id sid tid token lemma pos cord-298169-2133gahl 1 1 key key NN cord-298169-2133gahl 1 2 : : : cord-298169-2133gahl 2 1 cord-298169 cord-298169 NNP cord-298169-2133gahl 2 2 - - HYPH cord-298169-2133gahl 2 3 2133gahl 2133gahl JJ cord-298169-2133gahl 2 4 authors author NNS cord-298169-2133gahl 2 5 : : : cord-298169-2133gahl 2 6 Tamouza Tamouza NNP cord-298169-2133gahl 2 7 , , , cord-298169-2133gahl 2 8 Ryad Ryad NNP cord-298169-2133gahl 2 9 ; ; : cord-298169-2133gahl 2 10 Krishnamoorthy Krishnamoorthy NNP cord-298169-2133gahl 2 11 , , , cord-298169-2133gahl 2 12 Rajagopal Rajagopal NNP cord-298169-2133gahl 2 13 ; ; : cord-298169-2133gahl 2 14 Leboyer Leboyer NNP cord-298169-2133gahl 2 15 , , , cord-298169-2133gahl 2 16 Marion Marion NNP cord-298169-2133gahl 2 17 title title NN cord-298169-2133gahl 2 18 : : : cord-298169-2133gahl 2 19 Understanding understand VBG cord-298169-2133gahl 2 20 the the DT cord-298169-2133gahl 2 21 genetic genetic JJ cord-298169-2133gahl 2 22 contribution contribution NN cord-298169-2133gahl 2 23 of of IN cord-298169-2133gahl 2 24 the the DT cord-298169-2133gahl 2 25 Human Human NNP cord-298169-2133gahl 2 26 Leukocyte Leukocyte NNP cord-298169-2133gahl 2 27 Antigen Antigen NNP cord-298169-2133gahl 2 28 system system NN cord-298169-2133gahl 2 29 to to IN cord-298169-2133gahl 2 30 common common JJ cord-298169-2133gahl 2 31 major major JJ cord-298169-2133gahl 2 32 psychiatric psychiatric JJ cord-298169-2133gahl 2 33 disorders disorder NNS cord-298169-2133gahl 2 34 in in IN cord-298169-2133gahl 2 35 a a DT cord-298169-2133gahl 2 36 world world NN cord-298169-2133gahl 2 37 pandemic pandemic NN cord-298169-2133gahl 2 38 context context NN cord-298169-2133gahl 2 39 date date NN cord-298169-2133gahl 2 40 : : : cord-298169-2133gahl 2 41 2020 2020 CD cord-298169-2133gahl 2 42 - - SYM cord-298169-2133gahl 2 43 10 10 CD cord-298169-2133gahl 2 44 - - HYPH cord-298169-2133gahl 2 45 05 05 CD cord-298169-2133gahl 2 46 journal journal NN cord-298169-2133gahl 2 47 : : : cord-298169-2133gahl 3 1 Brain Brain NNP cord-298169-2133gahl 3 2 Behav Behav NNP cord-298169-2133gahl 3 3 Immun Immun NNP cord-298169-2133gahl 3 4 DOI DOI NNP cord-298169-2133gahl 3 5 : : : cord-298169-2133gahl 3 6 10.1016 10.1016 CD cord-298169-2133gahl 3 7 / / SYM cord-298169-2133gahl 3 8 j.bbi.2020.09.033 j.bbi.2020.09.033 NNP cord-298169-2133gahl 3 9 sha sha NNP cord-298169-2133gahl 3 10 : : : cord-298169-2133gahl 3 11 d78e3fe32ef50ade4cd07e76dc9625af0ee664a2 d78e3fe32ef50ade4cd07e76dc9625af0ee664a2 NNP cord-298169-2133gahl 3 12 doc_id doc_id NNP cord-298169-2133gahl 3 13 : : : cord-298169-2133gahl 3 14 298169 298169 CD cord-298169-2133gahl 3 15 cord_uid cord_uid NNS cord-298169-2133gahl 3 16 : : : cord-298169-2133gahl 4 1 2133gahl 2133gahl CD cord-298169-2133gahl 5 1 The the DT cord-298169-2133gahl 5 2 human human JJ cord-298169-2133gahl 5 3 leukocyte leukocyte NN cord-298169-2133gahl 5 4 antigen antigen NN cord-298169-2133gahl 5 5 ( ( -LRB- cord-298169-2133gahl 5 6 HLA HLA NNP cord-298169-2133gahl 5 7 ) ) -RRB- cord-298169-2133gahl 5 8 is be VBZ cord-298169-2133gahl 5 9 a a DT cord-298169-2133gahl 5 10 complex complex JJ cord-298169-2133gahl 5 11 genetic genetic JJ cord-298169-2133gahl 5 12 system system NN cord-298169-2133gahl 5 13 that that WDT cord-298169-2133gahl 5 14 encodes encode VBZ cord-298169-2133gahl 5 15 proteins protein NNS cord-298169-2133gahl 5 16 which which WDT cord-298169-2133gahl 5 17 predominantly predominantly RB cord-298169-2133gahl 5 18 regulate regulate VBP cord-298169-2133gahl 5 19 immune immune JJ cord-298169-2133gahl 5 20 / / SYM cord-298169-2133gahl 5 21 inflammatory inflammatory JJ cord-298169-2133gahl 5 22 processes process NNS cord-298169-2133gahl 5 23 . . . cord-298169-2133gahl 6 1 It -PRON- PRP cord-298169-2133gahl 6 2 can can MD cord-298169-2133gahl 6 3 be be VB cord-298169-2133gahl 6 4 involved involve VBN cord-298169-2133gahl 6 5 in in IN cord-298169-2133gahl 6 6 a a DT cord-298169-2133gahl 6 7 variety variety NN cord-298169-2133gahl 6 8 of of IN cord-298169-2133gahl 6 9 immuno immuno JJ cord-298169-2133gahl 6 10 - - HYPH cord-298169-2133gahl 6 11 inflammatory inflammatory JJ cord-298169-2133gahl 6 12 disorders disorder NNS cord-298169-2133gahl 6 13 ranging range VBG cord-298169-2133gahl 6 14 from from IN cord-298169-2133gahl 6 15 infections infection NNS cord-298169-2133gahl 6 16 to to IN cord-298169-2133gahl 6 17 autoimmunity autoimmunity NN cord-298169-2133gahl 6 18 and and CC cord-298169-2133gahl 6 19 cancers cancer NNS cord-298169-2133gahl 6 20 . . . cord-298169-2133gahl 7 1 The the DT cord-298169-2133gahl 7 2 HLA HLA NNP cord-298169-2133gahl 7 3 system system NN cord-298169-2133gahl 7 4 is be VBZ cord-298169-2133gahl 7 5 also also RB cord-298169-2133gahl 7 6 suggested suggest VBN cord-298169-2133gahl 7 7 to to TO cord-298169-2133gahl 7 8 be be VB cord-298169-2133gahl 7 9 involved involve VBN cord-298169-2133gahl 7 10 in in IN cord-298169-2133gahl 7 11 neurodevelopment neurodevelopment NN cord-298169-2133gahl 7 12 and and CC cord-298169-2133gahl 7 13 neuroplasticity neuroplasticity NN cord-298169-2133gahl 7 14 , , , cord-298169-2133gahl 7 15 especially especially RB cord-298169-2133gahl 7 16 through through IN cord-298169-2133gahl 7 17 microglia microglia JJ cord-298169-2133gahl 7 18 regulation regulation NN cord-298169-2133gahl 7 19 and and CC cord-298169-2133gahl 7 20 synaptic synaptic JJ cord-298169-2133gahl 7 21 pruning pruning NN cord-298169-2133gahl 7 22 . . . cord-298169-2133gahl 8 1 Consequently consequently RB cord-298169-2133gahl 8 2 , , , cord-298169-2133gahl 8 3 this this DT cord-298169-2133gahl 8 4 highly highly RB cord-298169-2133gahl 8 5 polymorphic polymorphic JJ cord-298169-2133gahl 8 6 gene gene NN cord-298169-2133gahl 8 7 region region NN cord-298169-2133gahl 8 8 has have VBZ cord-298169-2133gahl 8 9 recently recently RB cord-298169-2133gahl 8 10 emerged emerge VBN cord-298169-2133gahl 8 11 as as IN cord-298169-2133gahl 8 12 a a DT cord-298169-2133gahl 8 13 major major JJ cord-298169-2133gahl 8 14 player player NN cord-298169-2133gahl 8 15 in in IN cord-298169-2133gahl 8 16 the the DT cord-298169-2133gahl 8 17 etiology etiology NN cord-298169-2133gahl 8 18 of of IN cord-298169-2133gahl 8 19 several several JJ cord-298169-2133gahl 8 20 major major JJ cord-298169-2133gahl 8 21 psychiatric psychiatric JJ cord-298169-2133gahl 8 22 disorders disorder NNS cord-298169-2133gahl 8 23 , , , cord-298169-2133gahl 8 24 such such JJ cord-298169-2133gahl 8 25 as as IN cord-298169-2133gahl 8 26 schizophrenia schizophrenia NN cord-298169-2133gahl 8 27 , , , cord-298169-2133gahl 8 28 autism autism NN cord-298169-2133gahl 8 29 spectrum spectrum NN cord-298169-2133gahl 8 30 disorder disorder NN cord-298169-2133gahl 8 31 and and CC cord-298169-2133gahl 8 32 bipolar bipolar JJ cord-298169-2133gahl 8 33 disorder disorder NN cord-298169-2133gahl 8 34 and and CC cord-298169-2133gahl 8 35 with with IN cord-298169-2133gahl 8 36 less less JJR cord-298169-2133gahl 8 37 evidence evidence NN cord-298169-2133gahl 8 38 for for IN cord-298169-2133gahl 8 39 major major JJ cord-298169-2133gahl 8 40 depressive depressive JJ cord-298169-2133gahl 8 41 disorders disorder NNS cord-298169-2133gahl 8 42 and and CC cord-298169-2133gahl 8 43 attention attention NN cord-298169-2133gahl 8 44 deficit deficit NN cord-298169-2133gahl 8 45 hyperactivity hyperactivity NN cord-298169-2133gahl 8 46 disorder disorder NN cord-298169-2133gahl 8 47 . . . cord-298169-2133gahl 9 1 We -PRON- PRP cord-298169-2133gahl 9 2 thus thus RB cord-298169-2133gahl 9 3 review review VBP cord-298169-2133gahl 9 4 here here RB cord-298169-2133gahl 9 5 the the DT cord-298169-2133gahl 9 6 role role NN cord-298169-2133gahl 9 7 of of IN cord-298169-2133gahl 9 8 HLA HLA NNP cord-298169-2133gahl 9 9 genes gene NNS cord-298169-2133gahl 9 10 in in IN cord-298169-2133gahl 9 11 particular particular JJ cord-298169-2133gahl 9 12 subgroups subgroup NNS cord-298169-2133gahl 9 13 of of IN cord-298169-2133gahl 9 14 psychiatric psychiatric JJ cord-298169-2133gahl 9 15 disorders disorder NNS cord-298169-2133gahl 9 16 and and CC cord-298169-2133gahl 9 17 foresee foresee VB cord-298169-2133gahl 9 18 their -PRON- PRP$ cord-298169-2133gahl 9 19 potential potential JJ cord-298169-2133gahl 9 20 implication implication NN cord-298169-2133gahl 9 21 in in IN cord-298169-2133gahl 9 22 future future JJ cord-298169-2133gahl 9 23 research research NN cord-298169-2133gahl 9 24 . . . cord-298169-2133gahl 10 1 In in IN cord-298169-2133gahl 10 2 particular particular JJ cord-298169-2133gahl 10 3 , , , cord-298169-2133gahl 10 4 given give VBN cord-298169-2133gahl 10 5 the the DT cord-298169-2133gahl 10 6 prominent prominent JJ cord-298169-2133gahl 10 7 role role NN cord-298169-2133gahl 10 8 that that WDT cord-298169-2133gahl 10 9 the the DT cord-298169-2133gahl 10 10 HLA HLA NNP cord-298169-2133gahl 10 11 system system NN cord-298169-2133gahl 10 12 plays play VBZ cord-298169-2133gahl 10 13 in in IN cord-298169-2133gahl 10 14 the the DT cord-298169-2133gahl 10 15 regulation regulation NN cord-298169-2133gahl 10 16 of of IN cord-298169-2133gahl 10 17 viral viral JJ cord-298169-2133gahl 10 18 infection infection NN cord-298169-2133gahl 10 19 , , , cord-298169-2133gahl 10 20 this this DT cord-298169-2133gahl 10 21 review review NN cord-298169-2133gahl 10 22 is be VBZ cord-298169-2133gahl 10 23 particularly particularly RB cord-298169-2133gahl 10 24 timely timely JJ cord-298169-2133gahl 10 25 in in IN cord-298169-2133gahl 10 26 the the DT cord-298169-2133gahl 10 27 context context NN cord-298169-2133gahl 10 28 of of IN cord-298169-2133gahl 10 29 the the DT cord-298169-2133gahl 10 30 Covid-19 covid-19 NN cord-298169-2133gahl 10 31 pandemic pandemic NN cord-298169-2133gahl 10 32 . . . cord-298169-2133gahl 11 1 Since since IN cord-298169-2133gahl 11 2 the the DT cord-298169-2133gahl 11 3 first first JJ cord-298169-2133gahl 11 4 description description NN cord-298169-2133gahl 11 5 of of IN cord-298169-2133gahl 11 6 an an DT cord-298169-2133gahl 11 7 association association NN cord-298169-2133gahl 11 8 between between IN cord-298169-2133gahl 11 9 human human JJ cord-298169-2133gahl 11 10 leukocyte leukocyte NN cord-298169-2133gahl 11 11 antigen antigen NN cord-298169-2133gahl 11 12 ( ( -LRB- cord-298169-2133gahl 11 13 HLA)-B HLA)-B NNP cord-298169-2133gahl 11 14 and and CC cord-298169-2133gahl 11 15 Hodgkin Hodgkin NNP cord-298169-2133gahl 11 16 lymphoma lymphoma NN cord-298169-2133gahl 11 17 ( ( -LRB- cord-298169-2133gahl 11 18 Amiel Amiel NNP cord-298169-2133gahl 11 19 , , , cord-298169-2133gahl 11 20 1967 1967 CD cord-298169-2133gahl 11 21 ) ) -RRB- cord-298169-2133gahl 12 1 the the DT cord-298169-2133gahl 12 2 highly highly RB cord-298169-2133gahl 12 3 polymorphic polymorphic JJ cord-298169-2133gahl 12 4 HLA HLA NNP cord-298169-2133gahl 12 5 gene gene NN cord-298169-2133gahl 12 6 cluster cluster NN cord-298169-2133gahl 12 7 has have VBZ cord-298169-2133gahl 12 8 been be VBN cord-298169-2133gahl 12 9 linked link VBN cord-298169-2133gahl 12 10 to to IN cord-298169-2133gahl 12 11 a a DT cord-298169-2133gahl 12 12 wide wide JJ cord-298169-2133gahl 12 13 array array NN cord-298169-2133gahl 12 14 of of IN cord-298169-2133gahl 12 15 immune immune JJ cord-298169-2133gahl 12 16 / / SYM cord-298169-2133gahl 12 17 inflammatory inflammatory JJ cord-298169-2133gahl 12 18 disorders disorder NNS cord-298169-2133gahl 12 19 , , , cord-298169-2133gahl 12 20 including include VBG cord-298169-2133gahl 12 21 now now RB cord-298169-2133gahl 12 22 psychiatric psychiatric JJ cord-298169-2133gahl 12 23 disorders disorder NNS cord-298169-2133gahl 12 24 . . . cord-298169-2133gahl 13 1 Recently recently RB cord-298169-2133gahl 13 2 , , , cord-298169-2133gahl 13 3 a a DT cord-298169-2133gahl 13 4 strong strong JJ cord-298169-2133gahl 13 5 association association NN cord-298169-2133gahl 13 6 between between IN cord-298169-2133gahl 13 7 schizophrenia schizophrenia NNP cord-298169-2133gahl 13 8 and and CC cord-298169-2133gahl 13 9 the the DT cord-298169-2133gahl 13 10 Major Major NNP cord-298169-2133gahl 13 11 Histocompatibility Histocompatibility NNP cord-298169-2133gahl 13 12 Complex Complex NNP cord-298169-2133gahl 13 13 ( ( -LRB- cord-298169-2133gahl 13 14 MHC MHC NNP cord-298169-2133gahl 13 15 ) ) -RRB- cord-298169-2133gahl 13 16 , , , cord-298169-2133gahl 13 17 which which WDT cord-298169-2133gahl 13 18 hosts host VBZ cord-298169-2133gahl 13 19 the the DT cord-298169-2133gahl 13 20 HLA HLA NNP cord-298169-2133gahl 13 21 gene gene NN cord-298169-2133gahl 13 22 cluster cluster NN cord-298169-2133gahl 13 23 , , , cord-298169-2133gahl 13 24 was be VBD cord-298169-2133gahl 13 25 reported report VBN cord-298169-2133gahl 13 26 by by IN cord-298169-2133gahl 13 27 the the DT cord-298169-2133gahl 13 28 Psychiatry Psychiatry NNP cord-298169-2133gahl 13 29 Genomic Genomic NNP cord-298169-2133gahl 13 30 Consortium Consortium NNP cord-298169-2133gahl 13 31 ( ( -LRB- cord-298169-2133gahl 13 32 Ripke Ripke NNP cord-298169-2133gahl 13 33 et et FW cord-298169-2133gahl 13 34 al al NNP cord-298169-2133gahl 13 35 , , , cord-298169-2133gahl 13 36 2014 2014 CD cord-298169-2133gahl 13 37 ) ) -RRB- cord-298169-2133gahl 13 38 . . . cord-298169-2133gahl 14 1 This this DT cord-298169-2133gahl 14 2 finding finding NN cord-298169-2133gahl 14 3 extends extend VBZ cord-298169-2133gahl 14 4 the the DT cord-298169-2133gahl 14 5 long long RB cord-298169-2133gahl 14 6 - - HYPH cord-298169-2133gahl 14 7 standing stand VBG cord-298169-2133gahl 14 8 observation observation NN cord-298169-2133gahl 14 9 of of IN cord-298169-2133gahl 14 10 links link NNS cord-298169-2133gahl 14 11 between between IN cord-298169-2133gahl 14 12 HLA HLA NNP cord-298169-2133gahl 14 13 and and CC cord-298169-2133gahl 14 14 psychiatric psychiatric JJ cord-298169-2133gahl 14 15 disorders disorder NNS cord-298169-2133gahl 15 1 ( ( -LRB- cord-298169-2133gahl 15 2 Eberhard Eberhard NNP cord-298169-2133gahl 15 3 et et NNP cord-298169-2133gahl 15 4 al al NNP cord-298169-2133gahl 15 5 , , , cord-298169-2133gahl 15 6 1975 1975 CD cord-298169-2133gahl 15 7 ) ) -RRB- cord-298169-2133gahl 15 8 . . . cord-298169-2133gahl 16 1 Given give VBN cord-298169-2133gahl 16 2 the the DT cord-298169-2133gahl 16 3 prominent prominent JJ cord-298169-2133gahl 16 4 role role NN cord-298169-2133gahl 16 5 of of IN cord-298169-2133gahl 16 6 HLA HLA NNP cord-298169-2133gahl 16 7 gene gene NN cord-298169-2133gahl 16 8 cluster cluster NN cord-298169-2133gahl 16 9 in in IN cord-298169-2133gahl 16 10 the the DT cord-298169-2133gahl 16 11 regulation regulation NN cord-298169-2133gahl 16 12 of of IN cord-298169-2133gahl 16 13 immuno immuno JJ cord-298169-2133gahl 16 14 - - HYPH cord-298169-2133gahl 16 15 inflammatory inflammatory JJ cord-298169-2133gahl 16 16 processes process NNS cord-298169-2133gahl 16 17 , , , cord-298169-2133gahl 16 18 as as RB cord-298169-2133gahl 16 19 well well RB cord-298169-2133gahl 16 20 as as IN cord-298169-2133gahl 16 21 in in IN cord-298169-2133gahl 16 22 neurodevelopment neurodevelopment NN cord-298169-2133gahl 16 23 and and CC cord-298169-2133gahl 16 24 neuroplasticity neuroplasticity NN cord-298169-2133gahl 16 25 , , , cord-298169-2133gahl 16 26 through through IN cord-298169-2133gahl 16 27 microglia microglia JJ cord-298169-2133gahl 16 28 regulation regulation NN cord-298169-2133gahl 16 29 and and CC cord-298169-2133gahl 16 30 synaptic synaptic JJ cord-298169-2133gahl 16 31 pruning pruning NN cord-298169-2133gahl 16 32 ( ( -LRB- cord-298169-2133gahl 16 33 Moktari Moktari NNP cord-298169-2133gahl 16 34 and and CC cord-298169-2133gahl 16 35 Lachman Lachman NNP cord-298169-2133gahl 16 36 , , , cord-298169-2133gahl 16 37 2016 2016 CD cord-298169-2133gahl 16 38 ) ) -RRB- cord-298169-2133gahl 16 39 , , , cord-298169-2133gahl 16 40 it -PRON- PRP cord-298169-2133gahl 16 41 was be VBD cord-298169-2133gahl 16 42 expected expect VBN cord-298169-2133gahl 16 43 that that IN cord-298169-2133gahl 16 44 HLA HLA NNP cord-298169-2133gahl 16 45 alleles allele NNS cord-298169-2133gahl 16 46 would would MD cord-298169-2133gahl 16 47 play play VB cord-298169-2133gahl 16 48 a a DT cord-298169-2133gahl 16 49 major major JJ cord-298169-2133gahl 16 50 role role NN cord-298169-2133gahl 16 51 in in IN cord-298169-2133gahl 16 52 the the DT cord-298169-2133gahl 16 53 pathophysiology pathophysiology NN cord-298169-2133gahl 16 54 of of IN cord-298169-2133gahl 16 55 psychiatric psychiatric JJ cord-298169-2133gahl 16 56 disorders disorder NNS cord-298169-2133gahl 16 57 . . . cord-298169-2133gahl 17 1 Convergent convergent JJ cord-298169-2133gahl 17 2 results result NNS cord-298169-2133gahl 17 3 now now RB cord-298169-2133gahl 17 4 show show VBP cord-298169-2133gahl 17 5 that that IN cord-298169-2133gahl 17 6 this this DT cord-298169-2133gahl 17 7 is be VBZ cord-298169-2133gahl 17 8 particularly particularly RB cord-298169-2133gahl 17 9 relevant relevant JJ cord-298169-2133gahl 17 10 for for IN cord-298169-2133gahl 17 11 Autism Autism NNP cord-298169-2133gahl 17 12 Spectrum Spectrum NNP cord-298169-2133gahl 17 13 Disorders Disorders NNPS cord-298169-2133gahl 17 14 ( ( -LRB- cord-298169-2133gahl 17 15 ASD ASD NNP cord-298169-2133gahl 17 16 ) ) -RRB- cord-298169-2133gahl 17 17 , , , cord-298169-2133gahl 17 18 schizophrenia schizophrenia NN cord-298169-2133gahl 17 19 or or CC cord-298169-2133gahl 17 20 bipolar bipolar JJ cord-298169-2133gahl 17 21 disorders disorder NNS cord-298169-2133gahl 17 22 , , , cord-298169-2133gahl 17 23 all all DT cord-298169-2133gahl 17 24 known know VBN cord-298169-2133gahl 17 25 to to TO cord-298169-2133gahl 17 26 be be VB cord-298169-2133gahl 17 27 associated associate VBN cord-298169-2133gahl 17 28 with with IN cord-298169-2133gahl 17 29 chronic chronic JJ cord-298169-2133gahl 17 30 low low JJ cord-298169-2133gahl 17 31 - - HYPH cord-298169-2133gahl 17 32 grade grade NN cord-298169-2133gahl 17 33 inflammation inflammation NN cord-298169-2133gahl 17 34 and and CC cord-298169-2133gahl 17 35 comorbid comorbid VBN cord-298169-2133gahl 17 36 autoimmune autoimmune JJ cord-298169-2133gahl 17 37 diseases disease NNS cord-298169-2133gahl 18 1 ( ( -LRB- cord-298169-2133gahl 18 2 Pape Pape NNP cord-298169-2133gahl 18 3 et et NNP cord-298169-2133gahl 18 4 al al NNP cord-298169-2133gahl 18 5 , , , cord-298169-2133gahl 18 6 2019 2019 CD cord-298169-2133gahl 18 7 ) ) -RRB- cord-298169-2133gahl 18 8 . . . cord-298169-2133gahl 19 1 The the DT cord-298169-2133gahl 19 2 HLA HLA NNP cord-298169-2133gahl 19 3 system system NN cord-298169-2133gahl 19 4 is be VBZ cord-298169-2133gahl 19 5 expected expect VBN cord-298169-2133gahl 19 6 to to TO cord-298169-2133gahl 19 7 influence influence VB cord-298169-2133gahl 19 8 both both CC cord-298169-2133gahl 19 9 the the DT cord-298169-2133gahl 19 10 early early JJ cord-298169-2133gahl 19 11 development development NN cord-298169-2133gahl 19 12 and and CC cord-298169-2133gahl 19 13 the the DT cord-298169-2133gahl 19 14 course course NN cord-298169-2133gahl 19 15 of of IN cord-298169-2133gahl 19 16 psychiatric psychiatric JJ cord-298169-2133gahl 19 17 disorders disorder NNS cord-298169-2133gahl 19 18 . . . cord-298169-2133gahl 20 1 The the DT cord-298169-2133gahl 20 2 MHC MHC NNP cord-298169-2133gahl 20 3 is be VBZ cord-298169-2133gahl 20 4 a a DT cord-298169-2133gahl 20 5 four four CD cord-298169-2133gahl 20 6 megabases megabase NNS cord-298169-2133gahl 20 7 region region NN cord-298169-2133gahl 20 8 located locate VBN cord-298169-2133gahl 20 9 on on IN cord-298169-2133gahl 20 10 the the DT cord-298169-2133gahl 20 11 short short JJ cord-298169-2133gahl 20 12 arm arm NN cord-298169-2133gahl 20 13 of of IN cord-298169-2133gahl 20 14 the the DT cord-298169-2133gahl 20 15 chromosome chromosome NN cord-298169-2133gahl 20 16 6 6 CD cord-298169-2133gahl 20 17 ( ( -LRB- cord-298169-2133gahl 20 18 6p21.3 6p21.3 CD cord-298169-2133gahl 20 19 - - SYM cord-298169-2133gahl 20 20 22.1 22.1 CD cord-298169-2133gahl 20 21 ) ) -RRB- cord-298169-2133gahl 20 22 and and CC cord-298169-2133gahl 20 23 is be VBZ cord-298169-2133gahl 20 24 one one CD cord-298169-2133gahl 20 25 of of IN cord-298169-2133gahl 20 26 the the DT cord-298169-2133gahl 20 27 most most RBS cord-298169-2133gahl 20 28 polymorphic polymorphic JJ cord-298169-2133gahl 20 29 and and CC cord-298169-2133gahl 20 30 gene gene NN cord-298169-2133gahl 20 31 dense dense JJ cord-298169-2133gahl 20 32 regions region NNS cord-298169-2133gahl 20 33 of of IN cord-298169-2133gahl 20 34 the the DT cord-298169-2133gahl 20 35 human human JJ cord-298169-2133gahl 20 36 genome genome NN cord-298169-2133gahl 20 37 ( ( -LRB- cord-298169-2133gahl 20 38 Trowsdale Trowsdale NNP cord-298169-2133gahl 20 39 and and CC cord-298169-2133gahl 20 40 Knight Knight NNP cord-298169-2133gahl 20 41 , , , cord-298169-2133gahl 20 42 2013 2013 CD cord-298169-2133gahl 20 43 ) ) -RRB- cord-298169-2133gahl 20 44 , , , cord-298169-2133gahl 20 45 ) ) -RRB- cord-298169-2133gahl 20 46 . . . cord-298169-2133gahl 21 1 This this DT cord-298169-2133gahl 21 2 region region NN cord-298169-2133gahl 21 3 hosts host VBZ cord-298169-2133gahl 21 4 the the DT cord-298169-2133gahl 21 5 HLA HLA NNP cord-298169-2133gahl 21 6 gene gene NN cord-298169-2133gahl 21 7 cluster cluster NN cord-298169-2133gahl 21 8 , , , cord-298169-2133gahl 21 9 which which WDT cord-298169-2133gahl 21 10 is be VBZ cord-298169-2133gahl 21 11 physically physically RB cord-298169-2133gahl 21 12 divided divide VBN cord-298169-2133gahl 21 13 into into IN cord-298169-2133gahl 21 14 three three CD cord-298169-2133gahl 21 15 functionally functionally RB cord-298169-2133gahl 21 16 distinct distinct JJ cord-298169-2133gahl 21 17 sub sub NN cord-298169-2133gahl 21 18 - - HYPH cord-298169-2133gahl 21 19 regions region NNS cord-298169-2133gahl 21 20 : : : cord-298169-2133gahl 21 21 i i NN cord-298169-2133gahl 21 22 ) ) -RRB- cord-298169-2133gahl 22 1 the the DT cord-298169-2133gahl 22 2 HLA HLA NNP cord-298169-2133gahl 22 3 - - HYPH cord-298169-2133gahl 22 4 class class NN cord-298169-2133gahl 22 5 I I NNP cord-298169-2133gahl 22 6 region region NN cord-298169-2133gahl 22 7 includes include VBZ cord-298169-2133gahl 22 8 the the DT cord-298169-2133gahl 22 9 classical classical JJ cord-298169-2133gahl 22 10 HLA HLA NNP cord-298169-2133gahl 22 11 - - HYPH cord-298169-2133gahl 22 12 A A NNP cord-298169-2133gahl 22 13 , , , cord-298169-2133gahl 22 14 HLA HLA NNP cord-298169-2133gahl 22 15 - - HYPH cord-298169-2133gahl 22 16 B B NNP cord-298169-2133gahl 22 17 , , , cord-298169-2133gahl 22 18 and and CC cord-298169-2133gahl 22 19 HLA HLA NNP cord-298169-2133gahl 22 20 - - HYPH cord-298169-2133gahl 22 21 C C NNP cord-298169-2133gahl 22 22 genes gene NNS cord-298169-2133gahl 22 23 as as RB cord-298169-2133gahl 22 24 well well RB cord-298169-2133gahl 22 25 as as IN cord-298169-2133gahl 22 26 the the DT cord-298169-2133gahl 22 27 non non JJ cord-298169-2133gahl 22 28 - - JJ cord-298169-2133gahl 22 29 classical classical JJ cord-298169-2133gahl 22 30 HLA HLA NNP cord-298169-2133gahl 22 31 - - HYPH cord-298169-2133gahl 22 32 E E NNP cord-298169-2133gahl 22 33 , , , cord-298169-2133gahl 22 34 HLA HLA NNP cord-298169-2133gahl 22 35 - - HYPH cord-298169-2133gahl 22 36 F F NNP cord-298169-2133gahl 22 37 and and CC cord-298169-2133gahl 22 38 HLA HLA NNP cord-298169-2133gahl 22 39 - - HYPH cord-298169-2133gahl 22 40 G g NN cord-298169-2133gahl 22 41 loci locus NNS cord-298169-2133gahl 22 42 . . . cord-298169-2133gahl 23 1 The the DT cord-298169-2133gahl 23 2 three three CD cord-298169-2133gahl 23 3 classical classical JJ cord-298169-2133gahl 23 4 HLA HLA NNP cord-298169-2133gahl 23 5 genes gene NNS cord-298169-2133gahl 23 6 act act VBP cord-298169-2133gahl 23 7 to to TO cord-298169-2133gahl 23 8 regulate regulate VB cord-298169-2133gahl 23 9 antigen antigen NN cord-298169-2133gahl 23 10 presentation presentation NN cord-298169-2133gahl 23 11 to to IN cord-298169-2133gahl 23 12 CD8 CD8 NNP cord-298169-2133gahl 23 13 + + CC cord-298169-2133gahl 23 14 T T NNP cord-298169-2133gahl 23 15 - - HYPH cord-298169-2133gahl 23 16 lymphocytes lymphocyte NNS cord-298169-2133gahl 23 17 , , , cord-298169-2133gahl 23 18 whilst whilst IN cord-298169-2133gahl 23 19 the the DT cord-298169-2133gahl 23 20 non non JJ cord-298169-2133gahl 23 21 - - JJ cord-298169-2133gahl 23 22 classical classical JJ cord-298169-2133gahl 23 23 genes gene NNS cord-298169-2133gahl 23 24 are be VBP cord-298169-2133gahl 23 25 mainly mainly RB cord-298169-2133gahl 23 26 implicated implicate VBN cord-298169-2133gahl 23 27 in in IN cord-298169-2133gahl 23 28 different different JJ cord-298169-2133gahl 23 29 immunomodulatory immunomodulatory JJ cord-298169-2133gahl 23 30 functions function NNS cord-298169-2133gahl 23 31 ; ; : cord-298169-2133gahl 23 32 ii ii LS cord-298169-2133gahl 23 33 ) ) -RRB- cord-298169-2133gahl 23 34 the the DT cord-298169-2133gahl 23 35 HLA HLA NNP cord-298169-2133gahl 23 36 class class NN cord-298169-2133gahl 23 37 II II NNP cord-298169-2133gahl 23 38 region region NN cord-298169-2133gahl 23 39 encompasses encompass VBZ cord-298169-2133gahl 23 40 the the DT cord-298169-2133gahl 23 41 HLA HLA NNP cord-298169-2133gahl 23 42 - - HYPH cord-298169-2133gahl 23 43 DPA1 DPA1 NNP cord-298169-2133gahl 23 44 , , , cord-298169-2133gahl 23 45 HLA HLA NNP cord-298169-2133gahl 23 46 - - HYPH cord-298169-2133gahl 23 47 DPB1 DPB1 NNP cord-298169-2133gahl 23 48 , , , cord-298169-2133gahl 23 49 HLA HLA NNP cord-298169-2133gahl 23 50 - - HYPH cord-298169-2133gahl 23 51 DQA1 DQA1 NNPS cord-298169-2133gahl 23 52 , , , cord-298169-2133gahl 23 53 HLA HLA NNP cord-298169-2133gahl 23 54 - - HYPH cord-298169-2133gahl 23 55 DQB1 DQB1 NNP cord-298169-2133gahl 23 56 , , , cord-298169-2133gahl 23 57 HLA HLA NNP cord-298169-2133gahl 23 58 - - HYPH cord-298169-2133gahl 23 59 DRA DRA NNP cord-298169-2133gahl 23 60 , , , cord-298169-2133gahl 23 61 HLA HLA NNP cord-298169-2133gahl 23 62 - - HYPH cord-298169-2133gahl 23 63 DRB1 DRB1 NNP cord-298169-2133gahl 23 64 , , , cord-298169-2133gahl 23 65 HLA HLA NNP cord-298169-2133gahl 23 66 - - HYPH cord-298169-2133gahl 23 67 DRB3 DRB3 NNP cord-298169-2133gahl 23 68 , , , cord-298169-2133gahl 23 69 HLA HLA NNP cord-298169-2133gahl 23 70 - - HYPH cord-298169-2133gahl 23 71 DRB4 DRB4 NNP cord-298169-2133gahl 23 72 and and CC cord-298169-2133gahl 23 73 HLA HLA NNP cord-298169-2133gahl 23 74 - - HYPH cord-298169-2133gahl 23 75 DRB5 DRB5 NNP cord-298169-2133gahl 23 76 genes gene NNS cord-298169-2133gahl 23 77 which which WDT cord-298169-2133gahl 23 78 are be VBP cord-298169-2133gahl 23 79 involved involve VBN cord-298169-2133gahl 23 80 in in IN cord-298169-2133gahl 23 81 antigen antigen NN cord-298169-2133gahl 23 82 presentation presentation NN cord-298169-2133gahl 23 83 to to IN cord-298169-2133gahl 23 84 and and CC cord-298169-2133gahl 23 85 iii iii LS cord-298169-2133gahl 23 86 ) ) -RRB- cord-298169-2133gahl 24 1 the the DT cord-298169-2133gahl 24 2 class class NN cord-298169-2133gahl 24 3 III iii CD cord-298169-2133gahl 24 4 region region NN cord-298169-2133gahl 24 5 which which WDT cord-298169-2133gahl 24 6 encompasses encompass VBZ cord-298169-2133gahl 24 7 gene gene NN cord-298169-2133gahl 24 8 loci locus NNS cord-298169-2133gahl 24 9 involved involve VBN cord-298169-2133gahl 24 10 in in IN cord-298169-2133gahl 24 11 inflammatory inflammatory JJ cord-298169-2133gahl 24 12 responses response NNS cord-298169-2133gahl 24 13 , , , cord-298169-2133gahl 24 14 leukocyte leukocyte NN cord-298169-2133gahl 24 15 maturation maturation NN cord-298169-2133gahl 24 16 and and CC cord-298169-2133gahl 24 17 in in IN cord-298169-2133gahl 24 18 the the DT cord-298169-2133gahl 24 19 complement complement NN cord-298169-2133gahl 24 20 cascade cascade NN cord-298169-2133gahl 24 21 . . . cord-298169-2133gahl 25 1 While while IN cord-298169-2133gahl 25 2 the the DT cord-298169-2133gahl 25 3 encoded encode VBN cord-298169-2133gahl 25 4 molecules molecule NNS cord-298169-2133gahl 25 5 of of IN cord-298169-2133gahl 25 6 the the DT cord-298169-2133gahl 25 7 HLA HLA NNP cord-298169-2133gahl 25 8 - - HYPH cord-298169-2133gahl 25 9 A A NNP cord-298169-2133gahl 25 10 , , , cord-298169-2133gahl 25 11 -B -b ADD cord-298169-2133gahl 25 12 and and CC cord-298169-2133gahl 25 13 - - HYPH cord-298169-2133gahl 25 14 C c NN cord-298169-2133gahl 25 15 genes gene NNS cord-298169-2133gahl 25 16 play play VBP cord-298169-2133gahl 25 17 an an DT cord-298169-2133gahl 25 18 essential essential JJ cord-298169-2133gahl 25 19 role role NN cord-298169-2133gahl 25 20 in in IN cord-298169-2133gahl 25 21 the the DT cord-298169-2133gahl 25 22 detection detection NN cord-298169-2133gahl 25 23 and and CC cord-298169-2133gahl 25 24 elimination elimination NN cord-298169-2133gahl 25 25 of of IN cord-298169-2133gahl 25 26 virus virus NN cord-298169-2133gahl 25 27 - - HYPH cord-298169-2133gahl 25 28 infected infect VBN cord-298169-2133gahl 25 29 cells cell NNS cord-298169-2133gahl 25 30 and and CC cord-298169-2133gahl 25 31 tumoral tumoral JJ cord-298169-2133gahl 25 32 cells cell NNS cord-298169-2133gahl 25 33 through through IN cord-298169-2133gahl 25 34 cell cell NN cord-298169-2133gahl 25 35 - - HYPH cord-298169-2133gahl 25 36 mediated mediate VBN cord-298169-2133gahl 25 37 cytotoxic cytotoxic JJ cord-298169-2133gahl 25 38 processes process NNS cord-298169-2133gahl 25 39 , , , cord-298169-2133gahl 25 40 their -PRON- PRP$ cord-298169-2133gahl 25 41 HLA HLA NNP cord-298169-2133gahl 25 42 class class NN cord-298169-2133gahl 25 43 II II NNP cord-298169-2133gahl 25 44 counterparts counterpart NNS cord-298169-2133gahl 25 45 modulate modulate VBP cord-298169-2133gahl 25 46 humoral humoral JJ cord-298169-2133gahl 25 47 immune immune JJ cord-298169-2133gahl 25 48 responses response NNS cord-298169-2133gahl 25 49 ( ( -LRB- cord-298169-2133gahl 25 50 Klein Klein NNP cord-298169-2133gahl 25 51 & & CC cord-298169-2133gahl 25 52 Sato Sato NNP cord-298169-2133gahl 25 53 , , , cord-298169-2133gahl 25 54 2000 2000 CD cord-298169-2133gahl 25 55 ) ) -RRB- cord-298169-2133gahl 25 56 . . . cord-298169-2133gahl 26 1 Both both DT cord-298169-2133gahl 26 2 gene gene NN cord-298169-2133gahl 26 3 sets set NNS cord-298169-2133gahl 26 4 are be VBP cord-298169-2133gahl 26 5 highly highly RB cord-298169-2133gahl 26 6 polymorphic polymorphic JJ cord-298169-2133gahl 26 7 with with IN cord-298169-2133gahl 26 8 more more JJR cord-298169-2133gahl 26 9 than than IN cord-298169-2133gahl 26 10 26.000 26.000 CD cord-298169-2133gahl 26 11 alleles allele NNS cord-298169-2133gahl 26 12 reported report VBN cord-298169-2133gahl 26 13 to to IN cord-298169-2133gahl 26 14 date date NN cord-298169-2133gahl 26 15 , , , cord-298169-2133gahl 26 16 although although IN cord-298169-2133gahl 26 17 each each DT cord-298169-2133gahl 26 18 locus locus NN cord-298169-2133gahl 26 19 has have VBZ cord-298169-2133gahl 26 20 only only RB cord-298169-2133gahl 26 21 around around RB cord-298169-2133gahl 26 22 10 10 CD cord-298169-2133gahl 26 23 to to TO cord-298169-2133gahl 26 24 20 20 CD cord-298169-2133gahl 26 25 dominant dominant JJ cord-298169-2133gahl 26 26 alleles allele NNS cord-298169-2133gahl 26 27 ( ( -LRB- cord-298169-2133gahl 26 28 IMGT IMGT NNP cord-298169-2133gahl 26 29 / / SYM cord-298169-2133gahl 26 30 HLA HLA NNP cord-298169-2133gahl 26 31 Database Database NNP cord-298169-2133gahl 26 32 , , , cord-298169-2133gahl 26 33 2020 2020 CD cord-298169-2133gahl 26 34 ) ) -RRB- cord-298169-2133gahl 26 35 , , , cord-298169-2133gahl 26 36 the the DT cord-298169-2133gahl 26 37 main main JJ cord-298169-2133gahl 26 38 function function NN cord-298169-2133gahl 26 39 of of IN cord-298169-2133gahl 26 40 which which WDT cord-298169-2133gahl 26 41 is be VBZ cord-298169-2133gahl 26 42 to to TO cord-298169-2133gahl 26 43 present present VB cord-298169-2133gahl 26 44 self self NN cord-298169-2133gahl 26 45 or or CC cord-298169-2133gahl 26 46 foreign foreign JJ cord-298169-2133gahl 26 47 antigens antigen NNS cord-298169-2133gahl 26 48 to to IN cord-298169-2133gahl 26 49 T T NNP cord-298169-2133gahl 26 50 cell cell NN cord-298169-2133gahl 26 51 receptors receptor NNS cord-298169-2133gahl 26 52 ( ( -LRB- cord-298169-2133gahl 26 53 TCR TCR NNP cord-298169-2133gahl 26 54 ) ) -RRB- cord-298169-2133gahl 26 55 on on IN cord-298169-2133gahl 26 56 effector effector NN cord-298169-2133gahl 26 57 cells cell NNS cord-298169-2133gahl 26 58 . . . cord-298169-2133gahl 27 1 The the DT cord-298169-2133gahl 27 2 HLA HLA NNP cord-298169-2133gahl 27 3 molecules molecule NNS cord-298169-2133gahl 27 4 have have VBP cord-298169-2133gahl 27 5 long long RB cord-298169-2133gahl 27 6 been be VBN cord-298169-2133gahl 27 7 appreciated appreciate VBN cord-298169-2133gahl 27 8 to to TO cord-298169-2133gahl 27 9 be be VB cord-298169-2133gahl 27 10 involved involve VBN cord-298169-2133gahl 27 11 in in IN cord-298169-2133gahl 27 12 fine fine JJ cord-298169-2133gahl 27 13 tuning tuning NN cord-298169-2133gahl 27 14 of of IN cord-298169-2133gahl 27 15 inflammatory inflammatory JJ cord-298169-2133gahl 27 16 processes process NNS cord-298169-2133gahl 27 17 as as RB cord-298169-2133gahl 27 18 well well RB cord-298169-2133gahl 27 19 as as IN cord-298169-2133gahl 27 20 in in IN cord-298169-2133gahl 27 21 the the DT cord-298169-2133gahl 27 22 development development NN cord-298169-2133gahl 27 23 of of IN cord-298169-2133gahl 27 24 immuno immuno JJ cord-298169-2133gahl 27 25 - - HYPH cord-298169-2133gahl 27 26 mediated mediate VBN cord-298169-2133gahl 27 27 pathophysiological pathophysiological JJ cord-298169-2133gahl 27 28 processes process NNS cord-298169-2133gahl 27 29 including include VBG cord-298169-2133gahl 27 30 autoimmunity autoimmunity NN cord-298169-2133gahl 27 31 , , , cord-298169-2133gahl 27 32 a a DT cord-298169-2133gahl 27 33 frequent frequent JJ cord-298169-2133gahl 27 34 comorbidity comorbidity NN cord-298169-2133gahl 27 35 of of IN cord-298169-2133gahl 27 36 psychiatric psychiatric JJ cord-298169-2133gahl 27 37 disorders disorder NNS cord-298169-2133gahl 27 38 ( ( -LRB- cord-298169-2133gahl 27 39 Khandaker Khandaker NNP cord-298169-2133gahl 27 40 , , , cord-298169-2133gahl 27 41 Dantzer Dantzer NNP cord-298169-2133gahl 27 42 , , , cord-298169-2133gahl 27 43 Jones Jones NNP cord-298169-2133gahl 27 44 et et NNP cord-298169-2133gahl 27 45 al al NNP cord-298169-2133gahl 27 46 , , , cord-298169-2133gahl 27 47 2017 2017 CD cord-298169-2133gahl 27 48 ) ) -RRB- cord-298169-2133gahl 27 49 . . . cord-298169-2133gahl 28 1 Recent recent JJ cord-298169-2133gahl 28 2 data datum NNS cord-298169-2133gahl 28 3 also also RB cord-298169-2133gahl 28 4 show show VBP cord-298169-2133gahl 28 5 that that IN cord-298169-2133gahl 28 6 HLA HLA NNP cord-298169-2133gahl 28 7 molecules molecule NNS cord-298169-2133gahl 28 8 modulate modulate VBP cord-298169-2133gahl 28 9 the the DT cord-298169-2133gahl 28 10 development development NN cord-298169-2133gahl 28 11 and and CC cord-298169-2133gahl 28 12 function function NN cord-298169-2133gahl 28 13 of of IN cord-298169-2133gahl 28 14 the the DT cord-298169-2133gahl 28 15 Central Central NNP cord-298169-2133gahl 28 16 Nervous Nervous NNP cord-298169-2133gahl 28 17 System System NNP cord-298169-2133gahl 28 18 ( ( -LRB- cord-298169-2133gahl 28 19 CNS CNS NNP cord-298169-2133gahl 28 20 ) ) -RRB- cord-298169-2133gahl 28 21 , , , cord-298169-2133gahl 28 22 including include VBG cord-298169-2133gahl 28 23 core core NN cord-298169-2133gahl 28 24 functions function NNS cord-298169-2133gahl 28 25 such such JJ cord-298169-2133gahl 28 26 as as IN cord-298169-2133gahl 28 27 neuronal neuronal JJ cord-298169-2133gahl 28 28 / / SYM cord-298169-2133gahl 28 29 synaptic synaptic JJ cord-298169-2133gahl 28 30 plasticity plasticity NN cord-298169-2133gahl 28 31 , , , cord-298169-2133gahl 28 32 learning learning NN cord-298169-2133gahl 28 33 , , , cord-298169-2133gahl 28 34 memory memory NN cord-298169-2133gahl 28 35 and and CC cord-298169-2133gahl 28 36 behavior behavior NN cord-298169-2133gahl 28 37 ( ( -LRB- cord-298169-2133gahl 28 38 Boulanger Boulanger NNP cord-298169-2133gahl 28 39 , , , cord-298169-2133gahl 28 40 2009 2009 CD cord-298169-2133gahl 28 41 ) ) -RRB- cord-298169-2133gahl 28 42 , , , cord-298169-2133gahl 28 43 as as RB cord-298169-2133gahl 28 44 well well RB cord-298169-2133gahl 28 45 as as IN cord-298169-2133gahl 28 46 more more JJR cord-298169-2133gahl 28 47 direct direct JJ cord-298169-2133gahl 28 48 modulation modulation NN cord-298169-2133gahl 28 49 of of IN cord-298169-2133gahl 28 50 neuron neuron NN cord-298169-2133gahl 28 51 - - HYPH cord-298169-2133gahl 28 52 neuron neuron NN cord-298169-2133gahl 28 53 interactions interaction NNS cord-298169-2133gahl 28 54 and and CC cord-298169-2133gahl 28 55 neuro neuro NNP cord-298169-2133gahl 28 56 - - HYPH cord-298169-2133gahl 28 57 signaling signal VBG cord-298169-2133gahl 28 58 ( ( -LRB- cord-298169-2133gahl 28 59 Sterner Sterner NNP cord-298169-2133gahl 28 60 , , , cord-298169-2133gahl 28 61 Weckle Weckle NNP cord-298169-2133gahl 28 62 , , , cord-298169-2133gahl 28 63 and and CC cord-298169-2133gahl 28 64 Chugani Chugani NNP