hsp90-interacting	hsp90-interacting	NN
cord-296347-fanlvxqs	292	27	CHIP	chip	NN
cord-296347-fanlvxqs	292	28	E3	E3	NNP
cord-296347-fanlvxqs	292	29	ligase	ligase	NN
cord-296347-fanlvxqs	292	30	cochaperone	cochaperone	NNP
cord-296347-fanlvxqs	292	31	(	(	-LRB-
cord-296347-fanlvxqs	292	32	Connell	Connell	NNP
cord-296347-fanlvxqs	292	33	et	et	NNP
cord-296347-fanlvxqs	292	34	al	al	NNP
cord-296347-fanlvxqs	292	35	.	.	NNP
cord-296347-fanlvxqs	292	36	,	,	,
cord-296347-fanlvxqs	292	37	2001	2001	CD
cord-296347-fanlvxqs	292	38	;	;	:
cord-296347-fanlvxqs	293	1	Murata	Murata	NNP
cord-296347-fanlvxqs	293	2	et	et	NNP
cord-296347-fanlvxqs	293	3	al	al	NNP
cord-296347-fanlvxqs	293	4	.	.	NNP
cord-296347-fanlvxqs	293	5	,	,	,
cord-296347-fanlvxqs	293	6	2001	2001	CD
cord-296347-fanlvxqs	293	7	)	)	-RRB-
cord-296347-fanlvxqs	293	8	,	,	,
cord-296347-fanlvxqs	293	9	even	even	RB
cord-296347-fanlvxqs	293	10	if	if	IN
cord-296347-fanlvxqs	293	11	the	the	DT
cord-296347-fanlvxqs	293	12	protein	protein	NN
cord-296347-fanlvxqs	293	13	also	also	RB
cord-296347-fanlvxqs	293	14	has	have	VBZ
cord-296347-fanlvxqs	293	15	a	a	DT
cord-296347-fanlvxqs	293	16	misfolded	misfolde	VBN
cord-296347-fanlvxqs	293	17	lumenal	lumenal	JJ
cord-296347-fanlvxqs	293	18	domain	domain	NN
cord-296347-fanlvxqs	293	19	(	(	-LRB-
cord-296347-fanlvxqs	293	20	which	which	WDT
cord-296347-fanlvxqs	293	21	might	may	MD
cord-296347-fanlvxqs	293	22	also	also	RB
cord-296347-fanlvxqs	293	23	target	target	VB
cord-296347-fanlvxqs	293	24	it	-PRON-	PRP
cord-296347-fanlvxqs	293	25	to	to	IN
cord-296347-fanlvxqs	293	26	a	a	DT
cord-296347-fanlvxqs	293	27	BiP	bip	NN
cord-296347-fanlvxqs	293	28	-	-	HYPH
cord-296347-fanlvxqs	293	29	dependent	dependent	JJ
cord-296347-fanlvxqs	293	30	degradation	degradation	NN
cord-296347-fanlvxqs	293	31	pathway	pathway	NN
cord-296347-fanlvxqs	293	32	)	)	-RRB-
cord-296347-fanlvxqs	293	33	.	.	.
cord-296347-fanlvxqs	294	1	If	if	IN
cord-296347-fanlvxqs	294	2	the	the	DT
cord-296347-fanlvxqs	294	3	cytoplasmic	cytoplasmic	JJ
cord-296347-fanlvxqs	294	4	domain	domain	NN
cord-296347-fanlvxqs	294	5	is	be	VBZ
cord-296347-fanlvxqs	294	6	properly	properly	RB
cord-296347-fanlvxqs	294	7	folded	fold	VBN
cord-296347-fanlvxqs	294	8	,	,	,
cord-296347-fanlvxqs	294	9	then	then	RB
cord-296347-fanlvxqs	294	10	the	the	DT
cord-296347-fanlvxqs	294	11	lumenal	lumenal	JJ
cord-296347-fanlvxqs	294	12	domains	domain	NNS
cord-296347-fanlvxqs	294	13	are	be	VBP
cord-296347-fanlvxqs	294	14	inspected	inspect	VBN
cord-296347-fanlvxqs	294	15	,	,	,
cord-296347-fanlvxqs	294	16	and	and	CC
cord-296347-fanlvxqs	294	17	if	if	IN
cord-296347-fanlvxqs	294	18	then	then	RB
cord-296347-fanlvxqs	294	19	the	the	DT
cord-296347-fanlvxqs	294	20	protein	protein	NN
cord-296347-fanlvxqs	294	21	is	be	VBZ
cord-296347-fanlvxqs	294	22	recognized	recognize	VBN
cord-296347-fanlvxqs	294	23	as	as	IN
cord-296347-fanlvxqs	294	24	misfolded	misfolde	VBN
cord-296347-fanlvxqs	294	25	,	,	,
cord-296347-fanlvxqs	294	26	it	-PRON-	PRP
cord-296347-fanlvxqs	294	27	is	be	VBZ
cord-296347-fanlvxqs	294	28	degraded	degrade	VBN
cord-296347-fanlvxqs	294	29	in	in	IN
cord-296347-fanlvxqs	294	30	a	a	DT
cord-296347-fanlvxqs	294	31	process	process	NN
cord-296347-fanlvxqs	294	32	that	that	WDT
cord-296347-fanlvxqs	294	33	involves	involve	VBZ
cord-296347-fanlvxqs	294	34	BiP	BiP	NNP
cord-296347-fanlvxqs	294	35	(	(	-LRB-
cord-296347-fanlvxqs	294	36	Connell	Connell	NNP
cord-296347-fanlvxqs	294	37	et	et	NNP
cord-296347-fanlvxqs	294	38	al	al	NNP
cord-296347-fanlvxqs	294	39	.	.	NNP
cord-296347-fanlvxqs	294	40	,	,	,
cord-296347-fanlvxqs	294	41	2001	2001	CD
cord-296347-fanlvxqs	294	42	;	;	:
cord-296347-fanlvxqs	294	43	Meacham	Meacham	NNP
cord-296347-fanlvxqs	294	44	et	et	NNP
cord-296347-fanlvxqs	294	45	al	al	NNP
cord-296347-fanlvxqs	294	46	.	.	NNP
cord-296347-fanlvxqs	294	47	,	,	,
cord-296347-fanlvxqs	294	48	2001	2001	CD
cord-296347-fanlvxqs	294	49	;	;	:
cord-296347-fanlvxqs	294	50	Vashist	Vashist	NNP
cord-296347-fanlvxqs	294	51	and	and	CC
cord-296347-fanlvxqs	294	52	Ng	Ng	NNP
cord-296347-fanlvxqs	294	53	,	,	,
cord-296347-fanlvxqs	294	54	2004	2004	CD
cord-296347-fanlvxqs	294	55	)	)	-RRB-
cord-296347-fanlvxqs	294	56	.	.	.
cord-296347-fanlvxqs	295	1	This	this	DT
cord-296347-fanlvxqs	295	2	suggests	suggest	VBZ
cord-296347-fanlvxqs	295	3	that	that	IN
cord-296347-fanlvxqs	295	4	ER	ER	NNP
cord-296347-fanlvxqs	295	5	quality	quality	NN
cord-296347-fanlvxqs	295	6	control	control	NN
cord-296347-fanlvxqs	295	7	uses	use	VBZ
cord-296347-fanlvxqs	295	8	sequential	sequential	JJ
cord-296347-fanlvxqs	295	9	checkpoints	checkpoint	NNS
cord-296347-fanlvxqs	295	10	to	to	TO
cord-296347-fanlvxqs	295	11	select	select	VB
cord-296347-fanlvxqs	295	12	degradation	degradation	NN
cord-296347-fanlvxqs	295	13	substrates	substrate	NNS
cord-296347-fanlvxqs	295	14	and	and	CC
cord-296347-fanlvxqs	295	15	target	target	VB
cord-296347-fanlvxqs	295	16	them	-PRON-	PRP
cord-296347-fanlvxqs	295	17	to	to	IN
cord-296347-fanlvxqs	295	18	the	the	DT
cord-296347-fanlvxqs	295	19	appropriate	appropriate	JJ
cord-296347-fanlvxqs	295	20	degradation	degradation	NN
cord-296347-fanlvxqs	295	21	pathway	pathway	NN
cord-296347-fanlvxqs	295	22	.	.	.
cord-296347-fanlvxqs	296	1	In	in	IN
cord-296347-fanlvxqs	296	2	the	the	DT
cord-296347-fanlvxqs	296	3	case	case	NN
cord-296347-fanlvxqs	296	4	of	of	IN
cord-296347-fanlvxqs	296	5	nonglycosylated	nonglycosylated	JJ
cord-296347-fanlvxqs	296	6	substrates	substrate	NNS
cord-296347-fanlvxqs	296	7	,	,	,
cord-296347-fanlvxqs	296	8	protein	protein	NN
cord-296347-fanlvxqs	296	9	disulfide	disulfide	NN
cord-296347-fanlvxqs	296	10	isomerase	isomerase	NN
cord-296347-fanlvxqs	296	11	(	(	-LRB-
cord-296347-fanlvxqs	296	12	PDI	PDI	NNP
cord-296347-fanlvxqs	296	13	)	)	-RRB-
cord-296347-fanlvxqs	296	14	,	,	,
cord-296347-fanlvxqs	296	15	one	one	CD
cord-296347-fanlvxqs	296	16	of	of	IN
cord-296347-fanlvxqs	296	17	a	a	DT
cord-296347-fanlvxqs	296	18	large	large	JJ
cord-296347-fanlvxqs	296	19	number	number	NN
cord-296347-fanlvxqs	296	20	of	of	IN
cord-296347-fanlvxqs	296	21	ER	er	NN
cord-296347-fanlvxqs	296	22	-	-	HYPH
cord-296347-fanlvxqs	296	23	resident	resident	JJ
cord-296347-fanlvxqs	296	24	oxidoreductases	oxidoreductase	NNS
cord-296347-fanlvxqs	296	25	that	that	WDT
cord-296347-fanlvxqs	296	26	catalyze	catalyze	VBP
cord-296347-fanlvxqs	296	27	disulfide	disulfide	JJ
cord-296347-fanlvxqs	296	28	bond	bond	NN
cord-296347-fanlvxqs	296	29	formation	formation	NN
cord-296347-fanlvxqs	296	30	and	and	CC
cord-296347-fanlvxqs	296	31	isomerization	isomerization	NN
cord-296347-fanlvxqs	296	32	,	,	,
cord-296347-fanlvxqs	296	33	can	can	MD
cord-296347-fanlvxqs	296	34	play	play	VB
cord-296347-fanlvxqs	296	35	a	a	DT
cord-296347-fanlvxqs	296	36	role	role	NN
cord-296347-fanlvxqs	296	37	in	in	IN
cord-296347-fanlvxqs	296	38	ER	ER	NNP
cord-296347-fanlvxqs	296	39	quality	quality	NN
cord-296347-fanlvxqs	296	40	control	control	NN
cord-296347-fanlvxqs	296	41	by	by	IN
cord-296347-fanlvxqs	296	42	unfolding	unfold	VBG
cord-296347-fanlvxqs	296	43	certain	certain	JJ
cord-296347-fanlvxqs	296	44	substrates	substrate	NNS
cord-296347-fanlvxqs	296	45	prior	prior	RB
cord-296347-fanlvxqs	296	46	to	to	IN
cord-296347-fanlvxqs	296	47	degradation	degradation	NN
cord-296347-fanlvxqs	296	48	.	.	.
cord-296347-fanlvxqs	297	1	Another	another	DT
cord-296347-fanlvxqs	297	2	oxidoreductase	oxidoreductase	NN
cord-296347-fanlvxqs	297	3	,	,	,
cord-296347-fanlvxqs	297	4	ERp57	ERp57	NNS
cord-296347-fanlvxqs	297	5	,	,	,
cord-296347-fanlvxqs	297	6	interacts	interact	VBZ
cord-296347-fanlvxqs	297	7	with	with	IN
cord-296347-fanlvxqs	297	8	CNX	CNX	NNP
cord-296347-fanlvxqs	297	9	and	and	CC
cord-296347-fanlvxqs	297	10	CRT	CRT	NNP
cord-296347-fanlvxqs	297	11	to	to	TO
cord-296347-fanlvxqs	297	12	facilitate	facilitate	VB
cord-296347-fanlvxqs	297	13	folding	folding	NN
cord-296347-fanlvxqs	297	14	,	,	,
cord-296347-fanlvxqs	297	15	but	but	CC
cord-296347-fanlvxqs	297	16	in	in	IN
cord-296347-fanlvxqs	297	17	the	the	DT
cord-296347-fanlvxqs	297	18	event	event	NN
cord-296347-fanlvxqs	297	19	of	of	IN
cord-296347-fanlvxqs	297	20	a	a	DT
cord-296347-fanlvxqs	297	21	terminally	terminally	RB
cord-296347-fanlvxqs	297	22	misfolded	misfolde	VBN
cord-296347-fanlvxqs	297	23	protein	protein	NN
cord-296347-fanlvxqs	297	24	may	may	MD
cord-296347-fanlvxqs	297	25	aid	aid	VB
cord-296347-fanlvxqs	297	26	in	in	IN
cord-296347-fanlvxqs	297	27	transfer	transfer	NN
cord-296347-fanlvxqs	297	28	of	of	IN
cord-296347-fanlvxqs	297	29	proteins	protein	NNS
cord-296347-fanlvxqs	297	30	with	with	IN
cord-296347-fanlvxqs	297	31	improper	improper	JJ
cord-296347-fanlvxqs	297	32	disulfide	disulfide	NN
cord-296347-fanlvxqs	297	33	bonds	bond	NNS
cord-296347-fanlvxqs	297	34	to	to	IN
cord-296347-fanlvxqs	297	35	the	the	DT
cord-296347-fanlvxqs	297	36	EDEM	EDEM	NNP
cord-296347-fanlvxqs	297	37	pathway	pathway	NN
cord-296347-fanlvxqs	297	38	.	.	.
cord-296347-fanlvxqs	298	1	Another	another	DT
cord-296347-fanlvxqs	298	2	possibility	possibility	NN
cord-296347-fanlvxqs	298	3	,	,	,
cord-296347-fanlvxqs	298	4	at	at	IN
cord-296347-fanlvxqs	298	5	least	least	JJS
cord-296347-fanlvxqs	298	6	in	in	IN
cord-296347-fanlvxqs	298	7	yeast	yeast	NN
cord-296347-fanlvxqs	298	8	,	,	,
cord-296347-fanlvxqs	298	9	is	be	VBZ
cord-296347-fanlvxqs	298	10	that	that	IN
cord-296347-fanlvxqs	298	11	misfolded	misfolde	VBN
cord-296347-fanlvxqs	298	12	proteins	protein	NNS
cord-296347-fanlvxqs	298	13	actually	actually	RB
cord-296347-fanlvxqs	298	14	escape	escape	VBP
cord-296347-fanlvxqs	298	15	to	to	IN
cord-296347-fanlvxqs	298	16	the	the	DT
cord-296347-fanlvxqs	298	17	Golgi	Golgi	NNP
cord-296347-fanlvxqs	298	18	and	and	CC
cord-296347-fanlvxqs	298	19	are	be	VBP
cord-296347-fanlvxqs	298	20	then	then	RB
cord-296347-fanlvxqs	298	21	recycled	recycle	VBN
cord-296347-fanlvxqs	298	22	to	to	IN
cord-296347-fanlvxqs	298	23	the	the	DT
cord-296347-fanlvxqs	298	24	ER	ER	NNP
cord-296347-fanlvxqs	298	25	Vashist	Vashist	NNP
cord-296347-fanlvxqs	298	26	et	et	NNP
cord-296347-fanlvxqs	298	27	al	al	NNP
cord-296347-fanlvxqs	298	28	.	.	NNP
cord-296347-fanlvxqs	298	29	,	,	,
cord-296347-fanlvxqs	298	30	2001	2001	CD
cord-296347-fanlvxqs	298	31	)	)	-RRB-
cord-296347-fanlvxqs	298	32	.	.	.
cord-296347-fanlvxqs	299	1	This	this	DT
cord-296347-fanlvxqs	299	2	ER	ER	NNP
cord-296347-fanlvxqs	299	3	-	-	HYPH
cord-296347-fanlvxqs	299	4	Golgi	Golgi	NNP
cord-296347-fanlvxqs	299	5	shuttling	shuttling	NN
cord-296347-fanlvxqs	299	6	model	model	NN
cord-296347-fanlvxqs	299	7	was	be	VBD
cord-296347-fanlvxqs	299	8	proposed	propose	VBN
cord-296347-fanlvxqs	299	9	because	because	IN
cord-296347-fanlvxqs	299	10	mutations	mutation	NNS
cord-296347-fanlvxqs	299	11	in	in	IN
cord-296347-fanlvxqs	299	12	several	several	JJ
cord-296347-fanlvxqs	299	13	secretory	secretory	JJ
cord-296347-fanlvxqs	299	14	pathway	pathway	NN
cord-296347-fanlvxqs	299	15	genes	gene	NNS
cord-296347-fanlvxqs	299	16	(	(	-LRB-
cord-296347-fanlvxqs	299	17	like	like	IN
cord-296347-fanlvxqs	299	18	Ufe1p	Ufe1p	NNP
cord-296347-fanlvxqs	299	19	,	,	,
cord-296347-fanlvxqs	299	20	Sec23p	Sec23p	NNP
cord-296347-fanlvxqs	299	21	,	,	,
cord-296347-fanlvxqs	299	22	and	and	CC
cord-296347-fanlvxqs	299	23	Erv29p	Erv29p	NNP
cord-296347-fanlvxqs	299	24	)	)	-RRB-
cord-296347-fanlvxqs	299	25	compromise	compromise	NN
cord-296347-fanlvxqs	299	26	degradation	degradation	NN
cord-296347-fanlvxqs	299	27	of	of	IN
cord-296347-fanlvxqs	299	28	ERAD	ERAD	NNP
cord-296347-fanlvxqs	299	29	substrates	substrate	NNS
cord-296347-fanlvxqs	300	1	Vashist	Vashist	NNP
cord-296347-fanlvxqs	300	2	et	et	NNP
cord-296347-fanlvxqs	300	3	al	al	NNP
cord-296347-fanlvxqs	300	4	.	.	NNP
cord-296347-fanlvxqs	300	5	,	,	,
cord-296347-fanlvxqs	300	6	2001	2001	CD
cord-296347-fanlvxqs	300	7	)	)	-RRB-
cord-296347-fanlvxqs	300	8	,	,	,
cord-296347-fanlvxqs	300	9	invoking	invoke	VBG
cord-296347-fanlvxqs	300	10	a	a	DT
cord-296347-fanlvxqs	300	11	functional	functional	JJ
cord-296347-fanlvxqs	300	12	secretory	secretory	JJ
cord-296347-fanlvxqs	300	13	pathway	pathway	NN
cord-296347-fanlvxqs	300	14	for	for	IN
cord-296347-fanlvxqs	300	15	efficient	efficient	JJ
cord-296347-fanlvxqs	300	16	degradation	degradation	NN
cord-296347-fanlvxqs	300	17	of	of	IN
cord-296347-fanlvxqs	300	18	misfolded	misfolded	JJ
cord-296347-fanlvxqs	300	19	proteins	protein	NNS
cord-296347-fanlvxqs	300	20	from	from	IN
cord-296347-fanlvxqs	300	21	the	the	DT
cord-296347-fanlvxqs	300	22	ER	ER	NNP
cord-296347-fanlvxqs	300	23	.	.	.
cord-296347-fanlvxqs	301	1	The	the	DT
cord-296347-fanlvxqs	301	2	Golgi	Golgi	NNP
cord-296347-fanlvxqs	301	3	apparatus	apparatus	NN
cord-296347-fanlvxqs	301	4	could	could	MD
cord-296347-fanlvxqs	301	5	presumably	presumably	RB
cord-296347-fanlvxqs	301	6	endow	endow	VB
cord-296347-fanlvxqs	301	7	misfolded	misfolded	JJ
cord-296347-fanlvxqs	301	8	proteins	protein	NNS
cord-296347-fanlvxqs	301	9	with	with	IN
cord-296347-fanlvxqs	301	10	a	a	DT
cord-296347-fanlvxqs	301	11	signal	signal	NN
cord-296347-fanlvxqs	301	12	for	for	IN
cord-296347-fanlvxqs	301	13	destruction	destruction	NN
cord-296347-fanlvxqs	301	14	,	,	,
cord-296347-fanlvxqs	301	15	but	but	CC
cord-296347-fanlvxqs	301	16	such	such	PDT
cord-296347-fanlvxqs	301	17	a	a	DT
cord-296347-fanlvxqs	301	18	modification	modification	NN
cord-296347-fanlvxqs	301	19	has	have	VBZ
cord-296347-fanlvxqs	301	20	not	not	RB
cord-296347-fanlvxqs	301	21	been	be	VBN
cord-296347-fanlvxqs	301	22	found	find	VBN
cord-296347-fanlvxqs	301	23	.	.	.
cord-296347-fanlvxqs	302	1	Since	since	IN
cord-296347-fanlvxqs	302	2	the	the	DT
cord-296347-fanlvxqs	302	3	Ufe1p	Ufe1p	NNP
cord-296347-fanlvxqs	302	4	and	and	CC
cord-296347-fanlvxqs	302	5	Sec23p	Sec23p	NNP
cord-296347-fanlvxqs	302	6	have	have	VBP
cord-296347-fanlvxqs	302	7	since	since	IN
cord-296347-fanlvxqs	302	8	been	be	VBN
cord-296347-fanlvxqs	302	9	shown	show	VBN
cord-296347-fanlvxqs	302	10	to	to	TO
cord-296347-fanlvxqs	302	11	be	be	VB
cord-296347-fanlvxqs	302	12	required	require	VBN
cord-296347-fanlvxqs	302	13	for	for	IN
cord-296347-fanlvxqs	302	14	maintenance	maintenance	NN
cord-296347-fanlvxqs	302	15	of	of	IN
cord-296347-fanlvxqs	302	16	proper	proper	JJ
cord-296347-fanlvxqs	302	17	ER	er	NN
cord-296347-fanlvxqs	302	18	structure	structure	NN
cord-296347-fanlvxqs	303	1	(	(	-LRB-
cord-296347-fanlvxqs	303	2	Prinz	Prinz	NNP
cord-296347-fanlvxqs	303	3	et	et	NNP
cord-296347-fanlvxqs	303	4	al	al	NNP
cord-296347-fanlvxqs	303	5	.	.	NNP
cord-296347-fanlvxqs	303	6	,	,	,
cord-296347-fanlvxqs	303	7	2000	2000	CD
cord-296347-fanlvxqs	303	8	)	)	-RRB-
cord-296347-fanlvxqs	303	9	,	,	,
cord-296347-fanlvxqs	303	10	the	the	DT
cord-296347-fanlvxqs	303	11	effects	effect	NNS
cord-296347-fanlvxqs	303	12	on	on	IN
cord-296347-fanlvxqs	303	13	protein	protein	NN
cord-296347-fanlvxqs	303	14	degradation	degradation	NN
cord-296347-fanlvxqs	303	15	may	may	MD
cord-296347-fanlvxqs	303	16	simply	simply	RB
cord-296347-fanlvxqs	303	17	be	be	VB
cord-296347-fanlvxqs	303	18	pleiotropic	pleiotropic	JJ
cord-296347-fanlvxqs	303	19	consequences	consequence	NNS
cord-296347-fanlvxqs	303	20	of	of	IN
cord-296347-fanlvxqs	303	21	perturbing	perturb	VBG
cord-296347-fanlvxqs	303	22	the	the	DT
cord-296347-fanlvxqs	303	23	normal	normal	JJ
cord-296347-fanlvxqs	303	24	arquitecture	arquitecture	NN
cord-296347-fanlvxqs	303	25	of	of	IN
cord-296347-fanlvxqs	303	26	the	the	DT
cord-296347-fanlvxqs	303	27	ER	ER	NNP
cord-296347-fanlvxqs	304	1	(	(	-LRB-
cord-296347-fanlvxqs	304	2	Hammond	Hammond	NNP
cord-296347-fanlvxqs	304	3	et	et	NNP
cord-296347-fanlvxqs	304	4	al	al	NNP
cord-296347-fanlvxqs	304	5	.	.	.
cord-296347-fanlvxqs	305	1	,	,	,
cord-296347-fanlvxqs	305	2	1994	1994	CD
cord-296347-fanlvxqs	305	3	;	;	:
cord-296347-fanlvxqs	305	4	Romisch	Romisch	NNP
cord-296347-fanlvxqs	305	5	,	,	,
cord-296347-fanlvxqs	305	6	2005	2005	CD
cord-296347-fanlvxqs	305	7	)	)	-RRB-
cord-296347-fanlvxqs	305	8	.	.	.
cord-296347-fanlvxqs	306	1	Ubiquitination	Ubiquitination	NNP
cord-296347-fanlvxqs	306	2	at	at	IN
cord-296347-fanlvxqs	306	3	the	the	DT
cord-296347-fanlvxqs	306	4	ER	ER	NNP
cord-296347-fanlvxqs	306	5	membrane	membrane	NN
cord-296347-fanlvxqs	306	6	is	be	VBZ
cord-296347-fanlvxqs	306	7	yet	yet	RB
cord-296347-fanlvxqs	306	8	another	another	DT
cord-296347-fanlvxqs	306	9	mode	mode	NN
cord-296347-fanlvxqs	306	10	of	of	IN
cord-296347-fanlvxqs	306	11	ERAD	ERAD	NNP
cord-296347-fanlvxqs	306	12	substrate	substrate	NN
cord-296347-fanlvxqs	306	13	selection	selection	NN
cord-296347-fanlvxqs	306	14	.	.	.
cord-296347-fanlvxqs	307	1	Most	Most	JJS
cord-296347-fanlvxqs	307	2	ERAD	ERAD	NNP
cord-296347-fanlvxqs	307	3	E3s	e3s	NN
cord-296347-fanlvxqs	307	4	are	be	VBP
cord-296347-fanlvxqs	307	5	at	at	IN
cord-296347-fanlvxqs	307	6	the	the	DT
cord-296347-fanlvxqs	307	7	ER	ER	NNP
cord-296347-fanlvxqs	307	8	membrane	membrane	NN
cord-296347-fanlvxqs	307	9	,	,	,
cord-296347-fanlvxqs	307	10	as	as	IN
cord-296347-fanlvxqs	307	11	is	be	VBZ
cord-296347-fanlvxqs	307	12	the	the	DT
cord-296347-fanlvxqs	307	13	case	case	NN
cord-296347-fanlvxqs	307	14	for	for	IN
cord-296347-fanlvxqs	307	15	the	the	DT
cord-296347-fanlvxqs	307	16	yeast	yeast	NN
cord-296347-fanlvxqs	307	17	Hrd1p/	Hrd1p/	NNP
cord-296347-fanlvxqs	307	18	Der3p	Der3p	NNP
cord-296347-fanlvxqs	307	19	and	and	CC
cord-296347-fanlvxqs	307	20	Doa10p	doa10p	CD
cord-296347-fanlvxqs	307	21	,	,	,
cord-296347-fanlvxqs	307	22	or	or	CC
cord-296347-fanlvxqs	307	23	can	can	MD
cord-296347-fanlvxqs	307	24	be	be	VB
cord-296347-fanlvxqs	307	25	brought	bring	VBN
cord-296347-fanlvxqs	307	26	to	to	IN
cord-296347-fanlvxqs	307	27	the	the	DT
cord-296347-fanlvxqs	307	28	ER	ER	NNP
cord-296347-fanlvxqs	307	29	membrane	membrane	NN
cord-296347-fanlvxqs	307	30	on	on	IN
cord-296347-fanlvxqs	307	31	demand	demand	NN
cord-296347-fanlvxqs	307	32	,	,	,
cord-296347-fanlvxqs	307	33	as	as	IN
cord-296347-fanlvxqs	307	34	is	be	VBZ
cord-296347-fanlvxqs	307	35	the	the	DT
cord-296347-fanlvxqs	307	36	case	case	NN
cord-296347-fanlvxqs	307	37	for	for	IN
cord-296347-fanlvxqs	307	38	cytosolic	cytosolic	JJ
cord-296347-fanlvxqs	307	39	SCF	SCF	NNP
cord-296347-fanlvxqs	307	40	complexes	complex	NNS
cord-296347-fanlvxqs	307	41	and	and	CC
cord-296347-fanlvxqs	307	42	CHIP	chip	NN
cord-296347-fanlvxqs	307	43	,	,	,
cord-296347-fanlvxqs	307	44	for	for	IN
cord-296347-fanlvxqs	307	45	example	example	NN
cord-296347-fanlvxqs	308	1	(	(	-LRB-
cord-296347-fanlvxqs	308	2	Kostova	Kostova	NNP
cord-296347-fanlvxqs	308	3	and	and	CC
cord-296347-fanlvxqs	308	4	Wolf	Wolf	NNP
cord-296347-fanlvxqs	308	5	,	,	,
cord-296347-fanlvxqs	308	6	2003	2003	CD
cord-296347-fanlvxqs	308	7	;	;	:
cord-296347-fanlvxqs	308	8	Meusser	Meusser	NNP
cord-296347-fanlvxqs	308	9	et	et	NNP
cord-296347-fanlvxqs	308	10	al	al	NNP
cord-296347-fanlvxqs	308	11	.	.	NNP
cord-296347-fanlvxqs	308	12	,	,	,
cord-296347-fanlvxqs	308	13	2005	2005	CD
cord-296347-fanlvxqs	308	14	;	;	:
cord-296347-fanlvxqs	308	15	Romisch	Romisch	NNP
cord-296347-fanlvxqs	308	16	,	,	,
cord-296347-fanlvxqs	308	17	2005	2005	CD
cord-296347-fanlvxqs	308	18	)	)	-RRB-
cord-296347-fanlvxqs	308	19	.	.	.
cord-296347-fanlvxqs	309	1	An	an	DT
cord-296347-fanlvxqs	309	2	E3	e3	NN
cord-296347-fanlvxqs	309	3	ligase	ligase	NN
cord-296347-fanlvxqs	309	4	can	can	MD
cord-296347-fanlvxqs	309	5	recruit	recruit	VB
cord-296347-fanlvxqs	309	6	distinct	distinct	JJ
cord-296347-fanlvxqs	309	7	E2	E2	NNP
cord-296347-fanlvxqs	309	8	Ub	Ub	NNP
cord-296347-fanlvxqs	309	9	-	-	HYPH
cord-296347-fanlvxqs	309	10	conjugating	conjugate	VBG
cord-296347-fanlvxqs	309	11	enzymes	enzyme	NNS
cord-296347-fanlvxqs	309	12	and/or	and/or	CC
cord-296347-fanlvxqs	309	13	distinct	distinct	JJ
cord-296347-fanlvxqs	309	14	adaptor	adaptor	NN
cord-296347-fanlvxqs	309	15	proteins	protein	NNS
cord-296347-fanlvxqs	309	16	(	(	-LRB-
cord-296347-fanlvxqs	309	17	as	as	IN
cord-296347-fanlvxqs	309	18	we	-PRON-	PRP
cord-296347-fanlvxqs	309	19	have	have	VBP
cord-296347-fanlvxqs	309	20	seen	see	VBN
cord-296347-fanlvxqs	309	21	for	for	IN
cord-296347-fanlvxqs	309	22	the	the	DT
cord-296347-fanlvxqs	309	23	SCF	SCF	NNP
cord-296347-fanlvxqs	309	24	and	and	CC
cord-296347-fanlvxqs	309	25	ECS	ECS	NNP
cord-296347-fanlvxqs	309	26	E3	E3	NNP
cord-296347-fanlvxqs	309	27	complexes	complex	NNS
cord-296347-fanlvxqs	309	28	and	and	CC
cord-296347-fanlvxqs	309	29	will	will	MD
cord-296347-fanlvxqs	309	30	discuss	discuss	VB
cord-296347-fanlvxqs	309	31	later	later	RB
cord-296347-fanlvxqs	309	32	for	for	IN
cord-296347-fanlvxqs	309	33	ERAD	ERAD	NNP
cord-296347-fanlvxqs	309	34	E3s	E3s	NNP
cord-296347-fanlvxqs	309	35	)	)	-RRB-
cord-296347-fanlvxqs	309	36	,	,	,
cord-296347-fanlvxqs	309	37	thus	thus	RB
cord-296347-fanlvxqs	309	38	conferring	confer	VBG
cord-296347-fanlvxqs	309	39	specificity	specificity	NN
cord-296347-fanlvxqs	309	40	in	in	IN
cord-296347-fanlvxqs	309	41	substrate	substrate	NN
cord-296347-fanlvxqs	309	42	selection	selection	NN
cord-296347-fanlvxqs	309	43	.	.	.
cord-296347-fanlvxqs	310	1	The	the	DT
cord-296347-fanlvxqs	310	2	yeast	yeast	NN
cord-296347-fanlvxqs	311	1	Hrd1p	Hrd1p	NNP
cord-296347-fanlvxqs	311	2	/	/	SYM
cord-296347-fanlvxqs	311	3	Der3p	Der3p	NNP
cord-296347-fanlvxqs	311	4	E3	E3	NNP
cord-296347-fanlvxqs	311	5	ligase	ligase	NN
cord-296347-fanlvxqs	311	6	was	be	VBD
cord-296347-fanlvxqs	311	7	first	first	RB
cord-296347-fanlvxqs	311	8	discovered	discover	VBN
cord-296347-fanlvxqs	311	9	in	in	IN
cord-296347-fanlvxqs	311	10	a	a	DT
cord-296347-fanlvxqs	311	11	genetic	genetic	JJ
cord-296347-fanlvxqs	311	12	screen	screen	NN
cord-296347-fanlvxqs	311	13	for	for	IN
cord-296347-fanlvxqs	311	14	Saccharomyces	Saccharomyces	NNP
cord-296347-fanlvxqs	311	15	cerevisiae	cerevisiae	NN
cord-296347-fanlvxqs	311	16	genes	gene	NNS
cord-296347-fanlvxqs	311	17	involved	involve	VBN
cord-296347-fanlvxqs	311	18	in	in	IN
cord-296347-fanlvxqs	311	19	HMG	HMG	NNP
cord-296347-fanlvxqs	311	20	-	-	HYPH
cord-296347-fanlvxqs	311	21	CoA	coa	NN
cord-296347-fanlvxqs	311	22	reductase	reductase	NN
cord-296347-fanlvxqs	311	23	degradation	degradation	NN
cord-296347-fanlvxqs	311	24	(	(	-LRB-
cord-296347-fanlvxqs	311	25	Hrp	Hrp	NNP
cord-296347-fanlvxqs	311	26	)	)	-RRB-
cord-296347-fanlvxqs	312	1	(	(	-LRB-
cord-296347-fanlvxqs	312	2	Hampton	Hampton	NNP
cord-296347-fanlvxqs	312	3	et	et	NNP
cord-296347-fanlvxqs	312	4	al	al	NNP
cord-296347-fanlvxqs	312	5	.	.	NNP
cord-296347-fanlvxqs	312	6	,	,	,
cord-296347-fanlvxqs	312	7	1996	1996	CD
cord-296347-fanlvxqs	312	8	)	)	-RRB-
cord-296347-fanlvxqs	313	1	and	and	CC
cord-296347-fanlvxqs	313	2	is	be	VBZ
cord-296347-fanlvxqs	313	3	an	an	DT
cord-296347-fanlvxqs	313	4	ER	ER	NNP
cord-296347-fanlvxqs	313	5	-	-	HYPH
cord-296347-fanlvxqs	313	6	resident	resident	JJ
cord-296347-fanlvxqs	313	7	protein	protein	NN
cord-296347-fanlvxqs	313	8	with	with	IN
cord-296347-fanlvxqs	313	9	six	six	CD
cord-296347-fanlvxqs	313	10	predicted	predict	VBN
cord-296347-fanlvxqs	313	11	transmembrane	transmembrane	NN
cord-296347-fanlvxqs	313	12	domains	domain	NNS
cord-296347-fanlvxqs	313	13	and	and	CC
cord-296347-fanlvxqs	313	14	a	a	DT
cord-296347-fanlvxqs	313	15	C	c	NN
cord-296347-fanlvxqs	313	16	-	-	HYPH
cord-296347-fanlvxqs	313	17	terminal	terminal	NN
cord-296347-fanlvxqs	313	18	RING	ring	NN
cord-296347-fanlvxqs	313	19	-	-	HYPH
cord-296347-fanlvxqs	313	20	finger	finger	NN
cord-296347-fanlvxqs	313	21	motif	motif	NN
cord-296347-fanlvxqs	313	22	facing	face	VBG
cord-296347-fanlvxqs	313	23	the	the	DT
cord-296347-fanlvxqs	313	24	cytosol	cytosol	NN
cord-296347-fanlvxqs	313	25	.	.	.
cord-296347-fanlvxqs	314	1	Hrd1p	Hrd1p	NNP
cord-296347-fanlvxqs	314	2	can	can	MD
cord-296347-fanlvxqs	314	3	act	act	VB
cord-296347-fanlvxqs	314	4	in	in	IN
cord-296347-fanlvxqs	314	5	a	a	DT
cord-296347-fanlvxqs	314	6	complex	complex	NN
cord-296347-fanlvxqs	314	7	with	with	IN
cord-296347-fanlvxqs	314	8	Ubc7p	Ubc7p	NNP
cord-296347-fanlvxqs	314	9	and	and	CC
cord-296347-fanlvxqs	314	10	Ubc6p	ubc6p	DT
cord-296347-fanlvxqs	314	11	to	to	TO
cord-296347-fanlvxqs	314	12	ubiquitinate	ubiquitinate	JJ
cord-296347-fanlvxqs	314	13	substrate	substrate	NN
cord-296347-fanlvxqs	314	14	proteins	protein	NNS
cord-296347-fanlvxqs	315	1	(	(	-LRB-
cord-296347-fanlvxqs	315	2	Fig	Fig	NNP
cord-296347-fanlvxqs	315	3	.	.	.
cord-296347-fanlvxqs	315	4	2B	2b	CD
cord-296347-fanlvxqs	315	5	)	)	-RRB-
cord-296347-fanlvxqs	315	6	.	.	.
cord-296347-fanlvxqs	316	1	Ubc7p	Ubc7p	NNP
cord-296347-fanlvxqs	316	2	is	be	VBZ
cord-296347-fanlvxqs	316	3	a	a	DT
cord-296347-fanlvxqs	316	4	soluble	soluble	JJ
cord-296347-fanlvxqs	316	5	protein	protein	NN
cord-296347-fanlvxqs	316	6	that	that	WDT
cord-296347-fanlvxqs	316	7	becomes	become	VBZ
cord-296347-fanlvxqs	316	8	active	active	JJ
cord-296347-fanlvxqs	316	9	only	only	RB
cord-296347-fanlvxqs	316	10	when	when	WRB
cord-296347-fanlvxqs	316	11	tethered	tether	VBN
cord-296347-fanlvxqs	316	12	to	to	IN
cord-296347-fanlvxqs	316	13	the	the	DT
cord-296347-fanlvxqs	316	14	ER	ER	NNP
cord-296347-fanlvxqs	316	15	membrane	membrane	NN
cord-296347-fanlvxqs	316	16	by	by	IN
cord-296347-fanlvxqs	316	17	the	the	DT
cord-296347-fanlvxqs	316	18	Ubc7p	Ubc7p	NNP
cord-296347-fanlvxqs	316	19	cofactor	cofactor	NN
cord-296347-fanlvxqs	316	20	Cue1p	Cue1p	NNP
cord-296347-fanlvxqs	316	21	membrane	membrane	NN
cord-296347-fanlvxqs	316	22	protein	protein	NN
cord-296347-fanlvxqs	316	23	.	.	.
cord-296347-fanlvxqs	317	1	Degradation	degradation	NN
cord-296347-fanlvxqs	317	2	of	of	IN
cord-296347-fanlvxqs	317	3	transcription	transcription	NN
cord-296347-fanlvxqs	317	4	factor	factor	NN
cord-296347-fanlvxqs	317	5	Mata2	Mata2	NNS
cord-296347-fanlvxqs	317	6	-	-	:
cord-296347-fanlvxqs	317	7	10	10	CD
cord-296347-fanlvxqs	317	8	protein	protein	NN
cord-296347-fanlvxqs	317	9	(	(	-LRB-
cord-296347-fanlvxqs	317	10	Doa10p	Doa10p	NNP
cord-296347-fanlvxqs	317	11	)	)	-RRB-
cord-296347-fanlvxqs	317	12	is	be	VBZ
cord-296347-fanlvxqs	317	13	a	a	DT
cord-296347-fanlvxqs	317	14	transmembrane	transmembrane	NN
cord-296347-fanlvxqs	317	15	protein	protein	NN
cord-296347-fanlvxqs	317	16	of	of	IN
cord-296347-fanlvxqs	317	17	the	the	DT
cord-296347-fanlvxqs	317	18	ER	ER	NNP
cord-296347-fanlvxqs	317	19	/	/	SYM
cord-296347-fanlvxqs	317	20	nuclear	nuclear	JJ
cord-296347-fanlvxqs	317	21	envelope	envelope	NN
cord-296347-fanlvxqs	317	22	,	,	,
cord-296347-fanlvxqs	317	23	which	which	WDT
cord-296347-fanlvxqs	317	24	participates	participate	VBZ
cord-296347-fanlvxqs	317	25	in	in	IN
cord-296347-fanlvxqs	317	26	yeast	yeast	NN
cord-296347-fanlvxqs	317	27	ERAD	ERAD	NNP
cord-296347-fanlvxqs	317	28	(	(	-LRB-
cord-296347-fanlvxqs	317	29	Swanson	Swanson	NNP
cord-296347-fanlvxqs	317	30	et	et	NNP
cord-296347-fanlvxqs	317	31	al	al	NNP
cord-296347-fanlvxqs	317	32	.	.	NNP
cord-296347-fanlvxqs	317	33	,	,	,
cord-296347-fanlvxqs	317	34	2001	2001	CD
cord-296347-fanlvxqs	317	35	)	)	-RRB-
cord-296347-fanlvxqs	317	36	.	.	.
cord-296347-fanlvxqs	318	1	Doa10p	Doa10p	NNP
cord-296347-fanlvxqs	318	2	is	be	VBZ
cord-296347-fanlvxqs	318	3	predicted	predict	VBN
cord-296347-fanlvxqs	318	4	to	to	TO
cord-296347-fanlvxqs	318	5	span	span	VB
cord-296347-fanlvxqs	318	6	the	the	DT
cord-296347-fanlvxqs	318	7	membrane	membrane	NN
cord-296347-fanlvxqs	318	8	14	14	CD
cord-296347-fanlvxqs	318	9	times	time	NNS
cord-296347-fanlvxqs	318	10	and	and	CC
cord-296347-fanlvxqs	318	11	,	,	,
cord-296347-fanlvxqs	318	12	like	like	IN
cord-296347-fanlvxqs	318	13	Hrd1p	Hrd1p	NNP
cord-296347-fanlvxqs	318	14	,	,	,
cord-296347-fanlvxqs	318	15	uses	use	VBZ
cord-296347-fanlvxqs	318	16	Cue1p	Cue1p	NNP
cord-296347-fanlvxqs	318	17	/	/	SYM
cord-296347-fanlvxqs	318	18	Ubc7p	Ubc7p	NNP
cord-296347-fanlvxqs	318	19	and	and	CC
cord-296347-fanlvxqs	318	20	Ubc6p	ubc6p	DT
cord-296347-fanlvxqs	318	21	to	to	TO
cord-296347-fanlvxqs	318	22	ubiquitinate	ubiquitinate	VB
cord-296347-fanlvxqs	318	23	its	-PRON-	PRP$
cord-296347-fanlvxqs	318	24	substrates	substrate	NNS
cord-296347-fanlvxqs	318	25	(	(	-LRB-
cord-296347-fanlvxqs	318	26	Fig	Fig	NNP
cord-296347-fanlvxqs	318	27	.	.	.
cord-296347-fanlvxqs	318	28	2B	2b	CD
cord-296347-fanlvxqs	318	29	)	)	-RRB-
cord-296347-fanlvxqs	318	30	.	.	.
cord-296347-fanlvxqs	319	1	However	however	RB
cord-296347-fanlvxqs	319	2	,	,	,
cord-296347-fanlvxqs	319	3	the	the	DT
cord-296347-fanlvxqs	319	4	two	two	CD
cord-296347-fanlvxqs	319	5	ligases	ligase	NNS
cord-296347-fanlvxqs	319	6	target	target	VBP
cord-296347-fanlvxqs	319	7	different	different	JJ
cord-296347-fanlvxqs	319	8	sets	set	NNS
cord-296347-fanlvxqs	319	9	of	of	IN
cord-296347-fanlvxqs	319	10	substrates	substrate	NNS
cord-296347-fanlvxqs	319	11	for	for	IN
cord-296347-fanlvxqs	319	12	degradation	degradation	NN
cord-296347-fanlvxqs	319	13	(	(	-LRB-
cord-296347-fanlvxqs	319	14	Bays	Bays	NNPS
cord-296347-fanlvxqs	319	15	et	et	NNP
cord-296347-fanlvxqs	319	16	al	al	NNP
cord-296347-fanlvxqs	319	17	.	.	NNP
cord-296347-fanlvxqs	319	18	,	,	,
cord-296347-fanlvxqs	319	19	2001	2001	CD
cord-296347-fanlvxqs	319	20	;	;	:
cord-296347-fanlvxqs	320	1	Swanson	Swanson	NNP
cord-296347-fanlvxqs	320	2	et	et	NNP
cord-296347-fanlvxqs	320	3	al	al	NNP
cord-296347-fanlvxqs	320	4	.	.	NNP
cord-296347-fanlvxqs	320	5	,	,	,
cord-296347-fanlvxqs	320	6	2001	2001	CD
cord-296347-fanlvxqs	320	7	)	)	-RRB-
cord-296347-fanlvxqs	320	8	.	.	.
cord-296347-fanlvxqs	321	1	Hrd1p	hrd1p	IN
cord-296347-fanlvxqs	321	2	ubiquitination	ubiquitination	NN
cord-296347-fanlvxqs	321	3	activity	activity	NN
cord-296347-fanlvxqs	321	4	can	can	MD
cord-296347-fanlvxqs	321	5	be	be	VB
cord-296347-fanlvxqs	321	6	directed	direct	VBN
cord-296347-fanlvxqs	321	7	to	to	IN
cord-296347-fanlvxqs	321	8	a	a	DT
cord-296347-fanlvxqs	321	9	specific	specific	JJ
cord-296347-fanlvxqs	321	10	subset	subset	NN
cord-296347-fanlvxqs	321	11	of	of	IN
cord-296347-fanlvxqs	321	12	ER	ER	NNP
cord-296347-fanlvxqs	321	13	degradation	degradation	NN
cord-296347-fanlvxqs	321	14	substrates	substrate	NNS
cord-296347-fanlvxqs	321	15	,	,	,
cord-296347-fanlvxqs	321	16	by	by	IN
cord-296347-fanlvxqs	321	17	virtue	virtue	NN
cord-296347-fanlvxqs	321	18	of	of	IN
cord-296347-fanlvxqs	321	19	its	-PRON-	PRP$
cord-296347-fanlvxqs	321	20	association	association	NN
cord-296347-fanlvxqs	321	21	of	of	IN
cord-296347-fanlvxqs	321	22	Hrd1p	Hrd1p	NNP
cord-296347-fanlvxqs	321	23	with	with	IN
cord-296347-fanlvxqs	321	24	Hrd3p	Hrd3p	NNP
cord-296347-fanlvxqs	321	25	and	and	CC
cord-296347-fanlvxqs	321	26	Der1p	Der1p	NNS
cord-296347-fanlvxqs	321	27	.	.	.
cord-296347-fanlvxqs	322	1	Hrd3p	Hrd3p	NNP
cord-296347-fanlvxqs	322	2	is	be	VBZ
cord-296347-fanlvxqs	322	3	a	a	DT
cord-296347-fanlvxqs	322	4	single	single	JJ
cord-296347-fanlvxqs	322	5	-	-	HYPH
cord-296347-fanlvxqs	322	6	spanning	span	VBG
cord-296347-fanlvxqs	322	7	ER	er	NN
cord-296347-fanlvxqs	322	8	membrane	membrane	NN
cord-296347-fanlvxqs	322	9	protein	protein	NN
cord-296347-fanlvxqs	322	10	with	with	IN
cord-296347-fanlvxqs	322	11	a	a	DT
cord-296347-fanlvxqs	322	12	large	large	JJ
cord-296347-fanlvxqs	322	13	ER	ER	NNP
cord-296347-fanlvxqs	322	14	luminal	luminal	JJ
cord-296347-fanlvxqs	322	15	domain	domain	NN
cord-296347-fanlvxqs	322	16	that	that	WDT
cord-296347-fanlvxqs	322	17	can	can	MD
cord-296347-fanlvxqs	322	18	recognize	recognize	VB
cord-296347-fanlvxqs	322	19	misfolded	misfolded	JJ
cord-296347-fanlvxqs	322	20	proteins	protein	NNS
cord-296347-fanlvxqs	322	21	,	,	,
cord-296347-fanlvxqs	322	22	thus	thus	RB
cord-296347-fanlvxqs	322	23	possibly	possibly	RB
cord-296347-fanlvxqs	322	24	functioning	function	VBG
cord-296347-fanlvxqs	322	25	as	as	IN
cord-296347-fanlvxqs	322	26	a	a	DT
cord-296347-fanlvxqs	322	27	substrate	substrate	NN
cord-296347-fanlvxqs	322	28	recruitment	recruitment	NN
cord-296347-fanlvxqs	322	29	factor	factor	NN
cord-296347-fanlvxqs	322	30	for	for	IN
cord-296347-fanlvxqs	322	31	the	the	DT
cord-296347-fanlvxqs	322	32	Hrd1p	hrd1p	NN
cord-296347-fanlvxqs	322	33	ligase	ligase	NN
cord-296347-fanlvxqs	322	34	complex	complex	NN
cord-296347-fanlvxqs	322	35	(	(	-LRB-
cord-296347-fanlvxqs	322	36	Gauss	Gauss	NNP
cord-296347-fanlvxqs	322	37	et	et	NNP
cord-296347-fanlvxqs	322	38	al	al	NNP
cord-296347-fanlvxqs	322	39	.	.	NNP
cord-296347-fanlvxqs	322	40	,	,	,
cord-296347-fanlvxqs	322	41	2006	2006	CD
cord-296347-fanlvxqs	322	42	)	)	-RRB-
cord-296347-fanlvxqs	322	43	.	.	.
cord-296347-fanlvxqs	323	1	The	the	DT
cord-296347-fanlvxqs	323	2	degradation	degradation	NN
cord-296347-fanlvxqs	323	3	from	from	IN
cord-296347-fanlvxqs	323	4	the	the	DT
cord-296347-fanlvxqs	323	5	ER-1	ER-1	NNP
cord-296347-fanlvxqs	323	6	protein	protein	NN
cord-296347-fanlvxqs	323	7	(	(	-LRB-
cord-296347-fanlvxqs	323	8	Der1p	Der1p	NNP
cord-296347-fanlvxqs	323	9	)	)	-RRB-
cord-296347-fanlvxqs	323	10	spans	span	VBZ
cord-296347-fanlvxqs	323	11	the	the	DT
cord-296347-fanlvxqs	323	12	ER	ER	NNP
cord-296347-fanlvxqs	323	13	membrane	membrane	NN
cord-296347-fanlvxqs	323	14	four	four	CD
cord-296347-fanlvxqs	323	15	times	time	NNS
cord-296347-fanlvxqs	323	16	and	and	CC
cord-296347-fanlvxqs	323	17	is	be	VBZ
cord-296347-fanlvxqs	323	18	required	require	VBN
cord-296347-fanlvxqs	323	19	for	for	IN
cord-296347-fanlvxqs	323	20	degradation	degradation	NN
cord-296347-fanlvxqs	323	21	of	of	IN
cord-296347-fanlvxqs	323	22	some	some	DT
cord-296347-fanlvxqs	323	23	misfolded	misfolde	VBN
cord-296347-fanlvxqs	323	24	glycoproteins	glycoprotein	NNS
cord-296347-fanlvxqs	323	25	(	(	-LRB-
cord-296347-fanlvxqs	323	26	Knop	Knop	NNP
cord-296347-fanlvxqs	323	27	et	et	FW
cord-296347-fanlvxqs	323	28	al	al	NNP
cord-296347-fanlvxqs	323	29	.	.	NNP
cord-296347-fanlvxqs	323	30	,	,	,
cord-296347-fanlvxqs	323	31	1996	1996	CD
cord-296347-fanlvxqs	323	32	)	)	-RRB-
cord-296347-fanlvxqs	323	33	.	.	.
cord-296347-fanlvxqs	324	1	Der1p	Der1p	NNP
cord-296347-fanlvxqs	324	2	may	may	MD
cord-296347-fanlvxqs	324	3	function	function	VB
cord-296347-fanlvxqs	324	4	as	as	IN
cord-296347-fanlvxqs	324	5	a	a	DT
cord-296347-fanlvxqs	324	6	substrate	substrate	NN
cord-296347-fanlvxqs	324	7	adaptor	adaptor	NN
cord-296347-fanlvxqs	324	8	protein	protein	NN
cord-296347-fanlvxqs	324	9	or	or	CC
cord-296347-fanlvxqs	324	10	even	even	RB
cord-296347-fanlvxqs	324	11	as	as	IN
cord-296347-fanlvxqs	324	12	a	a	DT
cord-296347-fanlvxqs	324	13	channel	channel	NN
cord-296347-fanlvxqs	324	14	for	for	IN
cord-296347-fanlvxqs	324	15	ejection	ejection	NN
cord-296347-fanlvxqs	324	16	of	of	IN
cord-296347-fanlvxqs	324	17	degradation	degradation	NN
cord-296347-fanlvxqs	324	18	substrates	substrate	NNS
cord-296347-fanlvxqs	324	19	from	from	IN
cord-296347-fanlvxqs	324	20	the	the	DT
cord-296347-fanlvxqs	324	21	ER	ER	NNP
cord-296347-fanlvxqs	324	22	membrane	membrane	NN
cord-296347-fanlvxqs	324	23	.	.	.
cord-296347-fanlvxqs	325	1	Hrd3p	Hrd3p	NNP
cord-296347-fanlvxqs	325	2	can	can	MD
cord-296347-fanlvxqs	325	3	associate	associate	VB
cord-296347-fanlvxqs	325	4	with	with	IN
cord-296347-fanlvxqs	325	5	Der1p	Der1p	NNS
cord-296347-fanlvxqs	325	6	,	,	,
cord-296347-fanlvxqs	325	7	presumably	presumably	RB
cord-296347-fanlvxqs	325	8	enabling	enable	VBG
cord-296347-fanlvxqs	325	9	substrate	substrate	JJ
cord-296347-fanlvxqs	325	10	delivery	delivery	NN
cord-296347-fanlvxqs	325	11	to	to	IN
cord-296347-fanlvxqs	325	12	downstream	downstream	JJ
cord-296347-fanlvxqs	325	13	components	component	NNS
cord-296347-fanlvxqs	325	14	.	.	.
cord-296347-fanlvxqs	326	1	Hrd3p	Hrd3p	NNP
cord-296347-fanlvxqs	326	2	can	can	MD
cord-296347-fanlvxqs	326	3	even	even	RB
cord-296347-fanlvxqs	326	4	regulate	regulate	VB
cord-296347-fanlvxqs	326	5	Hrd1p	hrd1p	IN
cord-296347-fanlvxqs	326	6	activity	activity	NN
cord-296347-fanlvxqs	326	7	,	,	,
cord-296347-fanlvxqs	326	8	which	which	WDT
cord-296347-fanlvxqs	326	9	is	be	VBZ
cord-296347-fanlvxqs	326	10	necessary	necessary	JJ
cord-296347-fanlvxqs	326	11	for	for	IN
cord-296347-fanlvxqs	326	12	substrate	substrate	JJ
cord-296347-fanlvxqs	326	13	extraction	extraction	NN
cord-296347-fanlvxqs	326	14	from	from	IN
cord-296347-fanlvxqs	326	15	the	the	DT
cord-296347-fanlvxqs	326	16	membrane	membrane	NN
cord-296347-fanlvxqs	326	17	and	and	CC
cord-296347-fanlvxqs	326	18	delivery	delivery	NN
cord-296347-fanlvxqs	326	19	to	to	IN
cord-296347-fanlvxqs	326	20	the	the	DT
cord-296347-fanlvxqs	326	21	proteasome	proteasome	NN
cord-296347-fanlvxqs	326	22	(	(	-LRB-
cord-296347-fanlvxqs	326	23	Gauss	Gauss	NNP
cord-296347-fanlvxqs	326	24	et	et	NNP
cord-296347-fanlvxqs	326	25	al	al	NNP
cord-296347-fanlvxqs	326	26	.	.	NNP
cord-296347-fanlvxqs	326	27	,	,	,
cord-296347-fanlvxqs	326	28	2006	2006	CD
cord-296347-fanlvxqs	326	29	)	)	-RRB-
cord-296347-fanlvxqs	327	1	(	(	-LRB-
cord-296347-fanlvxqs	327	2	Fig	Fig	NNP
cord-296347-fanlvxqs	327	3	.	.	.
cord-296347-fanlvxqs	327	4	3	3	CD
cord-296347-fanlvxqs	327	5	)	)	-RRB-
cord-296347-fanlvxqs	327	6	.	.	.
cord-296347-fanlvxqs	328	1	These	these	DT
cord-296347-fanlvxqs	328	2	multifunctional	multifunctional	JJ
cord-296347-fanlvxqs	328	3	protein	protein	NN
cord-296347-fanlvxqs	328	4	complexes	complex	NNS
cord-296347-fanlvxqs	328	5	can	can	MD
cord-296347-fanlvxqs	328	6	therefore	therefore	RB
cord-296347-fanlvxqs	328	7	function	function	VB
cord-296347-fanlvxqs	328	8	in	in	IN
cord-296347-fanlvxqs	328	9	substrate	substrate	NN
cord-296347-fanlvxqs	328	10	selection	selection	NN
cord-296347-fanlvxqs	328	11	in	in	IN
cord-296347-fanlvxqs	328	12	the	the	DT
cord-296347-fanlvxqs	328	13	ER	ER	NNP
cord-296347-fanlvxqs	328	14	lumen	lumen	NN
cord-296347-fanlvxqs	328	15	or	or	CC
cord-296347-fanlvxqs	328	16	membrane	membrane	NN
cord-296347-fanlvxqs	328	17	and	and	CC
cord-296347-fanlvxqs	328	18	even	even	RB
cord-296347-fanlvxqs	328	19	facilitate	facilitate	VB
cord-296347-fanlvxqs	328	20	subsequent	subsequent	JJ
cord-296347-fanlvxqs	328	21	steps	step	NNS
cord-296347-fanlvxqs	328	22	that	that	WDT
cord-296347-fanlvxqs	328	23	lead	lead	VBP
cord-296347-fanlvxqs	328	24	to	to	IN
cord-296347-fanlvxqs	328	25	proteasomal	proteasomal	JJ
cord-296347-fanlvxqs	328	26	degradation	degradation	NN
cord-296347-fanlvxqs	328	27	.	.	.
cord-296347-fanlvxqs	329	1	Similarly	similarly	RB
cord-296347-fanlvxqs	329	2	,	,	,
cord-296347-fanlvxqs	329	3	Doa10p	Doa10p	NNP
cord-296347-fanlvxqs	329	4	can	can	MD
cord-296347-fanlvxqs	329	5	catalyze	catalyze	VB
cord-296347-fanlvxqs	329	6	ubiquitination	ubiquitination	NN
cord-296347-fanlvxqs	329	7	of	of	IN
cord-296347-fanlvxqs	329	8	both	both	DT
cord-296347-fanlvxqs	329	9	membrane	membrane	NN
cord-296347-fanlvxqs	329	10	and	and	CC
cord-296347-fanlvxqs	329	11	soluble	soluble	JJ
cord-296347-fanlvxqs	329	12	proteins	protein	NNS
cord-296347-fanlvxqs	329	13	,	,	,
cord-296347-fanlvxqs	329	14	yet	yet	CC
cord-296347-fanlvxqs	329	15	the	the	DT
cord-296347-fanlvxqs	329	16	mechanisms	mechanism	NNS
cord-296347-fanlvxqs	329	17	of	of	IN
cord-296347-fanlvxqs	329	18	subsequent	subsequent	JJ
cord-296347-fanlvxqs	329	19	proteasome	proteasome	NN
cord-296347-fanlvxqs	329	20	targeting	targeting	NN
cord-296347-fanlvxqs	329	21	differ	differ	NNS
cord-296347-fanlvxqs	329	22	(	(	-LRB-
cord-296347-fanlvxqs	329	23	Ravid	Ravid	NNP
cord-296347-fanlvxqs	329	24	et	et	NNP
cord-296347-fanlvxqs	329	25	al	al	NNP
cord-296347-fanlvxqs	329	26	.	.	NNP
cord-296347-fanlvxqs	329	27	,	,	,
cord-296347-fanlvxqs	329	28	2006	2006	CD
cord-296347-fanlvxqs	329	29	)	)	-RRB-
cord-296347-fanlvxqs	329	30	,	,	,
cord-296347-fanlvxqs	329	31	presumably	presumably	RB
cord-296347-fanlvxqs	329	32	due	due	IN
cord-296347-fanlvxqs	329	33	to	to	IN
cord-296347-fanlvxqs	329	34	association	association	NN
cord-296347-fanlvxqs	329	35	with	with	IN
cord-296347-fanlvxqs	329	36	other	other	JJ
cord-296347-fanlvxqs	329	37	regulatory	regulatory	JJ
cord-296347-fanlvxqs	329	38	proteins	protein	NNS
cord-296347-fanlvxqs	329	39	.	.	.
cord-296347-fanlvxqs	330	1	The	the	DT
cord-296347-fanlvxqs	330	2	many	many	JJ
cord-296347-fanlvxqs	330	3	layers	layer	NNS
cord-296347-fanlvxqs	330	4	of	of	IN
cord-296347-fanlvxqs	330	5	E3mediated	e3mediate	VBN
cord-296347-fanlvxqs	330	6	regulation	regulation	NN
cord-296347-fanlvxqs	330	7	of	of	IN
cord-296347-fanlvxqs	330	8	ERAD	ERAD	NNP
cord-296347-fanlvxqs	330	9	substrate	substrate	NN
cord-296347-fanlvxqs	330	10	selection	selection	NN
cord-296347-fanlvxqs	330	11	are	be	VBP
cord-296347-fanlvxqs	330	12	most	most	RBS
cord-296347-fanlvxqs	330	13	likely	likely	RB
cord-296347-fanlvxqs	330	14	just	just	RB
cord-296347-fanlvxqs	330	15	emerging	emerge	VBG
cord-296347-fanlvxqs	330	16	.	.	.
cord-296347-fanlvxqs	331	1	In	in	IN
cord-296347-fanlvxqs	331	2	mammals	mammal	NNS
cord-296347-fanlvxqs	331	3	,	,	,
cord-296347-fanlvxqs	331	4	there	there	EX
cord-296347-fanlvxqs	331	5	are	be	VBP
cord-296347-fanlvxqs	331	6	two	two	CD
cord-296347-fanlvxqs	331	7	predicted	predict	VBN
cord-296347-fanlvxqs	331	8	homologues	homologue	NNS
cord-296347-fanlvxqs	331	9	of	of	IN
cord-296347-fanlvxqs	331	10	Hrd1p	Hrd1p	NNP
cord-296347-fanlvxqs	331	11	/	/	SYM
cord-296347-fanlvxqs	331	12	Der3p	Der3p	NNP
cord-296347-fanlvxqs	331	13	,	,	,
cord-296347-fanlvxqs	331	14	the	the	DT
cord-296347-fanlvxqs	331	15	HRD1	HRD1	NNP
cord-296347-fanlvxqs	331	16	and	and	CC
cord-296347-fanlvxqs	331	17	the	the	DT
cord-296347-fanlvxqs	331	18	gp78	gp78	NNP
cord-296347-fanlvxqs	331	19	E3	E3	NNP
cord-296347-fanlvxqs	331	20	ligases	ligase	NNS
cord-296347-fanlvxqs	331	21	.	.	.
cord-296347-fanlvxqs	332	1	Like	like	IN
cord-296347-fanlvxqs	332	2	its	-PRON-	PRP$
cord-296347-fanlvxqs	332	3	yeast	yeast	NN
cord-296347-fanlvxqs	332	4	counterpart	counterpart	NN
cord-296347-fanlvxqs	332	5	,	,	,
cord-296347-fanlvxqs	332	6	human	human	JJ
cord-296347-fanlvxqs	332	7	HRD1	HRD1	NNP
cord-296347-fanlvxqs	332	8	is	be	VBZ
cord-296347-fanlvxqs	332	9	involved	involve	VBN
cord-296347-fanlvxqs	332	10	in	in	IN
cord-296347-fanlvxqs	332	11	degradation	degradation	NN
cord-296347-fanlvxqs	332	12	from	from	IN
cord-296347-fanlvxqs	332	13	the	the	DT
cord-296347-fanlvxqs	332	14	ER	ER	NNP
cord-296347-fanlvxqs	332	15	(	(	-LRB-
cord-296347-fanlvxqs	332	16	Kikkert	Kikkert	NNP
cord-296347-fanlvxqs	332	17	et	et	NNP
cord-296347-fanlvxqs	332	18	al	al	NNP
cord-296347-fanlvxqs	332	19	.	.	NNP
cord-296347-fanlvxqs	332	20	,	,	,
cord-296347-fanlvxqs	332	21	2004	2004	CD
cord-296347-fanlvxqs	332	22	)	)	-RRB-
cord-296347-fanlvxqs	332	23	.	.	.
cord-296347-fanlvxqs	333	1	HRD1	HRD1	NNP
cord-296347-fanlvxqs	333	2	may	may	MD
cord-296347-fanlvxqs	333	3	associate	associate	VB
cord-296347-fanlvxqs	333	4	with	with	IN
cord-296347-fanlvxqs	333	5	UBC7	UBC7	NNP
cord-296347-fanlvxqs	333	6	to	to	TO
cord-296347-fanlvxqs	333	7	catalyze	catalyze	VB
cord-296347-fanlvxqs	333	8	ubiquitination	ubiquitination	NN
cord-296347-fanlvxqs	333	9	of	of	IN
cord-296347-fanlvxqs	333	10	a	a	DT
cord-296347-fanlvxqs	333	11	subset	subset	NN
cord-296347-fanlvxqs	333	12	of	of	IN
cord-296347-fanlvxqs	333	13	substrates	substrate	NNS
cord-296347-fanlvxqs	333	14	,	,	,
cord-296347-fanlvxqs	333	15	like	like	IN
cord-296347-fanlvxqs	333	16	TCRa	TCRa	NNP
cord-296347-fanlvxqs	333	17	and	and	CC
cord-296347-fanlvxqs	333	18	CD3d	CD3d	NNP
cord-296347-fanlvxqs	333	19	.	.	.
cord-296347-fanlvxqs	334	1	HRD1	HRD1	NNP
cord-296347-fanlvxqs	334	2	is	be	VBZ
cord-296347-fanlvxqs	334	3	not	not	RB
cord-296347-fanlvxqs	334	4	involved	involve	VBN
cord-296347-fanlvxqs	334	5	in	in	IN
cord-296347-fanlvxqs	334	6	the	the	DT
cord-296347-fanlvxqs	334	7	regulated	regulated	JJ
cord-296347-fanlvxqs	334	8	degradation	degradation	NN
cord-296347-fanlvxqs	334	9	of	of	IN
cord-296347-fanlvxqs	334	10	the	the	DT
cord-296347-fanlvxqs	334	11	mammalian	mammalian	JJ
cord-296347-fanlvxqs	334	12	HMGR	HMGR	NNP
cord-296347-fanlvxqs	335	1	(	(	-LRB-
cord-296347-fanlvxqs	335	2	Kikkert	Kikkert	NNP
cord-296347-fanlvxqs	335	3	et	et	NNP
cord-296347-fanlvxqs	335	4	al	al	NNP
cord-296347-fanlvxqs	335	5	.	.	NNP
cord-296347-fanlvxqs	335	6	,	,	,
cord-296347-fanlvxqs	335	7	2004	2004	CD
cord-296347-fanlvxqs	335	8	)	)	-RRB-
cord-296347-fanlvxqs	335	9	.	.	.
cord-296347-fanlvxqs	336	1	HRD1	HRD1	NNP
cord-296347-fanlvxqs	336	2	may	may	MD
cord-296347-fanlvxqs	336	3	also	also	RB
cord-296347-fanlvxqs	336	4	associate	associate	VB
cord-296347-fanlvxqs	336	5	with	with	IN
cord-296347-fanlvxqs	336	6	SEL1L	SEL1L	NNP
cord-296347-fanlvxqs	336	7	,	,	,
cord-296347-fanlvxqs	336	8	a	a	DT
cord-296347-fanlvxqs	336	9	homologue	homologue	NN
cord-296347-fanlvxqs	336	10	of	of	IN
cord-296347-fanlvxqs	336	11	Hrd3p	Hrd3p	NNP
cord-296347-fanlvxqs	336	12	,	,	,
cord-296347-fanlvxqs	336	13	as	as	RB
cord-296347-fanlvxqs	336	14	well	well	RB
cord-296347-fanlvxqs	336	15	as	as	IN
cord-296347-fanlvxqs	336	16	other	other	JJ
cord-296347-fanlvxqs	336	17	ER	ER	NNP
cord-296347-fanlvxqs	336	18	membrane	membrane	NN
cord-296347-fanlvxqs	336	19	and	and	CC
cord-296347-fanlvxqs	336	20	ER	ER	NNP
cord-296347-fanlvxqs	336	21	membrane	membrane	NN
cord-296347-fanlvxqs	336	22	-	-	HYPH
cord-296347-fanlvxqs	336	23	associated	associate	VBN
cord-296347-fanlvxqs	336	24	proteins	protein	NNS
cord-296347-fanlvxqs	336	25	,	,	,
cord-296347-fanlvxqs	336	26	including	include	VBG
cord-296347-fanlvxqs	336	27	Cdc48p(p97)/NPL4	Cdc48p(p97)/NPL4	NNP
cord-296347-fanlvxqs	336	28	/	/	SYM
cord-296347-fanlvxqs	336	29	UFD1	UFD1	NNP
cord-296347-fanlvxqs	336	30	,	,	,
cord-296347-fanlvxqs	336	31	forming	form	VBG
cord-296347-fanlvxqs	336	32	multisubunit	multisubunit	NN
cord-296347-fanlvxqs	336	33	complexes	complex	NNS
cord-296347-fanlvxqs	336	34	that	that	WDT
cord-296347-fanlvxqs	336	35	seem	seem	VBP
cord-296347-fanlvxqs	336	36	to	to	TO
cord-296347-fanlvxqs	336	37	coordinate	coordinate	VB
cord-296347-fanlvxqs	336	38	steps	step	NNS
cord-296347-fanlvxqs	336	39	that	that	WDT
cord-296347-fanlvxqs	336	40	range	range	VBP
cord-296347-fanlvxqs	336	41	from	from	IN
cord-296347-fanlvxqs	336	42	substrate	substrate	NN
cord-296347-fanlvxqs	336	43	selection	selection	NN
cord-296347-fanlvxqs	336	44	to	to	IN
cord-296347-fanlvxqs	336	45	delivery	delivery	NN
cord-296347-fanlvxqs	336	46	to	to	IN
cord-296347-fanlvxqs	336	47	the	the	DT
cord-296347-fanlvxqs	336	48	proteasome	proteasome	NN
cord-296347-fanlvxqs	336	49	for	for	IN
cord-296347-fanlvxqs	336	50	at	at	IN
cord-296347-fanlvxqs	336	51	least	least	JJS
cord-296347-fanlvxqs	336	52	a	a	DT
cord-296347-fanlvxqs	336	53	subset	subset	NN
cord-296347-fanlvxqs	336	54	of	of	IN
cord-296347-fanlvxqs	336	55	ER	ER	NNP
cord-296347-fanlvxqs	336	56	degradation	degradation	NN
cord-296347-fanlvxqs	336	57	substrates	substrate	NNS
cord-296347-fanlvxqs	336	58	(	(	-LRB-
cord-296347-fanlvxqs	336	59	Lilley	Lilley	NNP
cord-296347-fanlvxqs	336	60	and	and	CC
cord-296347-fanlvxqs	336	61	Ploegh	Ploegh	NNP
cord-296347-fanlvxqs	336	62	,	,	,
cord-296347-fanlvxqs	336	63	2005a	2005a	CD
cord-296347-fanlvxqs	336	64	;	;	:
cord-296347-fanlvxqs	336	65	Ye	Ye	NNP
cord-296347-fanlvxqs	336	66	et	et	NNP
cord-296347-fanlvxqs	336	67	al	al	NNP
cord-296347-fanlvxqs	336	68	.	.	NNP
cord-296347-fanlvxqs	336	69	,	,	,
cord-296347-fanlvxqs	336	70	2005	2005	CD
cord-296347-fanlvxqs	336	71	)	)	-RRB-
cord-296347-fanlvxqs	336	72	.	.	.
cord-296347-fanlvxqs	337	1	gp78	gp78	NNP
cord-296347-fanlvxqs	337	2	was	be	VBD
cord-296347-fanlvxqs	337	3	identified	identify	VBN
cord-296347-fanlvxqs	337	4	as	as	IN
cord-296347-fanlvxqs	337	5	the	the	DT
cord-296347-fanlvxqs	337	6	tumor	tumor	NN
cord-296347-fanlvxqs	337	7	autocrine	autocrine	NN
cord-296347-fanlvxqs	337	8	motility	motility	NN
cord-296347-fanlvxqs	337	9	factor	factor	NN
cord-296347-fanlvxqs	337	10	receptor	receptor	NN
cord-296347-fanlvxqs	337	11	(	(	-LRB-
cord-296347-fanlvxqs	337	12	AMFR	AMFR	NNP
cord-296347-fanlvxqs	337	13	)	)	-RRB-
cord-296347-fanlvxqs	338	1	(	(	-LRB-
cord-296347-fanlvxqs	338	2	Nabi	Nabi	NNP
cord-296347-fanlvxqs	338	3	et	et	NNP
cord-296347-fanlvxqs	338	4	al	al	NNP
cord-296347-fanlvxqs	338	5	.	.	NNP
cord-296347-fanlvxqs	338	6	,	,	,
cord-296347-fanlvxqs	338	7	1992	1992	CD
cord-296347-fanlvxqs	338	8	)	)	-RRB-
cord-296347-fanlvxqs	338	9	and	and	CC
cord-296347-fanlvxqs	338	10	later	later	RB
cord-296347-fanlvxqs	338	11	as	as	IN
cord-296347-fanlvxqs	338	12	an	an	DT
cord-296347-fanlvxqs	338	13	E3	e3	NN
cord-296347-fanlvxqs	338	14	ligase	ligase	NN
cord-296347-fanlvxqs	338	15	due	due	IN
cord-296347-fanlvxqs	338	16	to	to	IN
cord-296347-fanlvxqs	338	17	its	-PRON-	PRP$
cord-296347-fanlvxqs	338	18	homology	homology	NN
cord-296347-fanlvxqs	338	19	to	to	IN
cord-296347-fanlvxqs	338	20	Hrd1p	hrd1p	NN
cord-296347-fanlvxqs	338	21	and	and	CC
cord-296347-fanlvxqs	338	22	involvement	involvement	NN
cord-296347-fanlvxqs	338	23	in	in	IN
cord-296347-fanlvxqs	338	24	degradation	degradation	NN
cord-296347-fanlvxqs	338	25	of	of	IN
cord-296347-fanlvxqs	338	26	CD3d	CD3d	NNP
cord-296347-fanlvxqs	338	27	and	and	CC
cord-296347-fanlvxqs	338	28	apoliprotein	apoliprotein	NNP
cord-296347-fanlvxqs	338	29	B100	B100	NNP
cord-296347-fanlvxqs	339	1	(	(	-LRB-
cord-296347-fanlvxqs	339	2	Fang	Fang	NNP
cord-296347-fanlvxqs	339	3	et	et	FW
cord-296347-fanlvxqs	339	4	al	al	NNP
cord-296347-fanlvxqs	339	5	.	.	NNP
cord-296347-fanlvxqs	339	6	,	,	,
cord-296347-fanlvxqs	339	7	2001	2001	CD
cord-296347-fanlvxqs	339	8	;	;	:
cord-296347-fanlvxqs	339	9	Liang	Liang	NNP
cord-296347-fanlvxqs	339	10	et	et	NNP
cord-296347-fanlvxqs	339	11	al	al	NNP
cord-296347-fanlvxqs	339	12	.	.	NNP
cord-296347-fanlvxqs	339	13	,	,	,
cord-296347-fanlvxqs	339	14	2003	2003	CD
cord-296347-fanlvxqs	339	15	)	)	-RRB-
cord-296347-fanlvxqs	339	16	.	.	.
cord-296347-fanlvxqs	340	1	gp78	gp78	NNP
cord-296347-fanlvxqs	340	2	is	be	VBZ
cord-296347-fanlvxqs	340	3	an	an	DT
cord-296347-fanlvxqs	340	4	ER	ER	NNP
cord-296347-fanlvxqs	340	5	-	-	HYPH
cord-296347-fanlvxqs	340	6	resident	resident	JJ
cord-296347-fanlvxqs	340	7	protein	protein	NN
cord-296347-fanlvxqs	340	8	,	,	,
cord-296347-fanlvxqs	340	9	predicted	predict	VBD
cord-296347-fanlvxqs	340	10	to	to	TO
cord-296347-fanlvxqs	340	11	span	span	VB
cord-296347-fanlvxqs	340	12	the	the	DT
cord-296347-fanlvxqs	340	13	membrane	membrane	NN
cord-296347-fanlvxqs	340	14	five	five	CD
cord-296347-fanlvxqs	340	15	times	time	NNS
cord-296347-fanlvxqs	340	16	,	,	,
cord-296347-fanlvxqs	340	17	with	with	IN
cord-296347-fanlvxqs	340	18	a	a	DT
cord-296347-fanlvxqs	340	19	C	c	NN
cord-296347-fanlvxqs	340	20	-	-	HYPH
cord-296347-fanlvxqs	340	21	terminal	terminal	NN
cord-296347-fanlvxqs	340	22	cytosolic	cytosolic	JJ
cord-296347-fanlvxqs	340	23	RING	ring	NN
cord-296347-fanlvxqs	340	24	-	-	HYPH
cord-296347-fanlvxqs	340	25	domain	domain	NN
cord-296347-fanlvxqs	340	26	and	and	CC
cord-296347-fanlvxqs	340	27	an	an	DT
cord-296347-fanlvxqs	340	28	additional	additional	JJ
cord-296347-fanlvxqs	340	29	UBC7	UBC7	NNP
cord-296347-fanlvxqs	340	30	E2-binding	e2-binding	NN
cord-296347-fanlvxqs	340	31	site	site	NN
cord-296347-fanlvxqs	340	32	,	,	,
cord-296347-fanlvxqs	340	33	the	the	DT
cord-296347-fanlvxqs	340	34	Cue	Cue	NNP
cord-296347-fanlvxqs	340	35	domain	domain	NN
cord-296347-fanlvxqs	340	36	,	,	,
cord-296347-fanlvxqs	340	37	arranged	arrange	VBN
cord-296347-fanlvxqs	340	38	in	in	IN
cord-296347-fanlvxqs	340	39	tandem	tandem	NN
cord-296347-fanlvxqs	340	40	.	.	.
cord-296347-fanlvxqs	341	1	While	while	IN
cord-296347-fanlvxqs	341	2	Hrd1p	Hrd1p	NNP
cord-296347-fanlvxqs	341	3	recruits	recruit	VBZ
cord-296347-fanlvxqs	341	4	UBC7	UBC7	NNP
cord-296347-fanlvxqs	341	5	through	through	IN
cord-296347-fanlvxqs	341	6	the	the	DT
cord-296347-fanlvxqs	341	7	transmembrane	transmembrane	NNP
cord-296347-fanlvxqs	341	8	Cue1p	Cue1p	NNP
cord-296347-fanlvxqs	341	9	protein	protein	NN
cord-296347-fanlvxqs	341	10	,	,	,
cord-296347-fanlvxqs	341	11	it	-PRON-	PRP
cord-296347-fanlvxqs	341	12	seems	seem	VBZ
cord-296347-fanlvxqs	341	13	that	that	IN
cord-296347-fanlvxqs	341	14	convergent	convergent	JJ
cord-296347-fanlvxqs	341	15	evolution	evolution	NN
cord-296347-fanlvxqs	341	16	has	have	VBZ
cord-296347-fanlvxqs	341	17	made	make	VBN
cord-296347-fanlvxqs	341	18	the	the	DT
cord-296347-fanlvxqs	341	19	E3-and	e3-and	NN
cord-296347-fanlvxqs	342	1	the	the	DT
cord-296347-fanlvxqs	342	2	E2-docking	e2-docke	VBG
cord-296347-fanlvxqs	342	3	protein	protein	NN
cord-296347-fanlvxqs	342	4	come	come	VB
cord-296347-fanlvxqs	342	5	together	together	RB
cord-296347-fanlvxqs	342	6	in	in	IN
cord-296347-fanlvxqs	342	7	a	a	DT
cord-296347-fanlvxqs	342	8	single	single	JJ
cord-296347-fanlvxqs	342	9	human	human	JJ
cord-296347-fanlvxqs	342	10	protein	protein	NN
cord-296347-fanlvxqs	342	11	.	.	.
cord-296347-fanlvxqs	343	1	Curiously	curiously	RB
cord-296347-fanlvxqs	343	2	,	,	,
cord-296347-fanlvxqs	343	3	gp78	gp78	NNP
cord-296347-fanlvxqs	343	4	is	be	VBZ
cord-296347-fanlvxqs	343	5	involved	involve	VBN
cord-296347-fanlvxqs	343	6	in	in	IN
cord-296347-fanlvxqs	343	7	sterol	sterol	NN
cord-296347-fanlvxqs	343	8	-	-	HYPH
cord-296347-fanlvxqs	343	9	regulated	regulate	VBN
cord-296347-fanlvxqs	343	10	Ub	Ub	NNP
cord-296347-fanlvxqs	343	11	-	-	HYPH
cord-296347-fanlvxqs	343	12	dependent	dependent	JJ
cord-296347-fanlvxqs	343	13	degradation	degradation	NN
cord-296347-fanlvxqs	343	14	of	of	IN
cord-296347-fanlvxqs	343	15	HMGR	HMGR	NNP
cord-296347-fanlvxqs	344	1	(	(	-LRB-
cord-296347-fanlvxqs	344	2	Song	Song	NNP
cord-296347-fanlvxqs	344	3	et	et	FW
cord-296347-fanlvxqs	344	4	al	al	NNP
cord-296347-fanlvxqs	344	5	.	.	NNP
cord-296347-fanlvxqs	344	6	,	,	,
cord-296347-fanlvxqs	344	7	2005	2005	CD
cord-296347-fanlvxqs	344	8	)	)	-RRB-
cord-296347-fanlvxqs	344	9	,	,	,
cord-296347-fanlvxqs	344	10	suggesting	suggest	VBG
cord-296347-fanlvxqs	344	11	it	-PRON-	PRP
cord-296347-fanlvxqs	344	12	constitutes	constitute	VBZ
cord-296347-fanlvxqs	344	13	the	the	DT
cord-296347-fanlvxqs	344	14	true	true	JJ
cord-296347-fanlvxqs	344	15	functional	functional	JJ
cord-296347-fanlvxqs	344	16	homologue	homologue	NN
cord-296347-fanlvxqs	344	17	of	of	IN
cord-296347-fanlvxqs	344	18	yeast	yeast	NN
cord-296347-fanlvxqs	344	19	Hrd1p	Hrd1p	NNP
cord-296347-fanlvxqs	344	20	.	.	.
cord-296347-fanlvxqs	345	1	Homocysteine	Homocysteine	NNP
cord-296347-fanlvxqs	345	2	-	-	HYPH
cord-296347-fanlvxqs	345	3	induced	induce	VBN
cord-296347-fanlvxqs	345	4	endoplasmic	endoplasmic	NN
cord-296347-fanlvxqs	345	5	reticulum	reticulum	NN
cord-296347-fanlvxqs	345	6	protein	protein	NN
cord-296347-fanlvxqs	345	7	(	(	-LRB-
cord-296347-fanlvxqs	345	8	HERP	HERP	NNP
cord-296347-fanlvxqs	345	9	)	)	-RRB-
cord-296347-fanlvxqs	345	10	is	be	VBZ
cord-296347-fanlvxqs	345	11	a	a	DT
cord-296347-fanlvxqs	345	12	singlespanning	singlespanning	NN
cord-296347-fanlvxqs	345	13	ER	er	NN
cord-296347-fanlvxqs	345	14	membrane	membrane	NN
cord-296347-fanlvxqs	345	15	protein	protein	NN
cord-296347-fanlvxqs	345	16	that	that	WDT
cord-296347-fanlvxqs	345	17	is	be	VBZ
cord-296347-fanlvxqs	345	18	induced	induce	VBN
cord-296347-fanlvxqs	345	19	by	by	IN
cord-296347-fanlvxqs	345	20	the	the	DT
cord-296347-fanlvxqs	345	21	unfolded	unfold	VBN
cord-296347-fanlvxqs	345	22	protein	protein	NN
cord-296347-fanlvxqs	345	23	response	response	NN
cord-296347-fanlvxqs	345	24	(	(	-LRB-
cord-296347-fanlvxqs	345	25	UPR	UPR	NNP
cord-296347-fanlvxqs	345	26	)	)	-RRB-
cord-296347-fanlvxqs	345	27	and	and	CC
cord-296347-fanlvxqs	345	28	also	also	RB
cord-296347-fanlvxqs	345	29	required	require	VBN
cord-296347-fanlvxqs	345	30	for	for	IN
cord-296347-fanlvxqs	345	31	ERAD	ERAD	NNP
cord-296347-fanlvxqs	345	32	.	.	.
cord-296347-fanlvxqs	346	1	HERP	HERP	NNP
cord-296347-fanlvxqs	346	2	is	be	VBZ
cord-296347-fanlvxqs	346	3	proposed	propose	VBN
cord-296347-fanlvxqs	346	4	to	to	TO
cord-296347-fanlvxqs	346	5	improve	improve	VB
cord-296347-fanlvxqs	346	6	ER	ER	NNP
cord-296347-fanlvxqs	346	7	protein	protein	NN
cord-296347-fanlvxqs	346	8	folding	folding	NN
cord-296347-fanlvxqs	346	9	and	and	CC
cord-296347-fanlvxqs	346	10	decrease	decrease	VB
cord-296347-fanlvxqs	346	11	protein	protein	NN
cord-296347-fanlvxqs	346	12	load	load	NN
cord-296347-fanlvxqs	346	13	,	,	,
cord-296347-fanlvxqs	346	14	protecting	protect	VBG
cord-296347-fanlvxqs	346	15	cells	cell	NNS
cord-296347-fanlvxqs	346	16	from	from	IN
cord-296347-fanlvxqs	346	17	ER	er	NN
cord-296347-fanlvxqs	346	18	-	-	HYPH
cord-296347-fanlvxqs	346	19	stress	stress	NN
cord-296347-fanlvxqs	346	20	-	-	HYPH
cord-296347-fanlvxqs	346	21	induced	induce	VBN
cord-296347-fanlvxqs	346	22	apoptosis	apoptosis	NN
cord-296347-fanlvxqs	347	1	(	(	-LRB-
cord-296347-fanlvxqs	347	2	Kokame	Kokame	NNP
cord-296347-fanlvxqs	347	3	et	et	FW
cord-296347-fanlvxqs	347	4	al	al	NNP
cord-296347-fanlvxqs	347	5	.	.	NNP
cord-296347-fanlvxqs	347	6	,	,	,
cord-296347-fanlvxqs	347	7	2000	2000	CD
cord-296347-fanlvxqs	347	8	)	)	-RRB-
cord-296347-fanlvxqs	347	9	.	.	.
cord-296347-fanlvxqs	348	1	Furthermore	furthermore	RB
cord-296347-fanlvxqs	348	2	,	,	,
cord-296347-fanlvxqs	348	3	HERP	HERP	NNP
cord-296347-fanlvxqs	348	4	has	have	VBZ
cord-296347-fanlvxqs	348	5	an	an	DT
cord-296347-fanlvxqs	348	6	N	n	CD
cord-296347-fanlvxqs	348	7	-	-	HYPH
cord-296347-fanlvxqs	348	8	terminal	terminal	NN
cord-296347-fanlvxqs	348	9	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	348	10	-	-	HYPH
cord-296347-fanlvxqs	348	11	like	like	JJ
cord-296347-fanlvxqs	348	12	domain	domain	NN
cord-296347-fanlvxqs	348	13	(	(	-LRB-
cord-296347-fanlvxqs	348	14	ULD	ULD	NNP
cord-296347-fanlvxqs	348	15	)	)	-RRB-
cord-296347-fanlvxqs	348	16	and	and	CC
cord-296347-fanlvxqs	348	17	is	be	VBZ
cord-296347-fanlvxqs	348	18	required	require	VBN
cord-296347-fanlvxqs	348	19	for	for	IN
cord-296347-fanlvxqs	348	20	the	the	DT
cord-296347-fanlvxqs	348	21	degradation	degradation	NN
cord-296347-fanlvxqs	348	22	of	of	IN
cord-296347-fanlvxqs	348	23	conexin	conexin	NN
cord-296347-fanlvxqs	348	24	and	and	CC
cord-296347-fanlvxqs	348	25	CD3d	CD3d	NNP
cord-296347-fanlvxqs	348	26	(	(	-LRB-
cord-296347-fanlvxqs	348	27	Hori	Hori	NNP
cord-296347-fanlvxqs	348	28	et	et	NNP
cord-296347-fanlvxqs	348	29	al	al	NNP
cord-296347-fanlvxqs	348	30	.	.	NNP
cord-296347-fanlvxqs	348	31	,	,	,
cord-296347-fanlvxqs	348	32	2004	2004	CD
cord-296347-fanlvxqs	348	33	;	;	:
cord-296347-fanlvxqs	348	34	Sai	Sai	NNP
cord-296347-fanlvxqs	348	35	et	et	FW
cord-296347-fanlvxqs	348	36	al	al	NNP
cord-296347-fanlvxqs	348	37	.	.	NNP
cord-296347-fanlvxqs	348	38	,	,	,
cord-296347-fanlvxqs	348	39	2002	2002	CD
cord-296347-fanlvxqs	348	40	)	)	-RRB-
cord-296347-fanlvxqs	348	41	.	.	.
cord-296347-fanlvxqs	349	1	It	-PRON-	PRP
cord-296347-fanlvxqs	349	2	forms	form	VBZ
cord-296347-fanlvxqs	349	3	a	a	DT
cord-296347-fanlvxqs	349	4	complex	complex	NN
cord-296347-fanlvxqs	349	5	with	with	IN
cord-296347-fanlvxqs	349	6	HRD1	HRD1	NNP
cord-296347-fanlvxqs	349	7	,	,	,
cord-296347-fanlvxqs	349	8	p97	p97	CD
cord-296347-fanlvxqs	349	9	,	,	,
cord-296347-fanlvxqs	349	10	Derlin-1	Derlin-1	NNP
cord-296347-fanlvxqs	349	11	,	,	,
cord-296347-fanlvxqs	349	12	and	and	CC
cord-296347-fanlvxqs	349	13	VIMP	VIMP	NNP
cord-296347-fanlvxqs	350	1	(	(	-LRB-
cord-296347-fanlvxqs	350	2	Schulze	Schulze	NNP
cord-296347-fanlvxqs	350	3	et	et	NNP
cord-296347-fanlvxqs	350	4	al	al	NNP
cord-296347-fanlvxqs	350	5	.	.	NNP
cord-296347-fanlvxqs	350	6	,	,	,
cord-296347-fanlvxqs	350	7	2005	2005	CD
cord-296347-fanlvxqs	350	8	)	)	-RRB-
cord-296347-fanlvxqs	350	9	,	,	,
cord-296347-fanlvxqs	350	10	a	a	DT
cord-296347-fanlvxqs	350	11	VCP	vcp	NN
cord-296347-fanlvxqs	350	12	(	(	-LRB-
cord-296347-fanlvxqs	350	13	p97)-interacting	p97)-interacte	VBG
cord-296347-fanlvxqs	350	14	membrane	membrane	NN
cord-296347-fanlvxqs	350	15	protein	protein	NN
cord-296347-fanlvxqs	350	16	,	,	,
cord-296347-fanlvxqs	350	17	that	that	WDT
cord-296347-fanlvxqs	350	18	recruits	recruit	VBZ
cord-296347-fanlvxqs	350	19	p97	p97	CD
cord-296347-fanlvxqs	350	20	to	to	IN
cord-296347-fanlvxqs	350	21	Derlin-1	Derlin-1	NNP
cord-296347-fanlvxqs	350	22	(	(	-LRB-
cord-296347-fanlvxqs	350	23	Ye	Ye	NNP
cord-296347-fanlvxqs	350	24	et	et	FW
cord-296347-fanlvxqs	350	25	al	al	NNP
cord-296347-fanlvxqs	350	26	.	.	NNP
cord-296347-fanlvxqs	350	27	,	,	,
cord-296347-fanlvxqs	350	28	2004	2004	CD
cord-296347-fanlvxqs	350	29	)	)	-RRB-
cord-296347-fanlvxqs	350	30	.	.	.
cord-296347-fanlvxqs	351	1	HERP	HERP	NNP
cord-296347-fanlvxqs	351	2	may	may	MD
cord-296347-fanlvxqs	351	3	function	function	VB
cord-296347-fanlvxqs	351	4	as	as	IN
cord-296347-fanlvxqs	351	5	another	another	DT
cord-296347-fanlvxqs	351	6	adaptor	adaptor	NN
cord-296347-fanlvxqs	351	7	protein	protein	NN
cord-296347-fanlvxqs	351	8	in	in	IN
cord-296347-fanlvxqs	351	9	these	these	DT
cord-296347-fanlvxqs	351	10	multiprotein	multiprotein	NNP
cord-296347-fanlvxqs	351	11	complexes	complex	NNS
cord-296347-fanlvxqs	351	12	at	at	IN
cord-296347-fanlvxqs	351	13	the	the	DT
cord-296347-fanlvxqs	351	14	ER	ER	NNP
cord-296347-fanlvxqs	351	15	membrane	membrane	NN
cord-296347-fanlvxqs	351	16	,	,	,
cord-296347-fanlvxqs	351	17	influencing	influence	VBG
cord-296347-fanlvxqs	351	18	substrate	substrate	NN
cord-296347-fanlvxqs	351	19	selection	selection	NN
cord-296347-fanlvxqs	351	20	.	.	.
cord-296347-fanlvxqs	352	1	The	the	DT
cord-296347-fanlvxqs	352	2	Doa10p	doa10p	CD
cord-296347-fanlvxqs	352	3	mammalian	mammalian	JJ
cord-296347-fanlvxqs	352	4	homologue	homologue	NN
cord-296347-fanlvxqs	352	5	,	,	,
cord-296347-fanlvxqs	352	6	TEB4	TEB4	NNP
cord-296347-fanlvxqs	352	7	(	(	-LRB-
cord-296347-fanlvxqs	352	8	or	or	CC
cord-296347-fanlvxqs	352	9	MARCH	MARCH	NNP
cord-296347-fanlvxqs	352	10	-	-	HYPH
cord-296347-fanlvxqs	352	11	VI	VI	NNP
cord-296347-fanlvxqs	352	12	)	)	-RRB-
cord-296347-fanlvxqs	352	13	,	,	,
cord-296347-fanlvxqs	352	14	is	be	VBZ
cord-296347-fanlvxqs	352	15	a	a	DT
cord-296347-fanlvxqs	352	16	multipletransmembrane	multipletransmembrane	NN
cord-296347-fanlvxqs	352	17	-	-	HYPH
cord-296347-fanlvxqs	352	18	domain	domain	NN
cord-296347-fanlvxqs	352	19	-	-	HYPH
cord-296347-fanlvxqs	352	20	containing	contain	VBG
cord-296347-fanlvxqs	352	21	protein	protein	NN
cord-296347-fanlvxqs	352	22	of	of	IN
cord-296347-fanlvxqs	352	23	the	the	DT
cord-296347-fanlvxqs	352	24	ER	ER	NNP
cord-296347-fanlvxqs	352	25	membrane	membrane	NN
cord-296347-fanlvxqs	352	26	that	that	WDT
cord-296347-fanlvxqs	352	27	functions	function	VBZ
cord-296347-fanlvxqs	352	28	as	as	IN
cord-296347-fanlvxqs	352	29	an	an	DT
cord-296347-fanlvxqs	352	30	E3	e3	NN
cord-296347-fanlvxqs	352	31	ligase	ligase	NN
cord-296347-fanlvxqs	352	32	:	:	:
cord-296347-fanlvxqs	352	33	it	-PRON-	PRP
cord-296347-fanlvxqs	352	34	has	have	VBZ
cord-296347-fanlvxqs	352	35	an	an	DT
cord-296347-fanlvxqs	352	36	N	n	CD
cord-296347-fanlvxqs	352	37	-	-	HYPH
cord-296347-fanlvxqs	352	38	terminal	terminal	JJ
cord-296347-fanlvxqs	352	39	noncanonical	noncanonical	JJ
cord-296347-fanlvxqs	352	40	RING	ring	NN
cord-296347-fanlvxqs	352	41	-	-	HYPH
cord-296347-fanlvxqs	352	42	domain	domain	NN
cord-296347-fanlvxqs	352	43	in	in	IN
cord-296347-fanlvxqs	352	44	the	the	DT
cord-296347-fanlvxqs	352	45	cytosol	cytosol	NN
cord-296347-fanlvxqs	352	46	that	that	WDT
cord-296347-fanlvxqs	352	47	catalyzes	catalyze	VBZ
cord-296347-fanlvxqs	352	48	Ub	ub	JJ
cord-296347-fanlvxqs	352	49	conjugation	conjugation	NN
cord-296347-fanlvxqs	352	50	and	and	CC
cord-296347-fanlvxqs	352	51	TEB4	TEB4	NNP
cord-296347-fanlvxqs	352	52	self	self	NN
cord-296347-fanlvxqs	352	53	-	-	HYPH
cord-296347-fanlvxqs	352	54	ubiquitination	ubiquitination	NN
cord-296347-fanlvxqs	352	55	and	and	CC
cord-296347-fanlvxqs	352	56	degradation	degradation	NN
cord-296347-fanlvxqs	353	1	(	(	-LRB-
cord-296347-fanlvxqs	353	2	Hassink	Hassink	NNP
cord-296347-fanlvxqs	353	3	et	et	NNP
cord-296347-fanlvxqs	353	4	al	al	NNP
cord-296347-fanlvxqs	353	5	.	.	NNP
cord-296347-fanlvxqs	353	6	,	,	,
cord-296347-fanlvxqs	353	7	2005	2005	CD
cord-296347-fanlvxqs	353	8	)	)	-RRB-
cord-296347-fanlvxqs	353	9	,	,	,
cord-296347-fanlvxqs	353	10	but	but	CC
cord-296347-fanlvxqs	353	11	its	-PRON-	PRP$
cord-296347-fanlvxqs	353	12	regulation	regulation	NN
cord-296347-fanlvxqs	353	13	is	be	VBZ
cord-296347-fanlvxqs	353	14	poorly	poorly	RB
cord-296347-fanlvxqs	353	15	characterized	characterize	VBN
cord-296347-fanlvxqs	353	16	.	.	.
cord-296347-fanlvxqs	354	1	Parkin	Parkin	NNP
cord-296347-fanlvxqs	354	2	is	be	VBZ
cord-296347-fanlvxqs	354	3	a	a	DT
cord-296347-fanlvxqs	354	4	cytosolic	cytosolic	JJ
cord-296347-fanlvxqs	354	5	E3	e3	NN
cord-296347-fanlvxqs	354	6	ligase	ligase	NN
cord-296347-fanlvxqs	354	7	with	with	IN
cord-296347-fanlvxqs	354	8	a	a	DT
cord-296347-fanlvxqs	354	9	C	c	NN
cord-296347-fanlvxqs	354	10	-	-	HYPH
cord-296347-fanlvxqs	354	11	terminal	terminal	NN
cord-296347-fanlvxqs	354	12	noncanonical	noncanonical	JJ
cord-296347-fanlvxqs	354	13	double	double	JJ
cord-296347-fanlvxqs	354	14	-	-	HYPH
cord-296347-fanlvxqs	354	15	RING	ring	NN
cord-296347-fanlvxqs	354	16	-	-	HYPH
cord-296347-fanlvxqs	354	17	finger	finger	NN
cord-296347-fanlvxqs	354	18	(	(	-LRB-
cord-296347-fanlvxqs	354	19	RING	ring	NN
cord-296347-fanlvxqs	354	20	-	-	HYPH
cord-296347-fanlvxqs	354	21	IBR	ibr	NN
cord-296347-fanlvxqs	354	22	-	-	HYPH
cord-296347-fanlvxqs	354	23	RING	ring	NN
cord-296347-fanlvxqs	354	24	)	)	-RRB-
cord-296347-fanlvxqs	354	25	,	,	,
cord-296347-fanlvxqs	354	26	and	and	CC
cord-296347-fanlvxqs	354	27	an	an	DT
cord-296347-fanlvxqs	354	28	N	n	CD
cord-296347-fanlvxqs	354	29	-	-	HYPH
cord-296347-fanlvxqs	354	30	terminal	terminal	JJ
cord-296347-fanlvxqs	354	31	Ub	Ub	NNP
cord-296347-fanlvxqs	354	32	-	-	HYPH
cord-296347-fanlvxqs	354	33	binding	bind	VBG
cord-296347-fanlvxqs	354	34	domain	domain	NN
cord-296347-fanlvxqs	354	35	,	,	,
cord-296347-fanlvxqs	354	36	believed	believe	VBN
cord-296347-fanlvxqs	354	37	to	to	TO
cord-296347-fanlvxqs	354	38	mediate	mediate	VB
cord-296347-fanlvxqs	354	39	proteasomal	proteasomal	JJ
cord-296347-fanlvxqs	354	40	degradation	degradation	NN
cord-296347-fanlvxqs	354	41	of	of	IN
cord-296347-fanlvxqs	354	42	aggregation	aggregation	NN
cord-296347-fanlvxqs	354	43	-	-	HYPH
cord-296347-fanlvxqs	354	44	prone	prone	JJ
cord-296347-fanlvxqs	354	45	proteins	protein	NNS
cord-296347-fanlvxqs	354	46	(	(	-LRB-
cord-296347-fanlvxqs	354	47	Imai	Imai	NNP
cord-296347-fanlvxqs	354	48	et	et	NNP
cord-296347-fanlvxqs	354	49	al	al	NNP
cord-296347-fanlvxqs	354	50	.	.	NNP
cord-296347-fanlvxqs	354	51	,	,	,
cord-296347-fanlvxqs	354	52	2000	2000	CD
cord-296347-fanlvxqs	354	53	)	)	-RRB-
cord-296347-fanlvxqs	354	54	,	,	,
cord-296347-fanlvxqs	354	55	typical	typical	JJ
cord-296347-fanlvxqs	354	56	of	of	IN
cord-296347-fanlvxqs	354	57	Parkinson	Parkinson	NNP
cord-296347-fanlvxqs	354	58	's	's	POS
cord-296347-fanlvxqs	354	59	disease	disease	NN
cord-296347-fanlvxqs	354	60	.	.	.
cord-296347-fanlvxqs	355	1	Both	both	DT
cord-296347-fanlvxqs	355	2	phosphorylation	phosphorylation	NN
cord-296347-fanlvxqs	356	1	(	(	-LRB-
cord-296347-fanlvxqs	356	2	Yamamoto	Yamamoto	NNP
cord-296347-fanlvxqs	356	3	et	et	NNP
cord-296347-fanlvxqs	356	4	al	al	NNP
cord-296347-fanlvxqs	356	5	.	.	NNP
cord-296347-fanlvxqs	356	6	,	,	,
cord-296347-fanlvxqs	356	7	2005	2005	CD
cord-296347-fanlvxqs	356	8	)	)	-RRB-
cord-296347-fanlvxqs	356	9	and	and	CC
cord-296347-fanlvxqs	356	10	ER	ER	NNP
cord-296347-fanlvxqs	356	11	stress	stress	NN
cord-296347-fanlvxqs	356	12	-	-	HYPH
cord-296347-fanlvxqs	356	13	induced	induce	VBN
cord-296347-fanlvxqs	356	14	association	association	NN
cord-296347-fanlvxqs	356	15	with	with	IN
cord-296347-fanlvxqs	356	16	C	C	NNP
cord-296347-fanlvxqs	356	17	-	-	HYPH
cord-296347-fanlvxqs	356	18	terminus	terminus	NN
cord-296347-fanlvxqs	356	19	of	of	IN
cord-296347-fanlvxqs	356	20	Hsc70-interacting	hsc70-interacte	VBG
cord-296347-fanlvxqs	356	21	protein	protein	NN
cord-296347-fanlvxqs	356	22	(	(	-LRB-
cord-296347-fanlvxqs	356	23	CHIP	CHIP	NNP
cord-296347-fanlvxqs	356	24	)	)	-RRB-
cord-296347-fanlvxqs	356	25	,	,	.
cord-296347-fanlvxqs	357	1	involved	involve	VBN
cord-296347-fanlvxqs	357	2	in	in	IN
cord-296347-fanlvxqs	357	3	cytosolic	cytosolic	JJ
cord-296347-fanlvxqs	357	4	chaperone	chaperone	NN
cord-296347-fanlvxqs	357	5	-	-	HYPH
cord-296347-fanlvxqs	357	6	dependent	dependent	JJ
cord-296347-fanlvxqs	357	7	folding	folding	NN
cord-296347-fanlvxqs	357	8	,	,	,
cord-296347-fanlvxqs	357	9	regulate	regulate	VB
cord-296347-fanlvxqs	357	10	Parkin	Parkin	NNP
cord-296347-fanlvxqs	357	11	E3	E3	NNP
cord-296347-fanlvxqs	357	12	ligase	ligase	NN
cord-296347-fanlvxqs	357	13	activity	activity	NN
cord-296347-fanlvxqs	357	14	(	(	-LRB-
cord-296347-fanlvxqs	357	15	Imai	Imai	NNP
cord-296347-fanlvxqs	357	16	et	et	NNP
cord-296347-fanlvxqs	357	17	al	al	NNP
cord-296347-fanlvxqs	357	18	.	.	.
cord-296347-fanlvxqs	358	1	,	,	,
cord-296347-fanlvxqs	358	2	2002	2002	CD
cord-296347-fanlvxqs	358	3	;	;	:
cord-296347-fanlvxqs	358	4	Sahara	Sahara	NNP
cord-296347-fanlvxqs	358	5	et	et	FW
cord-296347-fanlvxqs	358	6	al	al	NNP
cord-296347-fanlvxqs	358	7	.	.	NNP
cord-296347-fanlvxqs	358	8	,	,	,
cord-296347-fanlvxqs	358	9	2005	2005	CD
cord-296347-fanlvxqs	358	10	)	)	-RRB-
cord-296347-fanlvxqs	358	11	,	,	,
cord-296347-fanlvxqs	358	12	which	which	WDT
cord-296347-fanlvxqs	358	13	could	could	MD
cord-296347-fanlvxqs	358	14	be	be	VB
cord-296347-fanlvxqs	358	15	beneficial	beneficial	JJ
cord-296347-fanlvxqs	358	16	for	for	IN
cord-296347-fanlvxqs	358	17	reduction	reduction	NN
cord-296347-fanlvxqs	358	18	of	of	IN
cord-296347-fanlvxqs	358	19	protein	protein	NN
cord-296347-fanlvxqs	358	20	aggregates	aggregate	NNS
cord-296347-fanlvxqs	358	21	and	and	CC
cord-296347-fanlvxqs	358	22	cellular	cellular	JJ
cord-296347-fanlvxqs	358	23	pathology	pathology	NN
cord-296347-fanlvxqs	358	24	.	.	.
cord-296347-fanlvxqs	359	1	How	how	WRB
cord-296347-fanlvxqs	359	2	specificity	specificity	NN
cord-296347-fanlvxqs	359	3	in	in	IN
cord-296347-fanlvxqs	359	4	substrate	substrate	NN
cord-296347-fanlvxqs	359	5	selection	selection	NN
cord-296347-fanlvxqs	359	6	is	be	VBZ
cord-296347-fanlvxqs	359	7	conferred	confer	VBN
cord-296347-fanlvxqs	359	8	can	can	MD
cord-296347-fanlvxqs	359	9	be	be	VB
cord-296347-fanlvxqs	359	10	illustrated	illustrate	VBN
cord-296347-fanlvxqs	359	11	by	by	IN
cord-296347-fanlvxqs	359	12	E3s	e3s	NN
cord-296347-fanlvxqs	359	13	involved	involve	VBN
cord-296347-fanlvxqs	359	14	in	in	IN
cord-296347-fanlvxqs	359	15	glycoprotein	glycoprotein	NN
cord-296347-fanlvxqs	359	16	turnover	turnover	NN
cord-296347-fanlvxqs	359	17	.	.	.
cord-296347-fanlvxqs	360	1	The	the	DT
cord-296347-fanlvxqs	360	2	F	F	NNP
cord-296347-fanlvxqs	360	3	-	-	HYPH
cord-296347-fanlvxqs	360	4	box	box	NN
cord-296347-fanlvxqs	360	5	proteins	protein	NNS
cord-296347-fanlvxqs	361	1	Fbs1	Fbs1	NNP
cord-296347-fanlvxqs	361	2	and	and	CC
cord-296347-fanlvxqs	361	3	Fbs2	Fbs2	NNP
cord-296347-fanlvxqs	361	4	bind	bind	VBP
cord-296347-fanlvxqs	361	5	high	high	JJ
cord-296347-fanlvxqs	361	6	mannose	mannose	NN
cord-296347-fanlvxqs	361	7	N	n	NN
cord-296347-fanlvxqs	361	8	-	-	HYPH
cord-296347-fanlvxqs	361	9	linked	link	VBN
cord-296347-fanlvxqs	361	10	glycoproteins	glycoprotein	NNS
cord-296347-fanlvxqs	361	11	(	(	-LRB-
cord-296347-fanlvxqs	361	12	Winston	Winston	NNP
cord-296347-fanlvxqs	361	13	et	et	NNP
cord-296347-fanlvxqs	361	14	al	al	NNP
cord-296347-fanlvxqs	361	15	.	.	NNP
cord-296347-fanlvxqs	361	16	,	,	,
cord-296347-fanlvxqs	361	17	1999	1999	CD
cord-296347-fanlvxqs	361	18	)	)	-RRB-
cord-296347-fanlvxqs	361	19	.	.	.
cord-296347-fanlvxqs	362	1	By	by	IN
cord-296347-fanlvxqs	362	2	using	use	VBG
cord-296347-fanlvxqs	362	3	Fbs1/	Fbs1/	NNP
cord-296347-fanlvxqs	362	4	Fbs2	Fbs2	NNP
cord-296347-fanlvxqs	362	5	as	as	IN
cord-296347-fanlvxqs	362	6	its	-PRON-	PRP$
cord-296347-fanlvxqs	362	7	substrate	substrate	NN
cord-296347-fanlvxqs	362	8	adaptor(s	adaptor(s	NNP
cord-296347-fanlvxqs	362	9	)	)	-RRB-
cord-296347-fanlvxqs	362	10	,	,	,
cord-296347-fanlvxqs	362	11	the	the	DT
cord-296347-fanlvxqs	362	12	cytosolic	cytosolic	JJ
cord-296347-fanlvxqs	362	13	SCF	SCF	NNP
cord-296347-fanlvxqs	362	14	Fbs1,Fbs2	fbs1,fbs2	NN
cord-296347-fanlvxqs	362	15	E3	e3	NN
cord-296347-fanlvxqs	362	16	ligase	ligase	NN
cord-296347-fanlvxqs	362	17	is	be	VBZ
cord-296347-fanlvxqs	362	18	rendered	render	VBN
cord-296347-fanlvxqs	362	19	specific	specific	JJ
cord-296347-fanlvxqs	362	20	for	for	IN
cord-296347-fanlvxqs	362	21	glycoproteins	glycoprotein	NNS
cord-296347-fanlvxqs	362	22	that	that	WDT
cord-296347-fanlvxqs	362	23	have	have	VBP
cord-296347-fanlvxqs	362	24	been	be	VBN
cord-296347-fanlvxqs	362	25	dislocated	dislocate	VBN
cord-296347-fanlvxqs	362	26	from	from	IN
cord-296347-fanlvxqs	362	27	the	the	DT
cord-296347-fanlvxqs	362	28	ER	ER	NNP
cord-296347-fanlvxqs	363	1	(	(	-LRB-
cord-296347-fanlvxqs	363	2	Yoshida	Yoshida	NNP
cord-296347-fanlvxqs	363	3	et	et	NNP
cord-296347-fanlvxqs	363	4	al	al	NNP
cord-296347-fanlvxqs	363	5	.	.	.
cord-296347-fanlvxqs	364	1	,	,	,
cord-296347-fanlvxqs	364	2	2002	2002	CD
cord-296347-fanlvxqs	364	3	(	(	-LRB-
cord-296347-fanlvxqs	364	4	Fig	Fig	NNP
cord-296347-fanlvxqs	364	5	.	.	.
cord-296347-fanlvxqs	364	6	4A	4a	CD
cord-296347-fanlvxqs	364	7	)	)	-RRB-
cord-296347-fanlvxqs	364	8	.	.	.
cord-296347-fanlvxqs	365	1	The	the	DT
cord-296347-fanlvxqs	365	2	CHIP	chip	NN
cord-296347-fanlvxqs	365	3	U	U	NNP
cord-296347-fanlvxqs	365	4	-	-	HYPH
cord-296347-fanlvxqs	365	5	box	box	NN
cord-296347-fanlvxqs	365	6	E3	e3	NN
cord-296347-fanlvxqs	365	7	ligase	ligase	NN
cord-296347-fanlvxqs	365	8	which	which	WDT
cord-296347-fanlvxqs	365	9	is	be	VBZ
cord-296347-fanlvxqs	365	10	involved	involve	VBN
cord-296347-fanlvxqs	365	11	in	in	IN
cord-296347-fanlvxqs	365	12	the	the	DT
cord-296347-fanlvxqs	365	13	degradation	degradation	NN
cord-296347-fanlvxqs	365	14	of	of	IN
cord-296347-fanlvxqs	365	15	CFTR	CFTR	NNP
cord-296347-fanlvxqs	365	16	(	(	-LRB-
cord-296347-fanlvxqs	365	17	Meacham	Meacham	NNP
cord-296347-fanlvxqs	365	18	et	et	NNP
cord-296347-fanlvxqs	365	19	al	al	NNP
cord-296347-fanlvxqs	365	20	.	.	NNP
cord-296347-fanlvxqs	365	21	,	,	,
cord-296347-fanlvxqs	365	22	2001	2001	CD
cord-296347-fanlvxqs	365	23	)	)	-RRB-
cord-296347-fanlvxqs	365	24	and	and	CC
cord-296347-fanlvxqs	365	25	glucocorticoid	glucocorticoid	JJ
cord-296347-fanlvxqs	365	26	hormone	hormone	NN
cord-296347-fanlvxqs	365	27	receptor	receptor	NN
cord-296347-fanlvxqs	365	28	(	(	-LRB-
cord-296347-fanlvxqs	365	29	Meacham	Meacham	NNP
cord-296347-fanlvxqs	365	30	et	et	NNP
cord-296347-fanlvxqs	365	31	al	al	NNP
cord-296347-fanlvxqs	365	32	.	.	NNP
cord-296347-fanlvxqs	365	33	,	,	,
cord-296347-fanlvxqs	365	34	2001	2001	CD
cord-296347-fanlvxqs	365	35	)	)	-RRB-
cord-296347-fanlvxqs	365	36	,	,	,
cord-296347-fanlvxqs	365	37	can	can	MD
cord-296347-fanlvxqs	365	38	be	be	VB
cord-296347-fanlvxqs	365	39	'	'	``
cord-296347-fanlvxqs	365	40	'	'	``
cord-296347-fanlvxqs	365	41	manipulated	manipulate	VBN
cord-296347-fanlvxqs	365	42	'	'	''
cord-296347-fanlvxqs	365	43	'	'	''
cord-296347-fanlvxqs	365	44	to	to	TO
cord-296347-fanlvxqs	365	45	function	function	VB
cord-296347-fanlvxqs	365	46	in	in	IN
cord-296347-fanlvxqs	365	47	ER	ER	NNP
cord-296347-fanlvxqs	365	48	glycoprotein	glycoprotein	NN
cord-296347-fanlvxqs	365	49	turnover	turnover	NN
cord-296347-fanlvxqs	365	50	.	.	.
cord-296347-fanlvxqs	366	1	CHIP	chip	NN
cord-296347-fanlvxqs	366	2	usually	usually	RB
cord-296347-fanlvxqs	366	3	serves	serve	VBZ
cord-296347-fanlvxqs	366	4	as	as	IN
cord-296347-fanlvxqs	366	5	a	a	DT
cord-296347-fanlvxqs	366	6	cochaperone	cochaperone	NN
cord-296347-fanlvxqs	366	7	for	for	IN
cord-296347-fanlvxqs	366	8	the	the	DT
cord-296347-fanlvxqs	366	9	cytosolic	cytosolic	JJ
cord-296347-fanlvxqs	366	10	heat	heat	NN
cord-296347-fanlvxqs	366	11	shock	shock	NN
cord-296347-fanlvxqs	366	12	protein	protein	NN
cord-296347-fanlvxqs	366	13	Hsp70	Hsp70	NNP
cord-296347-fanlvxqs	366	14	/	/	SYM
cord-296347-fanlvxqs	366	15	Hsp90	Hsp90	NNP
cord-296347-fanlvxqs	366	16	chaperone	chaperone	NN
cord-296347-fanlvxqs	366	17	system	system	NN
cord-296347-fanlvxqs	366	18	.	.	.
cord-296347-fanlvxqs	367	1	The	the	DT
cord-296347-fanlvxqs	367	2	CHIP	chip	NN
cord-296347-fanlvxqs	367	3	N	n	NN
cord-296347-fanlvxqs	367	4	-	-	HYPH
cord-296347-fanlvxqs	367	5	terminal	terminal	NN
cord-296347-fanlvxqs	367	6	TPR	TPR	NNP
cord-296347-fanlvxqs	367	7	motif	motif	NN
cord-296347-fanlvxqs	367	8	recruits	recruit	VBZ
cord-296347-fanlvxqs	367	9	Hsp	Hsp	NNP
cord-296347-fanlvxqs	367	10	chaperones	chaperone	NNS
cord-296347-fanlvxqs	367	11	loaded	load	VBN
cord-296347-fanlvxqs	367	12	with	with	IN
cord-296347-fanlvxqs	367	13	misfolded	misfolded	JJ
cord-296347-fanlvxqs	367	14	proteins	protein	NNS
cord-296347-fanlvxqs	367	15	,	,	,
cord-296347-fanlvxqs	367	16	whereas	whereas	IN
cord-296347-fanlvxqs	367	17	its	-PRON-	PRP$
cord-296347-fanlvxqs	367	18	C	c	NN
cord-296347-fanlvxqs	367	19	-	-	HYPH
cord-296347-fanlvxqs	367	20	terminal	terminal	NN
cord-296347-fanlvxqs	367	21	U	U	NNP
cord-296347-fanlvxqs	367	22	-	-	HYPH
cord-296347-fanlvxqs	367	23	box	box	NN
cord-296347-fanlvxqs	367	24	RING	ring	NN
cord-296347-fanlvxqs	367	25	domain	domain	NN
cord-296347-fanlvxqs	367	26	recruits	recruit	VBZ
cord-296347-fanlvxqs	367	27	E2	E2	NNP
cord-296347-fanlvxqs	367	28	enzymes	enzyme	NNS
cord-296347-fanlvxqs	367	29	(	(	-LRB-
cord-296347-fanlvxqs	368	1	Murata	Murata	NNP
cord-296347-fanlvxqs	368	2	et	et	NNP
cord-296347-fanlvxqs	368	3	al	al	NNP
cord-296347-fanlvxqs	368	4	.	.	.
cord-296347-fanlvxqs	369	1	,	,	,
cord-296347-fanlvxqs	369	2	2003	2003	CD
cord-296347-fanlvxqs	369	3	)	)	-RRB-
cord-296347-fanlvxqs	369	4	(	(	-LRB-
cord-296347-fanlvxqs	369	5	Fig	Fig	NNP
cord-296347-fanlvxqs	369	6	.	.	.
cord-296347-fanlvxqs	369	7	4B	4B	NNP
cord-296347-fanlvxqs	369	8	)	)	-RRB-
cord-296347-fanlvxqs	369	9	,	,	,
cord-296347-fanlvxqs	369	10	effectively	effectively	RB
cord-296347-fanlvxqs	369	11	linking	link	VBG
cord-296347-fanlvxqs	369	12	protein	protein	NN
cord-296347-fanlvxqs	369	13	folding	fold	VBG
cord-296347-fanlvxqs	369	14	with	with	IN
cord-296347-fanlvxqs	369	15	ubiquitination	ubiquitination	NN
cord-296347-fanlvxqs	369	16	.	.	.
cord-296347-fanlvxqs	370	1	The	the	DT
cord-296347-fanlvxqs	370	2	CHIP	chip	NN
cord-296347-fanlvxqs	370	3	E3	e3	NN
cord-296347-fanlvxqs	370	4	ligase	ligase	NN
cord-296347-fanlvxqs	370	5	activity	activity	NN
cord-296347-fanlvxqs	370	6	can	can	MD
cord-296347-fanlvxqs	370	7	be	be	VB
cord-296347-fanlvxqs	370	8	directed	direct	VBN
cord-296347-fanlvxqs	370	9	to	to	IN
cord-296347-fanlvxqs	370	10	ER	ER	NNP
cord-296347-fanlvxqs	370	11	glycoprotein	glycoprotein	NN
cord-296347-fanlvxqs	370	12	turnover	turnover	NN
cord-296347-fanlvxqs	370	13	by	by	IN
cord-296347-fanlvxqs	370	14	binding	bind	VBG
cord-296347-fanlvxqs	370	15	to	to	IN
cord-296347-fanlvxqs	370	16	Fbs2	Fbs2	NNP
cord-296347-fanlvxqs	370	17	(	(	-LRB-
cord-296347-fanlvxqs	370	18	Nelson	Nelson	NNP
cord-296347-fanlvxqs	370	19	et	et	NNP
cord-296347-fanlvxqs	370	20	al	al	NNP
cord-296347-fanlvxqs	370	21	.	.	NNP
cord-296347-fanlvxqs	370	22	,	,	,
cord-296347-fanlvxqs	370	23	2006	2006	CD
cord-296347-fanlvxqs	370	24	)	)	-RRB-
cord-296347-fanlvxqs	370	25	,	,	,
cord-296347-fanlvxqs	370	26	through	through	IN
cord-296347-fanlvxqs	370	27	an	an	DT
cord-296347-fanlvxqs	370	28	interaction	interaction	NN
cord-296347-fanlvxqs	370	29	between	between	IN
cord-296347-fanlvxqs	370	30	its	-PRON-	PRP$
cord-296347-fanlvxqs	370	31	TPR	TPR	NNP
cord-296347-fanlvxqs	370	32	motif	motif	NN
cord-296347-fanlvxqs	370	33	and	and	CC
cord-296347-fanlvxqs	370	34	a	a	DT
cord-296347-fanlvxqs	370	35	PEST	pest	NN
cord-296347-fanlvxqs	370	36	motif	motif	NN
cord-296347-fanlvxqs	370	37	in	in	IN
cord-296347-fanlvxqs	370	38	Fbs2	Fbs2	NNP
cord-296347-fanlvxqs	370	39	(	(	-LRB-
cord-296347-fanlvxqs	370	40	Fig	Fig	NNP
cord-296347-fanlvxqs	370	41	.	.	.
cord-296347-fanlvxqs	370	42	4C	4c	CD
cord-296347-fanlvxqs	370	43	)	)	-RRB-
cord-296347-fanlvxqs	370	44	.	.	.
cord-296347-fanlvxqs	371	1	N	n	CD
cord-296347-fanlvxqs	371	2	-	-	HYPH
cord-296347-fanlvxqs	371	3	linked	link	VBN
cord-296347-fanlvxqs	371	4	glycans	glycan	NNS
cord-296347-fanlvxqs	371	5	can	can	MD
cord-296347-fanlvxqs	371	6	,	,	,
cord-296347-fanlvxqs	371	7	therefore	therefore	RB
cord-296347-fanlvxqs	371	8	,	,	,
cord-296347-fanlvxqs	371	9	function	function	VB
cord-296347-fanlvxqs	371	10	in	in	IN
cord-296347-fanlvxqs	371	11	ER	ER	NNP
cord-296347-fanlvxqs	371	12	quality	quality	NN
cord-296347-fanlvxqs	371	13	control	control	NN
cord-296347-fanlvxqs	371	14	not	not	RB
cord-296347-fanlvxqs	371	15	only	only	RB
cord-296347-fanlvxqs	371	16	to	to	TO
cord-296347-fanlvxqs	371	17	regulate	regulate	VB
cord-296347-fanlvxqs	371	18	ER	ER	NNP
cord-296347-fanlvxqs	371	19	retention	retention	NN
cord-296347-fanlvxqs	371	20	in	in	IN
cord-296347-fanlvxqs	371	21	the	the	DT
cord-296347-fanlvxqs	371	22	folding	folding	NN
cord-296347-fanlvxqs	371	23	cycle	cycle	NN
cord-296347-fanlvxqs	371	24	,	,	,
cord-296347-fanlvxqs	371	25	but	but	CC
cord-296347-fanlvxqs	371	26	also	also	RB
cord-296347-fanlvxqs	371	27	to	to	TO
cord-296347-fanlvxqs	371	28	function	function	VB
cord-296347-fanlvxqs	371	29	in	in	IN
cord-296347-fanlvxqs	371	30	ERAD	ERAD	NNP
cord-296347-fanlvxqs	371	31	substrate	substrate	NN
cord-296347-fanlvxqs	371	32	selection	selection	NN
cord-296347-fanlvxqs	371	33	and	and	CC
cord-296347-fanlvxqs	371	34	ubiquitination	ubiquitination	NN
cord-296347-fanlvxqs	371	35	,	,	,
cord-296347-fanlvxqs	371	36	adding	add	VBG
cord-296347-fanlvxqs	371	37	an	an	DT
cord-296347-fanlvxqs	371	38	additional	additional	JJ
cord-296347-fanlvxqs	371	39	layer	layer	NN
cord-296347-fanlvxqs	371	40	of	of	IN
cord-296347-fanlvxqs	371	41	complexity	complexity	NN
cord-296347-fanlvxqs	371	42	and	and	CC
cord-296347-fanlvxqs	371	43	specificity	specificity	NN
cord-296347-fanlvxqs	371	44	to	to	IN
cord-296347-fanlvxqs	371	45	glycoprotein	glycoprotein	NN
cord-296347-fanlvxqs	371	46	quality	quality	NN
cord-296347-fanlvxqs	371	47	control	control	NN
cord-296347-fanlvxqs	371	48	(	(	-LRB-
cord-296347-fanlvxqs	371	49	Nelson	Nelson	NNP
cord-296347-fanlvxqs	371	50	et	et	NNP
cord-296347-fanlvxqs	371	51	al	al	NNP
cord-296347-fanlvxqs	371	52	.	.	NNP
cord-296347-fanlvxqs	371	53	,	,	,
cord-296347-fanlvxqs	371	54	2006	2006	CD
cord-296347-fanlvxqs	371	55	;	;	:
cord-296347-fanlvxqs	371	56	Yoshida	Yoshida	NNP
cord-296347-fanlvxqs	371	57	,	,	,
cord-296347-fanlvxqs	371	58	2003	2003	CD
cord-296347-fanlvxqs	371	59	)	)	-RRB-
cord-296347-fanlvxqs	371	60	.	.	.
cord-296347-fanlvxqs	371	61	 	 	_SP
cord-296347-fanlvxqs	372	1	Export	export	NN
cord-296347-fanlvxqs	372	2	of	of	IN
cord-296347-fanlvxqs	372	3	proteins	protein	NNS
cord-296347-fanlvxqs	372	4	through	through	IN
cord-296347-fanlvxqs	372	5	the	the	DT
cord-296347-fanlvxqs	372	6	ER	ER	NNP
cord-296347-fanlvxqs	372	7	membrane	membrane	NN
cord-296347-fanlvxqs	372	8	most	most	RBS
cord-296347-fanlvxqs	372	9	likely	likely	RB
cord-296347-fanlvxqs	372	10	takes	take	VBZ
cord-296347-fanlvxqs	372	11	place	place	NN
cord-296347-fanlvxqs	372	12	via	via	IN
cord-296347-fanlvxqs	372	13	an	an	DT
cord-296347-fanlvxqs	372	14	aqueous	aqueous	JJ
cord-296347-fanlvxqs	372	15	channel	channel	NN
cord-296347-fanlvxqs	372	16	that	that	WDT
cord-296347-fanlvxqs	372	17	allows	allow	VBZ
cord-296347-fanlvxqs	372	18	the	the	DT
cord-296347-fanlvxqs	372	19	passage	passage	NN
cord-296347-fanlvxqs	372	20	of	of	IN
cord-296347-fanlvxqs	372	21	polypeptides	polypeptide	NNS
cord-296347-fanlvxqs	372	22	through	through	IN
cord-296347-fanlvxqs	372	23	the	the	DT
cord-296347-fanlvxqs	372	24	highly	highly	RB
cord-296347-fanlvxqs	372	25	hydrophobic	hydrophobic	JJ
cord-296347-fanlvxqs	372	26	ER	er	NN
cord-296347-fanlvxqs	372	27	membrane	membrane	NN
cord-296347-fanlvxqs	372	28	environment	environment	NN
cord-296347-fanlvxqs	372	29	while	while	IN
cord-296347-fanlvxqs	372	30	maintaining	maintain	VBG
cord-296347-fanlvxqs	372	31	proper	proper	JJ
cord-296347-fanlvxqs	372	32	ionic	ionic	JJ
cord-296347-fanlvxqs	372	33	balance	balance	NN
cord-296347-fanlvxqs	372	34	between	between	IN
cord-296347-fanlvxqs	372	35	the	the	DT
cord-296347-fanlvxqs	372	36	ER	ER	NNP
cord-296347-fanlvxqs	372	37	and	and	CC
cord-296347-fanlvxqs	372	38	the	the	DT
cord-296347-fanlvxqs	372	39	cytoplasm	cytoplasm	NN
cord-296347-fanlvxqs	372	40	.	.	.
cord-296347-fanlvxqs	373	1	The	the	DT
cord-296347-fanlvxqs	373	2	Sec61	Sec61	NNP
cord-296347-fanlvxqs	373	3	channel	channel	NN
cord-296347-fanlvxqs	373	4	,	,	,
cord-296347-fanlvxqs	373	5	the	the	DT
cord-296347-fanlvxqs	373	6	very	very	RB
cord-296347-fanlvxqs	373	7	same	same	JJ
cord-296347-fanlvxqs	373	8	channel	channel	NN
cord-296347-fanlvxqs	373	9	responsible	responsible	JJ
cord-296347-fanlvxqs	373	10	for	for	IN
cord-296347-fanlvxqs	373	11	protein	protein	NN
cord-296347-fanlvxqs	373	12	import	import	NN
cord-296347-fanlvxqs	373	13	into	into	IN
cord-296347-fanlvxqs	373	14	the	the	DT
cord-296347-fanlvxqs	373	15	ER	ER	NNP
cord-296347-fanlvxqs	373	16	,	,	,
cord-296347-fanlvxqs	373	17	was	be	VBD
cord-296347-fanlvxqs	373	18	initially	initially	RB
cord-296347-fanlvxqs	373	19	thought	think	VBN
cord-296347-fanlvxqs	373	20	to	to	TO
cord-296347-fanlvxqs	373	21	mediate	mediate	VB
cord-296347-fanlvxqs	373	22	transport	transport	NN
cord-296347-fanlvxqs	373	23	in	in	IN
cord-296347-fanlvxqs	373	24	the	the	DT
cord-296347-fanlvxqs	373	25	reverse	reverse	JJ
cord-296347-fanlvxqs	373	26	direction	direction	NN
cord-296347-fanlvxqs	373	27	(	(	-LRB-
cord-296347-fanlvxqs	373	28	hence	hence	RB
cord-296347-fanlvxqs	373	29	the	the	DT
cord-296347-fanlvxqs	373	30	name	name	NN
cord-296347-fanlvxqs	373	31	retrograde	retrograde	JJ
cord-296347-fanlvxqs	373	32	translocation	translocation	NN
cord-296347-fanlvxqs	373	33	or	or	CC
cord-296347-fanlvxqs	373	34	retrotranslocation	retrotranslocation	NN
cord-296347-fanlvxqs	373	35	also	also	RB
cord-296347-fanlvxqs	373	36	coined	coin	VBD
cord-296347-fanlvxqs	373	37	for	for	IN
cord-296347-fanlvxqs	373	38	the	the	DT
cord-296347-fanlvxqs	373	39	dislocation	dislocation	NN
cord-296347-fanlvxqs	373	40	process	process	NN
cord-296347-fanlvxqs	373	41	)	)	-RRB-
cord-296347-fanlvxqs	374	1	(	(	-LRB-
cord-296347-fanlvxqs	374	2	Pilon	Pilon	NNP
cord-296347-fanlvxqs	374	3	et	et	NNP
cord-296347-fanlvxqs	374	4	al	al	NNP
cord-296347-fanlvxqs	374	5	.	.	NNP
cord-296347-fanlvxqs	374	6	,	,	,
cord-296347-fanlvxqs	374	7	1997	1997	CD
cord-296347-fanlvxqs	375	1	;	;	:
cord-296347-fanlvxqs	375	2	Plemper	Plemper	NNP
cord-296347-fanlvxqs	375	3	et	et	NNP
cord-296347-fanlvxqs	375	4	al	al	NNP
cord-296347-fanlvxqs	375	5	.	.	NNP
cord-296347-fanlvxqs	375	6	,	,	,
cord-296347-fanlvxqs	375	7	1997	1997	CD
cord-296347-fanlvxqs	376	1	Plemper	Plemper	NNP
cord-296347-fanlvxqs	376	2	et	et	NNP
cord-296347-fanlvxqs	376	3	al	al	NNP
cord-296347-fanlvxqs	376	4	.	.	NNP
cord-296347-fanlvxqs	376	5	,	,	,
cord-296347-fanlvxqs	376	6	,	,	,
cord-296347-fanlvxqs	376	7	1998	1998	CD
cord-296347-fanlvxqs	377	1	Wiertz	Wiertz	NNP
cord-296347-fanlvxqs	377	2	et	et	NNP
cord-296347-fanlvxqs	377	3	al	al	NNP
cord-296347-fanlvxqs	377	4	.	.	NNP
cord-296347-fanlvxqs	377	5	,	,	,
cord-296347-fanlvxqs	377	6	1996b	1996b	CD
cord-296347-fanlvxqs	377	7	)	)	-RRB-
cord-296347-fanlvxqs	377	8	,	,	,
cord-296347-fanlvxqs	377	9	with	with	IN
cord-296347-fanlvxqs	377	10	accessory	accessory	JJ
cord-296347-fanlvxqs	377	11	factors	factor	NNS
cord-296347-fanlvxqs	377	12	regulating	regulate	VBG
cord-296347-fanlvxqs	377	13	directionality	directionality	NN
cord-296347-fanlvxqs	377	14	and	and	CC
cord-296347-fanlvxqs	377	15	specificity	specificity	NN
cord-296347-fanlvxqs	377	16	of	of	IN
cord-296347-fanlvxqs	377	17	the	the	DT
cord-296347-fanlvxqs	377	18	channel	channel	NN
cord-296347-fanlvxqs	377	19	.	.	.
cord-296347-fanlvxqs	378	1	The	the	DT
cord-296347-fanlvxqs	378	2	extent	extent	NN
cord-296347-fanlvxqs	378	3	to	to	IN
cord-296347-fanlvxqs	378	4	which	which	WDT
cord-296347-fanlvxqs	379	1	Sec61	Sec61	NNP
cord-296347-fanlvxqs	379	2	is	be	VBZ
cord-296347-fanlvxqs	379	3	involved	involve	VBN
cord-296347-fanlvxqs	379	4	in	in	IN
cord-296347-fanlvxqs	379	5	ER	ER	NNP
cord-296347-fanlvxqs	379	6	dislocation	dislocation	NN
cord-296347-fanlvxqs	379	7	or	or	CC
cord-296347-fanlvxqs	379	8	the	the	DT
cord-296347-fanlvxqs	379	9	identity	identity	NN
cord-296347-fanlvxqs	379	10	of	of	IN
cord-296347-fanlvxqs	379	11	the	the	DT
cord-296347-fanlvxqs	379	12	'	'	``
cord-296347-fanlvxqs	379	13	'	'	``
cord-296347-fanlvxqs	379	14	dislocon	dislocon	NN
cord-296347-fanlvxqs	379	15	'	'	''
cord-296347-fanlvxqs	379	16	'	'	''
cord-296347-fanlvxqs	379	17	are	be	VBP
cord-296347-fanlvxqs	379	18	not	not	RB
cord-296347-fanlvxqs	379	19	without	without	IN
cord-296347-fanlvxqs	379	20	controversy	controversy	NN
cord-296347-fanlvxqs	379	21	,	,	,
cord-296347-fanlvxqs	379	22	and	and	CC
cord-296347-fanlvxqs	379	23	the	the	DT
cord-296347-fanlvxqs	379	24	search	search	NN
cord-296347-fanlvxqs	379	25	for	for	IN
cord-296347-fanlvxqs	379	26	a	a	DT
cord-296347-fanlvxqs	379	27	dislocation	dislocation	NN
cord-296347-fanlvxqs	379	28	channel(s	channel(s	NNP
cord-296347-fanlvxqs	379	29	)	)	-RRB-
cord-296347-fanlvxqs	379	30	is	be	VBZ
cord-296347-fanlvxqs	379	31	a	a	DT
cord-296347-fanlvxqs	379	32	subject	subject	NN
cord-296347-fanlvxqs	379	33	of	of	IN
cord-296347-fanlvxqs	379	34	intense	intense	JJ
cord-296347-fanlvxqs	379	35	research	research	NN
cord-296347-fanlvxqs	380	1	(	(	-LRB-
cord-296347-fanlvxqs	380	2	Meusser	Meusser	NNP
cord-296347-fanlvxqs	380	3	et	et	NNP
cord-296347-fanlvxqs	380	4	al	al	NNP
cord-296347-fanlvxqs	380	5	.	.	.
cord-296347-fanlvxqs	381	1	,	,	,
cord-296347-fanlvxqs	381	2	2005	2005	CD
cord-296347-fanlvxqs	381	3	;	;	:
cord-296347-fanlvxqs	381	4	Romisch	Romisch	NNP
cord-296347-fanlvxqs	381	5	,	,	,
cord-296347-fanlvxqs	381	6	2005	2005	CD
cord-296347-fanlvxqs	381	7	)	)	-RRB-
cord-296347-fanlvxqs	381	8	.	.	.
cord-296347-fanlvxqs	382	1	Mammalian	Mammalian	NNP
cord-296347-fanlvxqs	382	2	Derlin-1	Derlin-1	NNP
cord-296347-fanlvxqs	382	3	,	,	,
cord-296347-fanlvxqs	382	4	a	a	DT
cord-296347-fanlvxqs	382	5	member	member	NN
cord-296347-fanlvxqs	382	6	of	of	IN
cord-296347-fanlvxqs	382	7	the	the	DT
cord-296347-fanlvxqs	382	8	Der1p	Der1p	NNP
cord-296347-fanlvxqs	382	9	-	-	HYPH
cord-296347-fanlvxqs	382	10	Like	like	JJ
cord-296347-fanlvxqs	382	11	(	(	-LRB-
cord-296347-fanlvxqs	382	12	Derlin	Derlin	NNP
cord-296347-fanlvxqs	382	13	)	)	-RRB-
cord-296347-fanlvxqs	382	14	family	family	NN
cord-296347-fanlvxqs	382	15	of	of	IN
cord-296347-fanlvxqs	382	16	yeast	yeast	NN
cord-296347-fanlvxqs	382	17	Der1p	Der1p	NNP
cord-296347-fanlvxqs	382	18	homologues	homologue	NNS
cord-296347-fanlvxqs	382	19	,	,	,
cord-296347-fanlvxqs	382	20	is	be	VBZ
cord-296347-fanlvxqs	382	21	involved	involve	VBN
cord-296347-fanlvxqs	382	22	in	in	IN
cord-296347-fanlvxqs	382	23	dislocation	dislocation	NN
cord-296347-fanlvxqs	382	24	from	from	IN
cord-296347-fanlvxqs	382	25	the	the	DT
cord-296347-fanlvxqs	382	26	ER	ER	NNP
cord-296347-fanlvxqs	382	27	(	(	-LRB-
cord-296347-fanlvxqs	382	28	Lilley	Lilley	NNP
cord-296347-fanlvxqs	382	29	and	and	CC
cord-296347-fanlvxqs	382	30	Ploegh	Ploegh	NNP
cord-296347-fanlvxqs	382	31	,	,	,
cord-296347-fanlvxqs	382	32	2004	2004	CD
cord-296347-fanlvxqs	382	33	;	;	:
cord-296347-fanlvxqs	382	34	Ye	Ye	NNP
cord-296347-fanlvxqs	382	35	et	et	NNP
cord-296347-fanlvxqs	382	36	al	al	NNP
cord-296347-fanlvxqs	382	37	.	.	NNP
cord-296347-fanlvxqs	382	38	,	,	,
cord-296347-fanlvxqs	382	39	2004	2004	CD
cord-296347-fanlvxqs	382	40	)	)	-RRB-
cord-296347-fanlvxqs	382	41	and	and	CC
cord-296347-fanlvxqs	382	42	was	be	VBD
cord-296347-fanlvxqs	382	43	proposed	propose	VBN
cord-296347-fanlvxqs	382	44	to	to	TO
cord-296347-fanlvxqs	382	45	constitute	constitute	VB
cord-296347-fanlvxqs	382	46	a	a	DT
cord-296347-fanlvxqs	382	47	channel	channel	NN
cord-296347-fanlvxqs	382	48	for	for	IN
cord-296347-fanlvxqs	382	49	protein	protein	NN
cord-296347-fanlvxqs	382	50	export	export	NN
cord-296347-fanlvxqs	382	51	from	from	IN
cord-296347-fanlvxqs	382	52	the	the	DT
cord-296347-fanlvxqs	382	53	ER	ER	NNP
cord-296347-fanlvxqs	382	54	membrane	membrane	NN
cord-296347-fanlvxqs	382	55	to	to	IN
cord-296347-fanlvxqs	382	56	the	the	DT
cord-296347-fanlvxqs	382	57	cytosol	cytosol	NN
cord-296347-fanlvxqs	382	58	(	(	-LRB-
cord-296347-fanlvxqs	382	59	Lilley	Lilley	NNP
cord-296347-fanlvxqs	382	60	and	and	CC
cord-296347-fanlvxqs	382	61	Ploegh	Ploegh	NNP
cord-296347-fanlvxqs	382	62	,	,	,
cord-296347-fanlvxqs	382	63	2004	2004	CD
cord-296347-fanlvxqs	382	64	;	;	:
cord-296347-fanlvxqs	382	65	Ye	Ye	NNP
cord-296347-fanlvxqs	382	66	et	et	NNP
cord-296347-fanlvxqs	382	67	al	al	NNP
cord-296347-fanlvxqs	382	68	.	.	NNP
cord-296347-fanlvxqs	382	69	,	,	,
cord-296347-fanlvxqs	382	70	2004	2004	CD
cord-296347-fanlvxqs	382	71	)	)	-RRB-
cord-296347-fanlvxqs	382	72	.	.	.
cord-296347-fanlvxqs	383	1	Like	like	IN
cord-296347-fanlvxqs	383	2	their	-PRON-	PRP$
cord-296347-fanlvxqs	383	3	yeast	yeast	NN
cord-296347-fanlvxqs	383	4	homologue	homologue	NN
cord-296347-fanlvxqs	383	5	,	,	,
cord-296347-fanlvxqs	383	6	Derlins	Derlins	NNP
cord-296347-fanlvxqs	383	7	1	1	CD
cord-296347-fanlvxqs	383	8	,	,	,
cord-296347-fanlvxqs	383	9	2	2	CD
cord-296347-fanlvxqs	383	10	,	,	,
cord-296347-fanlvxqs	383	11	and	and	CC
cord-296347-fanlvxqs	383	12	3	3	CD
cord-296347-fanlvxqs	383	13	are	be	VBP
cord-296347-fanlvxqs	383	14	tetraspanning	tetraspanne	VBG
cord-296347-fanlvxqs	383	15	ER	ER	NNP
cord-296347-fanlvxqs	383	16	membrane	membrane	NN
cord-296347-fanlvxqs	383	17	proteins	protein	NNS
cord-296347-fanlvxqs	383	18	that	that	WDT
cord-296347-fanlvxqs	383	19	can	can	MD
cord-296347-fanlvxqs	383	20	homo	homo	VB
cord-296347-fanlvxqs	383	21	-	-	:
cord-296347-fanlvxqs	383	22	and	and	CC
cord-296347-fanlvxqs	383	23	heteroligomerize	heteroligomerize	NNP
cord-296347-fanlvxqs	383	24	and	and	CC
cord-296347-fanlvxqs	383	25	could	could	MD
cord-296347-fanlvxqs	383	26	presumably	presumably	RB
cord-296347-fanlvxqs	383	27	form	form	VB
cord-296347-fanlvxqs	383	28	higher	high	JJR
cord-296347-fanlvxqs	383	29	order	order	NN
cord-296347-fanlvxqs	383	30	structures	structure	NNS
cord-296347-fanlvxqs	383	31	with	with	IN
cord-296347-fanlvxqs	383	32	channel	channel	NN
cord-296347-fanlvxqs	383	33	-	-	HYPH
cord-296347-fanlvxqs	383	34	like	like	JJ
cord-296347-fanlvxqs	383	35	properties	property	NNS
cord-296347-fanlvxqs	383	36	(	(	-LRB-
cord-296347-fanlvxqs	383	37	Lilley	Lilley	NNP
cord-296347-fanlvxqs	383	38	and	and	CC
cord-296347-fanlvxqs	383	39	Ploegh	Ploegh	NNP
cord-296347-fanlvxqs	383	40	,	,	,
cord-296347-fanlvxqs	383	41	2004	2004	CD
cord-296347-fanlvxqs	383	42	;	;	:
cord-296347-fanlvxqs	383	43	Ye	Ye	NNP
cord-296347-fanlvxqs	383	44	et	et	NNP
cord-296347-fanlvxqs	383	45	al	al	NNP
cord-296347-fanlvxqs	383	46	.	.	NNP
cord-296347-fanlvxqs	383	47	,	,	,
cord-296347-fanlvxqs	383	48	2004	2004	CD
cord-296347-fanlvxqs	383	49	)	)	-RRB-
cord-296347-fanlvxqs	383	50	.	.	.
cord-296347-fanlvxqs	384	1	Conclusive	conclusive	JJ
cord-296347-fanlvxqs	384	2	evidence	evidence	NN
cord-296347-fanlvxqs	384	3	for	for	IN
cord-296347-fanlvxqs	384	4	a	a	DT
cord-296347-fanlvxqs	384	5	role	role	NN
cord-296347-fanlvxqs	384	6	of	of	IN
cord-296347-fanlvxqs	384	7	Derlin-1	Derlin-1	NNP
cord-296347-fanlvxqs	384	8	as	as	IN
cord-296347-fanlvxqs	384	9	a	a	DT
cord-296347-fanlvxqs	384	10	channel	channel	NN
cord-296347-fanlvxqs	384	11	is	be	VBZ
cord-296347-fanlvxqs	384	12	still	still	RB
cord-296347-fanlvxqs	384	13	unavailable	unavailable	JJ
cord-296347-fanlvxqs	384	14	,	,	,
cord-296347-fanlvxqs	384	15	and	and	CC
cord-296347-fanlvxqs	384	16	in	in	IN
cord-296347-fanlvxqs	384	17	any	any	DT
cord-296347-fanlvxqs	384	18	case	case	NN
cord-296347-fanlvxqs	384	19	,	,	,
cord-296347-fanlvxqs	384	20	Derlin-1	Derlin-1	NNP
cord-296347-fanlvxqs	384	21	is	be	VBZ
cord-296347-fanlvxqs	384	22	unlikely	unlikely	JJ
cord-296347-fanlvxqs	384	23	to	to	TO
cord-296347-fanlvxqs	384	24	be	be	VB
cord-296347-fanlvxqs	384	25	the	the	DT
cord-296347-fanlvxqs	384	26	only	only	JJ
cord-296347-fanlvxqs	384	27	channel	channel	NN
cord-296347-fanlvxqs	384	28	,	,	,
cord-296347-fanlvxqs	384	29	as	as	IN
cord-296347-fanlvxqs	384	30	turnover	turnover	NN
cord-296347-fanlvxqs	384	31	of	of	IN
cord-296347-fanlvxqs	384	32	some	some	DT
cord-296347-fanlvxqs	384	33	ERAD	ERAD	NNP
cord-296347-fanlvxqs	384	34	substrates	substrate	NNS
cord-296347-fanlvxqs	384	35	does	do	VBZ
cord-296347-fanlvxqs	384	36	not	not	RB
cord-296347-fanlvxqs	384	37	rely	rely	VB
cord-296347-fanlvxqs	384	38	on	on	IN
cord-296347-fanlvxqs	384	39	Derlin-1	Derlin-1	NNP
cord-296347-fanlvxqs	384	40	function	function	VB
cord-296347-fanlvxqs	384	41	Lilley	Lilley	NNP
cord-296347-fanlvxqs	384	42	and	and	CC
cord-296347-fanlvxqs	384	43	Ploegh	Ploegh	NNP
cord-296347-fanlvxqs	384	44	,	,	,
cord-296347-fanlvxqs	384	45	2004	2004	CD
cord-296347-fanlvxqs	384	46	)	)	-RRB-
cord-296347-fanlvxqs	384	47	.	.	.
cord-296347-fanlvxqs	385	1	Derlins	Derlins	NNP
cord-296347-fanlvxqs	385	2	2	2	CD
cord-296347-fanlvxqs	385	3	and	and	CC
cord-296347-fanlvxqs	385	4	3	3	CD
cord-296347-fanlvxqs	385	5	are	be	VBP
cord-296347-fanlvxqs	385	6	obvious	obvious	JJ
cord-296347-fanlvxqs	385	7	candidates	candidate	NNS
cord-296347-fanlvxqs	385	8	that	that	WDT
cord-296347-fanlvxqs	385	9	could	could	MD
cord-296347-fanlvxqs	385	10	function	function	VB
cord-296347-fanlvxqs	385	11	in	in	IN
cord-296347-fanlvxqs	385	12	place	place	NN
cord-296347-fanlvxqs	385	13	of	of	IN
cord-296347-fanlvxqs	385	14	Derlin-1	Derlin-1	NNP
cord-296347-fanlvxqs	385	15	.	.	.
cord-296347-fanlvxqs	386	1	Alternatively	alternatively	RB
cord-296347-fanlvxqs	386	2	,	,	,
cord-296347-fanlvxqs	386	3	Derlins	Derlins	NNP
cord-296347-fanlvxqs	386	4	may	may	MD
cord-296347-fanlvxqs	386	5	act	act	VB
cord-296347-fanlvxqs	386	6	to	to	TO
cord-296347-fanlvxqs	386	7	deliver	deliver	VB
cord-296347-fanlvxqs	386	8	a	a	DT
cord-296347-fanlvxqs	386	9	particular	particular	JJ
cord-296347-fanlvxqs	386	10	substrate	substrate	NN
cord-296347-fanlvxqs	386	11	to	to	IN
cord-296347-fanlvxqs	386	12	a	a	DT
cord-296347-fanlvxqs	386	13	channel	channel	NN
cord-296347-fanlvxqs	386	14	/	/	,
cord-296347-fanlvxqs	386	15	another	another	DT
cord-296347-fanlvxqs	386	16	adaptor	adaptor	NN
cord-296347-fanlvxqs	386	17	in	in	IN
cord-296347-fanlvxqs	386	18	its	-PRON-	PRP$
cord-296347-fanlvxqs	386	19	cognate	cognate	JJ
cord-296347-fanlvxqs	386	20	dislocation	dislocation	NN
cord-296347-fanlvxqs	386	21	pathway	pathway	NN
cord-296347-fanlvxqs	386	22	.	.	.
cord-296347-fanlvxqs	387	1	In	in	IN
cord-296347-fanlvxqs	387	2	fact	fact	NN
cord-296347-fanlvxqs	387	3	,	,	,
cord-296347-fanlvxqs	387	4	Derlins	Derlins	NNP
cord-296347-fanlvxqs	387	5	form	form	VBP
cord-296347-fanlvxqs	387	6	a	a	DT
cord-296347-fanlvxqs	387	7	large	large	JJ
cord-296347-fanlvxqs	387	8	,	,	,
cord-296347-fanlvxqs	387	9	multiprotein	multiprotein	NN
cord-296347-fanlvxqs	387	10	complex	complex	JJ
cord-296347-fanlvxqs	387	11	with	with	IN
cord-296347-fanlvxqs	387	12	p97	p97	CD
cord-296347-fanlvxqs	387	13	and	and	CC
cord-296347-fanlvxqs	387	14	the	the	DT
cord-296347-fanlvxqs	387	15	Hrd1p	hrd1p	NN
cord-296347-fanlvxqs	387	16	and	and	CC
cord-296347-fanlvxqs	387	17	Hrd3p	Hrd3p	NNP
cord-296347-fanlvxqs	387	18	mammalian	mammalian	JJ
cord-296347-fanlvxqs	387	19	homologues	homologue	NNS
cord-296347-fanlvxqs	387	20	HRD1	HRD1	NNPS
cord-296347-fanlvxqs	387	21	and	and	CC
cord-296347-fanlvxqs	387	22	SEL1L	sel1l	JJ
cord-296347-fanlvxqs	387	23	,	,	,
cord-296347-fanlvxqs	387	24	respectively	respectively	RB
cord-296347-fanlvxqs	387	25	(	(	-LRB-
cord-296347-fanlvxqs	387	26	Lilley	Lilley	NNP
cord-296347-fanlvxqs	387	27	and	and	CC
cord-296347-fanlvxqs	387	28	Ploegh	Ploegh	NNP
cord-296347-fanlvxqs	387	29	,	,	,
cord-296347-fanlvxqs	387	30	2005a	2005a	CD
cord-296347-fanlvxqs	387	31	;	;	:
cord-296347-fanlvxqs	387	32	Ye	Ye	NNP
cord-296347-fanlvxqs	387	33	et	et	NNP
cord-296347-fanlvxqs	387	34	al	al	NNP
cord-296347-fanlvxqs	387	35	.	.	NNP
cord-296347-fanlvxqs	387	36	,	,	,
cord-296347-fanlvxqs	387	37	2005	2005	CD
cord-296347-fanlvxqs	387	38	)	)	-RRB-
cord-296347-fanlvxqs	387	39	,	,	,
cord-296347-fanlvxqs	387	40	suggesting	suggest	VBG
cord-296347-fanlvxqs	387	41	a	a	DT
cord-296347-fanlvxqs	387	42	very	very	RB
cord-296347-fanlvxqs	387	43	intimate	intimate	JJ
cord-296347-fanlvxqs	387	44	connection	connection	NN
cord-296347-fanlvxqs	387	45	between	between	IN
cord-296347-fanlvxqs	387	46	substrate	substrate	NN
cord-296347-fanlvxqs	387	47	recognition	recognition	NN
cord-296347-fanlvxqs	387	48	,	,	,
cord-296347-fanlvxqs	387	49	export	export	NN
cord-296347-fanlvxqs	387	50	through	through	IN
cord-296347-fanlvxqs	387	51	the	the	DT
cord-296347-fanlvxqs	387	52	membrane	membrane	NN
cord-296347-fanlvxqs	387	53	,	,	,
cord-296347-fanlvxqs	387	54	ubiquitination	ubiquitination	NN
cord-296347-fanlvxqs	387	55	,	,	,
cord-296347-fanlvxqs	387	56	and	and	CC
cord-296347-fanlvxqs	387	57	extraction	extraction	NN
cord-296347-fanlvxqs	387	58	into	into	IN
cord-296347-fanlvxqs	387	59	the	the	DT
cord-296347-fanlvxqs	387	60	cytoplasm	cytoplasm	NN
cord-296347-fanlvxqs	387	61	.	.	.
cord-296347-fanlvxqs	388	1	The	the	DT
cord-296347-fanlvxqs	388	2	existence	existence	NN
cord-296347-fanlvxqs	388	3	of	of	IN
cord-296347-fanlvxqs	388	4	such	such	PDT
cord-296347-fanlvxqs	388	5	a	a	DT
cord-296347-fanlvxqs	388	6	complex	complex	NN
cord-296347-fanlvxqs	388	7	that	that	WDT
cord-296347-fanlvxqs	388	8	would	would	MD
cord-296347-fanlvxqs	388	9	integrate	integrate	VB
cord-296347-fanlvxqs	388	10	all	all	DT
cord-296347-fanlvxqs	388	11	of	of	IN
cord-296347-fanlvxqs	388	12	these	these	DT
cord-296347-fanlvxqs	388	13	different	different	JJ
cord-296347-fanlvxqs	388	14	functions	function	NNS
cord-296347-fanlvxqs	388	15	,	,	,
cord-296347-fanlvxqs	388	16	including	include	VBG
cord-296347-fanlvxqs	388	17	formation	formation	NN
cord-296347-fanlvxqs	388	18	of	of	IN
cord-296347-fanlvxqs	388	19	a	a	DT
cord-296347-fanlvxqs	388	20	channel	channel	NN
cord-296347-fanlvxqs	388	21	or	or	CC
cord-296347-fanlvxqs	388	22	dislocon	dislocon	NN
cord-296347-fanlvxqs	388	23	,	,	,
cord-296347-fanlvxqs	388	24	would	would	MD
cord-296347-fanlvxqs	388	25	offer	offer	VB
cord-296347-fanlvxqs	388	26	obvious	obvious	JJ
cord-296347-fanlvxqs	388	27	advantages	advantage	NNS
cord-296347-fanlvxqs	388	28	in	in	IN
cord-296347-fanlvxqs	388	29	terms	term	NNS
cord-296347-fanlvxqs	388	30	of	of	IN
cord-296347-fanlvxqs	388	31	control	control	NN
cord-296347-fanlvxqs	388	32	of	of	IN
cord-296347-fanlvxqs	388	33	both	both	DT
cord-296347-fanlvxqs	388	34	specificity	specificity	NN
cord-296347-fanlvxqs	388	35	and	and	CC
cord-296347-fanlvxqs	388	36	directionality	directionality	NN
cord-296347-fanlvxqs	388	37	of	of	IN
cord-296347-fanlvxqs	388	38	the	the	DT
cord-296347-fanlvxqs	388	39	dislocation	dislocation	NN
cord-296347-fanlvxqs	388	40	process	process	NN
cord-296347-fanlvxqs	388	41	.	.	.
cord-296347-fanlvxqs	389	1	We	-PRON-	PRP
cord-296347-fanlvxqs	389	2	shall	shall	MD
cord-296347-fanlvxqs	389	3	return	return	VB
cord-296347-fanlvxqs	389	4	to	to	IN
cord-296347-fanlvxqs	389	5	this	this	DT
cord-296347-fanlvxqs	389	6	substrate	substrate	NN
cord-296347-fanlvxqs	389	7	'	'	''
cord-296347-fanlvxqs	389	8	'	'	``
cord-296347-fanlvxqs	389	9	guidance	guidance	NN
cord-296347-fanlvxqs	389	10	'	'	''
cord-296347-fanlvxqs	389	11	'	'	''
cord-296347-fanlvxqs	389	12	theme	theme	NN
cord-296347-fanlvxqs	389	13	.	.	.
cord-296347-fanlvxqs	390	1	A	a	DT
cord-296347-fanlvxqs	390	2	cytosolic	cytosolic	JJ
cord-296347-fanlvxqs	390	3	complex	complex	NN
cord-296347-fanlvxqs	390	4	containing	contain	VBG
cord-296347-fanlvxqs	390	5	the	the	DT
cord-296347-fanlvxqs	390	6	AAA	AAA	NNP
cord-296347-fanlvxqs	390	7	ATPase	ATPase	NNP
cord-296347-fanlvxqs	390	8	Cdc48p	Cdc48p	NNP
cord-296347-fanlvxqs	390	9	(	(	-LRB-
cord-296347-fanlvxqs	390	10	yeast	yeast	NN
cord-296347-fanlvxqs	390	11	)	)	-RRB-
cord-296347-fanlvxqs	391	1	[	[	-LRB-
cord-296347-fanlvxqs	391	2	valosin	valosin	NN
cord-296347-fanlvxqs	391	3	-	-	HYPH
cord-296347-fanlvxqs	391	4	containing	contain	VBG
cord-296347-fanlvxqs	391	5	protein	protein	NN
cord-296347-fanlvxqs	391	6	(	(	-LRB-
cord-296347-fanlvxqs	391	7	VCP)/p97	vcp)/p97	NN
cord-296347-fanlvxqs	391	8	(	(	-LRB-
cord-296347-fanlvxqs	391	9	in	in	IN
cord-296347-fanlvxqs	391	10	mammals	mammal	NNS
cord-296347-fanlvxqs	391	11	)	)	-RRB-
cord-296347-fanlvxqs	391	12	]	]	-RRB-
cord-296347-fanlvxqs	391	13	and	and	CC
cord-296347-fanlvxqs	391	14	its	-PRON-	PRP$
cord-296347-fanlvxqs	391	15	cofactors	cofactor	NNS
cord-296347-fanlvxqs	391	16	nuclear	nuclear	JJ
cord-296347-fanlvxqs	391	17	protein	protein	NN
cord-296347-fanlvxqs	391	18	localization	localization	NN
cord-296347-fanlvxqs	391	19	4	4	CD
cord-296347-fanlvxqs	391	20	(	(	-LRB-
cord-296347-fanlvxqs	391	21	Npl4p	Npl4p	NNP
cord-296347-fanlvxqs	391	22	)	)	-RRB-
cord-296347-fanlvxqs	391	23	and	and	CC
cord-296347-fanlvxqs	391	24	ubiquitin	ubiquitin	JJ
cord-296347-fanlvxqs	391	25	-	-	HYPH
cord-296347-fanlvxqs	391	26	fusion	fusion	NN
cord-296347-fanlvxqs	391	27	degradation	degradation	NN
cord-296347-fanlvxqs	391	28	1	1	CD
cord-296347-fanlvxqs	391	29	(	(	-LRB-
cord-296347-fanlvxqs	391	30	Ufd1p	ufd1p	NN
cord-296347-fanlvxqs	391	31	)	)	-RRB-
cord-296347-fanlvxqs	391	32	,	,	,
cord-296347-fanlvxqs	391	33	was	be	VBD
cord-296347-fanlvxqs	391	34	recently	recently	RB
cord-296347-fanlvxqs	391	35	shown	show	VBN
cord-296347-fanlvxqs	391	36	to	to	TO
cord-296347-fanlvxqs	391	37	participate	participate	VB
cord-296347-fanlvxqs	391	38	in	in	IN
cord-296347-fanlvxqs	391	39	ER	ER	NNP
cord-296347-fanlvxqs	391	40	degradation	degradation	NN
cord-296347-fanlvxqs	391	41	(	(	-LRB-
cord-296347-fanlvxqs	391	42	Lord	Lord	NNP
cord-296347-fanlvxqs	391	43	et	et	NNP
cord-296347-fanlvxqs	391	44	al	al	NNP
cord-296347-fanlvxqs	391	45	.	.	NNP
cord-296347-fanlvxqs	391	46	,	,	,
cord-296347-fanlvxqs	391	47	2002	2002	CD
cord-296347-fanlvxqs	391	48	;	;	:
cord-296347-fanlvxqs	391	49	Romisch	Romisch	NNP
cord-296347-fanlvxqs	391	50	,	,	,
cord-296347-fanlvxqs	391	51	2005	2005	CD
cord-296347-fanlvxqs	391	52	;	;	:
cord-296347-fanlvxqs	391	53	Ye	Ye	NNP
cord-296347-fanlvxqs	391	54	et	et	NNP
cord-296347-fanlvxqs	391	55	al	al	NNP
cord-296347-fanlvxqs	391	56	.	.	NNP
cord-296347-fanlvxqs	391	57	,	,	,
cord-296347-fanlvxqs	391	58	2001	2001	CD
cord-296347-fanlvxqs	391	59	)	)	-RRB-
cord-296347-fanlvxqs	391	60	.	.	.
cord-296347-fanlvxqs	392	1	Cdc48p	Cdc48p	NNP
cord-296347-fanlvxqs	392	2	/	/	SYM
cord-296347-fanlvxqs	392	3	p97	p97	CD
cord-296347-fanlvxqs	392	4	is	be	VBZ
cord-296347-fanlvxqs	392	5	an	an	DT
cord-296347-fanlvxqs	392	6	essential	essential	JJ
cord-296347-fanlvxqs	392	7	protein	protein	NN
cord-296347-fanlvxqs	392	8	of	of	IN
cord-296347-fanlvxqs	392	9	the	the	DT
cord-296347-fanlvxqs	392	10	AAA	AAA	NNP
cord-296347-fanlvxqs	392	11	ATPase	ATPase	NNP
cord-296347-fanlvxqs	392	12	(	(	-LRB-
cord-296347-fanlvxqs	392	13	ATPases	ATPases	NNP
cord-296347-fanlvxqs	392	14	associated	associate	VBN
cord-296347-fanlvxqs	392	15	with	with	IN
cord-296347-fanlvxqs	392	16	various	various	JJ
cord-296347-fanlvxqs	392	17	cellular	cellular	JJ
cord-296347-fanlvxqs	392	18	activities	activity	NNS
cord-296347-fanlvxqs	392	19	)	)	-RRB-
cord-296347-fanlvxqs	392	20	family	family	NN
cord-296347-fanlvxqs	392	21	,	,	,
cord-296347-fanlvxqs	392	22	conserved	conserve	VBN
cord-296347-fanlvxqs	392	23	from	from	IN
cord-296347-fanlvxqs	392	24	archaea	archaea	NNS
cord-296347-fanlvxqs	392	25	to	to	IN
cord-296347-fanlvxqs	392	26	mammals	mammal	NNS
cord-296347-fanlvxqs	392	27	,	,	,
cord-296347-fanlvxqs	392	28	whose	whose	WP$
cord-296347-fanlvxqs	392	29	functions	function	NNS
cord-296347-fanlvxqs	392	30	include	include	VBP
cord-296347-fanlvxqs	392	31	mitotic	mitotic	JJ
cord-296347-fanlvxqs	392	32	spindle	spindle	NN
cord-296347-fanlvxqs	392	33	disassembly	disassembly	NN
cord-296347-fanlvxqs	392	34	,	,	,
cord-296347-fanlvxqs	392	35	membrane	membrane	NN
cord-296347-fanlvxqs	392	36	traffic	traffic	NN
cord-296347-fanlvxqs	392	37	and	and	CC
cord-296347-fanlvxqs	392	38	fusion	fusion	NN
cord-296347-fanlvxqs	392	39	,	,	,
cord-296347-fanlvxqs	392	40	nucleic	nucleic	JJ
cord-296347-fanlvxqs	392	41	acid	acid	NN
cord-296347-fanlvxqs	392	42	repair	repair	NN
cord-296347-fanlvxqs	392	43	and	and	CC
cord-296347-fanlvxqs	392	44	replication	replication	NN
cord-296347-fanlvxqs	392	45	,	,	,
cord-296347-fanlvxqs	392	46	and	and	CC
cord-296347-fanlvxqs	392	47	Ubproteasome	Ubproteasome	NNP
cord-296347-fanlvxqs	392	48	degradation	degradation	NN
cord-296347-fanlvxqs	392	49	(	(	-LRB-
cord-296347-fanlvxqs	392	50	Woodman	Woodman	NNP
cord-296347-fanlvxqs	392	51	,	,	,
cord-296347-fanlvxqs	392	52	2003	2003	CD
cord-296347-fanlvxqs	392	53	)	)	-RRB-
cord-296347-fanlvxqs	392	54	.	.	.
cord-296347-fanlvxqs	393	1	Cdc48p	Cdc48p	NNP
cord-296347-fanlvxqs	393	2	/	/	SYM
cord-296347-fanlvxqs	393	3	p97	p97	CD
cord-296347-fanlvxqs	393	4	is	be	VBZ
cord-296347-fanlvxqs	393	5	a	a	DT
cord-296347-fanlvxqs	393	6	motor	motor	NN
cord-296347-fanlvxqs	393	7	protein	protein	NN
cord-296347-fanlvxqs	393	8	that	that	WDT
cord-296347-fanlvxqs	393	9	generates	generate	VBZ
cord-296347-fanlvxqs	393	10	energy	energy	NN
cord-296347-fanlvxqs	393	11	from	from	IN
cord-296347-fanlvxqs	393	12	ATP	ATP	NNP
cord-296347-fanlvxqs	393	13	binding	binding	NN
cord-296347-fanlvxqs	393	14	and	and	CC
cord-296347-fanlvxqs	393	15	hydrolysis	hydrolysis	NN
cord-296347-fanlvxqs	393	16	;	;	:
cord-296347-fanlvxqs	393	17	it	-PRON-	PRP
cord-296347-fanlvxqs	393	18	forms	form	VBZ
cord-296347-fanlvxqs	393	19	a	a	DT
cord-296347-fanlvxqs	393	20	homohexameric	homohexameric	JJ
cord-296347-fanlvxqs	393	21	barrel	barrel	NN
cord-296347-fanlvxqs	393	22	structure	structure	NN
cord-296347-fanlvxqs	393	23	,	,	,
cord-296347-fanlvxqs	393	24	with	with	IN
cord-296347-fanlvxqs	393	25	each	each	DT
cord-296347-fanlvxqs	393	26	subunit	subunit	NN
cord-296347-fanlvxqs	393	27	containing	contain	VBG
cord-296347-fanlvxqs	393	28	two	two	CD
cord-296347-fanlvxqs	393	29	AAA	aaa	NN
cord-296347-fanlvxqs	393	30	domains	domain	NNS
cord-296347-fanlvxqs	393	31	that	that	WDT
cord-296347-fanlvxqs	393	32	contain	contain	VBP
cord-296347-fanlvxqs	393	33	the	the	DT
cord-296347-fanlvxqs	393	34	Walker	Walker	NNP
cord-296347-fanlvxqs	393	35	motifs	motif	NNS
cord-296347-fanlvxqs	393	36	essential	essential	JJ
cord-296347-fanlvxqs	393	37	for	for	IN
cord-296347-fanlvxqs	393	38	ATPase	ATPase	NNP
cord-296347-fanlvxqs	393	39	activity	activity	NN
cord-296347-fanlvxqs	393	40	,	,	,
cord-296347-fanlvxqs	393	41	and	and	CC
cord-296347-fanlvxqs	393	42	the	the	DT
cord-296347-fanlvxqs	393	43	6	6	CD
cord-296347-fanlvxqs	393	44	subunits	subunit	NNS
cord-296347-fanlvxqs	393	45	arranged	arrange	VBN
cord-296347-fanlvxqs	393	46	in	in	IN
cord-296347-fanlvxqs	393	47	a	a	DT
cord-296347-fanlvxqs	393	48	ring	ring	NN
cord-296347-fanlvxqs	393	49	with	with	IN
cord-296347-fanlvxqs	393	50	a	a	DT
cord-296347-fanlvxqs	393	51	pore	pore	NN
cord-296347-fanlvxqs	393	52	in	in	IN
cord-296347-fanlvxqs	393	53	the	the	DT
cord-296347-fanlvxqs	393	54	center	center	NN
cord-296347-fanlvxqs	394	1	(	(	-LRB-
cord-296347-fanlvxqs	394	2	Zhang	Zhang	NNP
cord-296347-fanlvxqs	394	3	et	et	NNP
cord-296347-fanlvxqs	394	4	al	al	NNP
cord-296347-fanlvxqs	394	5	.	.	NNP
cord-296347-fanlvxqs	394	6	,	,	,
cord-296347-fanlvxqs	394	7	2000	2000	CD
cord-296347-fanlvxqs	394	8	)	)	-RRB-
cord-296347-fanlvxqs	394	9	.	.	.
cord-296347-fanlvxqs	395	1	Cdc48p	Cdc48p	NNP
cord-296347-fanlvxqs	395	2	/	/	SYM
cord-296347-fanlvxqs	395	3	p97	p97	NN
cord-296347-fanlvxqs	395	4	interacts	interact	VBZ
cord-296347-fanlvxqs	395	5	with	with	IN
cord-296347-fanlvxqs	395	6	many	many	JJ
cord-296347-fanlvxqs	395	7	different	different	JJ
cord-296347-fanlvxqs	395	8	adaptor	adaptor	NN
cord-296347-fanlvxqs	395	9	proteins	protein	NNS
cord-296347-fanlvxqs	395	10	,	,	,
cord-296347-fanlvxqs	395	11	which	which	WDT
cord-296347-fanlvxqs	395	12	regulate	regulate	VBP
cord-296347-fanlvxqs	395	13	its	-PRON-	PRP$
cord-296347-fanlvxqs	395	14	function	function	NN
cord-296347-fanlvxqs	395	15	(	(	-LRB-
cord-296347-fanlvxqs	395	16	Dreveny	Dreveny	NNP
cord-296347-fanlvxqs	395	17	et	et	FW
cord-296347-fanlvxqs	395	18	al	al	NNP
cord-296347-fanlvxqs	395	19	.	.	NNP
cord-296347-fanlvxqs	395	20	,	,	,
cord-296347-fanlvxqs	395	21	2004	2004	CD
cord-296347-fanlvxqs	395	22	)	)	-RRB-
cord-296347-fanlvxqs	395	23	.	.	.
cord-296347-fanlvxqs	396	1	P97	P97	NNP
cord-296347-fanlvxqs	396	2	can	can	MD
cord-296347-fanlvxqs	396	3	recognize	recognize	VB
cord-296347-fanlvxqs	396	4	denatured	denatured	JJ
cord-296347-fanlvxqs	396	5	proteins	protein	NNS
cord-296347-fanlvxqs	396	6	nonspecifically	nonspecifically	RB
cord-296347-fanlvxqs	396	7	(	(	-LRB-
cord-296347-fanlvxqs	396	8	Thoms	Thoms	NNP
cord-296347-fanlvxqs	396	9	,	,	,
cord-296347-fanlvxqs	396	10	2002	2002	CD
cord-296347-fanlvxqs	396	11	)	)	-RRB-
cord-296347-fanlvxqs	396	12	and	and	CC
cord-296347-fanlvxqs	396	13	has	have	VBZ
cord-296347-fanlvxqs	396	14	an	an	DT
cord-296347-fanlvxqs	396	15	affinity	affinity	NN
cord-296347-fanlvxqs	396	16	for	for	IN
cord-296347-fanlvxqs	396	17	polyubiquitin	polyubiquitin	NNP
cord-296347-fanlvxqs	396	18	chains	chain	NNS
cord-296347-fanlvxqs	396	19	.	.	.
cord-296347-fanlvxqs	397	1	When	when	WRB
cord-296347-fanlvxqs	397	2	complexed	complexe	VBN
cord-296347-fanlvxqs	397	3	with	with	IN
cord-296347-fanlvxqs	397	4	the	the	DT
cord-296347-fanlvxqs	397	5	polyUb	polyub	NN
cord-296347-fanlvxqs	397	6	-	-	HYPH
cord-296347-fanlvxqs	397	7	binding	bind	VBG
cord-296347-fanlvxqs	397	8	Ufd1p	ufd1p	NN
cord-296347-fanlvxqs	397	9	and	and	CC
cord-296347-fanlvxqs	397	10	Npl4p	Npl4p	NNP
cord-296347-fanlvxqs	397	11	,	,	,
cord-296347-fanlvxqs	397	12	Cdc48p	Cdc48p	NNP
cord-296347-fanlvxqs	397	13	/	/	SYM
cord-296347-fanlvxqs	397	14	p97	p97	CD
cord-296347-fanlvxqs	397	15	activity	activity	NN
cord-296347-fanlvxqs	397	16	is	be	VBZ
cord-296347-fanlvxqs	397	17	directed	direct	VBN
cord-296347-fanlvxqs	397	18	to	to	IN
cord-296347-fanlvxqs	397	19	ER	ER	NNP
cord-296347-fanlvxqs	397	20	degradation	degradation	NN
cord-296347-fanlvxqs	397	21	(	(	-LRB-
cord-296347-fanlvxqs	397	22	Ye	Ye	NNP
cord-296347-fanlvxqs	397	23	et	et	NNP
cord-296347-fanlvxqs	397	24	al	al	NNP
cord-296347-fanlvxqs	397	25	.	.	NNP
cord-296347-fanlvxqs	397	26	,	,	,
cord-296347-fanlvxqs	397	27	2001	2001	CD
cord-296347-fanlvxqs	397	28	)	)	-RRB-
cord-296347-fanlvxqs	397	29	.	.	.
cord-296347-fanlvxqs	398	1	Both	both	DT
cord-296347-fanlvxqs	398	2	in	in	IN
cord-296347-fanlvxqs	398	3	yeast	yeast	NN
cord-296347-fanlvxqs	398	4	and	and	CC
cord-296347-fanlvxqs	398	5	in	in	IN
cord-296347-fanlvxqs	398	6	mammals	mammal	NNS
cord-296347-fanlvxqs	398	7	,	,	,
cord-296347-fanlvxqs	398	8	the	the	DT
cord-296347-fanlvxqs	398	9	trimeric	trimeric	NNP
cord-296347-fanlvxqs	398	10	Cdc48p(p97)/NPL4	Cdc48p(p97)/NPL4	NNP
cord-296347-fanlvxqs	398	11	/	/	SYM
cord-296347-fanlvxqs	398	12	UFD1	UFD1	NNP
cord-296347-fanlvxqs	398	13	complex	complex	NN
cord-296347-fanlvxqs	398	14	is	be	VBZ
cord-296347-fanlvxqs	398	15	proposed	propose	VBN
cord-296347-fanlvxqs	398	16	to	to	TO
cord-296347-fanlvxqs	398	17	function	function	VB
cord-296347-fanlvxqs	398	18	in	in	IN
cord-296347-fanlvxqs	398	19	a	a	DT
cord-296347-fanlvxqs	398	20	postubiquitination	postubiquitination	NN
cord-296347-fanlvxqs	398	21	,	,	,
cord-296347-fanlvxqs	398	22	preproteasomal	preproteasomal	JJ
cord-296347-fanlvxqs	398	23	step	step	NN
cord-296347-fanlvxqs	398	24	(	(	-LRB-
cord-296347-fanlvxqs	398	25	Bays	Bays	NNPS
cord-296347-fanlvxqs	398	26	and	and	CC
cord-296347-fanlvxqs	398	27	Hampton	Hampton	NNP
cord-296347-fanlvxqs	398	28	,	,	,
cord-296347-fanlvxqs	398	29	2002	2002	CD
cord-296347-fanlvxqs	398	30	;	;	:
cord-296347-fanlvxqs	399	1	Jarosch	Jarosch	NNP
cord-296347-fanlvxqs	399	2	et	et	NNP
cord-296347-fanlvxqs	399	3	al	al	NNP
cord-296347-fanlvxqs	399	4	.	.	NNP
cord-296347-fanlvxqs	399	5	,	,	,
cord-296347-fanlvxqs	399	6	2002	2002	CD
cord-296347-fanlvxqs	399	7	)	)	-RRB-
cord-296347-fanlvxqs	399	8	,	,	,
cord-296347-fanlvxqs	399	9	in	in	IN
cord-296347-fanlvxqs	399	10	one	one	CD
cord-296347-fanlvxqs	399	11	of	of	IN
cord-296347-fanlvxqs	399	12	two	two	CD
cord-296347-fanlvxqs	399	13	fashions	fashion	NNS
cord-296347-fanlvxqs	399	14	:	:	:
cord-296347-fanlvxqs	399	15	the	the	DT
cord-296347-fanlvxqs	399	16	ATP	ATP	NNP
cord-296347-fanlvxqs	399	17	-	-	HYPH
cord-296347-fanlvxqs	399	18	hydrolytic	hydrolytic	JJ
cord-296347-fanlvxqs	399	19	activity	activity	NN
cord-296347-fanlvxqs	399	20	of	of	IN
cord-296347-fanlvxqs	399	21	the	the	DT
cord-296347-fanlvxqs	399	22	AAA	AAA	NNP
cord-296347-fanlvxqs	399	23	ATPase	ATPase	NNP
cord-296347-fanlvxqs	399	24	p97	p97	CD
cord-296347-fanlvxqs	399	25	may	may	MD
cord-296347-fanlvxqs	399	26	provide	provide	VB
cord-296347-fanlvxqs	399	27	the	the	DT
cord-296347-fanlvxqs	399	28	driving	drive	VBG
cord-296347-fanlvxqs	399	29	force	force	NN
cord-296347-fanlvxqs	399	30	to	to	TO
cord-296347-fanlvxqs	399	31	extract	extract	VB
cord-296347-fanlvxqs	399	32	substrates	substrate	NNS
cord-296347-fanlvxqs	399	33	through	through	IN
cord-296347-fanlvxqs	399	34	the	the	DT
cord-296347-fanlvxqs	399	35	ER	ER	NNP
cord-296347-fanlvxqs	399	36	membrane	membrane	NN
cord-296347-fanlvxqs	399	37	,	,	,
cord-296347-fanlvxqs	399	38	or	or	CC
cord-296347-fanlvxqs	399	39	may	may	MD
cord-296347-fanlvxqs	399	40	be	be	VB
cord-296347-fanlvxqs	399	41	required	require	VBN
cord-296347-fanlvxqs	399	42	to	to	TO
cord-296347-fanlvxqs	399	43	liberate	liberate	VB
cord-296347-fanlvxqs	399	44	already	already	RB
cord-296347-fanlvxqs	399	45	dislocated	dislocate	VBN
cord-296347-fanlvxqs	399	46	substrates	substrate	NNS
cord-296347-fanlvxqs	399	47	from	from	IN
cord-296347-fanlvxqs	399	48	the	the	DT
cord-296347-fanlvxqs	399	49	cytosolic	cytosolic	JJ
cord-296347-fanlvxqs	399	50	face	face	NN
cord-296347-fanlvxqs	399	51	of	of	IN
cord-296347-fanlvxqs	399	52	the	the	DT
cord-296347-fanlvxqs	399	53	ER	ER	NNP
cord-296347-fanlvxqs	399	54	membrane	membrane	NN
cord-296347-fanlvxqs	400	1	(	(	-LRB-
cord-296347-fanlvxqs	400	2	Braun	Braun	NNP
cord-296347-fanlvxqs	400	3	et	et	NNP
cord-296347-fanlvxqs	400	4	al	al	NNP
cord-296347-fanlvxqs	400	5	.	.	.
cord-296347-fanlvxqs	401	1	,	,	,
cord-296347-fanlvxqs	401	2	2002	2002	CD
cord-296347-fanlvxqs	401	3	;	;	:
cord-296347-fanlvxqs	401	4	Flierman	Flierman	NNP
cord-296347-fanlvxqs	401	5	et	et	NNP
cord-296347-fanlvxqs	401	6	al	al	NNP
cord-296347-fanlvxqs	401	7	.	.	NNP
cord-296347-fanlvxqs	401	8	,	,	,
cord-296347-fanlvxqs	401	9	2003	2003	CD
cord-296347-fanlvxqs	401	10	;	;	:
cord-296347-fanlvxqs	401	11	Hirsch	Hirsch	NNP
cord-296347-fanlvxqs	401	12	et	et	NNP
cord-296347-fanlvxqs	401	13	al	al	NNP
cord-296347-fanlvxqs	401	14	.	.	NNP
cord-296347-fanlvxqs	401	15	,	,	,
cord-296347-fanlvxqs	401	16	2004	2004	CD
cord-296347-fanlvxqs	401	17	;	;	:
cord-296347-fanlvxqs	401	18	Kostova	Kostova	NNP
cord-296347-fanlvxqs	401	19	and	and	CC
cord-296347-fanlvxqs	401	20	Wolf	Wolf	NNP
cord-296347-fanlvxqs	401	21	,	,	,
cord-296347-fanlvxqs	401	22	2003	2003	CD
cord-296347-fanlvxqs	401	23	;	;	:
cord-296347-fanlvxqs	401	24	Meusser	Meusser	NNP
cord-296347-fanlvxqs	401	25	et	et	NNP
cord-296347-fanlvxqs	401	26	al	al	NNP
cord-296347-fanlvxqs	401	27	.	.	NNP
cord-296347-fanlvxqs	401	28	,	,	,
cord-296347-fanlvxqs	401	29	2005	2005	CD
cord-296347-fanlvxqs	401	30	)	)	-RRB-
cord-296347-fanlvxqs	401	31	.	.	.
cord-296347-fanlvxqs	402	1	The	the	DT
cord-296347-fanlvxqs	402	2	proteasome	proteasome	NN
cord-296347-fanlvxqs	402	3	presumably	presumably	RB
cord-296347-fanlvxqs	402	4	interacts	interact	VBZ
cord-296347-fanlvxqs	402	5	with	with	IN
cord-296347-fanlvxqs	402	6	the	the	DT
cord-296347-fanlvxqs	402	7	ER	ER	NNP
cord-296347-fanlvxqs	402	8	membrane	membrane	NN
cord-296347-fanlvxqs	402	9	(	(	-LRB-
cord-296347-fanlvxqs	402	10	Hirsch	Hirsch	NNP
cord-296347-fanlvxqs	402	11	and	and	CC
cord-296347-fanlvxqs	402	12	Ploegh	Ploegh	NNP
cord-296347-fanlvxqs	402	13	,	,	,
cord-296347-fanlvxqs	402	14	2000	2000	CD
cord-296347-fanlvxqs	402	15	)	)	-RRB-
cord-296347-fanlvxqs	402	16	,	,	,
cord-296347-fanlvxqs	402	17	either	either	CC
cord-296347-fanlvxqs	402	18	directly	directly	RB
cord-296347-fanlvxqs	402	19	or	or	CC
cord-296347-fanlvxqs	402	20	through	through	IN
cord-296347-fanlvxqs	402	21	a	a	DT
cord-296347-fanlvxqs	402	22	receptor	receptor	NN
cord-296347-fanlvxqs	402	23	that	that	WDT
cord-296347-fanlvxqs	402	24	docks	dock	VBZ
cord-296347-fanlvxqs	402	25	the	the	DT
cord-296347-fanlvxqs	402	26	proteasome	proteasome	NN
cord-296347-fanlvxqs	402	27	to	to	IN
cord-296347-fanlvxqs	402	28	the	the	DT
cord-296347-fanlvxqs	402	29	ER	ER	NNP
cord-296347-fanlvxqs	402	30	membrane	membrane	NN
cord-296347-fanlvxqs	402	31	,	,	,
cord-296347-fanlvxqs	402	32	perhaps	perhaps	RB
cord-296347-fanlvxqs	402	33	Sec61	Sec61	NNP
cord-296347-fanlvxqs	402	34	(	(	-LRB-
cord-296347-fanlvxqs	402	35	Kalies	Kalies	NNP
cord-296347-fanlvxqs	402	36	et	et	NNP
cord-296347-fanlvxqs	402	37	al	al	NNP
cord-296347-fanlvxqs	402	38	.	.	NNP
cord-296347-fanlvxqs	402	39	,	,	,
cord-296347-fanlvxqs	402	40	2005	2005	CD
cord-296347-fanlvxqs	402	41	)	)	-RRB-
cord-296347-fanlvxqs	402	42	.	.	.
cord-296347-fanlvxqs	403	1	Notwithstanding	notwithstanding	IN
cord-296347-fanlvxqs	403	2	,	,	,
cord-296347-fanlvxqs	403	3	the	the	DT
cord-296347-fanlvxqs	403	4	Cdc48p(p97)/NPL4	Cdc48p(p97)/NPL4	NNP
cord-296347-fanlvxqs	403	5	/	/	SYM
cord-296347-fanlvxqs	403	6	UFD1	ufd1	JJ
cord-296347-fanlvxqs	403	7	complex	complex	NN
cord-296347-fanlvxqs	403	8	or	or	CC
cord-296347-fanlvxqs	403	9	other	other	JJ
cord-296347-fanlvxqs	403	10	accessory	accessory	NN
cord-296347-fanlvxqs	403	11	factors	factor	NNS
cord-296347-fanlvxqs	403	12	might	may	MD
cord-296347-fanlvxqs	403	13	aid	aid	VB
cord-296347-fanlvxqs	403	14	substrate	substrate	NN
cord-296347-fanlvxqs	403	15	feeding	feed	VBG
cord-296347-fanlvxqs	403	16	to	to	IN
cord-296347-fanlvxqs	403	17	the	the	DT
cord-296347-fanlvxqs	403	18	proteasome	proteasome	NN
cord-296347-fanlvxqs	404	1	(	(	-LRB-
cord-296347-fanlvxqs	404	2	Hartmann	Hartmann	NNP
cord-296347-fanlvxqs	404	3	-	-	HYPH
cord-296347-fanlvxqs	404	4	Petersen	Petersen	NNP
cord-296347-fanlvxqs	404	5	and	and	CC
cord-296347-fanlvxqs	404	6	Gordon	Gordon	NNP
cord-296347-fanlvxqs	404	7	,	,	,
cord-296347-fanlvxqs	404	8	2004a	2004a	CD
cord-296347-fanlvxqs	404	9	;	;	:
cord-296347-fanlvxqs	405	1	Richly	richly	RB
cord-296347-fanlvxqs	405	2	et	et	NNP
cord-296347-fanlvxqs	405	3	al	al	NNP
cord-296347-fanlvxqs	405	4	.	.	NNP
cord-296347-fanlvxqs	405	5	,	,	,
cord-296347-fanlvxqs	405	6	2005	2005	CD
cord-296347-fanlvxqs	405	7	)	)	-RRB-
cord-296347-fanlvxqs	405	8	.	.	.
cord-296347-fanlvxqs	406	1	Ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	406	2	-	-	HYPH
cord-296347-fanlvxqs	406	3	binding	bind	VBG
cord-296347-fanlvxqs	406	4	factors	factor	NNS
cord-296347-fanlvxqs	406	5	,	,	,
cord-296347-fanlvxqs	406	6	such	such	JJ
cord-296347-fanlvxqs	406	7	as	as	IN
cord-296347-fanlvxqs	406	8	Rad23p	Rad23p	NNP
cord-296347-fanlvxqs	406	9	and	and	CC
cord-296347-fanlvxqs	406	10	Dsk2p	Dsk2p	NNPS
cord-296347-fanlvxqs	406	11	(	(	-LRB-
cord-296347-fanlvxqs	406	12	in	in	IN
cord-296347-fanlvxqs	406	13	yeast	yeast	NN
cord-296347-fanlvxqs	406	14	)	)	-RRB-
cord-296347-fanlvxqs	406	15	,	,	,
cord-296347-fanlvxqs	406	16	have	have	VBP
cord-296347-fanlvxqs	406	17	a	a	DT
cord-296347-fanlvxqs	406	18	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	406	19	-	-	HYPH
cord-296347-fanlvxqs	406	20	associated	associated	JJ
cord-296347-fanlvxqs	406	21	(	(	-LRB-
cord-296347-fanlvxqs	406	22	UBA	UBA	NNP
cord-296347-fanlvxqs	406	23	)	)	-RRB-
cord-296347-fanlvxqs	406	24	motif	motif	NN
cord-296347-fanlvxqs	406	25	that	that	WDT
cord-296347-fanlvxqs	406	26	binds	bind	VBZ
cord-296347-fanlvxqs	406	27	polyubiquitin	polyubiquitin	NNP
cord-296347-fanlvxqs	406	28	chains	chain	NNS
cord-296347-fanlvxqs	406	29	and	and	CC
cord-296347-fanlvxqs	406	30	a	a	DT
cord-296347-fanlvxqs	406	31	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	406	32	-	-	HYPH
cord-296347-fanlvxqs	406	33	like	like	JJ
cord-296347-fanlvxqs	406	34	(	(	-LRB-
cord-296347-fanlvxqs	406	35	UBL	UBL	NNP
cord-296347-fanlvxqs	406	36	)	)	-RRB-
cord-296347-fanlvxqs	406	37	motif	motif	NN
cord-296347-fanlvxqs	406	38	that	that	WDT
cord-296347-fanlvxqs	406	39	binds	bind	VBZ
cord-296347-fanlvxqs	406	40	to	to	IN
cord-296347-fanlvxqs	406	41	the	the	DT
cord-296347-fanlvxqs	406	42	19S	19s	CD
cord-296347-fanlvxqs	406	43	proteasome	proteasome	NN
cord-296347-fanlvxqs	406	44	,	,	,
cord-296347-fanlvxqs	406	45	and	and	CC
cord-296347-fanlvxqs	406	46	these	these	DT
cord-296347-fanlvxqs	406	47	are	be	VBP
cord-296347-fanlvxqs	406	48	required	require	VBN
cord-296347-fanlvxqs	406	49	for	for	IN
cord-296347-fanlvxqs	406	50	efficient	efficient	JJ
cord-296347-fanlvxqs	406	51	degradation	degradation	NN
cord-296347-fanlvxqs	406	52	of	of	IN
cord-296347-fanlvxqs	406	53	a	a	DT
cord-296347-fanlvxqs	406	54	model	model	NN
cord-296347-fanlvxqs	406	55	ERAD	ERAD	NNP
cord-296347-fanlvxqs	406	56	substrate	substrate	NN
cord-296347-fanlvxqs	406	57	(	(	-LRB-
cord-296347-fanlvxqs	406	58	Elsasser	Elsasser	NNP
cord-296347-fanlvxqs	406	59	et	et	FW
cord-296347-fanlvxqs	406	60	al	al	NNP
cord-296347-fanlvxqs	406	61	.	.	NNP
cord-296347-fanlvxqs	406	62	,	,	,
cord-296347-fanlvxqs	406	63	2004	2004	CD
cord-296347-fanlvxqs	406	64	;	;	:
cord-296347-fanlvxqs	406	65	Schauber	Schauber	NNP
cord-296347-fanlvxqs	406	66	et	et	NNP
cord-296347-fanlvxqs	406	67	al	al	NNP
cord-296347-fanlvxqs	406	68	.	.	NNP
cord-296347-fanlvxqs	406	69	,	,	,
cord-296347-fanlvxqs	406	70	1998	1998	CD
cord-296347-fanlvxqs	406	71	;	;	:
cord-296347-fanlvxqs	406	72	Wilkinson	Wilkinson	NNP
cord-296347-fanlvxqs	406	73	et	et	NNP
cord-296347-fanlvxqs	406	74	al	al	NNP
cord-296347-fanlvxqs	406	75	.	.	NNP
cord-296347-fanlvxqs	406	76	,	,	,
cord-296347-fanlvxqs	406	77	2001	2001	CD
cord-296347-fanlvxqs	406	78	)	)	-RRB-
cord-296347-fanlvxqs	406	79	.	.	.
cord-296347-fanlvxqs	407	1	The	the	DT
cord-296347-fanlvxqs	407	2	yeast	yeast	NN
cord-296347-fanlvxqs	407	3	Ub	Ub	NNP
cord-296347-fanlvxqs	407	4	regulatory	regulatory	JJ
cord-296347-fanlvxqs	407	5	X	x	NN
cord-296347-fanlvxqs	407	6	domain	domain	NN
cord-296347-fanlvxqs	407	7	-	-	HYPH
cord-296347-fanlvxqs	407	8	containing	contain	VBG
cord-296347-fanlvxqs	407	9	Ubx2p	Ubx2p	NNP
cord-296347-fanlvxqs	407	10	/	/	SYM
cord-296347-fanlvxqs	407	11	Sel1p	Sel1p	NNP
cord-296347-fanlvxqs	407	12	protein	protein	NN
cord-296347-fanlvxqs	407	13	,	,	,
cord-296347-fanlvxqs	407	14	an	an	DT
cord-296347-fanlvxqs	407	15	integral	integral	JJ
cord-296347-fanlvxqs	407	16	ER	ER	NNP
cord-296347-fanlvxqs	407	17	membrane	membrane	NN
cord-296347-fanlvxqs	407	18	protein	protein	NN
cord-296347-fanlvxqs	407	19	,	,	,
cord-296347-fanlvxqs	407	20	was	be	VBD
cord-296347-fanlvxqs	407	21	recently	recently	RB
cord-296347-fanlvxqs	407	22	shown	show	VBN
cord-296347-fanlvxqs	407	23	to	to	TO
cord-296347-fanlvxqs	407	24	recruit	recruit	VB
cord-296347-fanlvxqs	407	25	the	the	DT
cord-296347-fanlvxqs	407	26	Cdc48p	Cdc48p	NNP
cord-296347-fanlvxqs	407	27	/	/	SYM
cord-296347-fanlvxqs	407	28	Npl4p	Npl4p	NNP
cord-296347-fanlvxqs	407	29	/	/	SYM
cord-296347-fanlvxqs	407	30	Ufd1p	ufd1p	IN
cord-296347-fanlvxqs	407	31	complex	complex	JJ
cord-296347-fanlvxqs	407	32	to	to	IN
cord-296347-fanlvxqs	407	33	the	the	DT
cord-296347-fanlvxqs	407	34	ER	ER	NNP
cord-296347-fanlvxqs	407	35	membrane	membrane	NN
cord-296347-fanlvxqs	407	36	,	,	,
cord-296347-fanlvxqs	407	37	thereby	thereby	RB
cord-296347-fanlvxqs	407	38	facilitating	facilitate	VBG
cord-296347-fanlvxqs	407	39	the	the	DT
cord-296347-fanlvxqs	407	40	transfer	transfer	NN
cord-296347-fanlvxqs	407	41	of	of	IN
cord-296347-fanlvxqs	407	42	polyubiquitinated	polyubiquitinated	JJ
cord-296347-fanlvxqs	407	43	substrates	substrate	NNS
cord-296347-fanlvxqs	407	44	from	from	IN
cord-296347-fanlvxqs	407	45	the	the	DT
cord-296347-fanlvxqs	407	46	E3	E3	NNP
cord-296347-fanlvxqs	407	47	ligases	ligase	NNS
cord-296347-fanlvxqs	407	48	Hrd1p	Hrd1p	NNP
cord-296347-fanlvxqs	407	49	and	and	CC
cord-296347-fanlvxqs	407	50	Doa10p	doa10p	CD
cord-296347-fanlvxqs	407	51	to	to	IN
cord-296347-fanlvxqs	407	52	Cdc48	Cdc48	NNP
cord-296347-fanlvxqs	407	53	/	/	SYM
cord-296347-fanlvxqs	407	54	p97	p97	CD
cord-296347-fanlvxqs	407	55	(	(	-LRB-
cord-296347-fanlvxqs	407	56	Neuber	Neuber	NNP
cord-296347-fanlvxqs	407	57	et	et	NNP
cord-296347-fanlvxqs	407	58	al	al	NNP
cord-296347-fanlvxqs	407	59	.	.	NNP
cord-296347-fanlvxqs	407	60	,	,	,
cord-296347-fanlvxqs	407	61	2005	2005	CD
cord-296347-fanlvxqs	407	62	;	;	:
cord-296347-fanlvxqs	407	63	Schuberth	Schuberth	NNP
cord-296347-fanlvxqs	407	64	and	and	CC
cord-296347-fanlvxqs	407	65	Buchberger	Buchberger	NNP
cord-296347-fanlvxqs	407	66	,	,	,
cord-296347-fanlvxqs	407	67	2005	2005	CD
cord-296347-fanlvxqs	407	68	)	)	-RRB-
cord-296347-fanlvxqs	407	69	.	.	.
cord-296347-fanlvxqs	408	1	These	these	DT
cord-296347-fanlvxqs	408	2	dual	dual	JJ
cord-296347-fanlvxqs	408	3	function	function	NN
cord-296347-fanlvxqs	408	4	Ub	Ub	NNP
cord-296347-fanlvxqs	408	5	-	-	HYPH
cord-296347-fanlvxqs	408	6	binding	bind	VBG
cord-296347-fanlvxqs	408	7	factors	factor	NNS
cord-296347-fanlvxqs	408	8	effectively	effectively	RB
cord-296347-fanlvxqs	408	9	serve	serve	VBP
cord-296347-fanlvxqs	408	10	as	as	IN
cord-296347-fanlvxqs	408	11	bridges	bridge	NNS
cord-296347-fanlvxqs	408	12	between	between	IN
cord-296347-fanlvxqs	408	13	the	the	DT
cord-296347-fanlvxqs	408	14	p97	p97	CD
cord-296347-fanlvxqs	408	15	/	/	SYM
cord-296347-fanlvxqs	408	16	NPL4	NPL4	NNP
cord-296347-fanlvxqs	408	17	/	/	SYM
cord-296347-fanlvxqs	408	18	UFD1	UFD1	NNP
cord-296347-fanlvxqs	408	19	complex	complex	NN
cord-296347-fanlvxqs	408	20	and	and	CC
cord-296347-fanlvxqs	408	21	the	the	DT
cord-296347-fanlvxqs	408	22	proteasome	proteasome	NN
cord-296347-fanlvxqs	408	23	.	.	.
cord-296347-fanlvxqs	409	1	As	as	IN
cord-296347-fanlvxqs	409	2	more	more	JJR
cord-296347-fanlvxqs	409	3	of	of	IN
cord-296347-fanlvxqs	409	4	these	these	DT
cord-296347-fanlvxqs	409	5	Ub	Ub	NNP
cord-296347-fanlvxqs	409	6	-	-	HYPH
cord-296347-fanlvxqs	409	7	and	and	CC
cord-296347-fanlvxqs	409	8	proteasome	proteasome	NN
cord-296347-fanlvxqs	409	9	-	-	HYPH
cord-296347-fanlvxqs	409	10	binding	bind	VBG
cord-296347-fanlvxqs	409	11	proteins	protein	NNS
cord-296347-fanlvxqs	409	12	are	be	VBP
cord-296347-fanlvxqs	409	13	discovered	discover	VBN
cord-296347-fanlvxqs	409	14	(	(	-LRB-
cord-296347-fanlvxqs	409	15	Buschhorn	Buschhorn	NNP
cord-296347-fanlvxqs	409	16	et	et	NNP
cord-296347-fanlvxqs	409	17	al	al	NNP
cord-296347-fanlvxqs	409	18	.	.	NNP
cord-296347-fanlvxqs	409	19	,	,	,
cord-296347-fanlvxqs	409	20	2004	2004	CD
cord-296347-fanlvxqs	409	21	;	;	:
cord-296347-fanlvxqs	410	1	Decottignies	Decottignies	NNP
cord-296347-fanlvxqs	410	2	et	et	NNP
cord-296347-fanlvxqs	410	3	al	al	NNP
cord-296347-fanlvxqs	410	4	.	.	NNP
cord-296347-fanlvxqs	410	5	,	,	,
cord-296347-fanlvxqs	410	6	2004	2004	CD
cord-296347-fanlvxqs	411	1	;	;	:
cord-296347-fanlvxqs	411	2	Medicherla	Medicherla	NNP
cord-296347-fanlvxqs	411	3	et	et	NNP
cord-296347-fanlvxqs	411	4	al	al	NNP
cord-296347-fanlvxqs	411	5	.	.	NNP
cord-296347-fanlvxqs	411	6	,	,	,
cord-296347-fanlvxqs	411	7	2004	2004	CD
cord-296347-fanlvxqs	411	8	;	;	:
cord-296347-fanlvxqs	411	9	Mullally	Mullally	NNP
cord-296347-fanlvxqs	411	10	et	et	NNP
cord-296347-fanlvxqs	411	11	al	al	NNP
cord-296347-fanlvxqs	411	12	.	.	NNP
cord-296347-fanlvxqs	411	13	,	,	,
cord-296347-fanlvxqs	411	14	2006	2006	CD
cord-296347-fanlvxqs	411	15	)	)	-RRB-
cord-296347-fanlvxqs	411	16	,	,	,
cord-296347-fanlvxqs	411	17	a	a	DT
cord-296347-fanlvxqs	411	18	'	'	''
cord-296347-fanlvxqs	411	19	'	'	``
cord-296347-fanlvxqs	411	20	guidance	guidance	NN
cord-296347-fanlvxqs	411	21	'	'	''
cord-296347-fanlvxqs	411	22	'	'	''
cord-296347-fanlvxqs	411	23	model	model	NN
cord-296347-fanlvxqs	411	24	,	,	,
cord-296347-fanlvxqs	411	25	in	in	IN
cord-296347-fanlvxqs	411	26	which	which	WDT
cord-296347-fanlvxqs	411	27	ERAD	ERAD	NNP
cord-296347-fanlvxqs	411	28	substrates	substrate	NNS
cord-296347-fanlvxqs	411	29	are	be	VBP
cord-296347-fanlvxqs	411	30	escorted	escort	VBN
cord-296347-fanlvxqs	411	31	from	from	IN
cord-296347-fanlvxqs	411	32	a	a	DT
cord-296347-fanlvxqs	411	33	dislocation	dislocation	NN
cord-296347-fanlvxqs	411	34	channel	channel	NN
cord-296347-fanlvxqs	411	35	to	to	IN
cord-296347-fanlvxqs	411	36	the	the	DT
cord-296347-fanlvxqs	411	37	proteasome	proteasome	NN
cord-296347-fanlvxqs	411	38	by	by	IN
cord-296347-fanlvxqs	411	39	a	a	DT
cord-296347-fanlvxqs	411	40	cascade	cascade	NN
cord-296347-fanlvxqs	411	41	of	of	IN
cord-296347-fanlvxqs	411	42	Ub	Ub	NNP
cord-296347-fanlvxqs	411	43	-	-	HYPH
cord-296347-fanlvxqs	411	44	binding	bind	VBG
cord-296347-fanlvxqs	411	45	factors	factor	NNS
cord-296347-fanlvxqs	411	46	,	,	,
cord-296347-fanlvxqs	411	47	gains	gain	NNS
cord-296347-fanlvxqs	411	48	strength	strength	NN
cord-296347-fanlvxqs	411	49	(	(	-LRB-
cord-296347-fanlvxqs	411	50	Hartmann	Hartmann	NNP
cord-296347-fanlvxqs	411	51	-	-	HYPH
cord-296347-fanlvxqs	411	52	Petersen	Petersen	NNP
cord-296347-fanlvxqs	411	53	and	and	CC
cord-296347-fanlvxqs	411	54	Gordon	Gordon	NNP
cord-296347-fanlvxqs	411	55	,	,	,
cord-296347-fanlvxqs	411	56	2004b	2004b	CD
cord-296347-fanlvxqs	412	1	;	;	:
cord-296347-fanlvxqs	412	2	Hartmann	Hartmann	NNP
cord-296347-fanlvxqs	412	3	-	-	HYPH
cord-296347-fanlvxqs	412	4	Petersen	Petersen	NNP
cord-296347-fanlvxqs	412	5	et	et	NNP
cord-296347-fanlvxqs	412	6	al	al	NNP
cord-296347-fanlvxqs	412	7	.	.	.
cord-296347-fanlvxqs	413	1	,	,	,
cord-296347-fanlvxqs	413	2	2003	2003	CD
cord-296347-fanlvxqs	413	3	;	;	:
cord-296347-fanlvxqs	413	4	Hendil	Hendil	NNP
cord-296347-fanlvxqs	413	5	and	and	CC
cord-296347-fanlvxqs	413	6	Hartmann	Hartmann	NNP
cord-296347-fanlvxqs	413	7	-	-	HYPH
cord-296347-fanlvxqs	413	8	Petersen	Petersen	NNP
cord-296347-fanlvxqs	413	9	,	,	,
cord-296347-fanlvxqs	413	10	2004	2004	CD
cord-296347-fanlvxqs	413	11	;	;	:
cord-296347-fanlvxqs	413	12	Richly	richly	RB
cord-296347-fanlvxqs	413	13	et	et	FW
cord-296347-fanlvxqs	413	14	al	al	NNP
cord-296347-fanlvxqs	413	15	.	.	NNP
cord-296347-fanlvxqs	413	16	,	,	,
cord-296347-fanlvxqs	413	17	2005	2005	CD
cord-296347-fanlvxqs	413	18	)	)	-RRB-
cord-296347-fanlvxqs	413	19	.	.	.
cord-296347-fanlvxqs	414	1	These	these	DT
cord-296347-fanlvxqs	414	2	interactions	interaction	NNS
cord-296347-fanlvxqs	414	3	could	could	MD
cord-296347-fanlvxqs	414	4	be	be	VB
cord-296347-fanlvxqs	414	5	responsible	responsible	JJ
cord-296347-fanlvxqs	414	6	for	for	IN
cord-296347-fanlvxqs	414	7	maintaining	maintain	VBG
cord-296347-fanlvxqs	414	8	the	the	DT
cord-296347-fanlvxqs	414	9	substrate	substrate	NN
cord-296347-fanlvxqs	414	10	in	in	IN
cord-296347-fanlvxqs	414	11	a	a	DT
cord-296347-fanlvxqs	414	12	proteolysis	proteolysis	NN
cord-296347-fanlvxqs	414	13	-	-	HYPH
cord-296347-fanlvxqs	414	14	competent	competent	JJ
cord-296347-fanlvxqs	414	15	state	state	NN
cord-296347-fanlvxqs	414	16	and	and	CC
cord-296347-fanlvxqs	414	17	protect	protect	VB
cord-296347-fanlvxqs	414	18	it	-PRON-	PRP
cord-296347-fanlvxqs	414	19	from	from	IN
cord-296347-fanlvxqs	414	20	premature	premature	JJ
cord-296347-fanlvxqs	414	21	deubiquitination	deubiquitination	NN
cord-296347-fanlvxqs	414	22	,	,	,
cord-296347-fanlvxqs	414	23	as	as	RB
cord-296347-fanlvxqs	414	24	well	well	RB
cord-296347-fanlvxqs	414	25	as	as	IN
cord-296347-fanlvxqs	414	26	contribute	contribute	NN
cord-296347-fanlvxqs	414	27	to	to	IN
cord-296347-fanlvxqs	414	28	directionality	directionality	NN
cord-296347-fanlvxqs	414	29	of	of	IN
cord-296347-fanlvxqs	414	30	dislocation	dislocation	NN
cord-296347-fanlvxqs	414	31	(	(	-LRB-
cord-296347-fanlvxqs	414	32	Hendil	Hendil	NNP
cord-296347-fanlvxqs	414	33	and	and	CC
cord-296347-fanlvxqs	414	34	Hartmann	Hartmann	NNP
cord-296347-fanlvxqs	414	35	-	-	HYPH
cord-296347-fanlvxqs	414	36	Petersen	Petersen	NNP
cord-296347-fanlvxqs	414	37	,	,	,
cord-296347-fanlvxqs	414	38	2004	2004	CD
cord-296347-fanlvxqs	414	39	;	;	:
cord-296347-fanlvxqs	414	40	Meusser	Meusser	NNP
cord-296347-fanlvxqs	414	41	et	et	NNP
cord-296347-fanlvxqs	414	42	al	al	NNP
cord-296347-fanlvxqs	414	43	.	.	.
cord-296347-fanlvxqs	415	1	,	,	,
cord-296347-fanlvxqs	415	2	2005	2005	CD
cord-296347-fanlvxqs	415	3	;	;	:
cord-296347-fanlvxqs	415	4	Romisch	Romisch	NNP
cord-296347-fanlvxqs	415	5	,	,	,
cord-296347-fanlvxqs	415	6	2006	2006	CD
cord-296347-fanlvxqs	415	7	)	)	-RRB-
cord-296347-fanlvxqs	415	8	.	.	.
cord-296347-fanlvxqs	416	1	In	in	IN
cord-296347-fanlvxqs	416	2	fact	fact	NN
cord-296347-fanlvxqs	416	3	,	,	,
cord-296347-fanlvxqs	416	4	it	-PRON-	PRP
cord-296347-fanlvxqs	416	5	seems	seem	VBZ
cord-296347-fanlvxqs	416	6	Cdc48p	Cdc48p	NNP
cord-296347-fanlvxqs	416	7	/	/	SYM
cord-296347-fanlvxqs	416	8	p97	p97	CD
cord-296347-fanlvxqs	416	9	may	may	MD
cord-296347-fanlvxqs	416	10	even	even	RB
cord-296347-fanlvxqs	416	11	be	be	VB
cord-296347-fanlvxqs	416	12	capable	capable	JJ
cord-296347-fanlvxqs	416	13	influencing	influence	VBG
cord-296347-fanlvxqs	416	14	substrate	substrate	NN
cord-296347-fanlvxqs	416	15	fate	fate	NN
cord-296347-fanlvxqs	416	16	(	(	-LRB-
cord-296347-fanlvxqs	416	17	Rumpf	Rumpf	NNP
cord-296347-fanlvxqs	416	18	and	and	CC
cord-296347-fanlvxqs	416	19	Jentsch	Jentsch	NNP
cord-296347-fanlvxqs	416	20	,	,	,
cord-296347-fanlvxqs	416	21	2006	2006	CD
cord-296347-fanlvxqs	416	22	)	)	-RRB-
cord-296347-fanlvxqs	416	23	.	.	.
