id sid tid token lemma pos cord-348746-yaf61cmx 1 1 key key JJ cord-348746-yaf61cmx 1 2 : : : cord-348746-yaf61cmx 1 3 cord-348746-yaf61cmx cord-348746-yaf61cmx NN cord-348746-yaf61cmx 1 4 authors author NNS cord-348746-yaf61cmx 1 5 : : : cord-348746-yaf61cmx 1 6 Foley Foley NNP cord-348746-yaf61cmx 1 7 , , , cord-348746-yaf61cmx 1 8 Janet Janet NNP cord-348746-yaf61cmx 1 9 E. E. NNP cord-348746-yaf61cmx 1 10 ; ; : cord-348746-yaf61cmx 1 11 Leutenegger Leutenegger NNP cord-348746-yaf61cmx 1 12 , , , cord-348746-yaf61cmx 1 13 Christian christian JJ cord-348746-yaf61cmx 1 14 title title NN cord-348746-yaf61cmx 1 15 : : : cord-348746-yaf61cmx 1 16 A a DT cord-348746-yaf61cmx 1 17 Review Review NNP cord-348746-yaf61cmx 1 18 of of IN cord-348746-yaf61cmx 1 19 Coronavirus Coronavirus NNP cord-348746-yaf61cmx 1 20 Infection Infection NNP cord-348746-yaf61cmx 1 21 in in IN cord-348746-yaf61cmx 1 22 the the DT cord-348746-yaf61cmx 1 23 Central Central NNP cord-348746-yaf61cmx 1 24 Nervous Nervous NNP cord-348746-yaf61cmx 1 25 System System NNP cord-348746-yaf61cmx 1 26 of of IN cord-348746-yaf61cmx 1 27 Cats Cats NNPS cord-348746-yaf61cmx 1 28 and and CC cord-348746-yaf61cmx 1 29 Mice Mice NNP cord-348746-yaf61cmx 1 30 date date NN cord-348746-yaf61cmx 1 31 : : : cord-348746-yaf61cmx 1 32 2008 2008 CD cord-348746-yaf61cmx 1 33 - - SYM cord-348746-yaf61cmx 1 34 06 06 CD cord-348746-yaf61cmx 1 35 - - HYPH cord-348746-yaf61cmx 1 36 28 28 CD cord-348746-yaf61cmx 1 37 journal journal NN cord-348746-yaf61cmx 1 38 : : : cord-348746-yaf61cmx 1 39 J J NNP cord-348746-yaf61cmx 1 40 Vet Vet NNP cord-348746-yaf61cmx 1 41 Intern Intern NNP cord-348746-yaf61cmx 1 42 Med Med NNP cord-348746-yaf61cmx 1 43 DOI doi NN cord-348746-yaf61cmx 1 44 : : : cord-348746-yaf61cmx 2 1 10.1111 10.1111 CD cord-348746-yaf61cmx 2 2 / / SYM cord-348746-yaf61cmx 2 3 j.1939 j.1939 NN cord-348746-yaf61cmx 2 4 - - HYPH cord-348746-yaf61cmx 2 5 1676.2001.tb01572.x 1676.2001.tb01572.x CD cord-348746-yaf61cmx 2 6 sha sha NNP cord-348746-yaf61cmx 2 7 : : : cord-348746-yaf61cmx 2 8 4860f7eda428bce3a48d404200e9cca3c2786645 4860f7eda428bce3a48d404200e9cca3c2786645 CD cord-348746-yaf61cmx 2 9 doc_id doc_id CD cord-348746-yaf61cmx 2 10 : : : cord-348746-yaf61cmx 2 11 348746 348746 CD cord-348746-yaf61cmx 2 12 cord_uid cord_uid NNS cord-348746-yaf61cmx 2 13 : : : cord-348746-yaf61cmx 3 1 yaf61cmx yaf61cmx JJ cord-348746-yaf61cmx 3 2 Feline feline JJ cord-348746-yaf61cmx 3 3 infectious infectious JJ cord-348746-yaf61cmx 3 4 peritonitis peritonitis NN cord-348746-yaf61cmx 3 5 ( ( -LRB- cord-348746-yaf61cmx 3 6 FIP FIP NNP cord-348746-yaf61cmx 3 7 ) ) -RRB- cord-348746-yaf61cmx 3 8 is be VBZ cord-348746-yaf61cmx 3 9 a a DT cord-348746-yaf61cmx 3 10 common common JJ cord-348746-yaf61cmx 3 11 cause cause NN cord-348746-yaf61cmx 3 12 of of IN cord-348746-yaf61cmx 3 13 death death NN cord-348746-yaf61cmx 3 14 in in IN cord-348746-yaf61cmx 3 15 cats cat NNS cord-348746-yaf61cmx 3 16 . . . cord-348746-yaf61cmx 4 1 Management management NN cord-348746-yaf61cmx 4 2 of of IN cord-348746-yaf61cmx 4 3 this this DT cord-348746-yaf61cmx 4 4 disease disease NN cord-348746-yaf61cmx 4 5 has have VBZ cord-348746-yaf61cmx 4 6 been be VBN cord-348746-yaf61cmx 4 7 hampered hamper VBN cord-348746-yaf61cmx 4 8 by by IN cord-348746-yaf61cmx 4 9 difficulties difficulty NNS cord-348746-yaf61cmx 4 10 identifying identify VBG cord-348746-yaf61cmx 4 11 the the DT cord-348746-yaf61cmx 4 12 infection infection NN cord-348746-yaf61cmx 4 13 and and CC cord-348746-yaf61cmx 4 14 determining determine VBG cord-348746-yaf61cmx 4 15 the the DT cord-348746-yaf61cmx 4 16 immunological immunological JJ cord-348746-yaf61cmx 4 17 status status NN cord-348746-yaf61cmx 4 18 of of IN cord-348746-yaf61cmx 4 19 affected affected JJ cord-348746-yaf61cmx 4 20 cats cat NNS cord-348746-yaf61cmx 4 21 and and CC cord-348746-yaf61cmx 4 22 by by IN cord-348746-yaf61cmx 4 23 high high JJ cord-348746-yaf61cmx 4 24 variability variability NN cord-348746-yaf61cmx 4 25 in in IN cord-348746-yaf61cmx 4 26 the the DT cord-348746-yaf61cmx 4 27 clinical clinical JJ cord-348746-yaf61cmx 4 28 , , , cord-348746-yaf61cmx 4 29 pathological pathological JJ cord-348746-yaf61cmx 4 30 , , , cord-348746-yaf61cmx 4 31 and and CC cord-348746-yaf61cmx 4 32 immunological immunological JJ cord-348746-yaf61cmx 4 33 characteristics characteristic NNS cord-348746-yaf61cmx 4 34 of of IN cord-348746-yaf61cmx 4 35 affected affect VBN cord-348746-yaf61cmx 4 36 cats cat NNS cord-348746-yaf61cmx 4 37 . . . cord-348746-yaf61cmx 5 1 Neurological neurological JJ cord-348746-yaf61cmx 5 2 FIP FIP NNP cord-348746-yaf61cmx 5 3 , , , cord-348746-yaf61cmx 5 4 which which WDT cord-348746-yaf61cmx 5 5 is be VBZ cord-348746-yaf61cmx 5 6 much much RB cord-348746-yaf61cmx 5 7 more more RBR cord-348746-yaf61cmx 5 8 homogeneous homogeneous JJ cord-348746-yaf61cmx 5 9 than than IN cord-348746-yaf61cmx 5 10 systemic systemic JJ cord-348746-yaf61cmx 5 11 effusive effusive JJ cord-348746-yaf61cmx 5 12 or or CC cord-348746-yaf61cmx 5 13 noneffusive noneffusive JJ cord-348746-yaf61cmx 5 14 FIP fip NN cord-348746-yaf61cmx 5 15 , , , cord-348746-yaf61cmx 5 16 appears appear VBZ cord-348746-yaf61cmx 5 17 to to TO cord-348746-yaf61cmx 5 18 be be VB cord-348746-yaf61cmx 5 19 a a DT cord-348746-yaf61cmx 5 20 good good JJ cord-348746-yaf61cmx 5 21 model model NN cord-348746-yaf61cmx 5 22 for for IN cord-348746-yaf61cmx 5 23 establishing establish VBG cord-348746-yaf61cmx 5 24 the the DT cord-348746-yaf61cmx 5 25 basic basic JJ cord-348746-yaf61cmx 5 26 features feature NNS cord-348746-yaf61cmx 5 27 of of IN cord-348746-yaf61cmx 5 28 FIP FIP NNP cord-348746-yaf61cmx 5 29 immunopathogenesis immunopathogenesis NN cord-348746-yaf61cmx 5 30 . . . cord-348746-yaf61cmx 6 1 Very very RB cord-348746-yaf61cmx 6 2 little little JJ cord-348746-yaf61cmx 6 3 information information NN cord-348746-yaf61cmx 6 4 is be VBZ cord-348746-yaf61cmx 6 5 available available JJ cord-348746-yaf61cmx 6 6 about about IN cord-348746-yaf61cmx 6 7 the the DT cord-348746-yaf61cmx 6 8 immunopathogenesis immunopathogenesis NN cord-348746-yaf61cmx 6 9 of of IN cord-348746-yaf61cmx 6 10 neurologic neurologic JJ cord-348746-yaf61cmx 6 11 FIP FIP NNP cord-348746-yaf61cmx 6 12 , , , cord-348746-yaf61cmx 6 13 and and CC cord-348746-yaf61cmx 6 14 it -PRON- PRP cord-348746-yaf61cmx 6 15 is be VBZ cord-348746-yaf61cmx 6 16 reasonable reasonable JJ cord-348746-yaf61cmx 6 17 to to TO cord-348746-yaf61cmx 6 18 use use VB cord-348746-yaf61cmx 6 19 research research NN cord-348746-yaf61cmx 6 20 from from IN cord-348746-yaf61cmx 6 21 the the DT cord-348746-yaf61cmx 6 22 well‐characterized well‐characterized JJ cord-348746-yaf61cmx 6 23 mouse mouse NN cord-348746-yaf61cmx 6 24 hepatitis hepatitis NN cord-348746-yaf61cmx 6 25 virus virus NN cord-348746-yaf61cmx 6 26 ( ( -LRB- cord-348746-yaf61cmx 6 27 MHV MHV NNP cord-348746-yaf61cmx 6 28 ) ) -RRB- cord-348746-yaf61cmx 6 29 immune‐mediated immune‐mediate VBN cord-348746-yaf61cmx 6 30 encephalitis encephalitis NN cord-348746-yaf61cmx 6 31 system system NN cord-348746-yaf61cmx 6 32 , , , cord-348746-yaf61cmx 6 33 as as IN cord-348746-yaf61cmx 6 34 a a DT cord-348746-yaf61cmx 6 35 template template NN cord-348746-yaf61cmx 6 36 for for IN cord-348746-yaf61cmx 6 37 FIP FIP NNP cord-348746-yaf61cmx 6 38 investigation investigation NN cord-348746-yaf61cmx 6 39 , , , cord-348746-yaf61cmx 6 40 and and CC cord-348746-yaf61cmx 6 41 to to TO cord-348746-yaf61cmx 6 42 contrast contrast VB cord-348746-yaf61cmx 6 43 findings finding NNS cord-348746-yaf61cmx 6 44 from from IN cord-348746-yaf61cmx 6 45 the the DT cord-348746-yaf61cmx 6 46 MHV MHV NNP cord-348746-yaf61cmx 6 47 model model NN cord-348746-yaf61cmx 6 48 with with IN cord-348746-yaf61cmx 6 49 those those DT cord-348746-yaf61cmx 6 50 of of IN cord-348746-yaf61cmx 6 51 FIP FIP NNP cord-348746-yaf61cmx 6 52 . . . cord-348746-yaf61cmx 7 1 It -PRON- PRP cord-348746-yaf61cmx 7 2 is be VBZ cord-348746-yaf61cmx 7 3 expected expect VBN cord-348746-yaf61cmx 7 4 that that IN cord-348746-yaf61cmx 7 5 the the DT cord-348746-yaf61cmx 7 6 immunopathogenic immunopathogenic JJ cord-348746-yaf61cmx 7 7 mechanisms mechanism NNS cord-348746-yaf61cmx 7 8 will will MD cord-348746-yaf61cmx 7 9 have have VB cord-348746-yaf61cmx 7 10 important important JJ cord-348746-yaf61cmx 7 11 similarities similarity NNS cord-348746-yaf61cmx 7 12 . . . cord-348746-yaf61cmx 8 1 Such such JJ cord-348746-yaf61cmx 8 2 comparative comparative JJ cord-348746-yaf61cmx 8 3 research research NN cord-348746-yaf61cmx 8 4 may may MD cord-348746-yaf61cmx 8 5 lead lead VB cord-348746-yaf61cmx 8 6 to to IN cord-348746-yaf61cmx 8 7 better well JJR cord-348746-yaf61cmx 8 8 understanding understanding NN cord-348746-yaf61cmx 8 9 of of IN cord-348746-yaf61cmx 8 10 FIP FIP NNP cord-348746-yaf61cmx 8 11 immunopathogenesis immunopathogenesis NN cord-348746-yaf61cmx 8 12 and and CC cord-348746-yaf61cmx 8 13 rational rational JJ cord-348746-yaf61cmx 8 14 prospects prospect NNS cord-348746-yaf61cmx 8 15 for for IN cord-348746-yaf61cmx 8 16 management management NN cord-348746-yaf61cmx 8 17 of of IN cord-348746-yaf61cmx 8 18 this this DT cord-348746-yaf61cmx 8 19 frustrating frustrating JJ cord-348746-yaf61cmx 8 20 disease disease NN cord-348746-yaf61cmx 8 21 . . . cord-348746-yaf61cmx 9 1 F F NNP cord-348746-yaf61cmx 9 2 eline eline NNP cord-348746-yaf61cmx 9 3 infectious infectious JJ cord-348746-yaf61cmx 9 4 peritonitis peritonitis NN cord-348746-yaf61cmx 9 5 ( ( -LRB- cord-348746-yaf61cmx 9 6 FIP FIP NNP cord-348746-yaf61cmx 9 7 ) ) -RRB- cord-348746-yaf61cmx 9 8 is be VBZ cord-348746-yaf61cmx 9 9 a a DT cord-348746-yaf61cmx 9 10 fatal fatal JJ cord-348746-yaf61cmx 9 11 , , , cord-348746-yaf61cmx 9 12 immune immune JJ cord-348746-yaf61cmx 9 13 - - HYPH cord-348746-yaf61cmx 9 14 mediated mediate VBN cord-348746-yaf61cmx 9 15 disease disease NN cord-348746-yaf61cmx 9 16 produced produce VBN cord-348746-yaf61cmx 9 17 as as IN cord-348746-yaf61cmx 9 18 a a DT cord-348746-yaf61cmx 9 19 result result NN cord-348746-yaf61cmx 9 20 of of IN cord-348746-yaf61cmx 9 21 infection infection NN cord-348746-yaf61cmx 9 22 of of IN cord-348746-yaf61cmx 9 23 macrophages macrophage NNS cord-348746-yaf61cmx 9 24 by by IN cord-348746-yaf61cmx 9 25 mutant mutant JJ cord-348746-yaf61cmx 9 26 feline feline JJ cord-348746-yaf61cmx 9 27 coronavirus coronavirus NN cord-348746-yaf61cmx 9 28 strains strain NNS cord-348746-yaf61cmx 9 29 ( ( -LRB- cord-348746-yaf61cmx 9 30 FIPVs fipv NNS cord-348746-yaf61cmx 9 31 ) ) -RRB- cord-348746-yaf61cmx 9 32 . . . cord-348746-yaf61cmx 10 1 The the DT cord-348746-yaf61cmx 10 2 severity severity NN cord-348746-yaf61cmx 10 3 of of IN cord-348746-yaf61cmx 10 4 FIP FIP NNP cord-348746-yaf61cmx 10 5 is be VBZ cord-348746-yaf61cmx 10 6 determined determine VBN cord-348746-yaf61cmx 10 7 by by IN cord-348746-yaf61cmx 10 8 virus virus NN cord-348746-yaf61cmx 10 9 strain strain NN cord-348746-yaf61cmx 10 10 and and CC cord-348746-yaf61cmx 10 11 by by IN cord-348746-yaf61cmx 10 12 host host NN cord-348746-yaf61cmx 10 13 - - HYPH cord-348746-yaf61cmx 10 14 specific specific JJ cord-348746-yaf61cmx 10 15 , , , cord-348746-yaf61cmx 10 16 partially partially RB cord-348746-yaf61cmx 10 17 heritable heritable JJ cord-348746-yaf61cmx 10 18 immune immune JJ cord-348746-yaf61cmx 10 19 responses response NNS cord-348746-yaf61cmx 10 20 . . . cord-348746-yaf61cmx 11 1 1 1 LS cord-348746-yaf61cmx 12 1 The the DT cord-348746-yaf61cmx 12 2 causative causative JJ cord-348746-yaf61cmx 12 3 agent agent NN cord-348746-yaf61cmx 12 4 , , , cord-348746-yaf61cmx 12 5 FIP FIP NNP cord-348746-yaf61cmx 12 6 virus virus NN cord-348746-yaf61cmx 12 7 ( ( -LRB- cord-348746-yaf61cmx 12 8 FIPV FIPV NNP cord-348746-yaf61cmx 12 9 ) ) -RRB- cord-348746-yaf61cmx 12 10 , , , cord-348746-yaf61cmx 12 11 is be VBZ cord-348746-yaf61cmx 12 12 a a DT cord-348746-yaf61cmx 12 13 macrophage macrophage NN cord-348746-yaf61cmx 12 14 - - HYPH cord-348746-yaf61cmx 12 15 tropic tropic NN cord-348746-yaf61cmx 12 16 mutant mutant NN cord-348746-yaf61cmx 12 17 of of IN cord-348746-yaf61cmx 12 18 the the DT cord-348746-yaf61cmx 12 19 ubiquitous ubiquitous JJ cord-348746-yaf61cmx 12 20 feline feline JJ cord-348746-yaf61cmx 12 21 enteric enteric JJ cord-348746-yaf61cmx 12 22 coronavirus coronavirus NN cord-348746-yaf61cmx 12 23 ( ( -LRB- cord-348746-yaf61cmx 12 24 FECV FECV NNP cord-348746-yaf61cmx 12 25 ) ) -RRB- cord-348746-yaf61cmx 12 26 . . . cord-348746-yaf61cmx 13 1 [ [ -LRB- cord-348746-yaf61cmx 13 2 2 2 LS cord-348746-yaf61cmx 13 3 ] ] -RRB- cord-348746-yaf61cmx 13 4 [ [ -LRB- cord-348746-yaf61cmx 13 5 3 3 CD cord-348746-yaf61cmx 13 6 ] ] -RRB- cord-348746-yaf61cmx 13 7 [ [ -LRB- cord-348746-yaf61cmx 13 8 4 4 CD cord-348746-yaf61cmx 13 9 ] ] -RRB- cord-348746-yaf61cmx 14 1 These these DT cord-348746-yaf61cmx 14 2 feline feline JJ cord-348746-yaf61cmx 14 3 coronaviruses coronaviruse NNS cord-348746-yaf61cmx 14 4 are be VBP cord-348746-yaf61cmx 14 5 closely closely RB cord-348746-yaf61cmx 14 6 related relate VBN cord-348746-yaf61cmx 14 7 to to IN cord-348746-yaf61cmx 14 8 transmissible transmissible JJ cord-348746-yaf61cmx 14 9 gastroenteritis gastroenteritis NN cord-348746-yaf61cmx 14 10 virus virus NN cord-348746-yaf61cmx 14 11 ( ( -LRB- cord-348746-yaf61cmx 14 12 TGEV TGEV NNP cord-348746-yaf61cmx 14 13 ) ) -RRB- cord-348746-yaf61cmx 14 14 of of IN cord-348746-yaf61cmx 14 15 pigs pig NNS cord-348746-yaf61cmx 14 16 and and CC cord-348746-yaf61cmx 14 17 more more RBR cord-348746-yaf61cmx 14 18 distantly distantly RB cord-348746-yaf61cmx 14 19 related related JJ cord-348746-yaf61cmx 14 20 to to IN cord-348746-yaf61cmx 14 21 MHV MHV NNP cord-348746-yaf61cmx 14 22 ( ( -LRB- cord-348746-yaf61cmx 14 23 a a DT cord-348746-yaf61cmx 14 24 coronavirus coronavirus NN cord-348746-yaf61cmx 14 25 of of IN cord-348746-yaf61cmx 14 26 rodents rodent NNS cord-348746-yaf61cmx 14 27 ) ) -RRB- cord-348746-yaf61cmx 14 28 , , , cord-348746-yaf61cmx 14 29 human human JJ cord-348746-yaf61cmx 14 30 respiratory respiratory JJ cord-348746-yaf61cmx 14 31 coronavirus coronavirus NN cord-348746-yaf61cmx 14 32 , , , cord-348746-yaf61cmx 14 33 and and CC cord-348746-yaf61cmx 14 34 others other NNS cord-348746-yaf61cmx 14 35 . . . cord-348746-yaf61cmx 15 1 As as IN cord-348746-yaf61cmx 15 2 with with IN cord-348746-yaf61cmx 15 3 most most JJS cord-348746-yaf61cmx 15 4 RNA RNA NNP cord-348746-yaf61cmx 15 5 viruses virus NNS cord-348746-yaf61cmx 15 6 , , , cord-348746-yaf61cmx 15 7 a a DT cord-348746-yaf61cmx 15 8 high high JJ cord-348746-yaf61cmx 15 9 rate rate NN cord-348746-yaf61cmx 15 10 of of IN cord-348746-yaf61cmx 15 11 point point NN cord-348746-yaf61cmx 15 12 or or CC cord-348746-yaf61cmx 15 13 other other JJ cord-348746-yaf61cmx 15 14 small small JJ cord-348746-yaf61cmx 15 15 - - HYPH cord-348746-yaf61cmx 15 16 scale scale NN cord-348746-yaf61cmx 15 17 mutations mutation NNS cord-348746-yaf61cmx 15 18 and and CC cord-348746-yaf61cmx 15 19 larger large JJR cord-348746-yaf61cmx 15 20 scale scale NN cord-348746-yaf61cmx 15 21 recombination recombination NN cord-348746-yaf61cmx 15 22 events event NNS cord-348746-yaf61cmx 15 23 occur occur VBP cord-348746-yaf61cmx 15 24 . . . cord-348746-yaf61cmx 16 1 Type Type NNP cord-348746-yaf61cmx 16 2 II II NNP cord-348746-yaf61cmx 16 3 FECVs fecv NNS cord-348746-yaf61cmx 16 4 are be VBP cord-348746-yaf61cmx 16 5 viruses virus NNS cord-348746-yaf61cmx 16 6 that that WDT cord-348746-yaf61cmx 16 7 arise arise VBP cord-348746-yaf61cmx 16 8 as as IN cord-348746-yaf61cmx 16 9 a a DT cord-348746-yaf61cmx 16 10 result result NN cord-348746-yaf61cmx 16 11 of of IN cord-348746-yaf61cmx 16 12 recombinations recombination NNS cord-348746-yaf61cmx 16 13 between between IN cord-348746-yaf61cmx 16 14 type type NN cord-348746-yaf61cmx 16 15 I -PRON- PRP cord-348746-yaf61cmx 16 16 FECV FECV NNP cord-348746-yaf61cmx 16 17 and and CC cord-348746-yaf61cmx 16 18 canine canine JJ cord-348746-yaf61cmx 16 19 coronavirus coronavirus NN cord-348746-yaf61cmx 16 20 ( ( -LRB- cord-348746-yaf61cmx 16 21 CCV CCV NNP cord-348746-yaf61cmx 16 22 ) ) -RRB- cord-348746-yaf61cmx 16 23 . . . cord-348746-yaf61cmx 17 1 Type Type NNP cord-348746-yaf61cmx 17 2 II II NNP cord-348746-yaf61cmx 17 3 FECVs fecv NNS cord-348746-yaf61cmx 17 4 acquired acquire VBD cord-348746-yaf61cmx 17 5 a a DT cord-348746-yaf61cmx 17 6 canine canine JJ cord-348746-yaf61cmx 17 7 S S NNP cord-348746-yaf61cmx 17 8 gene gene NN cord-348746-yaf61cmx 17 9 and and CC cord-348746-yaf61cmx 17 10 express express VB cord-348746-yaf61cmx 17 11 a a DT cord-348746-yaf61cmx 17 12 canine canine JJ cord-348746-yaf61cmx 17 13 S S NNP cord-348746-yaf61cmx 17 14 gene gene NN cord-348746-yaf61cmx 17 15 product product NN cord-348746-yaf61cmx 17 16 . . . cord-348746-yaf61cmx 18 1 5 5 LS cord-348746-yaf61cmx 19 1 Mutations mutation NNS cord-348746-yaf61cmx 19 2 are be VBP cord-348746-yaf61cmx 19 3 common common JJ cord-348746-yaf61cmx 19 4 in in IN cord-348746-yaf61cmx 19 5 the the DT cord-348746-yaf61cmx 19 6 7b 7b CD cord-348746-yaf61cmx 19 7 open open JJ cord-348746-yaf61cmx 19 8 reading reading NN cord-348746-yaf61cmx 19 9 frame frame NN cord-348746-yaf61cmx 19 10 ( ( -LRB- cord-348746-yaf61cmx 19 11 ORF ORF NNP cord-348746-yaf61cmx 19 12 ) ) -RRB- cord-348746-yaf61cmx 19 13 of of IN cord-348746-yaf61cmx 19 14 both both DT cord-348746-yaf61cmx 19 15 type type NN cord-348746-yaf61cmx 19 16 I -PRON- PRP cord-348746-yaf61cmx 19 17 and and CC cord-348746-yaf61cmx 19 18 type type NN cord-348746-yaf61cmx 19 19 II ii CD cord-348746-yaf61cmx 19 20 FECVs fecv NNS cord-348746-yaf61cmx 19 21 and and CC cord-348746-yaf61cmx 19 22 may may MD cord-348746-yaf61cmx 19 23 be be VB cord-348746-yaf61cmx 19 24 associated associate VBN cord-348746-yaf61cmx 19 25 with with IN cord-348746-yaf61cmx 19 26 reduced reduce VBN cord-348746-yaf61cmx 19 27 virulence virulence NN cord-348746-yaf61cmx 19 28 . . . cord-348746-yaf61cmx 20 1 4 4 LS cord-348746-yaf61cmx 20 2 , , , cord-348746-yaf61cmx 20 3 6 6 CD cord-348746-yaf61cmx 21 1 The the DT cord-348746-yaf61cmx 21 2 7b 7b JJ cord-348746-yaf61cmx 21 3 ORF ORF NNP cord-348746-yaf61cmx 21 4 arose arise VBD cord-348746-yaf61cmx 21 5 in in IN cord-348746-yaf61cmx 21 6 the the DT cord-348746-yaf61cmx 21 7 FECV FECV NNP cord-348746-yaf61cmx 21 8 / / SYM cord-348746-yaf61cmx 21 9 CCV ccv NN cord-348746-yaf61cmx 21 10 lineage lineage NN cord-348746-yaf61cmx 21 11 and and CC cord-348746-yaf61cmx 21 12 encodes encode VBZ cord-348746-yaf61cmx 21 13 a a DT cord-348746-yaf61cmx 21 14 nonstructural nonstructural JJ cord-348746-yaf61cmx 21 15 secretory secretory JJ cord-348746-yaf61cmx 21 16 glycoprotein glycoprotein NN cord-348746-yaf61cmx 21 17 of of IN cord-348746-yaf61cmx 21 18 undetermined undetermined JJ cord-348746-yaf61cmx 21 19 function function NN cord-348746-yaf61cmx 21 20 , , , cord-348746-yaf61cmx 21 21 which which WDT cord-348746-yaf61cmx 21 22 is be VBZ cord-348746-yaf61cmx 21 23 not not RB cord-348746-yaf61cmx 21 24 necessary necessary JJ cord-348746-yaf61cmx 21 25 