id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-256149-btjq84q7	Duhalde-Vega, Maite	The peptide specificities of the autoantibodies elicited by mouse hepatitis virus A59	2006-10-31		.txt	text/plain	3590	172	58	Synthetic decapeptides (N = 206) covering the entire sequence of mouse liver fumarylacetoacetate hydrolase (FAH) were used to analyze the specificities of the autoantibodies (autoAb) elicited towards this enzyme in mice infected with mouse hepatitis virus (MHV). Results indicated that the induction of the autoAb is not only related to molecular or structural mimicry, but rather supports the Danger model, in which any aggression, in this case the MHV infection, is susceptible to trigger the production of autoAb. Mouse hepatitis virus strain A59 (MHV-A59) is a coronavirus that triggers various pathologies in susceptible mice, including hepatitis and thymus involution, IgG2a-restricted hypergammaglobulinaemia and transient demyelination [1, 2] . Overlapping decapeptides corresponding to the entire mouse FAH sequence were prepared using the PEPSCAN method and their reactivities with sera from MHV-infected mice at different times was determined by ELISA. Results indicated that various regions of the enzyme, including sequence 1e20, are recognized as soon as 15 days after infection and that the autoimmune response is not restricted to peptides homologous to viral proteins.	./cache/cord-256149-btjq84q7.txt	./txt/cord-256149-btjq84q7.txt