cord-296347-fanlvxqs	417	1	Cdc48p	Cdc48p	NNP
cord-296347-fanlvxqs	417	2	/	/	SYM
cord-296347-fanlvxqs	417	3	p97	p97	CD
cord-296347-fanlvxqs	417	4	can	can	MD
cord-296347-fanlvxqs	417	5	simultaneously	simultaneously	RB
cord-296347-fanlvxqs	417	6	bind	bind	VB
cord-296347-fanlvxqs	417	7	Ufd2p	Ufd2p	NNP
cord-296347-fanlvxqs	417	8	,	,	,
cord-296347-fanlvxqs	417	9	a	a	DT
cord-296347-fanlvxqs	417	10	U	u	NN
cord-296347-fanlvxqs	417	11	-	-	HYPH
cord-296347-fanlvxqs	417	12	box	box	NN
cord-296347-fanlvxqs	417	13	E3	E3	NNP
cord-296347-fanlvxqs	417	14	that	that	WDT
cord-296347-fanlvxqs	417	15	catalyzes	catalyze	VBZ
cord-296347-fanlvxqs	417	16	polyubiquitin	polyubiquitin	NNP
cord-296347-fanlvxqs	417	17	chain	chain	NN
cord-296347-fanlvxqs	417	18	extension	extension	NN
cord-296347-fanlvxqs	417	19	,	,	,
cord-296347-fanlvxqs	417	20	and	and	CC
cord-296347-fanlvxqs	417	21	one	one	CD
cord-296347-fanlvxqs	417	22	of	of	IN
cord-296347-fanlvxqs	417	23	two	two	CD
cord-296347-fanlvxqs	417	24	factors	factor	NNS
cord-296347-fanlvxqs	417	25	that	that	WDT
cord-296347-fanlvxqs	417	26	can	can	MD
cord-296347-fanlvxqs	417	27	counteract	counteract	VB
cord-296347-fanlvxqs	417	28	its	-PRON-	PRP$
cord-296347-fanlvxqs	417	29	action	action	NN
cord-296347-fanlvxqs	417	30	:	:	:
cord-296347-fanlvxqs	417	31	Otu1p	otu1p	CC
cord-296347-fanlvxqs	417	32	,	,	,
cord-296347-fanlvxqs	417	33	a	a	DT
cord-296347-fanlvxqs	417	34	DUB	dub	NN
cord-296347-fanlvxqs	417	35	,	,	,
cord-296347-fanlvxqs	417	36	and	and	CC
cord-296347-fanlvxqs	417	37	Ufd3p	Ufd3p	NNP
cord-296347-fanlvxqs	417	38	protein	protein	NN
cord-296347-fanlvxqs	417	39	,	,	,
cord-296347-fanlvxqs	417	40	a	a	DT
cord-296347-fanlvxqs	417	41	WD40	WD40	NNP
cord-296347-fanlvxqs	417	42	repeat	repeat	NN
cord-296347-fanlvxqs	417	43	protein	protein	NN
cord-296347-fanlvxqs	417	44	of	of	IN
cord-296347-fanlvxqs	417	45	unknown	unknown	JJ
cord-296347-fanlvxqs	417	46	function	function	NN
cord-296347-fanlvxqs	417	47	that	that	WDT
cord-296347-fanlvxqs	417	48	has	have	VBZ
cord-296347-fanlvxqs	417	49	been	be	VBN
cord-296347-fanlvxqs	417	50	shown	show	VBN
cord-296347-fanlvxqs	417	51	to	to	TO
cord-296347-fanlvxqs	417	52	be	be	VB
cord-296347-fanlvxqs	417	53	required	require	VBN
cord-296347-fanlvxqs	417	54	for	for	IN
cord-296347-fanlvxqs	417	55	Ub	ub	JJ
cord-296347-fanlvxqs	417	56	-	-	HYPH
cord-296347-fanlvxqs	417	57	dependent	dependent	JJ
cord-296347-fanlvxqs	417	58	proteolysis	proteolysis	NN
cord-296347-fanlvxqs	417	59	(	(	-LRB-
cord-296347-fanlvxqs	417	60	Ghislain	Ghislain	NNP
cord-296347-fanlvxqs	417	61	et	et	NNP
cord-296347-fanlvxqs	417	62	al	al	NNP
cord-296347-fanlvxqs	417	63	.	.	NNP
cord-296347-fanlvxqs	417	64	,	,	,
cord-296347-fanlvxqs	417	65	1996	1996	CD
cord-296347-fanlvxqs	417	66	;	;	:
cord-296347-fanlvxqs	417	67	Johnson	Johnson	NNP
cord-296347-fanlvxqs	417	68	et	et	NNP
cord-296347-fanlvxqs	417	69	al	al	NNP
cord-296347-fanlvxqs	417	70	.	.	NNP
cord-296347-fanlvxqs	417	71	,	,	,
cord-296347-fanlvxqs	417	72	1995	1995	CD
cord-296347-fanlvxqs	417	73	)	)	-RRB-
cord-296347-fanlvxqs	417	74	.	.	.
cord-296347-fanlvxqs	418	1	Otu1p	Otu1p	NNP
cord-296347-fanlvxqs	418	2	can	can	MD
cord-296347-fanlvxqs	418	3	disassemble	disassemble	VB
cord-296347-fanlvxqs	418	4	the	the	DT
cord-296347-fanlvxqs	418	5	polyUb	polyub	NN
cord-296347-fanlvxqs	418	6	chains	chain	NNS
cord-296347-fanlvxqs	418	7	,	,	,
cord-296347-fanlvxqs	418	8	whereas	whereas	IN
cord-296347-fanlvxqs	418	9	Ufd3p	Ufd3p	NNP
cord-296347-fanlvxqs	418	10	competes	compete	VBZ
cord-296347-fanlvxqs	418	11	with	with	IN
cord-296347-fanlvxqs	418	12	Ufd2p	Ufd2p	NNP
cord-296347-fanlvxqs	418	13	for	for	IN
cord-296347-fanlvxqs	418	14	the	the	DT
cord-296347-fanlvxqs	418	15	same	same	JJ
cord-296347-fanlvxqs	418	16	docking	docking	NN
cord-296347-fanlvxqs	418	17	site	site	NN
cord-296347-fanlvxqs	418	18	on	on	IN
cord-296347-fanlvxqs	418	19	Cdc48p	Cdc48p	NNP
cord-296347-fanlvxqs	418	20	/	/	SYM
cord-296347-fanlvxqs	418	21	p97	p97	CD
cord-296347-fanlvxqs	418	22	.	.	.
cord-296347-fanlvxqs	419	1	Presumably	presumably	RB
cord-296347-fanlvxqs	419	2	,	,	,
cord-296347-fanlvxqs	419	3	Cdc48p	Cdc48p	NNP
cord-296347-fanlvxqs	419	4	/	/	SYM
cord-296347-fanlvxqs	419	5	p97	p97	CD
cord-296347-fanlvxqs	419	6	can	can	MD
cord-296347-fanlvxqs	419	7	selectively	selectively	RB
cord-296347-fanlvxqs	419	8	recruit	recruit	VB
cord-296347-fanlvxqs	419	9	different	different	JJ
cord-296347-fanlvxqs	419	10	substrate	substrate	NN
cord-296347-fanlvxqs	419	11	processing	processing	NN
cord-296347-fanlvxqs	419	12	cofactors	cofactor	NNS
cord-296347-fanlvxqs	419	13	and	and	CC
cord-296347-fanlvxqs	419	14	thus	thus	RB
cord-296347-fanlvxqs	419	15	tip	tip	VB
cord-296347-fanlvxqs	419	16	the	the	DT
cord-296347-fanlvxqs	419	17	balance	balance	NN
cord-296347-fanlvxqs	419	18	toward	toward	IN
cord-296347-fanlvxqs	419	19	substrate	substrate	JJ
cord-296347-fanlvxqs	419	20	degradation	degradation	NN
cord-296347-fanlvxqs	419	21	or	or	CC
cord-296347-fanlvxqs	419	22	release	release	NN
cord-296347-fanlvxqs	419	23	from	from	IN
cord-296347-fanlvxqs	419	24	the	the	DT
cord-296347-fanlvxqs	419	25	degradation	degradation	NN
cord-296347-fanlvxqs	419	26	cascade	cascade	NN
cord-296347-fanlvxqs	419	27	(	(	-LRB-
cord-296347-fanlvxqs	419	28	Rumpf	Rumpf	NNP
cord-296347-fanlvxqs	419	29	and	and	CC
cord-296347-fanlvxqs	419	30	Jentsch	Jentsch	NNP
cord-296347-fanlvxqs	419	31	,	,	,
cord-296347-fanlvxqs	419	32	2006	2006	CD
cord-296347-fanlvxqs	419	33	)	)	-RRB-
cord-296347-fanlvxqs	419	34	,	,	,
cord-296347-fanlvxqs	419	35	suggesting	suggest	VBG
cord-296347-fanlvxqs	419	36	a	a	DT
cord-296347-fanlvxqs	419	37	very	very	RB
cord-296347-fanlvxqs	419	38	tight	tight	JJ
cord-296347-fanlvxqs	419	39	regulation	regulation	NN
cord-296347-fanlvxqs	419	40	of	of	IN
cord-296347-fanlvxqs	419	41	proteasomal	proteasomal	JJ
cord-296347-fanlvxqs	419	42	proteolysis	proteolysis	NN
cord-296347-fanlvxqs	419	43	.	.	.
cord-296347-fanlvxqs	420	1	These	these	DT
cord-296347-fanlvxqs	420	2	aspects	aspect	NNS
cord-296347-fanlvxqs	420	3	are	be	VBP
cord-296347-fanlvxqs	420	4	important	important	JJ
cord-296347-fanlvxqs	420	5	not	not	RB
cord-296347-fanlvxqs	420	6	only	only	RB
cord-296347-fanlvxqs	420	7	to	to	TO
cord-296347-fanlvxqs	420	8	understand	understand	VB
cord-296347-fanlvxqs	420	9	how	how	WRB
cord-296347-fanlvxqs	420	10	these	these	DT
cord-296347-fanlvxqs	420	11	pathways	pathway	NNS
cord-296347-fanlvxqs	420	12	contribute	contribute	VBP
cord-296347-fanlvxqs	420	13	to	to	IN
cord-296347-fanlvxqs	420	14	class	class	NN
cord-296347-fanlvxqs	421	1	I	-PRON-	PRP
cord-296347-fanlvxqs	421	2	MHC	MHC	NNP
cord-296347-fanlvxqs	421	3	-	-	HYPH
cord-296347-fanlvxqs	421	4	peptide	peptide	NN
cord-296347-fanlvxqs	421	5	epitope	epitope	NN
cord-296347-fanlvxqs	421	6	presentation	presentation	NN
cord-296347-fanlvxqs	421	7	,	,	,
cord-296347-fanlvxqs	421	8	but	but	CC
cord-296347-fanlvxqs	421	9	also	also	RB
cord-296347-fanlvxqs	421	10	how	how	WRB
cord-296347-fanlvxqs	421	11	viruses	virus	NNS
cord-296347-fanlvxqs	421	12	manipulate	manipulate	VBP
cord-296347-fanlvxqs	421	13	these	these	DT
cord-296347-fanlvxqs	421	14	routes	route	NNS
cord-296347-fanlvxqs	421	15	to	to	TO
cord-296347-fanlvxqs	421	16	avoid	avoid	VB
cord-296347-fanlvxqs	421	17	detection	detection	NN
cord-296347-fanlvxqs	421	18	.	.	.
cord-296347-fanlvxqs	422	1	PNGase	PNGase	NNP
cord-296347-fanlvxqs	422	2	is	be	VBZ
cord-296347-fanlvxqs	422	3	a	a	DT
cord-296347-fanlvxqs	422	4	cytosolic	cytosolic	JJ
cord-296347-fanlvxqs	422	5	deglycosylating	deglycosylating	NN
cord-296347-fanlvxqs	422	6	enzyme	enzyme	NN
cord-296347-fanlvxqs	422	7	that	that	WDT
cord-296347-fanlvxqs	422	8	presumably	presumably	RB
cord-296347-fanlvxqs	422	9	removes	remove	VBZ
cord-296347-fanlvxqs	422	10	N	n	CD
cord-296347-fanlvxqs	422	11	-	-	HYPH
cord-296347-fanlvxqs	422	12	linked	link	VBN
cord-296347-fanlvxqs	422	13	glycan	glycan	NN
cord-296347-fanlvxqs	422	14	chains	chain	NNS
cord-296347-fanlvxqs	422	15	from	from	IN
cord-296347-fanlvxqs	422	16	misfolded	misfolded	JJ
cord-296347-fanlvxqs	422	17	substrates	substrate	NNS
cord-296347-fanlvxqs	422	18	prior	prior	RB
cord-296347-fanlvxqs	422	19	to	to	IN
cord-296347-fanlvxqs	422	20	proteasomal	proteasomal	JJ
cord-296347-fanlvxqs	422	21	degradation	degradation	NN
cord-296347-fanlvxqs	422	22	(	(	-LRB-
cord-296347-fanlvxqs	422	23	Hirsch	Hirsch	NNP
cord-296347-fanlvxqs	422	24	et	et	NNP
cord-296347-fanlvxqs	422	25	al	al	NNP
cord-296347-fanlvxqs	422	26	.	.	.
cord-296347-fanlvxqs	423	1	,	,	,
cord-296347-fanlvxqs	423	2	2003	2003	CD
cord-296347-fanlvxqs	423	3	;	;	:
cord-296347-fanlvxqs	423	4	Suzuki	Suzuki	NNP
cord-296347-fanlvxqs	423	5	et	et	NNP
cord-296347-fanlvxqs	423	6	al	al	NNP
cord-296347-fanlvxqs	423	7	.	.	NNP
cord-296347-fanlvxqs	423	8	,	,	,
cord-296347-fanlvxqs	423	9	2000	2000	CD
cord-296347-fanlvxqs	423	10	)	)	-RRB-
cord-296347-fanlvxqs	423	11	.	.	.
cord-296347-fanlvxqs	424	1	Both	both	DT
cord-296347-fanlvxqs	424	2	in	in	IN
cord-296347-fanlvxqs	424	3	yeast	yeast	NN
cord-296347-fanlvxqs	424	4	and	and	CC
cord-296347-fanlvxqs	424	5	mammals	mammal	NNS
cord-296347-fanlvxqs	424	6	,	,	,
cord-296347-fanlvxqs	424	7	there	there	EX
cord-296347-fanlvxqs	424	8	is	be	VBZ
cord-296347-fanlvxqs	424	9	generally	generally	RB
cord-296347-fanlvxqs	424	10	a	a	DT
cord-296347-fanlvxqs	424	11	tightly	tightly	RB
cord-296347-fanlvxqs	424	12	knit	knit	VBN
cord-296347-fanlvxqs	424	13	relationship	relationship	NN
cord-296347-fanlvxqs	424	14	between	between	IN
cord-296347-fanlvxqs	424	15	PNGase	PNGase	NNP
cord-296347-fanlvxqs	424	16	and	and	CC
cord-296347-fanlvxqs	424	17	the	the	DT
cord-296347-fanlvxqs	424	18	proteasome	proteasome	NN
cord-296347-fanlvxqs	424	19	:	:	:
cord-296347-fanlvxqs	425	1	PNGase	PNGase	NNP
cord-296347-fanlvxqs	425	2	interacts	interact	VBZ
cord-296347-fanlvxqs	425	3	with	with	IN
cord-296347-fanlvxqs	425	4	(	(	-LRB-
cord-296347-fanlvxqs	425	5	at	at	IN
cord-296347-fanlvxqs	425	6	least	least	JJS
cord-296347-fanlvxqs	425	7	)	)	-RRB-
cord-296347-fanlvxqs	425	8	the	the	DT
cord-296347-fanlvxqs	425	9	S4	S4	NNP
cord-296347-fanlvxqs	425	10	and	and	CC
cord-296347-fanlvxqs	425	11	S5	S5	NNP
cord-296347-fanlvxqs	425	12	subunits	subunit	NNS
cord-296347-fanlvxqs	425	13	of	of	IN
cord-296347-fanlvxqs	425	14	the	the	DT
cord-296347-fanlvxqs	425	15	mammalian	mammalian	JJ
cord-296347-fanlvxqs	425	16	19S	19s	CD
cord-296347-fanlvxqs	425	17	proteasome	proteasome	NN
cord-296347-fanlvxqs	425	18	and	and	CC
cord-296347-fanlvxqs	425	19	the	the	DT
cord-296347-fanlvxqs	425	20	Ub	Ub	NNP
cord-296347-fanlvxqs	425	21	-	-	HYPH
cord-296347-fanlvxqs	425	22	binding	binding	NN
cord-296347-fanlvxqs	425	23	factor	factor	NN
cord-296347-fanlvxqs	425	24	Rad23p	Rad23p	NNP
cord-296347-fanlvxqs	426	1	(	(	-LRB-
cord-296347-fanlvxqs	426	2	HR23B	hr23b	NN
cord-296347-fanlvxqs	426	3	in	in	IN
cord-296347-fanlvxqs	426	4	mammals	mammal	NNS
cord-296347-fanlvxqs	426	5	)	)	-RRB-
cord-296347-fanlvxqs	426	6	,	,	,
cord-296347-fanlvxqs	426	7	which	which	WDT
cord-296347-fanlvxqs	426	8	seems	seem	VBZ
cord-296347-fanlvxqs	426	9	to	to	TO
cord-296347-fanlvxqs	426	10	recognize	recognize	VB
cord-296347-fanlvxqs	426	11	only	only	RB
cord-296347-fanlvxqs	426	12	deglycosylated	deglycosylated	JJ
cord-296347-fanlvxqs	426	13	degradation	degradation	NN
cord-296347-fanlvxqs	426	14	substrates	substrate	NNS
cord-296347-fanlvxqs	426	15	(	(	-LRB-
cord-296347-fanlvxqs	426	16	Katiyar	Katiyar	NNP
cord-296347-fanlvxqs	426	17	et	et	FW
cord-296347-fanlvxqs	426	18	al	al	NNP
cord-296347-fanlvxqs	426	19	.	.	NNP
cord-296347-fanlvxqs	426	20	,	,	,
cord-296347-fanlvxqs	426	21	2004	2004	CD
cord-296347-fanlvxqs	426	22	)	)	-RRB-
cord-296347-fanlvxqs	426	23	.	.	.
cord-296347-fanlvxqs	427	1	This	this	DT
cord-296347-fanlvxqs	427	2	suggests	suggest	VBZ
cord-296347-fanlvxqs	427	3	that	that	IN
cord-296347-fanlvxqs	427	4	misfolded	misfolde	VBN
cord-296347-fanlvxqs	427	5	protein	protein	NN
cord-296347-fanlvxqs	427	6	substrates	substrate	NNS
cord-296347-fanlvxqs	427	7	may	may	MD
cord-296347-fanlvxqs	427	8	first	first	RB
cord-296347-fanlvxqs	427	9	be	be	VB
cord-296347-fanlvxqs	427	10	deglycosylated	deglycosylate	VBN
cord-296347-fanlvxqs	427	11	by	by	IN
cord-296347-fanlvxqs	427	12	ER	ER	NNP
cord-296347-fanlvxqs	427	13	-	-	HYPH
cord-296347-fanlvxqs	427	14	associated	associate	VBN
cord-296347-fanlvxqs	427	15	or	or	CC
cord-296347-fanlvxqs	427	16	free	free	JJ
cord-296347-fanlvxqs	427	17	PNGase	PNGase	NNP
cord-296347-fanlvxqs	427	18	,	,	,
cord-296347-fanlvxqs	427	19	then	then	RB
cord-296347-fanlvxqs	427	20	identified	identify	VBN
cord-296347-fanlvxqs	427	21	by	by	IN
cord-296347-fanlvxqs	427	22	the	the	DT
cord-296347-fanlvxqs	427	23	HR23B	hr23b	NN
cord-296347-fanlvxqs	427	24	adaptor	adaptor	NN
cord-296347-fanlvxqs	427	25	protein	protein	NN
cord-296347-fanlvxqs	427	26	,	,	,
cord-296347-fanlvxqs	427	27	and	and	CC
cord-296347-fanlvxqs	427	28	subsequently	subsequently	RB
cord-296347-fanlvxqs	427	29	targeted	target	VBN
cord-296347-fanlvxqs	427	30	to	to	IN
cord-296347-fanlvxqs	427	31	the	the	DT
cord-296347-fanlvxqs	427	32	nearby	nearby	JJ
cord-296347-fanlvxqs	427	33	proteasome	proteasome	NN
cord-296347-fanlvxqs	427	34	(	(	-LRB-
cord-296347-fanlvxqs	427	35	Katiyar	Katiyar	NNP
cord-296347-fanlvxqs	427	36	et	et	FW
cord-296347-fanlvxqs	427	37	al	al	NNP
cord-296347-fanlvxqs	427	38	.	.	NNP
cord-296347-fanlvxqs	427	39	,	,	,
cord-296347-fanlvxqs	427	40	2004	2004	CD
cord-296347-fanlvxqs	427	41	)	)	-RRB-
cord-296347-fanlvxqs	427	42	.	.	.
cord-296347-fanlvxqs	428	1	Mammalian	mammalian	JJ
cord-296347-fanlvxqs	428	2	PNGase	PNGase	NNP
cord-296347-fanlvxqs	428	3	also	also	RB
cord-296347-fanlvxqs	428	4	associates	associate	VBZ
cord-296347-fanlvxqs	428	5	with	with	IN
cord-296347-fanlvxqs	428	6	the	the	DT
cord-296347-fanlvxqs	428	7	ER	ER	NNP
cord-296347-fanlvxqs	428	8	membrane	membrane	NN
cord-296347-fanlvxqs	428	9	gp78	gp78	NN
cord-296347-fanlvxqs	428	10	E3	E3	NNP
cord-296347-fanlvxqs	428	11	ligase	ligase	NN
cord-296347-fanlvxqs	428	12	and	and	CC
cord-296347-fanlvxqs	428	13	the	the	DT
cord-296347-fanlvxqs	428	14	cytosolic	cytosolic	JJ
cord-296347-fanlvxqs	428	15	p97	p97	NN
cord-296347-fanlvxqs	428	16	and	and	CC
cord-296347-fanlvxqs	428	17	Y33	Y33	NNP
cord-296347-fanlvxqs	428	18	K	K	NNP
cord-296347-fanlvxqs	428	19	,	,	,
cord-296347-fanlvxqs	428	20	a	a	DT
cord-296347-fanlvxqs	428	21	UBA	UBA	NNP
cord-296347-fanlvxqs	428	22	/	/	SYM
cord-296347-fanlvxqs	428	23	UBX	UBX	NNP
cord-296347-fanlvxqs	428	24	domain	domain	NN
cord-296347-fanlvxqs	428	25	protein	protein	NN
cord-296347-fanlvxqs	428	26	(	(	-LRB-
cord-296347-fanlvxqs	428	27	Li	Li	NNP
cord-296347-fanlvxqs	428	28	et	et	NNP
cord-296347-fanlvxqs	428	29	al	al	NNP
cord-296347-fanlvxqs	428	30	.	.	NNP
cord-296347-fanlvxqs	428	31	,	,	,
cord-296347-fanlvxqs	428	32	2006a	2006a	CD
cord-296347-fanlvxqs	428	33	)	)	-RRB-
cord-296347-fanlvxqs	428	34	.	.	.
cord-296347-fanlvxqs	429	1	A	a	DT
cord-296347-fanlvxqs	429	2	gp78-Y33K	gp78-y33k	XX
cord-296347-fanlvxqs	429	3	-	-	HYPH
cord-296347-fanlvxqs	429	4	p97-PNGase	p97-pngase	NN
cord-296347-fanlvxqs	429	5	-	-	HYPH
cord-296347-fanlvxqs	429	6	HR23B	hr23b	NN
cord-296347-fanlvxqs	429	7	complex	complex	NN
cord-296347-fanlvxqs	429	8	could	could	MD
cord-296347-fanlvxqs	429	9	therefore	therefore	RB
cord-296347-fanlvxqs	429	10	be	be	VB
cord-296347-fanlvxqs	429	11	formed	form	VBN
cord-296347-fanlvxqs	429	12	that	that	IN
cord-296347-fanlvxqs	429	13	recruits	recruit	VBZ
cord-296347-fanlvxqs	429	14	PNGase	PNGase	NNP
cord-296347-fanlvxqs	429	15	to	to	IN
cord-296347-fanlvxqs	429	16	the	the	DT
cord-296347-fanlvxqs	429	17	cytosolic	cytosolic	JJ
cord-296347-fanlvxqs	429	18	face	face	NN
cord-296347-fanlvxqs	429	19	of	of	IN
cord-296347-fanlvxqs	429	20	the	the	DT
cord-296347-fanlvxqs	429	21	ER	ER	NNP
cord-296347-fanlvxqs	429	22	membrane	membrane	NN
cord-296347-fanlvxqs	429	23	that	that	WDT
cord-296347-fanlvxqs	429	24	couples	couple	VBZ
cord-296347-fanlvxqs	429	25	the	the	DT
cord-296347-fanlvxqs	429	26	activities	activity	NNS
cord-296347-fanlvxqs	429	27	of	of	IN
cord-296347-fanlvxqs	429	28	dislocation	dislocation	NN
cord-296347-fanlvxqs	429	29	,	,	,
cord-296347-fanlvxqs	429	30	ubiquitination	ubiquitination	NN
cord-296347-fanlvxqs	429	31	,	,	,
cord-296347-fanlvxqs	429	32	and	and	CC
cord-296347-fanlvxqs	429	33	deglycosylation	deglycosylation	NN
cord-296347-fanlvxqs	429	34	and	and	CC
cord-296347-fanlvxqs	429	35	escorts	escort	NNS
cord-296347-fanlvxqs	429	36	misfolded	misfolde	VBD
cord-296347-fanlvxqs	429	37	glycoproteins	glycoprotein	NNS
cord-296347-fanlvxqs	429	38	to	to	IN
cord-296347-fanlvxqs	429	39	the	the	DT
cord-296347-fanlvxqs	429	40	proteasome	proteasome	NN
cord-296347-fanlvxqs	429	41	(	(	-LRB-
cord-296347-fanlvxqs	429	42	Kim	Kim	NNP
cord-296347-fanlvxqs	429	43	et	et	NNP
cord-296347-fanlvxqs	429	44	al	al	NNP
cord-296347-fanlvxqs	429	45	.	.	NNP
cord-296347-fanlvxqs	429	46	,	,	,
cord-296347-fanlvxqs	429	47	2006a	2006a	CD
cord-296347-fanlvxqs	429	48	;	;	:
cord-296347-fanlvxqs	429	49	Li	Li	NNP
cord-296347-fanlvxqs	429	50	et	et	NNP
cord-296347-fanlvxqs	429	51	al	al	NNP
cord-296347-fanlvxqs	429	52	.	.	.
cord-296347-fanlvxqs	430	1	,	,	,
cord-296347-fanlvxqs	430	2	,	,	,
cord-296347-fanlvxqs	430	3	2006a	2006a	CD
cord-296347-fanlvxqs	430	4	.	.	.
cord-296347-fanlvxqs	431	1	Viruses	virus	NNS
cord-296347-fanlvxqs	431	2	keep	keep	VBP
cord-296347-fanlvxqs	431	3	evolving	evolve	VBG
cord-296347-fanlvxqs	431	4	and	and	CC
cord-296347-fanlvxqs	431	5	developing	develop	VBG
cord-296347-fanlvxqs	431	6	sophisticated	sophisticated	JJ
cord-296347-fanlvxqs	431	7	immune	immune	JJ
cord-296347-fanlvxqs	431	8	evasion	evasion	NN
cord-296347-fanlvxqs	431	9	strategies	strategy	NNS
cord-296347-fanlvxqs	431	10	.	.	.
cord-296347-fanlvxqs	432	1	In	in	IN
cord-296347-fanlvxqs	432	2	particular	particular	JJ
cord-296347-fanlvxqs	432	3	,	,	,
cord-296347-fanlvxqs	432	4	they	-PRON-	PRP
cord-296347-fanlvxqs	432	5	have	have	VBP
cord-296347-fanlvxqs	432	6	targeted	target	VBN
cord-296347-fanlvxqs	432	7	virtually	virtually	RB
cord-296347-fanlvxqs	432	8	every	every	DT
cord-296347-fanlvxqs	432	9	step	step	NN
cord-296347-fanlvxqs	432	10	of	of	IN
cord-296347-fanlvxqs	432	11	the	the	DT
cord-296347-fanlvxqs	432	12	class	class	NN
cord-296347-fanlvxqs	433	1	I	-PRON-	PRP
cord-296347-fanlvxqs	433	2	MHC	MHC	NNP
cord-296347-fanlvxqs	433	3	antigen	antigen	NN
cord-296347-fanlvxqs	433	4	presentation	presentation	NN
cord-296347-fanlvxqs	433	5	pathway	pathway	NN
cord-296347-fanlvxqs	433	6	,	,	,
cord-296347-fanlvxqs	433	7	inhibiting	inhibit	VBG
cord-296347-fanlvxqs	433	8	proteolysis	proteolysis	NN
cord-296347-fanlvxqs	433	9	and	and	CC
cord-296347-fanlvxqs	433	10	generation	generation	NN
cord-296347-fanlvxqs	433	11	of	of	IN
cord-296347-fanlvxqs	433	12	the	the	DT
cord-296347-fanlvxqs	433	13	antigenic	antigenic	JJ
cord-296347-fanlvxqs	433	14	peptide	peptide	NN
cord-296347-fanlvxqs	433	15	[	[	-LRB-
cord-296347-fanlvxqs	433	16	Epstein	Epstein	NNP
cord-296347-fanlvxqs	433	17	-	-	HYPH
cord-296347-fanlvxqs	433	18	Barr	Barr	NNP
cord-296347-fanlvxqs	433	19	virus	virus	NN
cord-296347-fanlvxqs	433	20	(	(	-LRB-
cord-296347-fanlvxqs	433	21	EBV	EBV	NNP
cord-296347-fanlvxqs	433	22	)	)	-RRB-
cord-296347-fanlvxqs	433	23	nuclear	nuclear	JJ
cord-296347-fanlvxqs	433	24	antigen-1	antigen-1	NNP
cord-296347-fanlvxqs	433	25	or	or	CC
cord-296347-fanlvxqs	433	26	EBNA-1	EBNA-1	NNP
cord-296347-fanlvxqs	433	27	,	,	,
cord-296347-fanlvxqs	433	28	HCMV	HCMV	NNP
cord-296347-fanlvxqs	433	29	E	E	NNP
cord-296347-fanlvxqs	433	30	protein	protein	NN
cord-296347-fanlvxqs	433	31	pp65	pp65	RB
cord-296347-fanlvxqs	433	32	,	,	,
cord-296347-fanlvxqs	433	33	and	and	CC
cord-296347-fanlvxqs	433	34	HIV	HIV	NNP
cord-296347-fanlvxqs	433	35	Tat	Tat	NNP
cord-296347-fanlvxqs	433	36	]	]	-RRB-
cord-296347-fanlvxqs	433	37	,	,	,
cord-296347-fanlvxqs	433	38	inhibiting	inhibit	VBG
cord-296347-fanlvxqs	433	39	peptide	peptide	NN
cord-296347-fanlvxqs	433	40	loading	loading	NN
cord-296347-fanlvxqs	433	41	and	and	CC
cord-296347-fanlvxqs	433	42	assembly	assembly	NN
cord-296347-fanlvxqs	433	43	in	in	IN
cord-296347-fanlvxqs	433	44	the	the	DT
cord-296347-fanlvxqs	433	45	ER	ER	NNP
cord-296347-fanlvxqs	433	46	(	(	-LRB-
cord-296347-fanlvxqs	433	47	HSV	HSV	NNP
cord-296347-fanlvxqs	433	48	ICP47	ICP47	NNP
cord-296347-fanlvxqs	433	49	,	,	,
cord-296347-fanlvxqs	433	50	HCMV	HCMV	NNP
cord-296347-fanlvxqs	433	51	US6	US6	NNP
cord-296347-fanlvxqs	433	52	,	,	,
cord-296347-fanlvxqs	433	53	bovine	bovine	JJ
cord-296347-fanlvxqs	433	54	herpes	herpes	NN
cord-296347-fanlvxqs	433	55	-	-	HYPH
cord-296347-fanlvxqs	433	56	virus-1	virus-1	NN
cord-296347-fanlvxqs	433	57	UL49.5	ul49.5	NN
cord-296347-fanlvxqs	433	58	)	)	-RRB-
cord-296347-fanlvxqs	433	59	,	,	,
cord-296347-fanlvxqs	433	60	retaining	retain	VBG
cord-296347-fanlvxqs	433	61	class	class	NN
cord-296347-fanlvxqs	433	62	I	-PRON-	PRP
cord-296347-fanlvxqs	433	63	MHC	MHC	NNP
cord-296347-fanlvxqs	433	64	molecules	molecule	NNS
cord-296347-fanlvxqs	433	65	in	in	IN
cord-296347-fanlvxqs	433	66	the	the	DT
cord-296347-fanlvxqs	433	67	ER	ER	NNP
cord-296347-fanlvxqs	433	68	(	(	-LRB-
cord-296347-fanlvxqs	433	69	adenovirus	adenovirus	NN
cord-296347-fanlvxqs	433	70	E3/19	e3/19	NN
cord-296347-fanlvxqs	433	71	K	K	NNP
cord-296347-fanlvxqs	433	72	and	and	CC
cord-296347-fanlvxqs	433	73	HCMV	HCMV	NNP
cord-296347-fanlvxqs	433	74	US3	US3	NNP
cord-296347-fanlvxqs	433	75	)	)	-RRB-
cord-296347-fanlvxqs	433	76	,	,	,
cord-296347-fanlvxqs	433	77	blocking	block	VBG
cord-296347-fanlvxqs	433	78	their	-PRON-	PRP$
cord-296347-fanlvxqs	433	79	exit	exit	NN
cord-296347-fanlvxqs	433	80	from	from	IN
cord-296347-fanlvxqs	433	81	the	the	DT
cord-296347-fanlvxqs	433	82	ER	ER	NNP
cord-296347-fanlvxqs	433	83	-	-	HYPH
cord-296347-fanlvxqs	433	84	to	to	IN
cord-296347-fanlvxqs	433	85	-	-	HYPH
cord-296347-fanlvxqs	433	86	Golgi	golgi	NN
cord-296347-fanlvxqs	433	87	complex	complex	NN
cord-296347-fanlvxqs	433	88	(	(	-LRB-
cord-296347-fanlvxqs	433	89	ERGIC	ergic	NN
cord-296347-fanlvxqs	433	90	)	)	-RRB-
cord-296347-fanlvxqs	434	1	(	(	-LRB-
cord-296347-fanlvxqs	434	2	MCMV	MCMV	NNP
cord-296347-fanlvxqs	434	3	m152	m152	NNP
cord-296347-fanlvxqs	434	4	)	)	-RRB-
cord-296347-fanlvxqs	434	5	,	,	,
cord-296347-fanlvxqs	434	6	misdirecting	misdirect	VBG
cord-296347-fanlvxqs	434	7	MHC	MHC	NNP
cord-296347-fanlvxqs	434	8	complexes	complex	NNS
cord-296347-fanlvxqs	434	9	to	to	IN
cord-296347-fanlvxqs	434	10	lysosomal	lysosomal	JJ
cord-296347-fanlvxqs	434	11	compartments	compartment	NNS
cord-296347-fanlvxqs	434	12	(	(	-LRB-
cord-296347-fanlvxqs	434	13	MCMV	MCMV	NNP
cord-296347-fanlvxqs	434	14	m06	m06	,
cord-296347-fanlvxqs	434	15	and	and	CC
cord-296347-fanlvxqs	434	16	HHV-7	HHV-7	NNP
cord-296347-fanlvxqs	434	17	U21	U21	NNP
cord-296347-fanlvxqs	434	18	)	)	-RRB-
cord-296347-fanlvxqs	434	19	,	,	,
cord-296347-fanlvxqs	434	20	internalizing	internalize	VBG
cord-296347-fanlvxqs	434	21	MHC	MHC	NNP
cord-296347-fanlvxqs	434	22	complexes	complex	NNS
cord-296347-fanlvxqs	434	23	from	from	IN
cord-296347-fanlvxqs	434	24	the	the	DT
cord-296347-fanlvxqs	434	25	cell	cell	NN
cord-296347-fanlvxqs	434	26	surface	surface	NN
cord-296347-fanlvxqs	434	27	(	(	-LRB-
cord-296347-fanlvxqs	434	28	KSHV	KSHV	NNP
cord-296347-fanlvxqs	434	29	K3	K3	NNP
cord-296347-fanlvxqs	434	30	and	and	CC
cord-296347-fanlvxqs	434	31	K5	K5	NNP
cord-296347-fanlvxqs	434	32	and	and	CC
cord-296347-fanlvxqs	434	33	HIV	HIV	NNP
cord-296347-fanlvxqs	434	34	Nef	Nef	NNP
cord-296347-fanlvxqs	434	35	)	)	-RRB-
cord-296347-fanlvxqs	434	36	,	,	,
cord-296347-fanlvxqs	434	37	encoding	encode	VBG
cord-296347-fanlvxqs	434	38	homologues	homologue	NNS
cord-296347-fanlvxqs	434	39	of	of	IN
cord-296347-fanlvxqs	434	40	class	class	NN
cord-296347-fanlvxqs	434	41	I	-PRON-	PRP
cord-296347-fanlvxqs	434	42	MHC	MHC	NNP
cord-296347-fanlvxqs	434	43	as	as	IN
cord-296347-fanlvxqs	434	44	decoys	decoy	NNS
cord-296347-fanlvxqs	434	45	for	for	IN
cord-296347-fanlvxqs	434	46	NK	NK	NNP
cord-296347-fanlvxqs	434	47	cells	cell	NNS
cord-296347-fanlvxqs	435	1	(	(	-LRB-
cord-296347-fanlvxqs	435	2	HCMV	HCMV	NNP
cord-296347-fanlvxqs	435	3	UL18	UL18	NNP
cord-296347-fanlvxqs	435	4	and	and	CC
cord-296347-fanlvxqs	435	5	UL142	ul142	NN
cord-296347-fanlvxqs	435	6	and	and	CC
cord-296347-fanlvxqs	435	7	MCMV	MCMV	NNP
cord-296347-fanlvxqs	435	8	m04	m04	NN
cord-296347-fanlvxqs	435	9	)	)	-RRB-
cord-296347-fanlvxqs	435	10	,	,	,
cord-296347-fanlvxqs	435	11	and	and	CC
cord-296347-fanlvxqs	435	12	causing	cause	VBG
cord-296347-fanlvxqs	435	13	degradation	degradation	NN
cord-296347-fanlvxqs	435	14	of	of	IN
cord-296347-fanlvxqs	435	15	class	class	NN
cord-296347-fanlvxqs	435	16	I	-PRON-	PRP
cord-296347-fanlvxqs	435	17	MHC	MHC	NNP
cord-296347-fanlvxqs	435	18	products	product	NNS
cord-296347-fanlvxqs	435	19	by	by	IN
cord-296347-fanlvxqs	435	20	the	the	DT
cord-296347-fanlvxqs	435	21	Ub	Ub	NNP
cord-296347-fanlvxqs	435	22	-	-	HYPH
cord-296347-fanlvxqs	435	23	proteasome	proteasome	NN
cord-296347-fanlvxqs	435	24	system	system	NN
cord-296347-fanlvxqs	435	25	(	(	-LRB-
cord-296347-fanlvxqs	435	26	HCMV	HCMV	NNP
cord-296347-fanlvxqs	435	27	US2	US2	NNP
cord-296347-fanlvxqs	435	28	and	and	CC
cord-296347-fanlvxqs	435	29	US11	US11	NNP
cord-296347-fanlvxqs	435	30	and	and	CC
cord-296347-fanlvxqs	435	31	MHV-68	MHV-68	NNP
cord-296347-fanlvxqs	435	32	mK3	mK3	NNP
cord-296347-fanlvxqs	435	33	)	)	-RRB-
cord-296347-fanlvxqs	436	1	(	(	-LRB-
cord-296347-fanlvxqs	436	2	Fig	Fig	NNP
cord-296347-fanlvxqs	436	3	.	.	.
cord-296347-fanlvxqs	437	1	5	5	LS
cord-296347-fanlvxqs	437	2	)	)	-RRB-
cord-296347-fanlvxqs	437	3	.	.	.
cord-296347-fanlvxqs	438	1	Because	because	IN
cord-296347-fanlvxqs	438	2	these	these	DT
cord-296347-fanlvxqs	438	3	topics	topic	NNS
cord-296347-fanlvxqs	438	4	have	have	VBP
cord-296347-fanlvxqs	438	5	been	be	VBN
cord-296347-fanlvxqs	438	6	the	the	DT
cord-296347-fanlvxqs	438	7	subject	subject	NN
cord-296347-fanlvxqs	438	8	of	of	IN
cord-296347-fanlvxqs	438	9	numerous	numerous	JJ
cord-296347-fanlvxqs	438	10	reviews	review	NNS
cord-296347-fanlvxqs	438	11	(	(	-LRB-
cord-296347-fanlvxqs	438	12	Alcami	Alcami	NNP
cord-296347-fanlvxqs	438	13	and	and	CC
cord-296347-fanlvxqs	438	14	Koszinowski	Koszinowski	NNP
cord-296347-fanlvxqs	438	15	,	,	,
cord-296347-fanlvxqs	438	16	2000	2000	CD
cord-296347-fanlvxqs	438	17	;	;	:
cord-296347-fanlvxqs	438	18	Ambagala	Ambagala	NNP
cord-296347-fanlvxqs	438	19	et	et	NNP
cord-296347-fanlvxqs	438	20	al	al	NNP
cord-296347-fanlvxqs	438	21	.	.	.
cord-296347-fanlvxqs	439	1	,	,	,
cord-296347-fanlvxqs	439	2	2005	2005	CD
cord-296347-fanlvxqs	439	3	;	;	:
cord-296347-fanlvxqs	439	4	Hengel	Hengel	NNP
cord-296347-fanlvxqs	439	5	et	et	NNP
cord-296347-fanlvxqs	439	6	al	al	NNP
cord-296347-fanlvxqs	439	7	.	.	.
cord-296347-fanlvxqs	440	1	,	,	,
cord-296347-fanlvxqs	440	2	1998	1998	CD
cord-296347-fanlvxqs	440	3	Hengel	Hengel	NNP
cord-296347-fanlvxqs	440	4	et	et	NNP
cord-296347-fanlvxqs	440	5	al	al	NNP
cord-296347-fanlvxqs	440	6	.	.	.
cord-296347-fanlvxqs	441	1	,	,	,
cord-296347-fanlvxqs	441	2	,	,	,
cord-296347-fanlvxqs	441	3	1999	1999	CD
cord-296347-fanlvxqs	441	4	Lybarger	Lybarger	NNP
cord-296347-fanlvxqs	441	5	et	et	NNP
cord-296347-fanlvxqs	441	6	al	al	NNP
cord-296347-fanlvxqs	441	7	.	.	NNP
cord-296347-fanlvxqs	441	8	,	,	,
cord-296347-fanlvxqs	441	9	2003	2003	CD
cord-296347-fanlvxqs	442	1	;	;	:
cord-296347-fanlvxqs	442	2	Mocarski	Mocarski	NNP
cord-296347-fanlvxqs	442	3	,	,	,
cord-296347-fanlvxqs	442	4	2004	2004	CD
cord-296347-fanlvxqs	442	5	;	;	:
cord-296347-fanlvxqs	442	6	Yewdell	Yewdell	NNP
cord-296347-fanlvxqs	442	7	and	and	CC
cord-296347-fanlvxqs	442	8	Hill	Hill	NNP
cord-296347-fanlvxqs	442	9	,	,	,
cord-296347-fanlvxqs	442	10	2002	2002	CD
cord-296347-fanlvxqs	442	11	)	)	-RRB-
cord-296347-fanlvxqs	443	1	,	,	,
cord-296347-fanlvxqs	443	2	we	-PRON-	PRP
cord-296347-fanlvxqs	443	3	shall	shall	MD
cord-296347-fanlvxqs	443	4	discuss	discuss	VB
cord-296347-fanlvxqs	443	5	only	only	RB
cord-296347-fanlvxqs	443	6	a	a	DT
cord-296347-fanlvxqs	443	7	few	few	JJ
cord-296347-fanlvxqs	443	8	of	of	IN
cord-296347-fanlvxqs	443	9	these	these	DT
cord-296347-fanlvxqs	443	10	mechanisms	mechanism	NNS
cord-296347-fanlvxqs	443	11	in	in	IN
cord-296347-fanlvxqs	443	12	more	more	JJR
cord-296347-fanlvxqs	443	13	detail	detail	NN
cord-296347-fanlvxqs	443	14	,	,	,
cord-296347-fanlvxqs	443	15	particularly	particularly	RB
cord-296347-fanlvxqs	443	16	those	those	DT
cord-296347-fanlvxqs	443	17	exploited	exploit	VBN
cord-296347-fanlvxqs	443	18	by	by	IN
cord-296347-fanlvxqs	443	19	HCMV	HCMV	NNP
cord-296347-fanlvxqs	443	20	.	.	.
cord-296347-fanlvxqs	444	1	The	the	DT
cord-296347-fanlvxqs	444	2	b	b	NN
cord-296347-fanlvxqs	444	3	-	-	HYPH
cord-296347-fanlvxqs	444	4	herpesvirus	herpesvirus	NN
cord-296347-fanlvxqs	444	5	HCMV	HCMV	NNP
cord-296347-fanlvxqs	444	6	is	be	VBZ
cord-296347-fanlvxqs	444	7	extremely	extremely	RB
cord-296347-fanlvxqs	444	8	successful	successful	JJ
cord-296347-fanlvxqs	444	9	in	in	IN
cord-296347-fanlvxqs	444	10	evolutionary	evolutionary	JJ
cord-296347-fanlvxqs	444	11	terms	term	NNS
cord-296347-fanlvxqs	444	12	:	:	:
cord-296347-fanlvxqs	444	13	it	-PRON-	PRP
cord-296347-fanlvxqs	444	14	is	be	VBZ
cord-296347-fanlvxqs	444	15	a	a	DT
cord-296347-fanlvxqs	444	16	ubiquitous	ubiquitous	JJ
cord-296347-fanlvxqs	444	17	,	,	,
cord-296347-fanlvxqs	444	18	highly	highly	RB
cord-296347-fanlvxqs	444	19	species	species	NN
cord-296347-fanlvxqs	444	20	-	-	HYPH
cord-296347-fanlvxqs	444	21	adapted	adapt	VBN
cord-296347-fanlvxqs	444	22	pathogen	pathogen	NN
cord-296347-fanlvxqs	444	23	that	that	WDT
cord-296347-fanlvxqs	444	24	is	be	VBZ
cord-296347-fanlvxqs	444	25	able	able	JJ
cord-296347-fanlvxqs	444	26	to	to	TO
cord-296347-fanlvxqs	444	27	establish	establish	VB
cord-296347-fanlvxqs	444	28	a	a	DT
cord-296347-fanlvxqs	444	29	life	life	NN
cord-296347-fanlvxqs	444	30	-	-	HYPH
cord-296347-fanlvxqs	444	31	long	long	JJ
cord-296347-fanlvxqs	444	32	persistent	persistent	JJ
cord-296347-fanlvxqs	444	33	infection	infection	NN
cord-296347-fanlvxqs	444	34	with	with	IN
cord-296347-fanlvxqs	444	35	minimal	minimal	JJ
cord-296347-fanlvxqs	444	36	or	or	CC
cord-296347-fanlvxqs	444	37	no	no	DT
cord-296347-fanlvxqs	444	38	disease	disease	NN
cord-296347-fanlvxqs	444	39	symptoms	symptom	NNS
cord-296347-fanlvxqs	444	40	in	in	IN
cord-296347-fanlvxqs	444	41	the	the	DT
cord-296347-fanlvxqs	444	42	immunocompetent	immunocompetent	JJ
cord-296347-fanlvxqs	444	43	host	host	NN
cord-296347-fanlvxqs	444	44	.	.	.
cord-296347-fanlvxqs	445	1	Prolonged	prolonged	JJ
cord-296347-fanlvxqs	445	2	latency	latency	NN
cord-296347-fanlvxqs	445	3	periods	period	NNS
cord-296347-fanlvxqs	445	4	(	(	-LRB-
cord-296347-fanlvxqs	445	5	a	a	DT
cord-296347-fanlvxqs	445	6	dormant	dormant	JJ
cord-296347-fanlvxqs	445	7	state	state	NN
cord-296347-fanlvxqs	445	8	with	with	IN
cord-296347-fanlvxqs	445	9	minimal	minimal	JJ
cord-296347-fanlvxqs	445	10	production	production	NN
cord-296347-fanlvxqs	445	11	of	of	IN
cord-296347-fanlvxqs	445	12	viral	viral	JJ
cord-296347-fanlvxqs	445	13	proteins	protein	NNS
cord-296347-fanlvxqs	445	14	and	and	CC
cord-296347-fanlvxqs	445	15	absence	absence	NN
cord-296347-fanlvxqs	445	16	of	of	IN
cord-296347-fanlvxqs	445	17	viral	viral	JJ
cord-296347-fanlvxqs	445	18	progeny	progeny	NN
cord-296347-fanlvxqs	445	19	)	)	-RRB-
cord-296347-fanlvxqs	445	20	and	and	CC
cord-296347-fanlvxqs	445	21	controlled	control	VBN
cord-296347-fanlvxqs	445	22	sporadic	sporadic	JJ
cord-296347-fanlvxqs	445	23	reactivation	reactivation	NN
cord-296347-fanlvxqs	445	24	ensure	ensure	VBP
cord-296347-fanlvxqs	445	25	transmission	transmission	NN
cord-296347-fanlvxqs	445	26	to	to	IN
cord-296347-fanlvxqs	445	27	a	a	DT
cord-296347-fanlvxqs	445	28	new	new	JJ
cord-296347-fanlvxqs	445	29	host	host	NN
cord-296347-fanlvxqs	445	30	,	,	,
cord-296347-fanlvxqs	445	31	and	and	CC
cord-296347-fanlvxqs	445	32	thus	thus	RB
cord-296347-fanlvxqs	445	33	survival	survival	NN
cord-296347-fanlvxqs	445	34	of	of	IN
cord-296347-fanlvxqs	445	35	both	both	DT
cord-296347-fanlvxqs	445	36	host	host	NN
cord-296347-fanlvxqs	445	37	and	and	CC
cord-296347-fanlvxqs	445	38	virus	virus	NN
cord-296347-fanlvxqs	445	39	.	.	.
cord-296347-fanlvxqs	446	1	Perturbation	perturbation	NN
cord-296347-fanlvxqs	446	2	of	of	IN
cord-296347-fanlvxqs	446	3	this	this	DT
cord-296347-fanlvxqs	446	4	delicate	delicate	JJ
cord-296347-fanlvxqs	446	5	balance	balance	NN
cord-296347-fanlvxqs	446	6	leads	lead	VBZ
cord-296347-fanlvxqs	446	7	to	to	IN
cord-296347-fanlvxqs	446	8	life	life	NN
cord-296347-fanlvxqs	446	9	-	-	HYPH
cord-296347-fanlvxqs	446	10	threatening	threaten	VBG
cord-296347-fanlvxqs	446	11	infections	infection	NNS
cord-296347-fanlvxqs	446	12	in	in	IN
cord-296347-fanlvxqs	446	13	immunocompromised	immunocompromised	JJ
cord-296347-fanlvxqs	446	14	patients	patient	NNS
cord-296347-fanlvxqs	446	15	,	,	,
cord-296347-fanlvxqs	446	16	transplant	transplant	NN
cord-296347-fanlvxqs	446	17	recipients	recipient	NNS
cord-296347-fanlvxqs	446	18	and	and	CC
cord-296347-fanlvxqs	446	19	infected	infect	VBN
cord-296347-fanlvxqs	446	20	newborns	newborn	NNS
cord-296347-fanlvxqs	446	21	and	and	CC
cord-296347-fanlvxqs	446	22	illustrates	illustrate	VBZ
cord-296347-fanlvxqs	446	23	how	how	WRB
cord-296347-fanlvxqs	446	24	the	the	DT
cord-296347-fanlvxqs	446	25	outcome	outcome	NN
cord-296347-fanlvxqs	446	26	of	of	IN
cord-296347-fanlvxqs	446	27	this	this	DT
cord-296347-fanlvxqs	446	28	host	host	NN
cord-296347-fanlvxqs	446	29	-	-	HYPH
cord-296347-fanlvxqs	446	30	virus	virus	NN
cord-296347-fanlvxqs	446	31	relationship	relationship	NN
cord-296347-fanlvxqs	446	32	is	be	VBZ
cord-296347-fanlvxqs	446	33	dependent	dependent	JJ
cord-296347-fanlvxqs	446	34	on	on	IN
cord-296347-fanlvxqs	446	35	viral	viral	JJ
cord-296347-fanlvxqs	446	36	manipulation	manipulation	NN
cord-296347-fanlvxqs	446	37	of	of	IN
cord-296347-fanlvxqs	446	38	the	the	DT
cord-296347-fanlvxqs	446	39	host	host	NN
cord-296347-fanlvxqs	446	40	immune	immune	JJ
cord-296347-fanlvxqs	446	41	response	response	NN
cord-296347-fanlvxqs	446	42	(	(	-LRB-
cord-296347-fanlvxqs	446	43	Hengel	Hengel	NNP
cord-296347-fanlvxqs	446	44	et	et	NNP
cord-296347-fanlvxqs	446	45	al	al	NNP
cord-296347-fanlvxqs	446	46	.	.	NNP
cord-296347-fanlvxqs	446	47	,	,	,
cord-296347-fanlvxqs	446	48	1998	1998	CD
cord-296347-fanlvxqs	446	49	;	;	:
cord-296347-fanlvxqs	446	50	Klenerman	Klenerman	NNP
cord-296347-fanlvxqs	446	51	and	and	CC
cord-296347-fanlvxqs	446	52	Hill	Hill	NNP
cord-296347-fanlvxqs	446	53	,	,	,
cord-296347-fanlvxqs	446	54	2005	2005	CD
cord-296347-fanlvxqs	446	55	)	)	-RRB-
cord-296347-fanlvxqs	446	56	.	.	.
cord-296347-fanlvxqs	447	1	The	the	DT
cord-296347-fanlvxqs	447	2	several	several	JJ
cord-296347-fanlvxqs	447	3	HCMV	HCMV	NNP
cord-296347-fanlvxqs	447	4	-	-	HYPH
cord-296347-fanlvxqs	447	5	encoded	encode	VBN
cord-296347-fanlvxqs	447	6	immunoevasins	immunoevasin	NNS
cord-296347-fanlvxqs	447	7	(	(	-LRB-
cord-296347-fanlvxqs	447	8	Jones	Jones	NNP
cord-296347-fanlvxqs	447	9	et	et	NNP
cord-296347-fanlvxqs	447	10	al	al	NNP
cord-296347-fanlvxqs	447	11	.	.	NNP
cord-296347-fanlvxqs	447	12	,	,	,
cord-296347-fanlvxqs	447	13	1995	1995	CD
cord-296347-fanlvxqs	447	14	)	)	-RRB-
cord-296347-fanlvxqs	447	15	are	be	VBP
cord-296347-fanlvxqs	447	16	presumably	presumably	RB
cord-296347-fanlvxqs	447	17	aimed	aim	VBN
cord-296347-fanlvxqs	447	18	primarily	primarily	RB
cord-296347-fanlvxqs	447	19	,	,	,
cord-296347-fanlvxqs	447	20	but	but	CC
cord-296347-fanlvxqs	447	21	not	not	RB
cord-296347-fanlvxqs	447	22	solely	solely	RB
cord-296347-fanlvxqs	447	23	,	,	,
cord-296347-fanlvxqs	447	24	at	at	IN
cord-296347-fanlvxqs	447	25	control	control	NN
cord-296347-fanlvxqs	447	26	of	of	IN
cord-296347-fanlvxqs	447	27	the	the	DT
cord-296347-fanlvxqs	447	28	CD8	CD8	NNP
cord-296347-fanlvxqs	447	29	þ	þ	NNP
cord-296347-fanlvxqs	447	30	T	T	NNP
cord-296347-fanlvxqs	447	31	cell	cell	NN
cord-296347-fanlvxqs	447	32	and	and	CC
cord-296347-fanlvxqs	447	33	NK	NK	NNP
cord-296347-fanlvxqs	447	34	cell	cell	NN
cord-296347-fanlvxqs	447	35	responses	response	NNS
cord-296347-fanlvxqs	447	36	(	(	-LRB-
cord-296347-fanlvxqs	447	37	Falk	Falk	NNP
cord-296347-fanlvxqs	447	38	et	et	NNP
cord-296347-fanlvxqs	447	39	al	al	NNP
cord-296347-fanlvxqs	447	40	.	.	.
cord-296347-fanlvxqs	448	1	,	,	,
cord-296347-fanlvxqs	448	2	2002	2002	CD
cord-296347-fanlvxqs	448	3	;	;	:
cord-296347-fanlvxqs	448	4	Mocarski	Mocarski	NNP
cord-296347-fanlvxqs	448	5	,	,	,
cord-296347-fanlvxqs	448	6	2004	2004	CD
cord-296347-fanlvxqs	448	7	;	;	:
cord-296347-fanlvxqs	448	8	Pinto	Pinto	NNP
cord-296347-fanlvxqs	448	9	and	and	CC
cord-296347-fanlvxqs	448	10	Hill	Hill	NNP
cord-296347-fanlvxqs	448	11	,	,	,
cord-296347-fanlvxqs	448	12	2005	2005	CD
cord-296347-fanlvxqs	448	13	;	;	:
cord-296347-fanlvxqs	448	14	Yewdell	Yewdell	NNP
cord-296347-fanlvxqs	448	15	and	and	CC
cord-296347-fanlvxqs	448	16	Hill	Hill	NNP
cord-296347-fanlvxqs	448	17	,	,	,
cord-296347-fanlvxqs	448	18	2002	2002	CD
cord-296347-fanlvxqs	448	19	)	)	-RRB-
cord-296347-fanlvxqs	448	20	.	.	.
cord-296347-fanlvxqs	449	1	Here	here	RB
cord-296347-fanlvxqs	449	2	we	-PRON-	PRP
cord-296347-fanlvxqs	449	3	will	will	MD
cord-296347-fanlvxqs	449	4	discuss	discuss	VB
cord-296347-fanlvxqs	449	5	the	the	DT
cord-296347-fanlvxqs	449	6	HCMV	HCMV	NNP
cord-296347-fanlvxqs	449	7	immunoevasins	immunoevasin	NNS
cord-296347-fanlvxqs	449	8	that	that	WDT
cord-296347-fanlvxqs	449	9	interfere	interfere	VBP
cord-296347-fanlvxqs	449	10	with	with	IN
cord-296347-fanlvxqs	449	11	class	class	NN
cord-296347-fanlvxqs	449	12	I	-PRON-	PRP
cord-296347-fanlvxqs	449	13	MHC	MHC	NNP
cord-296347-fanlvxqs	449	14	antigen	antigen	NN
cord-296347-fanlvxqs	449	15	presentation	presentation	NN
cord-296347-fanlvxqs	449	16	,	,	,
cord-296347-fanlvxqs	449	17	US3	US3	NNP
cord-296347-fanlvxqs	449	18	,	,	,
cord-296347-fanlvxqs	449	19	US6	US6	NNP
cord-296347-fanlvxqs	449	20	,	,	,
cord-296347-fanlvxqs	449	21	US10	US10	NNP
cord-296347-fanlvxqs	449	22	,	,	,
cord-296347-fanlvxqs	449	23	US2	US2	NNP
cord-296347-fanlvxqs	449	24	,	,	,
cord-296347-fanlvxqs	449	25	US11	US11	NNP
cord-296347-fanlvxqs	449	26	,	,	,
cord-296347-fanlvxqs	449	27	UL16	UL16	NNP
cord-296347-fanlvxqs	449	28	,	,	,
cord-296347-fanlvxqs	449	29	UL18	UL18	NNP
cord-296347-fanlvxqs	449	30	,	,	,
cord-296347-fanlvxqs	449	31	UL40	UL40	NNP
cord-296347-fanlvxqs	449	32	,	,	,
cord-296347-fanlvxqs	449	33	UL141	UL141	NNP
cord-296347-fanlvxqs	449	34	,	,	,
cord-296347-fanlvxqs	449	35	and	and	CC
cord-296347-fanlvxqs	449	36	UL142	ul142	NN
cord-296347-fanlvxqs	449	37	.	.	.
cord-296347-fanlvxqs	450	1	In	in	IN
cord-296347-fanlvxqs	450	2	light	light	NN
cord-296347-fanlvxqs	450	3	of	of	IN
cord-296347-fanlvxqs	450	4	our	-PRON-	PRP$
cord-296347-fanlvxqs	450	5	most	most	RBS
cord-296347-fanlvxqs	450	6	recent	recent	JJ
cord-296347-fanlvxqs	450	7	findings	finding	NNS
cord-296347-fanlvxqs	450	8	,	,	,
cord-296347-fanlvxqs	450	9	we	-PRON-	PRP
cord-296347-fanlvxqs	450	10	will	will	MD
cord-296347-fanlvxqs	450	11	elaborate	elaborate	VB
cord-296347-fanlvxqs	450	12	on	on	IN
cord-296347-fanlvxqs	450	13	the	the	DT
cord-296347-fanlvxqs	450	14	mechanism	mechanism	NN
cord-296347-fanlvxqs	450	15	of	of	IN
cord-296347-fanlvxqs	450	16	ER	ER	NNP
cord-296347-fanlvxqs	450	17	dislocation	dislocation	NN
cord-296347-fanlvxqs	450	18	co	co	NN
cord-296347-fanlvxqs	450	19	-	-	VBN
cord-296347-fanlvxqs	450	20	opted	opt	VBN
cord-296347-fanlvxqs	450	21	by	by	IN
cord-296347-fanlvxqs	450	22	the	the	DT
cord-296347-fanlvxqs	450	23	HCMV	HCMV	NNP
cord-296347-fanlvxqs	450	24	US2	US2	NNP
cord-296347-fanlvxqs	450	25	and	and	CC
cord-296347-fanlvxqs	450	26	US11	US11	NNP
cord-296347-fanlvxqs	450	27	immunoevasins	immunoevasin	NNS
cord-296347-fanlvxqs	450	28	.	.	.
cord-296347-fanlvxqs	451	1	More	more	RBR
cord-296347-fanlvxqs	451	2	specifically	specifically	RB
cord-296347-fanlvxqs	451	3	,	,	,
cord-296347-fanlvxqs	451	4	we	-PRON-	PRP
cord-296347-fanlvxqs	451	5	discuss	discuss	VBP
cord-296347-fanlvxqs	451	6	the	the	DT
cord-296347-fanlvxqs	451	7	similarities	similarity	NNS
cord-296347-fanlvxqs	451	8	and	and	CC
cord-296347-fanlvxqs	451	9	the	the	DT
cord-296347-fanlvxqs	451	10	differences	difference	NNS
cord-296347-fanlvxqs	451	11	between	between	IN
cord-296347-fanlvxqs	451	12	the	the	DT
cord-296347-fanlvxqs	451	13	two	two	CD
cord-296347-fanlvxqs	451	14	cellular	cellular	JJ
cord-296347-fanlvxqs	451	15	ERAD	ERAD	NNP
cord-296347-fanlvxqs	451	16	pathways	pathway	NNS
cord-296347-fanlvxqs	451	17	that	that	WDT
cord-296347-fanlvxqs	451	18	US2	US2	NNP
cord-296347-fanlvxqs	451	19	and	and	CC
cord-296347-fanlvxqs	451	20	US11	US11	NNP
cord-296347-fanlvxqs	451	21	have	have	VBP
cord-296347-fanlvxqs	451	22	allowed	allow	VBN
cord-296347-fanlvxqs	451	23	us	-PRON-	PRP
cord-296347-fanlvxqs	451	24	to	to	TO
cord-296347-fanlvxqs	451	25	uncover	uncover	VB
cord-296347-fanlvxqs	451	26	and	and	CC
cord-296347-fanlvxqs	451	27	the	the	DT
cord-296347-fanlvxqs	451	28	possible	possible	JJ
cord-296347-fanlvxqs	451	29	implications	implication	NNS
cord-296347-fanlvxqs	451	30	for	for	IN
cord-296347-fanlvxqs	451	31	ER	ER	NNP
cord-296347-fanlvxqs	451	32	dislocation	dislocation	NN
cord-296347-fanlvxqs	451	33	.	.	.
cord-296347-fanlvxqs	452	1	We	-PRON-	PRP
cord-296347-fanlvxqs	452	2	will	will	MD
cord-296347-fanlvxqs	452	3	extend	extend	VB
cord-296347-fanlvxqs	452	4	this	this	DT
cord-296347-fanlvxqs	452	5	by	by	IN
cord-296347-fanlvxqs	452	6	comparing	compare	VBG
cord-296347-fanlvxqs	452	7	the	the	DT
cord-296347-fanlvxqs	452	8	HCMV	HCMV	NNP
cord-296347-fanlvxqs	452	9	US2-and	US2-and	NNP
cord-296347-fanlvxqs	452	10	US11-mediated	us11-mediated	CD
cord-296347-fanlvxqs	452	11	dislocation	dislocation	NN
cord-296347-fanlvxqs	452	12	of	of	IN
cord-296347-fanlvxqs	452	13	human	human	JJ
cord-296347-fanlvxqs	452	14	class	class	NN
cord-296347-fanlvxqs	452	15	I	-PRON-	PRP
cord-296347-fanlvxqs	452	16	MHC	MHC	NNP
cord-296347-fanlvxqs	452	17	HC	HC	NNP
cord-296347-fanlvxqs	452	18	molecules	molecule	NNS
cord-296347-fanlvxqs	452	19	with	with	IN
cord-296347-fanlvxqs	452	20	dislocation	dislocation	NN
cord-296347-fanlvxqs	452	21	of	of	IN
cord-296347-fanlvxqs	452	22	murine	murine	JJ
cord-296347-fanlvxqs	452	23	HCs	hc	NNS
cord-296347-fanlvxqs	452	24	by	by	IN
cord-296347-fanlvxqs	452	25	the	the	DT
cord-296347-fanlvxqs	452	26	MHV-68	MHV-68	NNP
cord-296347-fanlvxqs	452	27	mK3	mK3	NNP
cord-296347-fanlvxqs	452	28	immunoevasin	immunoevasin	NNP
cord-296347-fanlvxqs	452	29	.	.	.
cord-296347-fanlvxqs	453	1	If	if	IN
cord-296347-fanlvxqs	453	2	one	one	PRP
cord-296347-fanlvxqs	453	3	goes	go	VBZ
cord-296347-fanlvxqs	453	4	back	back	RB
cord-296347-fanlvxqs	453	5	to	to	IN
cord-296347-fanlvxqs	453	6	the	the	DT
cord-296347-fanlvxqs	453	7	steps	step	NNS
cord-296347-fanlvxqs	453	8	we	-PRON-	PRP
cord-296347-fanlvxqs	453	9	depicted	depict	VBD
cord-296347-fanlvxqs	453	10	for	for	IN
cord-296347-fanlvxqs	453	11	antigen	antigen	NN
cord-296347-fanlvxqs	453	12	presentation	presentation	NN
cord-296347-fanlvxqs	453	13	(	(	-LRB-
cord-296347-fanlvxqs	453	14	Fig	Fig	NNP
cord-296347-fanlvxqs	453	15	.	.	.
cord-296347-fanlvxqs	453	16	1	1	CD
cord-296347-fanlvxqs	453	17	)	)	-RRB-
cord-296347-fanlvxqs	453	18	and	and	CC
cord-296347-fanlvxqs	453	19	then	then	RB
cord-296347-fanlvxqs	453	20	examines	examine	VBZ
cord-296347-fanlvxqs	453	21	the	the	DT
cord-296347-fanlvxqs	453	22	immunoevasins	immunoevasin	NNS
cord-296347-fanlvxqs	453	23	encoded	encode	VBN
cord-296347-fanlvxqs	453	24	by	by	IN
cord-296347-fanlvxqs	453	25	HCMV	HCMV	NNP
cord-296347-fanlvxqs	453	26	,	,	,
cord-296347-fanlvxqs	453	27	we	-PRON-	PRP
cord-296347-fanlvxqs	453	28	will	will	MD
cord-296347-fanlvxqs	453	29	find	find	VB
cord-296347-fanlvxqs	453	30	that	that	IN
cord-296347-fanlvxqs	453	31	this	this	DT
cord-296347-fanlvxqs	453	32	herpesvirus	herpesvirus	NN
cord-296347-fanlvxqs	453	33	exploits	exploit	VBZ
cord-296347-fanlvxqs	453	34	many	many	JJ
cord-296347-fanlvxqs	453	35	aspects	aspect	NNS
cord-296347-fanlvxqs	453	36	of	of	IN
cord-296347-fanlvxqs	453	37	the	the	DT
cord-296347-fanlvxqs	453	38	antigen	antigen	NN
cord-296347-fanlvxqs	453	39	presentation	presentation	NN
cord-296347-fanlvxqs	453	40	pathway	pathway	NN
cord-296347-fanlvxqs	453	41	thus	thus	RB
cord-296347-fanlvxqs	453	42	defined	define	VBN
cord-296347-fanlvxqs	453	43	.	.	.
cord-296347-fanlvxqs	454	1	The	the	DT
cord-296347-fanlvxqs	454	2	HCMV	HCMV	NNP
cord-296347-fanlvxqs	454	3	phosphoprotein	phosphoprotein	NN
cord-296347-fanlvxqs	454	4	pp65	pp65	NNP
cord-296347-fanlvxqs	454	5	tegument	tegument	NNP
cord-296347-fanlvxqs	454	6	protein	protein	NN
cord-296347-fanlvxqs	454	7	mediates	mediate	VBZ
cord-296347-fanlvxqs	454	8	the	the	DT
cord-296347-fanlvxqs	454	9	phosphorylation	phosphorylation	NN
cord-296347-fanlvxqs	454	10	of	of	IN
cord-296347-fanlvxqs	454	11	the	the	DT
cord-296347-fanlvxqs	454	12	HCMV	HCMV	NNP
cord-296347-fanlvxqs	454	13	immediate	immediate	JJ
cord-296347-fanlvxqs	454	14	early	early	JJ
cord-296347-fanlvxqs	454	15	antigen-1	antigen-1	NNP
cord-296347-fanlvxqs	455	1	(	(	-LRB-
cord-296347-fanlvxqs	455	2	IE-1	IE-1	NNP
cord-296347-fanlvxqs	455	3	)	)	-RRB-
cord-296347-fanlvxqs	455	4	during	during	IN
cord-296347-fanlvxqs	455	5	HCMV	HCMV	NNP
cord-296347-fanlvxqs	455	6	infection	infection	NN
cord-296347-fanlvxqs	455	7	.	.	.
cord-296347-fanlvxqs	456	1	Phosphorylation	Phosphorylation	NNP
cord-296347-fanlvxqs	456	2	of	of	IN
cord-296347-fanlvxqs	456	3	IE-1	IE-1	NNP
cord-296347-fanlvxqs	456	4	interferes	interfere	VBZ
cord-296347-fanlvxqs	456	5	with	with	IN
cord-296347-fanlvxqs	456	6	the	the	DT
cord-296347-fanlvxqs	456	7	presentation	presentation	NN
cord-296347-fanlvxqs	456	8	of	of	IN
cord-296347-fanlvxqs	456	9	IE-1-derived	ie-1-derived	CD
cord-296347-fanlvxqs	456	10	antigens	antigen	NNS
cord-296347-fanlvxqs	456	11	(	(	-LRB-
cord-296347-fanlvxqs	456	12	Gilbert	Gilbert	NNP
cord-296347-fanlvxqs	456	13	et	et	NNP
cord-296347-fanlvxqs	456	14	al	al	NNP
cord-296347-fanlvxqs	456	15	.	.	NNP
cord-296347-fanlvxqs	456	16	,	,	,
cord-296347-fanlvxqs	456	17	1996	1996	CD
cord-296347-fanlvxqs	456	18	)	)	-RRB-
cord-296347-fanlvxqs	456	19	.	.	.
cord-296347-fanlvxqs	457	1	The	the	DT
cord-296347-fanlvxqs	457	2	US3	US3	NNP
cord-296347-fanlvxqs	457	3	protein	protein	NN
cord-296347-fanlvxqs	457	4	binds	bind	VBZ
cord-296347-fanlvxqs	457	5	to	to	IN
cord-296347-fanlvxqs	457	6	and	and	CC
cord-296347-fanlvxqs	457	7	retains	retain	VBZ
cord-296347-fanlvxqs	457	8	some	some	DT
cord-296347-fanlvxqs	457	9	class	class	NN
cord-296347-fanlvxqs	457	10	I	-PRON-	PRP
cord-296347-fanlvxqs	457	11	MHC	MHC	NNP
cord-296347-fanlvxqs	457	12	locus	locus	NN
cord-296347-fanlvxqs	457	13	products	product	NNS
cord-296347-fanlvxqs	457	14	in	in	IN
cord-296347-fanlvxqs	457	15	the	the	DT
cord-296347-fanlvxqs	457	16	ER	ER	NNP
cord-296347-fanlvxqs	457	17	membrane	membrane	NN
cord-296347-fanlvxqs	457	18	(	(	-LRB-
cord-296347-fanlvxqs	458	1	Ahn	Ahn	NNP
cord-296347-fanlvxqs	458	2	et	et	NNP
cord-296347-fanlvxqs	458	3	al	al	NNP
cord-296347-fanlvxqs	458	4	.	.	.
cord-296347-fanlvxqs	459	1	,	,	,
cord-296347-fanlvxqs	459	2	1996	1996	CD
cord-296347-fanlvxqs	459	3	;	;	:
cord-296347-fanlvxqs	459	4	Jones	Jones	NNP
cord-296347-fanlvxqs	459	5	et	et	NNP
cord-296347-fanlvxqs	459	6	al	al	NNP
cord-296347-fanlvxqs	459	7	.	.	NNP
cord-296347-fanlvxqs	459	8	,	,	,
cord-296347-fanlvxqs	459	9	1996	1996	CD
cord-296347-fanlvxqs	459	10	)	)	-RRB-
cord-296347-fanlvxqs	459	11	.	.	.
cord-296347-fanlvxqs	460	1	US3	US3	NNP
cord-296347-fanlvxqs	460	2	is	be	VBZ
cord-296347-fanlvxqs	460	3	a	a	DT
cord-296347-fanlvxqs	460	4	type	type	NN
cord-296347-fanlvxqs	460	5	I	-PRON-	PRP
cord-296347-fanlvxqs	460	6	membrane	membrane	VBP
cord-296347-fanlvxqs	460	7	glycoprotein	glycoprotein	NN
cord-296347-fanlvxqs	460	8	with	with	IN
cord-296347-fanlvxqs	460	9	an	an	DT
cord-296347-fanlvxqs	460	10	Ig	Ig	NNP
cord-296347-fanlvxqs	460	11	-	-	HYPH
cord-296347-fanlvxqs	460	12	like	like	JJ
cord-296347-fanlvxqs	460	13	lumenal	lumenal	JJ
cord-296347-fanlvxqs	460	14	domain	domain	NN
cord-296347-fanlvxqs	460	15	that	that	WDT
cord-296347-fanlvxqs	460	16	is	be	VBZ
cord-296347-fanlvxqs	460	17	essential	essential	JJ
cord-296347-fanlvxqs	460	18	for	for	IN
cord-296347-fanlvxqs	460	19	its	-PRON-	PRP$
cord-296347-fanlvxqs	460	20	own	own	JJ
cord-296347-fanlvxqs	460	21	retention	retention	NN
cord-296347-fanlvxqs	460	22	,	,	,
cord-296347-fanlvxqs	460	23	albeit	albeit	IN
cord-296347-fanlvxqs	460	24	transient	transient	JJ
cord-296347-fanlvxqs	460	25	,	,	,
cord-296347-fanlvxqs	460	26	in	in	IN
cord-296347-fanlvxqs	460	27	the	the	DT
cord-296347-fanlvxqs	460	28	ER	er	NN
cord-296347-fanlvxqs	461	1	(	(	-LRB-
cord-296347-fanlvxqs	461	2	Lee	Lee	NNP
cord-296347-fanlvxqs	461	3	et	et	NNP
cord-296347-fanlvxqs	461	4	al	al	NNP
cord-296347-fanlvxqs	461	5	.	.	NNP
cord-296347-fanlvxqs	461	6	,	,	,
cord-296347-fanlvxqs	461	7	2003	2003	CD
cord-296347-fanlvxqs	461	8	)	)	-RRB-
cord-296347-fanlvxqs	461	9	.	.	.
cord-296347-fanlvxqs	462	1	US3	US3	NNP
cord-296347-fanlvxqs	462	2	eventually	eventually	RB
cord-296347-fanlvxqs	462	3	travels	travel	VBZ
cord-296347-fanlvxqs	462	4	to	to	IN
cord-296347-fanlvxqs	462	5	the	the	DT
cord-296347-fanlvxqs	462	6	lysosome	lysosome	NN
cord-296347-fanlvxqs	462	7	where	where	WRB
cord-296347-fanlvxqs	462	8	it	-PRON-	PRP
cord-296347-fanlvxqs	462	9	is	be	VBZ
cord-296347-fanlvxqs	462	10	degraded	degrade	VBN
cord-296347-fanlvxqs	463	1	(	(	-LRB-
cord-296347-fanlvxqs	463	2	Gruhler	Gruhler	NNP
cord-296347-fanlvxqs	463	3	et	et	NNP
cord-296347-fanlvxqs	463	4	al	al	NNP
cord-296347-fanlvxqs	463	5	.	.	NNP
cord-296347-fanlvxqs	463	6	,	,	,
cord-296347-fanlvxqs	463	7	2000	2000	CD
cord-296347-fanlvxqs	463	8	)	)	-RRB-
cord-296347-fanlvxqs	463	9	.	.	.
cord-296347-fanlvxqs	464	1	Some	some	DT
cord-296347-fanlvxqs	464	2	evidence	evidence	NN
cord-296347-fanlvxqs	464	3	suggests	suggest	VBZ
cord-296347-fanlvxqs	464	4	that	that	IN
cord-296347-fanlvxqs	464	5	ER	ER	NNP
cord-296347-fanlvxqs	464	6	retention	retention	NN
cord-296347-fanlvxqs	464	7	of	of	IN
cord-296347-fanlvxqs	464	8	class	class	NN
cord-296347-fanlvxqs	465	1	I	-PRON-	PRP
cord-296347-fanlvxqs	465	2	MHC	MHC	NNP
cord-296347-fanlvxqs	465	3	complexes	complex	NNS
cord-296347-fanlvxqs	465	4	by	by	IN
cord-296347-fanlvxqs	465	5	US3	US3	NNP
cord-296347-fanlvxqs	465	6	depends	depend	VBZ
cord-296347-fanlvxqs	465	7	on	on	IN
cord-296347-fanlvxqs	465	8	the	the	DT
cord-296347-fanlvxqs	465	9	ER	ER	NNP
cord-296347-fanlvxqs	465	10	localization	localization	NN
cord-296347-fanlvxqs	465	11	signal	signal	NN
cord-296347-fanlvxqs	465	12	on	on	IN
cord-296347-fanlvxqs	465	13	US3	US3	NNP
cord-296347-fanlvxqs	465	14	and	and	CC
cord-296347-fanlvxqs	465	15	perhaps	perhaps	RB
cord-296347-fanlvxqs	465	16	the	the	DT
cord-296347-fanlvxqs	465	17	ability	ability	NN
cord-296347-fanlvxqs	465	18	of	of	IN
cord-296347-fanlvxqs	465	19	the	the	DT
cord-296347-fanlvxqs	465	20	US3	US3	NNP
cord-296347-fanlvxqs	465	21	luminal	luminal	JJ
cord-296347-fanlvxqs	465	22	domain	domain	NN
cord-296347-fanlvxqs	465	23	to	to	IN
cord-296347-fanlvxqs	465	24	oligomerize	oligomerize	NNP
cord-296347-fanlvxqs	465	25	(	(	-LRB-
cord-296347-fanlvxqs	465	26	Misaghi	Misaghi	NNP
cord-296347-fanlvxqs	465	27	et	et	NNP
cord-296347-fanlvxqs	465	28	al	al	NNP
cord-296347-fanlvxqs	465	29	.	.	NNP
cord-296347-fanlvxqs	465	30	,	,	,
cord-296347-fanlvxqs	465	31	2004b	2004b	CD
cord-296347-fanlvxqs	465	32	)	)	-RRB-
cord-296347-fanlvxqs	465	33	as	as	IN
cord-296347-fanlvxqs	465	34	determinants	determinant	NNS
cord-296347-fanlvxqs	465	35	of	of	IN
cord-296347-fanlvxqs	465	36	retention	retention	NN
cord-296347-fanlvxqs	465	37	of	of	IN
cord-296347-fanlvxqs	465	38	both	both	DT
cord-296347-fanlvxqs	465	39	molecules	molecule	NNS
cord-296347-fanlvxqs	465	40	(	(	-LRB-
cord-296347-fanlvxqs	465	41	Lee	Lee	NNP
cord-296347-fanlvxqs	465	42	et	et	NNP
cord-296347-fanlvxqs	465	43	al	al	NNP
cord-296347-fanlvxqs	465	44	.	.	NNP
cord-296347-fanlvxqs	465	45	,	,	,
cord-296347-fanlvxqs	465	46	2003	2003	CD
cord-296347-fanlvxqs	465	47	)	)	-RRB-
cord-296347-fanlvxqs	465	48	.	.	.
cord-296347-fanlvxqs	466	1	Another	another	DT
cord-296347-fanlvxqs	466	2	model	model	NN
cord-296347-fanlvxqs	466	3	suggests	suggest	VBZ
cord-296347-fanlvxqs	466	4	that	that	IN
cord-296347-fanlvxqs	466	5	association	association	NN
cord-296347-fanlvxqs	466	6	of	of	IN
cord-296347-fanlvxqs	466	7	US3	US3	NNP
cord-296347-fanlvxqs	466	8	with	with	IN
cord-296347-fanlvxqs	466	9	tapasin	tapasin	NNP
cord-296347-fanlvxqs	466	10	,	,	,
cord-296347-fanlvxqs	466	11	which	which	WDT
cord-296347-fanlvxqs	466	12	inhibits	inhibit	VBZ
cord-296347-fanlvxqs	466	13	tapasin	tapasin	NNP
cord-296347-fanlvxqs	466	14	,	,	,
cord-296347-fanlvxqs	466	15	is	be	VBZ
cord-296347-fanlvxqs	466	16	sufficient	sufficient	JJ
cord-296347-fanlvxqs	466	17	to	to	TO
cord-296347-fanlvxqs	466	18	mediate	mediate	VB
cord-296347-fanlvxqs	466	19	ER	ER	NNP
cord-296347-fanlvxqs	466	20	retention	retention	NN
cord-296347-fanlvxqs	466	21	(	(	-LRB-
cord-296347-fanlvxqs	466	22	Park	Park	NNP
cord-296347-fanlvxqs	466	23	et	et	FW
cord-296347-fanlvxqs	466	24	al	al	NNP
cord-296347-fanlvxqs	466	25	.	.	NNP
cord-296347-fanlvxqs	466	26	,	,	,
cord-296347-fanlvxqs	466	27	2004	2004	CD
cord-296347-fanlvxqs	466	28	)	)	-RRB-
cord-296347-fanlvxqs	466	29	.	.	.
cord-296347-fanlvxqs	467	1	Class	class	NN
cord-296347-fanlvxqs	467	2	I	-PRON-	PRP
cord-296347-fanlvxqs	467	3	MHC	MHC	NNP
cord-296347-fanlvxqs	467	4	alleles	allele	NNS
cord-296347-fanlvxqs	467	5	that	that	WDT
cord-296347-fanlvxqs	467	6	require	require	VBP
cord-296347-fanlvxqs	467	7	peptide	peptide	JJ
cord-296347-fanlvxqs	467	8	optimization	optimization	NN
cord-296347-fanlvxqs	467	9	by	by	IN
cord-296347-fanlvxqs	467	10	tapasin	tapasin	NNP
cord-296347-fanlvxqs	467	11	may	may	MD
cord-296347-fanlvxqs	467	12	be	be	VB
cord-296347-fanlvxqs	467	13	retained	retain	VBN
cord-296347-fanlvxqs	467	14	in	in	IN
cord-296347-fanlvxqs	467	15	the	the	DT
cord-296347-fanlvxqs	467	16	ER	ER	NNP
cord-296347-fanlvxqs	467	17	,	,	,
cord-296347-fanlvxqs	467	18	whereas	whereas	IN
cord-296347-fanlvxqs	467	19	tapasin	tapasin	NN
cord-296347-fanlvxqs	467	20	-	-	HYPH
cord-296347-fanlvxqs	467	21	independent	independent	JJ
cord-296347-fanlvxqs	467	22	locus	locus	NN
cord-296347-fanlvxqs	467	23	MHC	MHC	NNP
cord-296347-fanlvxqs	467	24	products	product	NNS
cord-296347-fanlvxqs	467	25	are	be	VBP
cord-296347-fanlvxqs	467	26	spared	spare	VBN
cord-296347-fanlvxqs	467	27	from	from	IN
cord-296347-fanlvxqs	467	28	retention	retention	NN
cord-296347-fanlvxqs	467	29	.	.	.
cord-296347-fanlvxqs	468	1	In	in	IN
cord-296347-fanlvxqs	468	2	fact	fact	NN
cord-296347-fanlvxqs	468	3	,	,	,
cord-296347-fanlvxqs	468	4	there	there	EX
cord-296347-fanlvxqs	468	5	is	be	VBZ
cord-296347-fanlvxqs	468	6	a	a	DT
cord-296347-fanlvxqs	468	7	perfect	perfect	JJ
cord-296347-fanlvxqs	468	8	correlation	correlation	NN
cord-296347-fanlvxqs	468	9	between	between	IN
cord-296347-fanlvxqs	468	10	tapasin	tapasin	NN
cord-296347-fanlvxqs	468	11	-	-	HYPH
cord-296347-fanlvxqs	468	12	dependence	dependence	NN
cord-296347-fanlvxqs	468	13	and	and	CC
cord-296347-fanlvxqs	468	14	US3	us3	NN
cord-296347-fanlvxqs	468	15	sensitivity	sensitivity	NN
cord-296347-fanlvxqs	468	16	(	(	-LRB-
cord-296347-fanlvxqs	468	17	Park	Park	NNP
cord-296347-fanlvxqs	468	18	et	et	FW
cord-296347-fanlvxqs	468	19	al	al	NNP
cord-296347-fanlvxqs	468	20	.	.	NNP
cord-296347-fanlvxqs	468	21	,	,	,
cord-296347-fanlvxqs	468	22	2004	2004	CD
cord-296347-fanlvxqs	468	23	)	)	-RRB-
cord-296347-fanlvxqs	468	24	.	.	.
cord-296347-fanlvxqs	469	1	Both	both	DT
cord-296347-fanlvxqs	469	2	mechanisms	mechanism	NNS
cord-296347-fanlvxqs	469	3	,	,	,
cord-296347-fanlvxqs	469	4	tapasin	tapasin	NN
cord-296347-fanlvxqs	469	5	inhibition	inhibition	NN
cord-296347-fanlvxqs	469	6	and	and	CC
cord-296347-fanlvxqs	469	7	direct	direct	JJ
cord-296347-fanlvxqs	469	8	binding	binding	NN
cord-296347-fanlvxqs	469	9	,	,	,
cord-296347-fanlvxqs	469	10	may	may	MD
cord-296347-fanlvxqs	469	11	be	be	VB
cord-296347-fanlvxqs	469	12	in	in	IN
cord-296347-fanlvxqs	469	13	place	place	NN
cord-296347-fanlvxqs	469	14	,	,	,
cord-296347-fanlvxqs	469	15	perhaps	perhaps	RB
cord-296347-fanlvxqs	469	16	allowing	allow	VBG
cord-296347-fanlvxqs	469	17	US3	US3	NNP
cord-296347-fanlvxqs	469	18	to	to	TO
cord-296347-fanlvxqs	469	19	retain	retain	VB
cord-296347-fanlvxqs	469	20	a	a	DT
cord-296347-fanlvxqs	469	21	larger	large	JJR
cord-296347-fanlvxqs	469	22	repertoire	repertoire	NN
cord-296347-fanlvxqs	469	23	of	of	IN
cord-296347-fanlvxqs	469	24	class	class	NN
cord-296347-fanlvxqs	469	25	I	-PRON-	PRP
cord-296347-fanlvxqs	469	26	MHC	MHC	NNP
cord-296347-fanlvxqs	469	27	locus	locus	NN
cord-296347-fanlvxqs	469	28	products	product	NNS
cord-296347-fanlvxqs	469	29	.	.	.
cord-296347-fanlvxqs	470	1	US6	US6	NNP
cord-296347-fanlvxqs	470	2	inhibits	inhibit	VBZ
cord-296347-fanlvxqs	470	3	peptide	peptide	JJ
cord-296347-fanlvxqs	470	4	loading	loading	NN
cord-296347-fanlvxqs	470	5	of	of	IN
cord-296347-fanlvxqs	470	6	the	the	DT
cord-296347-fanlvxqs	470	7	class	class	NN
cord-296347-fanlvxqs	470	8	I	-PRON-	PRP
cord-296347-fanlvxqs	470	9	MHC	MHC	NNP
cord-296347-fanlvxqs	470	10	molecules	molecule	NNS
cord-296347-fanlvxqs	470	11	by	by	IN
cord-296347-fanlvxqs	470	12	blocking	block	VBG
cord-296347-fanlvxqs	470	13	the	the	DT
cord-296347-fanlvxqs	470	14	TAP	TAP	NNP
cord-296347-fanlvxqs	470	15	transporter	transporter	NN
cord-296347-fanlvxqs	470	16	(	(	-LRB-
cord-296347-fanlvxqs	471	1	Ahn	Ahn	NNP
cord-296347-fanlvxqs	471	2	et	et	NNP
cord-296347-fanlvxqs	471	3	al	al	NNP
cord-296347-fanlvxqs	471	4	.	.	.
cord-296347-fanlvxqs	472	1	,	,	,
cord-296347-fanlvxqs	472	2	1997	1997	CD
cord-296347-fanlvxqs	472	3	;	;	:
cord-296347-fanlvxqs	472	4	Lehner	Lehner	NNP
cord-296347-fanlvxqs	472	5	et	et	NNP
cord-296347-fanlvxqs	472	6	al	al	NNP
cord-296347-fanlvxqs	472	7	.	.	NNP
cord-296347-fanlvxqs	472	8	,	,	,
cord-296347-fanlvxqs	472	9	1997	1997	CD
cord-296347-fanlvxqs	472	10	)	)	-RRB-
cord-296347-fanlvxqs	472	11	.	.	.
cord-296347-fanlvxqs	473	1	US6	US6	NNP
cord-296347-fanlvxqs	473	2	is	be	VBZ
cord-296347-fanlvxqs	473	3	an	an	DT
cord-296347-fanlvxqs	473	4	ER	ER	NNP
cord-296347-fanlvxqs	473	5	-	-	HYPH
cord-296347-fanlvxqs	473	6	resident	resident	NN
cord-296347-fanlvxqs	473	7	type	type	NN
cord-296347-fanlvxqs	473	8	I	-PRON-	PRP
cord-296347-fanlvxqs	473	9	membrane	membrane	VBP
cord-296347-fanlvxqs	473	10	glycoprotein	glycoprotein	NN
cord-296347-fanlvxqs	473	11	with	with	IN
cord-296347-fanlvxqs	473	12	a	a	DT
cord-296347-fanlvxqs	473	13	bulky	bulky	JJ
cord-296347-fanlvxqs	473	14	lumenal	lumenal	JJ
cord-296347-fanlvxqs	473	15	domain	domain	NN
cord-296347-fanlvxqs	473	16	that	that	WDT
cord-296347-fanlvxqs	473	17	binds	bind	VBZ
cord-296347-fanlvxqs	473	18	the	the	DT
cord-296347-fanlvxqs	473	19	core	core	NN
cord-296347-fanlvxqs	473	20	transmembrane	transmembrane	NN
cord-296347-fanlvxqs	473	21	domains	domain	NNS
cord-296347-fanlvxqs	473	22	of	of	IN
cord-296347-fanlvxqs	473	23	the	the	DT
cord-296347-fanlvxqs	473	24	TAP	tap	NN
cord-296347-fanlvxqs	473	25	subunits	subunit	NNS
cord-296347-fanlvxqs	473	26	,	,	,
cord-296347-fanlvxqs	473	27	TAP	tap	NN
cord-296347-fanlvxqs	473	28	1	1	CD
cord-296347-fanlvxqs	473	29	and	and	CC
cord-296347-fanlvxqs	473	30	TAP	TAP	NNP
cord-296347-fanlvxqs	473	31	2	2	CD
cord-296347-fanlvxqs	473	32	,	,	,
cord-296347-fanlvxqs	473	33	from	from	IN
cord-296347-fanlvxqs	473	34	within	within	IN
cord-296347-fanlvxqs	473	35	the	the	DT
cord-296347-fanlvxqs	473	36	ER	ER	NNP
cord-296347-fanlvxqs	473	37	lumen	lumen	NN
cord-296347-fanlvxqs	473	38	,	,	,
cord-296347-fanlvxqs	473	39	inhibiting	inhibit	VBG
cord-296347-fanlvxqs	473	40	ATP	ATP	NNP
cord-296347-fanlvxqs	473	41	binding	binding	NN
cord-296347-fanlvxqs	473	42	(	(	-LRB-
cord-296347-fanlvxqs	473	43	Hewitt	Hewitt	NNP
cord-296347-fanlvxqs	473	44	et	et	NNP
cord-296347-fanlvxqs	473	45	al	al	NNP
cord-296347-fanlvxqs	473	46	.	.	NNP
cord-296347-fanlvxqs	473	47	,	,	,
cord-296347-fanlvxqs	473	48	2001	2001	CD
cord-296347-fanlvxqs	473	49	;	;	:
cord-296347-fanlvxqs	473	50	Kyritsis	Kyritsis	NNP
cord-296347-fanlvxqs	473	51	et	et	NNP
cord-296347-fanlvxqs	473	52	al	al	NNP
cord-296347-fanlvxqs	473	53	.	.	NNP
cord-296347-fanlvxqs	473	54	,	,	,
cord-296347-fanlvxqs	473	55	2001	2001	CD
cord-296347-fanlvxqs	473	56	)	)	-RRB-
cord-296347-fanlvxqs	473	57	and	and	CC
cord-296347-fanlvxqs	473	58	thus	thus	RB
cord-296347-fanlvxqs	473	59	TAP	tap	NN
cord-296347-fanlvxqs	473	60	-	-	HYPH
cord-296347-fanlvxqs	473	61	mediated	mediate	VBN
cord-296347-fanlvxqs	473	62	peptide	peptide	NN
cord-296347-fanlvxqs	473	63	translocation	translocation	NN
cord-296347-fanlvxqs	473	64	into	into	IN
cord-296347-fanlvxqs	473	65	the	the	DT
cord-296347-fanlvxqs	473	66	ER	er	NN
cord-296347-fanlvxqs	473	67	.	.	.
cord-296347-fanlvxqs	474	1	The	the	DT
cord-296347-fanlvxqs	474	2	US6	us6	JJ
cord-296347-fanlvxqs	474	3	luminal	luminal	JJ
cord-296347-fanlvxqs	474	4	domain	domain	NN
cord-296347-fanlvxqs	474	5	oligomerizes	oligomerize	NNS
cord-296347-fanlvxqs	474	6	and	and	CC
cord-296347-fanlvxqs	474	7	may	may	MD
cord-296347-fanlvxqs	474	8	form	form	VB
cord-296347-fanlvxqs	474	9	a	a	DT
cord-296347-fanlvxqs	474	10	bridge	bridge	NN
cord-296347-fanlvxqs	474	11	between	between	IN
cord-296347-fanlvxqs	474	12	the	the	DT
cord-296347-fanlvxqs	474	13	TAP	TAP	NNP
cord-296347-fanlvxqs	474	14	1	1	CD
cord-296347-fanlvxqs	474	15	and	and	CC
cord-296347-fanlvxqs	474	16	TAP	tap	NN
cord-296347-fanlvxqs	474	17	2	2	CD
cord-296347-fanlvxqs	474	18	subunits	subunit	NNS
cord-296347-fanlvxqs	474	19	to	to	TO
cord-296347-fanlvxqs	474	20	effectively	effectively	RB
cord-296347-fanlvxqs	474	21	block	block	VB
cord-296347-fanlvxqs	474	22	TAP	tap	NN
cord-296347-fanlvxqs	474	23	activity	activity	NN
cord-296347-fanlvxqs	474	24	(	(	-LRB-
cord-296347-fanlvxqs	474	25	Halenius	Halenius	NNP
cord-296347-fanlvxqs	474	26	et	et	NNP
cord-296347-fanlvxqs	474	27	al	al	NNP
cord-296347-fanlvxqs	474	28	.	.	NNP
cord-296347-fanlvxqs	474	29	,	,	,
cord-296347-fanlvxqs	474	30	2006	2006	CD
cord-296347-fanlvxqs	474	31	)	)	-RRB-
cord-296347-fanlvxqs	474	32	.	.	.
cord-296347-fanlvxqs	475	1	US10	US10	NNP
cord-296347-fanlvxqs	475	2	delays	delay	NNS
cord-296347-fanlvxqs	475	3	trafficking	traffic	VBG
cord-296347-fanlvxqs	475	4	of	of	IN
cord-296347-fanlvxqs	475	5	class	class	NN
cord-296347-fanlvxqs	475	6	I	-PRON-	PRP
cord-296347-fanlvxqs	475	7	MHC	MHC	NNP
cord-296347-fanlvxqs	475	8	HCs	hc	NNS
cord-296347-fanlvxqs	475	9	and	and	CC
cord-296347-fanlvxqs	475	10	stalls	stall	VBZ
cord-296347-fanlvxqs	475	11	them	-PRON-	PRP
cord-296347-fanlvxqs	475	12	in	in	IN
cord-296347-fanlvxqs	475	13	the	the	DT
cord-296347-fanlvxqs	475	14	ER	ER	NNP
cord-296347-fanlvxqs	475	15	;	;	:
cord-296347-fanlvxqs	475	16	although	although	IN
cord-296347-fanlvxqs	475	17	the	the	DT
cord-296347-fanlvxqs	475	18	block	block	NN
cord-296347-fanlvxqs	475	19	is	be	VBZ
cord-296347-fanlvxqs	475	20	not	not	RB
cord-296347-fanlvxqs	475	21	absolute	absolute	JJ
cord-296347-fanlvxqs	475	22	and	and	CC
cord-296347-fanlvxqs	475	23	the	the	DT
cord-296347-fanlvxqs	475	24	mechanism	mechanism	NN
cord-296347-fanlvxqs	475	25	is	be	VBZ
cord-296347-fanlvxqs	475	26	poorly	poorly	RB
cord-296347-fanlvxqs	475	27	characterized	characterize	VBN
cord-296347-fanlvxqs	475	28	,	,	,
cord-296347-fanlvxqs	475	29	US10	us10	JJ
cord-296347-fanlvxqs	475	30	expression	expression	NN
cord-296347-fanlvxqs	475	31	results	result	VBZ
cord-296347-fanlvxqs	475	32	in	in	IN
cord-296347-fanlvxqs	475	33	downregulation	downregulation	NN
cord-296347-fanlvxqs	475	34	of	of	IN
cord-296347-fanlvxqs	475	35	class	class	NN
cord-296347-fanlvxqs	476	1	I	-PRON-	PRP
cord-296347-fanlvxqs	476	2	MHC	MHC	NNP
cord-296347-fanlvxqs	476	3	from	from	IN
cord-296347-fanlvxqs	476	4	the	the	DT
cord-296347-fanlvxqs	476	5	cell	cell	NN
cord-296347-fanlvxqs	476	6	surface	surface	NN
cord-296347-fanlvxqs	476	7	(	(	-LRB-
cord-296347-fanlvxqs	476	8	Furman	Furman	NNP
cord-296347-fanlvxqs	476	9	et	et	NNP
cord-296347-fanlvxqs	476	10	al	al	NNP
cord-296347-fanlvxqs	476	11	.	.	NNP
cord-296347-fanlvxqs	476	12	,	,	,
cord-296347-fanlvxqs	476	13	2002a	2002a	CD
cord-296347-fanlvxqs	476	14	)	)	-RRB-
cord-296347-fanlvxqs	476	15	.	.	.
cord-296347-fanlvxqs	477	1	US2	US2	NNP
cord-296347-fanlvxqs	477	2	and	and	CC
cord-296347-fanlvxqs	477	3	US11	US11	NNP
cord-296347-fanlvxqs	477	4	catalyze	catalyze	VB
cord-296347-fanlvxqs	477	5	destruction	destruction	NN
cord-296347-fanlvxqs	477	6	of	of	IN
cord-296347-fanlvxqs	477	7	class	class	NN
cord-296347-fanlvxqs	477	8	I	-PRON-	PRP
cord-296347-fanlvxqs	477	9	MHC	MHC	NNP
cord-296347-fanlvxqs	477	10	HCs	hc	NNS
cord-296347-fanlvxqs	477	11	from	from	IN
cord-296347-fanlvxqs	477	12	the	the	DT
cord-296347-fanlvxqs	477	13	ER	ER	NNP
cord-296347-fanlvxqs	477	14	membrane	membrane	NN
cord-296347-fanlvxqs	477	15	by	by	IN
cord-296347-fanlvxqs	477	16	targeting	target	VBG
cord-296347-fanlvxqs	477	17	them	-PRON-	PRP
cord-296347-fanlvxqs	477	18	to	to	IN
cord-296347-fanlvxqs	477	19	the	the	DT
cord-296347-fanlvxqs	477	20	Ub	Ub	NNP
cord-296347-fanlvxqs	477	21	-	-	HYPH
cord-296347-fanlvxqs	477	22	proteasome	proteasome	NN
cord-296347-fanlvxqs	477	23	system	system	NN
cord-296347-fanlvxqs	478	1	(	(	-LRB-
cord-296347-fanlvxqs	478	2	Wiertz	Wiertz	NNP
cord-296347-fanlvxqs	478	3	et	et	NNP
cord-296347-fanlvxqs	478	4	al	al	NNP
cord-296347-fanlvxqs	478	5	.	.	NNP
cord-296347-fanlvxqs	478	6	,	,	,
cord-296347-fanlvxqs	478	7	1996a	1996a	CD
cord-296347-fanlvxqs	478	8	,	,	,
cord-296347-fanlvxqs	478	9	b	b	LS
cord-296347-fanlvxqs	478	10	)	)	-RRB-
cord-296347-fanlvxqs	478	11	,	,	,
cord-296347-fanlvxqs	478	12	a	a	DT
cord-296347-fanlvxqs	478	13	process	process	NN
cord-296347-fanlvxqs	478	14	we	-PRON-	PRP
cord-296347-fanlvxqs	478	15	discuss	discuss	VBP
cord-296347-fanlvxqs	478	16	in	in	IN
cord-296347-fanlvxqs	478	17	detail	detail	NN
cord-296347-fanlvxqs	478	18	in	in	IN
cord-296347-fanlvxqs	478	19	a	a	DT
cord-296347-fanlvxqs	478	20	later	later	JJ
cord-296347-fanlvxqs	478	21	section	section	NN
cord-296347-fanlvxqs	478	22	.	.	.
cord-296347-fanlvxqs	479	1	Expression	expression	NN
cord-296347-fanlvxqs	479	2	of	of	IN
cord-296347-fanlvxqs	479	3	each	each	DT
cord-296347-fanlvxqs	479	4	individual	individual	JJ
cord-296347-fanlvxqs	479	5	immunoevasin	immunoevasin	NN
cord-296347-fanlvxqs	479	6	results	result	VBZ
cord-296347-fanlvxqs	479	7	in	in	IN
cord-296347-fanlvxqs	479	8	reduction	reduction	NN
cord-296347-fanlvxqs	479	9	of	of	IN
cord-296347-fanlvxqs	479	10	cell	cell	NN
cord-296347-fanlvxqs	479	11	surface	surface	NN
cord-296347-fanlvxqs	479	12	expression	expression	NN
cord-296347-fanlvxqs	479	13	of	of	IN
cord-296347-fanlvxqs	479	14	class	class	NN
cord-296347-fanlvxqs	479	15	I	-PRON-	PRP
cord-296347-fanlvxqs	479	16	MHC	MHC	NNP
cord-296347-fanlvxqs	479	17	peptide	peptide	NN
cord-296347-fanlvxqs	479	18	-	-	HYPH
cord-296347-fanlvxqs	479	19	loaded	load	VBN
cord-296347-fanlvxqs	479	20	complexes	complex	NNS
cord-296347-fanlvxqs	479	21	and	and	CC
cord-296347-fanlvxqs	479	22	evasion	evasion	NN
cord-296347-fanlvxqs	479	23	of	of	IN
cord-296347-fanlvxqs	479	24	CD8	CD8	NNP
cord-296347-fanlvxqs	479	25	þ	þ	NNP
cord-296347-fanlvxqs	479	26	T	T	NNP
cord-296347-fanlvxqs	479	27	cell	cell	NN
cord-296347-fanlvxqs	479	28	-	-	HYPH
cord-296347-fanlvxqs	479	29	mediated	mediate	VBN
cord-296347-fanlvxqs	479	30	lysis	lysis	NN
cord-296347-fanlvxqs	479	31	(	(	-LRB-
cord-296347-fanlvxqs	479	32	Ahn	Ahn	NNP
cord-296347-fanlvxqs	479	33	et	et	NNP
cord-296347-fanlvxqs	479	34	al	al	NNP
cord-296347-fanlvxqs	479	35	.	.	NNP
cord-296347-fanlvxqs	479	36	,	,	,
cord-296347-fanlvxqs	479	37	1996	1996	CD
cord-296347-fanlvxqs	479	38	;	;	:
cord-296347-fanlvxqs	479	39	Jones	Jones	NNP
cord-296347-fanlvxqs	479	40	et	et	NNP
cord-296347-fanlvxqs	479	41	al	al	NNP
cord-296347-fanlvxqs	479	42	.	.	NNP
cord-296347-fanlvxqs	479	43	,	,	,
cord-296347-fanlvxqs	479	44	1995	1995	CD
cord-296347-fanlvxqs	479	45	)	)	-RRB-
cord-296347-fanlvxqs	479	46	.	.	.
cord-296347-fanlvxqs	480	1	Besides	besides	IN
cord-296347-fanlvxqs	480	2	CD8	CD8	NNP
cord-296347-fanlvxqs	480	3	þ	þ	NNP
cord-296347-fanlvxqs	480	4	T	T	NNP
cord-296347-fanlvxqs	480	5	cell	cell	NN
cord-296347-fanlvxqs	480	6	recognition	recognition	NN
cord-296347-fanlvxqs	480	7	,	,	,
cord-296347-fanlvxqs	480	8	HCMV	HCMV	NNP
cord-296347-fanlvxqs	480	9	can	can	MD
cord-296347-fanlvxqs	480	10	frustrate	frustrate	VB
cord-296347-fanlvxqs	480	11	NK	NK	NNP
cord-296347-fanlvxqs	480	12	cell	cell	NN
cord-296347-fanlvxqs	480	13	recognition	recognition	NN
cord-296347-fanlvxqs	480	14	(	(	-LRB-
cord-296347-fanlvxqs	480	15	Orange	Orange	NNP
cord-296347-fanlvxqs	480	16	et	et	FW
cord-296347-fanlvxqs	480	17	al	al	NNP
cord-296347-fanlvxqs	480	18	.	.	NNP
cord-296347-fanlvxqs	480	19	,	,	,
cord-296347-fanlvxqs	480	20	2002	2002	CD
cord-296347-fanlvxqs	480	21	)	)	-RRB-
cord-296347-fanlvxqs	480	22	.	.	.
cord-296347-fanlvxqs	481	1	Protection	protection	NN
cord-296347-fanlvxqs	481	2	of	of	IN
cord-296347-fanlvxqs	481	3	HCMV	HCMV	NNP
cord-296347-fanlvxqs	481	4	from	from	IN
cord-296347-fanlvxqs	481	5	NK	NK	NNP
cord-296347-fanlvxqs	481	6	cell	cell	NN
cord-296347-fanlvxqs	481	7	-	-	HYPH
cord-296347-fanlvxqs	481	8	mediated	mediate	VBN
cord-296347-fanlvxqs	481	9	lysis	lysis	NN
cord-296347-fanlvxqs	481	10	can	can	MD
cord-296347-fanlvxqs	481	11	be	be	VB
cord-296347-fanlvxqs	481	12	mediated	mediate	VBN
cord-296347-fanlvxqs	481	13	by	by	IN
cord-296347-fanlvxqs	481	14	several	several	JJ
cord-296347-fanlvxqs	481	15	immunoevasins	immunoevasin	NNS
cord-296347-fanlvxqs	481	16	,	,	,
cord-296347-fanlvxqs	481	17	HCMV	HCMV	NNP
cord-296347-fanlvxqs	481	18	UL16	UL16	NNP
cord-296347-fanlvxqs	481	19	,	,	,
cord-296347-fanlvxqs	481	20	UL40	UL40	NNP
cord-296347-fanlvxqs	481	21	,	,	,
cord-296347-fanlvxqs	481	22	UL18	UL18	NNP
cord-296347-fanlvxqs	481	23	,	,	,
cord-296347-fanlvxqs	481	24	UL141	ul141	CD
cord-296347-fanlvxqs	481	25	,	,	,
cord-296347-fanlvxqs	481	26	UL142	UL142	NNP
cord-296347-fanlvxqs	481	27	,	,	,
cord-296347-fanlvxqs	481	28	and	and	CC
cord-296347-fanlvxqs	481	29	pp65	pp65	RB
cord-296347-fanlvxqs	482	1	(	(	-LRB-
cord-296347-fanlvxqs	482	2	Lodoen	Lodoen	NNP
cord-296347-fanlvxqs	482	3	and	and	CC
cord-296347-fanlvxqs	482	4	Lanier	Lanier	NNP
cord-296347-fanlvxqs	482	5	,	,	,
cord-296347-fanlvxqs	482	6	2005	2005	CD
cord-296347-fanlvxqs	482	7	;	;	:
cord-296347-fanlvxqs	482	8	Orange	Orange	NNP
cord-296347-fanlvxqs	482	9	et	et	NNP
cord-296347-fanlvxqs	482	10	al	al	NNP
cord-296347-fanlvxqs	482	11	.	.	NNP
cord-296347-fanlvxqs	482	12	,	,	,
cord-296347-fanlvxqs	482	13	2002	2002	CD
cord-296347-fanlvxqs	482	14	;	;	:
cord-296347-fanlvxqs	482	15	Rajagopalan	Rajagopalan	NNP
cord-296347-fanlvxqs	482	16	and	and	CC
cord-296347-fanlvxqs	482	17	Long	Long	NNP
cord-296347-fanlvxqs	482	18	,	,	,
cord-296347-fanlvxqs	482	19	2005	2005	CD
cord-296347-fanlvxqs	482	20	;	;	:
cord-296347-fanlvxqs	482	21	Reyburn	Reyburn	NNP
cord-296347-fanlvxqs	482	22	et	et	NNP
cord-296347-fanlvxqs	482	23	al	al	NNP
cord-296347-fanlvxqs	482	24	.	.	NNP
cord-296347-fanlvxqs	482	25	,	,	,
cord-296347-fanlvxqs	482	26	1997	1997	CD
cord-296347-fanlvxqs	482	27	;	;	:
cord-296347-fanlvxqs	482	28	Wills	Wills	NNPS
cord-296347-fanlvxqs	482	29	et	et	NNP
cord-296347-fanlvxqs	482	30	al	al	NNP
cord-296347-fanlvxqs	482	31	.	.	NNP
cord-296347-fanlvxqs	482	32	,	,	,
cord-296347-fanlvxqs	482	33	2005	2005	CD
cord-296347-fanlvxqs	482	34	)	)	-RRB-
cord-296347-fanlvxqs	482	35	.	.	.
cord-296347-fanlvxqs	483	1	The	the	DT
cord-296347-fanlvxqs	483	2	activating	activate	VBG
cord-296347-fanlvxqs	483	3	receptor	receptor	NN
cord-296347-fanlvxqs	483	4	NKG2D	NKG2D	NNS
cord-296347-fanlvxqs	483	5	on	on	IN
cord-296347-fanlvxqs	483	6	the	the	DT
cord-296347-fanlvxqs	483	7	NK	NK	NNP
cord-296347-fanlvxqs	483	8	cell	cell	NN
cord-296347-fanlvxqs	483	9	recognizes	recognize	VBZ
cord-296347-fanlvxqs	483	10	divergent	divergent	JJ
cord-296347-fanlvxqs	483	11	families	family	NNS
cord-296347-fanlvxqs	483	12	of	of	IN
cord-296347-fanlvxqs	483	13	class	class	NN
cord-296347-fanlvxqs	483	14	I	I	NNP
cord-296347-fanlvxqs	483	15	MHC	MHC	NNP
cord-296347-fanlvxqs	483	16	-	-	HYPH
cord-296347-fanlvxqs	483	17	related	relate	VBN
cord-296347-fanlvxqs	483	18	ligands	ligand	NNS
cord-296347-fanlvxqs	483	19	,	,	,
cord-296347-fanlvxqs	483	20	like	like	IN
cord-296347-fanlvxqs	483	21	the	the	DT
cord-296347-fanlvxqs	483	22	MIC	MIC	NNP
cord-296347-fanlvxqs	483	23	and	and	CC
cord-296347-fanlvxqs	483	24	ULBP	ulbp	JJ
cord-296347-fanlvxqs	483	25	products	product	NNS
cord-296347-fanlvxqs	483	26	.	.	.
cord-296347-fanlvxqs	484	1	HCMV	HCMV	NNP
cord-296347-fanlvxqs	484	2	UL16	UL16	NNP
cord-296347-fanlvxqs	484	3	retains	retain	VBZ
cord-296347-fanlvxqs	484	4	the	the	DT
cord-296347-fanlvxqs	484	5	ULBP	ULBP	NNP
cord-296347-fanlvxqs	484	6	1	1	CD
cord-296347-fanlvxqs	484	7	,	,	,
cord-296347-fanlvxqs	484	8	ULBP	ULBP	NNP
cord-296347-fanlvxqs	484	9	2	2	CD
cord-296347-fanlvxqs	484	10	,	,	,
cord-296347-fanlvxqs	484	11	and	and	CC
cord-296347-fanlvxqs	484	12	MIC	MIC	NNP
cord-296347-fanlvxqs	484	13	-	-	HYPH
cord-296347-fanlvxqs	484	14	B	b	NN
cord-296347-fanlvxqs	484	15	NKG2D	nkg2d	NN
cord-296347-fanlvxqs	484	16	ligands	ligand	NNS
cord-296347-fanlvxqs	484	17	in	in	IN
cord-296347-fanlvxqs	484	18	the	the	DT
cord-296347-fanlvxqs	484	19	ERGIC	ERGIC	NNP
cord-296347-fanlvxqs	484	20	compartment	compartment	NN
cord-296347-fanlvxqs	484	21	of	of	IN
cord-296347-fanlvxqs	484	22	the	the	DT
cord-296347-fanlvxqs	484	23	target	target	NN
cord-296347-fanlvxqs	484	24	cell	cell	NN
cord-296347-fanlvxqs	484	25	,	,	,
cord-296347-fanlvxqs	484	26	preventing	prevent	VBG
cord-296347-fanlvxqs	484	27	NKG2D	nkg2d	NN
cord-296347-fanlvxqs	484	28	recognition	recognition	NN
cord-296347-fanlvxqs	484	29	and	and	CC
cord-296347-fanlvxqs	484	30	thus	thus	RB
cord-296347-fanlvxqs	484	31	NK	NK	NNP
cord-296347-fanlvxqs	484	32	cell	cell	NN
cord-296347-fanlvxqs	484	33	activation	activation	NN
cord-296347-fanlvxqs	484	34	.	.	.
cord-296347-fanlvxqs	485	1	HCMV	HCMV	NNP
cord-296347-fanlvxqs	485	2	UL141	UL141	NNP
cord-296347-fanlvxqs	485	3	and	and	CC
cord-296347-fanlvxqs	485	4	pp65	pp65	RB
cord-296347-fanlvxqs	485	5	act	act	VB
cord-296347-fanlvxqs	485	6	at	at	IN
cord-296347-fanlvxqs	485	7	the	the	DT
cord-296347-fanlvxqs	485	8	level	level	NN
cord-296347-fanlvxqs	485	9	of	of	IN
cord-296347-fanlvxqs	485	10	the	the	DT
cord-296347-fanlvxqs	485	11	NK	NK	NNP
cord-296347-fanlvxqs	485	12	effector	effector	NN
cord-296347-fanlvxqs	485	13	cell	cell	NN
cord-296347-fanlvxqs	485	14	rather	rather	RB
cord-296347-fanlvxqs	485	15	than	than	IN
cord-296347-fanlvxqs	485	16	the	the	DT
cord-296347-fanlvxqs	485	17	APC	APC	NNP
cord-296347-fanlvxqs	485	18	.	.	.
cord-296347-fanlvxqs	486	1	The	the	DT
cord-296347-fanlvxqs	486	2	result	result	NN
cord-296347-fanlvxqs	486	3	is	be	VBZ
cord-296347-fanlvxqs	486	4	,	,	,
cord-296347-fanlvxqs	486	5	nevertheless	nevertheless	RB
cord-296347-fanlvxqs	486	6	,	,	,
cord-296347-fanlvxqs	486	7	the	the	DT
cord-296347-fanlvxqs	486	8	same	same	JJ
cord-296347-fanlvxqs	486	9	:	:	:
cord-296347-fanlvxqs	486	10	prevention	prevention	NN
cord-296347-fanlvxqs	486	11	of	of	IN
cord-296347-fanlvxqs	486	12	NK	NK	NNP
cord-296347-fanlvxqs	486	13	cell	cell	NN
cord-296347-fanlvxqs	486	14	activation	activation	NN
cord-296347-fanlvxqs	486	15	.	.	.
cord-296347-fanlvxqs	487	1	UL141	UL141	NNP
cord-296347-fanlvxqs	487	2	downregulates	downregulate	VBZ
cord-296347-fanlvxqs	487	3	the	the	DT
cord-296347-fanlvxqs	487	4	NK	NK	NNP
cord-296347-fanlvxqs	487	5	cell	cell	NN
cord-296347-fanlvxqs	487	6	-	-	HYPH
cord-296347-fanlvxqs	487	7	activating	activate	VBG
cord-296347-fanlvxqs	487	8	receptors	receptor	NNS
cord-296347-fanlvxqs	488	1	CD226	CD226	NNP
cord-296347-fanlvxqs	488	2	(	(	-LRB-
cord-296347-fanlvxqs	488	3	DNAM-1	DNAM-1	NNP
cord-296347-fanlvxqs	488	4	)	)	-RRB-
cord-296347-fanlvxqs	488	5	and	and	CC
cord-296347-fanlvxqs	488	6	CD96	CD96	NNP
cord-296347-fanlvxqs	488	7	(	(	-LRB-
cord-296347-fanlvxqs	488	8	TACTILE	TACTILE	NNP
cord-296347-fanlvxqs	488	9	)	)	-RRB-
cord-296347-fanlvxqs	488	10	.	.	.
cord-296347-fanlvxqs	489	1	The	the	DT
cord-296347-fanlvxqs	489	2	pp65	pp65	NNP
cord-296347-fanlvxqs	489	3	tegument	tegument	NN
cord-296347-fanlvxqs	489	4	protein	protein	NN
cord-296347-fanlvxqs	489	5	engages	engage	VBZ
cord-296347-fanlvxqs	489	6	the	the	DT
cord-296347-fanlvxqs	489	7	activating	activate	VBG
cord-296347-fanlvxqs	489	8	receptor	receptor	NN
cord-296347-fanlvxqs	489	9	NKp30	NKp30	NNS
cord-296347-fanlvxqs	489	10	and	and	CC
cord-296347-fanlvxqs	489	11	antagonizes	antagonize	VBZ
cord-296347-fanlvxqs	489	12	its	-PRON-	PRP$
cord-296347-fanlvxqs	489	13	effects	effect	NNS
cord-296347-fanlvxqs	489	14	,	,	,
cord-296347-fanlvxqs	489	15	dampening	dampen	VBG
cord-296347-fanlvxqs	489	16	NK	NK	NNP
cord-296347-fanlvxqs	489	17	cell	cell	NN
cord-296347-fanlvxqs	489	18	-	-	HYPH
cord-296347-fanlvxqs	489	19	mediated	mediate	VBN
cord-296347-fanlvxqs	489	20	cytotoxicity	cytotoxicity	NN
cord-296347-fanlvxqs	489	21	.	.	.
cord-296347-fanlvxqs	490	1	How	how	WRB
cord-296347-fanlvxqs	490	2	a	a	DT
cord-296347-fanlvxqs	490	3	tegument	tegument	NN
cord-296347-fanlvxqs	490	4	protein	protein	NN
cord-296347-fanlvxqs	490	5	gains	gain	VBZ
cord-296347-fanlvxqs	490	6	access	access	NN
cord-296347-fanlvxqs	490	7	to	to	IN
cord-296347-fanlvxqs	490	8	the	the	DT
cord-296347-fanlvxqs	490	9	receptor	receptor	NN
cord-296347-fanlvxqs	490	10	on	on	IN
cord-296347-fanlvxqs	490	11	the	the	DT
cord-296347-fanlvxqs	490	12	NK	NK	NNP
cord-296347-fanlvxqs	490	13	cell	cell	NN
cord-296347-fanlvxqs	490	14	is	be	VBZ
cord-296347-fanlvxqs	490	15	unknown	unknown	JJ
cord-296347-fanlvxqs	490	16	,	,	,
cord-296347-fanlvxqs	490	17	but	but	CC
cord-296347-fanlvxqs	490	18	pp65	pp65	RB
cord-296347-fanlvxqs	490	19	engagement	engagement	NN
cord-296347-fanlvxqs	490	20	of	of	IN
cord-296347-fanlvxqs	490	21	the	the	DT
cord-296347-fanlvxqs	490	22	NKp30	nkp30	JJ
cord-296347-fanlvxqs	490	23	receptor	receptor	NN
cord-296347-fanlvxqs	490	24	causes	cause	VBZ
cord-296347-fanlvxqs	490	25	dissociation	dissociation	NN
cord-296347-fanlvxqs	490	26	of	of	IN
cord-296347-fanlvxqs	490	27	a	a	DT
cord-296347-fanlvxqs	490	28	receptor	receptor	NN
cord-296347-fanlvxqs	490	29	-	-	HYPH
cord-296347-fanlvxqs	490	30	associated	associate	VBN
cord-296347-fanlvxqs	490	31	signaling	signaling	NN
cord-296347-fanlvxqs	490	32	module	module	NN
cord-296347-fanlvxqs	490	33	(	(	-LRB-
cord-296347-fanlvxqs	490	34	Orange	Orange	NNP
cord-296347-fanlvxqs	490	35	et	et	FW
cord-296347-fanlvxqs	490	36	al	al	NNP
cord-296347-fanlvxqs	490	37	.	.	NNP
cord-296347-fanlvxqs	490	38	,	,	,
cord-296347-fanlvxqs	490	39	2002	2002	CD
cord-296347-fanlvxqs	490	40	)	)	-RRB-
cord-296347-fanlvxqs	490	41	,	,	,
cord-296347-fanlvxqs	490	42	disrupting	disrupt	VBG
cord-296347-fanlvxqs	490	43	the	the	DT
cord-296347-fanlvxqs	490	44	activating	activate	VBG
cord-296347-fanlvxqs	490	45	signaling	signal	VBG
cord-296347-fanlvxqs	490	46	pathway	pathway	NN
cord-296347-fanlvxqs	490	47	that	that	WDT
cord-296347-fanlvxqs	490	48	would	would	MD
cord-296347-fanlvxqs	490	49	lead	lead	VB
cord-296347-fanlvxqs	490	50	to	to	IN
cord-296347-fanlvxqs	490	51	NK	NK	NNP
cord-296347-fanlvxqs	490	52	cell	cell	NN
cord-296347-fanlvxqs	490	53	activation	activation	NN
cord-296347-fanlvxqs	490	54	(	(	-LRB-
cord-296347-fanlvxqs	490	55	Arnon	Arnon	NNP
cord-296347-fanlvxqs	490	56	et	et	NNP
cord-296347-fanlvxqs	490	57	al	al	NNP
cord-296347-fanlvxqs	490	58	.	.	NNP
cord-296347-fanlvxqs	490	59	,	,	,
cord-296347-fanlvxqs	490	60	2005	2005	CD
cord-296347-fanlvxqs	490	61	)	)	-RRB-
cord-296347-fanlvxqs	490	62	.	.	.
cord-296347-fanlvxqs	491	1	NK	NK	NNP
cord-296347-fanlvxqs	491	2	cell	cell	NN
cord-296347-fanlvxqs	491	3	responses	response	NNS
cord-296347-fanlvxqs	491	4	also	also	RB
cord-296347-fanlvxqs	491	5	rely	rely	VBP
cord-296347-fanlvxqs	491	6	on	on	IN
cord-296347-fanlvxqs	491	7	receptors	receptor	NNS
cord-296347-fanlvxqs	491	8	that	that	WDT
cord-296347-fanlvxqs	491	9	recognize	recognize	VBP
cord-296347-fanlvxqs	491	10	class	class	NN
cord-296347-fanlvxqs	491	11	I	-PRON-	PRP
cord-296347-fanlvxqs	491	12	MHC	MHC	NNP
cord-296347-fanlvxqs	491	13	locus	locus	NN
cord-296347-fanlvxqs	491	14	products	product	NNS
cord-296347-fanlvxqs	491	15	.	.	.
cord-296347-fanlvxqs	492	1	The	the	DT
cord-296347-fanlvxqs	492	2	killer	killer	NN
cord-296347-fanlvxqs	492	3	cell	cell	NN
cord-296347-fanlvxqs	492	4	immunoglobulin	immunoglobulin	NN
cord-296347-fanlvxqs	492	5	-	-	HYPH
cord-296347-fanlvxqs	492	6	like	like	JJ
cord-296347-fanlvxqs	492	7	receptor	receptor	NN
cord-296347-fanlvxqs	492	8	(	(	-LRB-
cord-296347-fanlvxqs	492	9	KIR	KIR	NNP
cord-296347-fanlvxqs	492	10	)	)	-RRB-
cord-296347-fanlvxqs	492	11	genes	gene	NNS
cord-296347-fanlvxqs	492	12	encode	encode	VBP
cord-296347-fanlvxqs	492	13	a	a	DT
cord-296347-fanlvxqs	492	14	family	family	NN
cord-296347-fanlvxqs	492	15	of	of	IN
cord-296347-fanlvxqs	492	16	activating	activate	VBG
cord-296347-fanlvxqs	492	17	and	and	CC
cord-296347-fanlvxqs	492	18	inhibitory	inhibitory	JJ
cord-296347-fanlvxqs	492	19	receptors	receptor	NNS
cord-296347-fanlvxqs	492	20	that	that	WDT
cord-296347-fanlvxqs	492	21	recognize	recognize	VBP
cord-296347-fanlvxqs	492	22	human	human	JJ
cord-296347-fanlvxqs	492	23	leukocyte	leukocyte	NN
cord-296347-fanlvxqs	492	24	antigen	antigen	NN
cord-296347-fanlvxqs	492	25	(	(	-LRB-
cord-296347-fanlvxqs	492	26	HLA)-A	HLA)-A	NNP
cord-296347-fanlvxqs	492	27	,	,	,
cord-296347-fanlvxqs	492	28	-B	-b	ADD
cord-296347-fanlvxqs	492	29	,	,	,
cord-296347-fanlvxqs	492	30	and	and	CC
cord-296347-fanlvxqs	492	31	-C.	-c.	NN
cord-296347-fanlvxqs	493	1	The	the	DT
cord-296347-fanlvxqs	493	2	CD94	CD94	NNP
cord-296347-fanlvxqs	493	3	/	/	SYM
cord-296347-fanlvxqs	493	4	NKG2	NKG2	NNP
cord-296347-fanlvxqs	493	5	receptors	receptor	NNS
cord-296347-fanlvxqs	493	6	recognize	recognize	VBP
cord-296347-fanlvxqs	493	7	the	the	DT
cord-296347-fanlvxqs	493	8	nonclassical	nonclassical	JJ
cord-296347-fanlvxqs	493	9	class	class	NN
cord-296347-fanlvxqs	494	1	I	-PRON-	PRP
cord-296347-fanlvxqs	494	2	MHC	MHC	NNP
cord-296347-fanlvxqs	494	3	molecule	molecule	NN
cord-296347-fanlvxqs	495	1	HLA	HLA	NNP
cord-296347-fanlvxqs	495	2	-	-	HYPH
cord-296347-fanlvxqs	495	3	E.	E.	NNP
cord-296347-fanlvxqs	495	4	HLA	HLA	NNP
cord-296347-fanlvxqs	495	5	-	-	HYPH
cord-296347-fanlvxqs	495	6	E	E	NNP
cord-296347-fanlvxqs	495	7	presents	present	VBZ
cord-296347-fanlvxqs	495	8	fragments	fragment	NNS
cord-296347-fanlvxqs	495	9	derived	derive	VBN
cord-296347-fanlvxqs	495	10	from	from	IN
cord-296347-fanlvxqs	495	11	the	the	DT
cord-296347-fanlvxqs	495	12	signal	signal	NN
cord-296347-fanlvxqs	495	13	sequences	sequence	NNS
cord-296347-fanlvxqs	495	14	of	of	IN
cord-296347-fanlvxqs	495	15	classical	classical	JJ
cord-296347-fanlvxqs	495	16	class	class	NN
cord-296347-fanlvxqs	495	17	I	-PRON-	PRP
cord-296347-fanlvxqs	495	18	MHC	MHC	NNP
cord-296347-fanlvxqs	495	19	molecules	molecule	NNS
cord-296347-fanlvxqs	495	20	,	,	,
cord-296347-fanlvxqs	495	21	which	which	WDT
cord-296347-fanlvxqs	495	22	delivers	deliver	VBZ
cord-296347-fanlvxqs	495	23	an	an	DT
cord-296347-fanlvxqs	495	24	inhibitory	inhibitory	JJ
cord-296347-fanlvxqs	495	25	signal	signal	NN
cord-296347-fanlvxqs	495	26	to	to	IN
cord-296347-fanlvxqs	495	27	CD94	CD94	NNP
cord-296347-fanlvxqs	495	28	/	/	SYM
cord-296347-fanlvxqs	495	29	NKG2	NKG2	NNP
cord-296347-fanlvxqs	495	30	receptors	receptor	NNS
cord-296347-fanlvxqs	495	31	on	on	IN
cord-296347-fanlvxqs	495	32	NK	NK	NNP
cord-296347-fanlvxqs	495	33	cells	cell	NNS
cord-296347-fanlvxqs	495	34	.	.	.
cord-296347-fanlvxqs	496	1	UL40	UL40	NNP
cord-296347-fanlvxqs	496	2	encodes	encode	VBZ
cord-296347-fanlvxqs	496	3	a	a	DT
cord-296347-fanlvxqs	496	4	peptide	peptide	NN
cord-296347-fanlvxqs	496	5	whose	whose	WP$
cord-296347-fanlvxqs	496	6	sequence	sequence	NN
cord-296347-fanlvxqs	496	7	is	be	VBZ
cord-296347-fanlvxqs	496	8	exactly	exactly	RB
cord-296347-fanlvxqs	496	9	homologous	homologous	JJ
cord-296347-fanlvxqs	496	10	to	to	IN
cord-296347-fanlvxqs	496	11	the	the	DT
cord-296347-fanlvxqs	496	12	HLA	HLA	NNP
cord-296347-fanlvxqs	496	13	-	-	HYPH
cord-296347-fanlvxqs	496	14	E	e	NN
cord-296347-fanlvxqs	496	15	binding	binding	NN
cord-296347-fanlvxqs	496	16	leader	leader	NN
cord-296347-fanlvxqs	496	17	peptide	peptide	NN
cord-296347-fanlvxqs	496	18	from	from	IN
cord-296347-fanlvxqs	496	19	HLA	HLA	NNP
cord-296347-fanlvxqs	496	20	-	-	HYPH
cord-296347-fanlvxqs	496	21	C	C	NNP
cord-296347-fanlvxqs	496	22	locus	locus	NN
cord-296347-fanlvxqs	496	23	products	product	NNS
cord-296347-fanlvxqs	496	24	.	.	.
cord-296347-fanlvxqs	497	1	UL40	UL40	NNP
cord-296347-fanlvxqs	497	2	therefore	therefore	RB
cord-296347-fanlvxqs	497	3	loads	load	VBZ
cord-296347-fanlvxqs	497	4	HLA	HLA	NNP
cord-296347-fanlvxqs	497	5	-	-	HYPH
cord-296347-fanlvxqs	497	6	E	E	NNP
cord-296347-fanlvxqs	497	7	and	and	CC
cord-296347-fanlvxqs	497	8	maintains	maintain	VBZ
cord-296347-fanlvxqs	497	9	HLA	HLA	NNP
cord-296347-fanlvxqs	497	10	-	-	HYPH
cord-296347-fanlvxqs	497	11	E	E	NNP
cord-296347-fanlvxqs	497	12	on	on	IN
cord-296347-fanlvxqs	497	13	infected	infected	JJ
cord-296347-fanlvxqs	497	14	cells	cell	NNS
cord-296347-fanlvxqs	498	1	(	(	-LRB-
cord-296347-fanlvxqs	498	2	Tomasec	Tomasec	NNP
cord-296347-fanlvxqs	498	3	et	et	FW
cord-296347-fanlvxqs	498	4	al	al	NNP
cord-296347-fanlvxqs	498	5	.	.	NNP
cord-296347-fanlvxqs	498	6	,	,	,
cord-296347-fanlvxqs	498	7	2000	2000	CD
cord-296347-fanlvxqs	498	8	;	;	:
cord-296347-fanlvxqs	499	1	Ulbrecht	Ulbrecht	NNP
cord-296347-fanlvxqs	499	2	et	et	NNP
cord-296347-fanlvxqs	499	3	al	al	NNP
cord-296347-fanlvxqs	499	4	.	.	NNP
cord-296347-fanlvxqs	499	5	,	,	,
cord-296347-fanlvxqs	499	6	2000	2000	CD
cord-296347-fanlvxqs	499	7	)	)	-RRB-
cord-296347-fanlvxqs	499	8	even	even	RB
cord-296347-fanlvxqs	499	9	when	when	WRB
cord-296347-fanlvxqs	499	10	other	other	JJ
cord-296347-fanlvxqs	499	11	class	class	NN
cord-296347-fanlvxqs	499	12	I	-PRON-	PRP
cord-296347-fanlvxqs	499	13	MHC	MHC	NNP
cord-296347-fanlvxqs	499	14	products	product	NNS
cord-296347-fanlvxqs	499	15	are	be	VBP
cord-296347-fanlvxqs	499	16	downregulated	downregulate	VBN
cord-296347-fanlvxqs	499	17	.	.	.
cord-296347-fanlvxqs	500	1	UL18	UL18	NNP
cord-296347-fanlvxqs	500	2	encodes	encode	VBZ
cord-296347-fanlvxqs	500	3	a	a	DT
cord-296347-fanlvxqs	500	4	class	class	NN
cord-296347-fanlvxqs	500	5	I	-PRON-	PRP
cord-296347-fanlvxqs	500	6	MHC	MHC	NNP
cord-296347-fanlvxqs	500	7	-	-	HYPH
cord-296347-fanlvxqs	500	8	like	like	JJ
cord-296347-fanlvxqs	500	9	molecule	molecule	NN
cord-296347-fanlvxqs	500	10	that	that	WDT
cord-296347-fanlvxqs	500	11	engages	engage	VBZ
cord-296347-fanlvxqs	500	12	the	the	DT
cord-296347-fanlvxqs	500	13	inhibitory	inhibitory	JJ
cord-296347-fanlvxqs	500	14	CD85j	CD85j	NNP
cord-296347-fanlvxqs	500	15	/	/	SYM
cord-296347-fanlvxqs	500	16	LIR-1	LIR-1	NNP
cord-296347-fanlvxqs	500	17	/	/	SYM
cord-296347-fanlvxqs	500	18	ILT-2	ILT-2	NNP
cord-296347-fanlvxqs	500	19	receptor	receptor	NN
cord-296347-fanlvxqs	500	20	on	on	IN
cord-296347-fanlvxqs	500	21	the	the	DT
cord-296347-fanlvxqs	500	22	NK	NK	NNP
cord-296347-fanlvxqs	500	23	cell	cell	NN
cord-296347-fanlvxqs	500	24	,	,	,
cord-296347-fanlvxqs	500	25	thus	thus	RB
cord-296347-fanlvxqs	500	26	inhibiting	inhibit	VBG
cord-296347-fanlvxqs	500	27	NK	NK	NNP
cord-296347-fanlvxqs	500	28	cell	cell	NN
cord-296347-fanlvxqs	500	29	effector	effector	NN
cord-296347-fanlvxqs	500	30	functions	function	NNS
cord-296347-fanlvxqs	500	31	(	(	-LRB-
cord-296347-fanlvxqs	500	32	Cosman	Cosman	NNP
cord-296347-fanlvxqs	500	33	et	et	NNP
cord-296347-fanlvxqs	500	34	al	al	NNP
cord-296347-fanlvxqs	500	35	.	.	NNP
cord-296347-fanlvxqs	500	36	,	,	,
cord-296347-fanlvxqs	500	37	1997	1997	CD
cord-296347-fanlvxqs	500	38	;	;	:
cord-296347-fanlvxqs	500	39	Reyburn	Reyburn	NNP
cord-296347-fanlvxqs	500	40	et	et	NNP
cord-296347-fanlvxqs	500	41	al	al	NNP
cord-296347-fanlvxqs	500	42	.	.	NNP
cord-296347-fanlvxqs	500	43	,	,	,
cord-296347-fanlvxqs	500	44	1997	1997	CD
cord-296347-fanlvxqs	500	45	)	)	-RRB-
cord-296347-fanlvxqs	500	46	.	.	.
cord-296347-fanlvxqs	501	1	However	however	RB
cord-296347-fanlvxqs	501	2	,	,	,
cord-296347-fanlvxqs	501	3	UL18	UL18	NNP
cord-296347-fanlvxqs	501	4	and	and	CC
cord-296347-fanlvxqs	501	5	UL40	UL40	NNP
cord-296347-fanlvxqs	501	6	expression	expression	NN
cord-296347-fanlvxqs	501	7	may	may	MD
cord-296347-fanlvxqs	501	8	be	be	VB
cord-296347-fanlvxqs	501	9	insufficient	insufficient	JJ
cord-296347-fanlvxqs	501	10	to	to	TO
cord-296347-fanlvxqs	501	11	confer	confer	VB
cord-296347-fanlvxqs	501	12	target	target	NN
cord-296347-fanlvxqs	501	13	cell	cell	NN
cord-296347-fanlvxqs	501	14	protection	protection	NN
cord-296347-fanlvxqs	501	15	(	(	-LRB-
cord-296347-fanlvxqs	501	16	Falk	Falk	NNP
cord-296347-fanlvxqs	501	17	et	et	NNP
cord-296347-fanlvxqs	501	18	al	al	NNP
cord-296347-fanlvxqs	501	19	.	.	NNP
cord-296347-fanlvxqs	501	20	,	,	,
cord-296347-fanlvxqs	501	21	2002	2002	CD
cord-296347-fanlvxqs	501	22	;	;	:
cord-296347-fanlvxqs	501	23	Leong	Leong	NNP
cord-296347-fanlvxqs	501	24	et	et	NNP
cord-296347-fanlvxqs	501	25	al	al	NNP
cord-296347-fanlvxqs	501	26	.	.	NNP
cord-296347-fanlvxqs	501	27	,	,	,
cord-296347-fanlvxqs	501	28	1998	1998	CD
cord-296347-fanlvxqs	501	29	)	)	-RRB-
cord-296347-fanlvxqs	501	30	.	.	.
cord-296347-fanlvxqs	502	1	UL18	UL18	NNP
cord-296347-fanlvxqs	502	2	and	and	CC
cord-296347-fanlvxqs	502	3	UL40	UL40	NNP
cord-296347-fanlvxqs	502	4	may	may	MD
cord-296347-fanlvxqs	502	5	,	,	,
cord-296347-fanlvxqs	502	6	in	in	IN
cord-296347-fanlvxqs	502	7	fact	fact	NN
cord-296347-fanlvxqs	502	8	,	,	,
cord-296347-fanlvxqs	502	9	be	be	VB
cord-296347-fanlvxqs	502	10	more	more	RBR
cord-296347-fanlvxqs	502	11	relevant	relevant	JJ
cord-296347-fanlvxqs	502	12	for	for	IN
cord-296347-fanlvxqs	502	13	control	control	NN
cord-296347-fanlvxqs	502	14	of	of	IN
cord-296347-fanlvxqs	502	15	viral	viral	JJ
cord-296347-fanlvxqs	502	16	infection	infection	NN
cord-296347-fanlvxqs	502	17	by	by	IN
cord-296347-fanlvxqs	502	18	T	t	NN
cord-296347-fanlvxqs	502	19	cells	cell	NNS
cord-296347-fanlvxqs	502	20	,	,	,
cord-296347-fanlvxqs	502	21	with	with	IN
cord-296347-fanlvxqs	502	22	HLA	HLA	NNP
cord-296347-fanlvxqs	502	23	-	-	HYPH
cord-296347-fanlvxqs	502	24	E	e	NN
cord-296347-fanlvxqs	502	25	-	-	HYPH
cord-296347-fanlvxqs	502	26	restricted	restrict	VBN
cord-296347-fanlvxqs	502	27	CD8	CD8	NNP
cord-296347-fanlvxqs	502	28	þ	þ	NNP
cord-296347-fanlvxqs	502	29	T	t	NN
cord-296347-fanlvxqs	502	30	cells	cell	NNS
cord-296347-fanlvxqs	502	31	playing	play	VBG
cord-296347-fanlvxqs	502	32	a	a	DT
cord-296347-fanlvxqs	502	33	role	role	NN
cord-296347-fanlvxqs	502	34	in	in	IN
cord-296347-fanlvxqs	502	35	lysis	lysis	NN
cord-296347-fanlvxqs	502	36	of	of	IN
cord-296347-fanlvxqs	502	37	cells	cell	NNS
cord-296347-fanlvxqs	502	38	expressing	express	VBG
cord-296347-fanlvxqs	502	39	UL40	UL40	NNP
cord-296347-fanlvxqs	502	40	,	,	,
cord-296347-fanlvxqs	502	41	and	and	CC
cord-296347-fanlvxqs	502	42	non	non	JJ
cord-296347-fanlvxqs	502	43	-	-	JJ
cord-296347-fanlvxqs	502	44	MHCrestricted	mhcrestricted	JJ
cord-296347-fanlvxqs	502	45	CD8	CD8	NNP
cord-296347-fanlvxqs	502	46	þ	þ	NNP
cord-296347-fanlvxqs	502	47	T	T	NNP
cord-296347-fanlvxqs	502	48	cells	cell	NNS
cord-296347-fanlvxqs	502	49	playing	play	VBG
cord-296347-fanlvxqs	502	50	a	a	DT
cord-296347-fanlvxqs	502	51	role	role	NN
cord-296347-fanlvxqs	502	52	in	in	IN
cord-296347-fanlvxqs	502	53	lysis	lysis	NN
cord-296347-fanlvxqs	502	54	of	of	IN
cord-296347-fanlvxqs	502	55	UL18-positive	ul18-positive	JJ
cord-296347-fanlvxqs	502	56	cells	cell	NNS
cord-296347-fanlvxqs	502	57	(	(	-LRB-
cord-296347-fanlvxqs	502	58	Pietra	Pietra	NNP
cord-296347-fanlvxqs	502	59	et	et	FW
cord-296347-fanlvxqs	502	60	al	al	NNP
cord-296347-fanlvxqs	502	61	.	.	NNP
cord-296347-fanlvxqs	502	62	,	,	,
cord-296347-fanlvxqs	502	63	2003	2003	CD
cord-296347-fanlvxqs	502	64	;	;	:
cord-296347-fanlvxqs	503	1	Romagnani	Romagnani	NNP
cord-296347-fanlvxqs	503	2	et	et	NNP
cord-296347-fanlvxqs	503	3	al	al	NNP
cord-296347-fanlvxqs	503	4	.	.	NNP
cord-296347-fanlvxqs	503	5	,	,	,
cord-296347-fanlvxqs	503	6	2004	2004	CD
cord-296347-fanlvxqs	503	7	;	;	:
cord-296347-fanlvxqs	503	8	Saverino	Saverino	NNP
cord-296347-fanlvxqs	503	9	et	et	FW
cord-296347-fanlvxqs	503	10	al	al	NNP
cord-296347-fanlvxqs	503	11	.	.	NNP
cord-296347-fanlvxqs	503	12	,	,	,
cord-296347-fanlvxqs	503	13	2004	2004	CD
cord-296347-fanlvxqs	503	14	)	)	-RRB-
cord-296347-fanlvxqs	503	15	.	.	.
cord-296347-fanlvxqs	504	1	CD85j	CD85j	NNP
cord-296347-fanlvxqs	504	2	is	be	VBZ
cord-296347-fanlvxqs	504	3	an	an	DT
cord-296347-fanlvxqs	504	4	invariant	invariant	JJ
cord-296347-fanlvxqs	504	5	receptor	receptor	NN
cord-296347-fanlvxqs	504	6	expressed	express	VBN
cord-296347-fanlvxqs	504	7	by	by	IN
cord-296347-fanlvxqs	504	8	many	many	JJ
cord-296347-fanlvxqs	504	9	T	t	NN
cord-296347-fanlvxqs	504	10	cells	cell	NNS
cord-296347-fanlvxqs	504	11	and	and	CC
cord-296347-fanlvxqs	504	12	responsible	responsible	JJ
cord-296347-fanlvxqs	504	13	for	for	IN
cord-296347-fanlvxqs	504	14	transduction	transduction	NN
cord-296347-fanlvxqs	504	15	of	of	IN
cord-296347-fanlvxqs	504	16	inhibitory	inhibitory	JJ
cord-296347-fanlvxqs	504	17	signals	signal	NNS
cord-296347-fanlvxqs	504	18	that	that	WDT
cord-296347-fanlvxqs	504	19	downregulate	downregulate	VBP
cord-296347-fanlvxqs	504	20	antigen	antigen	NN
cord-296347-fanlvxqs	504	21	-	-	HYPH
cord-296347-fanlvxqs	504	22	specific	specific	JJ
cord-296347-fanlvxqs	504	23	T	t	NN
cord-296347-fanlvxqs	504	24	cell	cell	NN
cord-296347-fanlvxqs	504	25	functions	function	NNS
cord-296347-fanlvxqs	504	26	(	(	-LRB-
cord-296347-fanlvxqs	504	27	Merlo	Merlo	NNP
cord-296347-fanlvxqs	504	28	et	et	NNP
cord-296347-fanlvxqs	504	29	al	al	NNP
cord-296347-fanlvxqs	504	30	.	.	NNP
cord-296347-fanlvxqs	504	31	,	,	,
cord-296347-fanlvxqs	504	32	2001	2001	CD
cord-296347-fanlvxqs	504	33	;	;	:
cord-296347-fanlvxqs	504	34	Saverino	Saverino	NNP
cord-296347-fanlvxqs	504	35	et	et	NNP
cord-296347-fanlvxqs	504	36	al	al	NNP
cord-296347-fanlvxqs	504	37	.	.	NNP
cord-296347-fanlvxqs	504	38	,	,	,
cord-296347-fanlvxqs	504	39	2000	2000	CD
cord-296347-fanlvxqs	504	40	)	)	-RRB-
cord-296347-fanlvxqs	504	41	.	.	.
cord-296347-fanlvxqs	505	1	CD85j	CD85j	NNP
cord-296347-fanlvxqs	505	2	interaction	interaction	NN
cord-296347-fanlvxqs	505	3	with	with	IN
cord-296347-fanlvxqs	505	4	UL18	UL18	NNP
cord-296347-fanlvxqs	505	5	on	on	IN
cord-296347-fanlvxqs	505	6	CD8	CD8	NNP
cord-296347-fanlvxqs	505	7	þ	þ	NNP
cord-296347-fanlvxqs	505	8	T	T	NNP
cord-296347-fanlvxqs	505	9	cells	cell	NNS
cord-296347-fanlvxqs	505	10	occurs	occur	VBZ
cord-296347-fanlvxqs	505	11	in	in	IN
cord-296347-fanlvxqs	505	12	a	a	DT
cord-296347-fanlvxqs	505	13	TCR	TCR	NNP
cord-296347-fanlvxqs	505	14	-	-	HYPH
cord-296347-fanlvxqs	505	15	independent	independent	JJ
cord-296347-fanlvxqs	505	16	manner	manner	NN
cord-296347-fanlvxqs	505	17	and	and	CC
cord-296347-fanlvxqs	505	18	leads	lead	VBZ
cord-296347-fanlvxqs	505	19	to	to	TO
cord-296347-fanlvxqs	505	20	activation	activation	VB
cord-296347-fanlvxqs	505	21	(	(	-LRB-
cord-296347-fanlvxqs	505	22	not	not	RB
cord-296347-fanlvxqs	505	23	inhibition	inhibition	NN
cord-296347-fanlvxqs	505	24	)	)	-RRB-
cord-296347-fanlvxqs	505	25	of	of	IN
cord-296347-fanlvxqs	505	26	non	non	JJ
cord-296347-fanlvxqs	505	27	-	-	JJ
cord-296347-fanlvxqs	505	28	MHCrestricted	mhcrestricted	JJ
cord-296347-fanlvxqs	505	29	CD8	CD8	NNP
cord-296347-fanlvxqs	505	30	þ	þ	NNP
cord-296347-fanlvxqs	505	31	T	t	NN
cord-296347-fanlvxqs	505	32	cells	cell	NNS
cord-296347-fanlvxqs	505	33	(	(	-LRB-
cord-296347-fanlvxqs	505	34	Saverino	Saverino	NNP
cord-296347-fanlvxqs	505	35	et	et	FW
cord-296347-fanlvxqs	505	36	al	al	NNP
cord-296347-fanlvxqs	505	37	.	.	NNP
cord-296347-fanlvxqs	505	38	,	,	,
cord-296347-fanlvxqs	505	39	2004	2004	CD
cord-296347-fanlvxqs	505	40	)	)	-RRB-
cord-296347-fanlvxqs	505	41	.	.	.
cord-296347-fanlvxqs	506	1	This	this	DT
cord-296347-fanlvxqs	506	2	expands	expand	VBZ
cord-296347-fanlvxqs	506	3	the	the	DT
cord-296347-fanlvxqs	506	4	repertoire	repertoire	NN
cord-296347-fanlvxqs	506	5	of	of	IN
cord-296347-fanlvxqs	506	6	T	T	NNP
cord-296347-fanlvxqs	506	7	cell	cell	NN
cord-296347-fanlvxqs	506	8	activation	activation	NN
cord-296347-fanlvxqs	506	9	mechanisms	mechanism	NNS
cord-296347-fanlvxqs	506	10	and	and	CC
cord-296347-fanlvxqs	506	11	is	be	VBZ
cord-296347-fanlvxqs	506	12	probably	probably	RB
cord-296347-fanlvxqs	506	13	a	a	DT
cord-296347-fanlvxqs	506	14	viral	viral	JJ
cord-296347-fanlvxqs	506	15	strategy	strategy	NN
cord-296347-fanlvxqs	506	16	of	of	IN
cord-296347-fanlvxqs	506	17	ensuring	ensure	VBG
cord-296347-fanlvxqs	506	18	survival	survival	NN
cord-296347-fanlvxqs	506	19	of	of	IN
cord-296347-fanlvxqs	506	20	the	the	DT
cord-296347-fanlvxqs	506	21	host	host	NN
cord-296347-fanlvxqs	506	22	,	,	,
cord-296347-fanlvxqs	506	23	by	by	IN
cord-296347-fanlvxqs	506	24	allowing	allow	VBG
cord-296347-fanlvxqs	506	25	some	some	DT
cord-296347-fanlvxqs	506	26	level	level	NN
cord-296347-fanlvxqs	506	27	of	of	IN
cord-296347-fanlvxqs	506	28	protection	protection	NN
cord-296347-fanlvxqs	506	29	from	from	IN
cord-296347-fanlvxqs	506	30	the	the	DT
cord-296347-fanlvxqs	506	31	initial	initial	JJ
cord-296347-fanlvxqs	506	32	wave	wave	NN
cord-296347-fanlvxqs	506	33	of	of	IN
cord-296347-fanlvxqs	506	34	NK	NK	NNP
cord-296347-fanlvxqs	506	35	cellmediated	cellmediate	VBN
cord-296347-fanlvxqs	506	36	antiviral	antiviral	JJ
cord-296347-fanlvxqs	506	37	response	response	NN
cord-296347-fanlvxqs	506	38	.	.	.
cord-296347-fanlvxqs	507	1	In	in	IN
cord-296347-fanlvxqs	507	2	vivo	vivo	NNP
cord-296347-fanlvxqs	507	3	HCMV	HCMV	NNP
cord-296347-fanlvxqs	507	4	-	-	HYPH
cord-296347-fanlvxqs	507	5	infected	infect	VBN
cord-296347-fanlvxqs	507	6	APCs	apc	NNS
cord-296347-fanlvxqs	507	7	are	be	VBP
cord-296347-fanlvxqs	507	8	faced	face	VBN
cord-296347-fanlvxqs	507	9	with	with	IN
cord-296347-fanlvxqs	507	10	multiple	multiple	JJ
cord-296347-fanlvxqs	507	11	immunoevasins	immunoevasin	NNS
cord-296347-fanlvxqs	507	12	displaying	display	VBG
cord-296347-fanlvxqs	507	13	allelic	allelic	JJ
cord-296347-fanlvxqs	507	14	preferences	preference	NNS
cord-296347-fanlvxqs	507	15	and	and	CC
cord-296347-fanlvxqs	507	16	expression	expression	NN
cord-296347-fanlvxqs	507	17	patterns	pattern	NNS
cord-296347-fanlvxqs	507	18	that	that	WDT
cord-296347-fanlvxqs	507	19	are	be	VBP
cord-296347-fanlvxqs	507	20	both	both	DT
cord-296347-fanlvxqs	507	21	spatially	spatially	RB
cord-296347-fanlvxqs	507	22	and	and	CC
cord-296347-fanlvxqs	507	23	temporally	temporally	RB
cord-296347-fanlvxqs	507	24	regulated	regulate	VBN
cord-296347-fanlvxqs	507	25	.	.	.
cord-296347-fanlvxqs	508	1	The	the	DT
cord-296347-fanlvxqs	508	2	many	many	JJ
cord-296347-fanlvxqs	508	3	immunoevasins	immunoevasin	NNS
cord-296347-fanlvxqs	508	4	expressed	express	VBN
cord-296347-fanlvxqs	508	5	by	by	IN
cord-296347-fanlvxqs	508	6	HCMV	HCMV	NNP
cord-296347-fanlvxqs	508	7	are	be	VBP
cord-296347-fanlvxqs	508	8	thus	thus	RB
cord-296347-fanlvxqs	508	9	likely	likely	JJ
cord-296347-fanlvxqs	508	10	to	to	TO
cord-296347-fanlvxqs	508	11	have	have	VB
cord-296347-fanlvxqs	508	12	both	both	DT
cord-296347-fanlvxqs	508	13	synergistic	synergistic	JJ
cord-296347-fanlvxqs	508	14	and	and	CC
cord-296347-fanlvxqs	508	15	antagonistic	antagonistic	JJ
cord-296347-fanlvxqs	508	16	interactions	interaction	NNS
cord-296347-fanlvxqs	508	17	(	(	-LRB-
cord-296347-fanlvxqs	508	18	Ahn	Ahn	NNP
cord-296347-fanlvxqs	508	19	et	et	NNP
cord-296347-fanlvxqs	508	20	al	al	NNP
cord-296347-fanlvxqs	508	21	.	.	.
cord-296347-fanlvxqs	509	1	,	,	,
cord-296347-fanlvxqs	509	2	1996	1996	CD
cord-296347-fanlvxqs	509	3	;	;	:
cord-296347-fanlvxqs	509	4	Farrell	Farrell	NNP
cord-296347-fanlvxqs	509	5	et	et	NNP
cord-296347-fanlvxqs	509	6	al	al	NNP
cord-296347-fanlvxqs	509	7	.	.	NNP
cord-296347-fanlvxqs	509	8	,	,	,
cord-296347-fanlvxqs	509	9	2000	2000	CD
cord-296347-fanlvxqs	509	10	;	;	:
cord-296347-fanlvxqs	510	1	Klenerman	Klenerman	NNP
cord-296347-fanlvxqs	510	2	and	and	CC
cord-296347-fanlvxqs	510	3	Hill	Hill	NNP
cord-296347-fanlvxqs	510	4	,	,	,
cord-296347-fanlvxqs	510	5	2005	2005	CD
cord-296347-fanlvxqs	510	6	;	;	:
cord-296347-fanlvxqs	510	7	Mocarski	Mocarski	NNP
cord-296347-fanlvxqs	510	8	,	,	,
cord-296347-fanlvxqs	510	9	2004	2004	CD
cord-296347-fanlvxqs	510	10	;	;	:
cord-296347-fanlvxqs	510	11	Reddehase	Reddehase	NNP
cord-296347-fanlvxqs	510	12	,	,	,
cord-296347-fanlvxqs	510	13	2002	2002	CD
cord-296347-fanlvxqs	510	14	;	;	:
cord-296347-fanlvxqs	510	15	Yewdell	Yewdell	NNP
cord-296347-fanlvxqs	510	16	and	and	CC
cord-296347-fanlvxqs	510	17	Hill	Hill	NNP
cord-296347-fanlvxqs	510	18	,	,	,
cord-296347-fanlvxqs	510	19	2002	2002	CD
cord-296347-fanlvxqs	510	20	)	)	-RRB-
cord-296347-fanlvxqs	510	21	,	,	,
cord-296347-fanlvxqs	510	22	as	as	IN
cord-296347-fanlvxqs	510	23	has	have	VBZ
cord-296347-fanlvxqs	510	24	been	be	VBN
cord-296347-fanlvxqs	510	25	experimentally	experimentally	RB
cord-296347-fanlvxqs	510	26	verified	verify	VBN
cord-296347-fanlvxqs	510	27	for	for	IN
cord-296347-fanlvxqs	510	28	murine	murine	JJ
cord-296347-fanlvxqs	510	29	cytomegalovirus	cytomegalovirus	NN
cord-296347-fanlvxqs	510	30	(	(	-LRB-
cord-296347-fanlvxqs	510	31	Wagner	Wagner	NNP
cord-296347-fanlvxqs	510	32	et	et	NNP
cord-296347-fanlvxqs	510	33	al	al	NNP
cord-296347-fanlvxqs	510	34	.	.	NNP
cord-296347-fanlvxqs	510	35	,	,	,
cord-296347-fanlvxqs	510	36	2002	2002	CD
cord-296347-fanlvxqs	510	37	)	)	-RRB-
cord-296347-fanlvxqs	510	38	.	.	.
cord-296347-fanlvxqs	511	1	Evidence	evidence	NN
cord-296347-fanlvxqs	511	2	of	of	IN
cord-296347-fanlvxqs	511	3	ER	ER	NNP
cord-296347-fanlvxqs	511	4	-	-	HYPH
cord-296347-fanlvxqs	511	5	to	to	IN
cord-296347-fanlvxqs	511	6	-	-	HYPH
cord-296347-fanlvxqs	511	7	cytosol	cytosol	NN
cord-296347-fanlvxqs	511	8	transport	transport	NN
cord-296347-fanlvxqs	511	9	or	or	CC
cord-296347-fanlvxqs	511	10	dislocation	dislocation	NN
cord-296347-fanlvxqs	511	11	,	,	,
cord-296347-fanlvxqs	511	12	a	a	DT
cord-296347-fanlvxqs	511	13	crucial	crucial	JJ
cord-296347-fanlvxqs	511	14	ER	ER	NNP
cord-296347-fanlvxqs	511	15	quality	quality	NN
cord-296347-fanlvxqs	511	16	control	control	NN
cord-296347-fanlvxqs	511	17	step	step	NN
cord-296347-fanlvxqs	511	18	now	now	RB
cord-296347-fanlvxqs	511	19	considered	consider	VBN
cord-296347-fanlvxqs	511	20	of	of	IN
cord-296347-fanlvxqs	511	21	general	general	JJ
cord-296347-fanlvxqs	511	22	importance	importance	NN
cord-296347-fanlvxqs	511	23	in	in	IN
cord-296347-fanlvxqs	511	24	dispensing	dispense	VBG
cord-296347-fanlvxqs	511	25	with	with	IN
cord-296347-fanlvxqs	511	26	misfolded	misfolded	JJ
cord-296347-fanlvxqs	511	27	or	or	CC
cord-296347-fanlvxqs	511	28	misassembled	misassembled	JJ
cord-296347-fanlvxqs	511	29	ER	er	NN
cord-296347-fanlvxqs	511	30	proteins	protein	NNS
cord-296347-fanlvxqs	511	31	,	,	,
cord-296347-fanlvxqs	511	32	was	be	VBD
cord-296347-fanlvxqs	511	33	initially	initially	RB
cord-296347-fanlvxqs	511	34	provided	provide	VBN
cord-296347-fanlvxqs	511	35	by	by	IN
cord-296347-fanlvxqs	511	36	studying	study	VBG
cord-296347-fanlvxqs	511	37	the	the	DT
cord-296347-fanlvxqs	511	38	mechanism	mechanism	NN
cord-296347-fanlvxqs	511	39	of	of	IN
cord-296347-fanlvxqs	511	40	action	action	NN
cord-296347-fanlvxqs	511	41	of	of	IN
cord-296347-fanlvxqs	511	42	the	the	DT
cord-296347-fanlvxqs	511	43	HCMV	HCMV	NNP
cord-296347-fanlvxqs	511	44	US2	US2	NNP
cord-296347-fanlvxqs	511	45	and	and	CC
cord-296347-fanlvxqs	511	46	US11	US11	NNP
cord-296347-fanlvxqs	511	47	immunoevasins	immunoevasins	NNP
cord-296347-fanlvxqs	512	1	(	(	-LRB-
cord-296347-fanlvxqs	512	2	Wiertz	Wiertz	NNP
cord-296347-fanlvxqs	512	3	et	et	NNP
cord-296347-fanlvxqs	512	4	al	al	NNP
cord-296347-fanlvxqs	512	5	.	.	.
cord-296347-fanlvxqs	513	1	,	,	,
cord-296347-fanlvxqs	513	2	1996a	1996a	CD
cord-296347-fanlvxqs	513	3	,	,	,
cord-296347-fanlvxqs	513	4	b	b	LS
cord-296347-fanlvxqs	513	5	)	)	-RRB-
cord-296347-fanlvxqs	513	6	.	.	.
cord-296347-fanlvxqs	514	1	The	the	DT
cord-296347-fanlvxqs	514	2	viral	viral	JJ
cord-296347-fanlvxqs	514	3	proteins	protein	NNS
cord-296347-fanlvxqs	514	4	appropriate	appropriate	VBP
cord-296347-fanlvxqs	514	5	this	this	DT
cord-296347-fanlvxqs	514	6	cellular	cellular	JJ
cord-296347-fanlvxqs	514	7	quality	quality	NN
cord-296347-fanlvxqs	514	8	control	control	NN
cord-296347-fanlvxqs	514	9	process	process	NN
cord-296347-fanlvxqs	514	10	to	to	TO
cord-296347-fanlvxqs	514	11	extract	extract	VB
cord-296347-fanlvxqs	514	12	(	(	-LRB-
cord-296347-fanlvxqs	514	13	dislocate	dislocate	VB
cord-296347-fanlvxqs	514	14	)	)	-RRB-
cord-296347-fanlvxqs	514	15	class	class	NN
cord-296347-fanlvxqs	514	16	I	-PRON-	PRP
cord-296347-fanlvxqs	514	17	MHC	MHC	NNP
cord-296347-fanlvxqs	514	18	HCs	hc	NNS
cord-296347-fanlvxqs	514	19	from	from	IN
cord-296347-fanlvxqs	514	20	the	the	DT
cord-296347-fanlvxqs	514	21	ER	ER	NNP
cord-296347-fanlvxqs	514	22	membrane	membrane	NN
cord-296347-fanlvxqs	514	23	.	.	.
cord-296347-fanlvxqs	515	1	On	on	IN
cord-296347-fanlvxqs	515	2	arrival	arrival	NN
cord-296347-fanlvxqs	515	3	in	in	IN
cord-296347-fanlvxqs	515	4	the	the	DT
cord-296347-fanlvxqs	515	5	cytoplasm	cytoplasm	NN
cord-296347-fanlvxqs	515	6	,	,	,
cord-296347-fanlvxqs	515	7	the	the	DT
cord-296347-fanlvxqs	515	8	dislocated	dislocate	VBN
cord-296347-fanlvxqs	515	9	HC	HC	NNP
cord-296347-fanlvxqs	515	10	molecules	molecule	NNS
cord-296347-fanlvxqs	515	11	are	be	VBP
cord-296347-fanlvxqs	515	12	destroyed	destroy	VBN
cord-296347-fanlvxqs	515	13	by	by	IN
cord-296347-fanlvxqs	515	14	the	the	DT
cord-296347-fanlvxqs	515	15	proteasome	proteasome	NN
cord-296347-fanlvxqs	515	16	;	;	:
cord-296347-fanlvxqs	515	17	destruction	destruction	NN
cord-296347-fanlvxqs	515	18	of	of	IN
cord-296347-fanlvxqs	515	19	the	the	DT
cord-296347-fanlvxqs	515	20	HC	HC	NNP
cord-296347-fanlvxqs	515	21	component	component	NN
cord-296347-fanlvxqs	515	22	of	of	IN
cord-296347-fanlvxqs	515	23	the	the	DT
cord-296347-fanlvxqs	515	24	class	class	NN
cord-296347-fanlvxqs	515	25	I	-PRON-	PRP
cord-296347-fanlvxqs	515	26	MHC	MHC	NNP
cord-296347-fanlvxqs	515	27	complex	complex	NN
cord-296347-fanlvxqs	515	28	by	by	IN
cord-296347-fanlvxqs	515	29	US2	US2	NNP
cord-296347-fanlvxqs	515	30	and	and	CC
cord-296347-fanlvxqs	515	31	US11	US11	NNP
cord-296347-fanlvxqs	515	32	abolishes	abolish	VBZ
cord-296347-fanlvxqs	515	33	cell	cell	NN
cord-296347-fanlvxqs	515	34	-	-	HYPH
cord-296347-fanlvxqs	515	35	surface	surface	NN
cord-296347-fanlvxqs	515	36	expression	expression	NN
cord-296347-fanlvxqs	515	37	of	of	IN
cord-296347-fanlvxqs	515	38	class	class	NN
cord-296347-fanlvxqs	515	39	I	-PRON-	PRP
cord-296347-fanlvxqs	515	40	MHC	MHC	NNP
cord-296347-fanlvxqs	515	41	complexes	complex	NNS
cord-296347-fanlvxqs	515	42	and	and	CC
cord-296347-fanlvxqs	515	43	,	,	,
cord-296347-fanlvxqs	515	44	consequently	consequently	RB
cord-296347-fanlvxqs	515	45	,	,	,
cord-296347-fanlvxqs	515	46	presentation	presentation	NN
cord-296347-fanlvxqs	515	47	of	of	IN
cord-296347-fanlvxqs	515	48	viral	viral	JJ
cord-296347-fanlvxqs	515	49	peptides	peptide	NNS
cord-296347-fanlvxqs	515	50	to	to	IN
cord-296347-fanlvxqs	515	51	CD8	CD8	NNP
cord-296347-fanlvxqs	515	52	þ	þ	NNP
cord-296347-fanlvxqs	515	53	T	T	NNP
cord-296347-fanlvxqs	515	54	cells	cell	NNS
cord-296347-fanlvxqs	515	55	,	,	,
cord-296347-fanlvxqs	515	56	allowing	allow	VBG
cord-296347-fanlvxqs	515	57	HCMV	HCMV	NNP
cord-296347-fanlvxqs	515	58	to	to	TO
cord-296347-fanlvxqs	515	59	remain	remain	VB
cord-296347-fanlvxqs	515	60	undetected	undetected	JJ
cord-296347-fanlvxqs	516	1	(	(	-LRB-
cord-296347-fanlvxqs	516	2	Wiertz	Wiertz	NNP
cord-296347-fanlvxqs	516	3	et	et	NNP
cord-296347-fanlvxqs	516	4	al	al	NNP
cord-296347-fanlvxqs	516	5	.	.	.
cord-296347-fanlvxqs	517	1	,	,	,
cord-296347-fanlvxqs	517	2	1996a	1996a	CD
cord-296347-fanlvxqs	517	3	,	,	,
cord-296347-fanlvxqs	517	4	b	b	LS
cord-296347-fanlvxqs	517	5	)	)	-RRB-
cord-296347-fanlvxqs	517	6	.	.	.
cord-296347-fanlvxqs	518	1	US2-and	US2-and	NNP
cord-296347-fanlvxqs	518	2	US11-mediated	us11-mediated	CD
cord-296347-fanlvxqs	518	3	HC	HC	NNP
cord-296347-fanlvxqs	518	4	dislocation	dislocation	NN
cord-296347-fanlvxqs	518	5	from	from	IN
cord-296347-fanlvxqs	518	6	the	the	DT
cord-296347-fanlvxqs	518	7	ER	ER	NNP
cord-296347-fanlvxqs	518	8	membrane	membrane	NN
cord-296347-fanlvxqs	518	9	is	be	VBZ
cord-296347-fanlvxqs	518	10	not	not	RB
cord-296347-fanlvxqs	518	11	only	only	RB
cord-296347-fanlvxqs	518	12	an	an	DT
cord-296347-fanlvxqs	518	13	ingenious	ingenious	JJ
cord-296347-fanlvxqs	518	14	viral	viral	JJ
cord-296347-fanlvxqs	518	15	immune	immune	JJ
cord-296347-fanlvxqs	518	16	evasion	evasion	NN
cord-296347-fanlvxqs	518	17	strategy	strategy	NN
cord-296347-fanlvxqs	518	18	,	,	,
cord-296347-fanlvxqs	518	19	but	but	CC
cord-296347-fanlvxqs	518	20	also	also	RB
cord-296347-fanlvxqs	518	21	a	a	DT
cord-296347-fanlvxqs	518	22	useful	useful	JJ
cord-296347-fanlvxqs	518	23	case	case	NN
cord-296347-fanlvxqs	518	24	study	study	NN
cord-296347-fanlvxqs	518	25	in	in	IN
cord-296347-fanlvxqs	518	26	ER	ER	NNP
cord-296347-fanlvxqs	518	27	quality	quality	NN
cord-296347-fanlvxqs	518	28	control	control	NN
cord-296347-fanlvxqs	518	29	and	and	CC
cord-296347-fanlvxqs	518	30	degradation	degradation	NN
cord-296347-fanlvxqs	518	31	.	.	.
cord-296347-fanlvxqs	519	1	One	one	CD
cord-296347-fanlvxqs	519	2	theme	theme	NN
cord-296347-fanlvxqs	519	3	that	that	WDT
cord-296347-fanlvxqs	519	4	arises	arise	VBZ
cord-296347-fanlvxqs	519	5	from	from	IN
cord-296347-fanlvxqs	519	6	the	the	DT
cord-296347-fanlvxqs	519	7	characterization	characterization	NN
cord-296347-fanlvxqs	519	8	of	of	IN
cord-296347-fanlvxqs	519	9	this	this	DT
cord-296347-fanlvxqs	519	10	process	process	NN
cord-296347-fanlvxqs	519	11	over	over	IN
cord-296347-fanlvxqs	519	12	the	the	DT
cord-296347-fanlvxqs	519	13	10	10	CD
cord-296347-fanlvxqs	519	14	years	year	NNS
cord-296347-fanlvxqs	519	15	that	that	WDT
cord-296347-fanlvxqs	519	16	have	have	VBP
cord-296347-fanlvxqs	519	17	passed	pass	VBN
cord-296347-fanlvxqs	519	18	since	since	IN
cord-296347-fanlvxqs	519	19	its	-PRON-	PRP$
cord-296347-fanlvxqs	519	20	discovery	discovery	NN
cord-296347-fanlvxqs	519	21	is	be	VBZ
cord-296347-fanlvxqs	519	22	that	that	IN
cord-296347-fanlvxqs	519	23	HC	HC	NNP
cord-296347-fanlvxqs	519	24	dislocation	dislocation	NN
cord-296347-fanlvxqs	519	25	is	be	VBZ
cord-296347-fanlvxqs	519	26	unique	unique	JJ
cord-296347-fanlvxqs	519	27	in	in	IN
cord-296347-fanlvxqs	519	28	many	many	JJ
cord-296347-fanlvxqs	519	29	respects	respect	NNS
cord-296347-fanlvxqs	519	30	:	:	:
cord-296347-fanlvxqs	519	31	HC	HC	NNP
cord-296347-fanlvxqs	519	32	molecules	molecule	NNS
cord-296347-fanlvxqs	519	33	do	do	VBP
cord-296347-fanlvxqs	519	34	not	not	RB
cord-296347-fanlvxqs	519	35	meet	meet	VB
cord-296347-fanlvxqs	519	36	the	the	DT
cord-296347-fanlvxqs	519	37	requirement	requirement	NN
cord-296347-fanlvxqs	519	38	of	of	IN
cord-296347-fanlvxqs	519	39	being	be	VBG
cord-296347-fanlvxqs	519	40	either	either	CC
cord-296347-fanlvxqs	519	41	misfolded	misfolde	VBN
cord-296347-fanlvxqs	519	42	or	or	CC
cord-296347-fanlvxqs	519	43	misassembled	misassembled	JJ
cord-296347-fanlvxqs	519	44	,	,	,
cord-296347-fanlvxqs	519	45	yet	yet	CC
cord-296347-fanlvxqs	519	46	their	-PRON-	PRP$
cord-296347-fanlvxqs	519	47	dislocation	dislocation	NN
cord-296347-fanlvxqs	519	48	takes	take	VBZ
cord-296347-fanlvxqs	519	49	place	place	NN
cord-296347-fanlvxqs	519	50	by	by	IN
cord-296347-fanlvxqs	519	51	virtue	virtue	NN
cord-296347-fanlvxqs	519	52	of	of	IN
cord-296347-fanlvxqs	519	53	the	the	DT
cord-296347-fanlvxqs	519	54	presence	presence	NN
cord-296347-fanlvxqs	519	55	of	of	IN
cord-296347-fanlvxqs	519	56	US2	US2	NNP
cord-296347-fanlvxqs	519	57	or	or	CC
cord-296347-fanlvxqs	519	58	US11	US11	NNP
cord-296347-fanlvxqs	519	59	;	;	:
cord-296347-fanlvxqs	519	60	the	the	DT
cord-296347-fanlvxqs	519	61	speed	speed	NN
cord-296347-fanlvxqs	519	62	of	of	IN
cord-296347-fanlvxqs	519	63	HC	HC	NNP
cord-296347-fanlvxqs	519	64	degradation	degradation	NN
cord-296347-fanlvxqs	519	65	is	be	VBZ
cord-296347-fanlvxqs	519	66	unrivaled	unrivale	VBN
cord-296347-fanlvxqs	519	67	by	by	IN
cord-296347-fanlvxqs	519	68	that	that	DT
cord-296347-fanlvxqs	519	69	of	of	IN
cord-296347-fanlvxqs	519	70	any	any	DT
cord-296347-fanlvxqs	519	71	other	other	JJ
cord-296347-fanlvxqs	519	72	ER	ER	NNP
cord-296347-fanlvxqs	519	73	-	-	HYPH
cord-296347-fanlvxqs	519	74	associated	associate	VBN
cord-296347-fanlvxqs	519	75	degradation	degradation	NN
cord-296347-fanlvxqs	519	76	substrates	substrate	NNS
cord-296347-fanlvxqs	519	77	:	:	:
cord-296347-fanlvxqs	520	1	HC	HC	NNP
cord-296347-fanlvxqs	520	2	half	half	JJ
cord-296347-fanlvxqs	520	3	-	-	HYPH
cord-296347-fanlvxqs	520	4	life	life	NN
cord-296347-fanlvxqs	520	5	is	be	VBZ
cord-296347-fanlvxqs	520	6	reduced	reduce	VBN
cord-296347-fanlvxqs	520	7	from	from	IN
cord-296347-fanlvxqs	520	8	hours	hour	NNS
cord-296347-fanlvxqs	520	9	to	to	IN
cord-296347-fanlvxqs	520	10	a	a	DT
cord-296347-fanlvxqs	520	11	mere	mere	JJ
cord-296347-fanlvxqs	520	12	2	2	CD
cord-296347-fanlvxqs	520	13	-	-	SYM
cord-296347-fanlvxqs	520	14	5	5	CD
cord-296347-fanlvxqs	520	15	min	min	NN
cord-296347-fanlvxqs	520	16	in	in	IN
cord-296347-fanlvxqs	520	17	cells	cell	NNS
cord-296347-fanlvxqs	520	18	infected	infect	VBN
cord-296347-fanlvxqs	520	19	by	by	IN
cord-296347-fanlvxqs	520	20	HCMV	HCMV	NNP
cord-296347-fanlvxqs	520	21	or	or	CC
cord-296347-fanlvxqs	520	22	in	in	IN
cord-296347-fanlvxqs	521	1	ce	ce	NNP
cord-296347-fanlvxqs	521	2	lls	lls	NNP
cord-296347-fanlvxqs	521	3	expressin	expressin	NNP
cord-296347-fanlvxqs	522	1	g	g	NNP
cord-296347-fanlvxqs	523	1	either	either	CC
cord-296347-fanlvxqs	523	2	US2	US2	NNP
cord-296347-fanlvxqs	523	3	or	or	CC
cord-296347-fanlvxqs	524	1	US11	US11	NNP
cord-296347-fanlvxqs	524	2	(	(	-LRB-
cord-296347-fanlvxqs	524	3	Wiertz	Wiertz	NNP
cord-296347-fanlvxqs	524	4	et	et	NNP
cord-296347-fanlvxqs	524	5	al	al	NNP
cord-296347-fanlvxqs	524	6	.	.	NNP
cord-296347-fanlvxqs	524	7	,	,	,
cord-296347-fanlvxqs	524	8	1996a	1996a	CD
cord-296347-fanlvxqs	524	9	,	,	,
cord-296347-fanlvxqs	524	10	b	b	LS
cord-296347-fanlvxqs	524	11	)	)	-RRB-
cord-296347-fanlvxqs	524	12	;	;	:
cord-296347-fanlvxqs	524	13	both	both	DT
cord-296347-fanlvxqs	524	14	US2	US2	NNP
cord-296347-fanlvxqs	524	15	and	and	CC
cord-296347-fanlvxqs	524	16	US11	US11	NNP
cord-296347-fanlvxqs	524	17	have	have	VBP
cord-296347-fanlvxqs	524	18	stringent	stringent	JJ
cord-296347-fanlvxqs	524	19	requirements	requirement	NNS
cord-296347-fanlvxqs	524	20	in	in	IN
cord-296347-fanlvxqs	524	21	terms	term	NNS
cord-296347-fanlvxqs	524	22	of	of	IN
cord-296347-fanlvxqs	524	23	which	which	WDT
cord-296347-fanlvxqs	524	24	HLA	HLA	NNP
cord-296347-fanlvxqs	524	25	alleles	allele	NNS
cord-296347-fanlvxqs	524	26	(	(	-LRB-
cord-296347-fanlvxqs	524	27	Barel	Barel	NNP
cord-296347-fanlvxqs	524	28	et	et	NNP
cord-296347-fanlvxqs	524	29	al	al	NNP
cord-296347-fanlvxqs	524	30	.	.	NNP
cord-296347-fanlvxqs	524	31	,	,	,
cord-296347-fanlvxqs	524	32	2003	2003	CD
cord-296347-fanlvxqs	524	33	(	(	-LRB-
cord-296347-fanlvxqs	524	34	Barel	Barel	NNP
cord-296347-fanlvxqs	524	35	et	et	NNP
cord-296347-fanlvxqs	524	36	al	al	NNP
cord-296347-fanlvxqs	524	37	.	.	NNP
cord-296347-fanlvxqs	524	38	,	,	,
cord-296347-fanlvxqs	524	39	,	,	,
cord-296347-fanlvxqs	524	40	2006	2006	CD
cord-296347-fanlvxqs	524	41	Machold	Machold	NNP
cord-296347-fanlvxqs	524	42	et	et	NNP
cord-296347-fanlvxqs	524	43	al	al	NNP
cord-296347-fanlvxqs	524	44	.	.	NNP
cord-296347-fanlvxqs	524	45	,	,	,
cord-296347-fanlvxqs	524	46	1997	1997	CD
cord-296347-fanlvxqs	524	47	)	)	-RRB-
cord-296347-fanlvxqs	524	48	or	or	CC
cord-296347-fanlvxqs	524	49	assembly	assembly	NN
cord-296347-fanlvxqs	524	50	,	,	,
cord-296347-fanlvxqs	524	51	folding	folding	NN
cord-296347-fanlvxqs	524	52	and	and	CC
cord-296347-fanlvxqs	524	53	ubiquitination	ubiquitination	NN
cord-296347-fanlvxqs	524	54	status	status	NN
cord-296347-fanlvxqs	524	55	of	of	IN
cord-296347-fanlvxqs	524	56	the	the	DT
cord-296347-fanlvxqs	524	57	class	class	NN
cord-296347-fanlvxqs	524	58	I	-PRON-	PRP
cord-296347-fanlvxqs	524	59	MHC	MHC	NNP
cord-296347-fanlvxqs	524	60	complex	complex	JJ
cord-296347-fanlvxqs	525	1	(	(	-LRB-
cord-296347-fanlvxqs	525	2	Blom	Blom	NNP
cord-296347-fanlvxqs	525	3	et	et	FW
cord-296347-fanlvxqs	525	4	al	al	NNP
cord-296347-fanlvxqs	525	5	.	.	NNP
cord-296347-fanlvxqs	525	6	,	,	,
cord-296347-fanlvxqs	525	7	2004	2004	CD
cord-296347-fanlvxqs	525	8	;	;	:
cord-296347-fanlvxqs	525	9	Furman	Furman	NNP
cord-296347-fanlvxqs	525	10	et	et	NNP
cord-296347-fanlvxqs	525	11	al	al	NNP
cord-296347-fanlvxqs	525	12	.	.	NNP
cord-296347-fanlvxqs	525	13	,	,	,
cord-296347-fanlvxqs	525	14	2003	2003	CD
cord-296347-fanlvxqs	526	1	;	;	:
cord-296347-fanlvxqs	526	2	Gewurz	Gewurz	NNP
cord-296347-fanlvxqs	526	3	et	et	NNP
cord-296347-fanlvxqs	526	4	al	al	NNP
cord-296347-fanlvxqs	526	5	.	.	.
cord-296347-fanlvxqs	527	1	,	,	,
cord-296347-fanlvxqs	527	2	2001	2001	CD
cord-296347-fanlvxqs	527	3	)	)	-RRB-
cord-296347-fanlvxqs	527	4	either	either	CC
cord-296347-fanlvxqs	527	5	viral	viral	JJ
cord-296347-fanlvxqs	527	6	protein	protein	NN
cord-296347-fanlvxqs	527	7	is	be	VBZ
cord-296347-fanlvxqs	527	8	able	able	JJ
cord-296347-fanlvxqs	527	9	to	to	TO
cord-296347-fanlvxqs	527	10	target	target	VB
cord-296347-fanlvxqs	527	11	for	for	IN
cord-296347-fanlvxqs	527	12	dislocation	dislocation	NN
cord-296347-fanlvxqs	527	13	and	and	CC
cord-296347-fanlvxqs	527	14	proteasomal	proteasomal	JJ
cord-296347-fanlvxqs	527	15	destruction	destruction	NN
cord-296347-fanlvxqs	527	16	.	.	.
cord-296347-fanlvxqs	528	1	Notwithstanding	notwithstanding	IN
cord-296347-fanlvxqs	528	2	the	the	DT
cord-296347-fanlvxqs	528	3	unique	unique	JJ
cord-296347-fanlvxqs	528	4	nature	nature	NN
cord-296347-fanlvxqs	528	5	of	of	IN
cord-296347-fanlvxqs	528	6	this	this	DT
cord-296347-fanlvxqs	528	7	virus	virus	NN
cord-296347-fanlvxqs	528	8	-	-	HYPH
cord-296347-fanlvxqs	528	9	mediated	mediate	VBN
cord-296347-fanlvxqs	528	10	process	process	NN
cord-296347-fanlvxqs	528	11	,	,	,
cord-296347-fanlvxqs	528	12	knowledge	knowledge	NN
cord-296347-fanlvxqs	528	13	from	from	IN
cord-296347-fanlvxqs	528	14	the	the	DT
cord-296347-fanlvxqs	528	15	US11	US11	NNP
cord-296347-fanlvxqs	528	16	pathway	pathway	NN
cord-296347-fanlvxqs	528	17	,	,	,
cord-296347-fanlvxqs	528	18	and	and	CC
cord-296347-fanlvxqs	528	19	in	in	IN
cord-296347-fanlvxqs	528	20	particular	particular	JJ
cord-296347-fanlvxqs	528	21	the	the	DT
cord-296347-fanlvxqs	528	22	identification	identification	NN
cord-296347-fanlvxqs	528	23	of	of	IN
cord-296347-fanlvxqs	528	24	the	the	DT
cord-296347-fanlvxqs	528	25	Derlin	Derlin	NNP
cord-296347-fanlvxqs	528	26	proteins	protein	NNS
cord-296347-fanlvxqs	528	27	,	,	,
cord-296347-fanlvxqs	528	28	has	have	VBZ
cord-296347-fanlvxqs	528	29	widened	widen	VBN
cord-296347-fanlvxqs	528	30	our	-PRON-	PRP$
cord-296347-fanlvxqs	528	31	understanding	understanding	NN
cord-296347-fanlvxqs	528	32	of	of	IN
cord-296347-fanlvxqs	528	33	the	the	DT
cord-296347-fanlvxqs	528	34	cellular	cellular	JJ
cord-296347-fanlvxqs	528	35	factors	factor	NNS
cord-296347-fanlvxqs	528	36	involved	involve	VBN
cord-296347-fanlvxqs	528	37	in	in	IN
cord-296347-fanlvxqs	528	38	ER	ER	NNP
cord-296347-fanlvxqs	528	39	dislocation	dislocation	NN
cord-296347-fanlvxqs	528	40	more	more	RBR
cord-296347-fanlvxqs	528	41	generally	generally	RB
cord-296347-fanlvxqs	528	42	Ploegh	Ploegh	NNP
cord-296347-fanlvxqs	528	43	,	,	,
cord-296347-fanlvxqs	528	44	2004	2004	CD
cord-296347-fanlvxqs	528	45	,	,	,
cord-296347-fanlvxqs	528	46	2005a	2005a	CD
cord-296347-fanlvxqs	528	47	)	)	-RRB-
cord-296347-fanlvxqs	528	48	.	.	.
cord-296347-fanlvxqs	529	1	The	the	DT
cord-296347-fanlvxqs	529	2	US11	US11	NNP
cord-296347-fanlvxqs	529	3	transmembrane	transmembrane	NN
cord-296347-fanlvxqs	529	4	domain	domain	NN
cord-296347-fanlvxqs	529	5	(	(	-LRB-
cord-296347-fanlvxqs	529	6	TMD	TMD	NNP
cord-296347-fanlvxqs	529	7	)	)	-RRB-
cord-296347-fanlvxqs	529	8	is	be	VBZ
cord-296347-fanlvxqs	529	9	crucial	crucial	JJ
cord-296347-fanlvxqs	529	10	for	for	IN
cord-296347-fanlvxqs	529	11	US11	US11	NNP
cord-296347-fanlvxqs	529	12	function	function	NN
cord-296347-fanlvxqs	529	13	:	:	:
cord-296347-fanlvxqs	529	14	more	more	RBR
cord-296347-fanlvxqs	529	15	specifically	specifically	RB
cord-296347-fanlvxqs	529	16	,	,	,
cord-296347-fanlvxqs	529	17	mutation	mutation	NN
cord-296347-fanlvxqs	529	18	of	of	IN
cord-296347-fanlvxqs	529	19	a	a	DT
cord-296347-fanlvxqs	529	20	polar	polar	JJ
cord-296347-fanlvxqs	529	21	amino	amino	NN
cord-296347-fanlvxqs	529	22	acid	acid	NN
cord-296347-fanlvxqs	529	23	,	,	,
cord-296347-fanlvxqs	529	24	glutamine	glutamine	NN
cord-296347-fanlvxqs	529	25	(	(	-LRB-
cord-296347-fanlvxqs	529	26	Q	Q	NNP
cord-296347-fanlvxqs	529	27	)	)	-RRB-
cord-296347-fanlvxqs	529	28	192	192	CD
cord-296347-fanlvxqs	529	29	,	,	,
cord-296347-fanlvxqs	529	30	within	within	IN
cord-296347-fanlvxqs	529	31	the	the	DT
cord-296347-fanlvxqs	529	32	US11	US11	NNP
cord-296347-fanlvxqs	529	33	TMD	TMD	NNP
cord-296347-fanlvxqs	529	34	to	to	IN
cord-296347-fanlvxqs	529	35	a	a	DT
cord-296347-fanlvxqs	529	36	hydrophobic	hydrophobic	JJ
cord-296347-fanlvxqs	529	37	leucine	leucine	NN
cord-296347-fanlvxqs	530	1	(	(	-LRB-
cord-296347-fanlvxqs	530	2	L	l	NN
cord-296347-fanlvxqs	530	3	)	)	-RRB-
cord-296347-fanlvxqs	530	4	residue	residue	NN
cord-296347-fanlvxqs	530	5	renders	render	VBZ
cord-296347-fanlvxqs	530	6	this	this	DT
cord-296347-fanlvxqs	530	7	US11	US11	NNP
cord-296347-fanlvxqs	530	8	Q192L	Q192L	NNP
cord-296347-fanlvxqs	530	9	mutant	mutant	NN
cord-296347-fanlvxqs	530	10	inactive	inactive	JJ
cord-296347-fanlvxqs	530	11	in	in	IN
cord-296347-fanlvxqs	530	12	dislocating	dislocate	VBG
cord-296347-fanlvxqs	530	13	HCs	hc	NNS
cord-296347-fanlvxqs	530	14	from	from	IN
cord-296347-fanlvxqs	530	15	the	the	DT
cord-296347-fanlvxqs	530	16	ER	ER	NNP
cord-296347-fanlvxqs	530	17	membrane	membrane	NN
cord-296347-fanlvxqs	530	18	.	.	.
cord-296347-fanlvxqs	531	1	In	in	IN
cord-296347-fanlvxqs	531	2	a	a	DT
cord-296347-fanlvxqs	531	3	screen	screen	NN
cord-296347-fanlvxqs	531	4	for	for	IN
cord-296347-fanlvxqs	531	5	proteins	protein	NNS
cord-296347-fanlvxqs	531	6	that	that	WDT
cord-296347-fanlvxqs	531	7	interact	interact	VBP
cord-296347-fanlvxqs	531	8	specifically	specifically	RB
cord-296347-fanlvxqs	531	9	with	with	IN
cord-296347-fanlvxqs	531	10	the	the	DT
cord-296347-fanlvxqs	531	11	active	active	JJ
cord-296347-fanlvxqs	531	12	version	version	NN
cord-296347-fanlvxqs	531	13	of	of	IN
cord-296347-fanlvxqs	531	14	US11	US11	NNP
cord-296347-fanlvxqs	531	15	,	,	,
cord-296347-fanlvxqs	531	16	work	work	VB
cord-296347-fanlvxqs	531	17	from	from	IN
cord-296347-fanlvxqs	531	18	our	-PRON-	PRP$
cord-296347-fanlvxqs	531	19	laboratory	laboratory	NN
cord-296347-fanlvxqs	531	20	showed	show	VBD
cord-296347-fanlvxqs	531	21	that	that	IN
cord-296347-fanlvxqs	531	22	the	the	DT
cord-296347-fanlvxqs	531	23	aforementioned	aforementioned	JJ
cord-296347-fanlvxqs	531	24	Derlins	Derlins	NNP
cord-296347-fanlvxqs	531	25	,	,	,
cord-296347-fanlvxqs	531	26	the	the	DT
cord-296347-fanlvxqs	531	27	mammalian	mammalian	JJ
cord-296347-fanlvxqs	531	28	Der1p	Der1p	NNP
cord-296347-fanlvxqs	531	29	homologues	homologue	NNS
cord-296347-fanlvxqs	531	30	,	,	,
cord-296347-fanlvxqs	531	31	are	be	VBP
cord-296347-fanlvxqs	531	32	involved	involve	VBN
cord-296347-fanlvxqs	531	33	in	in	IN
cord-296347-fanlvxqs	531	34	HC	HC	NNP
cord-296347-fanlvxqs	531	35	dislocation	dislocation	NN
cord-296347-fanlvxqs	531	36	mediated	mediate	VBN
cord-296347-fanlvxqs	531	37	by	by	IN
cord-296347-fanlvxqs	531	38	US11	US11	NNP
cord-296347-fanlvxqs	531	39	,	,	,
cord-296347-fanlvxqs	531	40	but	but	CC
cord-296347-fanlvxqs	531	41	not	not	RB
cord-296347-fanlvxqs	531	42	by	by	IN
cord-296347-fanlvxqs	531	43	US2	US2	NNP
cord-296347-fanlvxqs	531	44	(	(	-LRB-
cord-296347-fanlvxqs	531	45	Lilley	Lilley	NNP
cord-296347-fanlvxqs	531	46	and	and	CC
cord-296347-fanlvxqs	531	47	Ploegh	Ploegh	NNP
cord-296347-fanlvxqs	531	48	,	,	,
cord-296347-fanlvxqs	531	49	2004	2004	CD
cord-296347-fanlvxqs	531	50	)	)	-RRB-
cord-296347-fanlvxqs	531	51	.	.	.
cord-296347-fanlvxqs	532	1	The	the	DT
cord-296347-fanlvxqs	532	2	fact	fact	NN
cord-296347-fanlvxqs	532	3	that	that	IN
cord-296347-fanlvxqs	532	4	the	the	DT
cord-296347-fanlvxqs	532	5	dislocation	dislocation	NN
cord-296347-fanlvxqs	532	6	mechanism	mechanism	NN
cord-296347-fanlvxqs	532	7	used	use	VBN
cord-296347-fanlvxqs	532	8	by	by	IN
cord-296347-fanlvxqs	532	9	US2	US2	NNP
cord-296347-fanlvxqs	532	10	is	be	VBZ
cord-296347-fanlvxqs	532	11	not	not	RB
cord-296347-fanlvxqs	532	12	dependent	dependent	JJ
cord-296347-fanlvxqs	532	13	on	on	IN
cord-296347-fanlvxqs	532	14	the	the	DT
cord-296347-fanlvxqs	532	15	Derlins	Derlins	NNP
cord-296347-fanlvxqs	532	16	prompted	prompt	VBD
cord-296347-fanlvxqs	532	17	us	-PRON-	PRP
cord-296347-fanlvxqs	532	18	to	to	TO
cord-296347-fanlvxqs	532	19	investigate	investigate	VB
cord-296347-fanlvxqs	532	20	what	what	WP
cord-296347-fanlvxqs	532	21	other	other	JJ
cord-296347-fanlvxqs	532	22	ERAD	ERAD	NNP
cord-296347-fanlvxqs	532	23	pathw	pathw	NNP
cord-296347-fanlvxqs	532	24	ay	ay	UH
cord-296347-fanlvxqs	532	25	is	be	VBZ
cord-296347-fanlvxqs	532	26	being	be	VBG
cord-296347-fanlvxqs	532	27	coopted	coopte	VBN
cord-296347-fanlvxqs	532	28	by	by	IN
cord-296347-fanlvxqs	532	29	the	the	DT
cord-296347-fanlvxqs	532	30	HCMV	HCMV	NNP
cord-296347-fanlvxqs	532	31	US2	US2	NNP
cord-296347-fanlvxqs	532	32	immu	immu	NNP
cord-296347-fanlvxqs	532	33	noevasin	noevasin	NNP
cord-296347-fanlvxqs	532	34	and	and	CC
cord-296347-fanlvxqs	532	35	allow	allow	VB
cord-296347-fanlvxqs	532	36	ed	ed	NNP
cord-296347-fanlvxqs	532	37	us	-PRON-	PRP
cord-296347-fanlvxqs	532	38	to	to	TO
cord-296347-fanlvxqs	532	39	unco	unco	NNP
cord-296347-fanlvxqs	532	40	ver	ver	NNP
cord-296347-fanlvxqs	532	41	an	an	DT
cord-296347-fanlvxqs	532	42	unexpect	unexpect	JJ
cord-296347-fanlvxqs	532	43	ed	ed	FW
cord-296347-fanlvxqs	532	44	ERA	era	NN
cord-296347-fanlvxqs	532	45	D	d	NN
cord-296347-fanlvxqs	532	46	pl	pl	NN
cord-296347-fanlvxqs	532	47	ayer	ayer	NN
cord-296347-fanlvxqs	532	48	.	.	.
cord-296347-fanlvxqs	533	1	US2	US2	NNP
cord-296347-fanlvxqs	533	2	is	be	VBZ
cord-296347-fanlvxqs	533	3	an	an	DT
cord-296347-fanlvxqs	533	4	ER	ER	NNP
cord-296347-fanlvxqs	533	5	-	-	HYPH
cord-296347-fanlvxqs	533	6	resident	resident	NN
cord-296347-fanlvxqs	533	7	type	type	NN
cord-296347-fanlvxqs	533	8	I	-PRON-	PRP
cord-296347-fanlvxqs	533	9	membrane	membrane	VBP
cord-296347-fanlvxqs	533	10	glycoprotein	glycoprotein	NN
cord-296347-fanlvxqs	533	11	of	of	IN
cord-296347-fanlvxqs	533	12	only	only	RB
cord-296347-fanlvxqs	533	13	199	199	CD
cord-296347-fanlvxqs	533	14	amino	amino	JJ
cord-296347-fanlvxqs	533	15	acids	acid	NNS
cord-296347-fanlvxqs	533	16	,	,	,
cord-296347-fanlvxqs	533	17	with	with	IN
cord-296347-fanlvxqs	533	18	a	a	DT
cord-296347-fanlvxqs	533	19	noncleavable	noncleavable	JJ
cord-296347-fanlvxqs	533	20	signal	signal	NN
cord-296347-fanlvxqs	533	21	sequence	sequence	NN
cord-296347-fanlvxqs	533	22	(	(	-LRB-
cord-296347-fanlvxqs	533	23	Gewurz	Gewurz	NNP
cord-296347-fanlvxqs	533	24	et	et	NNP
cord-296347-fanlvxqs	533	25	a	a	DT
cord-296347-fanlvxqs	533	26	l.	l.	NN
cord-296347-fanlvxqs	533	27	,	,	,
cord-296347-fanlvxqs	533	28	2002	2002	CD
cord-296347-fanlvxqs	533	29	)	)	-RRB-
cord-296347-fanlvxqs	533	30	,	,	,
cord-296347-fanlvxqs	533	31	a	a	DT
cord-296347-fanlvxqs	533	32	lumenal	lumenal	JJ
cord-296347-fanlvxqs	533	33	domain	domain	NN
cord-296347-fanlvxqs	533	34	that	that	WDT
cord-296347-fanlvxqs	533	35	dictates	dictate	VBZ
cord-296347-fanlvxqs	533	36	an	an	DT
cord-296347-fanlvxqs	533	37	allele	allele	NN
cord-296347-fanlvxqs	533	38	-	-	HYPH
cord-296347-fanlvxqs	533	39	specific	specific	JJ
cord-296347-fanlvxqs	533	40	association	association	NN
cord-296347-fanlvxqs	533	41	with	with	IN
cord-296347-fanlvxqs	533	42	the	the	DT
cord-296347-fanlvxqs	533	43	lumenal	lumenal	JJ
cord-296347-fanlvxqs	533	44	domain	domain	NN
cord-296347-fanlvxqs	533	45	of	of	IN
cord-296347-fanlvxqs	533	46	HC	HC	NNP
cord-296347-fanlvxqs	533	47	(	(	-LRB-
cord-296347-fanlvxqs	533	48	Gewurz	Gewurz	NNP
cord-296347-fanlvxqs	533	49	et	et	NNP
cord-296347-fanlvxqs	533	50	al	al	NNP
cord-296347-fanlvxqs	533	51	.	.	NNP
cord-296347-fanlvxqs	533	52	,	,	,
cord-296347-fanlvxqs	533	53	2001	2001	CD
cord-296347-fanlvxqs	533	54	)	)	-RRB-
cord-296347-fanlvxqs	533	55	,	,	,
cord-296347-fanlvxqs	533	56	a	a	DT
cord-296347-fanlvxqs	533	57	transmembrane	transmembrane	NN
cord-296347-fanlvxqs	533	58	segment	segment	NN
cord-296347-fanlvxqs	533	59	,	,	,
cord-296347-fanlvxqs	533	60	and	and	CC
cord-296347-fanlvxqs	533	61	a	a	DT
cord-296347-fanlvxqs	533	62	short	short	JJ
cord-296347-fanlvxqs	533	63	cytosolic	cytosolic	JJ
cord-296347-fanlvxqs	533	64	tail	tail	NN
cord-296347-fanlvxqs	533	65	of	of	IN
cord-296347-fanlvxqs	533	66	only	only	RB
cord-296347-fanlvxqs	533	67	14	14	CD
cord-296347-fanlvxqs	533	68	amino	amino	JJ
cord-296347-fanlvxqs	533	69	acids	acid	NNS
cord-296347-fanlvxqs	533	70	(	(	-LRB-
cord-296347-fanlvxqs	533	71	residues	residue	NNS
cord-296347-fanlvxqs	533	72	185	185	CD
cord-296347-fanlvxqs	533	73	-	-	SYM
cord-296347-fanlvxqs	533	74	199	199	CD
cord-296347-fanlvxqs	533	75	)	)	-RRB-
cord-296347-fanlvxqs	533	76	,	,	,
cord-296347-fanlvxqs	533	77	with	with	IN
cord-296347-fanlvxqs	533	78	no	no	DT
cord-296347-fanlvxqs	533	79	obvious	obvious	JJ
cord-296347-fanlvxqs	533	80	sequence	sequence	NN
cord-296347-fanlvxqs	533	81	homology	homology	NN
cord-296347-fanlvxqs	533	82	to	to	IN
cord-296347-fanlvxqs	533	83	known	know	VBN
cord-296347-fanlvxqs	533	84	cellular	cellular	JJ
cord-296347-fanlvxqs	533	85	proteins	protein	NNS
cord-296347-fanlvxqs	533	86	.	.	.
cord-296347-fanlvxqs	534	1	The	the	DT
cord-296347-fanlvxqs	534	2	US2	US2	NNP
cord-296347-fanlvxqs	534	3	tail	tail	NN
cord-296347-fanlvxqs	534	4	is	be	VBZ
cord-296347-fanlvxqs	534	5	essential	essential	JJ
cord-296347-fanlvxqs	534	6	for	for	IN
cord-296347-fanlvxqs	534	7	dislocation	dislocation	NN
cord-296347-fanlvxqs	534	8	:	:	:
cord-296347-fanlvxqs	534	9	US2	US2	NNP
cord-296347-fanlvxqs	534	10	186	186	CD
cord-296347-fanlvxqs	534	11	,	,	,
cord-296347-fanlvxqs	534	12	a	a	DT
cord-296347-fanlvxqs	534	13	cytosolic	cytosolic	JJ
cord-296347-fanlvxqs	534	14	tail	tail	NN
cord-296347-fanlvxqs	534	15	deletion	deletion	NN
cord-296347-fanlvxqs	534	16	mutant	mutant	NN
cord-296347-fanlvxqs	534	17	of	of	IN
cord-296347-fanlvxqs	534	18	US2	US2	NNP
cord-296347-fanlvxqs	534	19	,	,	,
cord-296347-fanlvxqs	534	20	is	be	VBZ
cord-296347-fanlvxqs	534	21	dislocation	dislocation	NN
cord-296347-fanlvxqs	534	22	incompetent	incompetent	JJ
cord-296347-fanlvxqs	535	1	(	(	-LRB-
cord-296347-fanlvxqs	535	2	Furman	Furman	NNP
cord-296347-fanlvxqs	535	3	et	et	NNP
cord-296347-fanlvxqs	535	4	a	a	DT
cord-296347-fanlvxqs	535	5	l.	l.	NN
cord-296347-fanlvxqs	535	6	,	,	,
cord-296347-fanlvxqs	535	7	2002b	2002b	CD
cord-296347-fanlvxqs	535	8	)	)	-RRB-
cord-296347-fanlvxqs	535	9	.	.	.
cord-296347-fanlvxqs	536	1	By	by	IN
cord-296347-fanlvxqs	536	2	using	use	VBG
cord-296347-fanlvxqs	536	3	an	an	DT
cord-296347-fanlvxqs	536	4	affinity	affinity	NN
cord-296347-fanlvxqs	536	5	purification	purification	NN
cord-296347-fanlvxqs	536	6	approach	approach	NN
cord-296347-fanlvxqs	536	7	similar	similar	JJ
cord-296347-fanlvxqs	536	8	to	to	IN
cord-296347-fanlvxqs	536	9	that	that	DT
cord-296347-fanlvxqs	536	10	used	use	VBN
cord-296347-fanlvxqs	536	11	for	for	IN
cord-296347-fanlvxqs	536	12	US11	US11	NNP
cord-296347-fanlvxqs	536	13	(	(	-LRB-
cord-296347-fanlvxqs	536	14	Lilley	Lilley	NNP
cord-296347-fanlvxqs	536	15	and	and	CC
cord-296347-fanlvxqs	536	16	Ploegh	Ploegh	NNP
cord-296347-fanlvxqs	536	17	,	,	,
cord-296347-fanlvxqs	536	18	2004	2004	CD
cord-296347-fanlvxqs	536	19	)	)	-RRB-
cord-296347-fanlvxqs	536	20	,	,	,
cord-296347-fanlvxqs	536	21	signal	signal	NN
cord-296347-fanlvxqs	536	22	peptide	peptide	NN
cord-296347-fanlvxqs	536	23	peptidase	peptidase	NN
cord-296347-fanlvxqs	536	24	(	(	-LRB-
cord-296347-fanlvxqs	536	25	SPP	SPP	NNP
cord-296347-fanlvxqs	536	26	)	)	-RRB-
cord-296347-fanlvxqs	536	27	was	be	VBD
cord-296347-fanlvxqs	536	28	found	find	VBN
cord-296347-fanlvxqs	536	29	as	as	IN
cord-296347-fanlvxqs	536	30	a	a	DT
cord-296347-fanlvxqs	536	31	specific	specific	JJ
cord-296347-fanlvxqs	536	32	interacting	interact	VBG
cord-296347-fanlvxqs	536	33	partner	partner	NN
cord-296347-fanlvxqs	536	34	for	for	IN
cord-296347-fanlvxqs	536	35	dislocation	dislocation	NN
cord-296347-fanlvxqs	536	36	-	-	HYPH
cord-296347-fanlvxqs	536	37	competent	competent	JJ
cord-296347-fanlvxqs	536	38	(	(	-LRB-
cord-296347-fanlvxqs	536	39	active	active	JJ
cord-296347-fanlvxqs	536	40	)	)	-RRB-
cord-296347-fanlvxqs	536	41	US2	US2	NNP
cord-296347-fanlvxqs	537	1	(	(	-LRB-
cord-296347-fanlvxqs	537	2	Loureiro	Loureiro	NNP
cord-296347-fanlvxqs	537	3	et	et	NNP
cord-296347-fanlvxqs	537	4	a	a	DT
cord-296347-fanlvxqs	537	5	l.	l.	NN
cord-296347-fanlvxqs	537	6	,	,	,
cord-296347-fanlvxqs	537	7	2006	2006	CD
cord-296347-fanlvxqs	537	8	)	)	-RRB-
cord-296347-fanlvxqs	537	9	,	,	,
cord-296347-fanlvxqs	537	10	an	an	DT
cord-296347-fanlvxqs	537	11	interaction	interaction	NN
cord-296347-fanlvxqs	537	12	that	that	WDT
cord-296347-fanlvxqs	537	13	relies	rely	VBZ
cord-296347-fanlvxqs	537	14	solely	solely	RB
cord-296347-fanlvxqs	537	15	on	on	IN
cord-296347-fanlvxqs	537	16	the	the	DT
cord-296347-fanlvxqs	537	17	presence	presence	NN
cord-296347-fanlvxqs	537	18	of	of	IN
cord-296347-fanlvxqs	537	19	the	the	DT
cord-296347-fanlvxqs	537	20	highly	highly	RB
cord-296347-fanlvxqs	537	21	hydrophobic	hydrophobic	JJ
cord-296347-fanlvxqs	537	22	US2	US2	NNP
cord-296347-fanlvxqs	537	23	tail	tail	NN
cord-296347-fanlvxqs	537	24	.	.	.
cord-296347-fanlvxqs	538	1	More	more	RBR
cord-296347-fanlvxqs	538	2	importantly	importantly	RB
cord-296347-fanlvxqs	538	3	,	,	,
cord-296347-fanlvxqs	538	4	reduction	reduction	NN
cord-296347-fanlvxqs	538	5	of	of	IN
cord-296347-fanlvxqs	538	6	SPP	spp	NN
cord-296347-fanlvxqs	538	7	levels	level	NNS
cord-296347-fanlvxqs	538	8	by	by	IN
cord-296347-fanlvxqs	538	9	RNA	RNA	NNP
cord-296347-fanlvxqs	538	10	interference	interference	NN
cord-296347-fanlvxqs	538	11	led	lead	VBD
cord-296347-fanlvxqs	538	12	to	to	IN
cord-296347-fanlvxqs	538	13	inhibition	inhibition	NN
cord-296347-fanlvxqs	538	14	of	of	IN
cord-296347-fanlvxqs	538	15	class	class	NN
cord-296347-fanlvxqs	539	1	I	-PRON-	PRP
cord-296347-fanlvxqs	539	2	MHC	MHC	NNP
cord-296347-fanlvxqs	539	3	HC	HC	NNP
cord-296347-fanlvxqs	539	4	dislocation	dislocation	NN
cord-296347-fanlvxqs	539	5	and	and	CC
cord-296347-fanlvxqs	539	6	to	to	IN
cord-296347-fanlvxqs	539	7	the	the	DT
cord-296347-fanlvxqs	539	8	discovery	discovery	NN
cord-296347-fanlvxqs	539	9	of	of	IN
cord-296347-fanlvxqs	539	10	SPP	SPP	NNP
cord-296347-fanlvxqs	539	11	as	as	IN
cord-296347-fanlvxqs	539	12	a	a	DT
cord-296347-fanlvxqs	539	13	necessary	necessary	JJ
cord-296347-fanlvxqs	539	14	factor	factor	NN
cord-296347-fanlvxqs	539	15	for	for	IN
cord-296347-fanlvxqs	539	16	the	the	DT
cord-296347-fanlvxqs	539	17	US2-mediated	us2-mediate	VBN
cord-296347-fanlvxqs	539	18	ER	ER	NNP
cord-296347-fanlvxqs	539	19	dislocation	dislocation	NN
cord-296347-fanlvxqs	539	20	pathway	pathway	NN
cord-296347-fanlvxqs	539	21	.	.	.
cord-296347-fanlvxqs	540	1	SPP	SPP	NNP
cord-296347-fanlvxqs	540	2	is	be	VBZ
cord-296347-fanlvxqs	540	3	an	an	DT
cord-296347-fanlvxqs	540	4	ER	ER	NNP
cord-296347-fanlvxqs	540	5	-resi	-resi	HYPH
cord-296347-fanlvxqs	540	6	dent	dent	NN
cord-296347-fanlvxqs	540	7	protein	protein	NN
cord-296347-fanlvxqs	540	8	o	o	NN
cord-296347-fanlvxqs	540	9	f	f	NNP
cord-296347-fanlvxqs	540	10	ap	ap	NNP
cord-296347-fanlvxqs	540	11	proximate	proximate	NN
cord-296347-fanlvxqs	540	12	ly	ly	NNP
cord-296347-fanlvxqs	540	13	45	45	CD
cord-296347-fanlvxqs	540	14	kD	kd	VB
cord-296347-fanlvxqs	540	15	a	a	DT
cord-296347-fanlvxqs	540	16	tha	tha	NN
cord-296347-fanlvxqs	540	17	t	t	NN
cord-296347-fanlvxqs	540	18	is	be	VBZ
cord-296347-fanlvxqs	540	19	predic	predic	NNP
cord-296347-fanlvxqs	540	20	ted	ted	NNP
cord-296347-fanlvxqs	540	21	to	to	TO
cord-296347-fanlvxqs	540	22	span	span	VB
cord-296347-fanlvxqs	540	23	the	the	DT
cord-296347-fanlvxqs	540	24	ER	ER	NNP
cord-296347-fanlvxqs	540	25	memb	memb	NN
cord-296347-fanlvxqs	540	26	rane	rane	NNP
cord-296347-fanlvxqs	540	27	seven	seven	CD
cord-296347-fanlvxqs	540	28	to	to	IN
cord-296347-fanlvxqs	540	29	nine	nine	CD
cord-296347-fanlvxqs	540	30	times	time	NNS
cord-296347-fanlvxqs	541	1	(	(	-LRB-
cord-296347-fanlvxqs	541	2	Friedmann	Friedmann	NNP
cord-296347-fanlvxqs	541	3	et	et	NNP
cord-296347-fanlvxqs	541	4	al	al	NNP
cord-296347-fanlvxqs	541	5	.	.	NNP
cord-296347-fanlvxqs	541	6	,	,	,
cord-296347-fanlvxqs	541	7	2004	2004	CD
cord-296347-fanlvxqs	541	8	)	)	-RRB-
cord-296347-fanlvxqs	541	9	,	,	,
cord-296347-fanlvxqs	541	10	an	an	DT
cord-296347-fanlvxqs	541	11	d	d	NN
cord-296347-fanlvxqs	541	12	a	a	DT
cord-296347-fanlvxqs	541	13	memb	memb	NN
cord-296347-fanlvxqs	541	14	er	er	UH
cord-296347-fanlvxqs	541	15	of	of	IN
cord-296347-fanlvxqs	541	16	the	the	DT
cord-296347-fanlvxqs	541	17	presenili	presenili	NNP
cord-296347-fanlvxqs	541	18	n	n	NNP
cord-296347-fanlvxqs	541	19	(	(	-LRB-
cord-296347-fanlvxqs	541	20	PS)/SP	PS)/SP	NNP
cord-296347-fanlvxqs	541	21	P	P	NNP
cord-296347-fanlvxqs	541	22	-	-	HYPH
cord-296347-fanlvxqs	541	23	Like	like	JJ
cord-296347-fanlvxqs	541	24	(	(	-LRB-
cord-296347-fanlvxqs	541	25	SPPL	SPPL	NNP
cord-296347-fanlvxqs	541	26	)	)	-RRB-
cord-296347-fanlvxqs	541	27	superfam	superfam	NNP
cord-296347-fanlvxqs	541	28	ily	ily	NNP
cord-296347-fanlvxqs	541	29	of	of	IN
cord-296347-fanlvxqs	541	30	intrame	intrame	NNP
cord-296347-fanlvxqs	541	31	mbran	mbran	NNP
cord-296347-fanlvxqs	541	32	e	e	NNP
cord-296347-fanlvxqs	541	33	-	-	JJ
cord-296347-fanlvxqs	541	34	cleaving	cleaving	JJ
cord-296347-fanlvxqs	541	35	aspartic	aspartic	JJ
cord-296347-fanlvxqs	541	36	protea	protea	NN
cord-296347-fanlvxqs	541	37	ses	ses	NN
cord-296347-fanlvxqs	541	38	(	(	-LRB-
cord-296347-fanlvxqs	541	39	Weihof	Weihof	NNP
cord-296347-fanlvxqs	541	40	en	en	NNP
cord-296347-fanlvxqs	541	41	et	et	FW
cord-296347-fanlvxqs	541	42	al	al	NNP
cord-296347-fanlvxqs	541	43	.	.	NNP
cord-296347-fanlvxqs	541	44	,	,	,
cord-296347-fanlvxqs	541	45	2002	2002	CD
cord-296347-fanlvxqs	541	46	)	)	-RRB-
cord-296347-fanlvxqs	541	47	.	.	.
