id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-304954-5b4yji8n	Yamaguchi, Kenjiro	Production of mice from a lethal coronavirus infection in the central nervous system by adoptive transfer of virus-specific T cell clones	1991-04-30		.txt	text/plain	3955	209	58	title: Production of mice from a lethal coronavirus infection in the central nervous system by adoptive transfer of virus-specific T cell clones Abstract The protective effect of a mouse hepatitis virus type-4 (MHV-4)-specific CD8+ cytotoxic T cell clone and a CD4+ helper T cell clone was examined by the adoptive transfer into brains of mice lethally infected with MHV-4. Although the adoptive transfer of both types of the T cell clones suppressed viral growth and viral antigen-positive cells in the brains, a significant inhibition of virus replication by the cytotoxic T cell clone was detected prior to that induced by the helper T cell clone. In the present study we demonstrate that the adoptive transfer of virus-specific CD8 ÷ CTL clones also protects mice from a lethal MHV-4 infection. In this study we have confirmed that the adoptive transfer of virus-specific CD4 + Th cells protects mice from a MHV-4 lethal infection.	./cache/cord-304954-5b4yji8n.txt	./txt/cord-304954-5b4yji8n.txt