for for IN cord-348746-yaf61cmx 21 26 viral viral JJ cord-348746-yaf61cmx 21 27 replication replication NN cord-348746-yaf61cmx 21 28 . . . cord-348746-yaf61cmx 22 1 7 7 CD cord-348746-yaf61cmx 22 2 Deletions deletion NNS cord-348746-yaf61cmx 22 3 , , , cord-348746-yaf61cmx 22 4 point point NN cord-348746-yaf61cmx 22 5 mutations mutation NNS cord-348746-yaf61cmx 22 6 , , , cord-348746-yaf61cmx 22 7 and and CC cord-348746-yaf61cmx 22 8 frame frame NN cord-348746-yaf61cmx 22 9 - - HYPH cord-348746-yaf61cmx 22 10 shift shift NN cord-348746-yaf61cmx 22 11 mutations mutation NNS cord-348746-yaf61cmx 22 12 leading lead VBG cord-348746-yaf61cmx 22 13 to to IN cord-348746-yaf61cmx 22 14 early early JJ cord-348746-yaf61cmx 22 15 truncation truncation NN cord-348746-yaf61cmx 22 16 of of IN cord-348746-yaf61cmx 22 17 the the DT cord-348746-yaf61cmx 22 18 3c 3c NNP cord-348746-yaf61cmx 22 19 ORF ORF NNP cord-348746-yaf61cmx 22 20 also also RB cord-348746-yaf61cmx 22 21 are be VBP cord-348746-yaf61cmx 22 22 common common JJ cord-348746-yaf61cmx 22 23 . . . cord-348746-yaf61cmx 23 1 4 4 LS cord-348746-yaf61cmx 23 2 , , , cord-348746-yaf61cmx 23 3 6 6 CD cord-348746-yaf61cmx 24 1 Because because IN cord-348746-yaf61cmx 24 2 FIP fip NN cord-348746-yaf61cmx 24 3 - - HYPH cord-348746-yaf61cmx 24 4 defining define VBG cord-348746-yaf61cmx 24 5 mutations mutation NNS cord-348746-yaf61cmx 24 6 may may MD cord-348746-yaf61cmx 24 7 occur occur VB cord-348746-yaf61cmx 24 8 in in IN cord-348746-yaf61cmx 24 9 the the DT cord-348746-yaf61cmx 24 10 S S NNP cord-348746-yaf61cmx 24 11 , , , cord-348746-yaf61cmx 24 12 3c 3c NNP cord-348746-yaf61cmx 24 13 , , , cord-348746-yaf61cmx 24 14 and and CC cord-348746-yaf61cmx 24 15 7b 7b JJ cord-348746-yaf61cmx 24 16 genes gene NNS cord-348746-yaf61cmx 24 17 , , , cord-348746-yaf61cmx 24 18 polymerase polymerase NN cord-348746-yaf61cmx 24 19 chain chain NN cord-348746-yaf61cmx 24 20 reaction reaction NN cord-348746-yaf61cmx 24 21 ( ( -LRB- cord-348746-yaf61cmx 24 22 PCR PCR NNP cord-348746-yaf61cmx 24 23 ) ) -RRB- cord-348746-yaf61cmx 24 24 with with IN cord-348746-yaf61cmx 24 25 these these DT cord-348746-yaf61cmx 24 26 genes gene NNS cord-348746-yaf61cmx 24 27 as as IN cord-348746-yaf61cmx 24 28 a a DT cord-348746-yaf61cmx 24 29 target target NN cord-348746-yaf61cmx 24 30 can can MD cord-348746-yaf61cmx 24 31 not not RB cord-348746-yaf61cmx 24 32 discriminate discriminate VB cord-348746-yaf61cmx 24 33 between between IN cord-348746-yaf61cmx 24 34 benign benign JJ cord-348746-yaf61cmx 24 35 FECV FECV NNP cord-348746-yaf61cmx 24 36 and and CC cord-348746-yaf61cmx 24 37 fatal fatal JJ cord-348746-yaf61cmx 24 38 FIPV FIPV NNS cord-348746-yaf61cmx 24 39 . . . cord-348746-yaf61cmx 25 1 [ [ -LRB- cord-348746-yaf61cmx 25 2 2 2 LS cord-348746-yaf61cmx 25 3 ] ] -RRB- cord-348746-yaf61cmx 25 4 [ [ -LRB- cord-348746-yaf61cmx 25 5 3 3 CD cord-348746-yaf61cmx 25 6 ] ] -RRB- cord-348746-yaf61cmx 25 7 [ [ -LRB- cord-348746-yaf61cmx 25 8 4 4 CD cord-348746-yaf61cmx 25 9 ] ] -RRB- cord-348746-yaf61cmx 26 1 Murine murine JJ cord-348746-yaf61cmx 26 2 hepatitis hepatitis NN cord-348746-yaf61cmx 26 3 virus virus NN cord-348746-yaf61cmx 26 4 shares share VBZ cord-348746-yaf61cmx 26 5 most most JJS cord-348746-yaf61cmx 26 6 genes gene NNS cord-348746-yaf61cmx 26 7 with with IN cord-348746-yaf61cmx 26 8 the the DT cord-348746-yaf61cmx 26 9 FECVs fecv NNS cord-348746-yaf61cmx 26 10 , , , cord-348746-yaf61cmx 26 11 including include VBG cord-348746-yaf61cmx 26 12 M M NNP cord-348746-yaf61cmx 26 13 ( ( -LRB- cord-348746-yaf61cmx 26 14 membrane membrane NN cord-348746-yaf61cmx 26 15 glycoprotein glycoprotein NN cord-348746-yaf61cmx 26 16 ) ) -RRB- cord-348746-yaf61cmx 26 17 , , , cord-348746-yaf61cmx 26 18 E E NNP cord-348746-yaf61cmx 26 19 ( ( -LRB- cord-348746-yaf61cmx 26 20 small small JJ cord-348746-yaf61cmx 26 21 membrane membrane NN cord-348746-yaf61cmx 26 22 ) ) -RRB- cord-348746-yaf61cmx 26 23 , , , cord-348746-yaf61cmx 26 24 N N NNP cord-348746-yaf61cmx 26 25 ( ( -LRB- cord-348746-yaf61cmx 26 26 nucleocapsid nucleocapsid NN cord-348746-yaf61cmx 26 27 ) ) -RRB- cord-348746-yaf61cmx 26 28 , , , cord-348746-yaf61cmx 26 29 and and CC cord-348746-yaf61cmx 26 30 S S NNP cord-348746-yaf61cmx 26 31 ( ( -LRB- cord-348746-yaf61cmx 26 32 spike spike NN cord-348746-yaf61cmx 26 33 glycoprotein glycoprotein NN cord-348746-yaf61cmx 26 34 ) ) -RRB- cord-348746-yaf61cmx 26 35 , , , cord-348746-yaf61cmx 26 36 which which WDT cord-348746-yaf61cmx 26 37 is be VBZ cord-348746-yaf61cmx 26 38 post post JJ cord-348746-yaf61cmx 26 39 - - JJ cord-348746-yaf61cmx 26 40 translationally translationally RB cord-348746-yaf61cmx 26 41 modified modify VBN cord-348746-yaf61cmx 26 42 to to IN cord-348746-yaf61cmx 26 43 S1 S1 NNP cord-348746-yaf61cmx 26 44 and and CC cord-348746-yaf61cmx 26 45 S2 S2 NNP cord-348746-yaf61cmx 26 46 . . . cord-348746-yaf61cmx 27 1 8 8 CD cord-348746-yaf61cmx 28 1 The the DT cord-348746-yaf61cmx 28 2 MHV MHV NNP cord-348746-yaf61cmx 28 3 genome genome NN cord-348746-yaf61cmx 28 4 , , , cord-348746-yaf61cmx 28 5 however however RB cord-348746-yaf61cmx 28 6 , , , cord-348746-yaf61cmx 28 7 also also RB cord-348746-yaf61cmx 28 8 codes code VBZ cord-348746-yaf61cmx 28 9 for for IN cord-348746-yaf61cmx 28 10 an an DT cord-348746-yaf61cmx 28 11 HE HE NNP cord-348746-yaf61cmx 28 12 protein protein NN cord-348746-yaf61cmx 28 13 and and CC cord-348746-yaf61cmx 28 14 does do VBZ cord-348746-yaf61cmx 28 15 not not RB cord-348746-yaf61cmx 28 16 contain contain VB cord-348746-yaf61cmx 28 17 a a DT cord-348746-yaf61cmx 28 18 7b 7b JJ cord-348746-yaf61cmx 28 19 ORF ORF NNP cord-348746-yaf61cmx 28 20 . . . cord-348746-yaf61cmx 29 1 Mutations mutation NNS cord-348746-yaf61cmx 29 2 in in IN cord-348746-yaf61cmx 29 3 the the DT cord-348746-yaf61cmx 29 4 E e NN cord-348746-yaf61cmx 29 5 and and CC cord-348746-yaf61cmx 29 6 S S NNP cord-348746-yaf61cmx 29 7 proteins protein NNS cord-348746-yaf61cmx 29 8 lead lead VBP cord-348746-yaf61cmx 29 9 to to IN cord-348746-yaf61cmx 29 10 attenuation attenuation NN cord-348746-yaf61cmx 29 11 of of IN cord-348746-yaf61cmx 29 12 MHV MHV NNP cord-348746-yaf61cmx 29 13 . . . cord-348746-yaf61cmx 30 1 9 9 CD cord-348746-yaf61cmx 31 1 A a DT cord-348746-yaf61cmx 31 2 third third JJ cord-348746-yaf61cmx 31 3 coronavirus coronavirus NN cord-348746-yaf61cmx 31 4 , , , cord-348746-yaf61cmx 31 5 HCV-229E HCV-229E NNP cord-348746-yaf61cmx 31 6 , , , cord-348746-yaf61cmx 31 7 has have VBZ cord-348746-yaf61cmx 31 8 been be VBN cord-348746-yaf61cmx 31 9 implicated implicate VBN cord-348746-yaf61cmx 31 10 in in IN cord-348746-yaf61cmx 31 11 neurological neurological JJ cord-348746-yaf61cmx 31 12 disease disease NN cord-348746-yaf61cmx 31 13 in in IN cord-348746-yaf61cmx 31 14 people people NNS cord-348746-yaf61cmx 31 15 . . . cord-348746-yaf61cmx 32 1 10 10 CD cord-348746-yaf61cmx 32 2 _SP cord-348746-yaf61cmx 32 3 FIP FIP NNP cord-348746-yaf61cmx 32 4 occurs occur VBZ cord-348746-yaf61cmx 32 5 most most RBS cord-348746-yaf61cmx 32 6 frequently frequently RB cord-348746-yaf61cmx 32 7 in in IN cord-348746-yaf61cmx 32 8 cats cat NNS cord-348746-yaf61cmx 32 9 younger young JJR cord-348746-yaf61cmx 32 10 than than IN cord-348746-yaf61cmx 32 11 3 3 CD cord-348746-yaf61cmx 32 12 years year NNS cord-348746-yaf61cmx 32 13 of of IN cord-348746-yaf61cmx 32 14 age age NN cord-348746-yaf61cmx 32 15 from from IN cord-348746-yaf61cmx 32 16 multiple multiple JJ cord-348746-yaf61cmx 32 17 - - HYPH cord-348746-yaf61cmx 32 18 cat cat NN cord-348746-yaf61cmx 32 19 homes home NNS cord-348746-yaf61cmx 32 20 ( ( -LRB- cord-348746-yaf61cmx 32 21 shelters shelter NNS cord-348746-yaf61cmx 32 22 and and CC cord-348746-yaf61cmx 32 23 breeding breeding NN cord-348746-yaf61cmx 32 24 catteries catteries NNP cord-348746-yaf61cmx 32 25 ) ) -RRB- cord-348746-yaf61cmx 32 26 . . . cord-348746-yaf61cmx 33 1 11 11 CD cord-348746-yaf61cmx 33 2 , , , cord-348746-yaf61cmx 33 3 12 12 CD cord-348746-yaf61cmx 33 4 One one CD cord-348746-yaf61cmx 33 5 - - HYPH cord-348746-yaf61cmx 33 6 quarter quarter NN cord-348746-yaf61cmx 33 7 to to IN cord-348746-yaf61cmx 33 8 one one CD cord-348746-yaf61cmx 33 9 - - HYPH cord-348746-yaf61cmx 33 10 third third NN cord-348746-yaf61cmx 33 11 of of IN cord-348746-yaf61cmx 33 12 cats cat NNS cord-348746-yaf61cmx 33 13 with with IN cord-348746-yaf61cmx 33 14 noneffusive noneffusive JJ cord-348746-yaf61cmx 33 15 FIP FIP NNP cord-348746-yaf61cmx 33 16 have have VBP cord-348746-yaf61cmx 33 17 either either CC cord-348746-yaf61cmx 33 18 primary primary JJ cord-348746-yaf61cmx 33 19 neurological neurological JJ cord-348746-yaf61cmx 33 20 FIP fip NN cord-348746-yaf61cmx 33 21 or or CC cord-348746-yaf61cmx 33 22 neurological neurological JJ cord-348746-yaf61cmx 33 23 abnormalities abnormality NNS cord-348746-yaf61cmx 33 24 as as IN cord-348746-yaf61cmx 33 25 a a DT cord-348746-yaf61cmx 33 26 part part NN cord-348746-yaf61cmx 33 27 of of IN cord-348746-yaf61cmx 33 28 their -PRON- PRP$ cord-348746-yaf61cmx 33 29 overall overall JJ cord-348746-yaf61cmx 33 30 disease disease NN cord-348746-yaf61cmx 33 31 presentation presentation NN cord-348746-yaf61cmx 33 32 ( ( -LRB- cord-348746-yaf61cmx 33 33 Foley Foley NNP cord-348746-yaf61cmx 33 34 and and CC cord-348746-yaf61cmx 33 35 Pedersen Pedersen NNP cord-348746-yaf61cmx 33 36 , , , cord-348746-yaf61cmx 33 37 unpublished unpublished JJ cord-348746-yaf61cmx 33 38 data datum NNS cord-348746-yaf61cmx 33 39 ) ) -RRB- cord-348746-yaf61cmx 33 40 . . . cord-348746-yaf61cmx 34 1 13 13 CD cord-348746-yaf61cmx 35 1 The the DT cord-348746-yaf61cmx 35 2 immunological immunological JJ cord-348746-yaf61cmx 35 3 and and CC cord-348746-yaf61cmx 35 4 pathological pathological JJ cord-348746-yaf61cmx 35 5 characteristics characteristic NNS cord-348746-yaf61cmx 35 6 of of IN cord-348746-yaf61cmx 35 7 neurological neurological JJ cord-348746-yaf61cmx 35 8 FIP fip NN cord-348746-yaf61cmx 35 9 , , , cord-348746-yaf61cmx 35 10 however however RB cord-348746-yaf61cmx 35 11 , , , cord-348746-yaf61cmx 35 12 are be VBP cord-348746-yaf61cmx 35 13 much much RB cord-348746-yaf61cmx 35 14 more more RBR cord-348746-yaf61cmx 35 15 stereotypic stereotypic JJ cord-348746-yaf61cmx 35 16 than than IN cord-348746-yaf61cmx 35 17 those those DT cord-348746-yaf61cmx 35 18 of of IN cord-348746-yaf61cmx 35 19 systemic systemic JJ cord-348746-yaf61cmx 35 20 FIP fip NN cord-348746-yaf61cmx 35 21 . . . cord-348746-yaf61cmx 36 1 Thus thus RB cord-348746-yaf61cmx 36 2 , , , cord-348746-yaf61cmx 36 3 neurological neurological JJ cord-348746-yaf61cmx 36 4 FIP fip NN cord-348746-yaf61cmx 36 5 may may MD cord-348746-yaf61cmx 36 6 be be VB cord-348746-yaf61cmx 36 7 useful useful JJ cord-348746-yaf61cmx 36 8 for for IN cord-348746-yaf61cmx 36 9 studying study VBG cord-348746-yaf61cmx 36 10 basic basic JJ cord-348746-yaf61cmx 36 11 mechanisms mechanism NNS cord-348746-yaf61cmx 36 12 of of IN cord-348746-yaf61cmx 36 13 FIP fip NN cord-348746-yaf61cmx 36 14 pathogenesis pathogenesis NN cord-348746-yaf61cmx 36 15 . . . cord-348746-yaf61cmx 37 1 The the DT cord-348746-yaf61cmx 37 2 extent extent NN cord-348746-yaf61cmx 37 3 to to TO cord-348746-yaf61cmx 37 4 which which WDT cord-348746-yaf61cmx 37 5 genetic genetic JJ cord-348746-yaf61cmx 37 6 differences difference NNS cord-348746-yaf61cmx 37 7 among among IN cord-348746-yaf61cmx 37 8 viral viral JJ cord-348746-yaf61cmx 37 9 strains strain NNS cord-348746-yaf61cmx 37 10 confer confer VBP cord-348746-yaf61cmx 37 11 relative relative JJ cord-348746-yaf61cmx 37 12 neurotropism neurotropism NN cord-348746-yaf61cmx 37 13 is be VBZ cord-348746-yaf61cmx 37 14 unknown unknown JJ cord-348746-yaf61cmx 37 15 , , , cord-348746-yaf61cmx 37 16 but but CC cord-348746-yaf61cmx 37 17 some some DT cord-348746-yaf61cmx 37 18 cats cat NNS cord-348746-yaf61cmx 37 19 with with IN cord-348746-yaf61cmx 37 20 severe severe JJ cord-348746-yaf61cmx 37 21 neurological neurological JJ cord-348746-yaf61cmx 37 22 disease disease NN cord-348746-yaf61cmx 37 23 have have VBP cord-348746-yaf61cmx 37 24 mild mild JJ cord-348746-yaf61cmx 37 25 or or CC cord-348746-yaf61cmx 37 26 undetectable undetectable JJ cord-348746-yaf61cmx 37 27 systemic systemic JJ cord-348746-yaf61cmx 37 28 disease disease NN cord-348746-yaf61cmx 37 29 . . . cord-348746-yaf61cmx 38 1 Both both DT cord-348746-yaf61cmx 38 2 neurological neurological JJ cord-348746-yaf61cmx 38 3 and and CC cord-348746-yaf61cmx 38 4 generalized generalized JJ cord-348746-yaf61cmx 38 5 FIP FIP NNP cord-348746-yaf61cmx 38 6 may may MD cord-348746-yaf61cmx 38 7 present present VB cord-348746-yaf61cmx 38 8 first first RB cord-348746-yaf61cmx 38 9 as as IN cord-348746-yaf61cmx 38 10 a a DT cord-348746-yaf61cmx 38 11 nonspecific nonspecific JJ cord-348746-yaf61cmx 38 12 illness illness NN cord-348746-yaf61cmx 38 13 , , , cord-348746-yaf61cmx 38 14 with with IN cord-348746-yaf61cmx 38 15 clinical clinical JJ cord-348746-yaf61cmx 38 16 signs sign NNS cord-348746-yaf61cmx 38 17 including include VBG cord-348746-yaf61cmx 38 18 weight weight NN cord-348746-yaf61cmx 38 19 loss loss NN cord-348746-yaf61cmx 38 20 , , , cord-348746-yaf61cmx 38 21 weakness weakness NN cord-348746-yaf61cmx 38 22 , , , cord-348746-yaf61cmx 38 23 fever fever NN cord-348746-yaf61cmx 38 24 , , , cord-348746-yaf61cmx 38 25 and and CC cord-348746-yaf61cmx 38 26 lethargy lethargy NN cord-348746-yaf61cmx 38 27 . . . cord-348746-yaf61cmx 39 1 Abdominal abdominal JJ cord-348746-yaf61cmx 39 2 abnormalities abnormality NNS cord-348746-yaf61cmx 39 3 are be VBP cord-348746-yaf61cmx 39 4 detected detect VBN cord-348746-yaf61cmx 39 5 commonly commonly RB cord-348746-yaf61cmx 39 6 on on IN cord-348746-yaf61cmx 39 7 physical physical JJ cord-348746-yaf61cmx 39 8 examination examination NN cord-348746-yaf61cmx 39 9 of of IN cord-348746-yaf61cmx 39 10 cats cat NNS cord-348746-yaf61cmx 39 11 with with IN cord-348746-yaf61cmx 39 12 neurological neurological JJ cord-348746-yaf61cmx 39 13 FIP fip NN cord-348746-yaf61cmx 39 14 , , , cord-348746-yaf61cmx 39 15 including include VBG cord-348746-yaf61cmx 39 16 mesenteric mesenteric JJ cord-348746-yaf61cmx 39 17 lymphadenopathy lymphadenopathy JJ cord-348746-yaf61cmx 39 18 and and CC cord-348746-yaf61cmx 39 19 irregular irregular JJ cord-348746-yaf61cmx 39 20 splenic splenic JJ cord-348746-yaf61cmx 39 21 and and CC cord-348746-yaf61cmx 39 22 renal renal JJ cord-348746-yaf61cmx 39 23 surfaces surface NNS cord-348746-yaf61cmx 39 24 . . . cord-348746-yaf61cmx 40 1 14 14 CD cord-348746-yaf61cmx 40 2 , , , cord-348746-yaf61cmx 40 3 15 15 CD cord-348746-yaf61cmx 40 4 Common common JJ cord-348746-yaf61cmx 40 5 historical historical JJ cord-348746-yaf61cmx 40 6 findings finding NNS cord-348746-yaf61cmx 40 7 in in IN cord-348746-yaf61cmx 40 8 cats cat NNS cord-348746-yaf61cmx 40 9 with with IN cord-348746-yaf61cmx 40 10 neurological neurological JJ cord-348746-yaf61cmx 40 11 FIP FIP NNP cord-348746-yaf61cmx 40 12 include include VBP cord-348746-yaf61cmx 40 13 dementia dementia NN cord-348746-yaf61cmx 40 14 , , , cord-348746-yaf61cmx 40 15 pica pica NN cord-348746-yaf61cmx 40 16 , , , cord-348746-yaf61cmx 40 17 seizures seizure NNS cord-348746-yaf61cmx 40 18 , , , cord-348746-yaf61cmx 40 19 inappropriate inappropriate JJ cord-348746-yaf61cmx 40 20 elimination elimination NN cord-348746-yaf61cmx 40 21 , , , cord-348746-yaf61cmx 40 22 incontinence incontinence NN cord-348746-yaf61cmx 40 23 ( ( -LRB- cord-348746-yaf61cmx 40 24 fecal fecal JJ cord-348746-yaf61cmx 40 25 and and CC cord-348746-yaf61cmx 40 26 urinary urinary JJ cord-348746-yaf61cmx 40 27 ) ) -RRB- cord-348746-yaf61cmx 40 28 , , , cord-348746-yaf61cmx 40 29 and and CC cord-348746-yaf61cmx 40 30 compulsive compulsive JJ cord-348746-yaf61cmx 40 31 licking licking NN cord-348746-yaf61cmx 40 32 . . . cord-348746-yaf61cmx 41 1 15 15 CD cord-348746-yaf61cmx 41 2 , , , cord-348746-yaf61cmx 41 3 16 16 CD cord-348746-yaf61cmx 41 4 Neurological neurological JJ cord-348746-yaf61cmx 41 5 examination examination NN cord-348746-yaf61cmx 41 6 may may MD cord-348746-yaf61cmx 41 7 identify identify VB cord-348746-yaf61cmx 41 8 ataxia ataxia NN cord-348746-yaf61cmx 41 9 , , , cord-348746-yaf61cmx 41 10 hyperesthesia hyperesthesia NNP cord-348746-yaf61cmx 41 11 , , , cord-348746-yaf61cmx 41 12 reduced reduce VBN cord-348746-yaf61cmx 41 13 consciousness consciousness NN cord-348746-yaf61cmx 41 14 , , , cord-348746-yaf61cmx 41 15 hyperreflexia hyperreflexia NNP cord-348746-yaf61cmx 41 16 , , , cord-348746-yaf61cmx 41 17 crossed cross VBN cord-348746-yaf61cmx 41 18 - - HYPH cord-348746-yaf61cmx 41 19 extensor extensor NN cord-348746-yaf61cmx 41 20 reflexes reflex NNS cord-348746-yaf61cmx 41 21 , , , cord-348746-yaf61cmx 41 22 reduced reduce VBN cord-348746-yaf61cmx 41 23 conscious conscious JJ cord-348746-yaf61cmx 41 24 proprioception proprioception NN cord-348746-yaf61cmx 41 25 , , , cord-348746-yaf61cmx 41 26 caudal caudal JJ cord-348746-yaf61cmx 41 27 paresis paresis NN cord-348746-yaf61cmx 41 28 , , , cord-348746-yaf61cmx 41 29 cerebellar cerebellar JJ cord-348746-yaf61cmx 41 30 - - HYPH cord-348746-yaf61cmx 41 31 vestibular vestibular JJ cord-348746-yaf61cmx 41 32 signs sign NNS cord-348746-yaf61cmx 41 33 , , , cord-348746-yaf61cmx 41 34 or or CC cord-348746-yaf61cmx 41 35 cranial cranial JJ cord-348746-yaf61cmx 41 36 nerve nerve NN cord-348746-yaf61cmx 41 37 deficits deficit NNS cord-348746-yaf61cmx 41 38 . . . cord-348746-yaf61cmx 42 1 14 14 CD cord-348746-yaf61cmx 42 2 , , , cord-348746-yaf61cmx 42 3 15 15 CD cord-348746-yaf61cmx 42 4 , , , cord-348746-yaf61cmx 42 5 [ [ -LRB- cord-348746-yaf61cmx 42 6 17 17 CD cord-348746-yaf61cmx 42 7 ] ] -RRB- cord-348746-yaf61cmx 42 8 [ [ -LRB- cord-348746-yaf61cmx 42 9 18 18 CD cord-348746-yaf61cmx 42 10 ] ] -RRB- cord-348746-yaf61cmx 42 11 [ [ -LRB- cord-348746-yaf61cmx 42 12 19 19 CD cord-348746-yaf61cmx 42 13 ] ] -RRB- cord-348746-yaf61cmx 43 1 Ophthalmic ophthalmic JJ cord-348746-yaf61cmx 43 2 lesions lesion NNS cord-348746-yaf61cmx 43 3 also also RB cord-348746-yaf61cmx 43 4 are be VBP cord-348746-yaf61cmx 43 5 common common JJ cord-348746-yaf61cmx 43 6 in in IN cord-348746-yaf61cmx 43 7 neurological neurological JJ cord-348746-yaf61cmx 43 8 FIP fip NN cord-348746-yaf61cmx 43 9 , , , cord-348746-yaf61cmx 43 10 including include VBG cord-348746-yaf61cmx 43 11 anterior anterior NNP cord-348746-yaf61cmx 43 12 uveitis uveitis NN cord-348746-yaf61cmx 43 13 , , , cord-348746-yaf61cmx 43 14 keratic keratic NNP cord-348746-yaf61cmx 43 15 precipitates precipitate NNS cord-348746-yaf61cmx 43 16 , , , cord-348746-yaf61cmx 43 17 flocculent flocculent JJ cord-348746-yaf61cmx 43 18 debris debris NN cord-348746-yaf61cmx 43 19 in in IN cord-348746-yaf61cmx 43 20 the the DT cord-348746-yaf61cmx 43 21 anterior anterior NNP cord-348746-yaf61cmx 43 22 chamber chamber NN cord-348746-yaf61cmx 43 23 , , , cord-348746-yaf61cmx 43 24 retinitis retinitis NN cord-348746-yaf61cmx 43 25 , , , cord-348746-yaf61cmx 43 26 and and CC cord-348746-yaf61cmx 43 27 anisocoria anisocoria NN cord-348746-yaf61cmx 43 28 . . . cord-348746-yaf61cmx 44 1 15 15 CD cord-348746-yaf61cmx 44 2 _SP cord-348746-yaf61cmx 44 3 Murine Murine NNP cord-348746-yaf61cmx 44 4 hepatitis hepatitis NN cord-348746-yaf61cmx 44 5 virus virus NN cord-348746-yaf61cmx 44 6 , , , cord-348746-yaf61cmx 44 7 like like IN cord-348746-yaf61cmx 44 8 FIPV FIPV NNP cord-348746-yaf61cmx 44 9 , , , cord-348746-yaf61cmx 44 10 can can MD cord-348746-yaf61cmx 44 11 produce produce VB cord-348746-yaf61cmx 44 12 either either DT cord-348746-yaf61cmx 44 13 systemic systemic JJ cord-348746-yaf61cmx 44 14 infection infection NN cord-348746-yaf61cmx 44 15 or or CC cord-348746-yaf61cmx 44 16 disease disease NN cord-348746-yaf61cmx 44 17 primarily primarily RB cord-348746-yaf61cmx 44 18 affecting affect VBG cord-348746-yaf61cmx 44 19 the the DT cord-348746-yaf61cmx 44 20 liver liver NN cord-348746-yaf61cmx 44 21 . . . cord-348746-yaf61cmx 45 1 Well well RB cord-348746-yaf61cmx 45 2 - - HYPH cord-348746-yaf61cmx 45 3 defined define VBN cord-348746-yaf61cmx 45 4 neurotropic neurotropic JJ cord-348746-yaf61cmx 45 5 genetic genetic JJ cord-348746-yaf61cmx 45 6 variants variant NNS cord-348746-yaf61cmx 45 7 of of IN cord-348746-yaf61cmx 45 8 MHV MHV NNP cord-348746-yaf61cmx 45 9 also also RB cord-348746-yaf61cmx 45 10 occur occur VBP cord-348746-yaf61cmx 45 11 , , , cord-348746-yaf61cmx 45 12 including include VBG cord-348746-yaf61cmx 45 13 a a DT cord-348746-yaf61cmx 45 14 well well RB cord-348746-yaf61cmx 45 15 - - HYPH cord-348746-yaf61cmx 45 16 studied study VBN cord-348746-yaf61cmx 45 17 variant variant NN cord-348746-yaf61cmx 45 18 designated designate VBN cord-348746-yaf61cmx 45 19 MHV MHV NNP cord-348746-yaf61cmx 45 20 - - HYPH cord-348746-yaf61cmx 45 21 JHM JHM NNP cord-348746-yaf61cmx 45 22 , , , cord-348746-yaf61cmx 45 23 which which WDT cord-348746-yaf61cmx 45 24 is be VBZ cord-348746-yaf61cmx 45 25 responsible responsible JJ cord-348746-yaf61cmx 45 26 for for IN cord-348746-yaf61cmx 45 27 progressive progressive JJ cord-348746-yaf61cmx 45 28 encephalomyelitis encephalomyelitis NN cord-348746-yaf61cmx 45 29 and and CC cord-348746-yaf61cmx 45 30 death death NN cord-348746-yaf61cmx 45 31 in in IN cord-348746-yaf61cmx 45 32 infected infected JJ cord-348746-yaf61cmx 45 33 mice mouse NNS cord-348746-yaf61cmx 45 34 and and CC cord-348746-yaf61cmx 45 35 rats rat NNS cord-348746-yaf61cmx 45 36 . . . cord-348746-yaf61cmx 46 1 Intranasal intranasal JJ cord-348746-yaf61cmx 46 2 or or CC cord-348746-yaf61cmx 46 3 intracranial intracranial JJ cord-348746-yaf61cmx 46 4 inoculation inoculation NN cord-348746-yaf61cmx 46 5 of of IN cord-348746-yaf61cmx 46 6 MHV MHV NNP cord-348746-yaf61cmx 46 7 - - HYPH cord-348746-yaf61cmx 46 8 JHM JHM NNP cord-348746-yaf61cmx 46 9 in in IN cord-348746-yaf61cmx 46 10 BALB BALB NNP cord-348746-yaf61cmx 46 11 / / SYM cord-348746-yaf61cmx 46 12 C C NNP cord-348746-yaf61cmx 46 13 or or CC cord-348746-yaf61cmx 46 14 C57Bl/6 C57Bl/6 NNP cord-348746-yaf61cmx 46 15 mice mouse NNS cord-348746-yaf61cmx 46 16 leads lead VBZ cord-348746-yaf61cmx 46 17 to to IN cord-348746-yaf61cmx 46 18 rapid rapid JJ cord-348746-yaf61cmx 46 19 , , , cord-348746-yaf61cmx 46 20 fatal fatal JJ cord-348746-yaf61cmx 46 21 encephalitis encephalitis RB cord-348746-yaf61cmx 46 22 . . . cord-348746-yaf61cmx 47 1 20 20 CD cord-348746-yaf61cmx 48 1 The the DT cord-348746-yaf61cmx 48 2 syndrome syndrome NN cord-348746-yaf61cmx 48 3 in in IN cord-348746-yaf61cmx 48 4 survivors survivor NNS cord-348746-yaf61cmx 48 5 ( ( -LRB- cord-348746-yaf61cmx 48 6 either either CC cord-348746-yaf61cmx 48 7 because because IN cord-348746-yaf61cmx 48 8 the the DT cord-348746-yaf61cmx 48 9 virus virus NN cord-348746-yaf61cmx 48 10 is be VBZ cord-348746-yaf61cmx 48 11 attenuated attenuate VBN cord-348746-yaf61cmx 48 12 or or CC cord-348746-yaf61cmx 48 13 the the DT cord-348746-yaf61cmx 48 14 host host NN cord-348746-yaf61cmx 48 15 is be VBZ cord-348746-yaf61cmx 48 16 resistant resistant JJ cord-348746-yaf61cmx 48 17 , , , cord-348746-yaf61cmx 48 18 vaccinated vaccinate VBN cord-348746-yaf61cmx 48 19 , , , cord-348746-yaf61cmx 48 20 or or CC cord-348746-yaf61cmx 48 21 a a DT cord-348746-yaf61cmx 48 22 pup pup NN cord-348746-yaf61cmx 48 23 from from IN cord-348746-yaf61cmx 48 24 a a DT cord-348746-yaf61cmx 48 25 vaccinated vaccinate VBN cord-348746-yaf61cmx 48 26 dams dam NNS cord-348746-yaf61cmx 48 27 ) ) -RRB- cord-348746-yaf61cmx 48 28 consists consist VBZ cord-348746-yaf61cmx 48 29 of of IN cord-348746-yaf61cmx 48 30 chronic chronic JJ cord-348746-yaf61cmx 48 31 demyelination demyelination NN cord-348746-yaf61cmx 48 32 and and CC cord-348746-yaf61cmx 48 33 hindlimb hindlimb NN cord-348746-yaf61cmx 48 34 paralysis paralysis NN cord-348746-yaf61cmx 48 35 21 21 CD cord-348746-yaf61cmx 48 36 and and CC cord-348746-yaf61cmx 48 37 has have VBZ cord-348746-yaf61cmx 48 38 been be VBN cord-348746-yaf61cmx 48 39 proposed propose VBN cord-348746-yaf61cmx 48 40 as as IN cord-348746-yaf61cmx 48 41 a a DT cord-348746-yaf61cmx 48 42 model model NN cord-348746-yaf61cmx 48 43 for for IN cord-348746-yaf61cmx 48 44 multiple multiple JJ cord-348746-yaf61cmx 48 45 sclerosis sclerosis NN cord-348746-yaf61cmx 48 46 . . . cord-348746-yaf61cmx 49 1 22 22 CD cord-348746-yaf61cmx 49 2 Determinants determinant NNS cord-348746-yaf61cmx 49 3 of of IN cord-348746-yaf61cmx 49 4 neurovirulence neurovirulence NNP cord-348746-yaf61cmx 49 5 are be VBP cord-348746-yaf61cmx 49 6 found find VBN cord-348746-yaf61cmx 49 7 in in IN cord-348746-yaf61cmx 49 8 the the DT cord-348746-yaf61cmx 49 9 MHV MHV NNP cord-348746-yaf61cmx 49 10 S S NNP cord-348746-yaf61cmx 49 11 gene gene NN cord-348746-yaf61cmx 49 12 . . . cord-348746-yaf61cmx 50 1 23 23 CD cord-348746-yaf61cmx 50 2 , , , cord-348746-yaf61cmx 50 3 24 24 CD cord-348746-yaf61cmx 51 1 A a DT cord-348746-yaf61cmx 51 2 second second JJ cord-348746-yaf61cmx 51 3 variant variant NN cord-348746-yaf61cmx 51 4 of of IN cord-348746-yaf61cmx 51 5 MHV MHV NNP cord-348746-yaf61cmx 51 6 , , , cord-348746-yaf61cmx 51 7 MHV MHV NNP cord-348746-yaf61cmx 51 8 - - HYPH cord-348746-yaf61cmx 51 9 OBLV60 OBLV60 NNP cord-348746-yaf61cmx 51 10 , , , cord-348746-yaf61cmx 51 11 leads lead VBZ cord-348746-yaf61cmx 51 12 to to IN cord-348746-yaf61cmx 51 13 neuronal neuronal JJ cord-348746-yaf61cmx 51 14 infection infection NN cord-348746-yaf61cmx 51 15 specifically specifically RB cord-348746-yaf61cmx 51 16 in in IN cord-348746-yaf61cmx 51 17 the the DT cord-348746-yaf61cmx 51 18 anterior anterior JJ cord-348746-yaf61cmx 51 19 olfactory olfactory JJ cord-348746-yaf61cmx 51 20 bulb bulb NN cord-348746-yaf61cmx 51 21 after after IN cord-348746-yaf61cmx 51 22 intranasal intranasal NN cord-348746-yaf61cmx 51 23 challenge challenge NN cord-348746-yaf61cmx 51 24 in in IN cord-348746-yaf61cmx 51 25 mice mouse NNS cord-348746-yaf61cmx 51 26 . . . cord-348746-yaf61cmx 52 1 25 25 CD cord-348746-yaf61cmx 52 2 Neurological Neurological NNP cord-348746-yaf61cmx 52 3 Disease Disease NNP cord-348746-yaf61cmx 53 1 The the DT cord-348746-yaf61cmx 53 2 definitive definitive JJ cord-348746-yaf61cmx 53 3 lesion lesion NN cord-348746-yaf61cmx 53 4 of of IN cord-348746-yaf61cmx 53 5 FIP FIP NNP cord-348746-yaf61cmx 53 6 is be VBZ cord-348746-yaf61cmx 53 7 a a DT cord-348746-yaf61cmx 53 8 pyogranuloma pyogranuloma NN cord-348746-yaf61cmx 53 9 that that WDT cord-348746-yaf61cmx 53 10 results result VBZ cord-348746-yaf61cmx 53 11 from from IN cord-348746-yaf61cmx 53 12 immune immune NN cord-348746-yaf61cmx 53 13 - - HYPH cord-348746-yaf61cmx 53 14 mediated mediate VBN cord-348746-yaf61cmx 53 15 phenomena phenomenon NNS cord-348746-yaf61cmx 53 16 secondary secondary JJ cord-348746-yaf61cmx 53 17 to to IN cord-348746-yaf61cmx 53 18 coronaviral coronaviral JJ cord-348746-yaf61cmx 53 19 infection infection NN cord-348746-yaf61cmx 53 20 of of IN cord-348746-yaf61cmx 53 21 macrophages macrophage NNS cord-348746-yaf61cmx 53 22 . . . cord-348746-yaf61cmx 54 1 The the DT cord-348746-yaf61cmx 54 2 most most RBS cord-348746-yaf61cmx 54 3 common common JJ cord-348746-yaf61cmx 54 4 sites site NNS cord-348746-yaf61cmx 54 5 are be VBP cord-348746-yaf61cmx 54 6 serosal serosal NN cord-348746-yaf61cmx 54 7 , , , cord-348746-yaf61cmx 54 8 pleural pleural JJ cord-348746-yaf61cmx 54 9 , , , cord-348746-yaf61cmx 54 10 meningeal meningeal JJ cord-348746-yaf61cmx 54 11 , , , cord-348746-yaf61cmx 54 12 ependymal ependymal JJ cord-348746-yaf61cmx 54 13 , , , cord-348746-yaf61cmx 54 14 or or CC cord-348746-yaf61cmx 54 15 uveal uveal JJ cord-348746-yaf61cmx 54 16 membranes membrane NNS cord-348746-yaf61cmx 54 17 . . . cord-348746-yaf61cmx 55 1 In in IN cord-348746-yaf61cmx 55 2 the the DT cord-348746-yaf61cmx 55 3 earliest early JJS cord-348746-yaf61cmx 55 4 stages stage NNS cord-348746-yaf61cmx 55 5 of of IN cord-348746-yaf61cmx 55 6 abdominal abdominal JJ cord-348746-yaf61cmx 55 7 FIP fip NN cord-348746-yaf61cmx 55 8 , , , cord-348746-yaf61cmx 55 9 diffuse diffuse VB cord-348746-yaf61cmx 55 10 alterations alteration NNS cord-348746-yaf61cmx 55 11 with with IN cord-348746-yaf61cmx 55 12 activated activate VBN cord-348746-yaf61cmx 55 13 mesothelial mesothelial JJ cord-348746-yaf61cmx 55 14 cells cell NNS cord-348746-yaf61cmx 55 15 and and CC cord-348746-yaf61cmx 55 16 a a DT cord-348746-yaf61cmx 55 17 few few JJ cord-348746-yaf61cmx 55 18 coronavirus coronavirus NN cord-348746-yaf61cmx 55 19 - - HYPH cord-348746-yaf61cmx 55 20 infected infect VBN cord-348746-yaf61cmx 55 21 macrophages macrophage NNS cord-348746-yaf61cmx 55 22 or or CC cord-348746-yaf61cmx 55 23 an an DT cord-348746-yaf61cmx 55 24 exudative exudative JJ cord-348746-yaf61cmx 55 25 precipitate precipitate NN cord-348746-yaf61cmx 55 26 may may MD cord-348746-yaf61cmx 55 27 be be VB cord-348746-yaf61cmx 55 28 detected detect VBN cord-348746-yaf61cmx 55 29 on on IN cord-348746-yaf61cmx 55 30 serosal serosal NN cord-348746-yaf61cmx 55 31 surfaces surface NNS cord-348746-yaf61cmx 55 32 . . . cord-348746-yaf61cmx 56 1 26 26 CD cord-348746-yaf61cmx 57 1 Larger large JJR cord-348746-yaf61cmx 57 2 pyogranulomas pyogranulomas NN cord-348746-yaf61cmx 57 3 become become VBN cord-348746-yaf61cmx 57 4 grossly grossly RB cord-348746-yaf61cmx 57 5 visible visible JJ cord-348746-yaf61cmx 57 6 , , , cord-348746-yaf61cmx 57 7 ranging range VBG cord-348746-yaf61cmx 57 8 from from IN cord-348746-yaf61cmx 57 9 small small JJ cord-348746-yaf61cmx 57 10 lesions lesion NNS cord-348746-yaf61cmx 57 11 , , , cord-348746-yaf61cmx 57 12 often often RB cord-348746-yaf61cmx 57 13 on on IN cord-348746-yaf61cmx 57 14 the the DT cord-348746-yaf61cmx 57 15 renal renal JJ cord-348746-yaf61cmx 57 16 capsular capsular NN cord-348746-yaf61cmx 57 17 surface surface NN cord-348746-yaf61cmx 57 18 , , , cord-348746-yaf61cmx 57 19 to to IN cord-348746-yaf61cmx 57 20 severe severe JJ cord-348746-yaf61cmx 57 21 , , , cord-348746-yaf61cmx 57 22 generalized generalized JJ cord-348746-yaf61cmx 57 23 miliary miliary JJ cord-348746-yaf61cmx 57 24 granulomatous granulomatous JJ cord-348746-yaf61cmx 57 25 lesions lesion NNS cord-348746-yaf61cmx 57 26 that that WDT cord-348746-yaf61cmx 57 27 distort distort VBP cord-348746-yaf61cmx 57 28 renal renal JJ cord-348746-yaf61cmx 57 29 surfaces surface NNS cord-348746-yaf61cmx 57 30 , , , cord-348746-yaf61cmx 57 31 disseminate disseminate VB cord-348746-yaf61cmx 57 32 throughout throughout IN cord-348746-yaf61cmx 57 33 the the DT cord-348746-yaf61cmx 57 34 omentum omentum NN cord-348746-yaf61cmx 57 35 and and CC cord-348746-yaf61cmx 57 36 gastrointestinal gastrointestinal JJ cord-348746-yaf61cmx 57 37 serosa serosa NN cord-348746-yaf61cmx 57 38 , , , cord-348746-yaf61cmx 57 39 and and CC cord-348746-yaf61cmx 57 40 invade invade VB cord-348746-yaf61cmx 57 41 splenic splenic JJ cord-348746-yaf61cmx 57 42 and and CC cord-348746-yaf61cmx 57 43 hepatic hepatic JJ cord-348746-yaf61cmx 57 44 parenchyma parenchyma NN cord-348746-yaf61cmx 57 45 . . . cord-348746-yaf61cmx 58 1 Gross gross JJ cord-348746-yaf61cmx 58 2 lesions lesion NNS cord-348746-yaf61cmx 58 3 of of IN cord-348746-yaf61cmx 58 4 FIP FIP NNP cord-348746-yaf61cmx 58 5 in in IN cord-348746-yaf61cmx 58 6 the the DT cord-348746-yaf61cmx 58 7 CNS CNS NNP cord-348746-yaf61cmx 58 8 may may MD cord-348746-yaf61cmx 58 9 be be VB cord-348746-yaf61cmx 58 10 subtle subtle JJ cord-348746-yaf61cmx 58 11 , , , cord-348746-yaf61cmx 58 12 with with IN cord-348746-yaf61cmx 58 13 ependymitis ependymitis NN cord-348746-yaf61cmx 58 14 , , , cord-348746-yaf61cmx 58 15 thickening thickening NN cord-348746-yaf61cmx 58 16 and and CC cord-348746-yaf61cmx 58 17 opacification opacification NN cord-348746-yaf61cmx 58 18 of of IN cord-348746-yaf61cmx 58 19 meninges meninge NNS cord-348746-yaf61cmx 58 20 , , , cord-348746-yaf61cmx 58 21 and and CC cord-348746-yaf61cmx 58 22 ventricular ventricular JJ cord-348746-yaf61cmx 58 23 dilatation dilatation NN cord-348746-yaf61cmx 58 24 , , , cord-348746-yaf61cmx 58 25 usually usually RB cord-348746-yaf61cmx 58 26 in in IN cord-348746-yaf61cmx 58 27 the the DT cord-348746-yaf61cmx 58 28 fourth fourth JJ cord-348746-yaf61cmx 58 29 ventricle ventricle NN cord-348746-yaf61cmx 58 30 and and CC cord-348746-yaf61cmx 58 31 least least JJS cord-348746-yaf61cmx 58 32 often often RB cord-348746-yaf61cmx 58 33 in in IN cord-348746-yaf61cmx 58 34 the the DT cord-348746-yaf61cmx 58 35 lateral lateral JJ cord-348746-yaf61cmx 58 36 ventricles ventricle NNS cord-348746-yaf61cmx 58 37 . . . cord-348746-yaf61cmx 59 1 15 15 CD cord-348746-yaf61cmx 59 2 Lesions lesion NNS cord-348746-yaf61cmx 59 3 occur occur VBP cord-348746-yaf61cmx 59 4 most most RBS cord-348746-yaf61cmx 59 5 commonly commonly RB cord-348746-yaf61cmx 59 6 on on IN cord-348746-yaf61cmx 59 7 the the DT cord-348746-yaf61cmx 59 8 ventral ventral JJ cord-348746-yaf61cmx 59 9 surface surface NN cord-348746-yaf61cmx 59 10 of of IN cord-348746-yaf61cmx 59 11 the the DT cord-348746-yaf61cmx 59 12 brain brain NN cord-348746-yaf61cmx 59 13 , , , cord-348746-yaf61cmx 59 14 often often RB cord-348746-yaf61cmx 59 15 accompanied accompany VBN cord-348746-yaf61cmx 59 16 by by IN cord-348746-yaf61cmx 59 17 secondary secondary JJ cord-348746-yaf61cmx 59 18 obstructive obstructive JJ cord-348746-yaf61cmx 59 19 hydrocephalus hydrocephalus NN cord-348746-yaf61cmx 59 20 . . . cord-348746-yaf61cmx 60 1 Histopathologically histopathologically RB cord-348746-yaf61cmx 60 2 , , , cord-348746-yaf61cmx 60 3 lesions lesion NNS cord-348746-yaf61cmx 60 4 in in IN cord-348746-yaf61cmx 60 5 the the DT cord-348746-yaf61cmx 60 6 brains brain NNS cord-348746-yaf61cmx 60 7 of of IN cord-348746-yaf61cmx 60 8 cats cat NNS cord-348746-yaf61cmx 60 9 with with IN cord-348746-yaf61cmx 60 10 FIP FIP NNP cord-348746-yaf61cmx 60 11 consist consist VBP cord-348746-yaf61cmx 60 12 of of IN cord-348746-yaf61cmx 60 13 meningitis meningitis NN cord-348746-yaf61cmx 60 14 , , , cord-348746-yaf61cmx 60 15 ependymitis ependymitis NNP cord-348746-yaf61cmx 60 16 ( ( -LRB- cord-348746-yaf61cmx 60 17 ranging range VBG cord-348746-yaf61cmx 60 18 from from IN cord-348746-yaf61cmx 60 19 mild mild JJ cord-348746-yaf61cmx 60 20 ependymal ependymal JJ cord-348746-yaf61cmx 60 21 infiltration infiltration NN cord-348746-yaf61cmx 60 22 to to TO cord-348746-yaf61cmx 60 23 complete complete VB cord-348746-yaf61cmx 60 24 effacement effacement NN cord-348746-yaf61cmx 60 25 of of IN cord-348746-yaf61cmx 60 26 the the DT cord-348746-yaf61cmx 60 27 ependymal ependymal JJ cord-348746-yaf61cmx 60 28 lining lining NN cord-348746-yaf61cmx 60 29 by by IN cord-348746-yaf61cmx 60 30 a a DT cord-348746-yaf61cmx 60 31 heavy heavy JJ cord-348746-yaf61cmx 60 32 infiltrate infiltrate NN cord-348746-yaf61cmx 60 33 of of IN cord-348746-yaf61cmx 60 34 histiocytes histiocyte NNS cord-348746-yaf61cmx 60 35 and and CC cord-348746-yaf61cmx 60 36 lymphocytes lymphocyte NNS cord-348746-yaf61cmx 60 37 ) ) -RRB- cord-348746-yaf61cmx 60 38 , , , cord-348746-yaf61cmx 60 39 periventriculitis periventriculitis NN cord-348746-yaf61cmx 60 40 , , , cord-348746-yaf61cmx 60 41 and and CC cord-348746-yaf61cmx 60 42 choroiditis choroiditis NN cord-348746-yaf61cmx 60 43 of of IN cord-348746-yaf61cmx 60 44 varying vary VBG cord-348746-yaf61cmx 60 45 severity severity NN cord-348746-yaf61cmx 60 46 , , , cord-348746-yaf61cmx 60 47 often often RB cord-348746-yaf61cmx 60 48 superficial superficial JJ cord-348746-yaf61cmx 60 49 and and CC cord-348746-yaf61cmx 60 50 oriented orient VBN cord-348746-yaf61cmx 60 51 around around IN cord-348746-yaf61cmx 60 52 the the DT cord-348746-yaf61cmx 60 53 ventricles ventricle NNS cord-348746-yaf61cmx 60 54 , , , cord-348746-yaf61cmx 60 55 with with IN cord-348746-yaf61cmx 60 56 dense dense JJ cord-348746-yaf61cmx 60 57 infiltrates infiltrate NNS cord-348746-yaf61cmx 60 58 of of IN cord-348746-yaf61cmx 60 59 lymphocytes lymphocyte NNS cord-348746-yaf61cmx 60 60 , , , cord-348746-yaf61cmx 60 61 plasma plasma NN cord-348746-yaf61cmx 60 62 cells cell NNS cord-348746-yaf61cmx 60 63 , , , cord-348746-yaf61cmx 60 64 neutrophils neutrophil NNS cord-348746-yaf61cmx 60 65 , , , cord-348746-yaf61cmx 60 66 and and CC cord-348746-yaf61cmx 60 67 macrophages macrophage NNS cord-348746-yaf61cmx 60 68 . . . cord-348746-yaf61cmx 61 1 14 14 CD cord-348746-yaf61cmx 61 2 , , , cord-348746-yaf61cmx 61 3 15 15 CD cord-348746-yaf61cmx 61 4 , , , cord-348746-yaf61cmx 61 5 [ [ -LRB- cord-348746-yaf61cmx 61 6 27 27 CD cord-348746-yaf61cmx 61 7 ] ] -RRB- cord-348746-yaf61cmx 62 1 [ [ -LRB- cord-348746-yaf61cmx 62 2 28 28 CD cord-348746-yaf61cmx 62 3 ] ] -RRB- cord-348746-yaf61cmx 63 1 [ [ -LRB- cord-348746-yaf61cmx 63 2 29 29 CD cord-348746-yaf61cmx 63 3 ] ] -RRB- cord-348746-yaf61cmx 64 1 [ [ -LRB- cord-348746-yaf61cmx 64 2 30 30 CD cord-348746-yaf61cmx 64 3 ] ] -RRB- cord-348746-yaf61cmx 64 4 [ [ -LRB- cord-348746-yaf61cmx 64 5 31 31 CD cord-348746-yaf61cmx 64 6 ] ] -RRB- cord-348746-yaf61cmx 64 7 Meningitis Meningitis NNP cord-348746-yaf61cmx 64 8 may may MD cord-348746-yaf61cmx 64 9 be be VB cord-348746-yaf61cmx 64 10 more more RBR cord-348746-yaf61cmx 64 11 severe severe JJ cord-348746-yaf61cmx 64 12 on on IN cord-348746-yaf61cmx 64 13 the the DT cord-348746-yaf61cmx 64 14 ventrocaudal ventrocaudal JJ cord-348746-yaf61cmx 64 15 surfaces surface NNS cord-348746-yaf61cmx 64 16 of of IN cord-348746-yaf61cmx 64 17 the the DT cord-348746-yaf61cmx 64 18 brain brain NN cord-348746-yaf61cmx 64 19 , , , cord-348746-yaf61cmx 64 20 especially especially RB cord-348746-yaf61cmx 64 21 at at IN cord-348746-yaf61cmx 64 22 the the DT cord-348746-yaf61cmx 64 23 base base NN cord-348746-yaf61cmx 64 24 of of IN cord-348746-yaf61cmx 64 25 the the DT cord-348746-yaf61cmx 64 26 cerebellum cerebellum NN cord-348746-yaf61cmx 64 27 and and CC cord-348746-yaf61cmx 64 28 the the DT cord-348746-yaf61cmx 64 29 brainstem brainstem NN cord-348746-yaf61cmx 64 30 , , , cord-348746-yaf61cmx 64 31 including include VBG cord-348746-yaf61cmx 64 32 the the DT cord-348746-yaf61cmx 64 33 medulla medulla NN cord-348746-yaf61cmx 64 34 oblongata oblongata NN cord-348746-yaf61cmx 64 35 . . . cord-348746-yaf61cmx 65 1 In