cord-296347-fanlvxqs	542	1	These	these	DT
cord-296347-fanlvxqs	542	2	protea	protea	NN
cord-296347-fanlvxqs	542	3	ses	se	NNS
cord-296347-fanlvxqs	542	4	are	be	VBP
cord-296347-fanlvxqs	542	5	charac	charac	NNS
cord-296347-fanlvxqs	542	6	terized	terize	VBN
cord-296347-fanlvxqs	542	7	by	by	IN
cord-296347-fanlvxqs	542	8	the	the	DT
cord-296347-fanlvxqs	542	9	ability	ability	NN
cord-296347-fanlvxqs	542	10	to	to	TO
cord-296347-fanlvxqs	542	11	cleave	cleave	VB
cord-296347-fanlvxqs	542	12	substr	substr	NN
cord-296347-fanlvxqs	542	13	ate	eat	VBD
cord-296347-fanlvxqs	542	14	pol	pol	NN
cord-296347-fanlvxqs	542	15	ypeptides	ypeptide	NNS
cord-296347-fanlvxqs	542	16	with	with	IN
cord-296347-fanlvxqs	542	17	in	in	IN
cord-296347-fanlvxqs	542	18	a	a	DT
cord-296347-fanlvxqs	542	19	transm	transm	NNP
cord-296347-fanlvxqs	542	20	embran	embran	NNP
cord-296347-fanlvxqs	542	21	e	e	NNP
cord-296347-fanlvxqs	542	22	region	region	NN
cord-296347-fanlvxqs	542	23	and	and	CC
cord-296347-fanlvxqs	542	24	by	by	IN
cord-296347-fanlvxqs	542	25	pos	pos	NNP
cord-296347-fanlvxqs	542	26	sessing	sesse	VBG
cord-296347-fanlvxqs	542	27	two	two	CD
cord-296347-fanlvxqs	542	28	active	active	JJ
cord-296347-fanlvxqs	542	29	site	site	NN
cord-296347-fanlvxqs	542	30	aspartat	aspartat	NNP
cord-296347-fanlvxqs	542	31	e	e	NNP
cord-296347-fanlvxqs	542	32	(	(	-LRB-
cord-296347-fanlvxqs	542	33	D	D	NNP
cord-296347-fanlvxqs	542	34	)	)	-RRB-
cord-296347-fanlvxqs	542	35	resid	resid	NNP
cord-296347-fanlvxqs	542	36	ues	ues	NNP
cord-296347-fanlvxqs	542	37	(	(	-LRB-
cord-296347-fanlvxqs	542	38	ita	ita	NNP
cord-296347-fanlvxqs	542	39	licized	licized	NNP
cord-296347-fanlvxqs	542	40	)	)	-RRB-
cord-296347-fanlvxqs	542	41	within	within	IN
cord-296347-fanlvxqs	542	42	the	the	DT
cord-296347-fanlvxqs	542	43	con	con	NN
cord-296347-fanlvxqs	542	44	served	serve	VBD
cord-296347-fanlvxqs	542	45	motifs	motif	NNS
cord-296347-fanlvxqs	542	46	Y	Y	NNP
cord-296347-fanlvxqs	542	47	D	D	NNP
cord-296347-fanlvxqs	542	48	and	and	CC
cord-296347-fanlvxqs	542	49	LGLG	LGLG	NNP
cord-296347-fanlvxqs	542	50	D	D	NNP
cord-296347-fanlvxqs	542	51	in	in	IN
cord-296347-fanlvxqs	542	52	adjacent	adjacent	JJ
cord-296347-fanlvxqs	542	53	memb	memb	NNP
cord-296347-fanlvxqs	542	54	ranespan	ranespan	NNP
cord-296347-fanlvxqs	542	55	ning	ning	NNP
cord-296347-fanlvxqs	542	56	regio	regio	NNP
cord-296347-fanlvxqs	542	57	ns	ns	XX
cord-296347-fanlvxqs	543	1	(	(	-LRB-
cord-296347-fanlvxqs	543	2	Martoglio	Martoglio	NNP
cord-296347-fanlvxqs	544	1	an	an	DT
cord-296347-fanlvxqs	544	2	d	d	NNP
cord-296347-fanlvxqs	544	3	Golde	Golde	NNP
cord-296347-fanlvxqs	544	4	,	,	,
cord-296347-fanlvxqs	544	5	2003	2003	CD
cord-296347-fanlvxqs	544	6	;	;	:
cord-296347-fanlvxqs	545	1	Wan	Wan	NNP
cord-296347-fanlvxqs	545	2	g	g	NNP
cord-296347-fanlvxqs	545	3	et	et	FW
cord-296347-fanlvxqs	545	4	al	al	NNP
cord-296347-fanlvxqs	545	5	.	.	.
cord-296347-fanlvxqs	546	1	,	,	,
cord-296347-fanlvxqs	546	2	2006a	2006a	CD
cord-296347-fanlvxqs	546	3	;	;	:
cord-296347-fanlvxqs	546	4	Weihof	Weihof	NNP
cord-296347-fanlvxqs	547	1	en	en	NNP
cord-296347-fanlvxqs	547	2	et	et	FW
cord-296347-fanlvxqs	547	3	al	al	NNP
cord-296347-fanlvxqs	547	4	.	.	NNP
cord-296347-fanlvxqs	547	5	,	,	,
cord-296347-fanlvxqs	547	6	2002	2002	CD
cord-296347-fanlvxqs	547	7	)	)	-RRB-
cord-296347-fanlvxqs	547	8	.	.	.
cord-296347-fanlvxqs	548	1	There	there	EX
cord-296347-fanlvxqs	548	2	are	be	VBP
cord-296347-fanlvxqs	548	3	seven	seven	CD
cord-296347-fanlvxqs	548	4	related	related	JJ
cord-296347-fanlvxqs	548	5	members	member	NNS
cord-296347-fanlvxqs	548	6	of	of	IN
cord-296347-fanlvxqs	548	7	the	the	DT
cord-296347-fanlvxqs	548	8	PS	PS	NNP
cord-296347-fanlvxqs	548	9	/	/	SYM
cord-296347-fanlvxqs	548	10	SPP	SPP	NNP
cord-296347-fanlvxqs	548	11	L	L	NNP
cord-296347-fanlvxqs	548	12	superfam	superfam	NNP
cord-296347-fanlvxqs	548	13	ily	ily	NNP
cord-296347-fanlvxqs	548	14	in	in	IN
cord-296347-fanlvxqs	548	15	the	the	DT
cord-296347-fanlvxqs	548	16	human	human	JJ
cord-296347-fanlvxqs	548	17	genome	genome	NN
cord-296347-fanlvxqs	548	18	:	:	:
cord-296347-fanlvxqs	548	19	PS	PS	NNP
cord-296347-fanlvxqs	548	20	-1	-1	NNP
cord-296347-fanlvxqs	548	21	,	,	,
cord-296347-fanlvxqs	548	22	PS	PS	NNP
cord-296347-fanlvxqs	548	23	-2	-2	NNP
cord-296347-fanlvxqs	548	24	,	,	,
cord-296347-fanlvxqs	548	25	SPP	SPP	NNP
cord-296347-fanlvxqs	548	26	an	an	DT
cord-296347-fanlvxqs	548	27	d	d	NN
cord-296347-fanlvxqs	548	28	four	four	CD
cord-296347-fanlvxqs	548	29	SPP	SPP	NNP
cord-296347-fanlvxqs	548	30	-Like	-like	IN
cord-296347-fanlvxqs	548	31	pro	pro	JJ
cord-296347-fanlvxqs	548	32	teins	tein	NNS
cord-296347-fanlvxqs	548	33	,	,	.
cord-296347-fanlvxqs	549	1	SPP2	spp2	VB
cord-296347-fanlvxqs	549	2	a	a	DT
cord-296347-fanlvxqs	549	3	,	,	,
cord-296347-fanlvxqs	549	4	SPP	SPP	NNP
cord-296347-fanlvxqs	549	5	2b	2b	CD
cord-296347-fanlvxqs	549	6	,	,	,
cord-296347-fanlvxqs	549	7	and	and	CC
cord-296347-fanlvxqs	549	8	SPP2c	SPP2c	NNP
cord-296347-fanlvxqs	549	9	,	,	,
cord-296347-fanlvxqs	549	10	an	an	DT
cord-296347-fanlvxqs	549	11	d	d	NN
cord-296347-fanlvxqs	549	12	SPP	SPP	NNP
cord-296347-fanlvxqs	549	13	3	3	CD
cord-296347-fanlvxqs	550	1	(	(	-LRB-
cord-296347-fanlvxqs	550	2	M	M	NNP
cord-296347-fanlvxqs	550	3	artoglio	artoglio	NNP
cord-296347-fanlvxqs	550	4	and	and	CC
cord-296347-fanlvxqs	550	5	Gold	Gold	NNP
cord-296347-fanlvxqs	550	6	e	e	NNP
cord-296347-fanlvxqs	550	7	,	,	,
cord-296347-fanlvxqs	550	8	2003	2003	CD
cord-296347-fanlvxqs	550	9	)	)	-RRB-
cord-296347-fanlvxqs	550	10	.	.	.
cord-296347-fanlvxqs	551	1	Presen	Presen	NNP
cord-296347-fanlvxqs	551	2	ilins	ilin	VBZ
cord-296347-fanlvxqs	551	3	1	1	CD
cord-296347-fanlvxqs	551	4	and	and	CC
cord-296347-fanlvxqs	551	5	2	2	CD
cord-296347-fanlvxqs	551	6	are	be	VBP
cord-296347-fanlvxqs	551	7	the	the	DT
cord-296347-fanlvxqs	551	8	catalytic	catalytic	JJ
cord-296347-fanlvxqs	551	9	compone	compone	NNP
cord-296347-fanlvxqs	551	10	nts	nts	NNPS
cord-296347-fanlvxqs	551	11	of	of	IN
cord-296347-fanlvxqs	551	12	gsec	gsec	NNP
cord-296347-fanlvxqs	551	13	retase	retase	NNP
cord-296347-fanlvxqs	551	14	,	,	,
cord-296347-fanlvxqs	551	15	a	a	DT
cord-296347-fanlvxqs	551	16	tetr	tetr	NNP
cord-296347-fanlvxqs	551	17	americ	americ	NNP
cord-296347-fanlvxqs	551	18	comp	comp	NNP
cord-296347-fanlvxqs	551	19	lex	lex	NNP
cord-296347-fanlvxqs	551	20	containin	containin	NNP
cord-296347-fanlvxqs	551	21	g	g	NNP
cord-296347-fanlvxqs	551	22	PS	PS	NNP
cord-296347-fanlvxqs	551	23	and	and	CC
cord-296347-fanlvxqs	551	24	three	three	CD
cord-296347-fanlvxqs	551	25	other	other	JJ
cord-296347-fanlvxqs	551	26	subunits	subunit	NNS
cord-296347-fanlvxqs	551	27	.	.	.
cord-296347-fanlvxqs	552	1	PSs	PSs	NNP
cord-296347-fanlvxqs	552	2	play	play	VBP
cord-296347-fanlvxqs	552	3	a	a	DT
cord-296347-fanlvxqs	552	4	role	role	NN
cord-296347-fanlvxqs	552	5	in	in	IN
cord-296347-fanlvxqs	552	6	processing	processing	NN
cord-296347-fanlvxqs	552	7	of	of	IN
cord-296347-fanlvxqs	552	8	the	the	DT
cord-296347-fanlvxqs	552	9	b	b	NN
cord-296347-fanlvxqs	552	10	-	-	HYPH
cord-296347-fanlvxqs	552	11	amyloid	amyloid	NN
cord-296347-fanlvxqs	552	12	precursor	precursor	NN
cord-296347-fanlvxqs	552	13	protein	protein	NN
cord-296347-fanlvxqs	552	14	(	(	-LRB-
cord-296347-fanlvxqs	552	15	APP	app	NN
cord-296347-fanlvxqs	552	16	)	)	-RRB-
cord-296347-fanlvxqs	552	17	into	into	IN
cord-296347-fanlvxqs	552	18	Ab40	Ab40	NNPS
cord-296347-fanlvxqs	552	19	and	and	CC
cord-296347-fanlvxqs	553	1	Ab42	Ab42	NNP
cord-296347-fanlvxqs	553	2	,	,	,
cord-296347-fanlvxqs	553	3	peptides	peptide	NNS
cord-296347-fanlvxqs	553	4	that	that	WDT
cord-296347-fanlvxqs	553	5	constitute	constitute	VBP
cord-296347-fanlvxqs	553	6	the	the	DT
cord-296347-fanlvxqs	553	7	principal	principal	JJ
cord-296347-fanlvxqs	553	8	components	component	NNS
cord-296347-fanlvxqs	553	9	of	of	IN
cord-296347-fanlvxqs	553	10	the	the	DT
cord-296347-fanlvxqs	553	11	b	b	NN
cord-296347-fanlvxqs	553	12	-	-	HYPH
cord-296347-fanlvxqs	553	13	amyloid	amyloid	NN
cord-296347-fanlvxqs	553	14	plaques	plaque	NNS
cord-296347-fanlvxqs	553	15	in	in	IN
cord-296347-fanlvxqs	553	16	Alzheimer	Alzheimer	NNP
cord-296347-fanlvxqs	553	17	's	's	POS
cord-296347-fanlvxqs	553	18	disease	disease	NN
cord-296347-fanlvxqs	553	19	(	(	-LRB-
cord-296347-fanlvxqs	553	20	AD	ad	NN
cord-296347-fanlvxqs	553	21	)	)	-RRB-
cord-296347-fanlvxqs	554	1	;	;	:
cord-296347-fanlvxqs	554	2	PSs	PSs	NNP
cord-296347-fanlvxqs	554	3	are	be	VBP
cord-296347-fanlvxqs	554	4	also	also	RB
cord-296347-fanlvxqs	554	5	required	require	VBN
cord-296347-fanlvxqs	554	6	for	for	IN
cord-296347-fanlvxqs	554	7	development	development	NN
cord-296347-fanlvxqs	554	8	due	due	IN
cord-296347-fanlvxqs	554	9	to	to	IN
cord-296347-fanlvxqs	554	10	processing	processing	NN
cord-296347-fanlvxqs	554	11	of	of	IN
cord-296347-fanlvxqs	554	12	the	the	DT
cord-296347-fanlvxqs	554	13	Notch	Notch	NNP
cord-296347-fanlvxqs	554	14	receptor	receptor	NN
cord-296347-fanlvxqs	554	15	by	by	IN
cord-296347-fanlvxqs	554	16	g	g	NNP
cord-296347-fanlvxqs	554	17	-	-	HYPH
cord-296347-fanlvxqs	554	18	secretase	secretase	NNP
cord-296347-fanlvxqs	554	19	(	(	-LRB-
cord-296347-fanlvxqs	554	20	Selkoe	Selkoe	NNP
cord-296347-fanlvxqs	554	21	and	and	CC
cord-296347-fanlvxqs	554	22	Kopan	Kopan	NNP
cord-296347-fanlvxqs	554	23	,	,	,
cord-296347-fanlvxqs	554	24	2003	2003	CD
cord-296347-fanlvxqs	554	25	)	)	-RRB-
cord-296347-fanlvxqs	554	26	and	and	CC
cord-296347-fanlvxqs	554	27	might	may	MD
cord-296347-fanlvxqs	554	28	be	be	VB
cord-296347-fanlvxqs	554	29	involved	involve	VBN
cord-296347-fanlvxqs	554	30	in	in	IN
cord-296347-fanlvxqs	554	31	intracellular	intracellular	JJ
cord-296347-fanlvxqs	554	32	traffi	traffi	NNP
cord-296347-fanlvxqs	554	33	cking	cking	JJ
cord-296347-fanlvxqs	554	34	(	(	-LRB-
cord-296347-fanlvxqs	554	35	Si	Si	NNP
cord-296347-fanlvxqs	554	36	sodia	sodia	NNP
cord-296347-fanlvxqs	554	37	and	and	CC
cord-296347-fanlvxqs	554	38	St	St	NNP
cord-296347-fanlvxqs	554	39	George	George	NNP
cord-296347-fanlvxqs	554	40	-Hyslop	-Hyslop	NNP
cord-296347-fanlvxqs	554	41	,	,	,
cord-296347-fanlvxqs	554	42	2002	2002	CD
cord-296347-fanlvxqs	554	43	;	;	:
cord-296347-fanlvxqs	554	44	Wang	Wang	NNP
cord-296347-fanlvxqs	554	45	et	et	NNP
cord-296347-fanlvxqs	554	46	al	al	NNP
cord-296347-fanlvxqs	554	47	.	.	NNP
cord-296347-fanlvxqs	554	48	,	,	,
cord-296347-fanlvxqs	554	49	2006	2006	CD
cord-296347-fanlvxqs	554	50	c	c	NN
cord-296347-fanlvxqs	554	51	)	)	-RRB-
cord-296347-fanlvxqs	554	52	.	.	.
cord-296347-fanlvxqs	555	1	The	the	DT
cord-296347-fanlvxqs	555	2	function	function	NN
cord-296347-fanlvxqs	555	3	of	of	IN
cord-296347-fanlvxqs	555	4	the	the	DT
cord-296347-fanlvxqs	555	5	four	four	CD
cord-296347-fanlvxqs	555	6	SPP	SPP	NNS
cord-296347-fanlvxqs	555	7	-	-	HYPH
cord-296347-fanlvxqs	555	8	like	like	JJ
cord-296347-fanlvxqs	555	9	proteins	protein	NNS
cord-296347-fanlvxqs	555	10	is	be	VBZ
cord-296347-fanlvxqs	555	11	,	,	,
cord-296347-fanlvxqs	555	12	at	at	IN
cord-296347-fanlvxqs	555	13	this	this	DT
cord-296347-fanlvxqs	555	14	point	point	NN
cord-296347-fanlvxqs	555	15	,	,	,
cord-296347-fanlvxqs	555	16	unknown	unknown	JJ
cord-296347-fanlvxqs	555	17	,	,	,
cord-296347-fanlvxqs	555	18	but	but	CC
cord-296347-fanlvxqs	555	19	the	the	DT
cord-296347-fanlvxqs	555	20	role	role	NN
cord-296347-fanlvxqs	555	21	of	of	IN
cord-296347-fanlvxqs	555	22	intramembrane	intramembrane	NN
cord-296347-fanlvxqs	555	23	-	-	HYPH
cord-296347-fanlvxqs	555	24	cleaving	cleave	VBG
cord-296347-fanlvxqs	555	25	proteases	protease	NNS
cord-296347-fanlvxqs	555	26	is	be	VBZ
cord-296347-fanlvxqs	555	27	usually	usually	RB
cord-296347-fanlvxqs	555	28	to	to	TO
cord-296347-fanlvxqs	555	29	liberate	liberate	VB
cord-296347-fanlvxqs	555	30	signaling	signal	VBG
cord-296347-fanlvxqs	555	31	molecules	molecule	NNS
cord-296347-fanlvxqs	555	32	from	from	IN
cord-296347-fanlvxqs	555	33	membrane	membrane	NN
cord-296347-fanlvxqs	555	34	-	-	HYPH
cord-296347-fanlvxqs	555	35	bound	bind	VBN
cord-296347-fanlvxqs	555	36	precursors	precursor	NNS
cord-296347-fanlvxqs	555	37	with	with	IN
cord-296347-fanlvxqs	555	38	consequent	consequent	JJ
cord-296347-fanlvxqs	555	39	activation	activation	NN
cord-296347-fanlvxqs	555	40	or	or	CC
cord-296347-fanlvxqs	555	41	repression	repression	NN
cord-296347-fanlvxqs	555	42	of	of	IN
cord-296347-fanlvxqs	555	43	signaling	signal	VBG
cord-296347-fanlvxqs	555	44	cascades	cascade	NNS
cord-296347-fanlvxqs	556	1	(	(	-LRB-
cord-296347-fanlvxqs	556	2	Fortini	Fortini	NNP
cord-296347-fanlvxqs	556	3	,	,	,
cord-296347-fanlvxqs	556	4	2002	2002	CD
cord-296347-fanlvxqs	556	5	;	;	:
cord-296347-fanlvxqs	556	6	Kopan	Kopan	NNP
cord-296347-fanlvxqs	556	7	and	and	CC
cord-296347-fanlvxqs	556	8	Ilagan	Ilagan	NNP
cord-296347-fanlvxqs	556	9	,	,	,
cord-296347-fanlvxqs	556	10	2004	2004	CD
cord-296347-fanlvxqs	556	11	;	;	:
cord-296347-fanlvxqs	556	12	Martoglio	Martoglio	NNP
cord-296347-fanlvxqs	556	13	and	and	CC
cord-296347-fanlvxqs	556	14	Golde	Golde	NNP
cord-296347-fanlvxqs	556	15	,	,	,
cord-296347-fanlvxqs	556	16	2003	2003	CD
cord-296347-fanlvxqs	556	17	;	;	:
cord-296347-fanlvxqs	557	1	Parent	parent	NN
cord-296347-fanlvxqs	557	2	et	et	NNP
cord-296347-fanlvxqs	557	3	al	al	NNP
cord-296347-fanlvxqs	557	4	.	.	.
cord-296347-fanlvxqs	558	1	,	,	,
cord-296347-fanlvxqs	558	2	2005	2005	CD
cord-296347-fanlvxqs	558	3	;	;	:
cord-296347-fanlvxqs	558	4	Xia	Xia	NNP
cord-296347-fanlvxqs	558	5	and	and	CC
cord-296347-fanlvxqs	558	6	Wolfe	Wolfe	NNP
cord-296347-fanlvxqs	558	7	,	,	,
cord-296347-fanlvxqs	558	8	2003	2003	CD
cord-296347-fanlvxqs	558	9	)	)	-RRB-
cord-296347-fanlvxqs	558	10	.	.	.
cord-296347-fanlvxqs	559	1	In	in	IN
cord-296347-fanlvxqs	559	2	humans	human	NNS
cord-296347-fanlvxqs	559	3	,	,	,
cord-296347-fanlvxqs	559	4	SPP	SPP	NNP
cord-296347-fanlvxqs	559	5	performs	perform	VBZ
cord-296347-fanlvxqs	559	6	an	an	DT
cord-296347-fanlvxqs	559	7	important	important	JJ
cord-296347-fanlvxqs	559	8	immunological	immunological	JJ
cord-296347-fanlvxqs	559	9	function	function	NN
cord-296347-fanlvxqs	559	10	as	as	IN
cord-296347-fanlvxqs	559	11	it	-PRON-	PRP
cord-296347-fanlvxqs	559	12	generates	generate	VBZ
cord-296347-fanlvxqs	559	13	the	the	DT
cord-296347-fanlvxqs	559	14	peptide	peptide	NN
cord-296347-fanlvxqs	559	15	ligands	ligand	NNS
cord-296347-fanlvxqs	559	16	for	for	IN
cord-296347-fanlvxqs	559	17	the	the	DT
cord-296347-fanlvxqs	559	18	nonclassical	nonclassical	JJ
cord-296347-fanlvxqs	559	19	class	class	NN
cord-296347-fanlvxqs	560	1	I	-PRON-	PRP
cord-296347-fanlvxqs	560	2	MHC	MHC	NNP
cord-296347-fanlvxqs	560	3	molecule	molecule	NN
cord-296347-fanlvxqs	560	4	HLA	HLA	NNP
cord-296347-fanlvxqs	560	5	-	-	HYPH
cord-296347-fanlvxqs	560	6	E.	E.	NNP
cord-296347-fanlvxqs	561	1	On	on	IN
cord-296347-fanlvxqs	561	2	insertion	insertion	NN
cord-296347-fanlvxqs	561	3	of	of	IN
cord-296347-fanlvxqs	561	4	secretory	secretory	NN
cord-296347-fanlvxqs	561	5	or	or	CC
cord-296347-fanlvxqs	561	6	type	type	NN
cord-296347-fanlvxqs	561	7	II	ii	CD
cord-296347-fanlvxqs	561	8	membrane	membrane	NN
cord-296347-fanlvxqs	561	9	proteins	protein	NNS
cord-296347-fanlvxqs	561	10	into	into	IN
cord-296347-fanlvxqs	561	11	the	the	DT
cord-296347-fanlvxqs	561	12	ER	ER	NNP
cord-296347-fanlvxqs	561	13	,	,	,
cord-296347-fanlvxqs	561	14	their	-PRON-	PRP$
cord-296347-fanlvxqs	561	15	signal	signal	NN
cord-296347-fanlvxqs	561	16	sequence	sequence	NN
cord-296347-fanlvxqs	561	17	is	be	VBZ
cord-296347-fanlvxqs	561	18	cleaved	cleave	VBN
cord-296347-fanlvxqs	561	19	by	by	IN
cord-296347-fanlvxqs	561	20	the	the	DT
cord-296347-fanlvxqs	561	21	ER	ER	NNP
cord-296347-fanlvxqs	561	22	luminal	luminal	JJ
cord-296347-fanlvxqs	561	23	protein	protein	NN
cord-296347-fanlvxqs	561	24	signal	signal	NN
cord-296347-fanlvxqs	561	25	peptidase	peptidase	NN
cord-296347-fanlvxqs	561	26	,	,	,
cord-296347-fanlvxqs	561	27	leaving	leave	VBG
cord-296347-fanlvxqs	561	28	the	the	DT
cord-296347-fanlvxqs	561	29	signal	signal	NN
cord-296347-fanlvxqs	561	30	peptide	peptide	NN
cord-296347-fanlvxqs	561	31	anchored	anchor	VBN
cord-296347-fanlvxqs	561	32	in	in	IN
cord-296347-fanlvxqs	561	33	the	the	DT
cord-296347-fanlvxqs	561	34	ER	ER	NNP
cord-296347-fanlvxqs	561	35	membrane	membrane	NN
cord-296347-fanlvxqs	561	36	.	.	.
cord-296347-fanlvxqs	562	1	The	the	DT
cord-296347-fanlvxqs	562	2	ER	ER	NNP
cord-296347-fanlvxqs	562	3	membrane	membrane	NN
cord-296347-fanlvxqs	562	4	-	-	HYPH
cord-296347-fanlvxqs	562	5	anchored	anchor	VBN
cord-296347-fanlvxqs	562	6	signal	signal	NN
cord-296347-fanlvxqs	562	7	peptide	peptide	NN
cord-296347-fanlvxqs	562	8	is	be	VBZ
cord-296347-fanlvxqs	562	9	subsequently	subsequently	RB
cord-296347-fanlvxqs	562	10	cleaved	cleave	VBN
cord-296347-fanlvxqs	562	11	by	by	IN
cord-296347-fanlvxqs	562	12	the	the	DT
cord-296347-fanlvxqs	562	13	intramembrane	intramembrane	NN
cord-296347-fanlvxqs	562	14	-	-	HYPH
cord-296347-fanlvxqs	562	15	cleaving	cleave	VBG
cord-296347-fanlvxqs	562	16	SPP	SPP	NNS
cord-296347-fanlvxqs	562	17	within	within	IN
cord-296347-fanlvxqs	562	18	the	the	DT
cord-296347-fanlvxqs	562	19	transmembrane	transmembrane	NNP
cord-296347-fanlvxqs	562	20	region	region	NN
cord-296347-fanlvxqs	562	21	.	.	.
cord-296347-fanlvxqs	563	1	The	the	DT
cord-296347-fanlvxqs	563	2	resulting	result	VBG
cord-296347-fanlvxqs	563	3	signal	signal	NN
cord-296347-fanlvxqs	563	4	peptide	peptide	NN
cord-296347-fanlvxqs	563	5	fragments	fragment	NNS
cord-296347-fanlvxqs	563	6	are	be	VBP
cord-296347-fanlvxqs	563	7	released	release	VBN
cord-296347-fanlvxqs	563	8	into	into	IN
cord-296347-fanlvxqs	563	9	the	the	DT
cord-296347-fanlvxqs	563	10	cytosol	cytosol	NN
cord-296347-fanlvxqs	563	11	(	(	-LRB-
cord-296347-fanlvxqs	563	12	N	n	CD
cord-296347-fanlvxqs	563	13	-	-	HYPH
cord-296347-fanlvxqs	563	14	terminal	terminal	JJ
cord-296347-fanlvxqs	563	15	portion	portion	NN
cord-296347-fanlvxqs	563	16	)	)	-RRB-
cord-296347-fanlvxqs	563	17	or	or	CC
cord-296347-fanlvxqs	563	18	into	into	IN
cord-296347-fanlvxqs	563	19	the	the	DT
cord-296347-fanlvxqs	563	20	ER	ER	NNP
cord-296347-fanlvxqs	563	21	lumen	lumen	NN
cord-296347-fanlvxqs	563	22	(	(	-LRB-
cord-296347-fanlvxqs	563	23	C	c	NN
cord-296347-fanlvxqs	563	24	-	-	HYPH
cord-296347-fanlvxqs	563	25	terminal	terminal	NN
cord-296347-fanlvxqs	563	26	portion	portion	NN
cord-296347-fanlvxqs	563	27	)	)	-RRB-
cord-296347-fanlvxqs	563	28	.	.	.
cord-296347-fanlvxqs	564	1	The	the	DT
cord-296347-fanlvxqs	564	2	latter	latter	JJ
cord-296347-fanlvxqs	564	3	peptides	peptide	NNS
cord-296347-fanlvxqs	564	4	may	may	MD
cord-296347-fanlvxqs	564	5	easily	easily	RB
cord-296347-fanlvxqs	564	6	bind	bind	VB
cord-296347-fanlvxqs	564	7	to	to	IN
cord-296347-fanlvxqs	564	8	class	class	NN
cord-296347-fanlvxqs	564	9	I	-PRON-	PRP
cord-296347-fanlvxqs	564	10	MHC	MHC	NNP
cord-296347-fanlvxqs	564	11	molecules	molecule	NNS
cord-296347-fanlvxqs	564	12	in	in	IN
cord-296347-fanlvxqs	564	13	the	the	DT
cord-296347-fanlvxqs	564	14	ER	ER	NNP
cord-296347-fanlvxqs	564	15	lumen	lumen	NN
cord-296347-fanlvxqs	564	16	.	.	.
cord-296347-fanlvxqs	565	1	The	the	DT
cord-296347-fanlvxqs	565	2	HLA	HLA	NNP
cord-296347-fanlvxqs	565	3	-	-	HYPH
cord-296347-fanlvxqs	565	4	A2	A2	NNP
cord-296347-fanlvxqs	565	5	molecule	molecule	NN
cord-296347-fanlvxqs	565	6	,	,	,
cord-296347-fanlvxqs	565	7	for	for	IN
cord-296347-fanlvxqs	565	8	instance	instance	NN
cord-296347-fanlvxqs	565	9	,	,	,
cord-296347-fanlvxqs	565	10	is	be	VBZ
cord-296347-fanlvxqs	565	11	known	know	VBN
cord-296347-fanlvxqs	565	12	to	to	TO
cord-296347-fanlvxqs	565	13	bind	bind	VB
cord-296347-fanlvxqs	565	14	signal	signal	NN
cord-296347-fanlvxqs	565	15	sequence	sequence	NN
cord-296347-fanlvxqs	565	16	-	-	HYPH
cord-296347-fanlvxqs	565	17	derived	derive	VBN
cord-296347-fanlvxqs	565	18	peptides	peptide	NNS
cord-296347-fanlvxqs	565	19	.	.	.
cord-296347-fanlvxqs	566	1	The	the	DT
cord-296347-fanlvxqs	566	2	N	n	CD
cord-296347-fanlvxqs	566	3	-	-	HYPH
cord-296347-fanlvxqs	566	4	terminal	terminal	JJ
cord-296347-fanlvxqs	566	5	signal	signal	NN
cord-296347-fanlvxqs	566	6	sequence	sequence	NN
cord-296347-fanlvxqs	566	7	fragments	fragment	NNS
cord-296347-fanlvxqs	566	8	are	be	VBP
cord-296347-fanlvxqs	566	9	TAP	tap	NN
cord-296347-fanlvxqs	566	10	-	-	HYPH
cord-296347-fanlvxqs	566	11	transported	transport	VBN
cord-296347-fanlvxqs	566	12	into	into	IN
cord-296347-fanlvxqs	566	13	the	the	DT
cord-296347-fanlvxqs	566	14	ER	ER	NNP
cord-296347-fanlvxqs	566	15	lumen	lumen	NN
cord-296347-fanlvxqs	566	16	and	and	CC
cord-296347-fanlvxqs	566	17	bind	bind	VB
cord-296347-fanlvxqs	566	18	to	to	IN
cord-296347-fanlvxqs	566	19	HLA	HLA	NNP
cord-296347-fanlvxqs	566	20	-	-	HYPH
cord-296347-fanlvxqs	566	21	E	E	NNP
cord-296347-fanlvxqs	566	22	(	(	-LRB-
cord-296347-fanlvxqs	566	23	Lemberg	Lemberg	NNP
cord-296347-fanlvxqs	566	24	et	et	FW
cord-296347-fanlvxqs	566	25	al	al	NNP
cord-296347-fanlvxqs	566	26	.	.	NNP
cord-296347-fanlvxqs	566	27	,	,	,
cord-296347-fanlvxqs	566	28	2001	2001	CD
cord-296347-fanlvxqs	566	29	)	)	-RRB-
cord-296347-fanlvxqs	566	30	.	.	.
cord-296347-fanlvxqs	567	1	By	by	IN
cord-296347-fanlvxqs	567	2	presenting	present	VBG
cord-296347-fanlvxqs	567	3	fragments	fragment	NNS
cord-296347-fanlvxqs	567	4	derived	derive	VBN
cord-296347-fanlvxqs	567	5	from	from	IN
cord-296347-fanlvxqs	567	6	the	the	DT
cord-296347-fanlvxqs	567	7	signal	signal	NN
cord-296347-fanlvxqs	567	8	sequences	sequence	NNS
cord-296347-fanlvxqs	567	9	of	of	IN
cord-296347-fanlvxqs	567	10	classical	classical	JJ
cord-296347-fanlvxqs	567	11	class	class	NN
cord-296347-fanlvxqs	567	12	I	-PRON-	PRP
cord-296347-fanlvxqs	567	13	MHC	MHC	NNP
cord-296347-fanlvxqs	567	14	molecules	molecule	NNS
cord-296347-fanlvxqs	567	15	,	,	,
cord-296347-fanlvxqs	567	16	HLA	HLA	NNP
cord-296347-fanlvxqs	567	17	-	-	HYPH
cord-296347-fanlvxqs	567	18	E	E	NNP
cord-296347-fanlvxqs	567	19	monitors	monitor	VBZ
cord-296347-fanlvxqs	567	20	the	the	DT
cord-296347-fanlvxqs	567	21	presence	presence	NN
cord-296347-fanlvxqs	567	22	of	of	IN
cord-296347-fanlvxqs	567	23	classical	classical	JJ
cord-296347-fanlvxqs	567	24	class	class	NN
cord-296347-fanlvxqs	567	25	I	-PRON-	PRP
cord-296347-fanlvxqs	567	26	MHC	MHC	NNP
cord-296347-fanlvxqs	567	27	molecules	molecule	NNS
cord-296347-fanlvxqs	567	28	.	.	.
cord-296347-fanlvxqs	568	1	This	this	DT
cord-296347-fanlvxqs	568	2	is	be	VBZ
cord-296347-fanlvxqs	568	3	,	,	,
cord-296347-fanlvxqs	568	4	as	as	IN
cord-296347-fanlvxqs	568	5	we	-PRON-	PRP
cord-296347-fanlvxqs	568	6	discussed	discuss	VBD
cord-296347-fanlvxqs	568	7	earlier	early	RBR
cord-296347-fanlvxqs	568	8	,	,	,
cord-296347-fanlvxqs	568	9	of	of	IN
cord-296347-fanlvxqs	568	10	crucial	crucial	JJ
cord-296347-fanlvxqs	568	11	importance	importance	NN
cord-296347-fanlvxqs	568	12	for	for	IN
cord-296347-fanlvxqs	568	13	NK	NK	NNP
cord-296347-fanlvxqs	568	14	cell	cell	NN
cord-296347-fanlvxqs	568	15	recognition	recognition	NN
cord-296347-fanlvxqs	568	16	.	.	.
cord-296347-fanlvxqs	569	1	SPP	SPP	NNP
cord-296347-fanlvxqs	569	2	is	be	VBZ
cord-296347-fanlvxqs	569	3	involved	involve	VBN
cord-296347-fanlvxqs	569	4	in	in	IN
cord-296347-fanlvxqs	569	5	processing	processing	NN
cord-296347-fanlvxqs	569	6	of	of	IN
cord-296347-fanlvxqs	569	7	the	the	DT
cord-296347-fanlvxqs	569	8	hepatitis	hepatitis	NN
cord-296347-fanlvxqs	569	9	C	C	NNP
cord-296347-fanlvxqs	569	10	virus	virus	NN
cord-296347-fanlvxqs	569	11	(	(	-LRB-
cord-296347-fanlvxqs	569	12	HCV	HCV	NNP
cord-296347-fanlvxqs	569	13	)	)	-RRB-
cord-296347-fanlvxqs	569	14	core	core	NN
cord-296347-fanlvxqs	569	15	protein	protein	NN
cord-296347-fanlvxqs	569	16	(	(	-LRB-
cord-296347-fanlvxqs	569	17	McLauchlan	McLauchlan	NNP
cord-296347-fanlvxqs	569	18	et	et	NNP
cord-296347-fanlvxqs	569	19	al	al	NNP
cord-296347-fanlvxqs	569	20	.	.	NNP
cord-296347-fanlvxqs	569	21	,	,	,
cord-296347-fanlvxqs	569	22	2002	2002	CD
cord-296347-fanlvxqs	569	23	)	)	-RRB-
cord-296347-fanlvxqs	569	24	.	.	.
cord-296347-fanlvxqs	570	1	HCV	HCV	NNP
cord-296347-fanlvxqs	570	2	is	be	VBZ
cord-296347-fanlvxqs	570	3	a	a	DT
cord-296347-fanlvxqs	570	4	single	single	RB
cord-296347-fanlvxqs	570	5	-	-	HYPH
cord-296347-fanlvxqs	570	6	stranded	strand	VBN
cord-296347-fanlvxqs	570	7	RNA	RNA	NNP
cord-296347-fanlvxqs	570	8	virus	virus	NN
cord-296347-fanlvxqs	570	9	with	with	IN
cord-296347-fanlvxqs	570	10	a	a	DT
cord-296347-fanlvxqs	570	11	single	single	JJ
cord-296347-fanlvxqs	570	12	open	open	JJ
cord-296347-fanlvxqs	570	13	reading	reading	NN
cord-296347-fanlvxqs	570	14	frame	frame	NN
cord-296347-fanlvxqs	570	15	encoding	encode	VBG
cord-296347-fanlvxqs	570	16	a	a	DT
cord-296347-fanlvxqs	570	17	large	large	JJ
cord-296347-fanlvxqs	570	18	polyprotein	polyprotein	NN
cord-296347-fanlvxqs	570	19	.	.	.
cord-296347-fanlvxqs	571	1	The	the	DT
cord-296347-fanlvxqs	571	2	N	n	CD
cord-296347-fanlvxqs	571	3	-	-	HYPH
cord-296347-fanlvxqs	571	4	terminal	terminal	JJ
cord-296347-fanlvxqs	571	5	portion	portion	NN
cord-296347-fanlvxqs	571	6	of	of	IN
cord-296347-fanlvxqs	571	7	the	the	DT
cord-296347-fanlvxqs	571	8	HCV	HCV	NNP
cord-296347-fanlvxqs	571	9	polyprotein	polyprotein	NN
cord-296347-fanlvxqs	571	10	encodes	encode	VBZ
cord-296347-fanlvxqs	571	11	the	the	DT
cord-296347-fanlvxqs	571	12	structural	structural	JJ
cord-296347-fanlvxqs	571	13	components	component	NNS
cord-296347-fanlvxqs	571	14	of	of	IN
cord-296347-fanlvxqs	571	15	the	the	DT
cord-296347-fanlvxqs	571	16	HCV	HCV	NNP
cord-296347-fanlvxqs	571	17	virion	virion	NN
cord-296347-fanlvxqs	571	18	,	,	,
cord-296347-fanlvxqs	571	19	the	the	DT
cord-296347-fanlvxqs	571	20	core	core	NN
cord-296347-fanlvxqs	571	21	protein	protein	NN
cord-296347-fanlvxqs	571	22	(	(	-LRB-
cord-296347-fanlvxqs	571	23	thought	think	VBN
cord-296347-fanlvxqs	571	24	to	to	TO
cord-296347-fanlvxqs	571	25	constitute	constitute	VB
cord-296347-fanlvxqs	571	26	the	the	DT
cord-296347-fanlvxqs	571	27	virion	virion	NN
cord-296347-fanlvxqs	571	28	capsid	capsid	NN
cord-296347-fanlvxqs	571	29	)	)	-RRB-
cord-296347-fanlvxqs	571	30	,	,	,
cord-296347-fanlvxqs	571	31	and	and	CC
cord-296347-fanlvxqs	571	32	the	the	DT
cord-296347-fanlvxqs	571	33	E1	E1	NNP
cord-296347-fanlvxqs	571	34	and	and	CC
cord-296347-fanlvxqs	571	35	E2	E2	NNP
cord-296347-fanlvxqs	571	36	envelope	envelope	NN
cord-296347-fanlvxqs	571	37	glycoproteins	glycoprotein	NNS
cord-296347-fanlvxqs	571	38	.	.	.
cord-296347-fanlvxqs	572	1	The	the	DT
cord-296347-fanlvxqs	572	2	mature	mature	JJ
cord-296347-fanlvxqs	572	3	structural	structural	JJ
cord-296347-fanlvxqs	572	4	components	component	NNS
cord-296347-fanlvxqs	572	5	of	of	IN
cord-296347-fanlvxqs	572	6	the	the	DT
cord-296347-fanlvxqs	572	7	HCV	HCV	NNP
cord-296347-fanlvxqs	572	8	virion	virion	NN
cord-296347-fanlvxqs	572	9	are	be	VBP
cord-296347-fanlvxqs	572	10	produced	produce	VBN
cord-296347-fanlvxqs	572	11	through	through	IN
cord-296347-fanlvxqs	572	12	a	a	DT
cord-296347-fanlvxqs	572	13	series	series	NN
cord-296347-fanlvxqs	572	14	of	of	IN
cord-296347-fanlvxqs	572	15	cleavage	cleavage	NN
cord-296347-fanlvxqs	572	16	events	event	NNS
cord-296347-fanlvxqs	572	17	catalyzed	catalyze	VBN
cord-296347-fanlvxqs	572	18	by	by	IN
cord-296347-fanlvxqs	572	19	cellular	cellular	JJ
cord-296347-fanlvxqs	572	20	proteases	protease	NNS
cord-296347-fanlvxqs	572	21	.	.	.
cord-296347-fanlvxqs	573	1	The	the	DT
cord-296347-fanlvxqs	573	2	core	core	NN
cord-296347-fanlvxqs	573	3	protein	protein	NN
cord-296347-fanlvxqs	573	4	is	be	VBZ
cord-296347-fanlvxqs	573	5	the	the	DT
cord-296347-fanlvxqs	573	6	most	most	JJS
cord-296347-fanlvxqs	573	7	N	n	CD
cord-296347-fanlvxqs	573	8	-	-	HYPH
cord-296347-fanlvxqs	573	9	terminal	terminal	JJ
cord-296347-fanlvxqs	573	10	portion	portion	NN
cord-296347-fanlvxqs	573	11	of	of	IN
cord-296347-fanlvxqs	573	12	the	the	DT
cord-296347-fanlvxqs	573	13	polyprotein	polyprotein	NN
cord-296347-fanlvxqs	573	14	and	and	CC
cord-296347-fanlvxqs	573	15	is	be	VBZ
cord-296347-fanlvxqs	573	16	followed	follow	VBN
cord-296347-fanlvxqs	573	17	by	by	IN
cord-296347-fanlvxqs	573	18	the	the	DT
cord-296347-fanlvxqs	573	19	signal	signal	JJ
cord-296347-fanlvxqs	573	20	sequence	sequence	NN
cord-296347-fanlvxqs	573	21	of	of	IN
cord-296347-fanlvxqs	573	22	the	the	DT
cord-296347-fanlvxqs	573	23	E1	e1	NN
cord-296347-fanlvxqs	573	24	envelope	envelope	NN
cord-296347-fanlvxqs	573	25	glycoprotein	glycoprotein	NN
cord-296347-fanlvxqs	573	26	.	.	.
cord-296347-fanlvxqs	574	1	The	the	DT
cord-296347-fanlvxqs	574	2	E1	e1	NN
cord-296347-fanlvxqs	574	3	signal	signal	NN
cord-296347-fanlvxqs	574	4	sequence	sequence	NN
cord-296347-fanlvxqs	574	5	targets	target	VBZ
cord-296347-fanlvxqs	574	6	the	the	DT
cord-296347-fanlvxqs	574	7	polyprotein	polyprotein	NN
cord-296347-fanlvxqs	574	8	to	to	IN
cord-296347-fanlvxqs	574	9	the	the	DT
cord-296347-fanlvxqs	574	10	ER	ER	NNP
cord-296347-fanlvxqs	574	11	membrane	membrane	NN
cord-296347-fanlvxqs	574	12	and	and	CC
cord-296347-fanlvxqs	574	13	induces	induce	VBZ
cord-296347-fanlvxqs	574	14	translocation	translocation	NN
cord-296347-fanlvxqs	574	15	of	of	IN
cord-296347-fanlvxqs	574	16	E1	e1	NN
cord-296347-fanlvxqs	574	17	into	into	IN
cord-296347-fanlvxqs	574	18	the	the	DT
cord-296347-fanlvxqs	574	19	ER	ER	NNP
cord-296347-fanlvxqs	574	20	lumen	lumen	NN
cord-296347-fanlvxqs	574	21	.	.	.
cord-296347-fanlvxqs	575	1	Cleavage	cleavage	NN
cord-296347-fanlvxqs	575	2	by	by	IN
cord-296347-fanlvxqs	575	3	signal	signal	NN
cord-296347-fanlvxqs	575	4	peptidase	peptidase	NN
cord-296347-fanlvxqs	575	5	liberates	liberate	VBZ
cord-296347-fanlvxqs	575	6	the	the	DT
cord-296347-fanlvxqs	575	7	N	n	CD
cord-296347-fanlvxqs	575	8	-	-	HYPH
cord-296347-fanlvxqs	575	9	terminal	terminal	JJ
cord-296347-fanlvxqs	575	10	end	end	NN
cord-296347-fanlvxqs	575	11	of	of	IN
cord-296347-fanlvxqs	575	12	E1	e1	NN
cord-296347-fanlvxqs	575	13	,	,	,
cord-296347-fanlvxqs	575	14	leaving	leave	VBG
cord-296347-fanlvxqs	575	15	the	the	DT
cord-296347-fanlvxqs	575	16	core	core	NN
cord-296347-fanlvxqs	575	17	protein	protein	NN
cord-296347-fanlvxqs	575	18	anchored	anchor	VBN
cord-296347-fanlvxqs	575	19	(	(	-LRB-
cord-296347-fanlvxqs	575	20	by	by	IN
cord-296347-fanlvxqs	575	21	the	the	DT
cord-296347-fanlvxqs	575	22	E1	E1	NNP
cord-296347-fanlvxqs	575	23	signal	signal	NN
cord-296347-fanlvxqs	575	24	peptide	peptide	NN
cord-296347-fanlvxqs	575	25	)	)	-RRB-
cord-296347-fanlvxqs	575	26	in	in	IN
cord-296347-fanlvxqs	575	27	the	the	DT
cord-296347-fanlvxqs	575	28	ER	ER	NNP
cord-296347-fanlvxqs	575	29	membrane	membrane	NN
cord-296347-fanlvxqs	575	30	.	.	.
cord-296347-fanlvxqs	576	1	SPP	spp	NN
cord-296347-fanlvxqs	576	2	-	-	HYPH
cord-296347-fanlvxqs	576	3	mediated	mediate	VBN
cord-296347-fanlvxqs	576	4	intramembrane	intramembrane	NNP
cord-296347-fanlvxqs	576	5	proteolysis	proteolysis	NN
cord-296347-fanlvxqs	576	6	of	of	IN
cord-296347-fanlvxqs	576	7	the	the	DT
cord-296347-fanlvxqs	576	8	E1	e1	NN
cord-296347-fanlvxqs	576	9	signal	signal	NN
cord-296347-fanlvxqs	576	10	sequence	sequence	NN
cord-296347-fanlvxqs	576	11	then	then	RB
cord-296347-fanlvxqs	576	12	results	result	VBZ
cord-296347-fanlvxqs	576	13	in	in	IN
cord-296347-fanlvxqs	576	14	release	release	NN
cord-296347-fanlvxqs	576	15	of	of	IN
cord-296347-fanlvxqs	576	16	the	the	DT
cord-296347-fanlvxqs	576	17	HCV	HCV	NNP
cord-296347-fanlvxqs	576	18	core	core	NN
cord-296347-fanlvxqs	576	19	protein	protein	NN
cord-296347-fanlvxqs	576	20	from	from	IN
cord-296347-fanlvxqs	576	21	the	the	DT
cord-296347-fanlvxqs	576	22	ER	ER	NNP
cord-296347-fanlvxqs	576	23	membrane	membrane	NN
cord-296347-fanlvxqs	576	24	,	,	,
cord-296347-fanlvxqs	576	25	thus	thus	RB
cord-296347-fanlvxqs	576	26	freeing	free	VBG
cord-296347-fanlvxqs	576	27	the	the	DT
cord-296347-fanlvxqs	576	28	mature	mature	JJ
cord-296347-fanlvxqs	576	29	core	core	NN
cord-296347-fanlvxqs	576	30	protein	protein	NN
cord-296347-fanlvxqs	576	31	for	for	IN
cord-296347-fanlvxqs	576	32	incorporation	incorporation	NN
cord-296347-fanlvxqs	576	33	into	into	IN
cord-296347-fanlvxqs	576	34	lipid	lipid	NN
cord-296347-fanlvxqs	576	35	droplets	droplet	NNS
cord-296347-fanlvxqs	576	36	(	(	-LRB-
cord-296347-fanlvxqs	576	37	Martoglio	Martoglio	NNP
cord-296347-fanlvxqs	576	38	and	and	CC
cord-296347-fanlvxqs	576	39	Golde	Golde	NNP
cord-296347-fanlvxqs	576	40	,	,	,
cord-296347-fanlvxqs	576	41	2003	2003	CD
cord-296347-fanlvxqs	576	42	)	)	-RRB-
cord-296347-fanlvxqs	576	43	.	.	.
cord-296347-fanlvxqs	577	1	SPP	spp	NN
cord-296347-fanlvxqs	577	2	-	-	HYPH
cord-296347-fanlvxqs	577	3	mediated	mediate	VBN
cord-296347-fanlvxqs	577	4	HCV	HCV	NNP
cord-296347-fanlvxqs	577	5	core	core	NN
cord-296347-fanlvxqs	577	6	protein	protein	NN
cord-296347-fanlvxqs	577	7	maturation	maturation	NN
cord-296347-fanlvxqs	577	8	and	and	CC
cord-296347-fanlvxqs	577	9	trafficking	trafficking	NN
cord-296347-fanlvxqs	577	10	to	to	IN
cord-296347-fanlvxqs	577	11	lipid	lipid	NN
cord-296347-fanlvxqs	577	12	droplets	droplet	NNS
cord-296347-fanlvxqs	577	13	and	and	CC
cord-296347-fanlvxqs	577	14	the	the	DT
cord-296347-fanlvxqs	577	15	outer	outer	JJ
cord-296347-fanlvxqs	577	16	mitochondrial	mitochondrial	NN
cord-296347-fanlvxqs	577	17	membrane	membrane	NN
cord-296347-fanlvxqs	577	18	may	may	MD
cord-296347-fanlvxqs	577	19	be	be	VB
cord-296347-fanlvxqs	577	20	critical	critical	JJ
cord-296347-fanlvxqs	577	21	for	for	IN
cord-296347-fanlvxqs	577	22	viral	viral	JJ
cord-296347-fanlvxqs	577	23	assembly	assembly	NN
cord-296347-fanlvxqs	577	24	and	and	CC
cord-296347-fanlvxqs	577	25	life	life	NN
cord-296347-fanlvxqs	577	26	cycle	cycle	NN
cord-296347-fanlvxqs	577	27	(	(	-LRB-
cord-296347-fanlvxqs	577	28	Ait	Ait	NNP
cord-296347-fanlvxqs	577	29	-	-	HYPH
cord-296347-fanlvxqs	577	30	Goughoulte	Goughoulte	NNP
cord-296347-fanlvxqs	577	31	et	et	NNP
cord-296347-fanlvxqs	577	32	al	al	NNP
cord-296347-fanlvxqs	577	33	.	.	NNP
cord-296347-fanlvxqs	577	34	,	,	,
cord-296347-fanlvxqs	577	35	2006	2006	CD
cord-296347-fanlvxqs	577	36	)	)	-RRB-
cord-296347-fanlvxqs	577	37	and	and	CC
cord-296347-fanlvxqs	577	38	may	may	MD
cord-296347-fanlvxqs	577	39	also	also	RB
cord-296347-fanlvxqs	577	40	affect	affect	VB
cord-296347-fanlvxqs	577	41	cellular	cellular	JJ
cord-296347-fanlvxqs	577	42	lipid	lipid	NN
cord-296347-fanlvxqs	577	43	metabolism	metabolism	NN
cord-296347-fanlvxqs	577	44	and	and	CC
cord-296347-fanlvxqs	577	45	apoptosis	apoptosis	NN
cord-296347-fanlvxqs	577	46	,	,	,
cord-296347-fanlvxqs	577	47	as	as	IN
cord-296347-fanlvxqs	577	48	HCV	HCV	NNP
cord-296347-fanlvxqs	577	49	core	core	NN
cord-296347-fanlvxqs	577	50	proteintransgenic	proteintransgenic	JJ
cord-296347-fanlvxqs	577	51	mice	mouse	NNS
cord-296347-fanlvxqs	577	52	display	display	VBP
cord-296347-fanlvxqs	577	53	liver	liver	NN
cord-296347-fanlvxqs	577	54	pathologies	pathology	NNS
cord-296347-fanlvxqs	577	55	,	,	,
cord-296347-fanlvxqs	577	56	mitochondrial	mitochondrial	JJ
cord-296347-fanlvxqs	577	57	injury	injury	NN
cord-296347-fanlvxqs	577	58	,	,	,
cord-296347-fanlvxqs	577	59	and	and	CC
cord-296347-fanlvxqs	577	60	enhanced	enhanced	JJ
cord-296347-fanlvxqs	577	61	oxidative	oxidative	JJ
cord-296347-fanlvxqs	577	62	stress	stress	NN
cord-296347-fanlvxqs	577	63	(	(	-LRB-
cord-296347-fanlvxqs	577	64	Chou	Chou	NNP
cord-296347-fanlvxqs	577	65	et	et	NNP
cord-296347-fanlvxqs	577	66	al	al	NNP
cord-296347-fanlvxqs	577	67	.	.	NNP
cord-296347-fanlvxqs	577	68	,	,	,
cord-296347-fanlvxqs	577	69	2005	2005	CD
cord-296347-fanlvxqs	577	70	;	;	:
cord-296347-fanlvxqs	578	1	Korenaga	Korenaga	NNP
cord-296347-fanlvxqs	578	2	et	et	NNP
cord-296347-fanlvxqs	578	3	al	al	NNP
cord-296347-fanlvxqs	578	4	.	.	.
cord-296347-fanlvxqs	579	1	,	,	,
cord-296347-fanlvxqs	579	2	2005	2005	CD
cord-296347-fanlvxqs	579	3	;	;	:
cord-296347-fanlvxqs	579	4	Meyer	Meyer	NNP
cord-296347-fanlvxqs	579	5	et	et	NNP
cord-296347-fanlvxqs	579	6	al	al	NNP
cord-296347-fanlvxqs	579	7	.	.	NNP
cord-296347-fanlvxqs	579	8	,	,	,
cord-296347-fanlvxqs	579	9	2005	2005	CD
cord-296347-fanlvxqs	580	1	;	;	:
cord-296347-fanlvxqs	580	2	Okuda	Okuda	NNP
cord-296347-fanlvxqs	580	3	et	et	NNP
cord-296347-fanlvxqs	580	4	al	al	NNP
cord-296347-fanlvxqs	580	5	.	.	NNP
cord-296347-fanlvxqs	580	6	,	,	,
cord-296347-fanlvxqs	580	7	2002	2002	CD
cord-296347-fanlvxqs	580	8	;	;	:
cord-296347-fanlvxqs	580	9	Omura	Omura	NNP
cord-296347-fanlvxqs	580	10	et	et	NNP
cord-296347-fanlvxqs	580	11	al	al	NNP
cord-296347-fanlvxqs	580	12	.	.	.
cord-296347-fanlvxqs	581	1	,	,	,
cord-296347-fanlvxqs	581	2	2005	2005	CD
cord-296347-fanlvxqs	581	3	;	;	:
cord-296347-fanlvxqs	581	4	Schwer	Schwer	NNP
cord-296347-fanlvxqs	581	5	et	et	NNP
cord-296347-fanlvxqs	581	6	al	al	NNP
cord-296347-fanlvxqs	581	7	.	.	NNP
cord-296347-fanlvxqs	581	8	,	,	,
cord-296347-fanlvxqs	581	9	2004	2004	CD
cord-296347-fanlvxqs	581	10	;	;	:
cord-296347-fanlvxqs	581	11	Suzuki	Suzuki	NNP
cord-296347-fanlvxqs	581	12	et	et	NNP
cord-296347-fanlvxqs	581	13	al	al	NNP
cord-296347-fanlvxqs	581	14	.	.	NNP
cord-296347-fanlvxqs	581	15	,	,	,
cord-296347-fanlvxqs	581	16	2005	2005	CD
cord-296347-fanlvxqs	581	17	)	)	-RRB-
cord-296347-fanlvxqs	581	18	.	.	.
cord-296347-fanlvxqs	582	1	SPP	spp	NN
cord-296347-fanlvxqs	582	2	-	-	HYPH
cord-296347-fanlvxqs	582	3	mediated	mediate	VBN
cord-296347-fanlvxqs	582	4	cleavage	cleavage	NN
cord-296347-fanlvxqs	582	5	of	of	IN
cord-296347-fanlvxqs	582	6	the	the	DT
cord-296347-fanlvxqs	582	7	HCV	HCV	NNP
cord-296347-fanlvxqs	582	8	core	core	NN
cord-296347-fanlvxqs	582	9	protein	protein	NN
cord-296347-fanlvxqs	582	10	may	may	MD
cord-296347-fanlvxqs	582	11	thus	thus	RB
cord-296347-fanlvxqs	582	12	modulate	modulate	VB
cord-296347-fanlvxqs	582	13	these	these	DT
cord-296347-fanlvxqs	582	14	important	important	JJ
cord-296347-fanlvxqs	582	15	cellular	cellular	JJ
cord-296347-fanlvxqs	582	16	functions	function	NNS
cord-296347-fanlvxqs	582	17	of	of	IN
cord-296347-fanlvxqs	582	18	HCV	HCV	NNP
cord-296347-fanlvxqs	582	19	.	.	.
cord-296347-fanlvxqs	583	1	SPP	SPP	NNP
cord-296347-fanlvxqs	583	2	may	may	MD
cord-296347-fanlvxqs	583	3	regulate	regulate	VB
cord-296347-fanlvxqs	583	4	the	the	DT
cord-296347-fanlvxqs	583	5	interaction	interaction	NN
cord-296347-fanlvxqs	583	6	of	of	IN
cord-296347-fanlvxqs	583	7	signal	signal	NN
cord-296347-fanlvxqs	583	8	peptide	peptide	NN
cord-296347-fanlvxqs	583	9	remnants	remnant	NNS
cord-296347-fanlvxqs	583	10	of	of	IN
cord-296347-fanlvxqs	583	11	HIV	HIV	NNP
cord-296347-fanlvxqs	583	12	gp160	gp160	NNP
cord-296347-fanlvxqs	583	13	envelope	envelope	NN
cord-296347-fanlvxqs	583	14	protein	protein	NN
cord-296347-fanlvxqs	583	15	and	and	CC
cord-296347-fanlvxqs	583	16	preprolactin	preprolactin	NNS
cord-296347-fanlvxqs	583	17	(	(	-LRB-
cord-296347-fanlvxqs	583	18	p	p	NN
cord-296347-fanlvxqs	583	19	-	-	:
cord-296347-fanlvxqs	583	20	Prl	Prl	NNP
cord-296347-fanlvxqs	583	21	)	)	-RRB-
cord-296347-fanlvxqs	583	22	with	with	IN
cord-296347-fanlvxqs	583	23	calmodulin	calmodulin	NN
cord-296347-fanlvxqs	583	24	.	.	.
cord-296347-fanlvxqs	584	1	A	a	DT
cord-296347-fanlvxqs	584	2	characteristic	characteristic	JJ
cord-296347-fanlvxqs	584	3	feature	feature	NN
cord-296347-fanlvxqs	584	4	of	of	IN
cord-296347-fanlvxqs	584	5	a	a	DT
cord-296347-fanlvxqs	584	6	signal	signal	JJ
cord-296347-fanlvxqs	584	7	sequence	sequence	NN
cord-296347-fanlvxqs	584	8	is	be	VBZ
cord-296347-fanlvxqs	584	9	its	-PRON-	PRP$
cord-296347-fanlvxqs	584	10	tripartite	tripartite	JJ
cord-296347-fanlvxqs	584	11	structure	structure	NN
cord-296347-fanlvxqs	584	12	:	:	:
cord-296347-fanlvxqs	584	13	a	a	DT
cord-296347-fanlvxqs	584	14	polar	polar	JJ
cord-296347-fanlvxqs	584	15	N	n	CD
cord-296347-fanlvxqs	584	16	-	-	HYPH
cord-296347-fanlvxqs	584	17	terminal	terminal	NN
cord-296347-fanlvxqs	584	18	n	n	CD
cord-296347-fanlvxqs	584	19	-	-	HYPH
cord-296347-fanlvxqs	584	20	region	region	NN
cord-296347-fanlvxqs	584	21	,	,	,
cord-296347-fanlvxqs	584	22	a	a	DT
cord-296347-fanlvxqs	584	23	hydrophobic	hydrophobic	JJ
cord-296347-fanlvxqs	584	24	core	core	NN
cord-296347-fanlvxqs	584	25	(	(	-LRB-
cord-296347-fanlvxqs	584	26	h	h	NN
cord-296347-fanlvxqs	584	27	-	-	HYPH
cord-296347-fanlvxqs	584	28	region	region	NN
cord-296347-fanlvxqs	584	29	)	)	-RRB-
cord-296347-fanlvxqs	584	30	of	of	IN
cord-296347-fanlvxqs	584	31	7	7	CD
cord-296347-fanlvxqs	584	32	-	-	SYM
cord-296347-fanlvxqs	584	33	15	15	CD
cord-296347-fanlvxqs	584	34	residues	residue	NNS
cord-296347-fanlvxqs	584	35	,	,	,
cord-296347-fanlvxqs	584	36	and	and	CC
cord-296347-fanlvxqs	584	37	a	a	DT
cord-296347-fanlvxqs	584	38	polar	polar	JJ
cord-296347-fanlvxqs	584	39	C	c	NN
cord-296347-fanlvxqs	584	40	-	-	HYPH
cord-296347-fanlvxqs	584	41	terminal	terminal	NN
cord-296347-fanlvxqs	584	42	c	c	NN
cord-296347-fanlvxqs	584	43	-	-	HYPH
cord-296347-fanlvxqs	584	44	region	region	NN
cord-296347-fanlvxqs	584	45	that	that	WDT
cord-296347-fanlvxqs	584	46	contains	contain	VBZ
cord-296347-fanlvxqs	584	47	the	the	DT
cord-296347-fanlvxqs	584	48	consensus	consensus	NN
cord-296347-fanlvxqs	584	49	sequence	sequence	NN
cord-296347-fanlvxqs	584	50	for	for	IN
cord-296347-fanlvxqs	584	51	signal	signal	NN
cord-296347-fanlvxqs	584	52	peptide	peptide	NN
cord-296347-fanlvxqs	584	53	cleava	cleava	NNP
cord-296347-fanlvxqs	584	54	ge	ge	NNP
cord-296347-fanlvxqs	585	1	(	(	-LRB-
cord-296347-fanlvxqs	585	2	von	von	NNP
cord-296347-fanlvxqs	585	3	He	He	NNP
cord-296347-fanlvxqs	585	4	ijne	ijne	NN
cord-296347-fanlvxqs	585	5	,	,	,
cord-296347-fanlvxqs	585	6	1985	1985	CD
cord-296347-fanlvxqs	585	7	)	)	-RRB-
cord-296347-fanlvxqs	585	8	.	.	.
cord-296347-fanlvxqs	586	1	The	the	DT
cord-296347-fanlvxqs	586	2	nregion	nregion	NN
cord-296347-fanlvxqs	586	3	of	of	IN
cord-296347-fanlvxqs	586	4	most	most	JJS
cord-296347-fanlvxqs	586	5	signal	signal	NN
cord-296347-fanlvxqs	586	6	sequen	sequen	FW
cord-296347-fanlvxqs	586	7	ces	ces	NNP
cord-296347-fanlvxqs	586	8	comprise	comprise	VBP
cord-296347-fanlvxqs	586	9	s	s	NNP
cord-296347-fanlvxqs	586	10	only	only	RB
cord-296347-fanlvxqs	586	11	a	a	DT
cord-296347-fanlvxqs	586	12	few	few	JJ
cord-296347-fanlvxqs	586	13	residues	residue	NNS
cord-296347-fanlvxqs	586	14	.	.	.
cord-296347-fanlvxqs	587	1	However	however	RB
cord-296347-fanlvxqs	587	2	,	,	,
cord-296347-fanlvxqs	587	3	some	some	DT
cord-296347-fanlvxqs	587	4	signal	signal	NN
cord-296347-fanlvxqs	587	5	sequences	sequence	NNS
cord-296347-fanlvxqs	587	6	have	have	VBP
cord-296347-fanlvxqs	587	7	extended	extend	VBN
cord-296347-fanlvxqs	587	8	n	n	NNS
cord-296347-fanlvxqs	587	9	-	-	NNS
cord-296347-fanlvxqs	587	10	regions	region	NNS
cord-296347-fanlvxqs	587	11	of	of	IN
cord-296347-fanlvxqs	587	12	up	up	IN
cord-296347-fanlvxqs	587	13	to	to	TO
cord-296347-fanlvxqs	587	14	150	150	CD
cord-296347-fanlvxqs	587	15	residues	residue	NNS
cord-296347-fanlvxqs	587	16	.	.	.
cord-296347-fanlvxqs	588	1	The	the	DT
cord-296347-fanlvxqs	588	2	function	function	NN
cord-296347-fanlvxqs	588	3	of	of	IN
cord-296347-fanlvxqs	588	4	such	such	JJ
cord-296347-fanlvxqs	588	5	long	long	JJ
cord-296347-fanlvxqs	588	6	n	n	NN
cord-296347-fanlvxqs	588	7	-	-	HYPH
cord-296347-fanlvxqs	588	8	regions	region	NNS
cord-296347-fanlvxqs	588	9	is	be	VBZ
cord-296347-fanlvxqs	588	10	not	not	RB
cord-296347-fanlvxqs	588	11	known	know	VBN
cord-296347-fanlvxqs	588	12	.	.	.
cord-296347-fanlvxqs	589	1	Both	both	CC
cord-296347-fanlvxqs	589	2	the	the	DT
cord-296347-fanlvxqs	589	3	p	p	NN
cord-296347-fanlvxqs	589	4	-	-	:
cord-296347-fanlvxqs	589	5	Prl	Prl	NNP
cord-296347-fanlvxqs	589	6	and	and	CC
cord-296347-fanlvxqs	589	7	the	the	DT
cord-296347-fanlvxqs	589	8	gp160	gp160	NNP
cord-296347-fanlvxqs	589	9	signal	signal	NN
cord-296347-fanlvxqs	589	10	sequence	sequence	NN
cord-296347-fanlvxqs	589	11	have	have	VBP
cord-296347-fanlvxqs	589	12	an	an	DT
cord-296347-fanlvxqs	589	13	extended	extended	JJ
cord-296347-fanlvxqs	589	14	basic	basic	JJ
cord-296347-fanlvxqs	589	15	n	n	NN
cord-296347-fanlvxqs	589	16	-	-	HYPH
cord-296347-fanlvxqs	589	17	region	region	NN
cord-296347-fanlvxqs	589	18	that	that	WDT
cord-296347-fanlvxqs	589	19	can	can	MD
cord-296347-fanlvxqs	589	20	potentially	potentially	RB
cord-296347-fanlvxqs	589	21	form	form	VB
cord-296347-fanlvxqs	589	22	a	a	DT
cord-296347-fanlvxqs	589	23	basic	basic	JJ
cord-296347-fanlvxqs	589	24	amphiphilic	amphiphilic	JJ
cord-296347-fanlvxqs	589	25	alpha	alpha	NN
cord-296347-fanlvxqs	589	26	-	-	HYPH
cord-296347-fanlvxqs	589	27	helix	helix	NN
cord-296347-fanlvxqs	589	28	,	,	,
cord-296347-fanlvxqs	589	29	a	a	DT
cord-296347-fanlvxqs	589	30	feature	feature	NN
cord-296347-fanlvxqs	589	31	of	of	IN
cord-296347-fanlvxqs	589	32	CaM	cam	NN
cord-296347-fanlvxqs	589	33	-	-	HYPH
cord-296347-fanlvxqs	589	34	binding	bind	VBG
cord-296347-fanlvxqs	589	35	domains	domain	NNS
cord-296347-fanlvxqs	589	36	(	(	-LRB-
cord-296347-fanlvxqs	589	37	O'Neil	O'Neil	NNP
cord-296347-fanlvxqs	589	38	and	and	CC
cord-296347-fanlvxqs	589	39	DeGrado	DeGrado	NNP
cord-296347-fanlvxqs	589	40	,	,	,
cord-296347-fanlvxqs	589	41	1990	1990	CD
cord-296347-fanlvxqs	589	42	)	)	-RRB-
cord-296347-fanlvxqs	589	43	,	,	,
cord-296347-fanlvxqs	589	44	not	not	RB
cord-296347-fanlvxqs	589	45	found	find	VBN
cord-296347-fanlvxqs	589	46	in	in	IN
cord-296347-fanlvxqs	589	47	the	the	DT
cord-296347-fanlvxqs	589	48	majority	majority	NN
cord-296347-fanlvxqs	589	49	of	of	IN
cord-296347-fanlvxqs	589	50	signal	signal	NN
cord-296347-fanlvxqs	589	51	sequences	sequence	NNS
cord-296347-fanlvxqs	589	52	.	.	.
cord-296347-fanlvxqs	590	1	SPP	spp	NN
cord-296347-fanlvxqs	590	2	-	-	HYPH
cord-296347-fanlvxqs	590	3	mediated	mediate	VBN
cord-296347-fanlvxqs	590	4	cleavage	cleavage	NN
cord-296347-fanlvxqs	590	5	releases	release	VBZ
cord-296347-fanlvxqs	590	6	this	this	DT
cord-296347-fanlvxqs	590	7	CaM	cam	NN
cord-296347-fanlvxqs	590	8	-	-	HYPH
cord-296347-fanlvxqs	590	9	binding	bind	VBG
cord-296347-fanlvxqs	590	10	domain	domain	NN
cord-296347-fanlvxqs	590	11	on	on	IN
cord-296347-fanlvxqs	590	12	the	the	DT
cord-296347-fanlvxqs	590	13	N	n	CD
cord-296347-fanlvxqs	590	14	-	-	HYPH
cord-296347-fanlvxqs	590	15	terminal	terminal	NN
cord-296347-fanlvxqs	590	16	fragment	fragment	NN
cord-296347-fanlvxqs	590	17	of	of	IN
cord-296347-fanlvxqs	590	18	the	the	DT
cord-296347-fanlvxqs	590	19	p	p	NN
cord-296347-fanlvxqs	590	20	-	-	:
cord-296347-fanlvxqs	590	21	Prl	Prl	NNP
cord-296347-fanlvxqs	590	22	and	and	CC
cord-296347-fanlvxqs	590	23	gp160	gp160	NN
cord-296347-fanlvxqs	590	24	signal	signal	NN
cord-296347-fanlvxqs	590	25	peptides	peptide	NNS
cord-296347-fanlvxqs	590	26	into	into	IN
cord-296347-fanlvxqs	590	27	the	the	DT
cord-296347-fanlvxqs	590	28	cytosol	cytosol	NN
cord-296347-fanlvxqs	590	29	.	.	.
cord-296347-fanlvxqs	591	1	The	the	DT
cord-296347-fanlvxqs	591	2	functional	functional	JJ
cord-296347-fanlvxqs	591	3	and	and	CC
cord-296347-fanlvxqs	591	4	physiological	physiological	JJ
cord-296347-fanlvxqs	591	5	significance	significance	NN
cord-296347-fanlvxqs	591	6	of	of	IN
cord-296347-fanlvxqs	591	7	an	an	DT
cord-296347-fanlvxqs	591	8	interaction	interaction	NN
cord-296347-fanlvxqs	591	9	between	between	IN
cord-296347-fanlvxqs	591	10	the	the	DT
cord-296347-fanlvxqs	591	11	p	p	NN
cord-296347-fanlvxqs	591	12	-	-	:
cord-296347-fanlvxqs	591	13	Prl	Prl	NNP
cord-296347-fanlvxqs	591	14	and	and	CC
cord-296347-fanlvxqs	591	15	p	p	NN
cord-296347-fanlvxqs	591	16	-	-	HYPH
cord-296347-fanlvxqs	591	17	gp160	gp160	NN
cord-296347-fanlvxqs	591	18	signal	signal	NN
cord-296347-fanlvxqs	591	19	peptide	peptide	NN
cord-296347-fanlvxqs	591	20	fragments	fragment	NNS
cord-296347-fanlvxqs	591	21	that	that	WDT
cord-296347-fanlvxqs	591	22	are	be	VBP
cord-296347-fanlvxqs	591	23	released	release	VBN
cord-296347-fanlvxqs	591	24	into	into	IN
cord-296347-fanlvxqs	591	25	the	the	DT
cord-296347-fanlvxqs	591	26	cytosol	cytosol	NN
cord-296347-fanlvxqs	591	27	and	and	CC
cord-296347-fanlvxqs	591	28	calmodulin	calmodulin	NNP
cord-296347-fanlvxqs	591	29	(	(	-LRB-
cord-296347-fanlvxqs	591	30	CaM	CaM	NNP
cord-296347-fanlvxqs	591	31	)	)	-RRB-
cord-296347-fanlvxqs	591	32	could	could	MD
cord-296347-fanlvxqs	591	33	be	be	VB
cord-296347-fanlvxqs	591	34	due	due	JJ
cord-296347-fanlvxqs	591	35	to	to	IN
cord-296347-fanlvxqs	591	36	a	a	DT
cord-296347-fanlvxqs	591	37	regulatory	regulatory	JJ
cord-296347-fanlvxqs	591	38	function	function	NN
cord-296347-fanlvxqs	591	39	of	of	IN
cord-296347-fanlvxqs	591	40	the	the	DT
cord-296347-fanlvxqs	591	41	signal	signal	JJ
cord-296347-fanlvxqs	591	42	peptide	peptide	NN
cord-296347-fanlvxqs	591	43	fragments	fragment	NNS
cord-296347-fanlvxqs	591	44	.	.	.
cord-296347-fanlvxqs	592	1	CaM	cam	NN
cord-296347-fanlvxqs	592	2	-	-	HYPH
cord-296347-fanlvxqs	592	3	dependent	dependent	JJ
cord-296347-fanlvxqs	592	4	processes	process	NNS
cord-296347-fanlvxqs	592	5	could	could	MD
cord-296347-fanlvxqs	592	6	be	be	VB
cord-296347-fanlvxqs	592	7	enhanced	enhance	VBN
cord-296347-fanlvxqs	592	8	or	or	CC
cord-296347-fanlvxqs	592	9	inhibited	inhibit	VBN
cord-296347-fanlvxqs	592	10	depending	depend	VBG
cord-296347-fanlvxqs	592	11	on	on	IN
cord-296347-fanlvxqs	592	12	the	the	DT
cord-296347-fanlvxqs	592	13	amounts	amount	NNS
cord-296347-fanlvxqs	592	14	of	of	IN
cord-296347-fanlvxqs	592	15	CaM	cam	NN
cord-296347-fanlvxqs	592	16	-	-	HYPH
cord-296347-fanlvxqs	592	17	binding	bind	VBG
cord-296347-fanlvxqs	592	18	signal	signal	NN
cord-296347-fanlvxqs	592	19	peptide	peptide	NN
cord-296347-fanlvxqs	592	20	fragments	fragment	NNS
cord-296347-fanlvxqs	592	21	generated	generate	VBN
cord-296347-fanlvxqs	592	22	and	and	CC
cord-296347-fanlvxqs	592	23	released	release	VBN
cord-296347-fanlvxqs	592	24	into	into	IN
cord-296347-fanlvxqs	592	25	the	the	DT
cord-296347-fanlvxqs	592	26	cytosol	cytosol	NN
cord-296347-fanlvxqs	592	27	(	(	-LRB-
cord-296347-fanlvxqs	592	28	Martoglio	Martoglio	NNP
cord-296347-fanlvxqs	592	29	et	et	NNP
cord-296347-fanlvxqs	592	30	al	al	NNP
cord-296347-fanlvxqs	592	31	.	.	NNP
cord-296347-fanlvxqs	592	32	,	,	,
cord-296347-fanlvxqs	592	33	1997	1997	CD
cord-296347-fanlvxqs	592	34	)	)	-RRB-
cord-296347-fanlvxqs	592	35	.	.	.
cord-296347-fanlvxqs	593	1	The	the	DT
cord-296347-fanlvxqs	593	2	SPP	SPP	NNP
cord-296347-fanlvxqs	593	3	orthologues	orthologue	NNS
cord-296347-fanlvxqs	593	4	in	in	IN
cord-296347-fanlvxqs	593	5	Drosophila	Drosophila	NNP
cord-296347-fanlvxqs	593	6	melanogaster	melanogaster	NN
cord-296347-fanlvxqs	593	7	,	,	,
cord-296347-fanlvxqs	593	8	Spp	Spp	NNP
cord-296347-fanlvxqs	593	9	,	,	,
cord-296347-fanlvxqs	593	10	and	and	CC
cord-296347-fanlvxqs	593	11	in	in	IN
cord-296347-fanlvxqs	593	12	Caenorhabditis	Caenorhabditis	NNP
cord-296347-fanlvxqs	593	13	elegans	elegan	NNS
cord-296347-fanlvxqs	593	14	,	,	,
cord-296347-fanlvxqs	593	15	Imp-2	Imp-2	NNP
cord-296347-fanlvxqs	593	16	,	,	,
cord-296347-fanlvxqs	593	17	play	play	VB
cord-296347-fanlvxqs	593	18	an	an	DT
cord-296347-fanlvxqs	593	19	essential	essential	JJ
cord-296347-fanlvxqs	593	20	role	role	NN
cord-296347-fanlvxqs	593	21	in	in	IN
cord-296347-fanlvxqs	593	22	development	development	NN
cord-296347-fanlvxqs	593	23	:	:	:
cord-296347-fanlvxqs	594	1	SPP	spp	NN
cord-296347-fanlvxqs	594	2	protease	protease	NN
cord-296347-fanlvxqs	594	3	activity	activity	NN
cord-296347-fanlvxqs	594	4	seems	seem	VBZ
cord-296347-fanlvxqs	594	5	to	to	TO
cord-296347-fanlvxqs	594	6	be	be	VB
cord-296347-fanlvxqs	594	7	essential	essential	JJ
cord-296347-fanlvxqs	594	8	for	for	IN
cord-296347-fanlvxqs	594	9	larval	larval	JJ
cord-296347-fanlvxqs	594	10	development	development	NN
cord-296347-fanlvxqs	594	11	both	both	DT
cord-296347-fanlvxqs	594	12	in	in	IN
cord-296347-fanlvxqs	594	13	the	the	DT
cord-296347-fanlvxqs	594	14	fly	fly	NN
cord-296347-fanlvxqs	594	15	and	and	CC
cord-296347-fanlvxqs	594	16	in	in	IN
cord-296347-fanlvxqs	594	17	the	the	DT
cord-296347-fanlvxqs	594	18	nematode	nematode	NN
cord-296347-fanlvxqs	594	19	(	(	-LRB-
cord-296347-fanlvxqs	594	20	Casso	Casso	NNP
cord-296347-fanlvxqs	594	21	et	et	NNP
cord-296347-fanlvxqs	594	22	al	al	NNP
cord-296347-fanlvxqs	594	23	.	.	NNP
cord-296347-fanlvxqs	594	24	,	,	,
cord-296347-fanlvxqs	594	25	2005	2005	CD
cord-296347-fanlvxqs	594	26	;	;	:
cord-296347-fanlvxqs	594	27	Grigorenko	Grigorenko	NNP
cord-296347-fanlvxqs	594	28	et	et	NNP
cord-296347-fanlvxqs	594	29	al	al	NNP
cord-296347-fanlvxqs	594	30	.	.	NNP
cord-296347-fanlvxqs	594	31	,	,	,
cord-296347-fanlvxqs	594	32	2004	2004	CD
cord-296347-fanlvxqs	594	33	)	)	-RRB-
cord-296347-fanlvxqs	594	34	.	.	.
cord-296347-fanlvxqs	595	1	Although	although	IN
cord-296347-fanlvxqs	595	2	the	the	DT
cord-296347-fanlvxqs	595	3	mechanism	mechanism	NN
cord-296347-fanlvxqs	595	4	by	by	IN
cord-296347-fanlvxqs	595	5	which	which	WDT
cord-296347-fanlvxqs	595	6	SPP	spp	NN
cord-296347-fanlvxqs	595	7	mutations	mutation	NNS
cord-296347-fanlvxqs	595	8	impairs	impair	VBZ
cord-296347-fanlvxqs	595	9	developmental	developmental	JJ
cord-296347-fanlvxqs	595	10	processes	process	NNS
cord-296347-fanlvxqs	595	11	in	in	IN
cord-296347-fanlvxqs	595	12	the	the	DT
cord-296347-fanlvxqs	595	13	fly	fly	NN
cord-296347-fanlvxqs	595	14	is	be	VBZ
cord-296347-fanlvxqs	595	15	currently	currently	RB
cord-296347-fanlvxqs	595	16	unknown	unknown	JJ
cord-296347-fanlvxqs	595	17	,	,	,
cord-296347-fanlvxqs	595	18	in	in	IN
cord-296347-fanlvxqs	595	19	C.	C.	NNP
cord-296347-fanlvxqs	595	20	elegans	elegan	VBZ
cord-296347-fanlvxqs	595	21	the	the	DT
cord-296347-fanlvxqs	595	22	molting	molting	NN
cord-296347-fanlvxqs	595	23	defect	defect	NN
cord-296347-fanlvxqs	595	24	induced	induce	VBN
cord-296347-fanlvxqs	595	25	by	by	IN
cord-296347-fanlvxqs	595	26	imp-2	imp-2	DT
cord-296347-fanlvxqs	595	27	deficiency	deficiency	NN
cord-296347-fanlvxqs	595	28	was	be	VBD
cord-296347-fanlvxqs	595	29	mimicked	mimic	VBN
cord-296347-fanlvxqs	595	30	by	by	IN
cord-296347-fanlvxqs	595	31	cholesterol	cholesterol	NN
cord-296347-fanlvxqs	595	32	depletion	depletion	NN
cord-296347-fanlvxqs	595	33	and	and	CC
cord-296347-fanlvxqs	595	34	by	by	IN
cord-296347-fanlvxqs	595	35	deficiency	deficiency	NN
cord-296347-fanlvxqs	595	36	in	in	IN
cord-296347-fanlvxqs	595	37	Irp-1	Irp-1	NNP
cord-296347-fanlvxqs	595	38	,	,	,
cord-296347-fanlvxqs	595	39	a	a	DT
cord-296347-fanlvxqs	595	40	homologue	homologue	NN
cord-296347-fanlvxqs	595	41	of	of	IN
cord-296347-fanlvxqs	595	42	mammalian	mammalian	JJ
cord-296347-fanlvxqs	595	43	lipoprotein	lipoprotein	NN
cord-296347-fanlvxqs	595	44	receptor	receptor	NN
cord-296347-fanlvxqs	595	45	-	-	HYPH
cord-296347-fanlvxqs	595	46	related	relate	VBN
cord-296347-fanlvxqs	595	47	protein	protein	NN
cord-296347-fanlvxqs	595	48	(	(	-LRB-
cord-296347-fanlvxqs	595	49	LRP	LRP	NNP
cord-296347-fanlvxqs	595	50	)	)	-RRB-
cord-296347-fanlvxqs	595	51	receptors	receptor	NNS
cord-296347-fanlvxqs	595	52	suggesting	suggest	VBG
cord-296347-fanlvxqs	595	53	a	a	DT
cord-296347-fanlvxqs	595	54	role	role	NN
cord-296347-fanlvxqs	595	55	in	in	IN
cord-296347-fanlvxqs	595	56	cholesterol	cholesterol	NN
cord-296347-fanlvxqs	595	57	and	and	CC
cord-296347-fanlvxqs	595	58	lipid	lipid	NN
cord-296347-fanlvxqs	595	59	metabolism	metabolism	NN
cord-296347-fanlvxqs	595	60	(	(	-LRB-
cord-296347-fanlvxqs	595	61	Grigorenko	Grigorenko	NNP
cord-296347-fanlvxqs	595	62	et	et	NNP
cord-296347-fanlvxqs	595	63	al	al	NNP
cord-296347-fanlvxqs	595	64	.	.	NNP
cord-296347-fanlvxqs	595	65	,	,	,
cord-296347-fanlvxqs	595	66	2004	2004	CD
cord-296347-fanlvxqs	595	67	)	)	-RRB-
cord-296347-fanlvxqs	595	68	.	.	.
cord-296347-fanlvxqs	596	1	The	the	DT
cord-296347-fanlvxqs	596	2	possibility	possibility	NN
cord-296347-fanlvxqs	596	3	of	of	IN
cord-296347-fanlvxqs	596	4	a	a	DT
cord-296347-fanlvxqs	596	5	role	role	NN
cord-296347-fanlvxqs	596	6	for	for	IN
cord-296347-fanlvxqs	596	7	SPP	SPP	NNP
cord-296347-fanlvxqs	596	8	in	in	IN
cord-296347-fanlvxqs	596	9	ER	ER	NNP
cord-296347-fanlvxqs	596	10	quality	quality	NN
cord-296347-fanlvxqs	596	11	control	control	NN
cord-296347-fanlvxqs	596	12	was	be	VBD
cord-296347-fanlvxqs	596	13	first	first	RB
cord-296347-fanlvxqs	596	14	advanced	advance	VBN
cord-296347-fanlvxqs	596	15	by	by	IN
cord-296347-fanlvxqs	596	16	High	High	NNP
cord-296347-fanlvxqs	596	17	and	and	CC
cord-296347-fanlvxqs	596	18	colleagues	colleague	NNS
cord-296347-fanlvxqs	596	19	,	,	,
cord-296347-fanlvxqs	596	20	who	who	WP
cord-296347-fanlvxqs	596	21	reported	report	VBD
cord-296347-fanlvxqs	596	22	an	an	DT
cord-296347-fanlvxqs	596	23	association	association	NN
cord-296347-fanlvxqs	596	24	between	between	IN
cord-296347-fanlvxqs	596	25	SPP	SPP	NNP
cord-296347-fanlvxqs	596	26	and	and	CC
cord-296347-fanlvxqs	596	27	a	a	DT
cord-296347-fanlvxqs	596	28	truncated	truncated	JJ
cord-296347-fanlvxqs	596	29	version	version	NN
cord-296347-fanlvxqs	596	30	of	of	IN
cord-296347-fanlvxqs	596	31	a	a	DT
cord-296347-fanlvxqs	596	32	polytopic	polytopic	JJ
cord-296347-fanlvxqs	596	33	ER	ER	NNP
cord-296347-fanlvxqs	596	34	protein	protein	NN
cord-296347-fanlvxqs	596	35	(	(	-LRB-
cord-296347-fanlvxqs	596	36	opsin	opsin	NN
cord-296347-fanlvxqs	596	37	)	)	-RRB-
cord-296347-fanlvxqs	596	38	in	in	IN
cord-296347-fanlvxqs	596	39	an	an	DT
cord-296347-fanlvxqs	596	40	in	in	FW
cord-296347-fanlvxqs	596	41	vitro	vitro	FW
cord-296347-fanlvxqs	596	42	system	system	NN
cord-296347-fanlvxqs	596	43	(	(	-LRB-
cord-296347-fanlvxqs	596	44	Crawshaw	Crawshaw	NNP
cord-296347-fanlvxqs	596	45	et	et	NNP
cord-296347-fanlvxqs	596	46	al	al	NNP
cord-296347-fanlvxqs	596	47	.	.	NNP
cord-296347-fanlvxqs	596	48	,	,	,
cord-296347-fanlvxqs	596	49	2004	2004	CD
cord-296347-fanlvxqs	596	50	)	)	-RRB-
cord-296347-fanlvxqs	596	51	and	and	CC
cord-296347-fanlvxqs	596	52	proposed	propose	VBD
cord-296347-fanlvxqs	596	53	SPP	SPP	NNS
cord-296347-fanlvxqs	596	54	to	to	TO
cord-296347-fanlvxqs	596	55	be	be	VB
cord-296347-fanlvxqs	596	56	implicated	implicate	VBN
cord-296347-fanlvxqs	596	57	in	in	IN
cord-296347-fanlvxqs	596	58	the	the	DT
cord-296347-fanlvxqs	596	59	recognition	recognition	NN
cord-296347-fanlvxqs	596	60	of	of	IN
cord-296347-fanlvxqs	596	61	misassembled	misassembled	NNP
cord-296347-fanlvxqs	596	62	transmembrane	transmembrane	NN
cord-296347-fanlvxqs	596	63	domains	domain	NNS
cord-296347-fanlvxqs	596	64	during	during	IN
cord-296347-fanlvxqs	596	65	membrane	membrane	NN
cord-296347-fanlvxqs	596	66	protein	protein	NN
cord-296347-fanlvxqs	596	67	quality	quality	NN
cord-296347-fanlvxqs	596	68	control	control	NN
cord-296347-fanlvxqs	596	69	at	at	IN
cord-296347-fanlvxqs	596	70	the	the	DT
cord-296347-fanlvxqs	596	71	ER	ER	NNP
cord-296347-fanlvxqs	596	72	.	.	.
cord-296347-fanlvxqs	597	1	US2-mediated	us2-mediate	VBN
cord-296347-fanlvxqs	597	2	dislocation	dislocation	NN
cord-296347-fanlvxqs	597	3	of	of	IN
cord-296347-fanlvxqs	597	4	class	class	NN
cord-296347-fanlvxqs	598	1	I	-PRON-	PRP
cord-296347-fanlvxqs	598	2	MHC	MHC	NNP
cord-296347-fanlvxqs	598	3	HC	HC	NNP
cord-296347-fanlvxqs	598	4	molecules	molecule	NNS
cord-296347-fanlvxqs	598	5	presents	present	VBZ
cord-296347-fanlvxqs	598	6	the	the	DT
cord-296347-fanlvxqs	598	7	first	first	JJ
cord-296347-fanlvxqs	598	8	functional	functional	JJ
cord-296347-fanlvxqs	598	9	evidence	evidence	NN
cord-296347-fanlvxqs	598	10	of	of	IN
cord-296347-fanlvxqs	598	11	such	such	PDT
cord-296347-fanlvxqs	598	12	a	a	DT
cord-296347-fanlvxqs	598	13	role	role	NN
cord-296347-fanlvxqs	598	14	for	for	IN
cord-296347-fanlvxqs	598	15	the	the	DT
cord-296347-fanlvxqs	598	16	intramembranecleaving	intramembranecleave	VBG
cord-296347-fanlvxqs	598	17	protease	protease	NN
cord-296347-fanlvxqs	598	18	SPP	SPP	NNS
cord-296347-fanlvxqs	598	19	.	.	.
cord-296347-fanlvxqs	599	1	The	the	DT
cord-296347-fanlvxqs	599	2	US2	US2	NNP
cord-296347-fanlvxqs	599	3	tail	tail	NN
cord-296347-fanlvxqs	599	4	is	be	VBZ
cord-296347-fanlvxqs	599	5	necessary	necessary	JJ
cord-296347-fanlvxqs	599	6	and	and	CC
cord-296347-fanlvxqs	599	7	sufficient	sufficient	JJ
cord-296347-fanlvxqs	599	8	to	to	TO
cord-296347-fanlvxqs	599	9	recruit	recruit	VB
cord-296347-fanlvxqs	599	10	SPP	SPP	NNP
cord-296347-fanlvxqs	599	11	,	,	,
cord-296347-fanlvxqs	599	12	and	and	CC
cord-296347-fanlvxqs	599	13	structural	structural	JJ
cord-296347-fanlvxqs	599	14	predictions	prediction	NNS
cord-296347-fanlvxqs	599	15	suggest	suggest	VBP
cord-296347-fanlvxqs	599	16	that	that	IN
cord-296347-fanlvxqs	599	17	the	the	DT
cord-296347-fanlvxqs	599	18	US2	US2	NNP
cord-296347-fanlvxqs	599	19	tail	tail	NN
cord-296347-fanlvxqs	599	20	suggests	suggest	VBZ
cord-296347-fanlvxqs	599	21	may	may	MD
cord-296347-fanlvxqs	599	22	adopt	adopt	VB
cord-296347-fanlvxqs	599	23	a	a	DT
cord-296347-fanlvxqs	599	24	3	3	CD
cord-296347-fanlvxqs	599	25	10	10	CD
cord-296347-fanlvxqs	599	26	helical	helical	JJ
cord-296347-fanlvxqs	599	27	conformation	conformation	NN
cord-296347-fanlvxqs	599	28	that	that	WDT
cord-296347-fanlvxqs	599	29	could	could	MD
cord-296347-fanlvxqs	599	30	form	form	VB
cord-296347-fanlvxqs	599	31	a	a	DT
cord-296347-fanlvxqs	599	32	protein	protein	NN
cord-296347-fanlvxqs	599	33	-	-	HYPH
cord-296347-fanlvxqs	599	34	protein	protein	NN
cord-296347-fanlvxqs	599	35	interaction	interaction	NN
cord-296347-fanlvxqs	599	36	domain	domain	NN
cord-296347-fanlvxqs	599	37	(	(	-LRB-
cord-296347-fanlvxqs	599	38	Oresic	Oresic	NNP
cord-296347-fanlvxqs	599	39	et	et	NNP
cord-296347-fanlvxqs	599	40	al	al	NNP
cord-296347-fanlvxqs	599	41	.	.	NNP
cord-296347-fanlvxqs	599	42	,	,	,
cord-296347-fanlvxqs	599	43	2006	2006	CD
cord-296347-fanlvxqs	599	44	)	)	-RRB-
cord-296347-fanlvxqs	599	45	.	.	.
cord-296347-fanlvxqs	600	1	SPP	SPP	NNP
cord-296347-fanlvxqs	600	2	is	be	VBZ
cord-296347-fanlvxqs	600	3	crucial	crucial	JJ
cord-296347-fanlvxqs	600	4	for	for	IN
cord-296347-fanlvxqs	600	5	dislocation	dislocation	NN
cord-296347-fanlvxqs	600	6	by	by	IN
cord-296347-fanlvxqs	600	7	US2	US2	NNP
cord-296347-fanlvxqs	600	8	,	,	,
cord-296347-fanlvxqs	600	9	as	as	IN
cord-296347-fanlvxqs	600	10	reduction	reduction	NN
cord-296347-fanlvxqs	600	11	of	of	IN
cord-296347-fanlvxqs	600	12	its	-PRON-	PRP$
cord-296347-fanlvxqs	600	13	levels	level	NNS
cord-296347-fanlvxqs	600	14	by	by	IN
cord-296347-fanlvxqs	600	15	RNA	RNA	NNP
cord-296347-fanlvxqs	600	16	interference	interference	NN
cord-296347-fanlvxqs	600	17	blocks	block	VBZ
cord-296347-fanlvxqs	600	18	HC	HC	NNP
cord-296347-fanlvxqs	600	19	degradation	degradation	NN
cord-296347-fanlvxqs	600	20	.	.	.
cord-296347-fanlvxqs	601	1	The	the	DT
cord-296347-fanlvxqs	601	2	question	question	NN
cord-296347-fanlvxqs	601	3	remains	remain	VBZ
cord-296347-fanlvxqs	601	4	as	as	IN
cord-296347-fanlvxqs	601	5	to	to	IN
cord-296347-fanlvxqs	601	6	the	the	DT
cord-296347-fanlvxqs	601	7	detailed	detailed	JJ
cord-296347-fanlvxqs	601	8	mechanism	mechanism	NN
cord-296347-fanlvxqs	601	9	of	of	IN
cord-296347-fanlvxqs	601	10	its	-PRON-	PRP$
cord-296347-fanlvxqs	601	11	involvement	involvement	NN
cord-296347-fanlvxqs	601	12	.	.	.
cord-296347-fanlvxqs	602	1	An	an	DT
cord-296347-fanlvxqs	602	2	obvious	obvious	JJ
cord-296347-fanlvxqs	602	3	possibility	possibility	NN
cord-296347-fanlvxqs	602	4	is	be	VBZ
cord-296347-fanlvxqs	602	5	involvement	involvement	NN
cord-296347-fanlvxqs	602	6	of	of	IN
cord-296347-fanlvxqs	602	7	the	the	DT
cord-296347-fanlvxqs	602	8	catalytic	catalytic	JJ
cord-296347-fanlvxqs	602	9	activity	activity	NN
cord-296347-fanlvxqs	602	10	of	of	IN
cord-296347-fanlvxqs	602	11	SPP	SPP	NNS
cord-296347-fanlvxqs	602	12	.	.	.
cord-296347-fanlvxqs	603	1	This	this	DT
cord-296347-fanlvxqs	603	2	would	would	MD
cord-296347-fanlvxqs	603	3	imply	imply	VB
cord-296347-fanlvxqs	603	4	a	a	DT
cord-296347-fanlvxqs	603	5	cleavage	cleavage	NN
cord-296347-fanlvxqs	603	6	event	event	NN
cord-296347-fanlvxqs	603	7	during	during	IN
cord-296347-fanlvxqs	603	8	dislocation	dislocation	NN
cord-296347-fanlvxqs	603	9	,	,	,
cord-296347-fanlvxqs	603	10	such	such	JJ
cord-296347-fanlvxqs	603	11	as	as	IN
cord-296347-fanlvxqs	603	12	within	within	IN
cord-296347-fanlvxqs	603	13	the	the	DT
cord-296347-fanlvxqs	603	14	TMD	TMD	NNP
cord-296347-fanlvxqs	603	15	of	of	IN
cord-296347-fanlvxqs	603	16	US2	US2	NNP
cord-296347-fanlvxqs	603	17	or	or	CC
cord-296347-fanlvxqs	603	18	HC	HC	NNP
cord-296347-fanlvxqs	603	19	or	or	CC
cord-296347-fanlvxqs	603	20	another	another	DT
cord-296347-fanlvxqs	603	21	factor	factor	NN
cord-296347-fanlvxqs	603	22	,	,	,
cord-296347-fanlvxqs	603	23	unknown	unknown	JJ
cord-296347-fanlvxqs	603	24	at	at	IN
cord-296347-fanlvxqs	603	25	this	this	DT
cord-296347-fanlvxqs	603	26	point	point	NN
cord-296347-fanlvxqs	603	27	;	;	:
cord-296347-fanlvxqs	603	28	a	a	DT
cord-296347-fanlvxqs	603	29	postcleavage	postcleavage	NN
cord-296347-fanlvxqs	603	30	function	function	NN
cord-296347-fanlvxqs	603	31	of	of	IN
cord-296347-fanlvxqs	603	32	one	one	CD
cord-296347-fanlvxqs	603	33	of	of	IN
cord-296347-fanlvxqs	603	34	these	these	DT
cord-296347-fanlvxqs	603	35	protein	protein	NN
cord-296347-fanlvxqs	603	36	fragments	fragment	NNS
cord-296347-fanlvxqs	603	37	could	could	MD
cord-296347-fanlvxqs	603	38	play	play	VB
cord-296347-fanlvxqs	603	39	a	a	DT
cord-296347-fanlvxqs	603	40	regulatory	regulatory	JJ
cord-296347-fanlvxqs	603	41	role	role	NN
cord-296347-fanlvxqs	603	42	in	in	IN
cord-296347-fanlvxqs	603	43	the	the	DT
cord-296347-fanlvxqs	603	44	process	process	NN
cord-296347-fanlvxqs	603	45	.	.	.
cord-296347-fanlvxqs	604	1	SPPmediated	SPPmediated	NNP
cord-296347-fanlvxqs	604	2	intramembrane	intramembrane	NNP
cord-296347-fanlvxqs	604	3	proteolysis	proteolysis	NN
cord-296347-fanlvxqs	604	4	requires	require	VBZ
cord-296347-fanlvxqs	604	5	,	,	,
cord-296347-fanlvxqs	604	6	among	among	IN
cord-296347-fanlvxqs	604	7	other	other	JJ
cord-296347-fanlvxqs	604	8	things	thing	NNS
cord-296347-fanlvxqs	604	9	,	,	,
cord-296347-fanlvxqs	604	10	a	a	DT
cord-296347-fanlvxqs	604	11	membrane	membrane	NN
cord-296347-fanlvxqs	604	12	protein	protein	NN
cord-296347-fanlvxqs	604	13	substrate	substrate	NN
cord-296347-fanlvxqs	604	14	to	to	TO
cord-296347-fanlvxqs	604	15	have	have	VB
cord-296347-fanlvxqs	604	16	access	access	NN
cord-296347-fanlvxqs	604	17	to	to	IN
cord-296347-fanlvxqs	604	18	its	-PRON-	PRP$
cord-296347-fanlvxqs	604	19	catalytic	catalytic	JJ
cord-296347-fanlvxqs	604	20	core	core	NN
cord-296347-fanlvxqs	604	21	in	in	IN
cord-296347-fanlvxqs	604	22	a	a	DT
cord-296347-fanlvxqs	604	23	type	type	NN
cord-296347-fanlvxqs	604	24	II	II	NNP
cord-296347-fanlvxqs	604	25	orientation	orientation	NN
cord-296347-fanlvxqs	604	26	Martoglio	Martoglio	NNP
cord-296347-fanlvxqs	604	27	and	and	CC
cord-296347-fanlvxqs	604	28	Golde	Golde	NNP
cord-296347-fanlvxqs	604	29	,	,	,
cord-296347-fanlvxqs	604	30	2003	2003	CD
cord-296347-fanlvxqs	604	31	)	)	-RRB-
cord-296347-fanlvxqs	604	32	.	.	.
cord-296347-fanlvxqs	605	1	Both	both	DT
cord-296347-fanlvxqs	605	2	US2	US2	NNP
cord-296347-fanlvxqs	605	3	and	and	CC
cord-296347-fanlvxqs	605	4	HC	HC	NNP
cord-296347-fanlvxqs	605	5	are	be	VBP
cord-296347-fanlvxqs	605	6	type	type	NN
cord-296347-fanlvxqs	605	7	I	-PRON-	PRP
cord-296347-fanlvxqs	605	8	membrane	membrane	NN
cord-296347-fanlvxqs	605	9	glycoproteins	glycoprotein	NNS
cord-296347-fanlvxqs	605	10	,	,	,
cord-296347-fanlvxqs	605	11	so	so	IN
cord-296347-fanlvxqs	605	12	the	the	DT
cord-296347-fanlvxqs	605	13	topology	topology	NN
cord-296347-fanlvxqs	605	14	of	of	IN
cord-296347-fanlvxqs	605	15	their	-PRON-	PRP$
cord-296347-fanlvxqs	605	16	transmembrane	transmembrane	NN
cord-296347-fanlvxqs	605	17	and	and	CC
cord-296347-fanlvxqs	605	18	tail	tail	NN
cord-296347-fanlvxqs	605	19	segments	segment	NNS
cord-296347-fanlvxqs	605	20	is	be	VBZ
cord-296347-fanlvxqs	605	21	opposite	opposite	JJ
cord-296347-fanlvxqs	605	22	to	to	IN
cord-296347-fanlvxqs	605	23	that	that	DT
cord-296347-fanlvxqs	605	24	of	of	IN
cord-296347-fanlvxqs	605	25	predicted	predict	VBN
cord-296347-fanlvxqs	605	26	SPP	spp	NN
cord-296347-fanlvxqs	605	27	substrates	substrate	NNS
cord-296347-fanlvxqs	605	28	.	.	.
cord-296347-fanlvxqs	606	1	SPP	spp	NN
cord-296347-fanlvxqs	606	2	-	-	HYPH
cord-296347-fanlvxqs	606	3	mediated	mediate	VBN
cord-296347-fanlvxqs	606	4	intramembrane	intramembrane	NN
cord-296347-fanlvxqs	606	5	cleavage	cleavage	NN
cord-296347-fanlvxqs	606	6	within	within	IN
cord-296347-fanlvxqs	606	7	the	the	DT
cord-296347-fanlvxqs	606	8	HC	HC	NNP
cord-296347-fanlvxqs	606	9	TMD	TMD	NNP
cord-296347-fanlvxqs	606	10	is	be	VBZ
cord-296347-fanlvxqs	606	11	inconsistent	inconsistent	JJ
cord-296347-fanlvxqs	606	12	with	with	IN
cord-296347-fanlvxqs	606	13	the	the	DT
cord-296347-fanlvxqs	606	14	observed	observed	JJ
cord-296347-fanlvxqs	606	15	recovery	recovery	NN
cord-296347-fanlvxqs	606	16	of	of	IN
cord-296347-fanlvxqs	606	17	full	full	JJ
cord-296347-fanlvxqs	606	18	length	length	NN
cord-296347-fanlvxqs	606	19	HC	HC	NNP
cord-296347-fanlvxqs	606	20	in	in	IN
cord-296347-fanlvxqs	606	21	the	the	DT
cord-296347-fanlvxqs	606	22	dislocation	dislocation	NN
cord-296347-fanlvxqs	606	23	reaction	reaction	NN
cord-296347-fanlvxqs	606	24	(	(	-LRB-
cord-296347-fanlvxqs	606	25	Blom	Blom	NNP
cord-296347-fanlvxqs	606	26	et	et	FW
cord-296347-fanlvxqs	606	27	al	al	NNP
cord-296347-fanlvxqs	606	28	.	.	.
cord-296347-fanlvxqs	607	1	,	,	,
cord-296347-fanlvxqs	607	2	2004	2004	CD
cord-296347-fanlvxqs	607	3	;	;	:
cord-296347-fanlvxqs	607	4	Misaghi	Misaghi	NNP
cord-296347-fanlvxqs	607	5	et	et	NNP
cord-296347-fanlvxqs	607	6	al	al	NNP
cord-296347-fanlvxqs	607	7	.	.	.
cord-296347-fanlvxqs	608	1	,	,	,
cord-296347-fanlvxqs	608	2	2004a	2004a	CD
cord-296347-fanlvxqs	608	3	;	;	:
cord-296347-fanlvxqs	608	4	Wiertz	Wiertz	NNP
cord-296347-fanlvxqs	608	5	et	et	NNP
cord-296347-fanlvxqs	608	6	al	al	NNP
cord-296347-fanlvxqs	608	7	.	.	NNP
cord-296347-fanlvxqs	608	8	,	,	,
cord-296347-fanlvxqs	608	9	1996a	1996a	CD
cord-296347-fanlvxqs	608	10	,	,	,
cord-296347-fanlvxqs	608	11	b	b	LS
cord-296347-fanlvxqs	608	12	)	)	-RRB-
cord-296347-fanlvxqs	608	13	.	.	.
cord-296347-fanlvxqs	609	1	For	for	IN
cord-296347-fanlvxqs	609	2	US2	US2	NNP
cord-296347-fanlvxqs	609	3	,	,	,
cord-296347-fanlvxqs	609	4	while	while	IN
cord-296347-fanlvxqs	609	5	a	a	DT
cord-296347-fanlvxqs	609	6	suggested	suggest	VBN
cord-296347-fanlvxqs	609	7	protein	protein	NN
cord-296347-fanlvxqs	609	8	-	-	HYPH
cord-296347-fanlvxqs	609	9	protein	protein	NN
cord-296347-fanlvxqs	609	10	interaction	interaction	NN
cord-296347-fanlvxqs	609	11	domain	domain	NN
cord-296347-fanlvxqs	609	12	in	in	IN
cord-296347-fanlvxqs	609	13	the	the	DT
cord-296347-fanlvxqs	609	14	US2	US2	NNP
cord-296347-fanlvxqs	609	15	tail	tail	NN
cord-296347-fanlvxqs	610	1	(	(	-LRB-
cord-296347-fanlvxqs	610	2	Oresic	Oresic	NNP
cord-296347-fanlvxqs	610	3	et	et	NNP
cord-296347-fanlvxqs	610	4	al	al	NNP
cord-296347-fanlvxqs	610	5	.	.	NNP
cord-296347-fanlvxqs	610	6	,	,	,
cord-296347-fanlvxqs	610	7	2006	2006	CD
cord-296347-fanlvxqs	610	8	)	)	-RRB-
cord-296347-fanlvxqs	610	9	may	may	MD
cord-296347-fanlvxqs	610	10	mediate	mediate	VB
cord-296347-fanlvxqs	610	11	binding	bind	VBG
cord-296347-fanlvxqs	610	12	to	to	IN
cord-296347-fanlvxqs	610	13	SPP	SPP	NNP
cord-296347-fanlvxqs	610	14	,	,	,
cord-296347-fanlvxqs	610	15	intramembrane	intramembrane	NNP
cord-296347-fanlvxqs	610	16	cleavage	cleavage	NN
cord-296347-fanlvxqs	610	17	of	of	IN
cord-296347-fanlvxqs	610	18	the	the	DT
cord-296347-fanlvxqs	610	19	US2	US2	NNP
cord-296347-fanlvxqs	610	20	TMD	TMD	NNP
cord-296347-fanlvxqs	610	21	by	by	IN
cord-296347-fanlvxqs	610	22	SPP	SPP	NNS
cord-296347-fanlvxqs	610	23	in	in	IN
cord-296347-fanlvxqs	610	24	this	this	DT
cord-296347-fanlvxqs	610	25	inverted	inverted	JJ
cord-296347-fanlvxqs	610	26	orientation	orientation	NN
cord-296347-fanlvxqs	610	27	would	would	MD
cord-296347-fanlvxqs	610	28	presumably	presumably	RB
cord-296347-fanlvxqs	610	29	not	not	RB
cord-296347-fanlvxqs	610	30	occur	occur	VB
cord-296347-fanlvxqs	610	31	,	,	,
cord-296347-fanlvxqs	610	32	as	as	IN
cord-296347-fanlvxqs	610	33	seen	see	VBN
cord-296347-fanlvxqs	610	34	for	for	IN
cord-296347-fanlvxqs	610	35	other	other	JJ
cord-296347-fanlvxqs	610	36	proteases	protease	NNS
cord-296347-fanlvxqs	610	37	(	(	-LRB-
cord-296347-fanlvxqs	610	38	Roques	Roques	NNP
cord-296347-fanlvxqs	610	39	et	et	NNP
cord-296347-fanlvxqs	610	40	al	al	NNP
cord-296347-fanlvxqs	610	41	.	.	NNP
cord-296347-fanlvxqs	610	42	,	,	,
cord-296347-fanlvxqs	610	43	1983	1983	CD
cord-296347-fanlvxqs	610	44	;	;	.
cord-296347-fanlvxqs	611	1	Tarasova	Tarasova	NNP
cord-296347-fanlvxqs	611	2	et	et	NNP
cord-296347-fanlvxqs	611	3	al	al	NNP
cord-296347-fanlvxqs	611	4	.	.	NNP
cord-296347-fanlvxqs	611	5	,	,	,
cord-296347-fanlvxqs	611	6	2005	2005	CD
cord-296347-fanlvxqs	611	7	)	)	-RRB-
cord-296347-fanlvxqs	611	8	.	.	.
cord-296347-fanlvxqs	612	1	However	however	RB
cord-296347-fanlvxqs	612	2	,	,	,
cord-296347-fanlvxqs	612	3	the	the	DT
cord-296347-fanlvxqs	612	4	proposed	propose	VBN
cord-296347-fanlvxqs	612	5	bent	bent	JJ
cord-296347-fanlvxqs	612	6	-	-	HYPH
cord-296347-fanlvxqs	612	7	helix	helix	NN
cord-296347-fanlvxqs	612	8	conformation	conformation	NN
cord-296347-fanlvxqs	612	9	on	on	IN
cord-296347-fanlvxqs	612	10	the	the	DT
cord-296347-fanlvxqs	612	11	US2	US2	NNP
cord-296347-fanlvxqs	612	12	tail	tail	NN
cord-296347-fanlvxqs	613	1	(	(	-LRB-
cord-296347-fanlvxqs	613	2	Oresic	Oresic	NNP
cord-296347-fanlvxqs	613	3	et	et	NNP
cord-296347-fanlvxqs	613	4	al	al	NNP
cord-296347-fanlvxqs	613	5	.	.	NNP
cord-296347-fanlvxqs	613	6	,	,	,
cord-296347-fanlvxqs	613	7	2006	2006	CD
cord-296347-fanlvxqs	613	8	)	)	-RRB-
cord-296347-fanlvxqs	613	9	might	may	MD
cord-296347-fanlvxqs	613	10	allow	allow	VB
cord-296347-fanlvxqs	613	11	US2	US2	NNP
cord-296347-fanlvxqs	613	12	to	to	TO
cord-296347-fanlvxqs	613	13	conform	conform	VB
cord-296347-fanlvxqs	613	14	to	to	IN
cord-296347-fanlvxqs	613	15	the	the	DT
cord-296347-fanlvxqs	613	16	requirements	requirement	NNS
cord-296347-fanlvxqs	613	17	for	for	IN
cord-296347-fanlvxqs	613	18	SPP	spp	NN
cord-296347-fanlvxqs	613	19	cleavage	cleavage	NN
cord-296347-fanlvxqs	613	20	.	.	.
cord-296347-fanlvxqs	614	1	Whether	whether	IN
cord-296347-fanlvxqs	614	2	SPP	spp	NN
cord-296347-fanlvxqs	614	3	-	-	HYPH
cord-296347-fanlvxqs	614	4	mediated	mediate	VBN
cord-296347-fanlvxqs	614	5	US2	US2	NNP
cord-296347-fanlvxqs	614	6	cleavage	cleavage	NN
cord-296347-fanlvxqs	614	7	takes	take	VBZ
cord-296347-fanlvxqs	614	8	place	place	NN
cord-296347-fanlvxqs	614	9	is	be	VBZ
cord-296347-fanlvxqs	614	10	unknown	unknown	JJ
cord-296347-fanlvxqs	614	11	at	at	IN
cord-296347-fanlvxqs	614	12	this	this	DT
cord-296347-fanlvxqs	614	13	point	point	NN
cord-296347-fanlvxqs	614	14	.	.	.
cord-296347-fanlvxqs	615	1	One	one	PRP
cord-296347-fanlvxqs	615	2	can	can	MD
cord-296347-fanlvxqs	615	3	speculate	speculate	VB
cord-296347-fanlvxqs	615	4	that	that	IN
cord-296347-fanlvxqs	615	5	this	this	DT
cord-296347-fanlvxqs	615	6	putative	putative	JJ
cord-296347-fanlvxqs	615	7	processing	processing	NN
cord-296347-fanlvxqs	615	8	of	of	IN
cord-296347-fanlvxqs	615	9	US2	US2	NNP
cord-296347-fanlvxqs	615	10	by	by	IN
cord-296347-fanlvxqs	615	11	SPP	SPP	NNP
cord-296347-fanlvxqs	615	12	,	,	,
cord-296347-fanlvxqs	615	13	as	as	IN
cord-296347-fanlvxqs	615	14	for	for	IN
cord-296347-fanlvxqs	615	15	the	the	DT
cord-296347-fanlvxqs	615	16	HCV	HCV	NNP
cord-296347-fanlvxqs	615	17	core	core	NN
cord-296347-fanlvxqs	615	18	protein	protein	NN
cord-296347-fanlvxqs	615	19	(	(	-LRB-
cord-296347-fanlvxqs	615	20	McLauchlan	McLauchlan	NNP
cord-296347-fanlvxqs	615	21	et	et	NNP
cord-296347-fanlvxqs	615	22	al	al	NNP
cord-296347-fanlvxqs	615	23	.	.	NNP
cord-296347-fanlvxqs	615	24	,	,	,
cord-296347-fanlvxqs	615	25	2002	2002	CD
cord-296347-fanlvxqs	615	26	)	)	-RRB-
cord-296347-fanlvxqs	615	27	,	,	,
cord-296347-fanlvxqs	615	28	could	could	MD
cord-296347-fanlvxqs	615	29	be	be	VB
cord-296347-fanlvxqs	615	30	necessary	necessary	JJ
cord-296347-fanlvxqs	615	31	for	for	IN
cord-296347-fanlvxqs	615	32	'	'	``
cord-296347-fanlvxqs	615	33	'	'	``
cord-296347-fanlvxqs	615	34	maturation	maturation	NN
cord-296347-fanlvxqs	615	35	'	'	''
cord-296347-fanlvxqs	615	36	'	'	''
cord-296347-fanlvxqs	615	37	of	of	IN
cord-296347-fanlvxqs	615	38	US2	US2	NNP
cord-296347-fanlvxqs	615	39	into	into	IN
cord-296347-fanlvxqs	615	40	a	a	DT
cord-296347-fanlvxqs	615	41	dislocation	dislocation	NN
cord-296347-fanlvxqs	615	42	-	-	HYPH
cord-296347-fanlvxqs	615	43	active	active	JJ
cord-296347-fanlvxqs	615	44	form	form	NN
cord-296347-fanlvxqs	615	45	.	.	.
cord-296347-fanlvxqs	616	1	Binding	bind	VBG
cord-296347-fanlvxqs	616	2	of	of	IN
cord-296347-fanlvxqs	616	3	US2	US2	NNP
cord-296347-fanlvxqs	616	4	to	to	IN
cord-296347-fanlvxqs	616	5	SPP	SPP	NNP
cord-296347-fanlvxqs	616	6	could	could	MD
cord-296347-fanlvxqs	616	7	still	still	RB
cord-296347-fanlvxqs	616	8	modulate	modulate	VB
cord-296347-fanlvxqs	616	9	SPP	spp	NN
cord-296347-fanlvxqs	616	10	enzymatic	enzymatic	JJ
cord-296347-fanlvxqs	616	11	activity	activity	NN
cord-296347-fanlvxqs	616	12	and	and	CC
cord-296347-fanlvxqs	616	13	thus	thus	RB
cord-296347-fanlvxqs	616	14	affect	affect	VBP
cord-296347-fanlvxqs	616	15	dislocation	dislocation	NN
cord-296347-fanlvxqs	616	16	.	.	.
cord-296347-fanlvxqs	617	1	The	the	DT
cord-296347-fanlvxqs	617	2	possibility	possibility	NN
cord-296347-fanlvxqs	617	3	remains	remain	VBZ
cord-296347-fanlvxqs	617	4	that	that	IN
cord-296347-fanlvxqs	617	5	SPP	SPP	NNP
cord-296347-fanlvxqs	617	6	mediates	mediate	VBZ
cord-296347-fanlvxqs	617	7	cleavage	cleavage	NN
cord-296347-fanlvxqs	617	8	in	in	IN
cord-296347-fanlvxqs	617	9	trans	trans	NNP
cord-296347-fanlvxqs	617	10	of	of	IN
cord-296347-fanlvxqs	617	11	an	an	DT
cord-296347-fanlvxqs	617	12	unidentified	unidentified	JJ
cord-296347-fanlvxqs	617	13	factor	factor	NN
cord-296347-fanlvxqs	617	14	whose	whose	WP$
cord-296347-fanlvxqs	617	15	function	function	NN
cord-296347-fanlvxqs	617	16	is	be	VBZ
cord-296347-fanlvxqs	617	17	important	important	JJ
cord-296347-fanlvxqs	617	18	.	.	.
cord-296347-fanlvxqs	618	1	Experiments	experiment	NNS
cord-296347-fanlvxqs	618	2	with	with	IN
cord-296347-fanlvxqs	618	3	SPP	spp	NN
cord-296347-fanlvxqs	618	4	inhibitors	inhibitor	NNS
cord-296347-fanlvxqs	618	5	and	and	CC
cord-296347-fanlvxqs	618	6	catalytic	catalytic	JJ
cord-296347-fanlvxqs	618	7	mutants	mutant	NNS
cord-296347-fanlvxqs	618	8	of	of	IN
cord-296347-fanlvxqs	618	9	SPP	SPP	NNS
cord-296347-fanlvxqs	618	10	should	should	MD
cord-296347-fanlvxqs	618	11	allow	allow	VB
cord-296347-fanlvxqs	618	12	an	an	DT
cord-296347-fanlvxqs	618	13	assessment	assessment	NN
cord-296347-fanlvxqs	618	14	of	of	IN
cord-296347-fanlvxqs	618	15	the	the	DT
cord-296347-fanlvxqs	618	16	contribution	contribution	NN
cord-296347-fanlvxqs	618	17	of	of	IN
cord-296347-fanlvxqs	618	18	the	the	DT
cord-296347-fanlvxqs	618	19	proteolytic	proteolytic	JJ
cord-296347-fanlvxqs	618	20	properties	property	NNS
cord-296347-fanlvxqs	618	21	of	of	IN
cord-296347-fanlvxqs	618	22	SPP	SPP	NNS
cord-296347-fanlvxqs	618	23	to	to	IN
cord-296347-fanlvxqs	618	24	dislocation	dislocation	NN
cord-296347-fanlvxqs	618	25	.	.	.
cord-296347-fanlvxqs	619	1	The	the	DT
cord-296347-fanlvxqs	619	2	involvement	involvement	NN
cord-296347-fanlvxqs	619	3	of	of	IN
cord-296347-fanlvxqs	619	4	SPP	spp	NN
cord-296347-fanlvxqs	619	5	need	nee	MD
cord-296347-fanlvxqs	619	6	not	not	RB
cord-296347-fanlvxqs	619	7	be	be	VB
cord-296347-fanlvxqs	619	8	related	relate	VBN
cord-296347-fanlvxqs	619	9	to	to	IN
cord-296347-fanlvxqs	619	10	its	-PRON-	PRP$
cord-296347-fanlvxqs	619	11	catalytic	catalytic	JJ
cord-296347-fanlvxqs	619	12	activity	activity	NN
cord-296347-fanlvxqs	619	13	.	.	.
cord-296347-fanlvxqs	620	1	Substrate	substrate	NN
cord-296347-fanlvxqs	620	2	recruitment	recruitment	NN
cord-296347-fanlvxqs	620	3	and	and	CC
cord-296347-fanlvxqs	620	4	subsequent	subsequent	JJ
cord-296347-fanlvxqs	620	5	cleavage	cleavage	NN
cord-296347-fanlvxqs	620	6	by	by	IN
cord-296347-fanlvxqs	620	7	SPP	SPP	NNP
cord-296347-fanlvxqs	620	8	may	may	MD
cord-296347-fanlvxqs	620	9	be	be	VB
cord-296347-fanlvxqs	620	10	separable	separable	JJ
cord-296347-fanlvxqs	620	11	events	event	NNS
cord-296347-fanlvxqs	620	12	,	,	,
cord-296347-fanlvxqs	620	13	as	as	IN
cord-296347-fanlvxqs	620	14	shown	show	VBN
cord-296347-fanlvxqs	620	15	for	for	IN
cord-296347-fanlvxqs	620	16	the	the	DT
cord-296347-fanlvxqs	620	17	related	related	JJ
cord-296347-fanlvxqs	620	18	PS	PS	NNP
cord-296347-fanlvxqs	620	19	(	(	-LRB-
cord-296347-fanlvxqs	620	20	Kornilova	Kornilova	NNP
cord-296347-fanlvxqs	620	21	et	et	FW
cord-296347-fanlvxqs	620	22	al	al	NNP
cord-296347-fanlvxqs	620	23	.	.	NNP
cord-296347-fanlvxqs	620	24	,	,	,
cord-296347-fanlvxqs	620	25	2003	2003	CD
cord-296347-fanlvxqs	620	26	;	;	:
cord-296347-fanlvxqs	620	27	Lemberg	Lemberg	NNP
cord-296347-fanlvxqs	620	28	and	and	CC
cord-296347-fanlvxqs	620	29	Martoglio	Martoglio	NNP
cord-296347-fanlvxqs	620	30	,	,	,
cord-296347-fanlvxqs	620	31	2004	2004	CD
cord-296347-fanlvxqs	620	32	)	)	-RRB-
cord-296347-fanlvxqs	620	33	.	.	.
cord-296347-fanlvxqs	621	1	Some	some	DT
cord-296347-fanlvxqs	621	2	intracellular	intracellular	JJ
cord-296347-fanlvxqs	621	3	cleavage	cleavage	NN
cord-296347-fanlvxqs	621	4	products	product	NNS
cord-296347-fanlvxqs	621	5	of	of	IN
cord-296347-fanlvxqs	621	6	g	g	NNP
cord-296347-fanlvxqs	621	7	-	-	HYPH
cord-296347-fanlvxqs	621	8	secretase	secretase	NNP
cord-296347-fanlvxqs	621	9	are	be	VBP
cord-296347-fanlvxqs	621	10	proposed	propose	VBN
cord-296347-fanlvxqs	621	11	to	to	TO
cord-296347-fanlvxqs	621	12	be	be	VB
cord-296347-fanlvxqs	621	13	intermediates	intermediate	NNS
cord-296347-fanlvxqs	621	14	that	that	WDT
cord-296347-fanlvxqs	621	15	are	be	VBP
cord-296347-fanlvxqs	621	16	destined	destine	VBN
cord-296347-fanlvxqs	621	17	for	for	IN
cord-296347-fanlvxqs	621	18	degradation	degradation	NN
cord-296347-fanlvxqs	621	19	(	(	-LRB-
cord-296347-fanlvxqs	621	20	Kopan	Kopan	NNP
cord-296347-fanlvxqs	621	21	and	and	CC
cord-296347-fanlvxqs	621	22	Ilagan	Ilagan	NNP
cord-296347-fanlvxqs	621	23	,	,	,
cord-296347-fanlvxqs	621	24	2004	2004	CD
cord-296347-fanlvxqs	621	25	;	;	:
cord-296347-fanlvxqs	621	26	Parent	Parent	NNP
cord-296347-fanlvxqs	621	27	et	et	NNP
cord-296347-fanlvxqs	621	28	al	al	NNP
cord-296347-fanlvxqs	621	29	.	.	NNP
cord-296347-fanlvxqs	621	30	,	,	,
cord-296347-fanlvxqs	621	31	2005	2005	CD
cord-296347-fanlvxqs	621	32	)	)	-RRB-
cord-296347-fanlvxqs	621	33	.	.	.
cord-296347-fanlvxqs	622	1	g	g	NNP
cord-296347-fanlvxqs	622	2	-	-	HYPH
cord-296347-fanlvxqs	622	3	secretase	secretase	NNP
cord-296347-fanlvxqs	622	4	-	-	HYPH
cord-296347-fanlvxqs	622	5	mediated	mediate	VBN
cord-296347-fanlvxqs	622	6	cleavage	cleavage	NN
cord-296347-fanlvxqs	622	7	of	of	IN
cord-296347-fanlvxqs	622	8	a	a	DT
cord-296347-fanlvxqs	622	9	large	large	JJ
cord-296347-fanlvxqs	622	10	number	number	NN
cord-296347-fanlvxqs	622	11	of	of	IN
cord-296347-fanlvxqs	622	12	type	type	NN
cord-296347-fanlvxqs	622	13	I	-PRON-	PRP
cord-296347-fanlvxqs	622	14	transmembrane	transmembrane	NN
cord-296347-fanlvxqs	622	15	proteins	protein	NNS
cord-296347-fanlvxqs	622	16	releases	release	VBZ
cord-296347-fanlvxqs	622	17	their	-PRON-	PRP$
cord-296347-fanlvxqs	622	18	C	c	NN
cord-296347-fanlvxqs	622	19	-	-	HYPH
cord-296347-fanlvxqs	622	20	terminal	terminal	NN
cord-296347-fanlvxqs	622	21	fragments	fragment	NNS
cord-296347-fanlvxqs	622	22	(	(	-LRB-
cord-296347-fanlvxqs	622	23	CTFs	ctf	NNS
cord-296347-fanlvxqs	622	24	)	)	-RRB-
cord-296347-fanlvxqs	622	25	.	.	.
cord-296347-fanlvxqs	623	1	PS1	PS1	NNP
cord-296347-fanlvxqs	623	2	deficiency	deficiency	NN
cord-296347-fanlvxqs	623	3	causes	cause	VBZ
cord-296347-fanlvxqs	623	4	delayed	delay	VBN
cord-296347-fanlvxqs	623	5	turnover	turnover	NN
cord-296347-fanlvxqs	623	6	and	and	CC
cord-296347-fanlvxqs	623	7	subsequent	subsequent	JJ
cord-296347-fanlvxqs	623	8	accumulation	accumulation	NN
cord-296347-fanlvxqs	623	9	of	of	IN
cord-296347-fanlvxqs	623	10	some	some	DT
cord-296347-fanlvxqs	623	11	g	g	NN
cord-296347-fanlvxqs	623	12	-	-	HYPH
cord-296347-fanlvxqs	623	13	secretase	secretase	NN
cord-296347-fanlvxqs	623	14	substrates	substrate	NNS
cord-296347-fanlvxqs	623	15	as	as	IN
cord-296347-fanlvxqs	623	16	full	full	JJ
cord-296347-fanlvxqs	623	17	-	-	HYPH
cord-296347-fanlvxqs	623	18	length	length	NN
cord-296347-fanlvxqs	623	19	proteins	protein	NNS
cord-296347-fanlvxqs	623	20	(	(	-LRB-
cord-296347-fanlvxqs	623	21	Esselens	Esselens	NNPS
cord-296347-fanlvxqs	623	22	et	et	NNP
cord-296347-fanlvxqs	623	23	al	al	NNP
cord-296347-fanlvxqs	623	24	.	.	NNP
cord-296347-fanlvxqs	623	25	,	,	,
cord-296347-fanlvxqs	623	26	2004	2004	CD
cord-296347-fanlvxqs	623	27	;	;	:
cord-296347-fanlvxqs	623	28	Wang	Wang	NNP
cord-296347-fanlvxqs	623	29	et	et	NNP
cord-296347-fanlvxqs	623	30	al	al	NNP
cord-296347-fanlvxqs	623	31	.	.	NNP
cord-296347-fanlvxqs	623	32	,	,	,
cord-296347-fanlvxqs	623	33	2006c	2006c	CD
cord-296347-fanlvxqs	623	34	;	;	:
cord-296347-fanlvxqs	624	1	Wilson	Wilson	NNP
cord-296347-fanlvxqs	624	2	et	et	NNP
cord-296347-fanlvxqs	624	3	al	al	NNP
cord-296347-fanlvxqs	624	4	.	.	NNP
cord-296347-fanlvxqs	624	5	,	,	,
cord-296347-fanlvxqs	624	6	2004c	2004c	CD
cord-296347-fanlvxqs	624	7	)	)	-RRB-
cord-296347-fanlvxqs	624	8	,	,	,
cord-296347-fanlvxqs	624	9	suggesting	suggest	VBG
cord-296347-fanlvxqs	624	10	cleavage	cleavage	NN
cord-296347-fanlvxqs	624	11	of	of	IN
cord-296347-fanlvxqs	624	12	the	the	DT
cord-296347-fanlvxqs	624	13	CTFs	ctf	NNS
cord-296347-fanlvxqs	624	14	as	as	IN
cord-296347-fanlvxqs	624	15	a	a	DT
cord-296347-fanlvxqs	624	16	prelude	prelude	NN
cord-296347-fanlvxqs	624	17	to	to	IN
cord-296347-fanlvxqs	624	18	degradation	degradation	NN
cord-296347-fanlvxqs	624	19	.	.	.
cord-296347-fanlvxqs	625	1	Treatment	treatment	NN
cord-296347-fanlvxqs	625	2	with	with	IN
cord-296347-fanlvxqs	625	3	g	g	NNP
cord-296347-fanlvxqs	625	4	-	-	HYPH
cord-296347-fanlvxqs	625	5	secretase	secretase	NNP
cord-296347-fanlvxqs	625	6	inhibitors	inhibitor	NNS
cord-296347-fanlvxqs	625	7	,	,	,
cord-296347-fanlvxqs	625	8	however	however	RB
cord-296347-fanlvxqs	625	9	,	,	,
cord-296347-fanlvxqs	625	10	does	do	VBZ
cord-296347-fanlvxqs	625	11	not	not	RB
cord-296347-fanlvxqs	625	12	phenocopy	phenocopy	VB
cord-296347-fanlvxqs	625	13	PS	PS	NNP
cord-296347-fanlvxqs	625	14	deficiency	deficiency	NN
cord-296347-fanlvxqs	626	1	(	(	-LRB-
cord-296347-fanlvxqs	626	2	Wang	Wang	NNP
cord-296347-fanlvxqs	626	3	et	et	NNP
cord-296347-fanlvxqs	626	4	al	al	NNP
cord-296347-fanlvxqs	626	5	.	.	.
cord-296347-fanlvxqs	627	1	,	,	,
cord-296347-fanlvxqs	627	2	2006	2006	CD
cord-296347-fanlvxqs	627	3	c	c	NNP
cord-296347-fanlvxqs	627	4	)	)	-RRB-
cord-296347-fanlvxqs	627	5	,	,	,
cord-296347-fanlvxqs	627	6	suggestin	suggestin	VBZ
cord-296347-fanlvxqs	627	7	g	g	NNP
cord-296347-fanlvxqs	627	8	tha	tha	NNP
cord-296347-fanlvxqs	627	9	t	t	NN
cord-296347-fanlvxqs	628	1	this	this	DT
cord-296347-fanlvxqs	628	2	effec	effec	NNP
cord-296347-fanlvxqs	628	3	t	t	NN
cord-296347-fanlvxqs	628	4	is	be	VBZ
cord-296347-fanlvxqs	628	5	in	in	IN
cord-296347-fanlvxqs	628	6	dependen	dependen	NNP
cord-296347-fanlvxqs	628	7	t	t	NNP
cord-296347-fanlvxqs	628	8	of	of	IN
cord-296347-fanlvxqs	628	9	gsecre	gsecre	NNP
cord-296347-fanlvxqs	628	10	tase	tase	NNP
cord-296347-fanlvxqs	628	11	activ	activ	NNP
cord-296347-fanlvxqs	628	12	ity	ity	NNP
cord-296347-fanlvxqs	628	13	.	.	.
cord-296347-fanlvxqs	629	1	Therefore	therefore	RB
cord-296347-fanlvxqs	629	2	,	,	,
cord-296347-fanlvxqs	629	3	SPP	SPP	NNP
cord-296347-fanlvxqs	629	4	may	may	MD
cord-296347-fanlvxqs	629	5	be	be	VB
cord-296347-fanlvxqs	629	6	crucial	crucial	JJ
cord-296347-fanlvxqs	629	7	for	for	IN
cord-296347-fanlvxqs	629	8	HC	HC	NNP
cord-296347-fanlvxqs	629	9	dislocation	dislocation	NN
cord-296347-fanlvxqs	629	10	irrespectively	irrespectively	RB
cord-296347-fanlvxqs	629	11	of	of	IN
cord-296347-fanlvxqs	629	12	its	-PRON-	PRP$
cord-296347-fanlvxqs	629	13	catalytic	catalytic	JJ
cord-296347-fanlvxqs	629	14	properties	property	NNS
cord-296347-fanlvxqs	629	15	.	.	.
cord-296347-fanlvxqs	630	1	Binding	bind	VBG
cord-296347-fanlvxqs	630	2	of	of	IN
cord-296347-fanlvxqs	630	3	US2	US2	NNP
cord-296347-fanlvxqs	630	4	to	to	IN
cord-296347-fanlvxqs	630	5	SPP	SPP	NNP
cord-296347-fanlvxqs	630	6	could	could	MD
cord-296347-fanlvxqs	630	7	presumably	presumably	RB
cord-296347-fanlvxqs	630	8	modify	modify	VB
cord-296347-fanlvxqs	630	9	the	the	DT
cord-296347-fanlvxqs	630	10	SPP	SPP	NNP
cord-296347-fanlvxqs	630	11	structure	structure	NN
cord-296347-fanlvxqs	630	12	in	in	IN
cord-296347-fanlvxqs	630	13	a	a	DT
cord-296347-fanlvxqs	630	14	way	way	NN
cord-296347-fanlvxqs	630	15	that	that	WDT
cord-296347-fanlvxqs	630	16	affects	affect	VBZ
cord-296347-fanlvxqs	630	17	dislocation	dislocation	NN
cord-296347-fanlvxqs	630	18	.	.	.
cord-296347-fanlvxqs	631	1	Alternatively	alternatively	RB
cord-296347-fanlvxqs	631	2	,	,	,
cord-296347-fanlvxqs	631	3	recruitment	recruitment	NN
cord-296347-fanlvxqs	631	4	of	of	IN
cord-296347-fanlvxqs	631	5	SPP	SPP	NNP
cord-296347-fanlvxqs	631	6	by	by	IN
cord-296347-fanlvxqs	631	7	US2	US2	NNP
cord-296347-fanlvxqs	631	8	could	could	MD
cord-296347-fanlvxqs	631	9	perhaps	perhaps	RB
cord-296347-fanlvxqs	631	10	nucleate	nucleate	VB
cord-296347-fanlvxqs	631	11	assembly	assembly	NN
cord-296347-fanlvxqs	631	12	of	of	IN
cord-296347-fanlvxqs	631	13	a	a	DT
cord-296347-fanlvxqs	631	14	dislocation	dislocation	NN
cord-296347-fanlvxqs	631	15	complex	complex	NN
cord-296347-fanlvxqs	631	16	,	,	,
cord-296347-fanlvxqs	631	17	much	much	RB
cord-296347-fanlvxqs	631	18	like	like	IN
cord-296347-fanlvxqs	631	19	US11	US11	NNP
cord-296347-fanlvxqs	631	20	and	and	CC
cord-296347-fanlvxqs	631	21	the	the	DT
cord-296347-fanlvxqs	631	22	Derlins	Derlins	NNP
cord-296347-fanlvxqs	631	23	(	(	-LRB-
cord-296347-fanlvxqs	631	24	Lilley	Lilley	NNP
cord-296347-fanlvxqs	631	25	and	and	CC
cord-296347-fanlvxqs	631	26	Ploegh	Ploegh	NNP
cord-296347-fanlvxqs	631	27	,	,	,
cord-296347-fanlvxqs	631	28	2005a	2005a	CD
cord-296347-fanlvxqs	631	29	)	)	-RRB-
cord-296347-fanlvxqs	631	30	.	.	.
cord-296347-fanlvxqs	632	1	SPP	SPP	NNP
cord-296347-fanlvxqs	632	2	may	may	MD
cord-296347-fanlvxqs	632	3	be	be	VB
cord-296347-fanlvxqs	632	4	a	a	DT
cord-296347-fanlvxqs	632	5	component	component	NN
cord-296347-fanlvxqs	632	6	of	of	IN
cord-296347-fanlvxqs	632	7	an	an	DT
cord-296347-fanlvxqs	632	8	ERAD	ERAD	NNP
cord-296347-fanlvxqs	632	9	pathway	pathway	NN
cord-296347-fanlvxqs	632	10	for	for	IN
cord-296347-fanlvxqs	632	11	a	a	DT
cord-296347-fanlvxqs	632	12	subset	subset	NN
cord-296347-fanlvxqs	632	13	of	of	IN
cord-296347-fanlvxqs	632	14	ER	ER	NNP
cord-296347-fanlvxqs	632	15	degradation	degradation	NN
cord-296347-fanlvxqs	632	16	substrates	substrate	NNS
cord-296347-fanlvxqs	632	17	that	that	WDT
cord-296347-fanlvxqs	632	18	includes	include	VBZ
cord-296347-fanlvxqs	632	19	misfolded	misfolde	VBN
cord-296347-fanlvxqs	632	20	transmembrane	transmembrane	NN
cord-296347-fanlvxqs	632	21	proteins	protein	NNS
cord-296347-fanlvxqs	632	22	,	,	,
cord-296347-fanlvxqs	632	23	such	such	JJ
cord-296347-fanlvxqs	632	24	as	as	IN
cord-296347-fanlvxqs	632	25	truncated	truncated	JJ
cord-296347-fanlvxqs	632	26	opsin	opsin	NN
cord-296347-fanlvxqs	632	27	(	(	-LRB-
cord-296347-fanlvxqs	632	28	Crawshaw	Crawshaw	NNP
cord-296347-fanlvxqs	632	29	et	et	NNP
cord-296347-fanlvxqs	632	30	al	al	NNP
cord-296347-fanlvxqs	632	31	.	.	NNP
cord-296347-fanlvxqs	632	32	,	,	,
cord-296347-fanlvxqs	632	33	2004	2004	CD
cord-296347-fanlvxqs	632	34	)	)	-RRB-
cord-296347-fanlvxqs	632	35	,	,	,
cord-296347-fanlvxqs	632	36	and	and	CC
cord-296347-fanlvxqs	632	37	tha	tha	NNP
cord-296347-fanlvxqs	632	38	t	t	NNP
cord-296347-fanlvxqs	632	39	is	be	VBZ
cord-296347-fanlvxqs	632	40	recru	recru	RB
cord-296347-fanlvxqs	632	41	ited	ite	VBN
cord-296347-fanlvxqs	632	42	by	by	IN
cord-296347-fanlvxqs	632	43	US2	US2	NNP
cord-296347-fanlvxqs	632	44	to	to	TO
cord-296347-fanlvxqs	632	45	dislocat	dislocat	NNP
cord-296347-fanlvxqs	632	46	e	e	DT
cord-296347-fanlvxqs	632	47	HC	HC	NNP
cord-296347-fanlvxqs	632	48	(	(	-LRB-
cord-296347-fanlvxqs	632	49	Fig	Fig	NNP
cord-296347-fanlvxqs	632	50	.	.	NNP
cord-296347-fanlvxqs	632	51	6	6	CD
cord-296347-fanlvxqs	632	52	,	,	,
cord-296347-fanlvxqs	632	53	A	a	DT
cord-296347-fanlvxqs	632	54	arrow	arrow	NN
cord-296347-fanlvxqs	632	55	)	)	-RRB-
cord-296347-fanlvxqs	632	56	.	.	.
cord-296347-fanlvxqs	633	1	Experi	Experi	NNP
cord-296347-fanlvxqs	633	2	ments	ment	NNS
cord-296347-fanlvxqs	633	3	to	to	TO
cord-296347-fanlvxqs	633	4	address	address	VB
cord-296347-fanlvxqs	633	5	the	the	DT
cord-296347-fanlvxqs	633	6	identity	identity	NN
cord-296347-fanlvxqs	633	7	of	of	IN
cord-296347-fanlvxqs	633	8	SPP	spp	NN
cord-296347-fanlvxqs	633	9	-	-	HYPH
cord-296347-fanlvxqs	633	10	associated	associate	VBN
cord-296347-fanlvxqs	633	11	proteins	protein	NNS
cord-296347-fanlvxqs	633	12	may	may	MD
cord-296347-fanlvxqs	633	13	prove	prove	VB
cord-296347-fanlvxqs	633	14	informative	informative	JJ
cord-296347-fanlvxqs	633	15	.	.	.
cord-296347-fanlvxqs	634	1	Curiously	curiously	RB
cord-296347-fanlvxqs	634	2	,	,	,
cord-296347-fanlvxqs	634	3	another	another	DT
cord-296347-fanlvxqs	634	4	class	class	NN
cord-296347-fanlvxqs	634	5	of	of	IN
cord-296347-fanlvxqs	634	6	intramembrane	intramembrane	NN
cord-296347-fanlvxqs	634	7	-	-	HYPH
cord-296347-fanlvxqs	634	8	cleaving	cleave	VBG
cord-296347-fanlvxqs	634	9	proteases	protease	NNS
cord-296347-fanlvxqs	634	10	,	,	,
cord-296347-fanlvxqs	634	11	the	the	DT
cord-296347-fanlvxqs	634	12	rhomboid	rhomboid	JJ
cord-296347-fanlvxqs	634	13	serine	serine	NN
cord-296347-fanlvxqs	634	14	proteases	protease	NNS
cord-296347-fanlvxqs	634	15	,	,	,
cord-296347-fanlvxqs	634	16	share	share	VBP
cord-296347-fanlvxqs	634	17	a	a	DT
cord-296347-fanlvxqs	634	18	homology	homology	NN
cord-296347-fanlvxqs	634	19	domain	domain	NN
cord-296347-fanlvxqs	634	20	of	of	IN
cord-296347-fanlvxqs	634	21	unknown	unknown	JJ
cord-296347-fanlvxqs	634	22	function	function	NN
cord-296347-fanlvxqs	634	23	with	with	IN
cord-296347-fanlvxqs	634	24	the	the	DT
cord-296347-fanlvxqs	634	25	Derlins	Derlins	NNP
cord-296347-fanlvxqs	634	26	(	(	-LRB-
cord-296347-fanlvxqs	634	27	Lemberg	Lemberg	NNP
cord-296347-fanlvxqs	634	28	et	et	FW
cord-296347-fanlvxqs	634	29	al	al	NNP
cord-296347-fanlvxqs	634	30	.	.	NNP
cord-296347-fanlvxqs	634	31	,	,	,
cord-296347-fanlvxqs	634	32	2005	2005	CD
cord-296347-fanlvxqs	634	33	)	)	-RRB-
cord-296347-fanlvxqs	634	34	.	.	.
cord-296347-fanlvxqs	635	1	It	-PRON-	PRP
cord-296347-fanlvxqs	635	2	is	be	VBZ
cord-296347-fanlvxqs	635	3	tempting	tempt	VBG
cord-296347-fanlvxqs	635	4	to	to	TO
cord-296347-fanlvxqs	635	5	speculate	speculate	VB
cord-296347-fanlvxqs	635	6	that	that	IN
cord-296347-fanlvxqs	635	7	our	-PRON-	PRP$
cord-296347-fanlvxqs	635	8	observations	observation	NNS
cord-296347-fanlvxqs	635	9	extend	extend	VBP
cord-296347-fanlvxqs	635	10	the	the	DT
cord-296347-fanlvxqs	635	11	connection	connection	NN
cord-296347-fanlvxqs	635	12	from	from	IN
cord-296347-fanlvxqs	635	13	regulated	regulate	VBN
cord-296347-fanlvxqs	635	14	intramembrane	intramembrane	NNP
cord-296347-fanlvxqs	635	15	proteolysis	proteolysis	NN
cord-296347-fanlvxqs	635	16	to	to	IN
cord-296347-fanlvxqs	635	17	a	a	DT
cord-296347-fanlvxqs	635	18	direct	direct	JJ
cord-296347-fanlvxqs	635	19	involvement	involvement	NN
cord-296347-fanlvxqs	635	20	in	in	IN
cord-296347-fanlvxqs	635	21	ER	ER	NNP
cord-296347-fanlvxqs	635	22	dislocation	dislocation	NN
cord-296347-fanlvxqs	635	23	.	.	.
cord-296347-fanlvxqs	636	1	An	an	DT
cord-296347-fanlvxqs	636	2	involvement	involvement	NN
cord-296347-fanlvxqs	636	3	of	of	IN
cord-296347-fanlvxqs	636	4	SPP	SPP	NNS
cord-296347-fanlvxqs	636	5	with	with	IN
cord-296347-fanlvxqs	636	6	the	the	DT
cord-296347-fanlvxqs	636	7	UPR	UPR	NNP
cord-296347-fanlvxqs	636	8	is	be	VBZ
cord-296347-fanlvxqs	636	9	also	also	RB
cord-296347-fanlvxqs	636	10	a	a	DT
cord-296347-fanlvxqs	636	11	possibility	possibility	NN
cord-296347-fanlvxqs	636	12	.	.	.
cord-296347-fanlvxqs	637	1	Cells	cell	NNS
cord-296347-fanlvxqs	637	2	deficient	deficient	JJ
cord-296347-fanlvxqs	637	3	for	for	IN
cord-296347-fanlvxqs	638	1	the	the	DT
cord-296347-fanlvxqs	638	2	X	X	NNP
cord-296347-fanlvxqs	638	3	-	-	HYPH
cord-296347-fanlvxqs	638	4	box	box	NN
cord-296347-fanlvxqs	638	5	binding	bind	VBG
cord-296347-fanlvxqs	638	6	protein-1	protein-1	NNP
cord-296347-fanlvxqs	638	7	transcription	transcription	NN
cord-296347-fanlvxqs	638	8	factor	factor	NN
cord-296347-fanlvxqs	638	9	(	(	-LRB-
cord-296347-fanlvxqs	638	10	XBP-1	XBP-1	NNP
cord-296347-fanlvxqs	638	11	)	)	-RRB-
cord-296347-fanlvxqs	638	12	show	show	VBP
cord-296347-fanlvxqs	638	13	upregulated	upregulate	VBN
cord-296347-fanlvxqs	638	14	levels	level	NNS
cord-296347-fanlvxqs	638	15	of	of	IN
cord-296347-fanlvxqs	638	16	SPP	spp	NN
cord-296347-fanlvxqs	638	17	transcripts	transcript	NNS
cord-296347-fanlvxqs	638	18	(	(	-LRB-
cord-296347-fanlvxqs	638	19	Shaffer	Shaffer	NNP
cord-296347-fanlvxqs	638	20	et	et	NNP
cord-296347-fanlvxqs	638	21	al	al	NNP
cord-296347-fanlvxqs	638	22	.	.	NNP
cord-296347-fanlvxqs	638	23	,	,	,
cord-296347-fanlvxqs	638	24	2004	2004	CD
cord-296347-fanlvxqs	638	25	)	)	-RRB-
cord-296347-fanlvxqs	638	26	,	,	,
cord-296347-fanlvxqs	638	27	but	but	CC
cord-296347-fanlvxqs	638	28	this	this	DT
cord-296347-fanlvxqs	638	29	aspect	aspect	NN
cord-296347-fanlvxqs	638	30	of	of	IN
cord-296347-fanlvxqs	638	31	the	the	DT
cord-296347-fanlvxqs	638	32	process	process	NN
cord-296347-fanlvxqs	638	33	remains	remain	VBZ
cord-296347-fanlvxqs	638	34	to	to	TO
cord-296347-fanlvxqs	638	35	be	be	VB
cord-296347-fanlvxqs	638	36	explored	explore	VBN
cord-296347-fanlvxqs	638	37	.	.	.
cord-296347-fanlvxqs	639	1	Although	although	IN
cord-296347-fanlvxqs	639	2	removal	removal	NN
cord-296347-fanlvxqs	639	3	of	of	IN
cord-296347-fanlvxqs	639	4	signal	signal	NN
cord-296347-fanlvxqs	639	5	peptide	peptide	NN
cord-296347-fanlvxqs	639	6	remnants	remnant	NNS
cord-296347-fanlvxqs	639	7	from	from	IN
cord-296347-fanlvxqs	639	8	the	the	DT
cord-296347-fanlvxqs	639	9	ER	ER	NNP
cord-296347-fanlvxqs	639	10	membrane	membrane	NN
cord-296347-fanlvxqs	639	11	,	,	,
cord-296347-fanlvxqs	639	12	assigned	assign	VBN
cord-296347-fanlvxqs	639	13	to	to	IN
cord-296347-fanlvxqs	639	14	SPP	SPP	NNS
cord-296347-fanlvxqs	639	15	in	in	IN
cord-296347-fanlvxqs	639	16	animals	animal	NNS
cord-296347-fanlvxqs	639	17	and	and	CC
cord-296347-fanlvxqs	639	18	plants	plant	NNS
cord-296347-fanlvxqs	639	19	,	,	,
cord-296347-fanlvxqs	639	20	is	be	VBZ
cord-296347-fanlvxqs	639	21	not	not	RB
cord-296347-fanlvxqs	639	22	a	a	DT
cord-296347-fanlvxqs	639	23	function	function	NN
cord-296347-fanlvxqs	639	24	exclusive	exclusive	JJ
cord-296347-fanlvxqs	639	25	to	to	IN
cord-296347-fanlvxqs	639	26	higher	high	JJR
cord-296347-fanlvxqs	639	27	eukaryotes	eukaryote	NNS
cord-296347-fanlvxqs	639	28	,	,	,
cord-296347-fanlvxqs	639	29	a	a	DT
cord-296347-fanlvxqs	639	30	gene	gene	NN
cord-296347-fanlvxqs	639	31	that	that	WDT
cord-296347-fanlvxqs	639	32	encodes	encode	VBZ
cord-296347-fanlvxqs	639	33	an	an	DT
cord-296347-fanlvxqs	639	34	orthologue	orthologue	NN
cord-296347-fanlvxqs	639	35	of	of	IN
cord-296347-fanlvxqs	639	36	this	this	DT
cord-296347-fanlvxqs	639	37	enzyme	enzyme	NN
cord-296347-fanlvxqs	639	38	is	be	VBZ
cord-296347-fanlvxqs	639	39	absent	absent	JJ
cord-296347-fanlvxqs	639	40	from	from	IN
cord-296347-fanlvxqs	639	41	the	the	DT
cord-296347-fanlvxqs	639	42	yeast	yeast	NN
cord-296347-fanlvxqs	639	43	genome	genome	NN
cord-296347-fanlvxqs	639	44	(	(	-LRB-
cord-296347-fanlvxqs	639	45	Martoglio	Martoglio	NNP
cord-296347-fanlvxqs	639	46	,	,	,
cord-296347-fanlvxqs	639	47	2003	2003	CD
cord-296347-fanlvxqs	639	48	;	;	:
cord-296347-fanlvxqs	640	1	Weihofen	Weihofen	NNP
cord-296347-fanlvxqs	640	2	et	et	NNP
cord-296347-fanlvxqs	640	3	al	al	NNP
cord-296347-fanlvxqs	640	4	.	.	NNP
cord-296347-fanlvxqs	640	5	,	,	,
cord-296347-fanlvxqs	640	6	2002	2002	CD
cord-296347-fanlvxqs	640	7	)	)	-RRB-
cord-296347-fanlvxqs	640	8	.	.	.
cord-296347-fanlvxqs	641	1	The	the	DT
cord-296347-fanlvxqs	641	2	role	role	NN
cord-296347-fanlvxqs	641	3	of	of	IN
cord-296347-fanlvxqs	641	4	SPP	SPP	NNP
cord-296347-fanlvxqs	641	5	in	in	IN
cord-296347-fanlvxqs	641	6	higher	high	JJR
cord-296347-fanlvxqs	641	7	eukaryotes	eukaryote	NNS
cord-296347-fanlvxqs	641	8	might	may	MD
cord-296347-fanlvxqs	641	9	therefore	therefore	RB
cord-296347-fanlvxqs	641	10	not	not	RB
cord-296347-fanlvxqs	641	11	be	be	VB
cord-296347-fanlvxqs	641	12	limited	limit	VBN
cord-296347-fanlvxqs	641	13	to	to	TO
cord-296347-fanlvxqs	641	14	signal	signal	VB
cord-296347-fanlvxqs	641	15	peptide	peptide	NN
cord-296347-fanlvxqs	641	16	processing	processing	NN
cord-296347-fanlvxqs	641	17	but	but	CC
cord-296347-fanlvxqs	641	18	extend	extend	VB
cord-296347-fanlvxqs	641	19	to	to	IN
cord-296347-fanlvxqs	641	20	processes	process	NNS
cord-296347-fanlvxqs	641	21	such	such	JJ
cord-296347-fanlvxqs	641	22	as	as	IN
cord-296347-fanlvxqs	641	23	protein	protein	NN
cord-296347-fanlvxqs	641	24	dislocation	dislocation	NN
cord-296347-fanlvxqs	641	25	from	from	IN
cord-296347-fanlvxqs	641	26	the	the	DT
cord-296347-fanlvxqs	641	27	ER	ER	NNP
cord-296347-fanlvxqs	641	28	.	.	.
cord-296347-fanlvxqs	642	1	PS	PS	NNP
cord-296347-fanlvxqs	642	2	and	and	CC
cord-296347-fanlvxqs	642	3	the	the	DT
cord-296347-fanlvxqs	642	4	other	other	JJ
cord-296347-fanlvxqs	642	5	SPP	spp	NN
cord-296347-fanlvxqs	642	6	-	-	HYPH
cord-296347-fanlvxqs	642	7	like	like	JJ
cord-296347-fanlvxqs	642	8	members	member	NNS
cord-296347-fanlvxqs	642	9	of	of	IN
cord-296347-fanlvxqs	642	10	the	the	DT
cord-296347-fanlvxqs	642	11	PS	PS	NNP
cord-296347-fanlvxqs	642	12	/	/	SYM
cord-296347-fanlvxqs	642	13	SPPL	SPPL	NNP
cord-296347-fanlvxqs	642	14	superfamily	superfamily	NN
cord-296347-fanlvxqs	642	15	of	of	IN
cord-296347-fanlvxqs	642	16	intramembrane	intramembrane	NNP
cord-296347-fanlvxqs	642	17	-	-	HYPH
cord-296347-fanlvxqs	642	18	cleaving	cleave	VBG
cord-296347-fanlvxqs	642	19	aspartic	aspartic	JJ
cord-296347-fanlvxqs	642	20	proteases	protease	NNS
cord-296347-fanlvxqs	642	21	,	,	,
cord-296347-fanlvxqs	642	22	so	so	RB
cord-296347-fanlvxqs	642	23	far	far	RB
cord-296347-fanlvxqs	642	24	of	of	IN
cord-296347-fanlvxqs	642	25	unknown	unknown	JJ
cord-296347-fanlvxqs	642	26	function	function	NN
cord-296347-fanlvxqs	642	27	(	(	-LRB-
cord-296347-fanlvxqs	642	28	Martoglio	Martoglio	NNP
cord-296347-fanlvxqs	642	29	and	and	CC
cord-296347-fanlvxqs	642	30	Golde	Golde	NNP
cord-296347-fanlvxqs	642	31	,	,	,
cord-296347-fanlvxqs	642	32	2003	2003	CD
cord-296347-fanlvxqs	642	33	)	)	-RRB-
cord-296347-fanlvxqs	642	34	,	,	,
cord-296347-fanlvxqs	642	35	and	and	CC
cord-296347-fanlvxqs	642	36	some	some	DT
cord-296347-fanlvxqs	642	37	of	of	IN
cord-296347-fanlvxqs	642	38	which	which	WDT
cord-296347-fanlvxqs	642	39	may	may	MD
cord-296347-fanlvxqs	642	40	not	not	RB
cord-296347-fanlvxqs	642	41	reside	reside	VB
cord-296347-fanlvxqs	642	42	in	in	IN
cord-296347-fanlvxqs	642	43	the	the	DT
cord-296347-fanlvxqs	642	44	ER	er	NN
cord-296347-fanlvxqs	643	1	(	(	-LRB-
cord-296347-fanlvxqs	643	2	Krawitz	Krawitz	NNP
cord-296347-fanlvxqs	643	3	et	et	NNP
cord-296347-fanlvxqs	643	4	al	al	NNP
cord-296347-fanlvxqs	643	5	.	.	NNP
cord-296347-fanlvxqs	643	6	,	,	,
cord-296347-fanlvxqs	643	7	2005	2005	CD
cord-296347-fanlvxqs	643	8	)	)	-RRB-
cord-296347-fanlvxqs	643	9	,	,	,
cord-296347-fanlvxqs	643	10	may	may	MD
cord-296347-fanlvxqs	643	11	likewise	likewise	RB
cord-296347-fanlvxqs	643	12	be	be	VB
cord-296347-fanlvxqs	643	13	involved	involve	VBN
cord-296347-fanlvxqs	643	14	in	in	IN
cord-296347-fanlvxqs	643	15	disposal	disposal	NN
cord-296347-fanlvxqs	643	16	of	of	IN
cord-296347-fanlvxqs	643	17	different	different	JJ
cord-296347-fanlvxqs	643	18	degradation	degradation	NN
cord-296347-fanlvxqs	643	19	substrates	substrate	NNS
cord-296347-fanlvxqs	643	20	.	.	.
cord-296347-fanlvxqs	644	1	HCMV	HCMV	NNP
cord-296347-fanlvxqs	644	2	might	may	MD
cord-296347-fanlvxqs	644	3	just	just	RB
cord-296347-fanlvxqs	644	4	be	be	VB
cord-296347-fanlvxqs	644	5	exploiting	exploit	VBG
cord-296347-fanlvxqs	644	6	a	a	DT
cord-296347-fanlvxqs	644	7	cellular	cellular	JJ
cord-296347-fanlvxqs	644	8	degradation	degradation	NN
cord-296347-fanlvxqs	644	9	pathway	pathway	NN
cord-296347-fanlvxqs	644	10	that	that	WDT
cord-296347-fanlvxqs	644	11	involves	involve	VBZ
cord-296347-fanlvxqs	644	12	intramembrane	intramembrane	NN
cord-296347-fanlvxqs	644	13	-	-	HYPH
cord-296347-fanlvxqs	644	14	cleaving	cleave	VBG
cord-296347-fanlvxqs	644	15	proteases	protease	NNS
cord-296347-fanlvxqs	644	16	for	for	IN
cord-296347-fanlvxqs	644	17	disposal	disposal	NN
cord-296347-fanlvxqs	644	18	of	of	IN
cord-296347-fanlvxqs	644	19	class	class	NN
cord-296347-fanlvxqs	644	20	I	-PRON-	PRP
cord-296347-fanlvxqs	644	21	MHC	MHC	NNP
cord-296347-fanlvxqs	644	22	HC	HC	NNP
cord-296347-fanlvxqs	644	23	.	.	.
cord-296347-fanlvxqs	645	1	The	the	DT
cord-296347-fanlvxqs	645	2	US2	US2	NNP
cord-296347-fanlvxqs	645	3	TMD	TMD	NNP
cord-296347-fanlvxqs	645	4	,	,	,
cord-296347-fanlvxqs	645	5	although	although	IN
cord-296347-fanlvxqs	645	6	dispensable	dispensable	JJ
cord-296347-fanlvxqs	645	7	for	for	IN
cord-296347-fanlvxqs	645	8	interaction	interaction	NN
cord-296347-fanlvxqs	645	9	with	with	IN
cord-296347-fanlvxqs	645	10	SPP	SPP	NNP
cord-296347-fanlvxqs	645	11	,	,	,
cord-296347-fanlvxqs	645	12	is	be	VBZ
cord-296347-fanlvxqs	645	13	also	also	RB
cord-296347-fanlvxqs	645	14	required	require	VBN
cord-296347-fanlvxqs	645	15	for	for	IN
cord-296347-fanlvxqs	645	16	HC	HC	NNP
cord-296347-fanlvxqs	645	17	dislocation	dislocation	NN
cord-296347-fanlvxqs	645	18	(	(	-LRB-
cord-296347-fanlvxqs	645	19	Loureiro	Loureiro	NNP
cord-296347-fanlvxqs	645	20	et	et	FW
cord-296347-fanlvxqs	645	21	al	al	NNP
cord-296347-fanlvxqs	645	22	.	.	NNP
cord-296347-fanlvxqs	645	23	,	,	,
cord-296347-fanlvxqs	645	24	2006	2006	CD
cord-296347-fanlvxqs	645	25	)	)	-RRB-
cord-296347-fanlvxqs	645	26	.	.	.
cord-296347-fanlvxqs	646	1	HC	HC	NNP
cord-296347-fanlvxqs	646	2	dislocation	dislocation	NN
cord-296347-fanlvxqs	646	3	is	be	VBZ
cord-296347-fanlvxqs	646	4	therefore	therefore	RB
cord-296347-fanlvxqs	646	5	dependent	dependent	JJ
cord-296347-fanlvxqs	646	6	not	not	RB
cord-296347-fanlvxqs	646	7	just	just	RB
cord-296347-fanlvxqs	646	8	on	on	IN
cord-296347-fanlvxqs	646	9	(	(	-LRB-
cord-296347-fanlvxqs	646	10	US2	US2	NNP
cord-296347-fanlvxqs	646	11	tail	tail	NN
cord-296347-fanlvxqs	646	12	-	-	HYPH
cord-296347-fanlvxqs	646	13	mediated	mediate	VBN
cord-296347-fanlvxqs	646	14	)	)	-RRB-
cord-296347-fanlvxqs	646	15	recruitment	recruitment	NN
cord-296347-fanlvxqs	646	16	of	of	IN
cord-296347-fanlvxqs	646	17	SPP	SPP	NNP
cord-296347-fanlvxqs	646	18	,	,	,
cord-296347-fanlvxqs	646	19	but	but	CC
cord-296347-fanlvxqs	646	20	also	also	RB
cord-296347-fanlvxqs	646	21	on	on	IN
cord-296347-fanlvxqs	646	22	additional	additional	JJ
cord-296347-fanlvxqs	646	23	(	(	-LRB-
cord-296347-fanlvxqs	646	24	US2	US2	NNP
cord-296347-fanlvxqs	646	25	TMD	TMD	NNP
cord-296347-fanlvxqs	646	26	-	-	HYPH
cord-296347-fanlvxqs	646	27	mediated	mediate	VBN
cord-296347-fanlvxqs	646	28	)	)	-RRB-
cord-296347-fanlvxqs	646	29	interactions	interaction	NNS
cord-296347-fanlvxqs	646	30	within	within	IN
cord-296347-fanlvxqs	646	31	the	the	DT
cord-296347-fanlvxqs	646	32	plane	plane	NN
cord-296347-fanlvxqs	646	33	of	of	IN
cord-296347-fanlvxqs	646	34	the	the	DT
cord-296347-fanlvxqs	646	35	membrane	membrane	NN
cord-296347-fanlvxqs	646	36	.	.	.
cord-296347-fanlvxqs	647	1	The	the	DT
cord-296347-fanlvxqs	647	2	US2	US2	NNP
cord-296347-fanlvxqs	647	3	TMD	TMD	NNP
cord-296347-fanlvxqs	647	4	may	may	MD
cord-296347-fanlvxqs	647	5	be	be	VB
cord-296347-fanlvxqs	647	6	involved	involve	VBN
cord-296347-fanlvxqs	647	7	in	in	IN
cord-296347-fanlvxqs	647	8	further	further	JJ
cord-296347-fanlvxqs	647	9	engagement	engagement	NN
cord-296347-fanlvxqs	647	10	of	of	IN
cord-296347-fanlvxqs	647	11	SPP	SPP	NNP
cord-296347-fanlvxqs	647	12	(	(	-LRB-
cord-296347-fanlvxqs	647	13	SPPmediated	SPPmediated	NNP
cord-296347-fanlvxqs	647	14	cleava	cleava	NNP
cord-296347-fanlvxqs	647	15	ge	ge	NNP
cord-296347-fanlvxqs	647	16	or	or	CC
cord-296347-fanlvxqs	647	17	o	o	NNP
cord-296347-fanlvxqs	647	18	therwise	therwise	NNP
cord-296347-fanlvxqs	647	19	)	)	-RRB-
cord-296347-fanlvxqs	648	1	(	(	-LRB-
cord-296347-fanlvxqs	648	2	Fig	Fig	NNP
cord-296347-fanlvxqs	648	3	.	.	NNP
cord-296347-fanlvxqs	648	4	6	6	CD
cord-296347-fanlvxqs	648	5	,	,	,
cord-296347-fanlvxqs	648	6	B	b	NN
cord-296347-fanlvxqs	648	7	arrow	arrow	NN
cord-296347-fanlvxqs	648	8	)	)	-RRB-
cord-296347-fanlvxqs	648	9	,	,	,
cord-296347-fanlvxqs	648	10	o	o	UH
cord-296347-fanlvxqs	648	11	r	r	NNP
cord-296347-fanlvxqs	648	12	alternativ	alternativ	NNP
cord-296347-fanlvxqs	648	13	ely	ely	NNP
cord-296347-fanlvxqs	648	14	,	,	,
cord-296347-fanlvxqs	648	15	in	in	IN
cord-296347-fanlvxqs	648	16	the	the	DT
cord-296347-fanlvxqs	648	17	recruitment	recruitment	NN
cord-296347-fanlvxqs	648	18	or	or	CC
cord-296347-fanlvxqs	648	19	engagement	engagement	NN
cord-296347-fanlvxqs	648	20	of	of	IN
cord-296347-fanlvxqs	648	21	other	other	JJ
cord-296347-fanlvxqs	648	22	protein(s	protein(s	NNP
cord-296347-fanlvxqs	648	23	)	)	-RRB-
cord-296347-fanlvxqs	648	24	involved	involve	VBN
cord-296347-fanlvxqs	648	25	in	in	IN
cord-296347-fanlvxqs	648	26	dislocation	dislocation	NN
cord-296347-fanlvxqs	648	27	(	(	-LRB-
cord-296347-fanlvxqs	648	28	Fig	Fig	NNP
cord-296347-fanlvxqs	648	29	.	.	NNP
cord-296347-fanlvxqs	648	30	6	6	CD
cord-296347-fanlvxqs	648	31	,	,	,
cord-296347-fanlvxqs	648	32	C	C	NNP
cord-296347-fanlvxqs	648	33	arrow	arrow	NN
cord-296347-fanlvxqs	648	34	)	)	-RRB-
cord-296347-fanlvxqs	648	35	.	.	.
cord-296347-fanlvxqs	649	1	ER	ER	NNP
cord-296347-fanlvxqs	649	2	m	m	NNP
cord-296347-fanlvxqs	649	3	embran	embran	NN
cord-296347-fanlvxqs	649	4	e	e	NN
cord-296347-fanlvxqs	649	5	E3s	e3s	NN
cord-296347-fanlvxqs	649	6	or	or	CC
cord-296347-fanlvxqs	649	7	their	-PRON-	PRP$
cord-296347-fanlvxqs	649	8	adap	adap	NN
cord-296347-fanlvxqs	649	9	tor	tor	NN
cord-296347-fanlvxqs	649	10	subunits	subunit	NNS
cord-296347-fanlvxqs	649	11	are	be	VBP
cord-296347-fanlvxqs	649	12	like	like	IN
cord-296347-fanlvxqs	649	13	ly	ly	NNP
cord-296347-fanlvxqs	649	14	cand	cand	NNP
cord-296347-fanlvxqs	649	15	idates	idate	NNS
cord-296347-fanlvxqs	649	16	.	.	.
cord-296347-fanlvxqs	650	1	SPP	SPP	NNP
cord-296347-fanlvxqs	650	2	is	be	VBZ
cord-296347-fanlvxqs	650	3	most	most	RBS
cord-296347-fanlvxqs	650	4	certainly	certainly	RB
cord-296347-fanlvxqs	650	5	not	not	RB
cord-296347-fanlvxqs	650	6	the	the	DT
cord-296347-fanlvxqs	650	7	sole	sole	JJ
cord-296347-fanlvxqs	650	8	host	host	NN
cord-296347-fanlvxqs	650	9	-	-	HYPH
cord-296347-fanlvxqs	650	10	derived	derive	VBN
cord-296347-fanlvxqs	650	11	component	component	NN
cord-296347-fanlvxqs	650	12	of	of	IN
cord-296347-fanlvxqs	650	13	the	the	DT
cord-296347-fanlvxqs	650	14	US2	US2	NNP
cord-296347-fanlvxqs	650	15	dislocation	dislocation	NN
cord-296347-fanlvxqs	650	16	pathway	pathway	NN
cord-296347-fanlvxqs	650	17	,	,	,
cord-296347-fanlvxqs	650	18	and	and	CC
cord-296347-fanlvxqs	650	19	a	a	DT
cord-296347-fanlvxqs	650	20	putative	putative	JJ
cord-296347-fanlvxqs	650	21	multiprotein	multiprotein	NN
cord-296347-fanlvxqs	650	22	complex	complex	JJ
cord-296347-fanlvxqs	650	23	(	(	-LRB-
cord-296347-fanlvxqs	650	24	cascade	cascade	NN
cord-296347-fanlvxqs	650	25	of	of	IN
cord-296347-fanlvxqs	650	26	adaptor	adaptor	NN
cord-296347-fanlvxqs	650	27	proteins	protein	NNS
cord-296347-fanlvxqs	650	28	)	)	-RRB-
cord-296347-fanlvxqs	650	29	analogous	analogous	JJ
cord-296347-fanlvxqs	650	30	to	to	IN
cord-296347-fanlvxqs	650	31	that	that	DT
cord-296347-fanlvxqs	650	32	found	find	VBN
cord-296347-fanlvxqs	650	33	for	for	IN
cord-296347-fanlvxqs	650	34	US11	US11	NNP
cord-296347-fanlvxqs	650	35	is	be	VBZ
cord-296347-fanlvxqs	650	36	likely	likely	JJ
cord-296347-fanlvxqs	650	37	to	to	TO
cord-296347-fanlvxqs	650	38	be	be	VB
cord-296347-fanlvxqs	650	39	found	find	VBN
cord-296347-fanlvxqs	650	40	that	that	WDT
cord-296347-fanlvxqs	650	41	evokes	evoke	VBZ
cord-296347-fanlvxqs	650	42	many	many	JJ
cord-296347-fanlvxqs	650	43	(	(	-LRB-
cord-296347-fanlvxqs	650	44	complicated	complicated	JJ
cord-296347-fanlvxqs	650	45	)	)	-RRB-
cord-296347-fanlvxqs	650	46	links	link	NNS
cord-296347-fanlvxqs	650	47	between	between	IN
cord-296347-fanlvxqs	650	48	the	the	DT
cord-296347-fanlvxqs	650	49	ERAD	ERAD	NNP
cord-296347-fanlvxqs	650	50	machineries	machinery	NNS
cord-296347-fanlvxqs	650	51	at	at	IN
cord-296347-fanlvxqs	650	52	the	the	DT
cord-296347-fanlvxqs	650	53	level	level	NN
cord-296347-fanlvxqs	650	54	of	of	IN
cord-296347-fanlvxqs	650	55	the	the	DT
cord-296347-fanlvxqs	650	56	ER	ER	NNP
cord-296347-fanlvxqs	650	57	membrane	membrane	NN
cord-296347-fanlvxqs	650	58	and	and	CC
cord-296347-fanlvxqs	650	59	the	the	DT
cord-296347-fanlvxqs	650	60	cytosol	cytosol	NN
cord-296347-fanlvxqs	650	61	.	.	.
cord-296347-fanlvxqs	651	1	Uncovering	uncover	VBG
cord-296347-fanlvxqs	651	2	the	the	DT
cord-296347-fanlvxqs	651	3	identity	identity	NN
cord-296347-fanlvxqs	651	4	of	of	IN
cord-296347-fanlvxqs	651	5	the	the	DT
cord-296347-fanlvxqs	651	6	additional	additional	JJ
cord-296347-fanlvxqs	651	7	cellular	cellular	JJ
cord-296347-fanlvxqs	651	8	partners	partner	NNS
cord-296347-fanlvxqs	651	9	of	of	IN
cord-296347-fanlvxqs	651	10	this	this	DT
cord-296347-fanlvxqs	651	11	HCMV	HCMV	NNP
cord-296347-fanlvxqs	651	12	US2	US2	NNP
cord-296347-fanlvxqs	651	13	immunoevasin	immunoevasin	NNS
cord-296347-fanlvxqs	651	14	will	will	MD
cord-296347-fanlvxqs	651	15	certainly	certainly	RB
cord-296347-fanlvxqs	651	16	give	give	VB
cord-296347-fanlvxqs	651	17	us	-PRON-	PRP
cord-296347-fanlvxqs	651	18	insight	insight	NN
cord-296347-fanlvxqs	651	19	into	into	IN
cord-296347-fanlvxqs	651	20	the	the	DT
cord-296347-fanlvxqs	651	21	dislocation	dislocation	NN
cord-296347-fanlvxqs	651	22	mechanism	mechanism	NN
cord-296347-fanlvxqs	651	23	.	.	.
cord-296347-fanlvxqs	651	24	 	 	_SP
cord-296347-fanlvxqs	652	1	A	a	DT
cord-296347-fanlvxqs	652	2	theme	theme	NN
cord-296347-fanlvxqs	652	3	that	that	WDT
cord-296347-fanlvxqs	652	4	arises	arise	VBZ
cord-296347-fanlvxqs	652	5	from	from	IN
cord-296347-fanlvxqs	652	6	analysis	analysis	NN
cord-296347-fanlvxqs	652	7	of	of	IN
cord-296347-fanlvxqs	652	8	the	the	DT
cord-296347-fanlvxqs	652	9	US2-and	US2-and	NNP
cord-296347-fanlvxqs	652	10	US11-mediated	us11-mediated	CD
cord-296347-fanlvxqs	652	11	HC	HC	NNP
cord-296347-fanlvxqs	652	12	dislocation	dislocation	NN
cord-296347-fanlvxqs	652	13	processes	process	NNS
cord-296347-fanlvxqs	652	14	is	be	VBZ
cord-296347-fanlvxqs	652	15	that	that	IN
cord-296347-fanlvxqs	652	16	these	these	DT
cord-296347-fanlvxqs	652	17	are	be	VBP
cord-296347-fanlvxqs	652	18	only	only	RB
cord-296347-fanlvxqs	652	19	superficially	superficially	RB
cord-296347-fanlvxqs	652	20	similar	similar	JJ
cord-296347-fanlvxqs	652	21	:	:	:
cord-296347-fanlvxqs	652	22	although	although	IN
cord-296347-fanlvxqs	652	23	HC	HC	NNP
cord-296347-fanlvxqs	652	24	dislocation	dislocation	NN
cord-296347-fanlvxqs	652	25	by	by	IN
cord-296347-fanlvxqs	652	26	US2	US2	NNP
cord-296347-fanlvxqs	652	27	and	and	CC
cord-296347-fanlvxqs	652	28	US11	US11	NNP
cord-296347-fanlvxqs	652	29	has	have	VBZ
cord-296347-fanlvxqs	652	30	the	the	DT
cord-296347-fanlvxqs	652	31	same	same	JJ
cord-296347-fanlvxqs	652	32	outcome	outcome	NN
cord-296347-fanlvxqs	652	33	(	(	-LRB-
cord-296347-fanlvxqs	652	34	proteasomal	proteasomal	JJ
cord-296347-fanlvxqs	652	35	degradation	degradation	NN
cord-296347-fanlvxqs	652	36	)	)	-RRB-
cord-296347-fanlvxqs	652	37	of	of	IN
cord-296347-fanlvxqs	652	38	HC	HC	NNP
cord-296347-fanlvxqs	652	39	and	and	CC
cord-296347-fanlvxqs	652	40	shares	share	NNS
cord-296347-fanlvxqs	652	41	many	many	JJ
cord-296347-fanlvxqs	652	42	if	if	IN
cord-296347-fanlvxqs	652	43	not	not	RB
cord-296347-fanlvxqs	652	44	all	all	DT
cord-296347-fanlvxqs	652	45	of	of	IN
cord-296347-fanlvxqs	652	46	the	the	DT
cord-296347-fanlvxqs	652	47	steps	step	NNS
cord-296347-fanlvxqs	652	48	that	that	WDT
cord-296347-fanlvxqs	652	49	take	take	VBP
cord-296347-fanlvxqs	652	50	place	place	NN
cord-296347-fanlvxqs	652	51	after	after	IN
cord-296347-fanlvxqs	652	52	extraction	extraction	NN
cord-296347-fanlvxqs	652	53	of	of	IN
cord-296347-fanlvxqs	652	54	the	the	DT
cord-296347-fanlvxqs	652	55	HC	HC	NNP
cord-296347-fanlvxqs	652	56	from	from	IN
cord-296347-fanlvxqs	652	57	the	the	DT
cord-296347-fanlvxqs	652	58	ER	ER	NNP
cord-296347-fanlvxqs	652	59	membrane	membrane	NN
cord-296347-fanlvxqs	652	60	(	(	-LRB-
cord-296347-fanlvxqs	652	61	such	such	JJ
cord-296347-fanlvxqs	652	62	as	as	IN
cord-296347-fanlvxqs	652	63	deglycosylation	deglycosylation	NN
cord-296347-fanlvxqs	652	64	and	and	CC
cord-296347-fanlvxqs	652	65	degradation	degradation	NN
cord-296347-fanlvxqs	652	66	kinetics	kinetics	NNP
cord-296347-fanlvxqs	652	67	)	)	-RRB-
cord-296347-fanlvxqs	652	68	,	,	,
cord-296347-fanlvxqs	652	69	the	the	DT
cord-296347-fanlvxqs	652	70	differences	difference	NNS
cord-296347-fanlvxqs	652	71	between	between	IN
cord-296347-fanlvxqs	652	72	the	the	DT
cord-296347-fanlvxqs	652	73	pathways	pathway	NNS
cord-296347-fanlvxqs	652	74	are	be	VBP
cord-296347-fanlvxqs	652	75	rather	rather	RB
cord-296347-fanlvxqs	652	76	striking	strike	VBG
cord-296347-fanlvxqs	652	77	in	in	IN
cord-296347-fanlvxqs	652	78	terms	term	NNS
cord-296347-fanlvxqs	652	79	of	of	IN
cord-296347-fanlvxqs	652	80	the	the	DT
cord-296347-fanlvxqs	652	81	steps	step	NNS
cord-296347-fanlvxqs	652	82	prior	prior	RB
cord-296347-fanlvxqs	652	83	to	to	IN
cord-296347-fanlvxqs	652	84	dislocation	dislocation	NN
cord-296347-fanlvxqs	652	85	.	.	.
cord-296347-fanlvxqs	653	1	As	as	IN
cord-296347-fanlvxqs	653	2	we	-PRON-	PRP
cord-296347-fanlvxqs	653	3	mentioned	mention	VBD
cord-296347-fanlvxqs	653	4	earlier	early	RBR
cord-296347-fanlvxqs	653	5	,	,	,
cord-296347-fanlvxqs	653	6	US2	US2	NNP
cord-296347-fanlvxqs	653	7	and	and	CC
cord-296347-fanlvxqs	653	8	US11	US11	NNP
cord-296347-fanlvxqs	653	9	have	have	VBP
cord-296347-fanlvxqs	653	10	different	different	JJ
cord-296347-fanlvxqs	653	11	allele	allele	NN
cord-296347-fanlvxqs	653	12	and	and	CC
cord-296347-fanlvxqs	653	13	substrate	substrate	NN
cord-296347-fanlvxqs	653	14	folding	folding	NN
cord-296347-fanlvxqs	653	15	,	,	,
cord-296347-fanlvxqs	653	16	assembly	assembly	NN
cord-296347-fanlvxqs	653	17	,	,	,
cord-296347-fanlvxqs	653	18	and	and	CC
cord-296347-fanlvxqs	653	19	ubiquitination	ubiquitination	NN
cord-296347-fanlvxqs	653	20	requirements	requirement	NNS
cord-296347-fanlvxqs	653	21	.	.	.
cord-296347-fanlvxqs	654	1	Derlin-1	Derlin-1	NNP
cord-296347-fanlvxqs	654	2	is	be	VBZ
cord-296347-fanlvxqs	654	3	crucial	crucial	JJ
cord-296347-fanlvxqs	654	4	for	for	IN
cord-296347-fanlvxqs	654	5	US11-but	us11-but	JJ
cord-296347-fanlvxqs	654	6	not	not	RB
cord-296347-fanlvxqs	654	7	US2-mediated	us2-mediate	VBN
cord-296347-fanlvxqs	654	8	dislocation	dislocation	NN
cord-296347-fanlvxqs	654	9	of	of	IN
cord-296347-fanlvxqs	654	10	HCs	HCs	NNP
cord-296347-fanlvxqs	654	11	(	(	-LRB-
cord-296347-fanlvxqs	654	12	Lilley	Lilley	NNP
cord-296347-fanlvxqs	654	13	and	and	CC
cord-296347-fanlvxqs	654	14	Ploegh	Ploegh	NNP
cord-296347-fanlvxqs	654	15	,	,	,
cord-296347-fanlvxqs	654	16	2004	2004	CD
cord-296347-fanlvxqs	654	17	;	;	:
cord-296347-fanlvxqs	654	18	Ye	Ye	NNP
cord-296347-fanlvxqs	654	19	et	et	NNP
cord-296347-fanlvxqs	654	20	al	al	NNP
cord-296347-fanlvxqs	654	21	.	.	NNP
cord-296347-fanlvxqs	654	22	,	,	,
cord-296347-fanlvxqs	654	23	2004	2004	CD
cord-296347-fanlvxqs	654	24	)	)	-RRB-
cord-296347-fanlvxqs	654	25	,	,	,
cord-296347-fanlvxqs	654	26	and	and	CC
cord-296347-fanlvxqs	654	27	,	,	,
cord-296347-fanlvxqs	654	28	conversely	conversely	RB
cord-296347-fanlvxqs	654	29	,	,	,
cord-296347-fanlvxqs	654	30	SPP	SPP	NNP
cord-296347-fanlvxqs	654	31	is	be	VBZ
cord-296347-fanlvxqs	654	32	required	require	VBN
cord-296347-fanlvxqs	654	33	by	by	IN
cord-296347-fanlvxqs	654	34	US2	US2	NNP
cord-296347-fanlvxqs	654	35	but	but	CC
cord-296347-fanlvxqs	654	36	not	not	RB
cord-296347-fanlvxqs	654	37	by	by	IN
cord-296347-fanlvxqs	654	38	US11	US11	NNP
cord-296347-fanlvxqs	654	39	(	(	-LRB-
cord-296347-fanlvxqs	654	40	Loureiro	Loureiro	NNP
cord-296347-fanlvxqs	654	41	et	et	FW
cord-296347-fanlvxqs	654	42	al	al	NNP
cord-296347-fanlvxqs	654	43	.	.	NNP
cord-296347-fanlvxqs	654	44	,	,	,
cord-296347-fanlvxqs	654	45	2006	2006	CD
cord-296347-fanlvxqs	654	46	)	)	-RRB-
cord-296347-fanlvxqs	654	47	.	.	.
cord-296347-fanlvxqs	655	1	This	this	DT
cord-296347-fanlvxqs	655	2	suggests	suggest	VBZ
cord-296347-fanlvxqs	655	3	that	that	IN
cord-296347-fanlvxqs	655	4	the	the	DT
cord-296347-fanlvxqs	655	5	HCMV	HCMV	NNP
cord-296347-fanlvxqs	655	6	immunoevasins	immunoevasin	NNS
cord-296347-fanlvxqs	655	7	US2	US2	NNP
cord-296347-fanlvxqs	655	8	and	and	CC
cord-296347-fanlvxqs	655	9	US11	US11	NNP
cord-296347-fanlvxqs	655	10	are	be	VBP
cord-296347-fanlvxqs	655	11	targeting	target	VBG
cord-296347-fanlvxqs	655	12	HC	HC	NNP
cord-296347-fanlvxqs	655	13	molecules	molecule	NNS
cord-296347-fanlvxqs	655	14	to	to	IN
cord-296347-fanlvxqs	655	15	distinct	distinct	JJ
cord-296347-fanlvxqs	655	16	ER	ER	NNP
cord-296347-fanlvxqs	655	17	dislocation	dislocation	NN
cord-296347-fanlvxqs	655	18	pathways	pathway	NNS
cord-296347-fanlvxqs	655	19	,	,	,
cord-296347-fanlvxqs	655	20	perhaps	perhaps	RB
cord-296347-fanlvxqs	655	21	by	by	IN
cord-296347-fanlvxqs	655	22	serving	serve	VBG
cord-296347-fanlvxqs	655	23	as	as	IN
cord-296347-fanlvxqs	655	24	adaptor	adaptor	NN
cord-296347-fanlvxqs	655	25	molecules	molecule	NNS
cord-296347-fanlvxqs	655	26	aiding	aid	VBG
cord-296347-fanlvxqs	655	27	in	in	IN
cord-296347-fanlvxqs	655	28	recruitment	recruitment	NN
cord-296347-fanlvxqs	655	29	and/or	and/or	CC
cord-296347-fanlvxqs	655	30	assembly	assembly	NN
cord-296347-fanlvxqs	655	31	of	of	IN
cord-296347-fanlvxqs	655	32	distinct	distinct	JJ
cord-296347-fanlvxqs	655	33	multiprotein	multiprotein	NNP
cord-296347-fanlvxqs	655	34	complexes	complex	NNS
cord-296347-fanlvxqs	655	35	at	at	IN
cord-296347-fanlvxqs	655	36	the	the	DT
cord-296347-fanlvxqs	655	37	ER	ER	NNP
cord-296347-fanlvxqs	655	38	membrane	membrane	NN
cord-296347-fanlvxqs	655	39	Ploegh	Ploegh	NNP
cord-296347-fanlvxqs	655	40	,	,	,
cord-296347-fanlvxqs	655	41	2004	2004	CD
cord-296347-fanlvxqs	655	42	,	,	,
cord-296347-fanlvxqs	655	43	2005b	2005b	CD
cord-296347-fanlvxqs	655	44	)	)	-RRB-
cord-296347-fanlvxqs	655	45	.	.	.
cord-296347-fanlvxqs	656	1	The	the	DT
cord-296347-fanlvxqs	656	2	murine	murine	JJ
cord-296347-fanlvxqs	656	3	g	g	NN
cord-296347-fanlvxqs	656	4	-	-	HYPH
cord-296347-fanlvxqs	656	5	herpesvirus	herpesvirus	NNP
cord-296347-fanlvxqs	656	6	68	68	CD
cord-296347-fanlvxqs	656	7	(	(	-LRB-
cord-296347-fanlvxqs	656	8	MHV-68	MHV-68	NNP
cord-296347-fanlvxqs	656	9	)	)	-RRB-
cord-296347-fanlvxqs	656	10	mK3	mK3	NNP
cord-296347-fanlvxqs	656	11	also	also	RB
cord-296347-fanlvxqs	656	12	targets	target	VBZ
cord-296347-fanlvxqs	656	13	newly	newly	RB
cord-296347-fanlvxqs	656	14	synthesized	synthesize	VBN
cord-296347-fanlvxqs	656	15	murine	murine	JJ
cord-296347-fanlvxqs	656	16	class	class	NN
cord-296347-fanlvxqs	656	17	I	-PRON-	PRP
cord-296347-fanlvxqs	656	18	MHC	MHC	NNP
cord-296347-fanlvxqs	656	19	HC	HC	NNP
cord-296347-fanlvxqs	656	20	for	for	IN
cord-296347-fanlvxqs	656	21	dislocation	dislocation	NN
cord-296347-fanlvxqs	656	22	from	from	IN
cord-296347-fanlvxqs	656	23	the	the	DT
cord-296347-fanlvxqs	656	24	ER	er	NN
cord-296347-fanlvxqs	656	25	and	and	CC
cord-296347-fanlvxqs	656	26	proteasomal	proteasomal	JJ
cord-296347-fanlvxqs	656	27	degradation	degradation	NN
cord-296347-fanlvxqs	656	28	(	(	-LRB-
cord-296347-fanlvxqs	656	29	Boname	Boname	NNP
cord-296347-fanlvxqs	656	30	and	and	CC
cord-296347-fanlvxqs	656	31	Stevenson	Stevenson	NNP
cord-296347-fanlvxqs	656	32	,	,	,
cord-296347-fanlvxqs	656	33	2001	2001	CD
cord-296347-fanlvxqs	656	34	;	;	:
cord-296347-fanlvxqs	657	1	Lybarger	Lybarger	NNP
cord-296347-fanlvxqs	657	2	et	et	NNP
cord-296347-fanlvxqs	657	3	al	al	NNP
cord-296347-fanlvxqs	657	4	.	.	.
cord-296347-fanlvxqs	658	1	,	,	,
cord-296347-fanlvxqs	658	2	2005	2005	CD
cord-296347-fanlvxqs	658	3	;	;	:
cord-296347-fanlvxqs	658	4	Wang	Wang	NNP
cord-296347-fanlvxqs	658	5	et	et	NNP
cord-296347-fanlvxqs	658	6	al	al	NNP
cord-296347-fanlvxqs	658	7	.	.	.
cord-296347-fanlvxqs	659	1	,	,	,
cord-296347-fanlvxqs	659	2	2005	2005	CD
cord-296347-fanlvxqs	659	3	;	;	:
cord-296347-fanlvxqs	659	4	Yu	Yu	NNP
cord-296347-fanlvxqs	659	5	et	et	NNP
cord-296347-fanlvxqs	659	6	al	al	NNP
cord-296347-fanlvxqs	659	7	.	.	NNP
cord-296347-fanlvxqs	659	8	,	,	,
cord-296347-fanlvxqs	659	9	2002	2002	CD
cord-296347-fanlvxqs	659	10	)	)	-RRB-
cord-296347-fanlvxqs	659	11	.	.	.
cord-296347-fanlvxqs	660	1	MHV-68	MHV-68	NNP
cord-296347-fanlvxqs	661	1	mK3	mK3	NNP
cord-296347-fanlvxqs	661	2	belongs	belong	VBZ
cord-296347-fanlvxqs	661	3	to	to	IN
cord-296347-fanlvxqs	661	4	a	a	DT
cord-296347-fanlvxqs	661	5	family	family	NN
cord-296347-fanlvxqs	661	6	of	of	IN
cord-296347-fanlvxqs	661	7	structurally	structurally	RB
cord-296347-fanlvxqs	661	8	related	relate	VBN
cord-296347-fanlvxqs	661	9	molecules	molecule	NNS
cord-296347-fanlvxqs	661	10	,	,	,
cord-296347-fanlvxqs	661	11	the	the	DT
cord-296347-fanlvxqs	661	12	K3	K3	NNP
cord-296347-fanlvxqs	661	13	homologues	homologue	NNS
cord-296347-fanlvxqs	661	14	,	,	,
cord-296347-fanlvxqs	661	15	which	which	WDT
cord-296347-fanlvxqs	661	16	have	have	VBP
cord-296347-fanlvxqs	661	17	E3	E3	NNP
cord-296347-fanlvxqs	661	18	ligase	ligase	NN
cord-296347-fanlvxqs	661	19	activity	activity	NN
cord-296347-fanlvxqs	661	20	.	.	.
cord-296347-fanlvxqs	662	1	K3	K3	NNP
cord-296347-fanlvxqs	662	2	homologues	homologue	NNS
cord-296347-fanlvxqs	662	3	are	be	VBP
cord-296347-fanlvxqs	662	4	present	present	JJ
cord-296347-fanlvxqs	662	5	in	in	IN
cord-296347-fanlvxqs	662	6	several	several	JJ
cord-296347-fanlvxqs	662	7	different	different	JJ
cord-296347-fanlvxqs	662	8	g	g	NN
cord-296347-fanlvxqs	662	9	-	-	HYPH
cord-296347-fanlvxqs	662	10	herpesviruses	herpesviruses	NNP
cord-296347-fanlvxqs	662	11	and	and	CC
cord-296347-fanlvxqs	662	12	poxviruses	poxvirus	NNS
cord-296347-fanlvxqs	662	13	(	(	-LRB-
cord-296347-fanlvxqs	662	14	Coscoy	Coscoy	NNP
cord-296347-fanlvxqs	662	15	and	and	CC
cord-296347-fanlvxqs	662	16	Ganem	Ganem	NNP
cord-296347-fanlvxqs	662	17	,	,	,
cord-296347-fanlvxqs	662	18	2000	2000	CD
cord-296347-fanlvxqs	662	19	;	;	:
cord-296347-fanlvxqs	663	1	Ishido	Ishido	NNP
cord-296347-fanlvxqs	663	2	et	et	FW
cord-296347-fanlvxqs	663	3	al	al	NNP
cord-296347-fanlvxqs	663	4	.	.	.
cord-296347-fanlvxqs	664	1	,	,	,
cord-296347-fanlvxqs	664	2	2000	2000	CD
cord-296347-fanlvxqs	664	3	;	;	:
cord-296347-fanlvxqs	664	4	Mansouri	Mansouri	NNP
cord-296347-fanlvxqs	664	5	et	et	NNP
cord-296347-fanlvxqs	664	6	al	al	NNP
cord-296347-fanlvxqs	664	7	.	.	NNP
cord-296347-fanlvxqs	664	8	,	,	,
cord-296347-fanlvxqs	664	9	2003	2003	CD
cord-296347-fanlvxqs	665	1	;	;	:
cord-296347-fanlvxqs	665	2	Stevenson	Stevenson	NNP
cord-296347-fanlvxqs	665	3	et	et	NNP
cord-296347-fanlvxqs	665	4	al	al	NNP
cord-296347-fanlvxqs	665	5	.	.	NNP
cord-296347-fanlvxqs	665	6	,	,	,
cord-296347-fanlvxqs	665	7	2000	2000	CD
cord-296347-fanlvxqs	665	8	)	)	-RRB-
cord-296347-fanlvxqs	665	9	.	.	.
cord-296347-fanlvxqs	666	1	All	all	DT
cord-296347-fanlvxqs	666	2	K3	K3	NNP
cord-296347-fanlvxqs	666	3	homologues	homologue	NNS
cord-296347-fanlvxqs	666	4	possess	possess	VBP
cord-296347-fanlvxqs	666	5	a	a	DT
cord-296347-fanlvxqs	666	6	noncanonical	noncanonical	JJ
cord-296347-fanlvxqs	666	7	RING	ring	NN
cord-296347-fanlvxqs	666	8	-	-	HYPH
cord-296347-fanlvxqs	666	9	finger	finger	NN
cord-296347-fanlvxqs	666	10	domain	domain	NN
cord-296347-fanlvxqs	666	11	with	with	IN
cord-296347-fanlvxqs	666	12	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	666	13	ligase	ligase	NN
cord-296347-fanlvxqs	666	14	(	(	-LRB-
cord-296347-fanlvxqs	666	15	E3	E3	NNP
cord-296347-fanlvxqs	666	16	)	)	-RRB-
cord-296347-fanlvxqs	666	17	activity	activity	NN
cord-296347-fanlvxqs	666	18	[	[	-LRB-
cord-296347-fanlvxqs	666	19	also	also	RB
cord-296347-fanlvxqs	666	20	called	call	VBN
cord-296347-fanlvxqs	666	21	a	a	DT
cord-296347-fanlvxqs	666	22	plant	plant	NN
cord-296347-fanlvxqs	666	23	homeodomain	homeodomain	NNP
cord-296347-fanlvxqs	666	24	(	(	-LRB-
cord-296347-fanlvxqs	666	25	PHD	PHD	NNP
cord-296347-fanlvxqs	666	26	)	)	-RRB-
cord-296347-fanlvxqs	666	27	or	or	CC
cord-296347-fanlvxqs	666	28	leukemia	leukemia	NN
cord-296347-fanlvxqs	666	29	-	-	HYPH
cord-296347-fanlvxqs	666	30	associated	associate	VBN
cord-296347-fanlvxqs	666	31	protein	protein	NN
cord-296347-fanlvxqs	666	32	(	(	-LRB-
cord-296347-fanlvxqs	666	33	LAP	lap	NN
cord-296347-fanlvxqs	666	34	)	)	-RRB-
cord-296347-fanlvxqs	666	35	domain	domain	NN
cord-296347-fanlvxqs	666	36	]	]	-RRB-
cord-296347-fanlvxqs	666	37	,	,	,
cord-296347-fanlvxqs	666	38	and	and	CC
cord-296347-fanlvxqs	666	39	a	a	DT
cord-296347-fanlvxqs	666	40	conserved	conserved	JJ
cord-296347-fanlvxqs	666	41	integral	integral	JJ
cord-296347-fanlvxqs	666	42	membrane	membrane	NN
cord-296347-fanlvxqs	666	43	topology	topology	NN
cord-296347-fanlvxqs	666	44	,	,	,
cord-296347-fanlvxqs	666	45	with	with	IN
cord-296347-fanlvxqs	666	46	the	the	DT
cord-296347-fanlvxqs	666	47	transmembrane	transmembrane	NN
cord-296347-fanlvxqs	666	48	domains	domain	NNS
cord-296347-fanlvxqs	666	49	and	and	CC
cord-296347-fanlvxqs	666	50	cytosolic	cytosolic	JJ
cord-296347-fanlvxqs	666	51	C	c	NN
cord-296347-fanlvxqs	666	52	-	-	HYPH
cord-296347-fanlvxqs	666	53	terminal	terminal	NN
cord-296347-fanlvxqs	666	54	tails	tail	NNS
cord-296347-fanlvxqs	666	55	mediating	mediate	VBG
cord-296347-fanlvxqs	666	56	interaction	interaction	NN
cord-296347-fanlvxqs	666	57	with	with	IN
cord-296347-fanlvxqs	666	58	the	the	DT
cord-296347-fanlvxqs	666	59	substrate	substrate	NN
cord-296347-fanlvxqs	666	60	(	(	-LRB-
cord-296347-fanlvxqs	666	61	Coscoy	Coscoy	NNP
cord-296347-fanlvxqs	666	62	and	and	CC
cord-296347-fanlvxqs	666	63	Ganem	Ganem	NNP
cord-296347-fanlvxqs	666	64	,	,	,
cord-296347-fanlvxqs	666	65	2003	2003	CD
cord-296347-fanlvxqs	666	66	)	)	-RRB-
cord-296347-fanlvxqs	666	67	.	.	.
cord-296347-fanlvxqs	667	1	The	the	DT
cord-296347-fanlvxqs	667	2	mK3	mK3	NNP
cord-296347-fanlvxqs	667	3	PHD	PHD	NNP
cord-296347-fanlvxqs	667	4	/	/	SYM
cord-296347-fanlvxqs	667	5	LAP	lap	NN
cord-296347-fanlvxqs	667	6	-	-	HYPH
cord-296347-fanlvxqs	667	7	family	family	NN
cord-296347-fanlvxqs	667	8	E3	e3	NN
cord-296347-fanlvxqs	667	9	is	be	VBZ
cord-296347-fanlvxqs	667	10	a	a	DT
cord-296347-fanlvxqs	667	11	type	type	NN
cord-296347-fanlvxqs	667	12	III	iii	CD
cord-296347-fanlvxqs	667	13	ER	er	NN
cord-296347-fanlvxqs	667	14	membrane	membrane	NN
cord-296347-fanlvxqs	667	15	protein	protein	NN
cord-296347-fanlvxqs	667	16	with	with	IN
cord-296347-fanlvxqs	667	17	the	the	DT
cord-296347-fanlvxqs	667	18	PHD	PHD	NNP
cord-296347-fanlvxqs	667	19	/	/	SYM
cord-296347-fanlvxqs	667	20	LAP	LAP	NNP
cord-296347-fanlvxqs	667	21	RING	ring	NN
cord-296347-fanlvxqs	667	22	-	-	HYPH
cord-296347-fanlvxqs	667	23	related	relate	VBN
cord-296347-fanlvxqs	667	24	domain	domain	NN
cord-296347-fanlvxqs	667	25	facing	face	VBG
cord-296347-fanlvxqs	667	26	the	the	DT
cord-296347-fanlvxqs	667	27	cytosol	cytosol	NN
cord-296347-fanlvxqs	667	28	(	(	-LRB-
cord-296347-fanlvxqs	667	29	Boname	Boname	NNP
cord-296347-fanlvxqs	667	30	and	and	CC
cord-296347-fanlvxqs	667	31	Stevenson	Stevenson	NNP
cord-296347-fanlvxqs	667	32	,	,	,
cord-296347-fanlvxqs	667	33	2001	2001	CD
cord-296347-fanlvxqs	667	34	;	;	:
cord-296347-fanlvxqs	667	35	Sanchez	Sanchez	NNP
cord-296347-fanlvxqs	667	36	et	et	NNP
cord-296347-fanlvxqs	667	37	al	al	NNP
cord-296347-fanlvxqs	667	38	.	.	NNP
cord-296347-fanlvxqs	667	39	,	,	,
cord-296347-fanlvxqs	667	40	2002	2002	CD
cord-296347-fanlvxqs	667	41	)	)	-RRB-
cord-296347-fanlvxqs	667	42	.	.	.
cord-296347-fanlvxqs	668	1	mK3-mediated	mk3-mediated	JJ
cord-296347-fanlvxqs	668	2	degradation	degradation	NN
cord-296347-fanlvxqs	668	3	of	of	IN
cord-296347-fanlvxqs	668	4	murine	murine	JJ
cord-296347-fanlvxqs	668	5	HCs	hc	NNS
cord-296347-fanlvxqs	668	6	is	be	VBZ
cord-296347-fanlvxqs	668	7	absolutely	absolutely	RB
cord-296347-fanlvxqs	668	8	dependent	dependent	JJ
cord-296347-fanlvxqs	668	9	on	on	IN
cord-296347-fanlvxqs	668	10	components	component	NNS
cord-296347-fanlvxqs	668	11	of	of	IN
cord-296347-fanlvxqs	668	12	the	the	DT
cord-296347-fanlvxqs	668	13	PLC	PLC	NNP
cord-296347-fanlvxqs	668	14	:	:	:
cord-296347-fanlvxqs	668	15	association	association	NNP
cord-296347-fanlvxqs	668	16	of	of	IN
cord-296347-fanlvxqs	668	17	mK3	mK3	NNP
cord-296347-fanlvxqs	668	18	with	with	IN
cord-296347-fanlvxqs	668	19	TAP	TAP	NNP
cord-296347-fanlvxqs	668	20	and	and	CC
cord-296347-fanlvxqs	668	21	tapasin	tapasin	NNP
cord-296347-fanlvxqs	668	22	presumably	presumably	RB
cord-296347-fanlvxqs	668	23	imposes	impose	VBZ
cord-296347-fanlvxqs	668	24	the	the	DT
cord-296347-fanlvxqs	668	25	necessary	necessary	JJ
cord-296347-fanlvxqs	668	26	proximity	proximity	NN
cord-296347-fanlvxqs	668	27	and/or	and/or	CC
cord-296347-fanlvxqs	668	28	orientation	orientation	NN
cord-296347-fanlvxqs	668	29	of	of	IN
cord-296347-fanlvxqs	668	30	the	the	DT
cord-296347-fanlvxqs	668	31	mK3	mK3	NNP
cord-296347-fanlvxqs	668	32	RING	RING	NNP
cord-296347-fanlvxqs	668	33	domain	domain	NN
cord-296347-fanlvxqs	668	34	that	that	WDT
cord-296347-fanlvxqs	668	35	allows	allow	VBZ
cord-296347-fanlvxqs	668	36	mK3	mk3	NN
cord-296347-fanlvxqs	668	37	to	to	TO
cord-296347-fanlvxqs	668	38	specifically	specifically	RB
cord-296347-fanlvxqs	668	39	ubiquitinate	ubiquitinate	JJ
cord-296347-fanlvxqs	668	40	class	class	NN
cord-296347-fanlvxqs	668	41	I	-PRON-	PRP
cord-296347-fanlvxqs	668	42	MHC	MHC	NNP
cord-296347-fanlvxqs	668	43	HC	HC	NNP
cord-296347-fanlvxqs	668	44	as	as	IN
cord-296347-fanlvxqs	668	45	they	-PRON-	PRP
cord-296347-fanlvxqs	668	46	enter	enter	VBP
cord-296347-fanlvxqs	668	47	the	the	DT
cord-296347-fanlvxqs	668	48	PLC	PLC	NNP
cord-296347-fanlvxqs	668	49	Wang	Wang	NNP
cord-296347-fanlvxqs	668	50	et	et	NNP
cord-296347-fanlvxqs	668	51	al	al	NNP
cord-296347-fanlvxqs	668	52	.	.	.
cord-296347-fanlvxqs	669	1	,	,	,
cord-296347-fanlvxqs	669	2	2004	2004	CD
cord-296347-fanlvxqs	670	1	Wang	Wang	NNP
cord-296347-fanlvxqs	670	2	et	et	NNP
cord-296347-fanlvxqs	670	3	al	al	NNP
cord-296347-fanlvxqs	670	4	.	.	.
cord-296347-fanlvxqs	671	1	,	,	,
cord-296347-fanlvxqs	671	2	,	,	,
cord-296347-fanlvxqs	671	3	2005	2005	CD
cord-296347-fanlvxqs	671	4	.	.	.
cord-296347-fanlvxqs	672	1	mK3-mediated	mk3-mediated	JJ
cord-296347-fanlvxqs	672	2	dislocation	dislocation	NN
cord-296347-fanlvxqs	672	3	of	of	IN
cord-296347-fanlvxqs	672	4	murine	murine	JJ
cord-296347-fanlvxqs	672	5	HCs	hc	NNS
cord-296347-fanlvxqs	672	6	is	be	VBZ
cord-296347-fanlvxqs	672	7	dependent	dependent	JJ
cord-296347-fanlvxqs	672	8	on	on	IN
cord-296347-fanlvxqs	672	9	the	the	DT
cord-296347-fanlvxqs	672	10	ATPase	ATPase	NNP
cord-296347-fanlvxqs	672	11	activity	activity	NN
cord-296347-fanlvxqs	672	12	of	of	IN
cord-296347-fanlvxqs	672	13	p97	p97	CD
cord-296347-fanlvxqs	672	14	and	and	CC
cord-296347-fanlvxqs	672	15	physical	physical	JJ
cord-296347-fanlvxqs	672	16	association	association	NN
cord-296347-fanlvxqs	672	17	with	with	IN
cord-296347-fanlvxqs	672	18	Derlin-1	Derlin-1	NNP
cord-296347-fanlvxqs	672	19	and	and	CC
cord-296347-fanlvxqs	672	20	VIMP	VIMP	NNP
cord-296347-fanlvxqs	673	1	(	(	-LRB-
cord-296347-fanlvxqs	673	2	Wang	Wang	NNP
cord-296347-fanlvxqs	673	3	et	et	NNP
cord-296347-fanlvxqs	673	4	al	al	NNP
cord-296347-fanlvxqs	673	5	.	.	NNP
cord-296347-fanlvxqs	673	6	,	,	,
cord-296347-fanlvxqs	673	7	2006	2006	CD
cord-296347-fanlvxqs	673	8	d	d	NN
cord-296347-fanlvxqs	673	9	)	)	-RRB-
cord-296347-fanlvxqs	673	10	.	.	.
cord-296347-fanlvxqs	674	1	Thi	Thi	NNP
cord-296347-fanlvxqs	674	2	s	s	NNP
cord-296347-fanlvxqs	674	3	is	be	VBZ
cord-296347-fanlvxqs	674	4	reminiscen	reminiscen	NNP
cord-296347-fanlvxqs	674	5	t	t	NNP
cord-296347-fanlvxqs	674	6	of	of	IN
cord-296347-fanlvxqs	674	7	the	the	DT
cord-296347-fanlvxqs	674	8	pathway	pathway	NN
cord-296347-fanlvxqs	674	9	that	that	WDT
cord-296347-fanlvxqs	674	10	H	H	NNP
cord-296347-fanlvxqs	674	11	CMV	CMV	NNP
cord-296347-fanlvxqs	674	12	US11	US11	NNP
cord-296347-fanlvxqs	674	13	is	be	VBZ
cord-296347-fanlvxqs	674	14	propos	propos	NNP
cord-296347-fanlvxqs	674	15	ed	ed	NN
cord-296347-fanlvxqs	675	1	to	to	TO
cord-296347-fanlvxqs	675	2	co	co	VB
cord-296347-fanlvxqs	675	3	-	-	VB
cord-296347-fanlvxqs	675	4	opt	opt	VB
cord-296347-fanlvxqs	676	1	for	for	IN
cord-296347-fanlvxqs	676	2	dislocation	dislocation	NN
cord-296347-fanlvxqs	676	3	of	of	IN
cord-296347-fanlvxqs	676	4	mammalian	mammalian	JJ
cord-296347-fanlvxqs	676	5	class	class	NN
cord-296347-fanlvxqs	676	6	I	-PRON-	PRP
cord-296347-fanlvxqs	676	7	MHC	MHC	NNP
cord-296347-fanlvxqs	676	8	molecules	molecule	NNS
cord-296347-fanlvxqs	676	9	.	.	.
cord-296347-fanlvxqs	677	1	In	in	IN
cord-296347-fanlvxqs	677	2	a	a	DT
cord-296347-fanlvxqs	677	3	sense	sense	NN
cord-296347-fanlvxqs	677	4	,	,	,
cord-296347-fanlvxqs	677	5	it	-PRON-	PRP
cord-296347-fanlvxqs	677	6	appears	appear	VBZ
cord-296347-fanlvxqs	677	7	that	that	IN
cord-296347-fanlvxqs	677	8	mK3	mK3	NNP
cord-296347-fanlvxqs	677	9	may	may	MD
cord-296347-fanlvxqs	677	10	be	be	VB
cord-296347-fanlvxqs	677	11	a	a	DT
cord-296347-fanlvxqs	677	12	more	more	RBR
cord-296347-fanlvxqs	677	13	evolved	evolved	JJ
cord-296347-fanlvxqs	677	14	immunoevasin	immunoevasin	NNS
cord-296347-fanlvxqs	677	15	that	that	WDT
cord-296347-fanlvxqs	677	16	can	can	MD
cord-296347-fanlvxqs	677	17	couple	couple	VB
cord-296347-fanlvxqs	677	18	the	the	DT
cord-296347-fanlvxqs	677	19	ability	ability	NN
cord-296347-fanlvxqs	677	20	to	to	TO
cord-296347-fanlvxqs	677	21	recruit	recruit	VB
cord-296347-fanlvxqs	677	22	other	other	JJ
cord-296347-fanlvxqs	677	23	components	component	NNS
cord-296347-fanlvxqs	677	24	of	of	IN
cord-296347-fanlvxqs	677	25	the	the	DT
cord-296347-fanlvxqs	677	26	dislocation	dislocation	NN
cord-296347-fanlvxqs	677	27	machinery	machinery	NN
cord-296347-fanlvxqs	677	28	,	,	,
cord-296347-fanlvxqs	677	29	like	like	IN
cord-296347-fanlvxqs	677	30	US11	US11	NNP
cord-296347-fanlvxqs	677	31	and	and	CC
cord-296347-fanlvxqs	677	32	presumably	presumably	RB
cord-296347-fanlvxqs	677	33	US2	US2	NNP
cord-296347-fanlvxqs	677	34	,	,	,
cord-296347-fanlvxqs	677	35	with	with	IN
cord-296347-fanlvxqs	677	36	E3	e3	NN
cord-296347-fanlvxqs	677	37	ligase	ligase	NN
cord-296347-fanlvxqs	677	38	activity	activity	NN
cord-296347-fanlvxqs	677	39	,	,	,
cord-296347-fanlvxqs	677	40	in	in	IN
cord-296347-fanlvxqs	677	41	one	one	CD
cord-296347-fanlvxqs	677	42	viral	viral	JJ
cord-296347-fanlvxqs	677	43	polypeptide	polypeptide	NN
cord-296347-fanlvxqs	677	44	.	.	.