cord-298169-2133gahl 28 65 , , , cord-298169-2133gahl 28 66 2012 2012 CD cord-298169-2133gahl 28 67 ) ) -RRB- cord-298169-2133gahl 28 68 . . . cord-298169-2133gahl 29 1 The the DT cord-298169-2133gahl 29 2 highest high JJS cord-298169-2133gahl 29 3 HLA HLA NNP cord-298169-2133gahl 29 4 expression expression NN cord-298169-2133gahl 29 5 levels level NNS cord-298169-2133gahl 29 6 are be VBP cord-298169-2133gahl 29 7 detected detect VBN cord-298169-2133gahl 29 8 in in IN cord-298169-2133gahl 29 9 post post JJ cord-298169-2133gahl 29 10 - - JJ cord-298169-2133gahl 29 11 synaptic synaptic JJ cord-298169-2133gahl 29 12 hippocampal hippocampal JJ cord-298169-2133gahl 29 13 neurons neuron NNS cord-298169-2133gahl 29 14 ( ( -LRB- cord-298169-2133gahl 29 15 Goddard Goddard NNP cord-298169-2133gahl 29 16 , , , cord-298169-2133gahl 29 17 Butts Butts NNPS cord-298169-2133gahl 29 18 and and CC cord-298169-2133gahl 29 19 Shatz Shatz NNP cord-298169-2133gahl 29 20 , , , cord-298169-2133gahl 29 21 2007 2007 CD cord-298169-2133gahl 29 22 ) ) -RRB- cord-298169-2133gahl 29 23 . . . cord-298169-2133gahl 30 1 Moreover moreover RB cord-298169-2133gahl 30 2 , , , cord-298169-2133gahl 30 3 the the DT cord-298169-2133gahl 30 4 HLA HLA NNP cord-298169-2133gahl 30 5 molecules molecule NNS cord-298169-2133gahl 30 6 are be VBP cord-298169-2133gahl 30 7 pivotal pivotal JJ cord-298169-2133gahl 30 8 for for IN cord-298169-2133gahl 30 9 the the DT cord-298169-2133gahl 30 10 anatomical anatomical JJ cord-298169-2133gahl 30 11 integrity integrity NN cord-298169-2133gahl 30 12 of of IN cord-298169-2133gahl 30 13 the the DT cord-298169-2133gahl 30 14 CNS CNS NNP cord-298169-2133gahl 30 15 , , , cord-298169-2133gahl 30 16 as as IN cord-298169-2133gahl 30 17 exemplified exemplify VBN cord-298169-2133gahl 30 18 by by IN cord-298169-2133gahl 30 19 the the DT cord-298169-2133gahl 30 20 enlarged enlarge VBN cord-298169-2133gahl 30 21 ventricles ventricle NNS cord-298169-2133gahl 30 22 observed observe VBN cord-298169-2133gahl 30 23 in in IN cord-298169-2133gahl 30 24 HLAclass HLAclass NNP cord-298169-2133gahl 31 1 I -PRON- PRP cord-298169-2133gahl 31 2 deficient deficient JJ cord-298169-2133gahl 31 3 murine murine JJ cord-298169-2133gahl 31 4 models model NNS cord-298169-2133gahl 32 1 ( ( -LRB- cord-298169-2133gahl 32 2 Huh huh UH cord-298169-2133gahl 32 3 et et FW cord-298169-2133gahl 32 4 al al NNP cord-298169-2133gahl 32 5 , , , cord-298169-2133gahl 32 6 2000 2000 CD cord-298169-2133gahl 32 7 ) ) -RRB- cord-298169-2133gahl 32 8 . . . cord-298169-2133gahl 33 1 Despite despite IN cord-298169-2133gahl 33 2 evidence evidence NN cord-298169-2133gahl 33 3 of of IN cord-298169-2133gahl 33 4 prominent prominent JJ cord-298169-2133gahl 33 5 immune immune JJ cord-298169-2133gahl 33 6 implication implication NN cord-298169-2133gahl 33 7 in in IN cord-298169-2133gahl 33 8 a a DT cord-298169-2133gahl 33 9 significant significant JJ cord-298169-2133gahl 33 10 subset subset NN cord-298169-2133gahl 33 11 of of IN cord-298169-2133gahl 33 12 major major JJ cord-298169-2133gahl 33 13 psychiatric psychiatric JJ cord-298169-2133gahl 33 14 disorder disorder NN cord-298169-2133gahl 33 15 patients patient NNS cord-298169-2133gahl 33 16 such such JJ cord-298169-2133gahl 33 17 as as IN cord-298169-2133gahl 33 18 schizophrenia schizophrenia NN cord-298169-2133gahl 33 19 , , , cord-298169-2133gahl 33 20 bipolar bipolar JJ cord-298169-2133gahl 33 21 disorder disorder NN cord-298169-2133gahl 33 22 or or CC cord-298169-2133gahl 33 23 depression depression NN cord-298169-2133gahl 33 24 ( ( -LRB- cord-298169-2133gahl 33 25 Khandaker Khandaker NNP cord-298169-2133gahl 33 26 , , , cord-298169-2133gahl 33 27 Dantzer Dantzer NNP cord-298169-2133gahl 33 28 , , , cord-298169-2133gahl 33 29 Jones Jones NNP cord-298169-2133gahl 33 30 , , , cord-298169-2133gahl 33 31 2017 2017 CD cord-298169-2133gahl 33 32 ) ) -RRB- cord-298169-2133gahl 33 33 or or CC cord-298169-2133gahl 33 34 autism autism NN cord-298169-2133gahl 33 35 spectrum spectrum NN cord-298169-2133gahl 33 36 disorder disorder NN cord-298169-2133gahl 33 37 ( ( -LRB- cord-298169-2133gahl 33 38 Meltzer Meltzer NNP cord-298169-2133gahl 33 39 & & CC cord-298169-2133gahl 33 40 Van Van NNP cord-298169-2133gahl 33 41 de de NNP cord-298169-2133gahl 33 42 Water Water NNP cord-298169-2133gahl 33 43 , , , cord-298169-2133gahl 33 44 2017 2017 CD cord-298169-2133gahl 33 45 ) ) -RRB- cord-298169-2133gahl 33 46 , , , cord-298169-2133gahl 33 47 deciphering decipher VBG cord-298169-2133gahl 33 48 the the DT cord-298169-2133gahl 33 49 mechanistic mechanistic JJ cord-298169-2133gahl 33 50 link link NN cord-298169-2133gahl 33 51 between between IN cord-298169-2133gahl 33 52 the the DT cord-298169-2133gahl 33 53 HLA HLA NNP cord-298169-2133gahl 33 54 system system NN cord-298169-2133gahl 33 55 and and CC cord-298169-2133gahl 33 56 these these DT cord-298169-2133gahl 33 57 disorders disorder NNS cord-298169-2133gahl 33 58 was be VBD cord-298169-2133gahl 33 59 difficult difficult JJ cord-298169-2133gahl 33 60 , , , cord-298169-2133gahl 33 61 primarily primarily RB cord-298169-2133gahl 33 62 because because IN cord-298169-2133gahl 33 63 of of IN cord-298169-2133gahl 33 64 the the DT cord-298169-2133gahl 33 65 complex complex JJ cord-298169-2133gahl 33 66 genetic genetic JJ cord-298169-2133gahl 33 67 architecture architecture NN cord-298169-2133gahl 33 68 of of IN cord-298169-2133gahl 33 69 the the DT cord-298169-2133gahl 33 70 HLA HLA NNP cord-298169-2133gahl 33 71 system system NN cord-298169-2133gahl 33 72 . . . cord-298169-2133gahl 34 1 Recent recent JJ cord-298169-2133gahl 34 2 technological technological JJ cord-298169-2133gahl 34 3 advances advance NNS cord-298169-2133gahl 34 4 now now RB cord-298169-2133gahl 34 5 allow allow VBP cord-298169-2133gahl 34 6 a a DT cord-298169-2133gahl 34 7 more more RBR cord-298169-2133gahl 34 8 precise precise JJ cord-298169-2133gahl 34 9 characterization characterization NN cord-298169-2133gahl 34 10 of of IN cord-298169-2133gahl 34 11 the the DT cord-298169-2133gahl 34 12 HLA HLA NNP cord-298169-2133gahl 34 13 gene gene NN cord-298169-2133gahl 34 14 cluster cluster NN cord-298169-2133gahl 34 15 and and CC cord-298169-2133gahl 34 16 the the DT cord-298169-2133gahl 34 17 identification identification NN cord-298169-2133gahl 34 18 of of IN cord-298169-2133gahl 34 19 its -PRON- PRP$ cord-298169-2133gahl 34 20 etiological etiological JJ cord-298169-2133gahl 34 21 or or CC cord-298169-2133gahl 34 22 protective protective JJ cord-298169-2133gahl 34 23 role role NN cord-298169-2133gahl 34 24 in in IN cord-298169-2133gahl 34 25 psychiatric psychiatric JJ cord-298169-2133gahl 34 26 disorders disorder NNS cord-298169-2133gahl 34 27 . . . cord-298169-2133gahl 35 1 It -PRON- PRP cord-298169-2133gahl 35 2 thus thus RB cord-298169-2133gahl 35 3 timely timely JJ cord-298169-2133gahl 35 4 to to TO cord-298169-2133gahl 35 5 review review VB cord-298169-2133gahl 35 6 the the DT cord-298169-2133gahl 35 7 role role NN cord-298169-2133gahl 35 8 of of IN cord-298169-2133gahl 35 9 HLA HLA NNP cord-298169-2133gahl 35 10 genetics genetic NNS cord-298169-2133gahl 35 11 in in IN cord-298169-2133gahl 35 12 major major JJ cord-298169-2133gahl 35 13 psychiatric psychiatric JJ cord-298169-2133gahl 35 14 disorders disorder NNS cord-298169-2133gahl 35 15 and and CC cord-298169-2133gahl 35 16 to to TO cord-298169-2133gahl 35 17 describe describe VB cord-298169-2133gahl 35 18 future future JJ cord-298169-2133gahl 35 19 research research NN cord-298169-2133gahl 35 20 directions direction NNS cord-298169-2133gahl 35 21 including include VBG cord-298169-2133gahl 35 22 the the DT cord-298169-2133gahl 35 23 regulation regulation NN cord-298169-2133gahl 35 24 of of IN cord-298169-2133gahl 35 25 the the DT cord-298169-2133gahl 35 26 impact impact NN cord-298169-2133gahl 35 27 of of IN cord-298169-2133gahl 35 28 viral viral JJ cord-298169-2133gahl 35 29 infections infection NNS cord-298169-2133gahl 35 30 on on IN cord-298169-2133gahl 35 31 aetiology aetiology NN cord-298169-2133gahl 35 32 and and CC cord-298169-2133gahl 35 33 course course NN cord-298169-2133gahl 35 34 of of IN cord-298169-2133gahl 35 35 psychiatric psychiatric JJ cord-298169-2133gahl 35 36 conditions condition NNS cord-298169-2133gahl 35 37 in in IN cord-298169-2133gahl 35 38 the the DT cord-298169-2133gahl 35 39 context context NN cord-298169-2133gahl 35 40 of of IN cord-298169-2133gahl 35 41 a a DT cord-298169-2133gahl 35 42 world world NN cord-298169-2133gahl 35 43 pandemic pandemic NN cord-298169-2133gahl 35 44 . . . cord-298169-2133gahl 36 1 Since since IN cord-298169-2133gahl 36 2 the the DT cord-298169-2133gahl 36 3 discovery discovery NN cord-298169-2133gahl 36 4 of of IN cord-298169-2133gahl 36 5 the the DT cord-298169-2133gahl 36 6 HLA HLA NNP cord-298169-2133gahl 36 7 system system NN cord-298169-2133gahl 36 8 by by IN cord-298169-2133gahl 36 9 Jean Jean NNP cord-298169-2133gahl 36 10 Dausset Dausset NNP cord-298169-2133gahl 36 11 ( ( -LRB- cord-298169-2133gahl 36 12 Dausset Dausset NNP cord-298169-2133gahl 36 13 and and CC cord-298169-2133gahl 36 14 Brecy Brecy NNP cord-298169-2133gahl 36 15 , , , cord-298169-2133gahl 36 16 1957 1957 CD cord-298169-2133gahl 36 17 ) ) -RRB- cord-298169-2133gahl 36 18 , , , cord-298169-2133gahl 36 19 the the DT cord-298169-2133gahl 36 20 analysis analysis NN cord-298169-2133gahl 36 21 of of IN cord-298169-2133gahl 36 22 HLA HLA NNP cord-298169-2133gahl 36 23 polymorphisms polymorphism NNS cord-298169-2133gahl 36 24 has have VBZ cord-298169-2133gahl 36 25 undergone undergo VBN cord-298169-2133gahl 36 26 successive successive JJ cord-298169-2133gahl 36 27 technological technological JJ cord-298169-2133gahl 36 28 improvements improvement NNS cord-298169-2133gahl 36 29 over over IN cord-298169-2133gahl 36 30 20 20 CD cord-298169-2133gahl 36 31 years year NNS cord-298169-2133gahl 36 32 , , , cord-298169-2133gahl 36 33 leading lead VBG cord-298169-2133gahl 36 34 to to IN cord-298169-2133gahl 36 35 the the DT cord-298169-2133gahl 36 36 gradual gradual JJ cord-298169-2133gahl 36 37 incorporation incorporation NN cord-298169-2133gahl 36 38 of of IN cord-298169-2133gahl 36 39 DNA dna NN cord-298169-2133gahl 36 40 - - HYPH cord-298169-2133gahl 36 41 based base VBN cord-298169-2133gahl 36 42 molecular molecular JJ cord-298169-2133gahl 36 43 approaches approach NNS cord-298169-2133gahl 36 44 , , , cord-298169-2133gahl 36 45 including include VBG cord-298169-2133gahl 36 46 the the DT cord-298169-2133gahl 36 47 high high JJ cord-298169-2133gahl 36 48 throughput throughput NN cord-298169-2133gahl 36 49 and and CC cord-298169-2133gahl 36 50 cost cost NN cord-298169-2133gahl 36 51 - - HYPH cord-298169-2133gahl 36 52 effective effective JJ cord-298169-2133gahl 36 53 Next Next NNP cord-298169-2133gahl 36 54 Generation Generation NNP cord-298169-2133gahl 36 55 Sequencing Sequencing NNP cord-298169-2133gahl 36 56 ( ( -LRB- cord-298169-2133gahl 36 57 NGS NGS NNP cord-298169-2133gahl 36 58 ) ) -RRB- cord-298169-2133gahl 36 59 which which WDT cord-298169-2133gahl 36 60 provides provide VBZ cord-298169-2133gahl 36 61 reliable reliable JJ cord-298169-2133gahl 36 62 and and CC cord-298169-2133gahl 36 63 extensive extensive JJ cord-298169-2133gahl 36 64 HLA HLA NNP cord-298169-2133gahl 36 65 genotyping genotyping NN cord-298169-2133gahl 36 66 . . . cord-298169-2133gahl 37 1 However however RB cord-298169-2133gahl 37 2 , , , cord-298169-2133gahl 37 3 fine fine RB cord-298169-2133gahl 37 4 - - HYPH cord-298169-2133gahl 37 5 tuned tune VBN cord-298169-2133gahl 37 6 analysis analysis NN cord-298169-2133gahl 37 7 and and CC cord-298169-2133gahl 37 8 understanding understanding NN cord-298169-2133gahl 37 9 of of IN cord-298169-2133gahl 37 10 the the DT cord-298169-2133gahl 37 11 HLA HLA NNP cord-298169-2133gahl 37 12 diversity diversity NN cord-298169-2133gahl 37 13 in in IN cord-298169-2133gahl 37 14 genetic genetic JJ cord-298169-2133gahl 37 15 studies study NNS cord-298169-2133gahl 37 16 still still RB cord-298169-2133gahl 37 17 requires require VBZ cord-298169-2133gahl 37 18 specialized specialized JJ cord-298169-2133gahl 37 19 training training NN cord-298169-2133gahl 37 20 either either CC cord-298169-2133gahl 37 21 in in IN cord-298169-2133gahl 37 22 terms term NNS cord-298169-2133gahl 37 23 of of IN cord-298169-2133gahl 37 24 histocompatibility histocompatibility NN cord-298169-2133gahl 37 25 testing testing NN cord-298169-2133gahl 37 26 or or CC cord-298169-2133gahl 37 27 imputation imputation NN cord-298169-2133gahl 37 28 analysis analysis NN cord-298169-2133gahl 37 29 . . . cord-298169-2133gahl 38 1 Despite despite IN cord-298169-2133gahl 38 2 such such JJ cord-298169-2133gahl 38 3 advances advance NNS cord-298169-2133gahl 38 4 and and CC cord-298169-2133gahl 38 5 expertise expertise NN cord-298169-2133gahl 38 6 , , , cord-298169-2133gahl 38 7 HLA HLA NNP cord-298169-2133gahl 38 8 investigation investigation NN cord-298169-2133gahl 38 9 in in IN cord-298169-2133gahl 38 10 disease disease NNP cord-298169-2133gahl 38 11 association association NNP cord-298169-2133gahl 38 12 studies study NNS cord-298169-2133gahl 38 13 still still RB cord-298169-2133gahl 38 14 faces face VBZ cord-298169-2133gahl 38 15 a a DT cord-298169-2133gahl 38 16 number number NN cord-298169-2133gahl 38 17 of of IN cord-298169-2133gahl 38 18 challenges challenge NNS cord-298169-2133gahl 38 19 , , , cord-298169-2133gahl 38 20 including include VBG cord-298169-2133gahl 38 21 : : : cord-298169-2133gahl 38 22 ( ( -LRB- cord-298169-2133gahl 38 23 i i NN cord-298169-2133gahl 38 24 ) ) -RRB- cord-298169-2133gahl 38 25 the the DT cord-298169-2133gahl 38 26 extreme extreme JJ cord-298169-2133gahl 38 27 rate rate NN cord-298169-2133gahl 38 28 of of IN cord-298169-2133gahl 38 29 polymorphism polymorphism NN cord-298169-2133gahl 38 30 ; ; , cord-298169-2133gahl 38 31 ( ( -LRB- cord-298169-2133gahl 38 32 ii ii NN cord-298169-2133gahl 38 33 ) ) -RRB- cord-298169-2133gahl 38 34 the the DT cord-298169-2133gahl 38 35 ethnogeographical ethnogeographical RB cord-298169-2133gahl 38 36 - - HYPH cord-298169-2133gahl 38 37 dependent dependent JJ cord-298169-2133gahl 38 38 distribution distribution NN cord-298169-2133gahl 38 39 of of IN cord-298169-2133gahl 38 40 HLA HLA NNP cord-298169-2133gahl 38 41 alleles allele NNS cord-298169-2133gahl 38 42 ; ; , cord-298169-2133gahl 38 43 ( ( -LRB- cord-298169-2133gahl 38 44 iii iii NN cord-298169-2133gahl 38 45 ) ) -RRB- cord-298169-2133gahl 39 1 the the DT cord-298169-2133gahl 39 2 disease disease NN cord-298169-2133gahl 39 3 - - HYPH cord-298169-2133gahl 39 4 dependent dependent JJ cord-298169-2133gahl 39 5 variable variable JJ cord-298169-2133gahl 39 6 pertinence pertinence NN cord-298169-2133gahl 39 7 of of IN cord-298169-2133gahl 39 8 a a DT cord-298169-2133gahl 39 9 given give VBN cord-298169-2133gahl 39 10 HLA HLA NNP cord-298169-2133gahl 39 11 allele allele NN cord-298169-2133gahl 40 1 e.g. e.g. RB cord-298169-2133gahl 40 2 the the DT cord-298169-2133gahl 40 3 HLA HLA NNP cord-298169-2133gahl 40 4 - - HYPH cord-298169-2133gahl 40 5 B27 B27 NNP cord-298169-2133gahl 40 6 association association NN cord-298169-2133gahl 40 7 is be VBZ cord-298169-2133gahl 40 8 prominently prominently RB cord-298169-2133gahl 40 9 evident evident JJ cord-298169-2133gahl 40 10 for for IN cord-298169-2133gahl 40 11 Ankylosing Ankylosing NNP cord-298169-2133gahl 40 12 Spondylitis Spondylitis NNP cord-298169-2133gahl 40 13 while while IN cord-298169-2133gahl 40 14 for for IN cord-298169-2133gahl 40 15 other other JJ cord-298169-2133gahl 40 16 multi multi JJ cord-298169-2133gahl 40 17 - - JJ cord-298169-2133gahl 40 18 genic genic JJ cord-298169-2133gahl 40 19 and and CC cord-298169-2133gahl 40 20 multifactorial multifactorial JJ cord-298169-2133gahl 40 21 disorders disorder NNS cord-298169-2133gahl 40 22 , , , cord-298169-2133gahl 40 23 evidence evidence NN cord-298169-2133gahl 40 24 of of IN cord-298169-2133gahl 40 25 disease disease NNP cord-298169-2133gahl 40 26 association association NNP cord-298169-2133gahl 40 27 may may MD cord-298169-2133gahl 40 28 not not RB cord-298169-2133gahl 40 29 be be VB cord-298169-2133gahl 40 30 that that RB cord-298169-2133gahl 40 31 apparent apparent JJ cord-298169-2133gahl 40 32 as as IN cord-298169-2133gahl 40 33 distinct distinct JJ cord-298169-2133gahl 40 34 alleles allele NNS cord-298169-2133gahl 40 35 may may MD cord-298169-2133gahl 40 36 have have VB cord-298169-2133gahl 40 37 shared share VBN cord-298169-2133gahl 40 38 functions function NNS cord-298169-2133gahl 40 39 ; ; : cord-298169-2133gahl 40 40 and and CC cord-298169-2133gahl 40 41 ( ( -LRB- cord-298169-2133gahl 40 42 iv iv LS cord-298169-2133gahl 40 43 ) ) -RRB- cord-298169-2133gahl 41 1 the the DT cord-298169-2133gahl 41 2 variability variability NN cord-298169-2133gahl 41 3 of of IN cord-298169-2133gahl 41 4 allele allele NN cord-298169-2133gahl 41 5 expression expression NN cord-298169-2133gahl 41 6 ( ( -LRB- cord-298169-2133gahl 41 7 Ramsuran Ramsuran NNP cord-298169-2133gahl 41 8 et et NNP cord-298169-2133gahl 41 9 al al NNP cord-298169-2133gahl 41 10 , , , cord-298169-2133gahl 41 11 2018 2018 CD cord-298169-2133gahl 41 12 ; ; : cord-298169-2133gahl 41 13 D'Antonio D'Antonio NNP cord-298169-2133gahl 41 14 et et NNP cord-298169-2133gahl 41 15 al al NNP cord-298169-2133gahl 41 16 , , , cord-298169-2133gahl 41 17 2019 2019 CD cord-298169-2133gahl 41 18 ; ; : cord-298169-2133gahl 41 19 Aguiar Aguiar NNP cord-298169-2133gahl 41 20 et et NNP cord-298169-2133gahl 41 21 al al NNP cord-298169-2133gahl 41 22 , , , cord-298169-2133gahl 41 23 2019 2019 CD cord-298169-2133gahl 41 24 ) ) -RRB- cord-298169-2133gahl 41 25 . . . cord-298169-2133gahl 42 1 It -PRON- PRP cord-298169-2133gahl 42 2 thus thus RB cord-298169-2133gahl 42 3 should should MD cord-298169-2133gahl 42 4 be be VB cord-298169-2133gahl 42 5 stressed stress VBN cord-298169-2133gahl 42 6 that that IN cord-298169-2133gahl 42 7 while while IN cord-298169-2133gahl 42 8 the the DT cord-298169-2133gahl 42 9 candidate candidate NN cord-298169-2133gahl 42 10 gene gene NN cord-298169-2133gahl 42 11 approach approach NN cord-298169-2133gahl 42 12 , , , cord-298169-2133gahl 42 13 which which WDT cord-298169-2133gahl 42 14 may may MD cord-298169-2133gahl 42 15 ignore ignore VB cord-298169-2133gahl 42 16 the the DT cord-298169-2133gahl 42 17 degree degree NN cord-298169-2133gahl 42 18 of of IN cord-298169-2133gahl 42 19 contribution contribution NN cord-298169-2133gahl 42 20 of of IN cord-298169-2133gahl 42 21 other other JJ cord-298169-2133gahl 42 22 interacting interact VBG cord-298169-2133gahl 42 23 loci locus NNS cord-298169-2133gahl 42 24 to to IN cord-298169-2133gahl 42 25 the the DT cord-298169-2133gahl 42 26 phenotype phenotype NN cord-298169-2133gahl 42 27 , , , cord-298169-2133gahl 42 28 is be VBZ cord-298169-2133gahl 42 29 not not RB cord-298169-2133gahl 42 30 a a DT cord-298169-2133gahl 42 31 satisfactory satisfactory JJ cord-298169-2133gahl 42 32 way way NN cord-298169-2133gahl 42 33 to to TO cord-298169-2133gahl 42 34 fully fully RB cord-298169-2133gahl 42 35 underscore underscore VB cord-298169-2133gahl 42 36 the the DT cord-298169-2133gahl 42 37 HLA HLA NNP cord-298169-2133gahl 42 38 genetic genetic JJ cord-298169-2133gahl 42 39 diversity diversity NN cord-298169-2133gahl 42 40 , , , cord-298169-2133gahl 42 41 Genome Genome NNP cord-298169-2133gahl 42 42 - - HYPH cord-298169-2133gahl 42 43 Wide Wide NNP cord-298169-2133gahl 42 44 Association Association NNP cord-298169-2133gahl 42 45 Studies Studies NNPS cord-298169-2133gahl 42 46 ( ( -LRB- cord-298169-2133gahl 42 47 GWAS GWAS NNP cord-298169-2133gahl 42 48 ) ) -RRB- cord-298169-2133gahl 42 49 followed follow VBN cord-298169-2133gahl 42 50 by by IN cord-298169-2133gahl 42 51 HLA HLA NNP cord-298169-2133gahl 42 52 imputation imputation NN cord-298169-2133gahl 42 53 - - HYPH cord-298169-2133gahl 42 54 based base VBN cord-298169-2133gahl 42 55 methods method NNS cord-298169-2133gahl 42 56 , , , cord-298169-2133gahl 42 57 at at IN cord-298169-2133gahl 42 58 least least JJS cord-298169-2133gahl 42 59 in in IN cord-298169-2133gahl 42 60 Caucasian caucasian JJ cord-298169-2133gahl 42 61 and and CC cord-298169-2133gahl 42 62 Asians Asians NNPS cord-298169-2133gahl 42 63 , , , cord-298169-2133gahl 42 64 may may MD cord-298169-2133gahl 42 65 provide provide VB cord-298169-2133gahl 42 66 clues clue NNS cord-298169-2133gahl 42 67 towards towards IN cord-298169-2133gahl 42 68 understanding understand VBG cord-298169-2133gahl 42 69 the the DT cord-298169-2133gahl 42 70 HLA HLA NNP cord-298169-2133gahl 42 71 genetic genetic JJ cord-298169-2133gahl 42 72 contribution contribution NN cord-298169-2133gahl 42 73 to to IN cord-298169-2133gahl 42 74 psychiatric psychiatric JJ cord-298169-2133gahl 42 75 disorders disorder NNS cord-298169-2133gahl 42 76 . . . cord-298169-2133gahl 43 1 Unfortunately unfortunately RB cord-298169-2133gahl 43 2 , , , cord-298169-2133gahl 43 3 at at IN cord-298169-2133gahl 43 4 the the DT cord-298169-2133gahl 43 5 present present JJ cord-298169-2133gahl 43 6 time time NN cord-298169-2133gahl 43 7 , , , cord-298169-2133gahl 43 8 only only RB cord-298169-2133gahl 43 9 few few JJ cord-298169-2133gahl 43 10 post post JJ cord-298169-2133gahl 43 11 - - JJ cord-298169-2133gahl 43 12 GWAS GWAS NNP cord-298169-2133gahl 43 13 HLA HLA NNP cord-298169-2133gahl 43 14 imputation imputation NN cord-298169-2133gahl 43 15 - - HYPH cord-298169-2133gahl 43 16 based base VBN cord-298169-2133gahl 43 17 studies study NNS cord-298169-2133gahl 43 18 have have VBP cord-298169-2133gahl 43 19 been be VBN cord-298169-2133gahl 43 20 undertaken undertake VBN cord-298169-2133gahl 43 21 . . . cord-298169-2133gahl 44 1 An an DT cord-298169-2133gahl 44 2 approach approach NN cord-298169-2133gahl 44 3 to to TO cord-298169-2133gahl 44 4 overcome overcome VB cord-298169-2133gahl 44 5 these these DT cord-298169-2133gahl 44 6 difficulties difficulty NNS cord-298169-2133gahl 44 7 is be VBZ cord-298169-2133gahl 44 8 to to TO cord-298169-2133gahl 44 9 understand understand VB cord-298169-2133gahl 44 10 the the DT cord-298169-2133gahl 44 11 evolution evolution NN cord-298169-2133gahl 44 12 - - HYPH cord-298169-2133gahl 44 13 based base VBN cord-298169-2133gahl 44 14 shaping shaping NN cord-298169-2133gahl 44 15 of of IN cord-298169-2133gahl 44 16 present present JJ cord-298169-2133gahl 44 17 - - HYPH cord-298169-2133gahl 44 18 day day NN cord-298169-2133gahl 44 19 HLA HLA NNP cord-298169-2133gahl 44 20 diversity diversity NN cord-298169-2133gahl 44 21 as as IN cord-298169-2133gahl 44 22 stemming stem VBG cord-298169-2133gahl 44 23 from from IN cord-298169-2133gahl 44 24 a a DT cord-298169-2133gahl 44 25 limited limited JJ cord-298169-2133gahl 44 26 , , , cord-298169-2133gahl 44 27 but but CC cord-298169-2133gahl 44 28 manageable manageable JJ cord-298169-2133gahl 44 29 , , , cord-298169-2133gahl 44 30 number number NN cord-298169-2133gahl 44 31 of of IN cord-298169-2133gahl 44 32 Ancestral Ancestral NNP cord-298169-2133gahl 44 33 Haplotypes Haplotypes NNP cord-298169-2133gahl 44 34 ( ( -LRB- cord-298169-2133gahl 44 35 AH AH NNP cord-298169-2133gahl 44 36 ) ) -RRB- cord-298169-2133gahl 44 37 . . . cord-298169-2133gahl 45 1 Various various JJ cord-298169-2133gahl 45 2 genetic genetic JJ cord-298169-2133gahl 45 3 events event NNS cord-298169-2133gahl 45 4 , , , cord-298169-2133gahl 45 5 viz viz NN cord-298169-2133gahl 45 6 crossing crossing NN cord-298169-2133gahl 45 7 - - HYPH cord-298169-2133gahl 45 8 overs over NNS cord-298169-2133gahl 45 9 , , , cord-298169-2133gahl 45 10 recombination recombination NN cord-298169-2133gahl 45 11 and and CC cord-298169-2133gahl 45 12 point point NN cord-298169-2133gahl 45 13 mutations mutation NNS cord-298169-2133gahl 45 14 , , , cord-298169-2133gahl 45 15 have have VBP cord-298169-2133gahl 45 16 participated participate VBN cord-298169-2133gahl 45 17 in in IN cord-298169-2133gahl 45 18 that that DT cord-298169-2133gahl 45 19 evolution evolution NN cord-298169-2133gahl 46 1 ( ( -LRB- cord-298169-2133gahl 46 2 Price price NN cord-298169-2133gahl 46 3 et et NNP cord-298169-2133gahl 46 4 al al NNP cord-298169-2133gahl 46 5 , , , cord-298169-2133gahl 46 6 1999 1999 CD cord-298169-2133gahl 46 7 ; ; : cord-298169-2133gahl 46 8 Dawkins Dawkins NNP cord-298169-2133gahl 46 9 et et NNP cord-298169-2133gahl 46 10 al al NNP cord-298169-2133gahl 46 11 , , , cord-298169-2133gahl 46 12 1999 1999 CD cord-298169-2133gahl 46 13 ) ) -RRB- cord-298169-2133gahl 46 14 . . . cord-298169-2133gahl 47 1 These these DT cord-298169-2133gahl 47 2 AHs ah NNS cord-298169-2133gahl 47 3 were be VBD cord-298169-2133gahl 47 4 selected select VBN cord-298169-2133gahl 47 5 under under IN cord-298169-2133gahl 47 6 diverse diverse JJ cord-298169-2133gahl 47 7 geographic geographic JJ cord-298169-2133gahl 47 8 - - HYPH cord-298169-2133gahl 47 9 specific specific JJ cord-298169-2133gahl 47 10 environmental environmental JJ cord-298169-2133gahl 47 11 pressures pressure NNS cord-298169-2133gahl 47 12 , , , cord-298169-2133gahl 47 13 then then RB cord-298169-2133gahl 47 14 conserved conserve VBN cord-298169-2133gahl 47 15 and and CC cord-298169-2133gahl 47 16 fully fully RB cord-298169-2133gahl 47 17 or or CC cord-298169-2133gahl 47 18 partially partially RB cord-298169-2133gahl 47 19 transmitted transmit VBN cord-298169-2133gahl 47 20 to to IN cord-298169-2133gahl 47 21 successive successive JJ cord-298169-2133gahl 47 22 generations generation NNS cord-298169-2133gahl 48 1 ( ( -LRB- cord-298169-2133gahl 48 2 Dawkins Dawkins NNP cord-298169-2133gahl 48 3 et et NNP cord-298169-2133gahl 48 4 al al NNP cord-298169-2133gahl 48 5 , , , cord-298169-2133gahl 48 6 1999 1999 CD cord-298169-2133gahl 48 7 ) ) -RRB- cord-298169-2133gahl 48 8 . . . cord-298169-2133gahl 49 1 Consequently consequently RB cord-298169-2133gahl 49 2 , , , cord-298169-2133gahl 49 3 study study NN cord-298169-2133gahl 49 4 of of IN cord-298169-2133gahl 49 5 AH AH NNP cord-298169-2133gahl 49 6 distribution distribution NN cord-298169-2133gahl 49 7 in in IN cord-298169-2133gahl 49 8 disease disease NNP cord-298169-2133gahl 49 9 association association NNP cord-298169-2133gahl 49 10 studies study NNS cord-298169-2133gahl 49 11 have have VBP cord-298169-2133gahl 49 12 clarified clarify VBN cord-298169-2133gahl 49 13 why why WRB cord-298169-2133gahl 49 14 apparently apparently RB cord-298169-2133gahl 49 15 distinct distinct JJ cord-298169-2133gahl 49 16 HLA HLA NNP cord-298169-2133gahl 49 17 alleles allele NNS cord-298169-2133gahl 49 18 exhibit exhibit VBP cord-298169-2133gahl 49 19 association association NN cord-298169-2133gahl 49 20 with with IN cord-298169-2133gahl 49 21 a a DT cord-298169-2133gahl 49 22 given give VBN cord-298169-2133gahl 49 23 disorder disorder NN cord-298169-2133gahl 49 24 . . . cord-298169-2133gahl 50 1 Indeed indeed RB cord-298169-2133gahl 50 2 , , , cord-298169-2133gahl 50 3 these these DT cord-298169-2133gahl 50 4 alleles allele NNS cord-298169-2133gahl 50 5 , , , cord-298169-2133gahl 50 6 linked link VBN cord-298169-2133gahl 50 7 to to IN cord-298169-2133gahl 50 8 AHs ah NNS cord-298169-2133gahl 50 9 , , , cord-298169-2133gahl 50 10 allow allow VB cord-298169-2133gahl 50 11 to to TO cord-298169-2133gahl 50 12 stratify stratify VB cord-298169-2133gahl 50 13 the the DT cord-298169-2133gahl 50 14 patients patient NNS cord-298169-2133gahl 50 15 into into IN cord-298169-2133gahl 50 16 an an DT cord-298169-2133gahl 50 17 immuno immuno JJ cord-298169-2133gahl 50 18 - - HYPH cord-298169-2133gahl 50 19 inflammatory inflammatory JJ cord-298169-2133gahl 50 20 subset subset NN cord-298169-2133gahl 50 21 for for IN cord-298169-2133gahl 50 22 AH AH NNP cord-298169-2133gahl 50 23 associated associate VBN cord-298169-2133gahl 50 24 with with IN cord-298169-2133gahl 50 25 steady steady JJ cord-298169-2133gahl 50 26 state state NN cord-298169-2133gahl 50 27 inflammation inflammation NN cord-298169-2133gahl 50 28 even even RB cord-298169-2133gahl 50 29 among among IN cord-298169-2133gahl 50 30 healthy healthy JJ cord-298169-2133gahl 50 31 subjects subject NNS cord-298169-2133gahl 50 32 . . . cord-298169-2133gahl 51 1 For for IN cord-298169-2133gahl 51 2 example example NN cord-298169-2133gahl 51 3 , , , cord-298169-2133gahl 51 4 HLA-8.1AH HLA-8.1AH NNP cord-298169-2133gahl 51 5 is be VBZ cord-298169-2133gahl 51 6 the the DT cord-298169-2133gahl 51 7 most most RBS cord-298169-2133gahl 51 8 associated associated JJ cord-298169-2133gahl 51 9 AH AH NNP cord-298169-2133gahl 51 10 with with IN cord-298169-2133gahl 51 11 immune immune NN cord-298169-2133gahl 51 12 - - HYPH cord-298169-2133gahl 51 13 related relate VBN cord-298169-2133gahl 51 14 disorders disorder NNS cord-298169-2133gahl 51 15 , , , cord-298169-2133gahl 51 16 including include VBG cord-298169-2133gahl 51 17 infections infection NNS cord-298169-2133gahl 51 18 and and CC cord-298169-2133gahl 51 19 autoimmunity autoimmunity NN cord-298169-2133gahl 51 20 , , , cord-298169-2133gahl 51 21 whilst whilst IN cord-298169-2133gahl 51 22 also also RB cord-298169-2133gahl 51 23 being be VBG cord-298169-2133gahl 51 24 characterized characterize VBN cord-298169-2133gahl 51 25 by by IN cord-298169-2133gahl 51 26 a a DT cord-298169-2133gahl 51 27 steady steady JJ cord-298169-2133gahl 51 28 state state NN cord-298169-2133gahl 51 29 pro pro JJ cord-298169-2133gahl 51 30 - - JJ cord-298169-2133gahl 51 31 inflammatory inflammatory JJ cord-298169-2133gahl 51 32 background background NN cord-298169-2133gahl 51 33 in in IN cord-298169-2133gahl 51 34 healthy healthy JJ cord-298169-2133gahl 51 35 individuals individual NNS cord-298169-2133gahl 51 36 ( ( -LRB- cord-298169-2133gahl 51 37 Price price NN cord-298169-2133gahl 51 38 et et FW cord-298169-2133gahl 51 39 al al NNP cord-298169-2133gahl 51 40 , , , cord-298169-2133gahl 51 41 1999 1999 CD cord-298169-2133gahl 51 42 ; ; : cord-298169-2133gahl 51 43 Giambino Giambino NNP cord-298169-2133gahl 51 44 et et NNP cord-298169-2133gahl 51 45 al al NNP cord-298169-2133gahl 51 46 , , , cord-298169-2133gahl 51 47 2018 2018 CD cord-298169-2133gahl 51 48 ) ) -RRB- cord-298169-2133gahl 51 49 . . . cord-298169-2133gahl 52 1 Such such JJ cord-298169-2133gahl 52 2 properties property NNS cord-298169-2133gahl 52 3 may may MD cord-298169-2133gahl 52 4 explain explain VB cord-298169-2133gahl 52 5 why why WRB cord-298169-2133gahl 52 6 the the DT cord-298169-2133gahl 52 7 8.1AH 8.1ah CD cord-298169-2133gahl 52 8 can can MD cord-298169-2133gahl 52 9 be be VB cord-298169-2133gahl 52 10 protective protective JJ cord-298169-2133gahl 52 11 against against IN cord-298169-2133gahl 52 12 pathogens pathogen NNS cord-298169-2133gahl 52 13 and and CC cord-298169-2133gahl 52 14 therefore therefore RB cord-298169-2133gahl 52 15 positively positively RB cord-298169-2133gahl 52 16 selected select VBN cord-298169-2133gahl 52 17 , , , cord-298169-2133gahl 52 18 while while IN cord-298169-2133gahl 52 19 also also RB cord-298169-2133gahl 52 20 having have VBG cord-298169-2133gahl 52 21 a a DT cord-298169-2133gahl 52 22 negative negative JJ cord-298169-2133gahl 52 23 health health NN cord-298169-2133gahl 52 24 impact impact NN cord-298169-2133gahl 52 25 due due IN cord-298169-2133gahl 52 26 to to IN cord-298169-2133gahl 52 27 the the DT cord-298169-2133gahl 52 28 association association NN cord-298169-2133gahl 52 29 of of IN cord-298169-2133gahl 52 30 chronic chronic NNP cord-298169-2133gahl 52 31 pro pro JJ cord-298169-2133gahl 52 32 - - JJ cord-298169-2133gahl 52 33 inflammatory inflammatory JJ cord-298169-2133gahl 52 34 status status NN cord-298169-2133gahl 52 35 with with IN cord-298169-2133gahl 52 36 high high JJ cord-298169-2133gahl 52 37 risk risk NN cord-298169-2133gahl 52 38 for for IN cord-298169-2133gahl 52 39 autoimmunity autoimmunity NN cord-298169-2133gahl 52 40 ( ( -LRB- cord-298169-2133gahl 52 41 Crespy Crespy NNP cord-298169-2133gahl 52 42 and and CC cord-298169-2133gahl 52 43 Go go VB cord-298169-2133gahl 52 44 , , , cord-298169-2133gahl 52 45 2015 2015 CD cord-298169-2133gahl 52 46 ) ) -RRB- cord-298169-2133gahl 52 47 . . . cord-298169-2133gahl 53 1 HLA HLA NNP cord-298169-2133gahl 53 2 functional functional JJ cord-298169-2133gahl 53 3 diversity diversity NN cord-298169-2133gahl 53 4 can can MD cord-298169-2133gahl 53 5 also also RB cord-298169-2133gahl 53 6 be be VB cord-298169-2133gahl 53 7 investigated investigate VBN cord-298169-2133gahl 53 8 via via IN cord-298169-2133gahl 53 9 allele allele NN cord-298169-2133gahl 53 10 - - HYPH cord-298169-2133gahl 53 11 dependent dependent JJ cord-298169-2133gahl 53 12 expression expression NN cord-298169-2133gahl 53 13 status status NN cord-298169-2133gahl 53 14 which which WDT cord-298169-2133gahl 53 15 reflects reflect VBZ cord-298169-2133gahl 53 16 the the DT cord-298169-2133gahl 53 17 influence influence NN cord-298169-2133gahl 53 18 of of IN cord-298169-2133gahl 53 19 HLA HLA NNP cord-298169-2133gahl 53 20 alleles allele NNS cord-298169-2133gahl 53 21 per per FW cord-298169-2133gahl 53 22 se se FW cord-298169-2133gahl 53 23 . . . cord-298169-2133gahl 54 1 For for IN cord-298169-2133gahl 54 2 example example NN cord-298169-2133gahl 54 3 , , , cord-298169-2133gahl 54 4 single single JJ cord-298169-2133gahl 54 5 nucleotide nucleotide JJ cord-298169-2133gahl 54 6 polymorphisms polymorphism NNS cord-298169-2133gahl 54 7 ( ( -LRB- cord-298169-2133gahl 54 8 SNP SNP NNP cord-298169-2133gahl 54 9 ) ) -RRB- cord-298169-2133gahl 54 10 categorize categorize VBP cord-298169-2133gahl 54 11 the the DT cord-298169-2133gahl 54 12 HLA HLA NNP cord-298169-2133gahl 54 13 - - HYPH cord-298169-2133gahl 54 14 DPB1 DPB1 NNP cord-298169-2133gahl 54 15 and and CC cord-298169-2133gahl 54 16 HLA HLA NNP cord-298169-2133gahl 54 17 - - HYPH cord-298169-2133gahl 54 18 C C NNP cord-298169-2133gahl 54 19 alleles allele NNS cord-298169-2133gahl 54 20 into into IN cord-298169-2133gahl 54 21 highly highly RB cord-298169-2133gahl 54 22 and and CC cord-298169-2133gahl 54 23 lowly lowly JJ cord-298169-2133gahl 54 24 expressed express VBN cord-298169-2133gahl 54 25 variants variant NNS cord-298169-2133gahl 54 26 ( ( -LRB- cord-298169-2133gahl 54 27 Petersdorf Petersdorf NNP cord-298169-2133gahl 54 28 et et NNP cord-298169-2133gahl 54 29 al al NNP cord-298169-2133gahl 54 30 , , , cord-298169-2133gahl 54 31 2015 2015 CD cord-298169-2133gahl 54 32 ; ; : cord-298169-2133gahl 54 33 Thomas Thomas NNP cord-298169-2133gahl 54 34 et et NNP cord-298169-2133gahl 54 35 al al NNP cord-298169-2133gahl 54 36 , , , cord-298169-2133gahl 54 37 2009 2009 CD cord-298169-2133gahl 54 38 ; ; : cord-298169-2133gahl 54 39 Apps Apps NNP cord-298169-2133gahl 54 40 et et NNP cord-298169-2133gahl 54 41 al al NNP cord-298169-2133gahl 54 42 , , , cord-298169-2133gahl 54 43 2013 2013 CD cord-298169-2133gahl 54 44 ) ) -RRB- cord-298169-2133gahl 54 45 . . . cord-298169-2133gahl 55 1 HLA HLA NNP cord-298169-2133gahl 55 2 - - HYPH cord-298169-2133gahl 55 3 peptide peptide NN cord-298169-2133gahl 55 4 combination combination NN cord-298169-2133gahl 55 5 is be VBZ cord-298169-2133gahl 55 6 mediated mediate VBN cord-298169-2133gahl 55 7 by by IN cord-298169-2133gahl 55 8 the the DT cord-298169-2133gahl 55 9 polymorphic polymorphic JJ cord-298169-2133gahl 55 10 TCRs tcr NNS cord-298169-2133gahl 55 11 on on IN cord-298169-2133gahl 55 12 CD8 CD8 NNP cord-298169-2133gahl 55 13 + + CC cord-298169-2133gahl 55 14 T T NNP cord-298169-2133gahl 55 15 cells cell NNS cord-298169-2133gahl 55 16 , , , cord-298169-2133gahl 55 17 which which WDT cord-298169-2133gahl 55 18 bind bind VBP cord-298169-2133gahl 55 19 class class NN cord-298169-2133gahl 55 20 I -PRON- PRP cord-298169-2133gahl 55 21 molecules molecule NNS cord-298169-2133gahl 55 22 , , , cord-298169-2133gahl 55 23 and and CC cord-298169-2133gahl 55 24 on on IN cord-298169-2133gahl 55 25 CD4 CD4 NNP cord-298169-2133gahl 55 26 + + CC cord-298169-2133gahl 55 27 T t NN cord-298169-2133gahl 55 28 cells cell NNS cord-298169-2133gahl 55 29 which which WDT cord-298169-2133gahl 55 30 bind bind VBP cord-298169-2133gahl 55 31 class class NN cord-298169-2133gahl 55 32 II ii CD cord-298169-2133gahl 55 33 molecules molecule NNS cord-298169-2133gahl 55 34 . . . cord-298169-2133gahl 56 1 The the DT cord-298169-2133gahl 56 2 specificity specificity NN cord-298169-2133gahl 56 3 of of IN cord-298169-2133gahl 56 4 HLA HLA NNP cord-298169-2133gahl 56 5 - - HYPH cord-298169-2133gahl 56 6 peptide peptide NN cord-298169-2133gahl 56 7 - - HYPH cord-298169-2133gahl 56 8 TCR TCR NNP cord-298169-2133gahl 56 9 tripartite tripartite JJ cord-298169-2133gahl 56 10 interactions interaction NNS cord-298169-2133gahl 56 11 is be VBZ cord-298169-2133gahl 56 12 fundamental fundamental JJ cord-298169-2133gahl 56 13 in in IN cord-298169-2133gahl 56 14 enabling enable VBG cord-298169-2133gahl 56 15 the the DT cord-298169-2133gahl 56 16 adaptive adaptive JJ cord-298169-2133gahl 56 17 immune immune JJ cord-298169-2133gahl 56 18 system system NN cord-298169-2133gahl 56 19 to to TO cord-298169-2133gahl 56 20 mount mount VB