id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-004670-k1om7prn	Barthold, S. W.	Olfactory neural pathway in mouse hepatitis virus nasoencephalitis	1988		.txt	text/plain	1963	117	48	The mechanism of brain infection with mouse hepatitis virus-JHM was studied in BALB/cByJ mice following intranasal inoculation, and found to be a consequence of direct viral spread along olfactory nerves into olfactory bulbs of the brain. Lesions, antigen and virus were observed in the olfactory bulb and anterior brain as early as 2 days and posterior brain by 4 days after inoculation. The purpose of this study was to determine the route of virus entry into brain by examination of the sequential progression of infection with neurotropic MHV-JHM following i.n. inoculation of mice. To confirm that brain infection resulted from direct extension of virus along olfactory nerves and not due to viremia, groups of five mice were inoculated either i.n. or p.o. with MHV-JHM. Sequential studies of lesion, antigen and virus distribution in nose and brain indicated anterior to posterior progression of infection.	./cache/cord-004670-k1om7prn.txt	./txt/cord-004670-k1om7prn.txt