cord-296347-fanlvxqs	678	1	There	there	EX
cord-296347-fanlvxqs	678	2	are	be	VBP
cord-296347-fanlvxqs	678	3	several	several	JJ
cord-296347-fanlvxqs	678	4	mammalian	mammalian	JJ
cord-296347-fanlvxqs	678	5	K3	K3	NNP
cord-296347-fanlvxqs	678	6	homologues	homologue	NNS
cord-296347-fanlvxqs	678	7	,	,	,
cord-296347-fanlvxqs	678	8	the	the	DT
cord-296347-fanlvxqs	678	9	membrane	membrane	NN
cord-296347-fanlvxqs	678	10	-	-	HYPH
cord-296347-fanlvxqs	678	11	anchored	anchor	VBN
cord-296347-fanlvxqs	678	12	RING	ring	NN
cord-296347-fanlvxqs	678	13	-	-	HYPH
cord-296347-fanlvxqs	678	14	CH	CH	NNP
cord-296347-fanlvxqs	678	15	(	(	-LRB-
cord-296347-fanlvxqs	678	16	MARCH	MARCH	NNP
cord-296347-fanlvxqs	678	17	)	)	-RRB-
cord-296347-fanlvxqs	678	18	proteins	protein	NNS
cord-296347-fanlvxqs	678	19	(	(	-LRB-
cord-296347-fanlvxqs	678	20	Bartee	Bartee	NNP
cord-296347-fanlvxqs	678	21	et	et	NNP
cord-296347-fanlvxqs	678	22	al	al	NNP
cord-296347-fanlvxqs	678	23	.	.	NNP
cord-296347-fanlvxqs	678	24	,	,	,
cord-296347-fanlvxqs	678	25	2004	2004	CD
cord-296347-fanlvxqs	678	26	;	;	:
cord-296347-fanlvxqs	679	1	Goto	goto	VB
cord-296347-fanlvxqs	679	2	et	et	FW
cord-296347-fanlvxqs	679	3	al	al	NNP
cord-296347-fanlvxqs	679	4	.	.	NNP
cord-296347-fanlvxqs	679	5	,	,	,
cord-296347-fanlvxqs	679	6	2003	2003	CD
cord-296347-fanlvxqs	679	7	)	)	-RRB-
cord-296347-fanlvxqs	679	8	,	,	,
cord-296347-fanlvxqs	679	9	which	which	WDT
cord-296347-fanlvxqs	679	10	are	be	VBP
cord-296347-fanlvxqs	679	11	likely	likely	JJ
cord-296347-fanlvxqs	679	12	to	to	TO
cord-296347-fanlvxqs	679	13	be	be	VB
cord-296347-fanlvxqs	679	14	the	the	DT
cord-296347-fanlvxqs	679	15	cellular	cellular	JJ
cord-296347-fanlvxqs	679	16	ancestors	ancestor	NNS
cord-296347-fanlvxqs	679	17	of	of	IN
cord-296347-fanlvxqs	679	18	MHV-68	MHV-68	NNP
cord-296347-fanlvxqs	679	19	mK3	mK3	NNP
cord-296347-fanlvxqs	679	20	.	.	.
cord-296347-fanlvxqs	680	1	mK3-mediated	mk3-mediated	JJ
cord-296347-fanlvxqs	680	2	ubiquitination	ubiquitination	NN
cord-296347-fanlvxqs	680	3	of	of	IN
cord-296347-fanlvxqs	680	4	the	the	DT
cord-296347-fanlvxqs	680	5	murine	murine	JJ
cord-296347-fanlvxqs	680	6	class	class	NN
cord-296347-fanlvxqs	680	7	I	-PRON-	PRP
cord-296347-fanlvxqs	680	8	MHC	MHC	NNP
cord-296347-fanlvxqs	680	9	HC	HC	NNP
cord-296347-fanlvxqs	680	10	cytosolic	cytosolic	JJ
cord-296347-fanlvxqs	680	11	tail	tail	NN
cord-296347-fanlvxqs	680	12	,	,	,
cord-296347-fanlvxqs	680	13	the	the	DT
cord-296347-fanlvxqs	680	14	portion	portion	NN
cord-296347-fanlvxqs	680	15	of	of	IN
cord-296347-fanlvxqs	680	16	the	the	DT
cord-296347-fanlvxqs	680	17	HC	HC	NNP
cord-296347-fanlvxqs	680	18	molecule	molecule	NN
cord-296347-fanlvxqs	680	19	more	more	RBR
cord-296347-fanlvxqs	680	20	likely	likely	JJ
cord-296347-fanlvxqs	680	21	to	to	TO
cord-296347-fanlvxqs	680	22	come	come	VB
cord-296347-fanlvxqs	680	23	into	into	IN
cord-296347-fanlvxqs	680	24	contact	contact	NN
cord-296347-fanlvxqs	680	25	with	with	IN
cord-296347-fanlvxqs	680	26	the	the	DT
cord-296347-fanlvxqs	680	27	cytosolic	cytosolic	JJ
cord-296347-fanlvxqs	680	28	RING	ring	NN
cord-296347-fanlvxqs	680	29	-	-	HYPH
cord-296347-fanlvxqs	680	30	CH	ch	NN
cord-296347-fanlvxqs	680	31	domain	domain	NN
cord-296347-fanlvxqs	680	32	of	of	IN
cord-296347-fanlvxqs	680	33	mK3	mK3	NNP
cord-296347-fanlvxqs	680	34	,	,	,
cord-296347-fanlvxqs	680	35	is	be	VBZ
cord-296347-fanlvxqs	680	36	not	not	RB
cord-296347-fanlvxqs	680	37	required	require	VBN
cord-296347-fanlvxqs	680	38	for	for	IN
cord-296347-fanlvxqs	680	39	dislocation	dislocation	NN
cord-296347-fanlvxqs	680	40	even	even	RB
cord-296347-fanlvxqs	680	41	though	though	IN
cord-296347-fanlvxqs	680	42	ubiquitination	ubiquitination	NN
cord-296347-fanlvxqs	680	43	and	and	CC
cord-296347-fanlvxqs	680	44	presence	presence	NN
cord-296347-fanlvxqs	680	45	of	of	IN
cord-296347-fanlvxqs	680	46	the	the	DT
cord-296347-fanlvxqs	680	47	cytosolic	cytosolic	JJ
cord-296347-fanlvxqs	680	48	tail	tail	NN
cord-296347-fanlvxqs	680	49	are	be	VBP
cord-296347-fanlvxqs	680	50	essential	essential	JJ
cord-296347-fanlvxqs	680	51	for	for	IN
cord-296347-fanlvxqs	680	52	dislocation	dislocation	NN
cord-296347-fanlvxqs	680	53	.	.	.
cord-296347-fanlvxqs	681	1	In	in	IN
cord-296347-fanlvxqs	681	2	fact	fact	NN
cord-296347-fanlvxqs	681	3	,	,	,
cord-296347-fanlvxqs	681	4	like	like	IN
cord-296347-fanlvxqs	681	5	mK3	mK3	NNP
cord-296347-fanlvxqs	681	6	,	,	,
cord-296347-fanlvxqs	681	7	HCMV	HCMV	NNP
cord-296347-fanlvxqs	681	8	US2	US2	NNP
cord-296347-fanlvxqs	681	9	and	and	CC
cord-296347-fanlvxqs	681	10	US11	US11	NNP
cord-296347-fanlvxqs	681	11	also	also	RB
cord-296347-fanlvxqs	681	12	induce	induce	VBP
cord-296347-fanlvxqs	681	13	ubiquitination	ubiquitination	NN
cord-296347-fanlvxqs	681	14	-	-	HYPH
cord-296347-fanlvxqs	681	15	dependent	dependent	JJ
cord-296347-fanlvxqs	681	16	degradation	degradation	NN
cord-296347-fanlvxqs	681	17	of	of	IN
cord-296347-fanlvxqs	681	18	class	class	NN
cord-296347-fanlvxqs	681	19	I	-PRON-	PRP
cord-296347-fanlvxqs	681	20	MHC	MHC	NNP
cord-296347-fanlvxqs	681	21	molecules	molecule	NNS
cord-296347-fanlvxqs	681	22	in	in	IN
cord-296347-fanlvxqs	681	23	a	a	DT
cord-296347-fanlvxqs	681	24	cytosolic	cytosolic	JJ
cord-296347-fanlvxqs	681	25	tail	tail	NN
cord-296347-fanlvxqs	681	26	lysine	lysine	NN
cord-296347-fanlvxqs	681	27	-	-	HYPH
cord-296347-fanlvxqs	681	28	independent	independent	JJ
cord-296347-fanlvxqs	681	29	fashion	fashion	NN
cord-296347-fanlvxqs	681	30	(	(	-LRB-
cord-296347-fanlvxqs	681	31	Furman	Furman	NNP
cord-296347-fanlvxqs	681	32	et	et	NNP
cord-296347-fanlvxqs	681	33	al	al	NNP
cord-296347-fanlvxqs	681	34	.	.	NNP
cord-296347-fanlvxqs	681	35	,	,	,
cord-296347-fanlvxqs	681	36	2003	2003	CD
cord-296347-fanlvxqs	681	37	;	;	:
cord-296347-fanlvxqs	682	1	Shamu	Shamu	NNP
cord-296347-fanlvxqs	682	2	et	et	NNP
cord-296347-fanlvxqs	682	3	al	al	NNP
cord-296347-fanlvxqs	682	4	.	.	NNP
cord-296347-fanlvxqs	682	5	,	,	,
cord-296347-fanlvxqs	682	6	1999	1999	CD
cord-296347-fanlvxqs	682	7	)	)	-RRB-
cord-296347-fanlvxqs	682	8	.	.	.
cord-296347-fanlvxqs	683	1	How	how	WRB
cord-296347-fanlvxqs	683	2	,	,	,
cord-296347-fanlvxqs	683	3	then	then	RB
cord-296347-fanlvxqs	683	4	,	,	,
cord-296347-fanlvxqs	683	5	does	do	VBZ
cord-296347-fanlvxqs	683	6	mK3	mK3	NNP
cord-296347-fanlvxqs	683	7	access	access	VB
cord-296347-fanlvxqs	683	8	the	the	DT
cord-296347-fanlvxqs	683	9	luminal	luminal	JJ
cord-296347-fanlvxqs	683	10	domain	domain	NN
cord-296347-fanlvxqs	683	11	of	of	IN
cord-296347-fanlvxqs	683	12	HC	HC	NNP
cord-296347-fanlvxqs	683	13	molecules	molecule	NNS
cord-296347-fanlvxqs	683	14	and	and	CC
cord-296347-fanlvxqs	683	15	trigger	trigger	VB
cord-296347-fanlvxqs	683	16	its	-PRON-	PRP$
cord-296347-fanlvxqs	683	17	ubiquitination	ubiquitination	NN
cord-296347-fanlvxqs	683	18	?	?	.
cord-296347-fanlvxqs	684	1	Access	access	NN
cord-296347-fanlvxqs	684	2	of	of	IN
cord-296347-fanlvxqs	684	3	the	the	DT
cord-296347-fanlvxqs	684	4	HC	HC	NNP
cord-296347-fanlvxqs	684	5	lumenal	lumenal	JJ
cord-296347-fanlvxqs	684	6	domain	domain	NN
cord-296347-fanlvxqs	684	7	to	to	IN
cord-296347-fanlvxqs	684	8	the	the	DT
cord-296347-fanlvxqs	684	9	cytosol	cytosol	NN
cord-296347-fanlvxqs	684	10	would	would	MD
cord-296347-fanlvxqs	684	11	invoke	invoke	VB
cord-296347-fanlvxqs	684	12	a	a	DT
cord-296347-fanlvxqs	684	13	'	'	''
cord-296347-fanlvxqs	684	14	'	'	``
cord-296347-fanlvxqs	684	15	partial	partial	JJ
cord-296347-fanlvxqs	684	16	dislocation	dislocation	NN
cord-296347-fanlvxqs	684	17	'	'	''
cord-296347-fanlvxqs	684	18	'	'	''
cord-296347-fanlvxqs	684	19	model	model	NN
cord-296347-fanlvxqs	684	20	that	that	WDT
cord-296347-fanlvxqs	684	21	has	have	VBZ
cord-296347-fanlvxqs	684	22	been	be	VBN
cord-296347-fanlvxqs	684	23	proposed	propose	VBN
cord-296347-fanlvxqs	684	24	for	for	IN
cord-296347-fanlvxqs	684	25	HCMV	HCMV	NNP
cord-296347-fanlvxqs	684	26	US2	US2	NNP
cord-296347-fanlvxqs	684	27	and	and	CC
cord-296347-fanlvxqs	685	1	US11	US11	NNP
cord-296347-fanlvxqs	685	2	(	(	-LRB-
cord-296347-fanlvxqs	685	3	Furman	Furman	NNP
cord-296347-fanlvxqs	685	4	et	et	NNP
cord-296347-fanlvxqs	685	5	al	al	NNP
cord-296347-fanlvxqs	685	6	.	.	NNP
cord-296347-fanlvxqs	685	7	,	,	,
cord-296347-fanlvxqs	685	8	2003	2003	CD
cord-296347-fanlvxqs	685	9	;	;	:
cord-296347-fanlvxqs	685	10	Shamu	Shamu	NNP
cord-296347-fanlvxqs	685	11	et	et	NNP
cord-296347-fanlvxqs	685	12	al	al	NNP
cord-296347-fanlvxqs	685	13	.	.	NNP
cord-296347-fanlvxqs	685	14	,	,	,
cord-296347-fanlvxqs	685	15	1999	1999	CD
cord-296347-fanlvxqs	685	16	)	)	-RRB-
cord-296347-fanlvxqs	685	17	:	:	:
cord-296347-fanlvxqs	685	18	the	the	DT
cord-296347-fanlvxqs	685	19	HC	HC	NNP
cord-296347-fanlvxqs	685	20	luminal	luminal	JJ
cord-296347-fanlvxqs	685	21	domain	domain	NN
cord-296347-fanlvxqs	685	22	must	must	MD
cord-296347-fanlvxqs	685	23	begin	begin	VB
cord-296347-fanlvxqs	685	24	to	to	TO
cord-296347-fanlvxqs	685	25	emerge	emerge	VB
cord-296347-fanlvxqs	685	26	in	in	IN
cord-296347-fanlvxqs	685	27	the	the	DT
cord-296347-fanlvxqs	685	28	cytosolic	cytosolic	JJ
cord-296347-fanlvxqs	685	29	face	face	NN
cord-296347-fanlvxqs	685	30	of	of	IN
cord-296347-fanlvxqs	685	31	the	the	DT
cord-296347-fanlvxqs	685	32	ER	ER	NNP
cord-296347-fanlvxqs	685	33	so	so	IN
cord-296347-fanlvxqs	685	34	ubiquitination	ubiquitination	NN
cord-296347-fanlvxqs	685	35	can	can	MD
cord-296347-fanlvxqs	685	36	take	take	VB
cord-296347-fanlvxqs	685	37	place	place	NN
cord-296347-fanlvxqs	685	38	.	.	.
cord-296347-fanlvxqs	686	1	This	this	DT
cord-296347-fanlvxqs	686	2	would	would	MD
cord-296347-fanlvxqs	686	3	mean	mean	VB
cord-296347-fanlvxqs	686	4	that	that	IN
cord-296347-fanlvxqs	686	5	the	the	DT
cord-296347-fanlvxqs	686	6	trigger	trigger	NN
cord-296347-fanlvxqs	686	7	for	for	IN
cord-296347-fanlvxqs	686	8	dislocation	dislocation	NN
cord-296347-fanlvxqs	686	9	would	would	MD
cord-296347-fanlvxqs	686	10	reside	reside	VB
cord-296347-fanlvxqs	686	11	upstream	upstream	RB
cord-296347-fanlvxqs	686	12	from	from	IN
cord-296347-fanlvxqs	686	13	tail	tail	NN
cord-296347-fanlvxqs	686	14	ubiquitination	ubiquitination	NN
cord-296347-fanlvxqs	686	15	.	.	.
cord-296347-fanlvxqs	687	1	An	an	DT
cord-296347-fanlvxqs	687	2	alternative	alternative	JJ
cord-296347-fanlvxqs	687	3	explanation	explanation	NN
cord-296347-fanlvxqs	687	4	would	would	MD
cord-296347-fanlvxqs	687	5	be	be	VB
cord-296347-fanlvxqs	687	6	that	that	IN
cord-296347-fanlvxqs	687	7	the	the	DT
cord-296347-fanlvxqs	687	8	class	class	NN
cord-296347-fanlvxqs	687	9	I	-PRON-	PRP
cord-296347-fanlvxqs	687	10	MHC	MHC	NNP
cord-296347-fanlvxqs	687	11	tail	tail	NN
cord-296347-fanlvxqs	687	12	lysine	lysine	NN
cord-296347-fanlvxqs	687	13	mutant	mutant	JJ
cord-296347-fanlvxqs	687	14	HC	HC	NNP
cord-296347-fanlvxqs	687	15	molecules	molecule	NNS
cord-296347-fanlvxqs	687	16	are	be	VBP
cord-296347-fanlvxqs	687	17	dislocated	dislocate	VBN
cord-296347-fanlvxqs	687	18	as	as	IN
cord-296347-fanlvxqs	687	19	a	a	DT
cord-296347-fanlvxqs	687	20	'	'	''
cord-296347-fanlvxqs	687	21	'	'	``
cord-296347-fanlvxqs	687	22	bystander	bystander	NN
cord-296347-fanlvxqs	687	23	effect	effect	NN
cord-296347-fanlvxqs	687	24	'	'	''
cord-296347-fanlvxqs	687	25	'	'	''
cord-296347-fanlvxqs	687	26	of	of	IN
cord-296347-fanlvxqs	687	27	dislocation	dislocation	NN
cord-296347-fanlvxqs	687	28	of	of	IN
cord-296347-fanlvxqs	687	29	wild	wild	JJ
cord-296347-fanlvxqs	687	30	type	type	NN
cord-296347-fanlvxqs	687	31	molecules	molecule	NNS
cord-296347-fanlvxqs	687	32	by	by	IN
cord-296347-fanlvxqs	687	33	mK3	mK3	NNP
cord-296347-fanlvxqs	687	34	,	,	,
cord-296347-fanlvxqs	687	35	simply	simply	RB
cord-296347-fanlvxqs	687	36	because	because	IN
cord-296347-fanlvxqs	687	37	they	-PRON-	PRP
cord-296347-fanlvxqs	687	38	are	be	VBP
cord-296347-fanlvxqs	687	39	in	in	IN
cord-296347-fanlvxqs	687	40	the	the	DT
cord-296347-fanlvxqs	687	41	proximity	proximity	NN
cord-296347-fanlvxqs	687	42	of	of	IN
cord-296347-fanlvxqs	687	43	the	the	DT
cord-296347-fanlvxqs	687	44	dislocation	dislocation	NN
cord-296347-fanlvxqs	687	45	machinery	machinery	NN
cord-296347-fanlvxqs	687	46	that	that	WDT
cord-296347-fanlvxqs	687	47	has	have	VBZ
cord-296347-fanlvxqs	687	48	been	be	VBN
cord-296347-fanlvxqs	687	49	recruited	recruit	VBN
cord-296347-fanlvxqs	687	50	by	by	IN
cord-296347-fanlvxqs	687	51	the	the	DT
cord-296347-fanlvxqs	687	52	viral	viral	JJ
cord-296347-fanlvxqs	687	53	protein	protein	NN
cord-296347-fanlvxqs	687	54	for	for	IN
cord-296347-fanlvxqs	687	55	the	the	DT
cord-296347-fanlvxqs	687	56	wild	wild	JJ
cord-296347-fanlvxqs	687	57	type	type	NN
cord-296347-fanlvxqs	687	58	HC	HC	NNP
cord-296347-fanlvxqs	687	59	clientele	clientele	NNS
cord-296347-fanlvxqs	687	60	.	.	.
cord-296347-fanlvxqs	688	1	The	the	DT
cord-296347-fanlvxqs	688	2	HCMV	HCMV	NNP
cord-296347-fanlvxqs	688	3	US2	US2	NNP
cord-296347-fanlvxqs	688	4	and	and	CC
cord-296347-fanlvxqs	688	5	US11	US11	NNP
cord-296347-fanlvxqs	688	6	and	and	CC
cord-296347-fanlvxqs	688	7	MHV-68	MHV-68	NNP
cord-296347-fanlvxqs	688	8	mK3	mK3	NNP
cord-296347-fanlvxqs	688	9	immunoevasins	immunoevasin	VBZ
cord-296347-fanlvxqs	688	10	all	all	DT
cord-296347-fanlvxqs	688	11	target	target	VBP
cord-296347-fanlvxqs	688	12	nascent	nascent	JJ
cord-296347-fanlvxqs	688	13	class	class	NN
cord-296347-fanlvxqs	689	1	I	-PRON-	PRP
cord-296347-fanlvxqs	689	2	MHC	MHC	NNP
cord-296347-fanlvxqs	689	3	HCs	hc	NNS
cord-296347-fanlvxqs	689	4	for	for	IN
cord-296347-fanlvxqs	689	5	degradation	degradation	NN
cord-296347-fanlvxqs	689	6	by	by	IN
cord-296347-fanlvxqs	689	7	inducing	induce	VBG
cord-296347-fanlvxqs	689	8	their	-PRON-	PRP$
cord-296347-fanlvxqs	689	9	dislocation	dislocation	NN
cord-296347-fanlvxqs	689	10	from	from	IN
cord-296347-fanlvxqs	689	11	the	the	DT
cord-296347-fanlvxqs	689	12	ER	ER	NNP
cord-296347-fanlvxqs	689	13	membrane	membrane	NN
cord-296347-fanlvxqs	689	14	.	.	.
cord-296347-fanlvxqs	690	1	The	the	DT
cord-296347-fanlvxqs	690	2	mechanisms	mechanism	NNS
cord-296347-fanlvxqs	690	3	used	use	VBN
cord-296347-fanlvxqs	690	4	by	by	IN
cord-296347-fanlvxqs	690	5	US2	US2	NNP
cord-296347-fanlvxqs	690	6	,	,	,
cord-296347-fanlvxqs	690	7	US11	US11	NNP
cord-296347-fanlvxqs	690	8	,	,	,
cord-296347-fanlvxqs	690	9	and	and	CC
cord-296347-fanlvxqs	690	10	mK3	mK3	NNP
cord-296347-fanlvxqs	690	11	,	,	,
cord-296347-fanlvxqs	690	12	however	however	RB
cord-296347-fanlvxqs	690	13	,	,	,
cord-296347-fanlvxqs	690	14	when	when	WRB
cord-296347-fanlvxqs	690	15	analyzed	analyze	VBN
cord-296347-fanlvxqs	690	16	in	in	IN
cord-296347-fanlvxqs	690	17	detail	detail	NN
cord-296347-fanlvxqs	690	18	,	,	,
cord-296347-fanlvxqs	690	19	are	be	VBP
cord-296347-fanlvxqs	690	20	strikingly	strikingly	RB
cord-296347-fanlvxqs	690	21	different	different	JJ
cord-296347-fanlvxqs	690	22	.	.	.
cord-296347-fanlvxqs	691	1	For	for	IN
cord-296347-fanlvxqs	691	2	instance	instance	NN
cord-296347-fanlvxqs	691	3	,	,	,
cord-296347-fanlvxqs	691	4	the	the	DT
cord-296347-fanlvxqs	691	5	stage	stage	NN
cord-296347-fanlvxqs	691	6	of	of	IN
cord-296347-fanlvxqs	691	7	class	class	NN
cord-296347-fanlvxqs	691	8	I	-PRON-	PRP
cord-296347-fanlvxqs	691	9	MHC	MHC	NNP
cord-296347-fanlvxqs	691	10	HC	HC	NNP
cord-296347-fanlvxqs	691	11	biosynthesis	biosynthesis	NN
cord-296347-fanlvxqs	691	12	that	that	WDT
cord-296347-fanlvxqs	691	13	is	be	VBZ
cord-296347-fanlvxqs	691	14	targeted	target	VBN
cord-296347-fanlvxqs	691	15	by	by	IN
cord-296347-fanlvxqs	691	16	each	each	DT
cord-296347-fanlvxqs	691	17	viral	viral	JJ
cord-296347-fanlvxqs	691	18	protein	protein	NN
cord-296347-fanlvxqs	691	19	is	be	VBZ
cord-296347-fanlvxqs	691	20	distinct	distinct	JJ
cord-296347-fanlvxqs	691	21	:	:	:
cord-296347-fanlvxqs	692	1	US11	US11	NNP
cord-296347-fanlvxqs	692	2	is	be	VBZ
cord-296347-fanlvxqs	692	3	the	the	DT
cord-296347-fanlvxqs	692	4	most	most	RBS
cord-296347-fanlvxqs	692	5	promiscuous	promiscuous	JJ
cord-296347-fanlvxqs	692	6	,	,	,
cord-296347-fanlvxqs	692	7	targeting	target	VBG
cord-296347-fanlvxqs	692	8	multiple	multiple	JJ
cord-296347-fanlvxqs	692	9	class	class	NN
cord-296347-fanlvxqs	692	10	I	-PRON-	PRP
cord-296347-fanlvxqs	692	11	MHC	MHC	NNP
cord-296347-fanlvxqs	692	12	assembly	assembly	NN
cord-296347-fanlvxqs	692	13	intermediates	intermediate	NNS
cord-296347-fanlvxqs	692	14	,	,	,
cord-296347-fanlvxqs	692	15	whereas	whereas	IN
cord-296347-fanlvxqs	692	16	US2	US2	NNP
cord-296347-fanlvxqs	692	17	targets	target	VBZ
cord-296347-fanlvxqs	692	18	only	only	RB
cord-296347-fanlvxqs	692	19	properly	properly	RB
cord-296347-fanlvxqs	692	20	folded	fold	VBD
cord-296347-fanlvxqs	692	21	class	class	NN
cord-296347-fanlvxqs	692	22	I	-PRON-	PRP
cord-296347-fanlvxqs	692	23	MHC	MHC	NNP
cord-296347-fanlvxqs	692	24	complexes	complex	NNS
cord-296347-fanlvxqs	692	25	and	and	CC
cord-296347-fanlvxqs	692	26	mK3	mk3	NN
cord-296347-fanlvxqs	692	27	targets	target	NNS
cord-296347-fanlvxqs	692	28	predominantly	predominantly	RB
cord-296347-fanlvxqs	692	29	incompletely	incompletely	RB
cord-296347-fanlvxqs	692	30	assembled	assemble	VBN
cord-296347-fanlvxqs	692	31	HC	HC	NNP
cord-296347-fanlvxqs	692	32	while	while	IN
cord-296347-fanlvxqs	692	33	in	in	IN
cord-296347-fanlvxqs	692	34	association	association	NN
cord-296347-fanlvxqs	692	35	with	with	IN
cord-296347-fanlvxqs	692	36	the	the	DT
cord-296347-fanlvxqs	692	37	peptide	peptide	NN
cord-296347-fanlvxqs	692	38	-	-	HYPH
cord-296347-fanlvxqs	692	39	loading	load	VBG
cord-296347-fanlvxqs	692	40	complex	complex	NN
cord-296347-fanlvxqs	692	41	.	.	.
cord-296347-fanlvxqs	693	1	The	the	DT
cord-296347-fanlvxqs	693	2	main	main	JJ
cord-296347-fanlvxqs	693	3	difference	difference	NN
cord-296347-fanlvxqs	693	4	resides	reside	VBZ
cord-296347-fanlvxqs	693	5	in	in	IN
cord-296347-fanlvxqs	693	6	the	the	DT
cord-296347-fanlvxqs	693	7	fact	fact	NN
cord-296347-fanlvxqs	693	8	that	that	IN
cord-296347-fanlvxqs	693	9	mK3	mK3	NNP
cord-296347-fanlvxqs	693	10	encompasses	encompass	VBZ
cord-296347-fanlvxqs	693	11	ubiquitination	ubiquitination	JJ
cord-296347-fanlvxqs	693	12	activity	activity	NN
cord-296347-fanlvxqs	693	13	(	(	-LRB-
cord-296347-fanlvxqs	693	14	by	by	IN
cord-296347-fanlvxqs	693	15	means	mean	NNS
cord-296347-fanlvxqs	693	16	of	of	IN
cord-296347-fanlvxqs	693	17	its	-PRON-	PRP$
cord-296347-fanlvxqs	693	18	RING	ring	NN
cord-296347-fanlvxqs	693	19	domain	domain	NN
cord-296347-fanlvxqs	693	20	)	)	-RRB-
cord-296347-fanlvxqs	693	21	,	,	,
cord-296347-fanlvxqs	693	22	substrate	substrate	NN
cord-296347-fanlvxqs	693	23	selection	selection	NN
cord-296347-fanlvxqs	693	24	(	(	-LRB-
cord-296347-fanlvxqs	693	25	by	by	IN
cord-296347-fanlvxqs	693	26	means	mean	NNS
cord-296347-fanlvxqs	693	27	of	of	IN
cord-296347-fanlvxqs	693	28	its	-PRON-	PRP$
cord-296347-fanlvxqs	693	29	association	association	NN
cord-296347-fanlvxqs	693	30	with	with	IN
cord-296347-fanlvxqs	693	31	the	the	DT
cord-296347-fanlvxqs	693	32	peptide	peptide	NN
cord-296347-fanlvxqs	693	33	-	-	HYPH
cord-296347-fanlvxqs	693	34	loading	load	VBG
cord-296347-fanlvxqs	693	35	complex	complex	NN
cord-296347-fanlvxqs	693	36	)	)	-RRB-
cord-296347-fanlvxqs	693	37	,	,	,
cord-296347-fanlvxqs	693	38	and	and	CC
cord-296347-fanlvxqs	693	39	recruitment	recruitment	NN
cord-296347-fanlvxqs	693	40	of	of	IN
cord-296347-fanlvxqs	693	41	ER	ER	NNP
cord-296347-fanlvxqs	693	42	membrane	membrane	NN
cord-296347-fanlvxqs	693	43	and	and	CC
cord-296347-fanlvxqs	693	44	cytosolic	cytosolic	JJ
cord-296347-fanlvxqs	693	45	factors	factor	NNS
cord-296347-fanlvxqs	693	46	necessary	necessary	JJ
cord-296347-fanlvxqs	693	47	for	for	IN
cord-296347-fanlvxqs	693	48	dislocation	dislocation	NN
cord-296347-fanlvxqs	693	49	(	(	-LRB-
cord-296347-fanlvxqs	693	50	like	like	IN
cord-296347-fanlvxqs	693	51	Derlin-1	Derlin-1	NNP
cord-296347-fanlvxqs	693	52	and	and	CC
cord-296347-fanlvxqs	693	53	p97	p97	LS
cord-296347-fanlvxqs	693	54	)	)	-RRB-
cord-296347-fanlvxqs	693	55	all	all	DT
cord-296347-fanlvxqs	693	56	in	in	IN
cord-296347-fanlvxqs	693	57	one	one	CD
cord-296347-fanlvxqs	693	58	polypeptide	polypeptide	NN
cord-296347-fanlvxqs	693	59	.	.	.
cord-296347-fanlvxqs	694	1	HCMV	HCMV	NNP
cord-296347-fanlvxqs	694	2	US2	US2	NNP
cord-296347-fanlvxqs	694	3	and	and	CC
cord-296347-fanlvxqs	694	4	US11	US11	NNP
cord-296347-fanlvxqs	694	5	do	do	VBP
cord-296347-fanlvxqs	694	6	not	not	RB
cord-296347-fanlvxqs	694	7	possess	possess	VB
cord-296347-fanlvxqs	694	8	E3	E3	NNP
cord-296347-fanlvxqs	694	9	ligase	ligase	NN
cord-296347-fanlvxqs	694	10	activity	activity	NN
cord-296347-fanlvxqs	694	11	and	and	CC
cord-296347-fanlvxqs	694	12	possess	possess	VBP
cord-296347-fanlvxqs	694	13	no	no	DT
cord-296347-fanlvxqs	694	14	obvious	obvious	JJ
cord-296347-fanlvxqs	694	15	sequence	sequence	NN
cord-296347-fanlvxqs	694	16	similarity	similarity	NN
cord-296347-fanlvxqs	694	17	with	with	IN
cord-296347-fanlvxqs	694	18	known	know	VBN
cord-296347-fanlvxqs	694	19	genes	gene	NNS
cord-296347-fanlvxqs	694	20	/	/	SYM
cord-296347-fanlvxqs	694	21	proteins	protein	NNS
cord-296347-fanlvxqs	694	22	that	that	WDT
cord-296347-fanlvxqs	694	23	would	would	MD
cord-296347-fanlvxqs	694	24	hint	hint	VB
cord-296347-fanlvxqs	694	25	at	at	IN
cord-296347-fanlvxqs	694	26	their	-PRON-	PRP$
cord-296347-fanlvxqs	694	27	function	function	NN
cord-296347-fanlvxqs	694	28	.	.	.
cord-296347-fanlvxqs	695	1	However	however	RB
cord-296347-fanlvxqs	695	2	,	,	,
cord-296347-fanlvxqs	695	3	at	at	IN
cord-296347-fanlvxqs	695	4	least	least	JJS
cord-296347-fanlvxqs	695	5	US11	US11	NNP
cord-296347-fanlvxqs	695	6	,	,	,
cord-296347-fanlvxqs	695	7	and	and	CC
cord-296347-fanlvxqs	695	8	presumably	presumably	RB
cord-296347-fanlvxqs	695	9	also	also	RB
cord-296347-fanlvxqs	695	10	US2	US2	NNP
cord-296347-fanlvxqs	695	11	,	,	,
cord-296347-fanlvxqs	695	12	are	be	VBP
cord-296347-fanlvxqs	695	13	still	still	RB
cord-296347-fanlvxqs	695	14	able	able	JJ
cord-296347-fanlvxqs	695	15	to	to	TO
cord-296347-fanlvxqs	695	16	induce	induce	VB
cord-296347-fanlvxqs	695	17	assembly	assembly	NN
cord-296347-fanlvxqs	695	18	of	of	IN
cord-296347-fanlvxqs	695	19	a	a	DT
cord-296347-fanlvxqs	695	20	dislocation	dislocation	NN
cord-296347-fanlvxqs	695	21	complex	complex	NN
cord-296347-fanlvxqs	696	1	(	(	-LRB-
cord-296347-fanlvxqs	696	2	Fig	Fig	NNP
cord-296347-fanlvxqs	696	3	.	.	.
cord-296347-fanlvxqs	697	1	7	7	LS
cord-296347-fanlvxqs	697	2	)	)	-RRB-
cord-296347-fanlvxqs	697	3	that	that	WDT
cord-296347-fanlvxqs	697	4	encompasses	encompass	VBZ
cord-296347-fanlvxqs	697	5	all	all	PDT
cord-296347-fanlvxqs	697	6	the	the	DT
cord-296347-fanlvxqs	697	7	necessary	necessary	JJ
cord-296347-fanlvxqs	697	8	ERAD	ERAD	NNP
cord-296347-fanlvxqs	697	9	activities	activity	NNS
cord-296347-fanlvxqs	697	10	.	.	.
cord-296347-fanlvxqs	698	1	The	the	DT
cord-296347-fanlvxqs	698	2	knowledge	knowledge	NN
cord-296347-fanlvxqs	698	3	that	that	WDT
cord-296347-fanlvxqs	698	4	the	the	DT
cord-296347-fanlvxqs	698	5	TMD	TMD	NNP
cord-296347-fanlvxqs	698	6	of	of	IN
cord-296347-fanlvxqs	698	7	US11	US11	NNP
cord-296347-fanlvxqs	698	8	is	be	VBZ
cord-296347-fanlvxqs	698	9	essential	essential	JJ
cord-296347-fanlvxqs	698	10	for	for	IN
cord-296347-fanlvxqs	698	11	its	-PRON-	PRP$
cord-296347-fanlvxqs	698	12	function	function	NN
cord-296347-fanlvxqs	698	13	(	(	-LRB-
cord-296347-fanlvxqs	698	14	Lilley	Lilley	NNP
cord-296347-fanlvxqs	698	15	et	et	NNP
cord-296347-fanlvxqs	698	16	al	al	NNP
cord-296347-fanlvxqs	698	17	.	.	NNP
cord-296347-fanlvxqs	698	18	,	,	,
cord-296347-fanlvxqs	698	19	2003	2003	CD
cord-296347-fanlvxqs	698	20	)	)	-RRB-
cord-296347-fanlvxqs	698	21	,	,	,
cord-296347-fanlvxqs	698	22	led	lead	VBD
cord-296347-fanlvxqs	698	23	to	to	IN
cord-296347-fanlvxqs	698	24	the	the	DT
cord-296347-fanlvxqs	698	25	discovery	discovery	NN
cord-296347-fanlvxqs	698	26	of	of	IN
cord-296347-fanlvxqs	698	27	Derlins	Derlins	NNP
cord-296347-fanlvxqs	698	28	(	(	-LRB-
cord-296347-fanlvxqs	698	29	Lilley	Lilley	NNP
cord-296347-fanlvxqs	698	30	and	and	CC
cord-296347-fanlvxqs	698	31	Ploegh	Ploegh	NNP
cord-296347-fanlvxqs	698	32	,	,	,
cord-296347-fanlvxqs	698	33	2004	2004	CD
cord-296347-fanlvxqs	698	34	)	)	-RRB-
cord-296347-fanlvxqs	698	35	and	and	CC
cord-296347-fanlvxqs	698	36	of	of	IN
cord-296347-fanlvxqs	698	37	multiprotein	multiprotein	NNP
cord-296347-fanlvxqs	698	38	complexes	complex	NNS
cord-296347-fanlvxqs	698	39	at	at	IN
cord-296347-fanlvxqs	698	40	the	the	DT
cord-296347-fanlvxqs	698	41	ER	ER	NNP
cord-296347-fanlvxqs	698	42	membrane	membrane	NN
cord-296347-fanlvxqs	698	43	that	that	WDT
cord-296347-fanlvxqs	698	44	function	function	VBP
cord-296347-fanlvxqs	698	45	in	in	IN
cord-296347-fanlvxqs	698	46	US11-mediated	us11-mediated	CD
cord-296347-fanlvxqs	698	47	dislocation	dislocation	NN
cord-296347-fanlvxqs	698	48	of	of	IN
cord-296347-fanlvxqs	698	49	HCs	hc	NNS
cord-296347-fanlvxqs	698	50	and	and	CC
cord-296347-fanlvxqs	698	51	US11-independent	us11-independent	CD
cord-296347-fanlvxqs	698	52	dislocation	dislocation	NN
cord-296347-fanlvxqs	698	53	of	of	IN
cord-296347-fanlvxqs	698	54	a	a	DT
cord-296347-fanlvxqs	698	55	subset	subset	NN
cord-296347-fanlvxqs	698	56	of	of	IN
cord-296347-fanlvxqs	698	57	ERAD	ERAD	NNP
cord-296347-fanlvxqs	698	58	substrates	substrate	NNS
cord-296347-fanlvxqs	698	59	(	(	-LRB-
cord-296347-fanlvxqs	698	60	Lilley	Lilley	NNP
cord-296347-fanlvxqs	698	61	and	and	CC
cord-296347-fanlvxqs	698	62	Ploegh	Ploegh	NNP
cord-296347-fanlvxqs	698	63	,	,	,
cord-296347-fanlvxqs	698	64	2005a	2005a	CD
cord-296347-fanlvxqs	698	65	;	;	:
cord-296347-fanlvxqs	698	66	Oda	Oda	NNP
cord-296347-fanlvxqs	698	67	et	et	FW
cord-296347-fanlvxqs	698	68	al	al	NNP
cord-296347-fanlvxqs	698	69	.	.	NNP
cord-296347-fanlvxqs	698	70	,	,	,
cord-296347-fanlvxqs	698	71	2006	2006	CD
cord-296347-fanlvxqs	698	72	;	;	.
cord-296347-fanlvxqs	699	1	Ye	Ye	NNP
cord-296347-fanlvxqs	699	2	et	et	NNP
cord-296347-fanlvxqs	699	3	al	al	NNP
cord-296347-fanlvxqs	699	4	.	.	NNP
cord-296347-fanlvxqs	699	5	,	,	,
cord-296347-fanlvxqs	699	6	2005	2005	CD
cord-296347-fanlvxqs	699	7	)	)	-RRB-
cord-296347-fanlvxqs	699	8	.	.	.
cord-296347-fanlvxqs	700	1	US2	US2	NNP
cord-296347-fanlvxqs	700	2	uses	use	VBZ
cord-296347-fanlvxqs	700	3	its	-PRON-	PRP$
cord-296347-fanlvxqs	700	4	cytosolic	cytosolic	JJ
cord-296347-fanlvxqs	700	5	tail	tail	NN
cord-296347-fanlvxqs	700	6	to	to	TO
cord-296347-fanlvxqs	700	7	recruit	recruit	VB
cord-296347-fanlvxqs	700	8	SPP	SPP	NNP
cord-296347-fanlvxqs	700	9	and	and	CC
cord-296347-fanlvxqs	700	10	its	-PRON-	PRP$
cord-296347-fanlvxqs	700	11	TMD	TMD	NNP
cord-296347-fanlvxqs	700	12	for	for	IN
cord-296347-fanlvxqs	700	13	an	an	DT
cord-296347-fanlvxqs	700	14	additional	additional	JJ
cord-296347-fanlvxqs	700	15	step	step	NN
cord-296347-fanlvxqs	700	16	(	(	-LRB-
cord-296347-fanlvxqs	700	17	so	so	RB
cord-296347-fanlvxqs	700	18	far	far	RB
cord-296347-fanlvxqs	700	19	unknown	unknown	JJ
cord-296347-fanlvxqs	700	20	)	)	-RRB-
cord-296347-fanlvxqs	700	21	also	also	RB
cord-296347-fanlvxqs	700	22	critical	critical	JJ
cord-296347-fanlvxqs	700	23	for	for	IN
cord-296347-fanlvxqs	700	24	HC	HC	NNP
cord-296347-fanlvxqs	700	25	dislocation	dislocation	NN
cord-296347-fanlvxqs	700	26	(	(	-LRB-
cord-296347-fanlvxqs	700	27	Loureiro	Loureiro	NNP
cord-296347-fanlvxqs	700	28	et	et	FW
cord-296347-fanlvxqs	700	29	al	al	NNP
cord-296347-fanlvxqs	700	30	.	.	NNP
cord-296347-fanlvxqs	700	31	,	,	,
cord-296347-fanlvxqs	700	32	2006	2006	CD
cord-296347-fanlvxqs	700	33	)	)	-RRB-
cord-296347-fanlvxqs	700	34	,	,	,
cord-296347-fanlvxqs	700	35	presumably	presumably	RB
cord-296347-fanlvxqs	700	36	resulting	result	VBG
cord-296347-fanlvxqs	700	37	in	in	IN
cord-296347-fanlvxqs	700	38	recruitment	recruitment	NN
cord-296347-fanlvxqs	700	39	of	of	IN
cord-296347-fanlvxqs	700	40	US2-specific	us2-specific	JJ
cord-296347-fanlvxqs	700	41	-	-	HYPH
cord-296347-fanlvxqs	700	42	components	component	NNS
cord-296347-fanlvxqs	700	43	of	of	IN
cord-296347-fanlvxqs	700	44	the	the	DT
cord-296347-fanlvxqs	700	45	ER	ER	NNP
cord-296347-fanlvxqs	700	46	dislocation	dislocation	NN
cord-296347-fanlvxqs	700	47	machinery	machinery	NN
cord-296347-fanlvxqs	700	48	.	.	.
cord-296347-fanlvxqs	701	1	The	the	DT
cord-296347-fanlvxqs	701	2	mechanism	mechanism	NN
cord-296347-fanlvxqs	701	3	by	by	IN
cord-296347-fanlvxqs	701	4	which	which	WDT
cord-296347-fanlvxqs	701	5	US2	US2	NNP
cord-296347-fanlvxqs	701	6	operates	operate	VBZ
cord-296347-fanlvxqs	701	7	will	will	MD
cord-296347-fanlvxqs	701	8	hopefully	hopefully	RB
cord-296347-fanlvxqs	701	9	be	be	VB
cord-296347-fanlvxqs	701	10	clarified	clarify	VBN
cord-296347-fanlvxqs	701	11	as	as	IN
cord-296347-fanlvxqs	701	12	we	-PRON-	PRP
cord-296347-fanlvxqs	701	13	continue	continue	VBP
cord-296347-fanlvxqs	701	14	characterizing	characterize	VBG
cord-296347-fanlvxqs	701	15	the	the	DT
cord-296347-fanlvxqs	701	16	structural	structural	JJ
cord-296347-fanlvxqs	701	17	and	and	CC
cord-296347-fanlvxqs	701	18	host	host	NN
cord-296347-fanlvxqs	701	19	cofactor	cofactor	NN
cord-296347-fanlvxqs	701	20	requirements	requirement	NNS
cord-296347-fanlvxqs	701	21	for	for	IN
cord-296347-fanlvxqs	701	22	its	-PRON-	PRP$
cord-296347-fanlvxqs	701	23	function	function	NN
cord-296347-fanlvxqs	701	24	in	in	IN
cord-296347-fanlvxqs	701	25	dislocation	dislocation	NN
cord-296347-fanlvxqs	701	26	.	.	.
cord-296347-fanlvxqs	702	1	The	the	DT
cord-296347-fanlvxqs	702	2	mechanistic	mechanistic	JJ
cord-296347-fanlvxqs	702	3	details	detail	NNS
cord-296347-fanlvxqs	702	4	of	of	IN
cord-296347-fanlvxqs	702	5	dislocation	dislocation	NN
cord-296347-fanlvxqs	702	6	catalyzed	catalyze	VBN
cord-296347-fanlvxqs	702	7	Figure	Figure	NNP
cord-296347-fanlvxqs	702	8	7	7	CD
cord-296347-fanlvxqs	702	9	Three	three	CD
cord-296347-fanlvxqs	702	10	viral	viral	JJ
cord-296347-fanlvxqs	702	11	immunoevasins	immunoevasin	NNS
cord-296347-fanlvxqs	702	12	that	that	WDT
cord-296347-fanlvxqs	702	13	co	co	NN
cord-296347-fanlvxqs	702	14	-	-	VB
cord-296347-fanlvxqs	702	15	opt	opt	VB
cord-296347-fanlvxqs	702	16	distinct	distinct	JJ
cord-296347-fanlvxqs	702	17	ERAD	ERAD	NNP
cord-296347-fanlvxqs	702	18	pathways	pathway	NNS
cord-296347-fanlvxqs	702	19	.	.	.
cord-296347-fanlvxqs	703	1	The	the	DT
cord-296347-fanlvxqs	703	2	HCMV	HCMV	NNP
cord-296347-fanlvxqs	703	3	US11	US11	NNP
cord-296347-fanlvxqs	703	4	immunoevasin	immunoevasin	NN
cord-296347-fanlvxqs	703	5	delivers	deliver	VBZ
cord-296347-fanlvxqs	703	6	class	class	NN
cord-296347-fanlvxqs	704	1	I	-PRON-	PRP
cord-296347-fanlvxqs	704	2	MHC	MHC	NNP
cord-296347-fanlvxqs	704	3	HC	HC	NNP
cord-296347-fanlvxqs	704	4	molecules	molecule	NNS
cord-296347-fanlvxqs	704	5	to	to	IN
cord-296347-fanlvxqs	704	6	Derlins	Derlins	NNP
cord-296347-fanlvxqs	704	7	for	for	IN
cord-296347-fanlvxqs	704	8	dislocation	dislocation	NN
cord-296347-fanlvxqs	704	9	from	from	IN
cord-296347-fanlvxqs	704	10	the	the	DT
cord-296347-fanlvxqs	704	11	ER	ER	NNP
cord-296347-fanlvxqs	704	12	membrane	membrane	NN
cord-296347-fanlvxqs	704	13	and	and	CC
cord-296347-fanlvxqs	704	14	degradation	degradation	NN
cord-296347-fanlvxqs	704	15	,	,	,
cord-296347-fanlvxqs	704	16	whereas	whereas	IN
cord-296347-fanlvxqs	704	17	HCMV	HCMV	NNP
cord-296347-fanlvxqs	704	18	US2	US2	NNP
cord-296347-fanlvxqs	704	19	uses	use	VBZ
cord-296347-fanlvxqs	704	20	a	a	DT
cord-296347-fanlvxqs	704	21	pathway	pathway	NN
cord-296347-fanlvxqs	704	22	that	that	WDT
cord-296347-fanlvxqs	704	23	is	be	VBZ
cord-296347-fanlvxqs	704	24	dependent	dependent	JJ
cord-296347-fanlvxqs	704	25	on	on	IN
cord-296347-fanlvxqs	704	26	signal	signal	NN
cord-296347-fanlvxqs	704	27	peptide	peptide	NN
cord-296347-fanlvxqs	704	28	peptidase	peptidase	NN
cord-296347-fanlvxqs	704	29	.	.	.
cord-296347-fanlvxqs	705	1	The	the	DT
cord-296347-fanlvxqs	705	2	MHV-68	MHV-68	NNP
cord-296347-fanlvxqs	705	3	mK3	mK3	NNP
cord-296347-fanlvxqs	705	4	immunoevasin	immunoevasin	NNP
cord-296347-fanlvxqs	705	5	is	be	VBZ
cord-296347-fanlvxqs	705	6	an	an	DT
cord-296347-fanlvxqs	705	7	E3	e3	NN
cord-296347-fanlvxqs	705	8	ligase	ligase	NN
cord-296347-fanlvxqs	705	9	that	that	WDT
cord-296347-fanlvxqs	705	10	uses	use	VBZ
cord-296347-fanlvxqs	705	11	the	the	DT
cord-296347-fanlvxqs	705	12	PLC	PLC	NNP
cord-296347-fanlvxqs	705	13	as	as	IN
cord-296347-fanlvxqs	705	14	a	a	DT
cord-296347-fanlvxqs	705	15	platform	platform	NN
cord-296347-fanlvxqs	705	16	to	to	TO
cord-296347-fanlvxqs	705	17	target	target	VB
cord-296347-fanlvxqs	705	18	murine	murine	JJ
cord-296347-fanlvxqs	705	19	class	class	NN
cord-296347-fanlvxqs	706	1	I	-PRON-	PRP
cord-296347-fanlvxqs	706	2	MHC	MHC	NNP
cord-296347-fanlvxqs	706	3	molecules	molecule	NNS
cord-296347-fanlvxqs	706	4	for	for	IN
cord-296347-fanlvxqs	706	5	ubiquitination	ubiquitination	NN
cord-296347-fanlvxqs	706	6	and	and	CC
cord-296347-fanlvxqs	706	7	degradation	degradation	NN
cord-296347-fanlvxqs	706	8	.	.	.
cord-296347-fanlvxqs	707	1	Although	although	IN
cord-296347-fanlvxqs	707	2	the	the	DT
cord-296347-fanlvxqs	707	3	three	three	CD
cord-296347-fanlvxqs	707	4	pathways	pathway	NNS
cord-296347-fanlvxqs	707	5	are	be	VBP
cord-296347-fanlvxqs	707	6	superficially	superficially	RB
cord-296347-fanlvxqs	707	7	similar	similar	JJ
cord-296347-fanlvxqs	707	8	,	,	,
cord-296347-fanlvxqs	707	9	the	the	DT
cord-296347-fanlvxqs	707	10	substrate	substrate	NN
cord-296347-fanlvxqs	707	11	selection	selection	NN
cord-296347-fanlvxqs	707	12	and	and	CC
cord-296347-fanlvxqs	707	13	targeting	target	VBG
cord-296347-fanlvxqs	707	14	steps	step	NNS
cord-296347-fanlvxqs	707	15	at	at	IN
cord-296347-fanlvxqs	707	16	the	the	DT
cord-296347-fanlvxqs	707	17	ER	ER	NNP
cord-296347-fanlvxqs	707	18	membrane	membrane	NN
cord-296347-fanlvxqs	707	19	are	be	VBP
cord-296347-fanlvxqs	707	20	very	very	RB
cord-296347-fanlvxqs	707	21	distinct	distinct	JJ
cord-296347-fanlvxqs	707	22	.	.	.
cord-296347-fanlvxqs	708	1	Ub	Ub	NNP
cord-296347-fanlvxqs	708	2	,	,	,
cord-296347-fanlvxqs	708	3	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	708	4	;	;	:
cord-296347-fanlvxqs	708	5	E1	E1	NNP
cord-296347-fanlvxqs	708	6	,	,	,
cord-296347-fanlvxqs	708	7	Ub	Ub	NNP
cord-296347-fanlvxqs	708	8	-	-	HYPH
cord-296347-fanlvxqs	708	9	activating	activate	VBG
cord-296347-fanlvxqs	708	10	enzyme	enzyme	NN
cord-296347-fanlvxqs	708	11	;	;	:
cord-296347-fanlvxqs	708	12	E2	E2	NNP
cord-296347-fanlvxqs	708	13	,	,	,
cord-296347-fanlvxqs	708	14	Ub	Ub	NNP
cord-296347-fanlvxqs	708	15	-	-	HYPH
cord-296347-fanlvxqs	708	16	conjugating	conjugate	VBG
cord-296347-fanlvxqs	708	17	enzyme	enzyme	NN
cord-296347-fanlvxqs	708	18	;	;	:
cord-296347-fanlvxqs	708	19	E3	E3	NNP
cord-296347-fanlvxqs	708	20	,	,	,
cord-296347-fanlvxqs	708	21	Ub	Ub	NNP
cord-296347-fanlvxqs	708	22	-	-	HYPH
cord-296347-fanlvxqs	708	23	ligase	ligase	NN
cord-296347-fanlvxqs	708	24	enzyme	enzyme	NN
cord-296347-fanlvxqs	708	25	;	;	:
cord-296347-fanlvxqs	708	26	PNGase	PNGase	NNP
cord-296347-fanlvxqs	708	27	,	,	,
cord-296347-fanlvxqs	708	28	peptide	peptide	NN
cord-296347-fanlvxqs	708	29	-	-	HYPH
cord-296347-fanlvxqs	708	30	N	n	NN
cord-296347-fanlvxqs	708	31	-	-	HYPH
cord-296347-fanlvxqs	708	32	glycanase	glycanase	NN
cord-296347-fanlvxqs	708	33	;	;	:
cord-296347-fanlvxqs	708	34	SPP	SPP	NNS
cord-296347-fanlvxqs	708	35	,	,	,
cord-296347-fanlvxqs	708	36	signal	signal	NN
cord-296347-fanlvxqs	708	37	peptide	peptide	NN
cord-296347-fanlvxqs	708	38	peptidase	peptidase	NN
cord-296347-fanlvxqs	708	39	;	;	:
cord-296347-fanlvxqs	708	40	TAP	tap	NN
cord-296347-fanlvxqs	708	41	,	,	,
cord-296347-fanlvxqs	708	42	transporter	transporter	NN
cord-296347-fanlvxqs	708	43	associated	associate	VBN
cord-296347-fanlvxqs	708	44	with	with	IN
cord-296347-fanlvxqs	708	45	antigen	antigen	NN
cord-296347-fanlvxqs	708	46	presentation	presentation	NN
cord-296347-fanlvxqs	708	47	;	;	:
cord-296347-fanlvxqs	709	1	CRT	CRT	NNP
cord-296347-fanlvxqs	709	2	,	,	,
cord-296347-fanlvxqs	709	3	calreticulin	calreticulin	NNP
cord-296347-fanlvxqs	709	4	.	.	.
cord-296347-fanlvxqs	710	1	by	by	IN
cord-296347-fanlvxqs	710	2	the	the	DT
cord-296347-fanlvxqs	710	3	HCMV	HCMV	NNP
cord-296347-fanlvxqs	710	4	US2	US2	NNP
cord-296347-fanlvxqs	710	5	and	and	CC
cord-296347-fanlvxqs	710	6	US11	US11	NNP
cord-296347-fanlvxqs	710	7	and	and	CC
cord-296347-fanlvxqs	710	8	the	the	DT
cord-296347-fanlvxqs	710	9	MHV-68	MHV-68	NNP
cord-296347-fanlvxqs	710	10	mK3	mK3	NNP
cord-296347-fanlvxqs	710	11	immunoevasins	immunoevasin	NNS
cord-296347-fanlvxqs	710	12	must	must	MD
cord-296347-fanlvxqs	710	13	be	be	VB
cord-296347-fanlvxqs	710	14	quite	quite	RB
cord-296347-fanlvxqs	710	15	diverse	diverse	JJ
cord-296347-fanlvxqs	710	16	and	and	CC
cord-296347-fanlvxqs	710	17	their	-PRON-	PRP$
cord-296347-fanlvxqs	710	18	study	study	NN
cord-296347-fanlvxqs	710	19	will	will	MD
cord-296347-fanlvxqs	710	20	most	most	RBS
cord-296347-fanlvxqs	710	21	certainly	certainly	RB
cord-296347-fanlvxqs	710	22	keep	keep	VB
cord-296347-fanlvxqs	710	23	providing	provide	VBG
cord-296347-fanlvxqs	710	24	new	new	JJ
cord-296347-fanlvxqs	710	25	insights	insight	NNS
cord-296347-fanlvxqs	710	26	into	into	IN
cord-296347-fanlvxqs	710	27	ER	ER	NNP
cord-296347-fanlvxqs	710	28	dislocation	dislocation	NN
cord-296347-fanlvxqs	710	29	.	.	.
cord-296347-fanlvxqs	711	1	Furthermore	furthermore	RB
cord-296347-fanlvxqs	711	2	,	,	,
cord-296347-fanlvxqs	711	3	it	-PRON-	PRP
cord-296347-fanlvxqs	711	4	is	be	VBZ
cord-296347-fanlvxqs	711	5	nothing	nothing	NN
cord-296347-fanlvxqs	711	6	short	short	JJ
cord-296347-fanlvxqs	711	7	of	of	IN
cord-296347-fanlvxqs	711	8	remarkable	remarkable	JJ
cord-296347-fanlvxqs	711	9	how	how	WRB
cord-296347-fanlvxqs	711	10	sequence	sequence	NN
cord-296347-fanlvxqs	711	11	and	and	CC
cord-296347-fanlvxqs	711	12	structurally	structurally	RB
cord-296347-fanlvxqs	711	13	unrelated	unrelated	JJ
cord-296347-fanlvxqs	711	14	herpesvirus	herpesvirus	NN
cord-296347-fanlvxqs	711	15	proteins	protein	NNS
cord-296347-fanlvxqs	711	16	have	have	VBP
cord-296347-fanlvxqs	711	17	converged	converge	VBN
cord-296347-fanlvxqs	711	18	into	into	IN
cord-296347-fanlvxqs	711	19	(	(	-LRB-
cord-296347-fanlvxqs	711	20	although	although	IN
cord-296347-fanlvxqs	711	21	only	only	RB
cord-296347-fanlvxqs	711	22	superficially	superficially	RB
cord-296347-fanlvxqs	711	23	)	)	-RRB-
cord-296347-fanlvxqs	711	24	similar	similar	JJ
cord-296347-fanlvxqs	711	25	mechanisms	mechanism	NNS
cord-296347-fanlvxqs	711	26	to	to	TO
cord-296347-fanlvxqs	711	27	dislocate	dislocate	VB
cord-296347-fanlvxqs	711	28	newly	newly	RB
cord-296347-fanlvxqs	711	29	synthesized	synthesize	VBN
cord-296347-fanlvxqs	711	30	class	class	NN
cord-296347-fanlvxqs	711	31	I	-PRON-	PRP
cord-296347-fanlvxqs	711	32	MHC	MHC	NNP
cord-296347-fanlvxqs	711	33	molecules	molecule	NNS
cord-296347-fanlvxqs	711	34	from	from	IN
cord-296347-fanlvxqs	711	35	the	the	DT
cord-296347-fanlvxqs	711	36	ER	ER	NNP
cord-296347-fanlvxqs	711	37	membrane	membrane	NN
cord-296347-fanlvxqs	711	38	.	.	.
cord-296347-fanlvxqs	712	1	Class	Class	NNP
cord-296347-fanlvxqs	712	2	II	II	NNP
cord-296347-fanlvxqs	712	3	MHC	MHC	NNP
cord-296347-fanlvxqs	712	4	-	-	HYPH
cord-296347-fanlvxqs	712	5	restricted	restrict	VBN
cord-296347-fanlvxqs	712	6	CD4	CD4	NNP
cord-296347-fanlvxqs	712	7	þ	þ	NNP
cord-296347-fanlvxqs	712	8	T	t	NN
cord-296347-fanlvxqs	712	9	cells	cell	NNS
cord-296347-fanlvxqs	712	10	are	be	VBP
cord-296347-fanlvxqs	712	11	crucial	crucial	JJ
cord-296347-fanlvxqs	712	12	for	for	IN
cord-296347-fanlvxqs	712	13	lymphocyte	lymphocyte	NN
cord-296347-fanlvxqs	712	14	activation	activation	NN
cord-296347-fanlvxqs	712	15	,	,	,
cord-296347-fanlvxqs	712	16	antibody	antibody	NN
cord-296347-fanlvxqs	712	17	responses	response	NNS
cord-296347-fanlvxqs	712	18	,	,	,
cord-296347-fanlvxqs	712	19	and	and	CC
cord-296347-fanlvxqs	712	20	coordination	coordination	NN
cord-296347-fanlvxqs	712	21	of	of	IN
cord-296347-fanlvxqs	712	22	the	the	DT
cord-296347-fanlvxqs	712	23	immune	immune	JJ
cord-296347-fanlvxqs	712	24	response	response	NN
cord-296347-fanlvxqs	712	25	and	and	CC
cord-296347-fanlvxqs	712	26	rely	rely	VB
cord-296347-fanlvxqs	712	27	on	on	IN
cord-296347-fanlvxqs	712	28	activation	activation	NN
cord-296347-fanlvxqs	712	29	by	by	IN
cord-296347-fanlvxqs	712	30	the	the	DT
cord-296347-fanlvxqs	712	31	professional	professional	JJ
cord-296347-fanlvxqs	712	32	APCs	apc	NNS
cord-296347-fanlvxqs	712	33	.	.	.
cord-296347-fanlvxqs	713	1	Immunoevasins	Immunoevasins	NNP
cord-296347-fanlvxqs	713	2	aimed	aim	VBN
cord-296347-fanlvxqs	713	3	at	at	IN
cord-296347-fanlvxqs	713	4	interfering	interfere	VBG
cord-296347-fanlvxqs	713	5	with	with	IN
cord-296347-fanlvxqs	713	6	class	class	NN
cord-296347-fanlvxqs	713	7	II	II	NNP
cord-296347-fanlvxqs	713	8	MHC	MHC	NNP
cord-296347-fanlvxqs	713	9	antigen	antigen	NN
cord-296347-fanlvxqs	713	10	presentation	presentation	NN
cord-296347-fanlvxqs	713	11	are	be	VBP
cord-296347-fanlvxqs	713	12	not	not	RB
cord-296347-fanlvxqs	713	13	expected	expect	VBN
cord-296347-fanlvxqs	713	14	to	to	TO
cord-296347-fanlvxqs	713	15	block	block	VB
cord-296347-fanlvxqs	713	16	presentation	presentation	NN
cord-296347-fanlvxqs	713	17	of	of	IN
cord-296347-fanlvxqs	713	18	exogenous	exogenous	JJ
cord-296347-fanlvxqs	713	19	antigens	antigen	NNS
cord-296347-fanlvxqs	713	20	to	to	IN
cord-296347-fanlvxqs	713	21	CD4	CD4	NNP
cord-296347-fanlvxqs	713	22	þ	þ	NNP
cord-296347-fanlvxqs	713	23	T	t	NN
cord-296347-fanlvxqs	713	24	cells	cell	NNS
cord-296347-fanlvxqs	713	25	,	,	,
cord-296347-fanlvxqs	713	26	unless	unless	IN
cord-296347-fanlvxqs	713	27	the	the	DT
cord-296347-fanlvxqs	713	28	APC	APC	NNP
cord-296347-fanlvxqs	713	29	is	be	VBZ
cord-296347-fanlvxqs	713	30	infected	infect	VBN
cord-296347-fanlvxqs	713	31	by	by	IN
cord-296347-fanlvxqs	713	32	the	the	DT
cord-296347-fanlvxqs	713	33	virus	virus	NN
cord-296347-fanlvxqs	713	34	(	(	-LRB-
cord-296347-fanlvxqs	713	35	Yewdell	Yewdell	NNP
cord-296347-fanlvxqs	713	36	and	and	CC
cord-296347-fanlvxqs	713	37	Hill	Hill	NNP
cord-296347-fanlvxqs	713	38	,	,	,
cord-296347-fanlvxqs	713	39	2002	2002	CD
cord-296347-fanlvxqs	713	40	)	)	-RRB-
cord-296347-fanlvxqs	713	41	.	.	.
cord-296347-fanlvxqs	714	1	Class	Class	NNP
cord-296347-fanlvxqs	714	2	II	II	NNP
cord-296347-fanlvxqs	714	3	MHC	MHC	NNP
cord-296347-fanlvxqs	714	4	expression	expression	NN
cord-296347-fanlvxqs	714	5	can	can	MD
cord-296347-fanlvxqs	714	6	,	,	,
cord-296347-fanlvxqs	714	7	however	however	RB
cord-296347-fanlvxqs	714	8	,	,	,
cord-296347-fanlvxqs	714	9	be	be	VB
cord-296347-fanlvxqs	714	10	modulated	modulate	VBN
cord-296347-fanlvxqs	714	11	by	by	IN
cord-296347-fanlvxqs	714	12	IFN	IFN	NNP
cord-296347-fanlvxqs	714	13	and	and	CC
cord-296347-fanlvxqs	714	14	receptor	receptor	NN
cord-296347-fanlvxqs	714	15	signaling	signal	VBG
cord-296347-fanlvxqs	714	16	through	through	IN
cord-296347-fanlvxqs	714	17	the	the	DT
cord-296347-fanlvxqs	714	18	CIITA	CIITA	NNP
cord-296347-fanlvxqs	714	19	transcription	transcription	NN
cord-296347-fanlvxqs	714	20	factor	factor	NN
cord-296347-fanlvxqs	714	21	(	(	-LRB-
cord-296347-fanlvxqs	714	22	Boss	Boss	NNP
cord-296347-fanlvxqs	714	23	and	and	CC
cord-296347-fanlvxqs	714	24	Jensen	Jensen	NNP
cord-296347-fanlvxqs	714	25	,	,	,
cord-296347-fanlvxqs	714	26	2003	2003	CD
cord-296347-fanlvxqs	714	27	)	)	-RRB-
cord-296347-fanlvxqs	714	28	.	.	.
cord-296347-fanlvxqs	715	1	There	there	EX
cord-296347-fanlvxqs	715	2	are	be	VBP
cord-296347-fanlvxqs	715	3	relatively	relatively	RB
cord-296347-fanlvxqs	715	4	few	few	JJ
cord-296347-fanlvxqs	715	5	examples	example	NNS
cord-296347-fanlvxqs	715	6	of	of	IN
cord-296347-fanlvxqs	715	7	viruses	virus	NNS
cord-296347-fanlvxqs	715	8	and	and	CC
cord-296347-fanlvxqs	715	9	bacteria	bacteria	NNS
cord-296347-fanlvxqs	715	10	that	that	WDT
cord-296347-fanlvxqs	715	11	directly	directly	RB
cord-296347-fanlvxqs	715	12	infect	infect	VBP
cord-296347-fanlvxqs	715	13	APCs	apc	NNS
cord-296347-fanlvxqs	715	14	and	and	CC
cord-296347-fanlvxqs	715	15	affect	affect	VB
cord-296347-fanlvxqs	715	16	IFN	IFN	NNP
cord-296347-fanlvxqs	715	17	-	-	HYPH
cord-296347-fanlvxqs	715	18	induced	induce	VBN
cord-296347-fanlvxqs	715	19	class	class	NN
cord-296347-fanlvxqs	715	20	II	II	NNP
cord-296347-fanlvxqs	715	21	MHC	MHC	NNP
cord-296347-fanlvxqs	715	22	expression	expression	NN
cord-296347-fanlvxqs	715	23	or	or	CC
cord-296347-fanlvxqs	715	24	directly	directly	RB
cord-296347-fanlvxqs	715	25	interfere	interfere	VB
cord-296347-fanlvxqs	715	26	with	with	IN
cord-296347-fanlvxqs	715	27	class	class	NN
cord-296347-fanlvxqs	715	28	II	II	NNP
cord-296347-fanlvxqs	715	29	MHC	MHC	NNP
cord-296347-fanlvxqs	715	30	-	-	HYPH
cord-296347-fanlvxqs	715	31	restricted	restrict	VBN
cord-296347-fanlvxqs	715	32	antigen	antigen	NN
cord-296347-fanlvxqs	715	33	presentation	presentation	NN
cord-296347-fanlvxqs	715	34	(	(	-LRB-
cord-296347-fanlvxqs	715	35	Hmama	Hmama	NNP
cord-296347-fanlvxqs	715	36	et	et	FW
cord-296347-fanlvxqs	715	37	al	al	NNP
cord-296347-fanlvxqs	715	38	.	.	NNP
cord-296347-fanlvxqs	715	39	,	,	,
cord-296347-fanlvxqs	715	40	1998	1998	CD
cord-296347-fanlvxqs	715	41	;	;	:
cord-296347-fanlvxqs	715	42	Hussain	Hussain	NNP
cord-296347-fanlvxqs	715	43	et	et	NNP
cord-296347-fanlvxqs	715	44	al	al	NNP
cord-296347-fanlvxqs	715	45	.	.	NNP
cord-296347-fanlvxqs	715	46	,	,	,
cord-296347-fanlvxqs	715	47	1999	1999	CD
cord-296347-fanlvxqs	715	48	;	;	:
cord-296347-fanlvxqs	715	49	Miller	Miller	NNP
cord-296347-fanlvxqs	715	50	et	et	NNP
cord-296347-fanlvxqs	715	51	al	al	NNP
cord-296347-fanlvxqs	715	52	.	.	NNP
cord-296347-fanlvxqs	715	53	,	,	,
cord-296347-fanlvxqs	715	54	1998	1998	CD
cord-296347-fanlvxqs	715	55	;	;	:
cord-296347-fanlvxqs	715	56	Rinaldo	Rinaldo	NNP
cord-296347-fanlvxqs	715	57	,	,	,
cord-296347-fanlvxqs	715	58	1994	1994	CD
cord-296347-fanlvxqs	715	59	;	;	:
cord-296347-fanlvxqs	715	60	Schuller	Schuller	NNP
cord-296347-fanlvxqs	715	61	et	et	NNP
cord-296347-fanlvxqs	715	62	al	al	NNP
cord-296347-fanlvxqs	715	63	.	.	NNP
cord-296347-fanlvxqs	715	64	,	,	,
cord-296347-fanlvxqs	715	65	1998	1998	CD
cord-296347-fanlvxqs	715	66	;	;	:
cord-296347-fanlvxqs	715	67	Srisatjaluk	Srisatjaluk	NNP
cord-296347-fanlvxqs	715	68	et	et	NNP
cord-296347-fanlvxqs	715	69	al	al	NNP
cord-296347-fanlvxqs	715	70	.	.	NNP
cord-296347-fanlvxqs	715	71	,	,	,
cord-296347-fanlvxqs	715	72	2002	2002	CD
cord-296347-fanlvxqs	715	73	;	;	:
cord-296347-fanlvxqs	715	74	Zhong	Zhong	NNP
cord-296347-fanlvxqs	715	75	et	et	NNP
cord-296347-fanlvxqs	715	76	al	al	NNP
cord-296347-fanlvxqs	715	77	.	.	NNP
cord-296347-fanlvxqs	715	78	,	,	,
cord-296347-fanlvxqs	715	79	1999	1999	CD
cord-296347-fanlvxqs	715	80	)	)	-RRB-
cord-296347-fanlvxqs	715	81	.	.	.
cord-296347-fanlvxqs	716	1	It	-PRON-	PRP
cord-296347-fanlvxqs	716	2	is	be	VBZ
cord-296347-fanlvxqs	716	3	likely	likely	JJ
cord-296347-fanlvxqs	716	4	that	that	IN
cord-296347-fanlvxqs	716	5	more	more	JJR
cord-296347-fanlvxqs	716	6	examples	example	NNS
cord-296347-fanlvxqs	716	7	will	will	MD
cord-296347-fanlvxqs	716	8	be	be	VB
cord-296347-fanlvxqs	716	9	found	find	VBN
cord-296347-fanlvxqs	716	10	as	as	IN
cord-296347-fanlvxqs	716	11	this	this	DT
cord-296347-fanlvxqs	716	12	important	important	JJ
cord-296347-fanlvxqs	716	13	question	question	NN
cord-296347-fanlvxqs	716	14	is	be	VBZ
cord-296347-fanlvxqs	716	15	being	be	VBG
cord-296347-fanlvxqs	716	16	revisited	revisit	VBN
cord-296347-fanlvxqs	716	17	.	.	.
cord-296347-fanlvxqs	717	1	For	for	IN
cord-296347-fanlvxqs	717	2	viruses	virus	NNS
cord-296347-fanlvxqs	717	3	that	that	WDT
cord-296347-fanlvxqs	717	4	do	do	VBP
cord-296347-fanlvxqs	717	5	not	not	RB
cord-296347-fanlvxqs	717	6	infect	infect	VB
cord-296347-fanlvxqs	717	7	professional	professional	JJ
cord-296347-fanlvxqs	717	8	APCs	apc	NNS
cord-296347-fanlvxqs	717	9	,	,	,
cord-296347-fanlvxqs	717	10	the	the	DT
cord-296347-fanlvxqs	717	11	route	route	NN
cord-296347-fanlvxqs	717	12	to	to	IN
cord-296347-fanlvxqs	717	13	avoiding	avoid	VBG
cord-296347-fanlvxqs	717	14	helper	helper	NN
cord-296347-fanlvxqs	717	15	T	t	NN
cord-296347-fanlvxqs	717	16	cell	cell	NN
cord-296347-fanlvxqs	717	17	and	and	CC
cord-296347-fanlvxqs	717	18	antibodymediated	antibodymediated	JJ
cord-296347-fanlvxqs	717	19	responses	response	NNS
cord-296347-fanlvxqs	717	20	is	be	VBZ
cord-296347-fanlvxqs	717	21	to	to	TO
cord-296347-fanlvxqs	717	22	interfere	interfere	VB
cord-296347-fanlvxqs	717	23	with	with	IN
cord-296347-fanlvxqs	717	24	activation	activation	NN
cord-296347-fanlvxqs	717	25	of	of	IN
cord-296347-fanlvxqs	717	26	CD4	CD4	NNP
cord-296347-fanlvxqs	717	27	þ	þ	NNP
cord-296347-fanlvxqs	717	28	T	t	NN
cord-296347-fanlvxqs	717	29	cells	cell	NNS
cord-296347-fanlvxqs	717	30	by	by	IN
cord-296347-fanlvxqs	717	31	APCs	apc	NNS
cord-296347-fanlvxqs	717	32	.	.	.
cord-296347-fanlvxqs	718	1	In	in	IN
cord-296347-fanlvxqs	718	2	this	this	DT
cord-296347-fanlvxqs	718	3	section	section	NN
cord-296347-fanlvxqs	718	4	,	,	,
cord-296347-fanlvxqs	718	5	we	-PRON-	PRP
cord-296347-fanlvxqs	718	6	present	present	VBP
cord-296347-fanlvxqs	718	7	an	an	DT
cord-296347-fanlvxqs	718	8	overview	overview	NN
cord-296347-fanlvxqs	718	9	of	of	IN
cord-296347-fanlvxqs	718	10	some	some	DT
cord-296347-fanlvxqs	718	11	of	of	IN
cord-296347-fanlvxqs	718	12	the	the	DT
cord-296347-fanlvxqs	718	13	mechanisms	mechanism	NNS
cord-296347-fanlvxqs	718	14	used	use	VBN
cord-296347-fanlvxqs	718	15	mostly	mostly	RB
cord-296347-fanlvxqs	718	16	by	by	IN
cord-296347-fanlvxqs	718	17	viral	viral	JJ
cord-296347-fanlvxqs	718	18	pathogens	pathogen	NNS
cord-296347-fanlvxqs	718	19	to	to	TO
cord-296347-fanlvxqs	718	20	actively	actively	RB
cord-296347-fanlvxqs	718	21	subvert	subvert	VB
cord-296347-fanlvxqs	718	22	class	class	NN
cord-296347-fanlvxqs	718	23	II	II	NNP
cord-296347-fanlvxqs	718	24	MHC	MHC	NNP
cord-296347-fanlvxqs	718	25	antigen	antigen	NN
cord-296347-fanlvxqs	718	26	presentation	presentation	NN
cord-296347-fanlvxqs	718	27	(	(	-LRB-
cord-296347-fanlvxqs	718	28	Fig	Fig	NNP
cord-296347-fanlvxqs	718	29	.	.	.
cord-296347-fanlvxqs	718	30	8)	8)	NNP
cord-296347-fanlvxqs	718	31	.	.	.
cord-296347-fanlvxqs	719	1	The	the	DT
cord-296347-fanlvxqs	719	2	degree	degree	NN
cord-296347-fanlvxqs	719	3	to	to	TO
cord-296347-fanlvxqs	719	4	which	which	WDT
cord-296347-fanlvxqs	719	5	other	other	JJ
cord-296347-fanlvxqs	719	6	pathogens	pathogen	NNS
cord-296347-fanlvxqs	719	7	,	,	,
cord-296347-fanlvxqs	719	8	like	like	IN
cord-296347-fanlvxqs	719	9	bacteria	bacteria	NNS
cord-296347-fanlvxqs	719	10	and	and	CC
cord-296347-fanlvxqs	719	11	parasites	parasite	NNS
cord-296347-fanlvxqs	719	12	,	,	,
cord-296347-fanlvxqs	719	13	actively	actively	RB
cord-296347-fanlvxqs	719	14	interfere	interfere	VB
cord-296347-fanlvxqs	719	15	with	with	IN
cord-296347-fanlvxqs	719	16	class	class	NN
cord-296347-fanlvxqs	719	17	II	II	NNP
cord-296347-fanlvxqs	719	18	MHC	MHC	NNP
cord-296347-fanlvxqs	719	19	antigen	antigen	NN
cord-296347-fanlvxqs	719	20	presentation	presentation	NN
cord-296347-fanlvxqs	719	21	,	,	,
cord-296347-fanlvxqs	719	22	by	by	IN
cord-296347-fanlvxqs	719	23	encoding	encode	VBG
cord-296347-fanlvxqs	719	24	'	'	''
cord-296347-fanlvxqs	719	25	'	'	``
cord-296347-fanlvxqs	719	26	immunoevasins	immunoevasin	NNS
cord-296347-fanlvxqs	719	27	'	'	''
cord-296347-fanlvxqs	719	28	'	'	''
cord-296347-fanlvxqs	719	29	rather	rather	RB
cord-296347-fanlvxqs	719	30	than	than	IN
cord-296347-fanlvxqs	719	31	passively	passively	RB
cord-296347-fanlvxqs	719	32	,	,	,
cord-296347-fanlvxqs	719	33	due	due	IN
cord-296347-fanlvxqs	719	34	to	to	IN
cord-296347-fanlvxqs	719	35	their	-PRON-	PRP$
cord-296347-fanlvxqs	719	36	residence	residence	NN
cord-296347-fanlvxqs	719	37	in	in	IN
cord-296347-fanlvxqs	719	38	endocytic	endocytic	JJ
cord-296347-fanlvxqs	719	39	compartments	compartment	NNS
cord-296347-fanlvxqs	719	40	,	,	,
cord-296347-fanlvxqs	719	41	is	be	VBZ
cord-296347-fanlvxqs	719	42	difficult	difficult	JJ
cord-296347-fanlvxqs	719	43	to	to	TO
cord-296347-fanlvxqs	719	44	discern	discern	VB
cord-296347-fanlvxqs	719	45	.	.	.
cord-296347-fanlvxqs	720	1	Epstein	Epstein	NNP
cord-296347-fanlvxqs	720	2	-	-	HYPH
cord-296347-fanlvxqs	720	3	Barr	Barr	NNP
cord-296347-fanlvxqs	720	4	virus	virus	NN
cord-296347-fanlvxqs	720	5	is	be	VBZ
cord-296347-fanlvxqs	720	6	an	an	DT
cord-296347-fanlvxqs	720	7	example	example	NN
cord-296347-fanlvxqs	720	8	of	of	IN
cord-296347-fanlvxqs	720	9	a	a	DT
cord-296347-fanlvxqs	720	10	virus	virus	NN
cord-296347-fanlvxqs	720	11	that	that	WDT
cord-296347-fanlvxqs	720	12	can	can	MD
cord-296347-fanlvxqs	720	13	infect	infect	VB
cord-296347-fanlvxqs	720	14	and	and	CC
cord-296347-fanlvxqs	720	15	establish	establish	VB
cord-296347-fanlvxqs	720	16	latency	latency	NN
cord-296347-fanlvxqs	720	17	in	in	IN
cord-296347-fanlvxqs	720	18	B	b	NN
cord-296347-fanlvxqs	720	19	lymphocytes	lymphocyte	NNS
cord-296347-fanlvxqs	720	20	and	and	CC
cord-296347-fanlvxqs	720	21	is	be	VBZ
cord-296347-fanlvxqs	720	22	associated	associate	VBN
cord-296347-fanlvxqs	720	23	with	with	IN
cord-296347-fanlvxqs	720	24	a	a	DT
cord-296347-fanlvxqs	720	25	number	number	NN
cord-296347-fanlvxqs	720	26	of	of	IN
cord-296347-fanlvxqs	720	27	malignancies	malignancy	NNS
cord-296347-fanlvxqs	720	28	.	.	.
cord-296347-fanlvxqs	721	1	The	the	DT
cord-296347-fanlvxqs	721	2	product	product	NN
cord-296347-fanlvxqs	721	3	of	of	IN
cord-296347-fanlvxqs	721	4	the	the	DT
cord-296347-fanlvxqs	721	5	BZLF2	BZLF2	NNP
cord-296347-fanlvxqs	721	6	EBV	EBV	NNP
cord-296347-fanlvxqs	721	7	gene	gene	NN
cord-296347-fanlvxqs	721	8	,	,	,
cord-296347-fanlvxqs	721	9	gp42	gp42	NNP
cord-296347-fanlvxqs	721	10	,	,	,
cord-296347-fanlvxqs	721	11	is	be	VBZ
cord-296347-fanlvxqs	721	12	a	a	DT
cord-296347-fanlvxqs	721	13	bifunctional	bifunctional	JJ
cord-296347-fanlvxqs	721	14	protein	protein	NN
cord-296347-fanlvxqs	721	15	.	.	.
cord-296347-fanlvxqs	722	1	First	first	RB
cord-296347-fanlvxqs	722	2	,	,	,
cord-296347-fanlvxqs	722	3	it	-PRON-	PRP
cord-296347-fanlvxqs	722	4	functions	function	VBZ
cord-296347-fanlvxqs	722	5	as	as	IN
cord-296347-fanlvxqs	722	6	the	the	DT
cord-296347-fanlvxqs	722	7	coreceptor	coreceptor	NN
cord-296347-fanlvxqs	722	8	for	for	IN
cord-296347-fanlvxqs	722	9	viral	viral	JJ
cord-296347-fanlvxqs	722	10	entry	entry	NN
cord-296347-fanlvxqs	722	11	into	into	IN
cord-296347-fanlvxqs	722	12	B	b	NN
cord-296347-fanlvxqs	722	13	cells	cell	NNS
cord-296347-fanlvxqs	722	14	by	by	IN
cord-296347-fanlvxqs	722	15	binding	bind	VBG
cord-296347-fanlvxqs	722	16	to	to	IN
cord-296347-fanlvxqs	722	17	the	the	DT
cord-296347-fanlvxqs	722	18	HLA	HLA	NNP
cord-296347-fanlvxqs	722	19	-	-	HYPH
cord-296347-fanlvxqs	722	20	DR	DR	NNP
cord-296347-fanlvxqs	722	21	product	product	NN
cord-296347-fanlvxqs	722	22	.	.	.
cord-296347-fanlvxqs	723	1	Second	second	RB
cord-296347-fanlvxqs	723	2	,	,	,
cord-296347-fanlvxqs	723	3	gp42	gp42	NNP
cord-296347-fanlvxqs	723	4	is	be	VBZ
cord-296347-fanlvxqs	723	5	generated	generate	VBN
cord-296347-fanlvxqs	723	6	through	through	IN
cord-296347-fanlvxqs	723	7	proteolytic	proteolytic	JJ
cord-296347-fanlvxqs	723	8	cleavage	cleavage	NN
cord-296347-fanlvxqs	723	9	in	in	IN
cord-296347-fanlvxqs	723	10	the	the	DT
cord-296347-fanlvxqs	723	11	ER	er	NN
cord-296347-fanlvxqs	723	12	and	and	CC
cord-296347-fanlvxqs	723	13	matures	mature	VBZ
cord-296347-fanlvxqs	723	14	into	into	IN
cord-296347-fanlvxqs	723	15	a	a	DT
cord-296347-fanlvxqs	723	16	secreted	secrete	VBN
cord-296347-fanlvxqs	723	17	form	form	NN
cord-296347-fanlvxqs	723	18	that	that	WDT
cord-296347-fanlvxqs	723	19	binds	bind	VBZ
cord-296347-fanlvxqs	723	20	class	class	NN
cord-296347-fanlvxqs	723	21	II	II	NNP
cord-296347-fanlvxqs	723	22	MHC	MHC	NNP
cord-296347-fanlvxqs	723	23	molecules	molecule	NNS
cord-296347-fanlvxqs	723	24	at	at	IN
cord-296347-fanlvxqs	723	25	the	the	DT
cord-296347-fanlvxqs	723	26	cell	cell	NN
cord-296347-fanlvxqs	723	27	surface	surface	NN
cord-296347-fanlvxqs	723	28	.	.	.
cord-296347-fanlvxqs	724	1	gp42	gp42	NNS
cord-296347-fanlvxqs	724	2	bound	bind	VBN
cord-296347-fanlvxqs	724	3	to	to	IN
cord-296347-fanlvxqs	724	4	class	class	NN
cord-296347-fanlvxqs	724	5	II	II	NNP
cord-296347-fanlvxqs	724	6	MHC	MHC	NNP
cord-296347-fanlvxqs	724	7	molecules	molecule	NNS
cord-296347-fanlvxqs	724	8	at	at	IN
cord-296347-fanlvxqs	724	9	the	the	DT
cord-296347-fanlvxqs	724	10	cell	cell	NN
cord-296347-fanlvxqs	724	11	surface	surface	NN
cord-296347-fanlvxqs	724	12	prevents	prevent	VBZ
cord-296347-fanlvxqs	724	13	TCR-(peptide	tcr-(peptide	RB
cord-296347-fanlvxqs	724	14	-	-	HYPH
cord-296347-fanlvxqs	724	15	loaded	load	VBN
cord-296347-fanlvxqs	724	16	class	class	NN
cord-296347-fanlvxqs	724	17	II	II	NNP
cord-296347-fanlvxqs	724	18	MHC	MHC	NNP
cord-296347-fanlvxqs	724	19	)	)	-RRB-
cord-296347-fanlvxqs	724	20	interactions	interaction	NNS
cord-296347-fanlvxqs	724	21	and	and	CC
cord-296347-fanlvxqs	724	22	CD4	CD4	NNP
cord-296347-fanlvxqs	724	23	þ	þ	NNP
cord-296347-fanlvxqs	724	24	T	T	NNP
cord-296347-fanlvxqs	724	25	cell	cell	NN
cord-296347-fanlvxqs	724	26	activation	activation	NN
cord-296347-fanlvxqs	725	1	(	(	-LRB-
cord-296347-fanlvxqs	725	2	Li	Li	NNP
cord-296347-fanlvxqs	725	3	et	et	NNP
cord-296347-fanlvxqs	725	4	al	al	NNP
cord-296347-fanlvxqs	725	5	.	.	.
cord-296347-fanlvxqs	726	1	,	,	,
cord-296347-fanlvxqs	726	2	1997	1997	CD
cord-296347-fanlvxqs	726	3	;	;	:
cord-296347-fanlvxqs	726	4	Ressing	Ressing	NNP
cord-296347-fanlvxqs	726	5	et	et	FW
cord-296347-fanlvxqs	726	6	al	al	NNP
cord-296347-fanlvxqs	726	7	.	.	NNP
cord-296347-fanlvxqs	726	8	,	,	,
cord-296347-fanlvxqs	726	9	2003	2003	CD
cord-296347-fanlvxqs	727	1	Ressing	Ressing	NNP
cord-296347-fanlvxqs	727	2	et	et	FW
cord-296347-fanlvxqs	727	3	al	al	NNP
cord-296347-fanlvxqs	727	4	.	.	.
cord-296347-fanlvxqs	728	1	,	,	,
cord-296347-fanlvxqs	728	2	,	,	,
cord-296347-fanlvxqs	728	3	2005	2005	CD
cord-296347-fanlvxqs	729	1	Spriggs	Spriggs	NNP
cord-296347-fanlvxqs	729	2	et	et	NNP
cord-296347-fanlvxqs	729	3	al	al	NNP
cord-296347-fanlvxqs	729	4	.	.	NNP
cord-296347-fanlvxqs	729	5	,	,	,
cord-296347-fanlvxqs	729	6	1996	1996	CD
cord-296347-fanlvxqs	729	7	)	)	-RRB-
cord-296347-fanlvxqs	729	8	.	.	.
cord-296347-fanlvxqs	730	1	The	the	DT
cord-296347-fanlvxqs	730	2	HIV-1	HIV-1	NNP
cord-296347-fanlvxqs	730	3	Nef	Nef	NNP
cord-296347-fanlvxqs	730	4	protein	protein	NN
cord-296347-fanlvxqs	730	5	downregulates	downregulate	VBZ
cord-296347-fanlvxqs	730	6	class	class	NN
cord-296347-fanlvxqs	730	7	II	II	NNP
cord-296347-fanlvxqs	730	8	MHC	MHC	NNP
cord-296347-fanlvxqs	730	9	molecules	molecule	NNS
cord-296347-fanlvxqs	730	10	from	from	IN
cord-296347-fanlvxqs	730	11	the	the	DT
cord-296347-fanlvxqs	730	12	cell	cell	NN
cord-296347-fanlvxqs	730	13	surface	surface	NN
cord-296347-fanlvxqs	730	14	by	by	IN
cord-296347-fanlvxqs	730	15	restructuring	restructure	VBG
cord-296347-fanlvxqs	730	16	the	the	DT
cord-296347-fanlvxqs	730	17	endocytic	endocytic	JJ
cord-296347-fanlvxqs	730	18	pathway	pathway	NN
cord-296347-fanlvxqs	730	19	such	such	JJ
cord-296347-fanlvxqs	730	20	that	that	DT
cord-296347-fanlvxqs	730	21	invariant	invariant	JJ
cord-296347-fanlvxqs	730	22	chain	chain	NN
cord-296347-fanlvxqs	730	23	(	(	-LRB-
cord-296347-fanlvxqs	730	24	Ii	ii	NN
cord-296347-fanlvxqs	730	25	)	)	-RRB-
cord-296347-fanlvxqs	730	26	degradation	degradation	NN
cord-296347-fanlvxqs	730	27	is	be	VBZ
cord-296347-fanlvxqs	730	28	impaired	impaired	JJ
cord-296347-fanlvxqs	730	29	and	and	CC
cord-296347-fanlvxqs	730	30	immature	immature	JJ
cord-296347-fanlvxqs	730	31	class	class	NN
cord-296347-fanlvxqs	730	32	II	II	NNP
cord-296347-fanlvxqs	730	33	MHC	MHC	NNP
cord-296347-fanlvxqs	730	34	complexes	complex	NNS
cord-296347-fanlvxqs	730	35	(	(	-LRB-
cord-296347-fanlvxqs	730	36	abIi	abIi	NNP
cord-296347-fanlvxqs	730	37	)	)	-RRB-
cord-296347-fanlvxqs	730	38	are	be	VBP
cord-296347-fanlvxqs	730	39	granted	grant	VBN
cord-296347-fanlvxqs	730	40	increased	increase	VBN
cord-296347-fanlvxqs	730	41	access	access	NN
cord-296347-fanlvxqs	730	42	to	to	IN
cord-296347-fanlvxqs	730	43	the	the	DT
cord-296347-fanlvxqs	730	44	cell	cell	NN
cord-296347-fanlvxqs	730	45	surface	surface	NN
cord-296347-fanlvxqs	731	1	(	(	-LRB-
cord-296347-fanlvxqs	731	2	Stumptner	Stumptner	NNP
cord-296347-fanlvxqs	731	3	-	-	HYPH
cord-296347-fanlvxqs	731	4	Cuvelette	Cuvelette	NNP
cord-296347-fanlvxqs	731	5	et	et	NNP
cord-296347-fanlvxqs	731	6	al	al	NNP
cord-296347-fanlvxqs	731	7	.	.	NNP
cord-296347-fanlvxqs	731	8	,	,	,
cord-296347-fanlvxqs	731	9	2001	2001	CD
cord-296347-fanlvxqs	731	10	)	)	-RRB-
cord-296347-fanlvxqs	731	11	.	.	.
cord-296347-fanlvxqs	732	1	Nef	Nef	NNP
cord-296347-fanlvxqs	732	2	induces	induce	VBZ
cord-296347-fanlvxqs	732	3	a	a	DT
cord-296347-fanlvxqs	732	4	reduction	reduction	NN
cord-296347-fanlvxqs	732	5	of	of	IN
cord-296347-fanlvxqs	732	6	surface	surface	NN
cord-296347-fanlvxqs	732	7	levels	level	NNS
cord-296347-fanlvxqs	732	8	of	of	IN
cord-296347-fanlvxqs	732	9	peptide	peptide	NN
cord-296347-fanlvxqs	732	10	-	-	HYPH
cord-296347-fanlvxqs	732	11	loaded	loaded	JJ
cord-296347-fanlvxqs	732	12	class	class	NN
cord-296347-fanlvxqs	732	13	II	II	NNP
cord-296347-fanlvxqs	732	14	MHC	MHC	NNP
cord-296347-fanlvxqs	732	15	as	as	RB
cord-296347-fanlvxqs	732	16	well	well	RB
cord-296347-fanlvxqs	732	17	as	as	IN
cord-296347-fanlvxqs	732	18	a	a	DT
cord-296347-fanlvxqs	732	19	strong	strong	JJ
cord-296347-fanlvxqs	732	20	accumulation	accumulation	NN
cord-296347-fanlvxqs	732	21	of	of	IN
cord-296347-fanlvxqs	732	22	surface	surface	NN
cord-296347-fanlvxqs	732	23	-	-	HYPH
cord-296347-fanlvxqs	732	24	displayed	display	VBN
cord-296347-fanlvxqs	732	25	immature	immature	JJ
cord-296347-fanlvxqs	732	26	class	class	NN
cord-296347-fanlvxqs	732	27	II	II	NNP
cord-296347-fanlvxqs	732	28	MHC	MHC	NNP
cord-296347-fanlvxqs	732	29	complexes	complex	NNS
cord-296347-fanlvxqs	732	30	,	,	,
cord-296347-fanlvxqs	732	31	still	still	RB
cord-296347-fanlvxqs	732	32	containing	contain	VBG
cord-296347-fanlvxqs	732	33	(	(	-LRB-
cord-296347-fanlvxqs	732	34	and	and	CC
cord-296347-fanlvxqs	732	35	thereby	thereby	RB
cord-296347-fanlvxqs	732	36	blocked	block	VBN
cord-296347-fanlvxqs	732	37	by	by	IN
cord-296347-fanlvxqs	732	38	)	)	-RRB-
cord-296347-fanlvxqs	732	39	intact	intact	JJ
cord-296347-fanlvxqs	732	40	invariant	invariant	JJ
cord-296347-fanlvxqs	732	41	chain	chain	NN
cord-296347-fanlvxqs	732	42	(	(	-LRB-
cord-296347-fanlvxqs	732	43	Ii	Ii	NNP
cord-296347-fanlvxqs	732	44	)	)	-RRB-
cord-296347-fanlvxqs	732	45	.	.	.
cord-296347-fanlvxqs	733	1	Nef	Nef	NNP
cord-296347-fanlvxqs	733	2	expression	expression	NN
cord-296347-fanlvxqs	733	3	results	result	NNS
cord-296347-fanlvxqs	733	4	in	in	IN
cord-296347-fanlvxqs	733	5	accumulation	accumulation	NN
cord-296347-fanlvxqs	733	6	of	of	IN
cord-296347-fanlvxqs	733	7	both	both	DT
cord-296347-fanlvxqs	733	8	class	class	NN
cord-296347-fanlvxqs	733	9	II	II	NNP
cord-296347-fanlvxqs	733	10	MHC	MHC	NNP
cord-296347-fanlvxqs	733	11	and	and	CC
cord-296347-fanlvxqs	733	12	invariant	invariant	JJ
cord-296347-fanlvxqs	733	13	chain	chain	NN
cord-296347-fanlvxqs	733	14	(	(	-LRB-
cord-296347-fanlvxqs	733	15	Ii	Ii	NNP
cord-296347-fanlvxqs	733	16	)	)	-RRB-
cord-296347-fanlvxqs	733	17	in	in	IN
cord-296347-fanlvxqs	733	18	multivesicular	multivesicular	NNP
cord-296347-fanlvxqs	733	19	bodies	body	NNS
cord-296347-fanlvxqs	733	20	(	(	-LRB-
cord-296347-fanlvxqs	733	21	MVBs	MVBs	NNP
cord-296347-fanlvxqs	733	22	)	)	-RRB-
cord-296347-fanlvxqs	734	1	(	(	-LRB-
cord-296347-fanlvxqs	734	2	Stumptner	Stumptner	NNP
cord-296347-fanlvxqs	734	3	-	-	HYPH
cord-296347-fanlvxqs	734	4	Cuvelette	Cuvelette	NNP
cord-296347-fanlvxqs	734	5	et	et	NNP
cord-296347-fanlvxqs	734	6	al	al	NNP
cord-296347-fanlvxqs	734	7	.	.	NNP
cord-296347-fanlvxqs	734	8	,	,	,
cord-296347-fanlvxqs	734	9	2003	2003	CD
cord-296347-fanlvxqs	734	10	)	)	-RRB-
cord-296347-fanlvxqs	734	11	.	.	.
cord-296347-fanlvxqs	735	1	MVBs	mvb	NNS
cord-296347-fanlvxqs	735	2	are	be	VBP
cord-296347-fanlvxqs	735	3	a	a	DT
cord-296347-fanlvxqs	735	4	specialized	specialized	JJ
cord-296347-fanlvxqs	735	5	type	type	NN
cord-296347-fanlvxqs	735	6	of	of	IN
cord-296347-fanlvxqs	735	7	endosome	endosome	NN
cord-296347-fanlvxqs	735	8	that	that	WDT
cord-296347-fanlvxqs	735	9	constitutes	constitute	VBZ
cord-296347-fanlvxqs	735	10	a	a	DT
cord-296347-fanlvxqs	735	11	major	major	JJ
cord-296347-fanlvxqs	735	12	pathway	pathway	NN
cord-296347-fanlvxqs	735	13	of	of	IN
cord-296347-fanlvxqs	735	14	delivery	delivery	NN
cord-296347-fanlvxqs	735	15	of	of	IN
cord-296347-fanlvxqs	735	16	transmembrane	transmembrane	JJ
cord-296347-fanlvxqs	735	17	proteins	protein	NNS
cord-296347-fanlvxqs	735	18	for	for	IN
cord-296347-fanlvxqs	735	19	lysosomal	lysosomal	JJ
cord-296347-fanlvxqs	735	20	degradation	degradation	NN
cord-296347-fanlvxqs	735	21	.	.	.
cord-296347-fanlvxqs	736	1	Sequestering	sequester	VBG
cord-296347-fanlvxqs	736	2	in	in	IN
cord-296347-fanlvxqs	736	3	MVBs	MVBs	NNP
cord-296347-fanlvxqs	736	4	suggests	suggest	VBZ
cord-296347-fanlvxqs	736	5	a	a	DT
cord-296347-fanlvxqs	736	6	reduced	reduce	VBN
cord-296347-fanlvxqs	736	7	capacity	capacity	NN
cord-296347-fanlvxqs	736	8	of	of	IN
cord-296347-fanlvxqs	736	9	immature	immature	JJ
cord-296347-fanlvxqs	736	10	class	class	NN
cord-296347-fanlvxqs	736	11	II	II	NNP
cord-296347-fanlvxqs	736	12	MHC	MHC	NNP
cord-296347-fanlvxqs	736	13	complexes	complex	NNS
cord-296347-fanlvxqs	736	14	to	to	TO
cord-296347-fanlvxqs	736	15	reach	reach	VB
cord-296347-fanlvxqs	736	16	lysosomes	lysosome	NNS
cord-296347-fanlvxqs	736	17	,	,	,
cord-296347-fanlvxqs	736	18	either	either	CC
cord-296347-fanlvxqs	736	19	due	due	IN
cord-296347-fanlvxqs	736	20	to	to	IN
cord-296347-fanlvxqs	736	21	a	a	DT
cord-296347-fanlvxqs	736	22	defect	defect	NN
cord-296347-fanlvxqs	736	23	in	in	IN
cord-296347-fanlvxqs	736	24	class	class	NN
cord-296347-fanlvxqs	736	25	II	II	NNP
cord-296347-fanlvxqs	736	26	MHC	MHC	NNP
cord-296347-fanlvxqs	736	27	sorting	sort	VBG
cord-296347-fanlvxqs	736	28	to	to	IN
cord-296347-fanlvxqs	736	29	the	the	DT
cord-296347-fanlvxqs	736	30	lysosomes	lysosome	NNS
cord-296347-fanlvxqs	736	31	or	or	CC
cord-296347-fanlvxqs	736	32	due	due	IN
cord-296347-fanlvxqs	736	33	to	to	IN
cord-296347-fanlvxqs	736	34	slower	slow	JJR
cord-296347-fanlvxqs	736	35	internalization	internalization	NN
cord-296347-fanlvxqs	736	36	of	of	IN
cord-296347-fanlvxqs	736	37	immature	immature	JJ
cord-296347-fanlvxqs	736	38	complexes	complex	NNS
cord-296347-fanlvxqs	736	39	.	.	.
cord-296347-fanlvxqs	737	1	The	the	DT
cord-296347-fanlvxqs	737	2	mechanism	mechanism	NN
cord-296347-fanlvxqs	737	3	is	be	VBZ
cord-296347-fanlvxqs	737	4	still	still	RB
cord-296347-fanlvxqs	737	5	unclear	unclear	JJ
cord-296347-fanlvxqs	737	6	(	(	-LRB-
cord-296347-fanlvxqs	738	1	Stumptner	Stumptner	NNP
cord-296347-fanlvxqs	738	2	-	-	HYPH
cord-296347-fanlvxqs	738	3	Cuvelette	Cuvelette	NNP
cord-296347-fanlvxqs	738	4	et	et	NNP
cord-296347-fanlvxqs	738	5	al	al	NNP
cord-296347-fanlvxqs	738	6	.	.	NNP
cord-296347-fanlvxqs	738	7	,	,	,
cord-296347-fanlvxqs	738	8	2003	2003	CD
cord-296347-fanlvxqs	738	9	)	)	-RRB-
cord-296347-fanlvxqs	738	10	.	.	.
cord-296347-fanlvxqs	739	1	The	the	DT
cord-296347-fanlvxqs	739	2	HCMV	HCMV	NNP
cord-296347-fanlvxqs	739	3	US2	US2	NNP
cord-296347-fanlvxqs	739	4	immunoevasin	immunoevasin	NNP
cord-296347-fanlvxqs	739	5	was	be	VBD
cord-296347-fanlvxqs	739	6	proposed	propose	VBN
cord-296347-fanlvxqs	739	7	to	to	TO
cord-296347-fanlvxqs	739	8	downregulate	downregulate	VB
cord-296347-fanlvxqs	739	9	class	class	NN
cord-296347-fanlvxqs	739	10	II	II	NNP
cord-296347-fanlvxqs	739	11	MHC	MHC	NNP
cord-296347-fanlvxqs	739	12	from	from	IN
cord-296347-fanlvxqs	739	13	the	the	DT
cord-296347-fanlvxqs	739	14	cell	cell	NN
cord-296347-fanlvxqs	739	15	surface	surface	NN
cord-296347-fanlvxqs	739	16	,	,	,
cord-296347-fanlvxqs	739	17	presumably	presumably	RB
cord-296347-fanlvxqs	739	18	by	by	IN
cord-296347-fanlvxqs	739	19	targeting	target	VBG
cord-296347-fanlvxqs	739	20	HLA	HLA	NNP
cord-296347-fanlvxqs	739	21	-	-	HYPH
cord-296347-fanlvxqs	739	22	DRa	DRa	NNS
cord-296347-fanlvxqs	739	23	and	and	CC
cord-296347-fanlvxqs	739	24	HLA	HLA	NNP
cord-296347-fanlvxqs	739	25	-	-	HYPH
cord-296347-fanlvxqs	739	26	DMa	DMa	NNS
cord-296347-fanlvxqs	739	27	for	for	IN
cord-296347-fanlvxqs	739	28	degradation	degradation	NN
cord-296347-fanlvxqs	739	29	by	by	IN
cord-296347-fanlvxqs	739	30	the	the	DT
cord-296347-fanlvxqs	739	31	proteasome	proteasome	NN
cord-296347-fanlvxqs	739	32	,	,	,
cord-296347-fanlvxqs	739	33	thus	thus	RB
cord-296347-fanlvxqs	739	34	inhibiting	inhibit	VBG
cord-296347-fanlvxqs	739	35	antigen	antigen	NN
cord-296347-fanlvxqs	739	36	presentation	presentation	NN
cord-296347-fanlvxqs	739	37	to	to	IN
cord-296347-fanlvxqs	739	38	CD4	CD4	NNP
cord-296347-fanlvxqs	739	39	þ	þ	NNP
cord-296347-fanlvxqs	739	40	T	t	NN
cord-296347-fanlvxqs	739	41	cells	cell	NNS
cord-296347-fanlvxqs	739	42	(	(	-LRB-
cord-296347-fanlvxqs	739	43	Chevalier	Chevalier	NNP
cord-296347-fanlvxqs	739	44	et	et	NNP
cord-296347-fanlvxqs	739	45	al	al	NNP
cord-296347-fanlvxqs	739	46	.	.	NNP
cord-296347-fanlvxqs	739	47	,	,	,
cord-296347-fanlvxqs	739	48	2002	2002	CD
cord-296347-fanlvxqs	739	49	;	;	:
cord-296347-fanlvxqs	739	50	Hegde	Hegde	NNP
cord-296347-fanlvxqs	739	51	and	and	CC
cord-296347-fanlvxqs	739	52	Johnson	Johnson	NNP
cord-296347-fanlvxqs	739	53	,	,	,
cord-296347-fanlvxqs	739	54	2003	2003	CD
cord-296347-fanlvxqs	739	55	;	;	:
cord-296347-fanlvxqs	739	56	Tomazin	Tomazin	NNP
cord-296347-fanlvxqs	739	57	et	et	NNP
cord-296347-fanlvxqs	739	58	al	al	NNP
cord-296347-fanlvxqs	739	59	.	.	NNP
cord-296347-fanlvxqs	739	60	,	,	,
cord-296347-fanlvxqs	739	61	1999	1999	CD
cord-296347-fanlvxqs	739	62	)	)	-RRB-
cord-296347-fanlvxqs	739	63	.	.	.
cord-296347-fanlvxqs	740	1	This	this	DT
cord-296347-fanlvxqs	740	2	effect	effect	NN
cord-296347-fanlvxqs	740	3	of	of	IN
cord-296347-fanlvxqs	740	4	US2	US2	NNP
cord-296347-fanlvxqs	740	5	,	,	,
cord-296347-fanlvxqs	740	6	however	however	RB
cord-296347-fanlvxqs	740	7	,	,	,
cord-296347-fanlvxqs	740	8	was	be	VBD
cord-296347-fanlvxqs	740	9	only	only	RB
cord-296347-fanlvxqs	740	10	seen	see	VBN
cord-296347-fanlvxqs	740	11	in	in	IN
cord-296347-fanlvxqs	740	12	cell	cell	NN
cord-296347-fanlvxqs	740	13	lines	line	NNS
cord-296347-fanlvxqs	740	14	in	in	IN
cord-296347-fanlvxqs	740	15	which	which	WDT
cord-296347-fanlvxqs	740	16	induction	induction	NN
cord-296347-fanlvxqs	740	17	of	of	IN
cord-296347-fanlvxqs	740	18	class	class	NNP
cord-296347-fanlvxqs	740	19	II	II	NNP
cord-296347-fanlvxqs	740	20	MHC	MHC	NNP
cord-296347-fanlvxqs	740	21	was	be	VBD
cord-296347-fanlvxqs	740	22	induced	induce	VBN
cord-296347-fanlvxqs	740	23	by	by	IN
cord-296347-fanlvxqs	740	24	stable	stable	JJ
cord-296347-fanlvxqs	740	25	transfection	transfection	NN
cord-296347-fanlvxqs	740	26	with	with	IN
cord-296347-fanlvxqs	740	27	the	the	DT
cord-296347-fanlvxqs	740	28	class	class	NN
cord-296347-fanlvxqs	740	29	II	II	NNP
cord-296347-fanlvxqs	740	30	MHC	MHC	NNP
cord-296347-fanlvxqs	740	31	trans	trans	NNP
cord-296347-fanlvxqs	740	32	-	-	NN
cord-296347-fanlvxqs	740	33	activator	activator	NN
cord-296347-fanlvxqs	740	34	(	(	-LRB-
cord-296347-fanlvxqs	740	35	CIITA	CIITA	NNP
cord-296347-fanlvxqs	740	36	)	)	-RRB-
cord-296347-fanlvxqs	740	37	,	,	,
cord-296347-fanlvxqs	740	38	but	but	CC
cord-296347-fanlvxqs	740	39	not	not	RB
cord-296347-fanlvxqs	740	40	in	in	IN
cord-296347-fanlvxqs	740	41	human	human	JJ
cord-296347-fanlvxqs	740	42	DCs	dc	NNS
cord-296347-fanlvxqs	740	43	or	or	CC
cord-296347-fanlvxqs	740	44	several	several	JJ
cord-296347-fanlvxqs	740	45	other	other	JJ
cord-296347-fanlvxqs	740	46	cell	cell	NN
cord-296347-fanlvxqs	740	47	lines	line	NNS
cord-296347-fanlvxqs	740	48	,	,	,
cord-296347-fanlvxqs	740	49	which	which	WDT
cord-296347-fanlvxqs	740	50	express	express	VBP
cord-296347-fanlvxqs	740	51	class	class	NN
cord-296347-fanlvxqs	740	52	II	II	NNP
cord-296347-fanlvxqs	740	53	MHC	MHC	NNP
cord-296347-fanlvxqs	740	54	endogenously	endogenously	RB
cord-296347-fanlvxqs	740	55	(	(	-LRB-
cord-296347-fanlvxqs	740	56	Rehm	Rehm	NNP
cord-296347-fanlvxqs	740	57	et	et	NNP
cord-296347-fanlvxqs	740	58	al	al	NNP
cord-296347-fanlvxqs	740	59	.	.	NNP
cord-296347-fanlvxqs	740	60	,	,	,
cord-296347-fanlvxqs	740	61	2002	2002	CD
cord-296347-fanlvxqs	740	62	)	)	-RRB-
cord-296347-fanlvxqs	740	63	.	.	.
cord-296347-fanlvxqs	741	1	Presumably	presumably	RB
cord-296347-fanlvxqs	741	2	the	the	DT
cord-296347-fanlvxqs	741	3	relative	relative	JJ
cord-296347-fanlvxqs	741	4	expression	expression	NN
cord-296347-fanlvxqs	741	5	levels	level	NNS
cord-296347-fanlvxqs	741	6	of	of	IN
cord-296347-fanlvxqs	741	7	class	class	NN
cord-296347-fanlvxqs	741	8	II	II	NNP
cord-296347-fanlvxqs	741	9	MHC	MHC	NNP
cord-296347-fanlvxqs	741	10	and/or	and/or	CC
cord-296347-fanlvxqs	741	11	US2	US2	NNP
cord-296347-fanlvxqs	741	12	could	could	MD
cord-296347-fanlvxqs	741	13	account	account	VB
cord-296347-fanlvxqs	741	14	for	for	IN
cord-296347-fanlvxqs	741	15	the	the	DT
cord-296347-fanlvxqs	741	16	observed	observed	JJ
cord-296347-fanlvxqs	741	17	differences	difference	NNS
cord-296347-fanlvxqs	741	18	,	,	,
cord-296347-fanlvxqs	741	19	and	and	CC
cord-296347-fanlvxqs	741	20	in	in	IN
cord-296347-fanlvxqs	741	21	fact	fact	NN
cord-296347-fanlvxqs	741	22	,	,	,
cord-296347-fanlvxqs	741	23	in	in	IN
cord-296347-fanlvxqs	741	24	CIITA	CIITA	NNP
cord-296347-fanlvxqs	741	25	-	-	HYPH
cord-296347-fanlvxqs	741	26	transfected	transfecte	VBN
cord-296347-fanlvxqs	741	27	cells	cell	NNS
cord-296347-fanlvxqs	741	28	,	,	,
cord-296347-fanlvxqs	741	29	even	even	RB
cord-296347-fanlvxqs	741	30	US3	US3	NNP
cord-296347-fanlvxqs	741	31	was	be	VBD
cord-296347-fanlvxqs	741	32	seen	see	VBN
cord-296347-fanlvxqs	741	33	to	to	TO
cord-296347-fanlvxqs	741	34	downregulate	downregulate	VB
cord-296347-fanlvxqs	741	35	class	class	NN
cord-296347-fanlvxqs	741	36	II	II	NNP
cord-296347-fanlvxqs	741	37	MHC	MHC	NNP
cord-296347-fanlvxqs	741	38	molecules	molecule	NNS
cord-296347-fanlvxqs	741	39	(	(	-LRB-
cord-296347-fanlvxqs	741	40	Hegde	Hegde	NNP
cord-296347-fanlvxqs	741	41	et	et	NNP
cord-296347-fanlvxqs	741	42	al	al	NNP
cord-296347-fanlvxqs	741	43	.	.	NNP
cord-296347-fanlvxqs	741	44	,	,	,
cord-296347-fanlvxqs	741	45	2002	2002	CD
cord-296347-fanlvxqs	741	46	)	)	-RRB-
cord-296347-fanlvxqs	741	47	.	.	.
cord-296347-fanlvxqs	742	1	HSV-1	HSV-1	NNS
cord-296347-fanlvxqs	742	2	can	can	MD
cord-296347-fanlvxqs	742	3	downregulate	downregulate	VB
cord-296347-fanlvxqs	742	4	surface	surface	NN
cord-296347-fanlvxqs	742	5	expression	expression	NN
cord-296347-fanlvxqs	742	6	of	of	IN
cord-296347-fanlvxqs	742	7	class	class	NN
cord-296347-fanlvxqs	742	8	II	II	NNP
cord-296347-fanlvxqs	742	9	MHC	MHC	NNP
cord-296347-fanlvxqs	742	10	complexes	complex	NNS
cord-296347-fanlvxqs	742	11	in	in	IN
cord-296347-fanlvxqs	742	12	B	b	NN
cord-296347-fanlvxqs	742	13	cells	cell	NNS
cord-296347-fanlvxqs	742	14	and	and	CC
cord-296347-fanlvxqs	742	15	inhibits	inhibit	VBZ
cord-296347-fanlvxqs	742	16	the	the	DT
cord-296347-fanlvxqs	742	17	ability	ability	NN
cord-296347-fanlvxqs	742	18	of	of	IN
cord-296347-fanlvxqs	742	19	B	b	NN
cord-296347-fanlvxqs	742	20	cells	cell	NNS
cord-296347-fanlvxqs	742	21	to	to	TO
cord-296347-fanlvxqs	742	22	stimulate	stimulate	VB
cord-296347-fanlvxqs	742	23	CD4	CD4	NNP
cord-296347-fanlvxqs	742	24	þ	þ	NNP
cord-296347-fanlvxqs	742	25	T	t	NN
cord-296347-fanlvxqs	742	26	cells	cell	NNS
cord-296347-fanlvxqs	742	27	.	.	.
cord-296347-fanlvxqs	743	1	HSV-1	hsv-1	NN
cord-296347-fanlvxqs	743	2	inhibits	inhibit	VBZ
cord-296347-fanlvxqs	743	3	synthesis	synthesis	NN
cord-296347-fanlvxqs	743	4	of	of	IN
cord-296347-fanlvxqs	743	5	Ii	Ii	NNP
cord-296347-fanlvxqs	743	6	and	and	CC
cord-296347-fanlvxqs	743	7	also	also	RB
cord-296347-fanlvxqs	743	8	encodes	encode	VBZ
cord-296347-fanlvxqs	743	9	an	an	DT
cord-296347-fanlvxqs	743	10	envelope	envelope	NN
cord-296347-fanlvxqs	743	11	glycoprotein	glycoprotein	NN
cord-296347-fanlvxqs	743	12	B	B	NNP
cord-296347-fanlvxqs	743	13	(	(	-LRB-
cord-296347-fanlvxqs	743	14	gB	gB	NNP
cord-296347-fanlvxqs	743	15	)	)	-RRB-
cord-296347-fanlvxqs	743	16	that	that	WDT
cord-296347-fanlvxqs	743	17	binds	bind	VBZ
cord-296347-fanlvxqs	743	18	both	both	DT
cord-296347-fanlvxqs	743	19	HLA	HLA	NNP
cord-296347-fanlvxqs	743	20	-	-	HYPH
cord-296347-fanlvxqs	743	21	DR	DR	NNP
cord-296347-fanlvxqs	743	22	and	and	CC
cord-296347-fanlvxqs	743	23	HLA	HLA	NNP
cord-296347-fanlvxqs	743	24	-	-	HYPH
cord-296347-fanlvxqs	743	25	DM	DM	NNP
cord-296347-fanlvxqs	743	26	(	(	-LRB-
cord-296347-fanlvxqs	743	27	Neumann	Neumann	NNP
cord-296347-fanlvxqs	743	28	et	et	NNP
cord-296347-fanlvxqs	743	29	al	al	NNP
cord-296347-fanlvxqs	743	30	.	.	NNP
cord-296347-fanlvxqs	743	31	,	,	,
cord-296347-fanlvxqs	743	32	2003	2003	CD
cord-296347-fanlvxqs	743	33	;	;	:
cord-296347-fanlvxqs	743	34	Sievers	Sievers	NNP
cord-296347-fanlvxqs	743	35	et	et	NNP
cord-296347-fanlvxqs	743	36	al	al	NNP
cord-296347-fanlvxqs	743	37	.	.	NNP
cord-296347-fanlvxqs	743	38	,	,	,
cord-296347-fanlvxqs	743	39	2002	2002	CD
cord-296347-fanlvxqs	743	40	)	)	-RRB-
cord-296347-fanlvxqs	743	41	.	.	.
cord-296347-fanlvxqs	744	1	By	by	IN
cord-296347-fanlvxqs	744	2	binding	bind	VBG
cord-296347-fanlvxqs	744	3	to	to	IN
cord-296347-fanlvxqs	744	4	HLA	HLA	NNP
cord-296347-fanlvxqs	744	5	-	-	HYPH
cord-296347-fanlvxqs	744	6	DR	DR	NNP
cord-296347-fanlvxqs	744	7	,	,	,
cord-296347-fanlvxqs	744	8	gB	gB	NNP
cord-296347-fanlvxqs	744	9	affects	affect	VBZ
cord-296347-fanlvxqs	744	10	trafficking	trafficking	NN
cord-296347-fanlvxqs	744	11	of	of	IN
cord-296347-fanlvxqs	744	12	the	the	DT
cord-296347-fanlvxqs	744	13	molecule	molecule	NN
cord-296347-fanlvxqs	744	14	in	in	IN
cord-296347-fanlvxqs	744	15	the	the	DT
cord-296347-fanlvxqs	744	16	secretory	secretory	JJ
cord-296347-fanlvxqs	744	17	pathway	pathway	NN
cord-296347-fanlvxqs	744	18	and	and	CC
cord-296347-fanlvxqs	744	19	by	by	IN
cord-296347-fanlvxqs	744	20	binding	bind	VBG
cord-296347-fanlvxqs	744	21	HLA	HLA	NNP
cord-296347-fanlvxqs	744	22	-	-	HYPH
cord-296347-fanlvxqs	744	23	DM	DM	NNP
cord-296347-fanlvxqs	744	24	it	-PRON-	PRP
cord-296347-fanlvxqs	744	25	sequesters	sequester	VBZ
cord-296347-fanlvxqs	744	26	this	this	DT
cord-296347-fanlvxqs	744	27	peptide	peptide	NN
cord-296347-fanlvxqs	744	28	editor	editor	NN
cord-296347-fanlvxqs	744	29	and	and	CC
cord-296347-fanlvxqs	744	30	thus	thus	RB
cord-296347-fanlvxqs	744	31	prevents	prevent	VBZ
cord-296347-fanlvxqs	744	32	peptide	peptide	JJ
cord-296347-fanlvxqs	744	33	loading	loading	NN
cord-296347-fanlvxqs	744	34	of	of	IN
cord-296347-fanlvxqs	744	35	class	class	NN
cord-296347-fanlvxqs	744	36	II	II	NNP
cord-296347-fanlvxqs	744	37	MHC	MHC	NNP
cord-296347-fanlvxqs	744	38	molecules	molecule	NNS
cord-296347-fanlvxqs	744	39	that	that	WDT
cord-296347-fanlvxqs	744	40	may	may	MD
cord-296347-fanlvxqs	744	41	have	have	VB
cord-296347-fanlvxqs	744	42	escaped	escape	VBN
cord-296347-fanlvxqs	744	43	(	(	-LRB-
cord-296347-fanlvxqs	744	44	Neumann	Neumann	NNP
cord-296347-fanlvxqs	744	45	et	et	NNP
cord-296347-fanlvxqs	744	46	al	al	NNP
cord-296347-fanlvxqs	744	47	.	.	NNP
cord-296347-fanlvxqs	744	48	,	,	,
cord-296347-fanlvxqs	744	49	2003	2003	CD
cord-296347-fanlvxqs	744	50	)	)	-RRB-
cord-296347-fanlvxqs	744	51	.	.	.
cord-296347-fanlvxqs	745	1	The	the	DT
cord-296347-fanlvxqs	745	2	CD4	CD4	NNP
cord-296347-fanlvxqs	745	3	protein	protein	NN
cord-296347-fanlvxqs	745	4	serves	serve	VBZ
cord-296347-fanlvxqs	745	5	as	as	IN
cord-296347-fanlvxqs	745	6	the	the	DT
cord-296347-fanlvxqs	745	7	primary	primary	JJ
cord-296347-fanlvxqs	745	8	cellular	cellular	JJ
cord-296347-fanlvxqs	745	9	receptor	receptor	NN
cord-296347-fanlvxqs	745	10	for	for	IN
cord-296347-fanlvxqs	745	11	HIV	HIV	NNP
cord-296347-fanlvxqs	745	12	at	at	IN
cord-296347-fanlvxqs	745	13	the	the	DT
cord-296347-fanlvxqs	745	14	surface	surface	NN
cord-296347-fanlvxqs	745	15	of	of	IN
cord-296347-fanlvxqs	745	16	CD4	CD4	NNP
cord-296347-fanlvxqs	745	17	þ	þ	NNP
cord-296347-fanlvxqs	745	18	cells	cell	NNS
cord-296347-fanlvxqs	745	19	.	.	.
cord-296347-fanlvxqs	746	1	However	however	RB
cord-296347-fanlvxqs	746	2	,	,	,
cord-296347-fanlvxqs	746	3	its	-PRON-	PRP$
cord-296347-fanlvxqs	746	4	presence	presence	NN
cord-296347-fanlvxqs	746	5	inhibits	inhibit	VBZ
cord-296347-fanlvxqs	746	6	virus	virus	NN
cord-296347-fanlvxqs	746	7	budding	bud	VBG
cord-296347-fanlvxqs	746	8	and	and	CC
cord-296347-fanlvxqs	746	9	interferes	interfere	VBZ
cord-296347-fanlvxqs	746	10	with	with	IN
cord-296347-fanlvxqs	746	11	incorporation	incorporation	NN
cord-296347-fanlvxqs	746	12	of	of	IN
cord-296347-fanlvxqs	746	13	the	the	DT
cord-296347-fanlvxqs	746	14	gp120	gp120	NNP
cord-296347-fanlvxqs	746	15	protein	protein	NN
cord-296347-fanlvxqs	746	16	into	into	IN
cord-296347-fanlvxqs	746	17	the	the	DT
cord-296347-fanlvxqs	746	18	budding	bud	VBG
cord-296347-fanlvxqs	746	19	virion	virion	NN
cord-296347-fanlvxqs	746	20	,	,	,
cord-296347-fanlvxqs	746	21	not	not	RB
cord-296347-fanlvxqs	746	22	to	to	TO
cord-296347-fanlvxqs	746	23	mention	mention	VB
cord-296347-fanlvxqs	746	24	its	-PRON-	PRP$
cord-296347-fanlvxqs	746	25	crucial	crucial	JJ
cord-296347-fanlvxqs	746	26	role	role	NN
cord-296347-fanlvxqs	746	27	in	in	IN
cord-296347-fanlvxqs	746	28	eliciting	elicit	VBG
cord-296347-fanlvxqs	746	29	of	of	IN
cord-296347-fanlvxqs	746	30	a	a	DT
cord-296347-fanlvxqs	746	31	CD4	CD4	NNP
cord-296347-fanlvxqs	746	32	þ	þ	NNP
cord-296347-fanlvxqs	746	33	T	T	NNP
cord-296347-fanlvxqs	746	34	cell	cell	NN
cord-296347-fanlvxqs	746	35	response	response	NN
cord-296347-fanlvxqs	746	36	(	(	-LRB-
cord-296347-fanlvxqs	746	37	Keppler	Keppler	NNP
cord-296347-fanlvxqs	746	38	et	et	NNP
cord-296347-fanlvxqs	746	39	al	al	NNP
cord-296347-fanlvxqs	746	40	.	.	NNP
cord-296347-fanlvxqs	746	41	,	,	,
cord-296347-fanlvxqs	746	42	2006	2006	CD
cord-296347-fanlvxqs	746	43	;	;	:
cord-296347-fanlvxqs	746	44	Lama	Lama	NNP
cord-296347-fanlvxqs	746	45	et	et	FW
cord-296347-fanlvxqs	746	46	al	al	NNP
cord-296347-fanlvxqs	746	47	.	.	NNP
cord-296347-fanlvxqs	746	48	,	,	,
cord-296347-fanlvxqs	746	49	1999	1999	CD
cord-296347-fanlvxqs	746	50	;	;	:
cord-296347-fanlvxqs	746	51	Ross	Ross	NNP
cord-296347-fanlvxqs	746	52	et	et	NNP
cord-296347-fanlvxqs	746	53	al	al	NNP
cord-296347-fanlvxqs	746	54	.	.	NNP
cord-296347-fanlvxqs	746	55	,	,	,
cord-296347-fanlvxqs	746	56	1999	1999	CD
cord-296347-fanlvxqs	746	57	)	)	-RRB-
cord-296347-fanlvxqs	746	58	.	.	.
cord-296347-fanlvxqs	747	1	Not	not	RB
cord-296347-fanlvxqs	747	2	surprisingly	surprisingly	RB
cord-296347-fanlvxqs	747	3	,	,	,
cord-296347-fanlvxqs	747	4	three	three	CD
cord-296347-fanlvxqs	747	5	HIV-1	HIV-1	NNP
cord-296347-fanlvxqs	747	6	proteins	protein	NNS
cord-296347-fanlvxqs	747	7	,	,	,
cord-296347-fanlvxqs	747	8	Nef	Nef	NNP
cord-296347-fanlvxqs	747	9	,	,	,
cord-296347-fanlvxqs	747	10	Vpu	Vpu	NNP
cord-296347-fanlvxqs	747	11	,	,	,
cord-296347-fanlvxqs	747	12	and	and	CC
cord-296347-fanlvxqs	747	13	gp160	gp160	NNP
cord-296347-fanlvxqs	747	14	dramatically	dramatically	RB
cord-296347-fanlvxqs	747	15	reduce	reduce	VBP
cord-296347-fanlvxqs	747	16	the	the	DT
cord-296347-fanlvxqs	747	17	steady	steady	JJ
cord-296347-fanlvxqs	747	18	state	state	NN
cord-296347-fanlvxqs	747	19	levels	level	NNS
cord-296347-fanlvxqs	747	20	of	of	IN
cord-296347-fanlvxqs	747	21	CD4	CD4	NNP
cord-296347-fanlvxqs	747	22	on	on	IN
cord-296347-fanlvxqs	747	23	the	the	DT
cord-296347-fanlvxqs	747	24	cell	cell	NN
cord-296347-fanlvxqs	747	25	surface	surface	NN
cord-296347-fanlvxqs	747	26	Piguet	Piguet	NNP
cord-296347-fanlvxqs	747	27	et	et	NNP
cord-296347-fanlvxqs	747	28	al	al	NNP
cord-296347-fanlvxqs	747	29	.	.	NNP
cord-296347-fanlvxqs	747	30	,	,	,
cord-296347-fanlvxqs	747	31	1999a	1999a	CD
cord-296347-fanlvxqs	747	32	,	,	,
cord-296347-fanlvxqs	747	33	b	b	LS
cord-296347-fanlvxqs	747	34	)	)	-RRB-
cord-296347-fanlvxqs	747	35	.	.	.
cord-296347-fanlvxqs	748	1	One	one	CD
cord-296347-fanlvxqs	748	2	of	of	IN
cord-296347-fanlvxqs	748	3	the	the	DT
cord-296347-fanlvxqs	748	4	many	many	JJ
cord-296347-fanlvxqs	748	5	mechanisms	mechanism	NNS
cord-296347-fanlvxqs	748	6	used	use	VBN
cord-296347-fanlvxqs	748	7	by	by	IN
cord-296347-fanlvxqs	748	8	Nef	Nef	NNP
cord-296347-fanlvxqs	748	9	involves	involve	VBZ
cord-296347-fanlvxqs	748	10	acceleration	acceleration	NN
cord-296347-fanlvxqs	748	11	of	of	IN
cord-296347-fanlvxqs	748	12	the	the	DT
cord-296347-fanlvxqs	748	13	constitutive	constitutive	JJ
cord-296347-fanlvxqs	748	14	endocytosis	endocytosis	NN
cord-296347-fanlvxqs	748	15	of	of	IN
cord-296347-fanlvxqs	748	16	CD4	CD4	NNP
cord-296347-fanlvxqs	748	17	.	.	.
cord-296347-fanlvxqs	749	1	In	in	IN
cord-296347-fanlvxqs	749	2	T	T	NNP
cord-296347-fanlvxqs	749	3	cells	cell	NNS
cord-296347-fanlvxqs	749	4	,	,	,
cord-296347-fanlvxqs	749	5	CD4	CD4	NNP
cord-296347-fanlvxqs	749	6	is	be	VBZ
cord-296347-fanlvxqs	749	7	stabilized	stabilize	VBN
cord-296347-fanlvxqs	749	8	at	at	IN
cord-296347-fanlvxqs	749	9	the	the	DT
cord-296347-fanlvxqs	749	10	cell	cell	NN
cord-296347-fanlvxqs	749	11	surface	surface	NN
cord-296347-fanlvxqs	749	12	by	by	IN
cord-296347-fanlvxqs	750	1	p56Lck	p56Lck	NNP
cord-296347-fanlvxqs	750	2	,	,	,
cord-296347-fanlvxqs	750	3	a	a	DT
cord-296347-fanlvxqs	750	4	Src	Src	NNP
cord-296347-fanlvxqs	750	5	-	-	HYPH
cord-296347-fanlvxqs	750	6	family	family	NN
cord-296347-fanlvxqs	750	7	tyrosine	tyrosine	NN
cord-296347-fanlvxqs	750	8	kinase	kinase	NN
cord-296347-fanlvxqs	750	9	,	,	,
cord-296347-fanlvxqs	750	10	which	which	WDT
cord-296347-fanlvxqs	750	11	binds	bind	VBZ
cord-296347-fanlvxqs	750	12	a	a	DT
cord-296347-fanlvxqs	750	13	dileucine	dileucine	NN
cord-296347-fanlvxqs	750	14	motif	motif	NN
cord-296347-fanlvxqs	750	15	in	in	IN
cord-296347-fanlvxqs	750	16	the	the	DT
cord-296347-fanlvxqs	750	17	CD4	CD4	NNP
cord-296347-fanlvxqs	750	18	cytoplasmic	cytoplasmic	JJ
cord-296347-fanlvxqs	750	19	tail	tail	NN
cord-296347-fanlvxqs	750	20	,	,	,
cord-296347-fanlvxqs	750	21	preventing	prevent	VBG
cord-296347-fanlvxqs	750	22	CD4	CD4	NNP
cord-296347-fanlvxqs	750	23	from	from	IN
cord-296347-fanlvxqs	750	24	being	be	VBG
cord-296347-fanlvxqs	750	25	recruited	recruit	VBN
cord-296347-fanlvxqs	750	26	into	into	IN
cord-296347-fanlvxqs	750	27	clathrin	clathrin	NN
cord-296347-fanlvxqs	750	28	-	-	HYPH
cord-296347-fanlvxqs	750	29	coated	coat	VBN
cord-296347-fanlvxqs	750	30	pits	pit	NNS
cord-296347-fanlvxqs	750	31	(	(	-LRB-
cord-296347-fanlvxqs	750	32	Aiken	Aiken	NNP
cord-296347-fanlvxqs	750	33	et	et	NNP
cord-296347-fanlvxqs	750	34	al	al	NNP
cord-296347-fanlvxqs	750	35	.	.	NNP
cord-296347-fanlvxqs	750	36	,	,	,
cord-296347-fanlvxqs	750	37	1994	1994	CD
cord-296347-fanlvxqs	750	38	;	;	:
cord-296347-fanlvxqs	750	39	Jin	Jin	NNP
cord-296347-fanlvxqs	750	40	et	et	NNP
cord-296347-fanlvxqs	750	41	al	al	NNP
cord-296347-fanlvxqs	750	42	.	.	NNP
cord-296347-fanlvxqs	750	43	,	,	,
cord-296347-fanlvxqs	750	44	2005	2005	CD
cord-296347-fanlvxqs	750	45	)	)	-RRB-
cord-296347-fanlvxqs	750	46	.	.	.
cord-296347-fanlvxqs	751	1	Nef	Nef	NNP
cord-296347-fanlvxqs	751	2	can	can	MD
cord-296347-fanlvxqs	751	3	displace	displace	VB
cord-296347-fanlvxqs	751	4	Lck	Lck	NNP
cord-296347-fanlvxqs	751	5	by	by	IN
cord-296347-fanlvxqs	751	6	directly	directly	RB
cord-296347-fanlvxqs	751	7	binding	bind	VBG
cord-296347-fanlvxqs	751	8	a	a	DT
cord-296347-fanlvxqs	751	9	dileucine	dileucine	NN
cord-296347-fanlvxqs	751	10	sorting	sorting	NN
cord-296347-fanlvxqs	751	11	motif	motif	NN
cord-296347-fanlvxqs	751	12	in	in	IN
cord-296347-fanlvxqs	751	13	the	the	DT
cord-296347-fanlvxqs	751	14	CD4	CD4	NNP
cord-296347-fanlvxqs	751	15	tail	tail	NN
cord-296347-fanlvxqs	751	16	,	,	,
cord-296347-fanlvxqs	751	17	overcoming	overcome	VBG
cord-296347-fanlvxqs	751	18	the	the	DT
cord-296347-fanlvxqs	751	19	normal	normal	JJ
cord-296347-fanlvxqs	751	20	Lck	Lck	NNP
cord-296347-fanlvxqs	751	21	phosphorylation	phosphorylation	NN
cord-296347-fanlvxqs	751	22	-	-	HYPH
cord-296347-fanlvxqs	751	23	dependent	dependent	JJ
cord-296347-fanlvxqs	751	24	route	route	NN
cord-296347-fanlvxqs	751	25	of	of	IN
cord-296347-fanlvxqs	751	26	CD4	CD4	NNP
cord-296347-fanlvxqs	751	27	downregulation	downregulation	NN
cord-296347-fanlvxqs	751	28	.	.	.
cord-296347-fanlvxqs	752	1	Nef	Nef	NNP
cord-296347-fanlvxqs	752	2	itself	-PRON-	PRP
cord-296347-fanlvxqs	752	3	contains	contain	VBZ
cord-296347-fanlvxqs	752	4	a	a	DT
cord-296347-fanlvxqs	752	5	C	c	NN
cord-296347-fanlvxqs	752	6	-	-	HYPH
cord-296347-fanlvxqs	752	7	terminal	terminal	NN
cord-296347-fanlvxqs	752	8	dileucine	dileucine	NN
cord-296347-fanlvxqs	752	9	motif	motif	NN
cord-296347-fanlvxqs	752	10	that	that	WDT
cord-296347-fanlvxqs	752	11	recruits	recruit	VBZ
cord-296347-fanlvxqs	752	12	a	a	DT
cord-296347-fanlvxqs	752	13	subunit	subunit	NN
cord-296347-fanlvxqs	752	14	of	of	IN
cord-296347-fanlvxqs	752	15	the	the	DT
cord-296347-fanlvxqs	752	16	tetrameric	tetrameric	JJ
cord-296347-fanlvxqs	752	17	adaptor	adaptor	NN
cord-296347-fanlvxqs	752	18	protein	protein	NN
cord-296347-fanlvxqs	752	19	complex-2	complex-2	NNP
cord-296347-fanlvxqs	753	1	(	(	-LRB-
cord-296347-fanlvxqs	753	2	AP-2	AP-2	NNP
cord-296347-fanlvxqs	753	3	)	)	-RRB-
cord-296347-fanlvxqs	753	4	,	,	,
cord-296347-fanlvxqs	753	5	a	a	DT
cord-296347-fanlvxqs	753	6	component	component	NN
cord-296347-fanlvxqs	753	7	of	of	IN
cord-296347-fanlvxqs	753	8	clathrin	clathrin	NN
cord-296347-fanlvxqs	753	9	-	-	HYPH
cord-296347-fanlvxqs	753	10	coated	coat	VBN
cord-296347-fanlvxqs	753	11	pits	pit	NNS
cord-296347-fanlvxqs	753	12	at	at	IN
cord-296347-fanlvxqs	753	13	the	the	DT
cord-296347-fanlvxqs	753	14	cell	cell	NN
cord-296347-fanlvxqs	753	15	membrane	membrane	NN
cord-296347-fanlvxqs	753	16	.	.	.
cord-296347-fanlvxqs	754	1	Thus	thus	RB
cord-296347-fanlvxqs	754	2	,	,	,
cord-296347-fanlvxqs	754	3	Nef	Nef	NNP
cord-296347-fanlvxqs	754	4	connects	connect	VBZ
cord-296347-fanlvxqs	754	5	CD4	CD4	NNP
cord-296347-fanlvxqs	754	6	to	to	IN
cord-296347-fanlvxqs	754	7	AP-2	AP-2	NNP
cord-296347-fanlvxqs	754	8	on	on	IN
cord-296347-fanlvxqs	754	9	clathrin	clathrin	NN
cord-296347-fanlvxqs	754	10	-	-	HYPH
cord-296347-fanlvxqs	754	11	coated	coat	VBN
cord-296347-fanlvxqs	754	12	pits	pit	NNS
cord-296347-fanlvxqs	754	13	,	,	,
cord-296347-fanlvxqs	754	14	triggering	trigger	VBG
cord-296347-fanlvxqs	754	15	rapid	rapid	JJ
cord-296347-fanlvxqs	754	16	CD4	CD4	NNP
cord-296347-fanlvxqs	754	17	endocytosis	endocytosis	NN
cord-296347-fanlvxqs	754	18	(	(	-LRB-
cord-296347-fanlvxqs	754	19	Jin	Jin	NNP
cord-296347-fanlvxqs	754	20	et	et	NNP
cord-296347-fanlvxqs	754	21	al	al	NNP
cord-296347-fanlvxqs	754	22	.	.	NNP
cord-296347-fanlvxqs	754	23	,	,	,
cord-296347-fanlvxqs	754	24	2004b	2004b	CD
cord-296347-fanlvxqs	755	1	(	(	-LRB-
cord-296347-fanlvxqs	755	2	Jin	Jin	NNP
cord-296347-fanlvxqs	755	3	et	et	FW
cord-296347-fanlvxqs	755	4	al	al	NNP
cord-296347-fanlvxqs	755	5	.	.	.
cord-296347-fanlvxqs	756	1	,	,	,
cord-296347-fanlvxqs	756	2	,	,	,
cord-296347-fanlvxqs	756	3	2005	2005	CD
cord-296347-fanlvxqs	757	1	Mangasarian	Mangasarian	NNP
cord-296347-fanlvxqs	757	2	et	et	NNP
cord-296347-fanlvxqs	757	3	al	al	NNP
cord-296347-fanlvxqs	757	4	.	.	.
cord-296347-fanlvxqs	758	1	,	,	,
cord-296347-fanlvxqs	758	2	1999	1999	CD
cord-296347-fanlvxqs	758	3	;	;	:
cord-296347-fanlvxqs	758	4	Piguet	Piguet	NNP
cord-296347-fanlvxqs	758	5	et	et	NNP
cord-296347-fanlvxqs	758	6	al	al	NNP
cord-296347-fanlvxqs	758	7	.	.	NNP
cord-296347-fanlvxqs	758	8	,	,	,
cord-296347-fanlvxqs	759	1	1998	1998	CD
cord-296347-fanlvxqs	760	1	Piguet	Piguet	NNP
cord-296347-fanlvxqs	760	2	et	et	NNP
cord-296347-fanlvxqs	760	3	al	al	NNP
cord-296347-fanlvxqs	760	4	.	.	.
cord-296347-fanlvxqs	761	1	,	,	,
cord-296347-fanlvxqs	761	2	,	,	,
cord-296347-fanlvxqs	761	3	1999a	1999a	CD
cord-296347-fanlvxqs	761	4	.	.	.
cord-296347-fanlvxqs	762	1	Nef	Nef	NNP
cord-296347-fanlvxqs	762	2	can	can	MD
cord-296347-fanlvxqs	762	3	bind	bind	VB
cord-296347-fanlvxqs	762	4	not	not	RB
cord-296347-fanlvxqs	762	5	only	only	RB
cord-296347-fanlvxqs	762	6	the	the	DT
cord-296347-fanlvxqs	762	7	AP-2	AP-2	NNP
cord-296347-fanlvxqs	762	8	components	component	NNS
cord-296347-fanlvxqs	762	9	of	of	IN
cord-296347-fanlvxqs	762	10	clathrin	clathrin	NN
cord-296347-fanlvxqs	762	11	-	-	HYPH
cord-296347-fanlvxqs	762	12	coated	coat	VBN
cord-296347-fanlvxqs	762	13	pits	pit	NNS
cord-296347-fanlvxqs	762	14	,	,	,
cord-296347-fanlvxqs	762	15	but	but	CC
cord-296347-fanlvxqs	762	16	also	also	RB
cord-296347-fanlvxqs	762	17	the	the	DT
cord-296347-fanlvxqs	762	18	regulatory	regulatory	JJ
cord-296347-fanlvxqs	762	19	V1H	v1h	NN
cord-296347-fanlvxqs	762	20	subunit	subunit	NN
cord-296347-fanlvxqs	762	21	of	of	IN
cord-296347-fanlvxqs	762	22	the	the	DT
cord-296347-fanlvxqs	762	23	vacuolar	vacuolar	JJ
cord-296347-fanlvxqs	762	24	proton	proton	NN
cord-296347-fanlvxqs	762	25	(	(	-LRB-
cord-296347-fanlvxqs	762	26	H	H	NNP
cord-296347-fanlvxqs	762	27	þ	þ	NNP
cord-296347-fanlvxqs	762	28	)	)	-RRB-
cord-296347-fanlvxqs	762	29	ATPase	ATPase	NNP
cord-296347-fanlvxqs	762	30	.	.	.
cord-296347-fanlvxqs	763	1	V1H	v1h	NN
cord-296347-fanlvxqs	764	1	(	(	-LRB-
cord-296347-fanlvxqs	764	2	also	also	RB
cord-296347-fanlvxqs	764	3	called	call	VBN
cord-296347-fanlvxqs	764	4	NBP1	NBP1	NNP
cord-296347-fanlvxqs	764	5	or	or	CC
cord-296347-fanlvxqs	764	6	Nef	Nef	NNP
cord-296347-fanlvxqs	764	7	binding	bind	VBG
cord-296347-fanlvxqs	764	8	protein-1	protein-1	NNP
cord-296347-fanlvxqs	764	9	)	)	-RRB-
cord-296347-fanlvxqs	764	10	binds	bind	VBZ
cord-296347-fanlvxqs	764	11	AP-2	AP-2	NNP
cord-296347-fanlvxqs	764	12	in	in	IN
cord-296347-fanlvxqs	764	13	clathrin	clathrin	NN
cord-296347-fanlvxqs	764	14	-	-	HYPH
cord-296347-fanlvxqs	764	15	coated	coat	VBN
cord-296347-fanlvxqs	764	16	vesicles	vesicle	NNS
cord-296347-fanlvxqs	764	17	.	.	.
cord-296347-fanlvxqs	765	1	By	by	IN
cord-296347-fanlvxqs	765	2	binding	bind	VBG
cord-296347-fanlvxqs	765	3	V1H	v1h	NN
cord-296347-fanlvxqs	765	4	,	,	,
cord-296347-fanlvxqs	765	5	Nef	Nef	NNP
cord-296347-fanlvxqs	765	6	strengthens	strengthen	VBZ
cord-296347-fanlvxqs	765	7	its	-PRON-	PRP$
cord-296347-fanlvxqs	765	8	weak	weak	JJ
cord-296347-fanlvxqs	765	9	direct	direct	JJ
cord-296347-fanlvxqs	765	10	interaction	interaction	NN
cord-296347-fanlvxqs	765	11	with	with	IN
cord-296347-fanlvxqs	765	12	AP-2	AP-2	NNP
cord-296347-fanlvxqs	765	13	(	(	-LRB-
cord-296347-fanlvxqs	765	14	Geyer	Geyer	NNP
cord-296347-fanlvxqs	765	15	et	et	NNP
cord-296347-fanlvxqs	765	16	al	al	NNP
cord-296347-fanlvxqs	765	17	.	.	NNP
cord-296347-fanlvxqs	765	18	,	,	,
cord-296347-fanlvxqs	765	19	2002	2002	CD
cord-296347-fanlvxqs	765	20	;	;	:
cord-296347-fanlvxqs	765	21	Mandic	Mandic	NNP
cord-296347-fanlvxqs	765	22	et	et	NNP
cord-296347-fanlvxqs	765	23	al	al	NNP
cord-296347-fanlvxqs	765	24	.	.	NNP
cord-296347-fanlvxqs	765	25	,	,	,
cord-296347-fanlvxqs	765	26	2001	2001	CD
cord-296347-fanlvxqs	765	27	)	)	-RRB-
cord-296347-fanlvxqs	765	28	.	.	.
cord-296347-fanlvxqs	766	1	Again	again	RB
cord-296347-fanlvxqs	766	2	,	,	,
cord-296347-fanlvxqs	766	3	by	by	IN
cord-296347-fanlvxqs	766	4	binding	bind	VBG
cord-296347-fanlvxqs	766	5	both	both	DT
cord-296347-fanlvxqs	766	6	CD4	CD4	NNP
cord-296347-fanlvxqs	766	7	(	(	-LRB-
cord-296347-fanlvxqs	766	8	using	use	VBG
cord-296347-fanlvxqs	766	9	the	the	DT
cord-296347-fanlvxqs	766	10	aforementioned	aforementioned	JJ
cord-296347-fanlvxqs	766	11	dileucine	dileucine	NN
cord-296347-fanlvxqs	766	12	motif	motif	NN
cord-296347-fanlvxqs	766	13	in	in	IN
cord-296347-fanlvxqs	766	14	the	the	DT
cord-296347-fanlvxqs	766	15	cytoplasmic	cytoplasmic	JJ
cord-296347-fanlvxqs	766	16	tail	tail	NN
cord-296347-fanlvxqs	766	17	)	)	-RRB-
cord-296347-fanlvxqs	766	18	and	and	CC
cord-296347-fanlvxqs	766	19	V1H	v1h	NN
cord-296347-fanlvxqs	766	20	,	,	,
cord-296347-fanlvxqs	766	21	Nef	Nef	NNP
cord-296347-fanlvxqs	766	22	directs	direct	VBZ
cord-296347-fanlvxqs	766	23	internalization	internalization	NN
cord-296347-fanlvxqs	766	24	of	of	IN
cord-296347-fanlvxqs	766	25	CD4	CD4	NNP
cord-296347-fanlvxqs	766	26	from	from	IN
cord-296347-fanlvxqs	766	27	the	the	DT
cord-296347-fanlvxqs	766	28	cell	cell	NN
cord-296347-fanlvxqs	766	29	surface	surface	NN
cord-296347-fanlvxqs	766	30	.	.	.
cord-296347-fanlvxqs	767	1	The	the	DT
cord-296347-fanlvxqs	767	2	endocytosed	endocytosed	JJ
cord-296347-fanlvxqs	767	3	CD4	CD4	NNP
cord-296347-fanlvxqs	767	4	accumulates	accumulate	VBZ
cord-296347-fanlvxqs	767	5	in	in	IN
cord-296347-fanlvxqs	767	6	early	early	JJ
cord-296347-fanlvxqs	767	7	endosomes	endosome	NNS
cord-296347-fanlvxqs	767	8	from	from	IN
cord-296347-fanlvxqs	767	9	where	where	WRB
cord-296347-fanlvxqs	767	10	it	-PRON-	PRP
cord-296347-fanlvxqs	767	11	is	be	VBZ
cord-296347-fanlvxqs	767	12	sorted	sort	VBN
cord-296347-fanlvxqs	767	13	to	to	IN
cord-296347-fanlvxqs	767	14	lysosomes	lysosome	NNS
cord-296347-fanlvxqs	767	15	for	for	IN
cord-296347-fanlvxqs	767	16	degradation	degradation	NN
cord-296347-fanlvxqs	767	17	.	.	.
cord-296347-fanlvxqs	768	1	Adaptor	adaptor	NN
cord-296347-fanlvxqs	768	2	protein	protein	NN
cord-296347-fanlvxqs	768	3	(	(	-LRB-
cord-296347-fanlvxqs	768	4	AP	AP	NNP
cord-296347-fanlvxqs	768	5	)	)	-RRB-
cord-296347-fanlvxqs	768	6	complexes	complex	NNS
cord-296347-fanlvxqs	768	7	mediate	mediate	VBP
cord-296347-fanlvxqs	768	8	transport	transport	NN
cord-296347-fanlvxqs	768	9	of	of	IN
cord-296347-fanlvxqs	768	10	proteins	protein	NNS
cord-296347-fanlvxqs	768	11	to	to	IN
cord-296347-fanlvxqs	768	12	numerous	numerous	JJ
cord-296347-fanlvxqs	768	13	compartments	compartment	NNS
cord-296347-fanlvxqs	768	14	within	within	IN
cord-296347-fanlvxqs	768	15	the	the	DT
cord-296347-fanlvxqs	768	16	cell	cell	NN
cord-296347-fanlvxqs	768	17	.	.	.
cord-296347-fanlvxqs	769	1	Whereas	whereas	IN
cord-296347-fanlvxqs	769	2	AP-2	AP-2	NNP
cord-296347-fanlvxqs	769	3	initiates	initiate	VBZ
cord-296347-fanlvxqs	769	4	early	early	RB
cord-296347-fanlvxqs	769	5	endocytic	endocytic	JJ
cord-296347-fanlvxqs	769	6	vesicle	vesicle	NN
cord-296347-fanlvxqs	769	7	formation	formation	NN
cord-296347-fanlvxqs	769	8	at	at	IN
cord-296347-fanlvxqs	769	9	the	the	DT
cord-296347-fanlvxqs	769	10	cell	cell	NN
cord-296347-fanlvxqs	769	11	membrane	membrane	NN
cord-296347-fanlvxqs	769	12	,	,	.
cord-296347-fanlvxqs	770	1	AP-1	AP-1	NNP
cord-296347-fanlvxqs	770	2	is	be	VBZ
cord-296347-fanlvxqs	770	3	involved	involve	VBN
cord-296347-fanlvxqs	770	4	in	in	IN
cord-296347-fanlvxqs	770	5	vesicle	vesicle	NN
cord-296347-fanlvxqs	770	6	formation	formation	NN
cord-296347-fanlvxqs	770	7	at	at	IN
cord-296347-fanlvxqs	770	8	the	the	DT
cord-296347-fanlvxqs	770	9	TGN	TGN	NNP
cord-296347-fanlvxqs	770	10	and	and	CC
cord-296347-fanlvxqs	770	11	vesicle	vesicle	NN
cord-296347-fanlvxqs	770	12	targeting	target	VBG
cord-296347-fanlvxqs	770	13	to	to	IN
cord-296347-fanlvxqs	770	14	early	early	JJ
cord-296347-fanlvxqs	770	15	endosomes	endosome	NNS
cord-296347-fanlvxqs	770	16	and	and	CC
cord-296347-fanlvxqs	770	17	AP-3	AP-3	NNP
cord-296347-fanlvxqs	770	18	participates	participate	VBZ
cord-296347-fanlvxqs	770	19	in	in	IN
cord-296347-fanlvxqs	770	20	vesicle	vesicle	NN
cord-296347-fanlvxqs	770	21	formation	formation	NN
cord-296347-fanlvxqs	770	22	at	at	IN
cord-296347-fanlvxqs	770	23	the	the	DT
cord-296347-fanlvxqs	770	24	TGN	TGN	NNP
cord-296347-fanlvxqs	770	25	and	and	CC
cord-296347-fanlvxqs	770	26	targeting	target	VBG
cord-296347-fanlvxqs	770	27	to	to	IN
cord-296347-fanlvxqs	770	28	late	late	JJ
cord-296347-fanlvxqs	770	29	endocytic	endocytic	NNP
cord-296347-fanlvxqs	770	30	/	/	SYM
cord-296347-fanlvxqs	770	31	lysosomal	lysosomal	JJ
cord-296347-fanlvxqs	770	32	compartments	compartment	NNS
cord-296347-fanlvxqs	770	33	(	(	-LRB-
cord-296347-fanlvxqs	770	34	Bonifacino	Bonifacino	NNP
cord-296347-fanlvxqs	770	35	and	and	CC
cord-296347-fanlvxqs	770	36	Traub	Traub	NNP
cord-296347-fanlvxqs	770	37	,	,	,
cord-296347-fanlvxqs	770	38	2003	2003	CD
cord-296347-fanlvxqs	770	39	)	)	-RRB-
cord-296347-fanlvxqs	770	40	.	.	.
cord-296347-fanlvxqs	771	1	The	the	DT
cord-296347-fanlvxqs	771	2	'	'	``
cord-296347-fanlvxqs	771	3	'	'	``
cord-296347-fanlvxqs	771	4	coat	coat	NN
cord-296347-fanlvxqs	771	5	'	'	''
cord-296347-fanlvxqs	771	6	'	'	''
cord-296347-fanlvxqs	771	7	on	on	IN
cord-296347-fanlvxqs	771	8	vesicles	vesicle	NNS
cord-296347-fanlvxqs	771	9	in	in	IN
cord-296347-fanlvxqs	771	10	the	the	DT
cord-296347-fanlvxqs	771	11	endocytic	endocytic	JJ
cord-296347-fanlvxqs	771	12	pathway	pathway	NN
cord-296347-fanlvxqs	771	13	is	be	VBZ
cord-296347-fanlvxqs	771	14	composed	compose	VBN
cord-296347-fanlvxqs	771	15	of	of	IN
cord-296347-fanlvxqs	771	16	AP	AP	NNP
cord-296347-fanlvxqs	771	17	complexes	complex	NNS
cord-296347-fanlvxqs	771	18	and	and	CC
cord-296347-fanlvxqs	771	19	another	another	DT
cord-296347-fanlvxqs	771	20	set	set	NN
cord-296347-fanlvxqs	771	21	of	of	IN
cord-296347-fanlvxqs	771	22	coat	coat	NN
cord-296347-fanlvxqs	771	23	proteins	protein	NNS
cord-296347-fanlvxqs	771	24	,	,	,
cord-296347-fanlvxqs	771	25	clathrin	clathrin	VBP
cord-296347-fanlvxqs	771	26	in	in	IN
cord-296347-fanlvxqs	771	27	clathrin	clathrin	NN
cord-296347-fanlvxqs	771	28	-	-	HYPH
cord-296347-fanlvxqs	771	29	coated	coat	VBN
cord-296347-fanlvxqs	771	30	vesicles	vesicle	NNS
cord-296347-fanlvxqs	771	31	,	,	,
cord-296347-fanlvxqs	771	32	and	and	CC
cord-296347-fanlvxqs	771	33	COP	cop	NN
cord-296347-fanlvxqs	771	34	proteins	protein	NNS
cord-296347-fanlvxqs	771	35	,	,	,
cord-296347-fanlvxqs	771	36	in	in	IN
cord-296347-fanlvxqs	771	37	COP	cop	NN
cord-296347-fanlvxqs	771	38	-	-	HYPH
cord-296347-fanlvxqs	771	39	coated	coat	VBN
cord-296347-fanlvxqs	771	40	vesicles	vesicle	NNS
cord-296347-fanlvxqs	771	41	.	.	.
cord-296347-fanlvxqs	772	1	The	the	DT
cord-296347-fanlvxqs	772	2	COP	cop	NN
cord-296347-fanlvxqs	772	3	proteins	protein	NNS
cord-296347-fanlvxqs	772	4	are	be	VBP
cord-296347-fanlvxqs	772	5	involved	involve	VBN
cord-296347-fanlvxqs	772	6	in	in	IN
cord-296347-fanlvxqs	772	7	vesicle	vesicle	NN
cord-296347-fanlvxqs	772	8	trafficking	traffic	VBG
cord-296347-fanlvxqs	772	9	early	early	RB
cord-296347-fanlvxqs	772	10	in	in	IN
cord-296347-fanlvxqs	772	11	the	the	DT
cord-296347-fanlvxqs	772	12	secretory	secretory	JJ
cord-296347-fanlvxqs	772	13	pathway	pathway	NN
cord-296347-fanlvxqs	772	14	between	between	IN
cord-296347-fanlvxqs	772	15	the	the	DT
cord-296347-fanlvxqs	772	16	ER	ER	NNP
cord-296347-fanlvxqs	772	17	and	and	CC
cord-296347-fanlvxqs	772	18	the	the	DT
cord-296347-fanlvxqs	772	19	Golgi	Golgi	NNP
cord-296347-fanlvxqs	772	20	(	(	-LRB-
cord-296347-fanlvxqs	772	21	McMahon	McMahon	NNP
cord-296347-fanlvxqs	772	22	and	and	CC
cord-296347-fanlvxqs	772	23	Mills	Mills	NNP
cord-296347-fanlvxqs	772	24	,	,	,
cord-296347-fanlvxqs	772	25	2004	2004	CD
cord-296347-fanlvxqs	772	26	)	)	-RRB-
cord-296347-fanlvxqs	772	27	.	.	.
cord-296347-fanlvxqs	773	1	Trafficking	traffic	VBG
cord-296347-fanlvxqs	773	2	in	in	IN
cord-296347-fanlvxqs	773	3	the	the	DT
cord-296347-fanlvxqs	773	4	endocytic	endocytic	JJ
cord-296347-fanlvxqs	773	5	pathway	pathway	NN
cord-296347-fanlvxqs	773	6	can	can	MD
cord-296347-fanlvxqs	773	7	be	be	VB
cord-296347-fanlvxqs	773	8	targeted	target	VBN
cord-296347-fanlvxqs	773	9	by	by	IN
cord-296347-fanlvxqs	773	10	HIV	HIV	NNP
cord-296347-fanlvxqs	773	11	Nef	Nef	NNP
cord-296347-fanlvxqs	773	12	by	by	IN
cord-296347-fanlvxqs	773	13	direct	direct	JJ
cord-296347-fanlvxqs	773	14	binding	binding	NN
cord-296347-fanlvxqs	773	15	to	to	IN
cord-296347-fanlvxqs	773	16	AP	AP	NNP
cord-296347-fanlvxqs	773	17	complexes	complex	NNS
cord-296347-fanlvxqs	773	18	or	or	CC
cord-296347-fanlvxqs	773	19	by	by	IN
cord-296347-fanlvxqs	773	20	interference	interference	NN
cord-296347-fanlvxqs	773	21	with	with	IN
cord-296347-fanlvxqs	773	22	the	the	DT
cord-296347-fanlvxqs	773	23	recruitment	recruitment	NN
cord-296347-fanlvxqs	773	24	and	and	CC
cord-296347-fanlvxqs	773	25	release	release	VB
cord-296347-fanlvxqs	773	26	cycles	cycle	NNS
cord-296347-fanlvxqs	773	27	of	of	IN
cord-296347-fanlvxqs	773	28	AP	AP	NNP
cord-296347-fanlvxqs	773	29	complexes	complex	NNS
cord-296347-fanlvxqs	773	30	from	from	IN
cord-296347-fanlvxqs	773	31	vesicle	vesicle	NN
cord-296347-fanlvxqs	773	32	membranes	membrane	NNS
cord-296347-fanlvxqs	773	33	.	.	.
cord-296347-fanlvxqs	774	1	AP	AP	NNP
cord-296347-fanlvxqs	774	2	complexes	complex	NNS
cord-296347-fanlvxqs	774	3	cycle	cycle	VBP
cord-296347-fanlvxqs	774	4	from	from	IN
cord-296347-fanlvxqs	774	5	the	the	DT
cord-296347-fanlvxqs	774	6	cytosol	cytosol	NN
cord-296347-fanlvxqs	774	7	to	to	IN
cord-296347-fanlvxqs	774	8	vesicles	vesicle	NNS
cord-296347-fanlvxqs	774	9	in	in	IN
cord-296347-fanlvxqs	774	10	a	a	DT
cord-296347-fanlvxqs	774	11	process	process	NN
cord-296347-fanlvxqs	774	12	dependent	dependent	JJ
cord-296347-fanlvxqs	774	13	on	on	IN
cord-296347-fanlvxqs	774	14	the	the	DT
cord-296347-fanlvxqs	774	15	GTPase	GTPase	NNP
cord-296347-fanlvxqs	774	16	cycle	cycle	NN
cord-296347-fanlvxqs	774	17	of	of	IN
cord-296347-fanlvxqs	774	18	ADP	ADP	NNP
cord-296347-fanlvxqs	774	19	-	-	HYPH
cord-296347-fanlvxqs	774	20	ribosylation	ribosylation	NNP
cord-296347-fanlvxqs	774	21	factor-1	factor-1	NNP
cord-296347-fanlvxqs	774	22	(	(	-LRB-
cord-296347-fanlvxqs	774	23	ARF1	ARF1	NNP
cord-296347-fanlvxqs	774	24	)	)	-RRB-
cord-296347-fanlvxqs	774	25	.	.	.
cord-296347-fanlvxqs	775	1	Nef	Nef	NNP
cord-296347-fanlvxqs	775	2	can	can	MD
cord-296347-fanlvxqs	775	3	bind	bind	VB
cord-296347-fanlvxqs	775	4	to	to	TO
cord-296347-fanlvxqs	775	5	and	and	CC
cord-296347-fanlvxqs	775	6	stabilize	stabilize	VB
cord-296347-fanlvxqs	775	7	the	the	DT
cord-296347-fanlvxqs	775	8	small	small	JJ
cord-296347-fanlvxqs	775	9	GTPase	GTPase	NNP
cord-296347-fanlvxqs	775	10	ARF1	ARF1	NNP
cord-296347-fanlvxqs	775	11	on	on	IN
cord-296347-fanlvxqs	775	12	the	the	DT
cord-296347-fanlvxqs	775	13	endosomal	endosomal	NNP
cord-296347-fanlvxqs	775	14	membrane	membrane	NN
cord-296347-fanlvxqs	775	15	,	,	,
cord-296347-fanlvxqs	775	16	preventing	prevent	VBG
cord-296347-fanlvxqs	775	17	AP	AP	NNP
cord-296347-fanlvxqs	775	18	complexes	complex	NNS
cord-296347-fanlvxqs	775	19	from	from	IN
cord-296347-fanlvxqs	775	20	being	be	VBG
cord-296347-fanlvxqs	775	21	released	release	VBN
cord-296347-fanlvxqs	775	22	,	,	,
cord-296347-fanlvxqs	775	23	affecting	affect	VBG
cord-296347-fanlvxqs	775	24	trafficking	trafficking	NN
cord-296347-fanlvxqs	775	25	of	of	IN
cord-296347-fanlvxqs	775	26	host	host	NN
cord-296347-fanlvxqs	775	27	molecules	molecule	NNS
cord-296347-fanlvxqs	775	28	(	(	-LRB-
cord-296347-fanlvxqs	775	29	including	include	VBG
cord-296347-fanlvxqs	775	30	CD4	CD4	NNP
cord-296347-fanlvxqs	775	31	)	)	-RRB-
cord-296347-fanlvxqs	775	32	along	along	IN
cord-296347-fanlvxqs	775	33	the	the	DT
cord-296347-fanlvxqs	775	34	endocytic	endocytic	JJ
cord-296347-fanlvxqs	775	35	pathway	pathway	NN
cord-296347-fanlvxqs	775	36	.	.	.
cord-296347-fanlvxqs	776	1	Nef	Nef	NNP
cord-296347-fanlvxqs	776	2	can	can	MD
cord-296347-fanlvxqs	776	3	also	also	RB
cord-296347-fanlvxqs	776	4	mediate	mediate	VB
cord-296347-fanlvxqs	776	5	the	the	DT
cord-296347-fanlvxqs	776	6	formation	formation	NN
cord-296347-fanlvxqs	776	7	of	of	IN
cord-296347-fanlvxqs	776	8	a	a	DT
cord-296347-fanlvxqs	776	9	ternary	ternary	JJ
cord-296347-fanlvxqs	776	10	complex	complex	NN
cord-296347-fanlvxqs	776	11	composed	compose	VBN
cord-296347-fanlvxqs	776	12	of	of	IN
cord-296347-fanlvxqs	776	13	Nef	Nef	NNP
cord-296347-fanlvxqs	776	14	,	,	,
cord-296347-fanlvxqs	776	15	ARF1	ARF1	NNP
cord-296347-fanlvxqs	776	16	,	,	,
cord-296347-fanlvxqs	776	17	and	and	CC
cord-296347-fanlvxqs	776	18	a	a	DT
cord-296347-fanlvxqs	776	19	component	component	NN
cord-296347-fanlvxqs	776	20	of	of	IN
cord-296347-fanlvxqs	776	21	the	the	DT
cord-296347-fanlvxqs	776	22	COP	cop	NN
cord-296347-fanlvxqs	776	23	-	-	:
cord-296347-fanlvxqs	776	24	I	i	NN
cord-296347-fanlvxqs	776	25	coat	coat	NN
cord-296347-fanlvxqs	776	26	,	,	,
cord-296347-fanlvxqs	776	27	bCOP	bcop	JJ
cord-296347-fanlvxqs	776	28	.	.	.
cord-296347-fanlvxqs	777	1	COP	cop	NN
cord-296347-fanlvxqs	777	2	-	-	HYPH
cord-296347-fanlvxqs	777	3	I	i	NN
cord-296347-fanlvxqs	777	4	-	-	HYPH
cord-296347-fanlvxqs	777	5	coated	coat	VBN
cord-296347-fanlvxqs	777	6	vesicles	vesicle	NNS
cord-296347-fanlvxqs	777	7	are	be	VBP
cord-296347-fanlvxqs	777	8	mostly	mostly	RB
cord-296347-fanlvxqs	777	9	subject	subject	JJ
cord-296347-fanlvxqs	777	10	to	to	IN
cord-296347-fanlvxqs	777	11	retrograde	retrograde	JJ
cord-296347-fanlvxqs	777	12	transport	transport	NN
cord-296347-fanlvxqs	777	13	within	within	IN
cord-296347-fanlvxqs	777	14	the	the	DT
cord-296347-fanlvxqs	777	15	Golgi	Golgi	NNP
cord-296347-fanlvxqs	777	16	and	and	CC
cord-296347-fanlvxqs	777	17	between	between	IN
cord-296347-fanlvxqs	777	18	the	the	DT
cord-296347-fanlvxqs	777	19	Golgi	Golgi	NNP
cord-296347-fanlvxqs	777	20	and	and	CC
cord-296347-fanlvxqs	777	21	the	the	DT
cord-296347-fanlvxqs	777	22	ER	ER	NNP
cord-296347-fanlvxqs	777	23	,	,	,
cord-296347-fanlvxqs	777	24	but	but	CC
cord-296347-fanlvxqs	777	25	some	some	DT
cord-296347-fanlvxqs	777	26	are	be	VBP
cord-296347-fanlvxqs	777	27	involved	involve	VBN
cord-296347-fanlvxqs	777	28	in	in	IN
cord-296347-fanlvxqs	777	29	transport	transport	NN
cord-296347-fanlvxqs	777	30	from	from	IN
cord-296347-fanlvxqs	777	31	early	early	RB
cord-296347-fanlvxqs	777	32	to	to	IN
cord-296347-fanlvxqs	777	33	late	late	JJ
cord-296347-fanlvxqs	777	34	endosomes	endosome	NNS
cord-296347-fanlvxqs	777	35	(	(	-LRB-
cord-296347-fanlvxqs	777	36	McMahon	McMahon	NNP
cord-296347-fanlvxqs	777	37	and	and	CC
cord-296347-fanlvxqs	777	38	Mills	Mills	NNP
cord-296347-fanlvxqs	777	39	,	,	,
cord-296347-fanlvxqs	777	40	2004	2004	CD
cord-296347-fanlvxqs	777	41	)	)	-RRB-
cord-296347-fanlvxqs	777	42	,	,	,
cord-296347-fanlvxqs	777	43	and	and	CC
cord-296347-fanlvxqs	777	44	thus	thus	RB
cord-296347-fanlvxqs	777	45	association	association	NN
cord-296347-fanlvxqs	777	46	of	of	IN
cord-296347-fanlvxqs	777	47	Nef	Nef	NNP
cord-296347-fanlvxqs	777	48	with	with	IN
cord-296347-fanlvxqs	777	49	ARF1	ARF1	NNP
cord-296347-fanlvxqs	777	50	and	and	CC
cord-296347-fanlvxqs	777	51	bCOP	bcop	NN
cord-296347-fanlvxqs	777	52	mediates	mediate	VBZ
cord-296347-fanlvxqs	777	53	targeting	target	VBG
cord-296347-fanlvxqs	777	54	of	of	IN
cord-296347-fanlvxqs	777	55	CD4	CD4	NNP
cord-296347-fanlvxqs	777	56	for	for	IN
cord-296347-fanlvxqs	777	57	lysosomal	lysosomal	JJ
cord-296347-fanlvxqs	777	58	degradation	degradation	NN
cord-296347-fanlvxqs	777	59	(	(	-LRB-
cord-296347-fanlvxqs	778	1	Faure	Faure	NNP
cord-296347-fanlvxqs	778	2	et	et	NNP
cord-296347-fanlvxqs	778	3	al	al	NNP
cord-296347-fanlvxqs	778	4	.	.	NNP
cord-296347-fanlvxqs	778	5	,	,	,
cord-296347-fanlvxqs	778	6	2004	2004	CD
cord-296347-fanlvxqs	778	7	)	)	-RRB-
cord-296347-fanlvxqs	778	8	.	.	.
cord-296347-fanlvxqs	779	1	Nef	Nef	NNP
cord-296347-fanlvxqs	779	2	has	have	VBZ
cord-296347-fanlvxqs	779	3	a	a	DT
cord-296347-fanlvxqs	779	4	preference	preference	NN
cord-296347-fanlvxqs	779	5	for	for	IN
cord-296347-fanlvxqs	779	6	AP-1	AP-1	NNP
cord-296347-fanlvxqs	779	7	and	and	CC
cord-296347-fanlvxqs	779	8	AP-3	AP-3	NNP
cord-296347-fanlvxqs	779	9	complexes	complex	NNS
cord-296347-fanlvxqs	780	1	in	in	IN
cord-296347-fanlvxqs	780	2	vitro	vitro	FW
cord-296347-fanlvxqs	781	1	(	(	-LRB-
cord-296347-fanlvxqs	781	2	Janvier	Janvier	NNP
cord-296347-fanlvxqs	781	3	et	et	NNP
cord-296347-fanlvxqs	781	4	al	al	NNP
cord-296347-fanlvxqs	781	5	.	.	NNP
cord-296347-fanlvxqs	781	6	,	,	,
cord-296347-fanlvxqs	781	7	2003b	2003b	CD
cord-296347-fanlvxqs	781	8	)	)	-RRB-
cord-296347-fanlvxqs	781	9	,	,	,
cord-296347-fanlvxqs	781	10	suggesting	suggest	VBG
cord-296347-fanlvxqs	781	11	that	that	IN
cord-296347-fanlvxqs	781	12	the	the	DT
cord-296347-fanlvxqs	781	13	Nef	Nef	NNP
cord-296347-fanlvxqs	781	14	modus	modus	NN
cord-296347-fanlvxqs	781	15	operandi	operandi	NN
cord-296347-fanlvxqs	781	16	is	be	VBZ
cord-296347-fanlvxqs	781	17	mostly	mostly	RB
cord-296347-fanlvxqs	781	18	at	at	IN
cord-296347-fanlvxqs	781	19	the	the	DT
cord-296347-fanlvxqs	781	20	level	level	NN
cord-296347-fanlvxqs	781	21	of	of	IN
cord-296347-fanlvxqs	781	22	endosomal	endosomal	JJ
cord-296347-fanlvxqs	781	23	membranes	membrane	NNS
cord-296347-fanlvxqs	781	24	.	.	.
cord-296347-fanlvxqs	782	1	Downregulation	Downregulation	NNP
cord-296347-fanlvxqs	782	2	from	from	IN
cord-296347-fanlvxqs	782	3	the	the	DT
cord-296347-fanlvxqs	782	4	cell	cell	NN
cord-296347-fanlvxqs	782	5	surface	surface	NN
cord-296347-fanlvxqs	782	6	by	by	IN
cord-296347-fanlvxqs	782	7	binding	bind	VBG
cord-296347-fanlvxqs	782	8	AP-2	AP-2	NNP
cord-296347-fanlvxqs	782	9	does	do	VBZ
cord-296347-fanlvxqs	782	10	not	not	RB
cord-296347-fanlvxqs	782	11	seem	seem	VB
cord-296347-fanlvxqs	782	12	to	to	TO
cord-296347-fanlvxqs	782	13	be	be	VB
cord-296347-fanlvxqs	782	14	a	a	DT
cord-296347-fanlvxqs	782	15	major	major	JJ
cord-296347-fanlvxqs	782	16	route	route	NN
cord-296347-fanlvxqs	782	17	for	for	IN
cord-296347-fanlvxqs	782	18	CD4	CD4	NNP
cord-296347-fanlvxqs	782	19	downregulation	downregulation	NN
cord-296347-fanlvxqs	782	20	(	(	-LRB-
cord-296347-fanlvxqs	782	21	Rose	Rose	NNP
cord-296347-fanlvxqs	782	22	et	et	FW
cord-296347-fanlvxqs	782	23	al	al	NNP
cord-296347-fanlvxqs	782	24	.	.	NNP
cord-296347-fanlvxqs	782	25	,	,	,
cord-296347-fanlvxqs	782	26	2005	2005	CD
cord-296347-fanlvxqs	782	27	)	)	-RRB-
cord-296347-fanlvxqs	782	28	.	.	.
cord-296347-fanlvxqs	783	1	Which	which	WDT
cord-296347-fanlvxqs	783	2	one	one	CD
cord-296347-fanlvxqs	783	3	of	of	IN
cord-296347-fanlvxqs	783	4	these	these	DT
cord-296347-fanlvxqs	783	5	strategies	strategy	NNS
cord-296347-fanlvxqs	783	6	-	-	:
cord-296347-fanlvxqs	783	7	downregulation	downregulation	NN
cord-296347-fanlvxqs	783	8	from	from	IN
cord-296347-fanlvxqs	783	9	the	the	DT
cord-296347-fanlvxqs	783	10	cell	cell	NN
cord-296347-fanlvxqs	783	11	surface	surface	NN
cord-296347-fanlvxqs	783	12	or	or	CC
cord-296347-fanlvxqs	783	13	intracellular	intracellular	JJ
cord-296347-fanlvxqs	783	14	retention	retention	NN
cord-296347-fanlvxqs	783	15	-	-	:
cord-296347-fanlvxqs	783	16	or	or	CC
cord-296347-fanlvxqs	783	17	what	what	WDT
cord-296347-fanlvxqs	783	18	combinations	combination	NNS
cord-296347-fanlvxqs	783	19	of	of	IN
cord-296347-fanlvxqs	783	20	these	these	DT
cord-296347-fanlvxqs	783	21	strategies	strategy	NNS
cord-296347-fanlvxqs	783	22	and	and	CC
cord-296347-fanlvxqs	783	23	adaptor	adaptor	NN
cord-296347-fanlvxqs	783	24	protein	protein	NN
cord-296347-fanlvxqs	783	25	complexes	complex	NNS
cord-296347-fanlvxqs	783	26	are	be	VBP
cord-296347-fanlvxqs	783	27	used	use	VBN
cord-296347-fanlvxqs	783	28	may	may	MD
cord-296347-fanlvxqs	783	29	allow	allow	VB
cord-296347-fanlvxqs	783	30	the	the	DT
cord-296347-fanlvxqs	783	31	HIV-1	HIV-1	NNP
cord-296347-fanlvxqs	783	32	Nef	Nef	NNP
cord-296347-fanlvxqs	783	33	protein	protein	NN
cord-296347-fanlvxqs	783	34	to	to	TO
cord-296347-fanlvxqs	783	35	downregulate	downregulate	VB
cord-296347-fanlvxqs	783	36	cell	cell	NN
cord-296347-fanlvxqs	783	37	surface	surface	NN
cord-296347-fanlvxqs	783	38	expression	expression	NN
cord-296347-fanlvxqs	783	39	of	of	IN
cord-296347-fanlvxqs	783	40	CD4	CD4	NNP
cord-296347-fanlvxqs	783	41	perhaps	perhaps	RB
cord-296347-fanlvxqs	783	42	in	in	IN
cord-296347-fanlvxqs	783	43	different	different	JJ
cord-296347-fanlvxqs	783	44	cell	cell	NN
cord-296347-fanlvxqs	783	45	types	type	NNS
cord-296347-fanlvxqs	783	46	(	(	-LRB-
cord-296347-fanlvxqs	783	47	Mangasarian	Mangasarian	NNP
cord-296347-fanlvxqs	783	48	and	and	CC
cord-296347-fanlvxqs	783	49	Trono	Trono	NNP
cord-296347-fanlvxqs	783	50	,	,	,
cord-296347-fanlvxqs	783	51	1997	1997	CD
cord-296347-fanlvxqs	783	52	)	)	-RRB-
cord-296347-fanlvxqs	783	53	.	.	.
cord-296347-fanlvxqs	784	1	Vpu	Vpu	NNS
cord-296347-fanlvxqs	784	2	targets	target	NNS
cord-296347-fanlvxqs	784	3	newly	newly	RB
cord-296347-fanlvxqs	784	4	synthesized	synthesize	VBN
cord-296347-fanlvxqs	784	5	CD4	CD4	NNP
cord-296347-fanlvxqs	784	6	molecules	molecule	NNS
cord-296347-fanlvxqs	784	7	in	in	IN
cord-296347-fanlvxqs	784	8	the	the	DT
cord-296347-fanlvxqs	784	9	ER	ER	NNP
cord-296347-fanlvxqs	784	10	for	for	IN
cord-296347-fanlvxqs	784	11	proteasomal	proteasomal	JJ
cord-296347-fanlvxqs	784	12	degradation	degradation	NN
cord-296347-fanlvxqs	784	13	(	(	-LRB-
cord-296347-fanlvxqs	784	14	Kerkau	Kerkau	NNP
cord-296347-fanlvxqs	784	15	et	et	FW
cord-296347-fanlvxqs	784	16	al	al	NNP
cord-296347-fanlvxqs	784	17	.	.	NNP
cord-296347-fanlvxqs	784	18	,	,	,
cord-296347-fanlvxqs	784	19	1997	1997	CD
cord-296347-fanlvxqs	784	20	)	)	-RRB-
cord-296347-fanlvxqs	784	21	by	by	IN
cord-296347-fanlvxqs	784	22	recruiting	recruit	VBG
cord-296347-fanlvxqs	784	23	the	the	DT
cord-296347-fanlvxqs	784	24	cytosolic	cytosolic	JJ
cord-296347-fanlvxqs	784	25	F	F	NNP
cord-296347-fanlvxqs	784	26	-	-	HYPH
cord-296347-fanlvxqs	784	27	box	box	NNP
cord-296347-fanlvxqs	784	28	protein	protein	NN
cord-296347-fanlvxqs	784	29	b	b	NNP
cord-296347-fanlvxqs	784	30	-	-	:
cord-296347-fanlvxqs	784	31	TrCP	TrCP	NNP
cord-296347-fanlvxqs	784	32	,	,	,
cord-296347-fanlvxqs	784	33	the	the	DT
cord-296347-fanlvxqs	784	34	receptor	receptor	NN
cord-296347-fanlvxqs	784	35	component	component	NN
cord-296347-fanlvxqs	784	36	of	of	IN
cord-296347-fanlvxqs	784	37	the	the	DT
cord-296347-fanlvxqs	784	38	SCF	SCF	NNP
cord-296347-fanlvxqs	784	39	b	b	NNP
cord-296347-fanlvxqs	784	40	-	-	:
cord-296347-fanlvxqs	784	41	TrCP	TrCP	NNP
cord-296347-fanlvxqs	784	42	E3	e3	NN
cord-296347-fanlvxqs	784	43	ligase	ligase	NN
cord-296347-fanlvxqs	784	44	,	,	,
cord-296347-fanlvxqs	784	45	to	to	IN
cord-296347-fanlvxqs	784	46	the	the	DT
cord-296347-fanlvxqs	784	47	ER	ER	NNP
cord-296347-fanlvxqs	784	48	membrane	membrane	NN
cord-296347-fanlvxqs	784	49	(	(	-LRB-
cord-296347-fanlvxqs	784	50	Margottin	Margottin	NNP
cord-296347-fanlvxqs	784	51	et	et	NNP
cord-296347-fanlvxqs	784	52	al	al	NNP
cord-296347-fanlvxqs	784	53	.	.	NNP
cord-296347-fanlvxqs	784	54	,	,	,
cord-296347-fanlvxqs	784	55	1998	1998	CD
cord-296347-fanlvxqs	784	56	)	)	-RRB-
cord-296347-fanlvxqs	784	57	.	.	.
cord-296347-fanlvxqs	785	1	A	a	DT
cord-296347-fanlvxqs	785	2	motif	motif	NN
cord-296347-fanlvxqs	785	3	in	in	IN
cord-296347-fanlvxqs	785	4	the	the	DT
cord-296347-fanlvxqs	785	5	Vpu	Vpu	NNP
cord-296347-fanlvxqs	785	6	C	C	NNP
cord-296347-fanlvxqs	785	7	-	-	HYPH
cord-296347-fanlvxqs	785	8	terminus	terminus	NN
cord-296347-fanlvxqs	785	9	binds	bind	VBZ
cord-296347-fanlvxqs	785	10	a	a	DT
cord-296347-fanlvxqs	785	11	WD	WD	NNP
cord-296347-fanlvxqs	785	12	repeat	repeat	NN
cord-296347-fanlvxqs	785	13	on	on	IN
cord-296347-fanlvxqs	785	14	b	b	NN
cord-296347-fanlvxqs	785	15	-	-	:
cord-296347-fanlvxqs	785	16	TrCP	trcp	NN
cord-296347-fanlvxqs	785	17	,	,	,
cord-296347-fanlvxqs	785	18	directing	direct	VBG
cord-296347-fanlvxqs	785	19	SCF	SCF	NNP
cord-296347-fanlvxqs	785	20	b	b	NNP
cord-296347-fanlvxqs	785	21	-	-	:
cord-296347-fanlvxqs	785	22	TrCP	TrCP	NNP
cord-296347-fanlvxqs	785	23	E3	e3	NN
cord-296347-fanlvxqs	785	24	ligase	ligase	NN
cord-296347-fanlvxqs	785	25	activity	activity	NN
cord-296347-fanlvxqs	785	26	to	to	TO
cord-296347-fanlvxqs	785	27	catalyze	catalyze	VB
cord-296347-fanlvxqs	785	28	the	the	DT
cord-296347-fanlvxqs	785	29	ubiquitination	ubiquitination	NN
cord-296347-fanlvxqs	785	30	of	of	IN
cord-296347-fanlvxqs	785	31	lysine	lysine	NN
cord-296347-fanlvxqs	785	32	residues	residue	NNS
cord-296347-fanlvxqs	785	33	on	on	IN
cord-296347-fanlvxqs	785	34	the	the	DT
cord-296347-fanlvxqs	785	35	CD4	CD4	NNP
cord-296347-fanlvxqs	785	36	tail	tail	NN
cord-296347-fanlvxqs	785	37	,	,	,
cord-296347-fanlvxqs	785	38	which	which	WDT
cord-296347-fanlvxqs	785	39	serves	serve	VBZ
cord-296347-fanlvxqs	785	40	as	as	IN
cord-296347-fanlvxqs	785	41	the	the	DT
cord-296347-fanlvxqs	785	42	trigger	trigger	NN
cord-296347-fanlvxqs	785	43	for	for	IN
cord-296347-fanlvxqs	785	44	CD4	CD4	NNP
cord-296347-fanlvxqs	785	45	degradation	degradation	NN
cord-296347-fanlvxqs	786	1	(	(	-LRB-
cord-296347-fanlvxqs	786	2	Margottin	Margottin	NNP
cord-296347-fanlvxqs	786	3	et	et	NNP
cord-296347-fanlvxqs	786	4	al	al	NNP
cord-296347-fanlvxqs	786	5	.	.	NNP
cord-296347-fanlvxqs	786	6	,	,	,
cord-296347-fanlvxqs	786	7	1998	1998	CD
cord-296347-fanlvxqs	786	8	;	;	:
cord-296347-fanlvxqs	786	9	Schubert	Schubert	NNP
cord-296347-fanlvxqs	786	10	et	et	NNP
cord-296347-fanlvxqs	786	11	al	al	NNP
cord-296347-fanlvxqs	786	12	.	.	NNP
cord-296347-fanlvxqs	786	13	,	,	,
cord-296347-fanlvxqs	786	14	1998	1998	CD
cord-296347-fanlvxqs	786	15	)	)	-RRB-
cord-296347-fanlvxqs	786	16	.	.	.
cord-296347-fanlvxqs	787	1	gp160	gp160	NNP
cord-296347-fanlvxqs	787	2	retains	retain	VBZ
cord-296347-fanlvxqs	787	3	newly	newly	RB
cord-296347-fanlvxqs	787	4	synthesized	synthesize	VBN
cord-296347-fanlvxqs	787	5	CD4	CD4	NNP
cord-296347-fanlvxqs	787	6	molecules	molecule	NNS
cord-296347-fanlvxqs	787	7	in	in	IN
cord-296347-fanlvxqs	787	8	the	the	DT
cord-296347-fanlvxqs	787	9	ER	ER	NNP
cord-296347-fanlvxqs	787	10	(	(	-LRB-
cord-296347-fanlvxqs	787	11	Crise	Crise	NNP
cord-296347-fanlvxqs	787	12	and	and	CC
cord-296347-fanlvxqs	787	13	Rose	Rose	NNP
cord-296347-fanlvxqs	787	14	,	,	,
cord-296347-fanlvxqs	787	15	1992	1992	CD
cord-296347-fanlvxqs	787	16	;	;	.
cord-296347-fanlvxqs	788	1	Kimura	Kimura	NNP
cord-296347-fanlvxqs	788	2	et	et	FW
cord-296347-fanlvxqs	788	3	al	al	NNP
cord-296347-fanlvxqs	788	4	.	.	NNP
cord-296347-fanlvxqs	788	5	,	,	,
cord-296347-fanlvxqs	788	6	1994	1994	CD
cord-296347-fanlvxqs	788	7	)	)	-RRB-
cord-296347-fanlvxqs	788	8	.	.	.
cord-296347-fanlvxqs	789	1	In	in	IN
cord-296347-fanlvxqs	789	2	the	the	DT
cord-296347-fanlvxqs	789	3	absence	absence	NN
cord-296347-fanlvxqs	789	4	of	of	IN
cord-296347-fanlvxqs	789	5	CD4	CD4	NNP
cord-296347-fanlvxqs	789	6	,	,	,
cord-296347-fanlvxqs	789	7	HIV	HIV	NNP
cord-296347-fanlvxqs	789	8	gp160	gp160	NNP
cord-296347-fanlvxqs	789	9	is	be	VBZ
cord-296347-fanlvxqs	789	10	posttranslationally	posttranslationally	RB
cord-296347-fanlvxqs	789	11	cleaved	cleave	VBN
cord-296347-fanlvxqs	789	12	into	into	IN
cord-296347-fanlvxqs	789	13	its	-PRON-	PRP$
cord-296347-fanlvxqs	789	14	gp120	gp120	NNP
cord-296347-fanlvxqs	789	15	and	and	CC
cord-296347-fanlvxqs	789	16	gp41	gp41	NNP
cord-296347-fanlvxqs	789	17	subunits	subunit	NNS
cord-296347-fanlvxqs	789	18	at	at	IN
cord-296347-fanlvxqs	789	19	the	the	DT
cord-296347-fanlvxqs	789	20	level	level	NN
cord-296347-fanlvxqs	789	21	of	of	IN
cord-296347-fanlvxqs	789	22	the	the	DT
cord-296347-fanlvxqs	789	23	ER	er	NN
cord-296347-fanlvxqs	789	24	-	-	HYPH
cord-296347-fanlvxqs	789	25	to	to	IN
cord-296347-fanlvxqs	789	26	-	-	HYPH
cord-296347-fanlvxqs	789	27	Golgi	golgi	NN
cord-296347-fanlvxqs	789	28	compartment	compartment	NN
cord-296347-fanlvxqs	789	29	(	(	-LRB-
cord-296347-fanlvxqs	789	30	ERGIC	ERGIC	NNP
cord-296347-fanlvxqs	789	31	)	)	-RRB-
cord-296347-fanlvxqs	789	32	.	.	.
cord-296347-fanlvxqs	790	1	In	in	IN
cord-296347-fanlvxqs	790	2	the	the	DT
cord-296347-fanlvxqs	790	3	presence	presence	NN
cord-296347-fanlvxqs	790	4	of	of	IN
cord-296347-fanlvxqs	790	5	CD4	CD4	NNP
cord-296347-fanlvxqs	790	6	,	,	,
cord-296347-fanlvxqs	790	7	gp160	gp160	NNP
cord-296347-fanlvxqs	790	8	forms	form	VBZ
cord-296347-fanlvxqs	790	9	a	a	DT
cord-296347-fanlvxqs	790	10	complex	complex	NN
cord-296347-fanlvxqs	790	11	with	with	IN
cord-296347-fanlvxqs	790	12	CD4	CD4	NNP
cord-296347-fanlvxqs	790	13	that	that	WDT
cord-296347-fanlvxqs	790	14	mediates	mediate	VBZ
cord-296347-fanlvxqs	790	15	ER	ER	NNP
cord-296347-fanlvxqs	790	16	retention	retention	NN
cord-296347-fanlvxqs	790	17	of	of	IN
cord-296347-fanlvxqs	790	18	both	both	DT
cord-296347-fanlvxqs	790	19	molecules	molecule	NNS
cord-296347-fanlvxqs	790	20	and	and	CC
cord-296347-fanlvxqs	790	21	downregulation	downregulation	NN
cord-296347-fanlvxqs	790	22	of	of	IN
cord-296347-fanlvxqs	790	23	CD4	CD4	NNP
cord-296347-fanlvxqs	790	24	from	from	IN
cord-296347-fanlvxqs	790	25	the	the	DT
cord-296347-fanlvxqs	790	26	cell	cell	NN
cord-296347-fanlvxqs	790	27	surface	surface	NN
cord-296347-fanlvxqs	790	28	.	.	.
cord-296347-fanlvxqs	791	1	In	in	IN
cord-296347-fanlvxqs	791	2	the	the	DT
cord-296347-fanlvxqs	791	3	context	context	NN
cord-296347-fanlvxqs	791	4	of	of	IN
cord-296347-fanlvxqs	791	5	an	an	DT
cord-296347-fanlvxqs	791	6	HIV	HIV	NNP
cord-296347-fanlvxqs	791	7	-	-	HYPH
cord-296347-fanlvxqs	791	8	infected	infect	VBN
cord-296347-fanlvxqs	791	9	cell	cell	NN
cord-296347-fanlvxqs	791	10	,	,	,
cord-296347-fanlvxqs	791	11	coexpression	coexpression	NN
cord-296347-fanlvxqs	791	12	of	of	IN
cord-296347-fanlvxqs	791	13	Vpu	Vpu	NNP
cord-296347-fanlvxqs	791	14	liberates	liberate	VBZ
cord-296347-fanlvxqs	791	15	gp160	gp160	NN
cord-296347-fanlvxqs	791	16	from	from	IN
cord-296347-fanlvxqs	791	17	the	the	DT
cord-296347-fanlvxqs	791	18	complex	complex	NN
cord-296347-fanlvxqs	791	19	,	,	,
cord-296347-fanlvxqs	791	20	ensuring	ensure	VBG
cord-296347-fanlvxqs	791	21	gp160	gp160	NNP
cord-296347-fanlvxqs	791	22	translocation	translocation	NN
cord-296347-fanlvxqs	791	23	to	to	IN
cord-296347-fanlvxqs	791	24	the	the	DT
cord-296347-fanlvxqs	791	25	ERGIC	ERGIC	NNP
cord-296347-fanlvxqs	791	26	and	and	CC
cord-296347-fanlvxqs	791	27	ensuing	ensue	VBG
cord-296347-fanlvxqs	791	28	maturation	maturation	NN
cord-296347-fanlvxqs	791	29	,	,	,
cord-296347-fanlvxqs	791	30	and	and	CC
cord-296347-fanlvxqs	791	31	simultaneously	simultaneously	RB
cord-296347-fanlvxqs	791	32	accelerating	accelerate	VBG
cord-296347-fanlvxqs	791	33	CD4	CD4	NNP
cord-296347-fanlvxqs	791	34	turnover	turnover	NN
cord-296347-fanlvxqs	791	35	(	(	-LRB-
cord-296347-fanlvxqs	791	36	Crise	Crise	NNP
cord-296347-fanlvxqs	791	37	and	and	CC
cord-296347-fanlvxqs	791	38	Rose	Rose	NNP
cord-296347-fanlvxqs	791	39	,	,	,
cord-296347-fanlvxqs	791	40	1992	1992	CD
cord-296347-fanlvxqs	791	41	;	;	.
cord-296347-fanlvxqs	792	1	Rose	Rose	NNP
cord-296347-fanlvxqs	792	2	et	et	FW
cord-296347-fanlvxqs	792	3	al	al	NNP
cord-296347-fanlvxqs	792	4	.	.	NNP
cord-296347-fanlvxqs	792	5	,	,	,
cord-296347-fanlvxqs	792	6	2005	2005	CD
cord-296347-fanlvxqs	792	7	)	)	-RRB-
cord-296347-fanlvxqs	792	8	.	.	.
cord-296347-fanlvxqs	793	1	HIV	HIV	NNP
cord-296347-fanlvxqs	793	2	downregulates	downregulate	VBZ
cord-296347-fanlvxqs	793	3	class	class	NN
cord-296347-fanlvxqs	793	4	I	-PRON-	PRP
cord-296347-fanlvxqs	793	5	MHC	MHC	NNP
cord-296347-fanlvxqs	793	6	,	,	,
cord-296347-fanlvxqs	793	7	class	class	NN
cord-296347-fanlvxqs	793	8	II	II	NNP
cord-296347-fanlvxqs	793	9	MHC	MHC	NNP
cord-296347-fanlvxqs	793	10	,	,	,
cord-296347-fanlvxqs	793	11	CD4	CD4	NNP
cord-296347-fanlvxqs	793	12	,	,	,
cord-296347-fanlvxqs	793	13	and	and	CC
cord-296347-fanlvxqs	793	14	CD1d	CD1d	NNP
cord-296347-fanlvxqs	793	15	,	,	,
cord-296347-fanlvxqs	793	16	a	a	DT
cord-296347-fanlvxqs	793	17	class	class	NN
cord-296347-fanlvxqs	793	18	I	-PRON-	PRP
cord-296347-fanlvxqs	793	19	MHC	MHC	NNP
cord-296347-fanlvxqs	793	20	-	-	HYPH
cord-296347-fanlvxqs	793	21	like	like	JJ
cord-296347-fanlvxqs	793	22	molecule	molecule	NN
cord-296347-fanlvxqs	793	23	that	that	WDT
cord-296347-fanlvxqs	793	24	presents	present	VBZ
cord-296347-fanlvxqs	793	25	lipid	lipid	NN
cord-296347-fanlvxqs	793	26	antigens	antigen	NNS
cord-296347-fanlvxqs	793	27	(	(	-LRB-
cord-296347-fanlvxqs	793	28	Le	Le	NNP
cord-296347-fanlvxqs	793	29	Gall	Gall	NNP
cord-296347-fanlvxqs	793	30	et	et	FW
cord-296347-fanlvxqs	793	31	al	al	NNP
cord-296347-fanlvxqs	793	32	.	.	NNP
cord-296347-fanlvxqs	793	33	,	,	,
cord-296347-fanlvxqs	793	34	1998	1998	CD
cord-296347-fanlvxqs	793	35	;	;	:
cord-296347-fanlvxqs	794	1	Piguet	Piguet	NNP
cord-296347-fanlvxqs	794	2	et	et	NNP
cord-296347-fanlvxqs	794	3	al	al	NNP
cord-296347-fanlvxqs	794	4	.	.	.
cord-296347-fanlvxqs	795	1	,	,	,
cord-296347-fanlvxqs	795	2	1999b	1999b	CD
cord-296347-fanlvxqs	795	3	)	)	-RRB-
cord-296347-fanlvxqs	795	4	,	,	,
cord-296347-fanlvxqs	795	5	from	from	IN
cord-296347-fanlvxqs	795	6	the	the	DT
cord-296347-fanlvxqs	795	7	cell	cell	NN
cord-296347-fanlvxqs	795	8	surface	surface	NN
cord-296347-fanlvxqs	795	9	by	by	IN
cord-296347-fanlvxqs	795	10	virtue	virtue	NN
cord-296347-fanlvxqs	795	11	of	of	IN
cord-296347-fanlvxqs	795	12	its	-PRON-	PRP$
cord-296347-fanlvxqs	795	13	Nef	Nef	NNP
cord-296347-fanlvxqs	795	14	,	,	,
cord-296347-fanlvxqs	795	15	Vpu	Vpu	NNP
cord-296347-fanlvxqs	795	16	,	,	,
cord-296347-fanlvxqs	795	17	and	and	CC
cord-296347-fanlvxqs	795	18	gp160	gp160	NN
cord-296347-fanlvxqs	795	19	proteins	protein	NNS
cord-296347-fanlvxqs	795	20	,	,	,
cord-296347-fanlvxqs	795	21	reflecting	reflect	VBG
cord-296347-fanlvxqs	795	22	its	-PRON-	PRP$
cord-296347-fanlvxqs	795	23	ability	ability	NN
cord-296347-fanlvxqs	795	24	to	to	TO
cord-296347-fanlvxqs	795	25	manipulate	manipulate	VB
cord-296347-fanlvxqs	795	26	various	various	JJ
cord-296347-fanlvxqs	795	27	aspects	aspect	NNS
cord-296347-fanlvxqs	795	28	of	of	IN
cord-296347-fanlvxqs	795	29	the	the	DT
cord-296347-fanlvxqs	795	30	immune	immune	JJ
cord-296347-fanlvxqs	795	31	response	response	NN
cord-296347-fanlvxqs	795	32	(	(	-LRB-
cord-296347-fanlvxqs	795	33	Joseph	Joseph	NNP
cord-296347-fanlvxqs	795	34	et	et	NNP
cord-296347-fanlvxqs	795	35	al	al	NNP
cord-296347-fanlvxqs	795	36	.	.	NNP
cord-296347-fanlvxqs	795	37	,	,	,
cord-296347-fanlvxqs	795	38	2005	2005	CD
cord-296347-fanlvxqs	795	39	;	;	:
cord-296347-fanlvxqs	795	40	Piguet	Piguet	NNP
cord-296347-fanlvxqs	795	41	et	et	NNP
cord-296347-fanlvxqs	795	42	al	al	NNP
cord-296347-fanlvxqs	795	43	.	.	NNP
cord-296347-fanlvxqs	795	44	,	,	,
cord-296347-fanlvxqs	795	45	1999b	1999b	CD
cord-296347-fanlvxqs	795	46	)	)	-RRB-
cord-296347-fanlvxqs	795	47	.	.	.
cord-296347-fanlvxqs	796	1	Furthermore	furthermore	RB
cord-296347-fanlvxqs	796	2	,	,	,
cord-296347-fanlvxqs	796	3	each	each	DT
cord-296347-fanlvxqs	796	4	of	of	IN
cord-296347-fanlvxqs	796	5	these	these	DT
cord-296347-fanlvxqs	796	6	mechanisms	mechanism	NNS
cord-296347-fanlvxqs	796	7	may	may	MD
cord-296347-fanlvxqs	796	8	be	be	VB
cord-296347-fanlvxqs	796	9	more	more	RBR
cord-296347-fanlvxqs	796	10	far	far	RB
cord-296347-fanlvxqs	796	11	-	-	HYPH
cord-296347-fanlvxqs	796	12	reaching	reach	VBG
cord-296347-fanlvxqs	796	13	than	than	IN
cord-296347-fanlvxqs	796	14	downregulation	downregulation	NN
cord-296347-fanlvxqs	796	15	of	of	IN
cord-296347-fanlvxqs	796	16	each	each	DT
cord-296347-fanlvxqs	796	17	individual	individual	JJ
cord-296347-fanlvxqs	796	18	receptor	receptor	NN
cord-296347-fanlvxqs	796	19	.	.	.
cord-296347-fanlvxqs	797	1	For	for	IN
cord-296347-fanlvxqs	797	2	instance	instance	NN
cord-296347-fanlvxqs	797	3	,	,	,
cord-296347-fanlvxqs	797	4	by	by	IN
cord-296347-fanlvxqs	797	5	directly	directly	RB
cord-296347-fanlvxqs	797	6	associating	associate	VBG
cord-296347-fanlvxqs	797	7	with	with	IN
cord-296347-fanlvxqs	797	8	the	the	DT
cord-296347-fanlvxqs	797	9	proton	proton	NN
cord-296347-fanlvxqs	797	10	(	(	-LRB-
cord-296347-fanlvxqs	798	1	H	H	NNP
cord-296347-fanlvxqs	798	2	þ	þ	NNP
cord-296347-fanlvxqs	798	3	)	)	-RRB-
cord-296347-fanlvxqs	798	4	ATPase	ATPase	NNP
cord-296347-fanlvxqs	798	5	,	,	,
cord-296347-fanlvxqs	798	6	which	which	WDT
cord-296347-fanlvxqs	798	7	is	be	VBZ
cord-296347-fanlvxqs	798	8	required	require	VBN
cord-296347-fanlvxqs	798	9	for	for	IN
cord-296347-fanlvxqs	798	10	the	the	DT
cord-296347-fanlvxqs	798	11	acidification	acidification	NN
cord-296347-fanlvxqs	798	12	of	of	IN
cord-296347-fanlvxqs	798	13	lysosomes	lysosome	NNS
cord-296347-fanlvxqs	798	14	,	,	,
cord-296347-fanlvxqs	798	15	Nef	Nef	NNP
cord-296347-fanlvxqs	798	16	not	not	RB
cord-296347-fanlvxqs	798	17	only	only	RB
cord-296347-fanlvxqs	798	18	downregulates	downregulate	VBZ
cord-296347-fanlvxqs	798	19	CD4	CD4	NNP
cord-296347-fanlvxqs	798	20	but	but	CC
cord-296347-fanlvxqs	798	21	may	may	MD
cord-296347-fanlvxqs	798	22	also	also	RB
cord-296347-fanlvxqs	798	23	interfere	interfere	VB
cord-296347-fanlvxqs	798	24	with	with	IN
cord-296347-fanlvxqs	798	25	the	the	DT
cord-296347-fanlvxqs	798	26	pH	pH	NNP
cord-296347-fanlvxqs	798	27	of	of	IN
cord-296347-fanlvxqs	798	28	class	class	NNP
cord-296347-fanlvxqs	798	29	II	II	NNP
cord-296347-fanlvxqs	798	30	MHC	MHC	NNP
cord-296347-fanlvxqs	798	31	-	-	HYPH
cord-296347-fanlvxqs	798	32	positive	positive	JJ
cord-296347-fanlvxqs	798	33	compartments	compartment	NNS
cord-296347-fanlvxqs	798	34	,	,	,
cord-296347-fanlvxqs	798	35	affecting	affect	VBG
cord-296347-fanlvxqs	798	36	antigen	antigen	NN
cord-296347-fanlvxqs	798	37	processing	processing	NN
cord-296347-fanlvxqs	798	38	by	by	IN
cord-296347-fanlvxqs	798	39	lysosomal	lysosomal	JJ
cord-296347-fanlvxqs	798	40	proteases	protease	NNS
cord-296347-fanlvxqs	798	41	and	and	CC
cord-296347-fanlvxqs	798	42	class	class	NN
cord-296347-fanlvxqs	798	43	II	II	NNP
cord-296347-fanlvxqs	798	44	MHC	MHC	NNP
cord-296347-fanlvxqs	798	45	antigen	antigen	NN
cord-296347-fanlvxqs	798	46	presentation	presentation	NN
cord-296347-fanlvxqs	798	47	.	.	.
cord-296347-fanlvxqs	799	1	This	this	DT
cord-296347-fanlvxqs	799	2	strategy	strategy	NN
cord-296347-fanlvxqs	799	3	is	be	VBZ
cord-296347-fanlvxqs	799	4	used	use	VBN
cord-296347-fanlvxqs	799	5	by	by	IN
cord-296347-fanlvxqs	799	6	other	other	JJ
cord-296347-fanlvxqs	799	7	pathogens	pathogen	NNS
cord-296347-fanlvxqs	799	8	:	:	:
cord-296347-fanlvxqs	799	9	the	the	DT
cord-296347-fanlvxqs	799	10	E5	E5	NNP
cord-296347-fanlvxqs	799	11	protein	protein	NN
cord-296347-fanlvxqs	799	12	from	from	IN
cord-296347-fanlvxqs	799	13	both	both	CC
cord-296347-fanlvxqs	799	14	human	human	JJ
cord-296347-fanlvxqs	799	15	and	and	CC
cord-296347-fanlvxqs	799	16	bovine	bovine	JJ
cord-296347-fanlvxqs	799	17	papillomavirus	papillomavirus	NN
cord-296347-fanlvxqs	800	1	(	(	-LRB-
cord-296347-fanlvxqs	800	2	Andresson	Andresson	NNP
cord-296347-fanlvxqs	800	3	et	et	NNP
cord-296347-fanlvxqs	800	4	al	al	NNP
cord-296347-fanlvxqs	800	5	.	.	NNP
cord-296347-fanlvxqs	800	6	,	,	,
cord-296347-fanlvxqs	800	7	1995	1995	CD
cord-296347-fanlvxqs	800	8	)	)	-RRB-
cord-296347-fanlvxqs	800	9	and	and	CC
cord-296347-fanlvxqs	800	10	the	the	DT
cord-296347-fanlvxqs	800	11	VacA	VacA	NNP
cord-296347-fanlvxqs	800	12	toxin	toxin	NN
cord-296347-fanlvxqs	800	13	secreted	secrete	VBN
cord-296347-fanlvxqs	800	14	by	by	IN
cord-296347-fanlvxqs	800	15	Helicobacter	Helicobacter	NNP
cord-296347-fanlvxqs	800	16	pylori	pylori	NN
cord-296347-fanlvxqs	801	1	(	(	-LRB-
cord-296347-fanlvxqs	801	2	Molinari	Molinari	NNP
cord-296347-fanlvxqs	801	3	et	et	NNP
cord-296347-fanlvxqs	801	4	al	al	NNP
cord-296347-fanlvxqs	801	5	.	.	NNP
cord-296347-fanlvxqs	801	6	,	,	,
cord-296347-fanlvxqs	801	7	1998	1998	CD
cord-296347-fanlvxqs	801	8	)	)	-RRB-
cord-296347-fanlvxqs	801	9	actively	actively	RB
cord-296347-fanlvxqs	801	10	manipulate	manipulate	VBP
cord-296347-fanlvxqs	801	11	acidification	acidification	NN
cord-296347-fanlvxqs	801	12	in	in	IN
cord-296347-fanlvxqs	801	13	the	the	DT
cord-296347-fanlvxqs	801	14	endocytic	endocytic	JJ
cord-296347-fanlvxqs	801	15	pathway	pathway	NN
cord-296347-fanlvxqs	801	16	,	,	,
cord-296347-fanlvxqs	801	17	resulting	result	VBG
cord-296347-fanlvxqs	801	18	in	in	IN
cord-296347-fanlvxqs	802	1	impaired	impaired	JJ
cord-296347-fanlvxqs	802	2	CD4	CD4	NNP
cord-296347-fanlvxqs	803	1	þ	þ	NNP
cord-296347-fanlvxqs	803	2	T	T	NNP
cord-296347-fanlvxqs	803	3	cell	cell	NN
cord-296347-fanlvxqs	803	4	-	-	HYPH
cord-296347-fanlvxqs	803	5	mediated	mediate	VBN
cord-296347-fanlvxqs	803	6	responses	response	NNS
cord-296347-fanlvxqs	803	7	(	(	-LRB-
cord-296347-fanlvxqs	803	8	Brodsky	Brodsky	NNP
cord-296347-fanlvxqs	803	9	et	et	NNP
cord-296347-fanlvxqs	803	10	al	al	NNP
cord-296347-fanlvxqs	803	11	.	.	NNP
cord-296347-fanlvxqs	803	12	,	,	,
cord-296347-fanlvxqs	803	13	1999	1999	CD
cord-296347-fanlvxqs	803	14	)	)	-RRB-
cord-296347-fanlvxqs	803	15	.	.	.
cord-296347-fanlvxqs	804	1	By	by	IN
cord-296347-fanlvxqs	804	2	binding	bind	VBG
cord-296347-fanlvxqs	804	3	to	to	IN
cord-296347-fanlvxqs	804	4	AP	AP	NNP
cord-296347-fanlvxqs	804	5	complexes	complex	NNS
cord-296347-fanlvxqs	804	6	or	or	CC
cord-296347-fanlvxqs	804	7	to	to	IN
cord-296347-fanlvxqs	804	8	the	the	DT
cord-296347-fanlvxqs	804	9	small	small	JJ
cord-296347-fanlvxqs	804	10	GTPase	GTPase	NNP
cord-296347-fanlvxqs	804	11	ARF1	ARF1	NNP
cord-296347-fanlvxqs	804	12	,	,	,
cord-296347-fanlvxqs	804	13	Nef	Nef	NNP
cord-296347-fanlvxqs	804	14	may	may	MD
cord-296347-fanlvxqs	804	15	interfere	interfere	VB
cord-296347-fanlvxqs	804	16	with	with	IN
cord-296347-fanlvxqs	804	17	trafficking	trafficking	NN
cord-296347-fanlvxqs	804	18	and	and	CC
cord-296347-fanlvxqs	804	19	alter	alter	VB
cord-296347-fanlvxqs	804	20	the	the	DT
cord-296347-fanlvxqs	804	21	fate	fate	NN
cord-296347-fanlvxqs	804	22	of	of	IN
cord-296347-fanlvxqs	804	23	numerous	numerous	JJ
cord-296347-fanlvxqs	804	24	host	host	NN
cord-296347-fanlvxqs	804	25	molecules	molecule	NNS
cord-296347-fanlvxqs	804	26	in	in	IN
cord-296347-fanlvxqs	804	27	the	the	DT
cord-296347-fanlvxqs	804	28	endocytic	endocytic	JJ
cord-296347-fanlvxqs	804	29	pathway	pathway	NN
cord-296347-fanlvxqs	805	1	(	(	-LRB-
cord-296347-fanlvxqs	805	2	Janvier	Janvier	NNP
cord-296347-fanlvxqs	805	3	et	et	NNP
cord-296347-fanlvxqs	805	4	al	al	NNP
cord-296347-fanlvxqs	805	5	.	.	NNP
cord-296347-fanlvxqs	805	6	,	,	,
cord-296347-fanlvxqs	805	7	2003a	2003a	CD
cord-296347-fanlvxqs	805	8	)	)	-RRB-
cord-296347-fanlvxqs	805	9	,	,	,
cord-296347-fanlvxqs	805	10	affecting	affect	VBG
cord-296347-fanlvxqs	805	11	aspects	aspect	NNS
cord-296347-fanlvxqs	805	12	that	that	WDT
cord-296347-fanlvxqs	805	13	range	range	VBP
cord-296347-fanlvxqs	805	14	from	from	IN
cord-296347-fanlvxqs	805	15	viral	viral	JJ
cord-296347-fanlvxqs	805	16	replication	replication	NN
cord-296347-fanlvxqs	805	17	to	to	IN
cord-296347-fanlvxqs	805	18	modulation	modulation	NN
cord-296347-fanlvxqs	805	19	of	of	IN
cord-296347-fanlvxqs	805	20	the	the	DT
cord-296347-fanlvxqs	805	21	immune	immune	JJ
cord-296347-fanlvxqs	805	22	system	system	NN
cord-296347-fanlvxqs	805	23	(	(	-LRB-
cord-296347-fanlvxqs	805	24	Lama	Lama	NNP
cord-296347-fanlvxqs	805	25	and	and	CC
cord-296347-fanlvxqs	805	26	Ware	Ware	NNP
cord-296347-fanlvxqs	805	27	,	,	,
cord-296347-fanlvxqs	805	28	2000	2000	CD
cord-296347-fanlvxqs	805	29	;	;	:
cord-296347-fanlvxqs	805	30	Sol	Sol	NNP
cord-296347-fanlvxqs	805	31	-	-	HYPH
cord-296347-fanlvxqs	805	32	Foulon	Foulon	NNP
cord-296347-fanlvxqs	805	33	et	et	NNP
cord-296347-fanlvxqs	805	34	al	al	NNP
cord-296347-fanlvxqs	805	35	.	.	.
cord-296347-fanlvxqs	806	1	,	,	,
cord-296347-fanlvxqs	806	2	2002	2002	CD
cord-296347-fanlvxqs	806	3	;	;	:
cord-296347-fanlvxqs	806	4	Swigut	Swigut	NNP
cord-296347-fanlvxqs	806	5	et	et	NNP
cord-296347-fanlvxqs	806	6	al	al	NNP
cord-296347-fanlvxqs	806	7	.	.	NNP
cord-296347-fanlvxqs	806	8	,	,	,
cord-296347-fanlvxqs	806	9	2001	2001	CD
cord-296347-fanlvxqs	806	10	)	)	-RRB-
cord-296347-fanlvxqs	806	11	.	.	.