cord-298169-2133gahl 56 21 an an DT cord-298169-2133gahl 56 22 efficient efficient JJ cord-298169-2133gahl 56 23 and and CC cord-298169-2133gahl 56 24 appropriate appropriate JJ cord-298169-2133gahl 56 25 response response NN cord-298169-2133gahl 56 26 against against IN cord-298169-2133gahl 56 27 infection infection NN cord-298169-2133gahl 56 28 , , , cord-298169-2133gahl 56 29 whilst whilst IN cord-298169-2133gahl 56 30 simultaneously simultaneously RB cord-298169-2133gahl 56 31 preventing prevent VBG cord-298169-2133gahl 56 32 auto auto NN cord-298169-2133gahl 56 33 - - HYPH cord-298169-2133gahl 56 34 immune immune JJ cord-298169-2133gahl 56 35 processes process NNS cord-298169-2133gahl 56 36 ( ( -LRB- cord-298169-2133gahl 56 37 Creusot Creusot NNP cord-298169-2133gahl 56 38 , , , cord-298169-2133gahl 56 39 Mitchison Mitchison NNP cord-298169-2133gahl 56 40 , , , cord-298169-2133gahl 56 41 Terazzini Terazzini NNP cord-298169-2133gahl 56 42 , , , cord-298169-2133gahl 56 43 2002 2002 CD cord-298169-2133gahl 56 44 ; ; : cord-298169-2133gahl 56 45 Woodsworth Woodsworth NNP cord-298169-2133gahl 56 46 , , , cord-298169-2133gahl 56 47 Castellarin Castellarin NNP cord-298169-2133gahl 56 48 and and CC cord-298169-2133gahl 56 49 Holt Holt NNP cord-298169-2133gahl 56 50 , , , cord-298169-2133gahl 56 51 2013 2013 CD cord-298169-2133gahl 56 52 ; ; : cord-298169-2133gahl 56 53 _SP cord-298169-2133gahl 56 54 Morris Morris NNP cord-298169-2133gahl 56 55 and and CC cord-298169-2133gahl 56 56 Allen Allen NNP cord-298169-2133gahl 56 57 , , , cord-298169-2133gahl 56 58 2012 2012 CD cord-298169-2133gahl 56 59 ) ) -RRB- cord-298169-2133gahl 56 60 . . . cord-298169-2133gahl 57 1 Different different JJ cord-298169-2133gahl 57 2 mechanisms mechanism NNS cord-298169-2133gahl 57 3 may may MD cord-298169-2133gahl 57 4 underpin underpin VB cord-298169-2133gahl 57 5 HLA HLA NNP cord-298169-2133gahl 57 6 associated associate VBN cord-298169-2133gahl 57 7 diseases disease NNS cord-298169-2133gahl 57 8 , , , cord-298169-2133gahl 57 9 including include VBG cord-298169-2133gahl 57 10 : : : cord-298169-2133gahl 57 11 1 1 LS cord-298169-2133gahl 57 12 ) ) -RRB- cord-298169-2133gahl 57 13 atypical atypical JJ cord-298169-2133gahl 57 14 HLA HLA NNP cord-298169-2133gahl 57 15 - - HYPH cord-298169-2133gahl 57 16 peptide peptide NN cord-298169-2133gahl 57 17 - - HYPH cord-298169-2133gahl 57 18 TCR TCR NNP cord-298169-2133gahl 57 19 binding binding NN cord-298169-2133gahl 57 20 orientation orientation NN cord-298169-2133gahl 57 21 ; ; : cord-298169-2133gahl 57 22 2 2 LS cord-298169-2133gahl 57 23 ) ) -RRB- cord-298169-2133gahl 57 24 low low JJ cord-298169-2133gahl 57 25 affinity affinity NN cord-298169-2133gahl 57 26 peptide peptide NN cord-298169-2133gahl 57 27 binding binding NN cord-298169-2133gahl 57 28 that that WDT cord-298169-2133gahl 57 29 facilitates facilitate VBZ cord-298169-2133gahl 57 30 thymic thymic JJ cord-298169-2133gahl 57 31 escape escape NN cord-298169-2133gahl 57 32 ; ; : cord-298169-2133gahl 57 33 3 3 LS cord-298169-2133gahl 57 34 ) ) -RRB- cord-298169-2133gahl 57 35 TCR TCR NNP cord-298169-2133gahl 57 36 - - HYPH cord-298169-2133gahl 57 37 mediated mediate VBN cord-298169-2133gahl 57 38 stabilization stabilization NN cord-298169-2133gahl 57 39 of of IN cord-298169-2133gahl 57 40 weak weak JJ cord-298169-2133gahl 57 41 - - HYPH cord-298169-2133gahl 57 42 peptide peptide NN cord-298169-2133gahl 57 43 - - HYPH cord-298169-2133gahl 57 44 HLA hla NN cord-298169-2133gahl 57 45 - - HYPH cord-298169-2133gahl 57 46 interaction interaction NN cord-298169-2133gahl 57 47 ; ; : cord-298169-2133gahl 57 48 and and CC cord-298169-2133gahl 57 49 4 4 LS cord-298169-2133gahl 57 50 ) ) -RRB- cord-298169-2133gahl 57 51 presentation presentation NN cord-298169-2133gahl 57 52 of of IN cord-298169-2133gahl 57 53 peptides peptide NNS cord-298169-2133gahl 57 54 in in IN cord-298169-2133gahl 57 55 a a DT cord-298169-2133gahl 57 56 different different JJ cord-298169-2133gahl 57 57 binding binding NN cord-298169-2133gahl 57 58 register register NN cord-298169-2133gahl 57 59 . . . cord-298169-2133gahl 58 1 Other other JJ cord-298169-2133gahl 58 2 mechanisms mechanism NNS cord-298169-2133gahl 58 3 that that WDT cord-298169-2133gahl 58 4 may may MD cord-298169-2133gahl 58 5 generate generate VB cord-298169-2133gahl 58 6 autoreactive autoreactive JJ cord-298169-2133gahl 58 7 T t NN cord-298169-2133gahl 58 8 cells cell NNS cord-298169-2133gahl 58 9 are be VBP cord-298169-2133gahl 58 10 driven drive VBN cord-298169-2133gahl 58 11 by by IN cord-298169-2133gahl 58 12 epitope epitope NN cord-298169-2133gahl 58 13 variation variation NN cord-298169-2133gahl 58 14 , , , cord-298169-2133gahl 58 15 including include VBG cord-298169-2133gahl 58 16 molecular molecular JJ cord-298169-2133gahl 58 17 mimicry mimicry NN cord-298169-2133gahl 58 18 ( ( -LRB- cord-298169-2133gahl 58 19 Yin Yin NNP cord-298169-2133gahl 58 20 , , , cord-298169-2133gahl 58 21 Li Li NNP cord-298169-2133gahl 58 22 and and CC cord-298169-2133gahl 58 23 Mariuzza Mariuzza NNP cord-298169-2133gahl 58 24 , , , cord-298169-2133gahl 58 25 2012 2012 CD cord-298169-2133gahl 58 26 ) ) -RRB- cord-298169-2133gahl 58 27 . . . cord-298169-2133gahl 59 1 Thus thus RB cord-298169-2133gahl 59 2 , , , cord-298169-2133gahl 59 3 while while IN cord-298169-2133gahl 59 4 GWAS GWAS NNP cord-298169-2133gahl 59 5 identified identify VBD cord-298169-2133gahl 59 6 the the DT cord-298169-2133gahl 59 7 MHC MHC NNP cord-298169-2133gahl 59 8 / / SYM cord-298169-2133gahl 59 9 HLA HLA NNP cord-298169-2133gahl 59 10 genetic genetic JJ cord-298169-2133gahl 59 11 cluster cluster NN cord-298169-2133gahl 59 12 as as IN cord-298169-2133gahl 59 13 being be VBG cord-298169-2133gahl 59 14 a a DT cord-298169-2133gahl 59 15 pivotal pivotal JJ cord-298169-2133gahl 59 16 region region NN cord-298169-2133gahl 59 17 , , , cord-298169-2133gahl 59 18 specific specific JJ cord-298169-2133gahl 59 19 HLA HLA NNP cord-298169-2133gahl 59 20 - - HYPH cord-298169-2133gahl 59 21 dedicated dedicated JJ cord-298169-2133gahl 59 22 expertise expertise NN cord-298169-2133gahl 59 23 started start VBD cord-298169-2133gahl 59 24 to to TO cord-298169-2133gahl 59 25 uncover uncover VB cord-298169-2133gahl 59 26 meaningful meaningful JJ cord-298169-2133gahl 59 27 functional functional JJ cord-298169-2133gahl 59 28 haplotypes haplotype NNS cord-298169-2133gahl 59 29 associated associate VBN cord-298169-2133gahl 59 30 with with IN cord-298169-2133gahl 59 31 specific specific JJ cord-298169-2133gahl 59 32 psychiatric psychiatric JJ cord-298169-2133gahl 59 33 entities entity NNS cord-298169-2133gahl 59 34 . . . cord-298169-2133gahl 60 1 HLA HLA NNP cord-298169-2133gahl 60 2 analysis analysis NN cord-298169-2133gahl 60 3 in in IN cord-298169-2133gahl 60 4 psychiatric psychiatric JJ cord-298169-2133gahl 60 5 disorders disorder NNS cord-298169-2133gahl 60 6 will will MD cord-298169-2133gahl 60 7 help help VB cord-298169-2133gahl 60 8 not not RB cord-298169-2133gahl 60 9 only only RB cord-298169-2133gahl 60 10 to to TO cord-298169-2133gahl 60 11 identify identify VB cord-298169-2133gahl 60 12 homogeneous homogeneous JJ cord-298169-2133gahl 60 13 subgroups subgroup NNS cord-298169-2133gahl 60 14 , , , cord-298169-2133gahl 60 15 HLA HLA NNP cord-298169-2133gahl 60 16 based base VBN cord-298169-2133gahl 60 17 , , , cord-298169-2133gahl 60 18 but but CC cord-298169-2133gahl 60 19 also also RB cord-298169-2133gahl 60 20 to to TO cord-298169-2133gahl 60 21 decipher decipher VB cord-298169-2133gahl 60 22 their -PRON- PRP$ cord-298169-2133gahl 60 23 underlying underlying JJ cord-298169-2133gahl 60 24 mechanisms mechanism NNS cord-298169-2133gahl 60 25 . . . cord-298169-2133gahl 61 1 Recent recent JJ cord-298169-2133gahl 61 2 GWAS GWAS NNP cord-298169-2133gahl 61 3 and and CC cord-298169-2133gahl 61 4 haplotype haplotype NN cord-298169-2133gahl 61 5 - - HYPH cord-298169-2133gahl 61 6 based base VBN cord-298169-2133gahl 61 7 studies study NNS cord-298169-2133gahl 61 8 have have VBP cord-298169-2133gahl 61 9 revived revive VBN cord-298169-2133gahl 61 10 and and CC cord-298169-2133gahl 61 11 strengthened strengthen VBN cord-298169-2133gahl 61 12 interest interest NN cord-298169-2133gahl 61 13 in in IN cord-298169-2133gahl 61 14 the the DT cord-298169-2133gahl 61 15 roles role NNS cord-298169-2133gahl 61 16 of of IN cord-298169-2133gahl 61 17 the the DT cord-298169-2133gahl 61 18 immune immune JJ cord-298169-2133gahl 61 19 system system NN cord-298169-2133gahl 61 20 in in IN cord-298169-2133gahl 61 21 psychiatric psychiatric JJ cord-298169-2133gahl 61 22 disorders disorder NNS cord-298169-2133gahl 61 23 . . . cord-298169-2133gahl 62 1 This this DT cord-298169-2133gahl 62 2 section section NN cord-298169-2133gahl 62 3 reviews review VBZ cord-298169-2133gahl 62 4 investigations investigation NNS cord-298169-2133gahl 62 5 of of IN cord-298169-2133gahl 62 6 HLA HLA NNP cord-298169-2133gahl 62 7 gene gene NN cord-298169-2133gahl 62 8 candidate candidate NNP cord-298169-2133gahl 62 9 association association NNP cord-298169-2133gahl 62 10 in in IN cord-298169-2133gahl 62 11 schizophrenia schizophrenia NNP cord-298169-2133gahl 62 12 , , , cord-298169-2133gahl 62 13 bipolar bipolar JJ cord-298169-2133gahl 62 14 disorders disorder NNS cord-298169-2133gahl 62 15 and and CC cord-298169-2133gahl 62 16 Autism Autism NNP cord-298169-2133gahl 62 17 Spectrum Spectrum NNP cord-298169-2133gahl 62 18 Disorders Disorders NNPS cord-298169-2133gahl 62 19 , , , cord-298169-2133gahl 62 20 focusing focus VBG cord-298169-2133gahl 62 21 on on IN cord-298169-2133gahl 62 22 the the DT cord-298169-2133gahl 62 23 risk risk NN cord-298169-2133gahl 62 24 / / SYM cord-298169-2133gahl 62 25 protection protection NN cord-298169-2133gahl 62 26 that that IN cord-298169-2133gahl 62 27 HLA HLA NNP cord-298169-2133gahl 62 28 alleles allele NNS cord-298169-2133gahl 62 29 / / SYM cord-298169-2133gahl 62 30 haplotypes haplotype NNS cord-298169-2133gahl 62 31 may may MD cord-298169-2133gahl 62 32 confer confer VB cord-298169-2133gahl 62 33 on on IN cord-298169-2133gahl 62 34 specific specific JJ cord-298169-2133gahl 62 35 sub sub NN cord-298169-2133gahl 62 36 - - NNS cord-298169-2133gahl 62 37 groups group NNS cord-298169-2133gahl 62 38 . . . cord-298169-2133gahl 63 1 Accumulating accumulate VBG cord-298169-2133gahl 63 2 evidence evidence NN cord-298169-2133gahl 63 3 from from IN cord-298169-2133gahl 63 4 epidemiological epidemiological JJ cord-298169-2133gahl 63 5 , , , cord-298169-2133gahl 63 6 immunological immunological JJ cord-298169-2133gahl 63 7 , , , cord-298169-2133gahl 63 8 genetic genetic JJ cord-298169-2133gahl 63 9 , , , cord-298169-2133gahl 63 10 and and CC cord-298169-2133gahl 63 11 imaging imaging NN cord-298169-2133gahl 63 12 studies study NNS cord-298169-2133gahl 63 13 strongly strongly RB cord-298169-2133gahl 63 14 indicate indicate VBP cord-298169-2133gahl 63 15 a a DT cord-298169-2133gahl 63 16 role role NN cord-298169-2133gahl 63 17 for for IN cord-298169-2133gahl 63 18 MHC MHC NNP cord-298169-2133gahl 63 19 in in IN cord-298169-2133gahl 63 20 schizophrenia schizophrenia NN cord-298169-2133gahl 63 21 risk risk NN cord-298169-2133gahl 63 22 , , , cord-298169-2133gahl 63 23 dating date VBG cord-298169-2133gahl 63 24 from from IN cord-298169-2133gahl 63 25 the the DT cord-298169-2133gahl 63 26 1970 1970 CD cord-298169-2133gahl 63 27 's 's POS cord-298169-2133gahl 63 28 ( ( -LRB- cord-298169-2133gahl 63 29 Eberhard Eberhard NNP cord-298169-2133gahl 63 30 , , , cord-298169-2133gahl 63 31 Franzén Franzén NNP cord-298169-2133gahl 63 32 and and CC cord-298169-2133gahl 63 33 Löw Löw NNP cord-298169-2133gahl 63 34 , , , cord-298169-2133gahl 63 35 1975 1975 CD cord-298169-2133gahl 63 36 ; ; : cord-298169-2133gahl 63 37 Cazzullo Cazzullo NNP cord-298169-2133gahl 63 38 and and CC cord-298169-2133gahl 63 39 Smeraldi Smeraldi NNP cord-298169-2133gahl 63 40 , , , cord-298169-2133gahl 63 41 1979 1979 CD cord-298169-2133gahl 63 42 ) ) -RRB- cord-298169-2133gahl 63 43 . . . cord-298169-2133gahl 64 1 Previous previous JJ cord-298169-2133gahl 64 2 work work NN cord-298169-2133gahl 64 3 has have VBZ cord-298169-2133gahl 64 4 shown show VBN cord-298169-2133gahl 64 5 a a DT cord-298169-2133gahl 64 6 number number NN cord-298169-2133gahl 64 7 of of IN cord-298169-2133gahl 64 8 associations association NNS cord-298169-2133gahl 64 9 across across IN cord-298169-2133gahl 64 10 different different JJ cord-298169-2133gahl 64 11 ethnic ethnic JJ cord-298169-2133gahl 64 12 populations population NNS cord-298169-2133gahl 64 13 , , , cord-298169-2133gahl 64 14 including include VBG cord-298169-2133gahl 64 15 the the DT cord-298169-2133gahl 64 16 HLA HLA NNP cord-298169-2133gahl 64 17 - - HYPH cord-298169-2133gahl 64 18 A9 A9 NNP cord-298169-2133gahl 64 19 , , , cord-298169-2133gahl 64 20 HLA HLA NNP cord-298169-2133gahl 64 21 - - HYPH cord-298169-2133gahl 64 22 A10 A10 NNP cord-298169-2133gahl 64 23 , , , cord-298169-2133gahl 64 24 HLA HLA NNP cord-298169-2133gahl 64 25 - - HYPH cord-298169-2133gahl 64 26 DRB1 DRB1 NNP cord-298169-2133gahl 64 27 , , , cord-298169-2133gahl 64 28 and and CC cord-298169-2133gahl 64 29 HLA HLA NNP cord-298169-2133gahl 64 30 - - HYPH cord-298169-2133gahl 64 31 DQB1 DQB1 NNP cord-298169-2133gahl 64 32 alleles allele NNS cord-298169-2133gahl 64 33 . . . cord-298169-2133gahl 65 1 In in IN cord-298169-2133gahl 65 2 2009 2009 CD cord-298169-2133gahl 65 3 , , , cord-298169-2133gahl 65 4 three three CD cord-298169-2133gahl 65 5 GWAS GWAS NNP cord-298169-2133gahl 65 6 and and CC cord-298169-2133gahl 65 7 a a DT cord-298169-2133gahl 65 8 meta meta JJ cord-298169-2133gahl 65 9 - - HYPH cord-298169-2133gahl 65 10 analysis analysis NN cord-298169-2133gahl 65 11 of of IN cord-298169-2133gahl 65 12 these these DT cord-298169-2133gahl 65 13 GWAS GWAS NNP cord-298169-2133gahl 65 14 were be VBD cord-298169-2133gahl 65 15 published publish VBN cord-298169-2133gahl 65 16 in in IN cord-298169-2133gahl 65 17 Nature Nature NNP cord-298169-2133gahl 65 18 , , , cord-298169-2133gahl 65 19 revealing reveal VBG cord-298169-2133gahl 65 20 a a DT cord-298169-2133gahl 65 21 strong strong JJ cord-298169-2133gahl 65 22 association association NN cord-298169-2133gahl 65 23 between between IN cord-298169-2133gahl 65 24 the the DT cord-298169-2133gahl 65 25 MHC MHC NNP cord-298169-2133gahl 65 26 region region NN cord-298169-2133gahl 65 27 and and CC cord-298169-2133gahl 65 28 schizophrenia schizophrenia NN cord-298169-2133gahl 65 29 , , , cord-298169-2133gahl 65 30 although although IN cord-298169-2133gahl 65 31 without without IN cord-298169-2133gahl 65 32 any any DT cord-298169-2133gahl 65 33 precision precision NN cord-298169-2133gahl 65 34 as as IN cord-298169-2133gahl 65 35 to to IN cord-298169-2133gahl 65 36 the the DT cord-298169-2133gahl 65 37 specific specific JJ cord-298169-2133gahl 65 38 location location NN cord-298169-2133gahl 65 39 ( ( -LRB- cord-298169-2133gahl 65 40 Purcell Purcell NNP cord-298169-2133gahl 65 41 et et NNP cord-298169-2133gahl 65 42 al al NNP cord-298169-2133gahl 65 43 , , , cord-298169-2133gahl 65 44 2009 2009 CD cord-298169-2133gahl 65 45 , , , cord-298169-2133gahl 65 46 Shi Shi NNP cord-298169-2133gahl 65 47 et et NNP cord-298169-2133gahl 65 48 al al NNP cord-298169-2133gahl 65 49 , , , cord-298169-2133gahl 65 50 2009 2009 CD cord-298169-2133gahl 65 51 Stefansson Stefansson NNP cord-298169-2133gahl 65 52 et et NNP cord-298169-2133gahl 65 53 al al NNP cord-298169-2133gahl 65 54 , , , cord-298169-2133gahl 65 55 2009 2009 CD cord-298169-2133gahl 65 56 ) ) -RRB- cord-298169-2133gahl 65 57 . . . cord-298169-2133gahl 66 1 Subsequent subsequent JJ cord-298169-2133gahl 66 2 studies study NNS cord-298169-2133gahl 66 3 using use VBG cord-298169-2133gahl 66 4 GWAS GWAS NNP cord-298169-2133gahl 66 5 subjected subject VBN cord-298169-2133gahl 66 6 to to IN cord-298169-2133gahl 66 7 HLA HLA NNP cord-298169-2133gahl 66 8 imputation imputation NN cord-298169-2133gahl 66 9 of of IN cord-298169-2133gahl 66 10 classical classical JJ cord-298169-2133gahl 66 11 HLA HLA NNP cord-298169-2133gahl 66 12 alleles allele NNS cord-298169-2133gahl 66 13 , , , cord-298169-2133gahl 66 14 revealed reveal VBD cord-298169-2133gahl 66 15 a a DT cord-298169-2133gahl 66 16 marked marked JJ cord-298169-2133gahl 66 17 dominant dominant JJ cord-298169-2133gahl 66 18 protective protective JJ cord-298169-2133gahl 66 19 effect effect NN cord-298169-2133gahl 66 20 conferred confer VBN cord-298169-2133gahl 66 21 by by IN cord-298169-2133gahl 66 22 HLA HLA NNP cord-298169-2133gahl 66 23 - - HYPH cord-298169-2133gahl 66 24 A*01 A*01 NNP cord-298169-2133gahl 66 25 , , , cord-298169-2133gahl 66 26 B*08 B*08 NNP cord-298169-2133gahl 66 27 and and CC cord-298169-2133gahl 66 28 DRB1 DRB1 NNP cord-298169-2133gahl 67 1 * * NFP cord-298169-2133gahl 67 2 03 03 CD cord-298169-2133gahl 68 1 ( ( -LRB- cord-298169-2133gahl 68 2 Donnelly Donnelly NNP cord-298169-2133gahl 68 3 et et NNP cord-298169-2133gahl 68 4 al al NNP cord-298169-2133gahl 68 5 , , , cord-298169-2133gahl 68 6 2012 2012 CD cord-298169-2133gahl 68 7 ) ) -RRB- cord-298169-2133gahl 68 8 . . . cord-298169-2133gahl 69 1 These these DT cord-298169-2133gahl 69 2 alleles allele NNS cord-298169-2133gahl 69 3 are be VBP cord-298169-2133gahl 69 4 all all DT cord-298169-2133gahl 69 5 derived derive VBN cord-298169-2133gahl 69 6 from from IN cord-298169-2133gahl 69 7 the the DT cord-298169-2133gahl 69 8 so so RB cord-298169-2133gahl 69 9 - - HYPH cord-298169-2133gahl 69 10 called call VBN cord-298169-2133gahl 69 11 8.1 8.1 CD cord-298169-2133gahl 69 12 " " `` cord-298169-2133gahl 69 13 autoimmune autoimmune JJ cord-298169-2133gahl 69 14 " " '' cord-298169-2133gahl 69 15 ancestral ancestral JJ cord-298169-2133gahl 69 16 haplotype haplotype NN cord-298169-2133gahl 69 17 ( ( -LRB- cord-298169-2133gahl 69 18 8.1AH 8.1ah CD cord-298169-2133gahl 69 19 ) ) -RRB- cord-298169-2133gahl 69 20 ( ( -LRB- cord-298169-2133gahl 70 1 A*01~B*08~Cw*07~DRB1 A*01~B*08~Cw*07~DRB1 NNP cord-298169-2133gahl 71 1 * * NFP cord-298169-2133gahl 71 2 03~DQB1 03~dqb1 CD cord-298169-2133gahl 72 1 * * NFP cord-298169-2133gahl 72 2 02 02 CD cord-298169-2133gahl 72 3 ) ) -RRB- cord-298169-2133gahl 72 4 . . . cord-298169-2133gahl 73 1 The the DT cord-298169-2133gahl 73 2 8.1 8.1 CD cord-298169-2133gahl 73 3 AH ah NN cord-298169-2133gahl 73 4 is be VBZ cord-298169-2133gahl 73 5 the the DT cord-298169-2133gahl 73 6 most most RBS cord-298169-2133gahl 73 7 associated associate VBN cord-298169-2133gahl 73 8 HLA HLA NNP cord-298169-2133gahl 73 9 haplotype haplotype NN cord-298169-2133gahl 73 10 with with IN cord-298169-2133gahl 73 11 inflammatory inflammatory JJ cord-298169-2133gahl 73 12 processes process NNS cord-298169-2133gahl 73 13 and and CC cord-298169-2133gahl 73 14 autoimmune autoimmune JJ cord-298169-2133gahl 73 15 diseases disease NNS cord-298169-2133gahl 73 16 , , , cord-298169-2133gahl 73 17 including include VBG cord-298169-2133gahl 73 18 type1 type1 JJ cord-298169-2133gahl 73 19 diabetes diabete NNS cord-298169-2133gahl 73 20 , , , cord-298169-2133gahl 73 21 celiac celiac JJ cord-298169-2133gahl 73 22 disease disease NN cord-298169-2133gahl 73 23 , , , cord-298169-2133gahl 73 24 Grave Grave NNP cord-298169-2133gahl 73 25 's 's POS cord-298169-2133gahl 73 26 disease disease NN cord-298169-2133gahl 73 27 , , , cord-298169-2133gahl 73 28 and and CC cord-298169-2133gahl 73 29 myasthenia myasthenia NN cord-298169-2133gahl 73 30 gravis gravis NN cord-298169-2133gahl 73 31 ( ( -LRB- cord-298169-2133gahl 73 32 Price price NN cord-298169-2133gahl 73 33 et et NNP cord-298169-2133gahl 73 34 al al NNP cord-298169-2133gahl 73 35 , , , cord-298169-2133gahl 73 36 1999 1999 CD cord-298169-2133gahl 73 37 ) ) -RRB- cord-298169-2133gahl 73 38 , , , cord-298169-2133gahl 73 39 a a DT cord-298169-2133gahl 73 40 situation situation NN cord-298169-2133gahl 73 41 that that WDT cord-298169-2133gahl 73 42 may may MD cord-298169-2133gahl 73 43 appear appear VB cord-298169-2133gahl 73 44 at at IN cord-298169-2133gahl 73 45 first first JJ cord-298169-2133gahl 73 46 sight sight NN cord-298169-2133gahl 73 47 contra contra JJ cord-298169-2133gahl 73 48 - - HYPH cord-298169-2133gahl 73 49 intuitive intuitive JJ cord-298169-2133gahl 73 50 according accord VBG cord-298169-2133gahl 73 51 to to IN cord-298169-2133gahl 73 52 the the DT cord-298169-2133gahl 73 53 protecting protect VBG cord-298169-2133gahl 73 54 effect effect NN cord-298169-2133gahl 73 55 conferred confer VBN cord-298169-2133gahl 73 56 against against IN cord-298169-2133gahl 73 57 schizophrenia schizophrenia NNP cord-298169-2133gahl 73 58 risk risk NN cord-298169-2133gahl 73 59 . . . cord-298169-2133gahl 74 1 A a DT cord-298169-2133gahl 74 2 deeper deep JJR cord-298169-2133gahl 74 3 exploration exploration NN cord-298169-2133gahl 74 4 of of IN cord-298169-2133gahl 74 5 the the DT cord-298169-2133gahl 74 6 HLA HLA NNP cord-298169-2133gahl 74 7 region region NN cord-298169-2133gahl 74 8 further further RB cord-298169-2133gahl 74 9 revealed reveal VBD cord-298169-2133gahl 74 10 a a DT cord-298169-2133gahl 74 11 major major JJ cord-298169-2133gahl 74 12 contribution contribution NN cord-298169-2133gahl 74 13 to to IN cord-298169-2133gahl 74 14 schizophrenia schizophrenia NN cord-298169-2133gahl 74 15 risk risk NN cord-298169-2133gahl 74 16 mediated mediate VBN cord-298169-2133gahl 74 17 by by IN cord-298169-2133gahl 74 18 increased increase VBN cord-298169-2133gahl 74 19 complement complement NNP cord-298169-2133gahl 74 20 C4A c4a CD cord-298169-2133gahl 74 21 gene gene NN cord-298169-2133gahl 74 22 copy copy NN cord-298169-2133gahl 74 23 number number NN cord-298169-2133gahl 74 24 with with IN cord-298169-2133gahl 74 25 consequent consequent JJ cord-298169-2133gahl 74 26 C4-dependant C4-dependant NFP cord-298169-2133gahl 74 27 neuro neuro JJ cord-298169-2133gahl 74 28 - - HYPH cord-298169-2133gahl 74 29 synaptic synaptic JJ cord-298169-2133gahl 74 30 pruning pruning NN cord-298169-2133gahl 74 31 ( ( -LRB- cord-298169-2133gahl 74 32 Sekar Sekar NNP cord-298169-2133gahl 74 33 et et NNP cord-298169-2133gahl 74 34 al al NNP cord-298169-2133gahl 74 35 , , , cord-298169-2133gahl 74 36 2016 2016 CD cord-298169-2133gahl 74 37 ) ) -RRB- cord-298169-2133gahl 74 38 . . . cord-298169-2133gahl 75 1 The the DT cord-298169-2133gahl 75 2 complement complement NN cord-298169-2133gahl 75 3 system system NN cord-298169-2133gahl 75 4 is be VBZ cord-298169-2133gahl 75 5 not not RB cord-298169-2133gahl 75 6 only only RB cord-298169-2133gahl 75 7 in in IN cord-298169-2133gahl 75 8 first first JJ cord-298169-2133gahl 75 9 - - HYPH cord-298169-2133gahl 75 10 line line NN cord-298169-2133gahl 75 11 defense defense NN cord-298169-2133gahl 75 12 against against IN cord-298169-2133gahl 75 13 pathogens pathogen NNS cord-298169-2133gahl 75 14 but but CC cord-298169-2133gahl 75 15 also also RB cord-298169-2133gahl 75 16 a a DT cord-298169-2133gahl 75 17 major major JJ cord-298169-2133gahl 75 18 contributor contributor NN cord-298169-2133gahl 75 19 to to IN cord-298169-2133gahl 75 20 synaptic synaptic JJ cord-298169-2133gahl 75 21 pruning pruning NN cord-298169-2133gahl 75 22 during during IN cord-298169-2133gahl 75 23 neurodevelopment neurodevelopment JJ cord-298169-2133gahl 75 24 ( ( -LRB- cord-298169-2133gahl 75 25 Druart Druart NNP cord-298169-2133gahl 75 26 and and CC cord-298169-2133gahl 75 27 Le Le NNP cord-298169-2133gahl 75 28 Magueresse Magueresse NNP cord-298169-2133gahl 75 29 , , , cord-298169-2133gahl 75 30 2019 2019 CD cord-298169-2133gahl 75 31 ) ) -RRB- cord-298169-2133gahl 75 32 . . . cord-298169-2133gahl 76 1 However however RB cord-298169-2133gahl 76 2 , , , cord-298169-2133gahl 76 3 it -PRON- PRP cord-298169-2133gahl 76 4 is be VBZ cord-298169-2133gahl 76 5 important important JJ cord-298169-2133gahl 76 6 to to TO cord-298169-2133gahl 76 7 signal signal VB cord-298169-2133gahl 76 8 that that IN cord-298169-2133gahl 76 9 the the DT cord-298169-2133gahl 76 10 Sekar Sekar NNP cord-298169-2133gahl 76 11 's 's POS cord-298169-2133gahl 76 12 study study NN cord-298169-2133gahl 76 13 not not RB cord-298169-2133gahl 76 14 only only RB cord-298169-2133gahl 76 15 suffer suffer VB cord-298169-2133gahl 76 16 from from IN cord-298169-2133gahl 76 17 absence absence NN cord-298169-2133gahl 76 18 of of IN cord-298169-2133gahl 76 19 replication replication NN cord-298169-2133gahl 76 20 especially especially RB cord-298169-2133gahl 76 21 in in IN cord-298169-2133gahl 76 22 ethically ethically RB cord-298169-2133gahl 76 23 - - HYPH cord-298169-2133gahl 76 24 distant distant JJ cord-298169-2133gahl 76 25 population population NN cord-298169-2133gahl 76 26 groups group NNS cord-298169-2133gahl 76 27 such such JJ cord-298169-2133gahl 76 28 as as IN cord-298169-2133gahl 76 29 Asians Asians NNPS cord-298169-2133gahl 76 30 ( ( -LRB- cord-298169-2133gahl 76 31 Lam Lam NNP cord-298169-2133gahl 76 32 et et FW cord-298169-2133gahl 76 33 al al NNP cord-298169-2133gahl 76 34 , , , cord-298169-2133gahl 76 35 2019 2019 CD cord-298169-2133gahl 76 36 ) ) -RRB- cord-298169-2133gahl 76 37 but but CC cord-298169-2133gahl 76 38 also also RB cord-298169-2133gahl 76 39 from from IN cord-298169-2133gahl 76 40 the the DT cord-298169-2133gahl 76 41 complexity complexity NN cord-298169-2133gahl 76 42 of of IN cord-298169-2133gahl 76 43 long long JJ cord-298169-2133gahl 76 44 - - HYPH cord-298169-2133gahl 76 45 range range NN cord-298169-2133gahl 76 46 imputation imputation NN cord-298169-2133gahl 76 47 statistics statistic NNS cord-298169-2133gahl 76 48 and and CC cord-298169-2133gahl 76 49 absence absence NN cord-298169-2133gahl 76 50 of of IN cord-298169-2133gahl 76 51 direct direct JJ cord-298169-2133gahl 76 52 inference inference NN cord-298169-2133gahl 76 53 of of IN cord-298169-2133gahl 76 54 C4 C4 NNP cord-298169-2133gahl 76 55 haplotypes haplotype NNS cord-298169-2133gahl 76 56 along along IN cord-298169-2133gahl 76 57 their -PRON- PRP$ cord-298169-2133gahl 76 58 respective respective JJ cord-298169-2133gahl 76 59 expression expression NN cord-298169-2133gahl 76 60 status status NN cord-298169-2133gahl 76 61 . . . cord-298169-2133gahl 77 1 It -PRON- PRP cord-298169-2133gahl 77 2 is be VBZ cord-298169-2133gahl 77 3 evident evident JJ cord-298169-2133gahl 77 4 that that IN cord-298169-2133gahl 77 5 the the DT cord-298169-2133gahl 77 6 full full JJ cord-298169-2133gahl 77 7 sequencing sequencing NN cord-298169-2133gahl 77 8 of of IN cord-298169-2133gahl 77 9 the the DT cord-298169-2133gahl 77 10 C4 c4 NN cord-298169-2133gahl 77 11 cluster cluster NN cord-298169-2133gahl 77 12 may may MD cord-298169-2133gahl 77 13 help help VB cord-298169-2133gahl 77 14 genetic genetic JJ cord-298169-2133gahl 77 15 dissection dissection NN cord-298169-2133gahl 77 16 of of IN cord-298169-2133gahl 77 17 this this DT cord-298169-2133gahl 77 18 complex complex JJ cord-298169-2133gahl 77 19 region region NN cord-298169-2133gahl 77 20 . . . cord-298169-2133gahl 78 1 Besides besides IN cord-298169-2133gahl 78 2 these these DT cord-298169-2133gahl 78 3 considerations consideration NNS cord-298169-2133gahl 78 4 , , , cord-298169-2133gahl 78 5 recent recent JJ cord-298169-2133gahl 78 6 investigations investigation NNS cord-298169-2133gahl 78 7 have have VBP cord-298169-2133gahl 78 8 established establish VBN cord-298169-2133gahl 78 9 a a DT cord-298169-2133gahl 78 10 link link NN cord-298169-2133gahl 78 11 between between IN cord-298169-2133gahl 78 12 the the DT cord-298169-2133gahl 78 13 C4 C4 NNP cord-298169-2133gahl 78 14 locus locus NN cord-298169-2133gahl 78 15 and and CC cord-298169-2133gahl 78 16 classical classical JJ cord-298169-2133gahl 78 17 HLA HLA NNP cord-298169-2133gahl 78 18 haplotype haplotype NN cord-298169-2133gahl 78 19 diversity diversity NN cord-298169-2133gahl 78 20 in in IN cord-298169-2133gahl 78 21 the the DT cord-298169-2133gahl 78 22 modulation modulation NN cord-298169-2133gahl 78 23 of of IN cord-298169-2133gahl 78 24 schizophrenia schizophrenia NN cord-298169-2133gahl 78 25 risk risk NN cord-298169-2133gahl 78 26 . . . cord-298169-2133gahl 79 1 Indeed indeed RB cord-298169-2133gahl 79 2 , , , cord-298169-2133gahl 79 3 the the DT cord-298169-2133gahl 79 4 protective protective JJ cord-298169-2133gahl 79 5 status status NN cord-298169-2133gahl 79 6 conferred confer VBN cord-298169-2133gahl 79 7 by by IN cord-298169-2133gahl 79 8 the the DT cord-298169-2133gahl 79 9 8.1AH 8.1ah CD cord-298169-2133gahl 79 10 haplotype haplotype NN cord-298169-2133gahl 79 11 plausibly plausibly RB cord-298169-2133gahl 79 12 arises arise VBZ cord-298169-2133gahl 79 13 from from IN cord-298169-2133gahl 79 14 this this DT cord-298169-2133gahl 79 15 haplotype haplotype NN cord-298169-2133gahl 79 16 naturally naturally RB cord-298169-2133gahl 79 17 lacks lack VBZ cord-298169-2133gahl 79 18 the the DT cord-298169-2133gahl 79 19 C4 C4 NNP cord-298169-2133gahl 79 20 locus locus NN cord-298169-2133gahl 79 21 . . . cord-298169-2133gahl 80 1 We -PRON- PRP cord-298169-2133gahl 80 2 recently recently RB cord-298169-2133gahl 80 3 showed show VBD cord-298169-2133gahl 80 4 that that IN cord-298169-2133gahl 80 5 a a DT cord-298169-2133gahl 80 6 8.1 8.1 CD cord-298169-2133gahl 80 7 AH ah NN cord-298169-2133gahl 80 8 - - HYPH cord-298169-2133gahl 80 9 derived derive VBN cord-298169-2133gahl 80 10 HLA HLA NNP cord-298169-2133gahl 80 11 haplotype haplotype NN cord-298169-2133gahl 80 12 was be VBD cord-298169-2133gahl 80 13 significantly significantly RB cord-298169-2133gahl 80 14 less less RBR cord-298169-2133gahl 80 15 frequent frequent JJ cord-298169-2133gahl 80 16 in in IN cord-298169-2133gahl 80 17 schizophrenia schizophrenia NN cord-298169-2133gahl 80 18 patients patient NNS cord-298169-2133gahl 80 19 with with IN cord-298169-2133gahl 80 20 early early JJ cord-298169-2133gahl 80 21 onset onset NN cord-298169-2133gahl 80 22 , , , cord-298169-2133gahl 80 23 whilst whilst IN cord-298169-2133gahl 80 24 gradually gradually RB cord-298169-2133gahl 80 25 increasing increase VBG cord-298169-2133gahl 80 26 in in IN cord-298169-2133gahl 80 27 frequency frequency NN cord-298169-2133gahl 80 28 with with IN cord-298169-2133gahl 80 29 the the DT cord-298169-2133gahl 80 30 age age NN cord-298169-2133gahl 80 31 of of IN cord-298169-2133gahl 80 32 schizophrenia schizophrenia NN cord-298169-2133gahl 80 33 onset onset NN cord-298169-2133gahl 80 34 . . . cord-298169-2133gahl 81 1 This this DT cord-298169-2133gahl 81 2 would would MD cord-298169-2133gahl 81 3 suggest suggest VB cord-298169-2133gahl 81 4 that that IN cord-298169-2133gahl 81 5 8.1 8.1 CD cord-298169-2133gahl 81 6 AH ah UH cord-298169-2133gahl 81 7 , , , cord-298169-2133gahl 81 8 via via IN cord-298169-2133gahl 81 9 decreased decrease VBN cord-298169-2133gahl 81 10 C4 c4 NN cord-298169-2133gahl 81 11 expression expression NN cord-298169-2133gahl 81 12 , , , cord-298169-2133gahl 81 13 leads lead VBZ cord-298169-2133gahl 81 14 to to IN cord-298169-2133gahl 81 15 less less JJR cord-298169-2133gahl 81 16 synaptic synaptic JJ cord-298169-2133gahl 81 17 pruning pruning NN cord-298169-2133gahl 81 18 and and CC cord-298169-2133gahl 81 19 cortical cortical JJ cord-298169-2133gahl 81 20 thinning thinning NN cord-298169-2133gahl 81 21 , , , cord-298169-2133gahl 81 22 thereby thereby RB cord-298169-2133gahl 81 23 delaying delay VBG cord-298169-2133gahl 81 24 the the DT cord-298169-2133gahl 81 25 age age NN cord-298169-2133gahl 81 26 of of IN cord-298169-2133gahl 81 27 schizophrenia schizophrenia NN cord-298169-2133gahl 81 28 onset onset NN cord-298169-2133gahl 81 29 , , , cord-298169-2133gahl 81 30 whilst whilst IN cord-298169-2133gahl 81 31 concurrently concurrently RB cord-298169-2133gahl 81 32 potentially potentially RB cord-298169-2133gahl 81 33 favoring favor VBG cord-298169-2133gahl 81 34 heightened heighten VBN cord-298169-2133gahl 81 35 autoimmune autoimmune JJ cord-298169-2133gahl 81 36 processes process NNS cord-298169-2133gahl 81 37 due due JJ cord-298169-2133gahl 81 38 to to IN cord-298169-2133gahl 81 39 its -PRON- PRP$ cord-298169-2133gahl 81 40 proinflammatory proinflammatory JJ cord-298169-2133gahl 81 41 properties property NNS cord-298169-2133gahl 81 42 . . . cord-298169-2133gahl 82 1 In in IN cord-298169-2133gahl 82 2 contrast contrast NN cord-298169-2133gahl 82 3 , , , cord-298169-2133gahl 82 4 we -PRON- PRP cord-298169-2133gahl 82 5 hypothesized hypothesize VBD cord-298169-2133gahl 82 6 that that IN cord-298169-2133gahl 82 7 schizophrenia schizophrenia NN cord-298169-2133gahl 82 8 patients patient NNS cord-298169-2133gahl 82 9 not not RB cord-298169-2133gahl 82 10 bearing bear VBG cord-298169-2133gahl 82 11 8.1 8.1 CD cord-298169-2133gahl 82 12 AH ah NN cord-298169-2133gahl 82 13 - - HYPH cord-298169-2133gahl 82 14 derived derive VBN cord-298169-2133gahl 82 15 HLA HLA NNP cord-298169-2133gahl 82 16 haplotypes haplotype NNS cord-298169-2133gahl 82 17 have have VBP cord-298169-2133gahl 82 18 an an DT cord-298169-2133gahl 82 19 active active JJ cord-298169-2133gahl 82 20 C4 c4 NN cord-298169-2133gahl 82 21 complement complement NN cord-298169-2133gahl 82 22 and and CC cord-298169-2133gahl 82 23 may may MD cord-298169-2133gahl 82 24 suffer suffer VB cord-298169-2133gahl 82 25 from from IN cord-298169-2133gahl 82 26 a a DT cord-298169-2133gahl 82 27 more more RBR cord-298169-2133gahl 82 28 severe severe JJ cord-298169-2133gahl 82 29 form form NN cord-298169-2133gahl 82 30 of of IN cord-298169-2133gahl 82 31 the the DT cord-298169-2133gahl 82 32 disorder disorder NN cord-298169-2133gahl 82 33 , , , cord-298169-2133gahl 82 34 characterized characterize VBN cord-298169-2133gahl 82 35 by by IN cord-298169-2133gahl 82 36 early early JJ cord-298169-2133gahl 82 37 age age NN cord-298169-2133gahl 82 38 at at IN cord-298169-2133gahl 82 39 onset onset NN cord-298169-2133gahl 82 40 , , , cord-298169-2133gahl 82 41 increased increase VBN cord-298169-2133gahl 82 42 synaptic synaptic JJ cord-298169-2133gahl 82 43 pruning pruning NN cord-298169-2133gahl 82 44 and and CC cord-298169-2133gahl 82 45 cortical cortical JJ cord-298169-2133gahl 82 46 thinning thinning NN cord-298169-2133gahl 82 47 , , , cord-298169-2133gahl 82 48 whilst whilst IN cord-298169-2133gahl 82 49 being be VBG cord-298169-2133gahl 82 50 less less RBR cord-298169-2133gahl 82 51 prone prone JJ cord-298169-2133gahl 82 52 to to TO cord-298169-2133gahl 82 53 develop develop VB cord-298169-2133gahl 82 54 autoimmune autoimmune JJ cord-298169-2133gahl 82 55 disorders disorder NNS cord-298169-2133gahl 82 56 . . . cord-298169-2133gahl 83 1 This this DT cord-298169-2133gahl 83 2 is be VBZ cord-298169-2133gahl 83 3 in in IN cord-298169-2133gahl 83 4 line line NN cord-298169-2133gahl 83 5 with with IN cord-298169-2133gahl 83 6 previous previous JJ cord-298169-2133gahl 83 7 observations observation NNS cord-298169-2133gahl 83 8 that that IN cord-298169-2133gahl 83 9 carriers carrier NNS cord-298169-2133gahl 83 10 of of IN cord-298169-2133gahl 83 11 MHC MHC NNP cord-298169-2133gahl 83 12 - - HYPH cord-298169-2133gahl 83 13 linked link VBN cord-298169-2133gahl 83 14 risk risk NN cord-298169-2133gahl 83 15 variants variant NNS cord-298169-2133gahl 83 16 ( ( -LRB- cord-298169-2133gahl 83 17 rs2596532 rs2596532 NNP cord-298169-2133gahl 83 18 ) ) -RRB- cord-298169-2133gahl 83 19 have have VB cord-298169-2133gahl 83 20 larger large JJR cord-298169-2133gahl 83 21 ventricles ventricle NNS cord-298169-2133gahl 84 1 ( ( -LRB- cord-298169-2133gahl 84 2 Agartz Agartz NNP cord-298169-2133gahl 84 3 et et NNP cord-298169-2133gahl 84 4 al al NNP cord-298169-2133gahl 84 5 , , , cord-298169-2133gahl 84 6 2011 2011 CD cord-298169-2133gahl 84 7 ) ) -RRB- cord-298169-2133gahl 84 8 . . . cord-298169-2133gahl 85 1 Even even RB cord-298169-2133gahl 85 2 if if IN cord-298169-2133gahl 85 3 it -PRON- PRP cord-298169-2133gahl 85 4 is be VBZ cord-298169-2133gahl 85 5 assumed assume VBN cord-298169-2133gahl 85 6 that that IN cord-298169-2133gahl 85 7 the the DT cord-298169-2133gahl 85 8 above above RB cord-298169-2133gahl 85 9 - - HYPH cord-298169-2133gahl 85 10 mentioned mention VBN cord-298169-2133gahl 85 11 mechanisms mechanism NNS cord-298169-2133gahl 85 12 , , , cord-298169-2133gahl 85 13 if if IN cord-298169-2133gahl 85 14 proven prove VBN cord-298169-2133gahl 85 15 , , , cord-298169-2133gahl 85 16 would would MD cord-298169-2133gahl 85 17 be be VB cord-298169-2133gahl 85 18 not not RB cord-298169-2133gahl 85 19 the the DT cord-298169-2133gahl 85 20 unique unique JJ cord-298169-2133gahl 85 21 disease disease NN cord-298169-2133gahl 85 22 process process NN cord-298169-2133gahl 85 23 , , , cord-298169-2133gahl 85 24 overall overall JJ cord-298169-2133gahl 85 25 HLA HLA NNP cord-298169-2133gahl 85 26 data datum NNS cord-298169-2133gahl 85 27 may may MD cord-298169-2133gahl 85 28 highlight highlight VB cord-298169-2133gahl 85 29 the the DT cord-298169-2133gahl 85 30 possibility possibility NN cord-298169-2133gahl 85 31 that that IN cord-298169-2133gahl 85 32 HLA HLA NNP cord-298169-2133gahl 85 33 genetics genetic NNS cord-298169-2133gahl 85 