in IN cord-348746-yaf61cmx 65 2 the the DT cord-348746-yaf61cmx 65 3 meninges meninge NNS cord-348746-yaf61cmx 65 4 , , , cord-348746-yaf61cmx 65 5 the the DT cord-348746-yaf61cmx 65 6 inflammatory inflammatory JJ cord-348746-yaf61cmx 65 7 cells cell NNS cord-348746-yaf61cmx 65 8 may may MD cord-348746-yaf61cmx 65 9 have have VB cord-348746-yaf61cmx 65 10 a a DT cord-348746-yaf61cmx 65 11 predominantly predominantly RB cord-348746-yaf61cmx 65 12 perivascular perivascular JJ cord-348746-yaf61cmx 65 13 distribution distribution NN cord-348746-yaf61cmx 65 14 , , , cord-348746-yaf61cmx 65 15 forming form VBG cord-348746-yaf61cmx 65 16 cuffs cuff NNS cord-348746-yaf61cmx 65 17 around around IN cord-348746-yaf61cmx 65 18 arteries artery NNS cord-348746-yaf61cmx 65 19 ( ( -LRB- cord-348746-yaf61cmx 65 20 periarteritis periarteritis NNP cord-348746-yaf61cmx 65 21 ) ) -RRB- cord-348746-yaf61cmx 65 22 and and CC cord-348746-yaf61cmx 65 23 infiltrating infiltrate VBG cord-348746-yaf61cmx 65 24 the the DT cord-348746-yaf61cmx 65 25 wall wall NN cord-348746-yaf61cmx 65 26 of of IN cord-348746-yaf61cmx 65 27 veins vein NNS cord-348746-yaf61cmx 65 28 and and CC cord-348746-yaf61cmx 65 29 venules venule NNS cord-348746-yaf61cmx 65 30 ( ( -LRB- cord-348746-yaf61cmx 65 31 phlebitis phlebitis NN cord-348746-yaf61cmx 65 32 ) ) -RRB- cord-348746-yaf61cmx 65 33 , , , cord-348746-yaf61cmx 65 34 with with IN cord-348746-yaf61cmx 65 35 exudation exudation NN cord-348746-yaf61cmx 65 36 of of IN cord-348746-yaf61cmx 65 37 a a DT cord-348746-yaf61cmx 65 38 cell cell NN cord-348746-yaf61cmx 65 39 - - HYPH cord-348746-yaf61cmx 65 40 and and CC cord-348746-yaf61cmx 65 41 protein protein NN cord-348746-yaf61cmx 65 42 - - HYPH cord-348746-yaf61cmx 65 43 rich rich JJ cord-348746-yaf61cmx 65 44 edema edema NN cord-348746-yaf61cmx 65 45 fluid fluid NN cord-348746-yaf61cmx 65 46 , , , cord-348746-yaf61cmx 65 47 and and CC cord-348746-yaf61cmx 65 48 periventricular periventricular NNP cord-348746-yaf61cmx 65 49 reactive reactive JJ cord-348746-yaf61cmx 65 50 astrocytosis astrocytosis NNP cord-348746-yaf61cmx 65 51 . . . cord-348746-yaf61cmx 66 1 The the DT cord-348746-yaf61cmx 66 2 inflammation inflammation NN cord-348746-yaf61cmx 66 3 may may MD cord-348746-yaf61cmx 66 4 extend extend VB cord-348746-yaf61cmx 66 5 into into IN cord-348746-yaf61cmx 66 6 the the DT cord-348746-yaf61cmx 66 7 superficial superficial JJ cord-348746-yaf61cmx 66 8 neuropil neuropil NN cord-348746-yaf61cmx 66 9 , , , cord-348746-yaf61cmx 66 10 as as RB cord-348746-yaf61cmx 66 11 well well RB cord-348746-yaf61cmx 66 12 as as IN cord-348746-yaf61cmx 66 13 into into IN cord-348746-yaf61cmx 66 14 cranial cranial JJ cord-348746-yaf61cmx 66 15 nerve nerve NN cord-348746-yaf61cmx 66 16 roots root NNS cord-348746-yaf61cmx 66 17 . . . cord-348746-yaf61cmx 67 1 15 15 CD cord-348746-yaf61cmx 68 1 If if IN cord-348746-yaf61cmx 68 2 lesions lesion NNS cord-348746-yaf61cmx 68 3 are be VBP cord-348746-yaf61cmx 68 4 deep deep JJ cord-348746-yaf61cmx 68 5 , , , cord-348746-yaf61cmx 68 6 they -PRON- PRP cord-348746-yaf61cmx 68 7 usually usually RB cord-348746-yaf61cmx 68 8 are be VBP cord-348746-yaf61cmx 68 9 perivascular perivascular JJ cord-348746-yaf61cmx 68 10 with with IN cord-348746-yaf61cmx 68 11 scattered scatter VBN cord-348746-yaf61cmx 68 12 glial glial JJ cord-348746-yaf61cmx 68 13 nodules nodule NNS cord-348746-yaf61cmx 68 14 . . . cord-348746-yaf61cmx 69 1 27 27 CD cord-348746-yaf61cmx 70 1 Hydrocephalus Hydrocephalus NNP cord-348746-yaf61cmx 70 2 is be VBZ cord-348746-yaf61cmx 70 3 seen see VBN cord-348746-yaf61cmx 70 4 in in IN cord-348746-yaf61cmx 70 5 association association NN cord-348746-yaf61cmx 70 6 with with IN cord-348746-yaf61cmx 70 7 leptomeningitis leptomeningitis NNP cord-348746-yaf61cmx 70 8 , , , cord-348746-yaf61cmx 70 9 meningeal meningeal JJ cord-348746-yaf61cmx 70 10 fibrosis fibrosis NN cord-348746-yaf61cmx 70 11 , , , cord-348746-yaf61cmx 70 12 accumulation accumulation NN cord-348746-yaf61cmx 70 13 of of IN cord-348746-yaf61cmx 70 14 cellular cellular JJ cord-348746-yaf61cmx 70 15 debris debris NN cord-348746-yaf61cmx 70 16 , , , cord-348746-yaf61cmx 70 17 and and CC cord-348746-yaf61cmx 70 18 obstruction obstruction NN cord-348746-yaf61cmx 70 19 of of IN cord-348746-yaf61cmx 70 20 the the DT cord-348746-yaf61cmx 70 21 cerebrospinal cerebrospinal JJ cord-348746-yaf61cmx 70 22 fluid fluid NN cord-348746-yaf61cmx 70 23 flow flow NN cord-348746-yaf61cmx 70 24 . . . cord-348746-yaf61cmx 71 1 Pathologic pathologic JJ cord-348746-yaf61cmx 71 2 lesions lesion NNS cord-348746-yaf61cmx 71 3 after after IN cord-348746-yaf61cmx 71 4 MHV MHV NNP cord-348746-yaf61cmx 71 5 infection infection NN cord-348746-yaf61cmx 71 6 in in IN cord-348746-yaf61cmx 71 7 the the DT cord-348746-yaf61cmx 71 8 brains brain NNS cord-348746-yaf61cmx 71 9 of of IN cord-348746-yaf61cmx 71 10 rats rat NNS cord-348746-yaf61cmx 71 11 and and CC cord-348746-yaf61cmx 71 12 mice mouse NNS cord-348746-yaf61cmx 71 13 are be VBP cord-348746-yaf61cmx 71 14 variable variable JJ cord-348746-yaf61cmx 71 15 , , , cord-348746-yaf61cmx 71 16 depending depend VBG cord-348746-yaf61cmx 71 17 on on IN cord-348746-yaf61cmx 71 18 viral viral JJ cord-348746-yaf61cmx 71 19 dose dose NN cord-348746-yaf61cmx 71 20 and and CC cord-348746-yaf61cmx 71 21 route route NN cord-348746-yaf61cmx 71 22 of of IN cord-348746-yaf61cmx 71 23 administration administration NN cord-348746-yaf61cmx 71 24 and and CC cord-348746-yaf61cmx 71 25 rodent rodent NN cord-348746-yaf61cmx 71 26 genotype genotype NN cord-348746-yaf61cmx 71 27 , , , cord-348746-yaf61cmx 71 28 age age NN cord-348746-yaf61cmx 71 29 , , , cord-348746-yaf61cmx 71 30 and and CC cord-348746-yaf61cmx 71 31 immunological immunological JJ cord-348746-yaf61cmx 71 32 characteristics characteristic NNS cord-348746-yaf61cmx 71 33 . . . cord-348746-yaf61cmx 72 1 32 32 CD cord-348746-yaf61cmx 73 1 In in IN cord-348746-yaf61cmx 73 2 severe severe JJ cord-348746-yaf61cmx 73 3 acute acute JJ cord-348746-yaf61cmx 73 4 JHM JHM NNP cord-348746-yaf61cmx 73 5 encephalitis encephalitis RB cord-348746-yaf61cmx 73 6 , , , cord-348746-yaf61cmx 73 7 necrotizing necrotize VBG cord-348746-yaf61cmx 73 8 lesions lesion NNS cord-348746-yaf61cmx 73 9 are be VBP cord-348746-yaf61cmx 73 10 found find VBN cord-348746-yaf61cmx 73 11 in in IN cord-348746-yaf61cmx 73 12 the the DT cord-348746-yaf61cmx 73 13 gray gray JJ cord-348746-yaf61cmx 73 14 and and CC cord-348746-yaf61cmx 73 15 white white JJ cord-348746-yaf61cmx 73 16 matter matter NN cord-348746-yaf61cmx 73 17 , , , cord-348746-yaf61cmx 73 18 with with IN cord-348746-yaf61cmx 73 19 axonal axonal JJ cord-348746-yaf61cmx 73 20 changes change NNS cord-348746-yaf61cmx 73 21 , , , cord-348746-yaf61cmx 73 22 including include VBG cord-348746-yaf61cmx 73 23 disintegration disintegration NN cord-348746-yaf61cmx 73 24 of of IN cord-348746-yaf61cmx 73 25 neurofilaments neurofilament NNS cord-348746-yaf61cmx 73 26 . . . cord-348746-yaf61cmx 74 1 32 32 CD cord-348746-yaf61cmx 75 1 Within within IN cord-348746-yaf61cmx 75 2 the the DT cord-348746-yaf61cmx 75 3 necrotic necrotic JJ cord-348746-yaf61cmx 75 4 areas area NNS cord-348746-yaf61cmx 75 5 , , , cord-348746-yaf61cmx 75 6 perivascular perivascular NNP cord-348746-yaf61cmx 75 7 neutrophilic neutrophilic NNP cord-348746-yaf61cmx 75 8 infiltrates infiltrate VBZ cord-348746-yaf61cmx 75 9 occur occur VBP cord-348746-yaf61cmx 75 10 especially especially RB cord-348746-yaf61cmx 75 11 in in IN cord-348746-yaf61cmx 75 12 the the DT cord-348746-yaf61cmx 75 13 subependyma subependyma NN cord-348746-yaf61cmx 75 14 , , , cord-348746-yaf61cmx 75 15 choroid choroid NN cord-348746-yaf61cmx 75 16 , , , cord-348746-yaf61cmx 75 17 and and CC cord-348746-yaf61cmx 75 18 meninges meninge NNS cord-348746-yaf61cmx 75 19 . . . cord-348746-yaf61cmx 76 1 In in IN cord-348746-yaf61cmx 76 2 acute acute JJ cord-348746-yaf61cmx 76 3 MHV MHV NNP cord-348746-yaf61cmx 76 4 - - HYPH cord-348746-yaf61cmx 76 5 A59 A59 NNP cord-348746-yaf61cmx 76 6 infection infection NN cord-348746-yaf61cmx 76 7 in in IN cord-348746-yaf61cmx 76 8 CD8ϩ CD8ϩ NNP cord-348746-yaf61cmx 76 9 T T NNP cord-348746-yaf61cmx 76 10 - - HYPH cord-348746-yaf61cmx 76 11 cell cell NN cord-348746-yaf61cmx 76 12 deficient deficient JJ cord-348746-yaf61cmx 76 13 mice mouse NNS cord-348746-yaf61cmx 76 14 , , , cord-348746-yaf61cmx 76 15 periventricular periventricular NNP cord-348746-yaf61cmx 76 16 encephalitis encephalitis RB cord-348746-yaf61cmx 76 17 occurs occur VBZ cord-348746-yaf61cmx 76 18 with with IN cord-348746-yaf61cmx 76 19 lymphocytic lymphocytic JJ cord-348746-yaf61cmx 76 20 infiltration infiltration NN cord-348746-yaf61cmx 76 21 into into IN cord-348746-yaf61cmx 76 22 the the DT cord-348746-yaf61cmx 76 23 choroid choroid JJ cord-348746-yaf61cmx 76 24 plexus plexus NN cord-348746-yaf61cmx 76 25 , , , cord-348746-yaf61cmx 76 26 ependyma ependyma NNP cord-348746-yaf61cmx 76 27 , , , cord-348746-yaf61cmx 76 28 and and CC cord-348746-yaf61cmx 76 29 subependymal subependymal NNP cord-348746-yaf61cmx 76 30 brain brain NN cord-348746-yaf61cmx 76 31 tissue tissue NN cord-348746-yaf61cmx 76 32 . . . cord-348746-yaf61cmx 77 1 33 33 CD cord-348746-yaf61cmx 77 2 Lesions lesion NNS cord-348746-yaf61cmx 77 3 in in IN cord-348746-yaf61cmx 77 4 MHV MHV NNP cord-348746-yaf61cmx 77 5 - - HYPH cord-348746-yaf61cmx 77 6 OBLV60 OBLV60 NNP cord-348746-yaf61cmx 77 7 consist consist NN cord-348746-yaf61cmx 77 8 of of IN cord-348746-yaf61cmx 77 9 local local JJ cord-348746-yaf61cmx 77 10 neuronal neuronal JJ cord-348746-yaf61cmx 77 11 infection infection NN cord-348746-yaf61cmx 77 12 , , , cord-348746-yaf61cmx 77 13 some some DT cord-348746-yaf61cmx 77 14 mitral mitral JJ cord-348746-yaf61cmx 77 15 cell cell NN cord-348746-yaf61cmx 77 16 destruction destruction NN cord-348746-yaf61cmx 77 17 , , , cord-348746-yaf61cmx 77 18 and and CC cord-348746-yaf61cmx 77 19 T t NN cord-348746-yaf61cmx 77 20 - - HYPH cord-348746-yaf61cmx 77 21 cell cell NN cord-348746-yaf61cmx 77 22 inflammation inflammation NN cord-348746-yaf61cmx 77 23 with with IN cord-348746-yaf61cmx 77 24 astrocytosis astrocytosis NNP cord-348746-yaf61cmx 77 25 . . . cord-348746-yaf61cmx 78 1 25 25 CD cord-348746-yaf61cmx 79 1 Some some DT cord-348746-yaf61cmx 79 2 evidence evidence NN cord-348746-yaf61cmx 79 3 suggests suggest VBZ cord-348746-yaf61cmx 79 4 a a DT cord-348746-yaf61cmx 79 5 pathological pathological JJ cord-348746-yaf61cmx 79 6 component component NN cord-348746-yaf61cmx 79 7 of of IN cord-348746-yaf61cmx 79 8 vasculitis vasculitis NN cord-348746-yaf61cmx 79 9 , , , cord-348746-yaf61cmx 79 10 with with IN cord-348746-yaf61cmx 79 11 mouse mouse NN cord-348746-yaf61cmx 79 12 endothelial endothelial JJ cord-348746-yaf61cmx 79 13 cell cell NN cord-348746-yaf61cmx 79 14 lines line NNS cord-348746-yaf61cmx 79 15 susceptible susceptible JJ cord-348746-yaf61cmx 79 16 to to IN cord-348746-yaf61cmx 79 17 MHV MHV NNP cord-348746-yaf61cmx 79 18 - - HYPH cord-348746-yaf61cmx 79 19 JHM JHM NNP cord-348746-yaf61cmx 79 20 exhibiting exhibit VBG cord-348746-yaf61cmx 79 21 cytopathology cytopathology NN cord-348746-yaf61cmx 79 22 within within IN cord-348746-yaf61cmx 79 23 several several JJ cord-348746-yaf61cmx 79 24 days day NNS cord-348746-yaf61cmx 79 25 of of IN cord-348746-yaf61cmx 79 26 infection infection NN cord-348746-yaf61cmx 79 27 . . . cord-348746-yaf61cmx 80 1 34 34 CD cord-348746-yaf61cmx 81 1 The the DT cord-348746-yaf61cmx 81 2 subacute subacute JJ cord-348746-yaf61cmx 81 3 to to IN cord-348746-yaf61cmx 81 4 chronic chronic JJ cord-348746-yaf61cmx 81 5 immune immune NN cord-348746-yaf61cmx 81 6 - - HYPH cord-348746-yaf61cmx 81 7 modulated modulate VBN cord-348746-yaf61cmx 81 8 pathological pathological JJ cord-348746-yaf61cmx 81 9 changes change NNS cord-348746-yaf61cmx 81 10 that that WDT cord-348746-yaf61cmx 81 11 occur occur VBP cord-348746-yaf61cmx 81 12 with with IN cord-348746-yaf61cmx 81 13 manipulation manipulation NN cord-348746-yaf61cmx 81 14 of of IN cord-348746-yaf61cmx 81 15 the the DT cord-348746-yaf61cmx 81 16 MHV MHV NNP cord-348746-yaf61cmx 81 17 - - HYPH cord-348746-yaf61cmx 81 18 JHM JHM NNP cord-348746-yaf61cmx 81 19 system system NN cord-348746-yaf61cmx 81 20 are be VBP cord-348746-yaf61cmx 81 21 particularly particularly RB cord-348746-yaf61cmx 81 22 relevant relevant JJ cord-348746-yaf61cmx 81 23 to to IN cord-348746-yaf61cmx 81 24 the the DT cord-348746-yaf61cmx 81 25 murine murine JJ cord-348746-yaf61cmx 81 26 model model NN cord-348746-yaf61cmx 81 27 of of IN cord-348746-yaf61cmx 81 28 FIP FIP NNP cord-348746-yaf61cmx 81 29 . . . cord-348746-yaf61cmx 82 1 Depending depend VBG cord-348746-yaf61cmx 82 2 on on IN cord-348746-yaf61cmx 82 3 mouse mouse NN cord-348746-yaf61cmx 82 4 strain strain NN cord-348746-yaf61cmx 82 5 and and CC cord-348746-yaf61cmx 82 6 immunological immunological JJ cord-348746-yaf61cmx 82 7 status status NN cord-348746-yaf61cmx 82 8 , , , cord-348746-yaf61cmx 82 9 MHV MHV NNP cord-348746-yaf61cmx 82 10 - - HYPH cord-348746-yaf61cmx 82 11 JHM JHM NNP cord-348746-yaf61cmx 82 12 produces produce VBZ cord-348746-yaf61cmx 82 13 meningeal meningeal JJ cord-348746-yaf61cmx 82 14 inflammation inflammation NN cord-348746-yaf61cmx 82 15 associated associate VBN cord-348746-yaf61cmx 82 16 with with IN cord-348746-yaf61cmx 82 17 T t NN cord-348746-yaf61cmx 82 18 - - HYPH cord-348746-yaf61cmx 82 19 cells cell NNS cord-348746-yaf61cmx 82 20 and and CC cord-348746-yaf61cmx 82 21 macrophages macrophage NNS cord-348746-yaf61cmx 82 22 and and CC cord-348746-yaf61cmx 82 23 demyelination demyelination NN cord-348746-yaf61cmx 82 24 but but CC cord-348746-yaf61cmx 82 25 relatively relatively RB cord-348746-yaf61cmx 82 26 little little JJ cord-348746-yaf61cmx 82 27 disease disease NN cord-348746-yaf61cmx 82 28 in in IN cord-348746-yaf61cmx 82 29 axons axon NNS cord-348746-yaf61cmx 82 30 . . . cord-348746-yaf61cmx 83 1 Demyelination Demyelination NNP cord-348746-yaf61cmx 83 2 occurs occur VBZ cord-348746-yaf61cmx 83 3 within within IN cord-348746-yaf61cmx 83 4 and and CC cord-348746-yaf61cmx 83 5 adjacent adjacent JJ cord-348746-yaf61cmx 83 6 to to IN cord-348746-yaf61cmx 83 7 areas area NNS cord-348746-yaf61cmx 83 8 of of IN cord-348746-yaf61cmx 83 9 inflammation inflammation NN cord-348746-yaf61cmx 83 10 and and CC cord-348746-yaf61cmx 83 11 astrocytic astrocytic JJ cord-348746-yaf61cmx 83 12 proliferation proliferation NN cord-348746-yaf61cmx 83 13 . . . cord-348746-yaf61cmx 84 1 32 32 CD cord-348746-yaf61cmx 84 2 , , , cord-348746-yaf61cmx 84 3 35 35 CD cord-348746-yaf61cmx 84 4 Neutrophils neutrophil NNS cord-348746-yaf61cmx 84 5 and and CC cord-348746-yaf61cmx 84 6 monocytes monocyte NNS cord-348746-yaf61cmx 84 7 have have VBP cord-348746-yaf61cmx 84 8 been be VBN cord-348746-yaf61cmx 84 9 observed observe VBN cord-348746-yaf61cmx 84 10 infiltrating infiltrate VBG cord-348746-yaf61cmx 84 11 through through IN cord-348746-yaf61cmx 84 12 endothelial endothelial JJ cord-348746-yaf61cmx 84 13 cell cell NN cord-348746-yaf61cmx 84 14 junctions junction NNS cord-348746-yaf61cmx 84 15 and and CC cord-348746-yaf61cmx 84 16 participating participate VBG cord-348746-yaf61cmx 84 17 in in IN cord-348746-yaf61cmx 84 18 the the DT cord-348746-yaf61cmx 84 19 phagocytosis phagocytosis NN cord-348746-yaf61cmx 84 20 of of IN cord-348746-yaf61cmx 84 21 myelin myelin JJ cord-348746-yaf61cmx 84 22 debris debris NN cord-348746-yaf61cmx 84 23 . . . cord-348746-yaf61cmx 85 1 32 32 CD cord-348746-yaf61cmx 85 2 Perivascular Perivascular NNP cord-348746-yaf61cmx 85 3 cuffing cuffing NN cord-348746-yaf61cmx 85 4 by by IN cord-348746-yaf61cmx 85 5 macrophages macrophage NNS cord-348746-yaf61cmx 85 6 is be VBZ cord-348746-yaf61cmx 85 7 observed observe VBN cord-348746-yaf61cmx 85 8 in in IN cord-348746-yaf61cmx 85 9 chronic chronic JJ cord-348746-yaf61cmx 85 10 encephalitis encephalitis RB cord-348746-yaf61cmx 85 11 , , , cord-348746-yaf61cmx 85 12 as as IN cord-348746-yaf61cmx 85 13 in in IN cord-348746-yaf61cmx 85 14 FIP FIP NNP cord-348746-yaf61cmx 85 15 . . . cord-348746-yaf61cmx 86 1 The the DT cord-348746-yaf61cmx 86 2 route route NN cord-348746-yaf61cmx 86 3 of of IN cord-348746-yaf61cmx 86 4 entry entry NN cord-348746-yaf61cmx 86 5 of of IN cord-348746-yaf61cmx 86 6 FIPV FIPV NNS cord-348746-yaf61cmx 86 7 into into IN cord-348746-yaf61cmx 86 8 the the DT cord-348746-yaf61cmx 86 9 CNS CNS NNP cord-348746-yaf61cmx 86 10 is be VBZ cord-348746-yaf61cmx 86 11 unknown unknown JJ cord-348746-yaf61cmx 86 12 . . . cord-348746-yaf61cmx 87 1 The the DT cord-348746-yaf61cmx 87 2 FIPV FIPV NNP cord-348746-yaf61cmx 87 3 virus virus NN cord-348746-yaf61cmx 87 4 probably probably RB cord-348746-yaf61cmx 87 5 travels travel VBZ cord-348746-yaf61cmx 87 6 hematogenously hematogenously RB cord-348746-yaf61cmx 87 7 in in IN cord-348746-yaf61cmx 87 8 macrophages macrophage NNS cord-348746-yaf61cmx 87 9 , , , cord-348746-yaf61cmx 87 10 and and CC cord-348746-yaf61cmx 87 11 1 1 CD cord-348746-yaf61cmx 87 12 study study NN cord-348746-yaf61cmx 87 13 reported report VBD cord-348746-yaf61cmx 87 14 a a DT cord-348746-yaf61cmx 87 15 cat cat NN cord-348746-yaf61cmx 87 16 with with IN cord-348746-yaf61cmx 87 17 positive positive JJ cord-348746-yaf61cmx 87 18 immunohistochemical immunohistochemical JJ cord-348746-yaf61cmx 87 19 staining staining NN cord-348746-yaf61cmx 87 20 for for IN cord-348746-yaf61cmx 87 21 FIPV FIPV NNS cord-348746-yaf61cmx 87 22 in in IN cord-348746-yaf61cmx 87 23 monocytes monocyte NNS cord-348746-yaf61cmx 87 24 in in IN cord-348746-yaf61cmx 87 25 blood blood NN cord-348746-yaf61cmx 87 26 vessels vessel NNS cord-348746-yaf61cmx 87 27 of of IN cord-348746-yaf61cmx 87 28 the the DT cord-348746-yaf61cmx 87 29 choroid choroid JJ cord-348746-yaf61cmx 87 30 plexus plexus NN cord-348746-yaf61cmx 87 31 . . . cord-348746-yaf61cmx 88 1 36 36 CD cord-348746-yaf61cmx 89 1 Once once RB cord-348746-yaf61cmx 89 2 in in IN cord-348746-yaf61cmx 89 3 the the DT cord-348746-yaf61cmx 89 4 CNS CNS NNP cord-348746-yaf61cmx 89 5 , , , cord-348746-yaf61cmx 89 6 there there EX cord-348746-yaf61cmx 89 7 is be VBZ cord-348746-yaf61cmx 89 8 little little JJ cord-348746-yaf61cmx 89 9 evidence evidence NN cord-348746-yaf61cmx 89 10 that that IN cord-348746-yaf61cmx 89 11 FIPV FIPV NNP cord-348746-yaf61cmx 89 12 enters enter VBZ cord-348746-yaf61cmx 89 13 any any DT cord-348746-yaf61cmx 89 14 cells cell NNS cord-348746-yaf61cmx 89 15 other other JJ cord-348746-yaf61cmx 89 16 than than IN cord-348746-yaf61cmx 89 17 macrophages macrophage NNS cord-348746-yaf61cmx 89 18 . . . cord-348746-yaf61cmx 90 1 Foley Foley NNP cord-348746-yaf61cmx 90 2 et et NNP cord-348746-yaf61cmx 90 3 al al NNP cord-348746-yaf61cmx 90 4 15 15 CD cord-348746-yaf61cmx 90 5 reported report VBD cord-348746-yaf61cmx 90 6 positive positive JJ cord-348746-yaf61cmx 90 7 immunohistochemical immunohistochemical JJ cord-348746-yaf61cmx 90 8 staining staining NN cord-348746-yaf61cmx 90 9 ( ( -LRB- cord-348746-yaf61cmx 90 10 by by IN cord-348746-yaf61cmx 