cord-296347-fanlvxqs	807	1	Intracellular	Intracellular	NNP
cord-296347-fanlvxqs	807	2	pathogens	pathogen	NNS
cord-296347-fanlvxqs	807	3	exploit	exploit	VBP
cord-296347-fanlvxqs	807	4	the	the	DT
cord-296347-fanlvxqs	807	5	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	807	6	-	-	HYPH
cord-296347-fanlvxqs	807	7	proteasome	proteasome	VBN
cord-296347-fanlvxqs	807	8	system	system	NN
cord-296347-fanlvxqs	807	9	mostly	mostly	RB
cord-296347-fanlvxqs	807	10	to	to	TO
cord-296347-fanlvxqs	807	11	destroy	destroy	VB
cord-296347-fanlvxqs	807	12	or	or	CC
cord-296347-fanlvxqs	807	13	avoid	avoid	VB
cord-296347-fanlvxqs	807	14	destruction	destruction	NN
cord-296347-fanlvxqs	807	15	of	of	IN
cord-296347-fanlvxqs	807	16	specific	specific	JJ
cord-296347-fanlvxqs	807	17	cellular	cellular	JJ
cord-296347-fanlvxqs	807	18	proteins	protein	NNS
cord-296347-fanlvxqs	807	19	.	.	.
cord-296347-fanlvxqs	808	1	This	this	DT
cord-296347-fanlvxqs	808	2	serves	serve	VBZ
cord-296347-fanlvxqs	808	3	to	to	TO
cord-296347-fanlvxqs	808	4	create	create	VB
cord-296347-fanlvxqs	808	5	a	a	DT
cord-296347-fanlvxqs	808	6	more	more	RBR
cord-296347-fanlvxqs	808	7	hospitable	hospitable	JJ
cord-296347-fanlvxqs	808	8	environment	environment	NN
cord-296347-fanlvxqs	808	9	for	for	IN
cord-296347-fanlvxqs	808	10	themselves	-PRON-	PRP
cord-296347-fanlvxqs	808	11	in	in	IN
cord-296347-fanlvxqs	808	12	the	the	DT
cord-296347-fanlvxqs	808	13	host	host	NN
cord-296347-fanlvxqs	808	14	cell	cell	NN
cord-296347-fanlvxqs	808	15	,	,	,
cord-296347-fanlvxqs	808	16	or	or	CC
cord-296347-fanlvxqs	808	17	to	to	TO
cord-296347-fanlvxqs	808	18	prevent	prevent	VB
cord-296347-fanlvxqs	808	19	destruction	destruction	NN
cord-296347-fanlvxqs	808	20	of	of	IN
cord-296347-fanlvxqs	808	21	their	-PRON-	PRP$
cord-296347-fanlvxqs	808	22	own	own	JJ
cord-296347-fanlvxqs	808	23	proteins	protein	NNS
cord-296347-fanlvxqs	808	24	,	,	,
cord-296347-fanlvxqs	808	25	and	and	CC
cord-296347-fanlvxqs	808	26	so	so	RB
cord-296347-fanlvxqs	808	27	to	to	TO
cord-296347-fanlvxqs	808	28	ensure	ensure	VB
cord-296347-fanlvxqs	808	29	replication	replication	NN
cord-296347-fanlvxqs	808	30	or	or	CC
cord-296347-fanlvxqs	808	31	avoid	avoid	VB
cord-296347-fanlvxqs	808	32	detection	detection	NN
cord-296347-fanlvxqs	808	33	by	by	IN
cord-296347-fanlvxqs	808	34	the	the	DT
cord-296347-fanlvxqs	808	35	immune	immune	JJ
cord-296347-fanlvxqs	808	36	system	system	NN
cord-296347-fanlvxqs	808	37	.	.	.
cord-296347-fanlvxqs	809	1	Many	many	JJ
cord-296347-fanlvxqs	809	2	events	event	NNS
cord-296347-fanlvxqs	809	3	at	at	IN
cord-296347-fanlvxqs	809	4	the	the	DT
cord-296347-fanlvxqs	809	5	initial	initial	JJ
cord-296347-fanlvxqs	809	6	stage	stage	NN
cord-296347-fanlvxqs	809	7	of	of	IN
cord-296347-fanlvxqs	809	8	infection	infection	NN
cord-296347-fanlvxqs	809	9	,	,	,
cord-296347-fanlvxqs	809	10	entry	entry	NN
cord-296347-fanlvxqs	809	11	into	into	IN
cord-296347-fanlvxqs	809	12	the	the	DT
cord-296347-fanlvxqs	809	13	cell	cell	NN
cord-296347-fanlvxqs	809	14	,	,	,
cord-296347-fanlvxqs	809	15	are	be	VBP
cord-296347-fanlvxqs	809	16	controlled	control	VBN
cord-296347-fanlvxqs	809	17	by	by	IN
cord-296347-fanlvxqs	809	18	signaling	signal	VBG
cord-296347-fanlvxqs	809	19	pathways	pathway	NNS
cord-296347-fanlvxqs	809	20	-	-	,
cord-296347-fanlvxqs	809	21	for	for	IN
cord-296347-fanlvxqs	809	22	instance	instance	NN
cord-296347-fanlvxqs	809	23	,	,	,
cord-296347-fanlvxqs	809	24	those	those	DT
cord-296347-fanlvxqs	809	25	involved	involve	VBN
cord-296347-fanlvxqs	809	26	in	in	IN
cord-296347-fanlvxqs	809	27	cytoskeletal	cytoskeletal	JJ
cord-296347-fanlvxqs	809	28	rearrangements	rearrangement	NNS
cord-296347-fanlvxqs	809	29	or	or	CC
cord-296347-fanlvxqs	809	30	in	in	IN
cord-296347-fanlvxqs	809	31	receptor	receptor	NN
cord-296347-fanlvxqs	809	32	engagement	engagement	NN
cord-296347-fanlvxqs	809	33	-	-	:
cord-296347-fanlvxqs	809	34	that	that	WDT
cord-296347-fanlvxqs	809	35	rely	rely	VBP
cord-296347-fanlvxqs	809	36	heavily	heavily	RB
cord-296347-fanlvxqs	809	37	on	on	IN
cord-296347-fanlvxqs	809	38	the	the	DT
cord-296347-fanlvxqs	809	39	Ub	Ub	NNP
cord-296347-fanlvxqs	809	40	-	-	HYPH
cord-296347-fanlvxqs	809	41	proteasome	proteasome	NN
cord-296347-fanlvxqs	809	42	system	system	NN
cord-296347-fanlvxqs	809	43	.	.	.
cord-296347-fanlvxqs	810	1	The	the	DT
cord-296347-fanlvxqs	810	2	same	same	JJ
cord-296347-fanlvxqs	810	3	is	be	VBZ
cord-296347-fanlvxqs	810	4	true	true	JJ
cord-296347-fanlvxqs	810	5	for	for	IN
cord-296347-fanlvxqs	810	6	signaling	signal	VBG
cord-296347-fanlvxqs	810	7	cascades	cascade	NNS
cord-296347-fanlvxqs	810	8	involved	involve	VBN
cord-296347-fanlvxqs	810	9	in	in	IN
cord-296347-fanlvxqs	810	10	cell	cell	NN
cord-296347-fanlvxqs	810	11	survival	survival	NN
cord-296347-fanlvxqs	810	12	,	,	,
cord-296347-fanlvxqs	810	13	differentiation	differentiation	NN
cord-296347-fanlvxqs	810	14	,	,	,
cord-296347-fanlvxqs	810	15	and	and	CC
cord-296347-fanlvxqs	810	16	proliferation	proliferation	NN
cord-296347-fanlvxqs	810	17	.	.	.
cord-296347-fanlvxqs	811	1	Not	not	RB
cord-296347-fanlvxqs	811	2	surprisingly	surprisingly	RB
cord-296347-fanlvxqs	811	3	,	,	,
cord-296347-fanlvxqs	811	4	pathogens	pathogen	NNS
cord-296347-fanlvxqs	811	5	have	have	VBP
cord-296347-fanlvxqs	811	6	devoted	devote	VBN
cord-296347-fanlvxqs	811	7	much	much	JJ
cord-296347-fanlvxqs	811	8	energy	energy	NN
cord-296347-fanlvxqs	811	9	and	and	CC
cord-296347-fanlvxqs	811	10	coding	code	VBG
cord-296347-fanlvxqs	811	11	capacity	capacity	NN
cord-296347-fanlvxqs	811	12	to	to	TO
cord-296347-fanlvxqs	811	13	interfere	interfere	VB
cord-296347-fanlvxqs	811	14	with	with	IN
cord-296347-fanlvxqs	811	15	cell	cell	NN
cord-296347-fanlvxqs	811	16	signaling	signal	VBG
cord-296347-fanlvxqs	811	17	events	event	NNS
cord-296347-fanlvxqs	811	18	through	through	IN
cord-296347-fanlvxqs	811	19	interference	interference	NN
cord-296347-fanlvxqs	811	20	with	with	IN
cord-296347-fanlvxqs	811	21	the	the	DT
cord-296347-fanlvxqs	811	22	Ub	Ub	NNP
cord-296347-fanlvxqs	811	23	-	-	HYPH
cord-296347-fanlvxqs	811	24	proteasome	proteasome	NN
cord-296347-fanlvxqs	811	25	system	system	NN
cord-296347-fanlvxqs	811	26	.	.	.
cord-296347-fanlvxqs	812	1	An	an	DT
cord-296347-fanlvxqs	812	2	illustrative	illustrative	JJ
cord-296347-fanlvxqs	812	3	example	example	NN
cord-296347-fanlvxqs	812	4	is	be	VBZ
cord-296347-fanlvxqs	812	5	that	that	DT
cord-296347-fanlvxqs	812	6	of	of	IN
cord-296347-fanlvxqs	812	7	tumor	tumor	NN
cord-296347-fanlvxqs	812	8	viruses	virus	NNS
cord-296347-fanlvxqs	812	9	and	and	CC
cord-296347-fanlvxqs	812	10	degradation	degradation	NN
cord-296347-fanlvxqs	812	11	of	of	IN
cord-296347-fanlvxqs	812	12	cellular	cellular	JJ
cord-296347-fanlvxqs	812	13	tumor	tumor	NN
cord-296347-fanlvxqs	812	14	suppressor	suppressor	NN
cord-296347-fanlvxqs	812	15	proteins	protein	NNS
cord-296347-fanlvxqs	812	16	,	,	,
cord-296347-fanlvxqs	812	17	like	like	IN
cord-296347-fanlvxqs	812	18	the	the	DT
cord-296347-fanlvxqs	812	19	retinoblastoma	retinoblastoma	NN
cord-296347-fanlvxqs	812	20	protein	protein	NN
cord-296347-fanlvxqs	812	21	or	or	CC
cord-296347-fanlvxqs	812	22	p53	p53	NN
cord-296347-fanlvxqs	812	23	,	,	,
cord-296347-fanlvxqs	812	24	often	often	RB
cord-296347-fanlvxqs	812	25	resulting	result	VBG
cord-296347-fanlvxqs	812	26	in	in	IN
cord-296347-fanlvxqs	812	27	malignant	malignant	JJ
cord-296347-fanlvxqs	812	28	transformation	transformation	NN
cord-296347-fanlvxqs	812	29	(	(	-LRB-
cord-296347-fanlvxqs	812	30	Shackelford	Shackelford	NNP
cord-296347-fanlvxqs	812	31	and	and	CC
cord-296347-fanlvxqs	812	32	Pagano	Pagano	NNP
cord-296347-fanlvxqs	812	33	,	,	,
cord-296347-fanlvxqs	812	34	2005	2005	CD
cord-296347-fanlvxqs	812	35	)	)	-RRB-
cord-296347-fanlvxqs	812	36	.	.	.
cord-296347-fanlvxqs	813	1	There	there	EX
cord-296347-fanlvxqs	813	2	have	have	VBP
cord-296347-fanlvxqs	813	3	been	be	VBN
cord-296347-fanlvxqs	813	4	a	a	DT
cord-296347-fanlvxqs	813	5	number	number	NN
cord-296347-fanlvxqs	813	6	of	of	IN
cord-296347-fanlvxqs	813	7	recent	recent	JJ
cord-296347-fanlvxqs	813	8	reviews	review	NNS
cord-296347-fanlvxqs	813	9	on	on	IN
cord-296347-fanlvxqs	813	10	viral	viral	JJ
cord-296347-fanlvxqs	813	11	interference	interference	NN
cord-296347-fanlvxqs	813	12	with	with	IN
cord-296347-fanlvxqs	813	13	signaling	signal	VBG
cord-296347-fanlvxqs	813	14	pathways	pathway	NNS
cord-296347-fanlvxqs	813	15	,	,	,
cord-296347-fanlvxqs	813	16	so	so	IN
cord-296347-fanlvxqs	813	17	we	-PRON-	PRP
cord-296347-fanlvxqs	813	18	will	will	MD
cord-296347-fanlvxqs	813	19	not	not	RB
cord-296347-fanlvxqs	813	20	describe	describe	VB
cord-296347-fanlvxqs	813	21	this	this	DT
cord-296347-fanlvxqs	813	22	aspect	aspect	NN
cord-296347-fanlvxqs	813	23	in	in	IN
cord-296347-fanlvxqs	813	24	detail	detail	NN
cord-296347-fanlvxqs	813	25	here	here	RB
cord-296347-fanlvxqs	813	26	.	.	.
cord-296347-fanlvxqs	814	1	For	for	IN
cord-296347-fanlvxqs	814	2	comprehensive	comprehensive	JJ
cord-296347-fanlvxqs	814	3	reviews	review	NNS
cord-296347-fanlvxqs	814	4	,	,	,
cord-296347-fanlvxqs	814	5	the	the	DT
cord-296347-fanlvxqs	814	6	reader	reader	NN
cord-296347-fanlvxqs	814	7	is	be	VBZ
cord-296347-fanlvxqs	814	8	referred	refer	VBN
cord-296347-fanlvxqs	814	9	to	to	IN
cord-296347-fanlvxqs	814	10	Banks	Banks	NNP
cord-296347-fanlvxqs	814	11	et	et	NNP
cord-296347-fanlvxqs	814	12	al	al	NNP
cord-296347-fanlvxqs	814	13	.	.	.
cord-296347-fanlvxqs	815	1	(	(	-LRB-
cord-296347-fanlvxqs	815	2	2003	2003	CD
cord-296347-fanlvxqs	815	3	)	)	-RRB-
cord-296347-fanlvxqs	815	4	and	and	CC
cord-296347-fanlvxqs	815	5	Pagano	Pagano	NNP
cord-296347-fanlvxqs	815	6	(	(	-LRB-
cord-296347-fanlvxqs	815	7	2004	2004	CD
cord-296347-fanlvxqs	815	8	,	,	,
cord-296347-fanlvxqs	815	9	2005	2005	CD
cord-296347-fanlvxqs	815	10	)	)	-RRB-
cord-296347-fanlvxqs	815	11	.	.	.
cord-296347-fanlvxqs	816	1	In	in	IN
cord-296347-fanlvxqs	816	2	this	this	DT
cord-296347-fanlvxqs	816	3	chapter	chapter	NN
cord-296347-fanlvxqs	816	4	,	,	,
cord-296347-fanlvxqs	816	5	we	-PRON-	PRP
cord-296347-fanlvxqs	816	6	will	will	MD
cord-296347-fanlvxqs	816	7	focus	focus	VB
cord-296347-fanlvxqs	816	8	on	on	IN
cord-296347-fanlvxqs	816	9	a	a	DT
cord-296347-fanlvxqs	816	10	few	few	JJ
cord-296347-fanlvxqs	816	11	examples	example	NNS
cord-296347-fanlvxqs	816	12	of	of	IN
cord-296347-fanlvxqs	816	13	viral	viral	JJ
cord-296347-fanlvxqs	816	14	and	and	CC
cord-296347-fanlvxqs	816	15	bacterial	bacterial	JJ
cord-296347-fanlvxqs	816	16	interference	interference	NN
cord-296347-fanlvxqs	816	17	with	with	IN
cord-296347-fanlvxqs	816	18	the	the	DT
cord-296347-fanlvxqs	816	19	Ub	Ub	NNP
cord-296347-fanlvxqs	816	20	-	-	HYPH
cord-296347-fanlvxqs	816	21	proteasome	proteasome	NN
cord-296347-fanlvxqs	816	22	system	system	NN
cord-296347-fanlvxqs	816	23	that	that	WDT
cord-296347-fanlvxqs	816	24	illustrate	illustrate	VBP
cord-296347-fanlvxqs	816	25	how	how	WRB
cord-296347-fanlvxqs	816	26	the	the	DT
cord-296347-fanlvxqs	816	27	latter	latter	JJ
cord-296347-fanlvxqs	816	28	is	be	VBZ
cord-296347-fanlvxqs	816	29	crucial	crucial	JJ
cord-296347-fanlvxqs	816	30	for	for	IN
cord-296347-fanlvxqs	816	31	aspects	aspect	NNS
cord-296347-fanlvxqs	816	32	of	of	IN
cord-296347-fanlvxqs	816	33	pathogen	pathogen	NN
cord-296347-fanlvxqs	816	34	life	life	NN
cord-296347-fanlvxqs	816	35	cycles	cycle	NNS
cord-296347-fanlvxqs	816	36	that	that	WDT
cord-296347-fanlvxqs	816	37	are	be	VBP
cord-296347-fanlvxqs	816	38	as	as	RB
cord-296347-fanlvxqs	816	39	distinct	distinct	JJ
cord-296347-fanlvxqs	816	40	as	as	IN
cord-296347-fanlvxqs	816	41	integration	integration	NN
cord-296347-fanlvxqs	816	42	into	into	IN
cord-296347-fanlvxqs	816	43	host	host	NN
cord-296347-fanlvxqs	816	44	chromosomes	chromosome	NNS
cord-296347-fanlvxqs	816	45	,	,	,
cord-296347-fanlvxqs	816	46	exit	exit	NN
cord-296347-fanlvxqs	816	47	from	from	IN
cord-296347-fanlvxqs	816	48	the	the	DT
cord-296347-fanlvxqs	816	49	host	host	NN
cord-296347-fanlvxqs	816	50	cell	cell	NN
cord-296347-fanlvxqs	816	51	,	,	,
cord-296347-fanlvxqs	816	52	or	or	CC
cord-296347-fanlvxqs	816	53	RNA	RNA	NNP
cord-296347-fanlvxqs	816	54	interference	interference	NN
cord-296347-fanlvxqs	816	55	,	,	,
cord-296347-fanlvxqs	816	56	not	not	RB
cord-296347-fanlvxqs	816	57	to	to	TO
cord-296347-fanlvxqs	816	58	mention	mention	VB
cord-296347-fanlvxqs	816	59	control	control	NN
cord-296347-fanlvxqs	816	60	of	of	IN
cord-296347-fanlvxqs	816	61	the	the	DT
cord-296347-fanlvxqs	816	62	immune	immune	JJ
cord-296347-fanlvxqs	816	63	response	response	NN
cord-296347-fanlvxqs	816	64	.	.	.
cord-296347-fanlvxqs	817	1	As	as	IN
cord-296347-fanlvxqs	817	2	mentioned	mention	VBN
cord-296347-fanlvxqs	817	3	in	in	IN
cord-296347-fanlvxqs	817	4	the	the	DT
cord-296347-fanlvxqs	817	5	first	first	JJ
cord-296347-fanlvxqs	817	6	section	section	NN
cord-296347-fanlvxqs	817	7	of	of	IN
cord-296347-fanlvxqs	817	8	this	this	DT
cord-296347-fanlvxqs	817	9	chapter	chapter	NN
cord-296347-fanlvxqs	817	10	,	,	,
cord-296347-fanlvxqs	817	11	proteasome	proteasome	NN
cord-296347-fanlvxqs	817	12	-	-	HYPH
cord-296347-fanlvxqs	817	13	mediated	mediate	VBN
cord-296347-fanlvxqs	817	14	degradation	degradation	NN
cord-296347-fanlvxqs	817	15	of	of	IN
cord-296347-fanlvxqs	817	16	cytoplasmic	cytoplasmic	JJ
cord-296347-fanlvxqs	817	17	proteins	protein	NNS
cord-296347-fanlvxqs	817	18	as	as	RB
cord-296347-fanlvxqs	817	19	well	well	RB
cord-296347-fanlvxqs	817	20	as	as	IN
cord-296347-fanlvxqs	817	21	the	the	DT
cord-296347-fanlvxqs	817	22	proteolytic	proteolytic	JJ
cord-296347-fanlvxqs	817	23	events	event	NNS
cord-296347-fanlvxqs	817	24	in	in	IN
cord-296347-fanlvxqs	817	25	the	the	DT
cord-296347-fanlvxqs	817	26	endolysosomal	endolysosomal	JJ
cord-296347-fanlvxqs	817	27	system	system	NN
cord-296347-fanlvxqs	817	28	are	be	VBP
cord-296347-fanlvxqs	817	29	important	important	JJ
cord-296347-fanlvxqs	817	30	for	for	IN
cord-296347-fanlvxqs	817	31	class	class	NN
cord-296347-fanlvxqs	817	32	I	i	NN
cord-296347-fanlvxqs	817	33	and	and	CC
cord-296347-fanlvxqs	817	34	class	class	NN
cord-296347-fanlvxqs	817	35	II	II	NNP
cord-296347-fanlvxqs	817	36	MHC	MHC	NNP
cord-296347-fanlvxqs	817	37	presentation	presentation	NN
cord-296347-fanlvxqs	817	38	and	and	CC
cord-296347-fanlvxqs	817	39	cross	cross	NN
cord-296347-fanlvxqs	817	40	-	-	NN
cord-296347-fanlvxqs	817	41	presentation	presentation	NN
cord-296347-fanlvxqs	817	42	.	.	.
cord-296347-fanlvxqs	818	1	Mounting	mount	VBG
cord-296347-fanlvxqs	818	2	of	of	IN
cord-296347-fanlvxqs	818	3	an	an	DT
cord-296347-fanlvxqs	818	4	immune	immune	JJ
cord-296347-fanlvxqs	818	5	response	response	NN
cord-296347-fanlvxqs	818	6	involves	involve	VBZ
cord-296347-fanlvxqs	818	7	complicated	complicate	VBN
cord-296347-fanlvxqs	818	8	signaling	signal	VBG
cord-296347-fanlvxqs	818	9	cascades	cascade	NNS
cord-296347-fanlvxqs	818	10	like	like	IN
cord-296347-fanlvxqs	818	11	NF	NF	NNP
cord-296347-fanlvxqs	818	12	-	-	HYPH
cord-296347-fanlvxqs	818	13	kB	kB	NNP
cord-296347-fanlvxqs	818	14	and	and	CC
cord-296347-fanlvxqs	818	15	JAK	JAK	NNP
cord-296347-fanlvxqs	818	16	/	/	SYM
cord-296347-fanlvxqs	818	17	STAT	stat	NN
cord-296347-fanlvxqs	818	18	signaling	signaling	NN
cord-296347-fanlvxqs	818	19	,	,	,
cord-296347-fanlvxqs	818	20	which	which	WDT
cord-296347-fanlvxqs	818	21	are	be	VBP
cord-296347-fanlvxqs	818	22	heavily	heavily	RB
cord-296347-fanlvxqs	818	23	dependent	dependent	JJ
cord-296347-fanlvxqs	818	24	on	on	IN
cord-296347-fanlvxqs	818	25	the	the	DT
cord-296347-fanlvxqs	818	26	Ub	Ub	NNP
cord-296347-fanlvxqs	818	27	-	-	HYPH
cord-296347-fanlvxqs	818	28	proteasome	proteasome	NN
cord-296347-fanlvxqs	818	29	system	system	NN
cord-296347-fanlvxqs	818	30	,	,	,
cord-296347-fanlvxqs	818	31	and	and	CC
cord-296347-fanlvxqs	818	32	that	that	DT
cord-296347-fanlvxqs	818	33	can	can	MD
cord-296347-fanlvxqs	818	34	be	be	VB
cord-296347-fanlvxqs	818	35	manipulated	manipulate	VBN
cord-296347-fanlvxqs	818	36	from	from	IN
cord-296347-fanlvxqs	818	37	early	early	JJ
cord-296347-fanlvxqs	818	38	events	event	NNS
cord-296347-fanlvxqs	818	39	of	of	IN
cord-296347-fanlvxqs	818	40	cell	cell	NN
cord-296347-fanlvxqs	818	41	-	-	HYPH
cord-296347-fanlvxqs	818	42	surface	surface	NN
cord-296347-fanlvxqs	818	43	receptor	receptor	NN
cord-296347-fanlvxqs	818	44	-	-	HYPH
cord-296347-fanlvxqs	818	45	mediated	mediate	VBN
cord-296347-fanlvxqs	818	46	signaling	signaling	NN
cord-296347-fanlvxqs	818	47	,	,	,
cord-296347-fanlvxqs	818	48	for	for	IN
cord-296347-fanlvxqs	818	49	example	example	NN
cord-296347-fanlvxqs	818	50	,	,	,
cord-296347-fanlvxqs	818	51	to	to	IN
cord-296347-fanlvxqs	818	52	later	later	JJ
cord-296347-fanlvxqs	818	53	events	event	NNS
cord-296347-fanlvxqs	818	54	of	of	IN
cord-296347-fanlvxqs	818	55	ubiquitination	ubiquitination	NN
cord-296347-fanlvxqs	818	56	and	and	CC
cord-296347-fanlvxqs	818	57	deubiquitination	deubiquitination	NN
cord-296347-fanlvxqs	818	58	of	of	IN
cord-296347-fanlvxqs	818	59	downstream	downstream	JJ
cord-296347-fanlvxqs	818	60	targets	target	NNS
cord-296347-fanlvxqs	818	61	.	.	.
cord-296347-fanlvxqs	819	1	Certainly	certainly	RB
cord-296347-fanlvxqs	819	2	,	,	,
cord-296347-fanlvxqs	819	3	because	because	IN
cord-296347-fanlvxqs	819	4	of	of	IN
cord-296347-fanlvxqs	819	5	the	the	DT
cord-296347-fanlvxqs	819	6	central	central	JJ
cord-296347-fanlvxqs	819	7	role	role	NN
cord-296347-fanlvxqs	819	8	of	of	IN
cord-296347-fanlvxqs	819	9	the	the	DT
cord-296347-fanlvxqs	819	10	Ub	Ub	NNP
cord-296347-fanlvxqs	819	11	-	-	HYPH
cord-296347-fanlvxqs	819	12	proteasome	proteasome	VBN
cord-296347-fanlvxqs	819	13	system	system	NN
cord-296347-fanlvxqs	819	14	in	in	IN
cord-296347-fanlvxqs	819	15	many	many	JJ
cord-296347-fanlvxqs	819	16	different	different	JJ
cord-296347-fanlvxqs	819	17	aspects	aspect	NNS
cord-296347-fanlvxqs	819	18	of	of	IN
cord-296347-fanlvxqs	819	19	cellular	cellular	JJ
cord-296347-fanlvxqs	819	20	physiology	physiology	NN
cord-296347-fanlvxqs	819	21	,	,	,
cord-296347-fanlvxqs	819	22	interference	interference	NN
cord-296347-fanlvxqs	819	23	with	with	IN
cord-296347-fanlvxqs	819	24	this	this	DT
cord-296347-fanlvxqs	819	25	pathway	pathway	NN
cord-296347-fanlvxqs	819	26	will	will	MD
cord-296347-fanlvxqs	819	27	have	have	VB
cord-296347-fanlvxqs	819	28	pleiotropic	pleiotropic	JJ
cord-296347-fanlvxqs	819	29	effects	effect	NNS
cord-296347-fanlvxqs	819	30	,	,	,
cord-296347-fanlvxqs	819	31	and	and	CC
cord-296347-fanlvxqs	819	32	which	which	WDT
cord-296347-fanlvxqs	819	33	of	of	IN
cord-296347-fanlvxqs	819	34	the	the	DT
cord-296347-fanlvxqs	819	35	observed	observed	JJ
cord-296347-fanlvxqs	819	36	effects	effect	NNS
cord-296347-fanlvxqs	819	37	predominates	predominate	VBZ
cord-296347-fanlvxqs	819	38	may	may	MD
cord-296347-fanlvxqs	819	39	be	be	VB
cord-296347-fanlvxqs	819	40	difficult	difficult	JJ
cord-296347-fanlvxqs	819	41	to	to	TO
cord-296347-fanlvxqs	819	42	discern	discern	VB
cord-296347-fanlvxqs	819	43	.	.	.
cord-296347-fanlvxqs	820	1	It	-PRON-	PRP
cord-296347-fanlvxqs	820	2	is	be	VBZ
cord-296347-fanlvxqs	820	3	not	not	RB
cord-296347-fanlvxqs	820	4	our	-PRON-	PRP$
cord-296347-fanlvxqs	820	5	intention	intention	NN
cord-296347-fanlvxqs	820	6	to	to	TO
cord-296347-fanlvxqs	820	7	make	make	VB
cord-296347-fanlvxqs	820	8	the	the	DT
cord-296347-fanlvxqs	820	9	following	follow	VBG
cord-296347-fanlvxqs	820	10	a	a	DT
cord-296347-fanlvxqs	820	11	comprehensive	comprehensive	JJ
cord-296347-fanlvxqs	820	12	list	list	NN
cord-296347-fanlvxqs	820	13	.	.	.
cord-296347-fanlvxqs	821	1	We	-PRON-	PRP
cord-296347-fanlvxqs	821	2	rather	rather	RB
cord-296347-fanlvxqs	821	3	propose	propose	VBP
cord-296347-fanlvxqs	821	4	to	to	TO
cord-296347-fanlvxqs	821	5	provide	provide	VB
cord-296347-fanlvxqs	821	6	an	an	DT
cord-296347-fanlvxqs	821	7	overview	overview	NN
cord-296347-fanlvxqs	821	8	of	of	IN
cord-296347-fanlvxqs	821	9	the	the	DT
cord-296347-fanlvxqs	821	10	possibilities	possibility	NNS
cord-296347-fanlvxqs	821	11	of	of	IN
cord-296347-fanlvxqs	821	12	manipulation	manipulation	NN
cord-296347-fanlvxqs	821	13	of	of	IN
cord-296347-fanlvxqs	821	14	this	this	DT
cord-296347-fanlvxqs	821	15	system	system	NN
cord-296347-fanlvxqs	821	16	that	that	WDT
cord-296347-fanlvxqs	821	17	have	have	VBP
cord-296347-fanlvxqs	821	18	been	be	VBN
cord-296347-fanlvxqs	821	19	described	describe	VBN
cord-296347-fanlvxqs	821	20	for	for	IN
cord-296347-fanlvxqs	821	21	pathogens	pathogen	NNS
cord-296347-fanlvxqs	821	22	(	(	-LRB-
cord-296347-fanlvxqs	821	23	Fig	Fig	NNP
cord-296347-fanlvxqs	821	24	.	.	.
cord-296347-fanlvxqs	821	25	9	9	CD
cord-296347-fanlvxqs	821	26	)	)	-RRB-
cord-296347-fanlvxqs	821	27	.	.	.
cord-296347-fanlvxqs	822	1	We	-PRON-	PRP
cord-296347-fanlvxqs	822	2	discuss	discuss	VBP
cord-296347-fanlvxqs	822	3	in	in	IN
cord-296347-fanlvxqs	822	4	more	more	JJR
cord-296347-fanlvxqs	822	5	detail	detail	NN
cord-296347-fanlvxqs	822	6	pathogen	pathogen	NN
cord-296347-fanlvxqs	822	7	-	-	HYPH
cord-296347-fanlvxqs	822	8	encoded	encode	VBN
cord-296347-fanlvxqs	822	9	modulators	modulator	NNS
cord-296347-fanlvxqs	822	10	of	of	IN
cord-296347-fanlvxqs	822	11	the	the	DT
cord-296347-fanlvxqs	822	12	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	822	13	-	-	HYPH
cord-296347-fanlvxqs	822	14	proteasome	proteasome	VBN
cord-296347-fanlvxqs	822	15	system	system	NN
cord-296347-fanlvxqs	822	16	,	,	,
cord-296347-fanlvxqs	822	17	ranging	range	VBG
cord-296347-fanlvxqs	822	18	from	from	IN
cord-296347-fanlvxqs	822	19	pathogen	pathogen	NN
cord-296347-fanlvxqs	822	20	-	-	HYPH
cord-296347-fanlvxqs	822	21	encoded	encode	VBN
cord-296347-fanlvxqs	822	22	proteolysis	proteolysis	NN
cord-296347-fanlvxqs	822	23	-	-	HYPH
cord-296347-fanlvxqs	822	24	resistant	resistant	JJ
cord-296347-fanlvxqs	822	25	peptides	peptide	NNS
cord-296347-fanlvxqs	822	26	,	,	,
cord-296347-fanlvxqs	822	27	to	to	IN
cord-296347-fanlvxqs	822	28	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	822	29	ligases	ligase	NNS
cord-296347-fanlvxqs	822	30	and	and	CC
cord-296347-fanlvxqs	822	31	DUB	DUB	NNP
cord-296347-fanlvxqs	822	32	,	,	,
cord-296347-fanlvxqs	822	33	with	with	IN
cord-296347-fanlvxqs	822	34	obvious	obvious	JJ
cord-296347-fanlvxqs	822	35	implications	implication	NNS
cord-296347-fanlvxqs	822	36	for	for	IN
cord-296347-fanlvxqs	822	37	the	the	DT
cord-296347-fanlvxqs	822	38	viral	viral	JJ
cord-296347-fanlvxqs	822	39	or	or	CC
cord-296347-fanlvxqs	822	40	bacterial	bacterial	JJ
cord-296347-fanlvxqs	822	41	life	life	NN
cord-296347-fanlvxqs	822	42	cycle	cycle	NN
cord-296347-fanlvxqs	822	43	or	or	CC
cord-296347-fanlvxqs	822	44	with	with	IN
cord-296347-fanlvxqs	822	45	consequences	consequence	NNS
cord-296347-fanlvxqs	822	46	for	for	IN
cord-296347-fanlvxqs	822	47	the	the	DT
cord-296347-fanlvxqs	822	48	control	control	NN
cord-296347-fanlvxqs	822	49	of	of	IN
cord-296347-fanlvxqs	822	50	host	host	NN
cord-296347-fanlvxqs	822	51	immune	immune	JJ
cord-296347-fanlvxqs	822	52	responses	response	NNS
cord-296347-fanlvxqs	822	53	.	.	.
cord-296347-fanlvxqs	823	1	We	-PRON-	PRP
cord-296347-fanlvxqs	823	2	elaborate	elaborate	VBP
cord-296347-fanlvxqs	823	3	on	on	IN
cord-296347-fanlvxqs	823	4	novel	novel	JJ
cord-296347-fanlvxqs	823	5	pathogen	pathogen	NN
cord-296347-fanlvxqs	823	6	-	-	HYPH
cord-296347-fanlvxqs	823	7	encoded	encode	VBN
cord-296347-fanlvxqs	823	8	DUBs	dub	NNS
cord-296347-fanlvxqs	823	9	and	and	CC
cord-296347-fanlvxqs	823	10	their	-PRON-	PRP$
cord-296347-fanlvxqs	823	11	putative	putative	JJ
cord-296347-fanlvxqs	823	12	functions	function	NNS
cord-296347-fanlvxqs	823	13	.	.	.
cord-296347-fanlvxqs	824	1	The	the	DT
cord-296347-fanlvxqs	824	2	classic	classic	JJ
cord-296347-fanlvxqs	824	3	example	example	NN
cord-296347-fanlvxqs	824	4	of	of	IN
cord-296347-fanlvxqs	824	5	a	a	DT
cord-296347-fanlvxqs	824	6	viral	viral	JJ
cord-296347-fanlvxqs	824	7	protein	protein	NN
cord-296347-fanlvxqs	824	8	that	that	WDT
cord-296347-fanlvxqs	824	9	interferes	interfere	VBZ
cord-296347-fanlvxqs	824	10	with	with	IN
cord-296347-fanlvxqs	824	11	proteasomal	proteasomal	JJ
cord-296347-fanlvxqs	824	12	processing	processing	NN
cord-296347-fanlvxqs	824	13	is	be	VBZ
cord-296347-fanlvxqs	824	14	the	the	DT
cord-296347-fanlvxqs	824	15	EBNA-1	EBNA-1	NNP
cord-296347-fanlvxqs	824	16	.	.	.
cord-296347-fanlvxqs	825	1	The	the	DT
cord-296347-fanlvxqs	825	2	EBNA-1	EBNA-1	NNP
cord-296347-fanlvxqs	825	3	protein	protein	NN
cord-296347-fanlvxqs	825	4	contains	contain	VBZ
cord-296347-fanlvxqs	825	5	an	an	DT
cord-296347-fanlvxqs	825	6	internal	internal	JJ
cord-296347-fanlvxqs	825	7	repeat	repeat	NN
cord-296347-fanlvxqs	825	8	exclusively	exclusively	RB
cord-296347-fanlvxqs	825	9	composed	compose	VBN
cord-296347-fanlvxqs	825	10	of	of	IN
cord-296347-fanlvxqs	825	11	glycines	glycine	NNS
cord-296347-fanlvxqs	825	12	and	and	CC
cord-296347-fanlvxqs	825	13	alanines	alanine	NNS
cord-296347-fanlvxqs	825	14	,	,	,
cord-296347-fanlvxqs	825	15	the	the	DT
cord-296347-fanlvxqs	825	16	Gly	Gly	NNP
cord-296347-fanlvxqs	825	17	-	-	HYPH
cord-296347-fanlvxqs	825	18	Ala	Ala	NNP
cord-296347-fanlvxqs	825	19	repeat	repeat	NN
cord-296347-fanlvxqs	825	20	,	,	,
cord-296347-fanlvxqs	825	21	which	which	WDT
cord-296347-fanlvxqs	825	22	not	not	RB
cord-296347-fanlvxqs	825	23	only	only	RB
cord-296347-fanlvxqs	825	24	interferes	interfere	VBZ
cord-296347-fanlvxqs	825	25	with	with	IN
cord-296347-fanlvxqs	825	26	its	-PRON-	PRP$
cord-296347-fanlvxqs	825	27	own	own	JJ
cord-296347-fanlvxqs	825	28	proteasomal	proteasomal	JJ
cord-296347-fanlvxqs	825	29	proteolysis	proteolysis	NN
cord-296347-fanlvxqs	825	30	(	(	-LRB-
cord-296347-fanlvxqs	825	31	Levitskaya	Levitskaya	NNP
cord-296347-fanlvxqs	825	32	et	et	NNP
cord-296347-fanlvxqs	825	33	al	al	NNP
cord-296347-fanlvxqs	825	34	.	.	NNP
cord-296347-fanlvxqs	825	35	,	,	,
cord-296347-fanlvxqs	825	36	1995	1995	CD
cord-296347-fanlvxqs	825	37	)	)	-RRB-
cord-296347-fanlvxqs	825	38	,	,	,
cord-296347-fanlvxqs	825	39	but	but	CC
cord-296347-fanlvxqs	825	40	also	also	RB
cord-296347-fanlvxqs	825	41	reduces	reduce	VBZ
cord-296347-fanlvxqs	825	42	its	-PRON-	PRP$
cord-296347-fanlvxqs	825	43	rate	rate	NN
cord-296347-fanlvxqs	825	44	of	of	IN
cord-296347-fanlvxqs	825	45	translation	translation	NN
cord-296347-fanlvxqs	825	46	,	,	,
cord-296347-fanlvxqs	825	47	blocking	block	VBG
cord-296347-fanlvxqs	825	48	viral	viral	JJ
cord-296347-fanlvxqs	825	49	DRIPs	drip	NNS
cord-296347-fanlvxqs	825	50	formation	formation	NN
cord-296347-fanlvxqs	825	51	and	and	CC
cord-296347-fanlvxqs	825	52	inhibiting	inhibit	VBG
cord-296347-fanlvxqs	825	53	the	the	DT
cord-296347-fanlvxqs	825	54	presentation	presentation	NN
cord-296347-fanlvxqs	825	55	Figure	figure	NN
cord-296347-fanlvxqs	825	56	9	9	CD
cord-296347-fanlvxqs	825	57	Pathogen	Pathogen	NNP
cord-296347-fanlvxqs	825	58	interference	interference	NN
cord-296347-fanlvxqs	825	59	with	with	IN
cord-296347-fanlvxqs	825	60	the	the	DT
cord-296347-fanlvxqs	825	61	Ub	Ub	NNP
cord-296347-fanlvxqs	825	62	-	-	HYPH
cord-296347-fanlvxqs	825	63	proteasome	proteasome	NN
cord-296347-fanlvxqs	825	64	system	system	NN
cord-296347-fanlvxqs	825	65	.	.	.
cord-296347-fanlvxqs	826	1	Pathogens	pathogen	NNS
cord-296347-fanlvxqs	826	2	interfere	interfere	VBP
cord-296347-fanlvxqs	826	3	with	with	IN
cord-296347-fanlvxqs	826	4	the	the	DT
cord-296347-fanlvxqs	826	5	Ub	Ub	NNP
cord-296347-fanlvxqs	826	6	-	-	HYPH
cord-296347-fanlvxqs	826	7	proteasome	proteasome	NN
cord-296347-fanlvxqs	826	8	system	system	NN
cord-296347-fanlvxqs	826	9	not	not	RB
cord-296347-fanlvxqs	826	10	only	only	RB
cord-296347-fanlvxqs	826	11	to	to	TO
cord-296347-fanlvxqs	826	12	manipulate	manipulate	VB
cord-296347-fanlvxqs	826	13	antigen	antigen	NN
cord-296347-fanlvxqs	826	14	presentation	presentation	NN
cord-296347-fanlvxqs	826	15	and	and	CC
cord-296347-fanlvxqs	826	16	other	other	JJ
cord-296347-fanlvxqs	826	17	aspects	aspect	NNS
cord-296347-fanlvxqs	826	18	of	of	IN
cord-296347-fanlvxqs	826	19	the	the	DT
cord-296347-fanlvxqs	826	20	immune	immune	JJ
cord-296347-fanlvxqs	826	21	system	system	NN
cord-296347-fanlvxqs	826	22	,	,	,
cord-296347-fanlvxqs	826	23	but	but	CC
cord-296347-fanlvxqs	826	24	for	for	IN
cord-296347-fanlvxqs	826	25	processes	process	NNS
cord-296347-fanlvxqs	826	26	as	as	RB
cord-296347-fanlvxqs	826	27	distinct	distinct	JJ
cord-296347-fanlvxqs	826	28	as	as	IN
cord-296347-fanlvxqs	826	29	chromosomal	chromosomal	JJ
cord-296347-fanlvxqs	826	30	integration	integration	NN
cord-296347-fanlvxqs	826	31	,	,	,
cord-296347-fanlvxqs	826	32	virus	virus	NN
cord-296347-fanlvxqs	826	33	budding	bud	VBG
cord-296347-fanlvxqs	826	34	,	,	,
cord-296347-fanlvxqs	826	35	RNA	RNA	NNP
cord-296347-fanlvxqs	826	36	interference	interference	NN
cord-296347-fanlvxqs	826	37	,	,	,
cord-296347-fanlvxqs	826	38	and	and	CC
cord-296347-fanlvxqs	826	39	many	many	JJ
cord-296347-fanlvxqs	826	40	others	other	NNS
cord-296347-fanlvxqs	826	41	.	.	.
cord-296347-fanlvxqs	827	1	They	-PRON-	PRP
cord-296347-fanlvxqs	827	2	may	may	MD
cord-296347-fanlvxqs	827	3	rely	rely	VB
cord-296347-fanlvxqs	827	4	on	on	IN
cord-296347-fanlvxqs	827	5	hijacking	hijacking	NN
cord-296347-fanlvxqs	827	6	of	of	IN
cord-296347-fanlvxqs	827	7	host	host	NN
cord-296347-fanlvxqs	827	8	E3	e3	NN
cord-296347-fanlvxqs	827	9	ligase	ligase	NN
cord-296347-fanlvxqs	827	10	activities	activity	NNS
cord-296347-fanlvxqs	827	11	or	or	CC
cord-296347-fanlvxqs	827	12	encode	encode	VB
cord-296347-fanlvxqs	827	13	their	-PRON-	PRP$
cord-296347-fanlvxqs	827	14	own	own	JJ
cord-296347-fanlvxqs	827	15	.	.	.
cord-296347-fanlvxqs	828	1	Pathogens	pathogen	NNS
cord-296347-fanlvxqs	828	2	can	can	MD
cord-296347-fanlvxqs	828	3	manipulate	manipulate	VB
cord-296347-fanlvxqs	828	4	host	host	NN
cord-296347-fanlvxqs	828	5	DUBs	dub	NNS
cord-296347-fanlvxqs	828	6	as	as	RB
cord-296347-fanlvxqs	828	7	well	well	RB
cord-296347-fanlvxqs	828	8	as	as	IN
cord-296347-fanlvxqs	828	9	encode	encode	VB
cord-296347-fanlvxqs	828	10	DUB	DUB	NNP
cord-296347-fanlvxqs	828	11	activities	activity	NNS
cord-296347-fanlvxqs	828	12	.	.	.
cord-296347-fanlvxqs	829	1	The	the	DT
cord-296347-fanlvxqs	829	2	function	function	NN
cord-296347-fanlvxqs	829	3	of	of	IN
cord-296347-fanlvxqs	829	4	pathogen	pathogen	NN
cord-296347-fanlvxqs	829	5	-	-	HYPH
cord-296347-fanlvxqs	829	6	encoded	encode	VBN
cord-296347-fanlvxqs	829	7	DUBs	dub	NNS
cord-296347-fanlvxqs	829	8	remains	remain	VBZ
cord-296347-fanlvxqs	829	9	a	a	DT
cord-296347-fanlvxqs	829	10	mistery	mistery	NN
cord-296347-fanlvxqs	829	11	.	.	.
cord-296347-fanlvxqs	830	1	of	of	IN
cord-296347-fanlvxqs	830	2	EBNA-1	EBNA-1	NNP
cord-296347-fanlvxqs	830	3	class	class	NN
cord-296347-fanlvxqs	830	4	I	-PRON-	PRP
cord-296347-fanlvxqs	830	5	MHC	MHC	NNP
cord-296347-fanlvxqs	830	6	-	-	HYPH
cord-296347-fanlvxqs	830	7	restricted	restrict	VBN
cord-296347-fanlvxqs	830	8	T	T	NNP
cord-296347-fanlvxqs	830	9	cell	cell	NN
cord-296347-fanlvxqs	830	10	epitopes	epitope	NNS
cord-296347-fanlvxqs	831	1	(	(	-LRB-
cord-296347-fanlvxqs	831	2	Yin	Yin	NNP
cord-296347-fanlvxqs	831	3	et	et	NNP
cord-296347-fanlvxqs	831	4	al	al	NNP
cord-296347-fanlvxqs	831	5	.	.	NNP
cord-296347-fanlvxqs	831	6	,	,	,
cord-296347-fanlvxqs	831	7	2003	2003	CD
cord-296347-fanlvxqs	831	8	)	)	-RRB-
cord-296347-fanlvxqs	831	9	.	.	.
cord-296347-fanlvxqs	832	1	A	a	DT
cord-296347-fanlvxqs	832	2	single	single	JJ
cord-296347-fanlvxqs	832	3	residue	residue	NN
cord-296347-fanlvxqs	832	4	change	change	NN
cord-296347-fanlvxqs	832	5	in	in	IN
cord-296347-fanlvxqs	832	6	the	the	DT
cord-296347-fanlvxqs	832	7	mouse	mouse	NN
cord-296347-fanlvxqs	832	8	leukemia	leukemia	NN
cord-296347-fanlvxqs	832	9	virus	virus	NN
cord-296347-fanlvxqs	832	10	(	(	-LRB-
cord-296347-fanlvxqs	832	11	MuLV)-derived	mulv)-derived	JJ
cord-296347-fanlvxqs	832	12	CTL	ctl	NN
cord-296347-fanlvxqs	832	13	epitope	epitope	NN
cord-296347-fanlvxqs	832	14	(	(	-LRB-
cord-296347-fanlvxqs	832	15	from	from	IN
cord-296347-fanlvxqs	832	16	KSPWFTTL	KSPWFTTL	NNP
cord-296347-fanlvxqs	832	17	to	to	IN
cord-296347-fanlvxqs	832	18	RSPWFTTL	RSPWFTTL	NNP
cord-296347-fanlvxqs	832	19	)	)	-RRB-
cord-296347-fanlvxqs	832	20	can	can	MD
cord-296347-fanlvxqs	832	21	eliminate	eliminate	VB
cord-296347-fanlvxqs	832	22	the	the	DT
cord-296347-fanlvxqs	832	23	proteolytic	proteolytic	JJ
cord-296347-fanlvxqs	832	24	cleavage	cleavage	NN
cord-296347-fanlvxqs	832	25	site	site	NN
cord-296347-fanlvxqs	832	26	required	require	VBN
cord-296347-fanlvxqs	832	27	for	for	IN
cord-296347-fanlvxqs	832	28	its	-PRON-	PRP$
cord-296347-fanlvxqs	832	29	presentation	presentation	NN
cord-296347-fanlvxqs	832	30	(	(	-LRB-
cord-296347-fanlvxqs	832	31	Ossendorp	Ossendorp	NNP
cord-296347-fanlvxqs	832	32	et	et	NNP
cord-296347-fanlvxqs	832	33	al	al	NNP
cord-296347-fanlvxqs	832	34	.	.	NNP
cord-296347-fanlvxqs	832	35	,	,	,
cord-296347-fanlvxqs	832	36	1996	1996	CD
cord-296347-fanlvxqs	832	37	)	)	-RRB-
cord-296347-fanlvxqs	832	38	.	.	.
cord-296347-fanlvxqs	833	1	As	as	IN
cord-296347-fanlvxqs	833	2	discussed	discuss	VBN
cord-296347-fanlvxqs	833	3	earlier	early	RBR
cord-296347-fanlvxqs	833	4	,	,	,
cord-296347-fanlvxqs	833	5	phosphorylation	phosphorylation	NN
cord-296347-fanlvxqs	833	6	of	of	IN
cord-296347-fanlvxqs	833	7	the	the	DT
cord-296347-fanlvxqs	833	8	HCMV	HCMV	NNP
cord-296347-fanlvxqs	833	9	IE-1	IE-1	NNP
cord-296347-fanlvxqs	833	10	by	by	IN
cord-296347-fanlvxqs	833	11	the	the	DT
cord-296347-fanlvxqs	833	12	HCMV	HCMV	NNP
cord-296347-fanlvxqs	833	13	pp65	pp65	NNP
cord-296347-fanlvxqs	833	14	tegument	tegument	NNP
cord-296347-fanlvxqs	833	15	protein	protein	NN
cord-296347-fanlvxqs	833	16	interferes	interfere	VBZ
cord-296347-fanlvxqs	833	17	with	with	IN
cord-296347-fanlvxqs	833	18	production	production	NN
cord-296347-fanlvxqs	833	19	of	of	IN
cord-296347-fanlvxqs	833	20	IE-1-derived	ie-1-derive	VBN
cord-296347-fanlvxqs	833	21	peptides	peptide	NNS
cord-296347-fanlvxqs	833	22	(	(	-LRB-
cord-296347-fanlvxqs	833	23	Gilbert	Gilbert	NNP
cord-296347-fanlvxqs	833	24	et	et	NNP
cord-296347-fanlvxqs	833	25	al	al	NNP
cord-296347-fanlvxqs	833	26	.	.	NNP
cord-296347-fanlvxqs	833	27	,	,	,
cord-296347-fanlvxqs	833	28	1996	1996	CD
cord-296347-fanlvxqs	833	29	)	)	-RRB-
cord-296347-fanlvxqs	833	30	.	.	.
cord-296347-fanlvxqs	834	1	The	the	DT
cord-296347-fanlvxqs	834	2	HIV-1	HIV-1	NNP
cord-296347-fanlvxqs	834	3	transcriptional	transcriptional	NN
cord-296347-fanlvxqs	834	4	activator	activator	NN
cord-296347-fanlvxqs	834	5	(	(	-LRB-
cord-296347-fanlvxqs	834	6	Tat	tat	NN
cord-296347-fanlvxqs	834	7	)	)	-RRB-
cord-296347-fanlvxqs	834	8	protein	protein	NN
cord-296347-fanlvxqs	834	9	manipulates	manipulate	VBZ
cord-296347-fanlvxqs	834	10	26S	26S	NNP
cord-296347-fanlvxqs	834	11	proteasome	proteasome	NN
cord-296347-fanlvxqs	834	12	function	function	NN
cord-296347-fanlvxqs	834	13	by	by	IN
cord-296347-fanlvxqs	834	14	directly	directly	RB
cord-296347-fanlvxqs	834	15	interacting	interact	VBG
cord-296347-fanlvxqs	834	16	with	with	IN
cord-296347-fanlvxqs	834	17	the	the	DT
cord-296347-fanlvxqs	834	18	LMP7	LMP7	NNP
cord-296347-fanlvxqs	834	19	and	and	CC
cord-296347-fanlvxqs	834	20	MECL1	MECL1	NNP
cord-296347-fanlvxqs	834	21	subunits	subunit	NNS
cord-296347-fanlvxqs	834	22	of	of	IN
cord-296347-fanlvxqs	834	23	the	the	DT
cord-296347-fanlvxqs	834	24	proteasome	proteasome	NN
cord-296347-fanlvxqs	834	25	and	and	CC
cord-296347-fanlvxqs	834	26	competing	compete	VBG
cord-296347-fanlvxqs	834	27	with	with	IN
cord-296347-fanlvxqs	834	28	the	the	DT
cord-296347-fanlvxqs	834	29	11S	11S	NNP
cord-296347-fanlvxqs	834	30	proteasome	proteasome	NN
cord-296347-fanlvxqs	834	31	for	for	IN
cord-296347-fanlvxqs	834	32	binding	bind	VBG
cord-296347-fanlvxqs	834	33	to	to	IN
cord-296347-fanlvxqs	834	34	the	the	DT
cord-296347-fanlvxqs	834	35	20S	20s	CD
cord-296347-fanlvxqs	834	36	proteasome	proteasome	VBN
cord-296347-fanlvxqs	834	37	(	(	-LRB-
cord-296347-fanlvxqs	834	38	Andre	Andre	NNP
cord-296347-fanlvxqs	834	39	et	et	NNP
cord-296347-fanlvxqs	834	40	al	al	NNP
cord-296347-fanlvxqs	834	41	.	.	NNP
cord-296347-fanlvxqs	834	42	,	,	,
cord-296347-fanlvxqs	834	43	1998	1998	CD
cord-296347-fanlvxqs	834	44	;	;	:
cord-296347-fanlvxqs	835	1	Apcher	Apcher	NNP
cord-296347-fanlvxqs	835	2	et	et	NNP
cord-296347-fanlvxqs	835	3	al	al	NNP
cord-296347-fanlvxqs	835	4	.	.	NNP
cord-296347-fanlvxqs	835	5	,	,	,
cord-296347-fanlvxqs	835	6	2003	2003	CD
cord-296347-fanlvxqs	835	7	)	)	-RRB-
cord-296347-fanlvxqs	835	8	,	,	,
cord-296347-fanlvxqs	835	9	leading	lead	VBG
cord-296347-fanlvxqs	835	10	to	to	IN
cord-296347-fanlvxqs	835	11	inhibition	inhibition	NN
cord-296347-fanlvxqs	835	12	of	of	IN
cord-296347-fanlvxqs	835	13	proteolytic	proteolytic	JJ
cord-296347-fanlvxqs	835	14	activity	activity	NN
cord-296347-fanlvxqs	835	15	.	.	.
cord-296347-fanlvxqs	836	1	Tat	Tat	NNP
cord-296347-fanlvxqs	836	2	also	also	RB
cord-296347-fanlvxqs	836	3	acts	act	VBZ
cord-296347-fanlvxqs	836	4	at	at	IN
cord-296347-fanlvxqs	836	5	the	the	DT
cord-296347-fanlvxqs	836	6	transcriptional	transcriptional	JJ
cord-296347-fanlvxqs	836	7	level	level	NN
cord-296347-fanlvxqs	836	8	by	by	IN
cord-296347-fanlvxqs	836	9	modifying	modify	VBG
cord-296347-fanlvxqs	836	10	proteasome	proteasome	VBN
cord-296347-fanlvxqs	836	11	composition	composition	NN
cord-296347-fanlvxqs	836	12	by	by	IN
cord-296347-fanlvxqs	836	13	upregulating	upregulate	VBG
cord-296347-fanlvxqs	836	14	the	the	DT
cord-296347-fanlvxqs	836	15	LMP7	LMP7	NNP
cord-296347-fanlvxqs	836	16	and	and	CC
cord-296347-fanlvxqs	836	17	MECL1	mecl1	NN
cord-296347-fanlvxqs	836	18	subunits	subunit	NNS
cord-296347-fanlvxqs	836	19	and	and	CC
cord-296347-fanlvxqs	836	20	downregulating	downregulate	VBG
cord-296347-fanlvxqs	836	21	the	the	DT
cord-296347-fanlvxqs	836	22	LMP2	lmp2	NN
cord-296347-fanlvxqs	836	23	subunit	subunit	NN
cord-296347-fanlvxqs	836	24	,	,	,
cord-296347-fanlvxqs	836	25	leading	lead	VBG
cord-296347-fanlvxqs	836	26	to	to	IN
cord-296347-fanlvxqs	836	27	an	an	DT
cord-296347-fanlvxqs	836	28	increased	increase	VBN
cord-296347-fanlvxqs	836	29	presentation	presentation	NN
cord-296347-fanlvxqs	836	30	of	of	IN
cord-296347-fanlvxqs	836	31	cryptic	cryptic	JJ
cord-296347-fanlvxqs	836	32	and	and	CC
cord-296347-fanlvxqs	836	33	subdominant	subdominant	JJ
cord-296347-fanlvxqs	836	34	CTL	CTL	NNP
cord-296347-fanlvxqs	836	35	epitopes	epitope	NNS
cord-296347-fanlvxqs	836	36	(	(	-LRB-
cord-296347-fanlvxqs	836	37	Gavioli	Gavioli	NNP
cord-296347-fanlvxqs	836	38	et	et	NNP
cord-296347-fanlvxqs	836	39	al	al	NNP
cord-296347-fanlvxqs	836	40	.	.	NNP
cord-296347-fanlvxqs	836	41	,	,	,
cord-296347-fanlvxqs	836	42	2004	2004	CD
cord-296347-fanlvxqs	836	43	)	)	-RRB-
cord-296347-fanlvxqs	836	44	.	.	.
cord-296347-fanlvxqs	837	1	By	by	IN
cord-296347-fanlvxqs	837	2	preventing	prevent	VBG
cord-296347-fanlvxqs	837	3	display	display	NN
cord-296347-fanlvxqs	837	4	of	of	IN
cord-296347-fanlvxqs	837	5	viral	viral	JJ
cord-296347-fanlvxqs	837	6	peptides	peptide	NNS
cord-296347-fanlvxqs	837	7	,	,	,
cord-296347-fanlvxqs	837	8	these	these	DT
cord-296347-fanlvxqs	837	9	viral	viral	JJ
cord-296347-fanlvxqs	837	10	proteins	protein	NNS
cord-296347-fanlvxqs	837	11	interfere	interfere	VBP
cord-296347-fanlvxqs	837	12	with	with	IN
cord-296347-fanlvxqs	837	13	cytotoxic	cytotoxic	JJ
cord-296347-fanlvxqs	837	14	T	T	NNP
cord-296347-fanlvxqs	837	15	cell	cell	NN
cord-296347-fanlvxqs	837	16	recognition	recognition	NN
cord-296347-fanlvxqs	837	17	.	.	.
cord-296347-fanlvxqs	838	1	Salmonella	Salmonella	NNP
cord-296347-fanlvxqs	838	2	enterica	enterica	NNP
cord-296347-fanlvxqs	839	1	serovar	serovar	NNP
cord-296347-fanlvxqs	839	2	typhimurium	typhimurium	NNP
cord-296347-fanlvxqs	839	3	is	be	VBZ
cord-296347-fanlvxqs	839	4	an	an	DT
cord-296347-fanlvxqs	839	5	important	important	JJ
cord-296347-fanlvxqs	839	6	bacterial	bacterial	JJ
cord-296347-fanlvxqs	839	7	pathogen	pathogen	NN
cord-296347-fanlvxqs	839	8	,	,	,
cord-296347-fanlvxqs	839	9	the	the	DT
cord-296347-fanlvxqs	839	10	causative	causative	JJ
cord-296347-fanlvxqs	839	11	agent	agent	NN
cord-296347-fanlvxqs	839	12	of	of	IN
cord-296347-fanlvxqs	839	13	food	food	NN
cord-296347-fanlvxqs	839	14	poisoning	poisoning	NN
cord-296347-fanlvxqs	839	15	and	and	CC
cord-296347-fanlvxqs	839	16	typhoid	typhoid	NN
cord-296347-fanlvxqs	839	17	fever	fever	NN
cord-296347-fanlvxqs	839	18	.	.	.
cord-296347-fanlvxqs	840	1	S.	S.	NNP
cord-296347-fanlvxqs	840	2	typhimurium	typhimurium	NNP
cord-296347-fanlvxqs	840	3	temporally	temporally	RB
cord-296347-fanlvxqs	840	4	regulates	regulate	VBZ
cord-296347-fanlvxqs	840	5	the	the	DT
cord-296347-fanlvxqs	840	6	initial	initial	JJ
cord-296347-fanlvxqs	840	7	phase	phase	NN
cord-296347-fanlvxqs	840	8	of	of	IN
cord-296347-fanlvxqs	840	9	bacterial	bacterial	JJ
cord-296347-fanlvxqs	840	10	internalization	internalization	NN
cord-296347-fanlvxqs	840	11	and	and	CC
cord-296347-fanlvxqs	840	12	host	host	NN
cord-296347-fanlvxqs	840	13	cell	cell	NN
cord-296347-fanlvxqs	840	14	recovery	recovery	NN
cord-296347-fanlvxqs	840	15	after	after	IN
cord-296347-fanlvxqs	840	16	invasion	invasion	NN
cord-296347-fanlvxqs	840	17	through	through	IN
cord-296347-fanlvxqs	840	18	two	two	CD
cord-296347-fanlvxqs	840	19	type	type	NN
cord-296347-fanlvxqs	840	20	III	iii	CD
cord-296347-fanlvxqs	840	21	secretion	secretion	NN
cord-296347-fanlvxqs	840	22	system	system	NN
cord-296347-fanlvxqs	840	23	(	(	-LRB-
cord-296347-fanlvxqs	840	24	TTSS)-delivered	ttss)-delivered	JJ
cord-296347-fanlvxqs	840	25	substrates	substrate	NNS
cord-296347-fanlvxqs	840	26	,	,	,
cord-296347-fanlvxqs	840	27	SptP	SptP	NNP
cord-296347-fanlvxqs	840	28	and	and	CC
cord-296347-fanlvxqs	840	29	SopE	SopE	NNP
cord-296347-fanlvxqs	840	30	with	with	IN
cord-296347-fanlvxqs	840	31	different	different	JJ
cord-296347-fanlvxqs	840	32	proteasomal	proteasomal	JJ
cord-296347-fanlvxqs	840	33	half	half	NN
cord-296347-fanlvxqs	840	34	lives	life	NNS
cord-296347-fanlvxqs	840	35	(	(	-LRB-
cord-296347-fanlvxqs	840	36	Kubori	Kubori	NNP
cord-296347-fanlvxqs	840	37	and	and	CC
cord-296347-fanlvxqs	840	38	Galan	Galan	NNP
cord-296347-fanlvxqs	840	39	,	,	,
cord-296347-fanlvxqs	840	40	2003	2003	CD
cord-296347-fanlvxqs	840	41	)	)	-RRB-
cord-296347-fanlvxqs	840	42	.	.	.
cord-296347-fanlvxqs	841	1	SopE	SopE	NNP
cord-296347-fanlvxqs	841	2	is	be	VBZ
cord-296347-fanlvxqs	841	3	a	a	DT
cord-296347-fanlvxqs	841	4	bacterial	bacterial	JJ
cord-296347-fanlvxqs	841	5	guanine	guanine	NN
cord-296347-fanlvxqs	841	6	nucleotide	nucleotide	JJ
cord-296347-fanlvxqs	841	7	exchange	exchange	NN
cord-296347-fanlvxqs	841	8	factor	factor	NN
cord-296347-fanlvxqs	841	9	(	(	-LRB-
cord-296347-fanlvxqs	841	10	GEF	gef	NN
cord-296347-fanlvxqs	841	11	)	)	-RRB-
cord-296347-fanlvxqs	841	12	delivered	deliver	VBN
cord-296347-fanlvxqs	841	13	by	by	IN
cord-296347-fanlvxqs	841	14	a	a	DT
cord-296347-fanlvxqs	841	15	TTSS	TTSS	NNP
cord-296347-fanlvxqs	841	16	that	that	WDT
cord-296347-fanlvxqs	841	17	mimics	mimic	VBZ
cord-296347-fanlvxqs	841	18	a	a	DT
cord-296347-fanlvxqs	841	19	host	host	NN
cord-296347-fanlvxqs	841	20	cell	cell	NN
cord-296347-fanlvxqs	841	21	GEF	gef	NN
cord-296347-fanlvxqs	841	22	for	for	IN
cord-296347-fanlvxqs	841	23	the	the	DT
cord-296347-fanlvxqs	841	24	small	small	JJ
cord-296347-fanlvxqs	841	25	Rho	rho	NN
cord-296347-fanlvxqs	841	26	GTPases	GTPases	NNP
cord-296347-fanlvxqs	841	27	Cdc42	Cdc42	NNP
cord-296347-fanlvxqs	841	28	and	and	CC
cord-296347-fanlvxqs	841	29	Rac1	Rac1	NNP
cord-296347-fanlvxqs	841	30	,	,	,
cord-296347-fanlvxqs	841	31	involved	involve	VBN
cord-296347-fanlvxqs	841	32	in	in	IN
cord-296347-fanlvxqs	841	33	actin	actin	NN
cord-296347-fanlvxqs	841	34	remodeling	remodeling	NN
cord-296347-fanlvxqs	841	35	and	and	CC
cord-296347-fanlvxqs	841	36	formation	formation	NN
cord-296347-fanlvxqs	841	37	of	of	IN
cord-296347-fanlvxqs	841	38	membrane	membrane	NN
cord-296347-fanlvxqs	841	39	extensions	extension	NNS
cord-296347-fanlvxqs	841	40	required	require	VBN
cord-296347-fanlvxqs	841	41	for	for	IN
cord-296347-fanlvxqs	841	42	bacterial	bacterial	JJ
cord-296347-fanlvxqs	841	43	engulfment	engulfment	NN
cord-296347-fanlvxqs	841	44	.	.	.
cord-296347-fanlvxqs	842	1	SptP	SptP	NNP
cord-296347-fanlvxqs	842	2	,	,	,
cord-296347-fanlvxqs	842	3	delivered	deliver	VBN
cord-296347-fanlvxqs	842	4	by	by	IN
cord-296347-fanlvxqs	842	5	another	another	DT
cord-296347-fanlvxqs	842	6	TTSS	TTSS	NNP
cord-296347-fanlvxqs	842	7	,	,	,
cord-296347-fanlvxqs	842	8	is	be	VBZ
cord-296347-fanlvxqs	842	9	a	a	DT
cord-296347-fanlvxqs	842	10	Rho	Rho	NNP
cord-296347-fanlvxqs	842	11	GTPase	GTPase	NNP
cord-296347-fanlvxqs	842	12	activating	activate	VBG
cord-296347-fanlvxqs	842	13	protein	protein	NN
cord-296347-fanlvxqs	842	14	(	(	-LRB-
cord-296347-fanlvxqs	842	15	GAP	gap	NN
cord-296347-fanlvxqs	842	16	)	)	-RRB-
cord-296347-fanlvxqs	842	17	factor	factor	NN
cord-296347-fanlvxqs	842	18	for	for	IN
cord-296347-fanlvxqs	842	19	Cdc42	Cdc42	NNP
cord-296347-fanlvxqs	842	20	and	and	CC
cord-296347-fanlvxqs	842	21	Rac1	Rac1	NNP
cord-296347-fanlvxqs	842	22	,	,	,
cord-296347-fanlvxqs	842	23	which	which	WDT
cord-296347-fanlvxqs	842	24	accelerates	accelerate	VBZ
cord-296347-fanlvxqs	842	25	GTP	GTP	NNP
cord-296347-fanlvxqs	842	26	hydrolysis	hydrolysis	NN
cord-296347-fanlvxqs	842	27	.	.	.
cord-296347-fanlvxqs	843	1	SpT	SpT	NNP
cord-296347-fanlvxqs	843	2	plays	play	VBZ
cord-296347-fanlvxqs	843	3	a	a	DT
cord-296347-fanlvxqs	843	4	role	role	NN
cord-296347-fanlvxqs	843	5	once	once	IN
cord-296347-fanlvxqs	843	6	bacterial	bacterial	JJ
cord-296347-fanlvxqs	843	7	internalization	internalization	NN
cord-296347-fanlvxqs	843	8	has	have	VBZ
cord-296347-fanlvxqs	843	9	taken	take	VBN
cord-296347-fanlvxqs	843	10	place	place	NN
cord-296347-fanlvxqs	843	11	,	,	,
cord-296347-fanlvxqs	843	12	inactivating	inactivate	VBG
cord-296347-fanlvxqs	843	13	the	the	DT
cord-296347-fanlvxqs	843	14	Rho	Rho	NNP
cord-296347-fanlvxqs	843	15	GTPases	gtpase	NNS
cord-296347-fanlvxqs	843	16	,	,	,
cord-296347-fanlvxqs	843	17	inhibiting	inhibit	VBG
cord-296347-fanlvxqs	843	18	actin	actin	JJ
cord-296347-fanlvxqs	843	19	polimerization	polimerization	NN
cord-296347-fanlvxqs	843	20	,	,	,
cord-296347-fanlvxqs	843	21	and	and	CC
cord-296347-fanlvxqs	843	22	assuring	assure	VBG
cord-296347-fanlvxqs	843	23	closure	closure	NN
cord-296347-fanlvxqs	843	24	of	of	IN
cord-296347-fanlvxqs	843	25	the	the	DT
cord-296347-fanlvxqs	843	26	plasma	plasma	NN
cord-296347-fanlvxqs	843	27	membrane	membrane	NN
cord-296347-fanlvxqs	843	28	and	and	CC
cord-296347-fanlvxqs	843	29	recovery	recovery	NN
cord-296347-fanlvxqs	843	30	of	of	IN
cord-296347-fanlvxqs	843	31	the	the	DT
cord-296347-fanlvxqs	843	32	normal	normal	JJ
cord-296347-fanlvxqs	843	33	cellular	cellular	JJ
cord-296347-fanlvxqs	843	34	architecture	architecture	NN
cord-296347-fanlvxqs	843	35	(	(	-LRB-
cord-296347-fanlvxqs	843	36	Pizarro	Pizarro	NNP
cord-296347-fanlvxqs	843	37	-	-	HYPH
cord-296347-fanlvxqs	843	38	Cerda	Cerda	NNP
cord-296347-fanlvxqs	843	39	and	and	CC
cord-296347-fanlvxqs	843	40	Cossart	Cossart	NNP
cord-296347-fanlvxqs	843	41	,	,	,
cord-296347-fanlvxqs	843	42	2006	2006	CD
cord-296347-fanlvxqs	843	43	)	)	-RRB-
cord-296347-fanlvxqs	843	44	.	.	.
cord-296347-fanlvxqs	844	1	Salmonella	salmonella	NN
cord-296347-fanlvxqs	844	2	initially	initially	RB
cord-296347-fanlvxqs	844	3	delivers	deliver	VBZ
cord-296347-fanlvxqs	844	4	equal	equal	JJ
cord-296347-fanlvxqs	844	5	amounts	amount	NNS
cord-296347-fanlvxqs	844	6	of	of	IN
cord-296347-fanlvxqs	844	7	SopE	SopE	NNP
cord-296347-fanlvxqs	844	8	and	and	CC
cord-296347-fanlvxqs	844	9	SptB	SptB	NNP
cord-296347-fanlvxqs	844	10	to	to	IN
cord-296347-fanlvxqs	844	11	the	the	DT
cord-296347-fanlvxqs	844	12	host	host	NN
cord-296347-fanlvxqs	844	13	cell	cell	NN
cord-296347-fanlvxqs	844	14	.	.	.
cord-296347-fanlvxqs	845	1	However	however	RB
cord-296347-fanlvxqs	845	2	,	,	,
cord-296347-fanlvxqs	845	3	15	15	CD
cord-296347-fanlvxqs	845	4	-	-	SYM
cord-296347-fanlvxqs	845	5	20	20	CD
cord-296347-fanlvxqs	845	6	min	min	NN
cord-296347-fanlvxqs	845	7	after	after	IN
cord-296347-fanlvxqs	845	8	infection	infection	NN
cord-296347-fanlvxqs	845	9	SopE	SopE	NNP
cord-296347-fanlvxqs	845	10	is	be	VBZ
cord-296347-fanlvxqs	845	11	rapidly	rapidly	RB
cord-296347-fanlvxqs	845	12	degraded	degrade	VBN
cord-296347-fanlvxqs	845	13	,	,	,
cord-296347-fanlvxqs	845	14	whereas	whereas	IN
cord-296347-fanlvxqs	845	15	SptB	SptB	NNP
cord-296347-fanlvxqs	845	16	degradation	degradation	NN
cord-296347-fanlvxqs	845	17	occurs	occur	VBZ
cord-296347-fanlvxqs	845	18	only	only	RB
cord-296347-fanlvxqs	845	19	slowly	slowly	RB
cord-296347-fanlvxqs	845	20	after	after	IN
cord-296347-fanlvxqs	845	21	3	3	CD
cord-296347-fanlvxqs	845	22	h	h	NN
cord-296347-fanlvxqs	845	23	,	,	,
cord-296347-fanlvxqs	845	24	thereby	thereby	RB
cord-296347-fanlvxqs	845	25	efficiently	efficiently	RB
cord-296347-fanlvxqs	845	26	timing	time	VBG
cord-296347-fanlvxqs	845	27	the	the	DT
cord-296347-fanlvxqs	845	28	actin	actin	NN
cord-296347-fanlvxqs	845	29	remodeling	remodeling	NN
cord-296347-fanlvxqs	845	30	events	event	NNS
cord-296347-fanlvxqs	845	31	that	that	WDT
cord-296347-fanlvxqs	845	32	lead	lead	VBP
cord-296347-fanlvxqs	845	33	to	to	IN
cord-296347-fanlvxqs	845	34	the	the	DT
cord-296347-fanlvxqs	845	35	initial	initial	JJ
cord-296347-fanlvxqs	845	36	bacterial	bacterial	JJ
cord-296347-fanlvxqs	845	37	engulfment	engulfment	NN
cord-296347-fanlvxqs	845	38	and	and	CC
cord-296347-fanlvxqs	845	39	the	the	DT
cord-296347-fanlvxqs	845	40	later	later	JJ
cord-296347-fanlvxqs	845	41	host	host	NN
cord-296347-fanlvxqs	845	42	cell	cell	NN
cord-296347-fanlvxqs	845	43	recovery	recovery	NN
cord-296347-fanlvxqs	845	44	.	.	.
cord-296347-fanlvxqs	846	1	Both	both	DT
cord-296347-fanlvxqs	846	2	processes	process	NNS
cord-296347-fanlvxqs	846	3	are	be	VBP
cord-296347-fanlvxqs	846	4	proteasome	proteasome	VBN
cord-296347-fanlvxqs	846	5	-	-	HYPH
cord-296347-fanlvxqs	846	6	dependent	dependent	JJ
cord-296347-fanlvxqs	846	7	and	and	CC
cord-296347-fanlvxqs	846	8	catalyzed	catalyze	VBN
cord-296347-fanlvxqs	846	9	by	by	IN
cord-296347-fanlvxqs	846	10	the	the	DT
cord-296347-fanlvxqs	846	11	N	n	CD
cord-296347-fanlvxqs	846	12	-	-	HYPH
cord-296347-fanlvxqs	846	13	terminus	terminus	NN
cord-296347-fanlvxqs	846	14	of	of	IN
cord-296347-fanlvxqs	846	15	the	the	DT
cord-296347-fanlvxqs	846	16	bacterial	bacterial	JJ
cord-296347-fanlvxqs	846	17	proteins	protein	NNS
cord-296347-fanlvxqs	846	18	,	,	,
cord-296347-fanlvxqs	846	19	but	but	CC
cord-296347-fanlvxqs	846	20	the	the	DT
cord-296347-fanlvxqs	846	21	mechanism	mechanism	NN
cord-296347-fanlvxqs	846	22	and	and	CC
cord-296347-fanlvxqs	846	23	the	the	DT
cord-296347-fanlvxqs	846	24	host	host	NN
cord-296347-fanlvxqs	846	25	factors	factor	NNS
cord-296347-fanlvxqs	846	26	involved	involve	VBN
cord-296347-fanlvxqs	846	27	are	be	VBP
cord-296347-fanlvxqs	846	28	currently	currently	RB
cord-296347-fanlvxqs	846	29	unknown	unknown	JJ
cord-296347-fanlvxqs	847	1	(	(	-LRB-
cord-296347-fanlvxqs	847	2	Kubori	Kubori	NNP
cord-296347-fanlvxqs	847	3	and	and	CC
cord-296347-fanlvxqs	847	4	Galan	Galan	NNP
cord-296347-fanlvxqs	847	5	,	,	,
cord-296347-fanlvxqs	847	6	2003	2003	CD
cord-296347-fanlvxqs	847	7	)	)	-RRB-
cord-296347-fanlvxqs	847	8	.	.	.
cord-296347-fanlvxqs	848	1	The	the	DT
cord-296347-fanlvxqs	848	2	HIV-1	HIV-1	NNP
cord-296347-fanlvxqs	848	3	Vif	Vif	NNP
cord-296347-fanlvxqs	848	4	protein	protein	NN
cord-296347-fanlvxqs	848	5	targets	target	VBZ
cord-296347-fanlvxqs	848	6	the	the	DT
cord-296347-fanlvxqs	848	7	RNA	RNA	NNP
cord-296347-fanlvxqs	848	8	editing	editing	NN
cord-296347-fanlvxqs	848	9	protein	protein	NN
cord-296347-fanlvxqs	848	10	APOBEC3	apobec3	NN
cord-296347-fanlvxqs	848	11	G	g	NN
cord-296347-fanlvxqs	848	12	for	for	IN
cord-296347-fanlvxqs	848	13	degradation	degradation	NN
cord-296347-fanlvxqs	848	14	by	by	IN
cord-296347-fanlvxqs	848	15	a	a	DT
cord-296347-fanlvxqs	848	16	cellular	cellular	JJ
cord-296347-fanlvxqs	848	17	E3	e3	NN
cord-296347-fanlvxqs	848	18	ligase	ligase	NN
cord-296347-fanlvxqs	848	19	to	to	TO
cord-296347-fanlvxqs	848	20	allow	allow	VB
cord-296347-fanlvxqs	848	21	production	production	NN
cord-296347-fanlvxqs	848	22	of	of	IN
cord-296347-fanlvxqs	848	23	infectious	infectious	JJ
cord-296347-fanlvxqs	848	24	viral	viral	JJ
cord-296347-fanlvxqs	848	25	progeny	progeny	NN
cord-296347-fanlvxqs	849	1	(	(	-LRB-
cord-296347-fanlvxqs	849	2	Yu	Yu	NNP
cord-296347-fanlvxqs	849	3	et	et	FW
cord-296347-fanlvxqs	849	4	al	al	NNP
cord-296347-fanlvxqs	849	5	.	.	NNP
cord-296347-fanlvxqs	849	6	,	,	,
cord-296347-fanlvxqs	849	7	2003	2003	CD
cord-296347-fanlvxqs	849	8	)	)	-RRB-
cord-296347-fanlvxqs	849	9	.	.	.
cord-296347-fanlvxqs	850	1	The	the	DT
cord-296347-fanlvxqs	850	2	apolipoprotein	apolipoprotein	NN
cord-296347-fanlvxqs	850	3	B	B	NNP
cord-296347-fanlvxqs	850	4	mRNA	mrna	NN
cord-296347-fanlvxqs	850	5	editing	editing	NN
cord-296347-fanlvxqs	850	6	enzyme	enzyme	NN
cord-296347-fanlvxqs	850	7	,	,	,
cord-296347-fanlvxqs	850	8	catalytic	catalytic	JJ
cord-296347-fanlvxqs	850	9	polypeptide	polypeptide	NN
cord-296347-fanlvxqs	850	10	-	-	:
cord-296347-fanlvxqs	850	11	like	like	JJ
cord-296347-fanlvxqs	850	12	3	3	CD
cord-296347-fanlvxqs	850	13	G	g	NN
cord-296347-fanlvxqs	850	14	(	(	-LRB-
cord-296347-fanlvxqs	850	15	APOBEC3	APOBEC3	NNP
cord-296347-fanlvxqs	850	16	G	g	NN
cord-296347-fanlvxqs	850	17	)	)	-RRB-
cord-296347-fanlvxqs	850	18	and	and	CC
cord-296347-fanlvxqs	850	19	related	relate	VBN
cord-296347-fanlvxqs	850	20	cytidine	cytidine	NNP
cord-296347-fanlvxqs	850	21	deaminases	deaminase	NNS
cord-296347-fanlvxqs	850	22	are	be	VBP
cord-296347-fanlvxqs	850	23	involved	involve	VBN
cord-296347-fanlvxqs	850	24	in	in	IN
cord-296347-fanlvxqs	850	25	mRNA	mRNA	NNP
cord-296347-fanlvxqs	850	26	editing	editing	NN
cord-296347-fanlvxqs	850	27	and	and	CC
cord-296347-fanlvxqs	850	28	in	in	IN
cord-296347-fanlvxqs	850	29	immunoglobulin	immunoglobulin	NN
cord-296347-fanlvxqs	850	30	gene	gene	NN
cord-296347-fanlvxqs	850	31	class	class	NN
cord-296347-fanlvxqs	850	32	switching	switching	NN
cord-296347-fanlvxqs	850	33	and	and	CC
cord-296347-fanlvxqs	850	34	hypermutation	hypermutation	NN
cord-296347-fanlvxqs	850	35	but	but	CC
cord-296347-fanlvxqs	850	36	are	be	VBP
cord-296347-fanlvxqs	850	37	also	also	RB
cord-296347-fanlvxqs	850	38	potent	potent	JJ
cord-296347-fanlvxqs	850	39	antiretroviral	antiretroviral	JJ
cord-296347-fanlvxqs	850	40	enzymes	enzyme	NNS
cord-296347-fanlvxqs	850	41	.	.	.
cord-296347-fanlvxqs	851	1	The	the	DT
cord-296347-fanlvxqs	851	2	cytosolic	cytosolic	JJ
cord-296347-fanlvxqs	851	3	APO	APO	NNP
cord-296347-fanlvxqs	851	4	-	-	HYPH
cord-296347-fanlvxqs	851	5	BEC3	BEC3	NNP
cord-296347-fanlvxqs	851	6	G	G	NNP
cord-296347-fanlvxqs	851	7	is	be	VBZ
cord-296347-fanlvxqs	851	8	incorporated	incorporate	VBN
cord-296347-fanlvxqs	851	9	into	into	IN
cord-296347-fanlvxqs	851	10	budding	bud	VBG
cord-296347-fanlvxqs	851	11	virions	virion	NNS
cord-296347-fanlvxqs	851	12	,	,	,
cord-296347-fanlvxqs	851	13	where	where	WRB
cord-296347-fanlvxqs	851	14	on	on	IN
cord-296347-fanlvxqs	851	15	infection	infection	NN
cord-296347-fanlvxqs	851	16	of	of	IN
cord-296347-fanlvxqs	851	17	new	new	JJ
cord-296347-fanlvxqs	851	18	target	target	NN
cord-296347-fanlvxqs	851	19	cells	cell	NNS
cord-296347-fanlvxqs	851	20	,	,	,
cord-296347-fanlvxqs	851	21	its	-PRON-	PRP$
cord-296347-fanlvxqs	851	22	cytidine	cytidine	NN
cord-296347-fanlvxqs	851	23	deaminase	deaminase	NN
cord-296347-fanlvxqs	851	24	activity	activity	NN
cord-296347-fanlvxqs	851	25	induces	induce	VBZ
cord-296347-fanlvxqs	851	26	G	g	NN
cord-296347-fanlvxqs	851	27	to	to	IN
cord-296347-fanlvxqs	851	28	A	a	DT
cord-296347-fanlvxqs	851	29	hypermutation	hypermutation	NN
cord-296347-fanlvxqs	851	30	on	on	IN
cord-296347-fanlvxqs	851	31	the	the	DT
cord-296347-fanlvxqs	851	32	minus	minus	JJ
cord-296347-fanlvxqs	851	33	-	-	HYPH
cord-296347-fanlvxqs	851	34	strand	strand	NN
cord-296347-fanlvxqs	851	35	viral	viral	JJ
cord-296347-fanlvxqs	851	36	DNA	dna	NN
cord-296347-fanlvxqs	851	37	,	,	,
cord-296347-fanlvxqs	851	38	resulting	result	VBG
cord-296347-fanlvxqs	851	39	in	in	IN
cord-296347-fanlvxqs	851	40	abortive	abortive	JJ
cord-296347-fanlvxqs	851	41	infection	infection	NN
cord-296347-fanlvxqs	851	42	(	(	-LRB-
cord-296347-fanlvxqs	851	43	Bishop	Bishop	NNP
cord-296347-fanlvxqs	851	44	et	et	NNP
cord-296347-fanlvxqs	851	45	al	al	NNP
cord-296347-fanlvxqs	851	46	.	.	.
cord-296347-fanlvxqs	852	1	,	,	,
cord-296347-fanlvxqs	852	2	2004b	2004b	CD
cord-296347-fanlvxqs	852	3	;	;	:
cord-296347-fanlvxqs	852	4	Zhang	Zhang	NNP
cord-296347-fanlvxqs	852	5	et	et	NNP
cord-296347-fanlvxqs	852	6	al	al	NNP
cord-296347-fanlvxqs	852	7	.	.	NNP
cord-296347-fanlvxqs	852	8	,	,	,
cord-296347-fanlvxqs	852	9	2003	2003	CD
cord-296347-fanlvxqs	852	10	)	)	-RRB-
cord-296347-fanlvxqs	852	11	.	.	.
cord-296347-fanlvxqs	853	1	Vif	Vif	NNP
cord-296347-fanlvxqs	853	2	hijacks	hijack	VBZ
cord-296347-fanlvxqs	853	3	the	the	DT
cord-296347-fanlvxqs	853	4	elongin	elongin	NNP
cord-296347-fanlvxqs	853	5	-	-	HYPH
cord-296347-fanlvxqs	853	6	C	C	NNP
cord-296347-fanlvxqs	853	7	-	-	HYPH
cord-296347-fanlvxqs	853	8	elongin	elongin	NN
cord-296347-fanlvxqs	853	9	-	-	HYPH
cord-296347-fanlvxqs	853	10	B	B	NNP
cord-296347-fanlvxqs	853	11	-	-	HYPH
cord-296347-fanlvxqs	853	12	Cullin-5-E3	Cullin-5-E3	NNP
cord-296347-fanlvxqs	853	13	(	(	-LRB-
cord-296347-fanlvxqs	853	14	ECS	ECS	NNP
cord-296347-fanlvxqs	853	15	)	)	-RRB-
cord-296347-fanlvxqs	853	16	complex	complex	NNP
cord-296347-fanlvxqs	853	17	.	.	.
cord-296347-fanlvxqs	854	1	The	the	DT
cord-296347-fanlvxqs	854	2	ECS5	ECS5	NNP
cord-296347-fanlvxqs	854	3	E3s	e3s	TO
cord-296347-fanlvxqs	854	4	recognize	recognize	VB
cord-296347-fanlvxqs	854	5	substrate	substrate	NN
cord-296347-fanlvxqs	854	6	receptor	receptor	NN
cord-296347-fanlvxqs	854	7	proteins	protein	NNS
cord-296347-fanlvxqs	854	8	containing	contain	VBG
cord-296347-fanlvxqs	854	9	a	a	DT
cord-296347-fanlvxqs	854	10	BC	BC	NNP
cord-296347-fanlvxqs	854	11	-	-	HYPH
cord-296347-fanlvxqs	854	12	box	box	NN
cord-296347-fanlvxqs	854	13	.	.	.
cord-296347-fanlvxqs	855	1	Vif	Vif	NNP
cord-296347-fanlvxqs	855	2	possesses	possess	VBZ
cord-296347-fanlvxqs	855	3	a	a	DT
cord-296347-fanlvxqs	855	4	BC	BC	NNP
cord-296347-fanlvxqs	855	5	-	-	HYPH
cord-296347-fanlvxqs	855	6	box	box	NN
cord-296347-fanlvxqs	855	7	motif	motif	NN
cord-296347-fanlvxqs	855	8	,	,	,
cord-296347-fanlvxqs	855	9	through	through	IN
cord-296347-fanlvxqs	855	10	which	which	WDT
cord-296347-fanlvxqs	855	11	it	-PRON-	PRP
cord-296347-fanlvxqs	855	12	binds	bind	VBZ
cord-296347-fanlvxqs	855	13	elongin	elongin	NNP
cord-296347-fanlvxqs	855	14	C	C	NNP
cord-296347-fanlvxqs	855	15	.	.	.
cord-296347-fanlvxqs	856	1	Vif	Vif	NNP
cord-296347-fanlvxqs	856	2	hijacks	hijack	VBZ
cord-296347-fanlvxqs	856	3	the	the	DT
cord-296347-fanlvxqs	856	4	E3	e3	NN
cord-296347-fanlvxqs	856	5	ligase	ligase	NN
cord-296347-fanlvxqs	856	6	complex	complex	NN
cord-296347-fanlvxqs	856	7	and	and	CC
cord-296347-fanlvxqs	856	8	by	by	IN
cord-296347-fanlvxqs	856	9	bridging	bridge	VBG
cord-296347-fanlvxqs	856	10	APOBEC3	APOBEC3	NNP
cord-296347-fanlvxqs	856	11	G	G	NNP
cord-296347-fanlvxqs	856	12	and	and	CC
cord-296347-fanlvxqs	856	13	elongin	elongin	NNP
cord-296347-fanlvxqs	856	14	C	C	NNP
cord-296347-fanlvxqs	856	15	targets	target	VBZ
cord-296347-fanlvxqs	856	16	APOBEC3	apobec3	DT
cord-296347-fanlvxqs	856	17	G	g	NN
cord-296347-fanlvxqs	856	18	for	for	IN
cord-296347-fanlvxqs	856	19	ubiquitination	ubiquitination	NN
cord-296347-fanlvxqs	856	20	and	and	CC
cord-296347-fanlvxqs	856	21	degradation	degradation	NN
cord-296347-fanlvxqs	856	22	(	(	-LRB-
cord-296347-fanlvxqs	856	23	Yu	Yu	NNP
cord-296347-fanlvxqs	856	24	et	et	FW
cord-296347-fanlvxqs	856	25	al	al	NNP
cord-296347-fanlvxqs	856	26	.	.	NNP
cord-296347-fanlvxqs	856	27	,	,	,
cord-296347-fanlvxqs	856	28	2003	2003	CD
cord-296347-fanlvxqs	856	29	)	)	-RRB-
cord-296347-fanlvxqs	856	30	.	.	.
cord-296347-fanlvxqs	857	1	This	this	DT
cord-296347-fanlvxqs	857	2	ultimately	ultimately	RB
cord-296347-fanlvxqs	857	3	allows	allow	VBZ
cord-296347-fanlvxqs	857	4	production	production	NN
cord-296347-fanlvxqs	857	5	of	of	IN
cord-296347-fanlvxqs	857	6	infectious	infectious	JJ
cord-296347-fanlvxqs	857	7	virus	virus	NN
cord-296347-fanlvxqs	857	8	progeny	progeny	NN
cord-296347-fanlvxqs	857	9	(	(	-LRB-
cord-296347-fanlvxqs	857	10	Bieniasz	Bieniasz	NNP
cord-296347-fanlvxqs	857	11	,	,	,
cord-296347-fanlvxqs	857	12	2004	2004	CD
cord-296347-fanlvxqs	857	13	;	;	:
cord-296347-fanlvxqs	858	1	Bishop	Bishop	NNP
cord-296347-fanlvxqs	858	2	et	et	NNP
cord-296347-fanlvxqs	858	3	al	al	NNP
cord-296347-fanlvxqs	858	4	.	.	NNP
cord-296347-fanlvxqs	858	5	,	,	,
cord-296347-fanlvxqs	858	6	2004a	2004a	CD
cord-296347-fanlvxqs	858	7	;	;	:
cord-296347-fanlvxqs	858	8	Harris	Harris	NNP
cord-296347-fanlvxqs	858	9	and	and	CC
cord-296347-fanlvxqs	858	10	Liddament	Liddament	NNP
cord-296347-fanlvxqs	858	11	,	,	,
cord-296347-fanlvxqs	858	12	2004	2004	CD
cord-296347-fanlvxqs	858	13	)	)	-RRB-
cord-296347-fanlvxqs	858	14	.	.	.
cord-296347-fanlvxqs	859	1	The	the	DT
cord-296347-fanlvxqs	859	2	endosomal	endosomal	JJ
cord-296347-fanlvxqs	859	3	sorting	sorting	NN
cord-296347-fanlvxqs	859	4	complexes	complex	NNS
cord-296347-fanlvxqs	859	5	required	require	VBN
cord-296347-fanlvxqs	859	6	for	for	IN
cord-296347-fanlvxqs	859	7	transport	transport	NN
cord-296347-fanlvxqs	859	8	(	(	-LRB-
cord-296347-fanlvxqs	859	9	ESCRT	ESCRT	NNP
cord-296347-fanlvxqs	859	10	)	)	-RRB-
cord-296347-fanlvxqs	859	11	are	be	VBP
cord-296347-fanlvxqs	859	12	highly	highly	RB
cord-296347-fanlvxqs	859	13	conserved	conserve	VBN
cord-296347-fanlvxqs	859	14	from	from	IN
cord-296347-fanlvxqs	859	15	yeast	yeast	NN
cord-296347-fanlvxqs	859	16	to	to	IN
cord-296347-fanlvxqs	859	17	mammals	mammal	NNS
cord-296347-fanlvxqs	859	18	and	and	CC
cord-296347-fanlvxqs	859	19	consist	consist	VBP
cord-296347-fanlvxqs	859	20	of	of	IN
cord-296347-fanlvxqs	859	21	the	the	DT
cord-296347-fanlvxqs	859	22	ESCRT	ESCRT	NNP
cord-296347-fanlvxqs	859	23	I	-PRON-	PRP
cord-296347-fanlvxqs	859	24	,	,	,
cord-296347-fanlvxqs	859	25	II	II	NNP
cord-296347-fanlvxqs	859	26	,	,	,
cord-296347-fanlvxqs	859	27	and	and	CC
cord-296347-fanlvxqs	859	28	III	iii	CD
cord-296347-fanlvxqs	859	29	complexes	complex	NNS
cord-296347-fanlvxqs	859	30	.	.	.
cord-296347-fanlvxqs	860	1	ESCRT	ESCRT	NNP
cord-296347-fanlvxqs	860	2	complexes	complex	NNS
cord-296347-fanlvxqs	860	3	are	be	VBP
cord-296347-fanlvxqs	860	4	composed	compose	VBN
cord-296347-fanlvxqs	860	5	of	of	IN
cord-296347-fanlvxqs	860	6	vacuolar	vacuolar	NNP
cord-296347-fanlvxqs	860	7	protein	protein	NN
cord-296347-fanlvxqs	860	8	sorting	sorting	NN
cord-296347-fanlvxqs	860	9	(	(	-LRB-
cord-296347-fanlvxqs	860	10	VPS	VPS	NNP
cord-296347-fanlvxqs	860	11	)	)	-RRB-
cord-296347-fanlvxqs	860	12	proteins	protein	NNS
cord-296347-fanlvxqs	860	13	(	(	-LRB-
cord-296347-fanlvxqs	860	14	in	in	IN
cord-296347-fanlvxqs	860	15	yeast	yeast	NN
cord-296347-fanlvxqs	860	16	)	)	-RRB-
cord-296347-fanlvxqs	860	17	,	,	,
cord-296347-fanlvxqs	860	18	which	which	WDT
cord-296347-fanlvxqs	860	19	are	be	VBP
cord-296347-fanlvxqs	860	20	recruited	recruit	VBN
cord-296347-fanlvxqs	860	21	from	from	IN
cord-296347-fanlvxqs	860	22	the	the	DT
cord-296347-fanlvxqs	860	23	cytoplasm	cytoplasm	NN
cord-296347-fanlvxqs	860	24	to	to	TO
cord-296347-fanlvxqs	860	25	promote	promote	VB
cord-296347-fanlvxqs	860	26	sorting	sorting	NN
cord-296347-fanlvxqs	860	27	of	of	IN
cord-296347-fanlvxqs	860	28	ubiquitinated	ubiquitinated	JJ
cord-296347-fanlvxqs	860	29	proteins	protein	NNS
cord-296347-fanlvxqs	860	30	to	to	IN
cord-296347-fanlvxqs	860	31	MVBs	MVBs	NNP
cord-296347-fanlvxqs	860	32	(	(	-LRB-
cord-296347-fanlvxqs	860	33	Katzmann	Katzmann	NNP
cord-296347-fanlvxqs	860	34	et	et	NNP
cord-296347-fanlvxqs	860	35	al	al	NNP
cord-296347-fanlvxqs	860	36	.	.	NNP
cord-296347-fanlvxqs	860	37	,	,	,
cord-296347-fanlvxqs	860	38	2002	2002	CD
cord-296347-fanlvxqs	860	39	)	)	-RRB-
cord-296347-fanlvxqs	860	40	.	.	.
cord-296347-fanlvxqs	861	1	MVBs	mvb	NNS
cord-296347-fanlvxqs	861	2	are	be	VBP
cord-296347-fanlvxqs	861	3	formed	form	VBN
cord-296347-fanlvxqs	861	4	by	by	IN
cord-296347-fanlvxqs	861	5	invagination	invagination	NN
cord-296347-fanlvxqs	861	6	of	of	IN
cord-296347-fanlvxqs	861	7	the	the	DT
cord-296347-fanlvxqs	861	8	late	late	JJ
cord-296347-fanlvxqs	861	9	endosome	endosome	NN
cord-296347-fanlvxqs	861	10	membrane	membrane	NN
cord-296347-fanlvxqs	861	11	,	,	,
cord-296347-fanlvxqs	861	12	which	which	WDT
cord-296347-fanlvxqs	861	13	generates	generate	VBZ
cord-296347-fanlvxqs	861	14	internal	internal	JJ
cord-296347-fanlvxqs	861	15	vesicles	vesicle	NNS
cord-296347-fanlvxqs	861	16	into	into	IN
cord-296347-fanlvxqs	861	17	which	which	WDT
cord-296347-fanlvxqs	861	18	proteins	protein	NNS
cord-296347-fanlvxqs	861	19	destined	destine	VBN
cord-296347-fanlvxqs	861	20	to	to	IN
cord-296347-fanlvxqs	861	21	the	the	DT
cord-296347-fanlvxqs	861	22	lysosomes	lysosome	NNS
cord-296347-fanlvxqs	861	23	are	be	VBP
cord-296347-fanlvxqs	861	24	sorted	sort	VBN
cord-296347-fanlvxqs	861	25	;	;	:
cord-296347-fanlvxqs	861	26	they	-PRON-	PRP
cord-296347-fanlvxqs	861	27	are	be	VBP
cord-296347-fanlvxqs	861	28	critical	critical	JJ
cord-296347-fanlvxqs	861	29	for	for	IN
cord-296347-fanlvxqs	861	30	receptor	receptor	NN
cord-296347-fanlvxqs	861	31	downregulation	downregulation	NN
cord-296347-fanlvxqs	861	32	and	and	CC
cord-296347-fanlvxqs	861	33	other	other	JJ
cord-296347-fanlvxqs	861	34	normal	normal	JJ
cord-296347-fanlvxqs	861	35	and	and	CC
cord-296347-fanlvxqs	861	36	pathological	pathological	JJ
cord-296347-fanlvxqs	861	37	cell	cell	NN
cord-296347-fanlvxqs	861	38	processes	process	NNS
cord-296347-fanlvxqs	861	39	(	(	-LRB-
cord-296347-fanlvxqs	861	40	Hierro	Hierro	NNP
cord-296347-fanlvxqs	861	41	et	et	NNP
cord-296347-fanlvxqs	861	42	al	al	NNP
cord-296347-fanlvxqs	861	43	.	.	.
cord-296347-fanlvxqs	862	1	,	,	,
cord-296347-fanlvxqs	862	2	2004	2004	CD
cord-296347-fanlvxqs	862	3	;	;	:
cord-296347-fanlvxqs	862	4	Hurley	Hurley	NNP
cord-296347-fanlvxqs	862	5	and	and	CC
cord-296347-fanlvxqs	862	6	Emr	Emr	NNP
cord-296347-fanlvxqs	862	7	,	,	,
cord-296347-fanlvxqs	862	8	2006	2006	CD
cord-296347-fanlvxqs	862	9	;	;	:
cord-296347-fanlvxqs	862	10	Kostelansky	Kostelansky	NNP
cord-296347-fanlvxqs	862	11	et	et	NNP
cord-296347-fanlvxqs	862	12	al	al	NNP
cord-296347-fanlvxqs	862	13	.	.	NNP
cord-296347-fanlvxqs	862	14	,	,	,
cord-296347-fanlvxqs	862	15	2006	2006	CD
cord-296347-fanlvxqs	862	16	)	)	-RRB-
cord-296347-fanlvxqs	862	17	,	,	,
cord-296347-fanlvxqs	862	18	as	as	RB
cord-296347-fanlvxqs	862	19	well	well	RB
cord-296347-fanlvxqs	862	20	as	as	IN
cord-296347-fanlvxqs	862	21	for	for	IN
cord-296347-fanlvxqs	862	22	virus	virus	NN
cord-296347-fanlvxqs	862	23	budding	bud	VBG
cord-296347-fanlvxqs	862	24	.	.	.
cord-296347-fanlvxqs	863	1	The	the	DT
cord-296347-fanlvxqs	863	2	tumor	tumor	NN
cord-296347-fanlvxqs	863	3	susceptibility	susceptibility	NN
cord-296347-fanlvxqs	863	4	gene	gene	NN
cord-296347-fanlvxqs	863	5	TSG101	TSG101	NNP
cord-296347-fanlvxqs	863	6	,	,	,
cord-296347-fanlvxqs	863	7	the	the	DT
cord-296347-fanlvxqs	863	8	mammalian	mammalian	JJ
cord-296347-fanlvxqs	863	9	homologue	homologue	NN
cord-296347-fanlvxqs	863	10	of	of	IN
cord-296347-fanlvxqs	863	11	yeast	yeast	NN
cord-296347-fanlvxqs	863	12	VPS23	VPS23	NNP
cord-296347-fanlvxqs	863	13	,	,	,
cord-296347-fanlvxqs	863	14	is	be	VBZ
cord-296347-fanlvxqs	863	15	essential	essential	JJ
cord-296347-fanlvxqs	863	16	for	for	IN
cord-296347-fanlvxqs	863	17	sorting	sorting	NN
cord-296347-fanlvxqs	863	18	of	of	IN
cord-296347-fanlvxqs	863	19	ubiquitinated	ubiquitinated	JJ
cord-296347-fanlvxqs	863	20	proteins	protein	NNS
cord-296347-fanlvxqs	863	21	to	to	IN
cord-296347-fanlvxqs	863	22	MVBs	mvb	NNS
cord-296347-fanlvxqs	863	23	(	(	-LRB-
cord-296347-fanlvxqs	863	24	Babst	Babst	NNP
cord-296347-fanlvxqs	863	25	et	et	NNP
cord-296347-fanlvxqs	863	26	al	al	NNP
cord-296347-fanlvxqs	863	27	.	.	NNP
cord-296347-fanlvxqs	863	28	,	,	,
cord-296347-fanlvxqs	863	29	2000	2000	CD
cord-296347-fanlvxqs	863	30	)	)	-RRB-
cord-296347-fanlvxqs	863	31	.	.	.
cord-296347-fanlvxqs	864	1	TSG101	TSG101	NNP
cord-296347-fanlvxqs	864	2	recruits	recruit	VBZ
cord-296347-fanlvxqs	864	3	hepatocyte	hepatocyte	VBP
cord-296347-fanlvxqs	864	4	growth	growth	NN
cord-296347-fanlvxqs	864	5	factor	factor	NN
cord-296347-fanlvxqs	864	6	-	-	HYPH
cord-296347-fanlvxqs	864	7	regulated	regulate	VBN
cord-296347-fanlvxqs	864	8	tyrosine	tyrosine	NN
cord-296347-fanlvxqs	864	9	kinase	kinase	NN
cord-296347-fanlvxqs	864	10	substrate	substrate	NN
cord-296347-fanlvxqs	864	11	(	(	-LRB-
cord-296347-fanlvxqs	864	12	HRS	HRS	NNP
cord-296347-fanlvxqs	864	13	)	)	-RRB-
cord-296347-fanlvxqs	864	14	,	,	,
cord-296347-fanlvxqs	864	15	the	the	DT
cord-296347-fanlvxqs	864	16	mammalian	mammalian	JJ
cord-296347-fanlvxqs	864	17	homologue	homologue	NN
cord-296347-fanlvxqs	864	18	of	of	IN
cord-296347-fanlvxqs	864	19	yeast	yeast	NN
cord-296347-fanlvxqs	864	20	VPS27	vps27	NN
cord-296347-fanlvxqs	864	21	,	,	,
cord-296347-fanlvxqs	864	22	to	to	IN
cord-296347-fanlvxqs	864	23	the	the	DT
cord-296347-fanlvxqs	864	24	endosomal	endosomal	NNP
cord-296347-fanlvxqs	864	25	membrane	membrane	NN
cord-296347-fanlvxqs	864	26	.	.	.
cord-296347-fanlvxqs	865	1	HRS	HRS	NNP
cord-296347-fanlvxqs	865	2	nucleates	nucleate	NNS
cord-296347-fanlvxqs	865	3	recruitment	recruitment	NN
cord-296347-fanlvxqs	865	4	of	of	IN
cord-296347-fanlvxqs	865	5	the	the	DT
cord-296347-fanlvxqs	865	6	ESCRT-1	ESCRT-1	NNP
cord-296347-fanlvxqs	865	7	complex	complex	NN
cord-296347-fanlvxqs	865	8	,	,	,
cord-296347-fanlvxqs	865	9	which	which	WDT
cord-296347-fanlvxqs	865	10	in	in	IN
cord-296347-fanlvxqs	865	11	turn	turn	NN
cord-296347-fanlvxqs	865	12	recruits	recruit	VBZ
cord-296347-fanlvxqs	865	13	ESCRT	ESCRT	NNP
cord-296347-fanlvxqs	865	14	2	2	CD
cord-296347-fanlvxqs	865	15	and	and	CC
cord-296347-fanlvxqs	865	16	-3	-3	NNP
cord-296347-fanlvxqs	865	17	,	,	,
cord-296347-fanlvxqs	865	18	leading	lead	VBG
cord-296347-fanlvxqs	865	19	to	to	IN
cord-296347-fanlvxqs	865	20	formation	formation	NN
cord-296347-fanlvxqs	865	21	of	of	IN
cord-296347-fanlvxqs	865	22	the	the	DT
cord-296347-fanlvxqs	865	23	inner	inner	JJ
cord-296347-fanlvxqs	865	24	membranes	membrane	NNS
cord-296347-fanlvxqs	865	25	of	of	IN
cord-296347-fanlvxqs	865	26	the	the	DT
cord-296347-fanlvxqs	865	27	MVB	MVB	NNP
cord-296347-fanlvxqs	865	28	.	.	.
cord-296347-fanlvxqs	866	1	TSG101	TSG101	NNP
cord-296347-fanlvxqs	866	2	is	be	VBZ
cord-296347-fanlvxqs	866	3	a	a	DT
cord-296347-fanlvxqs	866	4	noncanonical	noncanonical	JJ
cord-296347-fanlvxqs	866	5	Ub	Ub	NNP
cord-296347-fanlvxqs	866	6	E2	E2	NNP
cord-296347-fanlvxqs	866	7	variant	variant	NN
cord-296347-fanlvxqs	866	8	(	(	-LRB-
cord-296347-fanlvxqs	866	9	UEV	UEV	NNP
cord-296347-fanlvxqs	866	10	)	)	-RRB-
cord-296347-fanlvxqs	866	11	protein	protein	NN
cord-296347-fanlvxqs	866	12	-	-	:
cord-296347-fanlvxqs	866	13	it	-PRON-	PRP
cord-296347-fanlvxqs	866	14	does	do	VBZ
cord-296347-fanlvxqs	866	15	not	not	RB
cord-296347-fanlvxqs	866	16	possess	possess	VB
cord-296347-fanlvxqs	866	17	Ub	Ub	NNP
cord-296347-fanlvxqs	866	18	-	-	HYPH
cord-296347-fanlvxqs	866	19	conjugating	conjugate	VBG
cord-296347-fanlvxqs	866	20	activity	activity	NN
cord-296347-fanlvxqs	866	21	,	,	,
cord-296347-fanlvxqs	866	22	only	only	RB
cord-296347-fanlvxqs	866	23	an	an	DT
cord-296347-fanlvxqs	866	24	N	n	CD
cord-296347-fanlvxqs	866	25	-	-	HYPH
cord-296347-fanlvxqs	866	26	terminal	terminal	JJ
cord-296347-fanlvxqs	866	27	UEV	UEV	NNP
cord-296347-fanlvxqs	866	28	domain	domain	NN
cord-296347-fanlvxqs	866	29	that	that	WDT
cord-296347-fanlvxqs	866	30	binds	bind	VBZ
cord-296347-fanlvxqs	866	31	ubiquitin	ubiquitin	JJ
cord-296347-fanlvxqs	866	32	.	.	.
cord-296347-fanlvxqs	867	1	Binding	bind	VBG
cord-296347-fanlvxqs	867	2	of	of	IN
cord-296347-fanlvxqs	867	3	the	the	DT
cord-296347-fanlvxqs	867	4	TSG101	tsg101	JJ
cord-296347-fanlvxqs	867	5	UEV	UEV	NNP
cord-296347-fanlvxqs	867	6	domain	domain	NN
cord-296347-fanlvxqs	867	7	to	to	IN
cord-296347-fanlvxqs	867	8	a	a	DT
cord-296347-fanlvxqs	867	9	P(S	P(S	NNP
cord-296347-fanlvxqs	867	10	/	/	,
cord-296347-fanlvxqs	867	11	T)AP	T)AP	NNP
cord-296347-fanlvxqs	867	12	tetrapeptide	tetrapeptide	NN
cord-296347-fanlvxqs	867	13	motif	motif	NN
cord-296347-fanlvxqs	867	14	on	on	IN
cord-296347-fanlvxqs	867	15	HRS	HRS	NNP
cord-296347-fanlvxqs	867	16	recruits	recruit	VBZ
cord-296347-fanlvxqs	867	17	HRS	HRS	NNP
cord-296347-fanlvxqs	867	18	to	to	IN
cord-296347-fanlvxqs	867	19	the	the	DT
cord-296347-fanlvxqs	867	20	endosomal	endosomal	NNP
cord-296347-fanlvxqs	867	21	membrane	membrane	NN
cord-296347-fanlvxqs	867	22	,	,	,
cord-296347-fanlvxqs	867	23	triggering	trigger	VBG
cord-296347-fanlvxqs	867	24	assembly	assembly	NN
cord-296347-fanlvxqs	867	25	of	of	IN
cord-296347-fanlvxqs	867	26	ESCRT	ESCRT	NNP
cord-296347-fanlvxqs	867	27	complexes	complex	NNS
cord-296347-fanlvxqs	867	28	and	and	CC
cord-296347-fanlvxqs	867	29	genesis	genesis	NN
cord-296347-fanlvxqs	867	30	of	of	IN
cord-296347-fanlvxqs	867	31	the	the	DT
cord-296347-fanlvxqs	867	32	MVB	MVB	NNP
cord-296347-fanlvxqs	867	33	(	(	-LRB-
cord-296347-fanlvxqs	867	34	Clague	Clague	NNP
cord-296347-fanlvxqs	867	35	and	and	CC
cord-296347-fanlvxqs	867	36	Urbe	Urbe	NNP
cord-296347-fanlvxqs	867	37	,	,	,
cord-296347-fanlvxqs	867	38	2003	2003	CD
cord-296347-fanlvxqs	867	39	;	;	:
cord-296347-fanlvxqs	868	1	Garrus	Garrus	NNP
cord-296347-fanlvxqs	868	2	et	et	NNP
cord-296347-fanlvxqs	868	3	al	al	NNP
cord-296347-fanlvxqs	868	4	.	.	NNP
cord-296347-fanlvxqs	868	5	,	,	,
cord-296347-fanlvxqs	868	6	2001	2001	CD
cord-296347-fanlvxqs	869	1	;	;	:
cord-296347-fanlvxqs	869	2	Pornillos	Pornillos	NNP
cord-296347-fanlvxqs	869	3	et	et	NNP
cord-296347-fanlvxqs	869	4	al	al	NNP
cord-296347-fanlvxqs	869	5	.	.	.
cord-296347-fanlvxqs	870	1	,	,	,
cord-296347-fanlvxqs	870	2	2002	2002	CD
cord-296347-fanlvxqs	871	1	Pornillos	Pornillos	NNP
cord-296347-fanlvxqs	871	2	et	et	NNP
cord-296347-fanlvxqs	871	3	al	al	NNP
cord-296347-fanlvxqs	871	4	.	.	NNP
cord-296347-fanlvxqs	871	5	,	,	,
cord-296347-fanlvxqs	871	6	,	,	,
cord-296347-fanlvxqs	871	7	2003	2003	CD
cord-296347-fanlvxqs	871	8	.	.	.
cord-296347-fanlvxqs	872	1	Many	many	JJ
cord-296347-fanlvxqs	872	2	viruses	virus	NNS
cord-296347-fanlvxqs	872	3	such	such	JJ
cord-296347-fanlvxqs	872	4	as	as	IN
cord-296347-fanlvxqs	872	5	HIV-1	HIV-1	NNP
cord-296347-fanlvxqs	872	6	and	and	CC
cord-296347-fanlvxqs	872	7	Ebola	Ebola	NNP
cord-296347-fanlvxqs	872	8	recruit	recruit	VBP
cord-296347-fanlvxqs	872	9	this	this	DT
cord-296347-fanlvxqs	872	10	Ub	ub	JJ
cord-296347-fanlvxqs	872	11	-	-	HYPH
cord-296347-fanlvxqs	872	12	dependent	dependent	JJ
cord-296347-fanlvxqs	872	13	sorting	sort	VBG
cord-296347-fanlvxqs	872	14	machinery	machinery	NN
cord-296347-fanlvxqs	872	15	to	to	IN
cord-296347-fanlvxqs	872	16	the	the	DT
cord-296347-fanlvxqs	872	17	viral	viral	JJ
cord-296347-fanlvxqs	872	18	release	release	NN
cord-296347-fanlvxqs	872	19	sites	site	NNS
cord-296347-fanlvxqs	872	20	at	at	IN
cord-296347-fanlvxqs	872	21	the	the	DT
cord-296347-fanlvxqs	872	22	plasma	plasma	NN
cord-296347-fanlvxqs	872	23	membrane	membrane	NN
cord-296347-fanlvxqs	872	24	to	to	TO
cord-296347-fanlvxqs	872	25	promote	promote	VB
cord-296347-fanlvxqs	872	26	virus	virus	NN
cord-296347-fanlvxqs	872	27	budding	bud	VBG
cord-296347-fanlvxqs	872	28	from	from	IN
cord-296347-fanlvxqs	872	29	host	host	NN
cord-296347-fanlvxqs	872	30	cells	cell	NNS
cord-296347-fanlvxqs	872	31	(	(	-LRB-
cord-296347-fanlvxqs	872	32	Li	Li	NNP
cord-296347-fanlvxqs	872	33	and	and	CC
cord-296347-fanlvxqs	872	34	Wild	Wild	NNP
cord-296347-fanlvxqs	872	35	,	,	,
cord-296347-fanlvxqs	872	36	2005	2005	CD
cord-296347-fanlvxqs	872	37	;	;	:
cord-296347-fanlvxqs	872	38	Liu	Liu	NNP
cord-296347-fanlvxqs	872	39	,	,	,
cord-296347-fanlvxqs	872	40	2004	2004	CD
cord-296347-fanlvxqs	872	41	)	)	-RRB-
cord-296347-fanlvxqs	872	42	,	,	,
cord-296347-fanlvxqs	872	43	by	by	IN
cord-296347-fanlvxqs	872	44	makin	makin	FW
cord-296347-fanlvxqs	872	45	g	g	NNP
cord-296347-fanlvxqs	872	46	use	use	NN
cord-296347-fanlvxqs	872	47	of	of	IN
cord-296347-fanlvxqs	872	48	con	con	NN
cord-296347-fanlvxqs	872	49	served	serve	VBN
cord-296347-fanlvxqs	873	1	P(S	P(S	NNP
cord-296347-fanlvxqs	874	1	/T)AP	/T)AP	NFP
cord-296347-fanlvxqs	874	2	,	,	,
cord-296347-fanlvxqs	874	3	PPXY	PPXY	NNP
cord-296347-fanlvxqs	874	4	,	,	,
cord-296347-fanlvxqs	874	5	or	or	CC
cord-296347-fanlvxqs	874	6	FPIV	FPIV	NNP
cord-296347-fanlvxqs	874	7	motifs	motif	NNS
cord-296347-fanlvxqs	874	8	,	,	,
cord-296347-fanlvxqs	874	9	also	also	RB
cord-296347-fanlvxqs	874	10	called	call	VBN
cord-296347-fanlvxqs	874	11	late	late	JJ
cord-296347-fanlvxqs	874	12	budding	budding	NN
cord-296347-fanlvxqs	874	13	domains	domain	NNS
cord-296347-fanlvxqs	874	14	(	(	-LRB-
cord-296347-fanlvxqs	874	15	Bieniasz	Bieniasz	NNP
cord-296347-fanlvxqs	874	16	,	,	,
cord-296347-fanlvxqs	874	17	2006	2006	CD
cord-296347-fanlvxqs	874	18	)	)	-RRB-
cord-296347-fanlvxqs	874	19	.	.	.
cord-296347-fanlvxqs	875	1	Retroviruse	Retroviruse	NNP
cord-296347-fanlvxqs	875	2	s	s	NNP
cord-296347-fanlvxqs	876	1	like	like	IN
cord-296347-fanlvxqs	876	2	HIV	HIV	NNP
cord-296347-fanlvxqs	876	3	use	use	VBP
cord-296347-fanlvxqs	876	4	the	the	DT
cord-296347-fanlvxqs	876	5	P(S	P(S	NNPS
cord-296347-fanlvxqs	876	6	/	/	SYM
cord-296347-fanlvxqs	876	7	T	T	NNP
cord-296347-fanlvxqs	876	8	)	)	-RRB-
cord-296347-fanlvxqs	876	9	AP	AP	NNP
cord-296347-fanlvxqs	876	10	motif	motif	NN
cord-296347-fanlvxqs	876	11	on	on	IN
cord-296347-fanlvxqs	876	12	the	the	DT
cord-296347-fanlvxqs	876	13	Ldomain	Ldomain	NNP
cord-296347-fanlvxqs	876	14	contained	contain	VBD
cord-296347-fanlvxqs	876	15	in	in	IN
cord-296347-fanlvxqs	876	16	their	-PRON-	PRP$
cord-296347-fanlvxqs	876	17	GAG	GAG	NNP
cord-296347-fanlvxqs	876	18	protei	protei	NN
cord-296347-fanlvxqs	876	19	n	n	NN
cord-296347-fanlvxqs	876	20	to	to	TO
cord-296347-fanlvxqs	876	21	mimic	mimic	VB
cord-296347-fanlvxqs	876	22	the	the	DT
cord-296347-fanlvxqs	876	23	TSG10	TSG10	NNP
cord-296347-fanlvxqs	876	24	1-rec	1-rec	CD
cord-296347-fanlvxqs	876	25	ruiting	ruite	VBG
cord-296347-fanlvxqs	876	26	activ	activ	NNP
cord-296347-fanlvxqs	876	27	ity	ity	NN
cord-296347-fanlvxqs	876	28	of	of	IN
cord-296347-fanlvxqs	876	29	the	the	DT
cord-296347-fanlvxqs	876	30	HRS	HRS	NNP
cord-296347-fanlvxqs	876	31	protein	protein	NN
cord-296347-fanlvxqs	876	32	(	(	-LRB-
cord-296347-fanlvxqs	876	33	Klinger	Klinger	NNP
cord-296347-fanlvxqs	876	34	an	an	DT
cord-296347-fanlvxqs	876	35	d	d	NNP
cord-296347-fanlvxqs	876	36	Schube	Schube	NNP
cord-296347-fanlvxqs	876	37	rt	rt	NNP
cord-296347-fanlvxqs	876	38	,	,	,
cord-296347-fanlvxqs	876	39	2005	2005	CD
cord-296347-fanlvxqs	876	40	;	;	:
cord-296347-fanlvxqs	877	1	Martin	Martin	NNP
cord-296347-fanlvxqs	877	2	-Serra	-Serra	:
cord-296347-fanlvxqs	877	3	no	no	DT
cord-296347-fanlvxqs	878	1	et	et	NNP
cord-296347-fanlvxqs	878	2	al	al	NNP
cord-296347-fanlvxqs	878	3	.	.	.
cord-296347-fanlvxqs	879	1	,	,	,
cord-296347-fanlvxqs	879	2	2003	2003	CD
cord-296347-fanlvxqs	879	3	;	;	:
cord-296347-fanlvxqs	879	4	Sor	Sor	NNP
cord-296347-fanlvxqs	879	5	in	in	IN
cord-296347-fanlvxqs	879	6	and	and	CC
cord-296347-fanlvxqs	879	7	Kalpana	Kalpana	NNP
cord-296347-fanlvxqs	879	8	,	,	,
cord-296347-fanlvxqs	879	9	2006	2006	CD
cord-296347-fanlvxqs	879	10	;	;	:
cord-296347-fanlvxqs	879	11	Stuchell	Stuchell	NNP
cord-296347-fanlvxqs	879	12	et	et	NNP
cord-296347-fanlvxqs	879	13	al	al	NNP
cord-296347-fanlvxqs	879	14	.	.	NNP
cord-296347-fanlvxqs	879	15	,	,	,
cord-296347-fanlvxqs	879	16	2004	2004	CD
cord-296347-fanlvxqs	879	17	)	)	-RRB-
cord-296347-fanlvxqs	879	18	.	.	.
cord-296347-fanlvxqs	880	1	Oth	Oth	NNS
cord-296347-fanlvxqs	880	2	er	er	UH
cord-296347-fanlvxqs	880	3	viruses	virus	NNS
cord-296347-fanlvxqs	880	4	can	can	MD
cord-296347-fanlvxqs	880	5	also	also	RB
cord-296347-fanlvxqs	880	6	rec	rec	NNP
cord-296347-fanlvxqs	880	7	ruit	ruit	NNP
cord-296347-fanlvxqs	880	8	neuro	neuro	NNP
cord-296347-fanlvxqs	880	9	nal	nal	NNP
cord-296347-fanlvxqs	880	10	precurs	precurs	NNP
cord-296347-fanlvxqs	880	11	or	or	CC
cord-296347-fanlvxqs	880	12	cellexpresse	cellexpresse	NNP
cord-296347-fanlvxqs	880	13	d	d	NNP
cord-296347-fanlvxqs	881	1	develop	develop	VB
cord-296347-fanlvxqs	881	2	mentally	mentally	RB
cord-296347-fanlvxqs	881	3	dow	dow	NNP
cord-296347-fanlvxqs	881	4	nregula	nregula	NNP
cord-296347-fanlvxqs	881	5	t	t	NNP
cord-296347-fanlvxqs	881	6	ed	ed	NNP
cord-296347-fanlvxqs	881	7	4	4	CD
cord-296347-fanlvxqs	882	1	(	(	-LRB-
cord-296347-fanlvxqs	882	2	NEDD	NEDD	NNP
cord-296347-fanlvxqs	882	3	4	4	CD
cord-296347-fanlvxqs	882	4	)	)	-RRB-
cord-296347-fanlvxqs	882	5	and	and	CC
cord-296347-fanlvxqs	882	6	NEDD	NEDD	NNP
cord-296347-fanlvxqs	882	7	-4-like	-4-like	CD
cord-296347-fanlvxqs	882	8	HECT	HECT	NNP
cord-296347-fanlvxqs	882	9	E3	E3	NNP
cord-296347-fanlvxqs	882	10	ligases	ligase	NNS
cord-296347-fanlvxqs	882	11	to	to	TO
cord-296347-fanlvxqs	882	12	facilitate	facilitate	VB
cord-296347-fanlvxqs	882	13	viral	viral	JJ
cord-296347-fanlvxqs	882	14	bud	bud	NN
cord-296347-fanlvxqs	882	15	ding	ding	NN
cord-296347-fanlvxqs	882	16	(	(	-LRB-
cord-296347-fanlvxqs	882	17	Bieniasz	Bieniasz	NNP
cord-296347-fanlvxqs	882	18	,	,	,
cord-296347-fanlvxqs	882	19	2006	2006	CD
cord-296347-fanlvxqs	882	20	;	;	:
cord-296347-fanlvxqs	882	21	Harty	Harty	NNP
cord-296347-fanlvxqs	882	22	et	et	NNP
cord-296347-fanlvxqs	882	23	al	al	NNP
cord-296347-fanlvxqs	882	24	.	.	NNP
cord-296347-fanlvxqs	882	25	,	,	,
cord-296347-fanlvxqs	882	26	20	20	CD
cord-296347-fanlvxqs	882	27	01	01	CD
cord-296347-fanlvxqs	882	28	;	;	.
cord-296347-fanlvxqs	883	1	Sakura	Sakura	NNP
cord-296347-fanlvxqs	883	2	i	i	PRP
cord-296347-fanlvxqs	883	3	et	et	NNP
cord-296347-fanlvxqs	883	4	al	al	NNP
cord-296347-fanlvxqs	883	5	.	.	NNP
cord-296347-fanlvxqs	883	6	,	,	,
cord-296347-fanlvxqs	883	7	20	20	CD
cord-296347-fanlvxqs	883	8	04	04	CD
cord-296347-fanlvxqs	884	1	;	;	:
cord-296347-fanlvxqs	884	2	Yasuda	Yasuda	NNP
cord-296347-fanlvxqs	884	3	et	et	NNP
cord-296347-fanlvxqs	884	4	al	al	NNP
cord-296347-fanlvxqs	884	5	.	.	NNP
cord-296347-fanlvxqs	884	6	,	,	,
cord-296347-fanlvxqs	884	7	2003	2003	CD
cord-296347-fanlvxqs	884	8	)	)	-RRB-
cord-296347-fanlvxqs	884	9	.	.	.
cord-296347-fanlvxqs	885	1	NE	NE	NNP
cord-296347-fanlvxqs	885	2	DD4	DD4	NNP
cord-296347-fanlvxqs	885	3	E3s	e3s	FW
cord-296347-fanlvxqs	885	4	ligase	ligase	NN
cord-296347-fanlvxqs	885	5	s	s	NNS
cord-296347-fanlvxqs	885	6	are	be	VBP
cord-296347-fanlvxqs	885	7	a	a	DT
cord-296347-fanlvxqs	885	8	dive	dive	NN
cord-296347-fanlvxqs	885	9	rsified	rsifie	VBN
cord-296347-fanlvxqs	885	10	group	group	NN
cord-296347-fanlvxqs	885	11	of	of	IN
cord-296347-fanlvxqs	885	12	orthologu	orthologu	NNP
cord-296347-fanlvxqs	885	13	es	es	NNP
cord-296347-fanlvxqs	885	14	of	of	IN
cord-296347-fanlvxqs	885	15	yeast	yeast	NN
cord-296347-fanlvxqs	885	16	Rsp5p	rsp5p	NN
cord-296347-fanlvxqs	885	17	and	and	CC
cord-296347-fanlvxqs	885	18	are	be	VBP
cord-296347-fanlvxqs	885	19	in	in	IN
cord-296347-fanlvxqs	885	20	volved	volved	NN
cord-296347-fanlvxqs	885	21	in	in	IN
cord-296347-fanlvxqs	885	22	a	a	DT
cord-296347-fanlvxqs	885	23	wid	wid	NN
cord-296347-fanlvxqs	885	24	e	e	NN
cord-296347-fanlvxqs	885	25	range	range	NN
cord-296347-fanlvxqs	885	26	of	of	IN
cord-296347-fanlvxqs	885	27	proce	proce	NNP
cord-296347-fanlvxqs	885	28	sses	sse	NNS
cord-296347-fanlvxqs	885	29	such	such	JJ
cord-296347-fanlvxqs	885	30	as	as	IN
cord-296347-fanlvxqs	885	31	recepto	recepto	NNP
cord-296347-fanlvxqs	885	32	r	r	NNP
cord-296347-fanlvxqs	885	33	inter	inter	NNP
cord-296347-fanlvxqs	885	34	nalizati	nalizati	RB
cord-296347-fanlvxqs	885	35	on	on	IN
cord-296347-fanlvxqs	885	36	and	and	CC
cord-296347-fanlvxqs	885	37	degrad	degrad	NN
cord-296347-fanlvxqs	885	38	ation	ation	NN
cord-296347-fanlvxqs	886	1	(	(	-LRB-
cord-296347-fanlvxqs	886	2	presum	presum	NNP
cord-296347-fanlvxqs	886	3	ably	ably	RB
cord-296347-fanlvxqs	886	4	through	through	IN
cord-296347-fanlvxqs	886	5	the	the	DT
cord-296347-fanlvxqs	886	6	endoly	endoly	NNP
cord-296347-fanlvxqs	886	7	sosomal	sosomal	NNP
cord-296347-fanlvxqs	886	8	pa	pa	NNP
cord-296347-fanlvxqs	886	9	thway	thway	NNP
cord-296347-fanlvxqs	886	10	)	)	-RRB-
cord-296347-fanlvxqs	886	11	,	,	,
cord-296347-fanlvxqs	886	12	mainten	mainten	NNP
cord-296347-fanlvxqs	886	13	ance	ance	NN
cord-296347-fanlvxqs	886	14	of	of	IN
cord-296347-fanlvxqs	886	15	EBV	EBV	NNP
cord-296347-fanlvxqs	886	16	latency	latency	NN
cord-296347-fanlvxqs	886	17	,	,	,
cord-296347-fanlvxqs	886	18	and	and	CC
cord-296347-fanlvxqs	886	19	regulation	regulation	NN
cord-296347-fanlvxqs	886	20	of	of	IN
cord-296347-fanlvxqs	886	21	cytokine	cytokine	NN
cord-296347-fanlvxqs	886	22	sig	sig	NN
cord-296347-fanlvxqs	886	23	naling	naling	NN
cord-296347-fanlvxqs	886	24	.	.	.
cord-296347-fanlvxqs	887	1	NED	NED	NNP
cord-296347-fanlvxqs	887	2	D4	D4	NNP
cord-296347-fanlvxqs	887	3	E3s	e3s	NN
cord-296347-fanlvxqs	887	4	have	have	VBP
cord-296347-fanlvxqs	887	5	a	a	DT
cord-296347-fanlvxqs	887	6	catal	catal	NNP
cord-296347-fanlvxqs	887	7	ytic	ytic	JJ
cord-296347-fanlvxqs	887	8	Cterminal	Cterminal	NNP
cord-296347-fanlvxqs	887	9	HEC	HEC	NNP
cord-296347-fanlvxqs	887	10	T	T	NNP
cord-296347-fanlvxqs	887	11	domain	domain	NN
cord-296347-fanlvxqs	887	12	,	,	,
cord-296347-fanlvxqs	887	13	two	two	CD
cord-296347-fanlvxqs	887	14	or	or	CC
cord-296347-fanlvxqs	887	15	more	more	JJR
cord-296347-fanlvxqs	887	16	centr	centr	NN
cord-296347-fanlvxqs	887	17	al	al	NNP
cord-296347-fanlvxqs	887	18	Nterminal	Nterminal	NNP
cord-296347-fanlvxqs	887	19	WW	WW	NNP
cord-296347-fanlvxqs	887	20	dom	dom	NNP
cord-296347-fanlvxqs	887	21	ains	ains	NNP
cord-296347-fanlvxqs	887	22	,	,	,
cord-296347-fanlvxqs	887	23	an	an	DT
cord-296347-fanlvxqs	887	24	d	d	XX
cord-296347-fanlvxqs	887	25	an	an	DT
cord-296347-fanlvxqs	887	26	N	n	CD
cord-296347-fanlvxqs	887	27	-	-	HYPH
cord-296347-fanlvxqs	887	28	term	term	NN
cord-296347-fanlvxqs	887	29	inal	inal	JJ
cord-296347-fanlvxqs	887	30	C2	C2	NNP
cord-296347-fanlvxqs	887	31	dom	dom	NNP
cord-296347-fanlvxqs	887	32	ain	ain	NNP
cord-296347-fanlvxqs	887	33	.	.	.
cord-296347-fanlvxqs	888	1	The	the	DT
cord-296347-fanlvxqs	888	2	Nterminal	Nterminal	NNP
cord-296347-fanlvxqs	888	3	C2	C2	NNP
cord-296347-fanlvxqs	888	4	domain	domain	NN
cord-296347-fanlvxqs	888	5	seems	seem	VBZ
cord-296347-fanlvxqs	888	6	to	to	TO
cord-296347-fanlvxqs	888	7	be	be	VB
cord-296347-fanlvxqs	888	8	responsi	responsi	NNP
cord-296347-fanlvxqs	888	9	ble	ble	JJ
cord-296347-fanlvxqs	888	10	for	for	IN
cord-296347-fanlvxqs	888	11	me	-PRON-	PRP
cord-296347-fanlvxqs	888	12	mbrane	mbrane	NNP
cord-296347-fanlvxqs	888	13	associ	associ	NNP
cord-296347-fanlvxqs	888	14	ation	ation	NNP
cord-296347-fanlvxqs	888	15	and	and	CC
cord-296347-fanlvxqs	888	16	cellu	cellu	NNP
cord-296347-fanlvxqs	889	1	lar	lar	NNP
cord-296347-fanlvxqs	889	2	localizatio	localizatio	NNP
cord-296347-fanlvxqs	889	3	n	n	NNP
cord-296347-fanlvxqs	889	4	of	of	IN
cord-296347-fanlvxqs	889	5	the	the	DT
cord-296347-fanlvxqs	889	6	pro	pro	NNP
cord-296347-fanlvxqs	889	7	tein	tein	NNP
cord-296347-fanlvxqs	889	8	.	.	.
cord-296347-fanlvxqs	890	1	The	the	DT
cord-296347-fanlvxqs	890	2	WW	WW	NNP
cord-296347-fanlvxqs	890	3	dom	dom	NNP
cord-296347-fanlvxqs	890	4	ain	ain	NNP
cord-296347-fanlvxqs	890	5	is	be	VBZ
cord-296347-fanlvxqs	890	6	a	a	DT
cord-296347-fanlvxqs	890	7	protei	protei	NN
cord-296347-fanlvxqs	890	8	n	n	NNP
cord-296347-fanlvxqs	890	9	-	-	HYPH
cord-296347-fanlvxqs	890	10	protei	protei	NNP
cord-296347-fanlvxqs	890	11	n	n	NNP
cord-296347-fanlvxqs	890	12	interactio	interactio	NNP
cord-296347-fanlvxqs	890	13	n	n	NNP
cord-296347-fanlvxqs	890	14	modul	modul	NNP
cord-296347-fanlvxqs	890	15	e	e	NNP
cord-296347-fanlvxqs	891	1	o	o	UH
cord-296347-fanlvxqs	891	2	f	f	NNP
cord-296347-fanlvxqs	891	3	abou	abou	NNP
cord-296347-fanlvxqs	891	4	t	t	NNP
cord-296347-fanlvxqs	891	5	35	35	CD
cord-296347-fanlvxqs	891	6	amino	amino	JJ
cord-296347-fanlvxqs	891	7	acids	acid	NNS
cord-296347-fanlvxqs	891	8	with	with	IN
cord-296347-fanlvxqs	891	9	two	two	CD
cord-296347-fanlvxqs	891	10	crucia	crucia	NNP
cord-296347-fanlvxqs	891	11	l	l	NNP
cord-296347-fanlvxqs	891	12	tryptop	tryptop	NNP
cord-296347-fanlvxqs	891	13	han	han	NNP
cord-296347-fanlvxqs	891	14	(	(	-LRB-
cord-296347-fanlvxqs	891	15	W	W	NNP
cord-296347-fanlvxqs	891	16	)	)	-RRB-
cord-296347-fanlvxqs	891	17	residues	residue	NNS
cord-296347-fanlvxqs	891	18	spa	spa	NN
cord-296347-fanlvxqs	891	19	ced	ced	NNP
cord-296347-fanlvxqs	891	20	20	20	CD
cord-296347-fanlvxqs	891	21	-	-	SYM
cord-296347-fanlvxqs	891	22	22	22	CD
cord-296347-fanlvxqs	892	1	amin	amin	NNP
cord-296347-fanlvxqs	892	2	o	o	CD
cord-296347-fanlvxqs	892	3	acids	acid	NNS
cord-296347-fanlvxqs	892	4	apart	apart	RB
cord-296347-fanlvxqs	892	5	,	,	,
cord-296347-fanlvxqs	892	6	which	which	WDT
cord-296347-fanlvxqs	892	7	appear	appear	VBP
cord-296347-fanlvxqs	892	8	s	s	NNS
cord-296347-fanlvxqs	892	9	to	to	TO
cord-296347-fanlvxqs	892	10	medi	medi	NNP
cord-296347-fanlvxqs	892	11	ate	eat	VBD
cord-296347-fanlvxqs	892	12	substr	substr	NN
cord-296347-fanlvxqs	892	13	ate	eat	VBD
cord-296347-fanlvxqs	892	14	selection	selection	NN
cord-296347-fanlvxqs	892	15	.	.	.
cord-296347-fanlvxqs	893	1	It	-PRON-	PRP
cord-296347-fanlvxqs	893	2	binds	bind	VBZ
cord-296347-fanlvxqs	893	3	mostly	mostly	RB
cord-296347-fanlvxqs	893	4	pro	pro	JJ
cord-296347-fanlvxqs	893	5	linerich	linerich	JJ
cord-296347-fanlvxqs	893	6	motifs	motif	NNS
cord-296347-fanlvxqs	893	7	,	,	,
cord-296347-fanlvxqs	893	8	such	such	JJ
cord-296347-fanlvxqs	893	9	as	as	IN
cord-296347-fanlvxqs	893	10	the	the	DT
cord-296347-fanlvxqs	893	11	PPXY	PPXY	NNP
cord-296347-fanlvxqs	893	12	motif	motif	NN
cord-296347-fanlvxqs	893	13	present	present	JJ
cord-296347-fanlvxqs	893	14	in	in	IN
cord-296347-fanlvxqs	893	15	many	many	JJ
cord-296347-fanlvxqs	893	16	cellular	cellular	JJ
cord-296347-fanlvxqs	893	17	proteins	protein	NNS
cord-296347-fanlvxqs	893	18	,	,	,
cord-296347-fanlvxqs	893	19	targeting	target	VBG
cord-296347-fanlvxqs	893	20	them	-PRON-	PRP
cord-296347-fanlvxqs	893	21	for	for	IN
cord-296347-fanlvxqs	893	22	degradati	degradati	JJS
cord-296347-fanlvxqs	893	23	on	on	IN
cord-296347-fanlvxqs	893	24	(	(	-LRB-
cord-296347-fanlvxqs	893	25	Ingham	Ingham	NNP
cord-296347-fanlvxqs	893	26	et	et	NNP
cord-296347-fanlvxqs	893	27	al	al	NNP
cord-296347-fanlvxqs	893	28	.	.	NNP
cord-296347-fanlvxqs	893	29	,	,	,
cord-296347-fanlvxqs	893	30	2004	2004	CD
cord-296347-fanlvxqs	894	1	(	(	-LRB-
cord-296347-fanlvxqs	894	2	Ingham	Ingham	NNP
cord-296347-fanlvxqs	894	3	et	et	NNP
cord-296347-fanlvxqs	894	4	al	al	NNP
cord-296347-fanlvxqs	894	5	.	.	NNP
cord-296347-fanlvxqs	894	6	,	,	,
cord-296347-fanlvxqs	894	7	,	,	,
cord-296347-fanlvxqs	894	8	2005	2005	CD
cord-296347-fanlvxqs	894	9	.	.	.
cord-296347-fanlvxqs	895	1	Viral	viral	JJ
cord-296347-fanlvxqs	895	2	pro	pro	FW
cord-296347-fanlvxqs	895	3	teins	tein	NNS
cord-296347-fanlvxqs	895	4	with	with	IN
cord-296347-fanlvxqs	896	1	the	the	DT
cord-296347-fanlvxqs	896	2	PPXY	PPXY	NNP
cord-296347-fanlvxqs	896	3	mo	mo	NNP
cord-296347-fanlvxqs	896	4	tif	tif	NN
cord-296347-fanlvxqs	896	5	can	can	MD
cord-296347-fanlvxqs	896	6	therefore	therefore	RB
cord-296347-fanlvxqs	896	7	bind	bind	VB
cord-296347-fanlvxqs	896	8	these	these	DT
cord-296347-fanlvxqs	896	9	WW	WW	NNP
cord-296347-fanlvxqs	896	10	dom	dom	NNP
cord-296347-fanlvxqs	896	11	ains	ains	NNP
cord-296347-fanlvxqs	896	12	on	on	IN
cord-296347-fanlvxqs	896	13	Nedd	Nedd	NNP
cord-296347-fanlvxqs	896	14	4	4	CD
cord-296347-fanlvxqs	896	15	E3s	e3s	NN
cord-296347-fanlvxqs	896	16	,	,	,
cord-296347-fanlvxqs	896	17	but	but	CC
cord-296347-fanlvxqs	896	18	the	the	DT
cord-296347-fanlvxqs	896	19	na	na	NNP
cord-296347-fanlvxqs	896	20	ture	ture	NN
cord-296347-fanlvxqs	896	21	of	of	IN
cord-296347-fanlvxqs	896	22	these	these	DT
cord-296347-fanlvxqs	896	23	inter	inter	JJ
cord-296347-fanlvxqs	896	24	actions	action	NNS
cord-296347-fanlvxqs	896	25	and	and	CC
cord-296347-fanlvxqs	896	26	how	how	WRB
cord-296347-fanlvxqs	896	27	they	-PRON-	PRP
cord-296347-fanlvxqs	896	28	facilitate	facilitate	VBP
cord-296347-fanlvxqs	896	29	virus	virus	NN
cord-296347-fanlvxqs	896	30	budd	budd	NNP
cord-296347-fanlvxqs	896	31	ing	ing	NNP
cord-296347-fanlvxqs	896	32	is	be	VBZ
cord-296347-fanlvxqs	896	33	so	so	RB
cord-296347-fanlvxqs	896	34	far	far	RB
cord-296347-fanlvxqs	896	35	unknown	unknown	JJ
cord-296347-fanlvxqs	896	36	.	.	.
cord-296347-fanlvxqs	897	1	Some	some	DT
cord-296347-fanlvxqs	897	2	viruse	viruse	NNP
cord-296347-fanlvxqs	897	3	s	s	NNP
cord-296347-fanlvxqs	897	4	,	,	,
cord-296347-fanlvxqs	897	5	like	like	IN
cord-296347-fanlvxqs	897	6	Ebola	Ebola	NNP
cord-296347-fanlvxqs	897	7	,	,	,
cord-296347-fanlvxqs	897	8	have	have	VBP
cord-296347-fanlvxqs	897	9	two	two	CD
cord-296347-fanlvxqs	897	10	different	different	JJ
cord-296347-fanlvxqs	897	11	late	late	JJ
cord-296347-fanlvxqs	897	12	buddin	buddin	NNS
cord-296347-fanlvxqs	897	13	g	g	NN
cord-296347-fanlvxqs	897	14	motifs	motif	NNS
cord-296347-fanlvxqs	897	15	,	,	,
cord-296347-fanlvxqs	897	16	PPXY	PPXY	NNP
cord-296347-fanlvxqs	897	17	and	and	CC
cord-296347-fanlvxqs	897	18	P(S	P(S	NNP
cord-296347-fanlvxqs	897	19	/	/	SYM
cord-296347-fanlvxqs	897	20	T	T	NNP
cord-296347-fanlvxqs	897	21	)	)	-RRB-
cord-296347-fanlvxqs	897	22	AP	AP	NNP
cord-296347-fanlvxqs	897	23	,	,	,
cord-296347-fanlvxqs	897	24	and	and	CC
cord-296347-fanlvxqs	897	25	the	the	DT
cord-296347-fanlvxqs	897	26	Ebola	Ebola	NNP
cord-296347-fanlvxqs	897	27	late	late	JJ
cord-296347-fanlvxqs	897	28	domain	domain	NN
cord-296347-fanlvxqs	897	29	-con	-con	.
cord-296347-fanlvxqs	898	1	taining	taine	VBG
cord-296347-fanlvxqs	898	2	VP40	VP40	NNP
cord-296347-fanlvxqs	898	3	matrix	matrix	NN
cord-296347-fanlvxqs	898	4	protein	protein	NN
cord-296347-fanlvxqs	898	5	can	can	MD
cord-296347-fanlvxqs	898	6	recruit	recruit	VB
cord-296347-fanlvxqs	898	7	bot	bot	NN
cord-296347-fanlvxqs	898	8	h	h	NN
cord-296347-fanlvxqs	898	9	TSG	TSG	NNP
cord-296347-fanlvxqs	898	10	101	101	CD
cord-296347-fanlvxqs	898	11	and	and	CC
cord-296347-fanlvxqs	898	12	NEDD4	NEDD4	NNP
cord-296347-fanlvxqs	898	13	for	for	IN
cord-296347-fanlvxqs	898	14	effec	effec	JJ
cord-296347-fanlvxqs	898	15	tive	tive	NNP
cord-296347-fanlvxqs	898	16	budding	budding	NN
cord-296347-fanlvxqs	899	1	(	(	-LRB-
cord-296347-fanlvxqs	899	2	Lic	Lic	NNP
cord-296347-fanlvxqs	899	3	ata	ata	NNP
cord-296347-fanlvxqs	899	4	et	et	NNP
cord-296347-fanlvxqs	899	5	al	al	NNP
cord-296347-fanlvxqs	899	6	.	.	NNP
cord-296347-fanlvxqs	899	7	,	,	,
cord-296347-fanlvxqs	899	8	2003	2003	CD
cord-296347-fanlvxqs	899	9	;	;	:
cord-296347-fanlvxqs	899	10	Liu	Liu	NNP
cord-296347-fanlvxqs	899	11	,	,	,
cord-296347-fanlvxqs	899	12	2004	2004	CD
cord-296347-fanlvxqs	899	13	;	;	:
cord-296347-fanlvxqs	899	14	Yasuda	Yasuda	NNP
cord-296347-fanlvxqs	899	15	et	et	NNP
cord-296347-fanlvxqs	899	16	al	al	NNP
cord-296347-fanlvxqs	899	17	.	.	NNP
cord-296347-fanlvxqs	899	18	,	,	,
cord-296347-fanlvxqs	899	19	2003	2003	CD
cord-296347-fanlvxqs	899	20	)	)	-RRB-
cord-296347-fanlvxqs	899	21	.	.	.
cord-296347-fanlvxqs	900	1	The	the	DT
cord-296347-fanlvxqs	900	2	nonen	nonen	NNP
cord-296347-fanlvxqs	900	3	veloped	veloped	NNP
cord-296347-fanlvxqs	900	4	adenov	adenov	NNP
cord-296347-fanlvxqs	900	5	irus	irus	NNP
cord-296347-fanlvxqs	900	6	pos	pos	NNP
cord-296347-fanlvxqs	900	7	sesses	sesse	VBZ
cord-296347-fanlvxqs	900	8	a	a	DT
cord-296347-fanlvxqs	900	9	PPXY	PPXY	NNP
cord-296347-fanlvxqs	900	10	motif	motif	NN
cord-296347-fanlvxqs	900	11	on	on	IN
cord-296347-fanlvxqs	900	12	its	-PRON-	PRP$
cord-296347-fanlvxqs	900	13	penton	penton	NNP
cord-296347-fanlvxqs	900	14	base	base	NNP
cord-296347-fanlvxqs	900	15	protein	protein	NNP
cord-296347-fanlvxqs	900	16	,	,	,
cord-296347-fanlvxqs	900	17	which	which	WDT
cord-296347-fanlvxqs	900	18	is	be	VBZ
cord-296347-fanlvxqs	900	19	essential	essential	JJ
cord-296347-fanlvxqs	900	20	for	for	IN
cord-296347-fanlvxqs	900	21	virus	virus	NN
cord-296347-fanlvxqs	900	22	internalization	internalization	NN
cord-296347-fanlvxqs	900	23	that	that	WDT
cord-296347-fanlvxqs	900	24	can	can	MD
cord-296347-fanlvxqs	900	25	interact	interact	VB
cord-296347-fanlvxqs	900	26	with	with	IN
cord-296347-fanlvxqs	900	27	several	several	JJ
cord-296347-fanlvxqs	900	28	NEDD4	nedd4	JJ
cord-296347-fanlvxqs	900	29	HECT	HECT	NNS
cord-296347-fanlvxqs	900	30	E3	e3	NN
cord-296347-fanlvxqs	900	31	ligases	ligase	NNS
cord-296347-fanlvxqs	900	32	(	(	-LRB-
cord-296347-fanlvxqs	900	33	Galinier	Galinier	NNP
cord-296347-fanlvxqs	900	34	et	et	NNP
cord-296347-fanlvxqs	900	35	al	al	NNP
cord-296347-fanlvxqs	900	36	.	.	NNP
cord-296347-fanlvxqs	900	37	,	,	,
cord-296347-fanlvxqs	900	38	2002	2002	CD
cord-296347-fanlvxqs	900	39	)	)	-RRB-
cord-296347-fanlvxqs	900	40	.	.	.
cord-296347-fanlvxqs	901	1	Whether	whether	IN
cord-296347-fanlvxqs	901	2	or	or	CC
cord-296347-fanlvxqs	901	3	not	not	RB
cord-296347-fanlvxqs	901	4	this	this	DT
cord-296347-fanlvxqs	901	5	interaction	interaction	NN
cord-296347-fanlvxqs	901	6	or	or	CC
cord-296347-fanlvxqs	901	7	E3	e3	NN
cord-296347-fanlvxqs	901	8	ligase	ligase	NN
cord-296347-fanlvxqs	901	9	activity	activity	NN
cord-296347-fanlvxqs	901	10	is	be	VBZ
cord-296347-fanlvxqs	901	11	required	require	VBN
cord-296347-fanlvxqs	901	12	for	for	IN
cord-296347-fanlvxqs	901	13	adenovirus	adenovirus	NN
cord-296347-fanlvxqs	901	14	entry	entry	NN
cord-296347-fanlvxqs	901	15	is	be	VBZ
cord-296347-fanlvxqs	901	16	currently	currently	RB
cord-296347-fanlvxqs	901	17	unknown	unknown	JJ
cord-296347-fanlvxqs	901	18	.	.	.
cord-296347-fanlvxqs	902	1	Agrobacterium	Agrobacterium	NNP
cord-296347-fanlvxqs	902	2	tumefaciens	tumefaciens	NNP
cord-296347-fanlvxqs	902	3	exploits	exploit	VBZ
cord-296347-fanlvxqs	902	4	a	a	DT
cord-296347-fanlvxqs	902	5	host	host	NN
cord-296347-fanlvxqs	902	6	cell	cell	NN
cord-296347-fanlvxqs	902	7	SCF	SCF	NNP
cord-296347-fanlvxqs	902	8	E3	e3	NN
cord-296347-fanlvxqs	902	9	ligase	ligase	NN
cord-296347-fanlvxqs	902	10	for	for	IN
cord-296347-fanlvxqs	902	11	integration	integration	NN
cord-296347-fanlvxqs	902	12	of	of	IN
cord-296347-fanlvxqs	902	13	its	-PRON-	PRP$
cord-296347-fanlvxqs	902	14	T	T	NNP
cord-296347-fanlvxqs	902	15	-	-	HYPH
cord-296347-fanlvxqs	902	16	DNA	dna	NN
cord-296347-fanlvxqs	902	17	by	by	IN
cord-296347-fanlvxqs	902	18	encoding	encode	VBG
cord-296347-fanlvxqs	902	19	an	an	DT
cord-296347-fanlvxqs	902	20	Fbox	Fbox	NNP
cord-296347-fanlvxqs	902	21	pro	pro	JJ
cord-296347-fanlvxqs	902	22	tein	tein	NN
cord-296347-fanlvxqs	902	23	(	(	-LRB-
cord-296347-fanlvxqs	902	24	Tzfira	Tzfira	NNP
cord-296347-fanlvxqs	902	25	et	et	NNP
cord-296347-fanlvxqs	902	26	al	al	NNP
cord-296347-fanlvxqs	902	27	.	.	NNP
cord-296347-fanlvxqs	902	28	,	,	,
cord-296347-fanlvxqs	902	29	2004b	2004b	CD
cord-296347-fanlvxqs	902	30	)	)	-RRB-
cord-296347-fanlvxqs	902	31	.	.	.
cord-296347-fanlvxqs	903	1	Agrob	Agrob	NNP
cord-296347-fanlvxqs	903	2	acterium	acterium	NN
cord-296347-fanlvxqs	903	3	is	be	VBZ
cord-296347-fanlvxqs	903	4	a	a	DT
cord-296347-fanlvxqs	903	5	common	common	JJ
cord-296347-fanlvxqs	903	6	phytopathogenic	phytopathogenic	JJ
cord-296347-fanlvxqs	903	7	bacterium	bacterium	NN
cord-296347-fanlvxqs	903	8	that	that	WDT
cord-296347-fanlvxqs	903	9	induces	induce	VBZ
cord-296347-fanlvxqs	903	10	'	'	''
cord-296347-fanlvxqs	903	11	'	'	``
cord-296347-fanlvxqs	903	12	crown	crown	NNP
cord-296347-fanlvxqs	903	13	gall	gall	NNP
cord-296347-fanlvxqs	903	14	'	'	''
cord-296347-fanlvxqs	903	15	'	'	''
cord-296347-fanlvxqs	903	16	disease	disease	NN
cord-296347-fanlvxqs	903	17	in	in	IN
cord-296347-fanlvxqs	903	18	plants	plant	NNS
cord-296347-fanlvxqs	903	19	by	by	IN
cord-296347-fanlvxqs	903	20	transfer	transfer	NN
cord-296347-fanlvxqs	903	21	and	and	CC
cord-296347-fanlvxqs	903	22	integration	integration	NN
cord-296347-fanlvxqs	903	23	of	of	IN
cord-296347-fanlvxqs	903	24	a	a	DT
cord-296347-fanlvxqs	903	25	segment	segment	NN
cord-296347-fanlvxqs	903	26	of	of	IN
cord-296347-fanlvxqs	903	27	its	-PRON-	PRP$
cord-296347-fanlvxqs	903	28	tumor	tumor	NN
cord-296347-fanlvxqs	903	29	-	-	HYPH
cord-296347-fanlvxqs	903	30	inducing	induce	VBG
cord-296347-fanlvxqs	903	31	(	(	-LRB-
cord-296347-fanlvxqs	903	32	Ti	Ti	NNP
cord-296347-fanlvxqs	903	33	)	)	-RRB-
cord-296347-fanlvxqs	903	34	plasmid	plasmid	NN
cord-296347-fanlvxqs	903	35	DNA	dna	NN
cord-296347-fanlvxqs	903	36	into	into	IN
cord-296347-fanlvxqs	903	37	the	the	DT
cord-296347-fanlvxqs	903	38	plant	plant	NN
cord-296347-fanlvxqs	903	39	genome	genome	NN
cord-296347-fanlvxqs	903	40	.	.	.
cord-296347-fanlvxqs	904	1	This	this	DT
cord-296347-fanlvxqs	904	2	process	process	NN
cord-296347-fanlvxqs	904	3	relies	rely	VBZ
cord-296347-fanlvxqs	904	4	also	also	RB
cord-296347-fanlvxqs	904	5	on	on	IN
cord-296347-fanlvxqs	904	6	delivery	delivery	NN
cord-296347-fanlvxqs	904	7	of	of	IN
cord-296347-fanlvxqs	904	8	several	several	JJ
cord-296347-fanlvxqs	904	9	virulence	virulence	NN
cord-296347-fanlvxqs	904	10	(	(	-LRB-
cord-296347-fanlvxqs	904	11	Vir	Vir	NNP
cord-296347-fanlvxqs	904	12	)	)	-RRB-
cord-296347-fanlvxqs	904	13	proteins	protein	NNS
cord-296347-fanlvxqs	904	14	into	into	IN
cord-296347-fanlvxqs	904	15	the	the	DT
cord-296347-fanlvxqs	904	16	host	host	NN
cord-296347-fanlvxqs	904	17	cell	cell	NN
cord-296347-fanlvxqs	904	18	,	,	,
cord-296347-fanlvxqs	904	19	such	such	JJ
cord-296347-fanlvxqs	904	20	as	as	IN
cord-296347-fanlvxqs	904	21	the	the	DT
cord-296347-fanlvxqs	904	22	bacterial	bacterial	JJ
cord-296347-fanlvxqs	904	23	VirE2	VirE2	NNP
cord-296347-fanlvxqs	904	24	protein	protein	NN
cord-296347-fanlvxqs	904	25	,	,	,
cord-296347-fanlvxqs	904	26	which	which	WDT
cord-296347-fanlvxqs	904	27	is	be	VBZ
cord-296347-fanlvxqs	904	28	thought	think	VBN
cord-296347-fanlvxqs	904	29	to	to	TO
cord-296347-fanlvxqs	904	30	package	package	VB
cord-296347-fanlvxqs	904	31	and	and	CC
cord-296347-fanlvxqs	904	32	protect	protect	VB
cord-296347-fanlvxqs	904	33	the	the	DT
cord-296347-fanlvxqs	904	34	transported	transport	VBN
cord-296347-fanlvxqs	904	35	T	T	NNP
cord-296347-fanlvxqs	904	36	-	-	HYPH
cord-296347-fanlvxqs	904	37	DNA	dna	NN
cord-296347-fanlvxqs	904	38	molecule	molecule	NN
cord-296347-fanlvxqs	904	39	,	,	,
cord-296347-fanlvxqs	904	40	and	and	CC
cord-296347-fanlvxqs	904	41	,	,	,
cord-296347-fanlvxqs	904	42	together	together	RB
cord-296347-fanlvxqs	904	43	with	with	IN
cord-296347-fanlvxqs	904	44	t	t	NN
cord-296347-fanlvxqs	905	1	he	-PRON-	PRP
cord-296347-fanlvxqs	905	2	host	host	NN
cord-296347-fanlvxqs	905	3	plant	plant	NN
cord-296347-fanlvxqs	905	4	VIP	VIP	NNP
cord-296347-fanlvxqs	905	5	1	1	CD
cord-296347-fanlvxqs	905	6	pro	pro	NNP
cord-296347-fanlvxqs	905	7	tein	tein	NNP
cord-296347-fanlvxqs	905	8	,	,	,
cord-296347-fanlvxqs	905	9	assist	assist	VB
cord-296347-fanlvxqs	905	10	its	-PRON-	PRP$
cord-296347-fanlvxqs	905	11	nucl	nucl	NNP
cord-296347-fanlvxqs	905	12	ear	ear	NN
cord-296347-fanlvxqs	905	13	import	import	NN
cord-296347-fanlvxqs	905	14	(	(	-LRB-
cord-296347-fanlvxqs	905	15	Tzfira	Tzfira	NNP
cord-296347-fanlvxqs	905	16	et	et	NNP
cord-296347-fanlvxqs	905	17	al	al	NNP
cord-296347-fanlvxqs	905	18	.	.	NNP
cord-296347-fanlvxqs	905	19	,	,	,
cord-296347-fanlvxqs	905	20	2004	2004	CD
cord-296347-fanlvxqs	905	21	a	a	LS
cord-296347-fanlvxqs	905	22	)	)	-RRB-
cord-296347-fanlvxqs	905	23	.	.	.
cord-296347-fanlvxqs	906	1	Howeve	Howeve	NNP
cord-296347-fanlvxqs	906	2	r	r	NNP
cord-296347-fanlvxqs	906	3	,	,	,
cord-296347-fanlvxqs	906	4	di	di	NNP
cord-296347-fanlvxqs	906	5	sassembly	sassembly	RB
cord-296347-fanlvxqs	906	6	of	of	IN
cord-296347-fanlvxqs	906	7	this	this	DT
cord-296347-fanlvxqs	906	8	VirE2	VirE2	NNP
cord-296347-fanlvxqs	906	9	/	/	SYM
cord-296347-fanlvxqs	906	10	T	T	NNP
cord-296347-fanlvxqs	906	11	-	-	HYPH
cord-296347-fanlvxqs	906	12	DNA/	DNA/	NNP
cord-296347-fanlvxqs	906	13	VIP1	VIP1	NNP
cord-296347-fanlvxqs	906	14	complex	complex	NN
cord-296347-fanlvxqs	906	15	mus	mus	NNP
cord-296347-fanlvxqs	906	16	t	t	NN
cord-296347-fanlvxqs	906	17	occur	occur	VBP
cord-296347-fanlvxqs	906	18	before	before	RB
cord-296347-fanlvxqs	906	19	in	in	IN
cord-296347-fanlvxqs	906	20	tegration	tegration	NN
cord-296347-fanlvxqs	906	21	and	and	CC
cord-296347-fanlvxqs	906	22	involves	involve	VBZ
cord-296347-fanlvxqs	906	23	intranu	intranu	NNP
cord-296347-fanlvxqs	906	24	clear	clear	JJ
cord-296347-fanlvxqs	906	25	pro	pro	JJ
cord-296347-fanlvxqs	906	26	teolysis	teolysis	NN
cord-296347-fanlvxqs	906	27	of	of	IN
cord-296347-fanlvxqs	906	28	VirE2	VirE2	NNP
cord-296347-fanlvxqs	906	29	and	and	CC
cord-296347-fanlvxqs	906	30	VIP	VIP	NNP
cord-296347-fanlvxqs	906	31	1	1	CD
cord-296347-fanlvxqs	906	32	induced	induce	VBN
cord-296347-fanlvxqs	906	33	by	by	IN
cord-296347-fanlvxqs	906	34	the	the	DT
cord-296347-fanlvxqs	906	35	VirF	VirF	NNP
cord-296347-fanlvxqs	906	36	pro	pro	NNP
cord-296347-fanlvxqs	906	37	tein	tein	NNP
cord-296347-fanlvxqs	906	38	,	,	,
cord-296347-fanlvxqs	906	39	an	an	DT
cord-296347-fanlvxqs	906	40	Fboxdomain	Fboxdomain	NNP
cord-296347-fanlvxqs	906	41	-	-	HYPH
cord-296347-fanlvxqs	906	42	co	co	NNP
cord-296347-fanlvxqs	906	43	ntain	ntain	NNP
cord-296347-fanlvxqs	906	44	ing	ing	NNP
cord-296347-fanlvxqs	906	45	protein	protein	NN
cord-296347-fanlvxqs	906	46	.	.	.
cord-296347-fanlvxqs	907	1	T	T	NNP
cord-296347-fanlvxqs	908	1	he	-PRON-	PRP
cord-296347-fanlvxqs	908	2	bacte	bacte	NNP
cord-296347-fanlvxqs	908	3	rial	rial	NN
cord-296347-fanlvxqs	908	4	VirF	VirF	NNP
cord-296347-fanlvxqs	908	5	F	F	NNP
cord-296347-fanlvxqs	909	1	-box	-box	:
cord-296347-fanlvxqs	909	2	hi	hi	UH
cord-296347-fanlvxqs	909	3	jacks	jack	VBZ
cord-296347-fanlvxqs	909	4	the	the	DT
cord-296347-fanlvxqs	909	5	SCF	SCF	NNP
cord-296347-fanlvxqs	909	6	E3	E3	NNP
cord-296347-fanlvxqs	909	7	plant	plant	NN
cord-296347-fanlvxqs	909	8	homolog	homolog	NN
cord-296347-fanlvxqs	909	9	ue	ue	NNP
cord-296347-fanlvxqs	909	10	.	.	.
cord-296347-fanlvxqs	910	1	The	the	DT
cord-296347-fanlvxqs	910	2	VirF	VirF	NNP
cord-296347-fanlvxqs	910	3	-	-	:
cord-296347-fanlvxqs	910	4	contain	contain	VBP
cord-296347-fanlvxqs	910	5	ing	ing	DT
cord-296347-fanlvxqs	910	6	SCF	scf	NN
cord-296347-fanlvxqs	910	7	VirF	virf	NN
cord-296347-fanlvxqs	910	8	then	then	RB
cord-296347-fanlvxqs	910	9	leads	lead	VBZ
cord-296347-fanlvxqs	910	10	to	to	IN
cord-296347-fanlvxqs	910	11	degrad	degrad	NN
cord-296347-fanlvxqs	910	12	ation	ation	NN
cord-296347-fanlvxqs	910	13	of	of	IN
cord-296347-fanlvxqs	910	14	VIP1	VIP1	NNP
cord-296347-fanlvxqs	910	15	and	and	CC
cord-296347-fanlvxqs	910	16	VirE2	VirE2	NNP
cord-296347-fanlvxqs	910	17	,	,	,
cord-296347-fanlvxqs	910	18	and	and	CC
cord-296347-fanlvxqs	910	19	integration	integration	NN
cord-296347-fanlvxqs	910	20	of	of	IN
cord-296347-fanlvxqs	910	21	the	the	DT
cord-296347-fanlvxqs	910	22	Agrobact	Agrobact	NNP
cord-296347-fanlvxqs	910	23	erium	erium	NN
cord-296347-fanlvxqs	910	24	T	T	NNP
cord-296347-fanlvxqs	910	25	-	-	HYPH
cord-296347-fanlvxqs	910	26	DNA	DNA	NNP
cord-296347-fanlvxqs	910	27	(	(	-LRB-
cord-296347-fanlvxqs	911	1	Tzfira	Tzfira	NNP
cord-296347-fanlvxqs	911	2	et	et	NNP
cord-296347-fanlvxqs	911	3	al	al	NNP
cord-296347-fanlvxqs	911	4	.	.	NNP
cord-296347-fanlvxqs	911	5	,	,	,
cord-296347-fanlvxqs	911	6	2004b	2004b	CD
cord-296347-fanlvxqs	911	7	)	)	-RRB-
cord-296347-fanlvxqs	911	8	.	.	.
cord-296347-fanlvxqs	912	1	We	-PRON-	PRP
cord-296347-fanlvxqs	912	2	conside	conside	VBP
cord-296347-fanlvxqs	912	3	r	r	NN
cord-296347-fanlvxqs	913	1	it	-PRON-	PRP
cord-296347-fanlvxqs	913	2	unlikely	unlikely	JJ
cord-296347-fanlvxqs	913	3	that	that	IN
cord-296347-fanlvxqs	913	4	this	this	DT
cord-296347-fanlvxqs	913	5	pos	pos	NNP
cord-296347-fanlvxqs	913	6	sibility	sibility	NNP
cord-296347-fanlvxqs	913	7	has	have	VBZ
cord-296347-fanlvxqs	913	8	been	be	VBN
cord-296347-fanlvxqs	913	9	exploited	exploit	VBN
cord-296347-fanlvxqs	913	10	only	only	RB
cord-296347-fanlvxqs	913	11	by	by	IN
cord-296347-fanlvxqs	913	12	pl	pl	NNP
cord-296347-fanlvxqs	913	13	ant	ant	NNP
cord-296347-fanlvxqs	913	14	pathogens	pathogen	NNS
cord-296347-fanlvxqs	913	15	.	.	.
cord-296347-fanlvxqs	914	1	The	the	DT
cord-296347-fanlvxqs	914	2	h	h	FW
cord-296347-fanlvxqs	914	3	ost	ost	FW
cord-296347-fanlvxqs	914	4	innate	innate	JJ
cord-296347-fanlvxqs	914	5	response	response	NN
cord-296347-fanlvxqs	914	6	triggered	trigger	VBN
cord-296347-fanlvxqs	914	7	by	by	IN
cord-296347-fanlvxqs	914	8	type	type	NN
cord-296347-fanlvxqs	915	1	I	-PRON-	PRP
cord-296347-fanlvxqs	915	2	inter	inter	VBP
cord-296347-fanlvxqs	915	3	feron	feron	NNP
cord-296347-fanlvxqs	915	4	(	(	-LRB-
cord-296347-fanlvxqs	915	5	IFN	IFN	NNP
cord-296347-fanlvxqs	915	6	-	-	HYPH
cord-296347-fanlvxqs	915	7	a	a	NN
cord-296347-fanlvxqs	915	8	and	and	CC
cord-296347-fanlvxqs	915	9	-b	-b	ADD
cord-296347-fanlvxqs	915	10	)	)	-RRB-
cord-296347-fanlvxqs	916	1	innate	innate	JJ
cord-296347-fanlvxqs	916	2	response	response	NN
cord-296347-fanlvxqs	916	3	is	be	VBZ
cord-296347-fanlvxqs	916	4	crucial	crucial	JJ
cord-296347-fanlvxqs	916	5	in	in	IN
cord-296347-fanlvxqs	916	6	early	early	JJ
cord-296347-fanlvxqs	916	7	immunity	immunity	NN
cord-296347-fanlvxqs	916	8	against	against	IN
cord-296347-fanlvxqs	916	9	viruses	virus	NNS
cord-296347-fanlvxqs	916	10	,	,	,
cord-296347-fanlvxqs	916	11	bac	bac	NNP
cord-296347-fanlvxqs	916	12	teria	teria	NNP
cord-296347-fanlvxqs	916	13	,	,	,
cord-296347-fanlvxqs	916	14	and	and	CC
cord-296347-fanlvxqs	916	15	some	some	DT
cord-296347-fanlvxqs	916	16	parasites	parasite	NNS
cord-296347-fanlvxqs	916	17	,	,	,
cord-296347-fanlvxqs	916	18	acting	act	VBG
cord-296347-fanlvxqs	916	19	t	t	NN
cord-296347-fanlvxqs	916	20	o	o	NN
cord-296347-fanlvxqs	916	21	lim	lim	NNP
cord-296347-fanlvxqs	916	22	it	-PRON-	PRP
cord-296347-fanlvxqs	917	1	pathogen	pathogen	NN
cord-296347-fanlvxqs	917	2	i	i	NNP
cord-296347-fanlvxqs	917	3	n	n	CC
cord-296347-fanlvxqs	917	4	fection	fection	NNP
cord-296347-fanlvxqs	917	5	li	li	NNP
cord-296347-fanlvxqs	917	6	mi	mi	NNP
cord-296347-fanlvxqs	917	7	ting	ting	NNP
cord-296347-fanlvxqs	917	8	replic	replic	NNP
cord-296347-fanlvxqs	917	9	ation	ation	NN
cord-296347-fanlvxqs	917	10	of	of	IN
cord-296347-fanlvxqs	917	11	t	t	NN
cord-296347-fanlvxqs	918	1	he	-PRON-	PRP
cord-296347-fanlvxqs	918	2	pathogen	pathogen	NN
cord-296347-fanlvxqs	919	1	a	a	DT
cord-296347-fanlvxqs	919	2	nd	nd	NNP
cord-296347-fanlvxqs	919	3	constraining	constrain	VBG
cord-296347-fanlvxqs	919	4	cellular	cellular	JJ
cord-296347-fanlvxqs	919	5	permissiveness	permissiveness	NN
cord-296347-fanlvxqs	919	6	to	to	IN
cord-296347-fanlvxqs	919	7	infection	infection	NN
cord-296347-fanlvxqs	920	1	(	(	-LRB-
cord-296347-fanlvxqs	920	2	Smith	Smith	NNP
cord-296347-fanlvxqs	920	3	et	et	NNP
cord-296347-fanlvxqs	920	4	al	al	NNP
cord-296347-fanlvxqs	920	5	.	.	NNP
cord-296347-fanlvxqs	920	6	,	,	,
cord-296347-fanlvxqs	920	7	2005	2005	CD
cord-296347-fanlvxqs	920	8	)	)	-RRB-
cord-296347-fanlvxqs	920	9	.	.	.
cord-296347-fanlvxqs	921	1	Type	type	NN
cord-296347-fanlvxqs	921	2	I	-PRON-	PRP
cord-296347-fanlvxqs	921	3	interferon	interferon	NN
cord-296347-fanlvxqs	921	4	receptor	receptor	NN
cord-296347-fanlvxqs	921	5	signaling	signaling	NN
cord-296347-fanlvxqs	921	6	occurs	occur	VBZ
cord-296347-fanlvxqs	921	7	through	through	IN
cord-296347-fanlvxqs	921	8	the	the	DT
cord-296347-fanlvxqs	921	9	JAK	JAK	NNP
cord-296347-fanlvxqs	921	10	/	/	SYM
cord-296347-fanlvxqs	921	11	STAT	stat	NN
cord-296347-fanlvxqs	921	12	pathway	pathway	NN
cord-296347-fanlvxqs	921	13	and	and	CC
cord-296347-fanlvxqs	921	14	leads	lead	VBZ
cord-296347-fanlvxqs	921	15	to	to	IN
cord-296347-fanlvxqs	921	16	transcription	transcription	NN
cord-296347-fanlvxqs	921	17	of	of	IN
cord-296347-fanlvxqs	921	18	several	several	JJ
cord-296347-fanlvxqs	921	19	IFN	IFN	NNP
cord-296347-fanlvxqs	921	20	-	-	HYPH
cord-296347-fanlvxqs	921	21	stimulated	stimulate	VBN
cord-296347-fanlvxqs	921	22	genes	gene	NNS
cord-296347-fanlvxqs	921	23	(	(	-LRB-
cord-296347-fanlvxqs	921	24	ISGs	ISGs	NNP
cord-296347-fanlvxqs	921	25	)	)	-RRB-
cord-296347-fanlvxqs	921	26	,	,	,
cord-296347-fanlvxqs	921	27	of	of	IN
cord-296347-fanlvxqs	921	28	which	which	WDT
cord-296347-fanlvxqs	921	29	the	the	DT
cord-296347-fanlvxqs	921	30	gene	gene	NN
cord-296347-fanlvxqs	921	31	encoding	encode	VBG
cord-296347-fanlvxqs	921	32	the	the	DT
cord-296347-fanlvxqs	921	33	Ub	Ub	NNP
cord-296347-fanlvxqs	921	34	-	-	HYPH
cord-296347-fanlvxqs	921	35	like	like	JJ
cord-296347-fanlvxqs	921	36	modifier	modifier	NN
cord-296347-fanlvxqs	922	1	ISG15	ISG15	NNP
cord-296347-fanlvxqs	922	2	is	be	VBZ
cord-296347-fanlvxqs	922	3	one	one	CD
cord-296347-fanlvxqs	922	4	of	of	IN
cord-296347-fanlvxqs	922	5	the	the	DT
cord-296347-fanlvxqs	922	6	most	most	RBS
cord-296347-fanlvxqs	922	7	strongly	strongly	RB
cord-296347-fanlvxqs	922	8	induced	induce	VBN
cord-296347-fanlvxqs	922	9	(	(	-LRB-
cord-296347-fanlvxqs	922	10	Farrell	Farrell	NNP
cord-296347-fanlvxqs	922	11	et	et	NNP
cord-296347-fanlvxqs	922	12	al	al	NNP
cord-296347-fanlvxqs	922	13	.	.	NNP
cord-296347-fanlvxqs	922	14	,	,	,
cord-296347-fanlvxqs	922	15	1979	1979	CD
cord-296347-fanlvxqs	922	16	)	)	-RRB-
cord-296347-fanlvxqs	922	17	.	.	.
cord-296347-fanlvxqs	923	1	ISG15	ISG15	NNP
cord-296347-fanlvxqs	923	2	and	and	CC
cord-296347-fanlvxqs	923	3	protein	protein	NN
cord-296347-fanlvxqs	923	4	modification	modification	NN
cord-296347-fanlvxqs	923	5	by	by	IN
cord-296347-fanlvxqs	923	6	ISG15	ISG15	NNP
cord-296347-fanlvxqs	923	7	(	(	-LRB-
cord-296347-fanlvxqs	923	8	ISGylation	ISGylation	NNP
cord-296347-fanlvxqs	923	9	)	)	-RRB-
cord-296347-fanlvxqs	923	10	are	be	VBP
cord-296347-fanlvxqs	923	11	induced	induce	VBN
cord-296347-fanlvxqs	923	12	by	by	IN
cord-296347-fanlvxqs	923	13	viral	viral	JJ
cord-296347-fanlvxqs	923	14	and	and	CC
cord-296347-fanlvxqs	923	15	bacterial	bacterial	JJ
cord-296347-fanlvxqs	923	16	infection	infection	NN
cord-296347-fanlvxqs	923	17	or	or	CC
cord-296347-fanlvxqs	923	18	other	other	JJ
cord-296347-fanlvxqs	923	19	stresses	stress	NNS
cord-296347-fanlvxqs	923	20	,	,	,
cord-296347-fanlvxqs	923	21	suggesting	suggest	VBG
cord-296347-fanlvxqs	923	22	important	important	JJ
cord-296347-fanlvxqs	923	23	roles	role	NNS
cord-296347-fanlvxqs	923	24	for	for	IN
cord-296347-fanlvxqs	923	25	the	the	DT
cord-296347-fanlvxqs	923	26	ISG15	ISG15	NNP
cord-296347-fanlvxqs	923	27	system	system	NN
cord-296347-fanlvxqs	923	28	in	in	IN
cord-296347-fanlvxqs	923	29	innate	innate	JJ
cord-296347-fanlvxqs	923	30	immune	immune	JJ
cord-296347-fanlvxqs	923	31	responses	response	NNS
cord-296347-fanlvxqs	923	32	Ritchie	Ritchie	NNP
cord-296347-fanlvxqs	923	33	and	and	CC
cord-296347-fanlvxqs	923	34	Zhang	Zhang	NNP
cord-296347-fanlvxqs	923	35	,	,	,
cord-296347-fanlvxqs	923	36	2004	2004	CD
cord-296347-fanlvxqs	923	37	)	)	-RRB-
cord-296347-fanlvxqs	923	38	.	.	.
cord-296347-fanlvxqs	924	1	ISG15	ISG15	NNP
cord-296347-fanlvxqs	924	2	is	be	VBZ
cord-296347-fanlvxqs	924	3	conjugated	conjugate	VBN
cord-296347-fanlvxqs	924	4	onto	onto	IN
cord-296347-fanlvxqs	924	5	several	several	JJ
cord-296347-fanlvxqs	924	6	signaling	signal	VBG
cord-296347-fanlvxqs	924	7	molecules	molecule	NNS
cord-296347-fanlvxqs	924	8	with	with	IN
cord-296347-fanlvxqs	924	9	immunomodulatory	immunomodulatory	JJ
cord-296347-fanlvxqs	924	10	functions	function	NNS
cord-296347-fanlvxqs	924	11	,	,	,
cord-296347-fanlvxqs	924	12	like	like	IN
cord-296347-fanlvxqs	924	13	JAK	JAK	NNP
cord-296347-fanlvxqs	924	14	/	/	SYM
cord-296347-fanlvxqs	924	15	STAT	stat	NN
cord-296347-fanlvxqs	924	16	proteins	protein	NNS
cord-296347-fanlvxqs	924	17	(	(	-LRB-
cord-296347-fanlvxqs	924	18	Giannakopoulos	Giannakopoulos	NNP
cord-296347-fanlvxqs	924	19	et	et	FW
cord-296347-fanlvxqs	924	20	al	al	NNP
cord-296347-fanlvxqs	924	21	.	.	NNP
cord-296347-fanlvxqs	924	22	,	,	,
cord-296347-fanlvxqs	924	23	2005	2005	CD
cord-296347-fanlvxqs	924	24	;	;	:
cord-296347-fanlvxqs	925	1	Malakhov	Malakhov	NNP
cord-296347-fanlvxqs	925	2	et	et	NNP
cord-296347-fanlvxqs	925	3	al	al	NNP
cord-296347-fanlvxqs	925	4	.	.	NNP
cord-296347-fanlvxqs	925	5	,	,	,
cord-296347-fanlvxqs	925	6	2003	2003	CD
cord-296347-fanlvxqs	925	7	)	)	-RRB-
cord-296347-fanlvxqs	925	8	.	.	.
cord-296347-fanlvxqs	926	1	The	the	DT
cord-296347-fanlvxqs	926	2	ISGylation	isgylation	NN
cord-296347-fanlvxqs	926	3	cascade	cascade	NN
cord-296347-fanlvxqs	926	4	is	be	VBZ
cord-296347-fanlvxqs	926	5	initiated	initiate	VBN
cord-296347-fanlvxqs	926	6	by	by	IN
cord-296347-fanlvxqs	926	7	ISG15	ISG15	NNP
cord-296347-fanlvxqs	926	8	activation	activation	NN
cord-296347-fanlvxqs	926	9	by	by	IN
cord-296347-fanlvxqs	926	10	an	an	DT
cord-296347-fanlvxqs	926	11	E1-like	E1-like	NNP
cord-296347-fanlvxqs	926	12	enzyme	enzyme	NN
cord-296347-fanlvxqs	926	13	,	,	,
cord-296347-fanlvxqs	926	14	UBE1L	ube1l	NN
cord-296347-fanlvxqs	926	15	,	,	,
cord-296347-fanlvxqs	926	16	transfer	transfer	VB
cord-296347-fanlvxqs	926	17	to	to	IN
cord-296347-fanlvxqs	926	18	the	the	DT
cord-296347-fanlvxqs	926	19	ISG	ISG	NNP
cord-296347-fanlvxqs	926	20	-	-	HYPH
cord-296347-fanlvxqs	926	21	conjugating	conjugate	VBG
cord-296347-fanlvxqs	926	22	UBCH8	ubch8	NN
cord-296347-fanlvxqs	926	23	enzyme	enzyme	NN
cord-296347-fanlvxqs	926	24	,	,	,
cord-296347-fanlvxqs	926	25	and	and	CC
cord-296347-fanlvxqs	926	26	incorporation	incorporation	NN
cord-296347-fanlvxqs	926	27	into	into	IN
cord-296347-fanlvxqs	926	28	UBCH8-compatible	ubch8-compatible	JJ
cord-296347-fanlvxqs	926	29	Ub	Ub	NNP
cord-296347-fanlvxqs	926	30	E3	e3	NN
cord-296347-fanlvxqs	926	31	ligases	ligase	NNS
cord-296347-fanlvxqs	926	32	(	(	-LRB-
cord-296347-fanlvxqs	926	33	Dastur	Dastur	NNP
cord-296347-fanlvxqs	926	34	et	et	NNP
cord-296347-fanlvxqs	926	35	al	al	NNP
cord-296347-fanlvxqs	926	36	.	.	NNP
cord-296347-fanlvxqs	926	37	,	,	,
cord-296347-fanlvxqs	926	38	2006	2006	CD
cord-296347-fanlvxqs	926	39	;	;	:
cord-296347-fanlvxqs	926	40	Zou	Zou	NNP
cord-296347-fanlvxqs	926	41	and	and	CC
cord-296347-fanlvxqs	926	42	Zhang	Zhang	NNP
cord-296347-fanlvxqs	926	43	,	,	,
cord-296347-fanlvxqs	926	44	2006	2006	CD
cord-296347-fanlvxqs	926	45	)	)	-RRB-
cord-296347-fanlvxqs	926	46	.	.	.
cord-296347-fanlvxqs	927	1	A	a	DT
cord-296347-fanlvxqs	927	2	deISGylating	deisgylate	VBG
cord-296347-fanlvxqs	927	3	enzyme	enzyme	NN
cord-296347-fanlvxqs	927	4	,	,	,
cord-296347-fanlvxqs	927	5	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	927	6	-	-	HYPH
cord-296347-fanlvxqs	927	7	binding	bind	VBG
cord-296347-fanlvxqs	927	8	protein	protein	NN
cord-296347-fanlvxqs	927	9	43	43	CD
cord-296347-fanlvxqs	927	10	(	(	-LRB-
cord-296347-fanlvxqs	927	11	UBP43	UBP43	NNP
cord-296347-fanlvxqs	927	12	)	)	-RRB-
cord-296347-fanlvxqs	927	13	,	,	,
cord-296347-fanlvxqs	927	14	also	also	RB
cord-296347-fanlvxqs	927	15	called	call	VBN
cord-296347-fanlvxqs	927	16	USP18	USP18	NNP
cord-296347-fanlvxqs	927	17	,	,	,
cord-296347-fanlvxqs	927	18	specifically	specifically	RB
cord-296347-fanlvxqs	927	19	removes	remove	VBZ
cord-296347-fanlvxqs	927	20	ISG15	isg15	NN
cord-296347-fanlvxqs	927	21	from	from	IN
cord-296347-fanlvxqs	927	22	ISGylated	isgylate	VBN
cord-296347-fanlvxqs	927	23	substrates	substrate	NNS
cord-296347-fanlvxqs	927	24	,	,	,
cord-296347-fanlvxqs	927	25	and	and	CC
cord-296347-fanlvxqs	927	26	is	be	VBZ
cord-296347-fanlvxqs	927	27	regulated	regulate	VBN
cord-296347-fanlvxqs	927	28	by	by	IN
cord-296347-fanlvxqs	927	29	ubiquitination	ubiquitination	NN
cord-296347-fanlvxqs	927	30	by	by	IN
cord-296347-fanlvxqs	927	31	the	the	DT
cord-296347-fanlvxqs	927	32	SCF	SCF	NNP
cord-296347-fanlvxqs	927	33	Skp2	Skp2	NNP
cord-296347-fanlvxqs	927	34	E3	E3	NNP
cord-296347-fanlvxqs	927	35	(	(	-LRB-
cord-296347-fanlvxqs	927	36	Tokarz	Tokarz	NNP
cord-296347-fanlvxqs	927	37	et	et	NNP
cord-296347-fanlvxqs	927	38	al	al	NNP
cord-296347-fanlvxqs	927	39	.	.	NNP
cord-296347-fanlvxqs	927	40	,	,	,
cord-296347-fanlvxqs	927	41	2004	2004	CD
cord-296347-fanlvxqs	927	42	)	)	-RRB-
cord-296347-fanlvxqs	927	43	.	.	.
cord-296347-fanlvxqs	928	1	USP18	usp18	JJ
cord-296347-fanlvxqs	928	2	is	be	VBZ
cord-296347-fanlvxqs	928	3	unlikely	unlikely	JJ
cord-296347-fanlvxqs	928	4	to	to	TO
cord-296347-fanlvxqs	928	5	be	be	VB
cord-296347-fanlvxqs	928	6	the	the	DT
cord-296347-fanlvxqs	928	7	sole	sole	JJ
cord-296347-fanlvxqs	928	8	enzyme	enzyme	NN
cord-296347-fanlvxqs	928	9	capable	capable	JJ
cord-296347-fanlvxqs	928	10	of	of	IN
cord-296347-fanlvxqs	928	11	acting	act	VBG
cord-296347-fanlvxqs	928	12	on	on	IN
cord-296347-fanlvxqs	928	13	ISG15	ISG15	NNP
cord-296347-fanlvxqs	928	14	conjugates	conjugate	NNS
cord-296347-fanlvxqs	928	15	.	.	.
cord-296347-fanlvxqs	929	1	The	the	DT
cord-296347-fanlvxqs	929	2	role	role	NN
cord-296347-fanlvxqs	929	3	of	of	IN
cord-296347-fanlvxqs	929	4	ISG15	isg15	NN
cord-296347-fanlvxqs	929	5	in	in	IN
cord-296347-fanlvxqs	929	6	orchestration	orchestration	NN
cord-296347-fanlvxqs	929	7	of	of	IN
cord-296347-fanlvxqs	929	8	the	the	DT
cord-296347-fanlvxqs	929	9	innate	innate	JJ
cord-296347-fanlvxqs	929	10	antiviral	antiviral	JJ
cord-296347-fanlvxqs	929	11	response	response	NN
cord-296347-fanlvxqs	929	12	sets	set	VBZ
cord-296347-fanlvxqs	929	13	the	the	DT
cord-296347-fanlvxqs	929	14	ground	ground	NN
cord-296347-fanlvxqs	929	15	for	for	IN
cord-296347-fanlvxqs	929	16	pathogen	pathogen	NN
cord-296347-fanlvxqs	929	17	interference	interference	NN
cord-296347-fanlvxqs	929	18	.	.	.
cord-296347-fanlvxqs	930	1	Although	although	IN
cord-296347-fanlvxqs	930	2	the	the	DT
cord-296347-fanlvxqs	930	3	mechanism	mechanism	NN
cord-296347-fanlvxqs	930	4	is	be	VBZ
cord-296347-fanlvxqs	930	5	unclear	unclear	JJ
cord-296347-fanlvxqs	930	6	,	,	,
cord-296347-fanlvxqs	930	7	viral	viral	JJ
cord-296347-fanlvxqs	930	8	replication	replication	NN
cord-296347-fanlvxqs	930	9	in	in	IN
cord-296347-fanlvxqs	930	10	UBP43	UBP43	NNP
cord-296347-fanlvxqs	930	11	knockout	knockout	NN
cord-296347-fanlvxqs	930	12	mice	mouse	NNS
cord-296347-fanlvxqs	930	13	is	be	VBZ
cord-296347-fanlvxqs	930	14	impaired	impair	VBN
cord-296347-fanlvxqs	930	15	,	,	,
cord-296347-fanlvxqs	930	16	a	a	DT
cord-296347-fanlvxqs	930	17	phenotype	phenotype	NN
cord-296347-fanlvxqs	930	18	that	that	WDT
cord-296347-fanlvxqs	930	19	was	be	VBD
cord-296347-fanlvxqs	930	20	initially	initially	RB
cord-296347-fanlvxqs	930	21	attributed	attribute	VBN
cord-296347-fanlvxqs	930	22	to	to	IN
cord-296347-fanlvxqs	930	23	inhibition	inhibition	NN
cord-296347-fanlvxqs	930	24	of	of	IN
cord-296347-fanlvxqs	930	25	deISGylation	deisgylation	NN
cord-296347-fanlvxqs	930	26	and	and	CC
cord-296347-fanlvxqs	930	27	deregulation	deregulation	NN
cord-296347-fanlvxqs	930	28	of	of	IN
cord-296347-fanlvxqs	930	29	STAT	stat	NN
cord-296347-fanlvxqs	930	30	signaling	signal	VBG
cord-296347-fanlvxqs	930	31	.	.	.
cord-296347-fanlvxqs	931	1	There	there	EX
cord-296347-fanlvxqs	931	2	are	be	VBP
cord-296347-fanlvxqs	931	3	conflicting	conflict	VBG
cord-296347-fanlvxqs	931	4	views	view	NNS
cord-296347-fanlvxqs	931	5	on	on	IN
cord-296347-fanlvxqs	931	6	this	this	DT
cord-296347-fanlvxqs	932	1	(	(	-LRB-
cord-296347-fanlvxqs	932	2	Dao	Dao	NNP
cord-296347-fanlvxqs	932	3	and	and	CC
cord-296347-fanlvxqs	932	4	Zhang	Zhang	NNP
cord-296347-fanlvxqs	932	5	,	,	,
cord-296347-fanlvxqs	932	6	2005	2005	CD
cord-296347-fanlvxqs	932	7	;	;	:
cord-296347-fanlvxqs	933	1	Kim	Kim	NNP
cord-296347-fanlvxqs	933	2	et	et	NNP
cord-296347-fanlvxqs	933	3	al	al	NNP
cord-296347-fanlvxqs	933	4	.	.	.
cord-296347-fanlvxqs	934	1	,	,	,
cord-296347-fanlvxqs	934	2	2006b	2006b	CD
cord-296347-fanlvxqs	934	3	;	;	:
cord-296347-fanlvxqs	934	4	Knobeloch	Knobeloch	NNP
cord-296347-fanlvxqs	934	5	et	et	NNP
cord-296347-fanlvxqs	934	6	al	al	NNP
cord-296347-fanlvxqs	934	7	.	.	NNP
cord-296347-fanlvxqs	934	8	,	,	,
cord-296347-fanlvxqs	934	9	2005	2005	CD
cord-296347-fanlvxqs	934	10	)	)	-RRB-
cord-296347-fanlvxqs	934	11	and	and	CC
cord-296347-fanlvxqs	934	12	UBP43	UBP43	NNP
cord-296347-fanlvxqs	935	1	may	may	MD
cord-296347-fanlvxqs	935	2	in	in	IN
cord-296347-fanlvxqs	935	3	fact	fact	NN
cord-296347-fanlvxqs	935	4	inhibit	inhibit	VB
cord-296347-fanlvxqs	935	5	type	type	NN
cord-296347-fanlvxqs	936	1	I	-PRON-	PRP
cord-296347-fanlvxqs	936	2	IFN	IFN	NNP
cord-296347-fanlvxqs	936	3	signaling	signal	VBG
cord-296347-fanlvxqs	936	4	irrespectively	irrespectively	RB
cord-296347-fanlvxqs	936	5	of	of	IN
cord-296347-fanlvxqs	936	6	its	-PRON-	PRP$
cord-296347-fanlvxqs	936	7	ISG15	isg15	NN
cord-296347-fanlvxqs	936	8	isopeptidase	isopeptidase	IN
cord-296347-fanlvxqs	936	9	activity	activity	NN
cord-296347-fanlvxqs	936	10	,	,	,
cord-296347-fanlvxqs	936	11	by	by	IN
cord-296347-fanlvxqs	936	12	binding	bind	VBG
cord-296347-fanlvxqs	936	13	to	to	IN
cord-296347-fanlvxqs	936	14	the	the	DT
cord-296347-fanlvxqs	936	15	IFN	IFN	NNP
cord-296347-fanlvxqs	936	16	receptor	receptor	NN
cord-296347-fanlvxqs	936	17	and	and	CC
cord-296347-fanlvxqs	936	18	blocking	block	VBG
cord-296347-fanlvxqs	936	19	the	the	DT
cord-296347-fanlvxqs	936	20	interaction	interaction	NN
cord-296347-fanlvxqs	936	21	between	between	IN
cord-296347-fanlvxqs	936	22	JAK	JAK	NNP
cord-296347-fanlvxqs	936	23	and	and	CC
cord-296347-fanlvxqs	936	24	the	the	DT
cord-296347-fanlvxqs	936	25	IFN	IFN	NNP
cord-296347-fanlvxqs	936	26	receptor	receptor	NN
cord-296347-fanlvxqs	936	27	(	(	-LRB-
cord-296347-fanlvxqs	936	28	Malakhova	Malakhova	NNP
cord-296347-fanlvxqs	936	29	et	et	NNP
cord-296347-fanlvxqs	936	30	al	al	NNP
cord-296347-fanlvxqs	936	31	.	.	NNP
cord-296347-fanlvxqs	936	32	,	,	,
cord-296347-fanlvxqs	936	33	2006	2006	CD
cord-296347-fanlvxqs	936	34	)	)	-RRB-
cord-296347-fanlvxqs	936	35	.	.	.
cord-296347-fanlvxqs	937	1	IFN	IFN	NNP
cord-296347-fanlvxqs	937	2	-	-	HYPH
cord-296347-fanlvxqs	937	3	mediated	mediate	VBN
cord-296347-fanlvxqs	937	4	inhibition	inhibition	NN
cord-296347-fanlvxqs	937	5	of	of	IN
cord-296347-fanlvxqs	937	6	HIV	HIV	NNP
cord-296347-fanlvxqs	937	7	replication	replication	NN
cord-296347-fanlvxqs	937	8	and	and	CC
cord-296347-fanlvxqs	937	9	budding	budding	NN
cord-296347-fanlvxqs	937	10	is	be	VBZ
cord-296347-fanlvxqs	937	11	dependent	dependent	JJ
cord-296347-fanlvxqs	937	12	on	on	IN
cord-296347-fanlvxqs	937	13	ISG15	isg15	NN
cord-296347-fanlvxqs	937	14	(	(	-LRB-
cord-296347-fanlvxqs	937	15	Kunzi	Kunzi	NNP
cord-296347-fanlvxqs	937	16	and	and	CC
cord-296347-fanlvxqs	937	17	Pitha	Pitha	NNP
cord-296347-fanlvxqs	937	18	,	,	,
cord-296347-fanlvxqs	937	19	1996	1996	CD
cord-296347-fanlvxqs	937	20	;	;	:
cord-296347-fanlvxqs	937	21	Pitha	Pitha	NNP
cord-296347-fanlvxqs	937	22	,	,	,
cord-296347-fanlvxqs	937	23	1994	1994	CD
cord-296347-fanlvxqs	937	24	;	;	.
cord-296347-fanlvxqs	938	1	Poli	Poli	NNP
cord-296347-fanlvxqs	938	2	et	et	NNP
cord-296347-fanlvxqs	938	3	al	al	NNP
cord-296347-fanlvxqs	938	4	.	.	NNP
cord-296347-fanlvxqs	938	5	,	,	,
cord-296347-fanlvxqs	938	6	1989	1989	CD
cord-296347-fanlvxqs	938	7	)	)	-RRB-
cord-296347-fanlvxqs	938	8	.	.	.
cord-296347-fanlvxqs	939	1	Expression	expression	NN
cord-296347-fanlvxqs	939	2	of	of	IN
cord-296347-fanlvxqs	939	3	ISG15	isg15	NN
cord-296347-fanlvxqs	939	4	inhibits	inhibit	VBZ
cord-296347-fanlvxqs	939	5	ubiquitination	ubiquitination	NN
cord-296347-fanlvxqs	939	6	of	of	IN
cord-296347-fanlvxqs	939	7	the	the	DT
cord-296347-fanlvxqs	939	8	HIV-1	HIV-1	NNP
cord-296347-fanlvxqs	939	9	Gag	Gag	NNP
cord-296347-fanlvxqs	939	10	protein	protein	NN
cord-296347-fanlvxqs	939	11	and	and	CC
cord-296347-fanlvxqs	939	12	TSG101	TSG101	NNP
cord-296347-fanlvxqs	939	13	,	,	,
cord-296347-fanlvxqs	939	14	and	and	CC
cord-296347-fanlvxqs	939	15	disrupts	disrupt	VBZ
cord-296347-fanlvxqs	939	16	the	the	DT
cord-296347-fanlvxqs	939	17	interaction	interaction	NN
cord-296347-fanlvxqs	939	18	of	of	IN
cord-296347-fanlvxqs	939	19	the	the	DT
cord-296347-fanlvxqs	939	20	Gag	Gag	NNP
cord-296347-fanlvxqs	939	21	late	late	JJ
cord-296347-fanlvxqs	939	22	budding	bud	VBG
cord-296347-fanlvxqs	939	23	domain	domain	NN
cord-296347-fanlvxqs	939	24	with	with	IN
cord-296347-fanlvxqs	939	25	TSG101	TSG101	NNP
cord-296347-fanlvxqs	940	1	(	(	-LRB-
cord-296347-fanlvxqs	940	2	Okumura	Okumura	NNP
cord-296347-fanlvxqs	940	3	et	et	NNP
cord-296347-fanlvxqs	940	4	al	al	NNP
cord-296347-fanlvxqs	940	5	.	.	NNP
cord-296347-fanlvxqs	940	6	,	,	,
cord-296347-fanlvxqs	940	7	2006	2006	CD
cord-296347-fanlvxqs	940	8	)	)	-RRB-
cord-296347-fanlvxqs	940	9	.	.	.
cord-296347-fanlvxqs	941	1	Either	either	CC
cord-296347-fanlvxqs	941	2	of	of	IN
cord-296347-fanlvxqs	941	3	these	these	DT
cord-296347-fanlvxqs	941	4	ISG15	isg15	NN
cord-296347-fanlvxqs	941	5	effects	effect	NNS
cord-296347-fanlvxqs	941	6	and/or	and/or	CC
cord-296347-fanlvxqs	941	7	additional	additional	JJ
cord-296347-fanlvxqs	941	8	mechanisms	mechanism	NNS
cord-296347-fanlvxqs	941	9	of	of	IN
cord-296347-fanlvxqs	941	10	action	action	NN
cord-296347-fanlvxqs	941	11	could	could	MD
cord-296347-fanlvxqs	941	12	lead	lead	VB
cord-296347-fanlvxqs	941	13	to	to	IN
cord-296347-fanlvxqs	941	14	failure	failure	NN
cord-296347-fanlvxqs	941	15	to	to	TO
cord-296347-fanlvxqs	941	16	recruit	recruit	VB
cord-296347-fanlvxqs	941	17	ESCRT	ESCRT	NNP
cord-296347-fanlvxqs	941	18	complexes	complex	NNS
cord-296347-fanlvxqs	941	19	and	and	CC
cord-296347-fanlvxqs	941	20	inhibition	inhibition	NN
cord-296347-fanlvxqs	941	21	of	of	IN
cord-296347-fanlvxqs	941	22	HIV	HIV	NNP
cord-296347-fanlvxqs	941	23	budding	bud	VBG
cord-296347-fanlvxqs	941	24	.	.	.
cord-296347-fanlvxqs	942	1	ISG15	ISG15	NNP
cord-296347-fanlvxqs	942	2	is	be	VBZ
cord-296347-fanlvxqs	942	3	strongly	strongly	RB
cord-296347-fanlvxqs	942	4	induced	induce	VBN
cord-296347-fanlvxqs	942	5	by	by	IN
cord-296347-fanlvxqs	942	6	infection	infection	NN
cord-296347-fanlvxqs	942	7	with	with	IN
cord-296347-fanlvxqs	942	8	influenza	influenza	NN
cord-296347-fanlvxqs	942	9	B	B	NNP
cord-296347-fanlvxqs	942	10	virus	virus	NN
cord-296347-fanlvxqs	942	11	.	.	.
cord-296347-fanlvxqs	943	1	The	the	DT
cord-296347-fanlvxqs	943	2	exact	exact	JJ
cord-296347-fanlvxqs	943	3	cellular	cellular	JJ
cord-296347-fanlvxqs	943	4	function	function	NN
cord-296347-fanlvxqs	943	5	and	and	CC
cord-296347-fanlvxqs	943	6	targets	target	NNS
cord-296347-fanlvxqs	943	7	of	of	IN
cord-296347-fanlvxqs	943	8	ISG15	isg15	NN
cord-296347-fanlvxqs	943	9	are	be	VBP
cord-296347-fanlvxqs	943	10	not	not	RB
cord-296347-fanlvxqs	943	11	known	know	VBN
cord-296347-fanlvxqs	943	12	,	,	,
cord-296347-fanlvxqs	943	13	but	but	CC
cord-296347-fanlvxqs	943	14	the	the	DT
cord-296347-fanlvxqs	943	15	NS1	ns1	NN
cord-296347-fanlvxqs	943	16	protein	protein	NN
cord-296347-fanlvxqs	943	17	of	of	IN
cord-296347-fanlvxqs	943	18	influenza	influenza	NN
cord-296347-fanlvxqs	943	19	B	b	NN
cord-296347-fanlvxqs	943	20	viruses	virus	NNS
cord-296347-fanlvxqs	943	21	(	(	-LRB-
cord-296347-fanlvxqs	943	22	NS1B	NS1B	NNP
cord-296347-fanlvxqs	943	23	)	)	-RRB-
cord-296347-fanlvxqs	943	24	blocks	block	VBZ
cord-296347-fanlvxqs	943	25	its	-PRON-	PRP$
cord-296347-fanlvxqs	943	26	conjugation	conjugation	NN
cord-296347-fanlvxqs	943	27	to	to	TO
cord-296347-fanlvxqs	943	28	target	target	VB
cord-296347-fanlvxqs	943	29	proteins	protein	NNS
cord-296347-fanlvxqs	943	30	:	:	:
cord-296347-fanlvxqs	943	31	the	the	DT
cord-296347-fanlvxqs	943	32	NS1B	NS1B	NNP
cord-296347-fanlvxqs	943	33	N	N	NNP
cord-296347-fanlvxqs	943	34	-	-	HYPH
cord-296347-fanlvxqs	943	35	terminus	terminus	NN
cord-296347-fanlvxqs	943	36	binds	bind	VBZ
cord-296347-fanlvxqs	943	37	ISG15	isg15	NN
cord-296347-fanlvxqs	943	38	,	,	,
cord-296347-fanlvxqs	943	39	inhibiting	inhibit	VBG
cord-296347-fanlvxqs	943	40	activation	activation	NN
cord-296347-fanlvxqs	943	41	of	of	IN
cord-296347-fanlvxqs	943	42	ISG15	isg15	NN
cord-296347-fanlvxqs	943	43	by	by	IN
cord-296347-fanlvxqs	943	44	its	-PRON-	PRP$
cord-296347-fanlvxqs	943	45	E1	e1	NN
cord-296347-fanlvxqs	943	46	enzyme	enzyme	NN
cord-296347-fanlvxqs	943	47	,	,	,
cord-296347-fanlvxqs	943	48	UBE1L.	ube1l.	JJ
cord-296347-fanlvxqs	943	49	Influenza	Influenza	NNP
cord-296347-fanlvxqs	943	50	A	a	DT
cord-296347-fanlvxqs	943	51	viruses	virus	NNS
cord-296347-fanlvxqs	943	52	also	also	RB
cord-296347-fanlvxqs	943	53	manipulate	manipulate	VBP
cord-296347-fanlvxqs	943	54	cellular	cellular	JJ
cord-296347-fanlvxqs	943	55	ISGylation	isgylation	NN
cord-296347-fanlvxqs	943	56	processes	process	NNS
cord-296347-fanlvxqs	943	57	,	,	,
cord-296347-fanlvxqs	943	58	through	through	IN
cord-296347-fanlvxqs	943	59	an	an	DT
cord-296347-fanlvxqs	943	60	even	even	RB
cord-296347-fanlvxqs	943	61	less	less	RBR
cord-296347-fanlvxqs	943	62	well	well	RB
cord-296347-fanlvxqs	943	63	characterized	characterize	VBN
cord-296347-fanlvxqs	943	64	mechanism	mechanism	NN
cord-296347-fanlvxqs	943	65	:	:	:
cord-296347-fanlvxqs	943	66	the	the	DT
cord-296347-fanlvxqs	943	67	influenza	influenza	NN
cord-296347-fanlvxqs	943	68	A	a	DT
cord-296347-fanlvxqs	943	69	virus	virus	NN
cord-296347-fanlvxqs	944	1	NS1A	NS1A	NNP
cord-296347-fanlvxqs	945	1	protein	protein	NN
cord-296347-fanlvxqs	945	2	does	do	VBZ
cord-296347-fanlvxqs	945	3	not	not	RB
cord-296347-fanlvxqs	945	4	directly	directly	RB
cord-296347-fanlvxqs	945	5	bind	bind	VB
cord-296347-fanlvxqs	945	6	the	the	DT
cord-296347-fanlvxqs	945	7	ISG15	ISG15	NNP
cord-296347-fanlvxqs	945	8	protein	protein	NN
cord-296347-fanlvxqs	945	9	,	,	,
cord-296347-fanlvxqs	945	10	but	but	CC
cord-296347-fanlvxqs	945	11	little	little	JJ
cord-296347-fanlvxqs	945	12	or	or	CC
cord-296347-fanlvxqs	945	13	no	no	DT
cord-296347-fanlvxqs	945	14	ISG15	ISG15	NNP
cord-296347-fanlvxqs	945	15	protein	protein	NN
cord-296347-fanlvxqs	945	16	is	be	VBZ
cord-296347-fanlvxqs	945	17	produced	produce	VBN
cord-296347-fanlvxqs	945	18	during	during	IN
cord-296347-fanlvxqs	945	19	infection	infection	NN
cord-296347-fanlvxqs	945	20	(	(	-LRB-
cord-296347-fanlvxqs	945	21	Yuan	Yuan	NNP
cord-296347-fanlvxqs	945	22	and	and	CC
cord-296347-fanlvxqs	945	23	Krug	Krug	NNP
cord-296347-fanlvxqs	945	24	,	,	,
cord-296347-fanlvxqs	945	25	2001	2001	CD
cord-296347-fanlvxqs	945	26	;	;	:
cord-296347-fanlvxqs	946	1	Yuan	Yuan	NNP
cord-296347-fanlvxqs	946	2	et	et	FW
cord-296347-fanlvxqs	946	3	al	al	NNP
cord-296347-fanlvxqs	946	4	.	.	NNP
cord-296347-fanlvxqs	946	5	,	,	,
cord-296347-fanlvxqs	946	6	2002	2002	CD
cord-296347-fanlvxqs	946	7	)	)	-RRB-
cord-296347-fanlvxqs	946	8	.	.	.
cord-296347-fanlvxqs	947	1	Whether	whether	IN
cord-296347-fanlvxqs	947	2	this	this	DT
cord-296347-fanlvxqs	947	3	reflects	reflect	VBZ
cord-296347-fanlvxqs	947	4	ISGylation	isgylation	NN
cord-296347-fanlvxqs	947	5	,	,	,
cord-296347-fanlvxqs	947	6	deISGylation	deisgylation	NN
cord-296347-fanlvxqs	947	7	,	,	,
cord-296347-fanlvxqs	947	8	and/or	and/or	CC
cord-296347-fanlvxqs	947	9	UBP43	UBP43	VBG
cord-296347-fanlvxqs	947	10	ubiquitination	ubiquitination	NN
cord-296347-fanlvxqs	947	11	-	-	HYPH
cord-296347-fanlvxqs	947	12	mediated	mediate	VBN
cord-296347-fanlvxqs	947	13	control	control	NN
cord-296347-fanlvxqs	947	14	of	of	IN
cord-296347-fanlvxqs	947	15	the	the	DT
cord-296347-fanlvxqs	947	16	IFN	IFN	NNP
cord-296347-fanlvxqs	947	17	innate	innate	JJ
cord-296347-fanlvxqs	947	18	immune	immune	JJ
cord-296347-fanlvxqs	947	19	response	response	NN
cord-296347-fanlvxqs	947	20	is	be	VBZ
cord-296347-fanlvxqs	947	21	so	so	RB
cord-296347-fanlvxqs	947	22	far	far	RB
cord-296347-fanlvxqs	947	23	unknown	unknown	JJ
cord-296347-fanlvxqs	947	24	.	.	.
cord-296347-fanlvxqs	948	1	Suppression	suppression	NN
cord-296347-fanlvxqs	948	2	of	of	IN
cord-296347-fanlvxqs	948	3	NF	NF	NNP
cord-296347-fanlvxqs	948	4	-	-	HYPH
cord-296347-fanlvxqs	948	5	kB	kB	NNP
cord-296347-fanlvxqs	948	6	signaling	signaling	NN
cord-296347-fanlvxqs	948	7	is	be	VBZ
cord-296347-fanlvxqs	948	8	a	a	DT
cord-296347-fanlvxqs	948	9	common	common	JJ
cord-296347-fanlvxqs	948	10	theme	theme	NN
cord-296347-fanlvxqs	948	11	for	for	IN
cord-296347-fanlvxqs	948	12	many	many	JJ
cord-296347-fanlvxqs	948	13	viral	viral	JJ
cord-296347-fanlvxqs	948	14	as	as	RB
cord-296347-fanlvxqs	948	15	well	well	RB
cord-296347-fanlvxqs	948	16	as	as	IN
cord-296347-fanlvxqs	948	17	bacterial	bacterial	JJ
cord-296347-fanlvxqs	948	18	pathogens	pathogen	NNS
cord-296347-fanlvxqs	948	19	and	and	CC
cord-296347-fanlvxqs	948	20	can	can	MD
cord-296347-fanlvxqs	948	21	be	be	VB
cord-296347-fanlvxqs	948	22	certainly	certainly	RB
cord-296347-fanlvxqs	948	23	achieved	achieve	VBN
cord-296347-fanlvxqs	948	24	through	through	IN
cord-296347-fanlvxqs	948	25	modulation	modulation	NN
cord-296347-fanlvxqs	948	26	of	of	IN
cord-296347-fanlvxqs	948	27	Ub	ub	JJ
cord-296347-fanlvxqs	948	28	-	-	HYPH
cord-296347-fanlvxqs	948	29	dependent	dependent	JJ
cord-296347-fanlvxqs	948	30	events	event	NNS
cord-296347-fanlvxqs	948	31	in	in	IN
cord-296347-fanlvxqs	948	32	the	the	DT
cord-296347-fanlvxqs	948	33	NF	NF	NNP
cord-296347-fanlvxqs	948	34	-	-	HYPH
cord-296347-fanlvxqs	948	35	kB	kb	CD
cord-296347-fanlvxqs	948	36	cascade	cascade	NN
cord-296347-fanlvxqs	949	1	(	(	-LRB-
cord-296347-fanlvxqs	949	2	Bowie	Bowie	NNP
cord-296347-fanlvxqs	949	3	et	et	NNP
cord-296347-fanlvxqs	949	4	al	al	NNP
cord-296347-fanlvxqs	949	5	.	.	.
cord-296347-fanlvxqs	950	1	,	,	,
cord-296347-fanlvxqs	950	2	2004	2004	CD
cord-296347-fanlvxqs	950	3	;	;	:
cord-296347-fanlvxqs	950	4	Hiscott	Hiscott	NNP
cord-296347-fanlvxqs	950	5	et	et	NNP
cord-296347-fanlvxqs	950	6	al	al	NNP
cord-296347-fanlvxqs	950	7	.	.	NNP
cord-296347-fanlvxqs	950	8	,	,	,
cord-296347-fanlvxqs	950	9	2001	2001	CD
cord-296347-fanlvxqs	950	10	;	;	:
cord-296347-fanlvxqs	950	11	Mason	Mason	NNP
cord-296347-fanlvxqs	950	12	et	et	NNP
cord-296347-fanlvxqs	950	13	al	al	NNP
cord-296347-fanlvxqs	950	14	.	.	NNP
cord-296347-fanlvxqs	950	15	,	,	,
cord-296347-fanlvxqs	950	16	2004	2004	CD
cord-296347-fanlvxqs	950	17	)	)	-RRB-
cord-296347-fanlvxqs	950	18	.	.	.