34 will will MD cord-298169-2133gahl 85 35 help help VB cord-298169-2133gahl 85 36 to to TO cord-298169-2133gahl 85 37 identify identify VB cord-298169-2133gahl 85 38 homogeneous homogeneous JJ cord-298169-2133gahl 85 39 sub sub NN cord-298169-2133gahl 85 40 - - NNS cord-298169-2133gahl 85 41 groups group NNS cord-298169-2133gahl 85 42 of of IN cord-298169-2133gahl 85 43 schizophrenia schizophrenia NN cord-298169-2133gahl 85 44 patients patient NNS cord-298169-2133gahl 85 45 . . . cord-298169-2133gahl 86 1 Although although IN cord-298169-2133gahl 86 2 GWAS GWAS NNP cord-298169-2133gahl 86 3 clearly clearly RB cord-298169-2133gahl 86 4 indicate indicate VBP cord-298169-2133gahl 86 5 that that IN cord-298169-2133gahl 86 6 the the DT cord-298169-2133gahl 86 7 MHC MHC NNP cord-298169-2133gahl 86 8 region region NN cord-298169-2133gahl 86 9 confer confer VBP cord-298169-2133gahl 86 10 an an DT cord-298169-2133gahl 86 11 increased increase VBN cord-298169-2133gahl 86 12 Autism Autism NNP cord-298169-2133gahl 86 13 Spectrum Spectrum NNP cord-298169-2133gahl 86 14 Overall Overall NNP cord-298169-2133gahl 86 15 , , , cord-298169-2133gahl 86 16 these these DT cord-298169-2133gahl 86 17 data datum NNS cord-298169-2133gahl 86 18 give give VBP cord-298169-2133gahl 86 19 some some DT cord-298169-2133gahl 86 20 indication indication NN cord-298169-2133gahl 86 21 of of IN cord-298169-2133gahl 86 22 the the DT cord-298169-2133gahl 86 23 role role NN cord-298169-2133gahl 86 24 that that WDT cord-298169-2133gahl 86 25 HLA HLA NNP cord-298169-2133gahl 86 26 haplotypes haplotype NNS cord-298169-2133gahl 86 27 may may MD cord-298169-2133gahl 86 28 play play VB cord-298169-2133gahl 86 29 in in IN cord-298169-2133gahl 86 30 the the DT cord-298169-2133gahl 86 31 abnormal abnormal JJ cord-298169-2133gahl 86 32 neurodevelopment neurodevelopment NN cord-298169-2133gahl 86 33 as as RB cord-298169-2133gahl 86 34 well well RB cord-298169-2133gahl 86 35 as as IN cord-298169-2133gahl 86 36 in in IN cord-298169-2133gahl 86 37 the the DT cord-298169-2133gahl 86 38 systemic systemic JJ cord-298169-2133gahl 86 39 and and CC cord-298169-2133gahl 86 40 gastro gastro JJ cord-298169-2133gahl 86 41 - - JJ cord-298169-2133gahl 86 42 intestinal intestinal JJ cord-298169-2133gahl 86 43 inflammatory inflammatory JJ cord-298169-2133gahl 86 44 processes process NNS cord-298169-2133gahl 86 45 at at IN cord-298169-2133gahl 86 46 work work NN cord-298169-2133gahl 86 47 in in IN cord-298169-2133gahl 86 48 Autism Autism NNP cord-298169-2133gahl 86 49 . . . cord-298169-2133gahl 87 1 We -PRON- PRP cord-298169-2133gahl 87 2 recently recently RB cord-298169-2133gahl 87 3 reported report VBD cord-298169-2133gahl 87 4 an an DT cord-298169-2133gahl 87 5 association association NN cord-298169-2133gahl 87 6 between between IN cord-298169-2133gahl 87 7 an an DT cord-298169-2133gahl 87 8 8.1 8.1 CD cord-298169-2133gahl 87 9 AH AH NNP cord-298169-2133gahl 87 10 derived derive VBD cord-298169-2133gahl 87 11 HLA HLA NNP cord-298169-2133gahl 87 12 haplotype haplotype NN cord-298169-2133gahl 87 13 and and CC cord-298169-2133gahl 87 14 bipolar bipolar JJ cord-298169-2133gahl 87 15 disorder disorder NN cord-298169-2133gahl 87 16 , , , cord-298169-2133gahl 87 17 specifically specifically RB cord-298169-2133gahl 87 18 in in IN cord-298169-2133gahl 87 19 patients patient NNS cord-298169-2133gahl 87 20 with with IN cord-298169-2133gahl 87 21 severe severe JJ cord-298169-2133gahl 87 22 forms form NNS cord-298169-2133gahl 87 23 of of IN cord-298169-2133gahl 87 24 the the DT cord-298169-2133gahl 87 25 disorder disorder NN cord-298169-2133gahl 87 26 defined define VBN cord-298169-2133gahl 87 27 by by IN cord-298169-2133gahl 87 28 rapid rapid JJ cord-298169-2133gahl 87 29 cycling cycling NN cord-298169-2133gahl 87 30 and/or and/or CC cord-298169-2133gahl 87 31 personal personal JJ cord-298169-2133gahl 87 32 history history NN cord-298169-2133gahl 87 33 of of IN cord-298169-2133gahl 87 34 suicidal suicidal JJ cord-298169-2133gahl 87 35 behaviors behavior NNS cord-298169-2133gahl 87 36 . . . cord-298169-2133gahl 88 1 This this DT cord-298169-2133gahl 88 2 association association NN cord-298169-2133gahl 88 3 might may MD cord-298169-2133gahl 88 4 also also RB cord-298169-2133gahl 88 5 underline underline VB cord-298169-2133gahl 88 6 the the DT cord-298169-2133gahl 88 7 well well RB cord-298169-2133gahl 88 8 - - HYPH cord-298169-2133gahl 88 9 known know VBN cord-298169-2133gahl 88 10 high high JJ cord-298169-2133gahl 88 11 frequency frequency NN cord-298169-2133gahl 88 12 of of IN cord-298169-2133gahl 88 13 auto auto NN cord-298169-2133gahl 88 14 - - HYPH cord-298169-2133gahl 88 15 immune immune JJ cord-298169-2133gahl 88 16 disorders disorder NNS cord-298169-2133gahl 88 17 in in IN cord-298169-2133gahl 88 18 bipolar bipolar JJ cord-298169-2133gahl 88 19 patients patient NNS cord-298169-2133gahl 88 20 , , , cord-298169-2133gahl 88 21 including include VBG cord-298169-2133gahl 88 22 elevated elevated JJ cord-298169-2133gahl 88 23 levels level NNS cord-298169-2133gahl 88 24 of of IN cord-298169-2133gahl 88 25 anti anti JJ cord-298169-2133gahl 88 26 - - JJ cord-298169-2133gahl 88 27 thyroid thyroid JJ cord-298169-2133gahl 88 28 or or CC cord-298169-2133gahl 88 29 other other JJ cord-298169-2133gahl 88 30 organ organ NN cord-298169-2133gahl 88 31 - - HYPH cord-298169-2133gahl 88 32 specific specific JJ cord-298169-2133gahl 88 33 autoantibodies autoantibody NNS cord-298169-2133gahl 88 34 ( ( -LRB- cord-298169-2133gahl 88 35 Padmos Padmos NNP cord-298169-2133gahl 88 36 et et NNP cord-298169-2133gahl 88 37 al al NNP cord-298169-2133gahl 88 38 , , , cord-298169-2133gahl 88 39 2004 2004 CD cord-298169-2133gahl 88 40 ; ; : cord-298169-2133gahl 88 41 Jeppesen Jeppesen NNP cord-298169-2133gahl 88 42 et et NNP cord-298169-2133gahl 88 43 al al NNP cord-298169-2133gahl 88 44 , , , cord-298169-2133gahl 88 45 2019 2019 CD cord-298169-2133gahl 88 46 ) ) -RRB- cord-298169-2133gahl 88 47 . . . cord-298169-2133gahl 89 1 We -PRON- PRP cord-298169-2133gahl 89 2 also also RB cord-298169-2133gahl 89 3 found find VBD cord-298169-2133gahl 89 4 that that IN cord-298169-2133gahl 89 5 two two CD cord-298169-2133gahl 89 6 haplotypes haplotype NNS cord-298169-2133gahl 89 7 namely namely RB cord-298169-2133gahl 89 8 HLA HLA NNP cord-298169-2133gahl 89 9 57.1 57.1 CD cord-298169-2133gahl 89 10 AH AH NNP cord-298169-2133gahl 89 11 and and CC cord-298169-2133gahl 89 12 7.1 7.1 CD cord-298169-2133gahl 89 13 AH AH NNP cord-298169-2133gahl 89 14 were be VBD cord-298169-2133gahl 89 15 specifically specifically RB cord-298169-2133gahl 89 16 associated associate VBN cord-298169-2133gahl 89 17 with with IN cord-298169-2133gahl 89 18 bipolar bipolar JJ cord-298169-2133gahl 89 19 disorder disorder NN cord-298169-2133gahl 89 20 having have VBG cord-298169-2133gahl 89 21 first first JJ cord-298169-2133gahl 89 22 episodes episode NNS cord-298169-2133gahl 89 23 defined define VBN cord-298169-2133gahl 89 24 by by IN cord-298169-2133gahl 89 25 hypomanic hypomanic JJ cord-298169-2133gahl 89 26 episode episode NN cord-298169-2133gahl 89 27 or or CC cord-298169-2133gahl 89 28 psychotic psychotic JJ cord-298169-2133gahl 89 29 symptoms symptom NNS cord-298169-2133gahl 89 30 . . . cord-298169-2133gahl 90 1 This this DT cord-298169-2133gahl 90 2 is be VBZ cord-298169-2133gahl 90 3 of of IN cord-298169-2133gahl 90 4 importance importance NN cord-298169-2133gahl 90 5 as as IN cord-298169-2133gahl 90 6 these these DT cord-298169-2133gahl 90 7 two two CD cord-298169-2133gahl 90 8 haplotypes haplotype NNS cord-298169-2133gahl 90 9 are be VBP cord-298169-2133gahl 90 10 also also RB cord-298169-2133gahl 90 11 linked link VBN cord-298169-2133gahl 90 12 to to IN cord-298169-2133gahl 90 13 common common JJ cord-298169-2133gahl 90 14 inflammatory inflammatory JJ cord-298169-2133gahl 90 15 conditions condition NNS cord-298169-2133gahl 90 16 , , , cord-298169-2133gahl 90 17 and and CC cord-298169-2133gahl 90 18 might may MD cord-298169-2133gahl 90 19 thus thus RB cord-298169-2133gahl 90 20 contribute contribute VB cord-298169-2133gahl 90 21 to to IN cord-298169-2133gahl 90 22 the the DT cord-298169-2133gahl 90 23 proinflammatory proinflammatory JJ cord-298169-2133gahl 90 24 processes process NNS cord-298169-2133gahl 90 25 observed observe VBN cord-298169-2133gahl 90 26 in in IN cord-298169-2133gahl 90 27 bipolar bipolar JJ cord-298169-2133gahl 90 28 disorder disorder NN cord-298169-2133gahl 90 29 . . . cord-298169-2133gahl 91 1 Although although IN cord-298169-2133gahl 91 2 these these DT cord-298169-2133gahl 91 3 data datum NNS cord-298169-2133gahl 91 4 , , , cord-298169-2133gahl 91 5 observed observe VBD cord-298169-2133gahl 91 6 in in IN cord-298169-2133gahl 91 7 phenotypically phenotypically RB cord-298169-2133gahl 91 8 well well RB cord-298169-2133gahl 91 9 - - HYPH cord-298169-2133gahl 91 10 defined define VBN cord-298169-2133gahl 91 11 subgroups subgroup NNS cord-298169-2133gahl 91 12 of of IN cord-298169-2133gahl 91 13 patients patient NNS cord-298169-2133gahl 91 14 , , , cord-298169-2133gahl 91 15 may may MD cord-298169-2133gahl 91 16 constitute constitute VB cord-298169-2133gahl 91 17 interesting interesting JJ cord-298169-2133gahl 91 18 tags tag NNS cord-298169-2133gahl 91 19 of of IN cord-298169-2133gahl 91 20 the the DT cord-298169-2133gahl 91 21 MHC MHC NNP cord-298169-2133gahl 91 22 implication implication NN cord-298169-2133gahl 91 23 in in IN cord-298169-2133gahl 91 24 BD BD NNP cord-298169-2133gahl 91 25 , , , cord-298169-2133gahl 91 26 here here RB cord-298169-2133gahl 91 27 again again RB cord-298169-2133gahl 91 28 , , , cord-298169-2133gahl 91 29 a a DT cord-298169-2133gahl 91 30 recent recent JJ cord-298169-2133gahl 91 31 GWAS GWAS NNP cord-298169-2133gahl 91 32 did do VBD cord-298169-2133gahl 91 33 not not RB cord-298169-2133gahl 91 34 allowed allow VBN cord-298169-2133gahl 91 35 to to TO cord-298169-2133gahl 91 36 uncover uncover VB cord-298169-2133gahl 91 37 any any DT cord-298169-2133gahl 91 38 MHC MHC NNP cord-298169-2133gahl 91 39 - - HYPH cord-298169-2133gahl 91 40 derived derive VBN cord-298169-2133gahl 91 41 signal signal NN cord-298169-2133gahl 91 42 ( ( -LRB- cord-298169-2133gahl 91 43 Stahl Stahl NNP cord-298169-2133gahl 91 44 et et NNP cord-298169-2133gahl 91 45 al al NNP cord-298169-2133gahl 91 46 , , , cord-298169-2133gahl 91 47 2019 2019 CD cord-298169-2133gahl 91 48 ) ) -RRB- cord-298169-2133gahl 91 49 . . . cord-298169-2133gahl 92 1 The the DT cord-298169-2133gahl 92 2 contrasting contrast VBG cord-298169-2133gahl 92 3 effect effect NN cord-298169-2133gahl 92 4 of of IN cord-298169-2133gahl 92 5 8.1 8.1 CD cord-298169-2133gahl 92 6 AH ah NN cord-298169-2133gahl 92 7 , , , cord-298169-2133gahl 92 8 being be VBG cord-298169-2133gahl 92 9 protective protective JJ cord-298169-2133gahl 92 10 in in IN cord-298169-2133gahl 92 11 schizophrenia schizophrenia NN cord-298169-2133gahl 92 12 and and CC cord-298169-2133gahl 92 13 autism autism NN cord-298169-2133gahl 92 14 but but CC cord-298169-2133gahl 92 15 conferring confer VBG cord-298169-2133gahl 92 16 severity severity NN cord-298169-2133gahl 92 17 in in IN cord-298169-2133gahl 92 18 bipolar bipolar JJ cord-298169-2133gahl 92 19 disorder disorder NN cord-298169-2133gahl 92 20 , , , cord-298169-2133gahl 92 21 is be VBZ cord-298169-2133gahl 92 22 interesting interesting JJ cord-298169-2133gahl 92 23 . . . cord-298169-2133gahl 93 1 Andreasen Andreasen NNP cord-298169-2133gahl 93 2 et et NNP cord-298169-2133gahl 93 3 al al NNP cord-298169-2133gahl 93 4 . . . cord-298169-2133gahl 94 1 ( ( -LRB- cord-298169-2133gahl 94 2 2015 2015 CD cord-298169-2133gahl 94 3 ) ) -RRB- cord-298169-2133gahl 94 4 reported report VBD cord-298169-2133gahl 94 5 that that IN cord-298169-2133gahl 94 6 the the DT cord-298169-2133gahl 94 7 same same JJ cord-298169-2133gahl 94 8 HLA HLA NNP cord-298169-2133gahl 94 9 allele allele NN cord-298169-2133gahl 94 10 was be VBD cord-298169-2133gahl 94 11 shared share VBN cord-298169-2133gahl 94 12 between between IN cord-298169-2133gahl 94 13 schizophrenia schizophrenia NN cord-298169-2133gahl 94 14 and and CC cord-298169-2133gahl 94 15 multiple multiple JJ cord-298169-2133gahl 94 16 sclerosis sclerosis NN cord-298169-2133gahl 94 17 ( ( -LRB- cord-298169-2133gahl 94 18 MS MS NNP cord-298169-2133gahl 94 19 ) ) -RRB- cord-298169-2133gahl 94 20 , , , cord-298169-2133gahl 94 21 but but CC cord-298169-2133gahl 94 22 not not RB cord-298169-2133gahl 94 23 between between IN cord-298169-2133gahl 94 24 MS MS NNP cord-298169-2133gahl 94 25 and and CC cord-298169-2133gahl 94 26 BD BD NNP cord-298169-2133gahl 94 27 . . . cord-298169-2133gahl 95 1 Despite despite IN cord-298169-2133gahl 95 2 the the DT cord-298169-2133gahl 95 3 large large JJ cord-298169-2133gahl 95 4 overlaps overlap NNS cord-298169-2133gahl 95 5 of of IN cord-298169-2133gahl 95 6 genetic genetic JJ cord-298169-2133gahl 95 7 as as RB cord-298169-2133gahl 95 8 well well RB cord-298169-2133gahl 95 9 as as IN cord-298169-2133gahl 95 10 clinical clinical JJ cord-298169-2133gahl 95 11 features feature NNS cord-298169-2133gahl 95 12 in in IN cord-298169-2133gahl 95 13 bipolar bipolar JJ cord-298169-2133gahl 95 14 disorder disorder NN cord-298169-2133gahl 95 15 and and CC cord-298169-2133gahl 95 16 schizophrenia schizophrenia NN cord-298169-2133gahl 95 17 , , , cord-298169-2133gahl 95 18 these these DT cord-298169-2133gahl 95 19 data datum NNS cord-298169-2133gahl 95 20 are be VBP cord-298169-2133gahl 95 21 suggestive suggestive JJ cord-298169-2133gahl 95 22 of of IN cord-298169-2133gahl 95 23 temporal temporal JJ cord-298169-2133gahl 95 24 differences difference NNS cord-298169-2133gahl 95 25 in in IN cord-298169-2133gahl 95 26 HLA HLA NNP cord-298169-2133gahl 95 27 - - HYPH cord-298169-2133gahl 95 28 dependent dependent JJ cord-298169-2133gahl 95 29 immunogenetic immunogenetic JJ cord-298169-2133gahl 95 30 influences influence NNS cord-298169-2133gahl 95 31 on on IN cord-298169-2133gahl 95 32 neurodevelopmental neurodevelopmental JJ cord-298169-2133gahl 95 33 processes process NNS cord-298169-2133gahl 95 34 ( ( -LRB- cord-298169-2133gahl 95 35 Andreassen Andreassen NNP cord-298169-2133gahl 95 36 et et NNP cord-298169-2133gahl 95 37 al al NNP cord-298169-2133gahl 95 38 , , , cord-298169-2133gahl 95 39 2015 2015 CD cord-298169-2133gahl 95 40 ; ; : cord-298169-2133gahl 95 41 Bergen Bergen NNP cord-298169-2133gahl 95 42 et et NNP cord-298169-2133gahl 95 43 al al NNP cord-298169-2133gahl 95 44 , , , cord-298169-2133gahl 95 45 2012 2012 CD cord-298169-2133gahl 95 46 ) ) -RRB- cord-298169-2133gahl 95 47 . . . cord-298169-2133gahl 96 1 These these DT cord-298169-2133gahl 96 2 two two CD cord-298169-2133gahl 96 3 psychiatric psychiatric JJ cord-298169-2133gahl 96 4 disorders disorder NNS cord-298169-2133gahl 96 5 may may MD cord-298169-2133gahl 96 6 be be VB cord-298169-2133gahl 96 7 differentiated differentiate VBN cord-298169-2133gahl 96 8 by by IN cord-298169-2133gahl 96 9 opposite opposite JJ cord-298169-2133gahl 96 10 effects effect NNS cord-298169-2133gahl 96 11 mediated mediate VBN cord-298169-2133gahl 96 12 by by IN cord-298169-2133gahl 96 13 the the DT cord-298169-2133gahl 96 14 8.1 8.1 CD cord-298169-2133gahl 96 15 AH ah UH cord-298169-2133gahl 96 16 possibly possibly RB cord-298169-2133gahl 96 17 through through IN cord-298169-2133gahl 96 18 specific specific JJ cord-298169-2133gahl 96 19 complement complement NN cord-298169-2133gahl 96 20 C4-mediated c4-mediate VBD cord-298169-2133gahl 96 21 synaptic synaptic JJ cord-298169-2133gahl 96 22 pruning pruning NN cord-298169-2133gahl 96 23 processes process NNS cord-298169-2133gahl 96 24 . . . cord-298169-2133gahl 97 1 The the DT cord-298169-2133gahl 97 2 role role NN cord-298169-2133gahl 97 3 of of IN cord-298169-2133gahl 97 4 HLA HLA NNP cord-298169-2133gahl 97 5 - - HYPH cord-298169-2133gahl 97 6 driven drive VBN cord-298169-2133gahl 97 7 changes change NNS cord-298169-2133gahl 97 8 to to IN cord-298169-2133gahl 97 9 the the DT cord-298169-2133gahl 97 10 temporal temporal JJ cord-298169-2133gahl 97 11 neurodevelopmental neurodevelopmental JJ cord-298169-2133gahl 97 12 specificities specificity NNS cord-298169-2133gahl 97 13 of of IN cord-298169-2133gahl 97 14 bipolar bipolar JJ cord-298169-2133gahl 97 15 disorder disorder NN cord-298169-2133gahl 97 16 and and CC cord-298169-2133gahl 97 17 schizophrenia schizophrenia NN cord-298169-2133gahl 97 18 will will MD cord-298169-2133gahl 97 19 be be VB cord-298169-2133gahl 97 20 important important JJ cord-298169-2133gahl 97 21 to to TO cord-298169-2133gahl 97 22 clarify clarify VB cord-298169-2133gahl 97 23 in in IN cord-298169-2133gahl 97 24 future future JJ cord-298169-2133gahl 97 25 research research NN cord-298169-2133gahl 97 26 . . . cord-298169-2133gahl 98 1 Beside beside IN cord-298169-2133gahl 98 2 schizophrenia schizophrenia NN cord-298169-2133gahl 98 3 , , , cord-298169-2133gahl 98 4 autism autism NN cord-298169-2133gahl 98 5 spectrum spectrum NN cord-298169-2133gahl 98 6 disorders disorder NNS cord-298169-2133gahl 98 7 and and CC cord-298169-2133gahl 98 8 bipolar bipolar JJ cord-298169-2133gahl 98 9 disorders disorder NNS cord-298169-2133gahl 98 10 , , , cord-298169-2133gahl 98 11 major major JJ cord-298169-2133gahl 98 12 depressive depressive JJ cord-298169-2133gahl 98 13 disorders disorder NNS cord-298169-2133gahl 98 14 and and CC cord-298169-2133gahl 98 15 attention attention NN cord-298169-2133gahl 98 16 deficit deficit NN cord-298169-2133gahl 98 17 hyperactivity hyperactivity NN cord-298169-2133gahl 98 18 disorders disorder NNS cord-298169-2133gahl 98 19 are be VBP cord-298169-2133gahl 98 20 also also RB cord-298169-2133gahl 98 21 major major JJ cord-298169-2133gahl 98 22 , , , cord-298169-2133gahl 98 23 common common JJ cord-298169-2133gahl 98 24 and and CC cord-298169-2133gahl 98 25 frequent frequent JJ cord-298169-2133gahl 98 26 psychiatric psychiatric JJ cord-298169-2133gahl 98 27 conditions condition NNS cord-298169-2133gahl 98 28 but but CC cord-298169-2133gahl 98 29 suffer suffer VBP cord-298169-2133gahl 98 30 from from IN cord-298169-2133gahl 98 31 scarcity scarcity NN cord-298169-2133gahl 98 32 of of IN cord-298169-2133gahl 98 33 published publish VBN cord-298169-2133gahl 98 34 / / SYM cord-298169-2133gahl 98 35 robust robust JJ cord-298169-2133gahl 98 36 data datum NNS cord-298169-2133gahl 98 37 implicating implicate VBG cord-298169-2133gahl 98 38 HLA HLA NNP cord-298169-2133gahl 98 39 genetics genetic NNS cord-298169-2133gahl 98 40 . . . cord-298169-2133gahl 99 1 Concerning concern VBG cord-298169-2133gahl 99 2 major major JJ cord-298169-2133gahl 99 3 depressive depressive JJ cord-298169-2133gahl 99 4 disorders disorder NNS cord-298169-2133gahl 99 5 results result NNS cord-298169-2133gahl 99 6 from from IN cord-298169-2133gahl 99 7 number number NN cord-298169-2133gahl 99 8 of of IN cord-298169-2133gahl 99 9 small small JJ cord-298169-2133gahl 99 10 studies study NNS cord-298169-2133gahl 99 11 , , , cord-298169-2133gahl 99 12 using use VBG cord-298169-2133gahl 99 13 broad broad JJ cord-298169-2133gahl 99 14 serological serological JJ cord-298169-2133gahl 99 15 typing typing NN cord-298169-2133gahl 99 16 ( ( -LRB- cord-298169-2133gahl 99 17 now now RB cord-298169-2133gahl 99 18 considered consider VBN cord-298169-2133gahl 99 19 as as IN cord-298169-2133gahl 99 20 obsolete obsolete JJ cord-298169-2133gahl 99 21 ) ) -RRB- cord-298169-2133gahl 99 22 , , , cord-298169-2133gahl 99 23 generated generate VBD cord-298169-2133gahl 99 24 inconsistent inconsistent JJ cord-298169-2133gahl 99 25 data datum NNS cord-298169-2133gahl 99 26 . . . cord-298169-2133gahl 100 1 Besides besides RB cord-298169-2133gahl 100 2 , , , cord-298169-2133gahl 100 3 a a DT cord-298169-2133gahl 100 4 very very RB cord-298169-2133gahl 100 5 recent recent JJ cord-298169-2133gahl 100 6 GWAS GWAS NNP cord-298169-2133gahl 100 7 failed fail VBD cord-298169-2133gahl 100 8 to to TO cord-298169-2133gahl 100 9 identify identify VB cord-298169-2133gahl 100 10 any any DT cord-298169-2133gahl 100 11 HLA HLA NNP cord-298169-2133gahl 100 12 - - HYPH cord-298169-2133gahl 100 13 related relate VBN cord-298169-2133gahl 100 14 signals signal NNS cord-298169-2133gahl 100 15 in in IN cord-298169-2133gahl 100 16 MDD MDD NNP cord-298169-2133gahl 100 17 ( ( -LRB- cord-298169-2133gahl 100 18 Glanville Glanville NNP cord-298169-2133gahl 100 19 et et NNP cord-298169-2133gahl 100 20 al al NNP cord-298169-2133gahl 100 21 , , , cord-298169-2133gahl 100 22 2020 2020 CD cord-298169-2133gahl 100 23 ) ) -RRB- cord-298169-2133gahl 100 24 . . . cord-298169-2133gahl 101 1 This this DT cord-298169-2133gahl 101 2 is be VBZ cord-298169-2133gahl 101 3 also also RB cord-298169-2133gahl 101 4 true true JJ cord-298169-2133gahl 101 5 for for IN cord-298169-2133gahl 101 6 ADHD ADHD NNP cord-298169-2133gahl 101 7 where where WRB cord-298169-2133gahl 101 8 few few JJ cord-298169-2133gahl 101 9 previous previous JJ cord-298169-2133gahl 101 10 studies study NNS cord-298169-2133gahl 101 11 indicated indicate VBD cord-298169-2133gahl 101 12 potential potential JJ cord-298169-2133gahl 101 13 association association NN cord-298169-2133gahl 101 14 with with IN cord-298169-2133gahl 101 15 the the DT cord-298169-2133gahl 101 16 MHC MHC NNP cord-298169-2133gahl 101 17 non non JJ cord-298169-2133gahl 101 18 - - JJ cord-298169-2133gahl 101 19 classical classical JJ cord-298169-2133gahl 101 20 complement complement NN cord-298169-2133gahl 101 21 C4b c4b NN cord-298169-2133gahl 101 22 , , , cord-298169-2133gahl 101 23 but but CC cord-298169-2133gahl 101 24 again again RB cord-298169-2133gahl 101 25 , , , cord-298169-2133gahl 101 26 a a DT cord-298169-2133gahl 101 27 recent recent JJ cord-298169-2133gahl 101 28 large large JJ cord-298169-2133gahl 101 29 GWAS GWAS NNP cord-298169-2133gahl 101 30 did do VBD cord-298169-2133gahl 101 31 not not RB cord-298169-2133gahl 101 32 allow allow VB cord-298169-2133gahl 101 33 to to TO cord-298169-2133gahl 101 34 detect detect VB cord-298169-2133gahl 101 35 any any DT cord-298169-2133gahl 101 36 association association NN cord-298169-2133gahl 101 37 between between IN cord-298169-2133gahl 101 38 ADHD ADHD NNP cord-298169-2133gahl 101 39 and and CC cord-298169-2133gahl 101 40 HLA HLA NNP cord-298169-2133gahl 101 41 ( ( -LRB- cord-298169-2133gahl 101 42 Nudel Nudel NNP cord-298169-2133gahl 101 43 et et FW cord-298169-2133gahl 101 44 al al NNP cord-298169-2133gahl 101 45 , , , cord-298169-2133gahl 101 46 2019 2019 CD cord-298169-2133gahl 101 47 ) ) -RRB- cord-298169-2133gahl 101 48 . . . cord-298169-2133gahl 102 1 Nevertheless nevertheless RB cord-298169-2133gahl 102 2 , , , cord-298169-2133gahl 102 3 the the DT cord-298169-2133gahl 102 4 potential potential JJ cord-298169-2133gahl 102 5 genetic genetic JJ cord-298169-2133gahl 102 6 association association NN cord-298169-2133gahl 102 7 between between IN cord-298169-2133gahl 102 8 HLA HLA NNP cord-298169-2133gahl 102 9 polymorphism polymorphism NN cord-298169-2133gahl 102 10 and and CC cord-298169-2133gahl 102 11 anti anti JJ cord-298169-2133gahl 102 12 - - JJ cord-298169-2133gahl 102 13 NMDA NMDA NNP cord-298169-2133gahl 102 14 - - HYPH cord-298169-2133gahl 102 15 R R NNP cord-298169-2133gahl 102 16 encephalitis encephalitis RB cord-298169-2133gahl 102 17 awaits await VBZ cord-298169-2133gahl 102 18 confirmation confirmation NN cord-298169-2133gahl 102 19 . . . cord-298169-2133gahl 103 1 More more RBR cord-298169-2133gahl 103 2 consistently consistently RB cord-298169-2133gahl 103 3 , , , cord-298169-2133gahl 103 4 other other JJ cord-298169-2133gahl 103 5 autoantibodies autoantibody NNS cord-298169-2133gahl 103 6 for for IN cord-298169-2133gahl 103 7 brain brain NN cord-298169-2133gahl 103 8 receptor receptor NN cord-298169-2133gahl 103 9 targets target NNS cord-298169-2133gahl 103 10 have have VBP cord-298169-2133gahl 103 11 recently recently RB cord-298169-2133gahl 103 12 been be VBN cord-298169-2133gahl 103 13 described describe VBN cord-298169-2133gahl 103 14 . . . cord-298169-2133gahl 104 1 In in IN cord-298169-2133gahl 104 2 particular particular JJ cord-298169-2133gahl 104 3 , , , cord-298169-2133gahl 104 4 a a DT cord-298169-2133gahl 104 5 German german JJ cord-298169-2133gahl 104 6 study study NN cord-298169-2133gahl 104 7 described describe VBD cord-298169-2133gahl 104 8 a a DT cord-298169-2133gahl 104 9 strong strong JJ cord-298169-2133gahl 104 10 association association NN cord-298169-2133gahl 104 11 between between IN cord-298169-2133gahl 104 12 anti anti JJ cord-298169-2133gahl 104 13 - - JJ cord-298169-2133gahl 104 14 leucine leucine JJ cord-298169-2133gahl 104 15 - - HYPH cord-298169-2133gahl 104 16 rich rich JJ cord-298169-2133gahl 104 17 glioma glioma NN cord-298169-2133gahl 104 18 - - HYPH cord-298169-2133gahl 104 19 inactivated1 inactivated1 NN cord-298169-2133gahl 104 20 ( ( -LRB- cord-298169-2133gahl 104 21 LGI1 LGI1 NNP cord-298169-2133gahl 104 22 ) ) -RRB- cord-298169-2133gahl 104 23 encephalitis encephalitis NN cord-298169-2133gahl 104 24 and and CC cord-298169-2133gahl 104 25 the the DT cord-298169-2133gahl 104 26 HLA HLA NNP cord-298169-2133gahl 104 27 - - HYPH cord-298169-2133gahl 104 28 DRB1 DRB1 NNP cord-298169-2133gahl 104 29 * * NFP cord-298169-2133gahl 104 30 07:01~DQA1 07:01~dqa1 CD cord-298169-2133gahl 104 31 * * NFP cord-298169-2133gahl 104 32 02:01 02:01 CD cord-298169-2133gahl 104 33 haplotype haplotype NN cord-298169-2133gahl 104 34 ( ( -LRB- cord-298169-2133gahl 104 35 Mueller Mueller NNP cord-298169-2133gahl 104 36 et et NNP cord-298169-2133gahl 104 37 al al NNP cord-298169-2133gahl 104 38 , , , cord-298169-2133gahl 104 39 2018 2018 CD cord-298169-2133gahl 104 40 ) ) -RRB- cord-298169-2133gahl 104 41 . . . cord-298169-2133gahl 105 1 In in IN cord-298169-2133gahl 105 2 addition addition NN cord-298169-2133gahl 105 3 , , , cord-298169-2133gahl 105 4 another another DT cord-298169-2133gahl 105 5 study study NN cord-298169-2133gahl 105 6 , , , cord-298169-2133gahl 105 7 besides besides IN cord-298169-2133gahl 105 8 replicating replicate VBG cord-298169-2133gahl 105 9 the the DT cord-298169-2133gahl 105 10 above above RB cord-298169-2133gahl 105 11 - - HYPH cord-298169-2133gahl 105 12 mentioned mention VBN cord-298169-2133gahl 105 13 HLA HLA NNP cord-298169-2133gahl 105 14 association association NN cord-298169-2133gahl 105 15 with with IN cord-298169-2133gahl 105 16 LGI1-mediated LGI1-mediated NNP cord-298169-2133gahl 105 17 encephalitis encephalitis RB cord-298169-2133gahl 105 18 , , , cord-298169-2133gahl 105 19 described describe VBD cord-298169-2133gahl 105 20 an an DT cord-298169-2133gahl 105 21 additional additional JJ cord-298169-2133gahl 105 22 association association NN cord-298169-2133gahl 105 23 between between IN cord-298169-2133gahl 105 24 the the DT cord-298169-2133gahl 105 25 HLA HLA NNP cord-298169-2133gahl 105 26 - - HYPH cord-298169-2133gahl 105 27 DRB1 DRB1 NNP cord-298169-2133gahl 105 28 * * NFP cord-298169-2133gahl 105 29 11:01~DQA1 11:01~dqa1 CD cord-298169-2133gahl 105 30 * * NFP cord-298169-2133gahl 105 31 05:01~DQB1 05:01~DQB1 NFP cord-298169-2133gahl 105 32 * * NFP cord-298169-2133gahl 105 33 03:01 03:01 CD cord-298169-2133gahl 105 34 haplotype haplotype NN cord-298169-2133gahl 105 35 and and CC cord-298169-2133gahl 105 36 anti anti JJ cord-298169-2133gahl 105 37 - - JJ cord-298169-2133gahl 105 38 contactin contactin JJ cord-298169-2133gahl 105 39 - - HYPH cord-298169-2133gahl 105 40 associated associate VBN cord-298169-2133gahl 105 41 protein-2 protein-2 NNPS cord-298169-2133gahl 105 42 ( ( -LRB- cord-298169-2133gahl 105 43 CASPR2 caspr2 NN cord-298169-2133gahl 105 44 ) ) -RRB- cord-298169-2133gahl 105 45 encephalitis encephalitis RB cord-298169-2133gahl 106 1 ( ( -LRB- cord-298169-2133gahl 106 2 Binks Binks NNP cord-298169-2133gahl 106 3 et et NNP cord-298169-2133gahl 106 4 al al NNP cord-298169-2133gahl 106 5 , , , cord-298169-2133gahl 106 6 2018 2018 CD cord-298169-2133gahl 106 7 ) ) -RRB- cord-298169-2133gahl 106 8 . . . cord-298169-2133gahl 106 9 _SP cord-298169-2133gahl 107 1 HLA HLA NNP cord-298169-2133gahl 107 2 genetic genetic JJ cord-298169-2133gahl 107 3 diversity diversity NN cord-298169-2133gahl 107 4 is be VBZ cord-298169-2133gahl 107 5 also also RB cord-298169-2133gahl 107 6 implicated implicate VBN cord-298169-2133gahl 107 7 in in IN cord-298169-2133gahl 107 8 the the DT cord-298169-2133gahl 107 9 modulation modulation NN cord-298169-2133gahl 107 10 of of IN cord-298169-2133gahl 107 11 treatment treatment NN cord-298169-2133gahl 107 12 responses response NNS cord-298169-2133gahl 107 13 in in IN cord-298169-2133gahl 107 14 psychiatric psychiatric JJ cord-298169-2133gahl 107 15 conditions condition NNS cord-298169-2133gahl 107 16 , , , cord-298169-2133gahl 107 17 including include VBG cord-298169-2133gahl 107 18 in in IN cord-298169-2133gahl 107 19 the the DT cord-298169-2133gahl 107 20 regulation regulation NN cord-298169-2133gahl 107 21 of of IN cord-298169-2133gahl 107 22 adverse adverse JJ cord-298169-2133gahl 107 23 drug drug NN cord-298169-2133gahl 107 24 reaction reaction NN cord-298169-2133gahl 107 25 ( ( -LRB- cord-298169-2133gahl 107 26 ADRs adr NNS cord-298169-2133gahl 107 27 ) ) -RRB- cord-298169-2133gahl 107 28 and and CC cord-298169-2133gahl 107 29 treatment treatment NN cord-298169-2133gahl 107 30 efficacy efficacy NN cord-298169-2133gahl 107 31 . . . cord-298169-2133gahl 108 1 Both both DT cord-298169-2133gahl 108 2 candidate candidate NN cord-298169-2133gahl 108 3 gene gene NN cord-298169-2133gahl 108 4 studies study NNS cord-298169-2133gahl 108 5 and and CC cord-298169-2133gahl 108 6 GWAS GWAS NNP cord-298169-2133gahl 108 7 have have VBP cord-298169-2133gahl 108 8 shown show VBN cord-298169-2133gahl 108 9 that that IN cord-298169-2133gahl 108 10 clozapine clozapine NN cord-298169-2133gahl 108 11 - - HYPH cord-298169-2133gahl 108 12 induced induce VBN cord-298169-2133gahl 108 13 agranulocytosis agranulocytosis NN cord-298169-2133gahl 108 14 is be VBZ cord-298169-2133gahl 108 15 partly partly RB cord-298169-2133gahl 108 16 mediated mediate VBN cord-298169-2133gahl 108 17 by by IN cord-298169-2133gahl 108 18 class class NN cord-298169-2133gahl 108 19 I i NN cord-298169-2133gahl 108 20 and and CC cord-298169-2133gahl 108 21 II II NNP cord-298169-2133gahl 108 22 HLA HLA NNP cord-298169-2133gahl 108 23 alleles allele NNS cord-298169-2133gahl 109 1 ( ( -LRB- cord-298169-2133gahl 109 2 Numataa Numataa NNP cord-298169-2133gahl 109 3 et et NNP cord-298169-2133gahl 109 4 al al NNP cord-298169-2133gahl 109 5 , , , cord-298169-2133gahl 109 6 2018 2018 CD cord-298169-2133gahl 109 7 ) ) -RRB- cord-298169-2133gahl 109 8 . . . cord-298169-2133gahl 110 1 In in IN cord-298169-2133gahl 110 2 a a DT cord-298169-2133gahl 110 3 study study NN cord-298169-2133gahl 110 4 of of IN cord-298169-2133gahl 110 5 treatment treatment NN cord-298169-2133gahl 110 6 response response NN cord-298169-2133gahl 110 7 to to IN cord-298169-2133gahl 110 8 antipsychotic antipsychotic NN cord-298169-2133gahl 110 9 , , , cord-298169-2133gahl 110 10 we -PRON- PRP cord-298169-2133gahl 110 11 showed show VBD cord-298169-2133gahl 110 12 that that IN cord-298169-2133gahl 110 13 a a DT cord-298169-2133gahl 110 14 double double JJ cord-298169-2133gahl 110 15 amino amino NN cord-298169-2133gahl 110 16 - - HYPH cord-298169-2133gahl 110 17 acid acid NN cord-298169-2133gahl 110 18 change change NN cord-298169-2133gahl 110 19 in in IN cord-298169-2133gahl 110 20 the the DT cord-298169-2133gahl 110 21 HLA HLA NNP cord-298169-2133gahl 110 22 - - HYPH cord-298169-2133gahl 110 23 A A NNP cord-298169-2133gahl 110 24 peptidebinding peptidebinding NN cord-298169-2133gahl 110 25 groove groove NN cord-298169-2133gahl 110 26 was be VBD cord-298169-2133gahl 110 27 associated associate VBN cord-298169-2133gahl 110 28 with with IN cord-298169-2133gahl 110 29 a a DT cord-298169-2133gahl 110 30 better well JJR cord-298169-2133gahl 110 31 response response NN cord-298169-2133gahl 110 32 to to IN cord-298169-2133gahl 110 33 treatment treatment NN cord-298169-2133gahl 110 34 with with IN cord-298169-2133gahl 110 35 Risperidone Risperidone NNP cord-298169-2133gahl 110 36 in in IN cord-298169-2133gahl 110 37 patients patient NNS cord-298169-2133gahl 110 38 with with IN cord-298169-2133gahl 110 39 schizophrenia schizophrenia NN cord-298169-2133gahl 110 40 ( ( -LRB- cord-298169-2133gahl 110 41 LeClerc LeClerc NNP cord-298169-2133gahl 110 42 et et NNP cord-298169-2133gahl 110 43 al al NNP cord-298169-2133gahl 110 44 , , , cord-298169-2133gahl 110 45 2015 2015 CD cord-298169-2133gahl 110 46 ) ) -RRB- cord-298169-2133gahl 110 47 . . . cord-298169-2133gahl 111 1 A a DT cord-298169-2133gahl 111 2 recent recent JJ cord-298169-2133gahl 111 3 large large JJ cord-298169-2133gahl 111 4 survey survey NN cord-298169-2133gahl 111 5 showed show VBD cord-298169-2133gahl 111 6 that that IN cord-298169-2133gahl 111 7 treatment treatment NN cord-298169-2133gahl 111 8 response response NN cord-298169-2133gahl 111 9 to to IN cord-298169-2133gahl 111 10 lithium lithium NN cord-298169-2133gahl 111 11 in in IN cord-298169-2133gahl 111 12 BD BD NNP cord-298169-2133gahl 111 13 is be VBZ cord-298169-2133gahl 111 14 strongly strongly RB cord-298169-2133gahl 111 15 influenced influence VBN cord-298169-2133gahl 111 16 by by IN cord-298169-2133gahl 111 17 both both DT cord-298169-2133gahl 111 18 schizophrenia schizophrenia NN cord-298169-2133gahl 111 19 - - HYPH cord-298169-2133gahl 111 20 linked link VBN cord-298169-2133gahl 111 21 polygenic polygenic JJ cord-298169-2133gahl 111 22 score score NN cord-298169-2133gahl 111 23 and and CC cord-298169-2133gahl 111 24 the the DT cord-298169-2133gahl 111 25 MHC MHC NNP cord-298169-2133gahl 111 26 / / SYM cord-298169-2133gahl 111 27 HLA HLA NNP cord-298169-2133gahl 111 28 genetic genetic JJ cord-298169-2133gahl 111 29 diversity diversity NN cord-298169-2133gahl 112 1 ( ( -LRB- cord-298169-2133gahl 112 2 Amare Amare NNP cord-298169-2133gahl 112 3 et et NNP cord-298169-2133gahl 112 4 al al NNP cord-298169-2133gahl 112 5 , , , cord-298169-2133gahl 112 6 2018 2018 CD cord-298169-2133gahl 112 7 ) ) -RRB- cord-298169-2133gahl 112 8 . . . cord-298169-2133gahl 113 1 In in IN cord-298169-2133gahl 113 2 the the DT cord-298169-2133gahl 113 3 latter latter JJ cord-298169-2133gahl 113 4 context context NN cord-298169-2133gahl 113 5 the the DT cord-298169-2133gahl 113 6 authors author NNS cord-298169-2133gahl 113 7 identified identify VBD cord-298169-2133gahl 113 8 signals signal NNS cord-298169-2133gahl 113 9 related relate VBN cord-298169-2133gahl 113 10 to to IN cord-298169-2133gahl 113 11 antigen antigen NN cord-298169-2133gahl 113 12 presentation presentation NN cord-298169-2133gahl 113 13 pathway pathway NN cord-298169-2133gahl 113 14 ( ( -LRB- cord-298169-2133gahl 113 15 HLA HLA NNP cord-298169-2133gahl 113 16 - - HYPH cord-298169-2133gahl 113 17 DM DM NNP cord-298169-2133gahl 113 18 region region NN cord-298169-2133gahl 113 19 ) ) -RRB- cord-298169-2133gahl 113 20 , , , cord-298169-2133gahl 113 21 the the DT cord-298169-2133gahl 113 22 main main JJ cord-298169-2133gahl 113 23 function function NN cord-298169-2133gahl 113 24 of of IN cord-298169-2133gahl 113 25 HLA HLA NNP cord-298169-2133gahl 113 26 molecules molecule NNS cord-298169-2133gahl 113 27 . . . cord-298169-2133gahl 114 1 Such such JJ cord-298169-2133gahl 114 2 observation observation NN cord-298169-2133gahl 114 3 could could MD cord-298169-2133gahl 114 4 be be VB cord-298169-2133gahl 114 5 in in IN cord-298169-2133gahl 114 6 line line NN cord-298169-2133gahl 114 7 with with IN cord-298169-2133gahl 114 8 the the DT cord-298169-2133gahl 114 9 notion notion NN cord-298169-2133gahl 114 10 that that IN cord-298169-2133gahl 114 11 differences difference NNS cord-298169-2133gahl 114 12 in in IN cord-298169-2133gahl 114 13 the the DT cord-298169-2133gahl 114 14 heritability heritability NN cord-298169-2133gahl 114 15 between between IN cord-298169-2133gahl 114 16 schizophrenia schizophrenia NN cord-298169-2133gahl 114 17 and and CC cord-298169-2133gahl 114 18 BD BD NNP cord-298169-2133gahl 114 19 may may MD cord-298169-2133gahl 114 20 lie lie VB cord-298169-2133gahl 114 21 in in IN cord-298169-2133gahl 114 22 the the DT cord-298169-2133gahl 114 23 MHC MHC NNP cord-298169-2133gahl 114 24 cluster cluster NN cord-298169-2133gahl 114 25 ( ( -LRB- cord-298169-2133gahl 114 26 Andreassen Andreassen NNP cord-298169-2133gahl 114 27 et et NNP cord-298169-2133gahl 114 28 al al NNP cord-298169-2133gahl 114 29 , , , cord-298169-2133gahl 114 30 2015 2015 CD cord-298169-2133gahl 114 31 ) ) -RRB- cord-298169-2133gahl 114 32 . . . cord-298169-2133gahl 115 1 The the DT cord-298169-2133gahl 115 2 where where WRB cord-298169-2133gahl 115 3 two two CD cord-298169-2133gahl 115 4 types type NNS cord-298169-2133gahl 115 5 of of IN cord-298169-2133gahl 115 6 HERV HERV NNP cord-298169-2133gahl 115 7 family family NN cord-298169-2133gahl 115 8 , , , cord-298169-2133gahl 115 9 namely namely RB cord-298169-2133gahl 115 10 HERV HERV NNP cord-298169-2133gahl 