90 11 means mean NNS cord-348746-yaf61cmx 90 12 of of IN cord-348746-yaf61cmx 90 13 a a DT cord-348746-yaf61cmx 90 14 mouse mouse NN cord-348746-yaf61cmx 90 15 monoclonal monoclonal JJ cord-348746-yaf61cmx 90 16 antibody antibody NN cord-348746-yaf61cmx 90 17 against against IN cord-348746-yaf61cmx 90 18 the the DT cord-348746-yaf61cmx 90 19 FIPV FIPV NNP cord-348746-yaf61cmx 90 20 N N NNP cord-348746-yaf61cmx 90 21 protein protein NN cord-348746-yaf61cmx 90 22 ) ) -RRB- cord-348746-yaf61cmx 90 23 for for IN cord-348746-yaf61cmx 90 24 FIPV FIPV NNS cord-348746-yaf61cmx 90 25 , , , cord-348746-yaf61cmx 90 26 primarily primarily RB cord-348746-yaf61cmx 90 27 in in IN cord-348746-yaf61cmx 90 28 macrophages macrophage NNS cord-348746-yaf61cmx 90 29 in in IN cord-348746-yaf61cmx 90 30 FIP FIP NNP cord-348746-yaf61cmx 90 31 granulomas granuloma NNS cord-348746-yaf61cmx 90 32 but but CC cord-348746-yaf61cmx 90 33 also also RB cord-348746-yaf61cmx 90 34 in in IN cord-348746-yaf61cmx 90 35 some some DT cord-348746-yaf61cmx 90 36 lymphocytes lymphocyte NNS cord-348746-yaf61cmx 90 37 . . . cord-348746-yaf61cmx 91 1 Virus virus NN cord-348746-yaf61cmx 91 2 - - HYPH cord-348746-yaf61cmx 91 3 infected infect VBN cord-348746-yaf61cmx 91 4 cells cell NNS cord-348746-yaf61cmx 91 5 were be VBD cord-348746-yaf61cmx 91 6 numerous numerous JJ cord-348746-yaf61cmx 91 7 in in IN cord-348746-yaf61cmx 91 8 some some DT cord-348746-yaf61cmx 91 9 areas area NNS cord-348746-yaf61cmx 91 10 of of IN cord-348746-yaf61cmx 91 11 intense intense JJ cord-348746-yaf61cmx 91 12 ependymitis ependymitis NN cord-348746-yaf61cmx 91 13 and and CC cord-348746-yaf61cmx 91 14 choroiditis choroiditis NN cord-348746-yaf61cmx 91 15 and and CC cord-348746-yaf61cmx 91 16 free free JJ cord-348746-yaf61cmx 91 17 within within IN cord-348746-yaf61cmx 91 18 the the DT cord-348746-yaf61cmx 91 19 ventricular ventricular JJ cord-348746-yaf61cmx 91 20 lumen lumen NN cord-348746-yaf61cmx 91 21 , , , cord-348746-yaf61cmx 91 22 with with IN cord-348746-yaf61cmx 91 23 very very RB cord-348746-yaf61cmx 91 24 few few JJ cord-348746-yaf61cmx 91 25 positive positive JJ cord-348746-yaf61cmx 91 26 cells cell NNS cord-348746-yaf61cmx 91 27 in in IN cord-348746-yaf61cmx 91 28 the the DT cord-348746-yaf61cmx 91 29 meningeal meningeal NN cord-348746-yaf61cmx 91 30 infiltrates infiltrate VBZ cord-348746-yaf61cmx 91 31 . . . cord-348746-yaf61cmx 92 1 No no DT cord-348746-yaf61cmx 92 2 staining staining NN cord-348746-yaf61cmx 92 3 was be VBD cord-348746-yaf61cmx 92 4 observed observe VBN cord-348746-yaf61cmx 92 5 in in IN cord-348746-yaf61cmx 92 6 vascular vascular JJ cord-348746-yaf61cmx 92 7 basement basement NN cord-348746-yaf61cmx 92 8 membranes membrane NNS cord-348746-yaf61cmx 92 9 or or CC cord-348746-yaf61cmx 92 10 in in IN cord-348746-yaf61cmx 92 11 cells cell NNS cord-348746-yaf61cmx 92 12 of of IN cord-348746-yaf61cmx 92 13 the the DT cord-348746-yaf61cmx 92 14 neuropil neuropil NN cord-348746-yaf61cmx 92 15 . . . cord-348746-yaf61cmx 93 1 Macrophages macrophage NNS cord-348746-yaf61cmx 93 2 in in IN cord-348746-yaf61cmx 93 3 necrotic necrotic JJ cord-348746-yaf61cmx 93 4 regions region NNS cord-348746-yaf61cmx 93 5 and and CC cord-348746-yaf61cmx 93 6 in in IN cord-348746-yaf61cmx 93 7 the the DT cord-348746-yaf61cmx 93 8 center center NN cord-348746-yaf61cmx 93 9 of of IN cord-348746-yaf61cmx 93 10 lesions lesion NNS cord-348746-yaf61cmx 93 11 often often RB cord-348746-yaf61cmx 93 12 are be VBP cord-348746-yaf61cmx 93 13 not not RB cord-348746-yaf61cmx 93 14 infected infect VBN cord-348746-yaf61cmx 93 15 with with IN cord-348746-yaf61cmx 93 16 coronavirus coronavirus NN cord-348746-yaf61cmx 93 17 . . . cord-348746-yaf61cmx 94 1 37 37 CD cord-348746-yaf61cmx 94 2 Neurotropic Neurotropic NNP cord-348746-yaf61cmx 94 3 MHV MHV NNP cord-348746-yaf61cmx 94 4 strains strain NNS cord-348746-yaf61cmx 94 5 have have VBP cord-348746-yaf61cmx 94 6 several several JJ cord-348746-yaf61cmx 94 7 routes route NNS cord-348746-yaf61cmx 94 8 of of IN cord-348746-yaf61cmx 94 9 entry entry NN cord-348746-yaf61cmx 94 10 into into IN cord-348746-yaf61cmx 94 11 the the DT cord-348746-yaf61cmx 94 12 CNS CNS NNP cord-348746-yaf61cmx 94 13 . . . cord-348746-yaf61cmx 95 1 Some some DT cord-348746-yaf61cmx 95 2 studies study NNS cord-348746-yaf61cmx 95 3 show show VBP cord-348746-yaf61cmx 95 4 that that IN cord-348746-yaf61cmx 95 5 MHV MHV NNP cord-348746-yaf61cmx 95 6 - - HYPH cord-348746-yaf61cmx 95 7 JHM JHM NNP cord-348746-yaf61cmx 95 8 travels travel VBZ cord-348746-yaf61cmx 95 9 up up RP cord-348746-yaf61cmx 95 10 the the DT cord-348746-yaf61cmx 95 11 olfactory olfactory JJ cord-348746-yaf61cmx 95 12 nerve nerve NN cord-348746-yaf61cmx 95 13 and and CC cord-348746-yaf61cmx 95 14 enters enter VBZ cord-348746-yaf61cmx 95 15 the the DT cord-348746-yaf61cmx 95 16 CNS CNS NNP cord-348746-yaf61cmx 95 17 . . . cord-348746-yaf61cmx 96 1 38 38 CD cord-348746-yaf61cmx 97 1 This this DT cord-348746-yaf61cmx 97 2 is be VBZ cord-348746-yaf61cmx 97 3 not not RB cord-348746-yaf61cmx 97 4 surprising surprising JJ cord-348746-yaf61cmx 97 5 , , , cord-348746-yaf61cmx 97 6 because because IN cord-348746-yaf61cmx 97 7 coronaviruses coronaviruse NNS cord-348746-yaf61cmx 97 8 generally generally RB cord-348746-yaf61cmx 97 9 are be VBP cord-348746-yaf61cmx 97 10 epitheliotropic epitheliotropic JJ cord-348746-yaf61cmx 97 11 , , , cord-348746-yaf61cmx 97 12 and and CC cord-348746-yaf61cmx 97 13 neurons neuron NNS cord-348746-yaf61cmx 97 14 share share VBP cord-348746-yaf61cmx 97 15 embryological embryological JJ cord-348746-yaf61cmx 97 16 origin origin NN cord-348746-yaf61cmx 97 17 with with IN cord-348746-yaf61cmx 97 18 epithelial epithelial JJ cord-348746-yaf61cmx 97 19 cells cell NNS cord-348746-yaf61cmx 97 20 . . . cord-348746-yaf61cmx 98 1 CNS CNS NNP cord-348746-yaf61cmx 98 2 infection infection NN cord-348746-yaf61cmx 98 3 with with IN cord-348746-yaf61cmx 98 4 JHM JHM NNP cord-348746-yaf61cmx 98 5 also also RB cord-348746-yaf61cmx 98 6 may may MD cord-348746-yaf61cmx 98 7 occur occur VB cord-348746-yaf61cmx 98 8 after after IN cord-348746-yaf61cmx 98 9 peripheral peripheral JJ cord-348746-yaf61cmx 98 10 infection infection NN cord-348746-yaf61cmx 98 11 and and CC cord-348746-yaf61cmx 98 12 viremia viremia NN cord-348746-yaf61cmx 98 13 . . . cord-348746-yaf61cmx 99 1 39 39 CD cord-348746-yaf61cmx 99 2 , , , cord-348746-yaf61cmx 99 3 40 40 CD cord-348746-yaf61cmx 99 4 Receptors receptor NNS cord-348746-yaf61cmx 99 5 for for IN cord-348746-yaf61cmx 99 6 neurotropic neurotropic NNP cord-348746-yaf61cmx 99 7 human human JJ cord-348746-yaf61cmx 99 8 coronavirus coronavirus NN cord-348746-yaf61cmx 100 1 HCV-229E HCV-229E NNP cord-348746-yaf61cmx 100 2 have have VBP cord-348746-yaf61cmx 100 3 been be VBN cord-348746-yaf61cmx 100 4 detected detect VBN cord-348746-yaf61cmx 100 5 not not RB cord-348746-yaf61cmx 100 6 only only RB cord-348746-yaf61cmx 100 7 in in IN cord-348746-yaf61cmx 100 8 human human JJ cord-348746-yaf61cmx 100 9 lung lung NN cord-348746-yaf61cmx 100 10 cells cell NNS cord-348746-yaf61cmx 100 11 but but CC cord-348746-yaf61cmx 100 12 also also RB cord-348746-yaf61cmx 100 13 in in IN cord-348746-yaf61cmx 100 14 human human JJ cord-348746-yaf61cmx 100 15 neuron neuron NN cord-348746-yaf61cmx 100 16 , , , cord-348746-yaf61cmx 100 17 astrocyte astrocyte NNP cord-348746-yaf61cmx 100 18 , , , cord-348746-yaf61cmx 100 19 and and CC cord-348746-yaf61cmx 100 20 oligodendrocyte oligodendrocyte JJ cord-348746-yaf61cmx 100 21 cell cell NN cord-348746-yaf61cmx 100 22 cultures culture NNS cord-348746-yaf61cmx 100 23 . . . cord-348746-yaf61cmx 101 1 41 41 CD cord-348746-yaf61cmx 102 1 HCV-229E HCV-229E NNP cord-348746-yaf61cmx 102 2 also also RB cord-348746-yaf61cmx 102 3 infects infect VBZ cord-348746-yaf61cmx 102 4 macrophages macrophage NNS cord-348746-yaf61cmx 102 5 and and CC cord-348746-yaf61cmx 102 6 endothelial endothelial JJ cord-348746-yaf61cmx 102 7 cells cell NNS cord-348746-yaf61cmx 102 8 , , , cord-348746-yaf61cmx 102 9 however however RB cord-348746-yaf61cmx 102 10 , , , cord-348746-yaf61cmx 102 11 suggesting suggest VBG cord-348746-yaf61cmx 102 12 hematogenous hematogenous JJ cord-348746-yaf61cmx 102 13 introduction introduction NN cord-348746-yaf61cmx 102 14 into into IN cord-348746-yaf61cmx 102 15 the the DT cord-348746-yaf61cmx 102 16 CNS CNS NNP cord-348746-yaf61cmx 102 17 , , , cord-348746-yaf61cmx 102 18 40 40 CD cord-348746-yaf61cmx 102 19 , , , cord-348746-yaf61cmx 102 20 42 42 CD cord-348746-yaf61cmx 102 21 similar similar JJ cord-348746-yaf61cmx 102 22 to to IN cord-348746-yaf61cmx 102 23 FIP FIP NNP cord-348746-yaf61cmx 102 24 . . . cord-348746-yaf61cmx 103 1 Once once IN cord-348746-yaf61cmx 103 2 inside inside IN cord-348746-yaf61cmx 103 3 the the DT cord-348746-yaf61cmx 103 4 CNS CNS NNP cord-348746-yaf61cmx 103 5 , , , cord-348746-yaf61cmx 103 6 the the DT cord-348746-yaf61cmx 103 7 major major JJ cord-348746-yaf61cmx 103 8 targets target NNS cord-348746-yaf61cmx 103 9 for for IN cord-348746-yaf61cmx 103 10 MHV MHV NNP cord-348746-yaf61cmx 103 11 are be VBP cord-348746-yaf61cmx 103 12 glial glial JJ cord-348746-yaf61cmx 103 13 cells cell NNS cord-348746-yaf61cmx 103 14 and and CC cord-348746-yaf61cmx 103 15 neurons neuron NNS cord-348746-yaf61cmx 103 16 . . . cord-348746-yaf61cmx 104 1 35 35 CD cord-348746-yaf61cmx 104 2 Especially especially RB cord-348746-yaf61cmx 104 3 in in IN cord-348746-yaf61cmx 104 4 neuroattenuated neuroattenuated JJ cord-348746-yaf61cmx 104 5 strains strain NNS cord-348746-yaf61cmx 104 6 , , , cord-348746-yaf61cmx 104 7 MHV MHV NNP cord-348746-yaf61cmx 104 8 - - HYPH cord-348746-yaf61cmx 104 9 JHM JHM NNP cord-348746-yaf61cmx 104 10 infects infect VBZ cord-348746-yaf61cmx 104 11 primarily primarily RB cord-348746-yaf61cmx 104 12 oligodendrocytes oligodendrocyte NNS cord-348746-yaf61cmx 104 13 43 43 CD cord-348746-yaf61cmx 104 14 and and CC cord-348746-yaf61cmx 104 15 has have VBZ cord-348746-yaf61cmx 104 16 been be VBN cord-348746-yaf61cmx 104 17 reported report VBN cord-348746-yaf61cmx 104 18 in in IN cord-348746-yaf61cmx 104 19 astrocytes astrocyte NNS cord-348746-yaf61cmx 104 20 . . . cord-348746-yaf61cmx 105 1 44 44 CD cord-348746-yaf61cmx 105 2 MHV-4 MHV-4 NNP cord-348746-yaf61cmx 105 3 infects infect VBZ cord-348746-yaf61cmx 105 4 mainly mainly RB cord-348746-yaf61cmx 105 5 neurons neuron NNS cord-348746-yaf61cmx 105 6 . . . cord-348746-yaf61cmx 106 1 20 20 CD cord-348746-yaf61cmx 107 1 Subsequent subsequent JJ cord-348746-yaf61cmx 107 2 events event NNS cord-348746-yaf61cmx 107 3 in in IN cord-348746-yaf61cmx 107 4 chronic chronic JJ cord-348746-yaf61cmx 107 5 disease disease NN cord-348746-yaf61cmx 107 6 pathogenesis pathogenesis NN cord-348746-yaf61cmx 107 7 include include VBP cord-348746-yaf61cmx 107 8 recruitment recruitment NN cord-348746-yaf61cmx 107 9 of of IN cord-348746-yaf61cmx 107 10 inflammatory inflammatory JJ cord-348746-yaf61cmx 107 11 cells cell NNS cord-348746-yaf61cmx 107 12 and and CC cord-348746-yaf61cmx 107 13 the the DT cord-348746-yaf61cmx 107 14 interactions interaction NNS cord-348746-yaf61cmx 107 15 of of IN cord-348746-yaf61cmx 107 16 immune immune JJ cord-348746-yaf61cmx 107 17 cells cell NNS cord-348746-yaf61cmx 107 18 with with IN cord-348746-yaf61cmx 107 19 the the DT cord-348746-yaf61cmx 107 20 virus virus NN cord-348746-yaf61cmx 107 21 - - HYPH cord-348746-yaf61cmx 107 22 infected infect VBN cord-348746-yaf61cmx 107 23 cells cell NNS cord-348746-yaf61cmx 107 24 . . . cord-348746-yaf61cmx 108 1 Macrophages macrophage NNS cord-348746-yaf61cmx 108 2 , , , cord-348746-yaf61cmx 108 3 activated activate VBD cord-348746-yaf61cmx 108 4 T t NN cord-348746-yaf61cmx 108 5 - - HYPH cord-348746-yaf61cmx 108 6 cells cell NNS cord-348746-yaf61cmx 108 7 , , , cord-348746-yaf61cmx 108 8 and and CC cord-348746-yaf61cmx 108 9 some some DT cord-348746-yaf61cmx 108 10 B b NN cord-348746-yaf61cmx 108 11 - - HYPH cord-348746-yaf61cmx 108 12 cells cell NNS cord-348746-yaf61cmx 108 13 may may MD cord-348746-yaf61cmx 108 14 cross cross VB cord-348746-yaf61cmx 108 15 into into IN cord-348746-yaf61cmx 108 16 the the DT cord-348746-yaf61cmx 108 17 intact intact JJ cord-348746-yaf61cmx 108 18 CNS cns NN cord-348746-yaf61cmx 108 19 through through IN cord-348746-yaf61cmx 108 20 the the DT cord-348746-yaf61cmx 108 21 blood blood NN cord-348746-yaf61cmx 108 22 - - HYPH cord-348746-yaf61cmx 108 23 brain brain NN cord-348746-yaf61cmx 108 24 barrier barrier NN cord-348746-yaf61cmx 108 25 , , , cord-348746-yaf61cmx 108 26 with with IN cord-348746-yaf61cmx 108 27 the the DT cord-348746-yaf61cmx 108 28 potential potential NN cord-348746-yaf61cmx 108 29 for for IN cord-348746-yaf61cmx 108 30 major major JJ cord-348746-yaf61cmx 108 31 cytokine cytokine NN cord-348746-yaf61cmx 108 32 upregulation upregulation NN cord-348746-yaf61cmx 108 33 . . . cord-348746-yaf61cmx 109 1 45 45 CD cord-348746-yaf61cmx 109 2 , , , cord-348746-yaf61cmx 109 3 46 46 CD cord-348746-yaf61cmx 110 1 The the DT cord-348746-yaf61cmx 110 2 Immunopathogenesis Immunopathogenesis NNP cord-348746-yaf61cmx 110 3 of of IN cord-348746-yaf61cmx 110 4 Neurologic Neurologic NNP cord-348746-yaf61cmx 110 5 Coronavirus Coronavirus NNP cord-348746-yaf61cmx 110 6 Infections Infections NNPS cord-348746-yaf61cmx 111 1 After after IN cord-348746-yaf61cmx 111 2 establishment establishment NN cord-348746-yaf61cmx 111 3 of of IN cord-348746-yaf61cmx 111 4 FIPV FIPV NNS cord-348746-yaf61cmx 111 5 in in IN cord-348746-yaf61cmx 111 6 the the DT cord-348746-yaf61cmx 111 7 CNS CNS NNP cord-348746-yaf61cmx 111 8 , , , cord-348746-yaf61cmx 111 9 mechanisms mechanism NNS cord-348746-yaf61cmx 111 10 of of IN cord-348746-yaf61cmx 111 11 disease disease NN cord-348746-yaf61cmx 111 12 are be VBP cord-348746-yaf61cmx 111 13 primarily primarily RB cord-348746-yaf61cmx 111 14 immune immune JJ cord-348746-yaf61cmx 111 15 - - HYPH cord-348746-yaf61cmx 111 16 mediated mediate VBN cord-348746-yaf61cmx 111 17 , , , cord-348746-yaf61cmx 111 18 involving involve VBG cord-348746-yaf61cmx 111 19 humoral humoral JJ cord-348746-yaf61cmx 111 20 and and CC cord-348746-yaf61cmx 111 21 cell cell NN cord-348746-yaf61cmx 111 22 - - HYPH cord-348746-yaf61cmx 111 23 mediated mediate VBN cord-348746-yaf61cmx 111 24 immunity immunity NN cord-348746-yaf61cmx 111 25 ( ( -LRB- cord-348746-yaf61cmx 111 26 CMI CMI NNP cord-348746-yaf61cmx 111 27 ) ) -RRB- cord-348746-yaf61cmx 111 28 . . . cord-348746-yaf61cmx 112 1 Coronavirus Coronavirus NNP cord-348746-yaf61cmx 112 2 - - HYPH cord-348746-yaf61cmx 112 3 infected infect VBN cord-348746-yaf61cmx 112 4 macrophages macrophage NNS cord-348746-yaf61cmx 112 5 can can MD cord-348746-yaf61cmx 112 6 trigger trigger VB cord-348746-yaf61cmx 112 7 massive massive JJ cord-348746-yaf61cmx 112 8 complement complement NN cord-348746-yaf61cmx 112 9 activation activation NN cord-348746-yaf61cmx 112 10 and and CC cord-348746-yaf61cmx 112 11 deposition deposition NN cord-348746-yaf61cmx 112 12 of of IN cord-348746-yaf61cmx 112 13 C3 C3 NNP cord-348746-yaf61cmx 112 14 on on IN cord-348746-yaf61cmx 112 15 affected affected JJ cord-348746-yaf61cmx 112 16 surfaces surface NNS cord-348746-yaf61cmx 112 17 , , , cord-348746-yaf61cmx 112 18 disseminated disseminate VBN cord-348746-yaf61cmx 112 19 intravascular intravascular JJ cord-348746-yaf61cmx 112 20 coagulopathy coagulopathy NN cord-348746-yaf61cmx 112 21 , , , cord-348746-yaf61cmx 112 22 vessel vessel NN cord-348746-yaf61cmx 112 23 necrosis necrosis NN cord-348746-yaf61cmx 112 24 , , , cord-348746-yaf61cmx 112 25 and and CC cord-348746-yaf61cmx 112 26 effusion effusion NN cord-348746-yaf61cmx 112 27 . . . cord-348746-yaf61cmx 113 1 37 37 CD cord-348746-yaf61cmx 113 2 , , , cord-348746-yaf61cmx 113 3 [ [ -LRB- cord-348746-yaf61cmx 113 4 47 47 CD cord-348746-yaf61cmx 113 5 ] ] -RRB- cord-348746-yaf61cmx 113 6 [ [ -LRB- cord-348746-yaf61cmx 113 7 48 48 CD cord-348746-yaf61cmx 113 8 ] ] -RRB- cord-348746-yaf61cmx 113 9 [ [ -LRB- cord-348746-yaf61cmx 113 10 49 49 CD cord-348746-yaf61cmx 113 11 ] ] -RRB- cord-348746-yaf61cmx 114 1 However however RB cord-348746-yaf61cmx 114 2 , , , cord-348746-yaf61cmx 114 3 immunopathogenic immunopathogenic JJ cord-348746-yaf61cmx 114 4 events event NNS cord-348746-yaf61cmx 114 5 in in IN cord-348746-yaf61cmx 114 6 neurological neurological JJ cord-348746-yaf61cmx 114 7 FIP FIP NNP cord-348746-yaf61cmx 114 8 have have VBP cord-348746-yaf61cmx 114 9 not not RB cord-348746-yaf61cmx 114 10 been be VBN cord-348746-yaf61cmx 114 11 well well RB cord-348746-yaf61cmx 114 12 described describe VBN cord-348746-yaf61cmx 114 13 . . . cord-348746-yaf61cmx 115 1 Both both DT cord-348746-yaf61cmx 115 2 in in IN cord-348746-yaf61cmx 115 3 systemic systemic JJ cord-348746-yaf61cmx 115 4 and and CC cord-348746-yaf61cmx 115 5 neurological neurological JJ cord-348746-yaf61cmx 115 6 FIP fip NN cord-348746-yaf61cmx 115 7 , , , cord-348746-yaf61cmx 115 8 antibodies antibody NNS cord-348746-yaf61cmx 115 9 ( ( -LRB- cord-348746-yaf61cmx 115 10 especially especially RB cord-348746-yaf61cmx 115 11 to to IN cord-348746-yaf61cmx 115 12 the the DT cord-348746-yaf61cmx 115 13 spike spike NN cord-348746-yaf61cmx 115 14 protein protein NN cord-348746-yaf61cmx 115 15 ) ) -RRB- cord-348746-yaf61cmx 115 16 contribute contribute VBP cord-348746-yaf61cmx 115 17 to to IN cord-348746-yaf61cmx 115 18 the the DT cord-348746-yaf61cmx 115 19 opsonization opsonization NN cord-348746-yaf61cmx 115 20 of of IN cord-348746-yaf61cmx 115 21 viral viral JJ cord-348746-yaf61cmx 115 22 antigen antigen NN cord-348746-yaf61cmx 115 23 and and CC cord-348746-yaf61cmx 115 24 have have VB cord-348746-yaf61cmx 115 25 the the DT cord-348746-yaf61cmx 115 26 capacity capacity NN cord-348746-yaf61cmx 115 27 to to TO cord-348746-yaf61cmx 115 28 mediate mediate VB cord-348746-yaf61cmx 115 29 or or CC cord-348746-yaf61cmx 115 30 enhance enhance VB cord-348746-yaf61cmx 115 31 disease disease NN cord-348746-yaf61cmx 115 32 . . . cord-348746-yaf61cmx 116 1 [ [ -LRB- cord-348746-yaf61cmx 116 2 50 50 CD cord-348746-yaf61cmx 116 3 ] ] -RRB- cord-348746-yaf61cmx 116 4 [ [ -LRB- cord-348746-yaf61cmx 116 5 51 51 CD cord-348746-yaf61cmx 116 6 ] ] -RRB- cord-348746-yaf61cmx 117 1 [ [ -LRB- cord-348746-yaf61cmx 117 2 52 52 CD cord-348746-yaf61cmx 117 3 ] ] -RRB- cord-348746-yaf61cmx 118 1 [ [ -LRB- cord-348746-yaf61cmx 118 2 53 53 CD cord-348746-yaf61cmx 118 3 ] ] -RRB- cord-348746-yaf61cmx 118 4 [ [ -LRB- cord-348746-yaf61cmx 118 5 54 54 CD cord-348746-yaf61cmx 118 6 ] ] -RRB- cord-348746-yaf61cmx 119 1 Antibodies antibody NNS cord-348746-yaf61cmx 119 2 to to IN cord-348746-yaf61cmx 119 3 FECV FECV NNP cord-348746-yaf61cmx 119 4 and and CC cord-348746-yaf61cmx 119 5 FIPV FIPV NNS cord-348746-yaf61cmx 119 6 are be VBP cord-348746-yaf61cmx 119 7 identical identical JJ cord-348746-yaf61cmx 119 8 . . . cord-348746-yaf61cmx 120 1 Anti Anti NNP cord-348746-yaf61cmx 120 2 - - NNP cord-348746-yaf61cmx 120 3 FIPV FIPV NNP cord-348746-yaf61cmx 120 4 IgG igg NN cord-348746-yaf61cmx 120 5 and