cord-296347-fanlvxqs	951	1	The	the	DT
cord-296347-fanlvxqs	951	2	human	human	JJ
cord-296347-fanlvxqs	951	3	enteric	enteric	JJ
cord-296347-fanlvxqs	951	4	flora	flora	NNS
cord-296347-fanlvxqs	951	5	may	may	MD
cord-296347-fanlvxqs	951	6	influence	influence	VB
cord-296347-fanlvxqs	951	7	intestinal	intestinal	JJ
cord-296347-fanlvxqs	951	8	epithelium	epithelium	NN
cord-296347-fanlvxqs	951	9	inflammatory	inflammatory	JJ
cord-296347-fanlvxqs	951	10	tolerance	tolerance	NN
cord-296347-fanlvxqs	951	11	by	by	IN
cord-296347-fanlvxqs	951	12	inhibiting	inhibit	VBG
cord-296347-fanlvxqs	951	13	the	the	DT
cord-296347-fanlvxqs	951	14	NF	NF	NNP
cord-296347-fanlvxqs	951	15	-	-	HYPH
cord-296347-fanlvxqs	951	16	kB	kB	NNP
cord-296347-fanlvxqs	951	17	pathway	pathway	NN
cord-296347-fanlvxqs	951	18	,	,	,
cord-296347-fanlvxqs	951	19	which	which	WDT
cord-296347-fanlvxqs	951	20	can	can	MD
cord-296347-fanlvxqs	951	21	be	be	VB
cord-296347-fanlvxqs	951	22	achieved	achieve	VBN
cord-296347-fanlvxqs	951	23	by	by	IN
cord-296347-fanlvxqs	951	24	blocking	block	VBG
cord-296347-fanlvxqs	951	25	any	any	DT
cord-296347-fanlvxqs	951	26	one	one	CD
cord-296347-fanlvxqs	951	27	of	of	IN
cord-296347-fanlvxqs	951	28	the	the	DT
cord-296347-fanlvxqs	951	29	many	many	JJ
cord-296347-fanlvxqs	951	30	Ub	ub	JJ
cord-296347-fanlvxqs	951	31	-	-	HYPH
cord-296347-fanlvxqs	951	32	dependent	dependent	JJ
cord-296347-fanlvxqs	951	33	steps	step	NNS
cord-296347-fanlvxqs	951	34	that	that	WDT
cord-296347-fanlvxqs	951	35	control	control	VBP
cord-296347-fanlvxqs	951	36	it	-PRON-	PRP
cord-296347-fanlvxqs	951	37	.	.	.
cord-296347-fanlvxqs	952	1	Shigella	Shigella	NNP
cord-296347-fanlvxqs	952	2	flexneri	flexneri	NN
cord-296347-fanlvxqs	952	3	,	,	,
cord-296347-fanlvxqs	952	4	which	which	WDT
cord-296347-fanlvxqs	952	5	causes	cause	VBZ
cord-296347-fanlvxqs	952	6	severe	severe	JJ
cord-296347-fanlvxqs	952	7	diarrhea	diarrhea	NN
cord-296347-fanlvxqs	952	8	in	in	IN
cord-296347-fanlvxqs	952	9	humans	human	NNS
cord-296347-fanlvxqs	952	10	,	,	,
cord-296347-fanlvxqs	952	11	injects	inject	VBZ
cord-296347-fanlvxqs	952	12	TTSS	TTSS	NNP
cord-296347-fanlvxqs	952	13	-	-	HYPH
cord-296347-fanlvxqs	952	14	effector	effector	NN
cord-296347-fanlvxqs	952	15	proteins	protein	NNS
cord-296347-fanlvxqs	952	16	into	into	IN
cord-296347-fanlvxqs	952	17	host	host	NN
cord-296347-fanlvxqs	952	18	cells	cell	NNS
cord-296347-fanlvxqs	952	19	to	to	TO
cord-296347-fanlvxqs	952	20	induce	induce	VB
cord-296347-fanlvxqs	952	21	their	-PRON-	PRP$
cord-296347-fanlvxqs	952	22	entry	entry	NN
cord-296347-fanlvxqs	952	23	into	into	IN
cord-296347-fanlvxqs	952	24	epithelial	epithelial	JJ
cord-296347-fanlvxqs	952	25	cells	cell	NNS
cord-296347-fanlvxqs	952	26	or	or	CC
cord-296347-fanlvxqs	952	27	trigger	trigger	NN
cord-296347-fanlvxqs	952	28	apoptosis	apoptosis	NN
cord-296347-fanlvxqs	952	29	in	in	IN
cord-296347-fanlvxqs	952	30	macrophages	macrophage	NNS
cord-296347-fanlvxqs	952	31	.	.	.
cord-296347-fanlvxqs	953	1	The	the	DT
cord-296347-fanlvxqs	953	2	OspG	OspG	NNP
cord-296347-fanlvxqs	953	3	effector	effector	NN
cord-296347-fanlvxqs	953	4	is	be	VBZ
cord-296347-fanlvxqs	953	5	a	a	DT
cord-296347-fanlvxqs	953	6	serine/	serine/	CD
cord-296347-fanlvxqs	953	7	threonine	threonine	NN
cord-296347-fanlvxqs	953	8	kinase	kinase	NN
cord-296347-fanlvxqs	953	9	that	that	WDT
cord-296347-fanlvxqs	953	10	binds	bind	VBZ
cord-296347-fanlvxqs	953	11	various	various	JJ
cord-296347-fanlvxqs	953	12	E2s	E2s	NNP
cord-296347-fanlvxqs	953	13	,	,	,
cord-296347-fanlvxqs	953	14	including	include	VBG
cord-296347-fanlvxqs	953	15	UbcH5	UbcH5	NNP
cord-296347-fanlvxqs	953	16	,	,	,
cord-296347-fanlvxqs	953	17	a	a	DT
cord-296347-fanlvxqs	953	18	component	component	NN
cord-296347-fanlvxqs	953	19	of	of	IN
cord-296347-fanlvxqs	953	20	the	the	DT
cord-296347-fanlvxqs	953	21	SCF	SCF	NNP
cord-296347-fanlvxqs	953	22	b	b	NNP
cord-296347-fanlvxqs	953	23	-	-	:
cord-296347-fanlvxqs	953	24	TrCP	TrCP	NNP
cord-296347-fanlvxqs	953	25	E3	E3	NNP
cord-296347-fanlvxqs	953	26	complex	complex	NN
cord-296347-fanlvxqs	953	27	.	.	.
cord-296347-fanlvxqs	954	1	OspG	OspG	NNP
cord-296347-fanlvxqs	954	2	binding	bind	VBG
cord-296347-fanlvxqs	954	3	to	to	IN
cord-296347-fanlvxqs	954	4	UbcH5	UbcH5	NNP
cord-296347-fanlvxqs	954	5	inhibits	inhibit	VBZ
cord-296347-fanlvxqs	954	6	the	the	DT
cord-296347-fanlvxqs	954	7	SCF	SCF	NNP
cord-296347-fanlvxqs	954	8	b	b	NN
cord-296347-fanlvxqs	954	9	-	-	:
cord-296347-fanlvxqs	954	10	TrCP	trcp	NN
cord-296347-fanlvxqs	954	11	complex	complex	NN
cord-296347-fanlvxqs	954	12	and	and	CC
cord-296347-fanlvxqs	954	13	thereby	thereby	RB
cord-296347-fanlvxqs	954	14	phospho	phospho	NN
cord-296347-fanlvxqs	954	15	-	-	HYPH
cord-296347-fanlvxqs	954	16	IkB	ikb	NN
cord-296347-fanlvxqs	954	17	degradation	degradation	NN
cord-296347-fanlvxqs	954	18	,	,	,
cord-296347-fanlvxqs	954	19	blocking	block	VBG
cord-296347-fanlvxqs	954	20	NF	nf	NN
cord-296347-fanlvxqs	954	21	-	-	HYPH
cord-296347-fanlvxqs	954	22	kB	kB	NNP
cord-296347-fanlvxqs	955	1	signaling	signal	VBG
cord-296347-fanlvxqs	955	2	in	in	IN
cord-296347-fanlvxqs	955	3	response	response	NN
cord-296347-fanlvxqs	955	4	to	to	IN
cord-296347-fanlvxqs	955	5	the	the	DT
cord-296347-fanlvxqs	955	6	bacterial	bacterial	JJ
cord-296347-fanlvxqs	955	7	infection	infection	NN
cord-296347-fanlvxqs	955	8	.	.	.
cord-296347-fanlvxqs	956	1	The	the	DT
cord-296347-fanlvxqs	956	2	Cullin	Cullin	NNP
cord-296347-fanlvxqs	956	3	subunit	subunit	NN
cord-296347-fanlvxqs	956	4	of	of	IN
cord-296347-fanlvxqs	956	5	the	the	DT
cord-296347-fanlvxqs	956	6	SCF	SCF	NNP
cord-296347-fanlvxqs	956	7	b	b	NNP
cord-296347-fanlvxqs	956	8	-	-	:
cord-296347-fanlvxqs	956	9	TrCP	trcp	NN
cord-296347-fanlvxqs	956	10	complex	complex	NN
cord-296347-fanlvxqs	956	11	is	be	VBZ
cord-296347-fanlvxqs	956	12	itself	-PRON-	PRP
cord-296347-fanlvxqs	956	13	regulated	regulate	VBN
cord-296347-fanlvxqs	956	14	by	by	IN
cord-296347-fanlvxqs	956	15	NEDD8	NEDD8	NNP
cord-296347-fanlvxqs	956	16	attachment	attachment	NN
cord-296347-fanlvxqs	956	17	(	(	-LRB-
cord-296347-fanlvxqs	956	18	Pan	Pan	NNP
cord-296347-fanlvxqs	956	19	et	et	FW
cord-296347-fanlvxqs	956	20	al	al	NNP
cord-296347-fanlvxqs	956	21	.	.	NNP
cord-296347-fanlvxqs	956	22	,	,	,
cord-296347-fanlvxqs	956	23	2004	2004	CD
cord-296347-fanlvxqs	956	24	)	)	-RRB-
cord-296347-fanlvxqs	956	25	.	.	.
cord-296347-fanlvxqs	957	1	Certain	certain	JJ
cord-296347-fanlvxqs	957	2	enteric	enteric	JJ
cord-296347-fanlvxqs	957	3	bacteria	bacteria	NNS
cord-296347-fanlvxqs	957	4	can	can	MD
cord-296347-fanlvxqs	957	5	lead	lead	VB
cord-296347-fanlvxqs	957	6	to	to	IN
cord-296347-fanlvxqs	957	7	rapid	rapid	JJ
cord-296347-fanlvxqs	957	8	deneddylation	deneddylation	NN
cord-296347-fanlvxqs	957	9	of	of	IN
cord-296347-fanlvxqs	957	10	Cullin-1	Cullin-1	NNP
cord-296347-fanlvxqs	957	11	and	and	CC
cord-296347-fanlvxqs	957	12	consequent	consequent	JJ
cord-296347-fanlvxqs	957	13	repression	repression	NN
cord-296347-fanlvxqs	957	14	of	of	IN
cord-296347-fanlvxqs	957	15	the	the	DT
cord-296347-fanlvxqs	957	16	NF	NF	NNP
cord-296347-fanlvxqs	957	17	-	-	HYPH
cord-296347-fanlvxqs	957	18	kB	kB	NNP
cord-296347-fanlvxqs	957	19	pathway	pathway	NN
cord-296347-fanlvxqs	957	20	(	(	-LRB-
cord-296347-fanlvxqs	957	21	Collier	Collier	NNP
cord-296347-fanlvxqs	957	22	-	-	HYPH
cord-296347-fanlvxqs	957	23	Hyams	Hyams	NNP
cord-296347-fanlvxqs	957	24	et	et	NNP
cord-296347-fanlvxqs	957	25	al	al	NNP
cord-296347-fanlvxqs	957	26	.	.	NNP
cord-296347-fanlvxqs	957	27	,	,	,
cord-296347-fanlvxqs	957	28	2005	2005	CD
cord-296347-fanlvxqs	957	29	)	)	-RRB-
cord-296347-fanlvxqs	957	30	,	,	,
cord-296347-fanlvxqs	957	31	but	but	CC
cord-296347-fanlvxqs	957	32	the	the	DT
cord-296347-fanlvxqs	957	33	bacterial	bacterial	JJ
cord-296347-fanlvxqs	957	34	activities	activity	NNS
cord-296347-fanlvxqs	957	35	responsible	responsible	JJ
cord-296347-fanlvxqs	957	36	are	be	VBP
cord-296347-fanlvxqs	957	37	still	still	RB
cord-296347-fanlvxqs	957	38	to	to	TO
cord-296347-fanlvxqs	957	39	be	be	VB
cord-296347-fanlvxqs	957	40	determined	determine	VBN
cord-296347-fanlvxqs	957	41	.	.	.
cord-296347-fanlvxqs	958	1	In	in	IN
cord-296347-fanlvxqs	958	2	any	any	DT
cord-296347-fanlvxqs	958	3	case	case	NN
cord-296347-fanlvxqs	958	4	,	,	,
cord-296347-fanlvxqs	958	5	because	because	IN
cord-296347-fanlvxqs	958	6	NF	NF	NNP
cord-296347-fanlvxqs	958	7	-	-	HYPH
cord-296347-fanlvxqs	958	8	kB	kB	NNP
cord-296347-fanlvxqs	958	9	is	be	VBZ
cord-296347-fanlvxqs	958	10	crucial	crucial	JJ
cord-296347-fanlvxqs	958	11	for	for	IN
cord-296347-fanlvxqs	958	12	both	both	CC
cord-296347-fanlvxqs	958	13	the	the	DT
cord-296347-fanlvxqs	958	14	initial	initial	JJ
cord-296347-fanlvxqs	958	15	innate	innate	JJ
cord-296347-fanlvxqs	958	16	inflammatory	inflammatory	JJ
cord-296347-fanlvxqs	958	17	response	response	NN
cord-296347-fanlvxqs	958	18	and	and	CC
cord-296347-fanlvxqs	958	19	for	for	IN
cord-296347-fanlvxqs	958	20	coordination	coordination	NN
cord-296347-fanlvxqs	958	21	of	of	IN
cord-296347-fanlvxqs	958	22	the	the	DT
cord-296347-fanlvxqs	958	23	adaptive	adaptive	JJ
cord-296347-fanlvxqs	958	24	immune	immune	JJ
cord-296347-fanlvxqs	958	25	response	response	NN
cord-296347-fanlvxqs	958	26	,	,	,
cord-296347-fanlvxqs	958	27	dampening	dampening	NN
cord-296347-fanlvxqs	958	28	of	of	IN
cord-296347-fanlvxqs	958	29	inflammation	inflammation	NN
cord-296347-fanlvxqs	958	30	may	may	MD
cord-296347-fanlvxqs	958	31	endow	endow	VB
cord-296347-fanlvxqs	958	32	Shigella	Shigella	NNP
cord-296347-fanlvxqs	958	33	and	and	CC
cord-296347-fanlvxqs	958	34	other	other	JJ
cord-296347-fanlvxqs	958	35	enteric	enteric	JJ
cord-296347-fanlvxqs	958	36	bacteria	bacteria	NNS
cord-296347-fanlvxqs	958	37	with	with	IN
cord-296347-fanlvxqs	958	38	the	the	DT
cord-296347-fanlvxqs	958	39	ability	ability	NN
cord-296347-fanlvxqs	958	40	to	to	TO
cord-296347-fanlvxqs	958	41	invade	invade	VB
cord-296347-fanlvxqs	958	42	and	and	CC
cord-296347-fanlvxqs	958	43	later	later	RB
cord-296347-fanlvxqs	958	44	colonize	colonize	VB
cord-296347-fanlvxqs	958	45	the	the	DT
cord-296347-fanlvxqs	958	46	gastrointestinal	gastrointestinal	JJ
cord-296347-fanlvxqs	958	47	epithelium	epithelium	NN
cord-296347-fanlvxqs	958	48	(	(	-LRB-
cord-296347-fanlvxqs	958	49	Kim	Kim	NNP
cord-296347-fanlvxqs	958	50	et	et	NNP
cord-296347-fanlvxqs	958	51	al	al	NNP
cord-296347-fanlvxqs	958	52	.	.	NNP
cord-296347-fanlvxqs	958	53	,	,	,
cord-296347-fanlvxqs	958	54	2005	2005	CD
cord-296347-fanlvxqs	958	55	)	)	-RRB-
cord-296347-fanlvxqs	958	56	.	.	.
cord-296347-fanlvxqs	959	1	RNA	RNA	NNP
cord-296347-fanlvxqs	959	2	interference	interference	NN
cord-296347-fanlvxqs	959	3	(	(	-LRB-
cord-296347-fanlvxqs	959	4	or	or	CC
cord-296347-fanlvxqs	959	5	posttranscriptional	posttranscriptional	JJ
cord-296347-fanlvxqs	959	6	gene	gene	NN
cord-296347-fanlvxqs	959	7	silencing	silence	VBG
cord-296347-fanlvxqs	959	8	)	)	-RRB-
cord-296347-fanlvxqs	959	9	in	in	IN
cord-296347-fanlvxqs	959	10	plants	plant	NNS
cord-296347-fanlvxqs	959	11	and	and	CC
cord-296347-fanlvxqs	959	12	invertebrate	invertebrate	JJ
cord-296347-fanlvxqs	959	13	animals	animal	NNS
cord-296347-fanlvxqs	959	14	is	be	VBZ
cord-296347-fanlvxqs	959	15	important	important	JJ
cord-296347-fanlvxqs	959	16	for	for	IN
cord-296347-fanlvxqs	959	17	many	many	JJ
cord-296347-fanlvxqs	959	18	regulatory	regulatory	JJ
cord-296347-fanlvxqs	959	19	processes	process	NNS
cord-296347-fanlvxqs	959	20	and	and	CC
cord-296347-fanlvxqs	959	21	a	a	DT
cord-296347-fanlvxqs	959	22	primitive	primitive	JJ
cord-296347-fanlvxqs	959	23	form	form	NN
cord-296347-fanlvxqs	959	24	of	of	IN
cord-296347-fanlvxqs	959	25	antiviral	antiviral	JJ
cord-296347-fanlvxqs	959	26	immunity	immunity	NN
cord-296347-fanlvxqs	959	27	that	that	WDT
cord-296347-fanlvxqs	959	28	is	be	VBZ
cord-296347-fanlvxqs	959	29	nucleic	nucleic	JJ
cord-296347-fanlvxqs	959	30	acid	acid	NN
cord-296347-fanlvxqs	959	31	based	base	VBN
cord-296347-fanlvxqs	959	32	.	.	.
cord-296347-fanlvxqs	960	1	Consequently	consequently	RB
cord-296347-fanlvxqs	960	2	,	,	,
cord-296347-fanlvxqs	960	3	plant	plant	NN
cord-296347-fanlvxqs	960	4	viruses	virus	NNS
cord-296347-fanlvxqs	960	5	have	have	VBP
cord-296347-fanlvxqs	960	6	evolved	evolve	VBN
cord-296347-fanlvxqs	960	7	proteins	protein	NNS
cord-296347-fanlvxqs	960	8	,	,	,
cord-296347-fanlvxqs	960	9	the	the	DT
cord-296347-fanlvxqs	960	10	so	so	RB
cord-296347-fanlvxqs	960	11	-	-	HYPH
cord-296347-fanlvxqs	960	12	called	call	VBN
cord-296347-fanlvxqs	960	13	silencing	silence	VBG
cord-296347-fanlvxqs	960	14	suppressors	suppressor	NNS
cord-296347-fanlvxqs	960	15	,	,	,
cord-296347-fanlvxqs	960	16	which	which	WDT
cord-296347-fanlvxqs	960	17	directly	directly	RB
cord-296347-fanlvxqs	960	18	bind	bind	VBP
cord-296347-fanlvxqs	960	19	to	to	IN
cord-296347-fanlvxqs	960	20	and	and	CC
cord-296347-fanlvxqs	960	21	inactivate	inactivate	VB
cord-296347-fanlvxqs	960	22	the	the	DT
cord-296347-fanlvxqs	960	23	plant	plant	NN
cord-296347-fanlvxqs	960	24	microRNAs	microrna	NNS
cord-296347-fanlvxqs	961	1	(	(	-LRB-
cord-296347-fanlvxqs	961	2	Ding	Ding	NNP
cord-296347-fanlvxqs	961	3	et	et	FW
cord-296347-fanlvxqs	961	4	al	al	NNP
cord-296347-fanlvxqs	961	5	.	.	NNP
cord-296347-fanlvxqs	961	6	,	,	,
cord-296347-fanlvxqs	961	7	2004	2004	CD
cord-296347-fanlvxqs	961	8	;	;	:
cord-296347-fanlvxqs	961	9	Zamore	Zamore	NNP
cord-296347-fanlvxqs	961	10	,	,	,
cord-296347-fanlvxqs	961	11	2004	2004	CD
cord-296347-fanlvxqs	961	12	)	)	-RRB-
cord-296347-fanlvxqs	961	13	.	.	.
cord-296347-fanlvxqs	962	1	Poleroviruses	poleroviruse	NNS
cord-296347-fanlvxqs	962	2	are	be	VBP
cord-296347-fanlvxqs	962	3	small	small	JJ
cord-296347-fanlvxqs	962	4	positive	positive	JJ
cord-296347-fanlvxqs	962	5	-	-	HYPH
cord-296347-fanlvxqs	962	6	strand	strand	NN
cord-296347-fanlvxqs	962	7	RNA	RNA	NNP
cord-296347-fanlvxqs	962	8	viruses	virus	NNS
cord-296347-fanlvxqs	962	9	that	that	WDT
cord-296347-fanlvxqs	962	10	cause	cause	VBP
cord-296347-fanlvxqs	962	11	leafroll	leafroll	NN
cord-296347-fanlvxqs	962	12	phenotypes	phenotype	NNS
cord-296347-fanlvxqs	962	13	in	in	IN
cord-296347-fanlvxqs	962	14	many	many	JJ
cord-296347-fanlvxqs	962	15	plant	plant	NN
cord-296347-fanlvxqs	962	16	species	specie	NNS
cord-296347-fanlvxqs	962	17	.	.	.
cord-296347-fanlvxqs	963	1	Poleroviruses	poleroviruse	NNS
cord-296347-fanlvxqs	963	2	encode	encode	VBP
cord-296347-fanlvxqs	963	3	a	a	DT
cord-296347-fanlvxqs	963	4	silencing	silence	VBG
cord-296347-fanlvxqs	963	5	suppressor	suppressor	NN
cord-296347-fanlvxqs	963	6	P0	p0	NN
cord-296347-fanlvxqs	963	7	,	,	,
cord-296347-fanlvxqs	963	8	which	which	WDT
cord-296347-fanlvxqs	963	9	is	be	VBZ
cord-296347-fanlvxqs	963	10	a	a	DT
cord-296347-fanlvxqs	963	11	viral	viral	JJ
cord-296347-fanlvxqs	963	12	F	F	NNP
cord-296347-fanlvxqs	963	13	-	-	HYPH
cord-296347-fanlvxqs	963	14	box	box	NN
cord-296347-fanlvxqs	963	15	protein	protein	NN
cord-296347-fanlvxqs	963	16	(	(	-LRB-
cord-296347-fanlvxqs	963	17	Barry	Barry	NNP
cord-296347-fanlvxqs	963	18	and	and	CC
cord-296347-fanlvxqs	963	19	Fruh	Fruh	NNP
cord-296347-fanlvxqs	963	20	,	,	,
cord-296347-fanlvxqs	963	21	2006	2006	CD
cord-296347-fanlvxqs	963	22	)	)	-RRB-
cord-296347-fanlvxqs	963	23	.	.	.
cord-296347-fanlvxqs	964	1	P0	p0	NN
cord-296347-fanlvxqs	964	2	has	have	VBZ
cord-296347-fanlvxqs	964	3	a	a	DT
cord-296347-fanlvxqs	964	4	minimal	minimal	JJ
cord-296347-fanlvxqs	964	5	conserved	conserved	JJ
cord-296347-fanlvxqs	964	6	F	F	NNP
cord-296347-fanlvxqs	964	7	-	-	HYPH
cord-296347-fanlvxqs	964	8	box	box	NN
cord-296347-fanlvxqs	964	9	motif	motif	NN
cord-296347-fanlvxqs	964	10	that	that	WDT
cord-296347-fanlvxqs	964	11	can	can	MD
cord-296347-fanlvxqs	964	12	bind	bind	VB
cord-296347-fanlvxqs	964	13	the	the	DT
cord-296347-fanlvxqs	964	14	plant	plant	NN
cord-296347-fanlvxqs	964	15	Skp-1	Skp-1	NNP
cord-296347-fanlvxqs	964	16	homologue	homologue	NN
cord-296347-fanlvxqs	964	17	and	and	CC
cord-296347-fanlvxqs	964	18	form	form	VB
cord-296347-fanlvxqs	964	19	a	a	DT
cord-296347-fanlvxqs	964	20	functional	functional	JJ
cord-296347-fanlvxqs	964	21	complex	complex	NN
cord-296347-fanlvxqs	964	22	with	with	IN
cord-296347-fanlvxqs	964	23	the	the	DT
cord-296347-fanlvxqs	964	24	plant	plant	NN
cord-296347-fanlvxqs	964	25	Cullin-1	Cullin-1	NNP
cord-296347-fanlvxqs	964	26	homologue	homologue	NN
cord-296347-fanlvxqs	964	27	.	.	.
cord-296347-fanlvxqs	965	1	The	the	DT
cord-296347-fanlvxqs	965	2	P0	P0	NNP
cord-296347-fanlvxqs	965	3	F	F	NNP
cord-296347-fanlvxqs	965	4	-	-	HYPH
cord-296347-fanlvxqs	965	5	box	box	NNP
cord-296347-fanlvxqs	965	6	is	be	VBZ
cord-296347-fanlvxqs	965	7	required	require	VBN
cord-296347-fanlvxqs	965	8	for	for	IN
cord-296347-fanlvxqs	965	9	polerovirus	polerovirus	NNP
cord-296347-fanlvxqs	965	10	infectivity	infectivity	NN
cord-296347-fanlvxqs	965	11	and	and	CC
cord-296347-fanlvxqs	965	12	its	-PRON-	PRP$
cord-296347-fanlvxqs	965	13	silencing	silence	VBG
cord-296347-fanlvxqs	965	14	suppressor	suppressor	NN
cord-296347-fanlvxqs	965	15	function	function	NN
cord-296347-fanlvxqs	966	1	(	(	-LRB-
cord-296347-fanlvxqs	966	2	Pazhouhandeh	Pazhouhandeh	NNP
cord-296347-fanlvxqs	966	3	et	et	NNP
cord-296347-fanlvxqs	966	4	al	al	NNP
cord-296347-fanlvxqs	966	5	.	.	NNP
cord-296347-fanlvxqs	966	6	,	,	,
cord-296347-fanlvxqs	966	7	2006	2006	CD
cord-296347-fanlvxqs	966	8	)	)	-RRB-
cord-296347-fanlvxqs	966	9	.	.	.
cord-296347-fanlvxqs	967	1	P0	p0	NN
cord-296347-fanlvxqs	967	2	presumably	presumably	RB
cord-296347-fanlvxqs	967	3	binds	bind	VBZ
cord-296347-fanlvxqs	967	4	the	the	DT
cord-296347-fanlvxqs	967	5	microRNAs	microRNAs	NNPS
cord-296347-fanlvxqs	967	6	and	and	CC
cord-296347-fanlvxqs	967	7	targets	target	VBZ
cord-296347-fanlvxqs	967	8	them	-PRON-	PRP
cord-296347-fanlvxqs	967	9	for	for	IN
cord-296347-fanlvxqs	967	10	Cullin-4A	Cullin-4A	NNP
cord-296347-fanlvxqs	967	11	-	-	HYPH
cord-296347-fanlvxqs	967	12	dependent	dependent	JJ
cord-296347-fanlvxqs	967	13	degradation	degradation	NN
cord-296347-fanlvxqs	967	14	.	.	.
cord-296347-fanlvxqs	968	1	This	this	DT
cord-296347-fanlvxqs	968	2	constitutes	constitute	VBZ
cord-296347-fanlvxqs	968	3	a	a	DT
cord-296347-fanlvxqs	968	4	remarkable	remarkable	JJ
cord-296347-fanlvxqs	968	5	finding	finding	NN
cord-296347-fanlvxqs	968	6	,	,	,
cord-296347-fanlvxqs	968	7	as	as	IN
cord-296347-fanlvxqs	968	8	degradation	degradation	NN
cord-296347-fanlvxqs	968	9	of	of	IN
cord-296347-fanlvxqs	968	10	RNA	RNA	NNP
cord-296347-fanlvxqs	968	11	(	(	-LRB-
cord-296347-fanlvxqs	968	12	and	and	CC
cord-296347-fanlvxqs	968	13	not	not	RB
cord-296347-fanlvxqs	968	14	protein	protein	NN
cord-296347-fanlvxqs	968	15	)	)	-RRB-
cord-296347-fanlvxqs	968	16	by	by	IN
cord-296347-fanlvxqs	968	17	an	an	DT
cord-296347-fanlvxqs	968	18	E3	e3	NN
cord-296347-fanlvxqs	968	19	ligase	ligase	NN
cord-296347-fanlvxqs	968	20	had	have	VBD
cord-296347-fanlvxqs	968	21	not	not	RB
cord-296347-fanlvxqs	968	22	been	be	VBN
cord-296347-fanlvxqs	968	23	documented	document	VBN
cord-296347-fanlvxqs	968	24	before	before	RB
cord-296347-fanlvxqs	968	25	.	.	.
cord-296347-fanlvxqs	969	1	This	this	DT
cord-296347-fanlvxqs	969	2	primitive	primitive	JJ
cord-296347-fanlvxqs	969	3	form	form	NN
cord-296347-fanlvxqs	969	4	of	of	IN
cord-296347-fanlvxqs	969	5	antiviral	antiviral	JJ
cord-296347-fanlvxqs	969	6	immunity	immunity	NN
cord-296347-fanlvxqs	969	7	,	,	,
cord-296347-fanlvxqs	969	8	although	although	IN
cord-296347-fanlvxqs	969	9	widely	widely	RB
cord-296347-fanlvxqs	969	10	used	use	VBN
cord-296347-fanlvxqs	969	11	as	as	IN
cord-296347-fanlvxqs	969	12	a	a	DT
cord-296347-fanlvxqs	969	13	laboratory	laboratory	NN
cord-296347-fanlvxqs	969	14	tool	tool	NN
cord-296347-fanlvxqs	969	15	was	be	VBD
cord-296347-fanlvxqs	969	16	only	only	RB
cord-296347-fanlvxqs	969	17	recently	recently	RB
cord-296347-fanlvxqs	969	18	shown	show	VBN
cord-296347-fanlvxqs	969	19	to	to	TO
cord-296347-fanlvxqs	969	20	occur	occur	VB
cord-296347-fanlvxqs	969	21	in	in	IN
cord-296347-fanlvxqs	969	22	the	the	DT
cord-296347-fanlvxqs	969	23	context	context	NN
cord-296347-fanlvxqs	969	24	of	of	IN
cord-296347-fanlvxqs	969	25	a	a	DT
cord-296347-fanlvxqs	969	26	natural	natural	JJ
cord-296347-fanlvxqs	969	27	viral	viral	JJ
cord-296347-fanlvxqs	969	28	infection	infection	NN
cord-296347-fanlvxqs	969	29	in	in	IN
cord-296347-fanlvxqs	969	30	jawed	jawed	JJ
cord-296347-fanlvxqs	969	31	vertebrates	vertebrate	NNS
cord-296347-fanlvxqs	970	1	(	(	-LRB-
cord-296347-fanlvxqs	970	2	Browne	Browne	NNP
cord-296347-fanlvxqs	970	3	et	et	NNP
cord-296347-fanlvxqs	970	4	al	al	NNP
cord-296347-fanlvxqs	970	5	.	.	NNP
cord-296347-fanlvxqs	970	6	,	,	,
cord-296347-fanlvxqs	970	7	2005	2005	CD
cord-296347-fanlvxqs	970	8	)	)	-RRB-
cord-296347-fanlvxqs	970	9	.	.	.
cord-296347-fanlvxqs	971	1	HIV-1	HIV-1	NNP
cord-296347-fanlvxqs	971	2	encodes	encode	VBZ
cord-296347-fanlvxqs	971	3	viral	viral	JJ
cord-296347-fanlvxqs	971	4	small	small	JJ
cord-296347-fanlvxqs	971	5	interfering	interfere	VBG
cord-296347-fanlvxqs	971	6	RNA	RNA	NNP
cord-296347-fanlvxqs	971	7	(	(	-LRB-
cord-296347-fanlvxqs	971	8	siRNA	siRNA	NNP
cord-296347-fanlvxqs	971	9	)	)	-RRB-
cord-296347-fanlvxqs	971	10	precursors	precursor	NNS
cord-296347-fanlvxqs	971	11	that	that	WDT
cord-296347-fanlvxqs	971	12	provoke	provoke	VBP
cord-296347-fanlvxqs	971	13	RNA	RNA	NNP
cord-296347-fanlvxqs	971	14	silencing	silencing	NN
cord-296347-fanlvxqs	971	15	in	in	IN
cord-296347-fanlvxqs	971	16	human	human	JJ
cord-296347-fanlvxqs	971	17	cells	cell	NNS
cord-296347-fanlvxqs	971	18	,	,	,
cord-296347-fanlvxqs	971	19	so	so	RB
cord-296347-fanlvxqs	971	20	not	not	RB
cord-296347-fanlvxqs	971	21	surprisingly	surprisingly	RB
cord-296347-fanlvxqs	971	22	,	,	,
cord-296347-fanlvxqs	971	23	the	the	DT
cord-296347-fanlvxqs	971	24	HIV-1	HIV-1	NNP
cord-296347-fanlvxqs	971	25	Tat	Tat	NNP
cord-296347-fanlvxqs	971	26	protein	protein	NN
cord-296347-fanlvxqs	971	27	also	also	RB
cord-296347-fanlvxqs	971	28	contains	contain	VBZ
cord-296347-fanlvxqs	971	29	a	a	DT
cord-296347-fanlvxqs	971	30	silencing	silence	VBG
cord-296347-fanlvxqs	971	31	suppressor	suppressor	NN
cord-296347-fanlvxqs	971	32	function	function	NN
cord-296347-fanlvxqs	971	33	(	(	-LRB-
cord-296347-fanlvxqs	971	34	Bennasser	Bennasser	NNP
cord-296347-fanlvxqs	971	35	et	et	NNP
cord-296347-fanlvxqs	971	36	al	al	NNP
cord-296347-fanlvxqs	971	37	.	.	NNP
cord-296347-fanlvxqs	971	38	,	,	,
cord-296347-fanlvxqs	971	39	2005	2005	CD
cord-296347-fanlvxqs	971	40	)	)	-RRB-
cord-296347-fanlvxqs	971	41	,	,	,
cord-296347-fanlvxqs	971	42	that	that	WDT
cord-296347-fanlvxqs	971	43	prevents	prevent	VBZ
cord-296347-fanlvxqs	971	44	Dicer	Dicer	NNP
cord-296347-fanlvxqs	971	45	from	from	IN
cord-296347-fanlvxqs	971	46	processing	process	VBG
cord-296347-fanlvxqs	971	47	the	the	DT
cord-296347-fanlvxqs	971	48	precursor	precursor	NN
cord-296347-fanlvxqs	971	49	double	double	RB
cord-296347-fanlvxqs	971	50	-	-	HYPH
cord-296347-fanlvxqs	971	51	stranded	stranded	JJ
cord-296347-fanlvxqs	971	52	RNAs	rna	NNS
cord-296347-fanlvxqs	971	53	into	into	IN
cord-296347-fanlvxqs	971	54	siRNAs	siRNAs	NNP
cord-296347-fanlvxqs	971	55	.	.	.
cord-296347-fanlvxqs	972	1	Suppression	Suppression	NNP
cord-296347-fanlvxqs	972	2	of	of	IN
cord-296347-fanlvxqs	972	3	RNA	RNA	NNP
cord-296347-fanlvxqs	972	4	silencing	silence	VBG
cord-296347-fanlvxqs	972	5	by	by	IN
cord-296347-fanlvxqs	972	6	other	other	JJ
cord-296347-fanlvxqs	972	7	RNA	RNA	NNP
cord-296347-fanlvxqs	972	8	viruses	virus	NNS
cord-296347-fanlvxqs	972	9	is	be	VBZ
cord-296347-fanlvxqs	972	10	likely	likely	JJ
cord-296347-fanlvxqs	972	11	to	to	TO
cord-296347-fanlvxqs	972	12	occur	occur	VB
cord-296347-fanlvxqs	972	13	.	.	.
cord-296347-fanlvxqs	973	1	It	-PRON-	PRP
cord-296347-fanlvxqs	973	2	will	will	MD
cord-296347-fanlvxqs	973	3	be	be	VB
cord-296347-fanlvxqs	973	4	interesting	interesting	JJ
cord-296347-fanlvxqs	973	5	to	to	TO
cord-296347-fanlvxqs	973	6	see	see	VB
cord-296347-fanlvxqs	973	7	whether	whether	IN
cord-296347-fanlvxqs	973	8	the	the	DT
cord-296347-fanlvxqs	973	9	mechanism	mechanism	NN
cord-296347-fanlvxqs	973	10	used	use	VBN
cord-296347-fanlvxqs	973	11	by	by	IN
cord-296347-fanlvxqs	973	12	the	the	DT
cord-296347-fanlvxqs	973	13	plant	plant	NN
cord-296347-fanlvxqs	973	14	poleroviruses	poleroviruse	NNS
cord-296347-fanlvxqs	973	15	is	be	VBZ
cord-296347-fanlvxqs	973	16	conserved	conserve	VBN
cord-296347-fanlvxqs	973	17	and	and	CC
cord-296347-fanlvxqs	973	18	whether	whether	IN
cord-296347-fanlvxqs	973	19	manipulation	manipulation	NN
cord-296347-fanlvxqs	973	20	of	of	IN
cord-296347-fanlvxqs	973	21	the	the	DT
cord-296347-fanlvxqs	973	22	Ub	Ub	NNP
cord-296347-fanlvxqs	973	23	-	-	HYPH
cord-296347-fanlvxqs	973	24	proteasome	proteasome	VBN
cord-296347-fanlvxqs	973	25	system	system	NN
cord-296347-fanlvxqs	973	26	for	for	IN
cord-296347-fanlvxqs	973	27	suppressing	suppress	VBG
cord-296347-fanlvxqs	973	28	RNA	RNA	NNP
cord-296347-fanlvxqs	973	29	interference	interference	NN
cord-296347-fanlvxqs	973	30	is	be	VBZ
cord-296347-fanlvxqs	973	31	more	more	RBR
cord-296347-fanlvxqs	973	32	widely	widely	RB
cord-296347-fanlvxqs	973	33	used	use	VBN
cord-296347-fanlvxqs	973	34	by	by	IN
cord-296347-fanlvxqs	973	35	mammalian	mammalian	JJ
cord-296347-fanlvxqs	973	36	RNA	RNA	NNP
cord-296347-fanlvxqs	973	37	viruses	virus	NNS
cord-296347-fanlvxqs	973	38	.	.	.
cord-296347-fanlvxqs	974	1	As	as	IN
cord-296347-fanlvxqs	974	2	mentioned	mention	VBN
cord-296347-fanlvxqs	974	3	earlier	early	RBR
cord-296347-fanlvxqs	974	4	,	,	,
cord-296347-fanlvxqs	974	5	several	several	JJ
cord-296347-fanlvxqs	974	6	g	g	NN
cord-296347-fanlvxqs	974	7	-	-	HYPH
cord-296347-fanlvxqs	974	8	herpesviruses	herpesviruses	NNP
cord-296347-fanlvxqs	974	9	and	and	CC
cord-296347-fanlvxqs	974	10	poxviruses	poxvirus	NNS
cord-296347-fanlvxqs	974	11	encode	encode	VB
cord-296347-fanlvxqs	974	12	PHD/	phd/	NN
cord-296347-fanlvxqs	974	13	LAP	lap	NN
cord-296347-fanlvxqs	974	14	E3s	e3s	NN
cord-296347-fanlvxqs	974	15	,	,	,
cord-296347-fanlvxqs	974	16	the	the	DT
cord-296347-fanlvxqs	974	17	K3	K3	NNP
cord-296347-fanlvxqs	974	18	homologues	homologue	NNS
cord-296347-fanlvxqs	974	19	,	,	,
cord-296347-fanlvxqs	974	20	that	that	WDT
cord-296347-fanlvxqs	974	21	include	include	VBP
cord-296347-fanlvxqs	974	22	the	the	DT
cord-296347-fanlvxqs	974	23	Kaposi's	Kaposi's	NNP
cord-296347-fanlvxqs	974	24	-	-	HYPH
cord-296347-fanlvxqs	974	25	sarcoma	sarcoma	NN
cord-296347-fanlvxqs	974	26	-	-	HYPH
cord-296347-fanlvxqs	974	27	associated	associate	VBN
cord-296347-fanlvxqs	974	28	herpesvirus	herpesvirus	NN
cord-296347-fanlvxqs	974	29	(	(	-LRB-
cord-296347-fanlvxqs	974	30	KSHV	KSHV	NNP
cord-296347-fanlvxqs	974	31	)	)	-RRB-
cord-296347-fanlvxqs	974	32	kK3	kK3	NNS
cord-296347-fanlvxqs	974	33	and	and	CC
cord-296347-fanlvxqs	974	34	kK5	kk5	RB
cord-296347-fanlvxqs	974	35	(	(	-LRB-
cord-296347-fanlvxqs	974	36	also	also	RB
cord-296347-fanlvxqs	974	37	called	call	VBN
cord-296347-fanlvxqs	974	38	modulator	modulator	NN
cord-296347-fanlvxqs	974	39	of	of	IN
cord-296347-fanlvxqs	974	40	immune	immune	JJ
cord-296347-fanlvxqs	974	41	recognition	recognition	NN
cord-296347-fanlvxqs	974	42	MIR-1	MIR-1	NNP
cord-296347-fanlvxqs	974	43	and	and	CC
cord-296347-fanlvxqs	974	44	MIR-2	MIR-2	NNP
cord-296347-fanlvxqs	974	45	,	,	,
cord-296347-fanlvxqs	974	46	respectively	respectively	RB
cord-296347-fanlvxqs	974	47	)	)	-RRB-
cord-296347-fanlvxqs	974	48	,	,	,
cord-296347-fanlvxqs	974	49	the	the	DT
cord-296347-fanlvxqs	974	50	MHV-68	MHV-68	NNP
cord-296347-fanlvxqs	974	51	mK3	mk3	NN
cord-296347-fanlvxqs	974	52	,	,	,
cord-296347-fanlvxqs	974	53	and	and	CC
cord-296347-fanlvxqs	974	54	the	the	DT
cord-296347-fanlvxqs	974	55	rabbit	rabbit	NN
cord-296347-fanlvxqs	974	56	myxoma	myxoma	NNP
cord-296347-fanlvxqs	974	57	virus	virus	NN
cord-296347-fanlvxqs	974	58	M153R	M153R	NNP
cord-296347-fanlvxqs	974	59	(	(	-LRB-
cord-296347-fanlvxqs	974	60	Coscoy	Coscoy	NNP
cord-296347-fanlvxqs	974	61	and	and	CC
cord-296347-fanlvxqs	974	62	Ganem	Ganem	NNP
cord-296347-fanlvxqs	974	63	,	,	,
cord-296347-fanlvxqs	974	64	2003	2003	CD
cord-296347-fanlvxqs	974	65	)	)	-RRB-
cord-296347-fanlvxqs	974	66	.	.	.
cord-296347-fanlvxqs	975	1	We	-PRON-	PRP
cord-296347-fanlvxqs	975	2	discussed	discuss	VBD
cord-296347-fanlvxqs	975	3	mK3	mK3	NNP
cord-296347-fanlvxqs	975	4	which	which	WDT
cord-296347-fanlvxqs	975	5	catalyzes	catalyze	VBZ
cord-296347-fanlvxqs	975	6	ubiquitination	ubiquitination	NN
cord-296347-fanlvxqs	975	7	and	and	CC
cord-296347-fanlvxqs	975	8	proteasomal	proteasomal	JJ
cord-296347-fanlvxqs	975	9	degradation	degradation	NN
cord-296347-fanlvxqs	975	10	of	of	IN
cord-296347-fanlvxqs	975	11	nascent	nascent	JJ
cord-296347-fanlvxqs	975	12	murine	murine	JJ
cord-296347-fanlvxqs	975	13	class	class	NN
cord-296347-fanlvxqs	975	14	I	-PRON-	PRP
cord-296347-fanlvxqs	975	15	MHC	MHC	NNP
cord-296347-fanlvxqs	975	16	HCs	hc	NNS
cord-296347-fanlvxqs	975	17	after	after	IN
cord-296347-fanlvxqs	975	18	dislocation	dislocation	NN
cord-296347-fanlvxqs	975	19	from	from	IN
cord-296347-fanlvxqs	975	20	the	the	DT
cord-296347-fanlvxqs	975	21	ER	ER	NNP
cord-296347-fanlvxqs	975	22	membrane	membrane	NN
cord-296347-fanlvxqs	975	23	Wang	Wang	NNP
cord-296347-fanlvxqs	975	24	et	et	NNP
cord-296347-fanlvxqs	975	25	al	al	NNP
cord-296347-fanlvxqs	975	26	.	.	NNP
cord-296347-fanlvxqs	975	27	,	,	,
cord-296347-fanlvxqs	975	28	2005	2005	CD
cord-296347-fanlvxqs	975	29	)	)	-RRB-
cord-296347-fanlvxqs	975	30	.	.	.
cord-296347-fanlvxqs	976	1	KSHV	KSHV	NNP
cord-296347-fanlvxqs	976	2	kK3	kK3	NNS
cord-296347-fanlvxqs	976	3	and	and	CC
cord-296347-fanlvxqs	976	4	kK5	kk5	NN
cord-296347-fanlvxqs	976	5	and	and	CC
cord-296347-fanlvxqs	976	6	myxoma	myxoma	NN
cord-296347-fanlvxqs	976	7	virus	virus	NN
cord-296347-fanlvxqs	977	1	M153R	M153R	NNP
cord-296347-fanlvxqs	977	2	catalyze	catalyze	VBP
cord-296347-fanlvxqs	977	3	ubiquitination	ubiquitination	NN
cord-296347-fanlvxqs	977	4	of	of	IN
cord-296347-fanlvxqs	977	5	cell	cell	NN
cord-296347-fanlvxqs	977	6	surface	surface	NN
cord-296347-fanlvxqs	977	7	class	class	NN
cord-296347-fanlvxqs	977	8	I	-PRON-	PRP
cord-296347-fanlvxqs	977	9	MHC	MHC	NNP
cord-296347-fanlvxqs	977	10	HC	HC	NNP
cord-296347-fanlvxqs	977	11	,	,	,
cord-296347-fanlvxqs	977	12	thus	thus	RB
cord-296347-fanlvxqs	977	13	providing	provide	VBG
cord-296347-fanlvxqs	977	14	the	the	DT
cord-296347-fanlvxqs	977	15	trigger	trigger	NN
cord-296347-fanlvxqs	977	16	for	for	IN
cord-296347-fanlvxqs	977	17	their	-PRON-	PRP$
cord-296347-fanlvxqs	977	18	internalization	internalization	NN
cord-296347-fanlvxqs	977	19	from	from	IN
cord-296347-fanlvxqs	977	20	the	the	DT
cord-296347-fanlvxqs	977	21	cell	cell	NN
cord-296347-fanlvxqs	977	22	membrane	membrane	NN
cord-296347-fanlvxqs	977	23	,	,	,
cord-296347-fanlvxqs	977	24	as	as	RB
cord-296347-fanlvxqs	977	25	well	well	RB
cord-296347-fanlvxqs	977	26	as	as	IN
cord-296347-fanlvxqs	977	27	for	for	IN
cord-296347-fanlvxqs	977	28	sorting	sort	VBG
cord-296347-fanlvxqs	977	29	through	through	IN
cord-296347-fanlvxqs	977	30	MVB	MVB	NNP
cord-296347-fanlvxqs	977	31	formation	formation	NN
cord-296347-fanlvxqs	977	32	to	to	IN
cord-296347-fanlvxqs	977	33	lysosomal	lysosomal	JJ
cord-296347-fanlvxqs	977	34	degradation	degradation	NN
cord-296347-fanlvxqs	977	35	(	(	-LRB-
cord-296347-fanlvxqs	977	36	Duncan	Duncan	NNP
cord-296347-fanlvxqs	977	37	et	et	NNP
cord-296347-fanlvxqs	977	38	al	al	NNP
cord-296347-fanlvxqs	977	39	.	.	NNP
cord-296347-fanlvxqs	977	40	,	,	,
cord-296347-fanlvxqs	977	41	2006	2006	CD
cord-296347-fanlvxqs	977	42	)	)	-RRB-
cord-296347-fanlvxqs	977	43	.	.	.
cord-296347-fanlvxqs	978	1	In	in	IN
cord-296347-fanlvxqs	978	2	addition	addition	NN
cord-296347-fanlvxqs	978	3	to	to	IN
cord-296347-fanlvxqs	978	4	downregulation	downregulation	NN
cord-296347-fanlvxqs	978	5	of	of	IN
cord-296347-fanlvxqs	978	6	class	class	NN
cord-296347-fanlvxqs	978	7	I	-PRON-	PRP
cord-296347-fanlvxqs	978	8	MHC	MHC	NNP
cord-296347-fanlvxqs	978	9	molecules	molecule	NNS
cord-296347-fanlvxqs	978	10	,	,	,
cord-296347-fanlvxqs	978	11	some	some	DT
cord-296347-fanlvxqs	978	12	of	of	IN
cord-296347-fanlvxqs	978	13	these	these	DT
cord-296347-fanlvxqs	978	14	K3	K3	NNP
cord-296347-fanlvxqs	978	15	homologues	homologue	NNS
cord-296347-fanlvxqs	978	16	target	target	VBP
cord-296347-fanlvxqs	978	17	the	the	DT
cord-296347-fanlvxqs	978	18	lymphocyte	lymphocyte	NN
cord-296347-fanlvxqs	978	19	costimulatory	costimulatory	NN
cord-296347-fanlvxqs	978	20	molecules	molecule	NNS
cord-296347-fanlvxqs	979	1	CD86	CD86	NNP
cord-296347-fanlvxqs	979	2	(	(	-LRB-
cord-296347-fanlvxqs	979	3	B7.2	B7.2	JJS
cord-296347-fanlvxqs	979	4	)	)	-RRB-
cord-296347-fanlvxqs	979	5	and	and	CC
cord-296347-fanlvxqs	979	6	intercellular	intercellular	JJ
cord-296347-fanlvxqs	979	7	adhesion	adhesion	NN
cord-296347-fanlvxqs	979	8	molecule	molecule	NN
cord-296347-fanlvxqs	979	9	ICAM-1	icam-1	NN
cord-296347-fanlvxqs	979	10	,	,	,
cord-296347-fanlvxqs	979	11	CD1d	CD1d	NNP
cord-296347-fanlvxqs	979	12	,	,	,
cord-296347-fanlvxqs	979	13	and	and	CC
cord-296347-fanlvxqs	979	14	CD4	CD4	NNP
cord-296347-fanlvxqs	979	15	(	(	-LRB-
cord-296347-fanlvxqs	979	16	Coscoy	Coscoy	NNP
cord-296347-fanlvxqs	979	17	and	and	CC
cord-296347-fanlvxqs	979	18	Ganem	Ganem	NNP
cord-296347-fanlvxqs	979	19	,	,	,
cord-296347-fanlvxqs	979	20	2003	2003	CD
cord-296347-fanlvxqs	979	21	;	;	:
cord-296347-fanlvxqs	980	1	Coscoy	Coscoy	NNP
cord-296347-fanlvxqs	980	2	et	et	FW
cord-296347-fanlvxqs	980	3	al	al	NNP
cord-296347-fanlvxqs	980	4	.	.	NNP
cord-296347-fanlvxqs	980	5	,	,	,
cord-296347-fanlvxqs	980	6	2001	2001	CD
cord-296347-fanlvxqs	980	7	;	;	:
cord-296347-fanlvxqs	980	8	Lehner	Lehner	NNP
cord-296347-fanlvxqs	980	9	et	et	NNP
cord-296347-fanlvxqs	980	10	al	al	NNP
cord-296347-fanlvxqs	980	11	.	.	NNP
cord-296347-fanlvxqs	980	12	,	,	,
cord-296347-fanlvxqs	980	13	2005	2005	CD
cord-296347-fanlvxqs	981	1	;	;	:
cord-296347-fanlvxqs	981	2	Mansouri	Mansouri	NNP
cord-296347-fanlvxqs	981	3	et	et	NNP
cord-296347-fanlvxqs	981	4	al	al	NNP
cord-296347-fanlvxqs	981	5	.	.	NNP
cord-296347-fanlvxqs	981	6	,	,	,
cord-296347-fanlvxqs	981	7	2003	2003	CD
cord-296347-fanlvxqs	981	8	)	)	-RRB-
cord-296347-fanlvxqs	981	9	,	,	,
cord-296347-fanlvxqs	981	10	as	as	RB
cord-296347-fanlvxqs	981	11	well	well	RB
cord-296347-fanlvxqs	981	12	as	as	IN
cord-296347-fanlvxqs	981	13	the	the	DT
cord-296347-fanlvxqs	981	14	Fas	Fas	NNP
cord-296347-fanlvxqs	981	15	/	/	SYM
cord-296347-fanlvxqs	981	16	CD95	CD95	NNP
cord-296347-fanlvxqs	981	17	death	death	NN
cord-296347-fanlvxqs	981	18	receptor	receptor	NN
cord-296347-fanlvxqs	981	19	(	(	-LRB-
cord-296347-fanlvxqs	981	20	Collin	Collin	NNP
cord-296347-fanlvxqs	981	21	et	et	NNP
cord-296347-fanlvxqs	981	22	al	al	NNP
cord-296347-fanlvxqs	981	23	.	.	NNP
cord-296347-fanlvxqs	981	24	,	,	,
cord-296347-fanlvxqs	981	25	2005	2005	CD
cord-296347-fanlvxqs	981	26	;	;	:
cord-296347-fanlvxqs	981	27	Guerin	Guerin	NNP
cord-296347-fanlvxqs	981	28	et	et	NNP
cord-296347-fanlvxqs	981	29	al	al	NNP
cord-296347-fanlvxqs	981	30	.	.	NNP
cord-296347-fanlvxqs	981	31	,	,	,
cord-296347-fanlvxqs	981	32	2002	2002	CD
cord-296347-fanlvxqs	981	33	)	)	-RRB-
cord-296347-fanlvxqs	981	34	.	.	.
cord-296347-fanlvxqs	982	1	By	by	IN
cord-296347-fanlvxqs	982	2	targeting	target	VBG
cord-296347-fanlvxqs	982	3	not	not	RB
cord-296347-fanlvxqs	982	4	only	only	RB
cord-296347-fanlvxqs	982	5	class	class	NN
cord-296347-fanlvxqs	982	6	I	-PRON-	PRP
cord-296347-fanlvxqs	982	7	MHC	MHC	NNP
cord-296347-fanlvxqs	982	8	molecules	molecule	NNS
cord-296347-fanlvxqs	982	9	,	,	,
cord-296347-fanlvxqs	982	10	the	the	DT
cord-296347-fanlvxqs	982	11	viral	viral	JJ
cord-296347-fanlvxqs	982	12	K3	K3	NNP
cord-296347-fanlvxqs	982	13	homologues	homologue	NNS
cord-296347-fanlvxqs	982	14	are	be	VBP
cord-296347-fanlvxqs	982	15	adding	add	VBG
cord-296347-fanlvxqs	982	16	an	an	DT
cord-296347-fanlvxqs	982	17	extra	extra	JJ
cord-296347-fanlvxqs	982	18	layer	layer	NN
cord-296347-fanlvxqs	982	19	of	of	IN
cord-296347-fanlvxqs	982	20	protection	protection	NN
cord-296347-fanlvxqs	982	21	predicted	predict	VBN
cord-296347-fanlvxqs	982	22	to	to	TO
cord-296347-fanlvxqs	982	23	be	be	VB
cord-296347-fanlvxqs	982	24	important	important	JJ
cord-296347-fanlvxqs	982	25	for	for	IN
cord-296347-fanlvxqs	982	26	viral	viral	JJ
cord-296347-fanlvxqs	982	27	escape	escape	NN
cord-296347-fanlvxqs	982	28	after	after	IN
cord-296347-fanlvxqs	982	29	reactivation	reactivation	NN
cord-296347-fanlvxqs	982	30	from	from	IN
cord-296347-fanlvxqs	982	31	latency	latency	NNP
cord-296347-fanlvxqs	983	1	(	(	-LRB-
cord-296347-fanlvxqs	983	2	Lehner	Lehner	NNP
cord-296347-fanlvxqs	983	3	et	et	NNP
cord-296347-fanlvxqs	983	4	al	al	NNP
cord-296347-fanlvxqs	983	5	.	.	NNP
cord-296347-fanlvxqs	983	6	,	,	,
cord-296347-fanlvxqs	983	7	2005	2005	CD
cord-296347-fanlvxqs	983	8	)	)	-RRB-
cord-296347-fanlvxqs	983	9	.	.	.
cord-296347-fanlvxqs	984	1	The	the	DT
cord-296347-fanlvxqs	984	2	K3	K3	NNP
cord-296347-fanlvxqs	984	3	homologues	homologue	NNS
cord-296347-fanlvxqs	984	4	are	be	VBP
cord-296347-fanlvxqs	984	5	most	most	RBS
cord-296347-fanlvxqs	984	6	likely	likely	RB
cord-296347-fanlvxqs	984	7	making	make	VBG
cord-296347-fanlvxqs	984	8	use	use	NN
cord-296347-fanlvxqs	984	9	of	of	IN
cord-296347-fanlvxqs	984	10	old	old	JJ
cord-296347-fanlvxqs	984	11	ideas	idea	NNS
cord-296347-fanlvxqs	984	12	:	:	:
cord-296347-fanlvxqs	985	1	the	the	DT
cord-296347-fanlvxqs	985	2	mechanisms	mechanism	NNS
cord-296347-fanlvxqs	985	3	used	use	VBN
cord-296347-fanlvxqs	985	4	by	by	IN
cord-296347-fanlvxqs	985	5	the	the	DT
cord-296347-fanlvxqs	985	6	viral	viral	JJ
cord-296347-fanlvxqs	985	7	Ub	Ub	NNP
cord-296347-fanlvxqs	985	8	ligases	ligase	NNS
cord-296347-fanlvxqs	985	9	have	have	VBP
cord-296347-fanlvxqs	985	10	probably	probably	RB
cord-296347-fanlvxqs	985	11	been	be	VBN
cord-296347-fanlvxqs	985	12	'	'	''
cord-296347-fanlvxqs	985	13	'	'	''
cord-296347-fanlvxqs	985	14	borrowed	borrow	VBN
cord-296347-fanlvxqs	985	15	'	'	''
cord-296347-fanlvxqs	985	16	'	'	''
cord-296347-fanlvxqs	985	17	from	from	IN
cord-296347-fanlvxqs	985	18	their	-PRON-	PRP$
cord-296347-fanlvxqs	985	19	mammalian	mammalian	JJ
cord-296347-fanlvxqs	985	20	counterparts	counterpart	NNS
cord-296347-fanlvxqs	985	21	,	,	,
cord-296347-fanlvxqs	985	22	the	the	DT
cord-296347-fanlvxqs	985	23	MARCH	MARCH	NNP
cord-296347-fanlvxqs	985	24	proteins	protein	NNS
cord-296347-fanlvxqs	985	25	,	,	,
cord-296347-fanlvxqs	985	26	and	and	CC
cord-296347-fanlvxqs	985	27	will	will	MD
cord-296347-fanlvxqs	985	28	certainly	certainly	RB
cord-296347-fanlvxqs	985	29	continue	continue	VB
cord-296347-fanlvxqs	985	30	to	to	TO
cord-296347-fanlvxqs	985	31	yield	yield	VB
cord-296347-fanlvxqs	985	32	insights	insight	NNS
cord-296347-fanlvxqs	985	33	into	into	IN
cord-296347-fanlvxqs	985	34	the	the	DT
cord-296347-fanlvxqs	985	35	Ub	Ub	NNP
cord-296347-fanlvxqs	985	36	-	-	HYPH
cord-296347-fanlvxqs	985	37	proteasome	proteasome	NN
cord-296347-fanlvxqs	985	38	system	system	NN
cord-296347-fanlvxqs	985	39	.	.	.
cord-296347-fanlvxqs	986	1	A	a	DT
cord-296347-fanlvxqs	986	2	bacterial	bacterial	JJ
cord-296347-fanlvxqs	986	3	E3	e3	NN
cord-296347-fanlvxqs	986	4	ligase	ligase	NN
cord-296347-fanlvxqs	986	5	was	be	VBD
cord-296347-fanlvxqs	986	6	recently	recently	RB
cord-296347-fanlvxqs	986	7	shown	show	VBN
cord-296347-fanlvxqs	986	8	to	to	TO
cord-296347-fanlvxqs	986	9	inactivate	inactivate	VB
cord-296347-fanlvxqs	986	10	another	another	DT
cord-296347-fanlvxqs	986	11	type	type	NN
cord-296347-fanlvxqs	986	12	of	of	IN
cord-296347-fanlvxqs	986	13	immune	immune	JJ
cord-296347-fanlvxqs	986	14	response	response	NN
cord-296347-fanlvxqs	986	15	in	in	IN
cord-296347-fanlvxqs	986	16	plants	plant	NNS
cord-296347-fanlvxqs	986	17	(	(	-LRB-
cord-296347-fanlvxqs	986	18	Janjusevic	Janjusevic	NNP
cord-296347-fanlvxqs	986	19	et	et	NNP
cord-296347-fanlvxqs	986	20	al	al	NNP
cord-296347-fanlvxqs	986	21	.	.	NNP
cord-296347-fanlvxqs	986	22	,	,	,
cord-296347-fanlvxqs	986	23	2006	2006	CD
cord-296347-fanlvxqs	986	24	)	)	-RRB-
cord-296347-fanlvxqs	986	25	.	.	.
cord-296347-fanlvxqs	987	1	Antipathogen	Antipathogen	NNP
cord-296347-fanlvxqs	987	2	responses	response	NNS
cord-296347-fanlvxqs	987	3	in	in	IN
cord-296347-fanlvxqs	987	4	plants	plant	NNS
cord-296347-fanlvxqs	987	5	,	,	,
cord-296347-fanlvxqs	987	6	although	although	IN
cord-296347-fanlvxqs	987	7	not	not	RB
cord-296347-fanlvxqs	987	8	as	as	RB
cord-296347-fanlvxqs	987	9	sophisticated	sophisticated	JJ
cord-296347-fanlvxqs	987	10	as	as	IN
cord-296347-fanlvxqs	987	11	those	those	DT
cord-296347-fanlvxqs	987	12	afforded	afford	VBN
cord-296347-fanlvxqs	987	13	by	by	IN
cord-296347-fanlvxqs	987	14	the	the	DT
cord-296347-fanlvxqs	987	15	vertebrate	vertebrate	JJ
cord-296347-fanlvxqs	987	16	immune	immune	JJ
cord-296347-fanlvxqs	987	17	system	system	NN
cord-296347-fanlvxqs	987	18	,	,	,
cord-296347-fanlvxqs	987	19	are	be	VBP
cord-296347-fanlvxqs	987	20	nevertheless	nevertheless	RB
cord-296347-fanlvxqs	987	21	quite	quite	RB
cord-296347-fanlvxqs	987	22	efficient	efficient	JJ
cord-296347-fanlvxqs	987	23	.	.	.
cord-296347-fanlvxqs	988	1	One	one	CD
cord-296347-fanlvxqs	988	2	mechanism	mechanism	NN
cord-296347-fanlvxqs	988	3	,	,	,
cord-296347-fanlvxqs	988	4	immunity	immunity	NN
cord-296347-fanlvxqs	988	5	-	-	HYPH
cord-296347-fanlvxqs	988	6	induced	induce	VBN
cord-296347-fanlvxqs	988	7	programmed	program	VBN
cord-296347-fanlvxqs	988	8	cell	cell	NN
cord-296347-fanlvxqs	988	9	death	death	NN
cord-296347-fanlvxqs	988	10	(	(	-LRB-
cord-296347-fanlvxqs	988	11	PCD	PCD	NNP
cord-296347-fanlvxqs	988	12	)	)	-RRB-
cord-296347-fanlvxqs	988	13	,	,	,
cord-296347-fanlvxqs	988	14	is	be	VBZ
cord-296347-fanlvxqs	988	15	a	a	DT
cord-296347-fanlvxqs	988	16	response	response	NN
cord-296347-fanlvxqs	988	17	that	that	WDT
cord-296347-fanlvxqs	988	18	sacrifices	sacrifice	VBZ
cord-296347-fanlvxqs	988	19	a	a	DT
cord-296347-fanlvxqs	988	20	limited	limited	JJ
cord-296347-fanlvxqs	988	21	portion	portion	NN
cord-296347-fanlvxqs	988	22	of	of	IN
cord-296347-fanlvxqs	988	23	the	the	DT
cord-296347-fanlvxqs	988	24	plant	plant	NN
cord-296347-fanlvxqs	988	25	to	to	TO
cord-296347-fanlvxqs	988	26	limit	limit	VB
cord-296347-fanlvxqs	988	27	spread	spread	NN
cord-296347-fanlvxqs	988	28	of	of	IN
cord-296347-fanlvxqs	988	29	the	the	DT
cord-296347-fanlvxqs	988	30	infection	infection	NN
cord-296347-fanlvxqs	988	31	.	.	.
cord-296347-fanlvxqs	989	1	The	the	DT
cord-296347-fanlvxqs	989	2	Pseudomonas	Pseudomonas	NNP
cord-296347-fanlvxqs	989	3	syringae	syringae	NN
cord-296347-fanlvxqs	989	4	bacterium	bacterium	NN
cord-296347-fanlvxqs	989	5	,	,	,
cord-296347-fanlvxqs	989	6	which	which	WDT
cord-296347-fanlvxqs	989	7	causes	cause	VBZ
cord-296347-fanlvxqs	989	8	disease	disease	NN
cord-296347-fanlvxqs	989	9	in	in	IN
cord-296347-fanlvxqs	989	10	tomato	tomato	NN
cord-296347-fanlvxqs	989	11	and	and	CC
cord-296347-fanlvxqs	989	12	Arabidopsis	Arabidopsis	NNP
cord-296347-fanlvxqs	989	13	,	,	,
cord-296347-fanlvxqs	989	14	delivers	deliver	VBZ
cord-296347-fanlvxqs	989	15	its	-PRON-	PRP$
cord-296347-fanlvxqs	989	16	AvrPtoB	avrptob	NN
cord-296347-fanlvxqs	989	17	protein	protein	NN
cord-296347-fanlvxqs	989	18	into	into	IN
cord-296347-fanlvxqs	989	19	plant	plant	NN
cord-296347-fanlvxqs	989	20	cells	cell	NNS
cord-296347-fanlvxqs	989	21	through	through	IN
cord-296347-fanlvxqs	989	22	a	a	DT
cord-296347-fanlvxqs	989	23	type	type	NN
cord-296347-fanlvxqs	989	24	III	iii	CD
cord-296347-fanlvxqs	989	25	secretion	secretion	NN
cord-296347-fanlvxqs	989	26	system	system	NN
cord-296347-fanlvxqs	989	27	.	.	.
cord-296347-fanlvxqs	990	1	AvrPtoB	AvrPtoB	NNP
cord-296347-fanlvxqs	990	2	can	can	MD
cord-296347-fanlvxqs	990	3	inhibit	inhibit	VB
cord-296347-fanlvxqs	990	4	PCD	PCD	NNP
cord-296347-fanlvxqs	990	5	in	in	IN
cord-296347-fanlvxqs	990	6	susceptible	susceptible	JJ
cord-296347-fanlvxqs	990	7	hosts	host	NNS
cord-296347-fanlvxqs	990	8	,	,	,
cord-296347-fanlvxqs	990	9	allowing	allow	VBG
cord-296347-fanlvxqs	990	10	Pseudomonas	Pseudomonas	NNP
cord-296347-fanlvxqs	990	11	to	to	TO
cord-296347-fanlvxqs	990	12	cause	cause	VB
cord-296347-fanlvxqs	990	13	systemic	systemic	JJ
cord-296347-fanlvxqs	990	14	infection	infection	NN
cord-296347-fanlvxqs	990	15	and	and	CC
cord-296347-fanlvxqs	990	16	disease	disease	NN
cord-296347-fanlvxqs	990	17	.	.	.
cord-296347-fanlvxqs	991	1	The	the	DT
cord-296347-fanlvxqs	991	2	AvrPtoB	avrptob	NN
cord-296347-fanlvxqs	991	3	C	c	NN
cord-296347-fanlvxqs	991	4	-	-	HYPH
cord-296347-fanlvxqs	991	5	terminus	terminus	NN
cord-296347-fanlvxqs	991	6	encodes	encode	VBZ
cord-296347-fanlvxqs	991	7	a	a	DT
cord-296347-fanlvxqs	991	8	U	U	NNP
cord-296347-fanlvxqs	991	9	-	-	HYPH
cord-296347-fanlvxqs	991	10	box	box	NN
cord-296347-fanlvxqs	991	11	E3	e3	NN
cord-296347-fanlvxqs	991	12	ligase	ligase	NN
cord-296347-fanlvxqs	991	13	activity	activity	NN
cord-296347-fanlvxqs	991	14	necessary	necessary	JJ
cord-296347-fanlvxqs	991	15	for	for	IN
cord-296347-fanlvxqs	991	16	the	the	DT
cord-296347-fanlvxqs	991	17	pathogenic	pathogenic	JJ
cord-296347-fanlvxqs	991	18	role	role	NN
cord-296347-fanlvxqs	991	19	of	of	IN
cord-296347-fanlvxqs	991	20	AvrPtoB	avrptob	NN
cord-296347-fanlvxqs	991	21	,	,	,
cord-296347-fanlvxqs	991	22	since	since	IN
cord-296347-fanlvxqs	991	23	mutation	mutation	NN
cord-296347-fanlvxqs	991	24	of	of	IN
cord-296347-fanlvxqs	991	25	the	the	DT
cord-296347-fanlvxqs	991	26	putative	putative	JJ
cord-296347-fanlvxqs	991	27	E2-recruitment	E2-recruitment	NNP
cord-296347-fanlvxqs	991	28	sites	site	NNS
cord-296347-fanlvxqs	991	29	abolishes	abolish	VBZ
cord-296347-fanlvxqs	991	30	the	the	DT
cord-296347-fanlvxqs	991	31	anti	anti	JJ
cord-296347-fanlvxqs	991	32	-	-	JJ
cord-296347-fanlvxqs	991	33	PCD	pcd	NN
cord-296347-fanlvxqs	991	34	and	and	CC
cord-296347-fanlvxqs	991	35	virulence	virulence	NN
cord-296347-fanlvxqs	991	36	activities	activity	NNS
cord-296347-fanlvxqs	991	37	of	of	IN
cord-296347-fanlvxqs	991	38	the	the	DT
cord-296347-fanlvxqs	991	39	AvrPtoB	AvrPtoB	NNP
cord-296347-fanlvxqs	991	40	protein	protein	NN
cord-296347-fanlvxqs	991	41	(	(	-LRB-
cord-296347-fanlvxqs	991	42	Janjusevic	Janjusevic	NNP
cord-296347-fanlvxqs	991	43	et	et	FW
cord-296347-fanlvxqs	991	44	al	al	NNP
cord-296347-fanlvxqs	991	45	.	.	NNP
cord-296347-fanlvxqs	991	46	,	,	,
cord-296347-fanlvxqs	991	47	2006	2006	CD
cord-296347-fanlvxqs	991	48	)	)	-RRB-
cord-296347-fanlvxqs	991	49	.	.	.
cord-296347-fanlvxqs	992	1	Determining	determine	VBG
cord-296347-fanlvxqs	992	2	the	the	DT
cord-296347-fanlvxqs	992	3	host	host	NN
cord-296347-fanlvxqs	992	4	targets	target	NNS
cord-296347-fanlvxqs	992	5	of	of	IN
cord-296347-fanlvxqs	992	6	the	the	DT
cord-296347-fanlvxqs	992	7	Pseudomonas	Pseudomonas	NNP
cord-296347-fanlvxqs	992	8	E3	E3	NNP
cord-296347-fanlvxqs	992	9	will	will	MD
cord-296347-fanlvxqs	992	10	be	be	VB
cord-296347-fanlvxqs	992	11	crucial	crucial	JJ
cord-296347-fanlvxqs	992	12	in	in	IN
cord-296347-fanlvxqs	992	13	clarifying	clarify	VBG
cord-296347-fanlvxqs	992	14	its	-PRON-	PRP$
cord-296347-fanlvxqs	992	15	mechanism	mechanism	NN
cord-296347-fanlvxqs	992	16	of	of	IN
cord-296347-fanlvxqs	992	17	action	action	NN
cord-296347-fanlvxqs	992	18	and	and	CC
cord-296347-fanlvxqs	992	19	might	may	MD
cord-296347-fanlvxqs	992	20	even	even	RB
cord-296347-fanlvxqs	992	21	explain	explain	VB
cord-296347-fanlvxqs	992	22	plant	plant	NN
cord-296347-fanlvxqs	992	23	susceptibility	susceptibility	NN
cord-296347-fanlvxqs	992	24	to	to	IN
cord-296347-fanlvxqs	992	25	infection	infection	NN
cord-296347-fanlvxqs	992	26	.	.	.
cord-296347-fanlvxqs	993	1	Such	such	JJ
cord-296347-fanlvxqs	993	2	experiments	experiment	NNS
cord-296347-fanlvxqs	993	3	may	may	MD
cord-296347-fanlvxqs	993	4	also	also	RB
cord-296347-fanlvxqs	993	5	assist	assist	VB
cord-296347-fanlvxqs	993	6	in	in	IN
cord-296347-fanlvxqs	993	7	the	the	DT
cord-296347-fanlvxqs	993	8	identification	identification	NN
cord-296347-fanlvxqs	993	9	of	of	IN
cord-296347-fanlvxqs	993	10	similar	similar	JJ
cord-296347-fanlvxqs	993	11	targets	target	NNS
cord-296347-fanlvxqs	993	12	in	in	IN
cord-296347-fanlvxqs	993	13	mammalian	mammalian	JJ
cord-296347-fanlvxqs	993	14	species	specie	NNS
cord-296347-fanlvxqs	993	15	infected	infect	VBN
cord-296347-fanlvxqs	993	16	with	with	IN
cord-296347-fanlvxqs	993	17	comparable	comparable	JJ
cord-296347-fanlvxqs	993	18	Gram	gram	NN
cord-296347-fanlvxqs	993	19	-	-	HYPH
cord-296347-fanlvxqs	993	20	negative	negative	JJ
cord-296347-fanlvxqs	993	21	microbes	microbe	NNS
cord-296347-fanlvxqs	993	22	.	.	.
cord-296347-fanlvxqs	994	1	Furthermore	furthermore	RB
cord-296347-fanlvxqs	994	2	,	,	,
cord-296347-fanlvxqs	994	3	it	-PRON-	PRP
cord-296347-fanlvxqs	994	4	is	be	VBZ
cord-296347-fanlvxqs	994	5	rather	rather	RB
cord-296347-fanlvxqs	994	6	striking	strike	VBG
cord-296347-fanlvxqs	994	7	that	that	IN
cord-296347-fanlvxqs	994	8	another	another	DT
cord-296347-fanlvxqs	994	9	pathogen	pathogen	NN
cord-296347-fanlvxqs	994	10	uses	use	VBZ
cord-296347-fanlvxqs	994	11	a	a	DT
cord-296347-fanlvxqs	994	12	mimic	mimic	NN
cord-296347-fanlvxqs	994	13	of	of	IN
cord-296347-fanlvxqs	994	14	a	a	DT
cord-296347-fanlvxqs	994	15	host	host	NN
cord-296347-fanlvxqs	994	16	E3	e3	NN
cord-296347-fanlvxqs	994	17	ligase	ligase	NN
cord-296347-fanlvxqs	994	18	to	to	TO
cord-296347-fanlvxqs	994	19	encode	encode	VB
cord-296347-fanlvxqs	994	20	an	an	DT
cord-296347-fanlvxqs	994	21	immunomodulatory	immunomodulatory	JJ
cord-296347-fanlvxqs	994	22	function	function	NN
cord-296347-fanlvxqs	994	23	.	.	.
cord-296347-fanlvxqs	995	1	There	there	EX
cord-296347-fanlvxqs	995	2	are	be	VBP
cord-296347-fanlvxqs	995	3	bound	bind	VBN
cord-296347-fanlvxqs	995	4	to	to	TO
cord-296347-fanlvxqs	995	5	be	be	VB
cord-296347-fanlvxqs	995	6	others	other	NNS
cord-296347-fanlvxqs	995	7	.	.	.
cord-296347-fanlvxqs	996	1	Mumps	mumps	NN
cord-296347-fanlvxqs	996	2	virus	virus	NN
cord-296347-fanlvxqs	996	3	and	and	CC
cord-296347-fanlvxqs	996	4	other	other	JJ
cord-296347-fanlvxqs	996	5	Paramyxoviridae	Paramyxoviridae	NNP
cord-296347-fanlvxqs	996	6	family	family	NN
cord-296347-fanlvxqs	996	7	members	member	NNS
cord-296347-fanlvxqs	996	8	hijack	hijack	VBP
cord-296347-fanlvxqs	996	9	the	the	DT
cord-296347-fanlvxqs	996	10	Cullin-4A	Cullin-4A	NNP
cord-296347-fanlvxqs	996	11	-	-	HYPH
cord-296347-fanlvxqs	996	12	SCF	SCF	NNP
cord-296347-fanlvxqs	996	13	b	b	NNP
cord-296347-fanlvxqs	996	14	-	-	:
cord-296347-fanlvxqs	996	15	TrCP	TrCP	NNP
cord-296347-fanlvxqs	996	16	E3	e3	NN
cord-296347-fanlvxqs	996	17	ligase	ligase	NN
cord-296347-fanlvxqs	996	18	to	to	TO
cord-296347-fanlvxqs	996	19	suppress	suppress	VB
cord-296347-fanlvxqs	996	20	IFN	IFN	NNP
cord-296347-fanlvxqs	996	21	-	-	:
cord-296347-fanlvxqs	996	22	as	as	RB
cord-296347-fanlvxqs	996	23	well	well	RB
cord-296347-fanlvxqs	996	24	as	as	IN
cord-296347-fanlvxqs	996	25	IL-6-mediated	il-6-mediate	VBN
cord-296347-fanlvxqs	996	26	signaling	signal	VBG
cord-296347-fanlvxqs	996	27	(	(	-LRB-
cord-296347-fanlvxqs	996	28	Ulane	Ulane	NNP
cord-296347-fanlvxqs	996	29	et	et	NNP
cord-296347-fanlvxqs	996	30	al	al	NNP
cord-296347-fanlvxqs	996	31	.	.	NNP
cord-296347-fanlvxqs	996	32	,	,	,
cord-296347-fanlvxqs	996	33	2003	2003	CD
cord-296347-fanlvxqs	996	34	)	)	-RRB-
cord-296347-fanlvxqs	996	35	,	,	,
cord-296347-fanlvxqs	996	36	important	important	JJ
cord-296347-fanlvxqs	996	37	for	for	IN
cord-296347-fanlvxqs	996	38	control	control	NN
cord-296347-fanlvxqs	996	39	of	of	IN
cord-296347-fanlvxqs	996	40	inflammation	inflammation	NN
cord-296347-fanlvxqs	996	41	and	and	CC
cord-296347-fanlvxqs	996	42	apoptosis	apoptosis	NN
cord-296347-fanlvxqs	996	43	during	during	IN
cord-296347-fanlvxqs	996	44	inflammation	inflammation	NN
cord-296347-fanlvxqs	996	45	(	(	-LRB-
cord-296347-fanlvxqs	996	46	Hodge	Hodge	NNP
cord-296347-fanlvxqs	996	47	et	et	NNP
cord-296347-fanlvxqs	996	48	al	al	NNP
cord-296347-fanlvxqs	996	49	.	.	NNP
cord-296347-fanlvxqs	996	50	,	,	,
cord-296347-fanlvxqs	996	51	2005	2005	CD
cord-296347-fanlvxqs	996	52	)	)	-RRB-
cord-296347-fanlvxqs	996	53	.	.	.
cord-296347-fanlvxqs	997	1	IFN	IFN	NNP
cord-296347-fanlvxqs	997	2	and	and	CC
cord-296347-fanlvxqs	997	3	IL-6	IL-6	NNP
cord-296347-fanlvxqs	997	4	signaling	signal	VBG
cord-296347-fanlvxqs	997	5	activates	activate	VBZ
cord-296347-fanlvxqs	997	6	their	-PRON-	PRP$
cord-296347-fanlvxqs	997	7	cognate	cognate	JJ
cord-296347-fanlvxqs	997	8	STAT	stat	NN
cord-296347-fanlvxqs	997	9	factors	factor	NNS
cord-296347-fanlvxqs	997	10	and	and	CC
cord-296347-fanlvxqs	997	11	transcription	transcription	NN
cord-296347-fanlvxqs	997	12	of	of	IN
cord-296347-fanlvxqs	997	13	genes	gene	NNS
cord-296347-fanlvxqs	997	14	involved	involve	VBN
cord-296347-fanlvxqs	997	15	in	in	IN
cord-296347-fanlvxqs	997	16	IFN	IFN	NNP
cord-296347-fanlvxqs	997	17	and	and	CC
cord-296347-fanlvxqs	997	18	cytokine	cytokine	NN
cord-296347-fanlvxqs	997	19	signaling	signaling	NN
cord-296347-fanlvxqs	997	20	.	.	.
cord-296347-fanlvxqs	998	1	Some	some	DT
cord-296347-fanlvxqs	998	2	of	of	IN
cord-296347-fanlvxqs	998	3	these	these	DT
cord-296347-fanlvxqs	998	4	paramyxoviruses	paramyxovirus	NNS
cord-296347-fanlvxqs	998	5	use	use	VBP
cord-296347-fanlvxqs	998	6	their	-PRON-	PRP$
cord-296347-fanlvxqs	998	7	V	v	NN
cord-296347-fanlvxqs	998	8	protein	protein	NN
cord-296347-fanlvxqs	998	9	to	to	TO
cord-296347-fanlvxqs	998	10	bind	bind	VB
cord-296347-fanlvxqs	998	11	DDB1	DDB1	NNP
cord-296347-fanlvxqs	998	12	,	,	,
cord-296347-fanlvxqs	998	13	the	the	DT
cord-296347-fanlvxqs	998	14	Cullin-4A	Cullin-4A	NNP
cord-296347-fanlvxqs	998	15	-	-	HYPH
cord-296347-fanlvxqs	998	16	SCF	SCF	NNP
cord-296347-fanlvxqs	998	17	b	b	NNP
cord-296347-fanlvxqs	998	18	-	-	:
cord-296347-fanlvxqs	998	19	TrCP	TrCP	NNP
cord-296347-fanlvxqs	998	20	E3	e3	NN
cord-296347-fanlvxqs	998	21	substrate	substrate	NN
cord-296347-fanlvxqs	998	22	adaptor	adaptor	NN
cord-296347-fanlvxqs	998	23	that	that	WDT
cord-296347-fanlvxqs	998	24	recruits	recruit	VBZ
cord-296347-fanlvxqs	998	25	STAT	stat	NN
cord-296347-fanlvxqs	998	26	proteins	protein	NNS
cord-296347-fanlvxqs	998	27	to	to	IN
cord-296347-fanlvxqs	998	28	the	the	DT
cord-296347-fanlvxqs	998	29	E3	E3	NNP
cord-296347-fanlvxqs	998	30	complex	complex	NN
cord-296347-fanlvxqs	998	31	,	,	,
cord-296347-fanlvxqs	998	32	targeting	target	VBG
cord-296347-fanlvxqs	998	33	STATs	stat	NNS
cord-296347-fanlvxqs	998	34	for	for	IN
cord-296347-fanlvxqs	998	35	proteasome	proteasome	NN
cord-296347-fanlvxqs	998	36	-	-	HYPH
cord-296347-fanlvxqs	998	37	mediated	mediate	VBN
cord-296347-fanlvxqs	998	38	degradati	degradati	NN
cord-296347-fanlvxqs	998	39	on	on	IN
cord-296347-fanlvxqs	998	40	(	(	-LRB-
cord-296347-fanlvxqs	999	1	Li	Li	NNP
cord-296347-fanlvxqs	999	2	et	et	NNP
cord-296347-fanlvxqs	999	3	al	al	NNP
cord-296347-fanlvxqs	999	4	.	.	NNP
cord-296347-fanlvxqs	999	5	,	,	,
cord-296347-fanlvxqs	999	6	2006b	2006b	CD
cord-296347-fanlvxqs	999	7	;	;	:
cord-296347-fanlvxqs	1000	1	Ulane	Ulane	NNP
cord-296347-fanlvxqs	1000	2	and	and	CC
cord-296347-fanlvxqs	1000	3	Horva	Horva	NNP
cord-296347-fanlvxqs	1000	4	th	th	XX
cord-296347-fanlvxqs	1000	5	,	,	,
cord-296347-fanlvxqs	1000	6	2002	2002	CD
cord-296347-fanlvxqs	1000	7	;	;	:
cord-296347-fanlvxqs	1000	8	Ulane	Ulane	NNP
cord-296347-fanlvxqs	1000	9	et	et	NNP
cord-296347-fanlvxqs	1000	10	al	al	NNP
cord-296347-fanlvxqs	1000	11	.	.	NNP
cord-296347-fanlvxqs	1000	12	,	,	,
cord-296347-fanlvxqs	1000	13	2005	2005	CD
cord-296347-fanlvxqs	1000	14	)	)	-RRB-
cord-296347-fanlvxqs	1000	15	.	.	.
cord-296347-fanlvxqs	1001	1	Many	many	JJ
cord-296347-fanlvxqs	1001	2	other	other	JJ
cord-296347-fanlvxqs	1001	3	viru	viru	NNP
cord-296347-fanlvxqs	1001	4	ses	ses	NNP
cord-296347-fanlvxqs	1001	5	targe	targe	NNP
cord-296347-fanlvxqs	1001	6	t	t	NNP
cord-296347-fanlvxqs	1001	7	STAT	STAT	NNP
cord-296347-fanlvxqs	1001	8	transcri	transcri	NNP
cord-296347-fanlvxqs	1001	9	ption	ption	NN
cord-296347-fanlvxqs	1001	10	factors	factor	NNS
cord-296347-fanlvxqs	1001	11	for	for	IN
cord-296347-fanlvxqs	1001	12	protea	protea	NNP
cord-296347-fanlvxqs	1001	13	somal	somal	NNP
cord-296347-fanlvxqs	1001	14	degrad	degrad	NNP
cord-296347-fanlvxqs	1001	15	ation	ation	NNP
cord-296347-fanlvxqs	1002	1	(	(	-LRB-
cord-296347-fanlvxqs	1002	2	Garcin	Garcin	NNP
cord-296347-fanlvxqs	1002	3	et	et	NNP
cord-296347-fanlvxqs	1002	4	al	al	NNP
cord-296347-fanlvxqs	1002	5	.	.	NNP
cord-296347-fanlvxqs	1002	6	,	,	,
cord-296347-fanlvxqs	1002	7	2002	2002	CD
cord-296347-fanlvxqs	1002	8	;	;	:
cord-296347-fanlvxqs	1002	9	Lin	Lin	NNP
cord-296347-fanlvxqs	1002	10	et	et	NNP
cord-296347-fanlvxqs	1002	11	al	al	NNP
cord-296347-fanlvxqs	1002	12	.	.	.
cord-296347-fanlvxqs	1003	1	,	,	,
cord-296347-fanlvxqs	1003	2	2005	2005	CD
cord-296347-fanlvxqs	1003	3	;	;	:
cord-296347-fanlvxqs	1003	4	Ramaswamy	Ramaswamy	NNP
cord-296347-fanlvxqs	1003	5	et	et	NNP
cord-296347-fanlvxqs	1003	6	al	al	NNP
cord-296347-fanlvxqs	1003	7	.	.	NNP
cord-296347-fanlvxqs	1003	8	,	,	,
cord-296347-fanlvxqs	1003	9	2004	2004	CD
cord-296347-fanlvxqs	1003	10	;	;	:
cord-296347-fanlvxqs	1003	11	Zimmermann	Zimmermann	NNP
cord-296347-fanlvxqs	1003	12	et	et	NNP
cord-296347-fanlvxqs	1003	13	al	al	NNP
cord-296347-fanlvxqs	1003	14	.	.	NNP
cord-296347-fanlvxqs	1003	15	,	,	,
cord-296347-fanlvxqs	1003	16	2005	2005	CD
cord-296347-fanlvxqs	1003	17	)	)	-RRB-
cord-296347-fanlvxqs	1003	18	.	.	.
cord-296347-fanlvxqs	1004	1	Recruitment	recruitment	NN
cord-296347-fanlvxqs	1004	2	of	of	IN
cord-296347-fanlvxqs	1004	3	Cullin	Cullin	NNP
cord-296347-fanlvxqs	1004	4	E3s	e3s	NN
cord-296347-fanlvxqs	1004	5	is	be	VBZ
cord-296347-fanlvxqs	1004	6	likely	likely	JJ
cord-296347-fanlvxqs	1004	7	to	to	TO
cord-296347-fanlvxqs	1004	8	be	be	VB
cord-296347-fanlvxqs	1004	9	a	a	DT
cord-296347-fanlvxqs	1004	10	more	more	RBR
cord-296347-fanlvxqs	1004	11	widely	widely	RB
cord-296347-fanlvxqs	1004	12	used	use	VBN
cord-296347-fanlvxqs	1004	13	viral	viral	JJ
cord-296347-fanlvxqs	1004	14	strategy	strategy	NN
cord-296347-fanlvxqs	1004	15	of	of	IN
cord-296347-fanlvxqs	1004	16	interfering	interfere	VBG
cord-296347-fanlvxqs	1004	17	with	with	IN
cord-296347-fanlvxqs	1004	18	IFN	IFN	NNP
cord-296347-fanlvxqs	1004	19	and	and	CC
cord-296347-fanlvxqs	1004	20	cytokine	cytokine	NN
cord-296347-fanlvxqs	1004	21	signaling	signaling	NN
cord-296347-fanlvxqs	1004	22	.	.	.
cord-296347-fanlvxqs	1005	1	The	the	DT
cord-296347-fanlvxqs	1005	2	interleukin-2	interleukin-2	NN
cord-296347-fanlvxqs	1005	3	(	(	-LRB-
cord-296347-fanlvxqs	1005	4	IL-2)-inducible	il-2)-inducible	JJ
cord-296347-fanlvxqs	1005	5	deubiquitinating	deubiquitinating	NN
cord-296347-fanlvxqs	1005	6	enzyme	enzyme	NN
cord-296347-fanlvxqs	1005	7	DUB-2	DUB-2	NNP
cord-296347-fanlvxqs	1005	8	is	be	VBZ
cord-296347-fanlvxqs	1005	9	induced	induce	VBN
cord-296347-fanlvxqs	1005	10	by	by	IN
cord-296347-fanlvxqs	1005	11	IL-2	IL-2	NNP
cord-296347-fanlvxqs	1005	12	stimulation	stimulation	NN
cord-296347-fanlvxqs	1005	13	and	and	CC
cord-296347-fanlvxqs	1005	14	may	may	MD
cord-296347-fanlvxqs	1005	15	regulate	regulate	VB
cord-296347-fanlvxqs	1005	16	IL-2	il-2	NN
cord-296347-fanlvxqs	1005	17	signaling	signal	VBG
cord-296347-fanlvxqs	1005	18	.	.	.
cord-296347-fanlvxqs	1006	1	The	the	DT
cord-296347-fanlvxqs	1006	2	IL-2-inducible	IL-2-inducible	NNP
cord-296347-fanlvxqs	1006	3	DUB-2	DUB-2	NNP
cord-296347-fanlvxqs	1006	4	is	be	VBZ
cord-296347-fanlvxqs	1006	5	constitutively	constitutively	RB
cord-296347-fanlvxqs	1006	6	expressed	express	VBN
cord-296347-fanlvxqs	1006	7	in	in	IN
cord-296347-fanlvxqs	1006	8	cells	cell	NNS
cord-296347-fanlvxqs	1006	9	transformed	transform	VBN
cord-296347-fanlvxqs	1006	10	by	by	IN
cord-296347-fanlvxqs	1006	11	human	human	JJ
cord-296347-fanlvxqs	1006	12	T	T	NNP
cord-296347-fanlvxqs	1006	13	cell	cell	NN
cord-296347-fanlvxqs	1006	14	leukemia	leukemia	NN
cord-296347-fanlvxqs	1006	15	virus-1	virus-1	NN
cord-296347-fanlvxqs	1006	16	(	(	-LRB-
cord-296347-fanlvxqs	1006	17	HTLV-1	HTLV-1	NNP
cord-296347-fanlvxqs	1006	18	)	)	-RRB-
cord-296347-fanlvxqs	1006	19	.	.	.
cord-296347-fanlvxqs	1007	1	Like	like	IN
cord-296347-fanlvxqs	1007	2	other	other	JJ
cord-296347-fanlvxqs	1007	3	cytokines	cytokine	NNS
cord-296347-fanlvxqs	1007	4	,	,	,
cord-296347-fanlvxqs	1007	5	IL-2	IL-2	NNP
cord-296347-fanlvxqs	1007	6	is	be	VBZ
cord-296347-fanlvxqs	1007	7	an	an	DT
cord-296347-fanlvxqs	1007	8	important	important	JJ
cord-296347-fanlvxqs	1007	9	modulator	modulator	NN
cord-296347-fanlvxqs	1007	10	of	of	IN
cord-296347-fanlvxqs	1007	11	apoptosis	apoptosis	NN
cord-296347-fanlvxqs	1007	12	in	in	IN
cord-296347-fanlvxqs	1007	13	T	t	NN
cord-296347-fanlvxqs	1007	14	cells	cell	NNS
cord-296347-fanlvxqs	1007	15	that	that	WDT
cord-296347-fanlvxqs	1007	16	acts	act	VBZ
cord-296347-fanlvxqs	1007	17	through	through	IN
cord-296347-fanlvxqs	1007	18	the	the	DT
cord-296347-fanlvxqs	1007	19	STAT	stat	NN
cord-296347-fanlvxqs	1007	20	pathway	pathway	NN
cord-296347-fanlvxqs	1007	21	.	.	.
cord-296347-fanlvxqs	1008	1	Although	although	IN
cord-296347-fanlvxqs	1008	2	the	the	DT
cord-296347-fanlvxqs	1008	3	mechanism	mechanism	NN
cord-296347-fanlvxqs	1008	4	is	be	VBZ
cord-296347-fanlvxqs	1008	5	not	not	RB
cord-296347-fanlvxqs	1008	6	at	at	RB
cord-296347-fanlvxqs	1008	7	all	all	RB
cord-296347-fanlvxqs	1008	8	clear	clear	JJ
cord-296347-fanlvxqs	1008	9	,	,	,
cord-296347-fanlvxqs	1008	10	DUB-2	DUB-2	NNP
cord-296347-fanlvxqs	1008	11	activity	activity	NN
cord-296347-fanlvxqs	1008	12	prolongs	prolong	VBZ
cord-296347-fanlvxqs	1008	13	IL-2-stimulated	il-2-stimulate	VBN
cord-296347-fanlvxqs	1008	14	phosphorylation	phosphorylation	NN
cord-296347-fanlvxqs	1008	15	and	and	CC
cord-296347-fanlvxqs	1008	16	transcriptional	transcriptional	JJ
cord-296347-fanlvxqs	1008	17	activity	activity	NN
cord-296347-fanlvxqs	1008	18	of	of	IN
cord-296347-fanlvxqs	1008	19	STAT5	stat5	NN
cord-296347-fanlvxqs	1008	20	,	,	,
cord-296347-fanlvxqs	1008	21	inhibiting	inhibit	VBG
cord-296347-fanlvxqs	1008	22	T	t	NN
cord-296347-fanlvxqs	1008	23	cell	cell	NN
cord-296347-fanlvxqs	1008	24	apoptosis	apoptosis	NN
cord-296347-fanlvxqs	1008	25	in	in	IN
cord-296347-fanlvxqs	1008	26	the	the	DT
cord-296347-fanlvxqs	1008	27	aftermath	aftermath	NN
cord-296347-fanlvxqs	1008	28	of	of	IN
cord-296347-fanlvxqs	1008	29	the	the	DT
cord-296347-fanlvxqs	1008	30	immune	immune	JJ
cord-296347-fanlvxqs	1008	31	response	response	NN
cord-296347-fanlvxqs	1008	32	(	(	-LRB-
cord-296347-fanlvxqs	1009	1	Migone	Migone	NNP
cord-296347-fanlvxqs	1009	2	et	et	NNP
cord-296347-fanlvxqs	1009	3	al	al	NNP
cord-296347-fanlvxqs	1009	4	.	.	.
cord-296347-fanlvxqs	1010	1	,	,	,
cord-296347-fanlvxqs	1010	2	2001	2001	CD
cord-296347-fanlvxqs	1010	3	;	;	:
cord-296347-fanlvxqs	1010	4	Shackelford	Shackelford	NNP
cord-296347-fanlvxqs	1010	5	and	and	CC
cord-296347-fanlvxqs	1010	6	Pagano	Pagano	NNP
cord-296347-fanlvxqs	1010	7	,	,	,
cord-296347-fanlvxqs	1010	8	2004	2004	CD
cord-296347-fanlvxqs	1010	9	)	)	-RRB-
cord-296347-fanlvxqs	1010	10	and	and	CC
cord-296347-fanlvxqs	1010	11	possibly	possibly	RB
cord-296347-fanlvxqs	1010	12	contributing	contribute	VBG
cord-296347-fanlvxqs	1010	13	to	to	IN
cord-296347-fanlvxqs	1010	14	cell	cell	NN
cord-296347-fanlvxqs	1010	15	immortalization	immortalization	NN
cord-296347-fanlvxqs	1010	16	.	.	.
cord-296347-fanlvxqs	1011	1	Cytokine	cytokine	NN
cord-296347-fanlvxqs	1011	2	-	-	HYPH
cord-296347-fanlvxqs	1011	3	inducible	inducible	JJ
cord-296347-fanlvxqs	1011	4	DUBs	dub	NNS
cord-296347-fanlvxqs	1011	5	could	could	MD
cord-296347-fanlvxqs	1011	6	interfere	interfere	VB
cord-296347-fanlvxqs	1011	7	with	with	IN
cord-296347-fanlvxqs	1011	8	cytokine	cytokine	NN
cord-296347-fanlvxqs	1011	9	signaling	signaling	NN
cord-296347-fanlvxqs	1011	10	,	,	,
cord-296347-fanlvxqs	1011	11	thereby	thereby	RB
cord-296347-fanlvxqs	1011	12	playing	play	VBG
cord-296347-fanlvxqs	1011	13	an	an	DT
cord-296347-fanlvxqs	1011	14	active	active	JJ
cord-296347-fanlvxqs	1011	15	role	role	NN
cord-296347-fanlvxqs	1011	16	in	in	IN
cord-296347-fanlvxqs	1011	17	modulation	modulation	NN
cord-296347-fanlvxqs	1011	18	of	of	IN
cord-296347-fanlvxqs	1011	19	the	the	DT
cord-296347-fanlvxqs	1011	20	immune	immune	JJ
cord-296347-fanlvxqs	1011	21	response	response	NN
cord-296347-fanlvxqs	1011	22	.	.	.
cord-296347-fanlvxqs	1012	1	The	the	DT
cord-296347-fanlvxqs	1012	2	IL-1-inducible	il-1-inducible	NN
cord-296347-fanlvxqs	1012	3	DUB-1	dub-1	NN
cord-296347-fanlvxqs	1012	4	is	be	VBZ
cord-296347-fanlvxqs	1012	5	specifically	specifically	RB
cord-296347-fanlvxqs	1012	6	induced	induce	VBN
cord-296347-fanlvxqs	1012	7	by	by	IN
cord-296347-fanlvxqs	1012	8	interleukin	interleukin	NN
cord-296347-fanlvxqs	1012	9	3	3	CD
cord-296347-fanlvxqs	1012	10	(	(	-LRB-
cord-296347-fanlvxqs	1012	11	IL-3	IL-3	NNP
cord-296347-fanlvxqs	1012	12	)	)	-RRB-
cord-296347-fanlvxqs	1012	13	,	,	,
cord-296347-fanlvxqs	1012	14	GM	GM	NNP
cord-296347-fanlvxqs	1012	15	-	-	HYPH
cord-296347-fanlvxqs	1012	16	CSF	CSF	NNP
cord-296347-fanlvxqs	1012	17	,	,	,
cord-296347-fanlvxqs	1012	18	and	and	CC
cord-296347-fanlvxqs	1012	19	IL-5	IL-5	NNP
cord-296347-fanlvxqs	1012	20	,	,	,
cord-296347-fanlvxqs	1012	21	which	which	WDT
cord-296347-fanlvxqs	1012	22	suggests	suggest	VBZ
cord-296347-fanlvxqs	1012	23	a	a	DT
cord-296347-fanlvxqs	1012	24	role	role	NN
cord-296347-fanlvxqs	1012	25	in	in	IN
cord-296347-fanlvxqs	1012	26	responses	response	NNS
cord-296347-fanlvxqs	1012	27	mediated	mediate	VBN
cord-296347-fanlvxqs	1012	28	by	by	IN
cord-296347-fanlvxqs	1012	29	these	these	DT
cord-296347-fanlvxqs	1012	30	cytokines	cytokine	NNS
cord-296347-fanlvxqs	1012	31	(	(	-LRB-
cord-296347-fanlvxqs	1012	32	D'Andrea	D'Andrea	NNP
cord-296347-fanlvxqs	1012	33	and	and	CC
cord-296347-fanlvxqs	1012	34	Pellman	Pellman	NNP
cord-296347-fanlvxqs	1012	35	,	,	,
cord-296347-fanlvxqs	1012	36	1998	1998	CD
cord-296347-fanlvxqs	1012	37	)	)	-RRB-
cord-296347-fanlvxqs	1012	38	and	and	CC
cord-296347-fanlvxqs	1012	39	might	may	MD
cord-296347-fanlvxqs	1012	40	constitute	constitute	VB
cord-296347-fanlvxqs	1012	41	a	a	DT
cord-296347-fanlvxqs	1012	42	target	target	NN
cord-296347-fanlvxqs	1012	43	for	for	IN
cord-296347-fanlvxqs	1012	44	pathogen	pathogen	NN
cord-296347-fanlvxqs	1012	45	modulation	modulation	NN
cord-296347-fanlvxqs	1012	46	of	of	IN
cord-296347-fanlvxqs	1012	47	the	the	DT
cord-296347-fanlvxqs	1012	48	immune	immune	JJ
cord-296347-fanlvxqs	1012	49	response	response	NN
cord-296347-fanlvxqs	1012	50	through	through	IN
cord-296347-fanlvxqs	1012	51	interference	interference	NN
cord-296347-fanlvxqs	1012	52	with	with	IN
cord-296347-fanlvxqs	1012	53	the	the	DT
cord-296347-fanlvxqs	1012	54	Ub	Ub	NNP
cord-296347-fanlvxqs	1012	55	-	-	HYPH
cord-296347-fanlvxqs	1012	56	proteasome	proteasome	NN
cord-296347-fanlvxqs	1012	57	system	system	NN
cord-296347-fanlvxqs	1012	58	.	.	.
cord-296347-fanlvxqs	1013	1	Although	although	IN
cord-296347-fanlvxqs	1013	2	a	a	DT
cord-296347-fanlvxqs	1013	3	review	review	NN
cord-296347-fanlvxqs	1013	4	of	of	IN
cord-296347-fanlvxqs	1013	5	this	this	DT
cord-296347-fanlvxqs	1013	6	rapidly	rapidly	RB
cord-296347-fanlvxqs	1013	7	expanding	expand	VBG
cord-296347-fanlvxqs	1013	8	field	field	NN
cord-296347-fanlvxqs	1013	9	is	be	VBZ
cord-296347-fanlvxqs	1013	10	beyond	beyond	IN
cord-296347-fanlvxqs	1013	11	the	the	DT
cord-296347-fanlvxqs	1013	12	scope	scope	NN
cord-296347-fanlvxqs	1013	13	of	of	IN
cord-296347-fanlvxqs	1013	14	this	this	DT
cord-296347-fanlvxqs	1013	15	chapter	chapter	NN
cord-296347-fanlvxqs	1013	16	,	,	,
cord-296347-fanlvxqs	1013	17	even	even	RB
cord-296347-fanlvxqs	1013	18	this	this	DT
cord-296347-fanlvxqs	1013	19	simple	simple	JJ
cord-296347-fanlvxqs	1013	20	example	example	NN
cord-296347-fanlvxqs	1013	21	suffices	suffice	VBZ
cord-296347-fanlvxqs	1013	22	to	to	TO
cord-296347-fanlvxqs	1013	23	demonstrate	demonstrate	VB
cord-296347-fanlvxqs	1013	24	how	how	WRB
cord-296347-fanlvxqs	1013	25	both	both	CC
cord-296347-fanlvxqs	1013	26	Ub	ub	JJ
cord-296347-fanlvxqs	1013	27	addition	addition	NN
cord-296347-fanlvxqs	1013	28	and	and	CC
cord-296347-fanlvxqs	1013	29	removal	removal	NN
cord-296347-fanlvxqs	1013	30	control	control	NN
cord-296347-fanlvxqs	1013	31	immune	immune	JJ
cord-296347-fanlvxqs	1013	32	physiology	physiology	NN
cord-296347-fanlvxqs	1013	33	,	,	,
cord-296347-fanlvxqs	1013	34	and	and	CC
cord-296347-fanlvxqs	1013	35	consequently	consequently	RB
cord-296347-fanlvxqs	1013	36	are	be	VBP
cord-296347-fanlvxqs	1013	37	likely	likely	JJ
cord-296347-fanlvxqs	1013	38	targets	target	NNS
cord-296347-fanlvxqs	1013	39	for	for	IN
cord-296347-fanlvxqs	1013	40	interference	interference	NN
cord-296347-fanlvxqs	1013	41	by	by	IN
cord-296347-fanlvxqs	1013	42	pathogens	pathogen	NNS
cord-296347-fanlvxqs	1013	43	.	.	.
cord-296347-fanlvxqs	1014	1	Bacteria	Bacteria	NNS
cord-296347-fanlvxqs	1014	2	of	of	IN
cord-296347-fanlvxqs	1014	3	the	the	DT
cord-296347-fanlvxqs	1014	4	Yersinia	Yersinia	NNP
cord-296347-fanlvxqs	1014	5	genus	genus	NN
cord-296347-fanlvxqs	1014	6	are	be	VBP
cord-296347-fanlvxqs	1014	7	the	the	DT
cord-296347-fanlvxqs	1014	8	causal	causal	JJ
cord-296347-fanlvxqs	1014	9	agents	agent	NNS
cord-296347-fanlvxqs	1014	10	of	of	IN
cord-296347-fanlvxqs	1014	11	plague	plague	NN
cord-296347-fanlvxqs	1014	12	,	,	,
cord-296347-fanlvxqs	1014	13	septicemia	septicemia	NN
cord-296347-fanlvxqs	1014	14	,	,	,
cord-296347-fanlvxqs	1014	15	and	and	CC
cord-296347-fanlvxqs	1014	16	gastrointestinal	gastrointestinal	JJ
cord-296347-fanlvxqs	1014	17	syndromes	syndrome	NNS
cord-296347-fanlvxqs	1014	18	.	.	.
cord-296347-fanlvxqs	1015	1	Enteropathogenic	Enteropathogenic	NNP
cord-296347-fanlvxqs	1015	2	Yersinia	Yersinia	NNP
cord-296347-fanlvxqs	1015	3	species	specie	NNS
cord-296347-fanlvxqs	1015	4	are	be	VBP
cord-296347-fanlvxqs	1015	5	extracellular	extracellular	JJ
cord-296347-fanlvxqs	1015	6	multiplying	multiply	VBG
cord-296347-fanlvxqs	1015	7	Gram	gram	NN
cord-296347-fanlvxqs	1015	8	-	-	HYPH
cord-296347-fanlvxqs	1015	9	negative	negative	JJ
cord-296347-fanlvxqs	1015	10	bacteria	bacteria	NNS
cord-296347-fanlvxqs	1015	11	that	that	WDT
cord-296347-fanlvxqs	1015	12	make	make	VBP
cord-296347-fanlvxqs	1015	13	use	use	NN
cord-296347-fanlvxqs	1015	14	of	of	IN
cord-296347-fanlvxqs	1015	15	type	type	NN
cord-296347-fanlvxqs	1015	16	III	iii	CD
cord-296347-fanlvxqs	1015	17	secretion	secretion	NN
cord-296347-fanlvxqs	1015	18	systems	system	NNS
cord-296347-fanlvxqs	1015	19	to	to	TO
cord-296347-fanlvxqs	1015	20	inject	inject	VB
cord-296347-fanlvxqs	1015	21	virulence	virulence	NN
cord-296347-fanlvxqs	1015	22	factors	factor	NNS
cord-296347-fanlvxqs	1015	23	into	into	IN
cord-296347-fanlvxqs	1015	24	host	host	NN
cord-296347-fanlvxqs	1015	25	cells	cell	NNS
cord-296347-fanlvxqs	1015	26	.	.	.
cord-296347-fanlvxqs	1016	1	The	the	DT
cord-296347-fanlvxqs	1016	2	Yersinia	Yersinia	NNP
cord-296347-fanlvxqs	1016	3	YopJ	YopJ	NNP
cord-296347-fanlvxqs	1016	4	virulence	virulence	NN
cord-296347-fanlvxqs	1016	5	factor	factor	NN
cord-296347-fanlvxqs	1016	6	encodes	encode	VBZ
cord-296347-fanlvxqs	1016	7	a	a	DT
cord-296347-fanlvxqs	1016	8	protein	protein	NN
cord-296347-fanlvxqs	1016	9	reported	report	VBN
cord-296347-fanlvxqs	1016	10	to	to	TO
cord-296347-fanlvxqs	1016	11	be	be	VB
cord-296347-fanlvxqs	1016	12	a	a	DT
cord-296347-fanlvxqs	1016	13	cysteine	cysteine	NN
cord-296347-fanlvxqs	1016	14	protease	protease	NN
cord-296347-fanlvxqs	1016	15	that	that	WDT
cord-296347-fanlvxqs	1016	16	can	can	MD
cord-296347-fanlvxqs	1016	17	cleave	cleave	VB
cord-296347-fanlvxqs	1016	18	Ub	Ub	NNP
cord-296347-fanlvxqs	1016	19	and	and	CC
cord-296347-fanlvxqs	1016	20	SUMO	SUMO	NNP
cord-296347-fanlvxqs	1016	21	.	.	.
cord-296347-fanlvxqs	1017	1	The	the	DT
cord-296347-fanlvxqs	1017	2	YopJ	YopJ	NNP
cord-296347-fanlvxqs	1017	3	DUB	DUB	NNP
cord-296347-fanlvxqs	1017	4	inhibits	inhibit	VBZ
cord-296347-fanlvxqs	1017	5	NF	nf	NN
cord-296347-fanlvxqs	1017	6	-	-	HYPH
cord-296347-fanlvxqs	1017	7	kB	kB	NNP
cord-296347-fanlvxqs	1017	8	and	and	CC
cord-296347-fanlvxqs	1017	9	mitogen	mitogen	NNP
cord-296347-fanlvxqs	1017	10	-	-	HYPH
cord-296347-fanlvxqs	1017	11	activated	activate	VBN
cord-296347-fanlvxqs	1018	1	protein	protein	NN
cord-296347-fanlvxqs	1018	2	kinase	kinase	NNP
cord-296347-fanlvxqs	1018	3	(	(	-LRB-
cord-296347-fanlvxqs	1018	4	MAPK	MAPK	NNP
cord-296347-fanlvxqs	1018	5	)	)	-RRB-
cord-296347-fanlvxqs	1018	6	pathways	pathway	NNS
cord-296347-fanlvxqs	1018	7	,	,	,
cord-296347-fanlvxqs	1018	8	a	a	DT
cord-296347-fanlvxqs	1018	9	function	function	NN
cord-296347-fanlvxqs	1018	10	ascribed	ascribe	VBN
cord-296347-fanlvxqs	1018	11	previously	previously	RB
cord-296347-fanlvxqs	1018	12	to	to	IN
cord-296347-fanlvxqs	1018	13	its	-PRON-	PRP$
cord-296347-fanlvxqs	1018	14	somewhat	somewhat	RB
cord-296347-fanlvxqs	1018	15	promiscuous	promiscuous	JJ
cord-296347-fanlvxqs	1018	16	deubiquitination	deubiquitination	NN
cord-296347-fanlvxqs	1018	17	of	of	IN
cord-296347-fanlvxqs	1018	18	critical	critical	JJ
cord-296347-fanlvxqs	1018	19	cellular	cellular	JJ
cord-296347-fanlvxqs	1018	20	proteins	protein	NNS
cord-296347-fanlvxqs	1018	21	,	,	,
cord-296347-fanlvxqs	1018	22	such	such	JJ
cord-296347-fanlvxqs	1018	23	as	as	IN
cord-296347-fanlvxqs	1018	24	TRAF2	TRAF2	NNP
cord-296347-fanlvxqs	1018	25	,	,	,
cord-296347-fanlvxqs	1018	26	TRAF6	TRAF6	NNP
cord-296347-fanlvxqs	1018	27	,	,	,
cord-296347-fanlvxqs	1018	28	and	and	CC
cord-296347-fanlvxqs	1018	29	IkB.	IkB.	NNP
cord-296347-fanlvxqs	1019	1	The	the	DT
cord-296347-fanlvxqs	1019	2	MAPK	MAPK	NNP
cord-296347-fanlvxqs	1019	3	/	/	SYM
cord-296347-fanlvxqs	1019	4	JUN	JUN	NNP
cord-296347-fanlvxqs	1019	5	pathway	pathway	NN
cord-296347-fanlvxqs	1019	6	is	be	VBZ
cord-296347-fanlvxqs	1019	7	involved	involve	VBN
cord-296347-fanlvxqs	1019	8	in	in	IN
cord-296347-fanlvxqs	1019	9	transcriptional	transcriptional	JJ
cord-296347-fanlvxqs	1019	10	control	control	NN
cord-296347-fanlvxqs	1019	11	of	of	IN
cord-296347-fanlvxqs	1019	12	several	several	JJ
cord-296347-fanlvxqs	1019	13	cytokine	cytokine	NN
cord-296347-fanlvxqs	1019	14	genes	gene	NNS
cord-296347-fanlvxqs	1019	15	.	.	.
cord-296347-fanlvxqs	1020	1	The	the	DT
cord-296347-fanlvxqs	1020	2	YopJ	YopJ	NNP
cord-296347-fanlvxqs	1020	3	activity	activity	NN
cord-296347-fanlvxqs	1020	4	induces	induce	VBZ
cord-296347-fanlvxqs	1020	5	macrophage	macrophage	NN
cord-296347-fanlvxqs	1020	6	death	death	NN
cord-296347-fanlvxqs	1020	7	and	and	CC
cord-296347-fanlvxqs	1020	8	blocks	block	VBZ
cord-296347-fanlvxqs	1020	9	their	-PRON-	PRP$
cord-296347-fanlvxqs	1020	10	ability	ability	NN
cord-296347-fanlvxqs	1020	11	to	to	TO
cord-296347-fanlvxqs	1020	12	activate	activate	VB
cord-296347-fanlvxqs	1020	13	these	these	DT
cord-296347-fanlvxqs	1020	14	inflammatory	inflammatory	JJ
cord-296347-fanlvxqs	1020	15	pathways	pathway	NNS
cord-296347-fanlvxqs	1020	16	(	(	-LRB-
cord-296347-fanlvxqs	1020	17	Orth	Orth	NNP
cord-296347-fanlvxqs	1020	18	,	,	,
cord-296347-fanlvxqs	1020	19	2002	2002	CD
cord-296347-fanlvxqs	1020	20	;	;	:
cord-296347-fanlvxqs	1020	21	Orth	Orth	NNP
cord-296347-fanlvxqs	1020	22	et	et	NNP
cord-296347-fanlvxqs	1020	23	al	al	NNP
cord-296347-fanlvxqs	1020	24	.	.	NNP
cord-296347-fanlvxqs	1020	25	,	,	,
cord-296347-fanlvxqs	1020	26	2000	2000	CD
cord-296347-fanlvxqs	1020	27	;	;	:
cord-296347-fanlvxqs	1020	28	Zhou	Zhou	NNP
cord-296347-fanlvxqs	1020	29	et	et	NNP
cord-296347-fanlvxqs	1020	30	al	al	NNP
cord-296347-fanlvxqs	1020	31	.	.	NNP
cord-296347-fanlvxqs	1020	32	,	,	,
cord-296347-fanlvxqs	1020	33	2005	2005	CD
cord-296347-fanlvxqs	1020	34	)	)	-RRB-
cord-296347-fanlvxqs	1020	35	.	.	.
cord-296347-fanlvxqs	1021	1	However	however	RB
cord-296347-fanlvxqs	1021	2	,	,	,
cord-296347-fanlvxqs	1021	3	recent	recent	JJ
cord-296347-fanlvxqs	1021	4	reports	report	NNS
cord-296347-fanlvxqs	1021	5	show	show	VBP
cord-296347-fanlvxqs	1021	6	that	that	IN
cord-296347-fanlvxqs	1021	7	the	the	DT
cord-296347-fanlvxqs	1021	8	true	true	JJ
cord-296347-fanlvxqs	1021	9	function	function	NN
cord-296347-fanlvxqs	1021	10	of	of	IN
cord-296347-fanlvxqs	1021	11	YopJ	YopJ	NNP
cord-296347-fanlvxqs	1021	12	is	be	VBZ
cord-296347-fanlvxqs	1021	13	that	that	DT
cord-296347-fanlvxqs	1021	14	of	of	IN
cord-296347-fanlvxqs	1021	15	a	a	DT
cord-296347-fanlvxqs	1021	16	serine	serine	NN
cord-296347-fanlvxqs	1021	17	/	/	SYM
cord-296347-fanlvxqs	1021	18	threonine	threonine	NN
cord-296347-fanlvxqs	1021	19	acetyltransferase	acetyltransferase	NN
cord-296347-fanlvxqs	1021	20	(	(	-LRB-
cord-296347-fanlvxqs	1021	21	Mukherjee	Mukherjee	NNP
cord-296347-fanlvxqs	1021	22	et	et	NNP
cord-296347-fanlvxqs	1021	23	al	al	NNP
cord-296347-fanlvxqs	1021	24	.	.	NNP
cord-296347-fanlvxqs	1021	25	,	,	,
cord-296347-fanlvxqs	1021	26	2006	2006	CD
cord-296347-fanlvxqs	1021	27	)	)	-RRB-
cord-296347-fanlvxqs	1021	28	.	.	.
cord-296347-fanlvxqs	1022	1	The	the	DT
cord-296347-fanlvxqs	1022	2	way	way	NN
cord-296347-fanlvxqs	1022	3	by	by	IN
cord-296347-fanlvxqs	1022	4	which	which	WDT
cord-296347-fanlvxqs	1022	5	the	the	DT
cord-296347-fanlvxqs	1022	6	functions	function	NNS
cord-296347-fanlvxqs	1022	7	assigned	assign	VBN
cord-296347-fanlvxqs	1022	8	to	to	IN
cord-296347-fanlvxqs	1022	9	YopJ	YopJ	NNP
cord-296347-fanlvxqs	1022	10	have	have	VB
cord-296347-fanlvxqs	1022	11	changed	change	VBN
cord-296347-fanlvxqs	1022	12	as	as	IN
cord-296347-fanlvxqs	1022	13	the	the	DT
cord-296347-fanlvxqs	1022	14	field	field	NN
cord-296347-fanlvxqs	1022	15	advances	advance	VBZ
cord-296347-fanlvxqs	1022	16	demonstrates	demonstrate	VBZ
cord-296347-fanlvxqs	1022	17	the	the	DT
cord-296347-fanlvxqs	1022	18	complexity	complexity	NN
cord-296347-fanlvxqs	1022	19	of	of	IN
cord-296347-fanlvxqs	1022	20	assigning	assign	VBG
cord-296347-fanlvxqs	1022	21	a	a	DT
cord-296347-fanlvxqs	1022	22	function	function	NN
cord-296347-fanlvxqs	1022	23	to	to	IN
cord-296347-fanlvxqs	1022	24	proteins	protein	NNS
cord-296347-fanlvxqs	1022	25	that	that	WDT
cord-296347-fanlvxqs	1022	26	lack	lack	VBP
cord-296347-fanlvxqs	1022	27	obvious	obvious	JJ
cord-296347-fanlvxqs	1022	28	mammalian	mammalian	JJ
cord-296347-fanlvxqs	1022	29	counterparts	counterpart	NNS
cord-296347-fanlvxqs	1022	30	.	.	.
cord-296347-fanlvxqs	1023	1	Both	both	DT
cord-296347-fanlvxqs	1023	2	Salmonella	Salmonella	NNP
cord-296347-fanlvxqs	1023	3	and	and	CC
cord-296347-fanlvxqs	1023	4	the	the	DT
cord-296347-fanlvxqs	1023	5	plant	plant	NN
cord-296347-fanlvxqs	1023	6	pathogen	pathogen	NN
cord-296347-fanlvxqs	1023	7	Xanthomonas	Xanthomonas	NNP
cord-296347-fanlvxqs	1023	8	secrete	secrete	VBP
cord-296347-fanlvxqs	1023	9	proteins	protein	NNS
cord-296347-fanlvxqs	1023	10	with	with	IN
cord-296347-fanlvxqs	1023	11	homology	homology	NN
cord-296347-fanlvxqs	1023	12	to	to	IN
cord-296347-fanlvxqs	1023	13	YopJ	YopJ	NNP
cord-296347-fanlvxqs	1023	14	,	,	,
cord-296347-fanlvxqs	1023	15	but	but	CC
cord-296347-fanlvxqs	1023	16	their	-PRON-	PRP$
cord-296347-fanlvxqs	1023	17	putative	putative	JJ
cord-296347-fanlvxqs	1023	18	DUB	dub	NN
cord-296347-fanlvxqs	1023	19	activity	activity	NN
cord-296347-fanlvxqs	1023	20	or	or	CC
cord-296347-fanlvxqs	1023	21	function	function	NN
cord-296347-fanlvxqs	1023	22	in	in	IN
cord-296347-fanlvxqs	1023	23	the	the	DT
cord-296347-fanlvxqs	1023	24	host	host	NN
cord-296347-fanlvxqs	1023	25	have	have	VBP
cord-296347-fanlvxqs	1023	26	not	not	RB
cord-296347-fanlvxqs	1023	27	been	be	VBN
cord-296347-fanlvxqs	1023	28	assessed	assess	VBN
cord-296347-fanlvxqs	1023	29	yet	yet	RB
cord-296347-fanlvxqs	1024	1	(	(	-LRB-
cord-296347-fanlvxqs	1024	2	Gurlebeck	Gurlebeck	NNP
cord-296347-fanlvxqs	1024	3	et	et	FW
cord-296347-fanlvxqs	1024	4	al	al	NNP
cord-296347-fanlvxqs	1024	5	.	.	NNP
cord-296347-fanlvxqs	1024	6	,	,	,
cord-296347-fanlvxqs	1024	7	2006	2006	CD
cord-296347-fanlvxqs	1024	8	;	;	:
cord-296347-fanlvxqs	1024	9	Hardt	Hardt	NNP
cord-296347-fanlvxqs	1024	10	and	and	CC
cord-296347-fanlvxqs	1024	11	Galan	Galan	NNP
cord-296347-fanlvxqs	1024	12	,	,	,
cord-296347-fanlvxqs	1024	13	1997	1997	CD
cord-296347-fanlvxqs	1024	14	)	)	-RRB-
cord-296347-fanlvxqs	1024	15	.	.	.
cord-296347-fanlvxqs	1025	1	A	a	DT
cord-296347-fanlvxqs	1025	2	novel	novel	JJ
cord-296347-fanlvxqs	1025	3	viral	viral	JJ
cord-296347-fanlvxqs	1025	4	USP	USP	NNP
cord-296347-fanlvxqs	1025	5	or	or	CC
cord-296347-fanlvxqs	1025	6	deubiquitinating	deubiquitinating	NN
cord-296347-fanlvxqs	1025	7	enzyme	enzyme	NN
cord-296347-fanlvxqs	1025	8	,	,	,
cord-296347-fanlvxqs	1025	9	UL36	UL36	NNP
cord-296347-fanlvxqs	1025	10	USP	USP	NNP
cord-296347-fanlvxqs	1025	11	,	,	,
cord-296347-fanlvxqs	1025	12	was	be	VBD
cord-296347-fanlvxqs	1025	13	recently	recently	RB
cord-296347-fanlvxqs	1025	14	identified	identify	VBN
cord-296347-fanlvxqs	1025	15	in	in	IN
cord-296347-fanlvxqs	1025	16	herpes	herpes	NN
cord-296347-fanlvxqs	1025	17	simplex	simplex	NN
cord-296347-fanlvxqs	1025	18	virus-1	virus-1	NN
cord-296347-fanlvxqs	1025	19	(	(	-LRB-
cord-296347-fanlvxqs	1025	20	HSV-1	hsv-1	NN
cord-296347-fanlvxqs	1025	21	)	)	-RRB-
cord-296347-fanlvxqs	1025	22	by	by	IN
cord-296347-fanlvxqs	1025	23	labeling	label	VBG
cord-296347-fanlvxqs	1025	24	with	with	IN
cord-296347-fanlvxqs	1025	25	an	an	DT
cord-296347-fanlvxqs	1025	26	Ub	Ub	NNP
cord-296347-fanlvxqs	1025	27	-	-	HYPH
cord-296347-fanlvxqs	1025	28	derived	derive	VBN
cord-296347-fanlvxqs	1025	29	probe	probe	NN
cord-296347-fanlvxqs	1025	30	.	.	.
cord-296347-fanlvxqs	1026	1	The	the	DT
cord-296347-fanlvxqs	1026	2	UL36	UL36	NNP
cord-296347-fanlvxqs	1026	3	USP	USP	NNP
cord-296347-fanlvxqs	1026	4	is	be	VBZ
cord-296347-fanlvxqs	1026	5	located	locate	VBN
cord-296347-fanlvxqs	1026	6	at	at	IN
cord-296347-fanlvxqs	1026	7	the	the	DT
cord-296347-fanlvxqs	1026	8	N	n	CD
cord-296347-fanlvxqs	1026	9	-	-	HYPH
cord-296347-fanlvxqs	1026	10	terminus	terminus	NN
cord-296347-fanlvxqs	1026	11	of	of	IN
cord-296347-fanlvxqs	1026	12	the	the	DT
cord-296347-fanlvxqs	1026	13	UL36	UL36	NNP
cord-296347-fanlvxqs	1026	14	,	,	,
cord-296347-fanlvxqs	1026	15	the	the	DT
cord-296347-fanlvxqs	1026	16	large	large	JJ
cord-296347-fanlvxqs	1026	17	tegument	tegument	NN
cord-296347-fanlvxqs	1026	18	protein	protein	NN
cord-296347-fanlvxqs	1026	19	of	of	IN
cord-296347-fanlvxqs	1026	20	HSV-1	HSV-1	NNP
cord-296347-fanlvxqs	1026	21	,	,	,
cord-296347-fanlvxqs	1026	22	an	an	DT
cord-296347-fanlvxqs	1026	23	a	a	DT
cord-296347-fanlvxqs	1026	24	-	-	HYPH
cord-296347-fanlvxqs	1026	25	herpesvirus	herpesvirus	NN
cord-296347-fanlvxqs	1026	26	.	.	.
cord-296347-fanlvxqs	1027	1	Despite	despite	IN
cord-296347-fanlvxqs	1027	2	the	the	DT
cord-296347-fanlvxqs	1027	3	overall	overall	JJ
cord-296347-fanlvxqs	1027	4	low	low	JJ
cord-296347-fanlvxqs	1027	5	sequence	sequence	NN
cord-296347-fanlvxqs	1027	6	homology	homology	NN
cord-296347-fanlvxqs	1027	7	-	-	:
cord-296347-fanlvxqs	1027	8	at	at	IN
cord-296347-fanlvxqs	1027	9	the	the	DT
cord-296347-fanlvxqs	1027	10	exception	exception	NN
cord-296347-fanlvxqs	1027	11	of	of	IN
cord-296347-fanlvxqs	1027	12	almost	almost	RB
cord-296347-fanlvxqs	1027	13	only	only	RB
cord-296347-fanlvxqs	1027	14	the	the	DT
cord-296347-fanlvxqs	1027	15	amino	amino	NN
cord-296347-fanlvxqs	1027	16	acid	acid	NN
cord-296347-fanlvxqs	1027	17	residues	residue	NNS
cord-296347-fanlvxqs	1027	18	composing	compose	VBG
cord-296347-fanlvxqs	1027	19	the	the	DT
cord-296347-fanlvxqs	1027	20	catalytic	catalytic	JJ
cord-296347-fanlvxqs	1027	21	triad	triad	NN
cord-296347-fanlvxqs	1027	22	-	-	:
cord-296347-fanlvxqs	1027	23	the	the	DT
cord-296347-fanlvxqs	1027	24	UL36	UL36	NNP
cord-296347-fanlvxqs	1027	25	USP	USP	NNP
cord-296347-fanlvxqs	1027	26	activity	activity	NN
cord-296347-fanlvxqs	1027	27	is	be	VBZ
cord-296347-fanlvxqs	1027	28	well	well	RB
cord-296347-fanlvxqs	1027	29	conserved	conserve	VBN
cord-296347-fanlvxqs	1027	30	in	in	IN
cord-296347-fanlvxqs	1027	31	all	all	DT
cord-296347-fanlvxqs	1027	32	members	member	NNS
cord-296347-fanlvxqs	1027	33	of	of	IN
cord-296347-fanlvxqs	1027	34	the	the	DT
cord-296347-fanlvxqs	1027	35	Herpesviridae	Herpesviridae	NNP
cord-296347-fanlvxqs	1027	36	family	family	NN
cord-296347-fanlvxqs	1027	37	,	,	,
cord-296347-fanlvxqs	1027	38	as	as	IN
cord-296347-fanlvxqs	1027	39	the	the	DT
cord-296347-fanlvxqs	1027	40	homologous	homologous	JJ
cord-296347-fanlvxqs	1027	41	proteins	protein	NNS
cord-296347-fanlvxqs	1027	42	in	in	IN
cord-296347-fanlvxqs	1027	43	murine	murine	JJ
cord-296347-fanlvxqs	1027	44	cytomegalovirus	cytomegalovirus	NN
cord-296347-fanlvxqs	1027	45	(	(	-LRB-
cord-296347-fanlvxqs	1027	46	a	a	DT
cord-296347-fanlvxqs	1027	47	b	b	NN
cord-296347-fanlvxqs	1027	48	-	-	HYPH
cord-296347-fanlvxqs	1027	49	herpesvirus	herpesvirus	NN
cord-296347-fanlvxqs	1027	50	)	)	-RRB-
cord-296347-fanlvxqs	1027	51	and	and	CC
cord-296347-fanlvxqs	1027	52	EBV	EBV	NNP
cord-296347-fanlvxqs	1027	53	(	(	-LRB-
cord-296347-fanlvxqs	1027	54	a	a	DT
cord-296347-fanlvxqs	1027	55	g	g	NN
cord-296347-fanlvxqs	1027	56	-	-	HYPH
cord-296347-fanlvxqs	1027	57	herpesvirus	herpesvirus	NN
cord-296347-fanlvxqs	1027	58	)	)	-RRB-
cord-296347-fanlvxqs	1027	59	also	also	RB
cord-296347-fanlvxqs	1027	60	exhibit	exhibit	VBP
cord-296347-fanlvxqs	1027	61	DUB	dub	NN
cord-296347-fanlvxqs	1027	62	activity	activity	NN
cord-296347-fanlvxqs	1027	63	in	in	IN
cord-296347-fanlvxqs	1027	64	vitro	vitro	FW
cord-296347-fanlvxqs	1028	1	(	(	-LRB-
cord-296347-fanlvxqs	1028	2	Schlieker	Schlieker	NNP
cord-296347-fanlvxqs	1028	3	et	et	NNP
cord-296347-fanlvxqs	1028	4	al	al	NNP
cord-296347-fanlvxqs	1028	5	.	.	NNP
cord-296347-fanlvxqs	1028	6	,	,	,
cord-296347-fanlvxqs	1028	7	2005	2005	CD
cord-296347-fanlvxqs	1028	8	)	)	-RRB-
cord-296347-fanlvxqs	1028	9	.	.	.
cord-296347-fanlvxqs	1029	1	One	one	CD
cord-296347-fanlvxqs	1029	2	of	of	IN
cord-296347-fanlvxqs	1029	3	the	the	DT
cord-296347-fanlvxqs	1029	4	two	two	CD
cord-296347-fanlvxqs	1029	5	severe	severe	JJ
cord-296347-fanlvxqs	1029	6	acute	acute	JJ
cord-296347-fanlvxqs	1029	7	respiratory	respiratory	JJ
cord-296347-fanlvxqs	1029	8	syndrome	syndrome	NN
cord-296347-fanlvxqs	1029	9	(	(	-LRB-
cord-296347-fanlvxqs	1029	10	SARS	SARS	NNP
cord-296347-fanlvxqs	1029	11	)	)	-RRB-
cord-296347-fanlvxqs	1030	1	Coronavirus	Coronavirus	NNP
cord-296347-fanlvxqs	1030	2	proteases	protease	NNS
cord-296347-fanlvxqs	1030	3	responsible	responsible	JJ
cord-296347-fanlvxqs	1030	4	for	for	IN
cord-296347-fanlvxqs	1030	5	cleavage	cleavage	NN
cord-296347-fanlvxqs	1030	6	of	of	IN
cord-296347-fanlvxqs	1030	7	the	the	DT
cord-296347-fanlvxqs	1030	8	replicase	replicase	NNP
cord-296347-fanlvxqs	1030	9	polyprotein	polyprotein	NNP
cord-296347-fanlvxqs	1030	10	,	,	,
cord-296347-fanlvxqs	1030	11	the	the	DT
cord-296347-fanlvxqs	1030	12	SARS	SARS	NNP
cord-296347-fanlvxqs	1030	13	-	-	HYPH
cord-296347-fanlvxqs	1030	14	CoV	CoV	NNP
cord-296347-fanlvxqs	1030	15	papain	papain	NN
cord-296347-fanlvxqs	1030	16	-	-	HYPH
cord-296347-fanlvxqs	1030	17	like	like	JJ
cord-296347-fanlvxqs	1030	18	protease	protease	NN
cord-296347-fanlvxqs	1030	19	PLpro	PLpro	NNP
cord-296347-fanlvxqs	1030	20	,	,	,
cord-296347-fanlvxqs	1030	21	is	be	VBZ
cord-296347-fanlvxqs	1030	22	also	also	RB
cord-296347-fanlvxqs	1030	23	a	a	DT
cord-296347-fanlvxqs	1030	24	DUB	dub	NN
cord-296347-fanlvxqs	1030	25	(	(	-LRB-
cord-296347-fanlvxqs	1030	26	Barretto	Barretto	NNP
cord-296347-fanlvxqs	1030	27	et	et	NNP
cord-296347-fanlvxqs	1030	28	al	al	NNP
cord-296347-fanlvxqs	1030	29	.	.	NNP
cord-296347-fanlvxqs	1030	30	,	,	,
cord-296347-fanlvxqs	1030	31	2005	2005	CD
cord-296347-fanlvxqs	1030	32	;	;	:
cord-296347-fanlvxqs	1031	1	Lindner	Lindner	NNP
cord-296347-fanlvxqs	1031	2	et	et	NNP
cord-296347-fanlvxqs	1031	3	al	al	NNP
cord-296347-fanlvxqs	1031	4	.	.	NNP
cord-296347-fanlvxqs	1031	5	,	,	,
cord-296347-fanlvxqs	1031	6	2005	2005	CD
cord-296347-fanlvxqs	1031	7	)	)	-RRB-
cord-296347-fanlvxqs	1031	8	,	,	,
cord-296347-fanlvxqs	1031	9	predicted	predict	VBD
cord-296347-fanlvxqs	1031	10	to	to	TO
cord-296347-fanlvxqs	1031	11	be	be	VB
cord-296347-fanlvxqs	1031	12	structurally	structurally	RB
cord-296347-fanlvxqs	1031	13	similar	similar	JJ
cord-296347-fanlvxqs	1031	14	to	to	IN
cord-296347-fanlvxqs	1031	15	human	human	JJ
cord-296347-fanlvxqs	1031	16	USP7	USP7	NNP
cord-296347-fanlvxqs	1032	1	(	(	-LRB-
cord-296347-fanlvxqs	1032	2	Hu	Hu	NNP
cord-296347-fanlvxqs	1032	3	et	et	FW
cord-296347-fanlvxqs	1032	4	al	al	NNP
cord-296347-fanlvxqs	1032	5	.	.	NNP
cord-296347-fanlvxqs	1032	6	,	,	,
cord-296347-fanlvxqs	1032	7	2002	2002	CD
cord-296347-fanlvxqs	1032	8	)	)	-RRB-
cord-296347-fanlvxqs	1032	9	.	.	.
cord-296347-fanlvxqs	1033	1	The	the	DT
cord-296347-fanlvxqs	1033	2	SARS	SARS	NNP
cord-296347-fanlvxqs	1033	3	-	-	HYPH
cord-296347-fanlvxqs	1033	4	CoV	cov	NN
cord-296347-fanlvxqs	1033	5	Plpro	Plpro	NNP
cord-296347-fanlvxqs	1033	6	protease	protease	NN
cord-296347-fanlvxqs	1033	7	activity	activity	NN
cord-296347-fanlvxqs	1033	8	is	be	VBZ
cord-296347-fanlvxqs	1033	9	involved	involve	VBN
cord-296347-fanlvxqs	1033	10	in	in	IN
cord-296347-fanlvxqs	1033	11	the	the	DT
cord-296347-fanlvxqs	1033	12	processing	processing	NN
cord-296347-fanlvxqs	1033	13	of	of	IN
cord-296347-fanlvxqs	1033	14	the	the	DT
cord-296347-fanlvxqs	1033	15	viral	viral	JJ
cord-296347-fanlvxqs	1033	16	polyprotein	polyprotein	NN
cord-296347-fanlvxqs	1033	17	,	,	,
cord-296347-fanlvxqs	1033	18	thereby	thereby	RB
cord-296347-fanlvxqs	1033	19	contributing	contribute	VBG
cord-296347-fanlvxqs	1033	20	to	to	IN
cord-296347-fanlvxqs	1033	21	replication	replication	NN
cord-296347-fanlvxqs	1033	22	of	of	IN
cord-296347-fanlvxqs	1033	23	the	the	DT
cord-296347-fanlvxqs	1033	24	viral	viral	JJ
cord-296347-fanlvxqs	1033	25	RNA	RNA	NNP
cord-296347-fanlvxqs	1033	26	genome	genome	NN
cord-296347-fanlvxqs	1033	27	.	.	.
cord-296347-fanlvxqs	1034	1	The	the	DT
cord-296347-fanlvxqs	1034	2	function	function	NN
cord-296347-fanlvxqs	1034	3	of	of	IN
cord-296347-fanlvxqs	1034	4	the	the	DT
cord-296347-fanlvxqs	1034	5	SARS	SARS	NNP
cord-296347-fanlvxqs	1034	6	virus	virus	NN
cord-296347-fanlvxqs	1034	7	deubiquitinating	deubiquitinating	NN
cord-296347-fanlvxqs	1034	8	activity	activity	NN
cord-296347-fanlvxqs	1034	9	,	,	,
cord-296347-fanlvxqs	1034	10	which	which	WDT
cord-296347-fanlvxqs	1034	11	extends	extend	VBZ
cord-296347-fanlvxqs	1034	12	to	to	IN
cord-296347-fanlvxqs	1034	13	ISG15-removal	ISG15-removal	NNP
cord-296347-fanlvxqs	1034	14	activity	activity	NN
cord-296347-fanlvxqs	1034	15	(	(	-LRB-
cord-296347-fanlvxqs	1034	16	Lindner	Lindner	NNP
cord-296347-fanlvxqs	1034	17	et	et	NNP
cord-296347-fanlvxqs	1034	18	al	al	NNP
cord-296347-fanlvxqs	1034	19	.	.	NNP
cord-296347-fanlvxqs	1034	20	,	,	,
cord-296347-fanlvxqs	1034	21	2005	2005	CD
cord-296347-fanlvxqs	1034	22	)	)	-RRB-
cord-296347-fanlvxqs	1034	23	,	,	,
cord-296347-fanlvxqs	1034	24	is	be	VBZ
cord-296347-fanlvxqs	1034	25	unknown	unknown	JJ
cord-296347-fanlvxqs	1034	26	at	at	IN
cord-296347-fanlvxqs	1034	27	this	this	DT
cord-296347-fanlvxqs	1034	28	point	point	NN
cord-296347-fanlvxqs	1034	29	.	.	.
cord-296347-fanlvxqs	1035	1	The	the	DT
cord-296347-fanlvxqs	1035	2	adenovirus	adenovirus	NN
cord-296347-fanlvxqs	1035	3	proteinase	proteinase	NN
cord-296347-fanlvxqs	1035	4	(	(	-LRB-
cord-296347-fanlvxqs	1035	5	Avp	Avp	NNP
cord-296347-fanlvxqs	1035	6	)	)	-RRB-
cord-296347-fanlvxqs	1035	7	and	and	CC
cord-296347-fanlvxqs	1035	8	the	the	DT
cord-296347-fanlvxqs	1035	9	human	human	JJ
cord-296347-fanlvxqs	1035	10	cytomegalovirus	cytomegalovirus	NN
cord-296347-fanlvxqs	1035	11	UL48	UL48	NNP
cord-296347-fanlvxqs	1035	12	protein	protein	NN
cord-296347-fanlvxqs	1035	13	also	also	RB
cord-296347-fanlvxqs	1035	14	encode	encode	VBP
cord-296347-fanlvxqs	1035	15	DUB	dub	NN
cord-296347-fanlvxqs	1035	16	activities	activity	NNS
cord-296347-fanlvxqs	1035	17	,	,	,
cord-296347-fanlvxqs	1035	18	but	but	CC
cord-296347-fanlvxqs	1035	19	the	the	DT
cord-296347-fanlvxqs	1035	20	viral	viral	JJ
cord-296347-fanlvxqs	1035	21	and/or	and/or	CC
cord-296347-fanlvxqs	1035	22	cellular	cellular	JJ
cord-296347-fanlvxqs	1035	23	targets	target	NNS
cord-296347-fanlvxqs	1035	24	remain	remain	VBP
cord-296347-fanlvxqs	1035	25	unidentified	unidentified	JJ
cord-296347-fanlvxqs	1036	1	(	(	-LRB-
cord-296347-fanlvxqs	1036	2	Balakirev	Balakirev	NNP
cord-296347-fanlvxqs	1036	3	et	et	NNP
cord-296347-fanlvxqs	1036	4	al	al	NNP
cord-296347-fanlvxqs	1036	5	.	.	NNP
cord-296347-fanlvxqs	1036	6	,	,	,
cord-296347-fanlvxqs	1036	7	2002	2002	CD
cord-296347-fanlvxqs	1036	8	;	;	:
cord-296347-fanlvxqs	1036	9	Wang	Wang	NNP
cord-296347-fanlvxqs	1036	10	et	et	NNP
cord-296347-fanlvxqs	1036	11	al	al	NNP
cord-296347-fanlvxqs	1036	12	.	.	.
cord-296347-fanlvxqs	1037	1	,	,	,
cord-296347-fanlvxqs	1037	2	2006b	2006b	CD
cord-296347-fanlvxqs	1037	3	)	)	-RRB-
cord-296347-fanlvxqs	1037	4	.	.	.
cord-296347-fanlvxqs	1038	1	Chlamydia	Chlamydia	NNP
cord-296347-fanlvxqs	1038	2	trachomatis	trachomatis	NN
cord-296347-fanlvxqs	1038	3	,	,	,
cord-296347-fanlvxqs	1038	4	an	an	DT
cord-296347-fanlvxqs	1038	5	obligate	obligate	JJ
cord-296347-fanlvxqs	1038	6	intracellular	intracellular	JJ
cord-296347-fanlvxqs	1038	7	bacterium	bacterium	NN
cord-296347-fanlvxqs	1038	8	that	that	WDT
cord-296347-fanlvxqs	1038	9	causes	cause	VBZ
cord-296347-fanlvxqs	1038	10	a	a	DT
cord-296347-fanlvxqs	1038	11	variety	variety	NN
cord-296347-fanlvxqs	1038	12	of	of	IN
cord-296347-fanlvxqs	1038	13	diseases	disease	NNS
cord-296347-fanlvxqs	1038	14	in	in	IN
cord-296347-fanlvxqs	1038	15	humans	human	NNS
cord-296347-fanlvxqs	1038	16	has	have	VBZ
cord-296347-fanlvxqs	1038	17	two	two	CD
cord-296347-fanlvxqs	1038	18	genes	gene	NNS
cord-296347-fanlvxqs	1038	19	,	,	,
cord-296347-fanlvxqs	1038	20	ChlaDub1	ChlaDub1	NNP
cord-296347-fanlvxqs	1038	21	and	and	CC
cord-296347-fanlvxqs	1038	22	ChlaDub2	ChlaDub2	NNP
cord-296347-fanlvxqs	1038	23	,	,	,
cord-296347-fanlvxqs	1038	24	whose	whose	WP$
cord-296347-fanlvxqs	1038	25	products	product	NNS
cord-296347-fanlvxqs	1038	26	encode	encode	VBP
cord-296347-fanlvxqs	1038	27	deubiquitinating	deubiquitinate	VBG
cord-296347-fanlvxqs	1038	28	and	and	CC
cord-296347-fanlvxqs	1038	29	deNEDDylating	deneddylating	NN
cord-296347-fanlvxqs	1038	30	activitie	activitie	NN
cord-296347-fanlvxqs	1039	1	s	s	NNP
cord-296347-fanlvxqs	1040	1	(	(	-LRB-
cord-296347-fanlvxqs	1040	2	Misa	Misa	NNP
cord-296347-fanlvxqs	1040	3	ghi	ghi	NNP
cord-296347-fanlvxqs	1040	4	et	et	FW
cord-296347-fanlvxqs	1040	5	al	al	NNP
cord-296347-fanlvxqs	1040	6	.	.	NNP
cord-296347-fanlvxqs	1040	7	,	,	,
cord-296347-fanlvxqs	1040	8	2006	2006	CD
cord-296347-fanlvxqs	1040	9	)	)	-RRB-
cord-296347-fanlvxqs	1040	10	.	.	.
cord-296347-fanlvxqs	1041	1	Unlike	unlike	IN
cord-296347-fanlvxqs	1041	2	C.	C.	NNP
cord-296347-fanlvxqs	1041	3	pneum	pneum	NNP
cord-296347-fanlvxqs	1041	4	oniae	oniae	NN
cord-296347-fanlvxqs	1041	5	who	who	WP
cord-296347-fanlvxqs	1041	6	se	se	FW
cord-296347-fanlvxqs	1041	7	genome	genome	NNP
cord-296347-fanlvxqs	1041	8	is	be	VBZ
cord-296347-fanlvxqs	1041	9	devoid	devoid	JJ
cord-296347-fanlvxqs	1041	10	of	of	IN
cord-296347-fanlvxqs	1041	11	ChlaDub	ChlaDub	NNP
cord-296347-fanlvxqs	1041	12	genes	gene	NNS
cord-296347-fanlvxqs	1041	13	,	,	,
cord-296347-fanlvxqs	1041	14	C.	C.	NNP
cord-296347-fanlvxqs	1041	15	trachomatis	trachomatis	NN
cord-296347-fanlvxqs	1041	16	is	be	VBZ
cord-296347-fanlvxqs	1041	17	able	able	JJ
cord-296347-fanlvxqs	1041	18	to	to	TO
cord-296347-fanlvxqs	1041	19	block	block	VB
cord-296347-fanlvxqs	1041	20	NF	NF	NNP
cord-296347-fanlvxqs	1041	21	-	-	HYPH
cord-296347-fanlvxqs	1041	22	kB	kB	NNP
cord-296347-fanlvxqs	1041	23	signaling	signal	VBG
cord-296347-fanlvxqs	1041	24	and	and	CC
cord-296347-fanlvxqs	1041	25	thus	thus	RB
cord-296347-fanlvxqs	1041	26	the	the	DT
cord-296347-fanlvxqs	1041	27	inflammatory	inflammatory	JJ
cord-296347-fanlvxqs	1041	28	response	response	NN
cord-296347-fanlvxqs	1041	29	,	,	,
cord-296347-fanlvxqs	1041	30	as	as	RB
cord-296347-fanlvxqs	1041	31	well	well	RB
cord-296347-fanlvxqs	1041	32	as	as	IN
cord-296347-fanlvxqs	1041	33	host	host	NN
cord-296347-fanlvxqs	1041	34	cell	cell	NN
cord-296347-fanlvxqs	1041	35	apoptosis	apoptosis	NN
cord-296347-fanlvxqs	1041	36	.	.	.
cord-296347-fanlvxqs	1042	1	Both	both	DT
cord-296347-fanlvxqs	1042	2	processes	process	NNS
cord-296347-fanlvxqs	1042	3	could	could	MD
cord-296347-fanlvxqs	1042	4	be	be	VB
cord-296347-fanlvxqs	1042	5	modulated	modulate	VBN
cord-296347-fanlvxqs	1042	6	by	by	IN
cord-296347-fanlvxqs	1042	7	the	the	DT
cord-296347-fanlvxqs	1042	8	C.	C.	NNP
cord-296347-fanlvxqs	1042	9	trachomatis	trachomatis	NN
cord-296347-fanlvxqs	1042	10	DUBs	dub	NNS
cord-296347-fanlvxqs	1042	11	.	.	.
cord-296347-fanlvxqs	1043	1	These	these	DT
cord-296347-fanlvxqs	1043	2	unexpected	unexpected	JJ
cord-296347-fanlvxqs	1043	3	DUB	dub	NN
cord-296347-fanlvxqs	1043	4	activities	activity	NNS
cord-296347-fanlvxqs	1043	5	encoded	encode	VBN
cord-296347-fanlvxqs	1043	6	by	by	IN
cord-296347-fanlvxqs	1043	7	pathogens	pathogen	NNS
cord-296347-fanlvxqs	1043	8	suggest	suggest	VBP
cord-296347-fanlvxqs	1043	9	a	a	DT
cord-296347-fanlvxqs	1043	10	novel	novel	JJ
cord-296347-fanlvxqs	1043	11	strategy	strategy	NN
cord-296347-fanlvxqs	1043	12	of	of	IN
cord-296347-fanlvxqs	1043	13	modulation	modulation	NN
cord-296347-fanlvxqs	1043	14	of	of	IN
cord-296347-fanlvxqs	1043	15	host	host	NN
cord-296347-fanlvxqs	1043	16	defense	defense	NN
cord-296347-fanlvxqs	1043	17	by	by	IN
cord-296347-fanlvxqs	1043	18	manipulating	manipulate	VBG
cord-296347-fanlvxqs	1043	19	the	the	DT
cord-296347-fanlvxqs	1043	20	cellular	cellular	JJ
cord-296347-fanlvxqs	1043	21	ubiquitination	ubiquitination	NN
cord-296347-fanlvxqs	1043	22	machinery	machinery	NN
cord-296347-fanlvxqs	1043	23	.	.	.
cord-296347-fanlvxqs	1044	1	Although	although	IN
cord-296347-fanlvxqs	1044	2	the	the	DT
cord-296347-fanlvxqs	1044	3	experimental	experimental	JJ
cord-296347-fanlvxqs	1044	4	evidence	evidence	NN
cord-296347-fanlvxqs	1044	5	is	be	VBZ
cord-296347-fanlvxqs	1044	6	at	at	IN
cord-296347-fanlvxqs	1044	7	best	good	JJS
cord-296347-fanlvxqs	1044	8	tenuous	tenuous	JJ
cord-296347-fanlvxqs	1044	9	,	,	,
cord-296347-fanlvxqs	1044	10	one	one	PRP
cord-296347-fanlvxqs	1044	11	can	can	MD
cord-296347-fanlvxqs	1044	12	speculate	speculate	VB
cord-296347-fanlvxqs	1044	13	that	that	IN
cord-296347-fanlvxqs	1044	14	many	many	JJ
cord-296347-fanlvxqs	1044	15	of	of	IN
cord-296347-fanlvxqs	1044	16	these	these	DT
cord-296347-fanlvxqs	1044	17	other	other	JJ
cord-296347-fanlvxqs	1044	18	pathogen	pathogen	NN
cord-296347-fanlvxqs	1044	19	-	-	HYPH
cord-296347-fanlvxqs	1044	20	encoded	encode	VBN
cord-296347-fanlvxqs	1044	21	DUBs	dub	NNS
cord-296347-fanlvxqs	1044	22	may	may	MD
cord-296347-fanlvxqs	1044	23	be	be	VB
cord-296347-fanlvxqs	1044	24	important	important	JJ
cord-296347-fanlvxqs	1044	25	for	for	IN
cord-296347-fanlvxqs	1044	26	modulation	modulation	NN
cord-296347-fanlvxqs	1044	27	of	of	IN
cord-296347-fanlvxqs	1044	28	the	the	DT
cord-296347-fanlvxqs	1044	29	Ub	Ub	NNP
cord-296347-fanlvxqs	1044	30	-	-	HYPH
cord-296347-fanlvxqs	1044	31	proteasome	proteasome	VBN
cord-296347-fanlvxqs	1044	32	system	system	NN
cord-296347-fanlvxqs	1044	33	during	during	IN
cord-296347-fanlvxqs	1044	34	the	the	DT
cord-296347-fanlvxqs	1044	35	pathogen	pathogen	NN
cord-296347-fanlvxqs	1044	36	life	life	NN
cord-296347-fanlvxqs	1044	37	cycle	cycle	NN
cord-296347-fanlvxqs	1045	1	and/or	and/or	CC
cord-296347-fanlvxqs	1045	2	in	in	IN
cord-296347-fanlvxqs	1045	3	the	the	DT
cord-296347-fanlvxqs	1045	4	context	context	NN
cord-296347-fanlvxqs	1045	5	of	of	IN
cord-296347-fanlvxqs	1045	6	immune	immune	JJ
cord-296347-fanlvxqs	1045	7	evasion	evasion	NN
cord-296347-fanlvxqs	1045	8	.	.	.
cord-296347-fanlvxqs	1046	1	The	the	DT
cord-296347-fanlvxqs	1046	2	fact	fact	NN
cord-296347-fanlvxqs	1046	3	that	that	IN
cord-296347-fanlvxqs	1046	4	these	these	DT
cord-296347-fanlvxqs	1046	5	DUB	DUB	NNP
cord-296347-fanlvxqs	1046	6	activities	activity	NNS
cord-296347-fanlvxqs	1046	7	are	be	VBP
cord-296347-fanlvxqs	1046	8	conserved	conserve	VBN
cord-296347-fanlvxqs	1046	9	suggests	suggest	VBZ
cord-296347-fanlvxqs	1046	10	functional	functional	JJ
cord-296347-fanlvxqs	1046	11	importance	importance	NN
cord-296347-fanlvxqs	1046	12	.	.	.
cord-296347-fanlvxqs	1047	1	They	-PRON-	PRP
cord-296347-fanlvxqs	1047	2	may	may	MD
cord-296347-fanlvxqs	1047	3	be	be	VB
cord-296347-fanlvxqs	1047	4	delivered	deliver	VBN
cord-296347-fanlvxqs	1047	5	to	to	IN
cord-296347-fanlvxqs	1047	6	the	the	DT
cord-296347-fanlvxqs	1047	7	host	host	NN
cord-296347-fanlvxqs	1047	8	cell	cell	NN
cord-296347-fanlvxqs	1047	9	at	at	IN
cord-296347-fanlvxqs	1047	10	the	the	DT
cord-296347-fanlvxqs	1047	11	time	time	NN
cord-296347-fanlvxqs	1047	12	of	of	IN
cord-296347-fanlvxqs	1047	13	infection	infection	NN
cord-296347-fanlvxqs	1047	14	(	(	-LRB-
cord-296347-fanlvxqs	1047	15	for	for	IN
cord-296347-fanlvxqs	1047	16	instance	instance	NN
cord-296347-fanlvxqs	1047	17	,	,	,
cord-296347-fanlvxqs	1047	18	by	by	IN
cord-296347-fanlvxqs	1047	19	a	a	DT
cord-296347-fanlvxqs	1047	20	bacterial	bacterial	JJ
cord-296347-fanlvxqs	1047	21	type	type	NN
cord-296347-fanlvxqs	1047	22	III	iii	CD
cord-296347-fanlvxqs	1047	23	secretion	secretion	NN
cord-296347-fanlvxqs	1047	24	system	system	NN
cord-296347-fanlvxqs	1047	25	or	or	CC
cord-296347-fanlvxqs	1047	26	by	by	IN
cord-296347-fanlvxqs	1047	27	a	a	DT
cord-296347-fanlvxqs	1047	28	viral	viral	JJ
cord-296347-fanlvxqs	1047	29	tegument	tegument	NN
cord-296347-fanlvxqs	1047	30	protein	protein	NN
cord-296347-fanlvxqs	1047	31	)	)	-RRB-
cord-296347-fanlvxqs	1047	32	or	or	CC
cord-296347-fanlvxqs	1047	33	may	may	MD
cord-296347-fanlvxqs	1047	34	be	be	VB
cord-296347-fanlvxqs	1047	35	transcribed	transcribe	VBN
cord-296347-fanlvxqs	1047	36	early	early	RB
cord-296347-fanlvxqs	1047	37	during	during	IN
cord-296347-fanlvxqs	1047	38	infection	infection	NN
cord-296347-fanlvxqs	1047	39	.	.	.
cord-296347-fanlvxqs	1048	1	The	the	DT
cord-296347-fanlvxqs	1048	2	pathogen	pathogen	NN
cord-296347-fanlvxqs	1048	3	-	-	HYPH
cord-296347-fanlvxqs	1048	4	encoded	encode	VBN
cord-296347-fanlvxqs	1048	5	DUB	DUB	NNP
cord-296347-fanlvxqs	1048	6	could	could	MD
cord-296347-fanlvxqs	1048	7	interfere	interfere	VB
cord-296347-fanlvxqs	1048	8	with	with	IN
cord-296347-fanlvxqs	1048	9	the	the	DT
cord-296347-fanlvxqs	1048	10	levels	level	NNS
cord-296347-fanlvxqs	1048	11	of	of	IN
cord-296347-fanlvxqs	1048	12	Ub	Ub	NNP
cord-296347-fanlvxqs	1048	13	-	-	,
cord-296347-fanlvxqs	1048	14	or	or	CC
cord-296347-fanlvxqs	1048	15	Ubl	Ubl	NNP
cord-296347-fanlvxqs	1048	16	-	-	HYPH
cord-296347-fanlvxqs	1048	17	conjugated	conjugate	VBN
cord-296347-fanlvxqs	1048	18	proteins	protein	NNS
cord-296347-fanlvxqs	1048	19	,	,	,
cord-296347-fanlvxqs	1048	20	thereby	thereby	RB
cord-296347-fanlvxqs	1048	21	altering	alter	VBG
cord-296347-fanlvxqs	1048	22	cellular	cellular	JJ
cord-296347-fanlvxqs	1048	23	processes	process	NNS
cord-296347-fanlvxqs	1048	24	ranging	range	VBG
cord-296347-fanlvxqs	1048	25	from	from	IN
cord-296347-fanlvxqs	1048	26	signaling	signal	VBG
cord-296347-fanlvxqs	1048	27	pathways	pathway	NNS
cord-296347-fanlvxqs	1048	28	,	,	,
cord-296347-fanlvxqs	1048	29	protein	protein	NN
cord-296347-fanlvxqs	1048	30	degradation	degradation	NN
cord-296347-fanlvxqs	1048	31	,	,	,
cord-296347-fanlvxqs	1048	32	antigen	antigen	NN
cord-296347-fanlvxqs	1048	33	presentation	presentation	NN
cord-296347-fanlvxqs	1048	34	,	,	,
cord-296347-fanlvxqs	1048	35	vesicular	vesicular	JJ
cord-296347-fanlvxqs	1048	36	trafficking	trafficking	NN
cord-296347-fanlvxqs	1048	37	,	,	,
cord-296347-fanlvxqs	1048	38	and	and	CC
cord-296347-fanlvxqs	1048	39	many	many	JJ
cord-296347-fanlvxqs	1048	40	others	other	NNS
cord-296347-fanlvxqs	1048	41	.	.	.
cord-296347-fanlvxqs	1049	1	We	-PRON-	PRP
cord-296347-fanlvxqs	1049	2	have	have	VBP
cord-296347-fanlvxqs	1049	3	elaborated	elaborate	VBN
cord-296347-fanlvxqs	1049	4	on	on	IN
cord-296347-fanlvxqs	1049	5	several	several	JJ
cord-296347-fanlvxqs	1049	6	examples	example	NNS
cord-296347-fanlvxqs	1049	7	of	of	IN
cord-296347-fanlvxqs	1049	8	how	how	WRB
cord-296347-fanlvxqs	1049	9	the	the	DT
cord-296347-fanlvxqs	1049	10	host	host	NN
cord-296347-fanlvxqs	1049	11	immune	immune	JJ
cord-296347-fanlvxqs	1049	12	system	system	NN
cord-296347-fanlvxqs	1049	13	can	can	MD
cord-296347-fanlvxqs	1049	14	be	be	VB
cord-296347-fanlvxqs	1049	15	manipulated	manipulate	VBN
cord-296347-fanlvxqs	1049	16	by	by	IN
cord-296347-fanlvxqs	1049	17	a	a	DT
cord-296347-fanlvxqs	1049	18	pathogen	pathogen	NN
cord-296347-fanlvxqs	1049	19	-	-	HYPH
cord-296347-fanlvxqs	1049	20	encoded	encode	VBN
cord-296347-fanlvxqs	1049	21	E3	e3	NN
cord-296347-fanlvxqs	1049	22	or	or	CC
cord-296347-fanlvxqs	1049	23	pathogen	pathogen	NN
cord-296347-fanlvxqs	1049	24	hijacking	hijacking	NN
cord-296347-fanlvxqs	1049	25	of	of	IN
cord-296347-fanlvxqs	1049	26	a	a	DT
cord-296347-fanlvxqs	1049	27	host	host	NN
cord-296347-fanlvxqs	1049	28	E3	e3	NN
cord-296347-fanlvxqs	1049	29	.	.	.
cord-296347-fanlvxqs	1050	1	Similarly-	Similarly-	NNP
cord-296347-fanlvxqs	1051	1	and	and	CC
cord-296347-fanlvxqs	1051	2	although	although	IN
cord-296347-fanlvxqs	1051	3	the	the	DT
cord-296347-fanlvxqs	1051	4	sample	sample	NN
cord-296347-fanlvxqs	1051	5	pool	pool	NN
cord-296347-fanlvxqs	1051	6	is	be	VBZ
cord-296347-fanlvxqs	1051	7	rather	rather	RB
cord-296347-fanlvxqs	1051	8	small	small	JJ
cord-296347-fanlvxqs	1051	9	at	at	IN
cord-296347-fanlvxqs	1051	10	the	the	DT
cord-296347-fanlvxqs	1051	11	moment	moment	NN
cord-296347-fanlvxqs	1051	12	-	-	:
cord-296347-fanlvxqs	1051	13	there	there	EX
cord-296347-fanlvxqs	1051	14	is	be	VBZ
cord-296347-fanlvxqs	1051	15	no	no	DT
cord-296347-fanlvxqs	1051	16	reason	reason	NN
cord-296347-fanlvxqs	1051	17	to	to	TO
cord-296347-fanlvxqs	1051	18	believe	believe	VB
cord-296347-fanlvxqs	1051	19	that	that	IN
cord-296347-fanlvxqs	1051	20	encoding	encode	VBG
cord-296347-fanlvxqs	1051	21	their	-PRON-	PRP$
cord-296347-fanlvxqs	1051	22	own	own	JJ
cord-296347-fanlvxqs	1051	23	DUBs	dub	NNS
cord-296347-fanlvxqs	1051	24	and/or	and/or	CC
cord-296347-fanlvxqs	1051	25	hijacking	hijacking	NN
cord-296347-fanlvxqs	1051	26	of	of	IN
cord-296347-fanlvxqs	1051	27	host	host	NN
cord-296347-fanlvxqs	1051	28	DUBs	dub	NNS
cord-296347-fanlvxqs	1051	29	has	have	VBZ
cord-296347-fanlvxqs	1051	30	not	not	RB
cord-296347-fanlvxqs	1051	31	'	'	''
cord-296347-fanlvxqs	1051	32	'	'	''
cord-296347-fanlvxqs	1051	33	occurred	occur	VBD
cord-296347-fanlvxqs	1051	34	'	'	''
cord-296347-fanlvxqs	1051	35	'	'	''
cord-296347-fanlvxqs	1051	36	to	to	IN
cord-296347-fanlvxqs	1051	37	pathogens	pathogen	NNS
cord-296347-fanlvxqs	1051	38	.	.	.
cord-296347-fanlvxqs	1052	1	An	an	DT
cord-296347-fanlvxqs	1052	2	attractive	attractive	JJ
cord-296347-fanlvxqs	1052	3	possibility	possibility	NN
cord-296347-fanlvxqs	1052	4	is	be	VBZ
cord-296347-fanlvxqs	1052	5	that	that	IN
cord-296347-fanlvxqs	1052	6	some	some	DT
cord-296347-fanlvxqs	1052	7	of	of	IN
cord-296347-fanlvxqs	1052	8	these	these	DT
cord-296347-fanlvxqs	1052	9	activities	activity	NNS
cord-296347-fanlvxqs	1052	10	are	be	VBP
cord-296347-fanlvxqs	1052	11	aimed	aim	VBN
cord-296347-fanlvxqs	1052	12	at	at	IN
cord-296347-fanlvxqs	1052	13	manipulating	manipulate	VBG
cord-296347-fanlvxqs	1052	14	the	the	DT
cord-296347-fanlvxqs	1052	15	host	host	NN
cord-296347-fanlvxqs	1052	16	immune	immune	JJ
cord-296347-fanlvxqs	1052	17	system	system	NN
cord-296347-fanlvxqs	1052	18	.	.	.
cord-296347-fanlvxqs	1053	1	Possible	possible	JJ
cord-296347-fanlvxqs	1053	2	targets	target	NNS
cord-296347-fanlvxqs	1053	3	would	would	MD
cord-296347-fanlvxqs	1053	4	include	include	VB
cord-296347-fanlvxqs	1053	5	pathways	pathway	NNS
cord-296347-fanlvxqs	1053	6	involved	involve	VBN
cord-296347-fanlvxqs	1053	7	in	in	IN
cord-296347-fanlvxqs	1053	8	'	'	''
cord-296347-fanlvxqs	1053	9	'	'	``
cord-296347-fanlvxqs	1053	10	housekeeping	housekeeping	NN
cord-296347-fanlvxqs	1053	11	'	'	''
cord-296347-fanlvxqs	1053	12	'	'	''
cord-296347-fanlvxqs	1053	13	processes	process	NNS
cord-296347-fanlvxqs	1053	14	like	like	IN
cord-296347-fanlvxqs	1053	15	life	life	NN
cord-296347-fanlvxqs	1053	16	and	and	CC
cord-296347-fanlvxqs	1053	17	death	death	NN
cord-296347-fanlvxqs	1053	18	of	of	IN
cord-296347-fanlvxqs	1053	19	the	the	DT
cord-296347-fanlvxqs	1053	20	cells	cell	NNS
cord-296347-fanlvxqs	1053	21	of	of	IN
cord-296347-fanlvxqs	1053	22	the	the	DT
cord-296347-fanlvxqs	1053	23	immune	immune	JJ
cord-296347-fanlvxqs	1053	24	system	system	NN
cord-296347-fanlvxqs	1053	25	,	,	,
cord-296347-fanlvxqs	1053	26	and	and	CC
cord-296347-fanlvxqs	1053	27	extend	extend	VB
cord-296347-fanlvxqs	1053	28	to	to	IN
cord-296347-fanlvxqs	1053	29	,	,	,
cord-296347-fanlvxqs	1053	30	for	for	IN
cord-296347-fanlvxqs	1053	31	example	example	NN
cord-296347-fanlvxqs	1053	32	,	,	,
cord-296347-fanlvxqs	1053	33	interference	interference	NN
cord-296347-fanlvxqs	1053	34	with	with	IN
cord-296347-fanlvxqs	1053	35	antigen	antigen	NN
cord-296347-fanlvxqs	1053	36	presentation	presentation	NN
cord-296347-fanlvxqs	1053	37	.	.	.
cord-296347-fanlvxqs	1054	1	These	these	DT
cord-296347-fanlvxqs	1054	2	DUB	DUB	NNP
cord-296347-fanlvxqs	1054	3	activities	activity	NNS
cord-296347-fanlvxqs	1054	4	could	could	MD
cord-296347-fanlvxqs	1054	5	manipulate	manipulate	VB
cord-296347-fanlvxqs	1054	6	membrane	membrane	NN
cord-296347-fanlvxqs	1054	7	trafficking	traffic	VBG
cord-296347-fanlvxqs	1054	8	in	in	IN
cord-296347-fanlvxqs	1054	9	ways	way	NNS
cord-296347-fanlvxqs	1054	10	that	that	WDT
cord-296347-fanlvxqs	1054	11	would	would	MD
cord-296347-fanlvxqs	1054	12	prevent	prevent	VB
cord-296347-fanlvxqs	1054	13	MHC	MHC	NNP
cord-296347-fanlvxqs	1054	14	molecules	molecule	NNS
cord-296347-fanlvxqs	1054	15	from	from	IN
cord-296347-fanlvxqs	1054	16	reaching	reach	VBG
cord-296347-fanlvxqs	1054	17	the	the	DT
cord-296347-fanlvxqs	1054	18	cell	cell	NN
cord-296347-fanlvxqs	1054	19	surface	surface	NN
cord-296347-fanlvxqs	1054	20	,	,	,
cord-296347-fanlvxqs	1054	21	or	or	CC
cord-296347-fanlvxqs	1054	22	prevent	prevent	VB
cord-296347-fanlvxqs	1054	23	proteasomal	proteasomal	JJ
cord-296347-fanlvxqs	1054	24	degradation	degradation	NN
cord-296347-fanlvxqs	1054	25	of	of	IN
cord-296347-fanlvxqs	1054	26	pathogen	pathogen	NN
cord-296347-fanlvxqs	1054	27	-	-	HYPH
cord-296347-fanlvxqs	1054	28	derived	derive	VBN
cord-296347-fanlvxqs	1054	29	proteins	protein	NNS
cord-296347-fanlvxqs	1054	30	.	.	.
cord-296347-fanlvxqs	1055	1	This	this	DT
cord-296347-fanlvxqs	1055	2	initial	initial	JJ
cord-296347-fanlvxqs	1055	3	window	window	NN
cord-296347-fanlvxqs	1055	4	of	of	IN
cord-296347-fanlvxqs	1055	5	deubiquitinating	deubiquitinate	VBG
cord-296347-fanlvxqs	1055	6	activity	activity	NN
cord-296347-fanlvxqs	1055	7	could	could	MD
cord-296347-fanlvxqs	1055	8	help	help	VB
cord-296347-fanlvxqs	1055	9	viruses	virus	NNS
cord-296347-fanlvxqs	1055	10	escape	escape	VB
cord-296347-fanlvxqs	1055	11	detection	detection	NN
cord-296347-fanlvxqs	1055	12	.	.	.
cord-296347-fanlvxqs	1056	1	Bacterial	bacterial	JJ
cord-296347-fanlvxqs	1056	2	pathogens	pathogen	NNS
cord-296347-fanlvxqs	1056	3	could	could	MD
cord-296347-fanlvxqs	1056	4	benefit	benefit	VB
cord-296347-fanlvxqs	1056	5	from	from	IN
cord-296347-fanlvxqs	1056	6	targeting	target	VBG
cord-296347-fanlvxqs	1056	7	of	of	IN
cord-296347-fanlvxqs	1056	8	transcription	transcription	NN
cord-296347-fanlvxqs	1056	9	factors	factor	NNS
cord-296347-fanlvxqs	1056	10	and	and	CC
cord-296347-fanlvxqs	1056	11	cytokine	cytokine	NN
cord-296347-fanlvxqs	1056	12	signaling	signal	VBG
cord-296347-fanlvxqs	1056	13	networks	network	NNS
cord-296347-fanlvxqs	1056	14	that	that	WDT
cord-296347-fanlvxqs	1056	15	are	be	VBP
cord-296347-fanlvxqs	1056	16	crucial	crucial	JJ
cord-296347-fanlvxqs	1056	17	for	for	IN
cord-296347-fanlvxqs	1056	18	coordination	coordination	NN
cord-296347-fanlvxqs	1056	19	of	of	IN
cord-296347-fanlvxqs	1056	20	macrophage	macrophage	NN
cord-296347-fanlvxqs	1056	21	effector	effector	NN
cord-296347-fanlvxqs	1056	22	functions	function	NNS
cord-296347-fanlvxqs	1056	23	.	.	.
cord-296347-fanlvxqs	1057	1	Other	other	JJ
cord-296347-fanlvxqs	1057	2	immune	immune	JJ
cord-296347-fanlvxqs	1057	3	responses	response	NNS
cord-296347-fanlvxqs	1057	4	that	that	WDT
cord-296347-fanlvxqs	1057	5	could	could	MD
cord-296347-fanlvxqs	1057	6	,	,	,
cord-296347-fanlvxqs	1057	7	in	in	IN
cord-296347-fanlvxqs	1057	8	principle	principle	NN
cord-296347-fanlvxqs	1057	9	,	,	,
cord-296347-fanlvxqs	1057	10	be	be	VB
cord-296347-fanlvxqs	1057	11	controlled	control	VBN
cord-296347-fanlvxqs	1057	12	by	by	IN
cord-296347-fanlvxqs	1057	13	DUBs	dub	NNS
cord-296347-fanlvxqs	1057	14	are	be	VBP
cord-296347-fanlvxqs	1057	15	IFN	IFN	NNP
cord-296347-fanlvxqs	1057	16	and	and	CC
cord-296347-fanlvxqs	1057	17	NF	nf	NN
cord-296347-fanlvxqs	1057	18	-	-	HYPH
cord-296347-fanlvxqs	1057	19	NF	NF	NNP
cord-296347-fanlvxqs	1057	20	-	-	HYPH
cord-296347-fanlvxqs	1057	21	kB	kB	NNP
cord-296347-fanlvxqs	1057	22	signaling	signaling	NN
cord-296347-fanlvxqs	1057	23	,	,	,
cord-296347-fanlvxqs	1057	24	and	and	CC
cord-296347-fanlvxqs	1057	25	the	the	DT
cord-296347-fanlvxqs	1057	26	posttranscriptional	posttranscriptional	JJ
cord-296347-fanlvxqs	1057	27	gene	gene	NN
cord-296347-fanlvxqs	1057	28	silencing	silence	VBG
cord-296347-fanlvxqs	1057	29	'	'	''
cord-296347-fanlvxqs	1057	30	'	'	``
cord-296347-fanlvxqs	1057	31	immune	immune	JJ
cord-296347-fanlvxqs	1057	32	response	response	NN
cord-296347-fanlvxqs	1057	33	'	'	''
cord-296347-fanlvxqs	1057	34	'	'	''
cord-296347-fanlvxqs	1057	35	at	at	IN
cord-296347-fanlvxqs	1057	36	least	least	JJS
cord-296347-fanlvxqs	1057	37	in	in	IN
cord-296347-fanlvxqs	1057	38	plants	plant	NNS
cord-296347-fanlvxqs	1057	39	.	.	.
cord-296347-fanlvxqs	1058	1	The	the	DT
cord-296347-fanlvxqs	1058	2	possibilities	possibility	NNS
cord-296347-fanlvxqs	1058	3	are	be	VBP
cord-296347-fanlvxqs	1058	4	endless	endless	JJ
cord-296347-fanlvxqs	1058	5	.	.	.
cord-296347-fanlvxqs	1059	1	Exploitation	exploitation	NN
cord-296347-fanlvxqs	1059	2	of	of	IN
cord-296347-fanlvxqs	1059	3	the	the	DT
cord-296347-fanlvxqs	1059	4	Ub	Ub	NNP
cord-296347-fanlvxqs	1059	5	-	-	HYPH
cord-296347-fanlvxqs	1059	6	proteasome	proteasome	VBN
cord-296347-fanlvxqs	1059	7	system	system	NN
cord-296347-fanlvxqs	1059	8	by	by	IN
cord-296347-fanlvxqs	1059	9	pathogens	pathogen	NNS
cord-296347-fanlvxqs	1059	10	to	to	TO
cord-296347-fanlvxqs	1059	11	enhance	enhance	VB
cord-296347-fanlvxqs	1059	12	their	-PRON-	PRP$
cord-296347-fanlvxqs	1059	13	own	own	JJ
cord-296347-fanlvxqs	1059	14	survival	survival	NN
cord-296347-fanlvxqs	1059	15	is	be	VBZ
cord-296347-fanlvxqs	1059	16	beginning	begin	VBG
cord-296347-fanlvxqs	1059	17	to	to	TO
cord-296347-fanlvxqs	1059	18	emerge	emerge	VB
cord-296347-fanlvxqs	1059	19	as	as	IN
cord-296347-fanlvxqs	1059	20	a	a	DT
cord-296347-fanlvxqs	1059	21	central	central	JJ
cord-296347-fanlvxqs	1059	22	theme	theme	NN
cord-296347-fanlvxqs	1059	23	.	.	.
cord-296347-fanlvxqs	1060	1	The	the	DT
cord-296347-fanlvxqs	1060	2	development	development	NN
cord-296347-fanlvxqs	1060	3	of	of	IN
cord-296347-fanlvxqs	1060	4	the	the	DT
cord-296347-fanlvxqs	1060	5	appropriate	appropriate	JJ
cord-296347-fanlvxqs	1060	6	genetic	genetic	JJ
cord-296347-fanlvxqs	1060	7	and	and	CC
cord-296347-fanlvxqs	1060	8	biochemical	biochemical	JJ
cord-296347-fanlvxqs	1060	9	tools	tool	NNS
cord-296347-fanlvxqs	1060	10	will	will	MD
cord-296347-fanlvxqs	1060	11	help	help	VB
cord-296347-fanlvxqs	1060	12	place	place	VB
cord-296347-fanlvxqs	1060	13	this	this	DT
cord-296347-fanlvxqs	1060	14	subject	subject	NN
cord-296347-fanlvxqs	1060	15	in	in	IN
cord-296347-fanlvxqs	1060	16	the	the	DT
cord-296347-fanlvxqs	1060	17	realm	realm	NN
cord-296347-fanlvxqs	1060	18	of	of	IN
cord-296347-fanlvxqs	1060	19	essential	essential	JJ
cord-296347-fanlvxqs	1060	20	host	host	NN
cord-296347-fanlvxqs	1060	21	-	-	HYPH
cord-296347-fanlvxqs	1060	22	pathogen	pathogen	NN
cord-296347-fanlvxqs	1060	23	interactions	interaction	NNS
cord-296347-fanlvxqs	1060	24	.	.	.