115 11 - - HYPH cord-298169-2133gahl 115 12 W W NNP cord-298169-2133gahl 115 13 and and CC cord-298169-2133gahl 115 14 HERV HERV NNP cord-298169-2133gahl 115 15 - - HYPH cord-298169-2133gahl 115 16 K K NNP cord-298169-2133gahl 115 17 , , , cord-298169-2133gahl 115 18 are be VBP cord-298169-2133gahl 115 19 respectively respectively RB cord-298169-2133gahl 115 20 implicated implicate VBN cord-298169-2133gahl 115 21 ( ( -LRB- cord-298169-2133gahl 115 22 Greenig Greenig NNP cord-298169-2133gahl 115 23 , , , cord-298169-2133gahl 115 24 2019 2019 CD cord-298169-2133gahl 115 25 ) ) -RRB- cord-298169-2133gahl 115 26 . . . cord-298169-2133gahl 116 1 Given give VBN cord-298169-2133gahl 116 2 the the DT cord-298169-2133gahl 116 3 role role NN cord-298169-2133gahl 116 4 of of IN cord-298169-2133gahl 116 5 gene gene NN cord-298169-2133gahl 116 6 and and CC cord-298169-2133gahl 116 7 environment environment NN cord-298169-2133gahl 116 8 interactions interaction NNS cord-298169-2133gahl 116 9 in in IN cord-298169-2133gahl 116 10 HERV HERV NNP cord-298169-2133gahl 116 11 reactivation reactivation NN cord-298169-2133gahl 116 12 , , , cord-298169-2133gahl 116 13 and and CC cord-298169-2133gahl 116 14 its -PRON- PRP$ cord-298169-2133gahl 116 15 capacity capacity NN cord-298169-2133gahl 116 16 to to TO cord-298169-2133gahl 116 17 induce induce VB cord-298169-2133gahl 116 18 pro pro JJ cord-298169-2133gahl 116 19 - - JJ cord-298169-2133gahl 116 20 inflammatory inflammatory JJ cord-298169-2133gahl 116 21 and and CC cord-298169-2133gahl 116 22 neurotoxic neurotoxic JJ cord-298169-2133gahl 116 23 proteins protein NNS cord-298169-2133gahl 116 24 , , , cord-298169-2133gahl 116 25 HERV HERV NNP cord-298169-2133gahl 116 26 has have VBZ cord-298169-2133gahl 116 27 been be VBN cord-298169-2133gahl 116 28 the the DT cord-298169-2133gahl 116 29 focus focus NN cord-298169-2133gahl 116 30 of of IN cord-298169-2133gahl 116 31 studies study NNS cord-298169-2133gahl 116 32 in in IN cord-298169-2133gahl 116 33 psychiatric psychiatric JJ cord-298169-2133gahl 116 34 disorders disorder NNS cord-298169-2133gahl 116 35 . . . cord-298169-2133gahl 117 1 We -PRON- PRP cord-298169-2133gahl 117 2 and and CC cord-298169-2133gahl 117 3 others other NNS cord-298169-2133gahl 117 4 have have VBP cord-298169-2133gahl 117 5 found find VBN cord-298169-2133gahl 117 6 associations association NNS cord-298169-2133gahl 117 7 between between IN cord-298169-2133gahl 117 8 the the DT cord-298169-2133gahl 117 9 HERV HERV NNP cord-298169-2133gahl 117 10 - - HYPH cord-298169-2133gahl 117 11 W w NN cord-298169-2133gahl 117 12 type type NN cord-298169-2133gahl 117 13 and and CC cord-298169-2133gahl 117 14 both both CC cord-298169-2133gahl 117 15 schizophrenia schizophrenia NN cord-298169-2133gahl 117 16 and and CC cord-298169-2133gahl 117 17 BD BD NNP cord-298169-2133gahl 117 18 at at IN cord-298169-2133gahl 117 19 protein protein NN cord-298169-2133gahl 117 20 and/or and/or CC cord-298169-2133gahl 117 21 at at IN cord-298169-2133gahl 117 22 DNA DNA NNP cord-298169-2133gahl 117 23 / / SYM cord-298169-2133gahl 117 24 RNA RNA NNP cord-298169-2133gahl 117 25 levels level NNS cord-298169-2133gahl 117 26 , , , cord-298169-2133gahl 117 27 further further RB cord-298169-2133gahl 117 28 influenced influence VBN cord-298169-2133gahl 117 29 by by IN cord-298169-2133gahl 117 30 copy copy NN cord-298169-2133gahl 117 31 number number NN cord-298169-2133gahl 117 32 variations variation NNS cord-298169-2133gahl 117 33 ( ( -LRB- cord-298169-2133gahl 117 34 Perron Perron NNP cord-298169-2133gahl 117 35 et et NNP cord-298169-2133gahl 117 36 al al NNP cord-298169-2133gahl 117 37 , , , cord-298169-2133gahl 117 38 20121 20121 CD cord-298169-2133gahl 117 39 ; ; : cord-298169-2133gahl 117 40 Leboyer Leboyer NNP cord-298169-2133gahl 117 41 et et NNP cord-298169-2133gahl 117 42 al al NNP cord-298169-2133gahl 117 43 , , , cord-298169-2133gahl 117 44 2013 2013 CD cord-298169-2133gahl 117 45 ) ) -RRB- cord-298169-2133gahl 117 46 . . . cord-298169-2133gahl 118 1 Recent recent JJ cord-298169-2133gahl 118 2 data datum NNS cord-298169-2133gahl 118 3 show show VBP cord-298169-2133gahl 118 4 HERV HERV NNP cord-298169-2133gahl 118 5 - - HYPH cord-298169-2133gahl 118 6 K K NNP cord-298169-2133gahl 118 7 to to TO cord-298169-2133gahl 118 8 be be VB cord-298169-2133gahl 118 9 a a DT cord-298169-2133gahl 118 10 potential potential JJ cord-298169-2133gahl 118 11 risk risk NN cord-298169-2133gahl 118 12 component component NN cord-298169-2133gahl 118 13 for for IN cord-298169-2133gahl 118 14 schizophrenia schizophrenia NNP cord-298169-2133gahl 118 15 . . . cord-298169-2133gahl 119 1 It -PRON- PRP cord-298169-2133gahl 119 2 is be VBZ cord-298169-2133gahl 119 3 worth worth JJ cord-298169-2133gahl 119 4 mentioning mention VBG cord-298169-2133gahl 119 5 that that IN cord-298169-2133gahl 119 6 Sekar Sekar NNP cord-298169-2133gahl 119 7 et et NNP cord-298169-2133gahl 119 8 al al NNP cord-298169-2133gahl 119 9 demonstrated demonstrate VBD cord-298169-2133gahl 119 10 that that IN cord-298169-2133gahl 119 11 complement complement NN cord-298169-2133gahl 119 12 C4 c4 NN cord-298169-2133gahl 119 13 long long JJ cord-298169-2133gahl 119 14 allele allele NN cord-298169-2133gahl 119 15 , , , cord-298169-2133gahl 119 16 harboring harbor VBG cord-298169-2133gahl 119 17 insertion insertion NN cord-298169-2133gahl 119 18 of of IN cord-298169-2133gahl 119 19 HERV HERV NNP cord-298169-2133gahl 119 20 - - HYPH cord-298169-2133gahl 119 21 K K NNP cord-298169-2133gahl 119 22 , , , cord-298169-2133gahl 119 23 expressed express VBD cord-298169-2133gahl 119 24 higher high JJR cord-298169-2133gahl 119 25 levels level NNS cord-298169-2133gahl 119 26 of of IN cord-298169-2133gahl 119 27 C4A c4a CD cord-298169-2133gahl 119 28 molecules molecule NNS cord-298169-2133gahl 119 29 , , , cord-298169-2133gahl 119 30 thereby thereby RB cord-298169-2133gahl 119 31 increasing increase VBG cord-298169-2133gahl 119 32 the the DT cord-298169-2133gahl 119 33 risk risk NN cord-298169-2133gahl 119 34 of of IN cord-298169-2133gahl 119 35 exaggerated exaggerated JJ cord-298169-2133gahl 119 36 synaptic synaptic JJ cord-298169-2133gahl 119 37 pruning pruning NN cord-298169-2133gahl 119 38 , , , cord-298169-2133gahl 119 39 cortical cortical JJ cord-298169-2133gahl 119 40 thinning thinning NN cord-298169-2133gahl 119 41 and and CC cord-298169-2133gahl 119 42 early early JJ cord-298169-2133gahl 119 43 onset onset NN cord-298169-2133gahl 120 1 ( ( -LRB- cord-298169-2133gahl 120 2 Sekar Sekar NNP cord-298169-2133gahl 120 3 et et NNP cord-298169-2133gahl 120 4 al al NNP cord-298169-2133gahl 120 5 , , , cord-298169-2133gahl 120 6 2016 2016 CD cord-298169-2133gahl 120 7 ) ) -RRB- cord-298169-2133gahl 120 8 . . . cord-298169-2133gahl 121 1 This this DT cord-298169-2133gahl 121 2 is be VBZ cord-298169-2133gahl 121 3 an an DT cord-298169-2133gahl 121 4 interesting interesting JJ cord-298169-2133gahl 121 5 area area NN cord-298169-2133gahl 121 6 of of IN cord-298169-2133gahl 121 7 investigation investigation NN cord-298169-2133gahl 121 8 as as IN cord-298169-2133gahl 121 9 clearly clearly RB cord-298169-2133gahl 121 10 different different JJ cord-298169-2133gahl 121 11 HERV HERV NNP cord-298169-2133gahl 121 12 family family NN cord-298169-2133gahl 121 13 members member NNS cord-298169-2133gahl 121 14 can can MD cord-298169-2133gahl 121 15 be be VB cord-298169-2133gahl 121 16 associated associate VBN cord-298169-2133gahl 121 17 with with IN cord-298169-2133gahl 121 18 the the DT cord-298169-2133gahl 121 19 same same JJ cord-298169-2133gahl 121 20 disease disease NN cord-298169-2133gahl 121 21 , , , cord-298169-2133gahl 121 22 although although IN cord-298169-2133gahl 121 23 with with IN cord-298169-2133gahl 121 24 different different JJ cord-298169-2133gahl 121 25 disease disease NN cord-298169-2133gahl 121 26 pathways pathway NNS cord-298169-2133gahl 121 27 . . . cord-298169-2133gahl 122 1 All all DT cord-298169-2133gahl 122 2 living live VBG cord-298169-2133gahl 122 3 organisms organism NNS cord-298169-2133gahl 122 4 have have VBP cord-298169-2133gahl 122 5 to to TO cord-298169-2133gahl 122 6 constantly constantly RB cord-298169-2133gahl 122 7 learnt learn VBN cord-298169-2133gahl 122 8 to to TO cord-298169-2133gahl 122 9 deal deal VB cord-298169-2133gahl 122 10 with with IN cord-298169-2133gahl 122 11 environmental environmental JJ cord-298169-2133gahl 122 12 insults insult NNS cord-298169-2133gahl 122 13 in in IN cord-298169-2133gahl 122 14 order order NN cord-298169-2133gahl 122 15 to to TO cord-298169-2133gahl 122 16 survive survive VB cord-298169-2133gahl 122 17 , , , cord-298169-2133gahl 122 18 including include VBG cord-298169-2133gahl 122 19 various various JJ cord-298169-2133gahl 122 20 types type NNS cord-298169-2133gahl 122 21 of of IN cord-298169-2133gahl 122 22 pathogens pathogen NNS cord-298169-2133gahl 122 23 . . . cord-298169-2133gahl 123 1 Given give VBN cord-298169-2133gahl 123 2 the the DT cord-298169-2133gahl 123 3 extreme extreme JJ cord-298169-2133gahl 123 4 diversity diversity NN cord-298169-2133gahl 123 5 of of IN cord-298169-2133gahl 123 6 these these DT cord-298169-2133gahl 123 7 environmental environmental JJ cord-298169-2133gahl 123 8 insults insult NNS cord-298169-2133gahl 123 9 , , , cord-298169-2133gahl 123 10 evolutionary evolutionary JJ cord-298169-2133gahl 123 11 forces force NNS cord-298169-2133gahl 123 12 have have VBP cord-298169-2133gahl 123 13 gradually gradually RB cord-298169-2133gahl 123 14 shaped shape VBN cord-298169-2133gahl 123 15 powerful powerful JJ cord-298169-2133gahl 123 16 biological biological JJ cord-298169-2133gahl 123 17 systems system NNS cord-298169-2133gahl 123 18 characterized characterize VBN cord-298169-2133gahl 123 19 by by IN cord-298169-2133gahl 123 20 a a DT cord-298169-2133gahl 123 21 large large JJ cord-298169-2133gahl 123 22 number number NN cord-298169-2133gahl 123 23 of of IN cord-298169-2133gahl 123 24 genes gene NNS cord-298169-2133gahl 123 25 with with IN cord-298169-2133gahl 123 26 high high JJ cord-298169-2133gahl 123 27 allelic allelic JJ cord-298169-2133gahl 123 28 diversity diversity NN cord-298169-2133gahl 123 29 adapted adapt VBN cord-298169-2133gahl 123 30 to to TO cord-298169-2133gahl 123 31 handle handle VB cord-298169-2133gahl 123 32 these these DT cord-298169-2133gahl 123 33 challenges challenge NNS cord-298169-2133gahl 123 34 , , , cord-298169-2133gahl 123 35 viz viz VBP cord-298169-2133gahl 123 36 the the DT cord-298169-2133gahl 123 37 different different JJ cord-298169-2133gahl 123 38 wings wing NNS cord-298169-2133gahl 123 39 of of IN cord-298169-2133gahl 123 40 the the DT cord-298169-2133gahl 123 41 immune immune JJ cord-298169-2133gahl 123 42 system system NN cord-298169-2133gahl 123 43 . . . cord-298169-2133gahl 124 1 Upon upon IN cord-298169-2133gahl 124 2 interaction interaction NN cord-298169-2133gahl 124 3 with with IN cord-298169-2133gahl 124 4 a a DT cord-298169-2133gahl 124 5 given give VBN cord-298169-2133gahl 124 6 trigger trigger NN cord-298169-2133gahl 124 7 , , , cord-298169-2133gahl 124 8 the the DT cord-298169-2133gahl 124 9 immune immune JJ cord-298169-2133gahl 124 10 system system NN cord-298169-2133gahl 124 11 first first RB cord-298169-2133gahl 124 12 mounts mount VBZ cord-298169-2133gahl 124 13 non non JJ cord-298169-2133gahl 124 14 - - JJ cord-298169-2133gahl 124 15 specific specific JJ cord-298169-2133gahl 124 16 pro pro JJ cord-298169-2133gahl 124 17 - - JJ cord-298169-2133gahl 124 18 inflammatory inflammatory JJ cord-298169-2133gahl 124 19 processes process NNS cord-298169-2133gahl 124 20 and and CC cord-298169-2133gahl 124 21 then then RB cord-298169-2133gahl 124 22 , , , cord-298169-2133gahl 124 23 if if IN cord-298169-2133gahl 124 24 necessary necessary JJ cord-298169-2133gahl 124 25 , , , cord-298169-2133gahl 124 26 more more RBR cord-298169-2133gahl 124 27 adaptive adaptive JJ cord-298169-2133gahl 124 28 cellular cellular JJ cord-298169-2133gahl 124 29 processes process NNS cord-298169-2133gahl 124 30 directed direct VBN cord-298169-2133gahl 124 31 against against IN cord-298169-2133gahl 124 32 the the DT cord-298169-2133gahl 124 33 triggering trigger VBG cord-298169-2133gahl 124 34 event event NN cord-298169-2133gahl 124 35 . . . cord-298169-2133gahl 125 1 In in IN cord-298169-2133gahl 125 2 parallel parallel NN cord-298169-2133gahl 125 3 with with IN cord-298169-2133gahl 125 4 the the DT cord-298169-2133gahl 125 5 shaping shaping NN cord-298169-2133gahl 125 6 of of IN cord-298169-2133gahl 125 7 the the DT cord-298169-2133gahl 125 8 immune immune JJ cord-298169-2133gahl 125 9 response response NN cord-298169-2133gahl 125 10 , , , cord-298169-2133gahl 125 11 counteracting counteract VBG cord-298169-2133gahl 125 12 immune immune JJ cord-298169-2133gahl 125 13 - - HYPH cord-298169-2133gahl 125 14 modulatory modulatory JJ cord-298169-2133gahl 125 15 genetic genetic JJ cord-298169-2133gahl 125 16 strategies strategy NNS cord-298169-2133gahl 125 17 , , , cord-298169-2133gahl 125 18 limiting limit VBG cord-298169-2133gahl 125 19 uncontrolled uncontrolled JJ cord-298169-2133gahl 125 20 inflammation inflammation NN cord-298169-2133gahl 125 21 , , , cord-298169-2133gahl 125 22 have have VBP cord-298169-2133gahl 125 23 emerged emerge VBN cord-298169-2133gahl 125 24 and and CC cord-298169-2133gahl 125 25 have have VBP cord-298169-2133gahl 125 26 been be VBN cord-298169-2133gahl 125 27 positively positively RB cord-298169-2133gahl 125 28 selected select VBN cord-298169-2133gahl 125 29 by by IN cord-298169-2133gahl 125 30 evolutionary evolutionary JJ cord-298169-2133gahl 125 31 constraints constraint NNS cord-298169-2133gahl 125 32 . . . cord-298169-2133gahl 126 1 The the DT cord-298169-2133gahl 126 2 HLA HLA NNP cord-298169-2133gahl 126 3 - - HYPH cord-298169-2133gahl 126 4 class class NN cord-298169-2133gahl 126 5 I i NN cord-298169-2133gahl 126 6 classical classical JJ cord-298169-2133gahl 126 7 and and CC cord-298169-2133gahl 126 8 non non JJ cord-298169-2133gahl 126 9 - - JJ cord-298169-2133gahl 126 10 classical classical JJ cord-298169-2133gahl 126 11 molecules molecule NNS cord-298169-2133gahl 126 12 represent represent VBP cord-298169-2133gahl 126 13 one one CD cord-298169-2133gahl 126 14 of of IN cord-298169-2133gahl 126 15 the the DT cord-298169-2133gahl 126 16 best good JJS cord-298169-2133gahl 126 17 examples example NNS cord-298169-2133gahl 126 18 of of IN cord-298169-2133gahl 126 19 such such JJ cord-298169-2133gahl 126 20 Janus Janus NNP cord-298169-2133gahl 126 21 - - HYPH cord-298169-2133gahl 126 22 faced face VBN cord-298169-2133gahl 126 23 system system NN cord-298169-2133gahl 126 24 . . . cord-298169-2133gahl 127 1 Indeed indeed RB cord-298169-2133gahl 127 2 , , , cord-298169-2133gahl 127 3 within within IN cord-298169-2133gahl 127 4 the the DT cord-298169-2133gahl 127 5 same same JJ cord-298169-2133gahl 127 6 HLA HLA NNP cord-298169-2133gahl 127 7 - - HYPH cord-298169-2133gahl 127 8 class class NN cord-298169-2133gahl 127 9 I i NN cord-298169-2133gahl 127 10 region region NN cord-298169-2133gahl 127 11 lie lie NN cord-298169-2133gahl 127 12 ( ( -LRB- cord-298169-2133gahl 127 13 i i NN cord-298169-2133gahl 127 14 ) ) -RRB- cord-298169-2133gahl 127 15 the the DT cord-298169-2133gahl 127 16 classical classical JJ cord-298169-2133gahl 127 17 HLAclass HLAclass NNP cord-298169-2133gahl 128 1 I -PRON- PRP cord-298169-2133gahl 128 2 -A -A VBZ cord-298169-2133gahl 128 3 , , , cord-298169-2133gahl 128 4 -B -b ADD cord-298169-2133gahl 128 5 and and CC cord-298169-2133gahl 128 6 -C -C VBZ cord-298169-2133gahl 128 7 loci locus NNS cord-298169-2133gahl 128 8 , , , cord-298169-2133gahl 128 9 characterized characterize VBN cord-298169-2133gahl 128 10 by by IN cord-298169-2133gahl 128 11 an an DT cord-298169-2133gahl 128 12 extreme extreme JJ cord-298169-2133gahl 128 13 polymorphism polymorphism NN cord-298169-2133gahl 128 14 essential essential JJ cord-298169-2133gahl 128 15 for for IN cord-298169-2133gahl 128 16 their -PRON- PRP$ cord-298169-2133gahl 128 17 antigenpresentation antigenpresentation NN cord-298169-2133gahl 128 18 functions function NNS cord-298169-2133gahl 128 19 , , , cord-298169-2133gahl 128 20 and and CC cord-298169-2133gahl 128 21 maintained maintain VBN cord-298169-2133gahl 128 22 by by IN cord-298169-2133gahl 128 23 balancing balance VBG cord-298169-2133gahl 128 24 selection selection NN cord-298169-2133gahl 128 25 ( ( -LRB- cord-298169-2133gahl 128 26 heterozygote heterozygote NN cord-298169-2133gahl 128 27 advantage advantage NN cord-298169-2133gahl 128 28 ) ) -RRB- cord-298169-2133gahl 128 29 to to TO cord-298169-2133gahl 128 30 cope cope VB cord-298169-2133gahl 128 31 up up RP cord-298169-2133gahl 128 32 with with IN cord-298169-2133gahl 128 33 a a DT cord-298169-2133gahl 128 34 large large JJ cord-298169-2133gahl 128 35 variety variety NN cord-298169-2133gahl 128 36 of of IN cord-298169-2133gahl 128 37 environmental environmental JJ cord-298169-2133gahl 128 38 pathogens pathogen NNS cord-298169-2133gahl 128 39 and and CC cord-298169-2133gahl 128 40 ( ( -LRB- cord-298169-2133gahl 128 41 ii ii NN cord-298169-2133gahl 128 42 ) ) -RRB- cord-298169-2133gahl 128 43 the the DT cord-298169-2133gahl 128 44 non non JJ cord-298169-2133gahl 128 45 - - JJ cord-298169-2133gahl 128 46 classical classical JJ cord-298169-2133gahl 128 47 HLA HLA NNP cord-298169-2133gahl 128 48 - - HYPH cord-298169-2133gahl 128 49 E E NNP cord-298169-2133gahl 128 50 , , , cord-298169-2133gahl 128 51 G G NNP cord-298169-2133gahl 128 52 and and CC cord-298169-2133gahl 128 53 F F NNP cord-298169-2133gahl 128 54 genes gene NNS cord-298169-2133gahl 128 55 , , , cord-298169-2133gahl 128 56 remarkable remarkable JJ cord-298169-2133gahl 128 57 due due IN cord-298169-2133gahl 128 58 to to IN cord-298169-2133gahl 128 59 a a DT cord-298169-2133gahl 128 60 very very RB cord-298169-2133gahl 128 61 low low JJ cord-298169-2133gahl 128 62 rate rate NN cord-298169-2133gahl 128 63 of of IN cord-298169-2133gahl 128 64 diversity diversity NN cord-298169-2133gahl 128 65 that that WDT cord-298169-2133gahl 128 66 reflect reflect VBP cord-298169-2133gahl 128 67 broader broad JJR cord-298169-2133gahl 128 68 properties property NNS cord-298169-2133gahl 128 69 , , , cord-298169-2133gahl 128 70 such such JJ cord-298169-2133gahl 128 71 as as IN cord-298169-2133gahl 128 72 immunomodulation immunomodulation NN cord-298169-2133gahl 128 73 . . . cord-298169-2133gahl 129 1 Among among IN cord-298169-2133gahl 129 2 the the DT cord-298169-2133gahl 129 3 latter latter JJ cord-298169-2133gahl 129 4 , , , cord-298169-2133gahl 129 5 the the DT cord-298169-2133gahl 129 6 non non JJ cord-298169-2133gahl 129 7 - - JJ cord-298169-2133gahl 129 8 classical classical JJ cord-298169-2133gahl 129 9 HLA HLA NNP cord-298169-2133gahl 129 10 - - HYPH cord-298169-2133gahl 129 11 G g NN cord-298169-2133gahl 129 12 encode encode VB cord-298169-2133gahl 129 13 cell cell NN cord-298169-2133gahl 129 14 surface surface NN cord-298169-2133gahl 129 15 molecules molecule NNS cord-298169-2133gahl 129 16 exerting exert VBG cord-298169-2133gahl 129 17 powerful powerful JJ cord-298169-2133gahl 129 18 immunomodulatory immunomodulatory JJ cord-298169-2133gahl 129 19 functions function NNS cord-298169-2133gahl 129 20 , , , cord-298169-2133gahl 129 21 demonstrated demonstrate VBD cord-298169-2133gahl 129 22 to to TO cord-298169-2133gahl 129 23 be be VB cord-298169-2133gahl 129 24 essential essential JJ cord-298169-2133gahl 129 25 for for IN cord-298169-2133gahl 129 26 the the DT cord-298169-2133gahl 129 27 establishment establishment NN cord-298169-2133gahl 129 28 and and CC cord-298169-2133gahl 129 29 tolerance tolerance NN cord-298169-2133gahl 129 30 between between IN cord-298169-2133gahl 129 31 the the DT cord-298169-2133gahl 129 32 maternal maternal JJ cord-298169-2133gahl 129 33 immune immune JJ cord-298169-2133gahl 129 34 system system NN cord-298169-2133gahl 129 35 and and CC cord-298169-2133gahl 129 36 the the DT cord-298169-2133gahl 129 37 semi semi JJ cord-298169-2133gahl 129 38 - - JJ cord-298169-2133gahl 129 39 allogeneic allogeneic JJ cord-298169-2133gahl 129 40 fetus fetus NN cord-298169-2133gahl 129 41 at at IN cord-298169-2133gahl 129 42 the the DT cord-298169-2133gahl 129 43 fetal fetal JJ cord-298169-2133gahl 129 44 - - HYPH cord-298169-2133gahl 129 45 placental placental NN cord-298169-2133gahl 129 46 interface interface NN cord-298169-2133gahl 129 47 ( ( -LRB- cord-298169-2133gahl 129 48 Ferreira Ferreira NNP cord-298169-2133gahl 129 49 et et NNP cord-298169-2133gahl 129 50 al al NNP cord-298169-2133gahl 129 51 , , , cord-298169-2133gahl 129 52 2017 2017 CD cord-298169-2133gahl 129 53 ) ) -RRB- cord-298169-2133gahl 129 54 . . . cord-298169-2133gahl 130 1 genetically genetically RB cord-298169-2133gahl 130 2 determined determine VBN cord-298169-2133gahl 130 3 low low JJ cord-298169-2133gahl 130 4 expression expression NN cord-298169-2133gahl 130 5 of of IN cord-298169-2133gahl 130 6 the the DT cord-298169-2133gahl 130 7 tolerogenic tolerogenic NNP cord-298169-2133gahl 130 8 HLA HLA NNP cord-298169-2133gahl 130 9 - - HYPH cord-298169-2133gahl 130 10 G G NNP cord-298169-2133gahl 130 11 molecules molecule NNS cord-298169-2133gahl 130 12 at at IN cord-298169-2133gahl 130 13 the the DT cord-298169-2133gahl 130 14 fetal fetal JJ cord-298169-2133gahl 130 15 - - HYPH cord-298169-2133gahl 130 16 mother mother NN cord-298169-2133gahl 130 17 interface interface NN cord-298169-2133gahl 130 18 , , , cord-298169-2133gahl 130 19 possibly possibly RB cord-298169-2133gahl 130 20 led lead VBN cord-298169-2133gahl 130 21 to to IN cord-298169-2133gahl 130 22 prenatal prenatal JJ cord-298169-2133gahl 130 23 immune immune JJ cord-298169-2133gahl 130 24 activation activation NN cord-298169-2133gahl 130 25 , , , cord-298169-2133gahl 130 26 is be VBZ cord-298169-2133gahl 130 27 associated associate VBN cord-298169-2133gahl 130 28 with with IN cord-298169-2133gahl 130 29 ASD ASD NNP cord-298169-2133gahl 130 30 risk risk NN cord-298169-2133gahl 131 1 ( ( -LRB- cord-298169-2133gahl 131 2 Guerini Guerini NNP cord-298169-2133gahl 131 3 et et NNP cord-298169-2133gahl 131 4 al al NNP cord-298169-2133gahl 131 5 , , , cord-298169-2133gahl 131 6 2015 2015 CD cord-298169-2133gahl 132 1 ( ( -LRB- cord-298169-2133gahl 132 2 Guerini Guerini NNP cord-298169-2133gahl 132 3 et et NNP cord-298169-2133gahl 132 4 al al NNP cord-298169-2133gahl 132 5 , , , cord-298169-2133gahl 132 6 , , , cord-298169-2133gahl 132 7 2018a 2018a CD cord-298169-2133gahl 133 1 ( ( -LRB- cord-298169-2133gahl 133 2 Guerini Guerini NNP cord-298169-2133gahl 133 3 et et NNP cord-298169-2133gahl 133 4 al al NNP cord-298169-2133gahl 133 5 , , , cord-298169-2133gahl 133 6 , , , cord-298169-2133gahl 133 7 2018b 2018b CD cord-298169-2133gahl 134 1 ( ( -LRB- cord-298169-2133gahl 134 2 Guerini Guerini NNP cord-298169-2133gahl 134 3 et et NNP cord-298169-2133gahl 134 4 al al NNP cord-298169-2133gahl 134 5 , , , cord-298169-2133gahl 134 6 , , , cord-298169-2133gahl 134 7 2019 2019 CD cord-298169-2133gahl 134 8 . . . cord-298169-2133gahl 135 1 Schizophrenia schizophrenia NN cord-298169-2133gahl 135 2 is be VBZ cord-298169-2133gahl 135 3 also also RB cord-298169-2133gahl 135 4 widely widely RB cord-298169-2133gahl 135 5 believed believe VBN cord-298169-2133gahl 135 6 to to TO cord-298169-2133gahl 135 7 be be VB cord-298169-2133gahl 135 8 a a DT cord-298169-2133gahl 135 9 neurodevelopmental neurodevelopmental JJ cord-298169-2133gahl 135 10 psychiatric psychiatric JJ cord-298169-2133gahl 135 11 disorder disorder NN cord-298169-2133gahl 135 12 , , , cord-298169-2133gahl 135 13 although although IN cord-298169-2133gahl 135 14 the the DT cord-298169-2133gahl 135 15 role role NN cord-298169-2133gahl 135 16 of of IN cord-298169-2133gahl 135 17 HLA HLA NNP cord-298169-2133gahl 135 18 - - HYPH cord-298169-2133gahl 135 19 G g NN cord-298169-2133gahl 135 20 polymorphism polymorphism NN cord-298169-2133gahl 135 21 and and CC cord-298169-2133gahl 135 22 expression expression NN cord-298169-2133gahl 135 23 has have VBZ cord-298169-2133gahl 135 24 been be VBN cord-298169-2133gahl 135 25 less less RBR cord-298169-2133gahl 135 26 investigated investigate VBN cord-298169-2133gahl 135 27 . . . cord-298169-2133gahl 136 1 However however RB cord-298169-2133gahl 136 2 , , , cord-298169-2133gahl 136 3 available available JJ cord-298169-2133gahl 136 4 data datum NNS cord-298169-2133gahl 136 5 does do VBZ cord-298169-2133gahl 136 6 indicate indicate VB cord-298169-2133gahl 136 7 that that IN cord-298169-2133gahl 136 8 low low JJ cord-298169-2133gahl 136 9 levels level NNS cord-298169-2133gahl 136 10 of of IN cord-298169-2133gahl 136 11 HLA HLA NNP cord-298169-2133gahl 136 12 - - HYPH cord-298169-2133gahl 136 13 G G NNP cord-298169-2133gahl 136 14 , , , cord-298169-2133gahl 136 15 either either CC cord-298169-2133gahl 136 16 circulating circulate VBG cord-298169-2133gahl 136 17 or or CC cord-298169-2133gahl 136 18 genetically genetically RB cord-298169-2133gahl 136 19 determined determined JJ cord-298169-2133gahl 136 20 , , , cord-298169-2133gahl 136 21 may may MD cord-298169-2133gahl 136 22 influence influence VB cord-298169-2133gahl 136 23 disease disease NN cord-298169-2133gahl 136 24 onset onset NN cord-298169-2133gahl 136 25 and and CC cord-298169-2133gahl 136 26 phenotype phenotype NN cord-298169-2133gahl 136 27 ( ( -LRB- cord-298169-2133gahl 136 28 Rajasekaran Rajasekaran NNP cord-298169-2133gahl 136 29 et et FW cord-298169-2133gahl 136 30 al al NNP cord-298169-2133gahl 136 31 , , , cord-298169-2133gahl 136 32 2015 2015 CD cord-298169-2133gahl 136 33 , , , cord-298169-2133gahl 136 34 Rajasekaran Rajasekaran NNP cord-298169-2133gahl 136 35 et et NNP cord-298169-2133gahl 136 36 al al NNP cord-298169-2133gahl 136 37 , , , cord-298169-2133gahl 136 38 2016 2016 CD cord-298169-2133gahl 136 39 Rajasekaran Rajasekaran NNP cord-298169-2133gahl 136 40 et et NNP cord-298169-2133gahl 136 41 al al NNP cord-298169-2133gahl 136 42 , , , cord-298169-2133gahl 136 43 2016 2016 CD cord-298169-2133gahl 136 44 ; ; : cord-298169-2133gahl 136 45 Shivakumar Shivakumar NNP cord-298169-2133gahl 136 46 et et NNP cord-298169-2133gahl 136 47 al al NNP cord-298169-2133gahl 136 48 , , , cord-298169-2133gahl 136 49 2018 2018 CD cord-298169-2133gahl 136 50 ) ) -RRB- cord-298169-2133gahl 136 51 . . . cord-298169-2133gahl 137 1 In in IN cord-298169-2133gahl 137 2 two two CD cord-298169-2133gahl 137 3 studies study NNS cord-298169-2133gahl 137 4 performed perform VBN cord-298169-2133gahl 137 5 on on IN cord-298169-2133gahl 137 6 bipolar bipolar JJ cord-298169-2133gahl 137 7 disorder disorder NN cord-298169-2133gahl 137 8 patient patient NN cord-298169-2133gahl 137 9 populations population NNS cord-298169-2133gahl 137 10 of of IN cord-298169-2133gahl 137 11 distant distant JJ cord-298169-2133gahl 137 12 ethnicity ethnicity NN cord-298169-2133gahl 137 13 , , , cord-298169-2133gahl 137 14 namely namely RB cord-298169-2133gahl 137 15 French french JJ cord-298169-2133gahl 137 16 and and CC cord-298169-2133gahl 137 17 south south JJ cord-298169-2133gahl 137 18 Indian indian JJ cord-298169-2133gahl 137 19 Tamils Tamils NNPS cord-298169-2133gahl 137 20 , , , cord-298169-2133gahl 137 21 data datum NNS cord-298169-2133gahl 137 22 shows show VBZ cord-298169-2133gahl 137 23 that that IN cord-298169-2133gahl 137 24 in in IN cord-298169-2133gahl 137 25 contrast contrast NN cord-298169-2133gahl 137 26 to to IN cord-298169-2133gahl 137 27 autism autism NN cord-298169-2133gahl 137 28 and and CC cord-298169-2133gahl 137 29 schizophrenia schizophrenia NN cord-298169-2133gahl 137 30 , , , cord-298169-2133gahl 137 31 genetically genetically RB cord-298169-2133gahl 137 32 determined determine VBN cord-298169-2133gahl 137 33 HLA HLA NNP cord-298169-2133gahl 137 34 - - HYPH cord-298169-2133gahl 137 35 G g NN cord-298169-2133gahl 137 36 low low JJ cord-298169-2133gahl 137 37 expression expression NN cord-298169-2133gahl 137 38 confers confer VBZ cord-298169-2133gahl 137 39 protection protection NN cord-298169-2133gahl 137 40 against against IN cord-298169-2133gahl 137 41 bipolar bipolar JJ cord-298169-2133gahl 137 42 disorder disorder NN cord-298169-2133gahl 137 43 , , , cord-298169-2133gahl 137 44 suggesting suggest VBG cord-298169-2133gahl 137 45 the the DT cord-298169-2133gahl 137 46 role role NN cord-298169-2133gahl 137 47 of of IN cord-298169-2133gahl 137 48 distinct distinct JJ cord-298169-2133gahl 137 49 HLA HLA NNP cord-298169-2133gahl 137 50 - - HYPH cord-298169-2133gahl 137 51 G g NN cord-298169-2133gahl 137 52 effects effect NNS cord-298169-2133gahl 137 53 in in IN cord-298169-2133gahl 137 54 the the DT cord-298169-2133gahl 137 55 aetiology aetiology NN cord-298169-2133gahl 137 56 of of IN cord-298169-2133gahl 137 57 these these DT cord-298169-2133gahl 137 58 disorders disorder NNS cord-298169-2133gahl 137 59 ( ( -LRB- cord-298169-2133gahl 137 60 Debnath Debnath NNP cord-298169-2133gahl 137 61 et et NNP cord-298169-2133gahl 137 62 al al NNP cord-298169-2133gahl 137 63 , , , cord-298169-2133gahl 137 64 2013 2013 CD cord-298169-2133gahl 137 65 ; ; : cord-298169-2133gahl 137 66 Sundaresh Sundaresh NNP cord-298169-2133gahl 137 67 et et FW cord-298169-2133gahl 137 68 al al NNP cord-298169-2133gahl 137 69 , , , cord-298169-2133gahl 137 70 2018 2018 CD cord-298169-2133gahl 137 71 ) ) -RRB- cord-298169-2133gahl 137 72 . . . cord-298169-2133gahl 138 1 It -PRON- PRP cord-298169-2133gahl 138 2 is be VBZ cord-298169-2133gahl 138 3 hence hence RB cord-298169-2133gahl 138 4 possible possible JJ cord-298169-2133gahl 138 5 that that IN cord-298169-2133gahl 138 6 in in IN cord-298169-2133gahl 138 7 bipolar bipolar JJ cord-298169-2133gahl 138 8 disorder disorder NN cord-298169-2133gahl 138 9 , , , cord-298169-2133gahl 138 10 the the DT cord-298169-2133gahl 138 11 protection protection NN cord-298169-2133gahl 138 12 conferred confer VBN cord-298169-2133gahl 138 13 by by IN cord-298169-2133gahl 138 14 low low JJ cord-298169-2133gahl 138 15 grade grade NN cord-298169-2133gahl 138 16 immunomodulation immunomodulation NN cord-298169-2133gahl 138 17 may may MD cord-298169-2133gahl 138 18 favor favor VB cord-298169-2133gahl 138 19 a a DT cord-298169-2133gahl 138 20 more more RBR cord-298169-2133gahl 138 21 efficient efficient JJ cord-298169-2133gahl 138 22 and and CC cord-298169-2133gahl 138 23 intense intense JJ cord-298169-2133gahl 138 24 pro pro JJ cord-298169-2133gahl 138 25 - - JJ cord-298169-2133gahl 138 26 inflammatory inflammatory JJ cord-298169-2133gahl 138 27 , , , cord-298169-2133gahl 138 28 anti anti JJ cord-298169-2133gahl 138 29 - - JJ cord-298169-2133gahl 138 30 infectious infectious JJ cord-298169-2133gahl 138 31 response response NN cord-298169-2133gahl 138 32 , , , cord-298169-2133gahl 138 33 but but CC cord-298169-2133gahl 138 34 outside outside IN cord-298169-2133gahl 138 35 the the DT cord-298169-2133gahl 138 36 neurodevelopmental neurodevelopmental JJ cord-298169-2133gahl 138 37 window window NN cord-298169-2133gahl 138 38 . . . cord-298169-2133gahl 139 1 At at IN cord-298169-2133gahl 139 2 the the DT cord-298169-2133gahl 139 3 time time NN cord-298169-2133gahl 139 4 of of IN cord-298169-2133gahl 139 5 writing write VBG cord-298169-2133gahl 139 6 this this DT cord-298169-2133gahl 139 7 review review NN cord-298169-2133gahl 139 8 , , , cord-298169-2133gahl 139 9 the the DT cord-298169-2133gahl 139 10 Covid-19 covid-19 JJ cord-298169-2133gahl 139 11 pandemic pandemic NN cord-298169-2133gahl 139 12 was be VBD cord-298169-2133gahl 139 13 devastating devastate VBG cord-298169-2133gahl 139 14 the the DT cord-298169-2133gahl 139 15 health health NN cord-298169-2133gahl 139 16 and and CC cord-298169-2133gahl 139 17 economies economy NNS cord-298169-2133gahl 139 18 of of IN cord-298169-2133gahl 139 19 countries country NNS cord-298169-2133gahl 139 20 worldwide worldwide RB cord-298169-2133gahl 139 21 , , , cord-298169-2133gahl 139 22 highlighting highlight VBG cord-298169-2133gahl 139 23 the the DT cord-298169-2133gahl 139 24 powerful powerful JJ cord-298169-2133gahl 139 25 influence influence NN cord-298169-2133gahl 139 26 that that WDT cord-298169-2133gahl 139 27 viruses virus NNS cord-298169-2133gahl 139 28 have have VBP cord-298169-2133gahl 139 29 had have VBN cord-298169-2133gahl 139 30 and and CC cord-298169-2133gahl 139 31 have have VB cord-298169-2133gahl 139 32 on on IN cord-298169-2133gahl 139 33 animal animal NN cord-298169-2133gahl 139 34 and and CC cord-298169-2133gahl 139 35 plant plant NN cord-298169-2133gahl 139 36 life life NN cord-298169-2133gahl 139 37 over over IN cord-298169-2133gahl 139 38 the the DT cord-298169-2133gahl 139 39 course course NN cord-298169-2133gahl 139 40 of of IN cord-298169-2133gahl 139 41 evolution evolution NN cord-298169-2133gahl 139 42 . . . cord-298169-2133gahl 140 1 There there EX cord-298169-2133gahl 140 2 is be VBZ cord-298169-2133gahl 140 3 an an DT cord-298169-2133gahl 140 4 increasing increase VBG cord-298169-2133gahl 140 5 appreciation appreciation NN cord-298169-2133gahl 140 6 of of IN cord-298169-2133gahl 140 7 the the DT cord-298169-2133gahl 140 8 role role NN cord-298169-2133gahl 140 9 of of IN cord-298169-2133gahl 140 10 viruses virus NNS cord-298169-2133gahl 140 11 in in IN cord-298169-2133gahl 140 12 wide wide JJ cord-298169-2133gahl 140 13 array array NN cord-298169-2133gahl 140 14 of of IN cord-298169-2133gahl 140 15 diverse diverse JJ cord-298169-2133gahl 140 16 medical medical JJ cord-298169-2133gahl 140 17 conditions condition NNS cord-298169-2133gahl 140 18 , , , cord-298169-2133gahl 140 19 including include VBG cord-298169-2133gahl 140 20 cancers cancer NNS cord-298169-2133gahl 140 21 and and CC cord-298169-2133gahl 140 22 neurodegenerative neurodegenerative JJ cord-298169-2133gahl 140 23 conditions condition NNS cord-298169-2133gahl 140 24 , , , cord-298169-2133gahl 140 25 but but CC cord-298169-2133gahl 140 26 also also RB cord-298169-2133gahl 140 27 in in IN cord-298169-2133gahl 140 28 psychiatric psychiatric JJ cord-298169-2133gahl 140 29 conditions condition NNS cord-298169-2133gahl 140 30 ( ( -LRB- cord-298169-2133gahl 140 31 Avramopoulos Avramopoulos NNP cord-298169-2133gahl 140 32 et et NNP cord-298169-2133gahl 140 33 al al NNP cord-298169-2133gahl 140 34 , , , cord-298169-2133gahl 140 35 2015 2015 CD cord-298169-2133gahl 140 36 ) ) -RRB- cord-298169-2133gahl 140 37 . . . cord-298169-2133gahl 141 1 Direct direct JJ cord-298169-2133gahl 141 2 impact impact NN cord-298169-2133gahl 141 3 of of IN cord-298169-2133gahl 141 4 viruses virus NNS cord-298169-2133gahl 141 5 on on IN cord-298169-2133gahl 141 6 the the DT cord-298169-2133gahl 141 7 central central JJ cord-298169-2133gahl 141 8 nervous nervous JJ cord-298169-2133gahl 141 9 system system NN cord-298169-2133gahl 141 10 was be VBD cord-298169-2133gahl 141 11 illustrated illustrate VBN cord-298169-2133gahl 141 12 in in IN cord-298169-2133gahl 141 13 contemporary contemporary JJ cord-298169-2133gahl 141 14 history history NN cord-298169-2133gahl 141 15 by by IN cord-298169-2133gahl 141 16 clinical clinical JJ cord-298169-2133gahl 141 17 situations situation NNS cord-298169-2133gahl 141 18 in in IN cord-298169-2133gahl 141 19 neuro neuro JJ cord-298169-2133gahl 141 20 - - HYPH cord-298169-2133gahl 141 21 psychiatric psychiatric JJ cord-298169-2133gahl 141 22 settings setting NNS cord-298169-2133gahl 141 23 after after IN cord-298169-2133gahl 141 24 pandemics pandemic NNS cord-298169-2133gahl 141 25 such such JJ cord-298169-2133gahl 141 26 as as IN cord-298169-2133gahl 141 27 the the DT cord-298169-2133gahl 141 28 Spanish spanish JJ cord-298169-2133gahl 141 29 flu flu NN cord-298169-2133gahl 141 30 or or CC cord-298169-2133gahl 141 31 the the DT cord-298169-2133gahl 141 32 more more RBR cord-298169-2133gahl 141 33 recent recent JJ cord-298169-2133gahl 141 34 H1N1 H1N1 NNP cord-298169-2133gahl 141 35 . . . cord-298169-2133gahl 142 1 While while IN cord-298169-2133gahl 142 2 an an DT cord-298169-2133gahl 142 3 increased increase VBN cord-298169-2133gahl 142 4 frequency frequency NN cord-298169-2133gahl 142 5 of of IN cord-298169-2133gahl 142 6 psychosis psychosis NN cord-298169-2133gahl 142 7 ( ( -LRB- cord-298169-2133gahl 142 8 Yudofsky Yudofsky NNP cord-298169-2133gahl 142 9 SC SC NNP cord-298169-2133gahl 142 10 , , , cord-298169-2133gahl 142 11 2009 2009 CD cord-298169-2133gahl 142 12 ) ) -RRB- cord-298169-2133gahl 142 13 and and CC cord-298169-2133gahl 142 14 encephalitis encephalitis RB cord-298169-2133gahl 142 15 lethargica lethargica NNP cord-298169-2133gahl 142 16 / / SYM cord-298169-2133gahl 142 17 parkinsonism parkinsonism NN cord-298169-2133gahl 143 1 ( ( -LRB- cord-298169-2133gahl 143 2 Lymphaibool Lymphaibool NNP cord-298169-2133gahl 143 3 et et NNP cord-298169-2133gahl 143 4 al al NNP cord-298169-2133gahl 143 5 , , , cord-298169-2133gahl 143 6 2019 2019 CD cord-298169-2133gahl 143 7 ; ; . cord-298169-2133gahl 144 1 Hoffman Hoffman NNP cord-298169-2133gahl 144 2 & & CC cord-298169-2133gahl 144 3 Vilensky Vilensky NNP cord-298169-2133gahl 