and CC cord-348746-yaf61cmx 120 6 IgM IgM NNP cord-348746-yaf61cmx 120 7 - - HYPH cord-348746-yaf61cmx 120 8 producing produce VBG cord-348746-yaf61cmx 120 9 B b NN cord-348746-yaf61cmx 120 10 - - HYPH cord-348746-yaf61cmx 120 11 cells cell NNS cord-348746-yaf61cmx 120 12 are be VBP cord-348746-yaf61cmx 120 13 present present JJ cord-348746-yaf61cmx 120 14 in in IN cord-348746-yaf61cmx 120 15 FIP FIP NNP cord-348746-yaf61cmx 120 16 lesions lesion NNS cord-348746-yaf61cmx 120 17 , , , cord-348746-yaf61cmx 120 18 at at IN cord-348746-yaf61cmx 120 19 the the DT cord-348746-yaf61cmx 120 20 interface interface NN cord-348746-yaf61cmx 120 21 of of IN cord-348746-yaf61cmx 120 22 healthy healthy JJ cord-348746-yaf61cmx 120 23 tissue tissue NN cord-348746-yaf61cmx 120 24 and and CC cord-348746-yaf61cmx 120 25 granulomas granuloma NNS cord-348746-yaf61cmx 120 26 , , , cord-348746-yaf61cmx 120 27 and and CC cord-348746-yaf61cmx 120 28 in in IN cord-348746-yaf61cmx 120 29 the the DT cord-348746-yaf61cmx 120 30 serum serum NN cord-348746-yaf61cmx 120 31 and and CC cord-348746-yaf61cmx 120 32 CSF CSF NNP cord-348746-yaf61cmx 120 33 of of IN cord-348746-yaf61cmx 120 34 cats cat NNS cord-348746-yaf61cmx 120 35 with with IN cord-348746-yaf61cmx 120 36 neurological neurological JJ cord-348746-yaf61cmx 120 37 FIP fip NN cord-348746-yaf61cmx 120 38 . . . cord-348746-yaf61cmx 121 1 26 26 CD cord-348746-yaf61cmx 121 2 , , , cord-348746-yaf61cmx 121 3 37 37 CD cord-348746-yaf61cmx 121 4 Apparently apparently RB cord-348746-yaf61cmx 121 5 , , , cord-348746-yaf61cmx 121 6 some some DT cord-348746-yaf61cmx 121 7 antibody antibody NN cord-348746-yaf61cmx 121 8 production production NN cord-348746-yaf61cmx 121 9 occurs occur VBZ cord-348746-yaf61cmx 121 10 locally locally RB cord-348746-yaf61cmx 121 11 in in IN cord-348746-yaf61cmx 121 12 the the DT cord-348746-yaf61cmx 121 13 CNS CNS NNP cord-348746-yaf61cmx 121 14 , , , cord-348746-yaf61cmx 121 15 in in IN cord-348746-yaf61cmx 121 16 response response NN cord-348746-yaf61cmx 121 17 to to IN cord-348746-yaf61cmx 121 18 viral viral JJ cord-348746-yaf61cmx 121 19 antigen antigen NN cord-348746-yaf61cmx 121 20 in in IN cord-348746-yaf61cmx 121 21 the the DT cord-348746-yaf61cmx 121 22 brain brain NN cord-348746-yaf61cmx 121 23 . . . cord-348746-yaf61cmx 122 1 In in IN cord-348746-yaf61cmx 122 2 one one CD cord-348746-yaf61cmx 122 3 study study NN cord-348746-yaf61cmx 122 4 , , , cord-348746-yaf61cmx 122 5 serum serum NN cord-348746-yaf61cmx 122 6 coronavirus coronavirus NN cord-348746-yaf61cmx 122 7 titers titer NNS cord-348746-yaf61cmx 122 8 of of IN cord-348746-yaf61cmx 122 9 16 16 CD cord-348746-yaf61cmx 122 10 cats cat NNS cord-348746-yaf61cmx 122 11 with with IN cord-348746-yaf61cmx 122 12 neurological neurological JJ cord-348746-yaf61cmx 122 13 FIP FIP NNP cord-348746-yaf61cmx 122 14 were be VBD cord-348746-yaf61cmx 122 15 positive positive JJ cord-348746-yaf61cmx 122 16 , , , cord-348746-yaf61cmx 122 17 with with IN cord-348746-yaf61cmx 122 18 a a DT cord-348746-yaf61cmx 122 19 median median JJ cord-348746-yaf61cmx 122 20 titer titer NN cord-348746-yaf61cmx 122 21 of of IN cord-348746-yaf61cmx 122 22 1 1 CD cord-348746-yaf61cmx 122 23 : : SYM cord-348746-yaf61cmx 122 24 400 400 CD cord-348746-yaf61cmx 122 25 , , , cord-348746-yaf61cmx 122 26 whereas whereas IN cord-348746-yaf61cmx 122 27 CSF csf NN cord-348746-yaf61cmx 122 28 titers titer NNS cord-348746-yaf61cmx 122 29 were be VBD cord-348746-yaf61cmx 122 30 positive positive JJ cord-348746-yaf61cmx 122 31 in in IN cord-348746-yaf61cmx 122 32 15 15 CD cord-348746-yaf61cmx 122 33 cats cat NNS cord-348746-yaf61cmx 122 34 , , , cord-348746-yaf61cmx 122 35 with with IN cord-348746-yaf61cmx 122 36 a a DT cord-348746-yaf61cmx 122 37 median median JJ cord-348746-yaf61cmx 122 38 titer titer NN cord-348746-yaf61cmx 122 39 of of IN cord-348746-yaf61cmx 122 40 1 1 CD cord-348746-yaf61cmx 122 41 : : SYM cord-348746-yaf61cmx 122 42 100 100 CD cord-348746-yaf61cmx 122 43 . . . cord-348746-yaf61cmx 123 1 15 15 CD cord-348746-yaf61cmx 123 2 Two two CD cord-348746-yaf61cmx 123 3 cats cat NNS cord-348746-yaf61cmx 123 4 had have VBD cord-348746-yaf61cmx 123 5 high high JJ cord-348746-yaf61cmx 123 6 protein protein NN cord-348746-yaf61cmx 123 7 concentrations concentration NNS cord-348746-yaf61cmx 123 8 and and CC cord-348746-yaf61cmx 123 9 increased increase VBN cord-348746-yaf61cmx 123 10 cells cell NNS cord-348746-yaf61cmx 123 11 , , , cord-348746-yaf61cmx 123 12 predominantly predominantly RB cord-348746-yaf61cmx 123 13 lymphocytes lymphocyte NNS cord-348746-yaf61cmx 123 14 and and CC cord-348746-yaf61cmx 123 15 neutrophils neutrophil NNS cord-348746-yaf61cmx 123 16 . . . cord-348746-yaf61cmx 124 1 The the DT cord-348746-yaf61cmx 124 2 titer titer NN cord-348746-yaf61cmx 124 3 in in IN cord-348746-yaf61cmx 124 4 CSF CSF NNP cord-348746-yaf61cmx 124 5 was be VBD cord-348746-yaf61cmx 124 6 not not RB cord-348746-yaf61cmx 124 7 statistically statistically RB cord-348746-yaf61cmx 124 8 correlated correlate VBN cord-348746-yaf61cmx 124 9 with with IN cord-348746-yaf61cmx 124 10 serum serum NN cord-348746-yaf61cmx 124 11 titer titer NN cord-348746-yaf61cmx 124 12 , , , cord-348746-yaf61cmx 124 13 and and CC cord-348746-yaf61cmx 124 14 the the DT cord-348746-yaf61cmx 124 15 ratio ratio NN cord-348746-yaf61cmx 124 16 of of IN cord-348746-yaf61cmx 124 17 serum serum NN cord-348746-yaf61cmx 124 18 : : : cord-348746-yaf61cmx 124 19 CSF CSF NNP cord-348746-yaf61cmx 124 20 titer titer NN cord-348746-yaf61cmx 124 21 was be VBD cord-348746-yaf61cmx 124 22 not not RB cord-348746-yaf61cmx 124 23 correlated correlate VBN cord-348746-yaf61cmx 124 24 with with IN cord-348746-yaf61cmx 124 25 the the DT cord-348746-yaf61cmx 124 26 serum serum NN cord-348746-yaf61cmx 124 27 : : : cord-348746-yaf61cmx 124 28 CSF csf NN cord-348746-yaf61cmx 124 29 protein protein NN cord-348746-yaf61cmx 124 30 ratio ratio NN cord-348746-yaf61cmx 124 31 . . . cord-348746-yaf61cmx 125 1 If if IN cord-348746-yaf61cmx 125 2 passive passive JJ cord-348746-yaf61cmx 125 3 leakage leakage NN cord-348746-yaf61cmx 125 4 of of IN cord-348746-yaf61cmx 125 5 protein protein NN cord-348746-yaf61cmx 125 6 from from IN cord-348746-yaf61cmx 125 7 serum serum NN cord-348746-yaf61cmx 125 8 into into IN cord-348746-yaf61cmx 125 9 the the DT cord-348746-yaf61cmx 125 10 CSF CSF NNP cord-348746-yaf61cmx 125 11 were be VBD cord-348746-yaf61cmx 125 12 invoked invoke VBN cord-348746-yaf61cmx 125 13 to to TO cord-348746-yaf61cmx 125 14 explain explain VB cord-348746-yaf61cmx 125 15 the the DT cord-348746-yaf61cmx 125 16 presence presence NN cord-348746-yaf61cmx 125 17 of of IN cord-348746-yaf61cmx 125 18 antibodies antibody NNS cord-348746-yaf61cmx 125 19 , , , cord-348746-yaf61cmx 125 20 it -PRON- PRP cord-348746-yaf61cmx 125 21 would would MD cord-348746-yaf61cmx 125 22 be be VB cord-348746-yaf61cmx 125 23 expected expect VBN cord-348746-yaf61cmx 125 24 that that IN cord-348746-yaf61cmx 125 25 the the DT cord-348746-yaf61cmx 125 26 total total JJ cord-348746-yaf61cmx 125 27 protein protein NN cord-348746-yaf61cmx 125 28 : : : cord-348746-yaf61cmx 126 1 anti anti NNP cord-348746-yaf61cmx 126 2 - - NNP cord-348746-yaf61cmx 126 3 FIPV fipv JJ cord-348746-yaf61cmx 126 4 IgG igg NN cord-348746-yaf61cmx 126 5 ratios ratio NNS cord-348746-yaf61cmx 126 6 would would MD cord-348746-yaf61cmx 126 7 be be VB cord-348746-yaf61cmx 126 8 similar similar JJ cord-348746-yaf61cmx 126 9 in in IN cord-348746-yaf61cmx 126 10 both both DT cord-348746-yaf61cmx 126 11 serum serum NN cord-348746-yaf61cmx 126 12 and and CC cord-348746-yaf61cmx 126 13 CSF CSF NNP cord-348746-yaf61cmx 126 14 . . . cord-348746-yaf61cmx 127 1 In in IN cord-348746-yaf61cmx 127 2 contrast contrast NN cord-348746-yaf61cmx 127 3 , , , cord-348746-yaf61cmx 127 4 CSF CSF NNP cord-348746-yaf61cmx 127 5 IgG igg NN cord-348746-yaf61cmx 127 6 titers titer NNS cord-348746-yaf61cmx 127 7 tended tend VBD cord-348746-yaf61cmx 127 8 to to TO cord-348746-yaf61cmx 127 9 be be VB cord-348746-yaf61cmx 127 10 proportionally proportionally RB cord-348746-yaf61cmx 127 11 much much RB cord-348746-yaf61cmx 127 12 higher high JJR cord-348746-yaf61cmx 127 13 than than IN cord-348746-yaf61cmx 127 14 serum serum NN cord-348746-yaf61cmx 127 15 titers titer NNS cord-348746-yaf61cmx 127 16 . . . cord-348746-yaf61cmx 128 1 This this DT cord-348746-yaf61cmx 128 2 finding finding NN cord-348746-yaf61cmx 128 3 suggests suggest VBZ cord-348746-yaf61cmx 128 4 that that IN cord-348746-yaf61cmx 128 5 anti anti JJ cord-348746-yaf61cmx 128 6 - - NNP cord-348746-yaf61cmx 128 7 FIPV FIPV NNP cord-348746-yaf61cmx 128 8 IgG igg NN cord-348746-yaf61cmx 128 9 may may MD cord-348746-yaf61cmx 128 10 have have VB cord-348746-yaf61cmx 128 11 been be VBN cord-348746-yaf61cmx 128 12 produced produce VBN cord-348746-yaf61cmx 128 13 in in IN cord-348746-yaf61cmx 128 14 the the DT cord-348746-yaf61cmx 128 15 tissues tissue NNS cord-348746-yaf61cmx 128 16 of of IN cord-348746-yaf61cmx 128 17 the the DT cord-348746-yaf61cmx 128 18 brain brain NN cord-348746-yaf61cmx 128 19 in in IN cord-348746-yaf61cmx 128 20 response response NN cord-348746-yaf61cmx 128 21 to to IN cord-348746-yaf61cmx 128 22 a a DT cord-348746-yaf61cmx 128 23 locally locally RB cord-348746-yaf61cmx 128 24 replicating replicate VBG cord-348746-yaf61cmx 128 25 virus virus NN cord-348746-yaf61cmx 128 26 . . . cord-348746-yaf61cmx 129 1 Although although IN cord-348746-yaf61cmx 129 2 almost almost RB cord-348746-yaf61cmx 129 3 nothing nothing NN cord-348746-yaf61cmx 129 4 is be VBZ cord-348746-yaf61cmx 129 5 known know VBN cord-348746-yaf61cmx 129 6 about about IN cord-348746-yaf61cmx 129 7 the the DT cord-348746-yaf61cmx 129 8 mechanism mechanism NN cord-348746-yaf61cmx 129 9 , , , cord-348746-yaf61cmx 129 10 cell cell NN cord-348746-yaf61cmx 129 11 - - HYPH cord-348746-yaf61cmx 129 12 mediated mediate VBN cord-348746-yaf61cmx 129 13 immunity immunity NN cord-348746-yaf61cmx 129 14 has have VBZ cord-348746-yaf61cmx 129 15 been be VBN cord-348746-yaf61cmx 129 16 hypothesized hypothesize VBN cord-348746-yaf61cmx 129 17 to to TO cord-348746-yaf61cmx 129 18 be be VB cord-348746-yaf61cmx 129 19 protective protective JJ cord-348746-yaf61cmx 129 20 against against IN cord-348746-yaf61cmx 129 21 FIP FIP NNP cord-348746-yaf61cmx 129 22 . . . cord-348746-yaf61cmx 130 1 [ [ -LRB- cord-348746-yaf61cmx 130 2 50 50 CD cord-348746-yaf61cmx 130 3 ] ] -RRB- cord-348746-yaf61cmx 130 4 [ [ -LRB- cord-348746-yaf61cmx 130 5 51 51 CD cord-348746-yaf61cmx 130 6 ] ] -RRB- cord-348746-yaf61cmx 130 7 [ [ -LRB- cord-348746-yaf61cmx 130 8 52 52 CD cord-348746-yaf61cmx 130 9 ] ] -RRB- cord-348746-yaf61cmx 131 1 [ [ -LRB- cord-348746-yaf61cmx 131 2 53 53 CD cord-348746-yaf61cmx 131 3 ] ] -RRB- cord-348746-yaf61cmx 131 4 [ [ -LRB- cord-348746-yaf61cmx 131 5 54 54 CD cord-348746-yaf61cmx 131 6 ] ] -RRB- cord-348746-yaf61cmx 131 7 CD4ϩ CD4ϩ NNP cord-348746-yaf61cmx 131 8 T T NNP cord-348746-yaf61cmx 131 9 - - HYPH cord-348746-yaf61cmx 131 10 cells cell NNS cord-348746-yaf61cmx 131 11 commonly commonly RB cord-348746-yaf61cmx 131 12 are be VBP cord-348746-yaf61cmx 131 13 observed observe VBN cord-348746-yaf61cmx 131 14 in in IN cord-348746-yaf61cmx 131 15 FIP FIP NNP cord-348746-yaf61cmx 131 16 granulomas granuloma NNS cord-348746-yaf61cmx 131 17 . . . cord-348746-yaf61cmx 132 1 37 37 CD cord-348746-yaf61cmx 133 1 During during IN cord-348746-yaf61cmx 133 2 acute acute JJ cord-348746-yaf61cmx 133 3 experimental experimental JJ cord-348746-yaf61cmx 133 4 multisystemic multisystemic NN cord-348746-yaf61cmx 133 5 FIP fip NN cord-348746-yaf61cmx 133 6 , , , cord-348746-yaf61cmx 133 7 apoptosis apoptosis NN cord-348746-yaf61cmx 133 8 and and CC cord-348746-yaf61cmx 133 9 T t NN cord-348746-yaf61cmx 133 10 - - HYPH cord-348746-yaf61cmx 133 11 cell cell NN cord-348746-yaf61cmx 133 12 depletion depletion NN cord-348746-yaf61cmx 133 13 were be VBD cord-348746-yaf61cmx 133 14 observed observe VBN cord-348746-yaf61cmx 133 15 in in IN cord-348746-yaf61cmx 133 16 the the DT cord-348746-yaf61cmx 133 17 spleen spleen NN cord-348746-yaf61cmx 133 18 and and CC cord-348746-yaf61cmx 133 19 mesenteric mesenteric JJ cord-348746-yaf61cmx 133 20 lymph lymph NN cord-348746-yaf61cmx 133 21 nodes node NNS cord-348746-yaf61cmx 133 22 . . . cord-348746-yaf61cmx 134 1 55 55 CD cord-348746-yaf61cmx 135 1 This this DT cord-348746-yaf61cmx 135 2 effect effect NN cord-348746-yaf61cmx 135 3 was be VBD cord-348746-yaf61cmx 135 4 induced induce VBN cord-348746-yaf61cmx 135 5 by by IN cord-348746-yaf61cmx 135 6 heat heat NN cord-348746-yaf61cmx 135 7 - - HYPH cord-348746-yaf61cmx 135 8 treated treat VBN cord-348746-yaf61cmx 135 9 effusion effusion NN cord-348746-yaf61cmx 135 10 fluid fluid NN cord-348746-yaf61cmx 135 11 ( ( -LRB- cord-348746-yaf61cmx 135 12 presumably presumably RB cord-348746-yaf61cmx 135 13 containing contain VBG cord-348746-yaf61cmx 135 14 some some DT cord-348746-yaf61cmx 135 15 cytokines cytokine NNS cord-348746-yaf61cmx 135 16 ) ) -RRB- cord-348746-yaf61cmx 135 17 but but CC cord-348746-yaf61cmx 135 18 not not RB cord-348746-yaf61cmx 135 19 tissue tissue NN cord-348746-yaf61cmx 135 20 culture culture NN cord-348746-yaf61cmx 135 21 fluid fluid NN cord-348746-yaf61cmx 135 22 . . . cord-348746-yaf61cmx 136 1 Likewise likewise RB cord-348746-yaf61cmx 136 2 , , , cord-348746-yaf61cmx 136 3 little little JJ cord-348746-yaf61cmx 136 4 is be VBZ cord-348746-yaf61cmx 136 5 known know VBN cord-348746-yaf61cmx 136 6 about about IN cord-348746-yaf61cmx 136 7 the the DT cord-348746-yaf61cmx 136 8 induction induction NN cord-348746-yaf61cmx 136 9 of of IN cord-348746-yaf61cmx 136 10 cytokines cytokine NNS cord-348746-yaf61cmx 136 11 during during IN cord-348746-yaf61cmx 136 12 the the DT cord-348746-yaf61cmx 136 13 course course NN cord-348746-yaf61cmx 136 14 of of IN cord-348746-yaf61cmx 136 15 FIP FIP NNP cord-348746-yaf61cmx 136 16 . . . cord-348746-yaf61cmx 137 1 Preliminary preliminary JJ cord-348746-yaf61cmx 137 2 findings finding NNS cord-348746-yaf61cmx 137 3 suggest suggest VBP cord-348746-yaf61cmx 137 4 that that IN cord-348746-yaf61cmx 137 5 development development NN cord-348746-yaf61cmx 137 6 of of IN cord-348746-yaf61cmx 137 7 FIP FIP NNP cord-348746-yaf61cmx 137 8 appears appear VBZ cord-348746-yaf61cmx 137 9 to to TO cord-348746-yaf61cmx 137 10 be be VB cord-348746-yaf61cmx 137 11 associated associate VBN cord-348746-yaf61cmx 137 12 with with IN cord-348746-yaf61cmx 137 13 a a DT cord-348746-yaf61cmx 137 14 switch switch NN cord-348746-yaf61cmx 137 15 to to IN cord-348746-yaf61cmx 137 16 predominantly predominantly RB cord-348746-yaf61cmx 137 17 Th2 th2 CD cord-348746-yaf61cmx 137 18 immunity immunity NN cord-348746-yaf61cmx 137 19 , , , cord-348746-yaf61cmx 137 20 with with IN cord-348746-yaf61cmx 137 21 increases increase NNS cord-348746-yaf61cmx 137 22 in in IN cord-348746-yaf61cmx 137 23 IL-10 IL-10 NNP cord-348746-yaf61cmx 137 24 concentrations concentration NNS cord-348746-yaf61cmx 137 25 . . . cord-348746-yaf61cmx 138 1 56 56 CD cord-348746-yaf61cmx 139 1 Goitsuka Goitsuka NNP cord-348746-yaf61cmx 139 2 et et FW cord-348746-yaf61cmx 139 3 al al NNP cord-348746-yaf61cmx 139 4 57 57 CD cord-348746-yaf61cmx 139 5 described describe VBN cord-348746-yaf61cmx 139 6 increases increase NNS cord-348746-yaf61cmx 139 7 in in IN cord-348746-yaf61cmx 139 8 IL-6 IL-6 NNP cord-348746-yaf61cmx 139 9 and and CC cord-348746-yaf61cmx 139 10 IL-1 IL-1 NNP cord-348746-yaf61cmx 139 11 , , , cord-348746-yaf61cmx 139 12 but but CC cord-348746-yaf61cmx 139 13 Gunn Gunn NNP cord-348746-yaf61cmx 139 14 - - HYPH cord-348746-yaf61cmx 139 15 Moore Moore NNP cord-348746-yaf61cmx 139 16 et et NNP cord-348746-yaf61cmx 139 17 al al NNP cord-348746-yaf61cmx 139 18 58 58 CD cord-348746-yaf61cmx 139 19 reported report VBD cord-348746-yaf61cmx 139 20 reductions reduction NNS cord-348746-yaf61cmx 139 21 in in IN cord-348746-yaf61cmx 139 22 TH TH NNP cord-348746-yaf61cmx 139 23 2 2 CD cord-348746-yaf61cmx 139 24 and and CC cord-348746-yaf61cmx 139 25 TH TH NNP cord-348746-yaf61cmx 139 26 1 1 CD cord-348746-yaf61cmx 139 27 cytokines cytokine NNS cord-348746-yaf61cmx 139 28 including include VBG cord-348746-yaf61cmx 139 29 IL-2 IL-2 NNP cord-348746-yaf61cmx 139 30 , , , cord-348746-yaf61cmx 139 31 IL-4 IL-4 NNP cord-348746-yaf61cmx 139 32 , , , cord-348746-yaf61cmx 139 33 IL-10 IL-10 NNP cord-348746-yaf61cmx 139 34 , , , cord-348746-yaf61cmx 139 35 and and CC cord-348746-yaf61cmx 139 36 IL-12 IL-12 NNP cord-348746-yaf61cmx 139 37 , , , cord-348746-yaf61cmx 139 38 which which WDT cord-348746-yaf61cmx 139 39 they -PRON- PRP cord-348746-yaf61cmx 139 40 attributed attribute VBD cord-348746-yaf61cmx 139 41 to to IN cord-348746-yaf61cmx 139 42 general general JJ cord-348746-yaf61cmx 139 43 immunosuppression immunosuppression NN cord-348746-yaf61cmx 139 44 . . . cord-348746-yaf61cmx 140 1 Mildly mildly RB cord-348746-yaf61cmx 140 2 increased increase VBN cord-348746-yaf61cmx 140 3 amounts amount NNS cord-348746-yaf61cmx 140 4 of of IN cord-348746-yaf61cmx 140 5 IL-1 IL-1 NNP cord-348746-yaf61cmx 140 6 ␣ ␣ NNP cord-348746-yaf61cmx 140 7 mRNA mrna NN cord-348746-yaf61cmx 140 8 are be VBP cord-348746-yaf61cmx 140 9 detected detect VBN cord-348746-yaf61cmx 140 10 inconsistently inconsistently RB cord-348746-yaf61cmx 140 11 in in IN cord-348746-yaf61cmx 140 12 association association NN cord-348746-yaf61cmx 140 13 with with IN cord-348746-yaf61cmx 140 14 lesions lesion NNS cord-348746-yaf61cmx 140 15 in in IN cord-348746-yaf61cmx 140 16 cells cell NNS cord-348746-yaf61cmx 140 17 of of IN cord-348746-yaf61cmx 140 18 many many JJ cord-348746-yaf61cmx 140 19 organs organ NNS cord-348746-yaf61cmx 140 20 in in IN cord-348746-yaf61cmx 140 21 cats cat NNS cord-348746-yaf61cmx 140 22 with with IN cord-348746-yaf61cmx 140 23 FIP FIP NNP cord-348746-yaf61cmx 140 24 . . . cord-348746-yaf61cmx 141 1 59 59 CD cord-348746-yaf61cmx 141 2 Roles role NNS cord-348746-yaf61cmx 141 3 of of IN cord-348746-yaf61cmx 141 4 IL-1 IL-1 NNP cord-348746-yaf61cmx 141 5 in in IN cord-348746-yaf61cmx 141 6 this this DT cord-348746-yaf61cmx 141 7 setting setting NN cord-348746-yaf61cmx 141 8 may may MD cord-348746-yaf61cmx 141 9 include include VB cord-348746-yaf61cmx 141 10 vascular vascular JJ cord-348746-yaf61cmx 141 11 endothelial endothelial JJ cord-348746-yaf61cmx 141 12 activation activation NN cord-348746-yaf61cmx 141 13 , , , cord-348746-yaf61cmx 141 14 regulation regulation NN cord-348746-yaf61cmx 141 15 of of IN cord-348746-yaf61cmx 141 16 macrophages macrophage NNS cord-348746-yaf61cmx 141 17 , , , cord-348746-yaf61cmx 141 18 IL-8 IL-8 NNP cord-348746-yaf61cmx 141 19 and and CC cord-348746-yaf61cmx 141 20 IL-6 IL-6 NNP cord-348746-yaf61cmx 141 21 , , , cord-348746-yaf61cmx 141 22 and and CC cord-348746-yaf61cmx 141 23 chemotaxis chemotaxis NN cord-348746-yaf61cmx 141 24 . . . cord-348746-yaf61cmx 142 1 IL-6 IL-6 NNP cord-348746-yaf61cmx 142 2 and and CC cord-348746-yaf61cmx 142 3 IL-1 IL-1 NNP cord-348746-yaf61cmx 142 4 can can MD