cord-296347-fanlvxqs	1061	1	The	the	DT
cord-296347-fanlvxqs	1061	2	proteasome	proteasome	NN
cord-296347-fanlvxqs	1061	3	:	:	:
cord-296347-fanlvxqs	1061	4	Structure	structure	NN
cord-296347-fanlvxqs	1061	5	,	,	,
cord-296347-fanlvxqs	1061	6	function	function	NN
cord-296347-fanlvxqs	1061	7	,	,	,
cord-296347-fanlvxqs	1061	8	and	and	CC
cord-296347-fanlvxqs	1061	9	role	role	NN
cord-296347-fanlvxqs	1061	10	in	in	IN
cord-296347-fanlvxqs	1061	11	the	the	DT
cord-296347-fanlvxqs	1061	12	cell	cell	NN
cord-296347-fanlvxqs	1061	13	Human	Human	NNP
cord-296347-fanlvxqs	1061	14	cytomegalovirus	cytomegalovirus	NN
cord-296347-fanlvxqs	1061	15	inhibits	inhibit	VBZ
cord-296347-fanlvxqs	1061	16	antigen	antigen	NN
cord-296347-fanlvxqs	1061	17	presentation	presentation	NN
cord-296347-fanlvxqs	1061	18	by	by	IN
cord-296347-fanlvxqs	1061	19	a	a	DT
cord-296347-fanlvxqs	1061	20	sequential	sequential	JJ
cord-296347-fanlvxqs	1061	21	multistep	multistep	NN
cord-296347-fanlvxqs	1061	22	process	process	NN
cord-296347-fanlvxqs	1062	1	The	the	DT
cord-296347-fanlvxqs	1062	2	ER	ER	NNP
cord-296347-fanlvxqs	1062	3	-	-	HYPH
cord-296347-fanlvxqs	1062	4	luminal	luminal	JJ
cord-296347-fanlvxqs	1062	5	domain	domain	NN
cord-296347-fanlvxqs	1062	6	of	of	IN
cord-296347-fanlvxqs	1062	7	the	the	DT
cord-296347-fanlvxqs	1062	8	HCMV	HCMV	NNP
cord-296347-fanlvxqs	1062	9	glycoprotein	glycoprotein	NN
cord-296347-fanlvxqs	1062	10	US6	US6	NNP
cord-296347-fanlvxqs	1062	11	inhibits	inhibit	VBZ
cord-296347-fanlvxqs	1062	12	peptide	peptide	JJ
cord-296347-fanlvxqs	1062	13	translocation	translocation	NN
cord-296347-fanlvxqs	1062	14	by	by	IN
cord-296347-fanlvxqs	1062	15	Nef	Nef	NNP
cord-296347-fanlvxqs	1062	16	induces	induce	VBZ
cord-296347-fanlvxqs	1062	17	CD4	CD4	NNP
cord-296347-fanlvxqs	1062	18	endocytosis	endocytosis	NN
cord-296347-fanlvxqs	1062	19	:	:	:
cord-296347-fanlvxqs	1063	1	Requirement	requirement	NN
cord-296347-fanlvxqs	1063	2	for	for	IN
cord-296347-fanlvxqs	1063	3	a	a	DT
cord-296347-fanlvxqs	1063	4	critical	critical	JJ
cord-296347-fanlvxqs	1063	5	dileucine	dileucine	NN
cord-296347-fanlvxqs	1063	6	motif	motif	NN
cord-296347-fanlvxqs	1063	7	in	in	IN
cord-296347-fanlvxqs	1063	8	the	the	DT
cord-296347-fanlvxqs	1063	9	membrane	membrane	NN
cord-296347-fanlvxqs	1063	10	-	-	HYPH
cord-296347-fanlvxqs	1063	11	proximal	proximal	JJ
cord-296347-fanlvxqs	1063	12	CD4	CD4	NNP
cord-296347-fanlvxqs	1063	13	cytoplasmic	cytoplasmic	JJ
cord-296347-fanlvxqs	1063	14	domain	domain	NN
cord-296347-fanlvxqs	1063	15	Core	core	NN
cord-296347-fanlvxqs	1063	16	protein	protein	NN
cord-296347-fanlvxqs	1063	17	cleavage	cleavage	NN
cord-296347-fanlvxqs	1063	18	by	by	IN
cord-296347-fanlvxqs	1063	19	signal	signal	NN
cord-296347-fanlvxqs	1063	20	peptide	peptide	NN
cord-296347-fanlvxqs	1063	21	peptidase	peptidase	NN
cord-296347-fanlvxqs	1063	22	is	be	VBZ
cord-296347-fanlvxqs	1063	23	required	require	VBN
cord-296347-fanlvxqs	1063	24	for	for	IN
cord-296347-fanlvxqs	1063	25	hepatitis	hepatitis	NN
cord-296347-fanlvxqs	1063	26	C	C	NNP
cord-296347-fanlvxqs	1063	27	virus	virus	NN
cord-296347-fanlvxqs	1063	28	-	-	:
cord-296347-fanlvxqs	1063	29	like	like	JJ
cord-296347-fanlvxqs	1063	30	particle	particle	NN
cord-296347-fanlvxqs	1063	31	assembly	assembly	NN
cord-296347-fanlvxqs	1063	32	Pathogen	Pathogen	NNP
cord-296347-fanlvxqs	1063	33	recognition	recognition	NN
cord-296347-fanlvxqs	1063	34	and	and	CC
cord-296347-fanlvxqs	1063	35	innate	innate	JJ
cord-296347-fanlvxqs	1063	36	immunity	immunity	NN
cord-296347-fanlvxqs	1063	37	T	t	NN
cord-296347-fanlvxqs	1063	38	-	-	HYPH
cord-296347-fanlvxqs	1063	39	cell	cell	NN
cord-296347-fanlvxqs	1063	40	-	-	HYPH
cord-296347-fanlvxqs	1063	41	receptor	receptor	NN
cord-296347-fanlvxqs	1063	42	affinity	affinity	NN
cord-296347-fanlvxqs	1063	43	and	and	CC
cord-296347-fanlvxqs	1063	44	thymocyte	thymocyte	NN
cord-296347-fanlvxqs	1063	45	positive	positive	JJ
cord-296347-fanlvxqs	1063	46	selection	selection	NN
cord-296347-fanlvxqs	1063	47	Viral	viral	JJ
cord-296347-fanlvxqs	1063	48	mimicry	mimicry	NN
cord-296347-fanlvxqs	1063	49	of	of	IN
cord-296347-fanlvxqs	1063	50	cytokines	cytokine	NNS
cord-296347-fanlvxqs	1063	51	,	,	,
cord-296347-fanlvxqs	1063	52	chemokines	chemokine	NNS
cord-296347-fanlvxqs	1063	53	and	and	CC
cord-296347-fanlvxqs	1063	54	their	-PRON-	PRP$
cord-296347-fanlvxqs	1063	55	receptors	receptor	NNS
cord-296347-fanlvxqs	1063	56	Viral	viral	JJ
cord-296347-fanlvxqs	1063	57	mechanisms	mechanism	NNS
cord-296347-fanlvxqs	1063	58	of	of	IN
cord-296347-fanlvxqs	1063	59	immune	immune	JJ
cord-296347-fanlvxqs	1063	60	evasion	evasion	NN
cord-296347-fanlvxqs	1063	61	Viral	viral	JJ
cord-296347-fanlvxqs	1063	62	interference	interference	NN
cord-296347-fanlvxqs	1063	63	with	with	IN
cord-296347-fanlvxqs	1063	64	MHC	MHC	NNP
cord-296347-fanlvxqs	1063	65	class	class	NN
cord-296347-fanlvxqs	1063	66	I	-PRON-	PRP
cord-296347-fanlvxqs	1063	67	antigen	antigen	NN
cord-296347-fanlvxqs	1063	68	presentation	presentation	NN
cord-296347-fanlvxqs	1063	69	pathway	pathway	NN
cord-296347-fanlvxqs	1063	70	:	:	:
cord-296347-fanlvxqs	1064	1	The	the	DT
cord-296347-fanlvxqs	1064	2	battle	battle	NN
cord-296347-fanlvxqs	1064	3	continues	continue	VBZ
cord-296347-fanlvxqs	1064	4	Mechanism	mechanism	NN
cord-296347-fanlvxqs	1064	5	and	and	CC
cord-296347-fanlvxqs	1064	6	function	function	NN
cord-296347-fanlvxqs	1064	7	of	of	IN
cord-296347-fanlvxqs	1064	8	deubiquitinating	deubiquitinating	NN
cord-296347-fanlvxqs	1064	9	enzymes	enzyme	NNS
cord-296347-fanlvxqs	1064	10	Cytotoxic	Cytotoxic	NNP
cord-296347-fanlvxqs	1064	11	T	t	NN
cord-296347-fanlvxqs	1064	12	cells	cell	NNS
cord-296347-fanlvxqs	1065	1	An	an	DT
cord-296347-fanlvxqs	1065	2	inhibitor	inhibitor	NN
cord-296347-fanlvxqs	1065	3	of	of	IN
cord-296347-fanlvxqs	1065	4	HIV-1	HIV-1	NNP
cord-296347-fanlvxqs	1065	5	protease	protease	NN
cord-296347-fanlvxqs	1065	6	modulates	modulate	VBZ
cord-296347-fanlvxqs	1065	7	proteasome	proteasome	JJ
cord-296347-fanlvxqs	1065	8	activity	activity	NN
cord-296347-fanlvxqs	1065	9	,	,	,
cord-296347-fanlvxqs	1065	10	antigen	antigen	NN
cord-296347-fanlvxqs	1065	11	presentation	presentation	NN
cord-296347-fanlvxqs	1065	12	,	,	,
cord-296347-fanlvxqs	1065	13	and	and	CC
cord-296347-fanlvxqs	1065	14	T	t	NN
cord-296347-fanlvxqs	1065	15	cell	cell	NN
cord-296347-fanlvxqs	1065	16	responses	response	NNS
cord-296347-fanlvxqs	1065	17	Vacuolar	Vacuolar	NNP
cord-296347-fanlvxqs	1065	18	H(þ)-ATPase	h(þ)-atpase	NN
cord-296347-fanlvxqs	1065	19	mutants	mutant	NNS
cord-296347-fanlvxqs	1065	20	transform	transform	VBP
cord-296347-fanlvxqs	1065	21	cells	cell	NNS
cord-296347-fanlvxqs	1065	22	and	and	CC
cord-296347-fanlvxqs	1065	23	define	define	VB
cord-296347-fanlvxqs	1065	24	a	a	DT
cord-296347-fanlvxqs	1065	25	binding	binding	JJ
cord-296347-fanlvxqs	1065	26	site	site	NN
cord-296347-fanlvxqs	1065	27	for	for	IN
cord-296347-fanlvxqs	1065	28	the	the	DT
cord-296347-fanlvxqs	1065	29	papillomavirus	papillomavirus	NN
cord-296347-fanlvxqs	1065	30	E5	E5	NNP
cord-296347-fanlvxqs	1065	31	oncoprotein	oncoprotein	NNP
cord-296347-fanlvxqs	1065	32	Human	Human	NNP
cord-296347-fanlvxqs	1065	33	immunodeficiency	immunodeficiency	NN
cord-296347-fanlvxqs	1065	34	virus-1	virus-1	NN
cord-296347-fanlvxqs	1065	35	Tat	Tat	NNP
cord-296347-fanlvxqs	1065	36	protein	protein	NN
cord-296347-fanlvxqs	1065	37	interacts	interact	VBZ
cord-296347-fanlvxqs	1065	38	with	with	IN
cord-296347-fanlvxqs	1065	39	distinct	distinct	JJ
cord-296347-fanlvxqs	1065	40	proteasomal	proteasomal	JJ
cord-296347-fanlvxqs	1065	41	alpha	alpha	NN
cord-296347-fanlvxqs	1065	42	and	and	CC
cord-296347-fanlvxqs	1065	43	beta	beta	NN
cord-296347-fanlvxqs	1065	44	subunits	subunit	NNS
cord-296347-fanlvxqs	1065	45	E3	E3	NNP
cord-296347-fanlvxqs	1065	46	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1065	47	ligases	ligase	NNS
cord-296347-fanlvxqs	1066	1	Inhibition	inhibition	NN
cord-296347-fanlvxqs	1066	2	of	of	IN
cord-296347-fanlvxqs	1066	3	the	the	DT
cord-296347-fanlvxqs	1066	4	NKp30	NKp30	NNS
cord-296347-fanlvxqs	1066	5	activating	activate	VBG
cord-296347-fanlvxqs	1066	6	receptor	receptor	NN
cord-296347-fanlvxqs	1066	7	by	by	IN
cord-296347-fanlvxqs	1066	8	pp65	pp65	NNS
cord-296347-fanlvxqs	1066	9	of	of	IN
cord-296347-fanlvxqs	1066	10	human	human	JJ
cord-296347-fanlvxqs	1066	11	cytomegalovirus	cytomegalovirus	NNP
cord-296347-fanlvxqs	1066	12	Mammalian	mammalian	JJ
cord-296347-fanlvxqs	1066	13	tumor	tumor	NN
cord-296347-fanlvxqs	1066	14	susceptibility	susceptibility	NN
cord-296347-fanlvxqs	1066	15	gene	gene	NN
cord-296347-fanlvxqs	1066	16	101	101	CD
cord-296347-fanlvxqs	1066	17	(	(	-LRB-
cord-296347-fanlvxqs	1066	18	TSG101	TSG101	NNP
cord-296347-fanlvxqs	1066	19	)	)	-RRB-
cord-296347-fanlvxqs	1066	20	and	and	CC
cord-296347-fanlvxqs	1066	21	the	the	DT
cord-296347-fanlvxqs	1066	22	yeast	yeast	NN
cord-296347-fanlvxqs	1066	23	homologue	homologue	NN
cord-296347-fanlvxqs	1066	24	,	,	,
cord-296347-fanlvxqs	1066	25	Vps23p	Vps23p	NNP
cord-296347-fanlvxqs	1066	26	,	,	,
cord-296347-fanlvxqs	1066	27	both	both	DT
cord-296347-fanlvxqs	1066	28	function	function	VBP
cord-296347-fanlvxqs	1066	29	in	in	IN
cord-296347-fanlvxqs	1066	30	late	late	JJ
cord-296347-fanlvxqs	1066	31	endosomal	endosomal	NNP
cord-296347-fanlvxqs	1066	32	trafficking	traffic	VBG
cord-296347-fanlvxqs	1066	33	Activation	Activation	NNP
cord-296347-fanlvxqs	1066	34	of	of	IN
cord-296347-fanlvxqs	1066	35	natural	natural	JJ
cord-296347-fanlvxqs	1066	36	killer	killer	NN
cord-296347-fanlvxqs	1066	37	cells	cell	NNS
cord-296347-fanlvxqs	1066	38	:	:	:
cord-296347-fanlvxqs	1066	39	Underlying	underlie	VBG
cord-296347-fanlvxqs	1066	40	molecular	molecular	JJ
cord-296347-fanlvxqs	1066	41	mechanisms	mechanism	NNS
cord-296347-fanlvxqs	1066	42	revealed	reveal	VBD
cord-296347-fanlvxqs	1066	43	Deubiquitinating	Deubiquitinating	NNP
cord-296347-fanlvxqs	1066	44	function	function	NN
cord-296347-fanlvxqs	1066	45	of	of	IN
cord-296347-fanlvxqs	1066	46	adenovirus	adenovirus	NN
cord-296347-fanlvxqs	1066	47	proteinase	proteinase	NN
cord-296347-fanlvxqs	1066	48	Viruses	virus	NNS
cord-296347-fanlvxqs	1066	49	and	and	CC
cord-296347-fanlvxqs	1066	50	the	the	DT
cord-296347-fanlvxqs	1066	51	26S	26S	NNP
cord-296347-fanlvxqs	1066	52	proteasome	proteasome	NN
cord-296347-fanlvxqs	1066	53	:	:	:
cord-296347-fanlvxqs	1067	1	Hacking	hack	VBG
cord-296347-fanlvxqs	1067	2	into	into	IN
cord-296347-fanlvxqs	1067	3	destruction	destruction	NN
cord-296347-fanlvxqs	1067	4	Human	human	JJ
cord-296347-fanlvxqs	1067	5	cytomegalovirus	cytomegalovirus	NN
cord-296347-fanlvxqs	1067	6	-	-	HYPH
cord-296347-fanlvxqs	1067	7	encoded	encode	VBN
cord-296347-fanlvxqs	1067	8	US2	US2	NNP
cord-296347-fanlvxqs	1067	9	differentially	differentially	RB
cord-296347-fanlvxqs	1067	10	affects	affect	VBZ
cord-296347-fanlvxqs	1067	11	surface	surface	NN
cord-296347-fanlvxqs	1067	12	expression	expression	NN
cord-296347-fanlvxqs	1067	13	of	of	IN
cord-296347-fanlvxqs	1067	14	MHC	MHC	NNP
cord-296347-fanlvxqs	1067	15	class	class	NN
cord-296347-fanlvxqs	1067	16	I	-PRON-	PRP
cord-296347-fanlvxqs	1067	17	locus	locus	NN
cord-296347-fanlvxqs	1067	18	products	product	NNS
cord-296347-fanlvxqs	1067	19	and	and	CC
cord-296347-fanlvxqs	1067	20	targets	target	VBZ
cord-296347-fanlvxqs	1067	21	membrane	membrane	NN
cord-296347-fanlvxqs	1067	22	-	-	HYPH
cord-296347-fanlvxqs	1067	23	bound	bind	VBN
cord-296347-fanlvxqs	1067	24	,	,	,
cord-296347-fanlvxqs	1067	25	but	but	CC
cord-296347-fanlvxqs	1067	26	not	not	RB
cord-296347-fanlvxqs	1067	27	soluble	soluble	JJ
cord-296347-fanlvxqs	1067	28	HLA	HLA	NNP
cord-296347-fanlvxqs	1067	29	-	-	HYPH
cord-296347-fanlvxqs	1067	30	G1	g1	NN
cord-296347-fanlvxqs	1067	31	for	for	IN
cord-296347-fanlvxqs	1067	32	degradation	degradation	NN
cord-296347-fanlvxqs	1067	33	Subtle	subtle	JJ
cord-296347-fanlvxqs	1067	34	sequence	sequence	NN
cord-296347-fanlvxqs	1067	35	variation	variation	NN
cord-296347-fanlvxqs	1067	36	among	among	IN
cord-296347-fanlvxqs	1067	37	MHC	MHC	NNP
cord-296347-fanlvxqs	1067	38	class	class	NN
cord-296347-fanlvxqs	1067	39	I	-PRON-	PRP
cord-296347-fanlvxqs	1067	40	locus	locus	NN
cord-296347-fanlvxqs	1067	41	products	product	NNS
cord-296347-fanlvxqs	1067	42	greatly	greatly	RB
cord-296347-fanlvxqs	1067	43	influences	influence	VBZ
cord-296347-fanlvxqs	1067	44	sensitivity	sensitivity	NN
cord-296347-fanlvxqs	1067	45	to	to	IN
cord-296347-fanlvxqs	1067	46	HCMV	HCMV	NNP
cord-296347-fanlvxqs	1067	47	US2-and	US2-and	NNP
cord-296347-fanlvxqs	1067	48	US11-mediated	us11-mediated	CD
cord-296347-fanlvxqs	1067	49	degradation	degradation	NN
cord-296347-fanlvxqs	1068	1	The	the	DT
cord-296347-fanlvxqs	1068	2	papain	papain	NN
cord-296347-fanlvxqs	1068	3	-	-	HYPH
cord-296347-fanlvxqs	1068	4	like	like	JJ
cord-296347-fanlvxqs	1068	5	protease	protease	NN
cord-296347-fanlvxqs	1068	6	of	of	IN
cord-296347-fanlvxqs	1068	7	severe	severe	JJ
cord-296347-fanlvxqs	1068	8	acute	acute	JJ
cord-296347-fanlvxqs	1068	9	respiratory	respiratory	JJ
cord-296347-fanlvxqs	1068	10	syndrome	syndrome	NN
cord-296347-fanlvxqs	1068	11	coronavirus	coronavirus	NN
cord-296347-fanlvxqs	1068	12	has	have	VBZ
cord-296347-fanlvxqs	1068	13	deubiquitinating	deubiquitinate	VBG
cord-296347-fanlvxqs	1068	14	activity	activity	NN
cord-296347-fanlvxqs	1068	15	Viral	viral	JJ
cord-296347-fanlvxqs	1068	16	modulators	modulator	NNS
cord-296347-fanlvxqs	1068	17	of	of	IN
cord-296347-fanlvxqs	1068	18	cullin	cullin	NNP
cord-296347-fanlvxqs	1068	19	RING	ring	NN
cord-296347-fanlvxqs	1068	20	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1068	21	ligases	ligase	NNS
cord-296347-fanlvxqs	1068	22	:	:	:
cord-296347-fanlvxqs	1068	23	Culling	cull	VBG
cord-296347-fanlvxqs	1068	24	the	the	DT
cord-296347-fanlvxqs	1068	25	host	host	NN
cord-296347-fanlvxqs	1068	26	defense	defense	NN
cord-296347-fanlvxqs	1068	27	Downregulation	Downregulation	NNP
cord-296347-fanlvxqs	1068	28	of	of	IN
cord-296347-fanlvxqs	1068	29	major	major	JJ
cord-296347-fanlvxqs	1068	30	histocompatibility	histocompatibility	NN
cord-296347-fanlvxqs	1068	31	complex	complex	JJ
cord-296347-fanlvxqs	1068	32	class	class	NN
cord-296347-fanlvxqs	1069	1	I	-PRON-	PRP
cord-296347-fanlvxqs	1069	2	by	by	IN
cord-296347-fanlvxqs	1069	3	human	human	JJ
cord-296347-fanlvxqs	1069	4	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1069	5	ligases	ligase	NNS
cord-296347-fanlvxqs	1069	6	related	relate	VBN
cord-296347-fanlvxqs	1069	7	to	to	IN
cord-296347-fanlvxqs	1069	8	viral	viral	JJ
cord-296347-fanlvxqs	1069	9	immune	immune	JJ
cord-296347-fanlvxqs	1069	10	evasion	evasion	NN
cord-296347-fanlvxqs	1069	11	proteins	protein	NNS
cord-296347-fanlvxqs	1070	1	Cdc48-Ufd1-Npl4	Cdc48-Ufd1-Npl4	NNS
cord-296347-fanlvxqs	1070	2	:	:	:
cord-296347-fanlvxqs	1071	1	Stuck	stick	VBN
cord-296347-fanlvxqs	1071	2	in	in	IN
cord-296347-fanlvxqs	1071	3	the	the	DT
cord-296347-fanlvxqs	1071	4	middle	middle	NN
cord-296347-fanlvxqs	1071	5	with	with	IN
cord-296347-fanlvxqs	1071	6	Ub	Ub	NNP
cord-296347-fanlvxqs	1071	7	Hrd1p/	Hrd1p/	NNP
cord-296347-fanlvxqs	1072	1	Der3p	Der3p	NNP
cord-296347-fanlvxqs	1072	2	is	be	VBZ
cord-296347-fanlvxqs	1072	3	a	a	DT
cord-296347-fanlvxqs	1072	4	membrane	membrane	NN
cord-296347-fanlvxqs	1072	5	-	-	HYPH
cord-296347-fanlvxqs	1072	6	anchored	anchor	VBN
cord-296347-fanlvxqs	1072	7	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1072	8	ligase	ligase	NN
cord-296347-fanlvxqs	1072	9	required	require	VBN
cord-296347-fanlvxqs	1072	10	for	for	IN
cord-296347-fanlvxqs	1072	11	ER	ER	NNP
cord-296347-fanlvxqs	1072	12	-	-	HYPH
cord-296347-fanlvxqs	1072	13	associated	associate	VBN
cord-296347-fanlvxqs	1072	14	degradation	degradation	NN
cord-296347-fanlvxqs	1072	15	Regulatory	Regulatory	NNP
cord-296347-fanlvxqs	1072	16	T	T	NNP
cord-296347-fanlvxqs	1072	17	cells	cell	NNS
cord-296347-fanlvxqs	1072	18	Evidence	evidence	NN
cord-296347-fanlvxqs	1072	19	that	that	IN
cord-296347-fanlvxqs	1072	20	HIV-1	HIV-1	NNP
cord-296347-fanlvxqs	1072	21	encodes	encode	VBZ
cord-296347-fanlvxqs	1072	22	an	an	DT
cord-296347-fanlvxqs	1072	23	siRNA	sirna	NN
cord-296347-fanlvxqs	1072	24	and	and	CC
cord-296347-fanlvxqs	1072	25	a	a	DT
cord-296347-fanlvxqs	1072	26	suppressor	suppressor	NN
cord-296347-fanlvxqs	1072	27	of	of	IN
cord-296347-fanlvxqs	1072	28	RNA	RNA	NNP
cord-296347-fanlvxqs	1072	29	silencing	silence	VBG
cord-296347-fanlvxqs	1072	30	Intrinsic	intrinsic	JJ
cord-296347-fanlvxqs	1072	31	immunity	immunity	NN
cord-296347-fanlvxqs	1072	32	:	:	:
cord-296347-fanlvxqs	1072	33	A	a	DT
cord-296347-fanlvxqs	1072	34	front	front	JJ
cord-296347-fanlvxqs	1072	35	-	-	HYPH
cord-296347-fanlvxqs	1072	36	line	line	NN
cord-296347-fanlvxqs	1072	37	defense	defense	NN
cord-296347-fanlvxqs	1072	38	against	against	IN
cord-296347-fanlvxqs	1072	39	viral	viral	JJ
cord-296347-fanlvxqs	1072	40	attack	attack	NN
cord-296347-fanlvxqs	1073	1	Late	late	JJ
cord-296347-fanlvxqs	1073	2	budding	bud	VBG
cord-296347-fanlvxqs	1073	3	domains	domain	NNS
cord-296347-fanlvxqs	1073	4	and	and	CC
cord-296347-fanlvxqs	1073	5	host	host	NN
cord-296347-fanlvxqs	1073	6	proteins	protein	NNS
cord-296347-fanlvxqs	1073	7	in	in	IN
cord-296347-fanlvxqs	1073	8	enveloped	envelop	VBN
cord-296347-fanlvxqs	1073	9	virus	virus	NN
cord-296347-fanlvxqs	1073	10	release	release	NN
cord-296347-fanlvxqs	1073	11	Cytidine	cytidine	JJ
cord-296347-fanlvxqs	1073	12	deamination	deamination	NN
cord-296347-fanlvxqs	1073	13	of	of	IN
cord-296347-fanlvxqs	1073	14	retroviral	retroviral	JJ
cord-296347-fanlvxqs	1073	15	DNA	dna	NN
cord-296347-fanlvxqs	1073	16	by	by	IN
cord-296347-fanlvxqs	1073	17	diverse	diverse	JJ
cord-296347-fanlvxqs	1073	18	APOBEC	APOBEC	NNP
cord-296347-fanlvxqs	1073	19	proteins	protein	NNS
cord-296347-fanlvxqs	1074	1	APOBEC	APOBEC	NNP
cord-296347-fanlvxqs	1074	2	-	-	HYPH
cord-296347-fanlvxqs	1074	3	mediated	mediate	VBN
cord-296347-fanlvxqs	1074	4	editing	editing	NN
cord-296347-fanlvxqs	1074	5	of	of	IN
cord-296347-fanlvxqs	1074	6	viral	viral	JJ
cord-296347-fanlvxqs	1074	7	RNA	RNA	NNP
cord-296347-fanlvxqs	1074	8	A	A	NNP
cord-296347-fanlvxqs	1074	9	glycosylated	glycosylated	JJ
cord-296347-fanlvxqs	1074	10	type	type	NN
cord-296347-fanlvxqs	1074	11	I	-PRON-	PRP
cord-296347-fanlvxqs	1074	12	membrane	membrane	NN
cord-296347-fanlvxqs	1074	13	protein	protein	NN
cord-296347-fanlvxqs	1074	14	becomes	become	VBZ
cord-296347-fanlvxqs	1074	15	cytosolic	cytosolic	JJ
cord-296347-fanlvxqs	1074	16	when	when	WRB
cord-296347-fanlvxqs	1074	17	peptide	peptide	NN
cord-296347-fanlvxqs	1074	18	:	:	:
cord-296347-fanlvxqs	1075	1	N	N	NNP
cord-296347-fanlvxqs	1075	2	-	-	HYPH
cord-296347-fanlvxqs	1075	3	glycanase	glycanase	NN
cord-296347-fanlvxqs	1075	4	is	be	VBZ
cord-296347-fanlvxqs	1075	5	compromised	compromise	VBN
cord-296347-fanlvxqs	1075	6	MHC	MHC	NNP
cord-296347-fanlvxqs	1075	7	class	class	NN
cord-296347-fanlvxqs	1076	1	I	-PRON-	PRP
cord-296347-fanlvxqs	1076	2	ubiquitination	ubiquitination	IN
cord-296347-fanlvxqs	1076	3	by	by	IN
cord-296347-fanlvxqs	1076	4	a	a	DT
cord-296347-fanlvxqs	1076	5	viral	viral	JJ
cord-296347-fanlvxqs	1076	6	PHD	PHD	NNP
cord-296347-fanlvxqs	1076	7	/	/	SYM
cord-296347-fanlvxqs	1076	8	LAP	LAP	NNP
cord-296347-fanlvxqs	1076	9	finger	finger	NN
cord-296347-fanlvxqs	1076	10	protein	protein	NN
cord-296347-fanlvxqs	1076	11	Signals	signal	NNS
cord-296347-fanlvxqs	1076	12	for	for	IN
cord-296347-fanlvxqs	1076	13	sorting	sorting	NN
cord-296347-fanlvxqs	1076	14	of	of	IN
cord-296347-fanlvxqs	1076	15	transmembrane	transmembrane	NN
cord-296347-fanlvxqs	1076	16	proteins	protein	NNS
cord-296347-fanlvxqs	1076	17	to	to	IN
cord-296347-fanlvxqs	1076	18	endosomes	endosome	NNS
cord-296347-fanlvxqs	1076	19	and	and	CC
cord-296347-fanlvxqs	1076	20	lysosomes	lysosome	NNS
cord-296347-fanlvxqs	1076	21	Transcriptional	Transcriptional	NNP
cord-296347-fanlvxqs	1076	22	regulation	regulation	NN
cord-296347-fanlvxqs	1076	23	of	of	IN
cord-296347-fanlvxqs	1076	24	the	the	DT
cord-296347-fanlvxqs	1076	25	MHC	MHC	NNP
cord-296347-fanlvxqs	1076	26	class	class	NN
cord-296347-fanlvxqs	1076	27	II	II	NNP
cord-296347-fanlvxqs	1076	28	antigen	antigen	NN
cord-296347-fanlvxqs	1076	29	presentation	presentation	NN
cord-296347-fanlvxqs	1076	30	pathway	pathway	NN
cord-296347-fanlvxqs	1076	31	Viral	viral	JJ
cord-296347-fanlvxqs	1076	32	appropriation	appropriation	NN
cord-296347-fanlvxqs	1076	33	of	of	IN
cord-296347-fanlvxqs	1076	34	apoptotic	apoptotic	JJ
cord-296347-fanlvxqs	1076	35	and	and	CC
cord-296347-fanlvxqs	1076	36	NF	nf	NN
cord-296347-fanlvxqs	1076	37	-	-	HYPH
cord-296347-fanlvxqs	1076	38	kappaB	kappaB	NNP
cord-296347-fanlvxqs	1076	39	signaling	signal	VBG
cord-296347-fanlvxqs	1076	40	pathways	pathway	NNS
cord-296347-fanlvxqs	1077	1	Role	role	NN
cord-296347-fanlvxqs	1077	2	of	of	IN
cord-296347-fanlvxqs	1077	3	the	the	DT
cord-296347-fanlvxqs	1077	4	ubiquitinselective	ubiquitinselective	JJ
cord-296347-fanlvxqs	1077	5	CDC48(UFD1	CDC48(UFD1	NNP
cord-296347-fanlvxqs	1077	6	/	/	SYM
cord-296347-fanlvxqs	1077	7	NPL4)chaperone	npl4)chaperone	NN
cord-296347-fanlvxqs	1078	1	(	(	-LRB-
cord-296347-fanlvxqs	1078	2	segregase	segregase	NN
cord-296347-fanlvxqs	1078	3	)	)	-RRB-
cord-296347-fanlvxqs	1079	1	in	in	IN
cord-296347-fanlvxqs	1079	2	ERAD	ERAD	NNP
cord-296347-fanlvxqs	1079	3	of	of	IN
cord-296347-fanlvxqs	1079	4	OLE1	OLE1	NNP
cord-296347-fanlvxqs	1079	5	and	and	CC
cord-296347-fanlvxqs	1079	6	other	other	JJ
cord-296347-fanlvxqs	1079	7	substrates	substrate	NNS
cord-296347-fanlvxqs	1079	8	Human	human	JJ
cord-296347-fanlvxqs	1079	9	pathogen	pathogen	NN
cord-296347-fanlvxqs	1079	10	subversion	subversion	NN
cord-296347-fanlvxqs	1079	11	of	of	IN
cord-296347-fanlvxqs	1079	12	antigen	antigen	NN
cord-296347-fanlvxqs	1079	13	presentation	presentation	NN
cord-296347-fanlvxqs	1079	14	Virus	Virus	NNP
cord-296347-fanlvxqs	1079	15	-	-	HYPH
cord-296347-fanlvxqs	1079	16	host	host	NN
cord-296347-fanlvxqs	1079	17	interactions	interaction	NNS
cord-296347-fanlvxqs	1079	18	:	:	:
cord-296347-fanlvxqs	1079	19	New	new	JJ
cord-296347-fanlvxqs	1079	20	insights	insight	NNS
cord-296347-fanlvxqs	1079	21	from	from	IN
cord-296347-fanlvxqs	1079	22	the	the	DT
cord-296347-fanlvxqs	1079	23	small	small	JJ
cord-296347-fanlvxqs	1079	24	RNA	RNA	NNP
cord-296347-fanlvxqs	1079	25	world	world	NN
cord-296347-fanlvxqs	1079	26	Class	Class	NNP
cord-296347-fanlvxqs	1079	27	II	II	NNP
cord-296347-fanlvxqs	1079	28	MHC	MHC	NNP
cord-296347-fanlvxqs	1079	29	peptide	peptide	NN
cord-296347-fanlvxqs	1079	30	loading	loading	NN
cord-296347-fanlvxqs	1079	31	by	by	IN
cord-296347-fanlvxqs	1079	32	the	the	DT
cord-296347-fanlvxqs	1079	33	professionals	professional	NNS
cord-296347-fanlvxqs	1079	34	A	a	DT
cord-296347-fanlvxqs	1079	35	genome	genome	NN
cord-296347-fanlvxqs	1079	36	-	-	HYPH
cord-296347-fanlvxqs	1079	37	wide	wide	JJ
cord-296347-fanlvxqs	1079	38	screen	screen	NN
cord-296347-fanlvxqs	1079	39	identifies	identify	VBZ
cord-296347-fanlvxqs	1079	40	Yos9p	yos9p	PRP
cord-296347-fanlvxqs	1079	41	as	as	IN
cord-296347-fanlvxqs	1079	42	essential	essential	JJ
cord-296347-fanlvxqs	1079	43	for	for	IN
cord-296347-fanlvxqs	1079	44	ER	ER	NNP
cord-296347-fanlvxqs	1079	45	-	-	HYPH
cord-296347-fanlvxqs	1079	46	associated	associate	VBN
cord-296347-fanlvxqs	1079	47	degradation	degradation	NN
cord-296347-fanlvxqs	1079	48	of	of	IN
cord-296347-fanlvxqs	1079	49	glycoproteins	glycoprotein	NNS
cord-296347-fanlvxqs	1079	50	Drosophila	Drosophila	NNP
cord-296347-fanlvxqs	1079	51	Signal	Signal	NNP
cord-296347-fanlvxqs	1079	52	peptide	peptide	NN
cord-296347-fanlvxqs	1079	53	peptidase	peptidase	NN
cord-296347-fanlvxqs	1079	54	is	be	VBZ
cord-296347-fanlvxqs	1079	55	an	an	DT
cord-296347-fanlvxqs	1079	56	essential	essential	JJ
cord-296347-fanlvxqs	1079	57	protease	protease	NN
cord-296347-fanlvxqs	1079	58	for	for	IN
cord-296347-fanlvxqs	1079	59	larval	larval	JJ
cord-296347-fanlvxqs	1079	60	development	development	NN
cord-296347-fanlvxqs	1079	61	T	t	NN
cord-296347-fanlvxqs	1079	62	-	-	HYPH
cord-296347-fanlvxqs	1079	63	cell	cell	NN
cord-296347-fanlvxqs	1079	64	recognition	recognition	NN
cord-296347-fanlvxqs	1079	65	of	of	IN
cord-296347-fanlvxqs	1079	66	melanoma	melanoma	NN
cord-296347-fanlvxqs	1079	67	-	-	HYPH
cord-296347-fanlvxqs	1079	68	associated	associate	VBN
cord-296347-fanlvxqs	1079	69	antigens	antigen	NNS
cord-296347-fanlvxqs	1079	70	Endosomal	Endosomal	NNP
cord-296347-fanlvxqs	1079	71	proteases	protease	NNS
cord-296347-fanlvxqs	1079	72	in	in	IN
cord-296347-fanlvxqs	1079	73	antigen	antigen	NN
cord-296347-fanlvxqs	1079	74	presentation	presentation	NN
cord-296347-fanlvxqs	1079	75	Binding	Binding	NNP
cord-296347-fanlvxqs	1079	76	of	of	IN
cord-296347-fanlvxqs	1079	77	human	human	JJ
cord-296347-fanlvxqs	1079	78	cytomegalovirus	cytomegalovirus	NN
cord-296347-fanlvxqs	1079	79	US2	US2	NNP
cord-296347-fanlvxqs	1079	80	to	to	IN
cord-296347-fanlvxqs	1079	81	major	major	JJ
cord-296347-fanlvxqs	1079	82	histocompatibility	histocompatibility	NN
cord-296347-fanlvxqs	1079	83	complex	complex	JJ
cord-296347-fanlvxqs	1079	84	class	class	NN
cord-296347-fanlvxqs	1079	85	I	i	NN
cord-296347-fanlvxqs	1079	86	and	and	CC
cord-296347-fanlvxqs	1079	87	II	II	NNP
cord-296347-fanlvxqs	1079	88	proteins	protein	NNS
cord-296347-fanlvxqs	1079	89	is	be	VBZ
cord-296347-fanlvxqs	1079	90	not	not	RB
cord-296347-fanlvxqs	1079	91	sufficient	sufficient	JJ
cord-296347-fanlvxqs	1079	92	for	for	IN
cord-296347-fanlvxqs	1079	93	their	-PRON-	PRP$
cord-296347-fanlvxqs	1079	94	degradation	degradation	NN
cord-296347-fanlvxqs	1079	95	Hepatitis	Hepatitis	NNP
cord-296347-fanlvxqs	1079	96	C	C	NNP
cord-296347-fanlvxqs	1079	97	virus	virus	NN
cord-296347-fanlvxqs	1079	98	core	core	NN
cord-296347-fanlvxqs	1079	99	protein	protein	NN
cord-296347-fanlvxqs	1079	100	modulates	modulate	VBZ
cord-296347-fanlvxqs	1079	101	TRAIL	TRAIL	NNP
cord-296347-fanlvxqs	1079	102	-	-	HYPH
cord-296347-fanlvxqs	1079	103	mediated	mediate	VBN
cord-296347-fanlvxqs	1079	104	apoptosis	apoptosis	NN
cord-296347-fanlvxqs	1079	105	by	by	IN
cord-296347-fanlvxqs	1079	106	enhancing	enhance	VBG
cord-296347-fanlvxqs	1079	107	Bid	Bid	NNP
cord-296347-fanlvxqs	1079	108	cleavage	cleavage	NN
cord-296347-fanlvxqs	1079	109	and	and	CC
cord-296347-fanlvxqs	1079	110	activation	activation	NN
cord-296347-fanlvxqs	1079	111	of	of	IN
cord-296347-fanlvxqs	1079	112	mitochondria	mitochondrion	NNS
cord-296347-fanlvxqs	1080	1	apoptosis	apoptosis	NN
cord-296347-fanlvxqs	1080	2	signaling	signal	VBG
cord-296347-fanlvxqs	1080	3	pathway	pathway	NN
cord-296347-fanlvxqs	1080	4	Hrs	Hrs	NNP
cord-296347-fanlvxqs	1080	5	function	function	NN
cord-296347-fanlvxqs	1081	1	:	:	:
cord-296347-fanlvxqs	1081	2	Viruses	virus	NNS
cord-296347-fanlvxqs	1081	3	provide	provide	VBP
cord-296347-fanlvxqs	1081	4	the	the	DT
cord-296347-fanlvxqs	1081	5	clue	clue	NN
cord-296347-fanlvxqs	1081	6	Cutting	cut	VBG
cord-296347-fanlvxqs	1081	7	edge	edge	NN
cord-296347-fanlvxqs	1081	8	:	:	:
cord-296347-fanlvxqs	1081	9	Bacterial	bacterial	JJ
cord-296347-fanlvxqs	1081	10	modulation	modulation	NN
cord-296347-fanlvxqs	1081	11	of	of	IN
cord-296347-fanlvxqs	1081	12	epithelial	epithelial	JJ
cord-296347-fanlvxqs	1081	13	signaling	signal	VBG
cord-296347-fanlvxqs	1081	14	via	via	IN
cord-296347-fanlvxqs	1081	15	changes	change	NNS
cord-296347-fanlvxqs	1081	16	in	in	IN
cord-296347-fanlvxqs	1081	17	neddylation	neddylation	NN
cord-296347-fanlvxqs	1081	18	of	of	IN
cord-296347-fanlvxqs	1081	19	cullin-1	cullin-1	NNP
cord-296347-fanlvxqs	1082	1	The	the	DT
cord-296347-fanlvxqs	1082	2	poxviral	poxviral	JJ
cord-296347-fanlvxqs	1082	3	scrapin	scrapin	NNP
cord-296347-fanlvxqs	1082	4	MV	MV	NNP
cord-296347-fanlvxqs	1082	5	-	-	HYPH
cord-296347-fanlvxqs	1082	6	LAP	LAP	NNP
cord-296347-fanlvxqs	1082	7	requires	require	VBZ
cord-296347-fanlvxqs	1082	8	a	a	DT
cord-296347-fanlvxqs	1082	9	myxoma	myxoma	NN
cord-296347-fanlvxqs	1082	10	viral	viral	JJ
cord-296347-fanlvxqs	1082	11	infection	infection	NN
cord-296347-fanlvxqs	1082	12	context	context	NN
cord-296347-fanlvxqs	1082	13	to	to	TO
cord-296347-fanlvxqs	1082	14	efficiently	efficiently	RB
cord-296347-fanlvxqs	1082	15	downregulate	downregulate	VB
cord-296347-fanlvxqs	1082	16	MHC	MHC	NNP
cord-296347-fanlvxqs	1083	1	-I	-i	DT
cord-296347-fanlvxqs	1083	2	molecules	molecule	NNS
cord-296347-fanlvxqs	1084	1	The	the	DT
cord-296347-fanlvxqs	1084	2	co	co	JJ
cord-296347-fanlvxqs	1084	3	-	-	JJ
cord-296347-fanlvxqs	1084	4	chaperone	chaperone	JJ
cord-296347-fanlvxqs	1084	5	CHIP	chip	NN
cord-296347-fanlvxqs	1084	6	regulates	regulate	VBZ
cord-296347-fanlvxqs	1084	7	protein	protein	NN
cord-296347-fanlvxqs	1084	8	triage	triage	NN
cord-296347-fanlvxqs	1084	9	decisions	decision	NNS
cord-296347-fanlvxqs	1084	10	mediated	mediate	VBN
cord-296347-fanlvxqs	1084	11	by	by	IN
cord-296347-fanlvxqs	1084	12	heat	heat	NN
cord-296347-fanlvxqs	1084	13	-	-	HYPH
cord-296347-fanlvxqs	1084	14	shock	shock	NN
cord-296347-fanlvxqs	1084	15	proteins	protein	NNS
cord-296347-fanlvxqs	1085	1	Kaposi	Kaposi	NNP
cord-296347-fanlvxqs	1085	2	's	's	POS
cord-296347-fanlvxqs	1085	3	sarcoma	sarcoma	NN
cord-296347-fanlvxqs	1085	4	-	-	HYPH
cord-296347-fanlvxqs	1085	5	associated	associate	VBN
cord-296347-fanlvxqs	1085	6	herpesvirus	herpesvirus	NN
cord-296347-fanlvxqs	1085	7	encodes	encode	VBZ
cord-296347-fanlvxqs	1085	8	two	two	CD
cord-296347-fanlvxqs	1085	9	proteins	protein	NNS
cord-296347-fanlvxqs	1085	10	that	that	WDT
cord-296347-fanlvxqs	1085	11	block	block	VBP
cord-296347-fanlvxqs	1085	12	cell	cell	NN
cord-296347-fanlvxqs	1085	13	surface	surface	NN
cord-296347-fanlvxqs	1085	14	display	display	NN
cord-296347-fanlvxqs	1085	15	of	of	IN
cord-296347-fanlvxqs	1085	16	MHC	MHC	NNP
cord-296347-fanlvxqs	1085	17	class	class	NN
cord-296347-fanlvxqs	1085	18	I	-PRON-	PRP
cord-296347-fanlvxqs	1085	19	chains	chain	NNS
cord-296347-fanlvxqs	1085	20	by	by	IN
cord-296347-fanlvxqs	1085	21	enhancing	enhance	VBG
cord-296347-fanlvxqs	1085	22	their	-PRON-	PRP$
cord-296347-fanlvxqs	1085	23	endocytosis	endocytosis	NN
cord-296347-fanlvxqs	1085	24	PHD	PHD	NNP
cord-296347-fanlvxqs	1085	25	domains	domain	NNS
cord-296347-fanlvxqs	1085	26	and	and	CC
cord-296347-fanlvxqs	1085	27	E3	e3	NN
cord-296347-fanlvxqs	1085	28	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1085	29	ligases	ligase	NNS
cord-296347-fanlvxqs	1085	30	:	:	:
cord-296347-fanlvxqs	1085	31	Viruses	virus	NNS
cord-296347-fanlvxqs	1085	32	make	make	VBP
cord-296347-fanlvxqs	1085	33	the	the	DT
cord-296347-fanlvxqs	1085	34	connection	connection	NN
cord-296347-fanlvxqs	1085	35	A	a	DT
cord-296347-fanlvxqs	1085	36	novel	novel	JJ
cord-296347-fanlvxqs	1085	37	class	class	NN
cord-296347-fanlvxqs	1085	38	of	of	IN
cord-296347-fanlvxqs	1085	39	herpesvirus	herpesvirus	NN
cord-296347-fanlvxqs	1085	40	-	-	HYPH
cord-296347-fanlvxqs	1085	41	encoded	encode	VBN
cord-296347-fanlvxqs	1085	42	membrane	membrane	NN
cord-296347-fanlvxqs	1085	43	-	-	HYPH
cord-296347-fanlvxqs	1085	44	bound	bind	VBN
cord-296347-fanlvxqs	1085	45	E3	e3	NN
cord-296347-fanlvxqs	1085	46	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1085	47	ligases	ligase	NNS
cord-296347-fanlvxqs	1085	48	regulates	regulate	VBZ
cord-296347-fanlvxqs	1085	49	endocytosis	endocytosis	NN
cord-296347-fanlvxqs	1085	50	of	of	IN
cord-296347-fanlvxqs	1085	51	proteins	protein	NNS
cord-296347-fanlvxqs	1085	52	involved	involve	VBN
cord-296347-fanlvxqs	1085	53	in	in	IN
cord-296347-fanlvxqs	1085	54	immune	immune	JJ
cord-296347-fanlvxqs	1085	55	recognition	recognition	NN
cord-296347-fanlvxqs	1086	1	A	a	DT
cord-296347-fanlvxqs	1086	2	novel	novel	JJ
cord-296347-fanlvxqs	1086	3	immunoglobulin	immunoglobulin	NN
cord-296347-fanlvxqs	1086	4	superfamily	superfamily	NN
cord-296347-fanlvxqs	1086	5	receptor	receptor	NN
cord-296347-fanlvxqs	1086	6	for	for	IN
cord-296347-fanlvxqs	1086	7	cellular	cellular	JJ
cord-296347-fanlvxqs	1086	8	and	and	CC
cord-296347-fanlvxqs	1086	9	viral	viral	JJ
cord-296347-fanlvxqs	1086	10	MHC	MHC	NNP
cord-296347-fanlvxqs	1086	11	class	class	NN
cord-296347-fanlvxqs	1087	1	I	-PRON-	PRP
cord-296347-fanlvxqs	1087	2	molecules	molecule	VBZ
cord-296347-fanlvxqs	1087	3	A	a	DT
cord-296347-fanlvxqs	1087	4	misassembled	misassembled	JJ
cord-296347-fanlvxqs	1087	5	transmembrane	transmembrane	NN
cord-296347-fanlvxqs	1087	6	domain	domain	NN
cord-296347-fanlvxqs	1087	7	of	of	IN
cord-296347-fanlvxqs	1087	8	a	a	DT
cord-296347-fanlvxqs	1087	9	polytopic	polytopic	NNP
cord-296347-fanlvxqs	1087	10	protein	protein	NNP
cord-296347-fanlvxqs	1087	11	associates	associate	NNS
cord-296347-fanlvxqs	1087	12	with	with	IN
cord-296347-fanlvxqs	1087	13	signal	signal	NN
cord-296347-fanlvxqs	1087	14	peptide	peptide	NN
cord-296347-fanlvxqs	1087	15	peptidase	peptidase	NN
cord-296347-fanlvxqs	1087	16	Assembly	Assembly	NNP
cord-296347-fanlvxqs	1087	17	,	,	,
cord-296347-fanlvxqs	1087	18	transport	transport	NN
cord-296347-fanlvxqs	1087	19	,	,	,
cord-296347-fanlvxqs	1087	20	and	and	CC
cord-296347-fanlvxqs	1087	21	function	function	NN
cord-296347-fanlvxqs	1087	22	of	of	IN
cord-296347-fanlvxqs	1087	23	MHC	MHC	NNP
cord-296347-fanlvxqs	1087	24	class	class	NN
cord-296347-fanlvxqs	1087	25	II	II	NNP
cord-296347-fanlvxqs	1087	26	molecules	molecule	NNS
cord-296347-fanlvxqs	1087	27	Mechanisms	Mechanisms	NNPS
cord-296347-fanlvxqs	1087	28	of	of	IN
cord-296347-fanlvxqs	1087	29	MHC	MHC	NNP
cord-296347-fanlvxqs	1087	30	class	class	NN
cord-296347-fanlvxqs	1087	31	I	i	NN
cord-296347-fanlvxqs	1087	32	-	-	HYPH
cord-296347-fanlvxqs	1087	33	restricted	restrict	VBN
cord-296347-fanlvxqs	1087	34	antigen	antigen	NN
cord-296347-fanlvxqs	1087	35	processing	processing	NN
cord-296347-fanlvxqs	1087	36	and	and	CC
cord-296347-fanlvxqs	1087	37	cross	cross	JJ
cord-296347-fanlvxqs	1087	38	-	-	JJ
cord-296347-fanlvxqs	1087	39	presentation	presentation	JJ
cord-296347-fanlvxqs	1087	40	Human	human	JJ
cord-296347-fanlvxqs	1087	41	immunodeficiency	immunodeficiency	NN
cord-296347-fanlvxqs	1087	42	virus	virus	NN
cord-296347-fanlvxqs	1087	43	type	type	NN
cord-296347-fanlvxqs	1087	44	1	1	CD
cord-296347-fanlvxqs	1087	45	glycoprotein	glycoprotein	NN
cord-296347-fanlvxqs	1087	46	precursor	precursor	NN
cord-296347-fanlvxqs	1088	1	retains	retain	VBZ
cord-296347-fanlvxqs	1088	2	a	a	DT
cord-296347-fanlvxqs	1088	3	CD4-p56lck	cd4-p56lck	NN
cord-296347-fanlvxqs	1088	4	complex	complex	NN
cord-296347-fanlvxqs	1088	5	in	in	IN
cord-296347-fanlvxqs	1088	6	the	the	DT
cord-296347-fanlvxqs	1088	7	endoplasmic	endoplasmic	NN
cord-296347-fanlvxqs	1088	8	reticulum	reticulum	NN
cord-296347-fanlvxqs	1088	9	Immunological	immunological	JJ
cord-296347-fanlvxqs	1088	10	memory	memory	NN
cord-296347-fanlvxqs	1088	11	in	in	IN
cord-296347-fanlvxqs	1088	12	humans	human	NNS
cord-296347-fanlvxqs	1088	13	Deubiquitinating	Deubiquitinating	NNP
cord-296347-fanlvxqs	1088	14	enzymes	enzyme	NNS
cord-296347-fanlvxqs	1088	15	:	:	:
cord-296347-fanlvxqs	1088	16	A	a	DT
cord-296347-fanlvxqs	1088	17	new	new	JJ
cord-296347-fanlvxqs	1088	18	class	class	NN
cord-296347-fanlvxqs	1088	19	of	of	IN
cord-296347-fanlvxqs	1088	20	biological	biological	JJ
cord-296347-fanlvxqs	1088	21	regulators	regulator	NNS
cord-296347-fanlvxqs	1088	22	E3	E3	NNP
cord-296347-fanlvxqs	1088	23	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1088	24	ligases	ligase	NNS
cord-296347-fanlvxqs	1088	25	as	as	IN
cord-296347-fanlvxqs	1088	26	regulators	regulator	NNS
cord-296347-fanlvxqs	1088	27	of	of	IN
cord-296347-fanlvxqs	1088	28	membrane	membrane	NN
cord-296347-fanlvxqs	1088	29	protein	protein	NN
cord-296347-fanlvxqs	1088	30	trafficking	trafficking	NN
cord-296347-fanlvxqs	1088	31	and	and	CC
cord-296347-fanlvxqs	1088	32	degradation	degradation	NN
cord-296347-fanlvxqs	1088	33	ISG15	isg15	NN
cord-296347-fanlvxqs	1088	34	:	:	:
cord-296347-fanlvxqs	1089	1	A	a	DT
cord-296347-fanlvxqs	1089	2	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1089	3	-	-	HYPH
cord-296347-fanlvxqs	1089	4	like	like	JJ
cord-296347-fanlvxqs	1089	5	enigma	enigma	NN
cord-296347-fanlvxqs	1090	1	Herc5	Herc5	NNP
cord-296347-fanlvxqs	1090	2	,	,	,
cord-296347-fanlvxqs	1090	3	an	an	DT
cord-296347-fanlvxqs	1090	4	interferon	interferon	NN
cord-296347-fanlvxqs	1090	5	-	-	HYPH
cord-296347-fanlvxqs	1090	6	induced	induce	VBN
cord-296347-fanlvxqs	1090	7	HECT	HECT	NNP
cord-296347-fanlvxqs	1090	8	E3	E3	NNP
cord-296347-fanlvxqs	1090	9	enzyme	enzyme	NN
cord-296347-fanlvxqs	1090	10	,	,	,
cord-296347-fanlvxqs	1090	11	is	be	VBZ
cord-296347-fanlvxqs	1090	12	required	require	VBN
cord-296347-fanlvxqs	1090	13	for	for	IN
cord-296347-fanlvxqs	1090	14	conjugation	conjugation	NN
cord-296347-fanlvxqs	1090	15	of	of	IN
cord-296347-fanlvxqs	1090	16	ISG15	isg15	NN
cord-296347-fanlvxqs	1090	17	in	in	IN
cord-296347-fanlvxqs	1090	18	human	human	JJ
cord-296347-fanlvxqs	1090	19	cells	cell	NNS
cord-296347-fanlvxqs	1090	20	Binding	bind	VBG
cord-296347-fanlvxqs	1090	21	of	of	IN
cord-296347-fanlvxqs	1090	22	Cdc48p	Cdc48p	NNP
cord-296347-fanlvxqs	1090	23	to	to	IN
cord-296347-fanlvxqs	1090	24	a	a	DT
cord-296347-fanlvxqs	1090	25	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1090	26	-	-	HYPH
cord-296347-fanlvxqs	1090	27	related	relate	VBN
cord-296347-fanlvxqs	1090	28	UBX	UBX	NNP
cord-296347-fanlvxqs	1090	29	domain	domain	NN
cord-296347-fanlvxqs	1090	30	from	from	IN
cord-296347-fanlvxqs	1090	31	novel	novel	JJ
cord-296347-fanlvxqs	1090	32	yeast	yeast	NN
cord-296347-fanlvxqs	1090	33	proteins	protein	NNS
cord-296347-fanlvxqs	1090	34	involved	involve	VBN
cord-296347-fanlvxqs	1090	35	in	in	IN
cord-296347-fanlvxqs	1090	36	intracellular	intracellular	JJ
cord-296347-fanlvxqs	1090	37	proteolysis	proteolysis	NN
cord-296347-fanlvxqs	1090	38	and	and	CC
cord-296347-fanlvxqs	1090	39	sporulation	sporulation	NN
cord-296347-fanlvxqs	1090	40	RNA	RNA	NNP
cord-296347-fanlvxqs	1090	41	silencing	silencing	NN
cord-296347-fanlvxqs	1090	42	:	:	:
cord-296347-fanlvxqs	1091	1	A	a	DT
cord-296347-fanlvxqs	1091	2	conserved	conserved	JJ
cord-296347-fanlvxqs	1091	3	antiviral	antiviral	JJ
cord-296347-fanlvxqs	1091	4	immunity	immunity	NN
cord-296347-fanlvxqs	1091	5	of	of	IN
cord-296347-fanlvxqs	1091	6	plants	plant	NNS
cord-296347-fanlvxqs	1091	7	and	and	CC
cord-296347-fanlvxqs	1091	8	animals	animal	NNS
cord-296347-fanlvxqs	1091	9	p97	p97	CD
cord-296347-fanlvxqs	1091	10	and	and	CC
cord-296347-fanlvxqs	1091	11	close	close	JJ
cord-296347-fanlvxqs	1091	12	encounters	encounter	NNS
cord-296347-fanlvxqs	1091	13	of	of	IN
cord-296347-fanlvxqs	1091	14	every	every	DT
cord-296347-fanlvxqs	1091	15	kind	kind	NN
cord-296347-fanlvxqs	1091	16	:	:	:
cord-296347-fanlvxqs	1091	17	A	a	DT
cord-296347-fanlvxqs	1091	18	brief	brief	JJ
cord-296347-fanlvxqs	1091	19	review	review	NN
cord-296347-fanlvxqs	1091	20	Lysine-63-linked	lysine-63-linke	VBN
cord-296347-fanlvxqs	1091	21	ubiquitination	ubiquitination	NN
cord-296347-fanlvxqs	1091	22	is	be	VBZ
cord-296347-fanlvxqs	1091	23	required	require	VBN
cord-296347-fanlvxqs	1091	24	for	for	IN
cord-296347-fanlvxqs	1091	25	endolysosomal	endolysosomal	JJ
cord-296347-fanlvxqs	1091	26	degradation	degradation	NN
cord-296347-fanlvxqs	1091	27	of	of	IN
cord-296347-fanlvxqs	1091	28	class	class	NN
cord-296347-fanlvxqs	1092	1	I	-PRON-	PRP
cord-296347-fanlvxqs	1092	2	molecules	molecule	NNS
cord-296347-fanlvxqs	1093	1	Human	human	JJ
cord-296347-fanlvxqs	1093	2	cytomegalovirus	cytomegalovirus	NN
cord-296347-fanlvxqs	1093	3	glycoprotein	glycoprotein	NN
cord-296347-fanlvxqs	1093	4	UL16	UL16	NNP
cord-296347-fanlvxqs	1093	5	causes	cause	VBZ
cord-296347-fanlvxqs	1093	6	intracellular	intracellular	JJ
cord-296347-fanlvxqs	1093	7	sequestration	sequestration	NN
cord-296347-fanlvxqs	1093	8	of	of	IN
cord-296347-fanlvxqs	1093	9	NKG2D	nkg2d	NN
cord-296347-fanlvxqs	1093	10	ligands	ligand	NNS
cord-296347-fanlvxqs	1093	11	,	,	,
cord-296347-fanlvxqs	1093	12	protecting	protect	VBG
cord-296347-fanlvxqs	1093	13	against	against	IN
cord-296347-fanlvxqs	1093	14	natural	natural	JJ
cord-296347-fanlvxqs	1093	15	killer	killer	NN
cord-296347-fanlvxqs	1093	16	cell	cell	NN
cord-296347-fanlvxqs	1093	17	cytotoxicity	cytotoxicity	NN
cord-296347-fanlvxqs	1093	18	Quality	Quality	NNP
cord-296347-fanlvxqs	1093	19	control	control	NN
cord-296347-fanlvxqs	1093	20	in	in	IN
cord-296347-fanlvxqs	1093	21	the	the	DT
cord-296347-fanlvxqs	1093	22	endoplasmic	endoplasmic	NN
cord-296347-fanlvxqs	1093	23	reticulum	reticulum	NN
cord-296347-fanlvxqs	1093	24	Rad23	Rad23	NNP
cord-296347-fanlvxqs	1093	25	and	and	CC
cord-296347-fanlvxqs	1093	26	Rpn10	Rpn10	NNP
cord-296347-fanlvxqs	1093	27	serve	serve	VBP
cord-296347-fanlvxqs	1093	28	as	as	IN
cord-296347-fanlvxqs	1093	29	alternative	alternative	JJ
cord-296347-fanlvxqs	1093	30	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1093	31	receptors	receptor	NNS
cord-296347-fanlvxqs	1093	32	for	for	IN
cord-296347-fanlvxqs	1093	33	the	the	DT
cord-296347-fanlvxqs	1093	34	proteasome	proteasome	VBN
cord-296347-fanlvxqs	1093	35	EDEM	EDEM	NNP
cord-296347-fanlvxqs	1093	36	contributes	contribute	VBZ
cord-296347-fanlvxqs	1093	37	to	to	IN
cord-296347-fanlvxqs	1093	38	maintenance	maintenance	NN
cord-296347-fanlvxqs	1093	39	of	of	IN
cord-296347-fanlvxqs	1093	40	protein	protein	NN
cord-296347-fanlvxqs	1093	41	folding	folding	NN
cord-296347-fanlvxqs	1093	42	efficiency	efficiency	NN
cord-296347-fanlvxqs	1093	43	and	and	CC
cord-296347-fanlvxqs	1093	44	secretory	secretory	NN
cord-296347-fanlvxqs	1093	45	capacity	capacity	NN
cord-296347-fanlvxqs	1094	1	Presenilin	Presenilin	NNP
cord-296347-fanlvxqs	1094	2	1	1	CD
cord-296347-fanlvxqs	1094	3	mediates	mediate	VBZ
cord-296347-fanlvxqs	1094	4	the	the	DT
cord-296347-fanlvxqs	1094	5	turnover	turnover	NN
cord-296347-fanlvxqs	1094	6	of	of	IN
cord-296347-fanlvxqs	1094	7	telencephalin	telencephalin	DT
cord-296347-fanlvxqs	1094	8	in	in	IN
cord-296347-fanlvxqs	1094	9	hippocampal	hippocampal	JJ
cord-296347-fanlvxqs	1094	10	neurons	neuron	NNS
cord-296347-fanlvxqs	1094	11	via	via	IN
cord-296347-fanlvxqs	1094	12	an	an	DT
cord-296347-fanlvxqs	1094	13	autophagic	autophagic	NNP
cord-296347-fanlvxqs	1094	14	degradative	degradative	JJ
cord-296347-fanlvxqs	1094	15	pathway	pathway	NN
cord-296347-fanlvxqs	1094	16	NK	NK	NNP
cord-296347-fanlvxqs	1094	17	cell	cell	NN
cord-296347-fanlvxqs	1094	18	activity	activity	NN
cord-296347-fanlvxqs	1094	19	during	during	IN
cord-296347-fanlvxqs	1094	20	human	human	JJ
cord-296347-fanlvxqs	1094	21	cytomegalovirus	cytomegalovirus	NN
cord-296347-fanlvxqs	1094	22	infection	infection	NN
cord-296347-fanlvxqs	1094	23	is	be	VBZ
cord-296347-fanlvxqs	1094	24	dominated	dominate	VBN
cord-296347-fanlvxqs	1094	25	by	by	IN
cord-296347-fanlvxqs	1094	26	US2	US2	NNP
cord-296347-fanlvxqs	1094	27	-	-	HYPH
cord-296347-fanlvxqs	1094	28	11-mediated	11-mediated	CD
cord-296347-fanlvxqs	1094	29	HLA	HLA	NNP
cord-296347-fanlvxqs	1094	30	class	class	NN
cord-296347-fanlvxqs	1095	1	I	-PRON-	PRP
cord-296347-fanlvxqs	1095	2	down	down	RB
cord-296347-fanlvxqs	1095	3	-	-	HYPH
cord-296347-fanlvxqs	1095	4	regulation	regulation	NN
cord-296347-fanlvxqs	1096	1	The	the	DT
cord-296347-fanlvxqs	1096	2	tumor	tumor	NN
cord-296347-fanlvxqs	1096	3	autocrine	autocrine	NN
cord-296347-fanlvxqs	1096	4	motility	motility	NN
cord-296347-fanlvxqs	1096	5	factor	factor	NN
cord-296347-fanlvxqs	1096	6	receptor	receptor	NN
cord-296347-fanlvxqs	1096	7	,	,	,
cord-296347-fanlvxqs	1096	8	gp78	gp78	NNP
cord-296347-fanlvxqs	1096	9	,	,	,
cord-296347-fanlvxqs	1096	10	is	be	VBZ
cord-296347-fanlvxqs	1096	11	a	a	DT
cord-296347-fanlvxqs	1096	12	ubiquitin	ubiquitin	JJ
cord-296347-fanlvxqs	1096	13	protein	protein	NN
cord-296347-fanlvxqs	1096	14	ligase	ligase	NN
cord-296347-fanlvxqs	1096	15	implicated	implicate	VBN
cord-296347-fanlvxqs	1096	16	in	in	IN
cord-296347-fanlvxqs	1096	17	degradation	degradation	NN
cord-296347-fanlvxqs	1096	18	from	from	IN
cord-296347-fanlvxqs	1096	19	the	the	DT
cord-296347-fanlvxqs	1096	20	endoplasmic	endoplasmic	NN
cord-296347-fanlvxqs	1096	21	reticulum	reticulum	NN
cord-296347-fanlvxqs	1096	22	Cytomegalovirus	Cytomegalovirus	NNP
cord-296347-fanlvxqs	1096	23	MHC	MHC	NNP
cord-296347-fanlvxqs	1096	24	class	class	NN
cord-296347-fanlvxqs	1097	1	I	-PRON-	PRP
cord-296347-fanlvxqs	1097	2	homologues	homologue	NNS
cord-296347-fanlvxqs	1097	3	and	and	CC
cord-296347-fanlvxqs	1097	4	natural	natural	JJ
cord-296347-fanlvxqs	1097	5	killer	killer	NN
cord-296347-fanlvxqs	1097	6	cells	cell	NNS
cord-296347-fanlvxqs	1097	7	:	:	:
cord-296347-fanlvxqs	1097	8	An	an	DT
cord-296347-fanlvxqs	1097	9	overview	overview	NN
cord-296347-fanlvxqs	1097	10	Accumulation	accumulation	NN
cord-296347-fanlvxqs	1097	11	of	of	IN
cord-296347-fanlvxqs	1097	12	an	an	DT
cord-296347-fanlvxqs	1097	13	mRNA	mrna	NN
cord-296347-fanlvxqs	1097	14	and	and	CC
cord-296347-fanlvxqs	1097	15	protein	protein	NN
cord-296347-fanlvxqs	1097	16	in	in	IN
cord-296347-fanlvxqs	1097	17	interferon	interferon	NN
cord-296347-fanlvxqs	1097	18	-	-	HYPH
cord-296347-fanlvxqs	1097	19	treated	treat	VBN
cord-296347-fanlvxqs	1097	20	Ehrlich	Ehrlich	NNP
cord-296347-fanlvxqs	1097	21	ascites	ascites	NN
cord-296347-fanlvxqs	1097	22	tumour	tumour	NN
cord-296347-fanlvxqs	1097	23	cells	cell	NNS
cord-296347-fanlvxqs	1098	1	ARF1	ARF1	NNP
cord-296347-fanlvxqs	1098	2	regulates	regulate	VBZ
cord-296347-fanlvxqs	1098	3	Nef	Nef	NNP
cord-296347-fanlvxqs	1098	4	-	-	HYPH
cord-296347-fanlvxqs	1098	5	induced	induce	VBN
cord-296347-fanlvxqs	1098	6	CD4	CD4	NNP
cord-296347-fanlvxqs	1098	7	degradation	degradation	NN
cord-296347-fanlvxqs	1098	8	Anti	Anti	NNP
cord-296347-fanlvxqs	1098	9	-	-	NNP
cord-296347-fanlvxqs	1098	10	immunology	immunology	NN
cord-296347-fanlvxqs	1098	11	:	:	:
cord-296347-fanlvxqs	1099	1	Evasion	evasion	NN
cord-296347-fanlvxqs	1099	2	of	of	IN
cord-296347-fanlvxqs	1099	3	the	the	DT
cord-296347-fanlvxqs	1099	4	host	host	NN
cord-296347-fanlvxqs	1099	5	immune	immune	JJ
cord-296347-fanlvxqs	1099	6	system	system	NN
cord-296347-fanlvxqs	1099	7	by	by	IN
cord-296347-fanlvxqs	1099	8	bacterial	bacterial	JJ
cord-296347-fanlvxqs	1099	9	and	and	CC
cord-296347-fanlvxqs	1099	10	viral	viral	JJ
cord-296347-fanlvxqs	1099	11	pathogens	pathogen	NNS
cord-296347-fanlvxqs	1100	1	Ubiquitin	Ubiquitin	NNP
cord-296347-fanlvxqs	1100	2	as	as	IN
cord-296347-fanlvxqs	1100	3	a	a	DT
cord-296347-fanlvxqs	1100	4	central	central	JJ
cord-296347-fanlvxqs	1100	5	cellular	cellular	JJ
cord-296347-fanlvxqs	1100	6	regulator	regulator	NN
cord-296347-fanlvxqs	1101	1	Polyubiquitin	Polyubiquitin	NNP
cord-296347-fanlvxqs	1101	2	serves	serve	VBZ
cord-296347-fanlvxqs	1101	3	as	as	IN
cord-296347-fanlvxqs	1101	4	a	a	DT
cord-296347-fanlvxqs	1101	5	recognition	recognition	NN
cord-296347-fanlvxqs	1101	6	signal	signal	NN
cord-296347-fanlvxqs	1101	7	,	,	,
cord-296347-fanlvxqs	1101	8	rather	rather	RB
cord-296347-fanlvxqs	1101	9	than	than	IN
cord-296347-fanlvxqs	1101	10	a	a	DT
cord-296347-fanlvxqs	1101	11	ratcheting	ratcheting	NN
cord-296347-fanlvxqs	1101	12	molecule	molecule	NN
cord-296347-fanlvxqs	1101	13	,	,	,
cord-296347-fanlvxqs	1101	14	during	during	IN
cord-296347-fanlvxqs	1101	15	retrotranslocation	retrotranslocation	NN
cord-296347-fanlvxqs	1101	16	of	of	IN
cord-296347-fanlvxqs	1101	17	proteins	protein	NNS
cord-296347-fanlvxqs	1101	18	across	across	IN
cord-296347-fanlvxqs	1101	19	the	the	DT
cord-296347-fanlvxqs	1101	20	endoplasmic	endoplasmic	NN
cord-296347-fanlvxqs	1101	21	reticulum	reticulum	NN
cord-296347-fanlvxqs	1101	22	membrane	membrane	NN
cord-296347-fanlvxqs	1101	23	Gamma	Gamma	NNP
cord-296347-fanlvxqs	1101	24	-	-	HYPH
cord-296347-fanlvxqs	1101	25	secretase	secretase	NN
cord-296347-fanlvxqs	1101	26	-	-	HYPH
cord-296347-fanlvxqs	1101	27	mediated	mediate	VBN
cord-296347-fanlvxqs	1101	28	proteolysis	proteolysis	NN
cord-296347-fanlvxqs	1101	29	in	in	IN
cord-296347-fanlvxqs	1101	30	cell	cell	NN
cord-296347-fanlvxqs	1101	31	-	-	HYPH
cord-296347-fanlvxqs	1101	32	surface	surface	NN
cord-296347-fanlvxqs	1101	33	-	-	HYPH
cord-296347-fanlvxqs	1101	34	receptor	receptor	NN
cord-296347-fanlvxqs	1101	35	signalling	signal	VBG
cord-296347-fanlvxqs	1101	36	Consensus	Consensus	NNP
cord-296347-fanlvxqs	1101	37	analysis	analysis	NN
cord-296347-fanlvxqs	1101	38	of	of	IN
cord-296347-fanlvxqs	1101	39	signal	signal	NN
cord-296347-fanlvxqs	1101	40	peptide	peptide	NN
cord-296347-fanlvxqs	1101	41	peptidase	peptidase	NN
cord-296347-fanlvxqs	1101	42	and	and	CC
cord-296347-fanlvxqs	1101	43	homologous	homologous	JJ
cord-296347-fanlvxqs	1101	44	human	human	JJ
cord-296347-fanlvxqs	1101	45	aspartic	aspartic	JJ
cord-296347-fanlvxqs	1101	46	proteases	protease	NNS
cord-296347-fanlvxqs	1101	47	reveals	reveal	VBZ
cord-296347-fanlvxqs	1101	48	opposite	opposite	JJ
cord-296347-fanlvxqs	1101	49	topology	topology	NN
cord-296347-fanlvxqs	1101	50	of	of	IN
cord-296347-fanlvxqs	1101	51	catalytic	catalytic	JJ
cord-296347-fanlvxqs	1101	52	domains	domain	NNS
cord-296347-fanlvxqs	1101	53	compared	compare	VBN
cord-296347-fanlvxqs	1101	54	with	with	IN
cord-296347-fanlvxqs	1101	55	presenilins	presenilin	NNS
cord-296347-fanlvxqs	1101	56	The	the	DT
cord-296347-fanlvxqs	1101	57	human	human	JJ
cord-296347-fanlvxqs	1101	58	cytomegalovirus	cytomegalovirus	NN
cord-296347-fanlvxqs	1101	59	US10	US10	NNP
cord-296347-fanlvxqs	1101	60	gene	gene	NN
cord-296347-fanlvxqs	1101	61	product	product	NN
cord-296347-fanlvxqs	1101	62	delays	delay	NNS
cord-296347-fanlvxqs	1101	63	trafficking	traffic	VBG
cord-296347-fanlvxqs	1101	64	of	of	IN
cord-296347-fanlvxqs	1101	65	major	major	JJ
cord-296347-fanlvxqs	1101	66	histocompatibility	histocompatibility	NN
cord-296347-fanlvxqs	1101	67	complex	complex	JJ
cord-296347-fanlvxqs	1101	68	class	class	NN
cord-296347-fanlvxqs	1102	1	I	-PRON-	PRP
cord-296347-fanlvxqs	1102	2	molecules	molecule	NNS
cord-296347-fanlvxqs	1103	1	Membrane	membrane	NN
cord-296347-fanlvxqs	1103	2	-	-	HYPH
cord-296347-fanlvxqs	1103	3	specific	specific	JJ
cord-296347-fanlvxqs	1103	4	,	,	,
cord-296347-fanlvxqs	1103	5	host	host	NN
cord-296347-fanlvxqs	1103	6	-	-	HYPH
cord-296347-fanlvxqs	1103	7	derived	derive	VBN
cord-296347-fanlvxqs	1103	8	factors	factor	NNS
cord-296347-fanlvxqs	1103	9	are	be	VBP
cord-296347-fanlvxqs	1103	10	required	require	VBN
cord-296347-fanlvxqs	1103	11	for	for	IN
cord-296347-fanlvxqs	1103	12	US2-and	us2-and	CD
cord-296347-fanlvxqs	1103	13	US11-mediated	us11-mediated	CD
cord-296347-fanlvxqs	1103	14	degradation	degradation	NN
cord-296347-fanlvxqs	1103	15	of	of	IN
cord-296347-fanlvxqs	1103	16	major	major	JJ
cord-296347-fanlvxqs	1103	17	histocompatibility	histocompatibility	NN
cord-296347-fanlvxqs	1103	18	complex	complex	JJ
cord-296347-fanlvxqs	1103	19	class	class	NN
cord-296347-fanlvxqs	1104	1	I	-PRON-	PRP
cord-296347-fanlvxqs	1104	2	molecules	molecule	VBZ
cord-296347-fanlvxqs	1104	3	Ubiquitinylation	Ubiquitinylation	NNP
cord-296347-fanlvxqs	1104	4	of	of	IN
cord-296347-fanlvxqs	1104	5	the	the	DT
cord-296347-fanlvxqs	1104	6	cytosolic	cytosolic	JJ
cord-296347-fanlvxqs	1104	7	domain	domain	NN
cord-296347-fanlvxqs	1104	8	of	of	IN
cord-296347-fanlvxqs	1104	9	a	a	DT
cord-296347-fanlvxqs	1104	10	type	type	NN
cord-296347-fanlvxqs	1104	11	I	-PRON-	PRP
cord-296347-fanlvxqs	1104	12	membrane	membrane	NN
cord-296347-fanlvxqs	1104	13	protein	protein	NN
cord-296347-fanlvxqs	1104	14	is	be	VBZ
cord-296347-fanlvxqs	1104	15	not	not	RB
cord-296347-fanlvxqs	1104	16	required	require	VBN
cord-296347-fanlvxqs	1104	17	to	to	TO
cord-296347-fanlvxqs	1104	18	initiate	initiate	VB
cord-296347-fanlvxqs	1104	19	its	-PRON-	PRP$
cord-296347-fanlvxqs	1104	20	dislocation	dislocation	NN
cord-296347-fanlvxqs	1104	21	from	from	IN
cord-296347-fanlvxqs	1104	22	the	the	DT
cord-296347-fanlvxqs	1104	23	endoplasmic	endoplasmic	NN
cord-296347-fanlvxqs	1104	24	reticulum	reticulum	NN
cord-296347-fanlvxqs	1104	25	Type	type	NN
cord-296347-fanlvxqs	1104	26	III	III	NNP
cord-296347-fanlvxqs	1104	27	secretion	secretion	NN
cord-296347-fanlvxqs	1104	28	machines	machine	NNS
cord-296347-fanlvxqs	1104	29	:	:	:
cord-296347-fanlvxqs	1104	30	Bacterial	bacterial	JJ
cord-296347-fanlvxqs	1104	31	devices	device	NNS
cord-296347-fanlvxqs	1104	32	for	for	IN
cord-296347-fanlvxqs	1104	33	protein	protein	NN
cord-296347-fanlvxqs	1104	34	delivery	delivery	NN
cord-296347-fanlvxqs	1104	35	into	into	IN
cord-296347-fanlvxqs	1104	36	host	host	NN
cord-296347-fanlvxqs	1104	37	cells	cell	NNS
cord-296347-fanlvxqs	1104	38	Adenovirus	Adenovirus	NNP
cord-296347-fanlvxqs	1104	39	protein	protein	NN
cord-296347-fanlvxqs	1104	40	involved	involve	VBN
cord-296347-fanlvxqs	1104	41	in	in	IN
cord-296347-fanlvxqs	1105	1	virus	virus	NN
cord-296347-fanlvxqs	1105	2	internalization	internalization	NN
cord-296347-fanlvxqs	1105	3	recruits	recruit	VBZ
cord-296347-fanlvxqs	1105	4	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1105	5	-	-	HYPH
cord-296347-fanlvxqs	1105	6	protein	protein	NN
cord-296347-fanlvxqs	1105	7	ligases	ligase	NNS
cord-296347-fanlvxqs	1106	1	All	all	DT
cord-296347-fanlvxqs	1106	2	four	four	CD
cord-296347-fanlvxqs	1106	3	Sendai	Sendai	NNP
cord-296347-fanlvxqs	1106	4	Virus	Virus	NNP
cord-296347-fanlvxqs	1106	5	C	c	NN
cord-296347-fanlvxqs	1106	6	proteins	protein	NNS
cord-296347-fanlvxqs	1106	7	bind	bind	VBP
cord-296347-fanlvxqs	1106	8	Stat1	Stat1	NNS
cord-296347-fanlvxqs	1106	9	,	,	,
cord-296347-fanlvxqs	1106	10	but	but	CC
cord-296347-fanlvxqs	1107	1	only	only	RB
cord-296347-fanlvxqs	1107	2	the	the	DT
cord-296347-fanlvxqs	1107	3	larger	large	JJR
cord-296347-fanlvxqs	1107	4	forms	form	NNS
cord-296347-fanlvxqs	1107	5	also	also	RB
cord-296347-fanlvxqs	1107	6	induce	induce	VBP
cord-296347-fanlvxqs	1107	7	its	-PRON-	PRP$
cord-296347-fanlvxqs	1107	8	mono	mono	NN
cord-296347-fanlvxqs	1107	9	-	-	HYPH
cord-296347-fanlvxqs	1107	10	ubiquitination	ubiquitination	NN
cord-296347-fanlvxqs	1107	11	and	and	CC
cord-296347-fanlvxqs	1107	12	degradation	degradation	NN
cord-296347-fanlvxqs	1107	13	Tsg101	tsg101	ADD
cord-296347-fanlvxqs	1107	14	and	and	CC
cord-296347-fanlvxqs	1107	15	the	the	DT
cord-296347-fanlvxqs	1107	16	vacuolar	vacuolar	NNP
cord-296347-fanlvxqs	1107	17	protein	protein	NN
cord-296347-fanlvxqs	1107	18	sorting	sort	VBG
cord-296347-fanlvxqs	1107	19	pathway	pathway	NN
cord-296347-fanlvxqs	1107	20	are	be	VBP
cord-296347-fanlvxqs	1107	21	essential	essential	JJ
cord-296347-fanlvxqs	1107	22	for	for	IN
cord-296347-fanlvxqs	1107	23	HIV-1	HIV-1	NNP
cord-296347-fanlvxqs	1107	24	budding	bud	VBG
cord-296347-fanlvxqs	1108	1	The	the	DT
cord-296347-fanlvxqs	1108	2	Hrd1p	hrd1p	NN
cord-296347-fanlvxqs	1108	3	ligase	ligase	NN
cord-296347-fanlvxqs	1108	4	complex	complex	JJ
cord-296347-fanlvxqs	1108	5	forms	form	VBZ
cord-296347-fanlvxqs	1108	6	a	a	DT
cord-296347-fanlvxqs	1108	7	linchpin	linchpin	NN
cord-296347-fanlvxqs	1108	8	between	between	IN
cord-296347-fanlvxqs	1108	9	ER	ER	NNP
cord-296347-fanlvxqs	1108	10	-	-	HYPH
cord-296347-fanlvxqs	1108	11	lumenal	lumenal	JJ
cord-296347-fanlvxqs	1108	12	substrate	substrate	NN
cord-296347-fanlvxqs	1108	13	selection	selection	NN
cord-296347-fanlvxqs	1108	14	and	and	CC
cord-296347-fanlvxqs	1109	1	Cdc48p	cdc48p	CD
cord-296347-fanlvxqs	1109	2	recruitment	recruitment	NN
cord-296347-fanlvxqs	1109	3	HIV-1	HIV-1	NNP
cord-296347-fanlvxqs	1109	4	tat	tat	NN
cord-296347-fanlvxqs	1109	5	protein	protein	NN
cord-296347-fanlvxqs	1109	6	modulates	modulate	VBZ
cord-296347-fanlvxqs	1109	7	the	the	DT
cord-296347-fanlvxqs	1109	8	generation	generation	NN
cord-296347-fanlvxqs	1109	9	of	of	IN
cord-296347-fanlvxqs	1109	10	cytotoxic	cytotoxic	JJ
cord-296347-fanlvxqs	1109	11	T	t	NN
cord-296347-fanlvxqs	1109	12	cell	cell	NN
cord-296347-fanlvxqs	1109	13	epitopes	epitope	NNS
cord-296347-fanlvxqs	1109	14	by	by	IN
cord-296347-fanlvxqs	1109	15	modifying	modify	VBG
cord-296347-fanlvxqs	1109	16	proteasome	proteasome	VBN
cord-296347-fanlvxqs	1109	17	composition	composition	NN
cord-296347-fanlvxqs	1109	18	and	and	CC
cord-296347-fanlvxqs	1109	19	enzymatic	enzymatic	JJ
cord-296347-fanlvxqs	1109	20	activity	activity	NN
cord-296347-fanlvxqs	1109	21	Human	human	NN
cord-296347-fanlvxqs	1109	22	cytomegalovirus	cytomegalovirus	NN
cord-296347-fanlvxqs	1109	23	US2	US2	NNP
cord-296347-fanlvxqs	1109	24	endoplasmic	endoplasmic	NN
cord-296347-fanlvxqs	1109	25	reticulum	reticulum	NN
cord-296347-fanlvxqs	1109	26	-	-	HYPH
cord-296347-fanlvxqs	1109	27	lumenal	lumenal	JJ
cord-296347-fanlvxqs	1109	28	domain	domain	NN
cord-296347-fanlvxqs	1110	1	dictates	dictate	VBZ
cord-296347-fanlvxqs	1110	2	association	association	NNP
cord-296347-fanlvxqs	1110	3	with	with	IN
cord-296347-fanlvxqs	1110	4	major	major	JJ
cord-296347-fanlvxqs	1110	5	histocompatibility	histocompatibility	NN
cord-296347-fanlvxqs	1110	6	complex	complex	JJ
cord-296347-fanlvxqs	1110	7	class	class	NN
cord-296347-fanlvxqs	1111	1	I	-PRON-	PRP
cord-296347-fanlvxqs	1111	2	in	in	IN
cord-296347-fanlvxqs	1111	3	a	a	DT
cord-296347-fanlvxqs	1111	4	locus	locus	NN
cord-296347-fanlvxqs	1111	5	-	-	HYPH
cord-296347-fanlvxqs	1111	6	specific	specific	JJ
cord-296347-fanlvxqs	1111	7	manner	manner	NN
cord-296347-fanlvxqs	1111	8	US2	US2	NNP
cord-296347-fanlvxqs	1111	9	,	,	,
cord-296347-fanlvxqs	1111	10	a	a	DT
cord-296347-fanlvxqs	1111	11	human	human	JJ
cord-296347-fanlvxqs	1111	12	cytomegalovirus	cytomegalovirus	NN
cord-296347-fanlvxqs	1111	13	-	-	HYPH
cord-296347-fanlvxqs	1111	14	encoded	encode	VBN
cord-296347-fanlvxqs	1111	15	type	type	NN
cord-296347-fanlvxqs	1111	16	I	-PRON-	PRP
cord-296347-fanlvxqs	1111	17	membrane	membrane	NN
cord-296347-fanlvxqs	1111	18	protein	protein	NN
cord-296347-fanlvxqs	1111	19	,	,	,
cord-296347-fanlvxqs	1111	20	contains	contain	VBZ
cord-296347-fanlvxqs	1112	1	a	a	DT
cord-296347-fanlvxqs	1112	2	non	non	JJ
cord-296347-fanlvxqs	1112	3	-	-	JJ
cord-296347-fanlvxqs	1112	4	cleavable	cleavable	JJ
cord-296347-fanlvxqs	1112	5	amino	amino	NNS
cord-296347-fanlvxqs	1112	6	-	-	HYPH
cord-296347-fanlvxqs	1112	7	terminal	terminal	NN
cord-296347-fanlvxqs	1112	8	signal	signal	NN
cord-296347-fanlvxqs	1112	9	peptide	peptide	NN
cord-296347-fanlvxqs	1112	10	Subunit	Subunit	NNP
cord-296347-fanlvxqs	1112	11	H	H	NNP
cord-296347-fanlvxqs	1112	12	of	of	IN
cord-296347-fanlvxqs	1112	13	the	the	DT
cord-296347-fanlvxqs	1112	14	V	v	NN
cord-296347-fanlvxqs	1112	15	-	-	HYPH
cord-296347-fanlvxqs	1112	16	ATPase	ATPase	NNP
cord-296347-fanlvxqs	1112	17	binds	bind	VBZ
cord-296347-fanlvxqs	1112	18	to	to	IN
cord-296347-fanlvxqs	1112	19	the	the	DT
cord-296347-fanlvxqs	1112	20	medium	medium	JJ
cord-296347-fanlvxqs	1112	21	chain	chain	NN
cord-296347-fanlvxqs	1112	22	of	of	IN
cord-296347-fanlvxqs	1112	23	adaptor	adaptor	NN
cord-296347-fanlvxqs	1112	24	protein	protein	NN
cord-296347-fanlvxqs	1112	25	complex	complex	NN
cord-296347-fanlvxqs	1112	26	2	2	CD
cord-296347-fanlvxqs	1112	27	and	and	CC
cord-296347-fanlvxqs	1112	28	connects	connect	VBZ
cord-296347-fanlvxqs	1112	29	Nef	Nef	NNP
cord-296347-fanlvxqs	1112	30	to	to	IN
cord-296347-fanlvxqs	1112	31	the	the	DT
cord-296347-fanlvxqs	1112	32	endocytic	endocytic	JJ
cord-296347-fanlvxqs	1112	33	machinery	machinery	NN
cord-296347-fanlvxqs	1112	34	Cdc48p	Cdc48p	NNP
cord-296347-fanlvxqs	1112	35	interacts	interact	VBZ
cord-296347-fanlvxqs	1112	36	with	with	IN
cord-296347-fanlvxqs	1112	37	Ufd3p	Ufd3p	NNP
cord-296347-fanlvxqs	1112	38	,	,	,
cord-296347-fanlvxqs	1112	39	a	a	DT
cord-296347-fanlvxqs	1112	40	WD	WD	NNP
cord-296347-fanlvxqs	1112	41	repeat	repeat	NN
cord-296347-fanlvxqs	1112	42	protein	protein	NN
cord-296347-fanlvxqs	1112	43	required	require	VBN
cord-296347-fanlvxqs	1112	44	for	for	IN
cord-296347-fanlvxqs	1112	45	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1112	46	-	-	HYPH
cord-296347-fanlvxqs	1112	47	mediated	mediate	VBN
cord-296347-fanlvxqs	1112	48	proteolysis	proteolysis	NN
cord-296347-fanlvxqs	1112	49	in	in	IN
cord-296347-fanlvxqs	1112	50	Saccharomyces	Saccharomyces	NNP
cord-296347-fanlvxqs	1112	51	cerevisiae	cerevisiae	VBZ
cord-296347-fanlvxqs	1112	52	Proteomic	Proteomic	NNP
cord-296347-fanlvxqs	1112	53	identification	identification	NN
cord-296347-fanlvxqs	1112	54	of	of	IN
cord-296347-fanlvxqs	1112	55	proteins	protein	NNS
cord-296347-fanlvxqs	1112	56	conjugated	conjugate	VBN
cord-296347-fanlvxqs	1112	57	to	to	IN
cord-296347-fanlvxqs	1112	58	ISG15	isg15	NN
cord-296347-fanlvxqs	1112	59	in	in	IN
cord-296347-fanlvxqs	1112	60	mouse	mouse	NN
cord-296347-fanlvxqs	1112	61	and	and	CC
cord-296347-fanlvxqs	1112	62	human	human	NN
cord-296347-fanlvxqs	1112	63	cells	cell	NNS
cord-296347-fanlvxqs	1113	1	Cytomegalovirus	Cytomegalovirus	NNP
cord-296347-fanlvxqs	1113	2	selectively	selectively	RB
cord-296347-fanlvxqs	1113	3	blocks	block	VBZ
cord-296347-fanlvxqs	1113	4	antigen	antigen	NN
cord-296347-fanlvxqs	1113	5	processing	processing	NN
cord-296347-fanlvxqs	1113	6	and	and	CC
cord-296347-fanlvxqs	1113	7	presentation	presentation	NN
cord-296347-fanlvxqs	1113	8	of	of	IN
cord-296347-fanlvxqs	1113	9	its	-PRON-	PRP$
cord-296347-fanlvxqs	1113	10	immediate	immediate	JJ
cord-296347-fanlvxqs	1113	11	-	-	HYPH
cord-296347-fanlvxqs	1113	12	early	early	JJ
cord-296347-fanlvxqs	1113	13	gene	gene	NN
cord-296347-fanlvxqs	1113	14	product	product	NN
cord-296347-fanlvxqs	1114	1	c	c	LS
cord-296347-fanlvxqs	1114	2	-	-	HYPH
cord-296347-fanlvxqs	1114	3	MIR	MIR	NNP
cord-296347-fanlvxqs	1114	4	,	,	,
cord-296347-fanlvxqs	1114	5	a	a	DT
cord-296347-fanlvxqs	1114	6	human	human	JJ
cord-296347-fanlvxqs	1114	7	E3	e3	NN
cord-296347-fanlvxqs	1114	8	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1114	9	ligase	ligase	NN
cord-296347-fanlvxqs	1114	10	,	,	,
cord-296347-fanlvxqs	1114	11	is	be	VBZ
cord-296347-fanlvxqs	1114	12	a	a	DT
cord-296347-fanlvxqs	1114	13	functional	functional	JJ
cord-296347-fanlvxqs	1114	14	homolog	homolog	NN
cord-296347-fanlvxqs	1114	15	of	of	IN
cord-296347-fanlvxqs	1114	16	herpesvirus	herpesvirus	NN
cord-296347-fanlvxqs	1114	17	proteins	protein	VBZ
cord-296347-fanlvxqs	1114	18	MIR1	MIR1	NNP
cord-296347-fanlvxqs	1114	19	and	and	CC
cord-296347-fanlvxqs	1114	20	MIR2	MIR2	NNP
cord-296347-fanlvxqs	1114	21	and	and	CC
cord-296347-fanlvxqs	1114	22	has	have	VBZ
cord-296347-fanlvxqs	1114	23	similar	similar	JJ
cord-296347-fanlvxqs	1114	24	activity	activity	NN
cord-296347-fanlvxqs	1115	1	The	the	DT
cord-296347-fanlvxqs	1115	2	Caenorhabditis	Caenorhabditis	NNP
cord-296347-fanlvxqs	1115	3	elegans	elegan	NNS
cord-296347-fanlvxqs	1115	4	IMPAS	IMPAS	NNP
cord-296347-fanlvxqs	1115	5	gene	gene	NN
cord-296347-fanlvxqs	1115	6	,	,	,
cord-296347-fanlvxqs	1115	7	imp-2	imp-2	NNP
cord-296347-fanlvxqs	1115	8	,	,	,
cord-296347-fanlvxqs	1115	9	is	be	VBZ
cord-296347-fanlvxqs	1115	10	essential	essential	JJ
cord-296347-fanlvxqs	1115	11	for	for	IN
cord-296347-fanlvxqs	1115	12	development	development	NN
cord-296347-fanlvxqs	1115	13	and	and	CC
cord-296347-fanlvxqs	1115	14	is	be	VBZ
cord-296347-fanlvxqs	1115	15	functionally	functionally	RB
cord-296347-fanlvxqs	1115	16	distinct	distinct	JJ
cord-296347-fanlvxqs	1115	17	from	from	IN
cord-296347-fanlvxqs	1115	18	related	related	JJ
cord-296347-fanlvxqs	1115	19	presenilins	presenilins	NNP
cord-296347-fanlvxqs	1115	20	Structure	Structure	NNP
cord-296347-fanlvxqs	1115	21	of	of	IN
cord-296347-fanlvxqs	1115	22	20S	20S	NNP
cord-296347-fanlvxqs	1115	23	proteasome	proteasome	VBN
cord-296347-fanlvxqs	1115	24	from	from	IN
cord-296347-fanlvxqs	1115	25	yeast	yeast	NN
cord-296347-fanlvxqs	1115	26	at	at	IN
cord-296347-fanlvxqs	1115	27	2.4	2.4	CD
cord-296347-fanlvxqs	1115	28	A	a	DT
cord-296347-fanlvxqs	1115	29	resolution	resolution	NN
cord-296347-fanlvxqs	1115	30	A	a	DT
cord-296347-fanlvxqs	1115	31	gated	gated	JJ
cord-296347-fanlvxqs	1115	32	channel	channel	NN
cord-296347-fanlvxqs	1115	33	into	into	IN
cord-296347-fanlvxqs	1115	34	the	the	DT
cord-296347-fanlvxqs	1115	35	proteasome	proteasome	VBN
cord-296347-fanlvxqs	1115	36	core	core	NN
cord-296347-fanlvxqs	1115	37	particle	particle	NN
cord-296347-fanlvxqs	1116	1	The	the	DT
cord-296347-fanlvxqs	1116	2	many	many	JJ
cord-296347-fanlvxqs	1116	3	roads	road	NNS
cord-296347-fanlvxqs	1116	4	to	to	TO
cord-296347-fanlvxqs	1116	5	cross	cross	VB
cord-296347-fanlvxqs	1116	6	-	-	JJ
cord-296347-fanlvxqs	1116	7	presentation	presentation	JJ
cord-296347-fanlvxqs	1116	8	Human	human	JJ
cord-296347-fanlvxqs	1116	9	cytomegalovirus	cytomegalovirus	NN
cord-296347-fanlvxqs	1116	10	immediate	immediate	JJ
cord-296347-fanlvxqs	1116	11	early	early	JJ
cord-296347-fanlvxqs	1116	12	glycoprotein	glycoprotein	NN
cord-296347-fanlvxqs	1116	13	US3	US3	NNP
cord-296347-fanlvxqs	1116	14	retains	retain	VBZ
cord-296347-fanlvxqs	1116	15	MHC	MHC	NNP
cord-296347-fanlvxqs	1116	16	class	class	NN
cord-296347-fanlvxqs	1117	1	I	-PRON-	PRP
cord-296347-fanlvxqs	1117	2	molecules	molecule	NNS
cord-296347-fanlvxqs	1117	3	by	by	IN
cord-296347-fanlvxqs	1117	4	transient	transient	JJ
cord-296347-fanlvxqs	1117	5	association	association	NN
cord-296347-fanlvxqs	1117	6	Myxoma	Myxoma	NNP
cord-296347-fanlvxqs	1117	7	virus	virus	NN
cord-296347-fanlvxqs	1118	1	leukemia	leukemia	NN
cord-296347-fanlvxqs	1118	2	-	-	HYPH
cord-296347-fanlvxqs	1118	3	associated	associate	VBN
cord-296347-fanlvxqs	1118	4	protein	protein	NN
cord-296347-fanlvxqs	1118	5	is	be	VBZ
cord-296347-fanlvxqs	1118	6	responsible	responsible	JJ
cord-296347-fanlvxqs	1118	7	for	for	IN
cord-296347-fanlvxqs	1118	8	major	major	JJ
cord-296347-fanlvxqs	1118	9	histocompatibility	histocompatibility	NN
cord-296347-fanlvxqs	1118	10	complex	complex	JJ
cord-296347-fanlvxqs	1118	11	class	class	NN
cord-296347-fanlvxqs	1119	1	I	-PRON-	PRP
cord-296347-fanlvxqs	1119	2	and	and	CC
cord-296347-fanlvxqs	1119	3	Fas	Fas	NNP
cord-296347-fanlvxqs	1119	4	-	-	HYPH
cord-296347-fanlvxqs	1119	5	CD95	CD95	NNP
cord-296347-fanlvxqs	1119	6	down	down	IN
cord-296347-fanlvxqs	1119	7	-	-	HYPH
cord-296347-fanlvxqs	1119	8	regulation	regulation	NN
cord-296347-fanlvxqs	1119	9	and	and	CC
cord-296347-fanlvxqs	1119	10	defines	define	VBZ
cord-296347-fanlvxqs	1119	11	scrapins	scrapin	NNS
cord-296347-fanlvxqs	1120	1	,	,	,
cord-296347-fanlvxqs	1120	2	a	a	DT
cord-296347-fanlvxqs	1120	3	new	new	JJ
cord-296347-fanlvxqs	1120	4	group	group	NN
cord-296347-fanlvxqs	1120	5	of	of	IN
cord-296347-fanlvxqs	1120	6	surface	surface	NN
cord-296347-fanlvxqs	1120	7	cellular	cellular	JJ
cord-296347-fanlvxqs	1120	8	receptor	receptor	NN
cord-296347-fanlvxqs	1120	9	abductor	abductor	NN
cord-296347-fanlvxqs	1120	10	proteins	protein	VBZ
cord-296347-fanlvxqs	1120	11	Pathways	pathway	NNS
cord-296347-fanlvxqs	1120	12	for	for	IN
cord-296347-fanlvxqs	1120	13	antigen	antigen	NNP
cord-296347-fanlvxqs	1120	14	cross	cross	JJ
cord-296347-fanlvxqs	1120	15	presentation	presentation	NN
cord-296347-fanlvxqs	1120	16	Type	Type	NNP
cord-296347-fanlvxqs	1120	17	III	III	NNP
cord-296347-fanlvxqs	1120	18	effector	effector	NN
cord-296347-fanlvxqs	1120	19	proteins	protein	NNS
cord-296347-fanlvxqs	1120	20	from	from	IN
cord-296347-fanlvxqs	1120	21	the	the	DT
cord-296347-fanlvxqs	1120	22	plant	plant	NN
cord-296347-fanlvxqs	1120	23	pathogen	pathogen	NN
cord-296347-fanlvxqs	1120	24	Xanthomonas	Xanthomonas	NNPS
cord-296347-fanlvxqs	1120	25	and	and	CC
cord-296347-fanlvxqs	1120	26	their	-PRON-	PRP$
cord-296347-fanlvxqs	1120	27	role	role	NN
cord-296347-fanlvxqs	1120	28	in	in	IN
cord-296347-fanlvxqs	1120	29	the	the	DT
cord-296347-fanlvxqs	1120	30	interaction	interaction	NN
cord-296347-fanlvxqs	1120	31	with	with	IN
cord-296347-fanlvxqs	1120	32	the	the	DT
cord-296347-fanlvxqs	1120	33	host	host	NN
cord-296347-fanlvxqs	1120	34	plant	plant	NN
cord-296347-fanlvxqs	1120	35	Ubiquitylation	Ubiquitylation	NNP
cord-296347-fanlvxqs	1120	36	and	and	CC
cord-296347-fanlvxqs	1120	37	cell	cell	NN
cord-296347-fanlvxqs	1120	38	signaling	signal	VBG
cord-296347-fanlvxqs	1120	39	Endoplasmic	Endoplasmic	NNP
cord-296347-fanlvxqs	1120	40	reticulum	reticulum	NN
cord-296347-fanlvxqs	1120	41	retention	retention	NN
cord-296347-fanlvxqs	1120	42	is	be	VBZ
cord-296347-fanlvxqs	1120	43	a	a	DT
cord-296347-fanlvxqs	1120	44	common	common	JJ
cord-296347-fanlvxqs	1120	45	defect	defect	NN
cord-296347-fanlvxqs	1120	46	associated	associate	VBN
cord-296347-fanlvxqs	1120	47	with	with	IN
cord-296347-fanlvxqs	1120	48	tyrosinase	tyrosinase	NN
cord-296347-fanlvxqs	1120	49	-	-	HYPH
cord-296347-fanlvxqs	1120	50	negative	negative	JJ
cord-296347-fanlvxqs	1120	51	albinism	albinism	NN
cord-296347-fanlvxqs	1120	52	Physical	physical	JJ
cord-296347-fanlvxqs	1120	53	and	and	CC
cord-296347-fanlvxqs	1120	54	functional	functional	JJ
cord-296347-fanlvxqs	1120	55	interactions	interaction	NNS
cord-296347-fanlvxqs	1120	56	of	of	IN
cord-296347-fanlvxqs	1120	57	the	the	DT
cord-296347-fanlvxqs	1120	58	cytomegalovirus	cytomegalovirus	NNP
cord-296347-fanlvxqs	1120	59	US6	US6	NNP
cord-296347-fanlvxqs	1120	60	glycoprotein	glycoprotein	NN
cord-296347-fanlvxqs	1120	61	with	with	IN
cord-296347-fanlvxqs	1120	62	the	the	DT
cord-296347-fanlvxqs	1120	63	transporter	transporter	NN
cord-296347-fanlvxqs	1120	64	associated	associate	VBN
cord-296347-fanlvxqs	1120	65	with	with	IN
cord-296347-fanlvxqs	1120	66	antigen	antigen	NN
cord-296347-fanlvxqs	1120	67	processing	processing	NN
cord-296347-fanlvxqs	1120	68	Role	role	NN
cord-296347-fanlvxqs	1120	69	of	of	IN
cord-296347-fanlvxqs	1120	70	N	n	NN
cord-296347-fanlvxqs	1120	71	-	-	HYPH
cord-296347-fanlvxqs	1120	72	linked	link	VBN
cord-296347-fanlvxqs	1120	73	oligosaccharide	oligosaccharide	NN
cord-296347-fanlvxqs	1120	74	recognition	recognition	NN
cord-296347-fanlvxqs	1120	75	,	,	,
cord-296347-fanlvxqs	1120	76	glucose	glucose	NN
cord-296347-fanlvxqs	1120	77	trimming	trimming	NN
cord-296347-fanlvxqs	1120	78	,	,	,
cord-296347-fanlvxqs	1120	79	and	and	CC
cord-296347-fanlvxqs	1120	80	calnexin	calnexin	NN
cord-296347-fanlvxqs	1120	81	in	in	IN
cord-296347-fanlvxqs	1120	82	glycoprotein	glycoprotein	NN
cord-296347-fanlvxqs	1120	83	folding	folding	NN
cord-296347-fanlvxqs	1120	84	and	and	CC
cord-296347-fanlvxqs	1120	85	quality	quality	NN
cord-296347-fanlvxqs	1120	86	control	control	NN
cord-296347-fanlvxqs	1120	87	ER	er	NN
cord-296347-fanlvxqs	1120	88	-	-	HYPH
cord-296347-fanlvxqs	1120	89	associated	associate	VBN
cord-296347-fanlvxqs	1120	90	degradation	degradation	NN
cord-296347-fanlvxqs	1120	91	in	in	IN
cord-296347-fanlvxqs	1120	92	protein	protein	NN
cord-296347-fanlvxqs	1120	93	quality	quality	NN
cord-296347-fanlvxqs	1120	94	control	control	NN
cord-296347-fanlvxqs	1120	95	and	and	CC
cord-296347-fanlvxqs	1120	96	cellular	cellular	JJ
cord-296347-fanlvxqs	1120	97	regulation	regulation	NN
cord-296347-fanlvxqs	1120	98	Ubiquitin	Ubiquitin	NNP
cord-296347-fanlvxqs	1120	99	-	-	HYPH
cord-296347-fanlvxqs	1120	100	mediated	mediate	VBN
cord-296347-fanlvxqs	1120	101	regulation	regulation	NN
cord-296347-fanlvxqs	1120	102	of	of	IN
cord-296347-fanlvxqs	1120	103	3-hydroxy-3-methylglutaryl	3-hydroxy-3-methylglutaryl	CD
cord-296347-fanlvxqs	1120	104	-	-	HYPH
cord-296347-fanlvxqs	1120	105	CoA	coa	NN
cord-296347-fanlvxqs	1120	106	reductase	reductase	NN
cord-296347-fanlvxqs	1120	107	Role	role	NN
cord-296347-fanlvxqs	1120	108	of	of	IN
cord-296347-fanlvxqs	1120	109	26S	26S	NNP
cord-296347-fanlvxqs	1120	110	proteasome	proteasome	NN
cord-296347-fanlvxqs	1120	111	and	and	CC
cord-296347-fanlvxqs	1120	112	HRD	HRD	NNP
cord-296347-fanlvxqs	1120	113	genes	gene	NNS
cord-296347-fanlvxqs	1120	114	in	in	IN
cord-296347-fanlvxqs	1120	115	the	the	DT
cord-296347-fanlvxqs	1120	116	degradation	degradation	NN
cord-296347-fanlvxqs	1120	117	of	of	IN
cord-296347-fanlvxqs	1120	118	3-hydroxy-3-methylglutaryl	3-hydroxy-3-methylglutaryl	CD
cord-296347-fanlvxqs	1120	119	-	-	HYPH
cord-296347-fanlvxqs	1120	120	CoA	coa	NN
cord-296347-fanlvxqs	1120	121	reductase	reductase	NN
cord-296347-fanlvxqs	1120	122	,	,	,
cord-296347-fanlvxqs	1120	123	an	an	DT
cord-296347-fanlvxqs	1120	124	integral	integral	JJ
cord-296347-fanlvxqs	1120	125	endoplasmic	endoplasmic	NN
cord-296347-fanlvxqs	1120	126	reticulum	reticulum	NN
cord-296347-fanlvxqs	1120	127	membrane	membrane	NN
cord-296347-fanlvxqs	1120	128	protein	protein	NN
cord-296347-fanlvxqs	1120	129	A	a	DT
cord-296347-fanlvxqs	1120	130	secreted	secrete	VBN
cord-296347-fanlvxqs	1120	131	Salmonella	Salmonella	NNP
cord-296347-fanlvxqs	1120	132	protein	protein	NN
cord-296347-fanlvxqs	1120	133	with	with	IN
cord-296347-fanlvxqs	1120	134	homology	homology	NN
cord-296347-fanlvxqs	1120	135	to	to	IN
cord-296347-fanlvxqs	1120	136	an	an	DT
cord-296347-fanlvxqs	1120	137	avirulence	avirulence	NN
cord-296347-fanlvxqs	1120	138	determinant	determinant	NN
cord-296347-fanlvxqs	1120	139	of	of	IN
cord-296347-fanlvxqs	1120	140	plant	plant	NN
cord-296347-fanlvxqs	1120	141	pathogenic	pathogenic	JJ
cord-296347-fanlvxqs	1120	142	bacteria	bacteria	NNS
cord-296347-fanlvxqs	1120	143	Retroviral	retroviral	JJ
cord-296347-fanlvxqs	1120	144	restriction	restriction	NN
cord-296347-fanlvxqs	1120	145	by	by	IN
cord-296347-fanlvxqs	1120	146	APOBEC	APOBEC	NNP
cord-296347-fanlvxqs	1120	147	proteins	protein	NNS
cord-296347-fanlvxqs	1121	1	Integral	integral	JJ
cord-296347-fanlvxqs	1121	2	UBL	UBL	NNP
cord-296347-fanlvxqs	1121	3	domain	domain	NN
cord-296347-fanlvxqs	1121	4	proteins	protein	NNS
cord-296347-fanlvxqs	1121	5	:	:	:
cord-296347-fanlvxqs	1122	1	A	a	DT
cord-296347-fanlvxqs	1122	2	family	family	NN
cord-296347-fanlvxqs	1122	3	of	of	IN
cord-296347-fanlvxqs	1122	4	proteasome	proteasome	NN
cord-296347-fanlvxqs	1122	5	interacting	interact	VBG
cord-296347-fanlvxqs	1122	6	proteins	protein	NNS
cord-296347-fanlvxqs	1122	7	Protein	Protein	NNP
cord-296347-fanlvxqs	1122	8	degradation	degradation	NN
cord-296347-fanlvxqs	1122	9	:	:	:
cord-296347-fanlvxqs	1122	10	Recognition	recognition	NN
cord-296347-fanlvxqs	1122	11	of	of	IN
cord-296347-fanlvxqs	1122	12	ubiquitinylated	ubiquitinylated	JJ
cord-296347-fanlvxqs	1122	13	substrates	substrate	NNS
cord-296347-fanlvxqs	1122	14	Transferring	transfer	VBG
cord-296347-fanlvxqs	1122	15	substrates	substrate	NNS
cord-296347-fanlvxqs	1122	16	to	to	IN
cord-296347-fanlvxqs	1122	17	the	the	DT
cord-296347-fanlvxqs	1122	18	26S	26S	NNP
cord-296347-fanlvxqs	1122	19	proteasome	proteasome	JJ
cord-296347-fanlvxqs	1122	20	Rhabdoviruses	Rhabdoviruses	NNP
cord-296347-fanlvxqs	1122	21	and	and	CC
cord-296347-fanlvxqs	1122	22	the	the	DT
cord-296347-fanlvxqs	1122	23	cellular	cellular	JJ
cord-296347-fanlvxqs	1122	24	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1122	25	-	-	HYPH
cord-296347-fanlvxqs	1122	26	proteasome	proteasome	VBN
cord-296347-fanlvxqs	1122	27	system	system	NN
cord-296347-fanlvxqs	1123	1	:	:	:
cord-296347-fanlvxqs	1123	2	A	a	DT
cord-296347-fanlvxqs	1123	3	budding	bud	VBG
cord-296347-fanlvxqs	1123	4	interaction	interaction	NN
cord-296347-fanlvxqs	1123	5	TEB4	TEB4	NNP
cord-296347-fanlvxqs	1123	6	is	be	VBZ
cord-296347-fanlvxqs	1123	7	a	a	DT
cord-296347-fanlvxqs	1123	8	C4HC3	C4HC3	NNP
cord-296347-fanlvxqs	1123	9	RING	ring	NN
cord-296347-fanlvxqs	1123	10	finger	finger	NN
cord-296347-fanlvxqs	1123	11	-	-	HYPH
cord-296347-fanlvxqs	1123	12	containing	contain	VBG
cord-296347-fanlvxqs	1123	13	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1123	14	ligase	ligase	NN
cord-296347-fanlvxqs	1123	15	of	of	IN
cord-296347-fanlvxqs	1123	16	the	the	DT
cord-296347-fanlvxqs	1123	17	endoplasmic	endoplasmic	NN
cord-296347-fanlvxqs	1123	18	reticulum	reticulum	NN
cord-296347-fanlvxqs	1123	19	U	U	NNP
cord-296347-fanlvxqs	1123	20	box	box	NN
cord-296347-fanlvxqs	1123	21	proteins	protein	NNS
cord-296347-fanlvxqs	1123	22	as	as	IN
cord-296347-fanlvxqs	1123	23	a	a	DT
cord-296347-fanlvxqs	1123	24	new	new	JJ
cord-296347-fanlvxqs	1123	25	family	family	NN
cord-296347-fanlvxqs	1123	26	of	of	IN
cord-296347-fanlvxqs	1123	27	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1123	28	-	-	HYPH
cord-296347-fanlvxqs	1123	29	protein	protein	NN
cord-296347-fanlvxqs	1123	30	ligases	ligase	NNS
cord-296347-fanlvxqs	1123	31	Generation	generation	NN
cord-296347-fanlvxqs	1123	32	,	,	,
cord-296347-fanlvxqs	1123	33	translocation	translocation	NN
cord-296347-fanlvxqs	1123	34	,	,	,
cord-296347-fanlvxqs	1123	35	and	and	CC
cord-296347-fanlvxqs	1123	36	presentation	presentation	NN
cord-296347-fanlvxqs	1123	37	of	of	IN
cord-296347-fanlvxqs	1123	38	MHC	MHC	NNP
cord-296347-fanlvxqs	1123	39	class	class	NN
cord-296347-fanlvxqs	1123	40	Irestricted	Irestricted	NNP
cord-296347-fanlvxqs	1123	41	peptides	peptide	NNS
cord-296347-fanlvxqs	1123	42	Human	Human	NNP
cord-296347-fanlvxqs	1123	43	cytomegalovirus	cytomegalovirus	JJ
cord-296347-fanlvxqs	1123	44	US2	US2	NNP
cord-296347-fanlvxqs	1123	45	causes	cause	VBZ
cord-296347-fanlvxqs	1123	46	similar	similar	JJ
cord-296347-fanlvxqs	1123	47	effects	effect	NNS
cord-296347-fanlvxqs	1123	48	on	on	IN
cord-296347-fanlvxqs	1123	49	both	both	DT
cord-296347-fanlvxqs	1123	50	major	major	JJ
cord-296347-fanlvxqs	1123	51	histocompatibility	histocompatibility	NN
cord-296347-fanlvxqs	1123	52	complex	complex	JJ
cord-296347-fanlvxqs	1123	53	class	class	NN
cord-296347-fanlvxqs	1123	54	I	i	NN
cord-296347-fanlvxqs	1123	55	and	and	CC
cord-296347-fanlvxqs	1123	56	II	II	NNP
cord-296347-fanlvxqs	1123	57	proteins	protein	NNS
cord-296347-fanlvxqs	1123	58	in	in	IN
cord-296347-fanlvxqs	1123	59	epithelial	epithelial	JJ
cord-296347-fanlvxqs	1123	60	and	and	CC
cord-296347-fanlvxqs	1123	61	glial	glial	JJ
cord-296347-fanlvxqs	1123	62	cells	cell	NNS
cord-296347-fanlvxqs	1123	63	Inhibition	inhibition	NN
cord-296347-fanlvxqs	1123	64	of	of	IN
cord-296347-fanlvxqs	1123	65	HLA	HLA	NNP
cord-296347-fanlvxqs	1123	66	-	-	HYPH
cord-296347-fanlvxqs	1123	67	DR	DR	NNP
cord-296347-fanlvxqs	1123	68	assembly	assembly	NN
cord-296347-fanlvxqs	1123	69	,	,	,
cord-296347-fanlvxqs	1123	70	transport	transport	NN
cord-296347-fanlvxqs	1123	71	,	,	,
cord-296347-fanlvxqs	1123	72	and	and	CC
cord-296347-fanlvxqs	1123	73	loading	loading	NN
cord-296347-fanlvxqs	1123	74	by	by	IN
cord-296347-fanlvxqs	1123	75	human	human	JJ
cord-296347-fanlvxqs	1123	76	cytomegalovirus	cytomegalovirus	NN
cord-296347-fanlvxqs	1123	77	glycoprotein	glycoprotein	NN
cord-296347-fanlvxqs	1123	78	US3	US3	NNP
cord-296347-fanlvxqs	1123	79	:	:	:
cord-296347-fanlvxqs	1124	1	A	a	DT
cord-296347-fanlvxqs	1124	2	novel	novel	JJ
cord-296347-fanlvxqs	1124	3	mechanism	mechanism	NN
cord-296347-fanlvxqs	1124	4	for	for	IN
cord-296347-fanlvxqs	1124	5	evading	evade	VBG
cord-296347-fanlvxqs	1124	6	major	major	JJ
cord-296347-fanlvxqs	1124	7	histocompatibility	histocompatibility	NN
cord-296347-fanlvxqs	1124	8	complex	complex	JJ
cord-296347-fanlvxqs	1124	9	class	class	NN
cord-296347-fanlvxqs	1124	10	II	II	NNP
cord-296347-fanlvxqs	1124	11	antigen	antigen	NN
cord-296347-fanlvxqs	1124	12	presentation	presentation	NN
cord-296347-fanlvxqs	1125	1	The	the	DT
cord-296347-fanlvxqs	1125	2	ultimate	ultimate	JJ
cord-296347-fanlvxqs	1125	3	nanoscale	nanoscale	JJ
cord-296347-fanlvxqs	1125	4	mincer	mincer	NN
cord-296347-fanlvxqs	1125	5	:	:	:
cord-296347-fanlvxqs	1125	6	Assembly	assembly	NN
cord-296347-fanlvxqs	1125	7	,	,	,
cord-296347-fanlvxqs	1125	8	structure	structure	NN
cord-296347-fanlvxqs	1125	9	and	and	CC
cord-296347-fanlvxqs	1125	10	active	active	JJ
cord-296347-fanlvxqs	1125	11	sites	site	NNS
cord-296347-fanlvxqs	1125	12	of	of	IN
cord-296347-fanlvxqs	1125	13	the	the	DT
cord-296347-fanlvxqs	1125	14	20S	20S	NNP
cord-296347-fanlvxqs	1125	15	proteasome	proteasome	VBN
cord-296347-fanlvxqs	1125	16	core	core	NN
cord-296347-fanlvxqs	1125	17	Roles	Roles	NNP
cord-296347-fanlvxqs	1125	18	of	of	IN
cord-296347-fanlvxqs	1125	19	N	n	NN
cord-296347-fanlvxqs	1125	20	-	-	HYPH
cord-296347-fanlvxqs	1125	21	linked	link	VBN
cord-296347-fanlvxqs	1125	22	glycans	glycan	NNS
cord-296347-fanlvxqs	1125	23	in	in	IN
cord-296347-fanlvxqs	1125	24	the	the	DT
cord-296347-fanlvxqs	1125	25	endoplasmic	endoplasmic	NN
cord-296347-fanlvxqs	1125	26	reticulum	reticulum	NN
cord-296347-fanlvxqs	1125	27	Proteasomes	Proteasomes	NNP
cord-296347-fanlvxqs	1125	28	:	:	:
cord-296347-fanlvxqs	1125	29	A	a	DT
cord-296347-fanlvxqs	1125	30	complex	complex	JJ
cord-296347-fanlvxqs	1125	31	story	story	NN
cord-296347-fanlvxqs	1125	32	Interference	interference	NN
cord-296347-fanlvxqs	1125	33	with	with	IN
cord-296347-fanlvxqs	1125	34	antigen	antigen	NN
cord-296347-fanlvxqs	1125	35	processing	processing	NN
cord-296347-fanlvxqs	1125	36	by	by	IN
cord-296347-fanlvxqs	1125	37	viruses	virus	NNS
cord-296347-fanlvxqs	1126	1	A	a	DT
cord-296347-fanlvxqs	1126	2	viral	viral	JJ
cord-296347-fanlvxqs	1126	3	ER	er	NN
cord-296347-fanlvxqs	1126	4	-	-	HYPH
cord-296347-fanlvxqs	1126	5	resident	resident	JJ
cord-296347-fanlvxqs	1126	6	glycoprotein	glycoprotein	NN
cord-296347-fanlvxqs	1126	7	inactivates	inactivate	VBZ
cord-296347-fanlvxqs	1126	8	the	the	DT
cord-296347-fanlvxqs	1126	9	MHC	MHC	NNP
cord-296347-fanlvxqs	1126	10	-	-	HYPH
cord-296347-fanlvxqs	1126	11	encoded	encode	VBN
cord-296347-fanlvxqs	1126	12	peptide	peptide	NN
cord-296347-fanlvxqs	1126	13	transporter	transporter	NN
cord-296347-fanlvxqs	1126	14	Immune	immune	JJ
cord-296347-fanlvxqs	1126	15	evasion	evasion	NN
cord-296347-fanlvxqs	1126	16	by	by	IN
cord-296347-fanlvxqs	1126	17	cytomegalovirussurvival	cytomegalovirussurvival	JJ
cord-296347-fanlvxqs	1126	18	strategies	strategy	NNS
cord-296347-fanlvxqs	1126	19	of	of	IN
cord-296347-fanlvxqs	1126	20	a	a	DT
cord-296347-fanlvxqs	1126	21	highly	highly	RB
cord-296347-fanlvxqs	1126	22	adapted	adapt	VBN
cord-296347-fanlvxqs	1126	23	opportunist	opportunist	NN
cord-296347-fanlvxqs	1126	24	Cytomegaloviral	Cytomegaloviral	NNP
cord-296347-fanlvxqs	1126	25	control	control	NN
cord-296347-fanlvxqs	1126	26	of	of	IN
cord-296347-fanlvxqs	1126	27	MHC	MHC	NNP
cord-296347-fanlvxqs	1126	28	class	class	NN
cord-296347-fanlvxqs	1127	1	I	-PRON-	PRP
cord-296347-fanlvxqs	1127	2	function	function	VBP
cord-296347-fanlvxqs	1127	3	in	in	IN
cord-296347-fanlvxqs	1127	4	the	the	DT
cord-296347-fanlvxqs	1127	5	mouse	mouse	NN
cord-296347-fanlvxqs	1128	1	Viruses	virus	NNS
cord-296347-fanlvxqs	1128	2	know	know	VBP
cord-296347-fanlvxqs	1128	3	it	-PRON-	PRP
cord-296347-fanlvxqs	1128	4	all	all	DT
cord-296347-fanlvxqs	1128	5	:	:	:
cord-296347-fanlvxqs	1129	1	New	new	JJ
cord-296347-fanlvxqs	1129	2	insights	insight	NNS
cord-296347-fanlvxqs	1129	3	into	into	IN
cord-296347-fanlvxqs	1129	4	IFN	IFN	NNP
cord-296347-fanlvxqs	1129	5	networks	network	NNS
cord-296347-fanlvxqs	1130	1	The	the	DT
cord-296347-fanlvxqs	1130	2	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1130	3	system	system	NN
cord-296347-fanlvxqs	1130	4	for	for	IN
cord-296347-fanlvxqs	1130	5	protein	protein	NN
cord-296347-fanlvxqs	1130	6	degradation	degradation	NN
cord-296347-fanlvxqs	1131	1	The	the	DT
cord-296347-fanlvxqs	1131	2	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1131	3	system	system	NN
cord-296347-fanlvxqs	1132	1	The	the	DT
cord-296347-fanlvxqs	1132	2	human	human	JJ
cord-296347-fanlvxqs	1132	3	cytomegalovirus	cytomegalovirus	NN
cord-296347-fanlvxqs	1132	4	gene	gene	NN
cord-296347-fanlvxqs	1132	5	product	product	NN
cord-296347-fanlvxqs	1132	6	US6	US6	NNP
cord-296347-fanlvxqs	1132	7	inhibits	inhibit	VBZ
cord-296347-fanlvxqs	1132	8	ATP	ATP	NNP
cord-296347-fanlvxqs	1132	9	binding	binding	NN
cord-296347-fanlvxqs	1132	10	by	by	IN
cord-296347-fanlvxqs	1132	11	TAP	TAP	NNP
cord-296347-fanlvxqs	1132	12	A	a	DT
cord-296347-fanlvxqs	1132	13	new	new	JJ
cord-296347-fanlvxqs	1132	14	ticket	ticket	NN
cord-296347-fanlvxqs	1132	15	for	for	IN
cord-296347-fanlvxqs	1132	16	entry	entry	NN
cord-296347-fanlvxqs	1132	17	into	into	IN
cord-296347-fanlvxqs	1132	18	budding	bud	VBG
cord-296347-fanlvxqs	1132	19	vesicles	vesicle	NNS
cord-296347-fanlvxqs	1132	20	-	-	:
cord-296347-fanlvxqs	1132	21	ubiquitin	ubiquitin	VBG
cord-296347-fanlvxqs	1132	22	Regulation	regulation	NN
cord-296347-fanlvxqs	1132	23	of	of	IN
cord-296347-fanlvxqs	1132	24	membrane	membrane	NN
cord-296347-fanlvxqs	1132	25	protein	protein	NN
cord-296347-fanlvxqs	1132	26	transport	transport	NN
cord-296347-fanlvxqs	1132	27	by	by	IN
cord-296347-fanlvxqs	1132	28	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1132	29	and	and	CC
cord-296347-fanlvxqs	1132	30	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1132	31	-	-	HYPH
cord-296347-fanlvxqs	1132	32	binding	bind	VBG
cord-296347-fanlvxqs	1132	33	proteins	protein	NNS
cord-296347-fanlvxqs	1132	34	Structure	Structure	NNP
cord-296347-fanlvxqs	1132	35	of	of	IN
cord-296347-fanlvxqs	1132	36	the	the	DT
cord-296347-fanlvxqs	1132	37	ESCRT	ESCRT	NNP
cord-296347-fanlvxqs	1132	38	-	-	HYPH
cord-296347-fanlvxqs	1132	39	II	II	NNP
cord-296347-fanlvxqs	1132	40	endosomal	endosomal	NNP
cord-296347-fanlvxqs	1132	41	trafficking	traffic	VBG
cord-296347-fanlvxqs	1132	42	complex	complex	JJ
cord-296347-fanlvxqs	1132	43	Strategies	strategy	NNS
cord-296347-fanlvxqs	1132	44	and	and	CC
cord-296347-fanlvxqs	1132	45	mechanisms	mechanism	NNS
cord-296347-fanlvxqs	1132	46	for	for	IN
cord-296347-fanlvxqs	1132	47	host	host	NN
cord-296347-fanlvxqs	1132	48	and	and	CC
cord-296347-fanlvxqs	1132	49	pathogen	pathogen	NN
cord-296347-fanlvxqs	1132	50	survival	survival	NN
cord-296347-fanlvxqs	1132	51	in	in	IN
cord-296347-fanlvxqs	1132	52	acute	acute	JJ
cord-296347-fanlvxqs	1132	53	and	and	CC
cord-296347-fanlvxqs	1132	54	persistent	persistent	JJ
cord-296347-fanlvxqs	1132	55	viral	viral	JJ
cord-296347-fanlvxqs	1132	56	infections	infection	NNS
cord-296347-fanlvxqs	1133	1	Intracellular	Intracellular	NNP
cord-296347-fanlvxqs	1133	2	targeting	target	VBG
cord-296347-fanlvxqs	1133	3	of	of	IN
cord-296347-fanlvxqs	1133	4	the	the	DT
cord-296347-fanlvxqs	1133	5	proteasome	proteasome	NN
cord-296347-fanlvxqs	1133	6	A	a	DT
cord-296347-fanlvxqs	1133	7	role	role	NN
cord-296347-fanlvxqs	1133	8	for	for	IN
cord-296347-fanlvxqs	1133	9	N	n	NN
cord-296347-fanlvxqs	1133	10	-	-	HYPH
cord-296347-fanlvxqs	1133	11	glycanase	glycanase	NN
cord-296347-fanlvxqs	1133	12	in	in	IN
cord-296347-fanlvxqs	1133	13	the	the	DT
cord-296347-fanlvxqs	1133	14	cytosolic	cytosolic	JJ
cord-296347-fanlvxqs	1133	15	turnover	turnover	NN
cord-296347-fanlvxqs	1133	16	of	of	IN
cord-296347-fanlvxqs	1133	17	glycoproteins	glycoprotein	NNS
cord-296347-fanlvxqs	1133	18	Endoplasmic	Endoplasmic	NNP
cord-296347-fanlvxqs	1133	19	reticulum	reticulum	NN
cord-296347-fanlvxqs	1133	20	-	-	HYPH
cord-296347-fanlvxqs	1133	21	associated	associate	VBN
cord-296347-fanlvxqs	1133	22	protein	protein	NN
cord-296347-fanlvxqs	1133	23	degradation	degradation	NN
cord-296347-fanlvxqs	1133	24	-	-	HYPH
cord-296347-fanlvxqs	1133	25	one	one	CD
cord-296347-fanlvxqs	1133	26	model	model	NN
cord-296347-fanlvxqs	1133	27	fits	fit	VBZ
cord-296347-fanlvxqs	1133	28	all	all	DT
cord-296347-fanlvxqs	1133	29	?	?	.
cord-296347-fanlvxqs	1134	1	Hostile	hostile	JJ
cord-296347-fanlvxqs	1134	2	takeovers	takeover	NNS
cord-296347-fanlvxqs	1134	3	:	:	:
cord-296347-fanlvxqs	1135	1	Viral	viral	JJ
cord-296347-fanlvxqs	1135	2	appropriation	appropriation	NN
cord-296347-fanlvxqs	1135	3	of	of	IN
cord-296347-fanlvxqs	1135	4	the	the	DT
cord-296347-fanlvxqs	1135	5	NF	NF	NNP
cord-296347-fanlvxqs	1135	6	-	-	HYPH
cord-296347-fanlvxqs	1135	7	kappaB	kappaB	NNP
cord-296347-fanlvxqs	1135	8	pathway	pathway	NN
cord-296347-fanlvxqs	1135	9	Attenuation	attenuation	NN
cord-296347-fanlvxqs	1135	10	of	of	IN
cord-296347-fanlvxqs	1135	11	HLA	HLA	NNP
cord-296347-fanlvxqs	1135	12	-	-	HYPH
cord-296347-fanlvxqs	1135	13	DR	DR	NNP
cord-296347-fanlvxqs	1135	14	expression	expression	NN
cord-296347-fanlvxqs	1135	15	by	by	IN
cord-296347-fanlvxqs	1135	16	mononuclear	mononuclear	JJ
cord-296347-fanlvxqs	1135	17	phagocytes	phagocyte	NNS
cord-296347-fanlvxqs	1135	18	infected	infect	VBN
cord-296347-fanlvxqs	1135	19	with	with	IN
cord-296347-fanlvxqs	1135	20	Mycobacterium	Mycobacterium	NNP
cord-296347-fanlvxqs	1135	21	tuberculosis	tuberculosis	NN
cord-296347-fanlvxqs	1135	22	is	be	VBZ
cord-296347-fanlvxqs	1135	23	related	relate	VBN
cord-296347-fanlvxqs	1135	24	to	to	IN
cord-296347-fanlvxqs	1135	25	intracellular	intracellular	JJ
cord-296347-fanlvxqs	1135	26	sequestration	sequestration	NN
cord-296347-fanlvxqs	1135	27	of	of	IN
cord-296347-fanlvxqs	1135	28	immature	immature	JJ
cord-296347-fanlvxqs	1135	29	class	class	NN
cord-296347-fanlvxqs	1135	30	II	ii	NN
cord-296347-fanlvxqs	1135	31	heterodimers	heterodimer	NNS
cord-296347-fanlvxqs	1135	32	SP	sp	NN
cord-296347-fanlvxqs	1135	33	-	-	HYPH
cord-296347-fanlvxqs	1135	34	RING	ring	NN
cord-296347-fanlvxqs	1135	35	for	for	IN
cord-296347-fanlvxqs	1135	36	SUMO	SUMO	NNP
cord-296347-fanlvxqs	1135	37	:	:	:
cord-296347-fanlvxqs	1135	38	New	new	JJ
cord-296347-fanlvxqs	1135	39	functions	function	NNS
cord-296347-fanlvxqs	1135	40	bloom	bloom	VBP
cord-296347-fanlvxqs	1135	41	for	for	IN
cord-296347-fanlvxqs	1135	42	a	a	DT
cord-296347-fanlvxqs	1135	43	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1135	44	-	-	HYPH
cord-296347-fanlvxqs	1135	45	like	like	JJ
cord-296347-fanlvxqs	1135	46	protein	protein	NN
cord-296347-fanlvxqs	1136	1	The	the	DT
cord-296347-fanlvxqs	1136	2	role	role	NN
cord-296347-fanlvxqs	1136	3	of	of	IN
cord-296347-fanlvxqs	1136	4	IL-6	IL-6	NNP
cord-296347-fanlvxqs	1136	5	and	and	CC
cord-296347-fanlvxqs	1136	6	STAT3	STAT3	NNP
cord-296347-fanlvxqs	1136	7	in	in	IN
cord-296347-fanlvxqs	1136	8	inflammation	inflammation	NN
cord-296347-fanlvxqs	1136	9	and	and	CC
cord-296347-fanlvxqs	1136	10	cancer	cancer	NN
cord-296347-fanlvxqs	1136	11	Lysosomal	Lysosomal	NNP
cord-296347-fanlvxqs	1136	12	cysteine	cysteine	NN
cord-296347-fanlvxqs	1136	13	proteases	protease	NNS
cord-296347-fanlvxqs	1136	14	regulate	regulate	VBP
cord-296347-fanlvxqs	1136	15	antigen	antigen	NN
cord-296347-fanlvxqs	1136	16	presentation	presentation	NN
cord-296347-fanlvxqs	1136	17	Multiubiquitylation	Multiubiquitylation	NNP
cord-296347-fanlvxqs	1136	18	by	by	IN
cord-296347-fanlvxqs	1136	19	E4	E4	NNP
cord-296347-fanlvxqs	1136	20	enzymes	enzyme	NNS
cord-296347-fanlvxqs	1136	21	:	:	:
cord-296347-fanlvxqs	1136	22	'	'	``
cord-296347-fanlvxqs	1136	23	One	one	CD
cord-296347-fanlvxqs	1136	24	size	size	NN
cord-296347-fanlvxqs	1136	25	'	'	''
cord-296347-fanlvxqs	1136	26	does	do	VBZ
cord-296347-fanlvxqs	1136	27	n't	not	RB
cord-296347-fanlvxqs	1136	28	fit	fit	VB
cord-296347-fanlvxqs	1136	29	all	all	DT
cord-296347-fanlvxqs	1136	30	Role	role	NN
cord-296347-fanlvxqs	1136	31	of	of	IN
cord-296347-fanlvxqs	1136	32	Herp	Herp	NNP
cord-296347-fanlvxqs	1136	33	in	in	IN
cord-296347-fanlvxqs	1136	34	the	the	DT
cord-296347-fanlvxqs	1136	35	endoplasmic	endoplasmic	NN
cord-296347-fanlvxqs	1136	36	reticulum	reticulum	NN
cord-296347-fanlvxqs	1136	37	stress	stress	NN
cord-296347-fanlvxqs	1136	38	response	response	NN
cord-296347-fanlvxqs	1137	1	The	the	DT
cord-296347-fanlvxqs	1137	2	lysosomal	lysosomal	JJ
cord-296347-fanlvxqs	1137	3	cysteine	cysteine	NN
cord-296347-fanlvxqs	1137	4	proteases	protease	NNS
cord-296347-fanlvxqs	1137	5	in	in	IN
cord-296347-fanlvxqs	1137	6	MHC	MHC	NNP
cord-296347-fanlvxqs	1137	7	class	class	NN
cord-296347-fanlvxqs	1137	8	II	II	NNP
cord-296347-fanlvxqs	1137	9	antigen	antigen	NN
cord-296347-fanlvxqs	1137	10	presentation	presentation	NN
cord-296347-fanlvxqs	1137	11	Crystal	Crystal	NNP
cord-296347-fanlvxqs	1137	12	structure	structure	NN
cord-296347-fanlvxqs	1137	13	of	of	IN
cord-296347-fanlvxqs	1137	14	a	a	DT
cord-296347-fanlvxqs	1137	15	UBP	UBP	NNP
cord-296347-fanlvxqs	1137	16	-	-	HYPH
cord-296347-fanlvxqs	1137	17	family	family	NN
cord-296347-fanlvxqs	1137	18	deubiquitinating	deubiquitinating	NN
cord-296347-fanlvxqs	1137	19	enzyme	enzyme	NN
cord-296347-fanlvxqs	1137	20	in	in	IN
cord-296347-fanlvxqs	1137	21	isolation	isolation	NN
cord-296347-fanlvxqs	1137	22	and	and	CC
cord-296347-fanlvxqs	1137	23	in	in	IN
cord-296347-fanlvxqs	1137	24	complex	complex	NN
cord-296347-fanlvxqs	1137	25	with	with	IN
cord-296347-fanlvxqs	1137	26	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1137	27	aldehyde	aldehyde	NN
cord-296347-fanlvxqs	1138	1	The	the	DT
cord-296347-fanlvxqs	1138	2	alpha	alpha	NN
cord-296347-fanlvxqs	1138	3	chain	chain	NN
cord-296347-fanlvxqs	1138	4	of	of	IN
cord-296347-fanlvxqs	1138	5	the	the	DT
cord-296347-fanlvxqs	1138	6	T	T	NNP
cord-296347-fanlvxqs	1138	7	cell	cell	NN
cord-296347-fanlvxqs	1138	8	antigen	antigen	NN
cord-296347-fanlvxqs	1138	9	receptor	receptor	NN
cord-296347-fanlvxqs	1138	10	is	be	VBZ
cord-296347-fanlvxqs	1138	11	degraded	degrade	VBN
cord-296347-fanlvxqs	1138	12	in	in	IN
cord-296347-fanlvxqs	1138	13	the	the	DT
cord-296347-fanlvxqs	1138	14	cytosol	cytosol	NN
cord-296347-fanlvxqs	1139	1	The	the	DT
cord-296347-fanlvxqs	1139	2	ESCRT	ESCRT	NNP
cord-296347-fanlvxqs	1139	3	complexes	complex	NNS
cord-296347-fanlvxqs	1139	4	:	:	:
cord-296347-fanlvxqs	1140	1	Structure	structure	NN
cord-296347-fanlvxqs	1140	2	and	and	CC
cord-296347-fanlvxqs	1140	3	mechanism	mechanism	NN
cord-296347-fanlvxqs	1140	4	of	of	IN
cord-296347-fanlvxqs	1140	5	a	a	DT
cord-296347-fanlvxqs	1140	6	membrane	membrane	NN
cord-296347-fanlvxqs	1140	7	-	-	HYPH
cord-296347-fanlvxqs	1140	8	trafficking	traffic	VBG
cord-296347-fanlvxqs	1140	9	network	network	NN
cord-296347-fanlvxqs	1140	10	Mycobacterium	Mycobacterium	NNP
cord-296347-fanlvxqs	1140	11	avium	avium	NN
cord-296347-fanlvxqs	1140	12	infection	infection	NN
cord-296347-fanlvxqs	1140	13	of	of	IN
cord-296347-fanlvxqs	1140	14	mouse	mouse	NN
cord-296347-fanlvxqs	1140	15	macrophages	macrophage	NNS
cord-296347-fanlvxqs	1140	16	inhibits	inhibit	VBZ
cord-296347-fanlvxqs	1141	1	IFN	IFN	NNP
cord-296347-fanlvxqs	1141	2	-	-	HYPH
cord-296347-fanlvxqs	1141	3	gamma	gamma	JJ
cord-296347-fanlvxqs	1141	4	Janus	Janus	NNP
cord-296347-fanlvxqs	1141	5	kinase	kinase	NN
cord-296347-fanlvxqs	1141	6	-	-	HYPH
cord-296347-fanlvxqs	1141	7	STAT	stat	NN
cord-296347-fanlvxqs	1141	8	signaling	signaling	NN
cord-296347-fanlvxqs	1141	9	and	and	CC
cord-296347-fanlvxqs	1141	10	gene	gene	NN
cord-296347-fanlvxqs	1141	11	induction	induction	NN
cord-296347-fanlvxqs	1141	12	by	by	IN
cord-296347-fanlvxqs	1141	13	downregulation	downregulation	NN
cord-296347-fanlvxqs	1141	14	of	of	IN
cord-296347-fanlvxqs	1141	15	the	the	DT
cord-296347-fanlvxqs	1141	16	IFN	IFN	NNP
cord-296347-fanlvxqs	1141	17	-	-	HYPH
cord-296347-fanlvxqs	1141	18	gamma	gamma	NNP
cord-296347-fanlvxqs	1141	19	receptor	receptor	NN
cord-296347-fanlvxqs	1141	20	Parkin	Parkin	NNP
cord-296347-fanlvxqs	1141	21	suppresses	suppress	VBZ
cord-296347-fanlvxqs	1141	22	unfolded	unfold	VBN
cord-296347-fanlvxqs	1141	23	protein	protein	NN
cord-296347-fanlvxqs	1141	24	stressinduced	stressinduced	JJ
cord-296347-fanlvxqs	1141	25	cell	cell	NN
cord-296347-fanlvxqs	1141	26	death	death	NN
cord-296347-fanlvxqs	1141	27	through	through	IN
cord-296347-fanlvxqs	1141	28	its	-PRON-	PRP$
cord-296347-fanlvxqs	1141	29	E3	e3	NN
cord-296347-fanlvxqs	1141	30	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1141	31	-	-	HYPH
cord-296347-fanlvxqs	1141	32	protein	protein	NN
cord-296347-fanlvxqs	1141	33	ligase	ligase	NN
cord-296347-fanlvxqs	1141	34	activity	activity	NN
cord-296347-fanlvxqs	1141	35	CHIP	chip	NN
cord-296347-fanlvxqs	1142	1	is	be	VBZ
cord-296347-fanlvxqs	1142	2	associated	associate	VBN
cord-296347-fanlvxqs	1142	3	with	with	IN
cord-296347-fanlvxqs	1142	4	Parkin	Parkin	NNP
cord-296347-fanlvxqs	1142	5	,	,	,
cord-296347-fanlvxqs	1142	6	a	a	DT
cord-296347-fanlvxqs	1142	7	gene	gene	NN
cord-296347-fanlvxqs	1142	8	responsible	responsible	JJ
cord-296347-fanlvxqs	1142	9	for	for	IN
cord-296347-fanlvxqs	1142	10	familial	familial	JJ
cord-296347-fanlvxqs	1142	11	Parkinson	Parkinson	NNP
cord-296347-fanlvxqs	1142	12	's	's	POS
cord-296347-fanlvxqs	1142	13	disease	disease	NN
cord-296347-fanlvxqs	1142	14	,	,	,
cord-296347-fanlvxqs	1142	15	and	and	CC
cord-296347-fanlvxqs	1142	16	enhances	enhance	VBZ
cord-296347-fanlvxqs	1142	17	its	-PRON-	PRP$
cord-296347-fanlvxqs	1142	18	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1142	19	ligase	ligase	NN
cord-296347-fanlvxqs	1142	20	activity	activity	NN
cord-296347-fanlvxqs	1143	1	The	the	DT
cord-296347-fanlvxqs	1143	2	Nedd4	nedd4	JJ
cord-296347-fanlvxqs	1143	3	family	family	NN
cord-296347-fanlvxqs	1143	4	of	of	IN
cord-296347-fanlvxqs	1143	5	E3	E3	NNP
cord-296347-fanlvxqs	1143	6	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1143	7	ligases	ligase	NNS
cord-296347-fanlvxqs	1143	8	:	:	:
cord-296347-fanlvxqs	1143	9	Functional	functional	JJ
cord-296347-fanlvxqs	1143	10	diversity	diversity	NN
cord-296347-fanlvxqs	1143	11	within	within	IN
cord-296347-fanlvxqs	1143	12	a	a	DT
cord-296347-fanlvxqs	1143	13	common	common	JJ
cord-296347-fanlvxqs	1143	14	modular	modular	JJ
cord-296347-fanlvxqs	1143	15	architecture	architecture	NN
cord-296347-fanlvxqs	1144	1	The	the	DT
cord-296347-fanlvxqs	1144	2	Epstein	Epstein	NNP
cord-296347-fanlvxqs	1144	3	-	-	HYPH
cord-296347-fanlvxqs	1144	4	Barr	Barr	NNP
cord-296347-fanlvxqs	1144	5	virus	virus	NN
cord-296347-fanlvxqs	1144	6	protein	protein	NN
cord-296347-fanlvxqs	1144	7	,	,	,
cord-296347-fanlvxqs	1144	8	latent	latent	JJ
cord-296347-fanlvxqs	1144	9	membrane	membrane	NN
cord-296347-fanlvxqs	1144	10	protein	protein	NN
cord-296347-fanlvxqs	1144	11	2A	2a	CD
cord-296347-fanlvxqs	1144	12	,	,	,
cord-296347-fanlvxqs	1144	13	co	co	NN
cord-296347-fanlvxqs	1144	14	-	-	NN
cord-296347-fanlvxqs	1144	15	opts	opt	VBZ
cord-296347-fanlvxqs	1144	16	tyrosine	tyrosine	NN
cord-296347-fanlvxqs	1144	17	kinases	kinase	NNS
cord-296347-fanlvxqs	1144	18	used	use	VBN
cord-296347-fanlvxqs	1144	19	by	by	IN
cord-296347-fanlvxqs	1144	20	the	the	DT
cord-296347-fanlvxqs	1144	21	T	T	NNP
cord-296347-fanlvxqs	1144	22	cell	cell	NN
cord-296347-fanlvxqs	1144	23	receptor	receptor	NN
cord-296347-fanlvxqs	1144	24	NOD	NOD	NNP
cord-296347-fanlvxqs	1144	25	-	-	HYPH
cord-296347-fanlvxqs	1144	26	LRR	LRR	NNP
cord-296347-fanlvxqs	1144	27	proteins	protein	NNS
cord-296347-fanlvxqs	1144	28	:	:	:
cord-296347-fanlvxqs	1144	29	Role	role	NN
cord-296347-fanlvxqs	1144	30	in	in	IN
cord-296347-fanlvxqs	1144	31	host	host	NN
cord-296347-fanlvxqs	1144	32	-	-	HYPH
cord-296347-fanlvxqs	1144	33	microbial	microbial	JJ
cord-296347-fanlvxqs	1144	34	interactions	interaction	NNS
cord-296347-fanlvxqs	1144	35	and	and	CC
cord-296347-fanlvxqs	1144	36	inflammatory	inflammatory	JJ
cord-296347-fanlvxqs	1144	37	disease	disease	NN
cord-296347-fanlvxqs	1144	38	Downregulation	Downregulation	NNP
cord-296347-fanlvxqs	1144	39	of	of	IN
cord-296347-fanlvxqs	1144	40	major	major	JJ
cord-296347-fanlvxqs	1144	41	histocompatibility	histocompatibility	NN
cord-296347-fanlvxqs	1144	42	complex	complex	JJ
cord-296347-fanlvxqs	1144	43	class	class	NN
cord-296347-fanlvxqs	1145	1	I	-PRON-	PRP
cord-296347-fanlvxqs	1145	2	molecules	molecule	NNS
cord-296347-fanlvxqs	1145	3	by	by	IN
cord-296347-fanlvxqs	1145	4	Kaposi	Kaposi	NNP
cord-296347-fanlvxqs	1145	5	's	's	POS
cord-296347-fanlvxqs	1145	6	sarcoma	sarcoma	NN
cord-296347-fanlvxqs	1145	7	-	-	HYPH
cord-296347-fanlvxqs	1145	8	associated	associate	VBN
cord-296347-fanlvxqs	1145	9	herpesvirus	herpesvirus	NN
cord-296347-fanlvxqs	1145	10	K3	K3	NNP
cord-296347-fanlvxqs	1145	11	and	and	CC
cord-296347-fanlvxqs	1145	12	K5	K5	NNP
cord-296347-fanlvxqs	1145	13	proteins	protein	NNS
cord-296347-fanlvxqs	1145	14	Htm1p	Htm1p	NNP
cord-296347-fanlvxqs	1145	15	,	,	,
cord-296347-fanlvxqs	1145	16	a	a	DT
cord-296347-fanlvxqs	1145	17	mannosidase	mannosidase	NN
cord-296347-fanlvxqs	1145	18	-	-	HYPH
cord-296347-fanlvxqs	1145	19	like	like	JJ
cord-296347-fanlvxqs	1145	20	protein	protein	NN
cord-296347-fanlvxqs	1145	21	,	,	,
cord-296347-fanlvxqs	1145	22	is	be	VBZ
cord-296347-fanlvxqs	1145	23	involved	involve	VBN
cord-296347-fanlvxqs	1145	24	in	in	IN
cord-296347-fanlvxqs	1145	25	glycoprotein	glycoprotein	NN
cord-296347-fanlvxqs	1145	26	degradation	degradation	NN
cord-296347-fanlvxqs	1145	27	in	in	IN
cord-296347-fanlvxqs	1145	28	yeast	yeast	NN
cord-296347-fanlvxqs	1145	29	A	a	DT
cord-296347-fanlvxqs	1145	30	bacterial	bacterial	JJ
cord-296347-fanlvxqs	1145	31	inhibitor	inhibitor	NN
cord-296347-fanlvxqs	1145	32	of	of	IN
cord-296347-fanlvxqs	1145	33	host	host	NN
cord-296347-fanlvxqs	1145	34	programmed	program	VBN
cord-296347-fanlvxqs	1145	35	cell	cell	NN
cord-296347-fanlvxqs	1145	36	death	death	NN
cord-296347-fanlvxqs	1145	37	defenses	defense	NNS
cord-296347-fanlvxqs	1145	38	is	be	VBZ
cord-296347-fanlvxqs	1146	1	an	an	DT
cord-296347-fanlvxqs	1146	2	E3	e3	NN
cord-296347-fanlvxqs	1146	3	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1146	4	ligase	ligase	NN
cord-296347-fanlvxqs	1146	5	HIV-1	HIV-1	NNP
cord-296347-fanlvxqs	1146	6	Nef	Nef	NNP
cord-296347-fanlvxqs	1146	7	stabilizes	stabilize	VBZ
cord-296347-fanlvxqs	1146	8	the	the	DT
cord-296347-fanlvxqs	1146	9	association	association	NNP
cord-296347-fanlvxqs	1146	10	of	of	IN
cord-296347-fanlvxqs	1146	11	adaptor	adaptor	NNP
cord-296347-fanlvxqs	1146	12	protein	protein	NN
cord-296347-fanlvxqs	1146	13	complexes	complex	NNS
cord-296347-fanlvxqs	1146	14	with	with	IN
cord-296347-fanlvxqs	1146	15	membranes	membrane	NNS
cord-296347-fanlvxqs	1146	16	Recognition	Recognition	NNP
cord-296347-fanlvxqs	1146	17	of	of	IN
cord-296347-fanlvxqs	1146	18	dileucine	dileucine	NN
cord-296347-fanlvxqs	1146	19	-	-	HYPH
cord-296347-fanlvxqs	1146	20	based	base	VBN
cord-296347-fanlvxqs	1146	21	sorting	sorting	NN
cord-296347-fanlvxqs	1146	22	signals	signal	NNS
cord-296347-fanlvxqs	1146	23	from	from	IN
cord-296347-fanlvxqs	1146	24	HIV-1	HIV-1	NNP
cord-296347-fanlvxqs	1146	25	Nef	Nef	NNP
cord-296347-fanlvxqs	1146	26	and	and	CC
cord-296347-fanlvxqs	1146	27	LIMP	LIMP	NNP
cord-296347-fanlvxqs	1146	28	-	-	HYPH
cord-296347-fanlvxqs	1146	29	II	II	NNP
cord-296347-fanlvxqs	1146	30	by	by	IN
cord-296347-fanlvxqs	1146	31	the	the	DT
cord-296347-fanlvxqs	1146	32	AP-1	AP-1	NNP
cord-296347-fanlvxqs	1146	33	gamma	gamma	NN
cord-296347-fanlvxqs	1146	34	-	-	HYPH
cord-296347-fanlvxqs	1146	35	sigma1	sigma1	NNP
cord-296347-fanlvxqs	1146	36	and	and	CC
cord-296347-fanlvxqs	1146	37	AP-3	AP-3	NNP
cord-296347-fanlvxqs	1146	38	delta	delta	NNP
cord-296347-fanlvxqs	1146	39	-	-	HYPH
cord-296347-fanlvxqs	1146	40	sigma3	sigma3	NN
cord-296347-fanlvxqs	1146	41	hemicomplexes	hemicomplexes	NNP
cord-296347-fanlvxqs	1146	42	Protein	Protein	NNP
cord-296347-fanlvxqs	1146	43	dislocation	dislocation	NN
cord-296347-fanlvxqs	1146	44	from	from	IN
cord-296347-fanlvxqs	1146	45	the	the	DT
cord-296347-fanlvxqs	1146	46	ER	ER	NNP
cord-296347-fanlvxqs	1146	47	requires	require	VBZ
cord-296347-fanlvxqs	1146	48	polyubiquitination	polyubiquitination	NN
cord-296347-fanlvxqs	1146	49	and	and	CC
cord-296347-fanlvxqs	1146	50	the	the	DT
cord-296347-fanlvxqs	1146	51	AAA	AAA	NNP
cord-296347-fanlvxqs	1146	52	-	-	HYPH
cord-296347-fanlvxqs	1146	53	ATPase	ATPase	NNP
cord-296347-fanlvxqs	1146	54	Cdc48	Cdc48	NNP
cord-296347-fanlvxqs	1146	55	Multiple	multiple	JJ
cord-296347-fanlvxqs	1146	56	proteolytic	proteolytic	JJ
cord-296347-fanlvxqs	1146	57	systems	system	NNS
cord-296347-fanlvxqs	1146	58	,	,	,
cord-296347-fanlvxqs	1146	59	including	include	VBG
cord-296347-fanlvxqs	1146	60	the	the	DT
cord-296347-fanlvxqs	1146	61	proteasome	proteasome	NN
cord-296347-fanlvxqs	1146	62	,	,	,
cord-296347-fanlvxqs	1146	63	contribute	contribute	VB
cord-296347-fanlvxqs	1146	64	to	to	IN
cord-296347-fanlvxqs	1146	65	CFTR	CFTR	NNP
cord-296347-fanlvxqs	1146	66	processing	processing	NN
cord-296347-fanlvxqs	1146	67	RING	ring	NN
cord-296347-fanlvxqs	1146	68	finger	finger	NN
cord-296347-fanlvxqs	1146	69	specificity	specificity	NN
cord-296347-fanlvxqs	1146	70	in	in	IN
cord-296347-fanlvxqs	1146	71	SCF	scf	NN
cord-296347-fanlvxqs	1146	72	-	-	HYPH
cord-296347-fanlvxqs	1146	73	driven	drive	VBN
cord-296347-fanlvxqs	1146	74	protein	protein	NN
cord-296347-fanlvxqs	1146	75	destruction	destruction	NN
cord-296347-fanlvxqs	1146	76	Systematic	systematic	JJ
cord-296347-fanlvxqs	1146	77	analysis	analysis	NN
cord-296347-fanlvxqs	1146	78	and	and	CC
cord-296347-fanlvxqs	1146	79	nomenclature	nomenclature	NN
cord-296347-fanlvxqs	1146	80	of	of	IN
cord-296347-fanlvxqs	1146	81	mammalian	mammalian	JJ
cord-296347-fanlvxqs	1146	82	F	F	NNP
cord-296347-fanlvxqs	1146	83	-	-	HYPH
cord-296347-fanlvxqs	1146	84	box	box	NN
cord-296347-fanlvxqs	1146	85	proteins	protein	NNS
cord-296347-fanlvxqs	1147	1	CD4	CD4	NNP
cord-296347-fanlvxqs	1147	2	phosphorylation	phosphorylation	NN
cord-296347-fanlvxqs	1147	3	partially	partially	RB
cord-296347-fanlvxqs	1147	4	reverses	reverse	VBZ
cord-296347-fanlvxqs	1147	5	Nef	Nef	NNP
cord-296347-fanlvxqs	1147	6	down	down	JJ
cord-296347-fanlvxqs	1147	7	-	-	HYPH
cord-296347-fanlvxqs	1147	8	regulation	regulation	NN
cord-296347-fanlvxqs	1147	9	of	of	IN
cord-296347-fanlvxqs	1147	10	CD4	CD4	NNP
cord-296347-fanlvxqs	1147	11	HIV	HIV	NNP
cord-296347-fanlvxqs	1147	12	Nefmediated	Nefmediated	NNP
cord-296347-fanlvxqs	1147	13	CD4	CD4	NNP
cord-296347-fanlvxqs	1147	14	down	down	IN
cord-296347-fanlvxqs	1147	15	-	-	HYPH
cord-296347-fanlvxqs	1147	16	regulation	regulation	NN
cord-296347-fanlvxqs	1147	17	is	be	VBZ
cord-296347-fanlvxqs	1147	18	adaptor	adaptor	NN
cord-296347-fanlvxqs	1147	19	protein	protein	NN
cord-296347-fanlvxqs	1147	20	complex	complex	JJ
cord-296347-fanlvxqs	1147	21	2	2	CD
cord-296347-fanlvxqs	1147	22	dependent	dependent	JJ
cord-296347-fanlvxqs	1147	23	RING	ring	NN
cord-296347-fanlvxqs	1147	24	finger	finger	NN
cord-296347-fanlvxqs	1147	25	proteins	protein	NNS
cord-296347-fanlvxqs	1147	26	:	:	:
cord-296347-fanlvxqs	1147	27	Mediators	mediator	NNS
cord-296347-fanlvxqs	1147	28	of	of	IN
cord-296347-fanlvxqs	1147	29	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1147	30	ligase	ligase	NN
cord-296347-fanlvxqs	1147	31	activity	activity	NN
cord-296347-fanlvxqs	1148	1	A	a	DT
cord-296347-fanlvxqs	1148	2	proteolytic	proteolytic	JJ
cord-296347-fanlvxqs	1148	3	pathway	pathway	NN
cord-296347-fanlvxqs	1148	4	that	that	WDT
cord-296347-fanlvxqs	1148	5	recognizes	recognize	VBZ
cord-296347-fanlvxqs	1148	6	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1148	7	as	as	IN
cord-296347-fanlvxqs	1148	8	a	a	DT
cord-296347-fanlvxqs	1148	9	degradation	degradation	NN
cord-296347-fanlvxqs	1148	10	signal	signal	NN
cord-296347-fanlvxqs	1148	11	Multiple	multiple	JJ
cord-296347-fanlvxqs	1148	12	independent	independent	JJ
cord-296347-fanlvxqs	1148	13	loci	locus	NNS
cord-296347-fanlvxqs	1148	14	within	within	IN
cord-296347-fanlvxqs	1148	15	the	the	DT
cord-296347-fanlvxqs	1148	16	human	human	JJ
cord-296347-fanlvxqs	1148	17	cytomegalovirus	cytomegalovirus	NN
cord-296347-fanlvxqs	1148	18	unique	unique	JJ
cord-296347-fanlvxqs	1148	19	short	short	JJ
cord-296347-fanlvxqs	1148	20	region	region	NN
cord-296347-fanlvxqs	1149	1	downregulate	downregulate	VB
cord-296347-fanlvxqs	1149	2	expression	expression	NN
cord-296347-fanlvxqs	1149	3	of	of	IN
cord-296347-fanlvxqs	1149	4	major	major	JJ
cord-296347-fanlvxqs	1149	5	histocompatibility	histocompatibility	NN
cord-296347-fanlvxqs	1149	6	complex	complex	JJ
cord-296347-fanlvxqs	1149	7	class	class	NN
cord-296347-fanlvxqs	1150	1	I	-PRON-	PRP
cord-296347-fanlvxqs	1150	2	heavy	heavy	JJ
cord-296347-fanlvxqs	1150	3	chains	chain	NNS
cord-296347-fanlvxqs	1151	1	Human	human	JJ
cord-296347-fanlvxqs	1151	2	cytomegalovirus	cytomegalovirus	NN
cord-296347-fanlvxqs	1151	3	US3	US3	NNP
cord-296347-fanlvxqs	1151	4	impairs	impair	VBZ
cord-296347-fanlvxqs	1151	5	transport	transport	NN
cord-296347-fanlvxqs	1151	6	and	and	CC
cord-296347-fanlvxqs	1151	7	maturation	maturation	NN
cord-296347-fanlvxqs	1151	8	of	of	IN
cord-296347-fanlvxqs	1151	9	major	major	JJ
cord-296347-fanlvxqs	1151	10	histocompatibility	histocompatibility	NN
cord-296347-fanlvxqs	1151	11	complex	complex	JJ
cord-296347-fanlvxqs	1151	12	class	class	NN
cord-296347-fanlvxqs	1152	1	I	-PRON-	PRP
cord-296347-fanlvxqs	1152	2	heavy	heavy	JJ
cord-296347-fanlvxqs	1152	3	chains	chain	NNS
cord-296347-fanlvxqs	1153	1	Nef	Nef	NNP
cord-296347-fanlvxqs	1153	2	:	:	:
cord-296347-fanlvxqs	1153	3	'	'	``
cord-296347-fanlvxqs	1153	4	'	'	''
cord-296347-fanlvxqs	1153	5	Necessary	necessary	JJ
cord-296347-fanlvxqs	1153	6	and	and	CC
cord-296347-fanlvxqs	1153	7	enforcing	enforce	VBG
cord-296347-fanlvxqs	1153	8	factor	factor	NN
cord-296347-fanlvxqs	1153	9	'	'	''
cord-296347-fanlvxqs	1153	10	'	'	''
cord-296347-fanlvxqs	1153	11	in	in	IN
cord-296347-fanlvxqs	1153	12	HIV	HIV	NNP
cord-296347-fanlvxqs	1153	13	infection	infection	NN
cord-296347-fanlvxqs	1153	14	Phagocytosis	Phagocytosis	NNP
cord-296347-fanlvxqs	1153	15	:	:	:
cord-296347-fanlvxqs	1153	16	At	at	IN
cord-296347-fanlvxqs	1153	17	the	the	DT
cord-296347-fanlvxqs	1153	18	crossroads	crossroad	NNS
cord-296347-fanlvxqs	1153	19	of	of	IN
cord-296347-fanlvxqs	1153	20	innate	innate	JJ
cord-296347-fanlvxqs	1153	21	and	and	CC
cord-296347-fanlvxqs	1153	22	adaptive	adaptive	JJ
cord-296347-fanlvxqs	1153	23	immunity	immunity	NN
cord-296347-fanlvxqs	1154	1	The	the	DT
cord-296347-fanlvxqs	1154	2	protein	protein	NN
cord-296347-fanlvxqs	1154	3	translocation	translocation	NN
cord-296347-fanlvxqs	1154	4	channel	channel	NN
cord-296347-fanlvxqs	1154	5	binds	bind	VBZ
cord-296347-fanlvxqs	1154	6	proteasomes	proteasomes	NNP
cord-296347-fanlvxqs	1154	7	to	to	IN
cord-296347-fanlvxqs	1154	8	the	the	DT
cord-296347-fanlvxqs	1154	9	endoplasmic	endoplasmic	NN
cord-296347-fanlvxqs	1154	10	reticulum	reticulum	NN
cord-296347-fanlvxqs	1154	11	membrane	membrane	NN
cord-296347-fanlvxqs	1154	12	Phosphorylation	Phosphorylation	NNP
cord-296347-fanlvxqs	1154	13	meets	meet	VBZ
cord-296347-fanlvxqs	1154	14	ubiquitination	ubiquitination	NN
cord-296347-fanlvxqs	1154	15	:	:	:
cord-296347-fanlvxqs	1155	1	The	the	DT
cord-296347-fanlvxqs	1155	2	control	control	NN
cord-296347-fanlvxqs	1155	3	of	of	IN
cord-296347-fanlvxqs	1155	4	NF-[kappa]B	NF-[kappa]B	NNP
cord-296347-fanlvxqs	1155	5	activity	activity	NN
cord-296347-fanlvxqs	1155	6	A	a	NN
cord-296347-fanlvxqs	1155	7	complex	complex	NN
cord-296347-fanlvxqs	1155	8	between	between	IN
cord-296347-fanlvxqs	1155	9	peptide	peptide	NN
cord-296347-fanlvxqs	1155	10	:	:	:
cord-296347-fanlvxqs	1155	11	N	n	CD
cord-296347-fanlvxqs	1155	12	-	-	HYPH
cord-296347-fanlvxqs	1155	13	glycanase	glycanase	NN
cord-296347-fanlvxqs	1155	14	and	and	CC
cord-296347-fanlvxqs	1155	15	two	two	CD
cord-296347-fanlvxqs	1155	16	proteasome	proteasome	NN
cord-296347-fanlvxqs	1155	17	-	-	HYPH
cord-296347-fanlvxqs	1155	18	linked	link	VBN
cord-296347-fanlvxqs	1155	19	proteins	protein	NNS
cord-296347-fanlvxqs	1155	20	suggests	suggest	VBZ
cord-296347-fanlvxqs	1155	21	a	a	DT
cord-296347-fanlvxqs	1155	22	mechanism	mechanism	NN
cord-296347-fanlvxqs	1155	23	for	for	IN
cord-296347-fanlvxqs	1155	24	the	the	DT
cord-296347-fanlvxqs	1155	25	degradation	degradation	NN
cord-296347-fanlvxqs	1155	26	of	of	IN
cord-296347-fanlvxqs	1155	27	misfolded	misfolde	VBN
cord-296347-fanlvxqs	1155	28	glycoproteins	glycoprotein	NNS
cord-296347-fanlvxqs	1156	1	A	a	DT
cord-296347-fanlvxqs	1156	2	deubiquitinating	deubiquitinating	NN
cord-296347-fanlvxqs	1156	3	enzyme	enzyme	NN
cord-296347-fanlvxqs	1156	4	encoded	encode	VBN
cord-296347-fanlvxqs	1156	5	by	by	IN
cord-296347-fanlvxqs	1156	6	HSV-1	HSV-1	NNP
cord-296347-fanlvxqs	1156	7	belongs	belong	VBZ
cord-296347-fanlvxqs	1156	8	to	to	IN
cord-296347-fanlvxqs	1156	9	a	a	DT
cord-296347-fanlvxqs	1156	10	family	family	NN
cord-296347-fanlvxqs	1156	11	of	of	IN
cord-296347-fanlvxqs	1156	12	cysteine	cysteine	NN
cord-296347-fanlvxqs	1156	13	proteases	protease	NNS
cord-296347-fanlvxqs	1156	14	that	that	WDT
cord-296347-fanlvxqs	1156	15	is	be	VBZ
cord-296347-fanlvxqs	1156	16	conserved	conserve	VBN
cord-296347-fanlvxqs	1156	17	across	across	IN
cord-296347-fanlvxqs	1156	18	the	the	DT
cord-296347-fanlvxqs	1156	19	family	family	NN
cord-296347-fanlvxqs	1156	20	Herpesviridae	Herpesviridae	NNP
cord-296347-fanlvxqs	1156	21	Receptor	Receptor	NNP
cord-296347-fanlvxqs	1156	22	downregulation	downregulation	NN
cord-296347-fanlvxqs	1156	23	and	and	CC
cord-296347-fanlvxqs	1156	24	multivesicular	multivesicular	JJ
cord-296347-fanlvxqs	1156	25	-	-	HYPH
cord-296347-fanlvxqs	1156	26	body	body	NN
cord-296347-fanlvxqs	1156	27	sorting	sorting	NN
cord-296347-fanlvxqs	1157	1	NEDD8	NEDD8	NNP
cord-296347-fanlvxqs	1157	2	recruits	recruit	VBZ
cord-296347-fanlvxqs	1157	3	E2-ubiquitin	E2-ubiquitin	NNS
cord-296347-fanlvxqs	1157	4	to	to	IN
cord-296347-fanlvxqs	1157	5	SCF	SCF	NNP
cord-296347-fanlvxqs	1157	6	E3	E3	NNP
cord-296347-fanlvxqs	1157	7	ligase	ligase	NN
cord-296347-fanlvxqs	1157	8	Modulation	modulation	NN
cord-296347-fanlvxqs	1157	9	of	of	IN
cord-296347-fanlvxqs	1157	10	specific	specific	JJ
cord-296347-fanlvxqs	1157	11	surface	surface	NN
cord-296347-fanlvxqs	1157	12	receptors	receptor	NNS
cord-296347-fanlvxqs	1157	13	and	and	CC
cord-296347-fanlvxqs	1157	14	activation	activation	NN
cord-296347-fanlvxqs	1157	15	sensitization	sensitization	NN
cord-296347-fanlvxqs	1157	16	in	in	IN
cord-296347-fanlvxqs	1157	17	primary	primary	JJ
cord-296347-fanlvxqs	1157	18	resting	rest	VBG
cord-296347-fanlvxqs	1157	19	CD4þ	CD4þ	NNP
cord-296347-fanlvxqs	1157	20	T	T	NNP
cord-296347-fanlvxqs	1157	21	lymphocytes	lymphocyte	NNS
cord-296347-fanlvxqs	1157	22	by	by	IN
cord-296347-fanlvxqs	1157	23	the	the	DT
cord-296347-fanlvxqs	1157	24	Nef	Nef	NNP
cord-296347-fanlvxqs	1157	25	protein	protein	NN
cord-296347-fanlvxqs	1157	26	of	of	IN
cord-296347-fanlvxqs	1157	27	HIV-1	HIV-1	NNP
cord-296347-fanlvxqs	1158	1	The	the	DT
cord-296347-fanlvxqs	1158	2	human	human	JJ
cord-296347-fanlvxqs	1158	3	immunodeficiency	immunodeficiency	NN
cord-296347-fanlvxqs	1158	4	virus	virus	NN
cord-296347-fanlvxqs	1158	5	type	type	NN
cord-296347-fanlvxqs	1158	6	1	1	CD
cord-296347-fanlvxqs	1159	1	(	(	-LRB-
cord-296347-fanlvxqs	1160	1	HIV-1	HIV-1	NNP
cord-296347-fanlvxqs	1160	2	)	)	-RRB-
cord-296347-fanlvxqs	1160	3	Vpu	Vpu	NNP
cord-296347-fanlvxqs	1160	4	protein	protein	NN
cord-296347-fanlvxqs	1160	5	interferes	interfere	VBZ
cord-296347-fanlvxqs	1160	6	with	with	IN
cord-296347-fanlvxqs	1160	7	an	an	DT
cord-296347-fanlvxqs	1160	8	early	early	JJ
cord-296347-fanlvxqs	1160	9	step	step	NN
cord-296347-fanlvxqs	1160	10	in	in	IN
cord-296347-fanlvxqs	1160	11	the	the	DT
cord-296347-fanlvxqs	1160	12	biosynthesis	biosynthesis	NN
cord-296347-fanlvxqs	1160	13	of	of	IN
cord-296347-fanlvxqs	1160	14	major	major	JJ
cord-296347-fanlvxqs	1160	15	histocompatibility	histocompatibility	NN
cord-296347-fanlvxqs	1160	16	complex	complex	NN
cord-296347-fanlvxqs	1160	17	(	(	-LRB-
cord-296347-fanlvxqs	1160	18	MHC	MHC	NNP
cord-296347-fanlvxqs	1160	19	)	)	-RRB-
cord-296347-fanlvxqs	1160	20	class	class	NN
cord-296347-fanlvxqs	1161	1	I	-PRON-	PRP
cord-296347-fanlvxqs	1161	2	molecules	molecule	VBZ
cord-296347-fanlvxqs	1161	3	Human	human	JJ
cord-296347-fanlvxqs	1161	4	HRD1	HRD1	NNP
cord-296347-fanlvxqs	1162	1	is	be	VBZ
cord-296347-fanlvxqs	1162	2	an	an	DT
cord-296347-fanlvxqs	1162	3	E3	e3	NN
cord-296347-fanlvxqs	1162	4	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1162	5	ligase	ligase	NN
cord-296347-fanlvxqs	1162	6	involved	involve	VBN
cord-296347-fanlvxqs	1162	7	in	in	IN
cord-296347-fanlvxqs	1162	8	degradation	degradation	NN
cord-296347-fanlvxqs	1162	9	of	of	IN
cord-296347-fanlvxqs	1162	10	proteins	protein	NNS
cord-296347-fanlvxqs	1162	11	from	from	IN
cord-296347-fanlvxqs	1162	12	the	the	DT
cord-296347-fanlvxqs	1162	13	endoplasmic	endoplasmic	NN
cord-296347-fanlvxqs	1162	14	reticulum	reticulum	NN
cord-296347-fanlvxqs	1163	1	The	the	DT
cord-296347-fanlvxqs	1163	2	Shigella	Shigella	NNP
cord-296347-fanlvxqs	1163	3	flexneri	flexneri	NN
cord-296347-fanlvxqs	1163	4	effector	effector	NN
cord-296347-fanlvxqs	1163	5	OspG	OspG	NNP
cord-296347-fanlvxqs	1163	6	interferes	interfere	VBZ
cord-296347-fanlvxqs	1163	7	with	with	IN
cord-296347-fanlvxqs	1163	8	innate	innate	JJ
cord-296347-fanlvxqs	1163	9	immune	immune	JJ
cord-296347-fanlvxqs	1163	10	responses	response	NNS
cord-296347-fanlvxqs	1163	11	by	by	IN
cord-296347-fanlvxqs	1163	12	targeting	target	VBG
cord-296347-fanlvxqs	1163	13	ubiquitinconjugating	ubiquitinconjugating	NN
cord-296347-fanlvxqs	1163	14	enzymes	enzyme	NNS
cord-296347-fanlvxqs	1164	1	The	the	DT
cord-296347-fanlvxqs	1164	2	Png1-Rad23	Png1-Rad23	NNP
cord-296347-fanlvxqs	1164	3	complex	complex	NN
cord-296347-fanlvxqs	1164	4	regulates	regulate	VBZ
cord-296347-fanlvxqs	1164	5	glycoprotein	glycoprotein	NN
cord-296347-fanlvxqs	1164	6	turnover	turnover	NN
cord-296347-fanlvxqs	1164	7	Ube1L	ube1l	NN
cord-296347-fanlvxqs	1164	8	and	and	CC
cord-296347-fanlvxqs	1164	9	protein	protein	NN
cord-296347-fanlvxqs	1164	10	ISGylation	ISGylation	NNP
cord-296347-fanlvxqs	1164	11	are	be	VBP
cord-296347-fanlvxqs	1164	12	not	not	RB
cord-296347-fanlvxqs	1164	13	essential	essential	JJ
cord-296347-fanlvxqs	1164	14	for	for	IN
cord-296347-fanlvxqs	1165	1	alpha	alpha	NN
cord-296347-fanlvxqs	1165	2	/	/	SYM
cord-296347-fanlvxqs	1165	3	beta	beta	NN
cord-296347-fanlvxqs	1165	4	interferon	interferon	NN
cord-296347-fanlvxqs	1165	5	signaling	signal	VBG
cord-296347-fanlvxqs	1165	6	Monovalent	Monovalent	NNP
cord-296347-fanlvxqs	1165	7	ligation	ligation	NN
cord-296347-fanlvxqs	1165	8	of	of	IN
cord-296347-fanlvxqs	1165	9	the	the	DT
cord-296347-fanlvxqs	1165	10	B	b	NN
cord-296347-fanlvxqs	1165	11	cell	cell	NN
cord-296347-fanlvxqs	1165	12	receptor	receptor	NN
cord-296347-fanlvxqs	1165	13	induces	induce	VBZ
cord-296347-fanlvxqs	1165	14	receptor	receptor	NN
cord-296347-fanlvxqs	1165	15	activation	activation	NN
cord-296347-fanlvxqs	1165	16	but	but	CC
cord-296347-fanlvxqs	1165	17	fails	fail	VBZ
cord-296347-fanlvxqs	1165	18	to	to	TO
cord-296347-fanlvxqs	1165	19	promote	promote	VB
cord-296347-fanlvxqs	1165	20	antigen	antigen	NN
cord-296347-fanlvxqs	1165	21	presentation	presentation	NN
cord-296347-fanlvxqs	1165	22	Intracellular	Intracellular	NNP
cord-296347-fanlvxqs	1165	23	membrane	membrane	NN
cord-296347-fanlvxqs	1165	24	traffic	traffic	NN
cord-296347-fanlvxqs	1165	25	of	of	IN
cord-296347-fanlvxqs	1165	26	human	human	JJ
cord-296347-fanlvxqs	1165	27	immunodeficiency	immunodeficiency	NN
cord-296347-fanlvxqs	1165	28	virus	virus	NN
cord-296347-fanlvxqs	1165	29	type	type	NN
cord-296347-fanlvxqs	1165	30	1	1	CD
cord-296347-fanlvxqs	1165	31	envelope	envelope	NN
cord-296347-fanlvxqs	1165	32	glycoproteins	glycoprotein	NNS
cord-296347-fanlvxqs	1165	33	:	:	:
cord-296347-fanlvxqs	1165	34	Vpu	Vpu	NNP
cord-296347-fanlvxqs	1165	35	liberates	liberate	VBZ
cord-296347-fanlvxqs	1165	36	Golgi	golgi	NN
cord-296347-fanlvxqs	1165	37	-	-	HYPH
cord-296347-fanlvxqs	1165	38	targeted	target	VBN
cord-296347-fanlvxqs	1165	39	gp160	gp160	NN
cord-296347-fanlvxqs	1165	40	from	from	IN
cord-296347-fanlvxqs	1165	41	CD4-dependent	cd4-dependent	JJ
cord-296347-fanlvxqs	1165	42	retention	retention	NN
cord-296347-fanlvxqs	1165	43	in	in	IN
cord-296347-fanlvxqs	1165	44	the	the	DT
cord-296347-fanlvxqs	1165	45	endoplasmic	endoplasmic	NN
cord-296347-fanlvxqs	1165	46	reticulum	reticulum	NN
cord-296347-fanlvxqs	1165	47	T	T	NNP
cord-296347-fanlvxqs	1165	48	cells	cell	NNS
cord-296347-fanlvxqs	1165	49	and	and	CC
cord-296347-fanlvxqs	1165	50	viral	viral	JJ
cord-296347-fanlvxqs	1165	51	persistence	persistence	NN
cord-296347-fanlvxqs	1165	52	:	:	:
cord-296347-fanlvxqs	1166	1	Lessons	lesson	NNS
cord-296347-fanlvxqs	1166	2	from	from	IN
cord-296347-fanlvxqs	1166	3	diverse	diverse	JJ
cord-296347-fanlvxqs	1166	4	infections	infection	NNS
cord-296347-fanlvxqs	1167	1	The	the	DT
cord-296347-fanlvxqs	1167	2	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1167	3	-	-	HYPH
cord-296347-fanlvxqs	1167	4	proteasome	proteasome	VBN
cord-296347-fanlvxqs	1167	5	system	system	NN
cord-296347-fanlvxqs	1167	6	in	in	IN
cord-296347-fanlvxqs	1167	7	HIV	HIV	NNP
cord-296347-fanlvxqs	1167	8	replication	replication	NN
cord-296347-fanlvxqs	1167	9	:	:	:
cord-296347-fanlvxqs	1167	10	Potential	potential	JJ
cord-296347-fanlvxqs	1167	11	targets	target	NNS
cord-296347-fanlvxqs	1167	12	for	for	IN
cord-296347-fanlvxqs	1167	13	antiretroviral	antiretroviral	JJ
cord-296347-fanlvxqs	1167	14	therapy	therapy	NN
cord-296347-fanlvxqs	1168	1	The	the	DT
cord-296347-fanlvxqs	1168	2	proteasome	proteasome	NN
cord-296347-fanlvxqs	1168	3	and	and	CC
cord-296347-fanlvxqs	1168	4	MHC	MHC	NNP
cord-296347-fanlvxqs	1168	5	class	class	NN
cord-296347-fanlvxqs	1168	6	I	-PRON-	PRP
cord-296347-fanlvxqs	1168	7	antigen	antigen	NN
cord-296347-fanlvxqs	1168	8	processing	processing	NN
cord-296347-fanlvxqs	1168	9	Proteasome	Proteasome	NNP
cord-296347-fanlvxqs	1168	10	and	and	CC
cord-296347-fanlvxqs	1168	11	peptidase	peptidase	NN
cord-296347-fanlvxqs	1168	12	function	function	NN
cord-296347-fanlvxqs	1168	13	in	in	IN
cord-296347-fanlvxqs	1168	14	MHC	MHC	NNP
cord-296347-fanlvxqs	1168	15	-	-	HYPH
cord-296347-fanlvxqs	1168	16	class	class	NN
cord-296347-fanlvxqs	1168	17	-	-	HYPH
cord-296347-fanlvxqs	1168	18	Imediated	imediate	VBN
cord-296347-fanlvxqs	1168	19	antigen	antigen	NN
cord-296347-fanlvxqs	1168	20	presentation	presentation	NN
cord-296347-fanlvxqs	1168	21	Reexamination	reexamination	NN
cord-296347-fanlvxqs	1168	22	of	of	IN
cord-296347-fanlvxqs	1168	23	the	the	DT
cord-296347-fanlvxqs	1168	24	role	role	NN
cord-296347-fanlvxqs	1168	25	of	of	IN
cord-296347-fanlvxqs	1168	26	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1168	27	-	-	HYPH
cord-296347-fanlvxqs	1168	28	like	like	JJ
cord-296347-fanlvxqs	1168	29	modifier	modifier	NN
cord-296347-fanlvxqs	1168	30	ISG15	isg15	NN
cord-296347-fanlvxqs	1168	31	in	in	IN
cord-296347-fanlvxqs	1168	32	the	the	DT
cord-296347-fanlvxqs	1168	33	phenotype	phenotype	NN
cord-296347-fanlvxqs	1168	34	of	of	IN
cord-296347-fanlvxqs	1168	35	UBP43-deficient	ubp43-deficient	CD
cord-296347-fanlvxqs	1168	36	mice	mouse	NNS
cord-296347-fanlvxqs	1168	37	Der1	Der1	NNP
cord-296347-fanlvxqs	1168	38	,	,	,
cord-296347-fanlvxqs	1168	39	a	a	DT
cord-296347-fanlvxqs	1168	40	novel	novel	JJ
cord-296347-fanlvxqs	1168	41	protein	protein	NN
cord-296347-fanlvxqs	1168	42	specifically	specifically	RB
cord-296347-fanlvxqs	1168	43	required	require	VBN
cord-296347-fanlvxqs	1168	44	for	for	IN
cord-296347-fanlvxqs	1168	45	endoplasmic	endoplasmic	NN
cord-296347-fanlvxqs	1168	46	reticulum	reticulum	NN
cord-296347-fanlvxqs	1168	47	degradation	degradation	NN
cord-296347-fanlvxqs	1168	48	in	in	IN
cord-296347-fanlvxqs	1168	49	yeast	yeast	NN
cord-296347-fanlvxqs	1169	1	The	the	DT
cord-296347-fanlvxqs	1169	2	substrate	substrate	NN
cord-296347-fanlvxqs	1169	3	translocation	translocation	NN
cord-296347-fanlvxqs	1169	4	channel	channel	NN
cord-296347-fanlvxqs	1169	5	of	of	IN
cord-296347-fanlvxqs	1169	6	the	the	DT
cord-296347-fanlvxqs	1169	7	proteasome	proteasome	NN
cord-296347-fanlvxqs	1169	8	Herp	Herp	NNP
cord-296347-fanlvxqs	1169	9	,	,	,
cord-296347-fanlvxqs	1169	10	a	a	DT
cord-296347-fanlvxqs	1169	11	new	new	JJ
cord-296347-fanlvxqs	1169	12	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1169	13	-	-	HYPH
cord-296347-fanlvxqs	1169	14	like	like	JJ
cord-296347-fanlvxqs	1169	15	membrane	membrane	NN
cord-296347-fanlvxqs	1169	16	protein	protein	NN
cord-296347-fanlvxqs	1169	17	induced	induce	VBN
cord-296347-fanlvxqs	1169	18	by	by	IN
cord-296347-fanlvxqs	1169	19	endoplasmic	endoplasmic	NN
cord-296347-fanlvxqs	1169	20	reticulum	reticulum	NN
cord-296347-fanlvxqs	1169	21	stress	stress	NN
cord-296347-fanlvxqs	1169	22	Gamma	Gamma	NNP
cord-296347-fanlvxqs	1169	23	-	-	HYPH
cord-296347-fanlvxqs	1169	24	secretase	secretase	NNP
cord-296347-fanlvxqs	1169	25	:	:	:
cord-296347-fanlvxqs	1169	26	Proteasome	Proteasome	NNP
cord-296347-fanlvxqs	1169	27	of	of	IN
cord-296347-fanlvxqs	1169	28	the	the	DT
cord-296347-fanlvxqs	1169	29	membrane	membrane	NN
cord-296347-fanlvxqs	1169	30	?	?	.
cord-296347-fanlvxqs	1170	1	Hepatitis	Hepatitis	NNP
cord-296347-fanlvxqs	1170	2	C	C	NNP
cord-296347-fanlvxqs	1170	3	virus	virus	NN
cord-296347-fanlvxqs	1170	4	core	core	NN
cord-296347-fanlvxqs	1170	5	protein	protein	NN
cord-296347-fanlvxqs	1170	6	inhibits	inhibit	VBZ
cord-296347-fanlvxqs	1170	7	mitochondrial	mitochondrial	JJ
cord-296347-fanlvxqs	1170	8	electron	electron	NN
cord-296347-fanlvxqs	1170	9	transport	transport	NN
cord-296347-fanlvxqs	1170	10	and	and	CC
cord-296347-fanlvxqs	1170	11	increases	increase	VBZ
cord-296347-fanlvxqs	1170	12	reactive	reactive	JJ
cord-296347-fanlvxqs	1170	13	oxygen	oxygen	NN
cord-296347-fanlvxqs	1170	14	species	specie	NNS
cord-296347-fanlvxqs	1171	1	(	(	-LRB-
cord-296347-fanlvxqs	1171	2	ROS	ROS	NNP
cord-296347-fanlvxqs	1171	3	)	)	-RRB-
cord-296347-fanlvxqs	1171	4	production	production	NN
cord-296347-fanlvxqs	1171	5	Differential	differential	JJ
cord-296347-fanlvxqs	1171	6	effects	effect	NNS
cord-296347-fanlvxqs	1171	7	of	of	IN
cord-296347-fanlvxqs	1171	8	inhibitors	inhibitor	NNS
cord-296347-fanlvxqs	1171	9	on	on	IN
cord-296347-fanlvxqs	1171	10	the	the	DT
cord-296347-fanlvxqs	1171	11	gammasecretase	gammasecretase	NN
cord-296347-fanlvxqs	1171	12	complex	complex	NN
cord-296347-fanlvxqs	1171	13	.	.	.
cord-296347-fanlvxqs	1172	1	Mechanistic	mechanistic	JJ
cord-296347-fanlvxqs	1172	2	implications	implication	NNS
cord-296347-fanlvxqs	1173	1	Structural	structural	JJ
cord-296347-fanlvxqs	1173	2	and	and	CC
cord-296347-fanlvxqs	1173	3	functional	functional	JJ
cord-296347-fanlvxqs	1173	4	organization	organization	NN
cord-296347-fanlvxqs	1173	5	of	of	IN
cord-296347-fanlvxqs	1173	6	the	the	DT
cord-296347-fanlvxqs	1173	7	ESCRT	ESCRT	NNP
cord-296347-fanlvxqs	1174	1	-I	-i	DT
cord-296347-fanlvxqs	1174	2	trafficking	traffic	VBG
cord-296347-fanlvxqs	1174	3	complex	complex	NN
cord-296347-fanlvxqs	1174	4	For	for	IN
cord-296347-fanlvxqs	1174	5	whom	whom	WP
cord-296347-fanlvxqs	1174	6	the	the	DT
cord-296347-fanlvxqs	1174	7	bell	bell	NNP
cord-296347-fanlvxqs	1174	8	tolls	toll	NNS
cord-296347-fanlvxqs	1174	9	:	:	:
cord-296347-fanlvxqs	1174	10	Protein	protein	NN
cord-296347-fanlvxqs	1174	11	quality	quality	NN
cord-296347-fanlvxqs	1174	12	control	control	NN
cord-296347-fanlvxqs	1174	13	of	of	IN
cord-296347-fanlvxqs	1174	14	the	the	DT
cord-296347-fanlvxqs	1174	15	endoplasmic	endoplasmic	NN
cord-296347-fanlvxqs	1174	16	reticulum	reticulum	NN
cord-296347-fanlvxqs	1174	17	and	and	CC
cord-296347-fanlvxqs	1174	18	the	the	DT
cord-296347-fanlvxqs	1174	19	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1174	20	-	-	HYPH
cord-296347-fanlvxqs	1174	21	proteasome	proteasome	VBN
cord-296347-fanlvxqs	1174	22	connection	connection	NN
cord-296347-fanlvxqs	1174	23	Differential	differential	NN
cord-296347-fanlvxqs	1174	24	localization	localization	NN
cord-296347-fanlvxqs	1174	25	and	and	CC
cord-296347-fanlvxqs	1174	26	identification	identification	NN
cord-296347-fanlvxqs	1174	27	of	of	IN
cord-296347-fanlvxqs	1174	28	a	a	DT
cord-296347-fanlvxqs	1174	29	critical	critical	JJ
cord-296347-fanlvxqs	1174	30	aspartate	aspartate	NN
cord-296347-fanlvxqs	1174	31	suggest	suggest	VBP
cord-296347-fanlvxqs	1174	32	non	non	JJ
cord-296347-fanlvxqs	1174	33	-	-	JJ
cord-296347-fanlvxqs	1174	34	redundant	redundant	JJ
cord-296347-fanlvxqs	1174	35	proteolytic	proteolytic	JJ
cord-296347-fanlvxqs	1174	36	functions	function	NNS
cord-296347-fanlvxqs	1174	37	of	of	IN
cord-296347-fanlvxqs	1174	38	the	the	DT
cord-296347-fanlvxqs	1174	39	presenilin	presenilin	NN
cord-296347-fanlvxqs	1174	40	in	in	IN
cord-296347-fanlvxqs	1174	41	homologues	homologue	NNS
cord-296347-fanlvxqs	1174	42	SPPL2b	SPPL2b	NNS
cord-296347-fanlvxqs	1174	43	and	and	CC
cord-296347-fanlvxqs	1174	44	SPPL3	sppl3	NN
cord-296347-fanlvxqs	1174	45	Membrane	membrane	NN
cord-296347-fanlvxqs	1174	46	topology	topology	NN
cord-296347-fanlvxqs	1174	47	of	of	IN
cord-296347-fanlvxqs	1174	48	the	the	DT
cord-296347-fanlvxqs	1174	49	yeast	yeast	NN
cord-296347-fanlvxqs	1174	50	endoplasmic	endoplasmic	NN
cord-296347-fanlvxqs	1174	51	reticulum	reticulum	NN
cord-296347-fanlvxqs	1174	52	-	-	HYPH
cord-296347-fanlvxqs	1174	53	localized	localize	VBN
cord-296347-fanlvxqs	1174	54	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1174	55	ligase	ligase	NN
cord-296347-fanlvxqs	1174	56	Doa10	Doa10	NNP
cord-296347-fanlvxqs	1174	57	and	and	CC
cord-296347-fanlvxqs	1174	58	comparison	comparison	NN
cord-296347-fanlvxqs	1174	59	with	with	IN
cord-296347-fanlvxqs	1174	60	its	-PRON-	PRP$
cord-296347-fanlvxqs	1174	61	human	human	JJ
cord-296347-fanlvxqs	1174	62	ortholog	ortholog	NN
cord-296347-fanlvxqs	1174	63	TEB4	TEB4	NNP
cord-296347-fanlvxqs	1174	64	(	(	-LRB-
cord-296347-fanlvxqs	1174	65	MARCH	MARCH	NNP
cord-296347-fanlvxqs	1174	66	-	-	HYPH
cord-296347-fanlvxqs	1174	67	VI	VI	NNP
cord-296347-fanlvxqs	1174	68	)	)	-RRB-
cord-296347-fanlvxqs	1175	1	The	the	DT
cord-296347-fanlvxqs	1175	2	components	component	NNS
cord-296347-fanlvxqs	1175	3	of	of	IN
cord-296347-fanlvxqs	1175	4	the	the	DT
cord-296347-fanlvxqs	1175	5	proteasome	proteasome	NN
cord-296347-fanlvxqs	1175	6	system	system	NN
cord-296347-fanlvxqs	1175	7	and	and	CC
cord-296347-fanlvxqs	1175	8	their	-PRON-	PRP$
cord-296347-fanlvxqs	1175	9	role	role	NN
cord-296347-fanlvxqs	1175	10	in	in	IN
cord-296347-fanlvxqs	1175	11	MHC	MHC	NNP
cord-296347-fanlvxqs	1175	12	class	class	NN
cord-296347-fanlvxqs	1175	13	I	-PRON-	PRP
cord-296347-fanlvxqs	1175	14	antigen	antigen	NN
cord-296347-fanlvxqs	1175	15	processing	process	VBG
cord-296347-fanlvxqs	1175	16	Temporal	temporal	JJ
cord-296347-fanlvxqs	1175	17	regulation	regulation	NN
cord-296347-fanlvxqs	1175	18	of	of	IN
cord-296347-fanlvxqs	1175	19	salmonella	salmonella	NN
cord-296347-fanlvxqs	1175	20	virulence	virulence	NN
cord-296347-fanlvxqs	1175	21	effector	effector	NN
cord-296347-fanlvxqs	1175	22	function	function	NN
cord-296347-fanlvxqs	1175	23	by	by	IN
cord-296347-fanlvxqs	1175	24	proteasome	proteasome	NN
cord-296347-fanlvxqs	1175	25	-	-	HYPH
cord-296347-fanlvxqs	1175	26	dependent	dependent	JJ
cord-296347-fanlvxqs	1175	27	protein	protein	NN
cord-296347-fanlvxqs	1175	28	degradation	degradation	NN
cord-296347-fanlvxqs	1176	1	A	a	DT
cord-296347-fanlvxqs	1176	2	new	new	JJ
cord-296347-fanlvxqs	1176	3	self	self	NN
cord-296347-fanlvxqs	1176	4	:	:	:
cord-296347-fanlvxqs	1176	5	MHC	MHC	NNP
cord-296347-fanlvxqs	1176	6	-	-	HYPH
cord-296347-fanlvxqs	1176	7	class	class	NN
cord-296347-fanlvxqs	1176	8	-	-	HYPH
cord-296347-fanlvxqs	1176	9	I	i	NN
cord-296347-fanlvxqs	1176	10	-	-	HYPH
cord-296347-fanlvxqs	1176	11	independent	independent	JJ
cord-296347-fanlvxqs	1176	12	natural	natural	JJ
cord-296347-fanlvxqs	1176	13	-	-	HYPH
cord-296347-fanlvxqs	1176	14	killer	killer	NN
cord-296347-fanlvxqs	1176	15	-	-	HYPH
cord-296347-fanlvxqs	1176	16	cell	cell	NN
cord-296347-fanlvxqs	1176	17	self	self	NN
cord-296347-fanlvxqs	1176	18	-	-	HYPH
cord-296347-fanlvxqs	1176	19	tolerance	tolerance	NN
cord-296347-fanlvxqs	1176	20	Role	role	NN
cord-296347-fanlvxqs	1176	21	of	of	IN
cord-296347-fanlvxqs	1176	22	interferon	interferon	NN
cord-296347-fanlvxqs	1176	23	-	-	HYPH
cord-296347-fanlvxqs	1176	24	stimulated	stimulate	VBN
cord-296347-fanlvxqs	1176	25	gene	gene	NN
cord-296347-fanlvxqs	1176	26	ISG-15	ISG-15	NNP
cord-296347-fanlvxqs	1177	1	in	in	IN
cord-296347-fanlvxqs	1177	2	the	the	DT
cord-296347-fanlvxqs	1177	3	interferonomega	interferonomega	NN
cord-296347-fanlvxqs	1177	4	-	-	HYPH
cord-296347-fanlvxqs	1177	5	mediated	mediate	VBN
cord-296347-fanlvxqs	1177	6	inhibition	inhibition	NN
cord-296347-fanlvxqs	1177	7	of	of	IN
cord-296347-fanlvxqs	1177	8	human	human	JJ
cord-296347-fanlvxqs	1177	9	immunodeficiency	immunodeficiency	NN
cord-296347-fanlvxqs	1177	10	virus	virus	NN
cord-296347-fanlvxqs	1177	11	replication	replication	NN
cord-296347-fanlvxqs	1177	12	Molecular	Molecular	NNP
cord-296347-fanlvxqs	1177	13	mechanism	mechanism	NN
cord-296347-fanlvxqs	1177	14	and	and	CC
cord-296347-fanlvxqs	1177	15	structural	structural	JJ
cord-296347-fanlvxqs	1177	16	aspects	aspect	NNS
cord-296347-fanlvxqs	1177	17	of	of	IN
cord-296347-fanlvxqs	1177	18	transporter	transporter	NN
cord-296347-fanlvxqs	1177	19	associated	associate	VBN
cord-296347-fanlvxqs	1177	20	with	with	IN
cord-296347-fanlvxqs	1177	21	antigen	antigen	NN
cord-296347-fanlvxqs	1177	22	processing	processing	NN
cord-296347-fanlvxqs	1177	23	inhibition	inhibition	NN
cord-296347-fanlvxqs	1177	24	by	by	IN
cord-296347-fanlvxqs	1177	25	the	the	DT
cord-296347-fanlvxqs	1177	26	cytomegalovirus	cytomegalovirus	NNP
cord-296347-fanlvxqs	1177	27	protein	protein	NN
cord-296347-fanlvxqs	1177	28	US6	US6	NNP
cord-296347-fanlvxqs	1177	29	Human	Human	NNP
cord-296347-fanlvxqs	1177	30	immunodeficiency	immunodeficiency	NN
cord-296347-fanlvxqs	1177	31	virus	virus	NN
cord-296347-fanlvxqs	1177	32	type	type	NN
cord-296347-fanlvxqs	1177	33	1	1	CD
cord-296347-fanlvxqs	1177	34	Nef	Nef	NNP
cord-296347-fanlvxqs	1177	35	mediates	mediate	VBZ
cord-296347-fanlvxqs	1177	36	sustained	sustained	JJ
cord-296347-fanlvxqs	1177	37	membrane	membrane	NN
cord-296347-fanlvxqs	1177	38	expression	expression	NN
cord-296347-fanlvxqs	1177	39	of	of	IN
cord-296347-fanlvxqs	1177	40	tumor	tumor	NN
cord-296347-fanlvxqs	1177	41	necrosis	necrosis	NN
cord-296347-fanlvxqs	1177	42	factor	factor	NN
cord-296347-fanlvxqs	1177	43	and	and	CC
cord-296347-fanlvxqs	1177	44	the	the	DT
cord-296347-fanlvxqs	1177	45	related	related	JJ
cord-296347-fanlvxqs	1177	46	cytokine	cytokine	NN
cord-296347-fanlvxqs	1177	47	LIGHT	light	NN
cord-296347-fanlvxqs	1177	48	on	on	IN
cord-296347-fanlvxqs	1177	49	activated	activate	VBN
cord-296347-fanlvxqs	1177	50	T	t	NN
cord-296347-fanlvxqs	1177	51	cells	cell	NNS
cord-296347-fanlvxqs	1177	52	Cell	cell	NN
cord-296347-fanlvxqs	1177	53	-	-	HYPH
cord-296347-fanlvxqs	1177	54	surface	surface	NN
cord-296347-fanlvxqs	1177	55	expression	expression	NN
cord-296347-fanlvxqs	1177	56	of	of	IN
cord-296347-fanlvxqs	1177	57	CD4	CD4	NNP
cord-296347-fanlvxqs	1177	58	reduces	reduce	VBZ
cord-296347-fanlvxqs	1177	59	HIV-1	HIV-1	NNP
cord-296347-fanlvxqs	1177	60	infectivity	infectivity	NN
cord-296347-fanlvxqs	1177	61	by	by	IN
cord-296347-fanlvxqs	1177	62	blocking	block	VBG
cord-296347-fanlvxqs	1177	63	Env	Env	NNP
cord-296347-fanlvxqs	1177	64	incorporation	incorporation	NN
cord-296347-fanlvxqs	1177	65	in	in	IN
cord-296347-fanlvxqs	1177	66	a	a	DT
cord-296347-fanlvxqs	1177	67	Nef	Nef	NNP
cord-296347-fanlvxqs	1177	68	-	-	HYPH
cord-296347-fanlvxqs	1177	69	and	and	CC
cord-296347-fanlvxqs	1177	70	Vpu	Vpu	NNP
cord-296347-fanlvxqs	1177	71	-	-	HYPH
cord-296347-fanlvxqs	1177	72	inhibitable	inhibitable	JJ
cord-296347-fanlvxqs	1177	73	manner	manner	NN
cord-296347-fanlvxqs	1178	1	Exclusive	exclusive	JJ
cord-296347-fanlvxqs	1178	2	ubiquitination	ubiquitination	NN
cord-296347-fanlvxqs	1178	3	and	and	CC
cord-296347-fanlvxqs	1178	4	sumoylation	sumoylation	NN
cord-296347-fanlvxqs	1178	5	on	on	IN
cord-296347-fanlvxqs	1178	6	overlapping	overlap	VBG
cord-296347-fanlvxqs	1178	7	lysine	lysine	NN
cord-296347-fanlvxqs	1178	8	residues	residue	NNS
cord-296347-fanlvxqs	1178	9	mediate	mediate	VBP
cord-296347-fanlvxqs	1178	10	NF	NF	NNP
cord-296347-fanlvxqs	1178	11	-	-	HYPH
cord-296347-fanlvxqs	1178	12	kappaB	kappaB	NNP
cord-296347-fanlvxqs	1178	13	activation	activation	NN
cord-296347-fanlvxqs	1178	14	by	by	IN
cord-296347-fanlvxqs	1178	15	the	the	DT
cord-296347-fanlvxqs	1178	16	human	human	JJ
cord-296347-fanlvxqs	1178	17	T	t	NN
cord-296347-fanlvxqs	1178	18	-	-	HYPH
cord-296347-fanlvxqs	1178	19	cell	cell	NN
cord-296347-fanlvxqs	1178	20	leukemia	leukemia	NN
cord-296347-fanlvxqs	1178	21	virus	virus	NN
cord-296347-fanlvxqs	1178	22	tax	tax	NN
cord-296347-fanlvxqs	1178	23	oncoprotein	oncoprotein	NNP
cord-296347-fanlvxqs	1178	24	NK	NK	NNP
cord-296347-fanlvxqs	1178	25	cell	cell	NN
cord-296347-fanlvxqs	1178	26	recognition	recognition	NN
cord-296347-fanlvxqs	1178	27	Nef	Nef	NNP
cord-296347-fanlvxqs	1178	28	interacts	interact	VBZ
cord-296347-fanlvxqs	1178	29	with	with	IN
cord-296347-fanlvxqs	1178	30	the	the	DT
cord-296347-fanlvxqs	1178	31	mu	mu	NNP
cord-296347-fanlvxqs	1178	32	subunit	subunit	NN
cord-296347-fanlvxqs	1178	33	of	of	IN
cord-296347-fanlvxqs	1178	34	clathrin	clathrin	NN
cord-296347-fanlvxqs	1178	35	adaptor	adaptor	NN
cord-296347-fanlvxqs	1178	36	complexes	complex	NNS
cord-296347-fanlvxqs	1178	37	and	and	CC
cord-296347-fanlvxqs	1178	38	reveals	reveal	VBZ
cord-296347-fanlvxqs	1178	39	a	a	DT
cord-296347-fanlvxqs	1178	40	cryptic	cryptic	JJ
cord-296347-fanlvxqs	1178	41	sorting	sorting	NN
cord-296347-fanlvxqs	1178	42	signal	signal	NN
cord-296347-fanlvxqs	1178	43	in	in	IN
cord-296347-fanlvxqs	1178	44	MHC	MHC	NNP
cord-296347-fanlvxqs	1179	1	I	-PRON-	PRP
cord-296347-fanlvxqs	1179	2	molecules	molecule	VBZ
cord-296347-fanlvxqs	1179	3	Determinant	Determinant	NNP
cord-296347-fanlvxqs	1179	4	for	for	IN
cord-296347-fanlvxqs	1179	5	endoplasmic	endoplasmic	NN
cord-296347-fanlvxqs	1179	6	reticulum	reticulum	NN
cord-296347-fanlvxqs	1179	7	retention	retention	NN
cord-296347-fanlvxqs	1179	8	in	in	IN
cord-296347-fanlvxqs	1179	9	the	the	DT
cord-296347-fanlvxqs	1179	10	luminal	luminal	JJ
cord-296347-fanlvxqs	1179	11	domain	domain	NN
cord-296347-fanlvxqs	1179	12	of	of	IN
cord-296347-fanlvxqs	1179	13	the	the	DT
cord-296347-fanlvxqs	1179	14	human	human	JJ
cord-296347-fanlvxqs	1179	15	cytomegalovirus	cytomegalovirus	NN
cord-296347-fanlvxqs	1179	16	US3	US3	NNP
cord-296347-fanlvxqs	1179	17	glycoprotein	glycoprotein	NN
cord-296347-fanlvxqs	1180	1	The	the	DT
cord-296347-fanlvxqs	1180	2	human	human	JJ
cord-296347-fanlvxqs	1180	3	cytomegalovirus	cytomegalovirus	NN
cord-296347-fanlvxqs	1180	4	US6	US6	NNP
cord-296347-fanlvxqs	1180	5	glycoprotein	glycoprotein	NN
cord-296347-fanlvxqs	1180	6	inhibits	inhibit	VBZ
cord-296347-fanlvxqs	1180	7	transporter	transporter	NN
cord-296347-fanlvxqs	1180	8	associated	associate	VBN
cord-296347-fanlvxqs	1180	9	with	with	IN
cord-296347-fanlvxqs	1180	10	antigen	antigen	NN
cord-296347-fanlvxqs	1180	11	processing	processing	NN
cord-296347-fanlvxqs	1180	12	-	-	HYPH
cord-296347-fanlvxqs	1180	13	dependent	dependent	JJ
cord-296347-fanlvxqs	1180	14	peptide	peptide	NN
cord-296347-fanlvxqs	1180	15	translocation	translocation	NN
cord-296347-fanlvxqs	1180	16	Downregulation	Downregulation	NNP
cord-296347-fanlvxqs	1180	17	of	of	IN
cord-296347-fanlvxqs	1180	18	cell	cell	NN
cord-296347-fanlvxqs	1180	19	surface	surface	NN
cord-296347-fanlvxqs	1180	20	receptors	receptor	NNS
cord-296347-fanlvxqs	1180	21	by	by	IN
cord-296347-fanlvxqs	1180	22	the	the	DT
cord-296347-fanlvxqs	1180	23	K3	K3	NNP
cord-296347-fanlvxqs	1180	24	family	family	NN
cord-296347-fanlvxqs	1180	25	of	of	IN
cord-296347-fanlvxqs	1180	26	viral	viral	JJ
cord-296347-fanlvxqs	1180	27	and	and	CC
cord-296347-fanlvxqs	1180	28	cellular	cellular	JJ
cord-296347-fanlvxqs	1180	29	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1180	30	E3	e3	NN
cord-296347-fanlvxqs	1180	31	ligases	ligase	NNS
cord-296347-fanlvxqs	1180	32	Requirements	requirement	NNS
cord-296347-fanlvxqs	1180	33	for	for	IN
cord-296347-fanlvxqs	1180	34	signal	signal	NN
cord-296347-fanlvxqs	1180	35	peptide	peptide	NN
cord-296347-fanlvxqs	1180	36	peptidase	peptidase	NN
cord-296347-fanlvxqs	1180	37	-	-	HYPH
cord-296347-fanlvxqs	1180	38	catalyzed	catalyze	VBN
cord-296347-fanlvxqs	1180	39	intramembrane	intramembrane	NNP
cord-296347-fanlvxqs	1180	40	proteolysis	proteolysis	NN
cord-296347-fanlvxqs	1181	1	On	on	IN
cord-296347-fanlvxqs	1181	2	the	the	DT
cord-296347-fanlvxqs	1181	3	mechanism	mechanism	NN
cord-296347-fanlvxqs	1181	4	of	of	IN
cord-296347-fanlvxqs	1181	5	SPP	spp	NN
cord-296347-fanlvxqs	1181	6	-	-	HYPH
cord-296347-fanlvxqs	1181	7	catalysed	catalyse	VBN
cord-296347-fanlvxqs	1181	8	intramembrane	intramembrane	NN
cord-296347-fanlvxqs	1181	9	proteolysis	proteolysis	NN
cord-296347-fanlvxqs	1181	10	;	;	:
cord-296347-fanlvxqs	1181	11	conformational	conformational	JJ
cord-296347-fanlvxqs	1181	12	control	control	NN
cord-296347-fanlvxqs	1181	13	of	of	IN
cord-296347-fanlvxqs	1181	14	peptide	peptide	JJ
cord-296347-fanlvxqs	1181	15	bond	bond	NN
cord-296347-fanlvxqs	1181	16	hydrolysis	hydrolysis	NN
cord-296347-fanlvxqs	1181	17	in	in	IN
cord-296347-fanlvxqs	1181	18	the	the	DT
cord-296347-fanlvxqs	1181	19	plane	plane	NN
cord-296347-fanlvxqs	1181	20	of	of	IN
cord-296347-fanlvxqs	1181	21	the	the	DT
cord-296347-fanlvxqs	1181	22	membrane	membrane	NN
cord-296347-fanlvxqs	1182	1	Intramembrane	Intramembrane	NNP
cord-296347-fanlvxqs	1182	2	proteolysis	proteolysis	NN
cord-296347-fanlvxqs	1182	3	of	of	IN
cord-296347-fanlvxqs	1182	4	signal	signal	NN
cord-296347-fanlvxqs	1182	5	peptides	peptide	NNS
cord-296347-fanlvxqs	1182	6	:	:	:
cord-296347-fanlvxqs	1182	7	An	an	DT
cord-296347-fanlvxqs	1182	8	essential	essential	JJ
cord-296347-fanlvxqs	1182	9	step	step	NN
cord-296347-fanlvxqs	1182	10	in	in	IN
cord-296347-fanlvxqs	1182	11	the	the	DT
cord-296347-fanlvxqs	1182	12	generation	generation	NN
cord-296347-fanlvxqs	1182	13	of	of	IN
cord-296347-fanlvxqs	1182	14	HLA	HLA	NNP
cord-296347-fanlvxqs	1182	15	-	-	HYPH
cord-296347-fanlvxqs	1182	16	E	E	NNP
cord-296347-fanlvxqs	1182	17	epitopes	epitopes	NNP
cord-296347-fanlvxqs	1182	18	Mechanism	Mechanism	NNP
cord-296347-fanlvxqs	1182	19	of	of	IN
cord-296347-fanlvxqs	1182	20	intramembrane	intramembrane	NNP
cord-296347-fanlvxqs	1182	21	proteolysis	proteolysis	NN
cord-296347-fanlvxqs	1182	22	investigated	investigate	VBN
cord-296347-fanlvxqs	1182	23	with	with	IN
cord-296347-fanlvxqs	1182	24	purified	purify	VBN
cord-296347-fanlvxqs	1182	25	rhomboid	rhomboid	NN
cord-296347-fanlvxqs	1182	26	proteases	protease	NNS
cord-296347-fanlvxqs	1182	27	Modulation	modulation	NN
cord-296347-fanlvxqs	1182	28	of	of	IN
cord-296347-fanlvxqs	1182	29	natural	natural	JJ
cord-296347-fanlvxqs	1182	30	killer	killer	NN
cord-296347-fanlvxqs	1182	31	cell	cell	NN
cord-296347-fanlvxqs	1182	32	cytotoxicity	cytotoxicity	NN
cord-296347-fanlvxqs	1182	33	in	in	IN
cord-296347-fanlvxqs	1182	34	human	human	JJ
cord-296347-fanlvxqs	1182	35	cytomegalovirus	cytomegalovirus	NN
cord-296347-fanlvxqs	1182	36	infection	infection	NN
cord-296347-fanlvxqs	1182	37	:	:	:
cord-296347-fanlvxqs	1182	38	The	the	DT
cord-296347-fanlvxqs	1182	39	role	role	NN
cord-296347-fanlvxqs	1182	40	of	of	IN
cord-296347-fanlvxqs	1182	41	endogenous	endogenous	JJ
cord-296347-fanlvxqs	1182	42	class	class	NN
cord-296347-fanlvxqs	1182	43	I	-PRON-	PRP
cord-296347-fanlvxqs	1182	44	major	major	JJ
cord-296347-fanlvxqs	1182	45	histocompatibility	histocompatibility	NN
cord-296347-fanlvxqs	1182	46	complex	complex	NN
cord-296347-fanlvxqs	1182	47	and	and	CC
cord-296347-fanlvxqs	1182	48	a	a	DT
cord-296347-fanlvxqs	1182	49	viral	viral	JJ
cord-296347-fanlvxqs	1182	50	class	class	NN
cord-296347-fanlvxqs	1183	1	I	-PRON-	PRP
cord-296347-fanlvxqs	1183	2	homolog	homolog	NN
cord-296347-fanlvxqs	1183	3	Inhibition	inhibition	NN
cord-296347-fanlvxqs	1183	4	of	of	IN
cord-296347-fanlvxqs	1183	5	antigen	antigen	NN
cord-296347-fanlvxqs	1183	6	processing	processing	NN
cord-296347-fanlvxqs	1183	7	by	by	IN
cord-296347-fanlvxqs	1183	8	the	the	DT
cord-296347-fanlvxqs	1183	9	internal	internal	JJ
cord-296347-fanlvxqs	1183	10	repeat	repeat	NN
cord-296347-fanlvxqs	1183	11	region	region	NN
cord-296347-fanlvxqs	1183	12	of	of	IN
cord-296347-fanlvxqs	1183	13	the	the	DT
cord-296347-fanlvxqs	1183	14	Epstein	Epstein	NNP
cord-296347-fanlvxqs	1183	15	-	-	HYPH
cord-296347-fanlvxqs	1183	16	Barr	Barr	NNP
cord-296347-fanlvxqs	1183	17	virus	virus	NN
cord-296347-fanlvxqs	1183	18	nuclear	nuclear	JJ
cord-296347-fanlvxqs	1183	19	antigen-1	antigen-1	NNP
cord-296347-fanlvxqs	1183	20	HIV-1	HIV-1	NNP
cord-296347-fanlvxqs	1183	21	assembly	assembly	NN
cord-296347-fanlvxqs	1183	22	and	and	CC
cord-296347-fanlvxqs	1183	23	budding	bud	VBG
cord-296347-fanlvxqs	1183	24	as	as	IN
cord-296347-fanlvxqs	1183	25	targets	target	NNS
cord-296347-fanlvxqs	1183	26	for	for	IN
cord-296347-fanlvxqs	1183	27	drug	drug	NN
cord-296347-fanlvxqs	1183	28	discovery	discovery	NN
cord-296347-fanlvxqs	1184	1	Multiple	multiple	JJ
cord-296347-fanlvxqs	1184	2	modes	mode	NNS
cord-296347-fanlvxqs	1184	3	of	of	IN
cord-296347-fanlvxqs	1184	4	interaction	interaction	NN
cord-296347-fanlvxqs	1184	5	of	of	IN
cord-296347-fanlvxqs	1184	6	the	the	DT
cord-296347-fanlvxqs	1184	7	deglycosylation	deglycosylation	NN
cord-296347-fanlvxqs	1184	8	enzyme	enzyme	NN
cord-296347-fanlvxqs	1184	9	,	,	,
cord-296347-fanlvxqs	1184	10	mouse	mouse	NN
cord-296347-fanlvxqs	1184	11	peptide	peptide	NN
cord-296347-fanlvxqs	1184	12	N	N	NNP
cord-296347-fanlvxqs	1184	13	-	-	HYPH
cord-296347-fanlvxqs	1184	14	glycanase	glycanase	NNP
cord-296347-fanlvxqs	1184	15	,	,	,
cord-296347-fanlvxqs	1184	16	with	with	IN
cord-296347-fanlvxqs	1184	17	the	the	DT
cord-296347-fanlvxqs	1184	18	proteasome	proteasome	NN
cord-296347-fanlvxqs	1185	1	The	the	DT
cord-296347-fanlvxqs	1185	2	AAA	AAA	NNP
cord-296347-fanlvxqs	1185	3	ATPase	ATPase	NNP
cord-296347-fanlvxqs	1185	4	p97	p97	CD
cord-296347-fanlvxqs	1185	5	links	link	NNS
cord-296347-fanlvxqs	1185	6	peptide	peptide	JJ
cord-296347-fanlvxqs	1185	7	N	N	NNP
cord-296347-fanlvxqs	1185	8	-	-	HYPH
cord-296347-fanlvxqs	1185	9	glycanase	glycanase	NN
cord-296347-fanlvxqs	1185	10	to	to	IN
cord-296347-fanlvxqs	1185	11	the	the	DT
cord-296347-fanlvxqs	1185	12	endoplasmic	endoplasmic	NN
cord-296347-fanlvxqs	1185	13	reticulum	reticulum	NN
cord-296347-fanlvxqs	1185	14	-	-	HYPH
cord-296347-fanlvxqs	1185	15	associated	associate	VBN
cord-296347-fanlvxqs	1185	16	E3	e3	NN
cord-296347-fanlvxqs	1185	17	ligase	ligase	NN
cord-296347-fanlvxqs	1186	1	autocrine	autocrine	JJ
cord-296347-fanlvxqs	1186	2	motility	motility	NN
cord-296347-fanlvxqs	1186	3	factor	factor	NN
cord-296347-fanlvxqs	1186	4	receptor	receptor	NN
cord-296347-fanlvxqs	1186	5	Epstein	Epstein	NNP
cord-296347-fanlvxqs	1186	6	-	-	HYPH
cord-296347-fanlvxqs	1186	7	Barr	Barr	NNP
cord-296347-fanlvxqs	1186	8	virus	virus	NN
cord-296347-fanlvxqs	1186	9	uses	use	VBZ
cord-296347-fanlvxqs	1186	10	HLA	HLA	NNP
cord-296347-fanlvxqs	1186	11	class	class	NN
cord-296347-fanlvxqs	1186	12	II	II	NNP
cord-296347-fanlvxqs	1186	13	as	as	IN
cord-296347-fanlvxqs	1186	14	a	a	DT
cord-296347-fanlvxqs	1186	15	cofactor	cofactor	NN
cord-296347-fanlvxqs	1186	16	for	for	IN
cord-296347-fanlvxqs	1186	17	infection	infection	NN
cord-296347-fanlvxqs	1186	18	of	of	IN
cord-296347-fanlvxqs	1186	19	B	b	NN
cord-296347-fanlvxqs	1186	20	lymphocytes	lymphocyte	NNS
cord-296347-fanlvxqs	1187	1	The	the	DT
cord-296347-fanlvxqs	1187	2	Ulp1	Ulp1	NNP
cord-296347-fanlvxqs	1187	3	SUMO	SUMO	NNP
cord-296347-fanlvxqs	1187	4	isopeptidase	isopeptidase	NN
cord-296347-fanlvxqs	1187	5	:	:	:
cord-296347-fanlvxqs	1188	1	Distinct	distinct	JJ
cord-296347-fanlvxqs	1188	2	domains	domain	NNS
cord-296347-fanlvxqs	1188	3	required	require	VBN
cord-296347-fanlvxqs	1188	4	for	for	IN
cord-296347-fanlvxqs	1188	5	viability	viability	NN
cord-296347-fanlvxqs	1188	6	,	,	,
cord-296347-fanlvxqs	1188	7	nuclear	nuclear	JJ
cord-296347-fanlvxqs	1188	8	envelope	envelope	NN
cord-296347-fanlvxqs	1188	9	localization	localization	NN
cord-296347-fanlvxqs	1188	10	,	,	,
cord-296347-fanlvxqs	1188	11	and	and	CC
cord-296347-fanlvxqs	1188	12	substrate	substrate	NN
cord-296347-fanlvxqs	1188	13	specificity	specificity	NN
cord-296347-fanlvxqs	1188	14	Structure	Structure	NNP
cord-296347-fanlvxqs	1188	15	of	of	IN
cord-296347-fanlvxqs	1188	16	DDB1	DDB1	NNP
cord-296347-fanlvxqs	1188	17	in	in	IN
cord-296347-fanlvxqs	1188	18	complex	complex	NN
cord-296347-fanlvxqs	1188	19	with	with	IN
cord-296347-fanlvxqs	1188	20	a	a	DT
cord-296347-fanlvxqs	1188	21	paramyxovirus	paramyxovirus	JJ
cord-296347-fanlvxqs	1188	22	V	v	NN
cord-296347-fanlvxqs	1188	23	protein	protein	NN
cord-296347-fanlvxqs	1188	24	:	:	:
cord-296347-fanlvxqs	1188	25	Viral	viral	JJ
cord-296347-fanlvxqs	1188	26	hijack	hijack	NN
cord-296347-fanlvxqs	1188	27	of	of	IN
cord-296347-fanlvxqs	1188	28	a	a	DT
cord-296347-fanlvxqs	1188	29	propeller	propeller	NN
cord-296347-fanlvxqs	1188	30	cluster	cluster	NN
cord-296347-fanlvxqs	1188	31	in	in	IN
cord-296347-fanlvxqs	1188	32	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1188	33	ligase	ligase	NN
cord-296347-fanlvxqs	1188	34	Overexpression	Overexpression	NNP
cord-296347-fanlvxqs	1188	35	of	of	IN
cord-296347-fanlvxqs	1188	36	the	the	DT
cord-296347-fanlvxqs	1188	37	tumor	tumor	NN
cord-296347-fanlvxqs	1189	1	autocrine	autocrine	JJ
cord-296347-fanlvxqs	1189	2	motility	motility	NN
cord-296347-fanlvxqs	1189	3	factor	factor	NN
cord-296347-fanlvxqs	1189	4	receptor	receptor	NN
cord-296347-fanlvxqs	1189	5	Gp78	gp78	NN
cord-296347-fanlvxqs	1189	6	,	,	,
cord-296347-fanlvxqs	1189	7	a	a	DT
cord-296347-fanlvxqs	1189	8	ubiquitin	ubiquitin	JJ
cord-296347-fanlvxqs	1189	9	protein	protein	NN
cord-296347-fanlvxqs	1189	10	ligase	ligase	NN
cord-296347-fanlvxqs	1189	11	,	,	,
cord-296347-fanlvxqs	1189	12	results	result	NNS
cord-296347-fanlvxqs	1189	13	in	in	IN
cord-296347-fanlvxqs	1189	14	increased	increase	VBN
cord-296347-fanlvxqs	1189	15	ubiquitinylation	ubiquitinylation	NN
cord-296347-fanlvxqs	1189	16	and	and	CC
cord-296347-fanlvxqs	1189	17	decreased	decrease	VBD
cord-296347-fanlvxqs	1189	18	secretion	secretion	NN
cord-296347-fanlvxqs	1189	19	of	of	IN
cord-296347-fanlvxqs	1189	20	apolipoprotein	apolipoprotein	NN
cord-296347-fanlvxqs	1189	21	B100	B100	NNS
cord-296347-fanlvxqs	1189	22	in	in	IN
cord-296347-fanlvxqs	1189	23	HepG2	HepG2	NNP
cord-296347-fanlvxqs	1189	24	cells	cell	NNS
cord-296347-fanlvxqs	1189	25	Overlapping	overlap	VBG
cord-296347-fanlvxqs	1189	26	motifs	motif	NNS
cord-296347-fanlvxqs	1189	27	(	(	-LRB-
cord-296347-fanlvxqs	1189	28	PTAP	PTAP	NNP
cord-296347-fanlvxqs	1189	29	and	and	CC
cord-296347-fanlvxqs	1189	30	PPEY	PPEY	NNP
cord-296347-fanlvxqs	1189	31	)	)	-RRB-
cord-296347-fanlvxqs	1189	32	within	within	IN
cord-296347-fanlvxqs	1189	33	the	the	DT
cord-296347-fanlvxqs	1189	34	Ebola	Ebola	NNP
cord-296347-fanlvxqs	1189	35	virus	virus	NN
cord-296347-fanlvxqs	1189	36	VP40	VP40	NNP
cord-296347-fanlvxqs	1189	37	protein	protein	NN
cord-296347-fanlvxqs	1189	38	function	function	VBP
cord-296347-fanlvxqs	1189	39	independently	independently	RB
cord-296347-fanlvxqs	1189	40	as	as	IN
cord-296347-fanlvxqs	1189	41	late	late	JJ
cord-296347-fanlvxqs	1189	42	budding	bud	VBG
cord-296347-fanlvxqs	1189	43	domains	domain	NNS
cord-296347-fanlvxqs	1189	44	:	:	:
cord-296347-fanlvxqs	1189	45	Involvement	involvement	NN
cord-296347-fanlvxqs	1189	46	of	of	IN
cord-296347-fanlvxqs	1189	47	host	host	NN
cord-296347-fanlvxqs	1189	48	proteins	protein	NNS
cord-296347-fanlvxqs	1189	49	TSG101	TSG101	NNP
cord-296347-fanlvxqs	1189	50	and	and	CC
cord-296347-fanlvxqs	1189	51	VPS-4	VPS-4	NNP
cord-296347-fanlvxqs	1190	1	A	a	DT
cord-296347-fanlvxqs	1190	2	membrane	membrane	NN
cord-296347-fanlvxqs	1190	3	protein	protein	NN
cord-296347-fanlvxqs	1190	4	required	require	VBN
cord-296347-fanlvxqs	1190	5	for	for	IN
cord-296347-fanlvxqs	1190	6	dislocation	dislocation	NN
cord-296347-fanlvxqs	1190	7	of	of	IN
cord-296347-fanlvxqs	1190	8	misfolded	misfolded	JJ
cord-296347-fanlvxqs	1190	9	proteins	protein	NNS
cord-296347-fanlvxqs	1190	10	from	from	IN
cord-296347-fanlvxqs	1190	11	the	the	DT
cord-296347-fanlvxqs	1190	12	ER	ER	NNP
cord-296347-fanlvxqs	1190	13	Multiprotein	Multiprotein	NNP
cord-296347-fanlvxqs	1190	14	complexes	complex	NNS
cord-296347-fanlvxqs	1190	15	that	that	WDT
cord-296347-fanlvxqs	1190	16	link	link	VBP
cord-296347-fanlvxqs	1190	17	dislocation	dislocation	NN
cord-296347-fanlvxqs	1190	18	,	,	,
cord-296347-fanlvxqs	1190	19	ubiquitination	ubiquitination	NN
cord-296347-fanlvxqs	1190	20	,	,	,
cord-296347-fanlvxqs	1190	21	and	and	CC
cord-296347-fanlvxqs	1190	22	extraction	extraction	NN
cord-296347-fanlvxqs	1190	23	of	of	IN
cord-296347-fanlvxqs	1190	24	misfolded	misfolded	JJ
cord-296347-fanlvxqs	1190	25	proteins	protein	NNS
cord-296347-fanlvxqs	1190	26	from	from	IN
cord-296347-fanlvxqs	1190	27	the	the	DT
cord-296347-fanlvxqs	1190	28	endoplasmic	endoplasmic	NN
cord-296347-fanlvxqs	1190	29	reticulum	reticulum	NN
cord-296347-fanlvxqs	1190	30	membrane	membrane	NN
cord-296347-fanlvxqs	1190	31	Viral	viral	JJ
cord-296347-fanlvxqs	1190	32	modulation	modulation	NN
cord-296347-fanlvxqs	1190	33	of	of	IN
cord-296347-fanlvxqs	1190	34	antigen	antigen	NN
cord-296347-fanlvxqs	1190	35	presentation	presentation	NN
cord-296347-fanlvxqs	1190	36	:	:	:
cord-296347-fanlvxqs	1190	37	Manipulation	manipulation	NN
cord-296347-fanlvxqs	1190	38	of	of	IN
cord-296347-fanlvxqs	1190	39	cellular	cellular	JJ
cord-296347-fanlvxqs	1190	40	targets	target	NNS
cord-296347-fanlvxqs	1190	41	in	in	IN
cord-296347-fanlvxqs	1190	42	the	the	DT
cord-296347-fanlvxqs	1190	43	ER	ER	NNP
cord-296347-fanlvxqs	1190	44	and	and	CC
cord-296347-fanlvxqs	1190	45	beyond	beyond	IN
cord-296347-fanlvxqs	1190	46	Dislocation	dislocation	NN
cord-296347-fanlvxqs	1190	47	of	of	IN
cord-296347-fanlvxqs	1190	48	a	a	DT
cord-296347-fanlvxqs	1190	49	type	type	NN
cord-296347-fanlvxqs	1190	50	I	-PRON-	PRP
cord-296347-fanlvxqs	1190	51	membrane	membrane	NN
cord-296347-fanlvxqs	1190	52	protein	protein	NN
cord-296347-fanlvxqs	1190	53	requires	require	VBZ
cord-296347-fanlvxqs	1190	54	interactions	interaction	NNS
cord-296347-fanlvxqs	1190	55	between	between	IN
cord-296347-fanlvxqs	1190	56	membrane	membrane	NN
cord-296347-fanlvxqs	1190	57	-	-	HYPH
cord-296347-fanlvxqs	1190	58	spanning	span	VBG
cord-296347-fanlvxqs	1190	59	segments	segment	NNS
cord-296347-fanlvxqs	1190	60	within	within	IN
cord-296347-fanlvxqs	1190	61	the	the	DT
cord-296347-fanlvxqs	1190	62	lipid	lipid	NN
cord-296347-fanlvxqs	1190	63	bilayer	bilayer	NN
cord-296347-fanlvxqs	1190	64	Hepatitis	Hepatitis	NNP
cord-296347-fanlvxqs	1190	65	C	C	NNP
cord-296347-fanlvxqs	1190	66	virus	virus	NN
cord-296347-fanlvxqs	1190	67	expression	expression	NN
cord-296347-fanlvxqs	1190	68	suppresses	suppress	VBZ
cord-296347-fanlvxqs	1190	69	interferon	interferon	NN
cord-296347-fanlvxqs	1190	70	signaling	signal	VBG
cord-296347-fanlvxqs	1190	71	by	by	IN
cord-296347-fanlvxqs	1190	72	degrading	degrade	VBG
cord-296347-fanlvxqs	1190	73	STAT1	stat1	XX
cord-296347-fanlvxqs	1191	1	The	the	DT
cord-296347-fanlvxqs	1191	2	papain	papain	NN
cord-296347-fanlvxqs	1191	3	-	-	HYPH
cord-296347-fanlvxqs	1191	4	like	like	JJ
cord-296347-fanlvxqs	1191	5	protease	protease	NN
cord-296347-fanlvxqs	1191	6	from	from	IN
cord-296347-fanlvxqs	1191	7	the	the	DT
cord-296347-fanlvxqs	1191	8	severe	severe	JJ
cord-296347-fanlvxqs	1191	9	acute	acute	JJ
cord-296347-fanlvxqs	1191	10	respiratory	respiratory	JJ
cord-296347-fanlvxqs	1191	11	syndrome	syndrome	NN
cord-296347-fanlvxqs	1191	12	coronavirus	coronavirus	NN
cord-296347-fanlvxqs	1191	13	is	be	VBZ
cord-296347-fanlvxqs	1191	14	a	a	DT
cord-296347-fanlvxqs	1191	15	deubiquitinating	deubiquitinating	NN
cord-296347-fanlvxqs	1191	16	enzyme	enzyme	NN
cord-296347-fanlvxqs	1191	17	Ubiquitin	Ubiquitin	NNP
cord-296347-fanlvxqs	1191	18	ligases	ligase	NNS
cord-296347-fanlvxqs	1191	19	and	and	CC
cord-296347-fanlvxqs	1191	20	the	the	DT
cord-296347-fanlvxqs	1191	21	immune	immune	JJ
cord-296347-fanlvxqs	1191	22	response	response	NN
cord-296347-fanlvxqs	1191	23	Immunity	immunity	NN
cord-296347-fanlvxqs	1191	24	by	by	IN
cord-296347-fanlvxqs	1191	25	ubiquitylation	ubiquitylation	NN
cord-296347-fanlvxqs	1191	26	:	:	:
cord-296347-fanlvxqs	1191	27	A	a	DT
cord-296347-fanlvxqs	1191	28	reversible	reversible	JJ
cord-296347-fanlvxqs	1191	29	process	process	NN
cord-296347-fanlvxqs	1191	30	of	of	IN
cord-296347-fanlvxqs	1191	31	modification	modification	NN
cord-296347-fanlvxqs	1191	32	Viral	viral	JJ
cord-296347-fanlvxqs	1191	33	modulation	modulation	NN
cord-296347-fanlvxqs	1191	34	of	of	IN
cord-296347-fanlvxqs	1191	35	NK	NK	NNP
cord-296347-fanlvxqs	1191	36	cell	cell	NN
cord-296347-fanlvxqs	1191	37	immunity	immunity	NN
cord-296347-fanlvxqs	1191	38	ER	ER	NNP
cord-296347-fanlvxqs	1191	39	dislocation	dislocation	NN
cord-296347-fanlvxqs	1191	40	:	:	:
cord-296347-fanlvxqs	1191	41	Cdc48p	Cdc48p	NNP
cord-296347-fanlvxqs	1191	42	/	/	SYM
cord-296347-fanlvxqs	1191	43	p97	p97	CD
cord-296347-fanlvxqs	1191	44	gets	get	VBZ
cord-296347-fanlvxqs	1191	45	into	into	IN
cord-296347-fanlvxqs	1191	46	the	the	DT
cord-296347-fanlvxqs	1191	47	AAAct	AAAct	NNP
cord-296347-fanlvxqs	1191	48	Signal	Signal	NNP
cord-296347-fanlvxqs	1191	49	peptide	peptide	NN
cord-296347-fanlvxqs	1191	50	peptidase	peptidase	NN
cord-296347-fanlvxqs	1191	51	is	be	VBZ
cord-296347-fanlvxqs	1191	52	required	require	VBN
cord-296347-fanlvxqs	1191	53	for	for	IN
cord-296347-fanlvxqs	1191	54	dislocation	dislocation	NN
cord-296347-fanlvxqs	1191	55	from	from	IN
cord-296347-fanlvxqs	1191	56	the	the	DT
cord-296347-fanlvxqs	1191	57	endoplasmic	endoplasmic	NN
cord-296347-fanlvxqs	1191	58	reticulum	reticulum	NN
cord-296347-fanlvxqs	1191	59	Primate	Primate	NNP
cord-296347-fanlvxqs	1191	60	lentiviral	lentiviral	JJ
cord-296347-fanlvxqs	1191	61	virion	virion	NN
cord-296347-fanlvxqs	1191	62	infectivity	infectivity	NN
cord-296347-fanlvxqs	1191	63	factors	factor	NNS
cord-296347-fanlvxqs	1192	1	are	be	VBP
cord-296347-fanlvxqs	1192	2	substrate	substrate	JJ
cord-296347-fanlvxqs	1192	3	receptors	receptor	NNS
cord-296347-fanlvxqs	1192	4	that	that	WDT
cord-296347-fanlvxqs	1192	5	assemble	assemble	VBP
cord-296347-fanlvxqs	1192	6	with	with	IN
cord-296347-fanlvxqs	1192	7	cullin	cullin	NNP
cord-296347-fanlvxqs	1192	8	5-E3	5-e3	CD
cord-296347-fanlvxqs	1192	9	ligase	ligase	NN
cord-296347-fanlvxqs	1192	10	through	through	IN
cord-296347-fanlvxqs	1192	11	a	a	DT
cord-296347-fanlvxqs	1192	12	HCCH	HCCH	NNS
cord-296347-fanlvxqs	1192	13	motif	motif	NN
cord-296347-fanlvxqs	1192	14	to	to	TO
cord-296347-fanlvxqs	1192	15	suppress	suppress	VB
cord-296347-fanlvxqs	1192	16	APOBEC3	apobec3	DT
cord-296347-fanlvxqs	1192	17	G	g	NN
cord-296347-fanlvxqs	1192	18	Viral	viral	JJ
cord-296347-fanlvxqs	1192	19	immune	immune	JJ
cord-296347-fanlvxqs	1192	20	evasion	evasion	NN
cord-296347-fanlvxqs	1192	21	molecules	molecule	NNS
cord-296347-fanlvxqs	1192	22	attack	attack	VBP
cord-296347-fanlvxqs	1192	23	the	the	DT
cord-296347-fanlvxqs	1192	24	ER	ER	NNP
cord-296347-fanlvxqs	1192	25	peptide	peptide	NN
cord-296347-fanlvxqs	1192	26	-	-	HYPH
cord-296347-fanlvxqs	1192	27	loading	load	VBG
cord-296347-fanlvxqs	1192	28	complex	complex	NN
cord-296347-fanlvxqs	1192	29	and	and	CC
cord-296347-fanlvxqs	1192	30	exploit	exploit	VB
cord-296347-fanlvxqs	1192	31	ER	ER	NNP
cord-296347-fanlvxqs	1192	32	-	-	HYPH
cord-296347-fanlvxqs	1192	33	associated	associate	VBN
cord-296347-fanlvxqs	1192	34	degradation	degradation	NN
cord-296347-fanlvxqs	1192	35	pathways	pathway	NNS
cord-296347-fanlvxqs	1192	36	Virus	Virus	NNP
cord-296347-fanlvxqs	1192	37	subversion	subversion	NN
cord-296347-fanlvxqs	1192	38	of	of	IN
cord-296347-fanlvxqs	1192	39	the	the	DT
cord-296347-fanlvxqs	1192	40	MHC	MHC	NNP
cord-296347-fanlvxqs	1192	41	class	class	NN
cord-296347-fanlvxqs	1192	42	I	i	NN
cord-296347-fanlvxqs	1192	43	peptide	peptide	NN
cord-296347-fanlvxqs	1192	44	-	-	HYPH
cord-296347-fanlvxqs	1192	45	loading	load	VBG
cord-296347-fanlvxqs	1192	46	complex	complex	NN
cord-296347-fanlvxqs	1193	1	The	the	DT
cord-296347-fanlvxqs	1193	2	HCMV	HCMV	NNP
cord-296347-fanlvxqs	1193	3	gene	gene	NN
cord-296347-fanlvxqs	1193	4	products	product	NNS
cord-296347-fanlvxqs	1193	5	US11	US11	NNP
cord-296347-fanlvxqs	1193	6	and	and	CC
cord-296347-fanlvxqs	1193	7	US2	US2	NNP
cord-296347-fanlvxqs	1193	8	differ	differ	VBP
cord-296347-fanlvxqs	1193	9	in	in	IN
cord-296347-fanlvxqs	1193	10	their	-PRON-	PRP$
cord-296347-fanlvxqs	1193	11	ability	ability	NN
cord-296347-fanlvxqs	1193	12	to	to	TO
cord-296347-fanlvxqs	1193	13	attack	attack	VB
cord-296347-fanlvxqs	1193	14	allelic	allelic	JJ
cord-296347-fanlvxqs	1193	15	forms	form	NNS
cord-296347-fanlvxqs	1193	16	of	of	IN
cord-296347-fanlvxqs	1193	17	murine	murine	JJ
cord-296347-fanlvxqs	1193	18	major	major	JJ
cord-296347-fanlvxqs	1193	19	histocompatibility	histocompatibility	NN
cord-296347-fanlvxqs	1193	20	complex	complex	NN
cord-296347-fanlvxqs	1193	21	(	(	-LRB-
cord-296347-fanlvxqs	1193	22	MHC	MHC	NNP
cord-296347-fanlvxqs	1193	23	)	)	-RRB-
cord-296347-fanlvxqs	1193	24	class	class	NN
cord-296347-fanlvxqs	1194	1	I	-PRON-	PRP
cord-296347-fanlvxqs	1194	2	heavy	heavy	JJ
cord-296347-fanlvxqs	1194	3	chains	chain	NNS
cord-296347-fanlvxqs	1195	1	High	high	JJ
cord-296347-fanlvxqs	1195	2	-	-	HYPH
cord-296347-fanlvxqs	1195	3	throughput	throughput	NN
cord-296347-fanlvxqs	1195	4	immunoblotting	immunoblotting	NN
cord-296347-fanlvxqs	1195	5	.	.	.