144 4 , , , cord-298169-2133gahl 144 5 2017 2017 CD cord-298169-2133gahl 144 6 ) ) -RRB- cord-298169-2133gahl 144 7 were be VBD cord-298169-2133gahl 144 8 observed observe VBN cord-298169-2133gahl 144 9 following follow VBG cord-298169-2133gahl 144 10 the the DT cord-298169-2133gahl 144 11 Spanish spanish JJ cord-298169-2133gahl 144 12 flu flu NN cord-298169-2133gahl 144 13 pandemic pandemic NN cord-298169-2133gahl 144 14 , , , cord-298169-2133gahl 144 15 a a DT cord-298169-2133gahl 144 16 raised raise VBN cord-298169-2133gahl 144 17 rate rate NN cord-298169-2133gahl 144 18 of of IN cord-298169-2133gahl 144 19 narcolepsy narcolepsy NN cord-298169-2133gahl 144 20 was be VBD cord-298169-2133gahl 144 21 described describe VBN cord-298169-2133gahl 144 22 after after IN cord-298169-2133gahl 144 23 H1N1 H1N1 NNP cord-298169-2133gahl 144 24 pandemic pandemic NN cord-298169-2133gahl 144 25 likely likely RB cord-298169-2133gahl 144 26 triggered trigger VBN cord-298169-2133gahl 144 27 by by IN cord-298169-2133gahl 144 28 the the DT cord-298169-2133gahl 144 29 Pandemrix Pandemrix NNP cord-298169-2133gahl 145 1 ® ® NNP cord-298169-2133gahl 145 2 vaccination vaccination NN cord-298169-2133gahl 146 1 ( ( -LRB- cord-298169-2133gahl 146 2 Sarkanen Sarkanen NNP cord-298169-2133gahl 146 3 et et FW cord-298169-2133gahl 146 4 al al NNP cord-298169-2133gahl 146 5 , , , cord-298169-2133gahl 146 6 2018 2018 CD cord-298169-2133gahl 146 7 ) ) -RRB- cord-298169-2133gahl 146 8 . . . cord-298169-2133gahl 147 1 More more RBR cord-298169-2133gahl 147 2 recently recently RB cord-298169-2133gahl 147 3 , , , cord-298169-2133gahl 147 4 comforting comfort VBG cord-298169-2133gahl 147 5 early early RB cord-298169-2133gahl 147 6 reported report VBD cord-298169-2133gahl 147 7 deleterious deleterious JJ cord-298169-2133gahl 147 8 effects effect NNS cord-298169-2133gahl 147 9 of of IN cord-298169-2133gahl 147 10 viral viral JJ cord-298169-2133gahl 147 11 infections infection NNS cord-298169-2133gahl 147 12 on on IN cord-298169-2133gahl 147 13 CNS CNS NNP cord-298169-2133gahl 147 14 , , , cord-298169-2133gahl 147 15 large large JJ cord-298169-2133gahl 147 16 nationwide nationwide JJ cord-298169-2133gahl 147 17 studies study NNS cord-298169-2133gahl 147 18 demonstrated demonstrate VBD cord-298169-2133gahl 147 19 association association NN cord-298169-2133gahl 147 20 between between IN cord-298169-2133gahl 147 21 maternal maternal JJ cord-298169-2133gahl 147 22 viral viral JJ cord-298169-2133gahl 147 23 infectious infectious JJ cord-298169-2133gahl 147 24 events event NNS cord-298169-2133gahl 147 25 during during IN cord-298169-2133gahl 147 26 the the DT cord-298169-2133gahl 147 27 first first JJ cord-298169-2133gahl 147 28 trimester trimester NN cord-298169-2133gahl 147 29 and and CC cord-298169-2133gahl 147 30 subsequent subsequent JJ cord-298169-2133gahl 147 31 psychiatric psychiatric JJ cord-298169-2133gahl 147 32 diseases disease NNS cord-298169-2133gahl 147 33 in in IN cord-298169-2133gahl 147 34 the the DT cord-298169-2133gahl 147 35 offspring offspring NN cord-298169-2133gahl 147 36 ( ( -LRB- cord-298169-2133gahl 147 37 Brown Brown NNP cord-298169-2133gahl 147 38 & & CC cord-298169-2133gahl 147 39 Derkits Derkits NNP cord-298169-2133gahl 147 40 , , , cord-298169-2133gahl 147 41 2009 2009 CD cord-298169-2133gahl 147 42 ) ) -RRB- cord-298169-2133gahl 147 43 . . . cord-298169-2133gahl 148 1 It -PRON- PRP cord-298169-2133gahl 148 2 is be VBZ cord-298169-2133gahl 148 3 worth worth JJ cord-298169-2133gahl 148 4 reminding remind VBG cord-298169-2133gahl 148 5 here here RB cord-298169-2133gahl 148 6 again again RB cord-298169-2133gahl 148 7 , , , cord-298169-2133gahl 148 8 as as IN cord-298169-2133gahl 148 9 for for IN cord-298169-2133gahl 148 10 the the DT cord-298169-2133gahl 148 11 vast vast JJ cord-298169-2133gahl 148 12 majority majority NN cord-298169-2133gahl 148 13 of of IN cord-298169-2133gahl 148 14 viral viral JJ cord-298169-2133gahl 148 15 infections infection NNS cord-298169-2133gahl 148 16 , , , cord-298169-2133gahl 148 17 that that IN cord-298169-2133gahl 148 18 the the DT cord-298169-2133gahl 148 19 HLA HLA NNP cord-298169-2133gahl 148 20 system system NN cord-298169-2133gahl 148 21 is be VBZ cord-298169-2133gahl 148 22 pivotal pivotal JJ cord-298169-2133gahl 148 23 in in IN cord-298169-2133gahl 148 24 the the DT cord-298169-2133gahl 148 25 anti anti JJ cord-298169-2133gahl 148 26 - - JJ cord-298169-2133gahl 148 27 infectious infectious JJ cord-298169-2133gahl 148 28 immune immune JJ cord-298169-2133gahl 148 29 response response NN cord-298169-2133gahl 148 30 processes process NNS cord-298169-2133gahl 148 31 , , , cord-298169-2133gahl 148 32 very very RB cord-298169-2133gahl 148 33 likely likely JJ cord-298169-2133gahl 148 34 in in IN cord-298169-2133gahl 148 35 the the DT cord-298169-2133gahl 148 36 present present JJ cord-298169-2133gahl 148 37 pandemics pandemic NNS cord-298169-2133gahl 148 38 too too RB cord-298169-2133gahl 148 39 . . . cord-298169-2133gahl 149 1 In in IN cord-298169-2133gahl 149 2 the the DT cord-298169-2133gahl 149 3 current current JJ cord-298169-2133gahl 149 4 context context NN cord-298169-2133gahl 149 5 , , , cord-298169-2133gahl 149 6 it -PRON- PRP cord-298169-2133gahl 149 7 is be VBZ cord-298169-2133gahl 149 8 important important JJ cord-298169-2133gahl 149 9 to to TO cord-298169-2133gahl 149 10 note note VB cord-298169-2133gahl 149 11 that that IN cord-298169-2133gahl 149 12 variations variation NNS cord-298169-2133gahl 149 13 in in IN cord-298169-2133gahl 149 14 HLA HLA NNP cord-298169-2133gahl 149 15 / / SYM cord-298169-2133gahl 149 16 MHC MHC NNP cord-298169-2133gahl 149 17 act act VBP cord-298169-2133gahl 149 18 to to TO cord-298169-2133gahl 149 19 regulate regulate VB cord-298169-2133gahl 149 20 viral viral JJ cord-298169-2133gahl 149 21 infections infection NNS cord-298169-2133gahl 149 22 , , , cord-298169-2133gahl 149 23 including include VBG cord-298169-2133gahl 149 24 influenza influenza NN cord-298169-2133gahl 149 25 infection infection NN cord-298169-2133gahl 149 26 in in IN cord-298169-2133gahl 149 27 humans human NNS cord-298169-2133gahl 149 28 ( ( -LRB- cord-298169-2133gahl 149 29 Dutta Dutta NNP cord-298169-2133gahl 149 30 et et NNP cord-298169-2133gahl 149 31 al al NNP cord-298169-2133gahl 149 32 , , , cord-298169-2133gahl 149 33 2018 2018 CD cord-298169-2133gahl 149 34 ) ) -RRB- cord-298169-2133gahl 149 35 . . . cord-298169-2133gahl 150 1 Influenza influenza NN cord-298169-2133gahl 150 2 and and CC cord-298169-2133gahl 150 3 other other JJ cord-298169-2133gahl 150 4 infections infection NNS cord-298169-2133gahl 150 5 prenatally prenatally RB cord-298169-2133gahl 150 6 can can MD cord-298169-2133gahl 150 7 also also RB cord-298169-2133gahl 150 8 increase increase VB cord-298169-2133gahl 150 9 risk risk NN cord-298169-2133gahl 150 10 of of IN cord-298169-2133gahl 150 11 schizophrenia schizophrenia NN cord-298169-2133gahl 150 12 and and CC cord-298169-2133gahl 150 13 autism autism NN cord-298169-2133gahl 150 14 spectrum spectrum NN cord-298169-2133gahl 150 15 disorders disorder NNS cord-298169-2133gahl 150 16 in in IN cord-298169-2133gahl 150 17 the the DT cord-298169-2133gahl 150 18 offspring offspring NN cord-298169-2133gahl 150 19 , , , cord-298169-2133gahl 150 20 suggesting suggest VBG cord-298169-2133gahl 150 21 that that IN cord-298169-2133gahl 150 22 HLA HLA NNP cord-298169-2133gahl 150 23 / / SYM cord-298169-2133gahl 150 24 MHC MHC NNP cord-298169-2133gahl 150 25 genetic genetic JJ cord-298169-2133gahl 150 26 variations variation NNS cord-298169-2133gahl 150 27 may may MD cord-298169-2133gahl 150 28 interact interact VB cord-298169-2133gahl 150 29 with with IN cord-298169-2133gahl 150 30 prenatal prenatal JJ cord-298169-2133gahl 150 31 infection infection NN cord-298169-2133gahl 150 32 in in IN cord-298169-2133gahl 150 33 the the DT cord-298169-2133gahl 150 34 etiology etiology NN cord-298169-2133gahl 150 35 of of IN cord-298169-2133gahl 150 36 major major JJ cord-298169-2133gahl 150 37 psychiatric psychiatric JJ cord-298169-2133gahl 150 38 disorders disorder NNS cord-298169-2133gahl 150 39 , , , cord-298169-2133gahl 150 40 although although IN cord-298169-2133gahl 150 41 complicated complicate VBN cord-298169-2133gahl 150 42 by by IN cord-298169-2133gahl 150 43 the the DT cord-298169-2133gahl 150 44 immune immune JJ cord-298169-2133gahl 150 45 - - HYPH cord-298169-2133gahl 150 46 suppression suppression NN cord-298169-2133gahl 150 47 that that WDT cord-298169-2133gahl 150 48 occurs occur VBZ cord-298169-2133gahl 150 49 in in IN cord-298169-2133gahl 150 50 pregnancy pregnancy NN cord-298169-2133gahl 151 1 ( ( -LRB- cord-298169-2133gahl 151 2 Shah Shah NNP cord-298169-2133gahl 151 3 et et NNP cord-298169-2133gahl 151 4 al al NNP cord-298169-2133gahl 151 5 , , , cord-298169-2133gahl 151 6 2010 2010 CD cord-298169-2133gahl 151 7 ) ) -RRB- cord-298169-2133gahl 151 8 . . . cord-298169-2133gahl 152 1 The the DT cord-298169-2133gahl 152 2 devastating devastating JJ cord-298169-2133gahl 152 3 influence influence NN cord-298169-2133gahl 152 4 of of IN cord-298169-2133gahl 152 5 the the DT cord-298169-2133gahl 152 6 severe severe JJ cord-298169-2133gahl 152 7 acute acute JJ cord-298169-2133gahl 152 8 respiratory respiratory JJ cord-298169-2133gahl 152 9 syndrome syndrome NN cord-298169-2133gahl 152 10 coronavirus coronavirus NN cord-298169-2133gahl 152 11 ( ( -LRB- cord-298169-2133gahl 152 12 SARS SARS NNP cord-298169-2133gahl 152 13 - - HYPH cord-298169-2133gahl 152 14 CoV)-2 CoV)-2 NNP cord-298169-2133gahl 152 15 virus virus NN cord-298169-2133gahl 152 16 that that WDT cord-298169-2133gahl 152 17 has have VBZ cord-298169-2133gahl 152 18 led lead VBN cord-298169-2133gahl 152 19 to to IN cord-298169-2133gahl 152 20 the the DT cord-298169-2133gahl 152 21 Covid-19 covid-19 JJ cord-298169-2133gahl 152 22 pandemic pandemic NN cord-298169-2133gahl 152 23 raises raise VBZ cord-298169-2133gahl 152 24 the the DT cord-298169-2133gahl 152 25 question question NN cord-298169-2133gahl 152 26 as as IN cord-298169-2133gahl 152 27 to to IN cord-298169-2133gahl 152 28 the the DT cord-298169-2133gahl 152 29 role role NN cord-298169-2133gahl 152 30 of of IN cord-298169-2133gahl 152 31 HLA HLA NNP cord-298169-2133gahl 152 32 / / SYM cord-298169-2133gahl 152 33 MHC MHC NNP cord-298169-2133gahl 152 34 in in IN cord-298169-2133gahl 152 35 the the DT cord-298169-2133gahl 152 36 regulation regulation NN cord-298169-2133gahl 152 37 of of IN cord-298169-2133gahl 152 38 the the DT cord-298169-2133gahl 152 39 inflammatory inflammatory JJ cord-298169-2133gahl 152 40 processes process NNS cord-298169-2133gahl 152 41 which which WDT cord-298169-2133gahl 152 42 is be VBZ cord-298169-2133gahl 152 43 an an DT cord-298169-2133gahl 152 44 integral integral JJ cord-298169-2133gahl 152 45 aspect aspect NN cord-298169-2133gahl 152 46 of of IN cord-298169-2133gahl 152 47 SARS SARS NNP cord-298169-2133gahl 152 48 - - HYPH cord-298169-2133gahl 152 49 CoV-2 CoV-2 NNP cord-298169-2133gahl 152 50 infection infection NN cord-298169-2133gahl 152 51 , , , cord-298169-2133gahl 152 52 usually usually RB cord-298169-2133gahl 152 53 referred refer VBD cord-298169-2133gahl 152 54 to to IN cord-298169-2133gahl 152 55 as as IN cord-298169-2133gahl 152 56 the the DT cord-298169-2133gahl 152 57 ' ' `` cord-298169-2133gahl 152 58 cytokine cytokine NN cord-298169-2133gahl 152 59 storm storm NN cord-298169-2133gahl 152 60 ' ' '' cord-298169-2133gahl 152 61 . . . cord-298169-2133gahl 153 1 This this DT cord-298169-2133gahl 153 2 will will MD cord-298169-2133gahl 153 3 also also RB cord-298169-2133gahl 153 4 be be VB cord-298169-2133gahl 153 5 important important JJ cord-298169-2133gahl 153 6 to to TO cord-298169-2133gahl 153 7 investigate investigate VB cord-298169-2133gahl 153 8 in in IN cord-298169-2133gahl 153 9 the the DT cord-298169-2133gahl 153 10 distinct distinct JJ cord-298169-2133gahl 153 11 sub sub NN cord-298169-2133gahl 153 12 - - NNS cord-298169-2133gahl 153 13 groups group NNS cord-298169-2133gahl 153 14 of of IN cord-298169-2133gahl 153 15 major major JJ cord-298169-2133gahl 153 16 psychiatric psychiatric JJ cord-298169-2133gahl 153 17 disorder disorder NN cord-298169-2133gahl 153 18 patients patient NNS cord-298169-2133gahl 153 19 carrying carry VBG cord-298169-2133gahl 153 20 particular particular JJ cord-298169-2133gahl 153 21 variations variation NNS cord-298169-2133gahl 153 22 of of IN cord-298169-2133gahl 153 23 their -PRON- PRP$ cord-298169-2133gahl 153 24 HLA HLA NNP cord-298169-2133gahl 153 25 alleles allele NNS cord-298169-2133gahl 153 26 . . . cord-298169-2133gahl 154 1 Although although IN cord-298169-2133gahl 154 2 the the DT cord-298169-2133gahl 154 3 literature literature NN cord-298169-2133gahl 154 4 concerning concern VBG cord-298169-2133gahl 154 5 the the DT cord-298169-2133gahl 154 6 immunogenetic immunogenetic JJ cord-298169-2133gahl 154 7 aspects aspect NNS cord-298169-2133gahl 154 8 of of IN cord-298169-2133gahl 154 9 previous previous JJ cord-298169-2133gahl 154 10 pandemic pandemic NN cord-298169-2133gahl 154 11 waves wave NNS cord-298169-2133gahl 154 12 of of IN cord-298169-2133gahl 154 13 SARS SARS NNP cord-298169-2133gahl 154 14 or or CC cord-298169-2133gahl 154 15 MERS MERS NNP cord-298169-2133gahl 154 16 - - HYPH cord-298169-2133gahl 154 17 Cov Cov NNP cord-298169-2133gahl 154 18 ( ( -LRB- cord-298169-2133gahl 154 19 middle middle NNP cord-298169-2133gahl 154 20 east east NNP cord-298169-2133gahl 154 21 respiratory respiratory JJ cord-298169-2133gahl 154 22 syndrome syndrome NN cord-298169-2133gahl 154 23 ) ) -RRB- cord-298169-2133gahl 154 24 is be VBZ cord-298169-2133gahl 154 25 relatively relatively RB cord-298169-2133gahl 154 26 low low JJ cord-298169-2133gahl 154 27 , , , cord-298169-2133gahl 154 28 data datum NNS cord-298169-2133gahl 154 29 do do VBP cord-298169-2133gahl 154 30 show show VB cord-298169-2133gahl 154 31 that that IN cord-298169-2133gahl 154 32 HLA HLA NNP cord-298169-2133gahl 154 33 plays play VBZ cord-298169-2133gahl 154 34 a a DT cord-298169-2133gahl 154 35 major major JJ cord-298169-2133gahl 154 36 role role NN cord-298169-2133gahl 154 37 in in IN cord-298169-2133gahl 154 38 viral viral JJ cord-298169-2133gahl 154 39 infection infection NN cord-298169-2133gahl 154 40 regulation regulation NN cord-298169-2133gahl 154 41 , , , cord-298169-2133gahl 154 42 and and CC cord-298169-2133gahl 154 43 this this DT cord-298169-2133gahl 154 44 is be VBZ cord-298169-2133gahl 154 45 also also RB cord-298169-2133gahl 154 46 relevant relevant JJ cord-298169-2133gahl 154 47 to to TO cord-298169-2133gahl 154 48 analyze analyze VB cord-298169-2133gahl 154 49 risk risk NN cord-298169-2133gahl 154 50 / / SYM cord-298169-2133gahl 154 51 protection protection NN cord-298169-2133gahl 154 52 of of IN cord-298169-2133gahl 154 53 major major JJ cord-298169-2133gahl 154 54 psychiatric psychiatric JJ cord-298169-2133gahl 154 55 disorders disorder NNS cord-298169-2133gahl 154 56 in in IN cord-298169-2133gahl 154 57 the the DT cord-298169-2133gahl 154 58 pandemic pandemic NN cord-298169-2133gahl 154 59 context context NN cord-298169-2133gahl 154 60 . . . cord-298169-2133gahl 155 1 The the DT cord-298169-2133gahl 155 2 available available JJ cord-298169-2133gahl 155 3 data datum NNS cord-298169-2133gahl 155 4 on on IN cord-298169-2133gahl 155 5 HLA HLA NNP cord-298169-2133gahl 155 6 diversity diversity NN cord-298169-2133gahl 155 7 show show NN cord-298169-2133gahl 155 8 associations association NNS cord-298169-2133gahl 155 9 with with IN cord-298169-2133gahl 155 10 HLA HLA NNP cord-298169-2133gahl 155 11 - - HYPH cord-298169-2133gahl 155 12 class class NN cord-298169-2133gahl 155 13 II II NNP cord-298169-2133gahl 155 14 alleles allele NNS cord-298169-2133gahl 155 15 , , , cord-298169-2133gahl 155 16 notably notably RB cord-298169-2133gahl 155 17 the the DT cord-298169-2133gahl 155 18 HLA HLA NNP cord-298169-2133gahl 155 19 - - HYPH cord-298169-2133gahl 155 20 DRB1 DRB1 NNP cord-298169-2133gahl 155 21 * * NFP cord-298169-2133gahl 155 22 03 03 CD cord-298169-2133gahl 155 23 variant variant NN cord-298169-2133gahl 155 24 in in IN cord-298169-2133gahl 155 25 two two CD cord-298169-2133gahl 155 26 studies study NNS cord-298169-2133gahl 155 27 from from IN cord-298169-2133gahl 155 28 Taiwan Taiwan NNP cord-298169-2133gahl 156 1 ( ( -LRB- cord-298169-2133gahl 156 2 Wang Wang NNP cord-298169-2133gahl 156 3 et et NNP cord-298169-2133gahl 156 4 al al NNP cord-298169-2133gahl 156 5 , , , cord-298169-2133gahl 156 6 2011 2011 CD cord-298169-2133gahl 156 7 ) ) -RRB- cord-298169-2133gahl 156 8 , , , cord-298169-2133gahl 156 9 and and CC cord-298169-2133gahl 156 10 Hong Hong NNP cord-298169-2133gahl 156 11 Kong Kong NNP cord-298169-2133gahl 157 1 ( ( -LRB- cord-298169-2133gahl 157 2 Ng Ng NNP cord-298169-2133gahl 157 3 et et FW cord-298169-2133gahl 157 4 al al NNP cord-298169-2133gahl 157 5 , , , cord-298169-2133gahl 157 6 2004 2004 CD cord-298169-2133gahl 158 1 ( ( -LRB- cord-298169-2133gahl 158 2 Nguyen Nguyen NNP cord-298169-2133gahl 158 3 et et NNP cord-298169-2133gahl 158 4 al al NNP cord-298169-2133gahl 158 5 , , , cord-298169-2133gahl 158 6 2020 2020 CD cord-298169-2133gahl 158 7 ) ) -RRB- cord-298169-2133gahl 158 8 . . . cord-298169-2133gahl 159 1 As as IN cord-298169-2133gahl 159 2 acknowledged acknowledge VBN cord-298169-2133gahl 159 3 by by IN cord-298169-2133gahl 159 4 the the DT cord-298169-2133gahl 159 5 authors author NNS cord-298169-2133gahl 159 6 , , , cord-298169-2133gahl 159 7 among among IN cord-298169-2133gahl 159 8 many many JJ cord-298169-2133gahl 159 9 other other JJ cord-298169-2133gahl 159 10 limitations limitation NNS cord-298169-2133gahl 159 11 , , , cord-298169-2133gahl 159 12 peptide peptide NN cord-298169-2133gahl 159 13 - - HYPH cord-298169-2133gahl 159 14 MHC MHC NNP cord-298169-2133gahl 159 15 binding bind VBG cord-298169-2133gahl 159 16 affinity affinity NN cord-298169-2133gahl 159 17 can can MD cord-298169-2133gahl 159 18 not not RB cord-298169-2133gahl 159 19 be be VB cord-298169-2133gahl 159 20 alone alone RB cord-298169-2133gahl 159 21 a a DT cord-298169-2133gahl 159 22 predictor predictor NN cord-298169-2133gahl 159 23 of of IN cord-298169-2133gahl 159 24 subsequent subsequent JJ cord-298169-2133gahl 159 25 T t NN cord-298169-2133gahl 159 26 - - HYPH cord-298169-2133gahl 159 27 cell cell NN cord-298169-2133gahl 159 28 responses response NNS cord-298169-2133gahl 159 29 . . . cord-298169-2133gahl 160 1 The the DT cord-298169-2133gahl 160 2 psychiatric psychiatric JJ cord-298169-2133gahl 160 3 inpatient inpatient JJ cord-298169-2133gahl 160 4 population population NN cord-298169-2133gahl 160 5 - - HYPH cord-298169-2133gahl 160 6 group group NN cord-298169-2133gahl 160 7 is be VBZ cord-298169-2133gahl 160 8 at at IN cord-298169-2133gahl 160 9 high high JJ cord-298169-2133gahl 160 10 risk risk NN cord-298169-2133gahl 160 11 for for IN cord-298169-2133gahl 160 12 any any DT cord-298169-2133gahl 160 13 epidemic epidemic NN cord-298169-2133gahl 160 14 threat threat NN cord-298169-2133gahl 160 15 . . . cord-298169-2133gahl 161 1 Increased increase VBN cord-298169-2133gahl 161 2 vulnerability vulnerability NN cord-298169-2133gahl 161 3 not not RB cord-298169-2133gahl 161 4 only only RB cord-298169-2133gahl 161 5 arises arise VBZ cord-298169-2133gahl 161 6 due due JJ cord-298169-2133gahl 161 7 their -PRON- PRP$ cord-298169-2133gahl 161 8 psychiatric psychiatric JJ cord-298169-2133gahl 161 9 condition condition NN cord-298169-2133gahl 161 10 , , , cord-298169-2133gahl 161 11 associated associated JJ cord-298169-2133gahl 161 12 stressors stressor NNS cord-298169-2133gahl 161 13 , , , cord-298169-2133gahl 161 14 and and CC cord-298169-2133gahl 161 15 confinement confinement NN cord-298169-2133gahl 161 16 with with IN cord-298169-2133gahl 161 17 other other JJ cord-298169-2133gahl 161 18 patients patient NNS cord-298169-2133gahl 161 19 but but CC cord-298169-2133gahl 161 20 also also RB cord-298169-2133gahl 161 21 from from IN cord-298169-2133gahl 161 22 their -PRON- PRP$ cord-298169-2133gahl 161 23 comorbid comorbid JJ cord-298169-2133gahl 161 24 somatic somatic JJ cord-298169-2133gahl 161 25 disorders disorder NNS cord-298169-2133gahl 161 26 including include VBG cord-298169-2133gahl 161 27 , , , cord-298169-2133gahl 161 28 cardiovascular cardiovascular JJ cord-298169-2133gahl 161 29 disorders disorder NNS cord-298169-2133gahl 161 30 , , , cord-298169-2133gahl 161 31 metabolic metabolic JJ cord-298169-2133gahl 161 32 syndrome syndrome NN cord-298169-2133gahl 161 33 , , , cord-298169-2133gahl 161 34 diabetes diabetes NN cord-298169-2133gahl 161 35 , , , cord-298169-2133gahl 161 36 autoimmune autoimmune JJ cord-298169-2133gahl 161 37 disorders disorder NNS cord-298169-2133gahl 161 38 and and CC cord-298169-2133gahl 161 39 respiratory respiratory JJ cord-298169-2133gahl 161 40 tract tract NN cord-298169-2133gahl 161 41 dysfunctions dysfunction NNS cord-298169-2133gahl 161 42 . . . cord-298169-2133gahl 162 1 All all DT cord-298169-2133gahl 162 2 of of IN cord-298169-2133gahl 162 3 these these DT cord-298169-2133gahl 162 4 common common JJ cord-298169-2133gahl 162 5 comorbidities comorbiditie NNS cord-298169-2133gahl 162 6 are be VBP cord-298169-2133gahl 162 7 risk risk NN cord-298169-2133gahl 162 8 factors factor NNS cord-298169-2133gahl 162 9 for for IN cord-298169-2133gahl 162 10 severe severe JJ cord-298169-2133gahl 162 11 infection infection NN cord-298169-2133gahl 162 12 and and CC cord-298169-2133gahl 162 13 almost almost RB cord-298169-2133gahl 162 14 all all DT cord-298169-2133gahl 162 15 are be VBP cord-298169-2133gahl 162 16 linked link VBN cord-298169-2133gahl 162 17 to to IN cord-298169-2133gahl 162 18 HLA HLA NNP cord-298169-2133gahl 162 19 genetic genetic JJ cord-298169-2133gahl 162 20 diversity diversity NN cord-298169-2133gahl 162 21 ( ( -LRB- cord-298169-2133gahl 162 22 Trowsdale Trowsdale NNP cord-298169-2133gahl 162 23 and and CC cord-298169-2133gahl 162 24 Knight Knight NNP cord-298169-2133gahl 162 25 , , , cord-298169-2133gahl 162 26 2013 2013 CD cord-298169-2133gahl 162 27 ) ) -RRB- cord-298169-2133gahl 162 28 . . . cord-298169-2133gahl 163 1 As as IN cord-298169-2133gahl 163 2 with with IN cord-298169-2133gahl 163 3 influenza influenza NN cord-298169-2133gahl 163 4 viruses virus NNS cord-298169-2133gahl 163 5 , , , cord-298169-2133gahl 163 6 the the DT cord-298169-2133gahl 163 7 most most RBS cord-298169-2133gahl 163 8 deleterious deleterious JJ cord-298169-2133gahl 163 9 event event NN cord-298169-2133gahl 163 10 in in IN cord-298169-2133gahl 163 11 Covid-19 covid-19 NN cord-298169-2133gahl 163 12 does do VBZ cord-298169-2133gahl 163 13 not not RB cord-298169-2133gahl 163 14 seem seem VB cord-298169-2133gahl 163 15 to to TO cord-298169-2133gahl 163 16 be be VB cord-298169-2133gahl 163 17 the the DT cord-298169-2133gahl 163 18 infectious infectious JJ cord-298169-2133gahl 163 19 agent agent NN cord-298169-2133gahl 163 20 per per FW cord-298169-2133gahl 163 21 se se FW cord-298169-2133gahl 163 22 , , , cord-298169-2133gahl 163 23 but but CC cord-298169-2133gahl 163 24 the the DT cord-298169-2133gahl 163 25 overwhelmed overwhelmed JJ cord-298169-2133gahl 163 26 reactive reactive JJ cord-298169-2133gahl 163 27 inflammation inflammation NN cord-298169-2133gahl 163 28 arising arise VBG cord-298169-2133gahl 163 29 from from IN cord-298169-2133gahl 163 30 the the DT cord-298169-2133gahl 163 31 ' ' `` cord-298169-2133gahl 163 32 cytokine cytokine NN cord-298169-2133gahl 163 33 storm storm NN cord-298169-2133gahl 163 34 ' ' '' cord-298169-2133gahl 163 35 . . . cord-298169-2133gahl 164 1 Future future JJ cord-298169-2133gahl 164 2 research research NN cord-298169-2133gahl 164 3 will will MD cord-298169-2133gahl 164 4 have have VB cord-298169-2133gahl 164 5 to to TO cord-298169-2133gahl 164 6 determine determine VB cord-298169-2133gahl 164 7 whether whether IN cord-298169-2133gahl 164 8 variations variation NNS cord-298169-2133gahl 164 9 in in IN cord-298169-2133gahl 164 10 HLA HLA NNP cord-298169-2133gahl 164 11 genetic genetic JJ cord-298169-2133gahl 164 12 diversity diversity NN cord-298169-2133gahl 164 13 modulate modulate VBP cord-298169-2133gahl 164 14 the the DT cord-298169-2133gahl 164 15 susceptibility susceptibility NN cord-298169-2133gahl 164 16 to to IN cord-298169-2133gahl 164 17 severe severe JJ cord-298169-2133gahl 164 18 infection infection NN cord-298169-2133gahl 164 19 and and CC cord-298169-2133gahl 164 20 fatality fatality NN cord-298169-2133gahl 164 21 in in IN cord-298169-2133gahl 164 22 major major JJ cord-298169-2133gahl 164 23 psychiatric psychiatric JJ cord-298169-2133gahl 164 24 disorders disorder NNS cord-298169-2133gahl 164 25 subjected subject VBN cord-298169-2133gahl 164 26 to to IN cord-298169-2133gahl 164 27 the the DT cord-298169-2133gahl 164 28 SARS SARS NNP cord-298169-2133gahl 164 29 - - HYPH cord-298169-2133gahl 164 30 CoV-2 CoV-2 NNP cord-298169-2133gahl 164 31 pandemic pandemic NN cord-298169-2133gahl 164 32 . . . cord-298169-2133gahl 165 1 The the DT cord-298169-2133gahl 165 2 data datum NNS cord-298169-2133gahl 165 3 reviewed review VBN cord-298169-2133gahl 165 4 above above RB cord-298169-2133gahl 165 5 and and CC cord-298169-2133gahl 165 6 the the DT cord-298169-2133gahl 165 7 long long JJ cord-298169-2133gahl 165 8 evolutionary evolutionary JJ cord-298169-2133gahl 165 9 history history NN cord-298169-2133gahl 165 10 of of IN cord-298169-2133gahl 165 11 HLA HLA NNP cord-298169-2133gahl 165 12 - - HYPH cord-298169-2133gahl 165 13 equivalent equivalent JJ cord-298169-2133gahl 165 14 loci locus NNS cord-298169-2133gahl 165 15 , , , cord-298169-2133gahl 165 16 including include VBG cord-298169-2133gahl 165 17 further further JJ cord-298169-2133gahl 165 18 investigation investigation NN cord-298169-2133gahl 165 19 is be VBZ cord-298169-2133gahl 165 20 required require VBN cord-298169-2133gahl 165 21 in in IN cord-298169-2133gahl 165 22 people people NNS cord-298169-2133gahl 165 23 from from IN cord-298169-2133gahl 165 24 Africa Africa NNP cord-298169-2133gahl 165 25 , , , cord-298169-2133gahl 165 26 given give VBN cord-298169-2133gahl 165 27 that that IN cord-298169-2133gahl 165 28 the the DT cord-298169-2133gahl 165 29 rate rate NN cord-298169-2133gahl 165 30 of of IN cord-298169-2133gahl 165 31 the the DT cord-298169-2133gahl 165 32 genetic genetic JJ cord-298169-2133gahl 165 33 diversity diversity NN cord-298169-2133gahl 165 34 is be VBZ cord-298169-2133gahl 165 35 the the DT cord-298169-2133gahl 165 36 highest high JJS cord-298169-2133gahl 165 37 in in IN cord-298169-2133gahl 165 38 Africans Africans NNPS cord-298169-2133gahl 165 39 amongst amongst IN cord-298169-2133gahl 165 40 all all DT cord-298169-2133gahl 165 41 human human JJ cord-298169-2133gahl 165 42 ethnic ethnic JJ cord-298169-2133gahl 165 43 groups group NNS cord-298169-2133gahl 165 44 . . . cord-298169-2133gahl 166 1 In in IN cord-298169-2133gahl 166 2 this this DT cord-298169-2133gahl 166 3 context context NN cord-298169-2133gahl 166 4 , , , cord-298169-2133gahl 166 5 a a DT cord-298169-2133gahl 166 6 recent recent JJ cord-298169-2133gahl 166 7 study study NN cord-298169-2133gahl 166 8 of of IN cord-298169-2133gahl 166 9 a a DT cord-298169-2133gahl 166 10 sample sample NN cord-298169-2133gahl 166 11 of of IN cord-298169-2133gahl 166 12 SZ SZ NNP cord-298169-2133gahl 166 13 patients patient NNS cord-298169-2133gahl 166 14 from from IN cord-298169-2133gahl 166 15 south south NNP cord-298169-2133gahl 166 16 Africa Africa NNP cord-298169-2133gahl 166 17 , , , cord-298169-2133gahl 166 18 namely namely RB cord-298169-2133gahl 166 19 the the DT cord-298169-2133gahl 166 20 Xhosa xhosa JJ cord-298169-2133gahl 166 21 population population NN cord-298169-2133gahl 166 22 - - HYPH cord-298169-2133gahl 166 23 group group NN cord-298169-2133gahl 166 24 , , , cord-298169-2133gahl 166 25 revealed reveal VBD cord-298169-2133gahl 166 26 not not RB cord-298169-2133gahl 166 27 only only RB cord-298169-2133gahl 166 28 that that IN cord-298169-2133gahl 166 29 the the DT cord-298169-2133gahl 166 30 observed observed JJ cord-298169-2133gahl 166 31 overall overall JJ cord-298169-2133gahl 166 32 genetic genetic JJ cord-298169-2133gahl 166 33 diversity diversity NN cord-298169-2133gahl 166 34 was be VBD cord-298169-2133gahl 166 35 more more RBR cord-298169-2133gahl 166 36 important important JJ cord-298169-2133gahl 166 37 than than IN cord-298169-2133gahl 166 38 that that DT cord-298169-2133gahl 166 39 of of IN cord-298169-2133gahl 166 40 non non JJ cord-298169-2133gahl 166 41 - - JJ cord-298169-2133gahl 166 42 African african JJ cord-298169-2133gahl 166 43 populations population NNS cord-298169-2133gahl 166 44 , , , cord-298169-2133gahl 166 45 but but CC cord-298169-2133gahl 166 46 importantly importantly RB cord-298169-2133gahl 166 47 uncover uncover VBP cord-298169-2133gahl 166 48 mutational mutational JJ cord-298169-2133gahl 166 49 events event NNS cord-298169-2133gahl 166 50 relevant relevant JJ cord-298169-2133gahl 166 51 to to IN cord-298169-2133gahl 166 52 the the DT cord-298169-2133gahl 166 53 origins origin NNS cord-298169-2133gahl 166 54 of of IN cord-298169-2133gahl 166 55 schizophrenia schizophrenia NNP cord-298169-2133gahl 167 1 ( ( -LRB- cord-298169-2133gahl 167 2 Gulsuner Gulsuner NNP cord-298169-2133gahl 167 3 et et FW cord-298169-2133gahl 167 4 al al NNP cord-298169-2133gahl 167 5 , , , cord-298169-2133gahl 167 6 2020 2020 CD cord-298169-2133gahl 167 7 ) ) -RRB- cord-298169-2133gahl 167 8 . . . cord-298169-2133gahl 168 1 Future future JJ cord-298169-2133gahl 168 2 studies study NNS cord-298169-2133gahl 168 3 of of IN cord-298169-2133gahl 168 4 long long RB cord-298169-2133gahl 168 5 - - HYPH cord-298169-2133gahl 168 6 established establish VBN cord-298169-2133gahl 168 7 populations population NNS cord-298169-2133gahl 168 8 from from IN cord-298169-2133gahl 168 9 where where WRB cord-298169-2133gahl 168 10 the the DT cord-298169-2133gahl 168 11 human human JJ cord-298169-2133gahl 168 12 genome genome NN cord-298169-2133gahl 168 13 was be VBD cord-298169-2133gahl 168 14 shaped shape VBN cord-298169-2133gahl 168 15 by by IN cord-298169-2133gahl 168 16 various various JJ cord-298169-2133gahl 168 17 environmental environmental JJ cord-298169-2133gahl 168 18 pressures pressure NNS cord-298169-2133gahl 168 19 over over IN cord-298169-2133gahl 168 20 time time NN cord-298169-2133gahl 168 21 , , , cord-298169-2133gahl 168 22 including include VBG cord-298169-2133gahl 168 23 a a DT cord-298169-2133gahl 168 24 variety variety NN cord-298169-2133gahl 168 25 of of IN cord-298169-2133gahl 168 26 social social JJ cord-298169-2133gahl 168 27 and and CC cord-298169-2133gahl 168 28 microbial microbial JJ cord-298169-2133gahl 168 29 pressures pressure NNS cord-298169-2133gahl 168 30 , , , cord-298169-2133gahl 168 31 will will MD cord-298169-2133gahl 168 32 be be VB cord-298169-2133gahl 168 33 pivotal pivotal JJ cord-298169-2133gahl 168 34 for for IN cord-298169-2133gahl 168 35 the the DT cord-298169-2133gahl 168 36 understanding understanding NN cord-298169-2133gahl 168 37 of of IN cord-298169-2133gahl 168 38 psychiatric psychiatric JJ cord-298169-2133gahl 168 39 disorders disorder NNS cord-298169-2133gahl 168 40 . . . cord-298169-2133gahl 169 1 As as IN cord-298169-2133gahl 169 2 highlighted highlight VBN cord-298169-2133gahl 169 3 in in IN cord-298169-2133gahl 169 4 this this DT cord-298169-2133gahl 169 5 review review NN cord-298169-2133gahl 169 6 HLA HLA NNP cord-298169-2133gahl 169 7 diversity diversity NN cord-298169-2133gahl 169 8 is be VBZ cord-298169-2133gahl 169 9 integral integral JJ cord-298169-2133gahl 169 10 to to IN cord-298169-2133gahl 169 11 variations variation NNS cord-298169-2133gahl 169 12 in in IN cord-298169-2133gahl 169 13 the the DT cord-298169-2133gahl 169 14 immune immune JJ cord-298169-2133gahl 169 15 responses response NNS cord-298169-2133gahl 169 16 that that WDT cord-298169-2133gahl 169 17 form form VBP cord-298169-2133gahl 169 18 biological biological JJ cord-298169-2133gahl 169 19 underpinnings underpinning NNS cord-298169-2133gahl 169 20 , , , cord-298169-2133gahl 169 21 among among IN cord-298169-2133gahl 169 22 others other NNS cord-298169-2133gahl 169 23 and and CC cord-298169-2133gahl 169 24 likely likely JJ cord-298169-2133gahl 169 25 in in IN cord-298169-2133gahl 169 26 subsets subset NNS cord-298169-2133gahl 169 27 of of IN cord-298169-2133gahl 169 28 patients patient NNS cord-298169-2133gahl 169 29 , , , cord-298169-2133gahl 169 30 of of IN cord-298169-2133gahl 169 31 a a DT cord-298169-2133gahl 169 32 wide wide JJ cord-298169-2133gahl 169 33 array array NN cord-298169-2133gahl 169 34 of of IN cord-298169-2133gahl 169 35 psychiatric psychiatric JJ cord-298169-2133gahl 169 36 presentations presentation NNS cord-298169-2133gahl 169 37 as as RB cord-298169-2133gahl 169 38 well well RB cord-298169-2133gahl 169 39 as as IN cord-298169-2133gahl 169 40 to to IN cord-298169-2133gahl 169 41 how how WRB cord-298169-2133gahl 169 42 we -PRON- PRP cord-298169-2133gahl 169 43 , , , cord-298169-2133gahl 169 44 and and CC cord-298169-2133gahl 169 45 other other JJ cord-298169-2133gahl 169 46 animals animal NNS cord-298169-2133gahl 169 47 , , , cord-298169-2133gahl 169 48 have have VBP cord-298169-2133gahl 169 49 interacted interact VBN cord-298169-2133gahl 169 50 with with IN cord-298169-2133gahl 169 51 viruses virus NNS cord-298169-2133gahl 169 52 over over IN cord-298169-2133gahl 169 53 the the DT cord-298169-2133gahl 169 54 course course NN cord-298169-2133gahl 169 55 of of IN cord-298169-2133gahl 169 56 evolution evolution NN cord-298169-2133gahl 169 57 . . . cord-298169-2133gahl 170 1 Relevant relevant JJ cord-298169-2133gahl 170 2 papers paper NNS cord-298169-2133gahl 170 3 were be VBD cord-298169-2133gahl 170 4 identified identify VBN cord-298169-2133gahl 170 5 through through IN cord-298169-2133gahl 170 6 PubMed PubMed NNP cord-298169-2133gahl 170 7 searches search NNS cord-298169-2133gahl 170 8 of of IN cord-298169-2133gahl 170 9 articles article NNS cord-298169-2133gahl 170 10 published publish VBN cord-298169-2133gahl 170 11 in in IN cord-298169-2133gahl 170 12 English English NNP cord-298169-2133gahl 170 13 from from IN cord-298169-2133gahl 170 14 Jan Jan NNP cord-298169-2133gahl 170 15 1 1 CD cord-298169-2133gahl 170 16 , , , cord-298169-2133gahl 170 17 1955 1955 CD cord-298169-2133gahl 170 18 , , , cord-298169-2133gahl 170 19 up up IN cord-298169-2133gahl 170 20 to to IN cord-298169-2133gahl 170 21 April April NNP cord-298169-2133gahl 170 22 30 30 CD cord-298169-2133gahl 170 23 , , , cord-298169-2133gahl 170 24 2020 2020 CD cord-298169-2133gahl 170 25 , , , cord-298169-2133gahl 170 26 using use VBG cord-298169-2133gahl 170 27 the the DT cord-298169-2133gahl 170 28 following follow VBG cord-298169-2133gahl 170 29 search search NN cord-298169-2133gahl 170 30 terms term NNS cord-298169-2133gahl 170 31 ( ( -LRB- cord-298169-2133gahl 170 32 alone alone RB cord-298169-2133gahl 170 33 or or CC cord-298169-2133gahl 170 34 in in IN cord-298169-2133gahl 170 35 combination combination NN cord-298169-2133gahl 170 36 ) ) -RRB- cord-298169-2133gahl 170 37 : : : cord-298169-2133gahl 170 38 " " `` cord-298169-2133gahl 170 39 HLA HLA NNP cord-298169-2133gahl 170 40 , , , cord-298169-2133gahl 170 41 MHC MHC NNP cord-298169-2133gahl 170 42 , , , cord-298169-2133gahl 170 43 psychiatry psychiatry NN cord-298169-2133gahl 170 44 , , , cord-298169-2133gahl 170 45 polymorphism polymorphism NN cord-298169-2133gahl 170 46 , , , cord-298169-2133gahl 170 47 immunogenetics immunogenetic NNS cord-298169-2133gahl 170 48 , , , cord-298169-2133gahl 170 49 immuno immuno JJ cord-298169-2133gahl 170 50 - - NN cord-298169-2133gahl 170 51 psychiatry psychiatry NN cord-298169-2133gahl 170 52 , , , cord-298169-2133gahl 170 53 Covid Covid NNP cord-298169-2133gahl 170 54 " " '' cord-298169-2133gahl 170 55 . . . cord-298169-2133gahl 171 1 Additional additional JJ cord-298169-2133gahl 171 2 studies study NNS cord-298169-2133gahl 171 3 were be VBD cord-298169-2133gahl 171 4 identified identify VBN cord-298169-2133gahl 171 5 from from IN cord-298169-2133gahl 171 6 our -PRON- PRP$ cord-298169-2133gahl 171 7 own own JJ cord-298169-2133gahl 171 8 files file NNS cord-298169-2133gahl 171 9 . . . cord-298169-2133gahl 172 1 The the DT cord-298169-2133gahl 172 2 final final JJ cord-298169-2133gahl 172 3 reference reference NN cord-298169-2133gahl 172 4 list list NN cord-298169-2133gahl 172 5 was be VBD cord-298169-2133gahl 172 6 generated generate VBN cord-298169-2133gahl 172 7 on on IN cord-298169-2133gahl 172 8 the the DT cord-298169-2133gahl 172 9 basis basis NN cord-298169-2133gahl 172 10 of of IN cord-298169-2133gahl 172 11 their -PRON- PRP$ cord-298169-2133gahl 172 12 relevance relevance NN cord-298169-2133gahl 172 13 to to IN cord-298169-2133gahl 172 14 the the DT cord-298169-2133gahl 172 15 topics topic NNS cord-298169-2133gahl 172 16 covered cover VBN cord-298169-2133gahl 172 17 in in IN cord-298169-2133gahl 