cord-348746-yaf61cmx 142 5 increase increase VB cord-348746-yaf61cmx 142 6 B b NN cord-348746-yaf61cmx 142 7 - - HYPH cord-348746-yaf61cmx 142 8 cell cell NN cord-348746-yaf61cmx 142 9 growth growth NN cord-348746-yaf61cmx 142 10 and and CC cord-348746-yaf61cmx 142 11 differentiation differentiation NN cord-348746-yaf61cmx 142 12 and and CC cord-348746-yaf61cmx 142 13 could could MD cord-348746-yaf61cmx 142 14 exacerbate exacerbate VB cord-348746-yaf61cmx 142 15 humoral humoral JJ cord-348746-yaf61cmx 142 16 contributions contribution NNS cord-348746-yaf61cmx 142 17 to to IN cord-348746-yaf61cmx 142 18 the the DT cord-348746-yaf61cmx 142 19 severity severity NN cord-348746-yaf61cmx 142 20 of of IN cord-348746-yaf61cmx 142 21 FIP FIP NNP cord-348746-yaf61cmx 142 22 . . . cord-348746-yaf61cmx 143 1 The the DT cord-348746-yaf61cmx 143 2 inflammatory inflammatory JJ cord-348746-yaf61cmx 143 3 cytokines cytokine NNS cord-348746-yaf61cmx 143 4 TNF- tnf- RB cord-348746-yaf61cmx 144 1 ␣ ␣ NNP cord-348746-yaf61cmx 144 2 , , , cord-348746-yaf61cmx 145 1 IL-1 IL-1 NNP cord-348746-yaf61cmx 145 2 ␣ ␣ NNP cord-348746-yaf61cmx 145 3 , , , cord-348746-yaf61cmx 145 4 and and CC cord-348746-yaf61cmx 145 5 IL-6 IL-6 NNP cord-348746-yaf61cmx 145 6 could could MD cord-348746-yaf61cmx 145 7 circumvent circumvent VB cord-348746-yaf61cmx 145 8 the the DT cord-348746-yaf61cmx 145 9 blood blood NN cord-348746-yaf61cmx 145 10 - - HYPH cord-348746-yaf61cmx 145 11 brain brain NN cord-348746-yaf61cmx 145 12 barrier barrier NN cord-348746-yaf61cmx 145 13 during during IN cord-348746-yaf61cmx 145 14 systemic systemic JJ cord-348746-yaf61cmx 145 15 FIP fip NN cord-348746-yaf61cmx 145 16 , , , cord-348746-yaf61cmx 145 17 or or CC cord-348746-yaf61cmx 145 18 they -PRON- PRP cord-348746-yaf61cmx 145 19 could could MD cord-348746-yaf61cmx 145 20 cross cross VB cord-348746-yaf61cmx 145 21 the the DT cord-348746-yaf61cmx 145 22 blood blood NN cord-348746-yaf61cmx 145 23 - - HYPH cord-348746-yaf61cmx 145 24 brain brain NN cord-348746-yaf61cmx 145 25 barrier barrier NN cord-348746-yaf61cmx 145 26 after after IN cord-348746-yaf61cmx 145 27 reorganization reorganization NN cord-348746-yaf61cmx 145 28 of of IN cord-348746-yaf61cmx 145 29 the the DT cord-348746-yaf61cmx 145 30 endothelial endothelial JJ cord-348746-yaf61cmx 145 31 actin actin NN cord-348746-yaf61cmx 145 32 cytoskeleton cytoskeleton NN cord-348746-yaf61cmx 145 33 . . . cord-348746-yaf61cmx 146 1 60 60 CD cord-348746-yaf61cmx 146 2 , , , cord-348746-yaf61cmx 146 3 61 61 CD cord-348746-yaf61cmx 147 1 No no DT cord-348746-yaf61cmx 147 2 information information NN cord-348746-yaf61cmx 147 3 is be VBZ cord-348746-yaf61cmx 147 4 available available JJ cord-348746-yaf61cmx 147 5 regarding regard VBG cord-348746-yaf61cmx 147 6 cytokine cytokine NN cord-348746-yaf61cmx 147 7 production production NN cord-348746-yaf61cmx 147 8 in in IN cord-348746-yaf61cmx 147 9 neurological neurological JJ cord-348746-yaf61cmx 147 10 FIP fip NN cord-348746-yaf61cmx 147 11 , , , cord-348746-yaf61cmx 147 12 and and CC cord-348746-yaf61cmx 147 13 how how WRB cord-348746-yaf61cmx 147 14 cytokines cytokine NNS cord-348746-yaf61cmx 147 15 in in IN cord-348746-yaf61cmx 147 16 the the DT cord-348746-yaf61cmx 147 17 CNS CNS NNP cord-348746-yaf61cmx 147 18 compare compare VBP cord-348746-yaf61cmx 147 19 to to IN cord-348746-yaf61cmx 147 20 those those DT cord-348746-yaf61cmx 147 21 in in IN cord-348746-yaf61cmx 147 22 abdominal abdominal JJ cord-348746-yaf61cmx 147 23 tissues tissue NNS cord-348746-yaf61cmx 147 24 of of IN cord-348746-yaf61cmx 147 25 cats cat NNS cord-348746-yaf61cmx 147 26 with with IN cord-348746-yaf61cmx 147 27 generalized generalized JJ cord-348746-yaf61cmx 147 28 or or CC cord-348746-yaf61cmx 147 29 effusive effusive JJ cord-348746-yaf61cmx 147 30 FIP fip NN cord-348746-yaf61cmx 147 31 is be VBZ cord-348746-yaf61cmx 147 32 unknown unknown JJ cord-348746-yaf61cmx 147 33 . . . cord-348746-yaf61cmx 148 1 MHV MHV NNP cord-348746-yaf61cmx 148 2 neurological neurological JJ cord-348746-yaf61cmx 148 3 disease disease NN cord-348746-yaf61cmx 148 4 can can MD cord-348746-yaf61cmx 148 5 range range VB cord-348746-yaf61cmx 148 6 from from IN cord-348746-yaf61cmx 148 7 severe severe JJ cord-348746-yaf61cmx 148 8 , , , cord-348746-yaf61cmx 148 9 acute acute JJ cord-348746-yaf61cmx 148 10 , , , cord-348746-yaf61cmx 148 11 necrotizing necrotize VBG cord-348746-yaf61cmx 148 12 , , , cord-348746-yaf61cmx 148 13 rapidly rapidly RB cord-348746-yaf61cmx 148 14 fatal fatal JJ cord-348746-yaf61cmx 148 15 encephalitis encephalitis RB cord-348746-yaf61cmx 148 16 to to TO cord-348746-yaf61cmx 148 17 chronic chronic JJ cord-348746-yaf61cmx 148 18 immunemediated immunemediated JJ cord-348746-yaf61cmx 148 19 demyelination demyelination NN cord-348746-yaf61cmx 148 20 with with IN cord-348746-yaf61cmx 148 21 little little JJ cord-348746-yaf61cmx 148 22 encephalitis encephalitis RB cord-348746-yaf61cmx 148 23 , , , cord-348746-yaf61cmx 148 24 depending depend VBG cord-348746-yaf61cmx 148 25 on on IN cord-348746-yaf61cmx 148 26 mouse mouse NN cord-348746-yaf61cmx 148 27 strain strain NN cord-348746-yaf61cmx 148 28 , , , cord-348746-yaf61cmx 148 29 age age NN cord-348746-yaf61cmx 148 30 , , , cord-348746-yaf61cmx 148 31 and and CC cord-348746-yaf61cmx 148 32 immunocompetence immunocompetence NN cord-348746-yaf61cmx 148 33 . . . cord-348746-yaf61cmx 149 1 The the DT cord-348746-yaf61cmx 149 2 appreciation appreciation NN cord-348746-yaf61cmx 149 3 of of IN cord-348746-yaf61cmx 149 4 the the DT cord-348746-yaf61cmx 149 5 principal principal JJ cord-348746-yaf61cmx 149 6 role role NN cord-348746-yaf61cmx 149 7 of of IN cord-348746-yaf61cmx 149 8 the the DT cord-348746-yaf61cmx 149 9 immune immune JJ cord-348746-yaf61cmx 149 10 system system NN cord-348746-yaf61cmx 149 11 in in IN cord-348746-yaf61cmx 149 12 producing produce VBG cord-348746-yaf61cmx 149 13 demyelination demyelination NN cord-348746-yaf61cmx 149 14 emerged emerge VBD cord-348746-yaf61cmx 149 15 from from IN cord-348746-yaf61cmx 149 16 a a DT cord-348746-yaf61cmx 149 17 series series NN cord-348746-yaf61cmx 149 18 of of IN cord-348746-yaf61cmx 149 19 experiments experiment NNS cord-348746-yaf61cmx 149 20 performed perform VBN cord-348746-yaf61cmx 149 21 over over IN cord-348746-yaf61cmx 149 22 several several JJ cord-348746-yaf61cmx 149 23 decades decade NNS cord-348746-yaf61cmx 149 24 . . . cord-348746-yaf61cmx 150 1 Profoundly profoundly RB cord-348746-yaf61cmx 150 2 immunosuppressed immunosuppressed JJ cord-348746-yaf61cmx 150 3 mice mouse NNS cord-348746-yaf61cmx 150 4 develop develop VBP cord-348746-yaf61cmx 150 5 high high JJ cord-348746-yaf61cmx 150 6 concentrations concentration NNS cord-348746-yaf61cmx 150 7 of of IN cord-348746-yaf61cmx 150 8 virus virus NN cord-348746-yaf61cmx 150 9 in in IN cord-348746-yaf61cmx 150 10 the the DT cord-348746-yaf61cmx 150 11 CNS CNS NNP cord-348746-yaf61cmx 150 12 , , , cord-348746-yaf61cmx 150 13 but but CC cord-348746-yaf61cmx 150 14 demyelination demyelination NN cord-348746-yaf61cmx 150 15 and and CC cord-348746-yaf61cmx 150 16 clinical clinical JJ cord-348746-yaf61cmx 150 17 signs sign NNS cord-348746-yaf61cmx 150 18 are be VBP cord-348746-yaf61cmx 150 19 minimal minimal JJ cord-348746-yaf61cmx 150 20 . . . cord-348746-yaf61cmx 151 1 Immunocompetent immunocompetent NN cord-348746-yaf61cmx 151 2 mice mouse NNS cord-348746-yaf61cmx 151 3 have have VBP cord-348746-yaf61cmx 151 4 variable variable JJ cord-348746-yaf61cmx 151 5 or or CC cord-348746-yaf61cmx 151 6 even even RB cord-348746-yaf61cmx 151 7 low low JJ cord-348746-yaf61cmx 151 8 concentrations concentration NNS cord-348746-yaf61cmx 151 9 of of IN cord-348746-yaf61cmx 151 10 virus virus NN cord-348746-yaf61cmx 151 11 but but CC cord-348746-yaf61cmx 151 12 develop develop VB cord-348746-yaf61cmx 151 13 marked mark VBN cord-348746-yaf61cmx 151 14 disease disease NN cord-348746-yaf61cmx 151 15 . . . cord-348746-yaf61cmx 152 1 Immune immune JJ cord-348746-yaf61cmx 152 2 reconstitution reconstitution NN cord-348746-yaf61cmx 152 3 in in IN cord-348746-yaf61cmx 152 4 immunocompromised immunocompromised JJ cord-348746-yaf61cmx 152 5 mice mice NN cord-348746-yaf61cmx 152 6 results result NNS cord-348746-yaf61cmx 152 7 in in IN cord-348746-yaf61cmx 152 8 the the DT cord-348746-yaf61cmx 152 9 development development NN cord-348746-yaf61cmx 152 10 of of IN cord-348746-yaf61cmx 152 11 severe severe JJ cord-348746-yaf61cmx 152 12 demyelinating demyelinating JJ cord-348746-yaf61cmx 152 13 disease disease NN cord-348746-yaf61cmx 152 14 . . . cord-348746-yaf61cmx 153 1 If if IN cord-348746-yaf61cmx 153 2 mice mouse NNS cord-348746-yaf61cmx 153 3 are be VBP cord-348746-yaf61cmx 153 4 pretreated pretreate VBN cord-348746-yaf61cmx 153 5 with with IN cord-348746-yaf61cmx 153 6 passive passive JJ cord-348746-yaf61cmx 153 7 infusions infusion NNS cord-348746-yaf61cmx 153 8 of of IN cord-348746-yaf61cmx 153 9 antibodies antibody NNS cord-348746-yaf61cmx 153 10 or or CC cord-348746-yaf61cmx 153 11 T t NN cord-348746-yaf61cmx 153 12 - - HYPH cord-348746-yaf61cmx 153 13 cells cell NNS cord-348746-yaf61cmx 153 14 or or CC cord-348746-yaf61cmx 153 15 if if IN cord-348746-yaf61cmx 153 16 they -PRON- PRP cord-348746-yaf61cmx 153 17 receive receive VBP cord-348746-yaf61cmx 153 18 neuroattenuated neuroattenuated JJ cord-348746-yaf61cmx 153 19 MHV MHV NNP cord-348746-yaf61cmx 153 20 strains strain NNS cord-348746-yaf61cmx 153 21 , , , cord-348746-yaf61cmx 153 22 they -PRON- PRP cord-348746-yaf61cmx 153 23 develop develop VBP cord-348746-yaf61cmx 153 24 chronic chronic JJ cord-348746-yaf61cmx 153 25 , , , cord-348746-yaf61cmx 153 26 but but CC cord-348746-yaf61cmx 153 27 not not RB cord-348746-yaf61cmx 153 28 fatal fatal JJ cord-348746-yaf61cmx 153 29 , , , cord-348746-yaf61cmx 153 30 disease disease NN cord-348746-yaf61cmx 153 31 after after IN cord-348746-yaf61cmx 153 32 MHV MHV NNP cord-348746-yaf61cmx 153 33 - - HYPH cord-348746-yaf61cmx 153 34 JHM JHM NNP cord-348746-yaf61cmx 153 35 infection infection NN cord-348746-yaf61cmx 153 36 . . . cord-348746-yaf61cmx 154 1 62 62 CD cord-348746-yaf61cmx 154 2 , , , cord-348746-yaf61cmx 154 3 63 63 CD cord-348746-yaf61cmx 155 1 Immunocompetent Immunocompetent NNP cord-348746-yaf61cmx 155 2 C57BL/6 C57BL/6 NNP cord-348746-yaf61cmx 155 3 mice mouse NNS cord-348746-yaf61cmx 155 4 clear clear JJ cord-348746-yaf61cmx 155 5 MHV MHV NNP cord-348746-yaf61cmx 155 6 - - HYPH cord-348746-yaf61cmx 155 7 JHM JHM NNP cord-348746-yaf61cmx 155 8 virus virus NN cord-348746-yaf61cmx 155 9 from from IN cord-348746-yaf61cmx 155 10 the the DT cord-348746-yaf61cmx 155 11 brain brain NN cord-348746-yaf61cmx 155 12 but but CC cord-348746-yaf61cmx 155 13 develop develop VB cord-348746-yaf61cmx 155 14 severe severe JJ cord-348746-yaf61cmx 155 15 immune immune NN cord-348746-yaf61cmx 155 16 - - HYPH cord-348746-yaf61cmx 155 17 mediated mediate VBN cord-348746-yaf61cmx 155 18 demyelination demyelination NN cord-348746-yaf61cmx 155 19 and and CC cord-348746-yaf61cmx 155 20 paralysis paralysis NN cord-348746-yaf61cmx 155 21 . . . cord-348746-yaf61cmx 156 1 22 22 CD cord-348746-yaf61cmx 157 1 In in IN cord-348746-yaf61cmx 157 2 contrast contrast NN cord-348746-yaf61cmx 157 3 , , , cord-348746-yaf61cmx 157 4 severe severe JJ cord-348746-yaf61cmx 157 5 combined combine VBN cord-348746-yaf61cmx 157 6 immunodeficient immunodeficient JJ cord-348746-yaf61cmx 157 7 ( ( -LRB- cord-348746-yaf61cmx 157 8 SCID SCID NNP cord-348746-yaf61cmx 157 9 ) ) -RRB- cord-348746-yaf61cmx 157 10 mice mouse NNS cord-348746-yaf61cmx 157 11 have have VBP cord-348746-yaf61cmx 157 12 persistent persistent JJ cord-348746-yaf61cmx 157 13 viral viral JJ cord-348746-yaf61cmx 157 14 loads load NNS cord-348746-yaf61cmx 157 15 but but CC cord-348746-yaf61cmx 157 16 no no DT cord-348746-yaf61cmx 157 17 neurologic neurologic JJ cord-348746-yaf61cmx 157 18 impairment impairment NN cord-348746-yaf61cmx 157 19 or or CC cord-348746-yaf61cmx 157 20 detectable detectable JJ cord-348746-yaf61cmx 157 21 lesions lesion NNS cord-348746-yaf61cmx 157 22 . . . cord-348746-yaf61cmx 158 1 Gamma gamma NN cord-348746-yaf61cmx 158 2 - - HYPH cord-348746-yaf61cmx 158 3 irradiated irradiate VBN cord-348746-yaf61cmx 158 4 immunocompromised immunocompromised JJ cord-348746-yaf61cmx 158 5 mice mouse NNS cord-348746-yaf61cmx 158 6 similarly similarly RB cord-348746-yaf61cmx 158 7 were be VBD cord-348746-yaf61cmx 158 8 resistant resistant JJ cord-348746-yaf61cmx 158 9 to to IN cord-348746-yaf61cmx 158 10 chronic chronic JJ cord-348746-yaf61cmx 158 11 demyelination demyelination NN cord-348746-yaf61cmx 158 12 , , , cord-348746-yaf61cmx 158 13 but but CC cord-348746-yaf61cmx 158 14 reconstitution reconstitution NN cord-348746-yaf61cmx 158 15 of of IN cord-348746-yaf61cmx 158 16 the the DT cord-348746-yaf61cmx 158 17 immune immune JJ cord-348746-yaf61cmx 158 18 system system NN cord-348746-yaf61cmx 158 19 with with IN cord-348746-yaf61cmx 158 20 adoptive adoptive JJ cord-348746-yaf61cmx 158 21 transfer transfer NN cord-348746-yaf61cmx 158 22 of of IN cord-348746-yaf61cmx 158 23 splenocytes splenocytes NNP cord-348746-yaf61cmx 158 24 restored restore VBD cord-348746-yaf61cmx 158 25 the the DT cord-348746-yaf61cmx 158 26 immune immune NN cord-348746-yaf61cmx 158 27 - - HYPH cord-348746-yaf61cmx 158 28 mediated mediate VBN cord-348746-yaf61cmx 158 29 lesions lesion NNS cord-348746-yaf61cmx 158 30 . . . cord-348746-yaf61cmx 159 1 64 64 CD cord-348746-yaf61cmx 160 1 Both both CC cord-348746-yaf61cmx 160 2 CD4ϩ CD4ϩ NNP cord-348746-yaf61cmx 160 3 and and CC cord-348746-yaf61cmx 160 4 CD8ϩ CD8ϩ NNP cord-348746-yaf61cmx 160 5 T T NNP cord-348746-yaf61cmx 160 6 - - HYPH cord-348746-yaf61cmx 160 7 cells cell NNS cord-348746-yaf61cmx 160 8 apparently apparently RB cord-348746-yaf61cmx 160 9 are be VBP cord-348746-yaf61cmx 160 10 required require VBN cord-348746-yaf61cmx 160 11 to to TO cord-348746-yaf61cmx 160 12 clear clear VB cord-348746-yaf61cmx 160 13 MHV MHV NNP cord-348746-yaf61cmx 160 14 from from IN cord-348746-yaf61cmx 160 15 the the DT cord-348746-yaf61cmx 160 16 CNS CNS NNP cord-348746-yaf61cmx 160 17 . . . cord-348746-yaf61cmx 161 1 CD8ϩ CD8ϩ NNP cord-348746-yaf61cmx 161 2 T T NNP cord-348746-yaf61cmx 161 3 - - HYPH cord-348746-yaf61cmx 161 4 cells cell NNS cord-348746-yaf61cmx 161 5 are be VBP cord-348746-yaf61cmx 161 6 the the DT cord-348746-yaf61cmx 161 7 predominant predominant JJ cord-348746-yaf61cmx 161 8 infiltrating infiltrate VBG cord-348746-yaf61cmx 161 9 leukocyte leukocyte NN cord-348746-yaf61cmx 161 10 in in IN cord-348746-yaf61cmx 161 11 Lewis Lewis NNP cord-348746-yaf61cmx 161 12 rats rat NNS cord-348746-yaf61cmx 161 13 with with IN cord-348746-yaf61cmx 161 14 MHV MHV NNP cord-348746-yaf61cmx 161 15 - - HYPH cord-348746-yaf61cmx 161 16 JHM JHM NNP cord-348746-yaf61cmx 161 17 and and CC cord-348746-yaf61cmx 161 18 paralytic paralytic JJ cord-348746-yaf61cmx 161 19 disease disease NN cord-348746-yaf61cmx 161 20 , , , cord-348746-yaf61cmx 161 21 65 65 CD cord-348746-yaf61cmx 162 1 whereas whereas IN cord-348746-yaf61cmx 162 2 infiltration infiltration NN cord-348746-yaf61cmx 162 3 in in IN cord-348746-yaf61cmx 162 4 clinically clinically RB cord-348746-yaf61cmx 162 5 normal normal JJ cord-348746-yaf61cmx 162 6 MHV MHV NNP cord-348746-yaf61cmx 162 7 - - HYPH cord-348746-yaf61cmx 162 8 JHM JHM NNP cord-348746-yaf61cmx 162 9 - - HYPH cord-348746-yaf61cmx 162 10 positive positive JJ cord-348746-yaf61cmx 162 11 brown brown JJ cord-348746-yaf61cmx 162 12 Norway Norway NNP cord-348746-yaf61cmx 162 13 rats rat NNS cord-348746-yaf61cmx 162 14 consists consist VBZ cord-348746-yaf61cmx 162 15 of of IN cord-348746-yaf61cmx 162 16 CD4ϩ CD4ϩ NNP cord-348746-yaf61cmx 162 17 cells cell NNS cord-348746-yaf61cmx 162 18 . . . cord-348746-yaf61cmx 163 1 CTLs ctl NNS cord-348746-yaf61cmx 163 2 may may MD cord-348746-yaf61cmx 163 3 kill kill VB cord-348746-yaf61cmx 163 4 some some DT cord-348746-yaf61cmx 163 5 virally virally RB cord-348746-yaf61cmx 163 6 infected infect VBN cord-348746-yaf61cmx 163 7 cells cell NNS cord-348746-yaf61cmx 163 8 and and CC cord-348746-yaf61cmx 163 9 protect protect VB cord-348746-yaf61cmx 163 10 mice mouse NNS cord-348746-yaf61cmx 163 11 from from IN cord-348746-yaf61cmx 163 12 fatal fatal JJ cord-348746-yaf61cmx 163 13 disease disease NN cord-348746-yaf61cmx 163 14 , , , cord-348746-yaf61cmx 163 15 but but CC cord-348746-yaf61cmx 163 16 they -PRON- PRP cord-348746-yaf61cmx 163 17 do do VBP cord-348746-yaf61cmx 163 18 not not RB cord-348746-yaf61cmx 163 19 completely completely RB cord-348746-yaf61cmx 163 20 eliminate eliminate VB cord-348746-yaf61cmx 163 21 virus virus NN cord-348746-yaf61cmx 163 22 . . . cord-348746-yaf61cmx 164 1 66 66 CD cord-348746-yaf61cmx 165 1 When when WRB cord-348746-yaf61cmx 165 2 CD8ϩ-depleted cd8ϩ-depleted JJ cord-348746-yaf61cmx 165 3 mice mouse NNS cord-348746-yaf61cmx 165 4 are be VBP cord-348746-yaf61cmx 165 5 reconstituted reconstitute VBN cord-348746-yaf61cmx 165 6 , , , cord-348746-yaf61cmx 165 7 virus virus NN cord-348746-yaf61cmx 165 8 load load NN cord-348746-yaf61cmx 165 9 is be VBZ cord-348746-yaf61cmx 165 10 reduced reduce VBN cord-348746-yaf61cmx 165 11 , , , cord-348746-yaf61cmx 165 12 and and CC cord-348746-yaf61cmx 165 13 infection infection NN cord-348746-yaf61cmx 165 14 is be VBZ cord-348746-yaf61cmx 165 15 not not RB cord-348746-yaf61cmx 165 16 detected detect VBN cord-348746-yaf61cmx 165 17 in in IN cord-348746-yaf61cmx 165 18 most most RBS cord-348746-yaf61cmx 165 19 infected infected JJ cord-348746-yaf61cmx 165 20 cell cell NN cord-348746-yaf61cmx 165 21 types type NNS cord-348746-yaf61cmx 165 22 , , , cord-348746-yaf61cmx 165 23 except except IN cord-348746-yaf61cmx 165 24 for for IN cord-348746-yaf61cmx 165 25 oligodendroglial oligodendroglial JJ cord-348746-yaf61cmx 165 26 cells cell NNS cord-348746-yaf61cmx 165 27 . . . cord-348746-yaf61cmx 166 1 66 66 CD cord-348746-yaf61cmx 166 2 Mice mouse NNS cord-348746-yaf61cmx 166 3 with with IN cord-348746-yaf61cmx 166 4 nucleocapsid nucleocapsid NN cord-348746-yaf61cmx 166 5 or or CC cord-348746-yaf61cmx 166 6 spike spike NN cord-348746-yaf61cmx 166 7 proteinspecific proteinspecific JJ cord-348746-yaf61cmx 166 8 CD8ϩ CD8ϩ NNP cord-348746-yaf61cmx 166 9 T T NNP cord-348746-yaf61cmx 166 10 - - HYPH cord-348746-yaf61cmx 166 11 cells cell NNS cord-348746-yaf61cmx 166 12 develop develop VBP cord-348746-yaf61cmx 166 13 chronic chronic JJ cord-348746-yaf61cmx 166 14 demyelinating demyelinating NN cord-348746-yaf61cmx 166 15 disease disease NN cord-348746-yaf61cmx 166 16 . . . cord-348746-yaf61cmx 167 1 21 21 CD cord-348746-yaf61cmx 167 2 , , , cord-348746-yaf61cmx 167 3 67 67 CD cord-348746-yaf61cmx 168 1 In in IN cord-348746-yaf61cmx 168 2 the the DT cord-348746-yaf61cmx 168 3 MHV MHV NNP cord-348746-yaf61cmx 168 4 - - HYPH cord-348746-yaf61cmx 168 5 OBLV60 OBLV60 NNP cord-348746-yaf61cmx 168 6 model model NN cord-348746-yaf61cmx 168 7 , , , cord-348746-yaf61cmx 168 8 depletion depletion NN cord-348746-yaf61cmx 