cord-296347-fanlvxqs	1196	1	Ubiquitiin	Ubiquitiin	NNP
cord-296347-fanlvxqs	1196	2	-	-	HYPH
cord-296347-fanlvxqs	1196	3	like	like	JJ
cord-296347-fanlvxqs	1196	4	protein	protein	NN
cord-296347-fanlvxqs	1197	1	ISG15	ISG15	NNP
cord-296347-fanlvxqs	1197	2	modifies	modify	VBZ
cord-296347-fanlvxqs	1197	3	key	key	JJ
cord-296347-fanlvxqs	1197	4	regulators	regulator	NNS
cord-296347-fanlvxqs	1197	5	of	of	IN
cord-296347-fanlvxqs	1197	6	signal	signal	NN
cord-296347-fanlvxqs	1197	7	transduction	transduction	NN
cord-296347-fanlvxqs	1197	8	UBP43	UBP43	NNP
cord-296347-fanlvxqs	1197	9	(	(	-LRB-
cord-296347-fanlvxqs	1197	10	USP18	usp18	JJ
cord-296347-fanlvxqs	1197	11	)	)	-RRB-
cord-296347-fanlvxqs	1197	12	specifically	specifically	RB
cord-296347-fanlvxqs	1197	13	removes	remove	VBZ
cord-296347-fanlvxqs	1197	14	ISG15	isg15	NN
cord-296347-fanlvxqs	1197	15	from	from	IN
cord-296347-fanlvxqs	1197	16	conjugated	conjugated	JJ
cord-296347-fanlvxqs	1197	17	proteins	protein	NNS
cord-296347-fanlvxqs	1197	18	UBP43	UBP43	NNP
cord-296347-fanlvxqs	1198	1	is	be	VBZ
cord-296347-fanlvxqs	1198	2	a	a	DT
cord-296347-fanlvxqs	1198	3	novel	novel	JJ
cord-296347-fanlvxqs	1198	4	regulator	regulator	NN
cord-296347-fanlvxqs	1198	5	of	of	IN
cord-296347-fanlvxqs	1198	6	interferon	interferon	NN
cord-296347-fanlvxqs	1198	7	signaling	signal	VBG
cord-296347-fanlvxqs	1198	8	independent	independent	JJ
cord-296347-fanlvxqs	1198	9	of	of	IN
cord-296347-fanlvxqs	1198	10	its	-PRON-	PRP$
cord-296347-fanlvxqs	1198	11	ISG15	ISG15	NNP
cord-296347-fanlvxqs	1198	12	isopeptidase	isopeptidase	IN
cord-296347-fanlvxqs	1198	13	activity	activity	NN
cord-296347-fanlvxqs	1199	1	Negative	negative	JJ
cord-296347-fanlvxqs	1199	2	factor	factor	NN
cord-296347-fanlvxqs	1199	3	from	from	IN
cord-296347-fanlvxqs	1199	4	SIV	SIV	NNP
cord-296347-fanlvxqs	1199	5	binds	bind	VBZ
cord-296347-fanlvxqs	1199	6	to	to	IN
cord-296347-fanlvxqs	1199	7	the	the	DT
cord-296347-fanlvxqs	1199	8	catalytic	catalytic	JJ
cord-296347-fanlvxqs	1199	9	subunit	subunit	NN
cord-296347-fanlvxqs	1199	10	of	of	IN
cord-296347-fanlvxqs	1199	11	the	the	DT
cord-296347-fanlvxqs	1199	12	V	V	NNP
cord-296347-fanlvxqs	1199	13	-	-	HYPH
cord-296347-fanlvxqs	1199	14	ATPase	ATPase	NNP
cord-296347-fanlvxqs	1199	15	to	to	TO
cord-296347-fanlvxqs	1199	16	internalize	internalize	VB
cord-296347-fanlvxqs	1199	17	CD4	CD4	NNP
cord-296347-fanlvxqs	1199	18	and	and	CC
cord-296347-fanlvxqs	1199	19	to	to	TO
cord-296347-fanlvxqs	1199	20	increase	increase	VB
cord-296347-fanlvxqs	1199	21	viral	viral	JJ
cord-296347-fanlvxqs	1199	22	infectivity	infectivity	NN
cord-296347-fanlvxqs	1200	1	The	the	DT
cord-296347-fanlvxqs	1200	2	multifaceted	multifaceted	JJ
cord-296347-fanlvxqs	1200	3	role	role	NN
cord-296347-fanlvxqs	1200	4	of	of	IN
cord-296347-fanlvxqs	1200	5	HIV	HIV	NNP
cord-296347-fanlvxqs	1200	6	Nef	Nef	NNP
cord-296347-fanlvxqs	1200	7	Nef	Nef	NNP
cord-296347-fanlvxqs	1200	8	-	-	HYPH
cord-296347-fanlvxqs	1200	9	induced	induce	VBN
cord-296347-fanlvxqs	1200	10	CD4	CD4	NNP
cord-296347-fanlvxqs	1200	11	and	and	CC
cord-296347-fanlvxqs	1200	12	major	major	JJ
cord-296347-fanlvxqs	1200	13	histocompatibility	histocompatibility	NN
cord-296347-fanlvxqs	1200	14	complex	complex	NN
cord-296347-fanlvxqs	1200	15	class	class	NN
cord-296347-fanlvxqs	1201	1	I	-PRON-	PRP
cord-296347-fanlvxqs	1202	1	(	(	-LRB-
cord-296347-fanlvxqs	1202	2	MHC	MHC	NNP
cord-296347-fanlvxqs	1202	3	-	-	HYPH
cord-296347-fanlvxqs	1202	4	I	I	NNP
cord-296347-fanlvxqs	1202	5	)	)	-RRB-
cord-296347-fanlvxqs	1202	6	down	down	IN
cord-296347-fanlvxqs	1202	7	-	-	HYPH
cord-296347-fanlvxqs	1202	8	regulation	regulation	NN
cord-296347-fanlvxqs	1202	9	are	be	VBP
cord-296347-fanlvxqs	1202	10	governed	govern	VBN
cord-296347-fanlvxqs	1202	11	by	by	IN
cord-296347-fanlvxqs	1202	12	distinct	distinct	JJ
cord-296347-fanlvxqs	1202	13	determinants	determinant	NNS
cord-296347-fanlvxqs	1202	14	:	:	:
cord-296347-fanlvxqs	1202	15	N	n	CD
cord-296347-fanlvxqs	1202	16	-	-	HYPH
cord-296347-fanlvxqs	1202	17	terminal	terminal	JJ
cord-296347-fanlvxqs	1202	18	alpha	alpha	NN
cord-296347-fanlvxqs	1202	19	helix	helix	NN
cord-296347-fanlvxqs	1202	20	and	and	CC
cord-296347-fanlvxqs	1202	21	proline	proline	NN
cord-296347-fanlvxqs	1202	22	repeat	repeat	NN
cord-296347-fanlvxqs	1202	23	of	of	IN
cord-296347-fanlvxqs	1202	24	Nef	Nef	NNP
cord-296347-fanlvxqs	1202	25	selectively	selectively	RB
cord-296347-fanlvxqs	1202	26	regulate	regulate	VBP
cord-296347-fanlvxqs	1202	27	MHC-	MHC-	NNP
cord-296347-fanlvxqs	1203	1	I	-PRON-	PRP
cord-296347-fanlvxqs	1203	2	trafficking	traffic	VBG
cord-296347-fanlvxqs	1203	3	The	the	DT
cord-296347-fanlvxqs	1203	4	PHD	PHD	NNP
cord-296347-fanlvxqs	1203	5	/	/	SYM
cord-296347-fanlvxqs	1203	6	LAP	lap	NN
cord-296347-fanlvxqs	1203	7	-	-	HYPH
cord-296347-fanlvxqs	1203	8	domain	domain	NN
cord-296347-fanlvxqs	1203	9	protein	protein	NN
cord-296347-fanlvxqs	1203	10	M153R	m153r	NN
cord-296347-fanlvxqs	1203	11	of	of	IN
cord-296347-fanlvxqs	1203	12	myxomavirus	myxomavirus	NNP
cord-296347-fanlvxqs	1203	13	is	be	VBZ
cord-296347-fanlvxqs	1203	14	a	a	DT
cord-296347-fanlvxqs	1203	15	ubiquitin	ubiquitin	JJ
cord-296347-fanlvxqs	1203	16	ligase	ligase	NN
cord-296347-fanlvxqs	1203	17	that	that	WDT
cord-296347-fanlvxqs	1203	18	induces	induce	VBZ
cord-296347-fanlvxqs	1203	19	the	the	DT
cord-296347-fanlvxqs	1203	20	rapid	rapid	JJ
cord-296347-fanlvxqs	1203	21	internalization	internalization	NN
cord-296347-fanlvxqs	1203	22	and	and	CC
cord-296347-fanlvxqs	1203	23	lysosomal	lysosomal	JJ
cord-296347-fanlvxqs	1203	24	destruction	destruction	NN
cord-296347-fanlvxqs	1203	25	of	of	IN
cord-296347-fanlvxqs	1203	26	CD4	CD4	NNP
cord-296347-fanlvxqs	1203	27	A	a	DT
cord-296347-fanlvxqs	1203	28	novel	novel	JJ
cord-296347-fanlvxqs	1203	29	human	human	NN
cord-296347-fanlvxqs	1203	30	WD	WD	NNP
cord-296347-fanlvxqs	1203	31	protein	protein	NN
cord-296347-fanlvxqs	1203	32	,	,	,
cord-296347-fanlvxqs	1203	33	h	h	NN
cord-296347-fanlvxqs	1203	34	-	-	HYPH
cord-296347-fanlvxqs	1203	35	beta	beta	NN
cord-296347-fanlvxqs	1203	36	TrCp	TrCp	NNP
cord-296347-fanlvxqs	1203	37	Vpu	Vpu	NNP
cord-296347-fanlvxqs	1203	38	connects	connect	VBZ
cord-296347-fanlvxqs	1203	39	CD4	CD4	NNP
cord-296347-fanlvxqs	1203	40	to	to	IN
cord-296347-fanlvxqs	1203	41	the	the	DT
cord-296347-fanlvxqs	1203	42	ER	ER	NNP
cord-296347-fanlvxqs	1203	43	degradation	degradation	NN
cord-296347-fanlvxqs	1203	44	pathway	pathway	NN
cord-296347-fanlvxqs	1203	45	through	through	IN
cord-296347-fanlvxqs	1203	46	an	an	DT
cord-296347-fanlvxqs	1203	47	F	F	NNP
cord-296347-fanlvxqs	1203	48	-	-	HYPH
cord-296347-fanlvxqs	1203	49	box	box	NN
cord-296347-fanlvxqs	1203	50	motif	motif	NN
cord-296347-fanlvxqs	1203	51	Virus	virus	NN
cord-296347-fanlvxqs	1203	52	entry	entry	NN
cord-296347-fanlvxqs	1203	53	:	:	:
cord-296347-fanlvxqs	1203	54	Open	open	VB
cord-296347-fanlvxqs	1203	55	sesame	sesame	NN
cord-296347-fanlvxqs	1203	56	Role	role	NN
cord-296347-fanlvxqs	1203	57	of	of	IN
cord-296347-fanlvxqs	1203	58	ESCRT	ESCRT	NNP
cord-296347-fanlvxqs	1203	59	-	-	:
cord-296347-fanlvxqs	1203	60	I	-PRON-	PRP
cord-296347-fanlvxqs	1203	61	in	in	IN
cord-296347-fanlvxqs	1203	62	retroviral	retroviral	NN
cord-296347-fanlvxqs	1203	63	budding	bud	VBG
cord-296347-fanlvxqs	1203	64	Intramembrane	Intramembrane	NNP
cord-296347-fanlvxqs	1203	65	proteolysis	proteolysis	NN
cord-296347-fanlvxqs	1203	66	and	and	CC
cord-296347-fanlvxqs	1203	67	post	post	NN
cord-296347-fanlvxqs	1203	68	-	-	JJ
cord-296347-fanlvxqs	1203	69	targeting	targeting	JJ
cord-296347-fanlvxqs	1203	70	functions	function	NNS
cord-296347-fanlvxqs	1203	71	of	of	IN
cord-296347-fanlvxqs	1203	72	signal	signal	NN
cord-296347-fanlvxqs	1203	73	peptides	peptide	NNS
cord-296347-fanlvxqs	1203	74	Intramembrane	Intramembrane	NNP
cord-296347-fanlvxqs	1203	75	-	-	HYPH
cord-296347-fanlvxqs	1203	76	cleaving	cleave	VBG
cord-296347-fanlvxqs	1203	77	aspartic	aspartic	JJ
cord-296347-fanlvxqs	1203	78	proteases	protease	NNS
cord-296347-fanlvxqs	1203	79	and	and	CC
cord-296347-fanlvxqs	1203	80	disease	disease	NN
cord-296347-fanlvxqs	1203	81	:	:	:
cord-296347-fanlvxqs	1203	82	Presenilins	Presenilins	NNP
cord-296347-fanlvxqs	1203	83	,	,	,
cord-296347-fanlvxqs	1203	84	signal	signal	NN
cord-296347-fanlvxqs	1203	85	peptide	peptide	NN
cord-296347-fanlvxqs	1203	86	peptidase	peptidase	NN
cord-296347-fanlvxqs	1203	87	and	and	CC
cord-296347-fanlvxqs	1203	88	their	-PRON-	PRP$
cord-296347-fanlvxqs	1203	89	homologs	homolog	NNS
cord-296347-fanlvxqs	1203	90	Signal	Signal	NNP
cord-296347-fanlvxqs	1203	91	peptide	peptide	NN
cord-296347-fanlvxqs	1203	92	fragments	fragment	NNS
cord-296347-fanlvxqs	1203	93	of	of	IN
cord-296347-fanlvxqs	1203	94	preprolactin	preprolactin	NNS
cord-296347-fanlvxqs	1203	95	and	and	CC
cord-296347-fanlvxqs	1203	96	HIV-1	HIV-1	NNP
cord-296347-fanlvxqs	1203	97	p	p	NNP
cord-296347-fanlvxqs	1203	98	-	-	HYPH
cord-296347-fanlvxqs	1203	99	gp160	gp160	NNP
cord-296347-fanlvxqs	1204	1	interact	interact	VB
cord-296347-fanlvxqs	1204	2	with	with	IN
cord-296347-fanlvxqs	1204	3	calmodulin	calmodulin	NNP
cord-296347-fanlvxqs	1204	4	New	new	JJ
cord-296347-fanlvxqs	1204	5	lessons	lesson	NNS
cord-296347-fanlvxqs	1204	6	from	from	IN
cord-296347-fanlvxqs	1204	7	old	old	JJ
cord-296347-fanlvxqs	1204	8	pathogens	pathogen	NNS
cord-296347-fanlvxqs	1205	1	:	:	:
cord-296347-fanlvxqs	1205	2	What	what	WDT
cord-296347-fanlvxqs	1205	3	parasitic	parasitic	JJ
cord-296347-fanlvxqs	1205	4	infections	infection	NNS
cord-296347-fanlvxqs	1205	5	have	have	VBP
cord-296347-fanlvxqs	1205	6	taught	teach	VBN
cord-296347-fanlvxqs	1205	7	us	-PRON-	PRP
cord-296347-fanlvxqs	1205	8	about	about	IN
cord-296347-fanlvxqs	1205	9	the	the	DT
cord-296347-fanlvxqs	1205	10	role	role	NN
cord-296347-fanlvxqs	1205	11	of	of	IN
cord-296347-fanlvxqs	1205	12	nuclear	nuclear	JJ
cord-296347-fanlvxqs	1205	13	factor	factor	NN
cord-296347-fanlvxqs	1205	14	-	-	:
cord-296347-fanlvxqs	1205	15	kappaB	kappaB	NNP
cord-296347-fanlvxqs	1205	16	in	in	IN
cord-296347-fanlvxqs	1205	17	the	the	DT
cord-296347-fanlvxqs	1205	18	regulation	regulation	NN
cord-296347-fanlvxqs	1205	19	of	of	IN
cord-296347-fanlvxqs	1205	20	immunity	immunity	NN
cord-296347-fanlvxqs	1206	1	Intramembrane	Intramembrane	NNP
cord-296347-fanlvxqs	1206	2	proteolysis	proteolysis	NN
cord-296347-fanlvxqs	1206	3	promotes	promote	VBZ
cord-296347-fanlvxqs	1206	4	trafficking	trafficking	NN
cord-296347-fanlvxqs	1206	5	of	of	IN
cord-296347-fanlvxqs	1206	6	hepatitis	hepatitis	NN
cord-296347-fanlvxqs	1206	7	C	C	NNP
cord-296347-fanlvxqs	1206	8	virus	virus	NN
cord-296347-fanlvxqs	1206	9	core	core	NN
cord-296347-fanlvxqs	1206	10	protein	protein	NN
cord-296347-fanlvxqs	1206	11	to	to	IN
cord-296347-fanlvxqs	1206	12	lipid	lipid	NN
cord-296347-fanlvxqs	1206	13	droplets	droplet	NNS
cord-296347-fanlvxqs	1206	14	COP	cop	NN
cord-296347-fanlvxqs	1206	15	and	and	CC
cord-296347-fanlvxqs	1206	16	clathrin	clathrin	NN
cord-296347-fanlvxqs	1206	17	-	-	HYPH
cord-296347-fanlvxqs	1206	18	coated	coat	VBN
cord-296347-fanlvxqs	1206	19	vesicle	vesicle	NN
cord-296347-fanlvxqs	1206	20	budding	budding	NN
cord-296347-fanlvxqs	1206	21	:	:	:
cord-296347-fanlvxqs	1207	1	Different	different	JJ
cord-296347-fanlvxqs	1207	2	pathways	pathway	NNS
cord-296347-fanlvxqs	1207	3	,	,	,
cord-296347-fanlvxqs	1207	4	common	common	JJ
cord-296347-fanlvxqs	1207	5	approaches	approach	NNS
cord-296347-fanlvxqs	1208	1	The	the	DT
cord-296347-fanlvxqs	1208	2	Hsc70	Hsc70	NNP
cord-296347-fanlvxqs	1208	3	co	co	NN
cord-296347-fanlvxqs	1208	4	-	-	JJ
cord-296347-fanlvxqs	1208	5	chaperone	chaperone	JJ
cord-296347-fanlvxqs	1208	6	CHIP	chip	NN
cord-296347-fanlvxqs	1208	7	targets	target	NNS
cord-296347-fanlvxqs	1208	8	immature	immature	JJ
cord-296347-fanlvxqs	1208	9	CFTR	CFTR	NNP
cord-296347-fanlvxqs	1208	10	for	for	IN
cord-296347-fanlvxqs	1208	11	proteasomal	proteasomal	JJ
cord-296347-fanlvxqs	1208	12	degradation	degradation	NN
cord-296347-fanlvxqs	1209	1	A	a	DT
cord-296347-fanlvxqs	1209	2	genomic	genomic	JJ
cord-296347-fanlvxqs	1209	3	screen	screen	NN
cord-296347-fanlvxqs	1209	4	identifies	identify	VBZ
cord-296347-fanlvxqs	1209	5	Dsk2p	Dsk2p	NNP
cord-296347-fanlvxqs	1209	6	and	and	CC
cord-296347-fanlvxqs	1209	7	Rad23p	Rad23p	NNP
cord-296347-fanlvxqs	1209	8	as	as	IN
cord-296347-fanlvxqs	1209	9	essential	essential	JJ
cord-296347-fanlvxqs	1209	10	components	component	NNS
cord-296347-fanlvxqs	1209	11	of	of	IN
cord-296347-fanlvxqs	1209	12	ER	ER	NNP
cord-296347-fanlvxqs	1209	13	-	-	HYPH
cord-296347-fanlvxqs	1209	14	associated	associate	VBN
cord-296347-fanlvxqs	1209	15	degradation	degradation	NN
cord-296347-fanlvxqs	1209	16	CD85/	cd85/	NN
cord-296347-fanlvxqs	1210	1	LIR-1/	LIR-1/	NNP
cord-296347-fanlvxqs	1210	2	ILT2	ILT2	NNP
cord-296347-fanlvxqs	1210	3	and	and	CC
cord-296347-fanlvxqs	1210	4	CD152	CD152	NNP
cord-296347-fanlvxqs	1210	5	(	(	-LRB-
cord-296347-fanlvxqs	1210	6	cytotoxic	cytotoxic	JJ
cord-296347-fanlvxqs	1210	7	T	T	NNP
cord-296347-fanlvxqs	1210	8	lymphocyte	lymphocyte	NN
cord-296347-fanlvxqs	1210	9	antigen	antigen	NN
cord-296347-fanlvxqs	1210	10	4	4	CD
cord-296347-fanlvxqs	1210	11	)	)	-RRB-
cord-296347-fanlvxqs	1210	12	inhibitory	inhibitory	JJ
cord-296347-fanlvxqs	1210	13	molecules	molecule	NNS
cord-296347-fanlvxqs	1210	14	down	down	RB
cord-296347-fanlvxqs	1210	15	-	-	HYPH
cord-296347-fanlvxqs	1210	16	regulate	regulate	VBP
cord-296347-fanlvxqs	1210	17	the	the	DT
cord-296347-fanlvxqs	1210	18	cytolytic	cytolytic	JJ
cord-296347-fanlvxqs	1210	19	activity	activity	NN
cord-296347-fanlvxqs	1210	20	of	of	IN
cord-296347-fanlvxqs	1210	21	human	human	JJ
cord-296347-fanlvxqs	1210	22	CD4þ	CD4þ	NNP
cord-296347-fanlvxqs	1210	23	T	T	NNP
cord-296347-fanlvxqs	1210	24	-	-	HYPH
cord-296347-fanlvxqs	1210	25	cell	cell	NN
cord-296347-fanlvxqs	1210	26	clones	clone	NNS
cord-296347-fanlvxqs	1210	27	specific	specific	JJ
cord-296347-fanlvxqs	1210	28	for	for	IN
cord-296347-fanlvxqs	1210	29	Mycobacterium	Mycobacterium	NNP
cord-296347-fanlvxqs	1210	30	tuberculosis	tuberculosis	NN
cord-296347-fanlvxqs	1210	31	ERAD	ERAD	NNP
cord-296347-fanlvxqs	1210	32	:	:	:
cord-296347-fanlvxqs	1211	1	The	the	DT
cord-296347-fanlvxqs	1211	2	long	long	JJ
cord-296347-fanlvxqs	1211	3	road	road	NN
cord-296347-fanlvxqs	1211	4	to	to	IN
cord-296347-fanlvxqs	1211	5	destruction	destruction	NN
cord-296347-fanlvxqs	1211	6	Inhibition	inhibition	NN
cord-296347-fanlvxqs	1211	7	of	of	IN
cord-296347-fanlvxqs	1211	8	hepatitis	hepatitis	NN
cord-296347-fanlvxqs	1211	9	C	C	NNP
cord-296347-fanlvxqs	1211	10	virus	virus	NN
cord-296347-fanlvxqs	1211	11	core	core	NN
cord-296347-fanlvxqs	1211	12	protein	protein	NN
cord-296347-fanlvxqs	1211	13	expression	expression	NN
cord-296347-fanlvxqs	1211	14	in	in	IN
cord-296347-fanlvxqs	1211	15	immortalized	immortalize	VBN
cord-296347-fanlvxqs	1211	16	human	human	JJ
cord-296347-fanlvxqs	1211	17	hepatocytes	hepatocyte	NNS
cord-296347-fanlvxqs	1211	18	induces	induce	VBZ
cord-296347-fanlvxqs	1211	19	cytochrome	cytochrome	NN
cord-296347-fanlvxqs	1211	20	c	c	NN
cord-296347-fanlvxqs	1211	21	-	-	HYPH
cord-296347-fanlvxqs	1211	22	independent	independent	JJ
cord-296347-fanlvxqs	1211	23	increase	increase	NN
cord-296347-fanlvxqs	1211	24	in	in	IN
cord-296347-fanlvxqs	1211	25	Apaf-1	Apaf-1	NNP
cord-296347-fanlvxqs	1211	26	and	and	CC
cord-296347-fanlvxqs	1211	27	caspase-9	caspase-9	NNP
cord-296347-fanlvxqs	1211	28	activation	activation	NN
cord-296347-fanlvxqs	1211	29	for	for	IN
cord-296347-fanlvxqs	1211	30	cell	cell	NN
cord-296347-fanlvxqs	1211	31	death	death	NN
cord-296347-fanlvxqs	1212	1	The	the	DT
cord-296347-fanlvxqs	1212	2	deubiquitinating	deubiquitinating	NN
cord-296347-fanlvxqs	1212	3	enzyme	enzyme	NN
cord-296347-fanlvxqs	1212	4	DUB-2	DUB-2	NNP
cord-296347-fanlvxqs	1212	5	prolongs	prolong	VBZ
cord-296347-fanlvxqs	1212	6	cytokine	cytokine	NN
cord-296347-fanlvxqs	1212	7	-	-	HYPH
cord-296347-fanlvxqs	1212	8	induced	induce	VBN
cord-296347-fanlvxqs	1212	9	signal	signal	NN
cord-296347-fanlvxqs	1212	10	transducers	transducer	NNS
cord-296347-fanlvxqs	1212	11	and	and	CC
cord-296347-fanlvxqs	1212	12	activators	activator	NNS
cord-296347-fanlvxqs	1212	13	of	of	IN
cord-296347-fanlvxqs	1212	14	transcription	transcription	NN
cord-296347-fanlvxqs	1212	15	activation	activation	NN
cord-296347-fanlvxqs	1212	16	and	and	CC
cord-296347-fanlvxqs	1212	17	suppresses	suppress	VBZ
cord-296347-fanlvxqs	1212	18	apoptosis	apoptosis	NN
cord-296347-fanlvxqs	1212	19	following	follow	VBG
cord-296347-fanlvxqs	1212	20	cytokine	cytokine	NN
cord-296347-fanlvxqs	1212	21	withdrawal	withdrawal	NN
cord-296347-fanlvxqs	1212	22	Human	human	JJ
cord-296347-fanlvxqs	1212	23	cytomegalovirus	cytomegalovirus	NN
cord-296347-fanlvxqs	1212	24	inhibits	inhibit	VBZ
cord-296347-fanlvxqs	1212	25	major	major	JJ
cord-296347-fanlvxqs	1212	26	histocompatibility	histocompatibility	NN
cord-296347-fanlvxqs	1212	27	complex	complex	JJ
cord-296347-fanlvxqs	1212	28	class	class	NN
cord-296347-fanlvxqs	1212	29	II	ii	CD
cord-296347-fanlvxqs	1212	30	expression	expression	NN
cord-296347-fanlvxqs	1212	31	by	by	IN
cord-296347-fanlvxqs	1212	32	disruption	disruption	NN
cord-296347-fanlvxqs	1212	33	of	of	IN
cord-296347-fanlvxqs	1212	34	the	the	DT
cord-296347-fanlvxqs	1212	35	Jak	Jak	NNP
cord-296347-fanlvxqs	1212	36	/	/	SYM
cord-296347-fanlvxqs	1212	37	Stat	Stat	NNP
cord-296347-fanlvxqs	1212	38	pathway	pathway	NN
cord-296347-fanlvxqs	1212	39	Regulatory	Regulatory	NNP
cord-296347-fanlvxqs	1212	40	T	T	NNP
cord-296347-fanlvxqs	1212	41	cells	cell	NNS
cord-296347-fanlvxqs	1212	42	:	:	:
cord-296347-fanlvxqs	1213	1	Friend	friend	NN
cord-296347-fanlvxqs	1213	2	or	or	CC
cord-296347-fanlvxqs	1213	3	foe	foe	NN
cord-296347-fanlvxqs	1213	4	in	in	IN
cord-296347-fanlvxqs	1213	5	immunity	immunity	NN
cord-296347-fanlvxqs	1213	6	to	to	IN
cord-296347-fanlvxqs	1213	7	infection	infection	NN
cord-296347-fanlvxqs	1213	8	?	?	.
cord-296347-fanlvxqs	1214	1	Structural	structural	JJ
cord-296347-fanlvxqs	1214	2	and	and	CC
cord-296347-fanlvxqs	1214	3	functional	functional	JJ
cord-296347-fanlvxqs	1214	4	analysis	analysis	NN
cord-296347-fanlvxqs	1214	5	of	of	IN
cord-296347-fanlvxqs	1214	6	human	human	JJ
cord-296347-fanlvxqs	1214	7	cytomegalovirus	cytomegalovirus	NN
cord-296347-fanlvxqs	1214	8	US3	US3	NNP
cord-296347-fanlvxqs	1214	9	protein	protein	NN
cord-296347-fanlvxqs	1214	10	Using	use	VBG
cord-296347-fanlvxqs	1214	11	a	a	DT
cord-296347-fanlvxqs	1214	12	small	small	JJ
cord-296347-fanlvxqs	1214	13	molecule	molecule	NN
cord-296347-fanlvxqs	1214	14	inhibitor	inhibitor	NN
cord-296347-fanlvxqs	1214	15	of	of	IN
cord-296347-fanlvxqs	1214	16	peptide	peptide	NN
cord-296347-fanlvxqs	1214	17	:	:	:
cord-296347-fanlvxqs	1215	1	N	n	NN
cord-296347-fanlvxqs	1215	2	-	-	HYPH
cord-296347-fanlvxqs	1215	3	glycanase	glycanase	NN
cord-296347-fanlvxqs	1215	4	to	to	TO
cord-296347-fanlvxqs	1215	5	probe	probe	VB
cord-296347-fanlvxqs	1215	6	its	-PRON-	PRP$
cord-296347-fanlvxqs	1215	7	role	role	NN
cord-296347-fanlvxqs	1215	8	in	in	IN
cord-296347-fanlvxqs	1215	9	glycoprotein	glycoprotein	NN
cord-296347-fanlvxqs	1215	10	turnover	turnover	NN
cord-296347-fanlvxqs	1215	11	Chlamydia	Chlamydia	NNP
cord-296347-fanlvxqs	1215	12	trachomatis	trachomatis	NN
cord-296347-fanlvxqs	1215	13	-	-	HYPH
cord-296347-fanlvxqs	1215	14	derived	derive	VBN
cord-296347-fanlvxqs	1215	15	deubiquitinating	deubiquitinating	NN
cord-296347-fanlvxqs	1215	16	enzymes	enzyme	NNS
cord-296347-fanlvxqs	1215	17	in	in	IN
cord-296347-fanlvxqs	1215	18	mammalian	mammalian	JJ
cord-296347-fanlvxqs	1215	19	cells	cell	NNS
cord-296347-fanlvxqs	1215	20	during	during	IN
cord-296347-fanlvxqs	1215	21	infection	infection	NN
cord-296347-fanlvxqs	1215	22	Immune	immune	VBP
cord-296347-fanlvxqs	1215	23	escape	escape	NN
cord-296347-fanlvxqs	1215	24	and	and	CC
cord-296347-fanlvxqs	1215	25	exploitation	exploitation	NN
cord-296347-fanlvxqs	1215	26	strategies	strategy	NNS
cord-296347-fanlvxqs	1215	27	of	of	IN
cord-296347-fanlvxqs	1215	28	cytomegaloviruses	cytomegalovirus	NNS
cord-296347-fanlvxqs	1215	29	:	:	:
cord-296347-fanlvxqs	1215	30	Impact	impact	NN
cord-296347-fanlvxqs	1215	31	on	on	IN
cord-296347-fanlvxqs	1215	32	and	and	CC
cord-296347-fanlvxqs	1215	33	imitation	imitation	NN
cord-296347-fanlvxqs	1215	34	of	of	IN
cord-296347-fanlvxqs	1215	35	the	the	DT
cord-296347-fanlvxqs	1215	36	major	major	JJ
cord-296347-fanlvxqs	1215	37	histocompatibility	histocompatibility	NN
cord-296347-fanlvxqs	1215	38	system	system	NN
cord-296347-fanlvxqs	1215	39	Role	role	NN
cord-296347-fanlvxqs	1215	40	of	of	IN
cord-296347-fanlvxqs	1215	41	EDEM	EDEM	NNP
cord-296347-fanlvxqs	1215	42	in	in	IN
cord-296347-fanlvxqs	1215	43	the	the	DT
cord-296347-fanlvxqs	1215	44	release	release	NN
cord-296347-fanlvxqs	1215	45	of	of	IN
cord-296347-fanlvxqs	1215	46	misfolded	misfolde	VBN
cord-296347-fanlvxqs	1215	47	glycoproteins	glycoprotein	NNS
cord-296347-fanlvxqs	1215	48	from	from	IN
cord-296347-fanlvxqs	1215	49	the	the	DT
cord-296347-fanlvxqs	1215	50	calnexin	calnexin	NNP
cord-296347-fanlvxqs	1215	51	cycle	cycle	NN
cord-296347-fanlvxqs	1216	1	Selective	selective	JJ
cord-296347-fanlvxqs	1216	2	inhibition	inhibition	NN
cord-296347-fanlvxqs	1216	3	of	of	IN
cord-296347-fanlvxqs	1216	4	Ii	Ii	NNP
cord-296347-fanlvxqs	1216	5	-	-	HYPH
cord-296347-fanlvxqs	1216	6	dependent	dependent	JJ
cord-296347-fanlvxqs	1216	7	antigen	antigen	NN
cord-296347-fanlvxqs	1216	8	presentation	presentation	NN
cord-296347-fanlvxqs	1216	9	by	by	IN
cord-296347-fanlvxqs	1216	10	Helicobacter	Helicobacter	NNP
cord-296347-fanlvxqs	1216	11	pylori	pylori	NN
cord-296347-fanlvxqs	1216	12	toxin	toxin	NN
cord-296347-fanlvxqs	1216	13	VacA	VacA	NNP
cord-296347-fanlvxqs	1216	14	Yersinia	Yersinia	NNP
cord-296347-fanlvxqs	1216	15	YopJ	YopJ	NNP
cord-296347-fanlvxqs	1216	16	acetylates	acetylate	VBZ
cord-296347-fanlvxqs	1216	17	and	and	CC
cord-296347-fanlvxqs	1216	18	inhibits	inhibit	VBZ
cord-296347-fanlvxqs	1216	19	kinase	kinase	NN
cord-296347-fanlvxqs	1216	20	activation	activation	NN
cord-296347-fanlvxqs	1216	21	by	by	IN
cord-296347-fanlvxqs	1216	22	blocking	block	VBG
cord-296347-fanlvxqs	1216	23	phosphorylation	phosphorylation	NN
cord-296347-fanlvxqs	1217	1	Doa1	Doa1	NNP
cord-296347-fanlvxqs	1217	2	is	be	VBZ
cord-296347-fanlvxqs	1217	3	a	a	DT
cord-296347-fanlvxqs	1217	4	Cdc48	Cdc48	NNP
cord-296347-fanlvxqs	1217	5	adapter	adapter	NN
cord-296347-fanlvxqs	1217	6	that	that	WDT
cord-296347-fanlvxqs	1217	7	possesses	possess	VBZ
cord-296347-fanlvxqs	1217	8	a	a	DT
cord-296347-fanlvxqs	1217	9	novel	novel	JJ
cord-296347-fanlvxqs	1217	10	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1217	11	binding	bind	VBG
cord-296347-fanlvxqs	1217	12	domain	domain	NN
cord-296347-fanlvxqs	1217	13	Dendritic	dendritic	JJ
cord-296347-fanlvxqs	1217	14	cell	cell	NN
cord-296347-fanlvxqs	1217	15	maturation	maturation	NN
cord-296347-fanlvxqs	1217	16	by	by	IN
cord-296347-fanlvxqs	1217	17	innate	innate	JJ
cord-296347-fanlvxqs	1217	18	lymphocytes	lymphocyte	NNS
cord-296347-fanlvxqs	1217	19	:	:	:
cord-296347-fanlvxqs	1218	1	Coordinated	coordinated	JJ
cord-296347-fanlvxqs	1218	2	stimulation	stimulation	NN
cord-296347-fanlvxqs	1218	3	of	of	IN
cord-296347-fanlvxqs	1218	4	innate	innate	JJ
cord-296347-fanlvxqs	1218	5	and	and	CC
cord-296347-fanlvxqs	1218	6	adaptive	adaptive	JJ
cord-296347-fanlvxqs	1218	7	immunity	immunity	NN
cord-296347-fanlvxqs	1218	8	CHIP	chip	NN
cord-296347-fanlvxqs	1218	9	is	be	VBZ
cord-296347-fanlvxqs	1218	10	a	a	DT
cord-296347-fanlvxqs	1218	11	chaperonedependent	chaperonedependent	NN
cord-296347-fanlvxqs	1218	12	E3	e3	NN
cord-296347-fanlvxqs	1218	13	ligase	ligase	NN
cord-296347-fanlvxqs	1218	14	that	that	WDT
cord-296347-fanlvxqs	1218	15	ubiquitylates	ubiquitylate	NNS
cord-296347-fanlvxqs	1218	16	unfolded	unfold	VBD
cord-296347-fanlvxqs	1218	17	protein	protein	NN
cord-296347-fanlvxqs	1218	18	CHIP	chip	NN
cord-296347-fanlvxqs	1218	19	:	:	:
cord-296347-fanlvxqs	1219	1	A	a	DT
cord-296347-fanlvxqs	1219	2	quality	quality	NN
cord-296347-fanlvxqs	1219	3	-	-	HYPH
cord-296347-fanlvxqs	1219	4	control	control	NN
cord-296347-fanlvxqs	1219	5	E3	e3	NN
cord-296347-fanlvxqs	1219	6	ligase	ligase	NN
cord-296347-fanlvxqs	1219	7	collaborating	collaborate	VBG
cord-296347-fanlvxqs	1219	8	with	with	IN
cord-296347-fanlvxqs	1219	9	molecular	molecular	JJ
cord-296347-fanlvxqs	1219	10	chaperones	chaperone	NNS
cord-296347-fanlvxqs	1219	11	Autocrine	Autocrine	NNP
cord-296347-fanlvxqs	1219	12	motility	motility	NN
cord-296347-fanlvxqs	1219	13	factor	factor	NN
cord-296347-fanlvxqs	1219	14	and	and	CC
cord-296347-fanlvxqs	1219	15	its	-PRON-	PRP$
cord-296347-fanlvxqs	1219	16	receptor	receptor	NN
cord-296347-fanlvxqs	1219	17	:	:	:
cord-296347-fanlvxqs	1219	18	Role	role	NN
cord-296347-fanlvxqs	1219	19	in	in	IN
cord-296347-fanlvxqs	1219	20	cell	cell	NN
cord-296347-fanlvxqs	1219	21	locomotion	locomotion	NN
cord-296347-fanlvxqs	1219	22	and	and	CC
cord-296347-fanlvxqs	1219	23	metastasis	metastasis	NN
cord-296347-fanlvxqs	1220	1	A	a	DT
cord-296347-fanlvxqs	1220	2	novel	novel	JJ
cord-296347-fanlvxqs	1220	3	route	route	NN
cord-296347-fanlvxqs	1220	4	for	for	IN
cord-296347-fanlvxqs	1220	5	F	F	NNP
cord-296347-fanlvxqs	1220	6	-	-	HYPH
cord-296347-fanlvxqs	1220	7	box	box	NNP
cord-296347-fanlvxqs	1220	8	protein	protein	NN
cord-296347-fanlvxqs	1220	9	mediated	mediate	VBD
cord-296347-fanlvxqs	1220	10	ubiquitination	ubiquitination	NN
cord-296347-fanlvxqs	1220	11	links	link	VBZ
cord-296347-fanlvxqs	1220	12	CHIP	chip	NN
cord-296347-fanlvxqs	1220	13	to	to	IN
cord-296347-fanlvxqs	1220	14	glycoprotein	glycoprotein	NN
cord-296347-fanlvxqs	1220	15	quality	quality	NN
cord-296347-fanlvxqs	1220	16	control	control	NN
cord-296347-fanlvxqs	1220	17	Ubx2	Ubx2	NNP
cord-296347-fanlvxqs	1220	18	links	link	VBZ
cord-296347-fanlvxqs	1220	19	the	the	DT
cord-296347-fanlvxqs	1220	20	Cdc48	Cdc48	NNP
cord-296347-fanlvxqs	1220	21	complex	complex	JJ
cord-296347-fanlvxqs	1220	22	to	to	IN
cord-296347-fanlvxqs	1220	23	ER	ER	NNP
cord-296347-fanlvxqs	1220	24	-	-	HYPH
cord-296347-fanlvxqs	1220	25	associated	associate	VBN
cord-296347-fanlvxqs	1220	26	protein	protein	NN
cord-296347-fanlvxqs	1220	27	degradation	degradation	NN
cord-296347-fanlvxqs	1220	28	Herpes	Herpes	NNP
cord-296347-fanlvxqs	1220	29	simplex	simplex	NN
cord-296347-fanlvxqs	1220	30	virus	virus	NN
cord-296347-fanlvxqs	1220	31	type	type	NN
cord-296347-fanlvxqs	1220	32	1	1	CD
cord-296347-fanlvxqs	1220	33	targets	target	VBZ
cord-296347-fanlvxqs	1220	34	the	the	DT
cord-296347-fanlvxqs	1220	35	MHC	MHC	NNP
cord-296347-fanlvxqs	1220	36	class	class	NN
cord-296347-fanlvxqs	1220	37	II	II	NNP
cord-296347-fanlvxqs	1220	38	processing	processing	NN
cord-296347-fanlvxqs	1220	39	pathway	pathway	NN
cord-296347-fanlvxqs	1220	40	for	for	IN
cord-296347-fanlvxqs	1220	41	immune	immune	JJ
cord-296347-fanlvxqs	1220	42	evasion	evasion	NN
cord-296347-fanlvxqs	1221	1	A	a	DT
cord-296347-fanlvxqs	1221	2	genomic	genomic	JJ
cord-296347-fanlvxqs	1221	3	and	and	CC
cord-296347-fanlvxqs	1221	4	functional	functional	JJ
cord-296347-fanlvxqs	1221	5	inventory	inventory	NN
cord-296347-fanlvxqs	1221	6	of	of	IN
cord-296347-fanlvxqs	1221	7	deubiquitinating	deubiquitinating	NN
cord-296347-fanlvxqs	1221	8	enzymes	enzyme	NNS
cord-296347-fanlvxqs	1222	1	Derlin-2	Derlin-2	NNP
cord-296347-fanlvxqs	1223	1	and	and	CC
cord-296347-fanlvxqs	1223	2	Derlin-3	Derlin-3	NNP
cord-296347-fanlvxqs	1223	3	are	be	VBP
cord-296347-fanlvxqs	1223	4	regulated	regulate	VBN
cord-296347-fanlvxqs	1223	5	by	by	IN
cord-296347-fanlvxqs	1223	6	the	the	DT
cord-296347-fanlvxqs	1223	7	mammalian	mammalian	JJ
cord-296347-fanlvxqs	1223	8	unfolded	unfold	VBD
cord-296347-fanlvxqs	1223	9	protein	protein	NN
cord-296347-fanlvxqs	1223	10	response	response	NN
cord-296347-fanlvxqs	1223	11	and	and	CC
cord-296347-fanlvxqs	1223	12	are	be	VBP
cord-296347-fanlvxqs	1223	13	required	require	VBN
cord-296347-fanlvxqs	1223	14	for	for	IN
cord-296347-fanlvxqs	1223	15	ER	ER	NNP
cord-296347-fanlvxqs	1223	16	-	-	HYPH
cord-296347-fanlvxqs	1223	17	associated	associate	VBN
cord-296347-fanlvxqs	1223	18	degradation	degradation	NN
cord-296347-fanlvxqs	1223	19	Mitochondrial	mitochondrial	JJ
cord-296347-fanlvxqs	1223	20	injury	injury	NN
cord-296347-fanlvxqs	1223	21	,	,	,
cord-296347-fanlvxqs	1223	22	oxidative	oxidative	JJ
cord-296347-fanlvxqs	1223	23	stress	stress	NN
cord-296347-fanlvxqs	1223	24	,	,	,
cord-296347-fanlvxqs	1223	25	and	and	CC
cord-296347-fanlvxqs	1223	26	antioxidant	antioxidant	JJ
cord-296347-fanlvxqs	1223	27	gene	gene	NN
cord-296347-fanlvxqs	1223	28	expression	expression	NN
cord-296347-fanlvxqs	1223	29	are	be	VBP
cord-296347-fanlvxqs	1223	30	induced	induce	VBN
cord-296347-fanlvxqs	1223	31	by	by	IN
cord-296347-fanlvxqs	1223	32	hepatitis	hepatitis	NNP
cord-296347-fanlvxqs	1223	33	C	C	NNP
cord-296347-fanlvxqs	1223	34	virus	virus	NN
cord-296347-fanlvxqs	1223	35	core	core	NN
cord-296347-fanlvxqs	1223	36	protein	protein	NN
cord-296347-fanlvxqs	1223	37	Innate	innate	VBP
cord-296347-fanlvxqs	1223	38	antiviral	antiviral	JJ
cord-296347-fanlvxqs	1223	39	response	response	NN
cord-296347-fanlvxqs	1223	40	targets	target	NNS
cord-296347-fanlvxqs	1223	41	HIV-1	HIV-1	NNP
cord-296347-fanlvxqs	1223	42	release	release	NN
cord-296347-fanlvxqs	1223	43	by	by	IN
cord-296347-fanlvxqs	1223	44	the	the	DT
cord-296347-fanlvxqs	1223	45	induction	induction	NN
cord-296347-fanlvxqs	1223	46	of	of	IN
cord-296347-fanlvxqs	1223	47	ubiquitin	ubiquitin	JJ
cord-296347-fanlvxqs	1223	48	-	-	HYPH
cord-296347-fanlvxqs	1223	49	like	like	JJ
cord-296347-fanlvxqs	1223	50	protein	protein	NN
cord-296347-fanlvxqs	1223	51	ISG15	ISG15	NNP
cord-296347-fanlvxqs	1223	52	Core	Core	NNP
cord-296347-fanlvxqs	1223	53	protein	protein	NN
cord-296347-fanlvxqs	1223	54	of	of	IN
cord-296347-fanlvxqs	1223	55	hepatitis	hepatitis	NN
cord-296347-fanlvxqs	1223	56	C	C	NNP
cord-296347-fanlvxqs	1223	57	virus	virus	NN
cord-296347-fanlvxqs	1223	58	induces	induce	VBZ
cord-296347-fanlvxqs	1223	59	cardiomyopathy	cardiomyopathy	NN
cord-296347-fanlvxqs	1223	60	How	how	WRB
cord-296347-fanlvxqs	1223	61	calmodulin	calmodulin	NN
cord-296347-fanlvxqs	1223	62	binds	bind	VBZ
cord-296347-fanlvxqs	1223	63	its	-PRON-	PRP$
cord-296347-fanlvxqs	1223	64	targets	target	NNS
cord-296347-fanlvxqs	1223	65	:	:	:
cord-296347-fanlvxqs	1223	66	Sequence	sequence	NN
cord-296347-fanlvxqs	1223	67	independent	independent	JJ
cord-296347-fanlvxqs	1223	68	recognition	recognition	NN
cord-296347-fanlvxqs	1223	69	of	of	IN
cord-296347-fanlvxqs	1223	70	amphiphilic	amphiphilic	JJ
cord-296347-fanlvxqs	1223	71	alpha	alpha	NN
cord-296347-fanlvxqs	1223	72	-	-	HYPH
cord-296347-fanlvxqs	1223	73	helices	helix	NNS
cord-296347-fanlvxqs	1223	74	Viral	viral	JJ
cord-296347-fanlvxqs	1223	75	evasion	evasion	NN
cord-296347-fanlvxqs	1223	76	of	of	IN
cord-296347-fanlvxqs	1223	77	natural	natural	JJ
cord-296347-fanlvxqs	1223	78	killer	killer	NN
cord-296347-fanlvxqs	1223	79	cells	cell	NNS
cord-296347-fanlvxqs	1224	1	A	a	DT
cord-296347-fanlvxqs	1224	2	structural	structural	JJ
cord-296347-fanlvxqs	1224	3	determinant	determinant	NN
cord-296347-fanlvxqs	1224	4	of	of	IN
cord-296347-fanlvxqs	1224	5	HCMV	HCMV	NNP
cord-296347-fanlvxqs	1224	6	US2	US2	NNP
cord-296347-fanlvxqs	1224	7	dictates	dictate	VBZ
cord-296347-fanlvxqs	1224	8	the	the	DT
cord-296347-fanlvxqs	1224	9	down	down	JJ
cord-296347-fanlvxqs	1224	10	-	-	HYPH
cord-296347-fanlvxqs	1224	11	regulation	regulation	NN
cord-296347-fanlvxqs	1224	12	of	of	IN
cord-296347-fanlvxqs	1224	13	class	class	NN
cord-296347-fanlvxqs	1225	1	I	-PRON-	PRP
cord-296347-fanlvxqs	1225	2	MHC	MHC	NNP
cord-296347-fanlvxqs	1225	3	molecules	molecule	NNS
cord-296347-fanlvxqs	1225	4	Function	Function	NNP
cord-296347-fanlvxqs	1225	5	of	of	IN
cord-296347-fanlvxqs	1225	6	the	the	DT
cord-296347-fanlvxqs	1225	7	Yersinia	Yersinia	NNP
cord-296347-fanlvxqs	1225	8	effector	effector	VB
cord-296347-fanlvxqs	1225	9	Yop	Yop	NNP
cord-296347-fanlvxqs	1225	10	Disruption	Disruption	NNP
cord-296347-fanlvxqs	1225	11	of	of	IN
cord-296347-fanlvxqs	1225	12	signaling	signal	VBG
cord-296347-fanlvxqs	1225	13	by	by	IN
cord-296347-fanlvxqs	1225	14	Yersinia	Yersinia	NNP
cord-296347-fanlvxqs	1225	15	effector	effector	NNP
cord-296347-fanlvxqs	1226	1	YopJ	YopJ	NNP
cord-296347-fanlvxqs	1226	2	,	,	,
cord-296347-fanlvxqs	1226	3	a	a	DT
cord-296347-fanlvxqs	1226	4	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1226	5	-	-	HYPH
cord-296347-fanlvxqs	1226	6	like	like	JJ
cord-296347-fanlvxqs	1226	7	protein	protein	NN
cord-296347-fanlvxqs	1226	8	protease	protease	NN
cord-296347-fanlvxqs	1226	9	A	a	DT
cord-296347-fanlvxqs	1226	10	single	single	JJ
cord-296347-fanlvxqs	1226	11	residue	residue	NN
cord-296347-fanlvxqs	1226	12	exchange	exchange	NN
cord-296347-fanlvxqs	1226	13	within	within	IN
cord-296347-fanlvxqs	1226	14	a	a	DT
cord-296347-fanlvxqs	1226	15	viral	viral	JJ
cord-296347-fanlvxqs	1226	16	CTL	ctl	NN
cord-296347-fanlvxqs	1226	17	epitope	epitope	NN
cord-296347-fanlvxqs	1226	18	alters	alter	VBZ
cord-296347-fanlvxqs	1226	19	proteasome	proteasome	VBN
cord-296347-fanlvxqs	1226	20	-	-	HYPH
cord-296347-fanlvxqs	1226	21	mediated	mediate	VBN
cord-296347-fanlvxqs	1226	22	degradation	degradation	NN
cord-296347-fanlvxqs	1226	23	resulting	result	VBG
cord-296347-fanlvxqs	1226	24	in	in	IN
cord-296347-fanlvxqs	1226	25	lack	lack	NN
cord-296347-fanlvxqs	1226	26	of	of	IN
cord-296347-fanlvxqs	1226	27	antigen	antigen	NN
cord-296347-fanlvxqs	1226	28	presentation	presentation	NN
cord-296347-fanlvxqs	1226	29	Mechanisms	Mechanisms	NNPS
cord-296347-fanlvxqs	1226	30	of	of	IN
cord-296347-fanlvxqs	1226	31	MHC	MHC	NNP
cord-296347-fanlvxqs	1226	32	class	class	NN
cord-296347-fanlvxqs	1226	33	I	i	NN
cord-296347-fanlvxqs	1226	34	-	-	HYPH
cord-296347-fanlvxqs	1226	35	restricted	restrict	VBN
cord-296347-fanlvxqs	1226	36	antigen	antigen	NN
cord-296347-fanlvxqs	1226	37	processing	processing	NN
cord-296347-fanlvxqs	1226	38	Nedd8	nedd8	RB
cord-296347-fanlvxqs	1226	39	on	on	IN
cord-296347-fanlvxqs	1226	40	cullin	cullin	NNP
cord-296347-fanlvxqs	1226	41	:	:	:
cord-296347-fanlvxqs	1226	42	Building	build	VBG
cord-296347-fanlvxqs	1226	43	an	an	DT
cord-296347-fanlvxqs	1226	44	expressway	expressway	NN
cord-296347-fanlvxqs	1226	45	to	to	IN
cord-296347-fanlvxqs	1226	46	protein	protein	NN
cord-296347-fanlvxqs	1226	47	destruction	destruction	NN
cord-296347-fanlvxqs	1227	1	Presenilin	Presenilin	NNP
cord-296347-fanlvxqs	1227	2	attenuates	attenuate	VBZ
cord-296347-fanlvxqs	1227	3	receptor	receptor	NN
cord-296347-fanlvxqs	1227	4	-	-	HYPH
cord-296347-fanlvxqs	1227	5	mediated	mediate	VBN
cord-296347-fanlvxqs	1227	6	signaling	signaling	NN
cord-296347-fanlvxqs	1227	7	and	and	CC
cord-296347-fanlvxqs	1227	8	synaptic	synaptic	JJ
cord-296347-fanlvxqs	1227	9	function	function	NN
cord-296347-fanlvxqs	1228	1	Human	human	JJ
cord-296347-fanlvxqs	1228	2	cytomegalovirus	cytomegalovirus	NN
cord-296347-fanlvxqs	1228	3	inhibits	inhibit	VBZ
cord-296347-fanlvxqs	1228	4	tapasin	tapasin	NN
cord-296347-fanlvxqs	1228	5	-	-	HYPH
cord-296347-fanlvxqs	1228	6	dependent	dependent	JJ
cord-296347-fanlvxqs	1228	7	peptide	peptide	NN
cord-296347-fanlvxqs	1228	8	loading	loading	NN
cord-296347-fanlvxqs	1228	9	and	and	CC
cord-296347-fanlvxqs	1228	10	optimization	optimization	NN
cord-296347-fanlvxqs	1228	11	of	of	IN
cord-296347-fanlvxqs	1228	12	the	the	DT
cord-296347-fanlvxqs	1228	13	MHC	MHC	NNP
cord-296347-fanlvxqs	1228	14	class	class	NN
cord-296347-fanlvxqs	1228	15	I	-PRON-	PRP
cord-296347-fanlvxqs	1228	16	peptide	peptide	JJ
cord-296347-fanlvxqs	1228	17	cargo	cargo	NN
cord-296347-fanlvxqs	1228	18	for	for	IN
cord-296347-fanlvxqs	1228	19	immune	immune	JJ
cord-296347-fanlvxqs	1228	20	evasion	evasion	NN
cord-296347-fanlvxqs	1228	21	F	F	NNP
cord-296347-fanlvxqs	1228	22	-	-	HYPH
cord-296347-fanlvxqs	1228	23	box	box	NN
cord-296347-fanlvxqs	1228	24	-	-	HYPH
cord-296347-fanlvxqs	1228	25	like	like	JJ
cord-296347-fanlvxqs	1228	26	domain	domain	NN
cord-296347-fanlvxqs	1228	27	in	in	IN
cord-296347-fanlvxqs	1228	28	the	the	DT
cord-296347-fanlvxqs	1228	29	polerovirus	polerovirus	NNP
cord-296347-fanlvxqs	1228	30	protein	protein	NN
cord-296347-fanlvxqs	1228	31	P0	p0	NN
cord-296347-fanlvxqs	1228	32	is	be	VBZ
cord-296347-fanlvxqs	1228	33	required	require	VBN
cord-296347-fanlvxqs	1228	34	for	for	IN
cord-296347-fanlvxqs	1228	35	silencing	silence	VBG
cord-296347-fanlvxqs	1228	36	suppressor	suppressor	NN
cord-296347-fanlvxqs	1228	37	function	function	NN
cord-296347-fanlvxqs	1228	38	Function	function	NN
cord-296347-fanlvxqs	1228	39	and	and	CC
cord-296347-fanlvxqs	1228	40	regulation	regulation	NN
cord-296347-fanlvxqs	1228	41	of	of	IN
cord-296347-fanlvxqs	1228	42	cullin	cullin	NN
cord-296347-fanlvxqs	1228	43	-	-	HYPH
cord-296347-fanlvxqs	1228	44	RING	ring	NN
cord-296347-fanlvxqs	1228	45	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1228	46	ligases	ligase	NNS
cord-296347-fanlvxqs	1229	1	Mechanisms	mechanism	NNS
cord-296347-fanlvxqs	1229	2	underlying	underlie	VBG
cord-296347-fanlvxqs	1229	3	ubiquitination	ubiquitination	IN
cord-296347-fanlvxqs	1229	4	Back	back	RB
cord-296347-fanlvxqs	1229	5	to	to	IN
cord-296347-fanlvxqs	1229	6	the	the	DT
cord-296347-fanlvxqs	1229	7	future	future	NN
cord-296347-fanlvxqs	1229	8	with	with	IN
cord-296347-fanlvxqs	1229	9	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1229	10	Ubiquitin	Ubiquitin	NNP
cord-296347-fanlvxqs	1229	11	:	:	:
cord-296347-fanlvxqs	1229	12	Structures	structure	NNS
cord-296347-fanlvxqs	1229	13	,	,	,
cord-296347-fanlvxqs	1229	14	functions	function	NNS
cord-296347-fanlvxqs	1229	15	,	,	,
cord-296347-fanlvxqs	1229	16	mechanisms	mechanism	VBZ
cord-296347-fanlvxqs	1229	17	HLA	HLA	NNP
cord-296347-fanlvxqs	1229	18	-	-	HYPH
cord-296347-fanlvxqs	1229	19	E	e	NN
cord-296347-fanlvxqs	1229	20	-	-	HYPH
cord-296347-fanlvxqs	1229	21	restricted	restricted	JJ
cord-296347-fanlvxqs	1229	22	recognition	recognition	NN
cord-296347-fanlvxqs	1229	23	of	of	IN
cord-296347-fanlvxqs	1229	24	cytomegalovirus	cytomegalovirus	NN
cord-296347-fanlvxqs	1229	25	-	-	HYPH
cord-296347-fanlvxqs	1229	26	derived	derive	VBN
cord-296347-fanlvxqs	1229	27	peptides	peptide	NNS
cord-296347-fanlvxqs	1229	28	by	by	IN
cord-296347-fanlvxqs	1229	29	human	human	JJ
cord-296347-fanlvxqs	1229	30	CD8þ	CD8þ	NNP
cord-296347-fanlvxqs	1229	31	cytolytic	cytolytic	VBD
cord-296347-fanlvxqs	1229	32	T	t	NN
cord-296347-fanlvxqs	1229	33	lymphocytes	lymphocyte	NNS
cord-296347-fanlvxqs	1229	34	Mechanism	mechanism	NN
cord-296347-fanlvxqs	1229	35	of	of	IN
cord-296347-fanlvxqs	1229	36	Nef	Nef	NNP
cord-296347-fanlvxqs	1229	37	-	-	HYPH
cord-296347-fanlvxqs	1229	38	induced	induce	VBN
cord-296347-fanlvxqs	1229	39	CD4	CD4	NNP
cord-296347-fanlvxqs	1229	40	endocytosis	endocytosis	NN
cord-296347-fanlvxqs	1229	41	:	:	:
cord-296347-fanlvxqs	1229	42	Nef	Nef	NNP
cord-296347-fanlvxqs	1229	43	connects	connect	VBZ
cord-296347-fanlvxqs	1229	44	CD4	CD4	NNP
cord-296347-fanlvxqs	1229	45	with	with	IN
cord-296347-fanlvxqs	1229	46	the	the	DT
cord-296347-fanlvxqs	1229	47	mu	mu	NN
cord-296347-fanlvxqs	1229	48	chain	chain	NN
cord-296347-fanlvxqs	1229	49	of	of	IN
cord-296347-fanlvxqs	1229	50	adaptor	adaptor	NN
cord-296347-fanlvxqs	1229	51	complexes	complex	NNS
cord-296347-fanlvxqs	1229	52	Nef	Nef	NNP
cord-296347-fanlvxqs	1229	53	-	-	HYPH
cord-296347-fanlvxqs	1229	54	induced	induce	VBN
cord-296347-fanlvxqs	1229	55	CD4	CD4	NNP
cord-296347-fanlvxqs	1229	56	degradation	degradation	NN
cord-296347-fanlvxqs	1229	57	:	:	:
cord-296347-fanlvxqs	1229	58	A	a	DT
cord-296347-fanlvxqs	1229	59	diacidic	diacidic	NN
cord-296347-fanlvxqs	1229	60	-	-	HYPH
cord-296347-fanlvxqs	1229	61	based	base	VBN
cord-296347-fanlvxqs	1229	62	motif	motif	NN
cord-296347-fanlvxqs	1229	63	in	in	IN
cord-296347-fanlvxqs	1229	64	Nef	Nef	NNP
cord-296347-fanlvxqs	1229	65	functions	function	NNS
cord-296347-fanlvxqs	1229	66	as	as	IN
cord-296347-fanlvxqs	1229	67	a	a	DT
cord-296347-fanlvxqs	1229	68	lysosomal	lysosomal	JJ
cord-296347-fanlvxqs	1229	69	targeting	target	VBG
cord-296347-fanlvxqs	1229	70	signal	signal	NN
cord-296347-fanlvxqs	1229	71	through	through	IN
cord-296347-fanlvxqs	1229	72	the	the	DT
cord-296347-fanlvxqs	1229	73	binding	binding	NN
cord-296347-fanlvxqs	1229	74	of	of	IN
cord-296347-fanlvxqs	1229	75	beta	beta	NN
cord-296347-fanlvxqs	1229	76	-	-	HYPH
cord-296347-fanlvxqs	1229	77	COP	cop	NN
cord-296347-fanlvxqs	1229	78	in	in	IN
cord-296347-fanlvxqs	1229	79	endosomes	endosome	NNS
cord-296347-fanlvxqs	1230	1	The	the	DT
cord-296347-fanlvxqs	1230	2	downregulation	downregulation	NN
cord-296347-fanlvxqs	1230	3	of	of	IN
cord-296347-fanlvxqs	1230	4	CD4	CD4	NNP
cord-296347-fanlvxqs	1230	5	and	and	CC
cord-296347-fanlvxqs	1230	6	MHC	MHC	NNP
cord-296347-fanlvxqs	1230	7	-	-	HYPH
cord-296347-fanlvxqs	1230	8	I	I	NNP
cord-296347-fanlvxqs	1230	9	by	by	IN
cord-296347-fanlvxqs	1230	10	primate	primate	JJ
cord-296347-fanlvxqs	1230	11	lentiviruses	lentiviruse	NNS
cord-296347-fanlvxqs	1230	12	:	:	:
cord-296347-fanlvxqs	1230	13	A	a	DT
cord-296347-fanlvxqs	1230	14	paradigm	paradigm	NN
cord-296347-fanlvxqs	1230	15	for	for	IN
cord-296347-fanlvxqs	1230	16	the	the	DT
cord-296347-fanlvxqs	1230	17	modulation	modulation	NN
cord-296347-fanlvxqs	1230	18	of	of	IN
cord-296347-fanlvxqs	1230	19	cell	cell	NN
cord-296347-fanlvxqs	1230	20	surface	surface	NN
cord-296347-fanlvxqs	1230	21	receptors	receptor	NNS
cord-296347-fanlvxqs	1231	1	Sec61p	Sec61p	NNP
cord-296347-fanlvxqs	1231	2	mediates	mediate	VBZ
cord-296347-fanlvxqs	1231	3	export	export	NN
cord-296347-fanlvxqs	1231	4	of	of	IN
cord-296347-fanlvxqs	1231	5	a	a	DT
cord-296347-fanlvxqs	1231	6	misfolded	misfolde	VBN
cord-296347-fanlvxqs	1231	7	secretory	secretory	JJ
cord-296347-fanlvxqs	1231	8	protein	protein	NN
cord-296347-fanlvxqs	1231	9	from	from	IN
cord-296347-fanlvxqs	1231	10	the	the	DT
cord-296347-fanlvxqs	1231	11	endoplasmic	endoplasmic	NN
cord-296347-fanlvxqs	1231	12	reticulum	reticulum	NN
cord-296347-fanlvxqs	1231	13	to	to	IN
cord-296347-fanlvxqs	1231	14	the	the	DT
cord-296347-fanlvxqs	1231	15	cytosol	cytosol	NN
cord-296347-fanlvxqs	1231	16	for	for	IN
cord-296347-fanlvxqs	1231	17	degradation	degradation	NN
cord-296347-fanlvxqs	1231	18	Viral	viral	JJ
cord-296347-fanlvxqs	1231	19	interference	interference	NN
cord-296347-fanlvxqs	1231	20	with	with	IN
cord-296347-fanlvxqs	1231	21	antigen	antigen	NN
cord-296347-fanlvxqs	1231	22	presentation	presentation	NN
cord-296347-fanlvxqs	1231	23	to	to	IN
cord-296347-fanlvxqs	1231	24	CD8þ	CD8þ	NNP
cord-296347-fanlvxqs	1231	25	T	T	NNP
cord-296347-fanlvxqs	1231	26	cells	cell	NNS
cord-296347-fanlvxqs	1231	27	:	:	:
cord-296347-fanlvxqs	1232	1	Lessons	lesson	NNS
cord-296347-fanlvxqs	1232	2	from	from	IN
cord-296347-fanlvxqs	1232	3	cytomegalovirus	cytomegalovirus	JJ
cord-296347-fanlvxqs	1232	4	Multiple	multiple	JJ
cord-296347-fanlvxqs	1232	5	effects	effect	NNS
cord-296347-fanlvxqs	1232	6	of	of	IN
cord-296347-fanlvxqs	1232	7	interferon	interferon	NN
cord-296347-fanlvxqs	1232	8	on	on	IN
cord-296347-fanlvxqs	1232	9	the	the	DT
cord-296347-fanlvxqs	1232	10	replication	replication	NN
cord-296347-fanlvxqs	1232	11	of	of	IN
cord-296347-fanlvxqs	1232	12	human	human	JJ
cord-296347-fanlvxqs	1232	13	immunodeficiency	immunodeficiency	NN
cord-296347-fanlvxqs	1232	14	virus	virus	NN
cord-296347-fanlvxqs	1232	15	type	type	NN
cord-296347-fanlvxqs	1232	16	1	1	CD
cord-296347-fanlvxqs	1232	17	Bacterial	bacterial	JJ
cord-296347-fanlvxqs	1232	18	adhesion	adhesion	NN
cord-296347-fanlvxqs	1232	19	and	and	CC
cord-296347-fanlvxqs	1232	20	entry	entry	NN
cord-296347-fanlvxqs	1232	21	into	into	IN
cord-296347-fanlvxqs	1232	22	host	host	NN
cord-296347-fanlvxqs	1232	23	cells	cell	NNS
cord-296347-fanlvxqs	1232	24	Mutant	mutant	JJ
cord-296347-fanlvxqs	1232	25	analysis	analysis	NN
cord-296347-fanlvxqs	1232	26	links	link	VBZ
cord-296347-fanlvxqs	1232	27	the	the	DT
cord-296347-fanlvxqs	1232	28	translocon	translocon	NNP
cord-296347-fanlvxqs	1232	29	and	and	CC
cord-296347-fanlvxqs	1232	30	BiP	BiP	NNP
cord-296347-fanlvxqs	1232	31	to	to	TO
cord-296347-fanlvxqs	1232	32	retrograde	retrograde	JJ
cord-296347-fanlvxqs	1232	33	protein	protein	NN
cord-296347-fanlvxqs	1232	34	transport	transport	NN
cord-296347-fanlvxqs	1232	35	for	for	IN
cord-296347-fanlvxqs	1232	36	ER	ER	NNP
cord-296347-fanlvxqs	1232	37	degradation	degradation	NN
cord-296347-fanlvxqs	1232	38	Endoplasmic	Endoplasmic	NNP
cord-296347-fanlvxqs	1232	39	reticulum	reticulum	NN
cord-296347-fanlvxqs	1232	40	degradation	degradation	NN
cord-296347-fanlvxqs	1232	41	of	of	IN
cord-296347-fanlvxqs	1232	42	a	a	DT
cord-296347-fanlvxqs	1232	43	mutated	mutate	VBN
cord-296347-fanlvxqs	1232	44	ATP	ATP	NNP
cord-296347-fanlvxqs	1232	45	-	-	HYPH
cord-296347-fanlvxqs	1232	46	binding	bind	VBG
cord-296347-fanlvxqs	1232	47	cassette	cassette	NN
cord-296347-fanlvxqs	1232	48	transporter	transporter	NN
cord-296347-fanlvxqs	1232	49	Pdr5	Pdr5	NNP
cord-296347-fanlvxqs	1232	50	proceeds	proceed	VBZ
cord-296347-fanlvxqs	1232	51	in	in	IN
cord-296347-fanlvxqs	1232	52	a	a	DT
cord-296347-fanlvxqs	1232	53	concerted	concerted	JJ
cord-296347-fanlvxqs	1232	54	action	action	NN
cord-296347-fanlvxqs	1232	55	of	of	IN
cord-296347-fanlvxqs	1232	56	Sec61	Sec61	NNP
cord-296347-fanlvxqs	1232	57	and	and	CC
cord-296347-fanlvxqs	1232	58	the	the	DT
cord-296347-fanlvxqs	1232	59	proteasome	proteasome	VBN
cord-296347-fanlvxqs	1232	60	Viral	viral	JJ
cord-296347-fanlvxqs	1232	61	strategies	strategy	NNS
cord-296347-fanlvxqs	1232	62	of	of	IN
cord-296347-fanlvxqs	1232	63	immune	immune	JJ
cord-296347-fanlvxqs	1232	64	evasion	evasion	NN
cord-296347-fanlvxqs	1232	65	Interferon	interferon	NN
cord-296347-fanlvxqs	1232	66	-	-	HYPH
cord-296347-fanlvxqs	1232	67	alpha	alpha	NN
cord-296347-fanlvxqs	1232	68	but	but	CC
cord-296347-fanlvxqs	1233	1	not	not	RB
cord-296347-fanlvxqs	1233	2	AZT	AZT	NNP
cord-296347-fanlvxqs	1233	3	suppresses	suppress	VBZ
cord-296347-fanlvxqs	1233	4	HIV	HIV	NNP
cord-296347-fanlvxqs	1233	5	expression	expression	NN
cord-296347-fanlvxqs	1233	6	in	in	IN
cord-296347-fanlvxqs	1233	7	chronically	chronically	RB
cord-296347-fanlvxqs	1233	8	infected	infect	VBN
cord-296347-fanlvxqs	1233	9	cell	cell	NN
cord-296347-fanlvxqs	1233	10	lines	line	NNS
cord-296347-fanlvxqs	1233	11	Structure	Structure	NNP
cord-296347-fanlvxqs	1233	12	of	of	IN
cord-296347-fanlvxqs	1233	13	the	the	DT
cord-296347-fanlvxqs	1233	14	Tsg101	tsg101	CD
cord-296347-fanlvxqs	1233	15	UEV	UEV	NNP
cord-296347-fanlvxqs	1233	16	domain	domain	NN
cord-296347-fanlvxqs	1233	17	in	in	IN
cord-296347-fanlvxqs	1233	18	complex	complex	NN
cord-296347-fanlvxqs	1233	19	with	with	IN
cord-296347-fanlvxqs	1233	20	the	the	DT
cord-296347-fanlvxqs	1233	21	PTAP	ptap	JJ
cord-296347-fanlvxqs	1233	22	motif	motif	NN
cord-296347-fanlvxqs	1233	23	of	of	IN
cord-296347-fanlvxqs	1233	24	the	the	DT
cord-296347-fanlvxqs	1233	25	HIV-1	HIV-1	NNP
cord-296347-fanlvxqs	1233	26	p6	p6	NN
cord-296347-fanlvxqs	1233	27	protein	protein	NN
cord-296347-fanlvxqs	1233	28	HIV	HIV	NNP
cord-296347-fanlvxqs	1233	29	Gag	Gag	NNP
cord-296347-fanlvxqs	1233	30	mimics	mimic	VBZ
cord-296347-fanlvxqs	1233	31	the	the	DT
cord-296347-fanlvxqs	1233	32	Tsg101-recruiting	tsg101-recruiting	NN
cord-296347-fanlvxqs	1233	33	activity	activity	NN
cord-296347-fanlvxqs	1233	34	of	of	IN
cord-296347-fanlvxqs	1233	35	the	the	DT
cord-296347-fanlvxqs	1233	36	human	human	JJ
cord-296347-fanlvxqs	1233	37	Hrs	Hrs	NNP
cord-296347-fanlvxqs	1233	38	protein	protein	NN
cord-296347-fanlvxqs	1233	39	Mutants	mutant	NNS
cord-296347-fanlvxqs	1233	40	affecting	affect	VBG
cord-296347-fanlvxqs	1233	41	the	the	DT
cord-296347-fanlvxqs	1233	42	structure	structure	NN
cord-296347-fanlvxqs	1233	43	of	of	IN
cord-296347-fanlvxqs	1233	44	the	the	DT
cord-296347-fanlvxqs	1233	45	cortical	cortical	JJ
cord-296347-fanlvxqs	1233	46	endoplasmic	endoplasmic	NN
cord-296347-fanlvxqs	1233	47	reticulum	reticulum	NN
cord-296347-fanlvxqs	1233	48	in	in	IN
cord-296347-fanlvxqs	1233	49	Saccharomyces	Saccharomyces	NNP
cord-296347-fanlvxqs	1233	50	cerevisiae	cerevisiae	NNS
cord-296347-fanlvxqs	1233	51	Translating	translate	VBG
cord-296347-fanlvxqs	1233	52	innate	innate	JJ
cord-296347-fanlvxqs	1233	53	immunity	immunity	NN
cord-296347-fanlvxqs	1233	54	into	into	IN
cord-296347-fanlvxqs	1233	55	immunological	immunological	JJ
cord-296347-fanlvxqs	1233	56	memory	memory	NN
cord-296347-fanlvxqs	1233	57	:	:	:
cord-296347-fanlvxqs	1233	58	Implications	implication	NNS
cord-296347-fanlvxqs	1233	59	for	for	IN
cord-296347-fanlvxqs	1233	60	vaccine	vaccine	NN
cord-296347-fanlvxqs	1233	61	development	development	NN
cord-296347-fanlvxqs	1234	1	Viral	viral	JJ
cord-296347-fanlvxqs	1234	2	evasion	evasion	NN
cord-296347-fanlvxqs	1234	3	of	of	IN
cord-296347-fanlvxqs	1234	4	NK	nk	NN
cord-296347-fanlvxqs	1234	5	-	-	HYPH
cord-296347-fanlvxqs	1234	6	cell	cell	NN
cord-296347-fanlvxqs	1234	7	activation	activation	NN
cord-296347-fanlvxqs	1234	8	Specific	specific	JJ
cord-296347-fanlvxqs	1234	9	inhibition	inhibition	NN
cord-296347-fanlvxqs	1234	10	of	of	IN
cord-296347-fanlvxqs	1234	11	type	type	NN
cord-296347-fanlvxqs	1235	1	I	-PRON-	PRP
cord-296347-fanlvxqs	1235	2	interferon	interferon	RB
cord-296347-fanlvxqs	1235	3	signal	signal	VBP
cord-296347-fanlvxqs	1235	4	transduction	transduction	NN
cord-296347-fanlvxqs	1235	5	by	by	IN
cord-296347-fanlvxqs	1235	6	respiratory	respiratory	JJ
cord-296347-fanlvxqs	1235	7	syncytial	syncytial	JJ
cord-296347-fanlvxqs	1235	8	virus	virus	NN
cord-296347-fanlvxqs	1235	9	Survival	Survival	NNP
cord-296347-fanlvxqs	1235	10	of	of	IN
cord-296347-fanlvxqs	1235	11	the	the	DT
cord-296347-fanlvxqs	1235	12	fitters	fitter	NNS
cord-296347-fanlvxqs	1235	13	Immunology	Immunology	NNP
cord-296347-fanlvxqs	1235	14	:	:	:
cord-296347-fanlvxqs	1235	15	Protein	protein	NN
cord-296347-fanlvxqs	1235	16	surgery	surgery	NN
cord-296347-fanlvxqs	1235	17	Membrane	membrane	NN
cord-296347-fanlvxqs	1235	18	and	and	CC
cord-296347-fanlvxqs	1235	19	soluble	soluble	JJ
cord-296347-fanlvxqs	1235	20	substrates	substrate	NNS
cord-296347-fanlvxqs	1235	21	of	of	IN
cord-296347-fanlvxqs	1235	22	the	the	DT
cord-296347-fanlvxqs	1235	23	Doa10	Doa10	NNP
cord-296347-fanlvxqs	1235	24	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1235	25	ligase	ligase	NN
cord-296347-fanlvxqs	1235	26	are	be	VBP
cord-296347-fanlvxqs	1235	27	degraded	degrade	VBN
cord-296347-fanlvxqs	1235	28	by	by	IN
cord-296347-fanlvxqs	1235	29	distinct	distinct	JJ
cord-296347-fanlvxqs	1235	30	pathways	pathway	NNS
cord-296347-fanlvxqs	1235	31	Antigens	Antigens	NNPS
cord-296347-fanlvxqs	1235	32	and	and	CC
cord-296347-fanlvxqs	1235	33	immunoevasins	immunoevasin	NNS
cord-296347-fanlvxqs	1235	34	:	:	:
cord-296347-fanlvxqs	1235	35	Opponents	opponent	NNS
cord-296347-fanlvxqs	1235	36	in	in	IN
cord-296347-fanlvxqs	1235	37	cytomegalovirus	cytomegalovirus	JJ
cord-296347-fanlvxqs	1235	38	immune	immune	JJ
cord-296347-fanlvxqs	1235	39	surveillance	surveillance	NN
cord-296347-fanlvxqs	1235	40	Human	human	JJ
cord-296347-fanlvxqs	1235	41	cytomegalovirus	cytomegalovirus	NN
cord-296347-fanlvxqs	1235	42	gene	gene	NN
cord-296347-fanlvxqs	1235	43	products	product	NNS
cord-296347-fanlvxqs	1235	44	US2	US2	NNP
cord-296347-fanlvxqs	1235	45	and	and	CC
cord-296347-fanlvxqs	1235	46	US11	US11	NNP
cord-296347-fanlvxqs	1235	47	differ	differ	VBP
cord-296347-fanlvxqs	1235	48	in	in	IN
cord-296347-fanlvxqs	1235	49	their	-PRON-	PRP$
cord-296347-fanlvxqs	1235	50	ability	ability	NN
cord-296347-fanlvxqs	1235	51	to	to	TO
cord-296347-fanlvxqs	1235	52	attack	attack	VB
cord-296347-fanlvxqs	1235	53	major	major	JJ
cord-296347-fanlvxqs	1235	54	histocompatibility	histocompatibility	NN
cord-296347-fanlvxqs	1235	55	class	class	NN
cord-296347-fanlvxqs	1236	1	I	-PRON-	PRP
cord-296347-fanlvxqs	1236	2	heavy	heavy	JJ
cord-296347-fanlvxqs	1236	3	chains	chain	NNS
cord-296347-fanlvxqs	1236	4	in	in	IN
cord-296347-fanlvxqs	1236	5	dendritic	dendritic	JJ
cord-296347-fanlvxqs	1236	6	cells	cell	NNS
cord-296347-fanlvxqs	1236	7	Interference	Interference	NNP
cord-296347-fanlvxqs	1236	8	with	with	IN
cord-296347-fanlvxqs	1236	9	T	T	NNP
cord-296347-fanlvxqs	1236	10	cell	cell	NN
cord-296347-fanlvxqs	1236	11	receptor	receptor	NN
cord-296347-fanlvxqs	1236	12	-	-	:
cord-296347-fanlvxqs	1236	13	HLA	HLA	NNP
cord-296347-fanlvxqs	1236	14	-	-	HYPH
cord-296347-fanlvxqs	1236	15	DR	DR	NNP
cord-296347-fanlvxqs	1236	16	interactions	interaction	NNS
cord-296347-fanlvxqs	1236	17	by	by	IN
cord-296347-fanlvxqs	1236	18	Epstein	Epstein	NNP
cord-296347-fanlvxqs	1236	19	-	-	HYPH
cord-296347-fanlvxqs	1236	20	Barr	Barr	NNP
cord-296347-fanlvxqs	1236	21	virus	virus	NN
cord-296347-fanlvxqs	1236	22	gp42	gp42	WDT
cord-296347-fanlvxqs	1236	23	results	result	VBZ
cord-296347-fanlvxqs	1236	24	in	in	IN
cord-296347-fanlvxqs	1236	25	reduced	reduce	VBN
cord-296347-fanlvxqs	1236	26	T	T	NNP
cord-296347-fanlvxqs	1236	27	helper	helper	NN
cord-296347-fanlvxqs	1236	28	cell	cell	NN
cord-296347-fanlvxqs	1236	29	recognition	recognition	NN
cord-296347-fanlvxqs	1237	1	Epstein	Epstein	NNP
cord-296347-fanlvxqs	1237	2	-	-	HYPH
cord-296347-fanlvxqs	1237	3	Barr	Barr	NNP
cord-296347-fanlvxqs	1237	4	virus	virus	NN
cord-296347-fanlvxqs	1237	5	gp42	gp42	NNP
cord-296347-fanlvxqs	1237	6	is	be	VBZ
cord-296347-fanlvxqs	1237	7	posttranslationally	posttranslationally	RB
cord-296347-fanlvxqs	1237	8	modified	modify	VBN
cord-296347-fanlvxqs	1237	9	to	to	TO
cord-296347-fanlvxqs	1237	10	produce	produce	VB
cord-296347-fanlvxqs	1237	11	soluble	soluble	JJ
cord-296347-fanlvxqs	1237	12	gp42	gp42	NNS
cord-296347-fanlvxqs	1237	13	that	that	WDT
cord-296347-fanlvxqs	1237	14	mediates	mediate	VBZ
cord-296347-fanlvxqs	1237	15	HLA	HLA	NNP
cord-296347-fanlvxqs	1237	16	class	class	NN
cord-296347-fanlvxqs	1237	17	II	ii	CD
cord-296347-fanlvxqs	1237	18	immune	immune	JJ
cord-296347-fanlvxqs	1237	19	evasion	evasion	NN
cord-296347-fanlvxqs	1238	1	The	the	DT
cord-296347-fanlvxqs	1238	2	class	class	NN
cord-296347-fanlvxqs	1238	3	I	-PRON-	PRP
cord-296347-fanlvxqs	1238	4	MHC	MHC	NNP
cord-296347-fanlvxqs	1238	5	homologue	homologue	NN
cord-296347-fanlvxqs	1238	6	of	of	IN
cord-296347-fanlvxqs	1238	7	human	human	JJ
cord-296347-fanlvxqs	1238	8	cytomegalovirus	cytomegalovirus	NN
cord-296347-fanlvxqs	1238	9	inhibits	inhibit	VBZ
cord-296347-fanlvxqs	1238	10	attack	attack	NN
cord-296347-fanlvxqs	1238	11	by	by	IN
cord-296347-fanlvxqs	1238	12	natural	natural	JJ
cord-296347-fanlvxqs	1238	13	killer	killer	NN
cord-296347-fanlvxqs	1238	14	cells	cell	NNS
cord-296347-fanlvxqs	1239	1	The	the	DT
cord-296347-fanlvxqs	1239	2	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1239	3	binding	bind	VBG
cord-296347-fanlvxqs	1239	4	domain	domain	NN
cord-296347-fanlvxqs	1239	5	ZnF	znf	NN
cord-296347-fanlvxqs	1239	6	UBP	UBP	NNP
cord-296347-fanlvxqs	1239	7	recognizes	recognize	VBZ
cord-296347-fanlvxqs	1239	8	the	the	DT
cord-296347-fanlvxqs	1239	9	C	C	NNP
cord-296347-fanlvxqs	1239	10	-	-	HYPH
cord-296347-fanlvxqs	1239	11	terminal	terminal	NN
cord-296347-fanlvxqs	1239	12	diglycine	diglycine	NN
cord-296347-fanlvxqs	1239	13	motif	motif	NN
cord-296347-fanlvxqs	1239	14	of	of	IN
cord-296347-fanlvxqs	1239	15	unanchored	unanchored	JJ
cord-296347-fanlvxqs	1239	16	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1239	17	A	a	DT
cord-296347-fanlvxqs	1239	18	series	series	NN
cord-296347-fanlvxqs	1239	19	of	of	IN
cord-296347-fanlvxqs	1239	20	ubiquitin	ubiquitin	JJ
cord-296347-fanlvxqs	1239	21	binding	binding	NN
cord-296347-fanlvxqs	1239	22	factors	factor	NNS
cord-296347-fanlvxqs	1239	23	connects	connect	VBZ
cord-296347-fanlvxqs	1239	24	CDC48	cdc48	NN
cord-296347-fanlvxqs	1239	25	/	/	SYM
cord-296347-fanlvxqs	1239	26	p97	p97	CD
cord-296347-fanlvxqs	1239	27	to	to	IN
cord-296347-fanlvxqs	1239	28	substrate	substrate	NN
cord-296347-fanlvxqs	1239	29	multiubiquitylation	multiubiquitylation	NN
cord-296347-fanlvxqs	1239	30	and	and	CC
cord-296347-fanlvxqs	1239	31	proteasomal	proteasomal	NNP
cord-296347-fanlvxqs	1239	32	targeting	target	VBG
cord-296347-fanlvxqs	1239	33	Modulation	modulation	NN
cord-296347-fanlvxqs	1239	34	of	of	IN
cord-296347-fanlvxqs	1239	35	major	major	JJ
cord-296347-fanlvxqs	1239	36	histocompatibility	histocompatibility	NN
cord-296347-fanlvxqs	1239	37	complex	complex	JJ
cord-296347-fanlvxqs	1239	38	antigen	antigen	NN
cord-296347-fanlvxqs	1239	39	expression	expression	NN
cord-296347-fanlvxqs	1239	40	by	by	IN
cord-296347-fanlvxqs	1239	41	viral	viral	JJ
cord-296347-fanlvxqs	1239	42	infection	infection	NN
cord-296347-fanlvxqs	1240	1	ISG15	isg15	NN
cord-296347-fanlvxqs	1240	2	:	:	:
cord-296347-fanlvxqs	1241	1	The	the	DT
cord-296347-fanlvxqs	1241	2	immunological	immunological	JJ
cord-296347-fanlvxqs	1241	3	kin	kin	NN
cord-296347-fanlvxqs	1241	4	of	of	IN
cord-296347-fanlvxqs	1241	5	ubiquitin	ubiquitin	JJ
cord-296347-fanlvxqs	1241	6	Dysregulation	Dysregulation	NNP
cord-296347-fanlvxqs	1241	7	of	of	IN
cord-296347-fanlvxqs	1241	8	protein	protein	NN
cord-296347-fanlvxqs	1241	9	modification	modification	NN
cord-296347-fanlvxqs	1241	10	by	by	IN
cord-296347-fanlvxqs	1241	11	ISG15	isg15	NN
cord-296347-fanlvxqs	1241	12	results	result	NNS
cord-296347-fanlvxqs	1241	13	in	in	IN
cord-296347-fanlvxqs	1241	14	brain	brain	NN
cord-296347-fanlvxqs	1241	15	cell	cell	NN
cord-296347-fanlvxqs	1241	16	injury	injury	NN
cord-296347-fanlvxqs	1241	17	Proteasome	Proteasome	NNP
cord-296347-fanlvxqs	1241	18	function	function	NN
cord-296347-fanlvxqs	1241	19	in	in	IN
cord-296347-fanlvxqs	1241	20	antigen	antigen	NN
cord-296347-fanlvxqs	1241	21	presentation	presentation	NN
cord-296347-fanlvxqs	1241	22	:	:	:
cord-296347-fanlvxqs	1242	1	Immunoproteasome	Immunoproteasome	NNP
cord-296347-fanlvxqs	1242	2	complexes	complex	NNS
cord-296347-fanlvxqs	1242	3	,	,	,
cord-296347-fanlvxqs	1242	4	peptide	peptide	JJ
cord-296347-fanlvxqs	1242	5	production	production	NN
cord-296347-fanlvxqs	1242	6	,	,	,
cord-296347-fanlvxqs	1242	7	and	and	CC
cord-296347-fanlvxqs	1242	8	interactions	interaction	NNS
cord-296347-fanlvxqs	1242	9	with	with	IN
cord-296347-fanlvxqs	1242	10	viral	viral	JJ
cord-296347-fanlvxqs	1242	11	proteins	protein	NNS
cord-296347-fanlvxqs	1242	12	Regulation	regulation	NN
cord-296347-fanlvxqs	1242	13	of	of	IN
cord-296347-fanlvxqs	1242	14	proteasome	proteasome	VBN
cord-296347-fanlvxqs	1242	15	structure	structure	NN
cord-296347-fanlvxqs	1242	16	and	and	CC
cord-296347-fanlvxqs	1242	17	function	function	VB
cord-296347-fanlvxqs	1242	18	HLA	HLA	NNP
cord-296347-fanlvxqs	1242	19	-	-	HYPH
cord-296347-fanlvxqs	1242	20	E	e	NN
cord-296347-fanlvxqs	1242	21	-	-	HYPH
cord-296347-fanlvxqs	1242	22	restricted	restricted	JJ
cord-296347-fanlvxqs	1242	23	recognition	recognition	NN
cord-296347-fanlvxqs	1242	24	of	of	IN
cord-296347-fanlvxqs	1242	25	human	human	JJ
cord-296347-fanlvxqs	1242	26	cytomegalovirus	cytomegalovirus	NN
cord-296347-fanlvxqs	1242	27	by	by	IN
cord-296347-fanlvxqs	1242	28	a	a	DT
cord-296347-fanlvxqs	1242	29	subset	subset	NN
cord-296347-fanlvxqs	1242	30	of	of	IN
cord-296347-fanlvxqs	1242	31	cytolytic	cytolytic	JJ
cord-296347-fanlvxqs	1242	32	T	t	NN
cord-296347-fanlvxqs	1242	33	lymphocytes	lymphocyte	NNS
cord-296347-fanlvxqs	1242	34	Endoplasmic	Endoplasmic	NNP
cord-296347-fanlvxqs	1242	35	reticulum	reticulum	NN
cord-296347-fanlvxqs	1242	36	-	-	HYPH
cord-296347-fanlvxqs	1242	37	associated	associate	VBN
cord-296347-fanlvxqs	1242	38	degradation	degradation	NN
cord-296347-fanlvxqs	1242	39	Cdc48p	Cdc48p	NNP
cord-296347-fanlvxqs	1242	40	is	be	VBZ
cord-296347-fanlvxqs	1242	41	UBX	UBX	NNP
cord-296347-fanlvxqs	1242	42	-	-	HYPH
cord-296347-fanlvxqs	1242	43	linked	link	VBN
cord-296347-fanlvxqs	1242	44	to	to	IN
cord-296347-fanlvxqs	1242	45	ER	ER	NNP
cord-296347-fanlvxqs	1242	46	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1242	47	ligases	ligase	NNS
cord-296347-fanlvxqs	1243	1	Complete	complete	JJ
cord-296347-fanlvxqs	1243	2	differentiation	differentiation	NN
cord-296347-fanlvxqs	1243	3	between	between	IN
cord-296347-fanlvxqs	1243	4	enkephalinase	enkephalinase	NN
cord-296347-fanlvxqs	1243	5	and	and	CC
cord-296347-fanlvxqs	1243	6	angiotensin	angiotensin	NN
cord-296347-fanlvxqs	1243	7	-	-	HYPH
cord-296347-fanlvxqs	1243	8	converting	convert	VBG
cord-296347-fanlvxqs	1243	9	enzyme	enzyme	NN
cord-296347-fanlvxqs	1243	10	inhibition	inhibition	NN
cord-296347-fanlvxqs	1243	11	by	by	IN
cord-296347-fanlvxqs	1243	12	retro	retro	JJ
cord-296347-fanlvxqs	1243	13	-	-	HYPH
cord-296347-fanlvxqs	1243	14	thiorphan	thiorphan	NNP
cord-296347-fanlvxqs	1243	15	CD4	CD4	NNP
cord-296347-fanlvxqs	1243	16	down	down	IN
cord-296347-fanlvxqs	1243	17	-	-	HYPH
cord-296347-fanlvxqs	1243	18	regulation	regulation	NN
cord-296347-fanlvxqs	1243	19	by	by	IN
cord-296347-fanlvxqs	1243	20	HIV-1	HIV-1	NNP
cord-296347-fanlvxqs	1243	21	and	and	CC
cord-296347-fanlvxqs	1243	22	simian	simian	JJ
cord-296347-fanlvxqs	1243	23	immunodeficiency	immunodeficiency	NN
cord-296347-fanlvxqs	1243	24	virus	virus	NN
cord-296347-fanlvxqs	1243	25	(	(	-LRB-
cord-296347-fanlvxqs	1243	26	SIV	SIV	NNP
cord-296347-fanlvxqs	1243	27	)	)	-RRB-
cord-296347-fanlvxqs	1243	28	Nef	Nef	NNP
cord-296347-fanlvxqs	1243	29	proteins	protein	NNS
cord-296347-fanlvxqs	1243	30	involves	involve	VBZ
cord-296347-fanlvxqs	1243	31	both	both	CC
cord-296347-fanlvxqs	1243	32	internalization	internalization	NN
cord-296347-fanlvxqs	1243	33	and	and	CC
cord-296347-fanlvxqs	1243	34	intracellular	intracellular	JJ
cord-296347-fanlvxqs	1243	35	retention	retention	NN
cord-296347-fanlvxqs	1243	36	mechanisms	mechanism	NNS
cord-296347-fanlvxqs	1243	37	Inhibition	Inhibition	NNP
cord-296347-fanlvxqs	1243	38	of	of	IN
cord-296347-fanlvxqs	1243	39	HIV-1	HIV-1	NNP
cord-296347-fanlvxqs	1243	40	progeny	progeny	NN
cord-296347-fanlvxqs	1243	41	virion	virion	NN
cord-296347-fanlvxqs	1243	42	release	release	NN
cord-296347-fanlvxqs	1243	43	by	by	IN
cord-296347-fanlvxqs	1243	44	cell	cell	NN
cord-296347-fanlvxqs	1243	45	-	-	HYPH
cord-296347-fanlvxqs	1243	46	surface	surface	NN
cord-296347-fanlvxqs	1243	47	CD4	CD4	NNP
cord-296347-fanlvxqs	1243	48	is	be	VBZ
cord-296347-fanlvxqs	1243	49	relieved	relieve	VBN
cord-296347-fanlvxqs	1243	50	by	by	IN
cord-296347-fanlvxqs	1243	51	expression	expression	NN
cord-296347-fanlvxqs	1243	52	of	of	IN
cord-296347-fanlvxqs	1243	53	the	the	DT
cord-296347-fanlvxqs	1243	54	viral	viral	JJ
cord-296347-fanlvxqs	1243	55	Nef	Nef	NNP
cord-296347-fanlvxqs	1243	56	protein	protein	NN
cord-296347-fanlvxqs	1244	1	The	the	DT
cord-296347-fanlvxqs	1244	2	specificity	specificity	NN
cord-296347-fanlvxqs	1244	3	of	of	IN
cord-296347-fanlvxqs	1244	4	TCR	TCR	NNP
cord-296347-fanlvxqs	1244	5	/	/	:
cord-296347-fanlvxqs	1244	6	pMHC	pmhc	JJ
cord-296347-fanlvxqs	1244	7	interaction	interaction	NN
cord-296347-fanlvxqs	1244	8	Functional	functional	JJ
cord-296347-fanlvxqs	1244	9	division	division	NN
cord-296347-fanlvxqs	1244	10	of	of	IN
cord-296347-fanlvxqs	1244	11	substrate	substrate	NN
cord-296347-fanlvxqs	1244	12	processing	processing	NN
cord-296347-fanlvxqs	1244	13	cofactors	cofactor	NNS
cord-296347-fanlvxqs	1244	14	of	of	IN
cord-296347-fanlvxqs	1244	15	the	the	DT
cord-296347-fanlvxqs	1244	16	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1244	17	-	-	HYPH
cord-296347-fanlvxqs	1244	18	selective	selective	JJ
cord-296347-fanlvxqs	1244	19	Cdc48	Cdc48	NNP
cord-296347-fanlvxqs	1244	20	chaperone	chaperone	NN
cord-296347-fanlvxqs	1245	1	In	in	IN
cord-296347-fanlvxqs	1245	2	vivo	vivo	NN
cord-296347-fanlvxqs	1245	3	evidence	evidence	NN
cord-296347-fanlvxqs	1245	4	of	of	IN
cord-296347-fanlvxqs	1245	5	CHIP	chip	NN
cord-296347-fanlvxqs	1245	6	up	up	IN
cord-296347-fanlvxqs	1245	7	-	-	HYPH
cord-296347-fanlvxqs	1245	8	regulation	regulation	NN
cord-296347-fanlvxqs	1245	9	attenuating	attenuate	VBG
cord-296347-fanlvxqs	1245	10	tau	tau	NNP
cord-296347-fanlvxqs	1245	11	aggregation	aggregation	NN
cord-296347-fanlvxqs	1246	1	Endoplasmic	Endoplasmic	NNP
cord-296347-fanlvxqs	1246	2	reticulum	reticulum	NN
cord-296347-fanlvxqs	1246	3	stress	stress	NN
cord-296347-fanlvxqs	1246	4	-	-	HYPH
cord-296347-fanlvxqs	1246	5	inducible	inducible	JJ
cord-296347-fanlvxqs	1246	6	protein	protein	NN
cord-296347-fanlvxqs	1246	7	,	,	,
cord-296347-fanlvxqs	1246	8	Herp	Herp	NNP
cord-296347-fanlvxqs	1246	9	,	,	,
cord-296347-fanlvxqs	1246	10	enhances	enhance	VBZ
cord-296347-fanlvxqs	1246	11	presenilin	presenilin	NN
cord-296347-fanlvxqs	1246	12	-	-	HYPH
cord-296347-fanlvxqs	1246	13	mediated	mediate	VBN
cord-296347-fanlvxqs	1246	14	generation	generation	NN
cord-296347-fanlvxqs	1246	15	of	of	IN
cord-296347-fanlvxqs	1246	16	amyloid	amyloid	NN
cord-296347-fanlvxqs	1246	17	beta	beta	NN
cord-296347-fanlvxqs	1246	18	-	-	HYPH
cord-296347-fanlvxqs	1246	19	protein	protein	NN
cord-296347-fanlvxqs	1246	20	Regulation	regulation	NN
cord-296347-fanlvxqs	1246	21	of	of	IN
cord-296347-fanlvxqs	1246	22	human	human	JJ
cord-296347-fanlvxqs	1246	23	T	t	NN
cord-296347-fanlvxqs	1246	24	-	-	HYPH
cord-296347-fanlvxqs	1246	25	cell	cell	NN
cord-296347-fanlvxqs	1246	26	leukemia	leukemia	NN
cord-296347-fanlvxqs	1246	27	virus	virus	NN
cord-296347-fanlvxqs	1246	28	type	type	NN
cord-296347-fanlvxqs	1246	29	1	1	CD
cord-296347-fanlvxqs	1246	30	(	(	-LRB-
cord-296347-fanlvxqs	1246	31	HTLV-1	HTLV-1	NNP
cord-296347-fanlvxqs	1246	32	)	)	-RRB-
cord-296347-fanlvxqs	1246	33	budding	bud	VBG
cord-296347-fanlvxqs	1246	34	by	by	IN
cord-296347-fanlvxqs	1246	35	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1246	36	ligase	ligase	NN
cord-296347-fanlvxqs	1247	1	Nedd4	Nedd4	NNP
cord-296347-fanlvxqs	1248	1	Calling	call	VBG
cord-296347-fanlvxqs	1248	2	in	in	IN
cord-296347-fanlvxqs	1248	3	the	the	DT
cord-296347-fanlvxqs	1248	4	troops	troop	NNS
cord-296347-fanlvxqs	1248	5	:	:	:
cord-296347-fanlvxqs	1248	6	Regulation	regulation	NN
cord-296347-fanlvxqs	1248	7	of	of	IN
cord-296347-fanlvxqs	1248	8	inflammatory	inflammatory	JJ
cord-296347-fanlvxqs	1248	9	cell	cell	NN
cord-296347-fanlvxqs	1248	10	trafficking	traffic	VBG
cord-296347-fanlvxqs	1248	11	through	through	IN
cord-296347-fanlvxqs	1248	12	innate	innate	JJ
cord-296347-fanlvxqs	1248	13	cytokine	cytokine	NN
cord-296347-fanlvxqs	1248	14	/	/	SYM
cord-296347-fanlvxqs	1248	15	chemokine	chemokine	NN
cord-296347-fanlvxqs	1248	16	networks	network	NNS
cord-296347-fanlvxqs	1248	17	Cytokine	cytokine	NN
cord-296347-fanlvxqs	1248	18	and	and	CC
cord-296347-fanlvxqs	1248	19	chemokine	chemokine	NN
cord-296347-fanlvxqs	1248	20	networks	network	NNS
cord-296347-fanlvxqs	1248	21	:	:	:
cord-296347-fanlvxqs	1248	22	Pathways	pathway	NNS
cord-296347-fanlvxqs	1248	23	to	to	IN
cord-296347-fanlvxqs	1248	24	antiviral	antiviral	JJ
cord-296347-fanlvxqs	1248	25	defense	defense	NN
cord-296347-fanlvxqs	1248	26	Functional	functional	JJ
cord-296347-fanlvxqs	1248	27	organization	organization	NN
cord-296347-fanlvxqs	1248	28	of	of	IN
cord-296347-fanlvxqs	1248	29	MIR2	MIR2	NNP
cord-296347-fanlvxqs	1248	30	,	,	,
cord-296347-fanlvxqs	1248	31	a	a	DT
cord-296347-fanlvxqs	1248	32	novel	novel	JJ
cord-296347-fanlvxqs	1248	33	viral	viral	JJ
cord-296347-fanlvxqs	1248	34	regulator	regulator	NN
cord-296347-fanlvxqs	1248	35	of	of	IN
cord-296347-fanlvxqs	1248	36	selective	selective	JJ
cord-296347-fanlvxqs	1248	37	endocytosis	endocytosis	NN
cord-296347-fanlvxqs	1249	1	The	the	DT
cord-296347-fanlvxqs	1249	2	CD85	CD85	NNP
cord-296347-fanlvxqs	1249	3	/	/	SYM
cord-296347-fanlvxqs	1249	4	LIR-1	LIR-1	NNP
cord-296347-fanlvxqs	1249	5	/	/	SYM
cord-296347-fanlvxqs	1249	6	ILT2	ilt2	JJ
cord-296347-fanlvxqs	1249	7	inhibitory	inhibitory	JJ
cord-296347-fanlvxqs	1249	8	receptor	receptor	NN
cord-296347-fanlvxqs	1249	9	is	be	VBZ
cord-296347-fanlvxqs	1249	10	expressed	express	VBN
cord-296347-fanlvxqs	1249	11	by	by	IN
cord-296347-fanlvxqs	1249	12	all	all	DT
cord-296347-fanlvxqs	1249	13	human	human	JJ
cord-296347-fanlvxqs	1249	14	T	t	NN
cord-296347-fanlvxqs	1249	15	lymphocytes	lymphocyte	NNS
cord-296347-fanlvxqs	1249	16	and	and	CC
cord-296347-fanlvxqs	1249	17	down	down	RB
cord-296347-fanlvxqs	1249	18	-	-	HYPH
cord-296347-fanlvxqs	1249	19	regulates	regulate	VBZ
cord-296347-fanlvxqs	1249	20	their	-PRON-	PRP$
cord-296347-fanlvxqs	1249	21	functions	function	NNS
cord-296347-fanlvxqs	1249	22	Specific	specific	JJ
cord-296347-fanlvxqs	1249	23	recognition	recognition	NN
cord-296347-fanlvxqs	1249	24	of	of	IN
cord-296347-fanlvxqs	1249	25	the	the	DT
cord-296347-fanlvxqs	1249	26	viral	viral	JJ
cord-296347-fanlvxqs	1249	27	protein	protein	NN
cord-296347-fanlvxqs	1249	28	UL18	UL18	NNP
cord-296347-fanlvxqs	1249	29	by	by	IN
cord-296347-fanlvxqs	1250	1	CD85j	CD85j	NNP
cord-296347-fanlvxqs	1250	2	/	/	SYM
cord-296347-fanlvxqs	1250	3	LIR-1	LIR-1	NNP
cord-296347-fanlvxqs	1250	4	/	/	SYM
cord-296347-fanlvxqs	1250	5	ILT2	ILT2	NNP
cord-296347-fanlvxqs	1250	6	on	on	IN
cord-296347-fanlvxqs	1250	7	CD8þ	CD8þ	NNP
cord-296347-fanlvxqs	1250	8	T	T	NNP
cord-296347-fanlvxqs	1250	9	cells	cell	NNS
cord-296347-fanlvxqs	1250	10	mediates	mediate	VBZ
cord-296347-fanlvxqs	1250	11	the	the	DT
cord-296347-fanlvxqs	1250	12	non	non	JJ
cord-296347-fanlvxqs	1250	13	-	-	JJ
cord-296347-fanlvxqs	1250	14	MHC	mhc	JJ
cord-296347-fanlvxqs	1250	15	-	-	HYPH
cord-296347-fanlvxqs	1250	16	restricted	restrict	VBN
cord-296347-fanlvxqs	1250	17	lysis	lysis	NN
cord-296347-fanlvxqs	1250	18	of	of	IN
cord-296347-fanlvxqs	1250	19	human	human	JJ
cord-296347-fanlvxqs	1250	20	cytomegalovirus	cytomegalovirus	NN
cord-296347-fanlvxqs	1250	21	-	-	HYPH
cord-296347-fanlvxqs	1250	22	infected	infect	VBN
cord-296347-fanlvxqs	1250	23	cells	cell	NNS
cord-296347-fanlvxqs	1250	24	Rad23	Rad23	NNP
cord-296347-fanlvxqs	1251	1	links	links	NNP
cord-296347-fanlvxqs	1251	2	DNA	DNA	NNP
cord-296347-fanlvxqs	1251	3	repair	repair	NN
cord-296347-fanlvxqs	1251	4	to	to	IN
cord-296347-fanlvxqs	1251	5	the	the	DT
cord-296347-fanlvxqs	1251	6	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1251	7	/	/	SYM
cord-296347-fanlvxqs	1251	8	proteasome	proteasome	NN
cord-296347-fanlvxqs	1251	9	pathway	pathway	NN
cord-296347-fanlvxqs	1252	1	The	the	DT
cord-296347-fanlvxqs	1252	2	HPV-16	HPV-16	NNP
cord-296347-fanlvxqs	1252	3	E6	E6	NNP
cord-296347-fanlvxqs	1252	4	and	and	CC
cord-296347-fanlvxqs	1252	5	E6-AP	e6-ap	JJ
cord-296347-fanlvxqs	1252	6	complex	complex	JJ
cord-296347-fanlvxqs	1252	7	functions	function	NNS
cord-296347-fanlvxqs	1252	8	as	as	IN
cord-296347-fanlvxqs	1252	9	a	a	DT
cord-296347-fanlvxqs	1252	10	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1252	11	-	-	HYPH
cord-296347-fanlvxqs	1252	12	protein	protein	NN
cord-296347-fanlvxqs	1252	13	ligase	ligase	NN
cord-296347-fanlvxqs	1252	14	in	in	IN
cord-296347-fanlvxqs	1252	15	the	the	DT
cord-296347-fanlvxqs	1252	16	ubiquitination	ubiquitination	NN
cord-296347-fanlvxqs	1252	17	of	of	IN
cord-296347-fanlvxqs	1252	18	p53	p53	NN
cord-296347-fanlvxqs	1252	19	A	a	DT
cord-296347-fanlvxqs	1252	20	deubiquitinating	deubiquitinating	NN
cord-296347-fanlvxqs	1252	21	activity	activity	NN
cord-296347-fanlvxqs	1252	22	is	be	VBZ
cord-296347-fanlvxqs	1252	23	conserved	conserve	VBN
cord-296347-fanlvxqs	1252	24	in	in	IN
cord-296347-fanlvxqs	1252	25	the	the	DT
cord-296347-fanlvxqs	1252	26	large	large	JJ
cord-296347-fanlvxqs	1252	27	tegument	tegument	NN
cord-296347-fanlvxqs	1252	28	protein	protein	NN
cord-296347-fanlvxqs	1252	29	of	of	IN
cord-296347-fanlvxqs	1252	30	the	the	DT
cord-296347-fanlvxqs	1252	31	herpesviridae	herpesviridae	NNP
cord-296347-fanlvxqs	1252	32	Proteasome	Proteasome	NNP
cord-296347-fanlvxqs	1252	33	-	-	HYPH
cord-296347-fanlvxqs	1252	34	associated	associate	VBN
cord-296347-fanlvxqs	1252	35	proteins	protein	NNS
cord-296347-fanlvxqs	1252	36	:	:	:
cord-296347-fanlvxqs	1252	37	Regulation	regulation	NN
cord-296347-fanlvxqs	1252	38	of	of	IN
cord-296347-fanlvxqs	1252	39	a	a	DT
cord-296347-fanlvxqs	1252	40	proteolytic	proteolytic	JJ
cord-296347-fanlvxqs	1252	41	machine	machine	NN
cord-296347-fanlvxqs	1252	42	CD4	CD4	NNP
cord-296347-fanlvxqs	1252	43	glycoprotein	glycoprotein	NN
cord-296347-fanlvxqs	1252	44	degradation	degradation	NN
cord-296347-fanlvxqs	1252	45	induced	induce	VBN
cord-296347-fanlvxqs	1252	46	by	by	IN
cord-296347-fanlvxqs	1252	47	human	human	JJ
cord-296347-fanlvxqs	1252	48	immunodeficiency	immunodeficiency	NN
cord-296347-fanlvxqs	1252	49	virus	virus	NN
cord-296347-fanlvxqs	1252	50	type	type	NN
cord-296347-fanlvxqs	1252	51	1	1	CD
cord-296347-fanlvxqs	1252	52	Vpu	Vpu	NNP
cord-296347-fanlvxqs	1252	53	protein	protein	NN
cord-296347-fanlvxqs	1252	54	requires	require	VBZ
cord-296347-fanlvxqs	1252	55	the	the	DT
cord-296347-fanlvxqs	1252	56	function	function	NN
cord-296347-fanlvxqs	1252	57	of	of	IN
cord-296347-fanlvxqs	1252	58	proteasomes	proteasomes	NNP
cord-296347-fanlvxqs	1252	59	and	and	CC
cord-296347-fanlvxqs	1252	60	the	the	DT
cord-296347-fanlvxqs	1252	61	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1252	62	-	-	HYPH
cord-296347-fanlvxqs	1252	63	conjugating	conjugate	VBG
cord-296347-fanlvxqs	1252	64	pathway	pathway	NN
cord-296347-fanlvxqs	1252	65	Membrane	membrane	NN
cord-296347-fanlvxqs	1252	66	-	-	HYPH
cord-296347-fanlvxqs	1252	67	bound	bind	VBN
cord-296347-fanlvxqs	1252	68	Ubx2	Ubx2	NNP
cord-296347-fanlvxqs	1252	69	recruits	recruit	VBZ
cord-296347-fanlvxqs	1252	70	Cdc48	Cdc48	NNP
cord-296347-fanlvxqs	1252	71	to	to	TO
cord-296347-fanlvxqs	1252	72	ubiquitin	ubiquitin	VB
cord-296347-fanlvxqs	1252	73	ligases	ligase	NNS
cord-296347-fanlvxqs	1252	74	and	and	CC
cord-296347-fanlvxqs	1252	75	their	-PRON-	PRP$
cord-296347-fanlvxqs	1252	76	substrates	substrate	NNS
cord-296347-fanlvxqs	1252	77	to	to	TO
cord-296347-fanlvxqs	1252	78	ensure	ensure	VB
cord-296347-fanlvxqs	1252	79	efficient	efficient	JJ
cord-296347-fanlvxqs	1252	80	ER	er	NN
cord-296347-fanlvxqs	1252	81	-	-	HYPH
cord-296347-fanlvxqs	1252	82	associated	associate	VBN
cord-296347-fanlvxqs	1252	83	protein	protein	NN
cord-296347-fanlvxqs	1252	84	degradation	degradation	NN
cord-296347-fanlvxqs	1252	85	Suppression	suppression	NN
cord-296347-fanlvxqs	1252	86	of	of	IN
cord-296347-fanlvxqs	1252	87	major	major	JJ
cord-296347-fanlvxqs	1252	88	histocompatibility	histocompatibility	NN
cord-296347-fanlvxqs	1252	89	complex	complex	JJ
cord-296347-fanlvxqs	1252	90	class	class	NN
cord-296347-fanlvxqs	1253	1	I	-PRON-	PRP
cord-296347-fanlvxqs	1253	2	and	and	CC
cord-296347-fanlvxqs	1253	3	class	class	NN
cord-296347-fanlvxqs	1253	4	II	II	NNP
cord-296347-fanlvxqs	1253	5	gene	gene	NN
cord-296347-fanlvxqs	1253	6	expression	expression	NN
cord-296347-fanlvxqs	1253	7	in	in	IN
cord-296347-fanlvxqs	1253	8	Listeria	Listeria	NNP
cord-296347-fanlvxqs	1253	9	monocytogenes	monocytogenes	NN
cord-296347-fanlvxqs	1253	10	-	-	HYPH
cord-296347-fanlvxqs	1253	11	infected	infect	VBN
cord-296347-fanlvxqs	1253	12	murine	murine	JJ
cord-296347-fanlvxqs	1253	13	macrophages	macrophage	NNS
cord-296347-fanlvxqs	1253	14	Insights	insight	NNS
cord-296347-fanlvxqs	1253	15	into	into	IN
cord-296347-fanlvxqs	1253	16	SCF	scf	NN
cord-296347-fanlvxqs	1253	17	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1253	18	ligases	ligase	NNS
cord-296347-fanlvxqs	1253	19	from	from	IN
cord-296347-fanlvxqs	1253	20	the	the	DT
cord-296347-fanlvxqs	1253	21	structure	structure	NN
cord-296347-fanlvxqs	1253	22	of	of	IN
cord-296347-fanlvxqs	1253	23	the	the	DT
cord-296347-fanlvxqs	1253	24	Skp1-Skp2	skp1-skp2	NN
cord-296347-fanlvxqs	1253	25	complex	complex	NN
cord-296347-fanlvxqs	1254	1	The	the	DT
cord-296347-fanlvxqs	1254	2	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1254	3	-	-	HYPH
cord-296347-fanlvxqs	1254	4	domain	domain	NN
cord-296347-fanlvxqs	1254	5	protein	protein	NN
cord-296347-fanlvxqs	1254	6	HERP	HERP	NNP
cord-296347-fanlvxqs	1254	7	forms	form	VBZ
cord-296347-fanlvxqs	1254	8	a	a	DT
cord-296347-fanlvxqs	1254	9	complex	complex	NN
cord-296347-fanlvxqs	1254	10	with	with	IN
cord-296347-fanlvxqs	1254	11	components	component	NNS
cord-296347-fanlvxqs	1254	12	of	of	IN
cord-296347-fanlvxqs	1254	13	the	the	DT
cord-296347-fanlvxqs	1254	14	endoplasmic	endoplasmic	NN
cord-296347-fanlvxqs	1254	15	reticulum	reticulum	NN
cord-296347-fanlvxqs	1254	16	associated	associate	VBD
cord-296347-fanlvxqs	1254	17	degradation	degradation	NN
cord-296347-fanlvxqs	1254	18	pathway	pathway	NN
cord-296347-fanlvxqs	1254	19	A	a	DT
cord-296347-fanlvxqs	1254	20	superfamily	superfamily	NN
cord-296347-fanlvxqs	1254	21	of	of	IN
cord-296347-fanlvxqs	1254	22	protein	protein	NN
cord-296347-fanlvxqs	1254	23	tags	tag	NNS
cord-296347-fanlvxqs	1254	24	:	:	:
cord-296347-fanlvxqs	1254	25	Ubiquitin	Ubiquitin	NNP
cord-296347-fanlvxqs	1254	26	,	,	,
cord-296347-fanlvxqs	1254	27	SUMO	SUMO	NNP
cord-296347-fanlvxqs	1254	28	and	and	CC
cord-296347-fanlvxqs	1254	29	related	related	JJ
cord-296347-fanlvxqs	1254	30	modifiers	modifier	NNS
cord-296347-fanlvxqs	1254	31	Targeting	target	VBG
cord-296347-fanlvxqs	1254	32	of	of	IN
cord-296347-fanlvxqs	1254	33	hepatitis	hepatitis	NN
cord-296347-fanlvxqs	1254	34	C	C	NNP
cord-296347-fanlvxqs	1254	35	virus	virus	NN
cord-296347-fanlvxqs	1254	36	core	core	NN
cord-296347-fanlvxqs	1254	37	protein	protein	NN
cord-296347-fanlvxqs	1254	38	to	to	IN
cord-296347-fanlvxqs	1254	39	mitochondria	mitochondrion	NNS
cord-296347-fanlvxqs	1254	40	through	through	IN
cord-296347-fanlvxqs	1254	41	a	a	DT
cord-296347-fanlvxqs	1254	42	novel	novel	JJ
cord-296347-fanlvxqs	1254	43	C	c	NN
cord-296347-fanlvxqs	1254	44	-	-	HYPH
cord-296347-fanlvxqs	1254	45	terminal	terminal	NN
cord-296347-fanlvxqs	1254	46	localization	localization	NN
cord-296347-fanlvxqs	1254	47	motif	motif	NN
cord-296347-fanlvxqs	1255	1	The	the	DT
cord-296347-fanlvxqs	1255	2	26S	26S	NNP
cord-296347-fanlvxqs	1255	3	proteasome	proteasome	NN
cord-296347-fanlvxqs	1255	4	:	:	:
cord-296347-fanlvxqs	1256	1	A	a	DT
cord-296347-fanlvxqs	1256	2	dynamic	dynamic	JJ
cord-296347-fanlvxqs	1256	3	structure	structure	NN
cord-296347-fanlvxqs	1256	4	Notch	notch	NN
cord-296347-fanlvxqs	1256	5	and	and	CC
cord-296347-fanlvxqs	1256	6	Presenilin	Presenilin	NNP
cord-296347-fanlvxqs	1256	7	:	:	:
cord-296347-fanlvxqs	1257	1	Regulated	regulated	JJ
cord-296347-fanlvxqs	1257	2	intramembrane	intramembrane	NNP
cord-296347-fanlvxqs	1257	3	proteolysis	proteolysis	NN
cord-296347-fanlvxqs	1257	4	links	links	NNP
cord-296347-fanlvxqs	1257	5	development	development	NN
cord-296347-fanlvxqs	1257	6	and	and	CC
cord-296347-fanlvxqs	1257	7	degeneration	degeneration	NN
cord-296347-fanlvxqs	1257	8	Tumor	tumor	NN
cord-296347-fanlvxqs	1257	9	viruses	virus	NNS
cord-296347-fanlvxqs	1257	10	and	and	CC
cord-296347-fanlvxqs	1257	11	cell	cell	NN
cord-296347-fanlvxqs	1257	12	signaling	signal	VBG
cord-296347-fanlvxqs	1257	13	pathways	pathway	NNS
cord-296347-fanlvxqs	1257	14	:	:	:
cord-296347-fanlvxqs	1257	15	Deubiquitination	deubiquitination	NN
cord-296347-fanlvxqs	1257	16	versus	versus	IN
cord-296347-fanlvxqs	1257	17	ubiquitination	ubiquitination	NN
cord-296347-fanlvxqs	1257	18	Targeting	targeting	NN
cord-296347-fanlvxqs	1257	19	of	of	IN
cord-296347-fanlvxqs	1257	20	host	host	NN
cord-296347-fanlvxqs	1257	21	-	-	HYPH
cord-296347-fanlvxqs	1257	22	cell	cell	NN
cord-296347-fanlvxqs	1257	23	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1257	24	pathways	pathway	NNS
cord-296347-fanlvxqs	1257	25	by	by	IN
cord-296347-fanlvxqs	1257	26	viruses	virus	NNS
cord-296347-fanlvxqs	1257	27	XBP1	XBP1	NNP
cord-296347-fanlvxqs	1257	28	,	,	,
cord-296347-fanlvxqs	1257	29	downstream	downstream	RB
cord-296347-fanlvxqs	1257	30	of	of	IN
cord-296347-fanlvxqs	1257	31	Blimp-1	Blimp-1	NNP
cord-296347-fanlvxqs	1257	32	,	,	,
cord-296347-fanlvxqs	1257	33	expands	expand	VBZ
cord-296347-fanlvxqs	1257	34	the	the	DT
cord-296347-fanlvxqs	1257	35	secretory	secretory	JJ
cord-296347-fanlvxqs	1257	36	apparatus	apparatus	NN
cord-296347-fanlvxqs	1257	37	and	and	CC
cord-296347-fanlvxqs	1257	38	other	other	JJ
cord-296347-fanlvxqs	1257	39	organelles	organelle	NNS
cord-296347-fanlvxqs	1257	40	,	,	,
cord-296347-fanlvxqs	1257	41	and	and	CC
cord-296347-fanlvxqs	1257	42	increases	increase	VBZ
cord-296347-fanlvxqs	1257	43	protein	protein	NN
cord-296347-fanlvxqs	1257	44	synthesis	synthesis	NN
cord-296347-fanlvxqs	1257	45	in	in	IN
cord-296347-fanlvxqs	1257	46	plasma	plasma	NN
cord-296347-fanlvxqs	1257	47	cell	cell	NN
cord-296347-fanlvxqs	1257	48	differentiation	differentiation	NN
cord-296347-fanlvxqs	1258	1	The	the	DT
cord-296347-fanlvxqs	1258	2	pathway	pathway	NN
cord-296347-fanlvxqs	1258	3	of	of	IN
cord-296347-fanlvxqs	1258	4	US11-dependent	us11-dependent	CD
cord-296347-fanlvxqs	1258	5	degradation	degradation	NN
cord-296347-fanlvxqs	1258	6	of	of	IN
cord-296347-fanlvxqs	1258	7	MHC	MHC	NNP
cord-296347-fanlvxqs	1258	8	class	class	NN
cord-296347-fanlvxqs	1259	1	I	-PRON-	PRP
cord-296347-fanlvxqs	1259	2	heavy	heavy	JJ
cord-296347-fanlvxqs	1259	3	chains	chain	NNS
cord-296347-fanlvxqs	1259	4	involves	involve	VBZ
cord-296347-fanlvxqs	1259	5	a	a	DT
cord-296347-fanlvxqs	1259	6	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1259	7	-	-	HYPH
cord-296347-fanlvxqs	1259	8	conjugated	conjugate	VBN
cord-296347-fanlvxqs	1259	9	intermediate	intermediate	JJ
cord-296347-fanlvxqs	1259	10	PIAS	pias	NN
cord-296347-fanlvxqs	1259	11	proteins	protein	NNS
cord-296347-fanlvxqs	1259	12	and	and	CC
cord-296347-fanlvxqs	1259	13	transcriptional	transcriptional	JJ
cord-296347-fanlvxqs	1259	14	regulation	regulation	NN
cord-296347-fanlvxqs	1259	15	-	-	HYPH
cord-296347-fanlvxqs	1259	16	more	more	JJR
cord-296347-fanlvxqs	1259	17	than	than	IN
cord-296347-fanlvxqs	1259	18	just	just	RB
cord-296347-fanlvxqs	1259	19	SUMO	SUMO	NNP
cord-296347-fanlvxqs	1259	20	E3	e3	NN
cord-296347-fanlvxqs	1259	21	ligases	ligase	NNS
cord-296347-fanlvxqs	1259	22	?	?	.
cord-296347-fanlvxqs	1260	1	All	all	PDT
cord-296347-fanlvxqs	1260	2	the	the	DT
cord-296347-fanlvxqs	1260	3	peptides	peptide	NNS
cord-296347-fanlvxqs	1260	4	that	that	WDT
cord-296347-fanlvxqs	1260	5	fit	fit	VBP
cord-296347-fanlvxqs	1260	6	:	:	:
cord-296347-fanlvxqs	1261	1	The	the	DT
cord-296347-fanlvxqs	1261	2	beginning	beginning	NN
cord-296347-fanlvxqs	1261	3	,	,	,
cord-296347-fanlvxqs	1261	4	the	the	DT
cord-296347-fanlvxqs	1261	5	middle	middle	NN
cord-296347-fanlvxqs	1261	6	,	,	,
cord-296347-fanlvxqs	1261	7	and	and	CC
cord-296347-fanlvxqs	1261	8	the	the	DT
cord-296347-fanlvxqs	1261	9	end	end	NN
cord-296347-fanlvxqs	1261	10	of	of	IN
cord-296347-fanlvxqs	1261	11	the	the	DT
cord-296347-fanlvxqs	1261	12	MHC	MHC	NNP
cord-296347-fanlvxqs	1261	13	class	class	NN
cord-296347-fanlvxqs	1261	14	I	-PRON-	PRP
cord-296347-fanlvxqs	1261	15	antigen	antigen	NN
cord-296347-fanlvxqs	1261	16	-	-	HYPH
cord-296347-fanlvxqs	1261	17	processing	process	VBG
cord-296347-fanlvxqs	1261	18	pathway	pathway	NN
cord-296347-fanlvxqs	1261	19	Priming	Priming	NNP
cord-296347-fanlvxqs	1261	20	of	of	IN
cord-296347-fanlvxqs	1261	21	T	t	NN
cord-296347-fanlvxqs	1261	22	cells	cell	NNS
cord-296347-fanlvxqs	1261	23	by	by	IN
cord-296347-fanlvxqs	1261	24	exogenous	exogenous	JJ
cord-296347-fanlvxqs	1261	25	antigen	antigen	NN
cord-296347-fanlvxqs	1261	26	cross	cross	NN
cord-296347-fanlvxqs	1261	27	-	-	VBN
cord-296347-fanlvxqs	1261	28	presented	present	VBN
cord-296347-fanlvxqs	1261	29	on	on	IN
cord-296347-fanlvxqs	1261	30	MHC	MHC	NNP
cord-296347-fanlvxqs	1261	31	class	class	NN
cord-296347-fanlvxqs	1262	1	I	-PRON-	PRP
cord-296347-fanlvxqs	1262	2	molecules	molecule	VBZ
cord-296347-fanlvxqs	1262	3	Glycoprotein	Glycoprotein	NNP
cord-296347-fanlvxqs	1262	4	B	B	NNP
cord-296347-fanlvxqs	1262	5	from	from	IN
cord-296347-fanlvxqs	1262	6	strain	strain	NN
cord-296347-fanlvxqs	1262	7	17	17	CD
cord-296347-fanlvxqs	1262	8	of	of	IN
cord-296347-fanlvxqs	1262	9	herpes	herpes	NNP
cord-296347-fanlvxqs	1262	10	simplex	simplex	NNP
cord-296347-fanlvxqs	1262	11	virus	virus	NN
cord-296347-fanlvxqs	1262	12	type	type	NN
cord-296347-fanlvxqs	1263	1	I	-PRON-	PRP
cord-296347-fanlvxqs	1263	2	contains	contain	VBZ
cord-296347-fanlvxqs	1263	3	an	an	DT
cord-296347-fanlvxqs	1263	4	invariant	invariant	JJ
cord-296347-fanlvxqs	1263	5	chain	chain	NN
cord-296347-fanlvxqs	1263	6	homologous	homologous	JJ
cord-296347-fanlvxqs	1263	7	sequence	sequence	NN
cord-296347-fanlvxqs	1263	8	that	that	WDT
cord-296347-fanlvxqs	1263	9	binds	bind	VBZ
cord-296347-fanlvxqs	1263	10	to	to	IN
cord-296347-fanlvxqs	1263	11	MHC	MHC	NNP
cord-296347-fanlvxqs	1263	12	class	class	NN
cord-296347-fanlvxqs	1263	13	II	II	NNP
cord-296347-fanlvxqs	1263	14	molecules	molecule	NNS
cord-296347-fanlvxqs	1263	15	Gamma	Gamma	NNP
cord-296347-fanlvxqs	1263	16	-	-	HYPH
cord-296347-fanlvxqs	1263	17	secretase	secretase	NNP
cord-296347-fanlvxqs	1263	18	,	,	,
cord-296347-fanlvxqs	1263	19	Notch	Notch	NNP
cord-296347-fanlvxqs	1263	20	,	,	,
cord-296347-fanlvxqs	1263	21	Abeta	Abeta	NNP
cord-296347-fanlvxqs	1263	22	and	and	CC
cord-296347-fanlvxqs	1263	23	Alzheimer	Alzheimer	NNP
cord-296347-fanlvxqs	1263	24	's	's	POS
cord-296347-fanlvxqs	1263	25	disease	disease	NN
cord-296347-fanlvxqs	1263	26	:	:	:
cord-296347-fanlvxqs	1263	27	Where	where	WRB
cord-296347-fanlvxqs	1263	28	do	do	VBP
cord-296347-fanlvxqs	1263	29	the	the	DT
cord-296347-fanlvxqs	1263	30	presenilins	presenilin	NNS
cord-296347-fanlvxqs	1263	31	fit	fit	VB
cord-296347-fanlvxqs	1263	32	in	in	RP
cord-296347-fanlvxqs	1263	33	?	?	.
cord-296347-fanlvxqs	1264	1	Receptor	receptor	NN
cord-296347-fanlvxqs	1264	2	binding	binding	NN
cord-296347-fanlvxqs	1264	3	and	and	CC
cord-296347-fanlvxqs	1264	4	membrane	membrane	NN
cord-296347-fanlvxqs	1264	5	fusion	fusion	NN
cord-296347-fanlvxqs	1264	6	in	in	IN
cord-296347-fanlvxqs	1264	7	virus	virus	NN
cord-296347-fanlvxqs	1264	8	entry	entry	NN
cord-296347-fanlvxqs	1264	9	:	:	:
cord-296347-fanlvxqs	1265	1	The	the	DT
cord-296347-fanlvxqs	1265	2	influenza	influenza	NN
cord-296347-fanlvxqs	1265	3	hemagglutinin	hemagglutinin	NN
cord-296347-fanlvxqs	1265	4	Type	type	NN
cord-296347-fanlvxqs	1265	5	I	-PRON-	PRP
cord-296347-fanlvxqs	1265	6	interferons	interferon	NNS
cord-296347-fanlvxqs	1265	7	and	and	CC
cord-296347-fanlvxqs	1265	8	the	the	DT
cord-296347-fanlvxqs	1265	9	innate	innate	JJ
cord-296347-fanlvxqs	1265	10	immune	immune	JJ
cord-296347-fanlvxqs	1265	11	response	response	NN
cord-296347-fanlvxqs	1265	12	-	-	HYPH
cord-296347-fanlvxqs	1265	13	more	more	JJR
cord-296347-fanlvxqs	1265	14	than	than	IN
cord-296347-fanlvxqs	1265	15	just	just	RB
cord-296347-fanlvxqs	1265	16	antiviral	antiviral	JJ
cord-296347-fanlvxqs	1265	17	cytokines	cytokine	NNS
cord-296347-fanlvxqs	1265	18	Regulated	regulate	VBD
cord-296347-fanlvxqs	1265	19	SUMOylation	sumoylation	NN
cord-296347-fanlvxqs	1265	20	and	and	CC
cord-296347-fanlvxqs	1265	21	ubiquitination	ubiquitination	NN
cord-296347-fanlvxqs	1265	22	of	of	IN
cord-296347-fanlvxqs	1265	23	DdMEK1	ddmek1	NN
cord-296347-fanlvxqs	1265	24	is	be	VBZ
cord-296347-fanlvxqs	1265	25	required	require	VBN
cord-296347-fanlvxqs	1265	26	for	for	IN
cord-296347-fanlvxqs	1265	27	proper	proper	JJ
cord-296347-fanlvxqs	1265	28	chemotaxis	chemotaxis	NN
cord-296347-fanlvxqs	1265	29	Deubiquitinating	deubiquitinating	NN
cord-296347-fanlvxqs	1265	30	enzymes	enzyme	NNS
cord-296347-fanlvxqs	1265	31	:	:	:
cord-296347-fanlvxqs	1265	32	Their	-PRON-	PRP$
cord-296347-fanlvxqs	1265	33	functions	function	NNS
cord-296347-fanlvxqs	1265	34	and	and	CC
cord-296347-fanlvxqs	1265	35	substrate	substrate	NN
cord-296347-fanlvxqs	1265	36	specificity	specificity	NN
cord-296347-fanlvxqs	1266	1	HIV-1	HIV-1	NNP
cord-296347-fanlvxqs	1266	2	Nef	Nef	NNP
cord-296347-fanlvxqs	1266	3	-	-	HYPH
cord-296347-fanlvxqs	1266	4	induced	induce	VBN
cord-296347-fanlvxqs	1266	5	upregulation	upregulation	NN
cord-296347-fanlvxqs	1266	6	of	of	IN
cord-296347-fanlvxqs	1266	7	DC	DC	NNP
cord-296347-fanlvxqs	1266	8	-	-	HYPH
cord-296347-fanlvxqs	1266	9	SIGN	sign	NN
cord-296347-fanlvxqs	1266	10	in	in	IN
cord-296347-fanlvxqs	1266	11	dendritic	dendritic	JJ
cord-296347-fanlvxqs	1266	12	cells	cell	NNS
cord-296347-fanlvxqs	1266	13	promotes	promote	VBZ
cord-296347-fanlvxqs	1266	14	lymphocyte	lymphocyte	NN
cord-296347-fanlvxqs	1266	15	clustering	clustering	NN
cord-296347-fanlvxqs	1266	16	and	and	CC
cord-296347-fanlvxqs	1266	17	viral	viral	JJ
cord-296347-fanlvxqs	1266	18	spread	spread	NN
cord-296347-fanlvxqs	1266	19	Gp78	gp78	NN
cord-296347-fanlvxqs	1266	20	,	,	,
cord-296347-fanlvxqs	1266	21	a	a	DT
cord-296347-fanlvxqs	1266	22	membrane	membrane	NN
cord-296347-fanlvxqs	1266	23	-	-	HYPH
cord-296347-fanlvxqs	1266	24	anchored	anchor	VBN
cord-296347-fanlvxqs	1266	25	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1266	26	ligase	ligase	NN
cord-296347-fanlvxqs	1266	27	,	,	,
cord-296347-fanlvxqs	1266	28	associates	associate	NNS
cord-296347-fanlvxqs	1266	29	with	with	IN
cord-296347-fanlvxqs	1266	30	Insig-1	Insig-1	NNP
cord-296347-fanlvxqs	1266	31	and	and	CC
cord-296347-fanlvxqs	1266	32	couples	couple	NNS
cord-296347-fanlvxqs	1266	33	sterol	sterol	NN
cord-296347-fanlvxqs	1266	34	-	-	HYPH
cord-296347-fanlvxqs	1266	35	regulated	regulate	VBN
cord-296347-fanlvxqs	1266	36	ubiquitination	ubiquitination	NN
cord-296347-fanlvxqs	1266	37	to	to	IN
cord-296347-fanlvxqs	1266	38	degradation	degradation	NN
cord-296347-fanlvxqs	1266	39	of	of	IN
cord-296347-fanlvxqs	1266	40	HMG	HMG	NNP
cord-296347-fanlvxqs	1266	41	CoA	coa	NN
cord-296347-fanlvxqs	1266	42	reductase	reductase	NN
cord-296347-fanlvxqs	1266	43	Dynamics	Dynamics	NNP
cord-296347-fanlvxqs	1266	44	of	of	IN
cord-296347-fanlvxqs	1266	45	virus	virus	NN
cord-296347-fanlvxqs	1266	46	-	-	HYPH
cord-296347-fanlvxqs	1266	47	host	host	NN
cord-296347-fanlvxqs	1266	48	interplay	interplay	NN
cord-296347-fanlvxqs	1266	49	in	in	IN
cord-296347-fanlvxqs	1266	50	HIV-1	HIV-1	NNP
cord-296347-fanlvxqs	1266	51	replication	replication	NN
cord-296347-fanlvxqs	1267	1	The	the	DT
cord-296347-fanlvxqs	1267	2	extracellular	extracellular	JJ
cord-296347-fanlvxqs	1267	3	domain	domain	NN
cord-296347-fanlvxqs	1267	4	of	of	IN
cord-296347-fanlvxqs	1267	5	the	the	DT
cord-296347-fanlvxqs	1267	6	Epstein	Epstein	NNP
cord-296347-fanlvxqs	1267	7	-	-	HYPH
cord-296347-fanlvxqs	1267	8	Barr	Barr	NNP
cord-296347-fanlvxqs	1267	9	virus	virus	NN
cord-296347-fanlvxqs	1268	1	BZLF2	BZLF2	NNP
cord-296347-fanlvxqs	1268	2	protein	protein	NN
cord-296347-fanlvxqs	1268	3	binds	bind	VBZ
cord-296347-fanlvxqs	1268	4	the	the	DT
cord-296347-fanlvxqs	1268	5	HLA	HLA	NNP
cord-296347-fanlvxqs	1268	6	-	-	HYPH
cord-296347-fanlvxqs	1268	7	DR	DR	NNP
cord-296347-fanlvxqs	1268	8	beta	beta	NN
cord-296347-fanlvxqs	1268	9	chain	chain	NN
cord-296347-fanlvxqs	1268	10	and	and	CC
cord-296347-fanlvxqs	1268	11	inhibits	inhibit	VBZ
cord-296347-fanlvxqs	1268	12	antigen	antigen	NN
cord-296347-fanlvxqs	1268	13	presentation	presentation	NN
cord-296347-fanlvxqs	1268	14	Modulation	modulation	NN
cord-296347-fanlvxqs	1268	15	of	of	IN
cord-296347-fanlvxqs	1268	16	gamma	gamma	NN
cord-296347-fanlvxqs	1268	17	interferon	interferon	NN
cord-296347-fanlvxqs	1268	18	-	-	HYPH
cord-296347-fanlvxqs	1268	19	induced	induce	VBN
cord-296347-fanlvxqs	1268	20	major	major	JJ
cord-296347-fanlvxqs	1268	21	histocompatibility	histocompatibility	NN
cord-296347-fanlvxqs	1268	22	complex	complex	JJ
cord-296347-fanlvxqs	1268	23	class	class	NN
cord-296347-fanlvxqs	1268	24	II	II	NNP
cord-296347-fanlvxqs	1268	25	gene	gene	NN
cord-296347-fanlvxqs	1268	26	expression	expression	NN
cord-296347-fanlvxqs	1268	27	by	by	IN
cord-296347-fanlvxqs	1268	28	Porphyromonas	Porphyromonas	NNP
cord-296347-fanlvxqs	1268	29	gingivalis	gingivalis	NNP
cord-296347-fanlvxqs	1268	30	membrane	membrane	NN
cord-296347-fanlvxqs	1268	31	vesicles	vesicle	NNS
cord-296347-fanlvxqs	1268	32	MHC	MHC	NNP
cord-296347-fanlvxqs	1268	33	class	class	NN
cord-296347-fanlvxqs	1268	34	II	II	NNP
cord-296347-fanlvxqs	1268	35	compartment	compartment	NN
cord-296347-fanlvxqs	1268	36	subtypes	subtype	NNS
cord-296347-fanlvxqs	1268	37	:	:	:
cord-296347-fanlvxqs	1269	1	Structure	structure	NN
cord-296347-fanlvxqs	1269	2	and	and	CC
cord-296347-fanlvxqs	1269	3	function	function	VB
cord-296347-fanlvxqs	1269	4	Inhibition	inhibition	NN
cord-296347-fanlvxqs	1269	5	of	of	IN
cord-296347-fanlvxqs	1269	6	MHC	MHC	NNP
cord-296347-fanlvxqs	1269	7	class	class	NN
cord-296347-fanlvxqs	1269	8	Irestricted	Irestricted	NNP
cord-296347-fanlvxqs	1269	9	antigen	antigen	NN
cord-296347-fanlvxqs	1269	10	presentation	presentation	NN
cord-296347-fanlvxqs	1269	11	by	by	IN
cord-296347-fanlvxqs	1269	12	gamma	gamma	NN
cord-296347-fanlvxqs	1269	13	2-herpesviruses	2-herpesviruses	CD
cord-296347-fanlvxqs	1269	14	Dendritic	dendritic	JJ
cord-296347-fanlvxqs	1269	15	cells	cell	NNS
cord-296347-fanlvxqs	1269	16	:	:	:
cord-296347-fanlvxqs	1269	17	Immunological	immunological	JJ
cord-296347-fanlvxqs	1269	18	sentinels	sentinel	NNS
cord-296347-fanlvxqs	1269	19	with	with	IN
cord-296347-fanlvxqs	1269	20	a	a	DT
cord-296347-fanlvxqs	1269	21	central	central	JJ
cord-296347-fanlvxqs	1269	22	role	role	NN
cord-296347-fanlvxqs	1269	23	in	in	IN
cord-296347-fanlvxqs	1269	24	health	health	NN
cord-296347-fanlvxqs	1269	25	and	and	CC
cord-296347-fanlvxqs	1269	26	disease	disease	NN
cord-296347-fanlvxqs	1269	27	Interferon	interferon	NN
cord-296347-fanlvxqs	1269	28	-	-	HYPH
cord-296347-fanlvxqs	1269	29	gamma	gamma	NN
cord-296347-fanlvxqs	1269	30	,	,	,
cord-296347-fanlvxqs	1269	31	the	the	DT
cord-296347-fanlvxqs	1269	32	functional	functional	JJ
cord-296347-fanlvxqs	1269	33	plasticity	plasticity	NN
cord-296347-fanlvxqs	1269	34	of	of	IN
cord-296347-fanlvxqs	1269	35	the	the	DT
cord-296347-fanlvxqs	1269	36	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1269	37	-	-	HYPH
cord-296347-fanlvxqs	1269	38	proteasome	proteasome	VBN
cord-296347-fanlvxqs	1269	39	system	system	NN
cord-296347-fanlvxqs	1269	40	,	,	,
cord-296347-fanlvxqs	1269	41	and	and	CC
cord-296347-fanlvxqs	1269	42	MHC	MHC	NNP
cord-296347-fanlvxqs	1269	43	class	class	NN
cord-296347-fanlvxqs	1269	44	I	-PRON-	PRP
cord-296347-fanlvxqs	1269	45	antigen	antigen	NN
cord-296347-fanlvxqs	1269	46	processing	process	VBG
cord-296347-fanlvxqs	1269	47	The	the	DT
cord-296347-fanlvxqs	1269	48	human	human	JJ
cord-296347-fanlvxqs	1269	49	endosomal	endosomal	NNP
cord-296347-fanlvxqs	1269	50	sorting	sort	VBG
cord-296347-fanlvxqs	1269	51	complex	complex	NN
cord-296347-fanlvxqs	1269	52	required	require	VBN
cord-296347-fanlvxqs	1269	53	for	for	IN
cord-296347-fanlvxqs	1269	54	transport	transport	NN
cord-296347-fanlvxqs	1269	55	(	(	-LRB-
cord-296347-fanlvxqs	1269	56	ESCRT	ESCRT	NNP
cord-296347-fanlvxqs	1269	57	-	-	HYPH
cord-296347-fanlvxqs	1269	58	I	I	NNP
cord-296347-fanlvxqs	1269	59	)	)	-RRB-
cord-296347-fanlvxqs	1269	60	and	and	CC
cord-296347-fanlvxqs	1269	61	its	-PRON-	PRP$
cord-296347-fanlvxqs	1269	62	role	role	NN
cord-296347-fanlvxqs	1269	63	in	in	IN
cord-296347-fanlvxqs	1269	64	HIV-1	HIV-1	NNP
cord-296347-fanlvxqs	1269	65	budding	bud	VBG
cord-296347-fanlvxqs	1269	66	HIV-1	HIV-1	NNP
cord-296347-fanlvxqs	1269	67	Nef	Nef	NNP
cord-296347-fanlvxqs	1269	68	impairs	impair	VBZ
cord-296347-fanlvxqs	1269	69	MHC	MHC	NNP
cord-296347-fanlvxqs	1269	70	class	class	NN
cord-296347-fanlvxqs	1269	71	II	II	NNP
cord-296347-fanlvxqs	1269	72	antigen	antigen	NN
cord-296347-fanlvxqs	1269	73	presentation	presentation	NN
cord-296347-fanlvxqs	1269	74	and	and	CC
cord-296347-fanlvxqs	1269	75	surface	surface	NN
cord-296347-fanlvxqs	1269	76	expression	expression	NN
cord-296347-fanlvxqs	1269	77	Human	human	JJ
cord-296347-fanlvxqs	1269	78	immunodeficiency	immunodeficiency	NN
cord-296347-fanlvxqs	1269	79	virus-1	virus-1	NN
cord-296347-fanlvxqs	1269	80	Nef	Nef	NNP
cord-296347-fanlvxqs	1269	81	expression	expression	NN
cord-296347-fanlvxqs	1269	82	induces	induce	VBZ
cord-296347-fanlvxqs	1269	83	intracellular	intracellular	JJ
cord-296347-fanlvxqs	1269	84	accumulation	accumulation	NN
cord-296347-fanlvxqs	1269	85	of	of	IN
cord-296347-fanlvxqs	1269	86	multivesicular	multivesicular	NNP
cord-296347-fanlvxqs	1269	87	bodies	body	NNS
cord-296347-fanlvxqs	1269	88	and	and	CC
cord-296347-fanlvxqs	1269	89	major	major	JJ
cord-296347-fanlvxqs	1269	90	histocompatibility	histocompatibility	NN
cord-296347-fanlvxqs	1269	91	complex	complex	JJ
cord-296347-fanlvxqs	1269	92	class	class	NN
cord-296347-fanlvxqs	1269	93	II	II	NNP
cord-296347-fanlvxqs	1269	94	complexes	complex	NNS
cord-296347-fanlvxqs	1269	95	:	:	:
cord-296347-fanlvxqs	1270	1	Potential	potential	JJ
cord-296347-fanlvxqs	1270	2	role	role	NN
cord-296347-fanlvxqs	1270	3	of	of	IN
cord-296347-fanlvxqs	1270	4	phosphatidylinositol	phosphatidylinositol	JJ
cord-296347-fanlvxqs	1270	5	3-kinase	3-kinase	CD
cord-296347-fanlvxqs	1270	6	Molecular	molecular	JJ
cord-296347-fanlvxqs	1270	7	determinants	determinant	NNS
cord-296347-fanlvxqs	1270	8	for	for	IN
cord-296347-fanlvxqs	1270	9	subcellular	subcellular	JJ
cord-296347-fanlvxqs	1270	10	localization	localization	NN
cord-296347-fanlvxqs	1270	11	of	of	IN
cord-296347-fanlvxqs	1270	12	hepatitis	hepatitis	NN
cord-296347-fanlvxqs	1270	13	C	C	NNP
cord-296347-fanlvxqs	1270	14	virus	virus	NN
cord-296347-fanlvxqs	1270	15	core	core	NN
cord-296347-fanlvxqs	1270	16	protein	protein	NN
cord-296347-fanlvxqs	1270	17	PNG1	PNG1	NNP
cord-296347-fanlvxqs	1270	18	,	,	,
cord-296347-fanlvxqs	1270	19	a	a	DT
cord-296347-fanlvxqs	1270	20	yeast	yeast	NN
cord-296347-fanlvxqs	1270	21	gene	gene	NN
cord-296347-fanlvxqs	1270	22	encoding	encode	VBG
cord-296347-fanlvxqs	1270	23	a	a	DT
cord-296347-fanlvxqs	1270	24	highly	highly	RB
cord-296347-fanlvxqs	1270	25	conserved	conserve	VBN
cord-296347-fanlvxqs	1270	26	peptide	peptide	NN
cord-296347-fanlvxqs	1270	27	:	:	:
cord-296347-fanlvxqs	1270	28	N	n	CD
cord-296347-fanlvxqs	1270	29	-	-	HYPH
cord-296347-fanlvxqs	1270	30	glycanase	glycanase	NN
cord-296347-fanlvxqs	1270	31	A	a	DT
cord-296347-fanlvxqs	1270	32	conserved	conserve	VBN
cord-296347-fanlvxqs	1270	33	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1270	34	ligase	ligase	NN
cord-296347-fanlvxqs	1270	35	of	of	IN
cord-296347-fanlvxqs	1270	36	the	the	DT
cord-296347-fanlvxqs	1270	37	nuclear	nuclear	JJ
cord-296347-fanlvxqs	1270	38	envelope	envelope	NN
cord-296347-fanlvxqs	1270	39	/	/	SYM
cord-296347-fanlvxqs	1270	40	endoplasmic	endoplasmic	NN
cord-296347-fanlvxqs	1270	41	reticulum	reticulum	NN
cord-296347-fanlvxqs	1270	42	that	that	WDT
cord-296347-fanlvxqs	1270	43	functions	function	NNS
cord-296347-fanlvxqs	1270	44	in	in	IN
cord-296347-fanlvxqs	1270	45	both	both	DT
cord-296347-fanlvxqs	1270	46	ER	er	NN
cord-296347-fanlvxqs	1270	47	-	-	HYPH
cord-296347-fanlvxqs	1270	48	associated	associate	VBN
cord-296347-fanlvxqs	1270	49	and	and	CC
cord-296347-fanlvxqs	1270	50	Matalpha2	Matalpha2	NNP
cord-296347-fanlvxqs	1270	51	repressor	repressor	NN
cord-296347-fanlvxqs	1270	52	degradation	degradation	NN
cord-296347-fanlvxqs	1270	53	Mechanism	mechanism	NN
cord-296347-fanlvxqs	1270	54	for	for	IN
cord-296347-fanlvxqs	1270	55	down	down	IN
cord-296347-fanlvxqs	1270	56	-	-	HYPH
cord-296347-fanlvxqs	1270	57	regulation	regulation	NN
cord-296347-fanlvxqs	1270	58	of	of	IN
cord-296347-fanlvxqs	1270	59	CD28	CD28	NNP
cord-296347-fanlvxqs	1270	60	by	by	IN
cord-296347-fanlvxqs	1270	61	Nef	Nef	NNP
cord-296347-fanlvxqs	1270	62	Transmembrane	Transmembrane	NNP
cord-296347-fanlvxqs	1270	63	inhibitors	inhibitor	NNS
cord-296347-fanlvxqs	1270	64	of	of	IN
cord-296347-fanlvxqs	1270	65	P	p	NN
cord-296347-fanlvxqs	1270	66	-	-	HYPH
cord-296347-fanlvxqs	1270	67	glycoprotein	glycoprotein	NN
cord-296347-fanlvxqs	1270	68	,	,	,
cord-296347-fanlvxqs	1270	69	an	an	DT
cord-296347-fanlvxqs	1270	70	ABC	ABC	NNP
cord-296347-fanlvxqs	1270	71	transporter	transporter	NN
cord-296347-fanlvxqs	1270	72	ER	er	NN
cord-296347-fanlvxqs	1270	73	-	-	HYPH
cord-296347-fanlvxqs	1270	74	golgi	golgi	NN
cord-296347-fanlvxqs	1270	75	traffic	traffic	NN
cord-296347-fanlvxqs	1270	76	is	be	VBZ
cord-296347-fanlvxqs	1270	77	a	a	DT
cord-296347-fanlvxqs	1270	78	prerequisite	prerequisite	NN
cord-296347-fanlvxqs	1270	79	for	for	IN
cord-296347-fanlvxqs	1270	80	efficient	efficient	JJ
cord-296347-fanlvxqs	1270	81	ER	ER	NNP
cord-296347-fanlvxqs	1270	82	degradation	degradation	NN
cord-296347-fanlvxqs	1271	1	The	the	DT
cord-296347-fanlvxqs	1271	2	endoplasmic	endoplasmic	NN
cord-296347-fanlvxqs	1271	3	reticulum	reticulum	NN
cord-296347-fanlvxqs	1271	4	degradation	degradation	NN
cord-296347-fanlvxqs	1271	5	pathway	pathway	NN
cord-296347-fanlvxqs	1271	6	for	for	IN
cord-296347-fanlvxqs	1271	7	mutant	mutant	JJ
cord-296347-fanlvxqs	1271	8	secretory	secretory	JJ
cord-296347-fanlvxqs	1271	9	proteins	protein	NNS
cord-296347-fanlvxqs	1272	1	alpha1-antitrypsin	alpha1-antitrypsin	NNP
cord-296347-fanlvxqs	1272	2	Z	Z	NNP
cord-296347-fanlvxqs	1272	3	and	and	CC
cord-296347-fanlvxqs	1272	4	S	S	NNP
cord-296347-fanlvxqs	1272	5	is	be	VBZ
cord-296347-fanlvxqs	1272	6	distinct	distinct	JJ
cord-296347-fanlvxqs	1272	7	from	from	IN
cord-296347-fanlvxqs	1272	8	that	that	DT
cord-296347-fanlvxqs	1272	9	for	for	IN
cord-296347-fanlvxqs	1272	10	an	an	DT
cord-296347-fanlvxqs	1272	11	unassembled	unassembled	JJ
cord-296347-fanlvxqs	1272	12	membrane	membrane	NN
cord-296347-fanlvxqs	1272	13	protein	protein	NN
cord-296347-fanlvxqs	1272	14	Cdc48	Cdc48	NNP
cord-296347-fanlvxqs	1272	15	can	can	MD
cord-296347-fanlvxqs	1272	16	distinguish	distinguish	VB
cord-296347-fanlvxqs	1272	17	between	between	IN
cord-296347-fanlvxqs	1272	18	native	native	JJ
cord-296347-fanlvxqs	1272	19	and	and	CC
cord-296347-fanlvxqs	1272	20	non	non	JJ
cord-296347-fanlvxqs	1272	21	-	-	JJ
cord-296347-fanlvxqs	1272	22	native	native	JJ
cord-296347-fanlvxqs	1272	23	proteins	protein	NNS
cord-296347-fanlvxqs	1272	24	in	in	IN
cord-296347-fanlvxqs	1272	25	the	the	DT
cord-296347-fanlvxqs	1272	26	absence	absence	NN
cord-296347-fanlvxqs	1272	27	of	of	IN
cord-296347-fanlvxqs	1272	28	cofactors	cofactor	NNS
cord-296347-fanlvxqs	1273	1	The	the	DT
cord-296347-fanlvxqs	1273	2	ISG15	isg15	NN
cord-296347-fanlvxqs	1273	3	isopeptidase	isopeptidase	IN
cord-296347-fanlvxqs	1273	4	UBP43	UBP43	NNP
cord-296347-fanlvxqs	1273	5	is	be	VBZ
cord-296347-fanlvxqs	1273	6	regulated	regulate	VBN
cord-296347-fanlvxqs	1273	7	by	by	IN
cord-296347-fanlvxqs	1273	8	proteolysis	proteolysis	NN
cord-296347-fanlvxqs	1273	9	via	via	IN
cord-296347-fanlvxqs	1273	10	the	the	DT
cord-296347-fanlvxqs	1273	11	SCFSkp2	scfskp2	NN
cord-296347-fanlvxqs	1273	12	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1273	13	ligase	ligase	NN
cord-296347-fanlvxqs	1273	14	Surface	surface	NN
cord-296347-fanlvxqs	1273	15	expression	expression	NN
cord-296347-fanlvxqs	1273	16	of	of	IN
cord-296347-fanlvxqs	1273	17	HLA	HLA	NNP
cord-296347-fanlvxqs	1273	18	-	-	HYPH
cord-296347-fanlvxqs	1273	19	E	E	NNP
cord-296347-fanlvxqs	1273	20	,	,	,
cord-296347-fanlvxqs	1273	21	an	an	DT
cord-296347-fanlvxqs	1273	22	inhibitor	inhibitor	NN
cord-296347-fanlvxqs	1273	23	of	of	IN
cord-296347-fanlvxqs	1273	24	natural	natural	JJ
cord-296347-fanlvxqs	1273	25	killer	killer	NN
cord-296347-fanlvxqs	1273	26	cells	cell	NNS
cord-296347-fanlvxqs	1273	27	,	,	,
cord-296347-fanlvxqs	1273	28	enhanced	enhance	VBN
cord-296347-fanlvxqs	1273	29	by	by	IN
cord-296347-fanlvxqs	1273	30	human	human	JJ
cord-296347-fanlvxqs	1273	31	cytomegalovirus	cytomegalovirus	NN
cord-296347-fanlvxqs	1273	32	gpUL40	gpUL40	NNP
cord-296347-fanlvxqs	1273	33	Downregulation	Downregulation	NNP
cord-296347-fanlvxqs	1273	34	of	of	IN
cord-296347-fanlvxqs	1273	35	natural	natural	JJ
cord-296347-fanlvxqs	1273	36	killer	killer	NN
cord-296347-fanlvxqs	1273	37	cell	cell	NN
cord-296347-fanlvxqs	1273	38	-	-	HYPH
cord-296347-fanlvxqs	1273	39	activating	activate	VBG
cord-296347-fanlvxqs	1273	40	ligand	ligand	NN
cord-296347-fanlvxqs	1273	41	CD155	cd155	NN
cord-296347-fanlvxqs	1273	42	by	by	IN
cord-296347-fanlvxqs	1273	43	human	human	JJ
cord-296347-fanlvxqs	1273	44	cytomegalovirus	cytomegalovirus	NN
cord-296347-fanlvxqs	1273	45	Cytomegalovirus	Cytomegalovirus	NNP
cord-296347-fanlvxqs	1273	46	US2	US2	NNP
cord-296347-fanlvxqs	1273	47	destroys	destroy	VBZ
cord-296347-fanlvxqs	1273	48	two	two	CD
cord-296347-fanlvxqs	1273	49	components	component	NNS
cord-296347-fanlvxqs	1273	50	of	of	IN
cord-296347-fanlvxqs	1273	51	the	the	DT
cord-296347-fanlvxqs	1273	52	MHC	MHC	NNP
cord-296347-fanlvxqs	1273	53	class	class	NN
cord-296347-fanlvxqs	1273	54	II	II	NNP
cord-296347-fanlvxqs	1273	55	pathway	pathway	NN
cord-296347-fanlvxqs	1273	56	,	,	,
cord-296347-fanlvxqs	1273	57	preventing	prevent	VBG
cord-296347-fanlvxqs	1273	58	recognition	recognition	NN
cord-296347-fanlvxqs	1273	59	by	by	IN
cord-296347-fanlvxqs	1273	60	CD4þ	CD4þ	NNP
cord-296347-fanlvxqs	1273	61	T	T	NNP
cord-296347-fanlvxqs	1273	62	cells	cell	NNS
cord-296347-fanlvxqs	1273	63	Viral	viral	JJ
cord-296347-fanlvxqs	1273	64	subversion	subversion	NN
cord-296347-fanlvxqs	1273	65	of	of	IN
cord-296347-fanlvxqs	1273	66	the	the	DT
cord-296347-fanlvxqs	1273	67	immune	immune	JJ
cord-296347-fanlvxqs	1273	68	system	system	NN
cord-296347-fanlvxqs	1273	69	Agrobacterium	Agrobacterium	NNP
cord-296347-fanlvxqs	1273	70	T	T	NNP
cord-296347-fanlvxqs	1273	71	-	-	HYPH
cord-296347-fanlvxqs	1273	72	DNA	dna	NN
cord-296347-fanlvxqs	1273	73	integration	integration	NN
cord-296347-fanlvxqs	1273	74	:	:	:
cord-296347-fanlvxqs	1273	75	Molecules	molecule	NNS
cord-296347-fanlvxqs	1273	76	and	and	CC
cord-296347-fanlvxqs	1273	77	models	model	NNS
cord-296347-fanlvxqs	1273	78	Involvement	Involvement	NNP
cord-296347-fanlvxqs	1273	79	of	of	IN
cord-296347-fanlvxqs	1273	80	targeted	target	VBN
cord-296347-fanlvxqs	1273	81	proteolysis	proteolysis	NN
cord-296347-fanlvxqs	1273	82	in	in	IN
cord-296347-fanlvxqs	1273	83	plant	plant	NN
cord-296347-fanlvxqs	1273	84	genetic	genetic	JJ
cord-296347-fanlvxqs	1273	85	transformation	transformation	NN
cord-296347-fanlvxqs	1273	86	by	by	IN
cord-296347-fanlvxqs	1273	87	Agrobacterium	Agrobacterium	NNP
cord-296347-fanlvxqs	1273	88	Paramyxoviruses	Paramyxoviruses	NNP
cord-296347-fanlvxqs	1273	89	SV5	SV5	NNP
cord-296347-fanlvxqs	1273	90	and	and	CC
cord-296347-fanlvxqs	1273	91	HPIV2	hpiv2	NN
cord-296347-fanlvxqs	1273	92	assemble	assemble	VB
cord-296347-fanlvxqs	1273	93	STAT	stat	NN
cord-296347-fanlvxqs	1273	94	protein	protein	NN
cord-296347-fanlvxqs	1273	95	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1273	96	ligase	ligase	NN
cord-296347-fanlvxqs	1273	97	complexes	complex	NNS
cord-296347-fanlvxqs	1273	98	from	from	IN
cord-296347-fanlvxqs	1273	99	cellular	cellular	JJ
cord-296347-fanlvxqs	1273	100	components	component	NNS
cord-296347-fanlvxqs	1273	101	Composition	composition	NN
cord-296347-fanlvxqs	1273	102	and	and	CC
cord-296347-fanlvxqs	1273	103	assembly	assembly	NN
cord-296347-fanlvxqs	1273	104	of	of	IN
cord-296347-fanlvxqs	1273	105	STAT	stat	NN
cord-296347-fanlvxqs	1273	106	-	-	HYPH
cord-296347-fanlvxqs	1273	107	targeting	target	VBG
cord-296347-fanlvxqs	1273	108	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1273	109	ligase	ligase	NN
cord-296347-fanlvxqs	1273	110	complexes	complex	NNS
cord-296347-fanlvxqs	1273	111	:	:	:
cord-296347-fanlvxqs	1273	112	Paramyxovirus	Paramyxovirus	NNP
cord-296347-fanlvxqs	1273	113	V	V	NNP
cord-296347-fanlvxqs	1273	114	protein	protein	NN
cord-296347-fanlvxqs	1273	115	carboxyl	carboxyl	NN
cord-296347-fanlvxqs	1273	116	terminus	terminus	NN
cord-296347-fanlvxqs	1273	117	is	be	VBZ
cord-296347-fanlvxqs	1273	118	an	an	DT
cord-296347-fanlvxqs	1273	119	oligomerization	oligomerization	NN
cord-296347-fanlvxqs	1273	120	domain	domain	NN
cord-296347-fanlvxqs	1273	121	STAT3	STAT3	''
cord-296347-fanlvxqs	1273	122	ubiquitylation	ubiquitylation	NN
cord-296347-fanlvxqs	1273	123	and	and	CC
cord-296347-fanlvxqs	1273	124	degradation	degradation	NN
cord-296347-fanlvxqs	1273	125	by	by	IN
cord-296347-fanlvxqs	1273	126	mumps	mumps	NN
cord-296347-fanlvxqs	1273	127	virus	virus	NN
cord-296347-fanlvxqs	1274	1	suppress	suppress	VB
cord-296347-fanlvxqs	1274	2	cytokine	cytokine	NN
cord-296347-fanlvxqs	1274	3	and	and	CC
cord-296347-fanlvxqs	1274	4	oncogene	oncogene	NN
cord-296347-fanlvxqs	1274	5	signaling	signal	VBG
cord-296347-fanlvxqs	1274	6	Cutting	cut	VBG
cord-296347-fanlvxqs	1274	7	edge	edge	NN
cord-296347-fanlvxqs	1274	8	:	:	:
cord-296347-fanlvxqs	1274	9	The	the	DT
cord-296347-fanlvxqs	1274	10	human	human	JJ
cord-296347-fanlvxqs	1274	11	cytomegalovirus	cytomegalovirus	NN
cord-296347-fanlvxqs	1274	12	UL40	UL40	NNP
cord-296347-fanlvxqs	1274	13	gene	gene	NN
cord-296347-fanlvxqs	1274	14	product	product	NN
cord-296347-fanlvxqs	1274	15	contains	contain	VBZ
cord-296347-fanlvxqs	1274	16	a	a	DT
cord-296347-fanlvxqs	1274	17	ligand	ligand	NN
cord-296347-fanlvxqs	1274	18	for	for	IN
cord-296347-fanlvxqs	1274	19	HLA	HLA	NNP
cord-296347-fanlvxqs	1274	20	-	-	HYPH
cord-296347-fanlvxqs	1274	21	E	E	NNP
cord-296347-fanlvxqs	1274	22	and	and	CC
cord-296347-fanlvxqs	1274	23	prevents	prevent	VBZ
cord-296347-fanlvxqs	1274	24	NK	NK	NNP
cord-296347-fanlvxqs	1274	25	cell	cell	NN
cord-296347-fanlvxqs	1274	26	-	-	HYPH
cord-296347-fanlvxqs	1274	27	mediated	mediate	VBN
cord-296347-fanlvxqs	1274	28	lysis	lysis	NN
cord-296347-fanlvxqs	1274	29	Differential	differential	NN
cord-296347-fanlvxqs	1274	30	processing	processing	NN
cord-296347-fanlvxqs	1274	31	of	of	IN
cord-296347-fanlvxqs	1274	32	class	class	NN
cord-296347-fanlvxqs	1274	33	-	-	HYPH
cord-296347-fanlvxqs	1274	34	I	i	NN
cord-296347-fanlvxqs	1274	35	-	-	HYPH
cord-296347-fanlvxqs	1274	36	restricted	restrict	VBN
cord-296347-fanlvxqs	1274	37	epitopes	epitope	NNS
cord-296347-fanlvxqs	1274	38	by	by	IN
cord-296347-fanlvxqs	1274	39	the	the	DT
cord-296347-fanlvxqs	1274	40	standard	standard	JJ
cord-296347-fanlvxqs	1274	41	proteasome	proteasome	NN
cord-296347-fanlvxqs	1274	42	and	and	CC
cord-296347-fanlvxqs	1274	43	the	the	DT
cord-296347-fanlvxqs	1274	44	immunoproteasome	immunoproteasome	NNP
cord-296347-fanlvxqs	1274	45	Regulated	Regulated	NNP
cord-296347-fanlvxqs	1274	46	protein	protein	NN
cord-296347-fanlvxqs	1274	47	degradation	degradation	NN
cord-296347-fanlvxqs	1275	1	Misfolded	Misfolded	NNP
cord-296347-fanlvxqs	1275	2	proteins	protein	NNS
cord-296347-fanlvxqs	1275	3	are	be	VBP
cord-296347-fanlvxqs	1275	4	sorted	sort	VBN
cord-296347-fanlvxqs	1275	5	by	by	IN
cord-296347-fanlvxqs	1275	6	a	a	DT
cord-296347-fanlvxqs	1275	7	sequential	sequential	JJ
cord-296347-fanlvxqs	1275	8	checkpoint	checkpoint	NN
cord-296347-fanlvxqs	1275	9	mechanism	mechanism	NN
cord-296347-fanlvxqs	1275	10	of	of	IN
cord-296347-fanlvxqs	1275	11	ER	ER	NNP
cord-296347-fanlvxqs	1275	12	quality	quality	NN
cord-296347-fanlvxqs	1275	13	control	control	NN
cord-296347-fanlvxqs	1276	1	Distinct	distinct	JJ
cord-296347-fanlvxqs	1276	2	retrieval	retrieval	NN
cord-296347-fanlvxqs	1276	3	and	and	CC
cord-296347-fanlvxqs	1276	4	retention	retention	NN
cord-296347-fanlvxqs	1276	5	mechanisms	mechanism	NNS
cord-296347-fanlvxqs	1276	6	are	be	VBP
cord-296347-fanlvxqs	1276	7	required	require	VBN
cord-296347-fanlvxqs	1276	8	for	for	IN
cord-296347-fanlvxqs	1276	9	the	the	DT
cord-296347-fanlvxqs	1276	10	quality	quality	NN
cord-296347-fanlvxqs	1276	11	control	control	NN
cord-296347-fanlvxqs	1276	12	of	of	IN
cord-296347-fanlvxqs	1276	13	endoplasmic	endoplasmic	NN
cord-296347-fanlvxqs	1276	14	reticulum	reticulum	NN
cord-296347-fanlvxqs	1276	15	protein	protein	NN
cord-296347-fanlvxqs	1276	16	folding	fold	VBG
cord-296347-fanlvxqs	1276	17	Proteases	Proteases	NNP
cord-296347-fanlvxqs	1276	18	involved	involve	VBN
cord-296347-fanlvxqs	1276	19	in	in	IN
cord-296347-fanlvxqs	1276	20	MHC	MHC	NNP
cord-296347-fanlvxqs	1276	21	class	class	NN
cord-296347-fanlvxqs	1276	22	II	II	NNP
cord-296347-fanlvxqs	1276	23	antigen	antigen	NN
cord-296347-fanlvxqs	1276	24	presentation	presentation	NN
cord-296347-fanlvxqs	1276	25	Shaping	shape	VBG
cord-296347-fanlvxqs	1276	26	the	the	DT
cord-296347-fanlvxqs	1276	27	T	T	NNP
cord-296347-fanlvxqs	1276	28	cell	cell	NN
cord-296347-fanlvxqs	1276	29	repertoire	repertoire	NN
cord-296347-fanlvxqs	1276	30	Signal	Signal	NNP
cord-296347-fanlvxqs	1276	31	sequences	sequence	NNS
cord-296347-fanlvxqs	1276	32	.	.	.
cord-296347-fanlvxqs	1277	1	The	the	DT
cord-296347-fanlvxqs	1277	2	limits	limit	NNS
cord-296347-fanlvxqs	1277	3	of	of	IN
cord-296347-fanlvxqs	1277	4	variation	variation	NN
cord-296347-fanlvxqs	1277	5	Major	major	JJ
cord-296347-fanlvxqs	1277	6	histocompatibility	histocompatibility	NN
cord-296347-fanlvxqs	1277	7	complex	complex	NN
cord-296347-fanlvxqs	1277	8	class	class	NN
cord-296347-fanlvxqs	1278	1	I	-PRON-	PRP
cord-296347-fanlvxqs	1278	2	allele	allele	NN
cord-296347-fanlvxqs	1278	3	-	-	HYPH
cord-296347-fanlvxqs	1278	4	specific	specific	JJ
cord-296347-fanlvxqs	1278	5	cooperative	cooperative	JJ
cord-296347-fanlvxqs	1278	6	and	and	CC
cord-296347-fanlvxqs	1278	7	competitive	competitive	JJ
cord-296347-fanlvxqs	1278	8	interactions	interaction	NNS
cord-296347-fanlvxqs	1278	9	between	between	IN
cord-296347-fanlvxqs	1278	10	immune	immune	JJ
cord-296347-fanlvxqs	1278	11	evasion	evasion	NN
cord-296347-fanlvxqs	1278	12	proteins	protein	NNS
cord-296347-fanlvxqs	1278	13	of	of	IN
cord-296347-fanlvxqs	1278	14	cytomegalovirus	cytomegalovirus	NNP
cord-296347-fanlvxqs	1278	15	C	C	NNP
cord-296347-fanlvxqs	1278	16	-	-	HYPH
cord-296347-fanlvxqs	1278	17	terminal	terminal	NN
cord-296347-fanlvxqs	1278	18	PAL	pal	NN
cord-296347-fanlvxqs	1278	19	motif	motif	NN
cord-296347-fanlvxqs	1278	20	of	of	IN
cord-296347-fanlvxqs	1278	21	presenilin	presenilin	NN
cord-296347-fanlvxqs	1278	22	and	and	CC
cord-296347-fanlvxqs	1278	23	presenilin	presenilin	NN
cord-296347-fanlvxqs	1278	24	homologues	homologue	NNS
cord-296347-fanlvxqs	1278	25	required	require	VBN
cord-296347-fanlvxqs	1278	26	for	for	IN
cord-296347-fanlvxqs	1278	27	normal	normal	JJ
cord-296347-fanlvxqs	1278	28	active	active	JJ
cord-296347-fanlvxqs	1278	29	site	site	NN
cord-296347-fanlvxqs	1278	30	conformation	conformation	NN
cord-296347-fanlvxqs	1278	31	Highmolecular	Highmolecular	NNP
cord-296347-fanlvxqs	1278	32	-	-	HYPH
cord-296347-fanlvxqs	1278	33	weight	weight	NN
cord-296347-fanlvxqs	1278	34	protein	protein	NN
cord-296347-fanlvxqs	1278	35	(	(	-LRB-
cord-296347-fanlvxqs	1278	36	pUL48	pUL48	NNP
cord-296347-fanlvxqs	1278	37	)	)	-RRB-
cord-296347-fanlvxqs	1278	38	of	of	IN
cord-296347-fanlvxqs	1278	39	human	human	JJ
cord-296347-fanlvxqs	1278	40	cytomegalovirus	cytomegalovirus	NN
cord-296347-fanlvxqs	1278	41	is	be	VBZ
cord-296347-fanlvxqs	1278	42	a	a	DT
cord-296347-fanlvxqs	1278	43	competent	competent	JJ
cord-296347-fanlvxqs	1278	44	deubiquitinating	deubiquitinating	NN
cord-296347-fanlvxqs	1278	45	protease	protease	NN
cord-296347-fanlvxqs	1278	46	:	:	:
cord-296347-fanlvxqs	1279	1	Mutant	mutant	JJ
cord-296347-fanlvxqs	1279	2	viruses	virus	NNS
cord-296347-fanlvxqs	1279	3	altered	alter	VBN
cord-296347-fanlvxqs	1279	4	in	in	IN
cord-296347-fanlvxqs	1279	5	its	-PRON-	PRP$
cord-296347-fanlvxqs	1279	6	active	active	JJ
cord-296347-fanlvxqs	1279	7	-	-	HYPH
cord-296347-fanlvxqs	1279	8	site	site	NN
cord-296347-fanlvxqs	1279	9	cysteine	cysteine	NN
cord-296347-fanlvxqs	1279	10	or	or	CC
cord-296347-fanlvxqs	1279	11	histidine	histidine	NN
cord-296347-fanlvxqs	1279	12	are	be	VBP
cord-296347-fanlvxqs	1279	13	viable	viable	JJ
cord-296347-fanlvxqs	1279	14	Regulation	regulation	NN
cord-296347-fanlvxqs	1279	15	of	of	IN
cord-296347-fanlvxqs	1279	16	tyrosinase	tyrosinase	NN
cord-296347-fanlvxqs	1279	17	trafficking	trafficking	NN
cord-296347-fanlvxqs	1279	18	and	and	CC
cord-296347-fanlvxqs	1279	19	processing	processing	NN
cord-296347-fanlvxqs	1279	20	by	by	IN
cord-296347-fanlvxqs	1279	21	presenilins	presenilin	NNS
cord-296347-fanlvxqs	1279	22	:	:	:
cord-296347-fanlvxqs	1279	23	Partial	partial	JJ
cord-296347-fanlvxqs	1279	24	loss	loss	NN
cord-296347-fanlvxqs	1279	25	of	of	IN
cord-296347-fanlvxqs	1279	26	function	function	NN
cord-296347-fanlvxqs	1279	27	by	by	IN
cord-296347-fanlvxqs	1279	28	familial	familial	JJ
cord-296347-fanlvxqs	1279	29	Alzheimer	Alzheimer	NNP
cord-296347-fanlvxqs	1279	30	's	's	POS
cord-296347-fanlvxqs	1279	31	disease	disease	NN
cord-296347-fanlvxqs	1279	32	mutation	mutation	NN
cord-296347-fanlvxqs	1279	33	Model	Model	NNP
cord-296347-fanlvxqs	1279	34	for	for	IN
cord-296347-fanlvxqs	1279	35	the	the	DT
cord-296347-fanlvxqs	1279	36	interaction	interaction	NN
cord-296347-fanlvxqs	1279	37	of	of	IN
cord-296347-fanlvxqs	1279	38	gammaherpesvirus	gammaherpesvirus	NNP
cord-296347-fanlvxqs	1279	39	68	68	CD
cord-296347-fanlvxqs	1279	40	RING	ring	NN
cord-296347-fanlvxqs	1279	41	-	-	HYPH
cord-296347-fanlvxqs	1279	42	CH	ch	NN
cord-296347-fanlvxqs	1279	43	finger	finger	NN
cord-296347-fanlvxqs	1279	44	protein	protein	NN
cord-296347-fanlvxqs	1279	45	mK3	mk3	NN
cord-296347-fanlvxqs	1279	46	with	with	IN
cord-296347-fanlvxqs	1279	47	major	major	JJ
cord-296347-fanlvxqs	1279	48	histocompatibility	histocompatibility	NN
cord-296347-fanlvxqs	1279	49	complex	complex	JJ
cord-296347-fanlvxqs	1279	50	class	class	NN
cord-296347-fanlvxqs	1279	51	I	i	NN
cord-296347-fanlvxqs	1279	52	and	and	CC
cord-296347-fanlvxqs	1279	53	the	the	DT
cord-296347-fanlvxqs	1279	54	peptide	peptide	NN
cord-296347-fanlvxqs	1279	55	-	-	HYPH
cord-296347-fanlvxqs	1279	56	loading	load	VBG
cord-296347-fanlvxqs	1279	57	complex	complex	JJ
cord-296347-fanlvxqs	1279	58	Requirements	requirement	NNS
cord-296347-fanlvxqs	1279	59	for	for	IN
cord-296347-fanlvxqs	1279	60	the	the	DT
cord-296347-fanlvxqs	1279	61	selective	selective	JJ
cord-296347-fanlvxqs	1279	62	degradation	degradation	NN
cord-296347-fanlvxqs	1279	63	of	of	IN
cord-296347-fanlvxqs	1279	64	endoplasmic	endoplasmic	NN
cord-296347-fanlvxqs	1279	65	reticulum	reticulum	NN
cord-296347-fanlvxqs	1279	66	-	-	HYPH
cord-296347-fanlvxqs	1279	67	resident	resident	JJ
cord-296347-fanlvxqs	1279	68	major	major	JJ
cord-296347-fanlvxqs	1279	69	histocompatibility	histocompatibility	NN
cord-296347-fanlvxqs	1279	70	complex	complex	JJ
cord-296347-fanlvxqs	1279	71	class	class	NN
cord-296347-fanlvxqs	1279	72	I	-PRON-	PRP
cord-296347-fanlvxqs	1279	73	proteins	protein	NNS
cord-296347-fanlvxqs	1279	74	by	by	IN
cord-296347-fanlvxqs	1279	75	the	the	DT
cord-296347-fanlvxqs	1279	76	viral	viral	JJ
cord-296347-fanlvxqs	1279	77	immune	immune	JJ
cord-296347-fanlvxqs	1279	78	evasion	evasion	NN
cord-296347-fanlvxqs	1279	79	molecule	molecule	NN
cord-296347-fanlvxqs	1279	80	mK3	mK3	NNP
cord-296347-fanlvxqs	1280	1	The	the	DT
cord-296347-fanlvxqs	1280	2	viral	viral	JJ
cord-296347-fanlvxqs	1280	3	E3	e3	NN
cord-296347-fanlvxqs	1280	4	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1280	5	ligase	ligase	NN
cord-296347-fanlvxqs	1280	6	mK3	mK3	NNP
cord-296347-fanlvxqs	1280	7	uses	use	VBZ
cord-296347-fanlvxqs	1280	8	the	the	DT
cord-296347-fanlvxqs	1280	9	Derlin	Derlin	NNP
cord-296347-fanlvxqs	1280	10	/	/	SYM
cord-296347-fanlvxqs	1280	11	p97	p97	CD
cord-296347-fanlvxqs	1280	12	endoplasmic	endoplasmic	NN
cord-296347-fanlvxqs	1280	13	reticulum	reticulum	NN
cord-296347-fanlvxqs	1280	14	-	-	HYPH
cord-296347-fanlvxqs	1280	15	associated	associate	VBN
cord-296347-fanlvxqs	1280	16	degradation	degradation	NN
cord-296347-fanlvxqs	1280	17	pathway	pathway	NN
cord-296347-fanlvxqs	1280	18	to	to	TO
cord-296347-fanlvxqs	1280	19	mediate	mediate	VB
cord-296347-fanlvxqs	1280	20	down	down	RB
cord-296347-fanlvxqs	1280	21	-	-	HYPH
cord-296347-fanlvxqs	1280	22	regulation	regulation	NN
cord-296347-fanlvxqs	1280	23	of	of	IN
cord-296347-fanlvxqs	1280	24	major	major	JJ
cord-296347-fanlvxqs	1280	25	histocompatibility	histocompatibility	NN
cord-296347-fanlvxqs	1280	26	complex	complex	JJ
cord-296347-fanlvxqs	1280	27	class	class	NN
cord-296347-fanlvxqs	1281	1	I	-PRON-	PRP
cord-296347-fanlvxqs	1281	2	proteins	protein	VBZ
cord-296347-fanlvxqs	1281	3	Degradation	degradation	NN
cord-296347-fanlvxqs	1281	4	of	of	IN
cord-296347-fanlvxqs	1281	5	CFTR	CFTR	NNP
cord-296347-fanlvxqs	1281	6	by	by	IN
cord-296347-fanlvxqs	1281	7	the	the	DT
cord-296347-fanlvxqs	1281	8	ubiquitinproteasome	ubiquitinproteasome	NN
cord-296347-fanlvxqs	1281	9	pathway	pathway	NN
cord-296347-fanlvxqs	1281	10	Identification	Identification	NNP
cord-296347-fanlvxqs	1281	11	of	of	IN
cord-296347-fanlvxqs	1281	12	signal	signal	NN
cord-296347-fanlvxqs	1281	13	peptide	peptide	NN
cord-296347-fanlvxqs	1281	14	peptidase	peptidase	NN
cord-296347-fanlvxqs	1281	15	,	,	,
cord-296347-fanlvxqs	1281	16	a	a	DT
cord-296347-fanlvxqs	1281	17	presenilin	presenilin	NN
cord-296347-fanlvxqs	1281	18	-	-	HYPH
cord-296347-fanlvxqs	1281	19	type	type	NN
cord-296347-fanlvxqs	1281	20	aspartic	aspartic	JJ
cord-296347-fanlvxqs	1281	21	protease	protease	NN
cord-296347-fanlvxqs	1281	22	Proteasome	Proteasome	NNP
cord-296347-fanlvxqs	1281	23	-	-	HYPH
cord-296347-fanlvxqs	1281	24	dependent	dependent	JJ
cord-296347-fanlvxqs	1281	25	endoplasmic	endoplasmic	NN
cord-296347-fanlvxqs	1281	26	reticulum	reticulum	NN
cord-296347-fanlvxqs	1281	27	-	-	HYPH
cord-296347-fanlvxqs	1281	28	associated	associate	VBN
cord-296347-fanlvxqs	1281	29	protein	protein	NN
cord-296347-fanlvxqs	1281	30	degradation	degradation	NN
cord-296347-fanlvxqs	1281	31	:	:	:
cord-296347-fanlvxqs	1282	1	An	an	DT
cord-296347-fanlvxqs	1282	2	unconventional	unconventional	JJ
cord-296347-fanlvxqs	1282	3	route	route	NN
cord-296347-fanlvxqs	1282	4	to	to	IN
cord-296347-fanlvxqs	1282	5	a	a	DT
cord-296347-fanlvxqs	1282	6	familiar	familiar	JJ
cord-296347-fanlvxqs	1282	7	fate	fate	NN
cord-296347-fanlvxqs	1283	1	The	the	DT
cord-296347-fanlvxqs	1283	2	human	human	JJ
cord-296347-fanlvxqs	1283	3	cytomegalovirus	cytomegalovirus	NN
cord-296347-fanlvxqs	1283	4	US11	US11	NNP
cord-296347-fanlvxqs	1283	5	gene	gene	NN
cord-296347-fanlvxqs	1283	6	product	product	NN
cord-296347-fanlvxqs	1283	7	dislocates	dislocate	VBZ
cord-296347-fanlvxqs	1283	8	MHC	MHC	NNP
cord-296347-fanlvxqs	1283	9	class	class	NN
cord-296347-fanlvxqs	1284	1	I	-PRON-	PRP
cord-296347-fanlvxqs	1284	2	heavy	heavy	JJ
cord-296347-fanlvxqs	1284	3	chains	chain	NNS
cord-296347-fanlvxqs	1284	4	from	from	IN
cord-296347-fanlvxqs	1284	5	the	the	DT
cord-296347-fanlvxqs	1284	6	endoplasmic	endoplasmic	NN
cord-296347-fanlvxqs	1284	7	reticulum	reticulum	NN
cord-296347-fanlvxqs	1284	8	to	to	IN
cord-296347-fanlvxqs	1284	9	the	the	DT
cord-296347-fanlvxqs	1284	10	cytosol	cytosol	NN
cord-296347-fanlvxqs	1285	1	Sec61-mediated	sec61-mediated	JJ
cord-296347-fanlvxqs	1285	2	transfer	transfer	NN
cord-296347-fanlvxqs	1285	3	of	of	IN
cord-296347-fanlvxqs	1285	4	a	a	DT
cord-296347-fanlvxqs	1285	5	membrane	membrane	NN
cord-296347-fanlvxqs	1285	6	protein	protein	NN
cord-296347-fanlvxqs	1285	7	from	from	IN
cord-296347-fanlvxqs	1285	8	the	the	DT
cord-296347-fanlvxqs	1285	9	endoplasmic	endoplasmic	NN
cord-296347-fanlvxqs	1285	10	reticulum	reticulum	NN
cord-296347-fanlvxqs	1285	11	to	to	IN
cord-296347-fanlvxqs	1285	12	the	the	DT
cord-296347-fanlvxqs	1285	13	proteasome	proteasome	NN
cord-296347-fanlvxqs	1285	14	for	for	IN
cord-296347-fanlvxqs	1285	15	destruction	destruction	NN
cord-296347-fanlvxqs	1285	16	Proteins	protein	NNS
cord-296347-fanlvxqs	1285	17	containing	contain	VBG
cord-296347-fanlvxqs	1285	18	the	the	DT
cord-296347-fanlvxqs	1285	19	UBA	UBA	NNP
cord-296347-fanlvxqs	1285	20	domain	domain	NN
cord-296347-fanlvxqs	1285	21	are	be	VBP
cord-296347-fanlvxqs	1285	22	able	able	JJ
cord-296347-fanlvxqs	1285	23	to	to	TO
cord-296347-fanlvxqs	1285	24	bind	bind	VB
cord-296347-fanlvxqs	1285	25	to	to	IN
cord-296347-fanlvxqs	1285	26	multi	multi	JJ
cord-296347-fanlvxqs	1285	27	-	-	JJ
cord-296347-fanlvxqs	1285	28	ubiquitin	ubiquitin	JJ
cord-296347-fanlvxqs	1285	29	chains	chain	NNS
cord-296347-fanlvxqs	1286	1	Human	human	JJ
cord-296347-fanlvxqs	1286	2	cytomegalovirus	cytomegalovirus	NN
cord-296347-fanlvxqs	1286	3	encodes	encode	VBZ
cord-296347-fanlvxqs	1286	4	an	an	DT
cord-296347-fanlvxqs	1286	5	MHC	MHC	NNP
cord-296347-fanlvxqs	1286	6	class	class	NN
cord-296347-fanlvxqs	1286	7	I	i	NN
cord-296347-fanlvxqs	1286	8	-	-	HYPH
cord-296347-fanlvxqs	1286	9	like	like	JJ
cord-296347-fanlvxqs	1286	10	molecule	molecule	NN
cord-296347-fanlvxqs	1286	11	(	(	-LRB-
cord-296347-fanlvxqs	1286	12	UL142	UL142	NNP
cord-296347-fanlvxqs	1286	13	)	)	-RRB-
cord-296347-fanlvxqs	1286	14	that	that	WDT
cord-296347-fanlvxqs	1286	15	functions	function	NNS
cord-296347-fanlvxqs	1286	16	to	to	TO
cord-296347-fanlvxqs	1286	17	inhibit	inhibit	VB
cord-296347-fanlvxqs	1286	18	NK	NK	NNP
cord-296347-fanlvxqs	1286	19	cell	cell	NN
cord-296347-fanlvxqs	1286	20	lysis	lysis	NN
cord-296347-fanlvxqs	1286	21	Degradative	Degradative	NNP
cord-296347-fanlvxqs	1286	22	organelles	organelle	NNS
cord-296347-fanlvxqs	1286	23	containing	contain	VBG
cord-296347-fanlvxqs	1286	24	mislocalized	mislocalized	JJ
cord-296347-fanlvxqs	1286	25	alpha	alpha	NN
cord-296347-fanlvxqs	1286	26	-	-	HYPH
cord-296347-fanlvxqs	1286	27	and	and	CC
cord-296347-fanlvxqs	1286	28	beta	beta	NN
cord-296347-fanlvxqs	1286	29	-	-	HYPH
cord-296347-fanlvxqs	1286	30	synuclein	synuclein	NN
cord-296347-fanlvxqs	1287	1	proliferate	proliferate	VB
cord-296347-fanlvxqs	1287	2	in	in	IN
cord-296347-fanlvxqs	1287	3	presenilin-1	presenilin-1	NNP
cord-296347-fanlvxqs	1287	4	null	null	JJ
cord-296347-fanlvxqs	1287	5	neurons	neuron	NNS
cord-296347-fanlvxqs	1288	1	A	a	DT
cord-296347-fanlvxqs	1288	2	family	family	NN
cord-296347-fanlvxqs	1288	3	of	of	IN
cord-296347-fanlvxqs	1288	4	mammalian	mammalian	JJ
cord-296347-fanlvxqs	1288	5	F	F	NNP
cord-296347-fanlvxqs	1288	6	-	-	HYPH
cord-296347-fanlvxqs	1288	7	box	box	NNP
cord-296347-fanlvxqs	1288	8	proteins	protein	NNS
cord-296347-fanlvxqs	1288	9	p97	p97	CD
cord-296347-fanlvxqs	1288	10	,	,	,
cord-296347-fanlvxqs	1288	11	a	a	DT
cord-296347-fanlvxqs	1288	12	protein	protein	NN
cord-296347-fanlvxqs	1288	13	coping	cope	VBG
cord-296347-fanlvxqs	1288	14	with	with	IN
cord-296347-fanlvxqs	1288	15	multiple	multiple	JJ
cord-296347-fanlvxqs	1288	16	identities	identity	NNS
cord-296347-fanlvxqs	1289	1	Neddylation	Neddylation	NNP
cord-296347-fanlvxqs	1289	2	and	and	CC
cord-296347-fanlvxqs	1289	3	deneddylation	deneddylation	NN
cord-296347-fanlvxqs	1289	4	regulate	regulate	VBP
cord-296347-fanlvxqs	1289	5	Cul1	Cul1	NNP
cord-296347-fanlvxqs	1289	6	and	and	CC
cord-296347-fanlvxqs	1289	7	Cul3	Cul3	NNP
cord-296347-fanlvxqs	1289	8	protein	protein	NN
cord-296347-fanlvxqs	1289	9	accumulation	accumulation	NN
cord-296347-fanlvxqs	1289	10	Intramembrane	Intramembrane	NNP
cord-296347-fanlvxqs	1289	11	proteolysis	proteolysis	NN
cord-296347-fanlvxqs	1289	12	by	by	IN
cord-296347-fanlvxqs	1289	13	presenilin	presenilin	NN
cord-296347-fanlvxqs	1289	14	and	and	CC
cord-296347-fanlvxqs	1289	15	presenilin	presenilin	NN
cord-296347-fanlvxqs	1289	16	-	-	HYPH
cord-296347-fanlvxqs	1289	17	like	like	JJ
cord-296347-fanlvxqs	1289	18	proteases	protease	NNS
cord-296347-fanlvxqs	1289	19	Parkin	Parkin	NNP
cord-296347-fanlvxqs	1289	20	phosphorylation	phosphorylation	NN
cord-296347-fanlvxqs	1289	21	and	and	CC
cord-296347-fanlvxqs	1289	22	modulation	modulation	NN
cord-296347-fanlvxqs	1289	23	of	of	IN
cord-296347-fanlvxqs	1289	24	its	-PRON-	PRP$
cord-296347-fanlvxqs	1289	25	E3	e3	NN
cord-296347-fanlvxqs	1289	26	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1289	27	ligase	ligase	NN
cord-296347-fanlvxqs	1289	28	activity	activity	NN
cord-296347-fanlvxqs	1289	29	Novel	Novel	NNP
cord-296347-fanlvxqs	1289	30	aspects	aspect	NNS
cord-296347-fanlvxqs	1289	31	of	of	IN
cord-296347-fanlvxqs	1289	32	degradation	degradation	NN
cord-296347-fanlvxqs	1289	33	of	of	IN
cord-296347-fanlvxqs	1289	34	T	T	NNP
cord-296347-fanlvxqs	1289	35	cell	cell	NN
cord-296347-fanlvxqs	1289	36	receptor	receptor	NN
cord-296347-fanlvxqs	1289	37	subunits	subunit	NNS
cord-296347-fanlvxqs	1289	38	from	from	IN
cord-296347-fanlvxqs	1289	39	the	the	DT
cord-296347-fanlvxqs	1289	40	endoplasmic	endoplasmic	NN
cord-296347-fanlvxqs	1289	41	reticulum	reticulum	NN
cord-296347-fanlvxqs	1289	42	(	(	-LRB-
cord-296347-fanlvxqs	1289	43	ER	ER	NNP
cord-296347-fanlvxqs	1289	44	)	)	-RRB-
cord-296347-fanlvxqs	1289	45	in	in	IN
cord-296347-fanlvxqs	1289	46	T	T	NNP
cord-296347-fanlvxqs	1289	47	cells	cell	NNS
cord-296347-fanlvxqs	1289	48	:	:	:
cord-296347-fanlvxqs	1290	1	Importance	importance	NN
cord-296347-fanlvxqs	1290	2	of	of	IN
cord-296347-fanlvxqs	1290	3	oligosaccharide	oligosaccharide	NN
cord-296347-fanlvxqs	1290	4	processing	processing	NN
cord-296347-fanlvxqs	1290	5	,	,	,
cord-296347-fanlvxqs	1290	6	ubiquitination	ubiquitination	NN
cord-296347-fanlvxqs	1290	7	,	,	,
cord-296347-fanlvxqs	1290	8	and	and	CC
cord-296347-fanlvxqs	1290	9	proteasome	proteasome	NN
cord-296347-fanlvxqs	1290	10	-	-	HYPH
cord-296347-fanlvxqs	1290	11	dependent	dependent	JJ
cord-296347-fanlvxqs	1290	12	removal	removal	NN
cord-296347-fanlvxqs	1290	13	from	from	IN
cord-296347-fanlvxqs	1290	14	ER	ER	NNP
cord-296347-fanlvxqs	1290	15	membranes	membrane	NNS
cord-296347-fanlvxqs	1290	16	Nedd4	Nedd4	NNP
cord-296347-fanlvxqs	1290	17	regulates	regulate	VBZ
cord-296347-fanlvxqs	1290	18	egress	egress	NN
cord-296347-fanlvxqs	1290	19	of	of	IN
cord-296347-fanlvxqs	1290	20	Ebola	Ebola	NNP
cord-296347-fanlvxqs	1290	21	viruslike	viruslike	NN
cord-296347-fanlvxqs	1290	22	particles	particle	NNS
cord-296347-fanlvxqs	1290	23	from	from	IN
cord-296347-fanlvxqs	1290	24	host	host	NN
cord-296347-fanlvxqs	1290	25	cells	cell	NNS
cord-296347-fanlvxqs	1291	1	The	the	DT
cord-296347-fanlvxqs	1291	2	AAA	AAA	NNP
cord-296347-fanlvxqs	1291	3	ATPase	ATPase	NNP
cord-296347-fanlvxqs	1291	4	Cdc48	Cdc48	NNP
cord-296347-fanlvxqs	1291	5	/	/	SYM
cord-296347-fanlvxqs	1291	6	p97	p97	CD
cord-296347-fanlvxqs	1291	7	and	and	CC
cord-296347-fanlvxqs	1291	8	its	-PRON-	PRP$
cord-296347-fanlvxqs	1291	9	partners	partner	NNS
cord-296347-fanlvxqs	1291	10	transport	transport	VBP
cord-296347-fanlvxqs	1291	11	proteins	protein	NNS
cord-296347-fanlvxqs	1291	12	from	from	IN
cord-296347-fanlvxqs	1291	13	the	the	DT
cord-296347-fanlvxqs	1291	14	ER	ER	NNP
cord-296347-fanlvxqs	1291	15	into	into	IN
cord-296347-fanlvxqs	1291	16	the	the	DT
cord-296347-fanlvxqs	1291	17	cytosol	cytosol	NN
cord-296347-fanlvxqs	1291	18	Function	Function	NNP
cord-296347-fanlvxqs	1291	19	of	of	IN
cord-296347-fanlvxqs	1291	20	the	the	DT
cord-296347-fanlvxqs	1291	21	p97-Ufd1-Npl4	p97-Ufd1-Npl4	NNPS
cord-296347-fanlvxqs	1291	22	complex	complex	JJ
cord-296347-fanlvxqs	1291	23	in	in	IN
cord-296347-fanlvxqs	1291	24	retrotranslocation	retrotranslocation	NN
cord-296347-fanlvxqs	1291	25	from	from	IN
cord-296347-fanlvxqs	1291	26	the	the	DT
cord-296347-fanlvxqs	1291	27	ER	ER	NNP
cord-296347-fanlvxqs	1291	28	to	to	IN
cord-296347-fanlvxqs	1291	29	the	the	DT
cord-296347-fanlvxqs	1291	30	cytosol	cytosol	NN
cord-296347-fanlvxqs	1291	31	:	:	:
cord-296347-fanlvxqs	1291	32	Dual	dual	JJ
cord-296347-fanlvxqs	1291	33	recognition	recognition	NN
cord-296347-fanlvxqs	1291	34	of	of	IN
cord-296347-fanlvxqs	1291	35	nonubiquitinated	nonubiquitinated	JJ
cord-296347-fanlvxqs	1291	36	polypeptide	polypeptide	NN
cord-296347-fanlvxqs	1291	37	segments	segment	NNS
cord-296347-fanlvxqs	1291	38	and	and	CC
cord-296347-fanlvxqs	1291	39	polyubiquitin	polyubiquitin	NNP
cord-296347-fanlvxqs	1291	40	chains	chain	NNS
cord-296347-fanlvxqs	1292	1	A	a	DT
cord-296347-fanlvxqs	1292	2	membrane	membrane	NN
cord-296347-fanlvxqs	1292	3	protein	protein	NN
cord-296347-fanlvxqs	1292	4	complex	complex	NN
cord-296347-fanlvxqs	1292	5	mediates	mediate	VBZ
cord-296347-fanlvxqs	1292	6	retro	retro	JJ
cord-296347-fanlvxqs	1292	7	-	-	HYPH
cord-296347-fanlvxqs	1292	8	translocation	translocation	NN
cord-296347-fanlvxqs	1292	9	from	from	IN
cord-296347-fanlvxqs	1292	10	the	the	DT
cord-296347-fanlvxqs	1292	11	ER	ER	NNP
cord-296347-fanlvxqs	1292	12	lumen	lumen	NN
cord-296347-fanlvxqs	1292	13	into	into	IN
cord-296347-fanlvxqs	1292	14	the	the	DT
cord-296347-fanlvxqs	1292	15	cytosol	cytosol	NN
cord-296347-fanlvxqs	1292	16	Inaugural	Inaugural	NNP
cord-296347-fanlvxqs	1292	17	Article	Article	NNP
cord-296347-fanlvxqs	1292	18	:	:	:
cord-296347-fanlvxqs	1292	19	Recruitment	Recruitment	NNP
cord-296347-fanlvxqs	1292	20	of	of	IN
cord-296347-fanlvxqs	1292	21	the	the	DT
cord-296347-fanlvxqs	1292	22	p97	p97	CD
cord-296347-fanlvxqs	1292	23	ATPase	ATPase	NNP
cord-296347-fanlvxqs	1292	24	and	and	CC
cord-296347-fanlvxqs	1292	25	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1292	26	ligases	ligase	NNS
cord-296347-fanlvxqs	1292	27	to	to	IN
cord-296347-fanlvxqs	1292	28	the	the	DT
cord-296347-fanlvxqs	1292	29	site	site	NN
cord-296347-fanlvxqs	1292	30	of	of	IN
cord-296347-fanlvxqs	1292	31	retrotranslocation	retrotranslocation	NN
cord-296347-fanlvxqs	1292	32	at	at	IN
cord-296347-fanlvxqs	1292	33	the	the	DT
cord-296347-fanlvxqs	1292	34	endoplasmic	endoplasmic	NN
cord-296347-fanlvxqs	1292	35	reticulum	reticulum	NN
cord-296347-fanlvxqs	1292	36	membrane	membrane	NN
cord-296347-fanlvxqs	1292	37	Viral	viral	JJ
cord-296347-fanlvxqs	1292	38	interference	interference	NN
cord-296347-fanlvxqs	1292	39	with	with	IN
cord-296347-fanlvxqs	1292	40	antigen	antigen	NN
cord-296347-fanlvxqs	1292	41	presentation	presentation	NN
cord-296347-fanlvxqs	1292	42	At	at	IN
cord-296347-fanlvxqs	1292	43	the	the	DT
cord-296347-fanlvxqs	1292	44	crossroads	crossroad	NNS
cord-296347-fanlvxqs	1292	45	of	of	IN
cord-296347-fanlvxqs	1292	46	cell	cell	NN
cord-296347-fanlvxqs	1292	47	biology	biology	NN
cord-296347-fanlvxqs	1292	48	and	and	CC
cord-296347-fanlvxqs	1292	49	immunology	immunology	NN
cord-296347-fanlvxqs	1292	50	:	:	:
cord-296347-fanlvxqs	1292	51	DRiPs	drips	ADD
cord-296347-fanlvxqs	1292	52	and	and	CC
cord-296347-fanlvxqs	1292	53	other	other	JJ
cord-296347-fanlvxqs	1292	54	sources	source	NNS
cord-296347-fanlvxqs	1292	55	of	of	IN
cord-296347-fanlvxqs	1292	56	peptide	peptide	NN
cord-296347-fanlvxqs	1292	57	ligands	ligand	NNS
cord-296347-fanlvxqs	1292	58	for	for	IN
cord-296347-fanlvxqs	1292	59	MHC	MHC	NNP
cord-296347-fanlvxqs	1292	60	class	class	NN
cord-296347-fanlvxqs	1293	1	I	-PRON-	PRP
cord-296347-fanlvxqs	1293	2	molecules	molecule	VBZ
cord-296347-fanlvxqs	1293	3	Self	self	NN
cord-296347-fanlvxqs	1293	4	-	-	HYPH
cord-296347-fanlvxqs	1293	5	inhibition	inhibition	NN
cord-296347-fanlvxqs	1293	6	of	of	IN
cord-296347-fanlvxqs	1293	7	synthesis	synthesis	NN
cord-296347-fanlvxqs	1293	8	and	and	CC
cord-296347-fanlvxqs	1293	9	antigen	antigen	NN
cord-296347-fanlvxqs	1293	10	presentation	presentation	NN
cord-296347-fanlvxqs	1293	11	by	by	IN
cord-296347-fanlvxqs	1294	1	Epstein	Epstein	NNP
cord-296347-fanlvxqs	1294	2	-	-	HYPH
cord-296347-fanlvxqs	1294	3	Barr	Barr	NNP
cord-296347-fanlvxqs	1294	4	virus	virus	NN
cord-296347-fanlvxqs	1294	5	-	-	HYPH
cord-296347-fanlvxqs	1294	6	encoded	encode	VBN
cord-296347-fanlvxqs	1294	7	EBNA1	EBNA1	NNS
cord-296347-fanlvxqs	1295	1	A	a	DT
cord-296347-fanlvxqs	1295	2	novel	novel	JJ
cord-296347-fanlvxqs	1295	3	role	role	NN
cord-296347-fanlvxqs	1295	4	for	for	IN
cord-296347-fanlvxqs	1295	5	N	n	NN
cord-296347-fanlvxqs	1295	6	-	-	HYPH
cord-296347-fanlvxqs	1295	7	glycans	glycan	NNS
cord-296347-fanlvxqs	1295	8	in	in	IN
cord-296347-fanlvxqs	1295	9	the	the	DT
cord-296347-fanlvxqs	1295	10	ERAD	ERAD	NNP
cord-296347-fanlvxqs	1295	11	system	system	NN
cord-296347-fanlvxqs	1295	12	E3	e3	NN
cord-296347-fanlvxqs	1295	13	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1295	14	ligase	ligase	NN
cord-296347-fanlvxqs	1295	15	that	that	WDT
cord-296347-fanlvxqs	1295	16	recognizes	recognize	VBZ
cord-296347-fanlvxqs	1295	17	sugar	sugar	NN
cord-296347-fanlvxqs	1295	18	chains	chain	NNS
cord-296347-fanlvxqs	1296	1	Fbs2	Fbs2	NNP
cord-296347-fanlvxqs	1296	2	is	be	VBZ
cord-296347-fanlvxqs	1296	3	a	a	DT
cord-296347-fanlvxqs	1296	4	new	new	JJ
cord-296347-fanlvxqs	1296	5	member	member	NN
cord-296347-fanlvxqs	1296	6	of	of	IN
cord-296347-fanlvxqs	1296	7	the	the	DT
cord-296347-fanlvxqs	1296	8	E3	E3	NNP
cord-296347-fanlvxqs	1296	9	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1296	10	ligase	ligase	NN
cord-296347-fanlvxqs	1296	11	family	family	NN
cord-296347-fanlvxqs	1296	12	that	that	WDT
cord-296347-fanlvxqs	1296	13	recognizes	recognize	VBZ
cord-296347-fanlvxqs	1296	14	sugar	sugar	NN
cord-296347-fanlvxqs	1296	15	chains	chain	NNS
cord-296347-fanlvxqs	1296	16	Induction	Induction	NNP
cord-296347-fanlvxqs	1296	17	of	of	IN
cord-296347-fanlvxqs	1296	18	APOBEC3	APOBEC3	NNP
cord-296347-fanlvxqs	1296	19	G	g	NN
cord-296347-fanlvxqs	1296	20	ubiquitination	ubiquitination	NN
cord-296347-fanlvxqs	1296	21	and	and	CC
cord-296347-fanlvxqs	1296	22	degradation	degradation	NN
cord-296347-fanlvxqs	1296	23	by	by	IN
cord-296347-fanlvxqs	1296	24	an	an	DT
cord-296347-fanlvxqs	1296	25	HIV-1	HIV-1	NNP
cord-296347-fanlvxqs	1296	26	Vif	Vif	NNP
cord-296347-fanlvxqs	1296	27	-	-	HYPH
cord-296347-fanlvxqs	1296	28	Cul5-SCF	Cul5-SCF	NNP
cord-296347-fanlvxqs	1296	29	complex	complex	NNP
cord-296347-fanlvxqs	1296	30	Physical	Physical	NNP
cord-296347-fanlvxqs	1296	31	association	association	NNP
cord-296347-fanlvxqs	1296	32	of	of	IN
cord-296347-fanlvxqs	1296	33	the	the	DT
cord-296347-fanlvxqs	1296	34	K3	K3	NNP
cord-296347-fanlvxqs	1296	35	protein	protein	NN
cord-296347-fanlvxqs	1296	36	of	of	IN
cord-296347-fanlvxqs	1296	37	gamma-2	gamma-2	NNP
cord-296347-fanlvxqs	1296	38	herpesvirus	herpesvirus	NN
cord-296347-fanlvxqs	1296	39	68	68	CD
cord-296347-fanlvxqs	1296	40	with	with	IN
cord-296347-fanlvxqs	1296	41	major	major	JJ
cord-296347-fanlvxqs	1296	42	histocompatibility	histocompatibility	NN
cord-296347-fanlvxqs	1296	43	complex	complex	JJ
cord-296347-fanlvxqs	1296	44	class	class	NN
cord-296347-fanlvxqs	1297	1	I	-PRON-	PRP
cord-296347-fanlvxqs	1297	2	molecules	molecule	VBZ
cord-296347-fanlvxqs	1297	3	with	with	IN
cord-296347-fanlvxqs	1297	4	impaired	impaired	JJ
cord-296347-fanlvxqs	1297	5	peptide	peptide	NN
cord-296347-fanlvxqs	1297	6	and	and	CC
cord-296347-fanlvxqs	1298	1	beta(2)-microglobulin	beta(2)-microglobulin	NNP
cord-296347-fanlvxqs	1298	2	assembly	assembly	NNP
cord-296347-fanlvxqs	1298	3	Influenza	Influenza	NNP
cord-296347-fanlvxqs	1298	4	B	B	NNP
cord-296347-fanlvxqs	1298	5	virus	virus	NN
cord-296347-fanlvxqs	1298	6	NS1	ns1	NN
cord-296347-fanlvxqs	1298	7	protein	protein	NN
cord-296347-fanlvxqs	1298	8	inhibits	inhibit	VBZ
cord-296347-fanlvxqs	1298	9	conjugation	conjugation	NN
cord-296347-fanlvxqs	1298	10	of	of	IN
cord-296347-fanlvxqs	1298	11	the	the	DT
cord-296347-fanlvxqs	1298	12	interferon	interferon	NN
cord-296347-fanlvxqs	1298	13	(	(	-LRB-
cord-296347-fanlvxqs	1298	14	IFN)-induced	ifn)-induce	VBN
cord-296347-fanlvxqs	1298	15	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1298	16	-	-	HYPH
cord-296347-fanlvxqs	1298	17	like	like	JJ
cord-296347-fanlvxqs	1298	18	ISG15	ISG15	NNP
cord-296347-fanlvxqs	1298	19	protein	protein	NN
cord-296347-fanlvxqs	1298	20	Structural	structural	JJ
cord-296347-fanlvxqs	1298	21	basis	basis	NN
cord-296347-fanlvxqs	1298	22	for	for	IN
cord-296347-fanlvxqs	1298	23	ubiquitinlike	ubiquitinlike	JJ
cord-296347-fanlvxqs	1298	24	ISG	ISG	NNP
cord-296347-fanlvxqs	1298	25	15	15	CD
cord-296347-fanlvxqs	1298	26	protein	protein	NN
cord-296347-fanlvxqs	1298	27	binding	bind	VBG
cord-296347-fanlvxqs	1298	28	to	to	IN
cord-296347-fanlvxqs	1298	29	the	the	DT
cord-296347-fanlvxqs	1298	30	NS1	ns1	NN
cord-296347-fanlvxqs	1298	31	protein	protein	NN
cord-296347-fanlvxqs	1298	32	of	of	IN
cord-296347-fanlvxqs	1298	33	influenza	influenza	NN
cord-296347-fanlvxqs	1298	34	B	B	NNP
cord-296347-fanlvxqs	1298	35	virus	virus	NN
cord-296347-fanlvxqs	1298	36	:	:	:
cord-296347-fanlvxqs	1299	1	A	a	DT
cord-296347-fanlvxqs	1299	2	protein	protein	NN
cord-296347-fanlvxqs	1299	3	-	-	HYPH
cord-296347-fanlvxqs	1299	4	protein	protein	NN
cord-296347-fanlvxqs	1299	5	interaction	interaction	NN
cord-296347-fanlvxqs	1299	6	function	function	NN
cord-296347-fanlvxqs	1299	7	that	that	WDT
cord-296347-fanlvxqs	1299	8	is	be	VBZ
cord-296347-fanlvxqs	1299	9	not	not	RB
cord-296347-fanlvxqs	1299	10	shared	share	VBN
cord-296347-fanlvxqs	1299	11	by	by	IN
cord-296347-fanlvxqs	1299	12	the	the	DT
cord-296347-fanlvxqs	1299	13	corresponding	corresponding	JJ
cord-296347-fanlvxqs	1299	14	N	n	CD
cord-296347-fanlvxqs	1299	15	-	-	HYPH
cord-296347-fanlvxqs	1299	16	terminal	terminal	NN
cord-296347-fanlvxqs	1299	17	domain	domain	NN
cord-296347-fanlvxqs	1299	18	of	of	IN
cord-296347-fanlvxqs	1299	19	the	the	DT
cord-296347-fanlvxqs	1299	20	NS1	ns1	NN
cord-296347-fanlvxqs	1299	21	protein	protein	NN
cord-296347-fanlvxqs	1299	22	of	of	IN
cord-296347-fanlvxqs	1299	23	influenza	influenza	NN
cord-296347-fanlvxqs	1299	24	A	a	DT
cord-296347-fanlvxqs	1299	25	virus	virus	NN
cord-296347-fanlvxqs	1299	26	Plant	plant	NN
cord-296347-fanlvxqs	1299	27	RNAi	RNAi	NNS
cord-296347-fanlvxqs	1299	28	:	:	:
cord-296347-fanlvxqs	1300	1	How	how	WRB
cord-296347-fanlvxqs	1300	2	a	a	DT
cord-296347-fanlvxqs	1300	3	viral	viral	JJ
cord-296347-fanlvxqs	1300	4	silencing	silencing	NN
cord-296347-fanlvxqs	1300	5	suppressor	suppressor	NN
cord-296347-fanlvxqs	1300	6	inactivates	inactivate	VBZ
cord-296347-fanlvxqs	1300	7	siRNA	siRNA	NNP
cord-296347-fanlvxqs	1301	1	The	the	DT
cord-296347-fanlvxqs	1301	2	cytidine	cytidine	NN
cord-296347-fanlvxqs	1301	3	deaminase	deaminase	NN
cord-296347-fanlvxqs	1301	4	CEM15	CEM15	NNP
cord-296347-fanlvxqs	1301	5	induces	induce	VBZ
cord-296347-fanlvxqs	1301	6	hypermutation	hypermutation	NN
cord-296347-fanlvxqs	1301	7	in	in	IN
cord-296347-fanlvxqs	1301	8	newly	newly	RB
cord-296347-fanlvxqs	1301	9	synthesized	synthesize	VBN
cord-296347-fanlvxqs	1301	10	HIV-1	HIV-1	NNP
cord-296347-fanlvxqs	1301	11	DNA	DNA	NNP
cord-296347-fanlvxqs	1301	12	Structure	Structure	NNP
cord-296347-fanlvxqs	1301	13	of	of	IN
cord-296347-fanlvxqs	1301	14	the	the	DT
cord-296347-fanlvxqs	1301	15	AAA	AAA	NNP
cord-296347-fanlvxqs	1301	16	ATPase	ATPase	NNP
cord-296347-fanlvxqs	1301	17	p97	p97	CD
cord-296347-fanlvxqs	1302	1	The	the	DT
cord-296347-fanlvxqs	1302	2	UbcH8	UbcH8	NNP
cord-296347-fanlvxqs	1302	3	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1302	4	E2	e2	NN
cord-296347-fanlvxqs	1302	5	enzyme	enzyme	NN
cord-296347-fanlvxqs	1302	6	is	be	VBZ
cord-296347-fanlvxqs	1302	7	also	also	RB
cord-296347-fanlvxqs	1302	8	the	the	DT
cord-296347-fanlvxqs	1302	9	E2	E2	NNP
cord-296347-fanlvxqs	1302	10	enzyme	enzyme	NN
cord-296347-fanlvxqs	1302	11	for	for	IN
cord-296347-fanlvxqs	1302	12	ISG15	ISG15	NNP
cord-296347-fanlvxqs	1302	13	,	,	,
cord-296347-fanlvxqs	1302	14	an	an	DT
cord-296347-fanlvxqs	1302	15	IFN	IFN	NNP
cord-296347-fanlvxqs	1302	16	-	-	HYPH
cord-296347-fanlvxqs	1302	17	alpha	alpha	NN
cord-296347-fanlvxqs	1302	18	/	/	SYM
cord-296347-fanlvxqs	1302	19	beta	beta	NN
cord-296347-fanlvxqs	1302	20	-	-	HYPH
cord-296347-fanlvxqs	1302	21	induced	induce	VBN
cord-296347-fanlvxqs	1302	22	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1302	23	-	-	HYPH
cord-296347-fanlvxqs	1302	24	like	like	JJ
cord-296347-fanlvxqs	1302	25	protein	protein	NN
cord-296347-fanlvxqs	1302	26	Structure	Structure	NNP
cord-296347-fanlvxqs	1302	27	of	of	IN
cord-296347-fanlvxqs	1302	28	the	the	DT
cord-296347-fanlvxqs	1302	29	Cul1-Rbx1-Skp1-F	Cul1-Rbx1-Skp1-F	NNP
cord-296347-fanlvxqs	1302	30	boxSkp2	boxskp2	NN
cord-296347-fanlvxqs	1302	31	SCF	scf	NN
cord-296347-fanlvxqs	1302	32	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1302	33	ligase	ligase	NN
cord-296347-fanlvxqs	1302	34	complex	complex	JJ
cord-296347-fanlvxqs	1302	35	Chlamydia	Chlamydia	NNP
cord-296347-fanlvxqs	1302	36	inhibits	inhibit	VBZ
cord-296347-fanlvxqs	1302	37	interferon	interferon	NN
cord-296347-fanlvxqs	1302	38	gamma	gamma	NN
cord-296347-fanlvxqs	1302	39	-	-	HYPH
cord-296347-fanlvxqs	1302	40	inducible	inducible	JJ
cord-296347-fanlvxqs	1302	41	major	major	JJ
cord-296347-fanlvxqs	1302	42	histocompatibility	histocompatibility	NN
cord-296347-fanlvxqs	1302	43	complex	complex	JJ
cord-296347-fanlvxqs	1302	44	class	class	NN
cord-296347-fanlvxqs	1302	45	II	ii	CD
cord-296347-fanlvxqs	1302	46	expression	expression	NN
cord-296347-fanlvxqs	1302	47	by	by	IN
cord-296347-fanlvxqs	1302	48	degradation	degradation	NN
cord-296347-fanlvxqs	1302	49	of	of	IN
cord-296347-fanlvxqs	1302	50	upstream	upstream	JJ
cord-296347-fanlvxqs	1302	51	stimulatory	stimulatory	JJ
cord-296347-fanlvxqs	1302	52	factor	factor	NN
cord-296347-fanlvxqs	1302	53	1	1	CD
cord-296347-fanlvxqs	1302	54	Yersinia	Yersinia	NNP
cord-296347-fanlvxqs	1302	55	virulence	virulence	NN
cord-296347-fanlvxqs	1302	56	factor	factor	NN
cord-296347-fanlvxqs	1302	57	YopJ	YopJ	NNP
cord-296347-fanlvxqs	1302	58	acts	act	VBZ
cord-296347-fanlvxqs	1302	59	as	as	IN
cord-296347-fanlvxqs	1302	60	a	a	DT
cord-296347-fanlvxqs	1302	61	deubiquitinase	deubiquitinase	NN
cord-296347-fanlvxqs	1302	62	to	to	TO
cord-296347-fanlvxqs	1302	63	inhibit	inhibit	VB
cord-296347-fanlvxqs	1303	1	NF	nf	NN
cord-296347-fanlvxqs	1303	2	-	-	HYPH
cord-296347-fanlvxqs	1303	3	kappa	kappa	NNP
cord-296347-fanlvxqs	1303	4	B	B	NNP
cord-296347-fanlvxqs	1303	5	activation	activation	NN
cord-296347-fanlvxqs	1303	6	A	a	DT
cord-296347-fanlvxqs	1303	7	cytomegaloviral	cytomegaloviral	JJ
cord-296347-fanlvxqs	1303	8	protein	protein	NN
cord-296347-fanlvxqs	1303	9	reveals	reveal	VBZ
cord-296347-fanlvxqs	1303	10	a	a	DT
cord-296347-fanlvxqs	1303	11	dual	dual	JJ
cord-296347-fanlvxqs	1303	12	role	role	NN
cord-296347-fanlvxqs	1303	13	for	for	IN
cord-296347-fanlvxqs	1303	14	STAT2	STAT2	NNS
cord-296347-fanlvxqs	1303	15	in	in	IN
cord-296347-fanlvxqs	1303	16	IFN-{gamma	ifn-{gamma	NN
cord-296347-fanlvxqs	1303	17	}	}	-RRB-
cord-296347-fanlvxqs	1303	18	signaling	signal	VBG
cord-296347-fanlvxqs	1303	19	and	and	CC
cord-296347-fanlvxqs	1303	20	antiviral	antiviral	JJ
cord-296347-fanlvxqs	1303	21	responses	response	NNS
cord-296347-fanlvxqs	1303	22	NK	NK	NNP
cord-296347-fanlvxqs	1303	23	cell	cell	NN
cord-296347-fanlvxqs	1303	24	regulation	regulation	NN
cord-296347-fanlvxqs	1303	25	of	of	IN
cord-296347-fanlvxqs	1303	26	T	T	NNP
cord-296347-fanlvxqs	1303	27	cell	cell	NN
cord-296347-fanlvxqs	1303	28	-	-	HYPH
cord-296347-fanlvxqs	1303	29	mediated	mediate	VBN
cord-296347-fanlvxqs	1303	30	responses	response	NNS
cord-296347-fanlvxqs	1304	1	The	the	DT
cord-296347-fanlvxqs	1304	2	interferon	interferon	NN
cord-296347-fanlvxqs	1304	3	-	-	HYPH
cord-296347-fanlvxqs	1304	4	inducible	inducible	JJ
cord-296347-fanlvxqs	1304	5	ubiquitin	ubiquitin	NN
cord-296347-fanlvxqs	1304	6	-	-	HYPH
cord-296347-fanlvxqs	1304	7	protein	protein	NN
cord-296347-fanlvxqs	1304	8	isopeptide	isopeptide	NN
cord-296347-fanlvxqs	1304	9	ligase	ligase	NN
cord-296347-fanlvxqs	1304	10	(	(	-LRB-
cord-296347-fanlvxqs	1304	11	E3	E3	NNP
cord-296347-fanlvxqs	1304	12	)	)	-RRB-
cord-296347-fanlvxqs	1305	1	EFP	EFP	NNP
cord-296347-fanlvxqs	1305	2	also	also	RB
cord-296347-fanlvxqs	1305	3	functions	function	VBZ
cord-296347-fanlvxqs	1305	4	as	as	IN
cord-296347-fanlvxqs	1305	5	an	an	DT
cord-296347-fanlvxqs	1305	6	ISG15	ISG15	NNP
cord-296347-fanlvxqs	1305	7	E3	e3	NN
cord-296347-fanlvxqs	1305	8	ligase	ligase	NN
cord-296347-fanlvxqs	1305	9	We	-PRON-	PRP
cord-296347-fanlvxqs	1305	10	thank	thank	VBP
cord-296347-fanlvxqs	1305	11	Howard	Howard	NNP
cord-296347-fanlvxqs	1305	12	C.	C.	NNP
cord-296347-fanlvxqs	1305	13	Hang	Hang	NNP
cord-296347-fanlvxqs	1305	14	for	for	IN
cord-296347-fanlvxqs	1305	15	help	help	NN
cord-296347-fanlvxqs	1305	16	with	with	IN
cord-296347-fanlvxqs	1305	17	the	the	DT
cord-296347-fanlvxqs	1305	18	text	text	NN
cord-296347-fanlvxqs	1305	19	and	and	CC
cord-296347-fanlvxqs	1305	20	the	the	DT
cord-296347-fanlvxqs	1305	21	figures	figure	NNS
cord-296347-fanlvxqs	1305	22	and	and	CC
cord-296347-fanlvxqs	1305	23	apologize	apologize	VB
cord-296347-fanlvxqs	1305	24	to	to	IN
cord-296347-fanlvxqs	1305	25	all	all	DT
cord-296347-fanlvxqs	1305	26	colleagues	colleague	NNS
cord-296347-fanlvxqs	1305	27	whose	whose	WP$
cord-296347-fanlvxqs	1305	28	work	work	NN
cord-296347-fanlvxqs	1305	29	we	-PRON-	PRP
cord-296347-fanlvxqs	1305	30	may	may	MD
cord-296347-fanlvxqs	1305	31	have	have	VB
cord-296347-fanlvxqs	1305	32	not	not	RB
cord-296347-fanlvxqs	1305	33	included	include	VBN
cord-296347-fanlvxqs	1305	34	.	.	.
cord-296347-fanlvxqs	1306	1	This	this	DT
cord-296347-fanlvxqs	1306	2	work	work	NN
cord-296347-fanlvxqs	1306	3	was	be	VBD
cord-296347-fanlvxqs	1306	4	supported	support	VBN
cord-296347-fanlvxqs	1306	5	by	by	IN
cord-296347-fanlvxqs	1306	6	NIH	NIH	NNP
cord-296347-fanlvxqs	1306	7	grants	grant	NNS
cord-296347-fanlvxqs	1306	8	to	to	IN
cord-296347-fanlvxqs	1306	9	H.L.P.	h.l.p.	NN