172 18 this this DT cord-298169-2133gahl 172 19 review review NN cord-298169-2133gahl 172 20 . . . cord-298169-2133gahl 173 1 The the DT cord-298169-2133gahl 173 2 authors author NNS cord-298169-2133gahl 173 3 declare declare VBP cord-298169-2133gahl 173 4 that that IN cord-298169-2133gahl 173 5 they -PRON- PRP cord-298169-2133gahl 173 6 have have VBP cord-298169-2133gahl 173 7 no no DT cord-298169-2133gahl 173 8 competing compete VBG cord-298169-2133gahl 173 9 financial financial JJ cord-298169-2133gahl 173 10 interests interest NNS cord-298169-2133gahl 173 11 or or CC cord-298169-2133gahl 173 12 personal personal JJ cord-298169-2133gahl 173 13 relationships relationship NNS cord-298169-2133gahl 173 14 that that WDT cord-298169-2133gahl 173 15 could could MD cord-298169-2133gahl 173 16 have have VB cord-298169-2133gahl 173 17 appeared appear VBN cord-298169-2133gahl 173 18 to to TO cord-298169-2133gahl 173 19 influence influence VB cord-298169-2133gahl 173 20 the the DT cord-298169-2133gahl 173 21 work work NN cord-298169-2133gahl 173 22 reported report VBN cord-298169-2133gahl 173 23 in in IN cord-298169-2133gahl 173 24 this this DT cord-298169-2133gahl 173 25 paper paper NN cord-298169-2133gahl 173 26 . . . cord-298169-2133gahl 174 1 This this DT cord-298169-2133gahl 174 2 review review NN cord-298169-2133gahl 174 3 was be VBD cord-298169-2133gahl 174 4 written write VBN cord-298169-2133gahl 174 5 under under IN cord-298169-2133gahl 174 6 the the DT cord-298169-2133gahl 174 7 framework framework NN cord-298169-2133gahl 174 8 of of IN cord-298169-2133gahl 174 9 Agence Agence NNP cord-298169-2133gahl 174 10 Nationale Nationale NNP cord-298169-2133gahl 174 11 de de NNP cord-298169-2133gahl 174 12 la la FW cord-298169-2133gahl 174 13 Recherche Recherche NNP cord-298169-2133gahl 174 14 ( ( -LRB- cord-298169-2133gahl 174 15 I i NN cord-298169-2133gahl 174 16 - - HYPH cord-298169-2133gahl 174 17 GIVE give VB cord-298169-2133gahl 174 18 ANR-13-SAMA-0004 ANR-13-SAMA-0004 NNP cord-298169-2133gahl 174 19 - - HYPH cord-298169-2133gahl 174 20 01 01 CD cord-298169-2133gahl 174 21 ) ) -RRB- cord-298169-2133gahl 174 22 , , , cord-298169-2133gahl 174 23 INSERM INSERM NNP cord-298169-2133gahl 174 24 ( ( -LRB- cord-298169-2133gahl 174 25 Institut Institut NNP cord-298169-2133gahl 174 26 National National NNP cord-298169-2133gahl 174 27 de de NNP cord-298169-2133gahl 174 28 la la FW cord-298169-2133gahl 174 29 Santé Santé NNP cord-298169-2133gahl 174 30 et et FW cord-298169-2133gahl 174 31 de de FW cord-298169-2133gahl 174 32 la la FW cord-298169-2133gahl 174 33 Recherche Recherche NNP cord-298169-2133gahl 174 34 Médicale Médicale NNP cord-298169-2133gahl 174 35 ) ) -RRB- cord-298169-2133gahl 174 36 and and CC cord-298169-2133gahl 174 37 Fondation Fondation NNP cord-298169-2133gahl 174 38 FondaMental FondaMental NNP cord-298169-2133gahl 174 39 however however RB cord-298169-2133gahl 174 40 without without IN cord-298169-2133gahl 174 41 any any DT cord-298169-2133gahl 174 42 role role NN cord-298169-2133gahl 174 43 of of IN cord-298169-2133gahl 174 44 the the DT cord-298169-2133gahl 174 45 above above RB cord-298169-2133gahl 174 46 - - HYPH cord-298169-2133gahl 174 47 mentioned mention VBN cord-298169-2133gahl 174 48 institutions institution NNS cord-298169-2133gahl 174 49 in in IN cord-298169-2133gahl 174 50 study study NN cord-298169-2133gahl 174 51 design design NN cord-298169-2133gahl 174 52 ; ; : cord-298169-2133gahl 174 53 in in IN cord-298169-2133gahl 174 54 the the DT cord-298169-2133gahl 174 55 collection collection NN cord-298169-2133gahl 174 56 , , , cord-298169-2133gahl 174 57 analysis analysis NN cord-298169-2133gahl 174 58 , , , cord-298169-2133gahl 174 59 and and CC cord-298169-2133gahl 174 60 interpretation interpretation NN cord-298169-2133gahl 174 61 of of IN cord-298169-2133gahl 174 62 data datum NNS cord-298169-2133gahl 174 63 ; ; : cord-298169-2133gahl 174 64 in in IN cord-298169-2133gahl 174 65 the the DT cord-298169-2133gahl 174 66 writing writing NN cord-298169-2133gahl 174 67 of of IN cord-298169-2133gahl 174 68 the the DT cord-298169-2133gahl 174 69 report report NN cord-298169-2133gahl 174 70 ; ; : cord-298169-2133gahl 174 71 and and CC cord-298169-2133gahl 174 72 in in IN cord-298169-2133gahl 174 73 the the DT cord-298169-2133gahl 174 74 decision decision NN cord-298169-2133gahl 174 75 to to TO cord-298169-2133gahl 174 76 submit submit VB cord-298169-2133gahl 174 77 the the DT cord-298169-2133gahl 174 78 review review NN cord-298169-2133gahl 174 79 for for IN cord-298169-2133gahl 174 80 publication publication NN cord-298169-2133gahl 174 81 . . . cord-298169-2133gahl 175 1 RT RT NNP cord-298169-2133gahl 175 2 : : : cord-298169-2133gahl 175 3 designed design VBN cord-298169-2133gahl 175 4 the the DT cord-298169-2133gahl 175 5 search search NN cord-298169-2133gahl 175 6 strategy strategy NN cord-298169-2133gahl 175 7 and and CC cord-298169-2133gahl 175 8 performed perform VBD cord-298169-2133gahl 175 9 it -PRON- PRP cord-298169-2133gahl 175 10 , , , cord-298169-2133gahl 175 11 wrote write VBD cord-298169-2133gahl 175 12 the the DT cord-298169-2133gahl 175 13 manuscript manuscript NN cord-298169-2133gahl 175 14 and and CC cord-298169-2133gahl 175 15 take take VB cord-298169-2133gahl 175 16 the the DT cord-298169-2133gahl 175 17 primary primary JJ cord-298169-2133gahl 175 18 responsibility responsibility NN cord-298169-2133gahl 175 19 to to TO cord-298169-2133gahl 175 20 submit submit VB cord-298169-2133gahl 175 21 the the DT cord-298169-2133gahl 175 22 review review NN cord-298169-2133gahl 175 23 . . . cord-298169-2133gahl 176 1 RK RK NNP cord-298169-2133gahl 176 2 and and CC cord-298169-2133gahl 176 3 ML ML NNP cord-298169-2133gahl 176 4 : : : cord-298169-2133gahl 176 5 participated participate VBD cord-298169-2133gahl 176 6 to to IN cord-298169-2133gahl 176 7 the the DT cord-298169-2133gahl 176 8 search search NN cord-298169-2133gahl 176 9 strategy strategy NN cord-298169-2133gahl 176 10 , , , cord-298169-2133gahl 176 11 critically critically RB cord-298169-2133gahl 176 12 reviewed review VBN cord-298169-2133gahl 176 13 and and CC cord-298169-2133gahl 176 14 edited edit VBD cord-298169-2133gahl 176 15 the the DT cord-298169-2133gahl 176 16 manuscript manuscript NN cord-298169-2133gahl 176 17 . . . cord-298169-2133gahl 177 1 All all DT cord-298169-2133gahl 177 2 authors author NNS cord-298169-2133gahl 177 3 approved approve VBD cord-298169-2133gahl 177 4 the the DT cord-298169-2133gahl 177 5 final final JJ cord-298169-2133gahl 177 6 version version NN cord-298169-2133gahl 177 7 . . . cord-298169-2133gahl 178 1   NFP cord-298169-2133gahl 179 1 Major major JJ cord-298169-2133gahl 179 2 psychiatric psychiatric JJ cord-298169-2133gahl 179 3 disorders disorder NNS cord-298169-2133gahl 179 4 are be VBP cord-298169-2133gahl 179 5 associated associate VBN cord-298169-2133gahl 179 6 with with IN cord-298169-2133gahl 179 7 genetically genetically RB cord-298169-2133gahl 179 8 - - HYPH cord-298169-2133gahl 179 9 determined determine VBN cord-298169-2133gahl 179 10 immune immune JJ cord-298169-2133gahl 179 11 dysfunctions dysfunction NNS cord-298169-2133gahl 179 12   . cord-298169-2133gahl 180 1 Human human JJ cord-298169-2133gahl 180 2 leukocyte leukocyte NN cord-298169-2133gahl 180 3 antigen antigen NN cord-298169-2133gahl 180 4 ( ( -LRB- cord-298169-2133gahl 180 5 HLA HLA NNP cord-298169-2133gahl 180 6 ) ) -RRB- cord-298169-2133gahl 180 7 molecules molecule NNS cord-298169-2133gahl 180 8 are be VBP cord-298169-2133gahl 180 9 prominent prominent JJ cord-298169-2133gahl 180 10 players player NNS cord-298169-2133gahl 180 11 of of IN cord-298169-2133gahl 180 12 immune immune JJ cord-298169-2133gahl 180 13 and and CC cord-298169-2133gahl 180 14 neurodevelopmental neurodevelopmental JJ cord-298169-2133gahl 180 15 processes process NNS cord-298169-2133gahl 180 16 . . . cord-298169-2133gahl 181 1   NFP cord-298169-2133gahl 182 1 HLA HLA NNP cord-298169-2133gahl 182 2 molecules molecule NNS cord-298169-2133gahl 182 3 are be VBP cord-298169-2133gahl 182 4 encoded encode VBN cord-298169-2133gahl 182 5 by by IN cord-298169-2133gahl 182 6 polymorphic polymorphic JJ cord-298169-2133gahl 182 7 genes gene NNS cord-298169-2133gahl 182 8 located locate VBN cord-298169-2133gahl 182 9 in in IN cord-298169-2133gahl 182 10 the the DT cord-298169-2133gahl 182 11 major major JJ cord-298169-2133gahl 182 12 histocompatibility histocompatibility NN cord-298169-2133gahl 182 13 complex complex NN cord-298169-2133gahl 182 14 ( ( -LRB- cord-298169-2133gahl 182 15 MHC MHC NNP cord-298169-2133gahl 182 16 ) ) -RRB- cord-298169-2133gahl 182 17 . . . cord-298169-2133gahl 183 1   NFP cord-298169-2133gahl 184 1 Recent recent JJ cord-298169-2133gahl 184 2 methodological methodological JJ cord-298169-2133gahl 184 3 approaches approach NNS cord-298169-2133gahl 184 4 allowed allow VBD cord-298169-2133gahl 184 5 understanding understanding NN cord-298169-2133gahl 184 6 of of IN cord-298169-2133gahl 184 7 the the DT cord-298169-2133gahl 184 8 HLA HLA NNP cord-298169-2133gahl 184 9 genetic genetic JJ cord-298169-2133gahl 184 10 complexity complexity NN cord-298169-2133gahl 184 11 and and CC cord-298169-2133gahl 184 12 reconcile reconcile VB cord-298169-2133gahl 184 13 findings finding NNS cord-298169-2133gahl 184 14 from from IN cord-298169-2133gahl 184 15 GWAS GWAS NNP cord-298169-2133gahl 184 16 in in IN cord-298169-2133gahl 184 17 psychiatry psychiatry NN cord-298169-2133gahl 184 18 . . . cord-298169-2133gahl 185 1   NFP cord-298169-2133gahl 186 1 HLA HLA NNP cord-298169-2133gahl 186 2 haplotypes haplotype NNS cord-298169-2133gahl 186 3 studies study NNS cord-298169-2133gahl 186 4 uncover uncover VBP cord-298169-2133gahl 186 5 protective protective JJ cord-298169-2133gahl 186 6 and and CC cord-298169-2133gahl 186 7 at at IN cord-298169-2133gahl 186 8 risk risk NN cord-298169-2133gahl 186 9 markers marker NNS cord-298169-2133gahl 186 10 for for IN cord-298169-2133gahl 186 11 disease disease NN cord-298169-2133gahl 186 12 development development NN cord-298169-2133gahl 186 13 or or CC cord-298169-2133gahl 186 14 proxies proxy NNS cord-298169-2133gahl 186 15 of of IN cord-298169-2133gahl 186 16 severity severity NN cord-298169-2133gahl 186 17 in in IN cord-298169-2133gahl 186 18 schizophrenia schizophrenia NN cord-298169-2133gahl 186 19 , , , cord-298169-2133gahl 186 20 autism autism NN cord-298169-2133gahl 186 21 and and CC cord-298169-2133gahl 186 22 bipolar bipolar JJ cord-298169-2133gahl 186 23 disorders disorder NNS cord-298169-2133gahl 186 24 . . . cord-298169-2133gahl 187 1   NFP cord-298169-2133gahl 188 1 Beyond beyond IN cord-298169-2133gahl 188 2 disease disease NN cord-298169-2133gahl 188 3 risk risk NN cord-298169-2133gahl 188 4 , , , cord-298169-2133gahl 188 5 the the DT cord-298169-2133gahl 188 6 HLA HLA NNP cord-298169-2133gahl 188 7 genetic genetic JJ cord-298169-2133gahl 188 8 diversity diversity NN cord-298169-2133gahl 188 9 is be VBZ cord-298169-2133gahl 188 10 associated associate VBN cord-298169-2133gahl 188 11 with with IN cord-298169-2133gahl 188 12 autoimmune autoimmune JJ cord-298169-2133gahl 188 13 encephalitis encephalitis RB cord-298169-2133gahl 188 14 , , , cord-298169-2133gahl 188 15 treatment treatment NN cord-298169-2133gahl 188 16 response response NN cord-298169-2133gahl 188 17 , , , cord-298169-2133gahl 188 18 retrovirology retrovirology NN cord-298169-2133gahl 188 19 and and CC cord-298169-2133gahl 188 20 neurodevelopmental neurodevelopmental JJ cord-298169-2133gahl 188 21 immunomodulation immunomodulation NN cord-298169-2133gahl 188 22 . . . cord-298169-2133gahl 189 1   NFP cord-298169-2133gahl 190 1 HLA HLA NNP cord-298169-2133gahl 190 2 is be VBZ cord-298169-2133gahl 190 3 also also RB cord-298169-2133gahl 190 4 involved involve VBN cord-298169-2133gahl 190 5 in in IN cord-298169-2133gahl 190 6 anti anti JJ cord-298169-2133gahl 190 7 - - NNS cord-298169-2133gahl 190 8 infections infection NNS cord-298169-2133gahl 190 9 processes process NNS cord-298169-2133gahl 190 10 including include VBG cord-298169-2133gahl 190 11 against against IN cord-298169-2133gahl 190 12 the the DT cord-298169-2133gahl 190 13 coronavirus coronavirus NN cord-298169-2133gahl 190 14 family family NN cord-298169-2133gahl 190 15 Common common JJ cord-298169-2133gahl 190 16 sequence sequence NN cord-298169-2133gahl 190 17 variants variant NNS cord-298169-2133gahl 190 18 in in IN cord-298169-2133gahl 190 19 the the DT cord-298169-2133gahl 190 20 major major JJ cord-298169-2133gahl 190 21 histocompatibility histocompatibility NN cord-298169-2133gahl 190 22 complex complex JJ cord-298169-2133gahl 190 23 region region NN cord-298169-2133gahl 190 24 associate associate NN cord-298169-2133gahl 190 25 with with IN cord-298169-2133gahl 190 26 cerebral cerebral JJ cord-298169-2133gahl 190 27 ventricular ventricular JJ cord-298169-2133gahl 190 28 size size NN cord-298169-2133gahl 190 29 in in IN cord-298169-2133gahl 190 30 schizophrenia schizophrenia NNP cord-298169-2133gahl 190 31 Expression Expression NNP cord-298169-2133gahl 190 32 estimation estimation NN cord-298169-2133gahl 190 33 and and CC cord-298169-2133gahl 190 34 eQTL eqtl NN cord-298169-2133gahl 190 35 mapping mapping NN cord-298169-2133gahl 190 36 for for IN cord-298169-2133gahl 190 37 HLA HLA NNP cord-298169-2133gahl 190 38 genes gene NNS cord-298169-2133gahl 190 39 with with IN cord-298169-2133gahl 190 40 a a DT cord-298169-2133gahl 190 41 personalized personalized JJ cord-298169-2133gahl 190 42 pipeline pipeline NN cord-298169-2133gahl 190 43 Association Association NNP cord-298169-2133gahl 190 44 of of IN cord-298169-2133gahl 190 45 Polygenic Polygenic NNP cord-298169-2133gahl 190 46 Score Score NNP cord-298169-2133gahl 190 47 for for IN cord-298169-2133gahl 190 48 Schizophrenia Schizophrenia NNP cord-298169-2133gahl 190 49 and and CC cord-298169-2133gahl 190 50 HLA HLA NNP cord-298169-2133gahl 190 51 Antigen Antigen NNP cord-298169-2133gahl 190 52 and and CC cord-298169-2133gahl 190 53 Inflammation inflammation NN cord-298169-2133gahl 190 54 Genes Genes NNPS cord-298169-2133gahl 190 55 With with IN cord-298169-2133gahl 190 56 Response response NN cord-298169-2133gahl 190 57 to to IN cord-298169-2133gahl 190 58 Lithium Lithium NNP cord-298169-2133gahl 190 59 in in IN cord-298169-2133gahl 190 60 Bipolar Bipolar NNP cord-298169-2133gahl 190 61 Affective Affective NNP cord-298169-2133gahl 190 62 Disorder Disorder NNP cord-298169-2133gahl 190 63 : : : cord-298169-2133gahl 191 1 A a DT cord-298169-2133gahl 191 2 Genome Genome NNP cord-298169-2133gahl 191 3 - - HYPH cord-298169-2133gahl 191 4 Wide Wide NNP cord-298169-2133gahl 191 5 Association Association NNP cord-298169-2133gahl 191 6 Study Study NNP cord-298169-2133gahl 191 7 Study Study NNP cord-298169-2133gahl 191 8 of of IN cord-298169-2133gahl 191 9 the the DT cord-298169-2133gahl 191 10 leukocyte leukocyte NN cord-298169-2133gahl 191 11 phenotypes phenotype NNS cord-298169-2133gahl 191 12 in in IN cord-298169-2133gahl 191 13 Hodgkin Hodgkin NNP cord-298169-2133gahl 191 14 's 's POS cord-298169-2133gahl 191 15 disease disease NN cord-298169-2133gahl 191 16 Genetic genetic JJ cord-298169-2133gahl 191 17 pleiotropy pleiotropy NN cord-298169-2133gahl 191 18 between between IN cord-298169-2133gahl 191 19 multiple multiple JJ cord-298169-2133gahl 191 20 sclerosis sclerosis NN cord-298169-2133gahl 191 21 and and CC cord-298169-2133gahl 191 22 schizophrenia schizophrenia NN cord-298169-2133gahl 191 23 but but CC cord-298169-2133gahl 191 24 not not RB cord-298169-2133gahl 191 25 bipolar bipolar JJ cord-298169-2133gahl 191 26 disorder disorder NN cord-298169-2133gahl 191 27 : : : cord-298169-2133gahl 191 28 differential differential JJ cord-298169-2133gahl 191 29 involvement involvement NN cord-298169-2133gahl 191 30 of of IN cord-298169-2133gahl 191 31 immune immune NN cord-298169-2133gahl 191 32 - - HYPH cord-298169-2133gahl 191 33 related relate VBN cord-298169-2133gahl 191 34 gene gene NN cord-298169-2133gahl 191 35 loci locus NNS cord-298169-2133gahl 191 36 Influence influence NN cord-298169-2133gahl 191 37 of of IN cord-298169-2133gahl 191 38 HLA HLA NNP cord-298169-2133gahl 191 39 - - HYPH cord-298169-2133gahl 191 40 C C NNP cord-298169-2133gahl 191 41 expression expression NN cord-298169-2133gahl 191 42 level level NN cord-298169-2133gahl 191 43 on on IN cord-298169-2133gahl 191 44 HIV HIV NNP cord-298169-2133gahl 191 45 control control NN cord-298169-2133gahl 191 46 Infection infection NN cord-298169-2133gahl 191 47 and and CC cord-298169-2133gahl 191 48 inflammation inflammation NN cord-298169-2133gahl 191 49 in in IN cord-298169-2133gahl 191 50 schizophrenia schizophrenia NN cord-298169-2133gahl 191 51 and and CC cord-298169-2133gahl 191 52 bipolar bipolar JJ cord-298169-2133gahl 191 53 disorder disorder NN cord-298169-2133gahl 191 54 : : : cord-298169-2133gahl 191 55 a a DT cord-298169-2133gahl 191 56 genome genome NN cord-298169-2133gahl 191 57 wide wide JJ cord-298169-2133gahl 191 58 study study NN cord-298169-2133gahl 191 59 for for IN cord-298169-2133gahl 191 60 interactions interaction NNS cord-298169-2133gahl 191 61 with with IN cord-298169-2133gahl 191 62 genetic genetic JJ cord-298169-2133gahl 191 63 variation variation NN cord-298169-2133gahl 191 64 HLA HLA NNP cord-298169-2133gahl 191 65 - - HYPH cord-298169-2133gahl 191 66 class class NN cord-298169-2133gahl 191 67 II II NNP cord-298169-2133gahl 191 68 haplotypes haplotype NNS cord-298169-2133gahl 191 69 and and CC cord-298169-2133gahl 191 70 Genome Genome NNP cord-298169-2133gahl 191 71 - - HYPH cord-298169-2133gahl 191 72 wide wide JJ cord-298169-2133gahl 191 73 association association NN cord-298169-2133gahl 191 74 study study NN cord-298169-2133gahl 191 75 in in IN cord-298169-2133gahl 191 76 a a DT cord-298169-2133gahl 191 77 Swedish swedish JJ cord-298169-2133gahl 191 78 population population NN cord-298169-2133gahl 191 79 yields yield NNS cord-298169-2133gahl 191 80 support support NN cord-298169-2133gahl 191 81 for for IN cord-298169-2133gahl 191 82 greater great JJR cord-298169-2133gahl 191 83 CNV CNV NNP cord-298169-2133gahl 191 84 and and CC cord-298169-2133gahl 191 85 MHC MHC NNP cord-298169-2133gahl 191 86 involvement involvement NN cord-298169-2133gahl 191 87 in in IN cord-298169-2133gahl 191 88 schizophrenia schizophrenia NN cord-298169-2133gahl 191 89 compared compare VBN cord-298169-2133gahl 191 90 with with IN cord-298169-2133gahl 191 91 bipolar bipolar JJ cord-298169-2133gahl 191 92 disorder disorder NN cord-298169-2133gahl 191 93 Distinct Distinct NNP cord-298169-2133gahl 191 94 HLA HLA NNP cord-298169-2133gahl 191 95 associations association NNS cord-298169-2133gahl 191 96 of of IN cord-298169-2133gahl 191 97 LGI1 LGI1 NNP cord-298169-2133gahl 191 98 and and CC cord-298169-2133gahl 191 99 CASPR2-antibody CASPR2-antibody NNP cord-298169-2133gahl 191 100 diseases disease NNS cord-298169-2133gahl 191 101 Combining combine VBG cord-298169-2133gahl 191 102 clinical clinical JJ cord-298169-2133gahl 191 103 and and CC cord-298169-2133gahl 191 104 molecular molecular JJ cord-298169-2133gahl 191 105 heterogeneity heterogeneity NN cord-298169-2133gahl 191 106 within within IN cord-298169-2133gahl 191 107 CASPR2-antibody CASPR2-antibody NNP cord-298169-2133gahl 191 108 mediated mediate VBN cord-298169-2133gahl 191 109 diseases disease NNS cord-298169-2133gahl 191 110 : : : cord-298169-2133gahl 191 111 towards towards IN cord-298169-2133gahl 191 112 the the DT cord-298169-2133gahl 191 113 underlying underlie VBG cord-298169-2133gahl 191 114 disease disease NN cord-298169-2133gahl 191 115 biology biology NN cord-298169-2133gahl 191 116 Immune immune VBP cord-298169-2133gahl 191 117 proteins protein NNS cord-298169-2133gahl 191 118 in in IN cord-298169-2133gahl 191 119 brain brain NN cord-298169-2133gahl 191 120 development development NN cord-298169-2133gahl 191 121 and and CC cord-298169-2133gahl 191 122 synaptic synaptic JJ cord-298169-2133gahl 191 123 plasticity plasticity NN cord-298169-2133gahl 191 124 Thinning thinning NN cord-298169-2133gahl 192 1 Faster fast RBR cord-298169-2133gahl 192 2 ? ? . cord-298169-2133gahl 193 1 Age age NN cord-298169-2133gahl 193 2 - - HYPH cord-298169-2133gahl 193 3 Related relate VBN cord-298169-2133gahl 193 4 Cortical Cortical NNP cord-298169-2133gahl 193 5 Thickness Thickness NNP cord-298169-2133gahl 193 6 Differences difference NNS cord-298169-2133gahl 193 7 in in IN cord-298169-2133gahl 193 8 Adults Adults NNPS cord-298169-2133gahl 193 9 with with IN cord-298169-2133gahl 193 10 Prenatal prenatal JJ cord-298169-2133gahl 193 11 infection infection NN cord-298169-2133gahl 193 12 and and CC cord-298169-2133gahl 193 13 schizophrenia schizophrenia NN cord-298169-2133gahl 193 14 : : : cord-298169-2133gahl 194 1 a a DT cord-298169-2133gahl 194 2 review review NN cord-298169-2133gahl 194 3 of of IN cord-298169-2133gahl 194 4 epidemiologic epidemiologic JJ cord-298169-2133gahl 194 5 and and CC cord-298169-2133gahl 194 6 translational translational JJ cord-298169-2133gahl 194 7 studies study NNS cord-298169-2133gahl 194 8 HLA HLA NNP cord-298169-2133gahl 194 9 system system NN cord-298169-2133gahl 194 10 , , , cord-298169-2133gahl 194 11 psychiatry psychiatry NN cord-298169-2133gahl 194 12 and and CC cord-298169-2133gahl 194 13 psychopharmacology psychopharmacology NN cord-298169-2133gahl 194 14 Comprehensive Comprehensive NNP cord-298169-2133gahl 194 15 meta meta NNP cord-298169-2133gahl 194 16 - - HYPH cord-298169-2133gahl 194 17 analysis analysis NN cord-298169-2133gahl 194 18 reveals reveal VBZ cord-298169-2133gahl 194 19 an an DT cord-298169-2133gahl 194 20 association association NN cord-298169-2133gahl 194 21 of of IN cord-298169-2133gahl 194 22 the the DT cord-298169-2133gahl 194 23 HLA HLA NNP cord-298169-2133gahl 194 24 - - HYPH cord-298169-2133gahl 194 25 DRB1 DRB1 NNP cord-298169-2133gahl 195 1 * * NFP cord-298169-2133gahl 195 2 1602 1602 CD cord-298169-2133gahl 195 3 allele allele NN cord-298169-2133gahl 195 4 with with IN cord-298169-2133gahl 195 5 autoimmune autoimmune JJ cord-298169-2133gahl 195 6 diseases disease NNS cord-298169-2133gahl 195 7 mediated mediate VBN cord-298169-2133gahl 195 8 predominantly predominantly RB cord-298169-2133gahl 195 9 by by IN cord-298169-2133gahl 195 10 autoantibodies autoantibody NNS cord-298169-2133gahl 195 11 Diametrical Diametrical NNP cord-298169-2133gahl 195 12 diseases disease NNS cord-298169-2133gahl 195 13 reflect reflect VBP cord-298169-2133gahl 195 14 evolutionary evolutionary JJ cord-298169-2133gahl 195 15 - - HYPH cord-298169-2133gahl 195 16 genetic genetic JJ cord-298169-2133gahl 195 17 tradeoffs tradeoff NNS cord-298169-2133gahl 195 18 : : : cord-298169-2133gahl 195 19 Evidence evidence NN cord-298169-2133gahl 195 20 from from IN cord-298169-2133gahl 195 21 psychiatry psychiatry NN cord-298169-2133gahl 195 22 , , , cord-298169-2133gahl 195 23 neurology neurology NN cord-298169-2133gahl 195 24 , , , cord-298169-2133gahl 195 25 rheumatology rheumatology NN cord-298169-2133gahl 195 26 , , , cord-298169-2133gahl 195 27 oncology oncology NN cord-298169-2133gahl 195 28 and and CC cord-298169-2133gahl 195 29 immunology immunology NN cord-298169-2133gahl 196 1 The the DT cord-298169-2133gahl 196 2 immunological immunological JJ cord-298169-2133gahl 196 3 synapse synapse NN cord-298169-2133gahl 196 4 Group Group NNP cord-298169-2133gahl 196 5 of of IN cord-298169-2133gahl 196 6 the the DT cord-298169-2133gahl 196 7 Psychiatric Psychiatric NNP cord-298169-2133gahl 196 8 Genomics Genomics NNPS cord-298169-2133gahl 196 9 Consortium Consortium NNP cord-298169-2133gahl 196 10 . . . cord-298169-2133gahl 197 1 Identification identification NN cord-298169-2133gahl 197 2 of of IN cord-298169-2133gahl 197 3 risk risk NN cord-298169-2133gahl 197 4 loci locus NNS cord-298169-2133gahl 197 5 with with IN cord-298169-2133gahl 197 6 shared share VBN cord-298169-2133gahl 197 7 effects effect NNS cord-298169-2133gahl 197 8 on on IN cord-298169-2133gahl 197 9 five five CD cord-298169-2133gahl 197 10 major major JJ cord-298169-2133gahl 197 11 psychiatric psychiatric JJ cord-298169-2133gahl 197 12 disorders disorder NNS cord-298169-2133gahl 197 13 : : : cord-298169-2133gahl 197 14 a a DT cord-298169-2133gahl 197 15 genome genome NN cord-298169-2133gahl 197 16 - - HYPH cord-298169-2133gahl 197 17 wide wide JJ cord-298169-2133gahl 197 18 analysis analysis NN cord-298169-2133gahl 197 19 Anti Anti NNP cord-298169-2133gahl 197 20 - - JJ cord-298169-2133gahl 197 21 NMDA nmda JJ cord-298169-2133gahl 197 22 - - HYPH cord-298169-2133gahl 197 23 receptor receptor NN cord-298169-2133gahl 197 24 encephalitis encephalitis NN cord-298169-2133gahl 197 25 : : : cord-298169-2133gahl 197 26 case case NNP cord-298169-2133gahl 197 27 series series NN cord-298169-2133gahl 197 28 and and CC cord-298169-2133gahl 197 29 analysis analysis NN cord-298169-2133gahl 197 30 of of IN cord-298169-2133gahl 197 31 the the DT cord-298169-2133gahl 197 32 effects effect NNS cord-298169-2133gahl 197 33 of of IN cord-298169-2133gahl 197 34 antibodies antibody NNS cord-298169-2133gahl 197 35 Systematic systematic JJ cord-298169-2133gahl 197 36 genetic genetic JJ cord-298169-2133gahl 197 37 analysis analysis NN cord-298169-2133gahl 197 38 of of IN cord-298169-2133gahl 197 39 the the DT cord-298169-2133gahl 197 40 MHC MHC NNP cord-298169-2133gahl 197 41 region region NN cord-298169-2133gahl 197 42 reveals reveal VBZ cord-298169-2133gahl 197 43 mechanistic mechanistic JJ cord-298169-2133gahl 197 44 underpinnings underpinning NNS cord-298169-2133gahl 197 45 of of IN cord-298169-2133gahl 197 46 HLA HLA NNP cord-298169-2133gahl 197 47 type type NN cord-298169-2133gahl 197 48 associations association NNS cord-298169-2133gahl 197 49 with with IN cord-298169-2133gahl 197 50 disease disease NN cord-298169-2133gahl 197 51 Identical identical JJ cord-298169-2133gahl 197 52 nature nature NN cord-298169-2133gahl 197 53 of of IN cord-298169-2133gahl 197 54 the the DT cord-298169-2133gahl 197 55 leucocyte leucocyte NN cord-298169-2133gahl 197 56 antigens antigen NNS cord-298169-2133gahl 197 57 detectable detectable JJ cord-298169-2133gahl 197 58 in in IN cord-298169-2133gahl 197 59 monozygotic monozygotic JJ cord-298169-2133gahl 197 60 twins twin NNS cord-298169-2133gahl 197 61 by by IN cord-298169-2133gahl 197 62 means mean NNS cord-298169-2133gahl 197 63 of of IN cord-298169-2133gahl 197 64 immune immune JJ cord-298169-2133gahl 197 65 iso iso NN cord-298169-2133gahl 197 66 - - HYPH cord-298169-2133gahl 197 67 leuco leuco NNP cord-298169-2133gahl 197 68 - - HYPH cord-298169-2133gahl 197 69 agglutinins agglutinins NNP cord-298169-2133gahl 197 70 Genomics Genomics NNPS cord-298169-2133gahl 197 71 of of IN cord-298169-2133gahl 197 72 the the DT cord-298169-2133gahl 197 73 major major JJ cord-298169-2133gahl 197 74 histocompatibility histocompatibility NN cord-298169-2133gahl 197 75 complex complex NN cord-298169-2133gahl 197 76 : : : cord-298169-2133gahl 197 77 haplotypes haplotype NNS cord-298169-2133gahl 197 78 , , , cord-298169-2133gahl 197 79 duplication duplication NN cord-298169-2133gahl 197 80 , , , cord-298169-2133gahl 197 81 retroviruses retrovirus NNS cord-298169-2133gahl 197 82 and and CC cord-298169-2133gahl 197 83 disease disease NN cord-298169-2133gahl 198 1 The the DT cord-298169-2133gahl 198 2 HLA HLA NNP cord-298169-2133gahl 198 3 - - HYPH cord-298169-2133gahl 198 4 G G NNP cord-298169-2133gahl 198 5 low low JJ cord-298169-2133gahl 198 6 expressor expressor NN cord-298169-2133gahl 198 7 genotype genotype NN cord-298169-2133gahl 198 8 is be VBZ cord-298169-2133gahl 198 9 associated associate VBN cord-298169-2133gahl 198 10 with with IN cord-298169-2133gahl 198 11 protection protection NN cord-298169-2133gahl 198 12 against against IN cord-298169-2133gahl 198 13 bipolar bipolar JJ cord-298169-2133gahl 198 14 disorder disorder NN cord-298169-2133gahl 199 1 The the DT cord-298169-2133gahl 199 2 MHC MHC NNP cord-298169-2133gahl 199 3 / / SYM cord-298169-2133gahl 199 4 HLA HLA NNP cord-298169-2133gahl 199 5 Gene Gene NNP cord-298169-2133gahl 199 6 Complex Complex NNP cord-298169-2133gahl 199 7 in in IN cord-298169-2133gahl 199 8 Major Major NNP cord-298169-2133gahl 199 9 Psychiatric Psychiatric NNP cord-298169-2133gahl 199 10 Disorders Disorders NNPS cord-298169-2133gahl 199 11 : : : cord-298169-2133gahl 199 12 Emerging emerge VBG cord-298169-2133gahl 199 13 Roles Roles NNPS cord-298169-2133gahl 199 14 and and CC cord-298169-2133gahl 199 15 Implications Implications NNPS cord-298169-2133gahl 199 16 HLA HLA NNP cord-298169-2133gahl 199 17 variation variation NN cord-298169-2133gahl 199 18 and and CC cord-298169-2133gahl 199 19 disease disease NN cord-298169-2133gahl 199 20 Irish Irish NNP cord-298169-2133gahl 199 21 Schizophrenia Schizophrenia NNP cord-298169-2133gahl 199 22 Genomics Genomics NNP cord-298169-2133gahl 199 23 Consortium Consortium NNP cord-298169-2133gahl 199 24 and and CC cord-298169-2133gahl 199 25 the the DT cord-298169-2133gahl 199 26 Wellcome Wellcome NNP cord-298169-2133gahl 199 27 Trust Trust NNP cord-298169-2133gahl 199 28 Case Case NNP cord-298169-2133gahl 199 29 Control Control NNP cord-298169-2133gahl 199 30 Consortium Consortium NNP cord-298169-2133gahl 199 31 2 2 CD cord-298169-2133gahl 199 32 . . . cord-298169-2133gahl 200 1 Genome genome NN cord-298169-2133gahl 200 2 - - HYPH cord-298169-2133gahl 200 3 wide wide JJ cord-298169-2133gahl 200 4 association association NN cord-298169-2133gahl 200 5 study study NN cord-298169-2133gahl 200 6 implicates implicate VBZ cord-298169-2133gahl 200 7 HLA HLA NNP cord-298169-2133gahl 200 8 - - HYPH cord-298169-2133gahl 200 9 C*01:02 C*01:02 NNP cord-298169-2133gahl 200 10 as as IN cord-298169-2133gahl 200 11 a a DT cord-298169-2133gahl 200 12 risk risk NN cord-298169-2133gahl 200 13 factor factor NN cord-298169-2133gahl 200 14 at at IN cord-298169-2133gahl 200 15 the the DT cord-298169-2133gahl 200 16 major major JJ cord-298169-2133gahl 200 17 histocompatibility histocompatibility NN cord-298169-2133gahl 200 18 complex complex JJ cord-298169-2133gahl 200 19 locus locus NN cord-298169-2133gahl 200 20 in in IN cord-298169-2133gahl 200 21 schizophrenia schizophrenia NN cord-298169-2133gahl 200 22 Isolation isolation NN cord-298169-2133gahl 200 23 and and CC cord-298169-2133gahl 200 24 characterization characterization NN cord-298169-2133gahl 200 25 of of IN cord-298169-2133gahl 200 26 a a DT cord-298169-2133gahl 200 27 protochordate protochordate JJ cord-298169-2133gahl 200 28 histocompatibility histocompatibility NN cord-298169-2133gahl 200 29 locus locus NN cord-298169-2133gahl 200 30 Emerging emerge VBG cord-298169-2133gahl 200 31 Roles Roles NNPS cord-298169-2133gahl 200 32 of of IN cord-298169-2133gahl 200 33 Complement Complement NNP cord-298169-2133gahl 200 34 in in IN cord-298169-2133gahl 200 35 Psychiatric Psychiatric NNP cord-298169-2133gahl 200 36 Disorders Disorders NNPS cord-298169-2133gahl 200 37 Neuroinflammation Neuroinflammation NNP cord-298169-2133gahl 200 38 as as IN cord-298169-2133gahl 200 39 a a DT cord-298169-2133gahl 200 40 risk risk NN cord-298169-2133gahl 200 41 factor factor NN cord-298169-2133gahl 200 42 for for IN cord-298169-2133gahl 200 43 attention attention NN cord-298169-2133gahl 200 44 deficit deficit NN cord-298169-2133gahl 200 45 hyperactivity hyperactivity NN cord-298169-2133gahl 200 46 disorder disorder NN cord-298169-2133gahl 200 47 Polymorphism polymorphism NN cord-298169-2133gahl 200 48 of of IN cord-298169-2133gahl 200 49 HLA HLA NNP cord-298169-2133gahl 200 50 class class NN cord-298169-2133gahl 200 51 I i NN cord-298169-2133gahl 200 52 and and CC cord-298169-2133gahl 200 53 class class NN cord-298169-2133gahl 200 54 II ii CD cord-298169-2133gahl 200 55 alleles allele NNS cord-298169-2133gahl 200 56 in in IN cord-298169-2133gahl 200 57 influenza influenza NN cord-298169-2133gahl 200 58 A(H1N1)pdm09 a(h1n1)pdm09 IN cord-298169-2133gahl 200 59 virus virus NN cord-298169-2133gahl 200 60 infected infect VBD cord-298169-2133gahl 200 61 population population NN cord-298169-2133gahl 200 62 of of IN cord-298169-2133gahl 200 63 Assam Assam NNP cord-298169-2133gahl 200 64 , , , cord-298169-2133gahl 200 65 Northeast Northeast NNP cord-298169-2133gahl 200 66 India India NNP cord-298169-2133gahl 200 67 Schizophrenia Schizophrenia NNP cord-298169-2133gahl 200 68 susceptibility susceptibility NN cord-298169-2133gahl 200 69 and and CC cord-298169-2133gahl 200 70 HL HL NNP cord-298169-2133gahl 200 71 - - HYPH cord-298169-2133gahl 200 72 A a DT cord-298169-2133gahl 200 73 antigen antigen NN cord-298169-2133gahl 200 74 The the DT cord-298169-2133gahl 200 75 Clinical Clinical NNP cord-298169-2133gahl 200 76 Challenge Challenge NNP cord-298169-2133gahl 200 77 of of IN cord-298169-2133gahl 200 78 Autoimmune Autoimmune NNP cord-298169-2133gahl 200 79 Psychosis Psychosis NNP cord-298169-2133gahl 200 80 : : : cord-298169-2133gahl 201 1 Learning learn VBG cord-298169-2133gahl 201 2 from from IN cord-298169-2133gahl 201 3 Anti anti JJ cord-298169-2133gahl 201 4 - - JJ cord-298169-2133gahl 201 5 NMDA NMDA NNP cord-298169-2133gahl 201 6 Receptor Receptor NNP cord-298169-2133gahl 201 7 Autoantibodies Autoantibodies NNP cord-298169-2133gahl 201 8 . . . cord-298169-2133gahl 202 1 Front Front NNP cord-298169-2133gahl 202 2 Psychiatry Psychiatry NNP cord-298169-2133gahl 202 3 HLA HLA NNP cord-298169-2133gahl 202 4 - - HYPH cord-298169-2133gahl 202 5 G G NNP cord-298169-2133gahl 203 1 : : : cord-298169-2133gahl 203 2 At at IN cord-298169-2133gahl 203 3 the the DT cord-298169-2133gahl 203 4 Interface Interface NNP cord-298169-2133gahl 203 5 of of IN cord-298169-2133gahl 203 6 Maternal Maternal NNP cord-298169-2133gahl 203 7 - - HYPH cord-298169-2133gahl 203 8 Fetal Fetal NNP cord-298169-2133gahl 203 9 Tolerance tolerance NN cord-298169-2133gahl 203 10 Autoimmune autoimmune JJ cord-298169-2133gahl 203 11 diseases disease NNS cord-298169-2133gahl 203 12 and and CC cord-298169-2133gahl 203 13 8.1 8.1 CD cord-298169-2133gahl 203 14 ancestral ancestral JJ cord-298169-2133gahl 203 15 haplotype haplotype NN cord-298169-2133gahl 203 16 : : : cord-298169-2133gahl 204 1 An an DT cord-298169-2133gahl 204 2 update update NN cord-298169-2133gahl 204 3 . . . cord-298169-2133gahl 205 1 HLA HLA NNP cord-298169-2133gahl 205 2 Classical Classical NNP cord-298169-2133gahl 205 3 Human Human NNP cord-298169-2133gahl 205 4 Leukocyte Leukocyte NNP cord-298169-2133gahl 205 5 Antigen Antigen NNP cord-298169-2133gahl 205 6 Alleles Alleles NNPS cord-298169-2133gahl 205 7 and and CC cord-298169-2133gahl 205 8 C4 C4 NNP cord-298169-2133gahl 205 9 Haplotypes Haplotypes NNP cord-298169-2133gahl 205 10 Are be VBP cord-298169-2133gahl 205 11 Not not RB cord-298169-2133gahl 205 12 Significantly significantly RB cord-298169-2133gahl 205 13 Associated Associated NNP cord-298169-2133gahl 205 14 With with IN cord-298169-2133gahl 205 15 Depression Depression NNP cord-298169-2133gahl 205 16 Regulation regulation NN cord-298169-2133gahl 205 17 of of IN cord-298169-2133gahl 205 18 CNS CNS NNP cord-298169-2133gahl 205 19 synapses synapsis NNS cord-298169-2133gahl 205 20 by by IN cord-298169-2133gahl 205 21 neuronal neuronal JJ cord-298169-2133gahl 205 22 MHC MHC NNP cord-298169-2133gahl 205 23 class class NN cord-298169-2133gahl 205 24 I -PRON- PRP cord-298169-2133gahl 205 25 Identification identification NN cord-298169-2133gahl 205 26 of of IN cord-298169-2133gahl 205 27 common common JJ cord-298169-2133gahl 205 28 genetic genetic JJ cord-298169-2133gahl 205 29 risk risk NN cord-298169-2133gahl 205 30 variants variant NNS cord-298169-2133gahl 205 31 for for IN cord-298169-2133gahl 205 32 autism autism NN cord-298169-2133gahl 205 33 spectrum spectrum NN cord-298169-2133gahl 205 34 disorder disorder NN cord-298169-2133gahl 205 35 HLA HLA NNP cord-298169-2133gahl 205 36 - - HYPH cord-298169-2133gahl 205 37 G G NNP cord-298169-2133gahl 206 1 ( ( -LRB- cord-298169-2133gahl 206 2 * * NFP cord-298169-2133gahl 206 3 ) ) -RRB- cord-298169-2133gahl 206 4 14bp 14bp JJ cord-298169-2133gahl 206 5 insertion insertion NN cord-298169-2133gahl 206 6 / / SYM cord-298169-2133gahl 206 7 deletion deletion NN cord-298169-2133gahl 206 8 polymorphism polymorphism NN cord-298169-2133gahl 206 9 associates associate NNS cord-298169-2133gahl 206 10 with with IN cord-298169-2133gahl 206 11 the the DT cord-298169-2133gahl 206 12 development development NN cord-298169-2133gahl 206 13 of of IN cord-298169-2133gahl 206 14 autistic autistic JJ cord-298169-2133gahl 206 15 spectrum spectrum NN cord-298169-2133gahl 206 16 disorders disorder NNS cord-298169-2133gahl 207 1 HLA HLA NNP cord-298169-2133gahl 207 2 - - HYPH cord-298169-2133gahl 207 3 G G NNP cord-298169-2133gahl 207 4 * * NFP cord-298169-2133gahl 207 5 coding code VBG cord-298169-2133gahl 207 6 region region NN cord-298169-2133gahl 207 7 polymorphism polymorphism NN cord-298169-2133gahl 207 8 is be VBZ cord-298169-2133gahl 207 9 skewed skewed JJ cord-298169-2133gahl 207 10 in in IN cord-298169-2133gahl 207 11 autistic autistic JJ cord-298169-2133gahl 207 12 spectrum spectrum NN cord-298169-2133gahl 207 13 disorders disorder NNS cord-298169-2133gahl 208 1 HLA HLA NNP cord-298169-2133gahl 208 2 - - HYPH cord-298169-2133gahl 208 3 G G NNP cord-298169-2133gahl 208 4 * * NFP cord-298169-2133gahl 208 5 14bp 14bp JJ cord-298169-2133gahl 208 6 Insertion insertion NN cord-298169-2133gahl 208 7 and and CC cord-298169-2133gahl 208 8 the the DT cord-298169-2133gahl 208 9 KIR2DS1-HLAC2 KIR2DS1-HLAC2 NNP cord-298169-2133gahl 208 10 Complex Complex NNP cord-298169-2133gahl 208 11 Impact Impact NNP cord-298169-2133gahl 208 12 on on IN cord-298169-2133gahl 208 13 Behavioral Behavioral NNP cord-298169-2133gahl 208 14 Impairment Impairment NNP cord-298169-2133gahl 208 15 in in IN cord-298169-2133gahl 208 16 Children Children NNP cord-298169-2133gahl 208 17 with with IN cord-298169-2133gahl 208 18 HLA HLA NNP cord-298169-2133gahl 208 19 - - HYPH cord-298169-2133gahl 208 20 G G NNP cord-298169-2133gahl 208 21 allelic allelic JJ cord-298169-2133gahl 208 22 distribution distribution NN cord-298169-2133gahl 208 23 in in IN cord-298169-2133gahl 208 24 Sardinian sardinian JJ cord-298169-2133gahl 208 25 children child NNS cord-298169-2133gahl 208 26 with with IN cord-298169-2133gahl 208 27 Autism Autism NNP cord-298169-2133gahl 208 28 spectrum spectrum NN cord-298169-2133gahl 208 29 disorders disorder NNS cord-298169-2133gahl 208 30 : : : cord-298169-2133gahl 209 1 A a DT cord-298169-2133gahl 209 2 replication replication NN cord-298169-2133gahl 209 3 study study NN cord-298169-2133gahl 209 4 Genetics genetic NNS cord-298169-2133gahl 209 5 of of IN cord-298169-2133gahl 209 6 schizophrenia schizophrenia NN cord-298169-2133gahl 209 7 in in IN cord-298169-2133gahl 209 8 the the DT cord-298169-2133gahl 209 9 South south JJ cord-298169-2133gahl 209 10 African african JJ cord-298169-2133gahl 209 11 Xhosa Xhosa NNP cord-298169-2133gahl 209 12 HERVs herv NNS cord-298169-2133gahl 209 13 , , , cord-298169-2133gahl 209 14 immunity immunity NN cord-298169-2133gahl 209 15 , , , cord-298169-2133gahl 209 16 and and CC cord-298169-2133gahl 209 17 autoimmunity autoimmunity NN cord-298169-2133gahl 209 18 : : : cord-298169-2133gahl 210 1 understanding understand VBG cord-298169-2133gahl 210 2 the the DT cord-298169-2133gahl 210 3 connection connection NN cord-298169-2133gahl 210 4 Genetic genetic JJ cord-298169-2133gahl 210 5 and and CC cord-298169-2133gahl 210 6 environmental environmental JJ cord-298169-2133gahl 210 7 influences influence NNS cord-298169-2133gahl 210 8 on on IN cord-298169-2133gahl 210 9 structural structural JJ cord-298169-2133gahl 210 10 brain brain NN cord-298169-2133gahl 210 11 measures measure NNS cord-298169-2133gahl 210 12 in in IN cord-298169-2133gahl 210 13 twins twin NNS cord-298169-2133gahl 210 14 with with IN cord-298169-2133gahl 210 15 autism autism NN cord-298169-2133gahl 210 16 spectrum spectrum NN cord-298169-2133gahl 210 17 disorder disorder NN cord-298169-2133gahl 210 18 Encephalitis Encephalitis NNP cord-298169-2133gahl 210 19 lethargica lethargica NNP cord-298169-2133gahl 210 20 : : : cord-298169-2133gahl 210 21 100 100 CD cord-298169-2133gahl 210 22 years year NNS cord-298169-2133gahl 210 23 after after IN cord-298169-2133gahl 210 24 the the DT cord-298169-2133gahl 210 25 epidemic epidemic NN cord-298169-2133gahl 210 26 The the DT cord-298169-2133gahl 210 27 Gut Gut NNP cord-298169-2133gahl 210 28 Microbiota Microbiota NNP cord-298169-2133gahl 210 29 and and CC cord-298169-2133gahl 210 30 Dysbiosis Dysbiosis NNP cord-298169-2133gahl 210 31 in in IN cord-298169-2133gahl 210 32 Autism Autism NNP cord-298169-2133gahl 210 33 Spectrum Spectrum NNP cord-298169-2133gahl 210 34 Disorders Disorders NNP cord-298169-2133gahl 210 35 Functional functional JJ cord-298169-2133gahl 210 36 requirement requirement NN cord-298169-2133gahl 210 37 for for IN cord-298169-2133gahl 210 38 class class NN cord-298169-2133gahl 210 39 I -PRON- PRP cord-298169-2133gahl 210 40 MHC MHC NNP cord-298169-2133gahl 210 41 in in IN cord-298169-2133gahl 210 42 CNS CNS NNP cord-298169-2133gahl 210 43 development development NN cord-298169-2133gahl 210 44 and and CC cord-298169-2133gahl 210 45 plasticity plasticity NN cord-298169-2133gahl 210 46 Autoimmune Autoimmune NNP cord-298169-2133gahl 210 47 Diseases Diseases NNPS cord-298169-2133gahl 210 48 and and CC cord-298169-2133gahl 210 49 Psychotic psychotic JJ cord-298169-2133gahl 210 50 Disorders disorder NNS cord-298169-2133gahl 211 1 Dynamic dynamic JJ cord-298169-2133gahl 211 2 disorganization disorganization NN cord-298169-2133gahl 211 3 of of IN cord-298169-2133gahl 211 4 synaptic synaptic JJ cord-298169-2133gahl 211 5 NMDA NMDA NNP cord-298169-2133gahl 211 6 receptors receptor NNS cord-298169-2133gahl 211 7 triggered trigger VBN cord-298169-2133gahl 211 8 by by IN cord-298169-2133gahl 211 9 autoantibodies autoantibody NNS cord-298169-2133gahl 211 10 from from IN cord-298169-2133gahl 211 11 psychotic psychotic JJ cord-298169-2133gahl 211 12 patients patient NNS cord-298169-2133gahl 211 13 Immunopsychiatry Immunopsychiatry NNP cord-298169-2133gahl 211 14 : : : cord-298169-2133gahl 211 15 important important JJ cord-298169-2133gahl 211 16 facts fact NNS cord-298169-2133gahl 212 1 The the DT cord-298169-2133gahl 212 2 HLA HLA NNP cord-298169-2133gahl 212 3 system system NN cord-298169-2133gahl 212 4 Decreased decrease VBD cord-298169-2133gahl 212 5 Cortical Cortical NNP cord-298169-2133gahl 212 6 Thickness Thickness NNP cord-298169-2133gahl 212 7 in in IN cord-298169-2133gahl 212 8 the the DT cord-298169-2133gahl 212 9 Anterior Anterior NNP cord-298169-2133gahl 212 10 Cingulate Cingulate NNP cord-298169-2133gahl 212 11 Cortex Cortex NNP cord-298169-2133gahl 212 12 in in IN cord-298169-2133gahl 212 13 Adults Adults NNPS cord-298169-2133gahl 212 14 with with IN cord-298169-2133gahl 212 15 Autism Autism NNP cord-298169-2133gahl 212 16 Comparative Comparative NNP cord-298169-2133gahl 212 17 genetic genetic JJ cord-298169-2133gahl 212 18 architectures architecture NNS cord-298169-2133gahl 212 19 of of IN cord-298169-2133gahl 212 20 schizophrenia schizophrenia NN cord-298169-2133gahl 212 21 in in IN cord-298169-2133gahl 212 22 East East NNP cord-298169-2133gahl 212 23 Asian asian JJ cord-298169-2133gahl 212 24 and and CC cord-298169-2133gahl 212 25 European european JJ cord-298169-2133gahl 212 26 populations population NNS cord-298169-2133gahl 212 27 Human human JJ cord-298169-2133gahl 212 28 endogenous endogenous JJ cord-298169-2133gahl 212 29 retrovirus retrovirus NN cord-298169-2133gahl 212 30 type type NN cord-298169-2133gahl 212 31 W w NN cord-298169-2133gahl 212 32 ( ( -LRB- cord-298169-2133gahl 212 33 HERV HERV NNP cord-298169-2133gahl 212 34 - - HYPH cord-298169-2133gahl 212 35 W W NNP cord-298169-2133gahl 212 36 ) ) -RRB- cord-298169-2133gahl 212 37 in in IN cord-298169-2133gahl 212 38 schizophrenia schizophrenia NNP cord-298169-2133gahl 212 39 : : : cord-298169-2133gahl 212 40 a a DT cord-298169-2133gahl 212 41 new new JJ cord-298169-2133gahl 212 42 avenue avenue NN cord-298169-2133gahl 212 43 of of IN cord-298169-2133gahl 212 44 research research NN cord-298169-2133gahl 212 45 at at IN cord-298169-2133gahl 212 46 the the DT cord-298169-2133gahl 212 47 gene gene NN cord-298169-2133gahl 212 48 - - HYPH cord-298169-2133gahl 212 49 environment environment NN cord-298169-2133gahl 212 50 interface interface NN cord-298169-2133gahl 213 1 A a DT cord-298169-2133gahl 213 2 double double JJ cord-298169-2133gahl 213 3 amino amino NN cord-298169-2133gahl 213 4 - - HYPH cord-298169-2133gahl 213 5 acid acid NN cord-298169-2133gahl 213 6 change change NN cord-298169-2133gahl 213 7 in in IN cord-298169-2133gahl 213 8 the the DT cord-298169-2133gahl 213 9 HLA HLA NNP cord-298169-2133gahl 213 10 - - HYPH cord-298169-2133gahl 213 11 A a DT cord-298169-2133gahl 213 12 peptide peptide NN cord-298169-2133gahl 213 13 - - HYPH cord-298169-2133gahl 213 14 binding bind VBG cord-298169-2133gahl 213 15 groove groove NN cord-298169-2133gahl 213 16 is be VBZ cord-298169-2133gahl 213 17 associated associate VBN cord-298169-2133gahl 213 18 with with IN cord-298169-2133gahl 213 19 response response NN cord-298169-2133gahl 213 20 to to IN cord-298169-2133gahl 213 21 psychotropic psychotropic JJ cord-298169-2133gahl 213 22 treatment treatment NN cord-298169-2133gahl 213 23 in in IN cord-298169-2133gahl 213 24 patients patient NNS cord-298169-2133gahl 213 25 with with IN cord-298169-2133gahl 213 26 schizophrenia schizophrenia NNP cord-298169-2133gahl 214 1 Structural Structural NNP cord-298169-2133gahl 214 2 Magnetic Magnetic NNP cord-298169-2133gahl 214 3 Resonance Resonance NNP cord-298169-2133gahl 214 4 Imaging Imaging NNP cord-298169-2133gahl 214 5 Demonstrates demonstrate VBZ cord-298169-2133gahl 214 6 Abnormal abnormal JJ cord-298169-2133gahl 214 7 Regionally regionally RB cord-298169-2133gahl 214 8 - - HYPH cord-298169-2133gahl 214 9 Differential differential JJ cord-298169-2133gahl 214 10 Cortical cortical JJ cord-298169-2133gahl 214 11 Thickness thickness NN cord-298169-2133gahl 214 12 Variability variability NN cord-298169-2133gahl 214 13 in in IN cord-298169-2133gahl 214 14 Autism Autism NNP cord-298169-2133gahl 214 15 : : : cord-298169-2133gahl 215 1 From from IN cord-298169-2133gahl 215 2 Newborns newborn NNS cord-298169-2133gahl 215 3 to to IN cord-298169-2133gahl 215 4 Adults Adults NNP cord-298169-2133gahl 215 5 Infectious Infectious NNP cord-298169-2133gahl 215 6 Etiologies Etiologies NNPS cord-298169-2133gahl 215 7 of of IN cord-298169-2133gahl 215 8 Parkinsonism parkinsonism NN cord-298169-2133gahl 215 9 : : : cord-298169-2133gahl 215 10 Pathomechanisms Pathomechanisms NNP cord-298169-2133gahl 215 11 and and CC cord-298169-2133gahl 215 12 Clinical Clinical NNP cord-298169-2133gahl 215 13 Implications implication NNS cord-298169-2133gahl 216 1 The the DT cord-298169-2133gahl 216 2 Role role NN cord-298169-2133gahl 216 3 of of IN cord-298169-2133gahl 216 4 the the DT cord-298169-2133gahl 216 5 Immune Immune NNP cord-298169-2133gahl 216 6 System System NNP cord-298169-2133gahl 216 7 in in IN cord-298169-2133gahl 216 8 Autism Autism NNP cord-298169-2133gahl 216 9 Spectrum Spectrum NNP cord-298169-2133gahl 216 10 Disorder Disorder NNP cord-298169-2133gahl 217 1 The the DT cord-298169-2133gahl 217 2 Major Major NNP cord-298169-2133gahl 217 3 Histocompatibility Histocompatibility NNP cord-298169-2133gahl 217 4 Complex Complex NNP cord-298169-2133gahl 217 5 ( ( -LRB- cord-298169-2133gahl 217 6 MHC MHC NNP cord-298169-2133gahl 217 7 ) ) -RRB- cord-298169-2133gahl 217 8 in in IN cord-298169-2133gahl 217 9 Schizophrenia Schizophrenia NNP cord-298169-2133gahl 217 10 : : : cord-298169-2133gahl 218 1 A a DT cord-298169-2133gahl 218 2 Review Review NNP cord-298169-2133gahl 219 1 How how WRB cord-298169-2133gahl 219 2 the the DT cord-298169-2133gahl 219 3 TCR TCR NNP cord-298169-2133gahl 219 4 balances balance VBZ cord-298169-2133gahl 219 5 sensitivity sensitivity NN cord-298169-2133gahl 219 6 and and CC cord-298169-2133gahl 219 7 specificity specificity NN cord-298169-2133gahl 219 8 for for IN cord-298169-2133gahl 219 9 the the DT cord-298169-2133gahl 219 10 recognition recognition NN cord-298169-2133gahl 219 11 of of IN cord-298169-2133gahl 219 12 self self NN cord-298169-2133gahl 219 13 and and CC cord-298169-2133gahl 219 14 pathogens pathogen NNS cord-298169-2133gahl 219 15 Genetic genetic JJ cord-298169-2133gahl 219 16 predisposition predisposition NN cord-298169-2133gahl 219 17 in in IN cord-298169-2133gahl 219 18 anti anti JJ cord-298169-2133gahl 219 19 - - JJ cord-298169-2133gahl 219 20 LGI1 lgi1 JJ cord-298169-2133gahl 219 21 and and CC cord-298169-2133gahl 219 22 anti anti JJ cord-298169-2133gahl 219 23 - - JJ cord-298169-2133gahl 219 24 NMDA nmda JJ cord-298169-2133gahl 219 25 receptor receptor NN cord-298169-2133gahl 219 26 encephalitis encephalitis NN cord-298169-2133gahl 219 27 Anti Anti NNP cord-298169-2133gahl 219 28 - - JJ cord-298169-2133gahl 219 29 CASPR2 caspr2 JJ cord-298169-2133gahl 219 30 clinical clinical JJ cord-298169-2133gahl 219 31 phenotypes phenotype NNS cord-298169-2133gahl 219 32 correlate correlate VBP cord-298169-2133gahl 219 33 with with IN cord-298169-2133gahl 219 34 HLA HLA NNP cord-298169-2133gahl 219 35 and and CC cord-298169-2133gahl 219 36 immunological immunological JJ cord-298169-2133gahl 219 37 features feature VBZ cord-298169-2133gahl 219 38 Inflammation inflammation NN cord-298169-2133gahl 219 39 and and CC cord-298169-2133gahl 219 40 its -PRON- PRP$ cord-298169-2133gahl 219 41 discontents discontent NNS cord-298169-2133gahl 219 42 : : : cord-298169-2133gahl 219 43 the the DT cord-298169-2133gahl 219 44 role role NN cord-298169-2133gahl 219 45 of of IN cord-298169-2133gahl 219 46 cytokines cytokine NNS cord-298169-2133gahl 219 47 in in IN cord-298169-2133gahl 219 48 the the DT cord-298169-2133gahl 219 49 pathophysiology pathophysiology NN cord-298169-2133gahl 219 50 of of IN cord-298169-2133gahl 219 51 major major JJ cord-298169-2133gahl 219 52 depression depression NN cord-298169-2133gahl 219 53 Involvement Involvement NNP cord-298169-2133gahl 219 54 of of IN cord-298169-2133gahl 219 55 Innate Innate NNP cord-298169-2133gahl 219 56 and and CC cord-298169-2133gahl 219 57 Adaptive Adaptive NNP cord-298169-2133gahl 219 58 Immune Immune NNP cord-298169-2133gahl 219 59 Systems Systems NNPS cord-298169-2133gahl 219 60 Alterations Alterations NNPS cord-298169-2133gahl 219 61 in in IN cord-298169-2133gahl 219 62 the the DT cord-298169-2133gahl 219 63 Pathophysiology Pathophysiology NNP cord-298169-2133gahl 219 64 and and CC cord-298169-2133gahl 219 65 Treatment Treatment NNP cord-298169-2133gahl 219 66 of of IN cord-298169-2133gahl 219 67 Depression Depression NNP cord-298169-2133gahl 219 68 Association Association NNP cord-298169-2133gahl 219 69 of of IN cord-298169-2133gahl 219 70 human human JJ cord-298169-2133gahl 219 71 - - HYPH cord-298169-2133gahl 219 72 leukocyte leukocyte NN cord-298169-2133gahl 219 73 - - HYPH cord-298169-2133gahl 219 74 antigen antigen NN cord-298169-2133gahl 219 75 class class NN cord-298169-2133gahl 220 1 I -PRON- PRP cord-298169-2133gahl 220 2 ( ( -LRB- cord-298169-2133gahl 220 3 B*0703 B*0703 NNP cord-298169-2133gahl 220 4 ) ) -RRB- cord-298169-2133gahl 220 5 and and CC cord-298169-2133gahl 220 6 class class NN cord-298169-2133gahl 220 7 II II NNP cord-298169-2133gahl 220 8 ( ( -LRB- cord-298169-2133gahl 220 9 DRB1 DRB1 NNP cord-298169-2133gahl 220 10 * * NFP cord-298169-2133gahl 220 11 0301 0301 CD cord-298169-2133gahl 220 12 ) ) -RRB- cord-298169-2133gahl 220 13 genotypes genotype NNS cord-298169-2133gahl 220 14 with with IN cord-298169-2133gahl 220 15 susceptibility susceptibility NN cord-298169-2133gahl 220 16 and and CC cord-298169-2133gahl 220 17 resistance resistance NN cord-298169-2133gahl 220 18 to to IN cord-298169-2133gahl 220 19 the the DT cord-298169-2133gahl 220 20 development development NN cord-298169-2133gahl 220 21 of of IN cord-298169-2133gahl 220 22 severe severe JJ cord-298169-2133gahl 220 23 acute acute JJ cord-298169-2133gahl 220 24 respiratory respiratory JJ cord-298169-2133gahl 220 25 syndrome syndrome NN cord-298169-2133gahl 220 26 Human human JJ cord-298169-2133gahl 220 27 leukocyte leukocyte NN cord-298169-2133gahl 220 28 antigen antigen NN cord-298169-2133gahl 220 29 susceptibility susceptibility NN cord-298169-2133gahl 220 30 map map NN cord-298169-2133gahl 220 31 for for IN cord-298169-2133gahl 220 32 SARS SARS NNP cord-298169-2133gahl 220 33 - - HYPH cord-298169-2133gahl 220 34 CoV-2 CoV-2 NNP cord-298169-2133gahl 220 35 Immunity Immunity NNP cord-298169-2133gahl 220 36 and and CC cord-298169-2133gahl 220 37 mental mental JJ cord-298169-2133gahl 220 38 illness illness NN cord-298169-2133gahl 220 39 : : : cord-298169-2133gahl 220 40 findings finding NNS cord-298169-2133gahl 220 41 from from IN cord-298169-2133gahl 220 42 a a DT cord-298169-2133gahl 220 43 Danish danish JJ cord-298169-2133gahl 220 44 population population NN cord-298169-2133gahl 220 45 - - HYPH cord-298169-2133gahl 220 46 based base VBN cord-298169-2133gahl 220 47 immunogenetic immunogenetic JJ cord-298169-2133gahl 220 48 study study NN cord-298169-2133gahl 220 49 of of IN cord-298169-2133gahl 220 50 seven seven CD cord-298169-2133gahl 220 51 psychiatric psychiatric JJ cord-298169-2133gahl 220 52 and and CC cord-298169-2133gahl 220 53 neurodevelopmental neurodevelopmental JJ cord-298169-2133gahl 220 54 disorders disorder NNS cord-298169-2133gahl 220 55 Clozapine Clozapine NNP cord-298169-2133gahl 220 56 Pharmacogenetic Pharmacogenetic NNP cord-298169-2133gahl 220 57 Studies Studies NNPS cord-298169-2133gahl 220 58 in in IN cord-298169-2133gahl 220 59 Schizophrenia Schizophrenia NNP cord-298169-2133gahl 220 60 : : : cord-298169-2133gahl 221 1 Efficacy efficacy NN cord-298169-2133gahl 221 2 and and CC cord-298169-2133gahl 221 3 Agranulocytosis agranulocytosis NN cord-298169-2133gahl 221 4 A a DT cord-298169-2133gahl 221 5 high high JJ cord-298169-2133gahl 221 6 prevalence prevalence NN cord-298169-2133gahl 221 7 of of IN cord-298169-2133gahl 221 8 organ organ NN cord-298169-2133gahl 221 9 - - HYPH cord-298169-2133gahl 221 10 specific specific JJ cord-298169-2133gahl 221 11 autoimmunity autoimmunity NN cord-298169-2133gahl 221 12 in in IN cord-298169-2133gahl 221 13 patients patient NNS cord-298169-2133gahl 221 14 with with IN cord-298169-2133gahl 221 15 bipolar bipolar JJ cord-298169-2133gahl 221 16 disorder disorder NN cord-298169-2133gahl 221 17 Immunoneuropsychiatry Immunoneuropsychiatry NNP cord-298169-2133gahl 221 18 -novel -novel JJ cord-298169-2133gahl 221 19 perspectives perspective NNS cord-298169-2133gahl 221 20 on on IN cord-298169-2133gahl 221 21 brain brain NN cord-298169-2133gahl 221 22 disorders disorder NNS cord-298169-2133gahl 221 23 Differences difference NNS cord-298169-2133gahl 221 24 in in IN cord-298169-2133gahl 221 25 Cortical Cortical NNP cord-298169-2133gahl 221 26 Structure Structure NNP cord-298169-2133gahl 221 27 and and CC cord-298169-2133gahl 221 28 Functional Functional NNP cord-298169-2133gahl 221 29 MRI MRI NNP cord-298169-2133gahl 221 30 Connectivity Connectivity NNP cord-298169-2133gahl 221 31 in in IN cord-298169-2133gahl 221 32 High High NNP cord-298169-2133gahl 221 33 Functioning Functioning NNP cord-298169-2133gahl 221 34 Autism Autism NNP cord-298169-2133gahl 221 35 Molecular molecular JJ cord-298169-2133gahl 221 36 characteristics characteristic NNS cord-298169-2133gahl 221 37 of of IN cord-298169-2133gahl 221 38 Human Human NNP cord-298169-2133gahl 221 39 Endogenous Endogenous NNP cord-298169-2133gahl 221 40 Retrovirus Retrovirus NNP cord-298169-2133gahl 221 41 type type NN cord-298169-2133gahl 221 42 - - : cord-298169-2133gahl 221 43 W w NN cord-298169-2133gahl 221 44 in in IN cord-298169-2133gahl 221 45 schizophrenia schizophrenia NN cord-298169-2133gahl 221 46 and and CC cord-298169-2133gahl 221 47 bipolar bipolar JJ cord-298169-2133gahl 221 48 disorder disorder NN cord-298169-2133gahl 222 1 High high JJ cord-298169-2133gahl 222 2 HLA HLA NNP cord-298169-2133gahl 222 3 - - HYPH cord-298169-2133gahl 222 4 DP DP NNP cord-298169-2133gahl 222 5 Expression expression NN cord-298169-2133gahl 222 6 and and CC cord-298169-2133gahl 222 7 Graft graft NN cord-298169-2133gahl 222 8 - - HYPH cord-298169-2133gahl 222 9 versus versus IN cord-298169-2133gahl 222 10 - - HYPH cord-298169-2133gahl 222 11 Host Host NNP cord-298169-2133gahl 222 12 Disease Disease NNP cord-298169-2133gahl 222 13 Autoimmune Autoimmune NNP cord-298169-2133gahl 222 14 psychosis psychosis NN cord-298169-2133gahl 222 15 : : : cord-298169-2133gahl 222 16 an an DT cord-298169-2133gahl 222 17 international international JJ cord-298169-2133gahl 222 18 consensus consensus NN cord-298169-2133gahl 222 19 on on IN cord-298169-2133gahl 222 20 an an DT cord-298169-2133gahl 222 21 approach approach NN cord-298169-2133gahl 222 22 to to IN cord-298169-2133gahl 222 23 the the DT cord-298169-2133gahl 222 24 diagnosis diagnosis NN cord-298169-2133gahl 222 25 and and CC cord-298169-2133gahl 222 26 management management NN cord-298169-2133gahl 222 27 of of IN cord-298169-2133gahl 222 28 psychosis psychosis NN cord-298169-2133gahl 222 29 of of IN cord-298169-2133gahl 222 30 suspected suspect VBN cord-298169-2133gahl 222 31 autoimmune autoimmune JJ cord-298169-2133gahl 222 32 origin origin NN cord-298169-2133gahl 223 1 The the DT cord-298169-2133gahl 223 2 genetic genetic JJ cord-298169-2133gahl 223 3 basis basis NN cord-298169-2133gahl 223 4 for for IN cord-298169-2133gahl 223 5 the the DT cord-298169-2133gahl 223 6 association association NN cord-298169-2133gahl 223 7 of of IN cord-298169-2133gahl 223 8 the the DT cord-298169-2133gahl 223 9 8.1 8.1 CD cord-298169-2133gahl 223 10 ancestral ancestral JJ cord-298169-2133gahl 223 11 haplotype haplotype NN cord-298169-2133gahl 223 12 ( ( -LRB- cord-298169-2133gahl 223 13 A1 A1 NNP cord-298169-2133gahl 223 14 , , , cord-298169-2133gahl 223 15 B8 B8 NNP cord-298169-2133gahl 223 16 , , , cord-298169-2133gahl 223 17 DR3 DR3 NNP cord-298169-2133gahl 223 18 ) ) -RRB- cord-298169-2133gahl 223 19 with with IN cord-298169-2133gahl 223 20 multiple multiple JJ cord-298169-2133gahl 223 21 immunopathological immunopathological JJ cord-298169-2133gahl 223 22 diseases disease NNS cord-298169-2133gahl 223 23 International International NNP cord-298169-2133gahl 223 24 Schizophrenia Schizophrenia NNP cord-298169-2133gahl 223 25 Consortium Consortium NNP cord-298169-2133gahl 223 26 , , , cord-298169-2133gahl 223 27 Common common JJ cord-298169-2133gahl 223 28 polygenic polygenic JJ cord-298169-2133gahl 223 29 variation variation NN cord-298169-2133gahl 223 30 contributes contribute VBZ cord-298169-2133gahl 223 31 to to IN cord-298169-2133gahl 223 32 risk risk NN cord-298169-2133gahl 223 33 of of IN cord-298169-2133gahl 223 34 schizophrenia schizophrenia NN cord-298169-2133gahl 223 35 and and CC cord-298169-2133gahl 223 36 bipolar bipolar JJ cord-298169-2133gahl 223 37 disorder disorder NN cord-298169-2133gahl 223 38 Soluble soluble JJ cord-298169-2133gahl 223 39 human human JJ cord-298169-2133gahl 223 40 leukocyte leukocyte NN cord-298169-2133gahl 223 41 antigen antigen NN cord-298169-2133gahl 223 42 ( ( -LRB- cord-298169-2133gahl 223 43 sHLA)-G sHLA)-G NNP cord-298169-2133gahl 223 44 levels level NNS cord-298169-2133gahl 223 45 may may MD cord-298169-2133gahl 223 46 predict predict VB cord-298169-2133gahl 223 47 early early JJ cord-298169-2133gahl 223 48 onset onset NN cord-298169-2133gahl 223 49 of of IN cord-298169-2133gahl 223 50 schizophrenia schizophrenia NN cord-298169-2133gahl 223 51 in in IN cord-298169-2133gahl 223 52 male male JJ cord-298169-2133gahl 223 53 patients patient NNS cord-298169-2133gahl 224 1 Elevated elevated JJ cord-298169-2133gahl 224 2 HLA HLA NNP cord-298169-2133gahl 224 3 - - HYPH cord-298169-2133gahl 224 4 A a DT cord-298169-2133gahl 224 5 expression expression NN cord-298169-2133gahl 224 6 impairs impair VBZ cord-298169-2133gahl 224 7 HIV HIV NNP cord-298169-2133gahl 224 8 control control NN cord-298169-2133gahl 224 9 through through IN cord-298169-2133gahl 224 10 inhibition inhibition NN cord-298169-2133gahl 224 11 of of IN cord-298169-2133gahl 224 12 NKG2A NKG2A NNP cord-298169-2133gahl 224 13 - - HYPH cord-298169-2133gahl 224 14 expressing express VBG cord-298169-2133gahl 224 15 cells cell NNS cord-298169-2133gahl 224 16 Schizophrenia Schizophrenia NNP cord-298169-2133gahl 224 17 Working Working NNP cord-298169-2133gahl 224 18 Group Group NNP cord-298169-2133gahl 224 19 of of IN cord-298169-2133gahl 224 20 the the DT cord-298169-2133gahl 224 21 Psychiatric Psychiatric NNP cord-298169-2133gahl 224 22 Genomics Genomics NNPS cord-298169-2133gahl 224 23 Consortium Consortium NNP cord-298169-2133gahl 224 24 Incidence Incidence NNP cord-298169-2133gahl 224 25 of of IN cord-298169-2133gahl 224 26 narcolepsy narcolepsy NN cord-298169-2133gahl 224 27 after after IN cord-298169-2133gahl 224 28 H1N1 H1N1 NNP cord-298169-2133gahl 224 29 influenza influenza NN cord-298169-2133gahl 224 30 and and CC cord-298169-2133gahl 224 31 vaccinations vaccination NNS cord-298169-2133gahl 224 32 : : : cord-298169-2133gahl 225 1 Systematic systematic JJ cord-298169-2133gahl 225 2 review review NN cord-298169-2133gahl 225 3 and and CC cord-298169-2133gahl 225 4 meta meta NNP cord-298169-2133gahl 225 5 - - HYPH cord-298169-2133gahl 225 6 analysis analysis NN cord-298169-2133gahl 225 7 Schizophrenia Schizophrenia NNP cord-298169-2133gahl 225 8 risk risk NN cord-298169-2133gahl 225 9 from from IN cord-298169-2133gahl 225 10 complex complex JJ cord-298169-2133gahl 225 11 variation variation NN cord-298169-2133gahl 225 12 of of IN cord-298169-2133gahl 225 13 complement complement JJ cord-298169-2133gahl 225 14 component component NN cord-298169-2133gahl 226 1 4 4 LS cord-298169-2133gahl 226 2 Pregnancy pregnancy NN cord-298169-2133gahl 226 3 - - HYPH cord-298169-2133gahl 226 4 related relate VBN cord-298169-2133gahl 226 5 immune immune JJ cord-298169-2133gahl 226 6 suppression suppression NN cord-298169-2133gahl 226 7 leads lead VBZ cord-298169-2133gahl 226 8 to to IN cord-298169-2133gahl 226 9 altered alter VBN cord-298169-2133gahl 226 10 influenza influenza NN cord-298169-2133gahl 226 11 vaccine vaccine NN cord-298169-2133gahl 226 12 recall recall NN cord-298169-2133gahl 226 13 responses response NNS cord-298169-2133gahl 227 1 Influence influence NN cord-298169-2133gahl 227 2 of of IN cord-298169-2133gahl 227 3 correlation correlation NN cord-298169-2133gahl 227 4 between between IN cord-298169-2133gahl 227 5 HLA HLA NNP cord-298169-2133gahl 227 6 - - HYPH cord-298169-2133gahl 227 7 G g NN cord-298169-2133gahl 227 8 polymorphism polymorphism NN cord-298169-2133gahl 227 9 and and CC cord-298169-2133gahl 227 10 Interleukin-6 Interleukin-6 NNP cord-298169-2133gahl 227 11 ( ( -LRB- cord-298169-2133gahl 227 12 IL6 il6 NN cord-298169-2133gahl 227 13 ) ) -RRB- cord-298169-2133gahl 227 14 gene gene NN cord-298169-2133gahl 227 15 expression expression NN cord-298169-2133gahl 227 16 on on IN cord-298169-2133gahl 227 17 the the DT cord-298169-2133gahl 227 18 risk risk NN cord-298169-2133gahl 227 19 of of IN cord-298169-2133gahl 227 20 schizophrenia schizophrenia NN cord-298169-2133gahl 227 21 Common common JJ cord-298169-2133gahl 227 22 variants variant NNS cord-298169-2133gahl 227 23 on on IN cord-298169-2133gahl 227 24 chromosome chromosome NN cord-298169-2133gahl 227 25 6p22.1 6p22.1 CD cord-298169-2133gahl 227 26 are be VBP cord-298169-2133gahl 227 27 associated associate VBN cord-298169-2133gahl 227 28 with with IN cord-298169-2133gahl 227 29 schizophrenia schizophrenia NNP cord-298169-2133gahl 227 30 HLA HLA NNP cord-298169-2133gahl 227 31 class class NN cord-298169-2133gahl 227 32 II II NNP cord-298169-2133gahl 227 33 allele allele NN cord-298169-2133gahl 228 1 DRB1 DRB1 NNP cord-298169-2133gahl 228 2 * * NFP cord-298169-2133gahl 228 3 16:02 16:02 CD cord-298169-2133gahl 228 4 is be VBZ cord-298169-2133gahl 228 5 associated associate VBN cord-298169-2133gahl 228 6 with with IN cord-298169-2133gahl 228 7 anti anti JJ cord-298169-2133gahl 228 8 - - JJ cord-298169-2133gahl 228 9 NMDAR NMDAR NNP cord-298169-2133gahl 228 10 encephalitis encephalitis NN cord-298169-2133gahl 228 11 Genome Genome NNP cord-298169-2133gahl 228 12 - - HYPH cord-298169-2133gahl 228 13 wide wide JJ cord-298169-2133gahl 228 14 association association NN cord-298169-2133gahl 228 15 study study NN cord-298169-2133gahl 228 16 identifies identify VBZ cord-298169-2133gahl 228 17 30 30 CD cord-298169-2133gahl 228 18 loci locus NNS cord-298169-2133gahl 228 19 associated associate VBN cord-298169-2133gahl 228 20 with with IN cord-298169-2133gahl 228 21 bipolar bipolar JJ cord-298169-2133gahl 228 22 disorder disorder NN cord-298169-2133gahl 229 1 Common common JJ cord-298169-2133gahl 229 2 variants variant NNS cord-298169-2133gahl 229 3 conferring confer VBG cord-298169-2133gahl 229 4 risk risk NN cord-298169-2133gahl 229 5 of of IN cord-298169-2133gahl 229 6 schizophrenia schizophrenia NN cord-298169-2133gahl 229 7 Dynamic dynamic JJ cord-298169-2133gahl 229 8 gene gene NN cord-298169-2133gahl 229 9 expression expression NN cord-298169-2133gahl 229 10 in in IN cord-298169-2133gahl 229 11 the the DT cord-298169-2133gahl 229 12 human human JJ cord-298169-2133gahl 229 13 cerebral cerebral JJ cord-298169-2133gahl 229 14 cortex cortex NN cord-298169-2133gahl 229 15 distinguishes distinguish VBZ cord-298169-2133gahl 229 16 children child NNS cord-298169-2133gahl 229 17 from from IN cord-298169-2133gahl 229 18 adults adult NNS cord-298169-2133gahl 230 1 The the DT cord-298169-2133gahl 230 2 HLA HLA NNP cord-298169-2133gahl 230 3 - - HYPH cord-298169-2133gahl 230 4 G G NNP cord-298169-2133gahl 230 5 Genetic Genetic NNP cord-298169-2133gahl 230 6 Contribution Contribution NNP cord-298169-2133gahl 230 7 to to IN cord-298169-2133gahl 230 8 Bipolar Bipolar NNP cord-298169-2133gahl 230 9 Disorder Disorder NNP cord-298169-2133gahl 230 10 : : : cord-298169-2133gahl 231 1 A a DT cord-298169-2133gahl 231 2 Trans Trans NNP cord-298169-2133gahl 231 3 - - NNP cord-298169-2133gahl 231 4 Ethnic ethnic JJ cord-298169-2133gahl 231 5 Replication Replication NNP cord-298169-2133gahl 231 6 HLA HLA NNP cord-298169-2133gahl 231 7 Polymorphism polymorphism NN cord-298169-2133gahl 231 8 in in IN cord-298169-2133gahl 231 9 Regressive regressive JJ cord-298169-2133gahl 231 10 and and CC cord-298169-2133gahl 231 11 Non non JJ cord-298169-2133gahl 231 12 - - JJ cord-298169-2133gahl 231 13 Regressive regressive JJ cord-298169-2133gahl 231 14 Autism Autism NNP cord-298169-2133gahl 231 15 : : : cord-298169-2133gahl 231 16 A a DT cord-298169-2133gahl 231 17 Preliminary Preliminary NNP cord-298169-2133gahl 231 18 Study study NN cord-298169-2133gahl 232 1 The the DT cord-298169-2133gahl 232 2 HLA HLA NNP cord-298169-2133gahl 232 3 8.1 8.1 CD cord-298169-2133gahl 232 4 ancestral ancestral JJ cord-298169-2133gahl 232 5 haplotype haplotype NN cord-298169-2133gahl 232 6 in in IN cord-298169-2133gahl 232 7 schizophrenia schizophrenia NNP cord-298169-2133gahl 232 8 : : : cord-298169-2133gahl 232 9 dual dual JJ cord-298169-2133gahl 232 10 implication implication NN cord-298169-2133gahl 232 11 in in IN cord-298169-2133gahl 232 12 neuro neuro JJ cord-298169-2133gahl 232 13 - - HYPH cord-298169-2133gahl 232 14 synaptic synaptic JJ cord-298169-2133gahl 232 15 pruning pruning NN cord-298169-2133gahl 232 16 and and CC cord-298169-2133gahl 232 17 autoimmunity autoimmunity NN cord-298169-2133gahl 232 18 ? ? . cord-298169-2133gahl 233 1 HLA HLA NNP cord-298169-2133gahl 233 2 genetics genetic NNS cord-298169-2133gahl 233 3 in in IN cord-298169-2133gahl 233 4 bipolar bipolar JJ cord-298169-2133gahl 233 5 disorder disorder NN cord-298169-2133gahl 233 6 HLA HLA NNP cord-298169-2133gahl 233 7 - - HYPH cord-298169-2133gahl 233 8 C C NNP cord-298169-2133gahl 233 9 cell cell NN cord-298169-2133gahl 233 10 surface surface NN cord-298169-2133gahl 233 11 expression expression NN cord-298169-2133gahl 233 12 and and CC cord-298169-2133gahl 233 13 control control NN cord-298169-2133gahl 233 14 of of IN cord-298169-2133gahl 233 15 HIV HIV NNP cord-298169-2133gahl 233 16 / / SYM cord-298169-2133gahl 233 17 AIDS AIDS NNP cord-298169-2133gahl 233 18 correlate correlate VBP cord-298169-2133gahl 233 19 with with IN cord-298169-2133gahl 233 20 a a DT cord-298169-2133gahl 233 21 variant variant NN cord-298169-2133gahl 233 22 upstream upstream NN cord-298169-2133gahl 233 23 of of IN cord-298169-2133gahl 233 24 HLA HLA NNP cord-298169-2133gahl 233 25 - - HYPH cord-298169-2133gahl 233 26 C C NNP cord-298169-2133gahl 233 27 Major Major NNP cord-298169-2133gahl 233 28 histocompatibility histocompatibility NN cord-298169-2133gahl 233 29 complex complex JJ cord-298169-2133gahl 233 30 genomics genomic NNS cord-298169-2133gahl 233 31 and and CC cord-298169-2133gahl 233 32 human human JJ cord-298169-2133gahl 233 33 disease disease NN cord-298169-2133gahl 233 34 Anti Anti NNP cord-298169-2133gahl 233 35 - - NNP cord-298169-2133gahl 233 36 NMDA nmda JJ cord-298169-2133gahl 233 37 - - HYPH cord-298169-2133gahl 233 38 receptor receptor NN cord-298169-2133gahl 233 39 encephalitis encephalitis NN cord-298169-2133gahl 233 40 in in IN cord-298169-2133gahl 233 41 a a DT cord-298169-2133gahl 233 42 3 3 CD cord-298169-2133gahl 233 43 year year NN cord-298169-2133gahl 233 44 old old JJ cord-298169-2133gahl 233 45 patient patient NN cord-298169-2133gahl 233 46 with with IN cord-298169-2133gahl 233 47 chromosome chromosome NN cord-298169-2133gahl 233 48 6p21.32 6p21.32 NN cord-298169-2133gahl 233 49 microdeletion microdeletion NN cord-298169-2133gahl 233 50 including include VBG cord-298169-2133gahl 233 51 the the DT cord-298169-2133gahl 233 52 HLA HLA NNP cord-298169-2133gahl 233 53 cluster cluster NN cord-298169-2133gahl 233 54 Emerging Emerging NNP cord-298169-2133gahl 233 55 Roles Roles NNP cord-298169-2133gahl 233 56 for for IN cord-298169-2133gahl 233 57 the the DT cord-298169-2133gahl 233 58 Gut Gut NNP cord-298169-2133gahl 233 59 Microbiome Microbiome NNP cord-298169-2133gahl 233 60 in in IN cord-298169-2133gahl 233 61 New new JJ cord-298169-2133gahl 233 62 insights insight NNS cord-298169-2133gahl 233 63 into into IN cord-298169-2133gahl 233 64 the the DT cord-298169-2133gahl 233 65 genetic genetic JJ cord-298169-2133gahl 233 66 mechanism mechanism NN cord-298169-2133gahl 233 67 of of IN cord-298169-2133gahl 233 68 IQ IQ NNP cord-298169-2133gahl 233 69 in in IN cord-298169-2133gahl 233 70 autism autism NN cord-298169-2133gahl 233 71 spectrum spectrum NN cord-298169-2133gahl 233 72 disorders disorder NNS cord-298169-2133gahl 234 1 Human human JJ cord-298169-2133gahl 234 2 - - HYPH cord-298169-2133gahl 234 3 leukocyte leukocyte NN cord-298169-2133gahl 234 4 antigen antigen NN cord-298169-2133gahl 234 5 class class NN cord-298169-2133gahl 235 1 I -PRON- PRP cord-298169-2133gahl 235 2 Cw Cw NNP cord-298169-2133gahl 235 3 1502 1502 CD cord-298169-2133gahl 235 4 and and CC cord-298169-2133gahl 236 1 class class NN cord-298169-2133gahl 236 2 II II NNP cord-298169-2133gahl 236 3 DR DR NNP cord-298169-2133gahl 236 4 0301 0301 CD cord-298169-2133gahl 236 5 genotypes genotype NNS cord-298169-2133gahl 236 6 are be VBP cord-298169-2133gahl 236 7 associated associate VBN cord-298169-2133gahl 236 8 with with IN cord-298169-2133gahl 236 9 resistance resistance NN cord-298169-2133gahl 236 10 to to IN cord-298169-2133gahl 236 11 severe severe JJ cord-298169-2133gahl 236 12 acute acute JJ cord-298169-2133gahl 236 13 respiratory respiratory JJ cord-298169-2133gahl 236 14 syndrome syndrome NN cord-298169-2133gahl 236 15 ( ( -LRB- cord-298169-2133gahl 236 16 SARS SARS NNP cord-298169-2133gahl 236 17 ) ) -RRB- cord-298169-2133gahl 236 18 infection infection NN cord-298169-2133gahl 237 1 Common common JJ cord-298169-2133gahl 237 2 HLA HLA NNP cord-298169-2133gahl 237 3 - - HYPH cord-298169-2133gahl 237 4 B8-DR3 B8-DR3 NNP cord-298169-2133gahl 237 5 haplotype haplotype NN cord-298169-2133gahl 237 6 in in IN cord-298169-2133gahl 237 7 Northern Northern NNP cord-298169-2133gahl 237 8 India India NNP cord-298169-2133gahl 237 9 is be VBZ cord-298169-2133gahl 237 10 different different JJ cord-298169-2133gahl 237 11 from from IN cord-298169-2133gahl 237 12 that that DT cord-298169-2133gahl 237 13 found find VBN cord-298169-2133gahl 237 14 in in IN cord-298169-2133gahl 237 15 Europe Europe NNP cord-298169-2133gahl 237 16 Sequence Sequence NNP cord-298169-2133gahl 237 17 analysis analysis NN cord-298169-2133gahl 237 18 of of IN cord-298169-2133gahl 237 19 T t NN cord-298169-2133gahl 237 20 - - HYPH cord-298169-2133gahl 237 21 cell cell NN cord-298169-2133gahl 237 22 repertoires repertoire NNS cord-298169-2133gahl 237 23 in in IN cord-298169-2133gahl 237 24 health health NN cord-298169-2133gahl 237 25 and and CC cord-298169-2133gahl 237 26 disease disease NN cord-298169-2133gahl 237 27 Structural structural JJ cord-298169-2133gahl 237 28 basis basis NN cord-298169-2133gahl 237 29 for for IN cord-298169-2133gahl 237 30 self self NN cord-298169-2133gahl 237 31 - - HYPH cord-298169-2133gahl 237 32 recognition recognition NN cord-298169-2133gahl 237 33 by by IN cord-298169-2133gahl 237 34 autoimmune autoimmune JJ cord-298169-2133gahl 237 35 T t NN cord-298169-2133gahl 237 36 - - HYPH cord-298169-2133gahl 237 37 cell cell NN cord-298169-2133gahl 237 38 receptors receptor NNS cord-298169-2133gahl 237 39 Contracting contract VBG cord-298169-2133gahl 237 40 schizophrenia schizophrenia NN cord-298169-2133gahl 237 41 : : : cord-298169-2133gahl 237 42 lessons lesson NNS cord-298169-2133gahl 237 43 from from IN cord-298169-2133gahl 237 44 the the DT cord-298169-2133gahl 237 45 influenza influenza NN cord-298169-2133gahl 237 46 epidemic epidemic NN cord-298169-2133gahl 237 47 of of IN cord-298169-2133gahl 237 48 1918 1918 CD cord-298169-2133gahl 237 49 - - SYM cord-298169-2133gahl 237 50 1919 1919 CD