168 9 of of IN cord-348746-yaf61cmx 168 10 CD8ϩ CD8ϩ NNP cord-348746-yaf61cmx 168 11 cells cell NNS cord-348746-yaf61cmx 168 12 is be VBZ cord-348746-yaf61cmx 168 13 associated associate VBN cord-348746-yaf61cmx 168 14 with with IN cord-348746-yaf61cmx 168 15 delayed delayed JJ cord-348746-yaf61cmx 168 16 clearance clearance NN cord-348746-yaf61cmx 168 17 of of IN cord-348746-yaf61cmx 169 1 OBLV60 OBLV60 NNP cord-348746-yaf61cmx 169 2 ( ( -LRB- cord-348746-yaf61cmx 169 3 but but CC cord-348746-yaf61cmx 169 4 infected infected JJ cord-348746-yaf61cmx 169 5 mice mouse NNS cord-348746-yaf61cmx 169 6 did do VBD cord-348746-yaf61cmx 169 7 recover recover VB cord-348746-yaf61cmx 169 8 ) ) -RRB- cord-348746-yaf61cmx 169 9 . . . cord-348746-yaf61cmx 170 1 25 25 CD cord-348746-yaf61cmx 170 2 CTLs ctl NNS cord-348746-yaf61cmx 170 3 probably probably RB cord-348746-yaf61cmx 170 4 exacerbate exacerbate VBP cord-348746-yaf61cmx 170 5 lesions lesion NNS cord-348746-yaf61cmx 170 6 by by IN cord-348746-yaf61cmx 170 7 contributing contribute VBG cord-348746-yaf61cmx 170 8 to to IN cord-348746-yaf61cmx 170 9 tissue tissue NN cord-348746-yaf61cmx 170 10 damage damage NN cord-348746-yaf61cmx 170 11 . . . cord-348746-yaf61cmx 171 1 MHV MHV NNP cord-348746-yaf61cmx 171 2 is be VBZ cord-348746-yaf61cmx 171 3 relatively relatively RB cord-348746-yaf61cmx 171 4 labile labile JJ cord-348746-yaf61cmx 171 5 genetically genetically RB cord-348746-yaf61cmx 171 6 ( ( -LRB- cord-348746-yaf61cmx 171 7 a a DT cord-348746-yaf61cmx 171 8 common common JJ cord-348746-yaf61cmx 171 9 characteristic characteristic NN cord-348746-yaf61cmx 171 10 of of IN cord-348746-yaf61cmx 171 11 RNA RNA NNP cord-348746-yaf61cmx 171 12 viruses virus NNS cord-348746-yaf61cmx 171 13 ) ) -RRB- cord-348746-yaf61cmx 171 14 , , , cord-348746-yaf61cmx 171 15 and and CC cord-348746-yaf61cmx 171 16 mutant mutant JJ cord-348746-yaf61cmx 171 17 strains strain NNS cord-348746-yaf61cmx 171 18 with with IN cord-348746-yaf61cmx 171 19 recognition recognition NN cord-348746-yaf61cmx 171 20 sites site NNS cord-348746-yaf61cmx 171 21 that that WDT cord-348746-yaf61cmx 171 22 can can MD cord-348746-yaf61cmx 171 23 evade evade VB cord-348746-yaf61cmx 171 24 CTL CTL NNP cord-348746-yaf61cmx 171 25 - - HYPH cord-348746-yaf61cmx 171 26 mediated mediate VBN cord-348746-yaf61cmx 171 27 viral viral JJ cord-348746-yaf61cmx 171 28 killing killing NN cord-348746-yaf61cmx 171 29 apparently apparently RB cord-348746-yaf61cmx 171 30 increase increase VB cord-348746-yaf61cmx 171 31 and and CC cord-348746-yaf61cmx 171 32 become become VB cord-348746-yaf61cmx 171 33 the the DT cord-348746-yaf61cmx 171 34 predominant predominant JJ cord-348746-yaf61cmx 171 35 viral viral JJ cord-348746-yaf61cmx 171 36 strains strain NNS cord-348746-yaf61cmx 171 37 in in IN cord-348746-yaf61cmx 171 38 response response NN cord-348746-yaf61cmx 171 39 to to IN cord-348746-yaf61cmx 171 40 CTL CTL NNP cord-348746-yaf61cmx 171 41 - - HYPH cord-348746-yaf61cmx 171 42 mediated mediate VBN cord-348746-yaf61cmx 171 43 natural natural JJ cord-348746-yaf61cmx 171 44 selection selection NN cord-348746-yaf61cmx 171 45 . . . cord-348746-yaf61cmx 172 1 This this DT cord-348746-yaf61cmx 172 2 feature feature NN cord-348746-yaf61cmx 172 3 results result NNS cord-348746-yaf61cmx 172 4 in in IN cord-348746-yaf61cmx 172 5 disease disease NN cord-348746-yaf61cmx 172 6 progression progression NN cord-348746-yaf61cmx 172 7 in in IN cord-348746-yaf61cmx 172 8 immunocompetent immunocompetent JJ cord-348746-yaf61cmx 172 9 , , , cord-348746-yaf61cmx 172 10 but but CC cord-348746-yaf61cmx 172 11 not not RB cord-348746-yaf61cmx 172 12 immunosuppressed immunosuppressed JJ cord-348746-yaf61cmx 172 13 , , , cord-348746-yaf61cmx 172 14 hosts host NNS cord-348746-yaf61cmx 172 15 infected infect VBN cord-348746-yaf61cmx 172 16 with with IN cord-348746-yaf61cmx 172 17 these these DT cord-348746-yaf61cmx 172 18 mutants mutant NNS cord-348746-yaf61cmx 172 19 . . . cord-348746-yaf61cmx 173 1 68 68 CD cord-348746-yaf61cmx 174 1 Several several JJ cord-348746-yaf61cmx 174 2 studies study NNS cord-348746-yaf61cmx 174 3 have have VBP cord-348746-yaf61cmx 174 4 suggested suggest VBN cord-348746-yaf61cmx 174 5 that that IN cord-348746-yaf61cmx 174 6 apoptosis apoptosis NN cord-348746-yaf61cmx 174 7 may may MD cord-348746-yaf61cmx 174 8 be be VB cord-348746-yaf61cmx 174 9 important important JJ cord-348746-yaf61cmx 174 10 in in IN cord-348746-yaf61cmx 174 11 clearing clear VBG cord-348746-yaf61cmx 174 12 virus virus NN cord-348746-yaf61cmx 174 13 from from IN cord-348746-yaf61cmx 174 14 the the DT cord-348746-yaf61cmx 174 15 CNS CNS NNP cord-348746-yaf61cmx 174 16 . . . cord-348746-yaf61cmx 175 1 Specific specific JJ cord-348746-yaf61cmx 175 2 CTL CTL NNP cord-348746-yaf61cmx 175 3 recognition recognition NN cord-348746-yaf61cmx 175 4 promotes promote VBZ cord-348746-yaf61cmx 175 5 apoptosis apoptosis NN cord-348746-yaf61cmx 175 6 of of IN cord-348746-yaf61cmx 175 7 MHV mhv NN cord-348746-yaf61cmx 175 8 - - HYPH cord-348746-yaf61cmx 175 9 infected infect VBN cord-348746-yaf61cmx 175 10 cells cell NNS cord-348746-yaf61cmx 175 11 . . . cord-348746-yaf61cmx 176 1 69 69 CD cord-348746-yaf61cmx 177 1 In in IN cord-348746-yaf61cmx 177 2 experimental experimental JJ cord-348746-yaf61cmx 177 3 allergic allergic JJ cord-348746-yaf61cmx 177 4 encephalomyelitis encephalomyelitis NN cord-348746-yaf61cmx 177 5 in in IN cord-348746-yaf61cmx 177 6 rats rat NNS cord-348746-yaf61cmx 177 7 , , , cord-348746-yaf61cmx 177 8 apoptosis apoptosis NN cord-348746-yaf61cmx 177 9 appears appear VBZ cord-348746-yaf61cmx 177 10 to to TO cord-348746-yaf61cmx 177 11 help help VB cord-348746-yaf61cmx 177 12 control control VB cord-348746-yaf61cmx 177 13 inflammation inflammation NN cord-348746-yaf61cmx 177 14 . . . cord-348746-yaf61cmx 178 1 70 70 CD cord-348746-yaf61cmx 179 1 The the DT cord-348746-yaf61cmx 179 2 role role NN cord-348746-yaf61cmx 179 3 of of IN cord-348746-yaf61cmx 179 4 CD4ϩ CD4ϩ NNP cord-348746-yaf61cmx 179 5 cells cell NNS cord-348746-yaf61cmx 179 6 in in IN cord-348746-yaf61cmx 179 7 MHV MHV NNP cord-348746-yaf61cmx 179 8 infection infection NN cord-348746-yaf61cmx 179 9 is be VBZ cord-348746-yaf61cmx 179 10 also also RB cord-348746-yaf61cmx 179 11 complex complex JJ cord-348746-yaf61cmx 179 12 . . . cord-348746-yaf61cmx 180 1 Nucleocapsid nucleocapsid JJ cord-348746-yaf61cmx 180 2 or or CC cord-348746-yaf61cmx 180 3 spike spike NN cord-348746-yaf61cmx 180 4 protein protein NN cord-348746-yaf61cmx 180 5 - - HYPH cord-348746-yaf61cmx 180 6 specific specific JJ cord-348746-yaf61cmx 180 7 CD4ϩ CD4ϩ NNP cord-348746-yaf61cmx 180 8 T T NNP cord-348746-yaf61cmx 180 9 - - HYPH cord-348746-yaf61cmx 180 10 cells cell NNS cord-348746-yaf61cmx 180 11 have have VBP cord-348746-yaf61cmx 180 12 been be VBN cord-348746-yaf61cmx 180 13 shown show VBN cord-348746-yaf61cmx 180 14 to to TO cord-348746-yaf61cmx 180 15 protect protect VB cord-348746-yaf61cmx 180 16 mice mouse NNS cord-348746-yaf61cmx 180 17 from from IN cord-348746-yaf61cmx 180 18 coronaviral coronaviral JJ cord-348746-yaf61cmx 180 19 encephalomyelitis encephalomyelitis NN cord-348746-yaf61cmx 180 20 in in IN cord-348746-yaf61cmx 180 21 the the DT cord-348746-yaf61cmx 180 22 absence absence NN cord-348746-yaf61cmx 180 23 of of IN cord-348746-yaf61cmx 180 24 CD8ϩ CD8ϩ NNP cord-348746-yaf61cmx 180 25 T T NNP cord-348746-yaf61cmx 180 26 - - HYPH cord-348746-yaf61cmx 180 27 cells cell NNS cord-348746-yaf61cmx 180 28 . . . cord-348746-yaf61cmx 181 1 71 71 CD cord-348746-yaf61cmx 182 1 If if IN cord-348746-yaf61cmx 182 2 mice mouse NNS cord-348746-yaf61cmx 182 3 with with IN cord-348746-yaf61cmx 182 4 MHV MHV NNP cord-348746-yaf61cmx 182 5 - - HYPH cord-348746-yaf61cmx 182 6 OBLV60 OBLV60 NNP cord-348746-yaf61cmx 182 7 had have VBD cord-348746-yaf61cmx 182 8 CD8ϩ CD8ϩ NNP cord-348746-yaf61cmx 182 9 but but CC cord-348746-yaf61cmx 182 10 not not RB cord-348746-yaf61cmx 182 11 CD4ϩ cd4ϩ NN cord-348746-yaf61cmx 182 12 cells cell NNS cord-348746-yaf61cmx 182 13 , , , cord-348746-yaf61cmx 182 14 they -PRON- PRP cord-348746-yaf61cmx 182 15 developed develop VBD cord-348746-yaf61cmx 182 16 persistent persistent JJ cord-348746-yaf61cmx 182 17 infection infection NN cord-348746-yaf61cmx 182 18 . . . cord-348746-yaf61cmx 183 1 If if IN cord-348746-yaf61cmx 183 2 they -PRON- PRP cord-348746-yaf61cmx 183 3 were be VBD cord-348746-yaf61cmx 183 4 CD8ϩ CD8ϩ NNP cord-348746-yaf61cmx 183 5 deficient deficient JJ cord-348746-yaf61cmx 183 6 , , , cord-348746-yaf61cmx 183 7 but but CC cord-348746-yaf61cmx 183 8 CD4ϩ cd4ϩ NN cord-348746-yaf61cmx 183 9 cells cell NNS cord-348746-yaf61cmx 183 10 were be VBD cord-348746-yaf61cmx 183 11 normal normal JJ cord-348746-yaf61cmx 183 12 , , , cord-348746-yaf61cmx 183 13 they -PRON- PRP cord-348746-yaf61cmx 183 14 had have VBD cord-348746-yaf61cmx 183 15 delayed delay VBN cord-348746-yaf61cmx 183 16 clearance clearance NN cord-348746-yaf61cmx 183 17 of of IN cord-348746-yaf61cmx 183 18 the the DT cord-348746-yaf61cmx 183 19 virus virus NN cord-348746-yaf61cmx 183 20 , , , cord-348746-yaf61cmx 183 21 suggesting suggest VBG cord-348746-yaf61cmx 183 22 a a DT cord-348746-yaf61cmx 183 23 primary primary JJ cord-348746-yaf61cmx 183 24 role role NN cord-348746-yaf61cmx 183 25 for for IN cord-348746-yaf61cmx 183 26 CD4ϩ CD4ϩ NNP cord-348746-yaf61cmx 183 27 cells cell NNS cord-348746-yaf61cmx 183 28 in in IN cord-348746-yaf61cmx 183 29 clearing clear VBG cord-348746-yaf61cmx 183 30 this this DT cord-348746-yaf61cmx 183 31 virus virus NN cord-348746-yaf61cmx 183 32 . . . cord-348746-yaf61cmx 184 1 25 25 CD cord-348746-yaf61cmx 185 1 Sussman Sussman NNP cord-348746-yaf61cmx 185 2 et et NNP cord-348746-yaf61cmx 185 3 al al NNP cord-348746-yaf61cmx 185 4 72 72 CD cord-348746-yaf61cmx 185 5 and and CC cord-348746-yaf61cmx 185 6 Williamson Williamson NNP cord-348746-yaf61cmx 185 7 and and CC cord-348746-yaf61cmx 185 8 Stohlman Stohlman NNP cord-348746-yaf61cmx 185 9 73 73 CD cord-348746-yaf61cmx 185 10 documented document VBD cord-348746-yaf61cmx 185 11 the the DT cord-348746-yaf61cmx 185 12 requirement requirement NN cord-348746-yaf61cmx 185 13 for for IN cord-348746-yaf61cmx 185 14 CD4ϩ CD4ϩ NNP cord-348746-yaf61cmx 185 15 cells cell NNS cord-348746-yaf61cmx 185 16 for for IN cord-348746-yaf61cmx 185 17 clearance clearance NN cord-348746-yaf61cmx 185 18 of of IN cord-348746-yaf61cmx 185 19 JHM JHM NNP cord-348746-yaf61cmx 185 20 from from IN cord-348746-yaf61cmx 185 21 mice mouse NNS cord-348746-yaf61cmx 185 22 . . . cord-348746-yaf61cmx 186 1 However however RB cord-348746-yaf61cmx 186 2 , , , cord-348746-yaf61cmx 186 3 ␥ ␥ NNP cord-348746-yaf61cmx 186 4 -irradiated -irradiated JJ cord-348746-yaf61cmx 186 5 mice mouse NNS cord-348746-yaf61cmx 186 6 that that WDT cord-348746-yaf61cmx 186 7 were be VBD cord-348746-yaf61cmx 186 8 reconstituted reconstitute VBN cord-348746-yaf61cmx 186 9 with with IN cord-348746-yaf61cmx 186 10 CD4ϩ CD4ϩ NNP cord-348746-yaf61cmx 186 11 cells cell NNS cord-348746-yaf61cmx 186 12 responded respond VBD cord-348746-yaf61cmx 186 13 to to IN cord-348746-yaf61cmx 186 14 MHV MHV NNP cord-348746-yaf61cmx 186 15 - - HYPH cord-348746-yaf61cmx 186 16 JHM JHM NNP cord-348746-yaf61cmx 186 17 challenge challenge NN cord-348746-yaf61cmx 186 18 with with IN cord-348746-yaf61cmx 186 19 earlier early JJR cord-348746-yaf61cmx 186 20 and and CC cord-348746-yaf61cmx 186 21 more more RBR cord-348746-yaf61cmx 186 22 severe severe JJ cord-348746-yaf61cmx 186 23 onset onset NN cord-348746-yaf61cmx 186 24 of of IN cord-348746-yaf61cmx 186 25 neurological neurological JJ cord-348746-yaf61cmx 186 26 disease disease NN cord-348746-yaf61cmx 186 27 . . . cord-348746-yaf61cmx 187 1 74 74 CD cord-348746-yaf61cmx 187 2 CD4ϩ cd4ϩ NN cord-348746-yaf61cmx 187 3 knockout knockout NN cord-348746-yaf61cmx 187 4 mice mouse NNS cord-348746-yaf61cmx 187 5 had have VBD cord-348746-yaf61cmx 187 6 less less JJR cord-348746-yaf61cmx 187 7 inflammation inflammation NN cord-348746-yaf61cmx 187 8 ( ( -LRB- cord-348746-yaf61cmx 187 9 with with IN cord-348746-yaf61cmx 187 10 fewer few JJR cord-348746-yaf61cmx 187 11 macrophages macrophage NNS cord-348746-yaf61cmx 187 12 and and CC cord-348746-yaf61cmx 187 13 microglial microglial JJ cord-348746-yaf61cmx 187 14 cells cell NNS cord-348746-yaf61cmx 187 15 ) ) -RRB- cord-348746-yaf61cmx 187 16 and and CC cord-348746-yaf61cmx 187 17 less less JJR cord-348746-yaf61cmx 187 18 demyelination demyelination NN cord-348746-yaf61cmx 187 19 than than IN cord-348746-yaf61cmx 187 20 did do VBD cord-348746-yaf61cmx 187 21 CD4ϩ CD4ϩ NNP cord-348746-yaf61cmx 187 22 competent competent JJ cord-348746-yaf61cmx 187 23 mice mouse NNS cord-348746-yaf61cmx 187 24 . . . cord-348746-yaf61cmx 188 1 75 75 CD cord-348746-yaf61cmx 189 1 The the DT cord-348746-yaf61cmx 189 2 presence presence NN cord-348746-yaf61cmx 189 3 of of IN cord-348746-yaf61cmx 189 4 MHV MHV NNP cord-348746-yaf61cmx 189 5 - - HYPH cord-348746-yaf61cmx 189 6 JHM JHM NNP cord-348746-yaf61cmx 189 7 in in IN cord-348746-yaf61cmx 189 8 astrocytes astrocyte NNS cord-348746-yaf61cmx 189 9 triggers trigger VBZ cord-348746-yaf61cmx 189 10 a a DT cord-348746-yaf61cmx 189 11 cytokine cytokine NN cord-348746-yaf61cmx 189 12 cascade cascade NN cord-348746-yaf61cmx 189 13 that that WDT cord-348746-yaf61cmx 189 14 contributes contribute VBZ cord-348746-yaf61cmx 189 15 to to IN cord-348746-yaf61cmx 189 16 demyelination demyelination NN cord-348746-yaf61cmx 189 17 . . . cord-348746-yaf61cmx 190 1 76 76 CD cord-348746-yaf61cmx 191 1 Sun Sun NNP cord-348746-yaf61cmx 191 2 et et NNP cord-348746-yaf61cmx 191 3 al al NNP cord-348746-yaf61cmx 191 4 77 77 CD cord-348746-yaf61cmx 191 5 documented document VBD cord-348746-yaf61cmx 191 6 production production NN cord-348746-yaf61cmx 191 7 of of IN cord-348746-yaf61cmx 191 8 TNF- TNF- NNP cord-348746-yaf61cmx 191 9 ␣ ␣ NN cord-348746-yaf61cmx 191 10 , , , cord-348746-yaf61cmx 191 11 IL-1 IL-1 NNP cord-348746-yaf61cmx 191 12 ␤ ␤ NNP cord-348746-yaf61cmx 191 13 , , , cord-348746-yaf61cmx 191 14 and and CC cord-348746-yaf61cmx 191 15 IL-6 IL-6 NNP cord-348746-yaf61cmx 191 16 by by IN cord-348746-yaf61cmx 191 17 astrocytes astrocyte NNS cord-348746-yaf61cmx 191 18 in in IN cord-348746-yaf61cmx 191 19 the the DT cord-348746-yaf61cmx 191 20 spinal spinal JJ cord-348746-yaf61cmx 191 21 cords cord NNS cord-348746-yaf61cmx 191 22 of of IN cord-348746-yaf61cmx 191 23 mice mouse NNS cord-348746-yaf61cmx 191 24 that that WDT cord-348746-yaf61cmx 191 25 were be VBD cord-348746-yaf61cmx 191 26 chronically chronically RB cord-348746-yaf61cmx 191 27 infected infect VBN cord-348746-yaf61cmx 191 28 with with IN cord-348746-yaf61cmx 191 29 MHV MHV NNP cord-348746-yaf61cmx 191 30 - - HYPH cord-348746-yaf61cmx 191 31 JHM JHM NNP cord-348746-yaf61cmx 191 32 , , , cord-348746-yaf61cmx 191 33 localized localize VBN cord-348746-yaf61cmx 191 34 to to IN cord-348746-yaf61cmx 191 35 areas area NNS cord-348746-yaf61cmx 191 36 of of IN cord-348746-yaf61cmx 191 37 virus virus NN cord-348746-yaf61cmx 191 38 infection infection NN cord-348746-yaf61cmx 191 39 and and CC cord-348746-yaf61cmx 191 40 demyelination demyelination NN cord-348746-yaf61cmx 191 41 . . . cord-348746-yaf61cmx 192 1 TNF- TNF- NNP cord-348746-yaf61cmx 193 1 ␣ ␣ NNP cord-348746-yaf61cmx 193 2 and and CC cord-348746-yaf61cmx 193 3 IL-6 IL-6 NNP cord-348746-yaf61cmx 193 4 are be VBP cord-348746-yaf61cmx 193 5 also also RB cord-348746-yaf61cmx 193 6 produced produce VBN cord-348746-yaf61cmx 193 7 in in IN cord-348746-yaf61cmx 193 8 the the DT cord-348746-yaf61cmx 193 9 brains brain NNS cord-348746-yaf61cmx 193 10 of of IN cord-348746-yaf61cmx 193 11 acutely acutely RB cord-348746-yaf61cmx 193 12 infected infected JJ cord-348746-yaf61cmx 193 13 mice mouse NNS cord-348746-yaf61cmx 193 14 , , , cord-348746-yaf61cmx 193 15 but but CC cord-348746-yaf61cmx 193 16 the the DT cord-348746-yaf61cmx 193 17 major major JJ cord-348746-yaf61cmx 193 18 cell cell NN cord-348746-yaf61cmx 193 19 producing produce VBG cord-348746-yaf61cmx 193 20 these these DT cord-348746-yaf61cmx 193 21 cytokines cytokine NNS cord-348746-yaf61cmx 193 22 is be VBZ cord-348746-yaf61cmx 193 23 the the DT cord-348746-yaf61cmx 193 24 macrophage macrophage NN cord-348746-yaf61cmx 193 25 . . . cord-348746-yaf61cmx 194 1 These these DT cord-348746-yaf61cmx 194 2 cytokines cytokine NNS cord-348746-yaf61cmx 194 3 may may MD cord-348746-yaf61cmx 194 4 help help VB cord-348746-yaf61cmx 194 5 recruit recruit VB cord-348746-yaf61cmx 194 6 T T NNP cord-348746-yaf61cmx 194 7 - - HYPH cord-348746-yaf61cmx 194 8 cells cell NNS cord-348746-yaf61cmx 194 9 and and CC cord-348746-yaf61cmx 194 10 monocytes monocyte NNS cord-348746-yaf61cmx 194 11 and and CC cord-348746-yaf61cmx 194 12 may may MD cord-348746-yaf61cmx 194 13 increase increase VB cord-348746-yaf61cmx 194 14 vascular vascular JJ cord-348746-yaf61cmx 194 15 permeability permeability NN cord-348746-yaf61cmx 194 16 . . . cord-348746-yaf61cmx 195 1 78 78 CD cord-348746-yaf61cmx 195 2 IL-1 IL-1 NNP cord-348746-yaf61cmx 195 3 ␤ ␤ NNP cord-348746-yaf61cmx 195 4 promotes promote VBZ cord-348746-yaf61cmx 195 5 leukocyte leukocyte NN cord-348746-yaf61cmx 195 6 adhesion adhesion NN cord-348746-yaf61cmx 195 7 to to IN cord-348746-yaf61cmx 195 8 endothelial endothelial JJ cord-348746-yaf61cmx 195 9 cells cell NNS cord-348746-yaf61cmx 195 10 , , , cord-348746-yaf61cmx 195 11 and and CC cord-348746-yaf61cmx 196 1 TNF- TNF- NNP cord-348746-yaf61cmx 196 2 ␣ ␣ NN cord-348746-yaf61cmx 196 3 is be VBZ cord-348746-yaf61cmx 196 4 toxic toxic JJ cord-348746-yaf61cmx 196 5 to to IN cord-348746-yaf61cmx 196 6 oligodendrocytes oligodendrocyte NNS cord-348746-yaf61cmx 196 7 . . . cord-348746-yaf61cmx 197 1 63 63 CD cord-348746-yaf61cmx 198 1 The the DT cord-348746-yaf61cmx 198 2 role role NN cord-348746-yaf61cmx 198 3 of of IN cord-348746-yaf61cmx 198 4 IL-6 IL-6 NNP cord-348746-yaf61cmx 198 5 is be VBZ cord-348746-yaf61cmx 198 6 unclear unclear JJ cord-348746-yaf61cmx 198 7 . . . cord-348746-yaf61cmx 199 1 Effects effect NNS cord-348746-yaf61cmx 199 2 attributed attribute VBN cord-348746-yaf61cmx 199 3 to to IN cord-348746-yaf61cmx 199 4 IL-6 IL-6 NNP cord-348746-yaf61cmx 199 5 include include VB cord-348746-yaf61cmx 199 6 recruitment recruitment NN cord-348746-yaf61cmx 199 7 and and CC cord-348746-yaf61cmx 199 8 activation activation NN cord-348746-yaf61cmx 199 9 of of IN cord-348746-yaf61cmx 199 10 T t NN cord-348746-yaf61cmx 199 11 - - HYPH cord-348746-yaf61cmx 199 12 cells cell NNS cord-348746-yaf61cmx 199 13 and and CC cord-348746-yaf61cmx 199 14 macrophages macrophage NNS cord-348746-yaf61cmx 199 15 , , , cord-348746-yaf61cmx 199 16 expansion expansion NN cord-348746-yaf61cmx 199 17 of of IN cord-348746-yaf61cmx 199 18 CTLs CTLs NNP cord-348746-yaf61cmx 199 19 , , , cord-348746-yaf61cmx 199 20 modulation modulation NN cord-348746-yaf61cmx 199 21 of of IN cord-348746-yaf61cmx 199 22 plasma plasma NN cord-348746-yaf61cmx 199 23 cell cell NN cord-348746-yaf61cmx 199 24 differentiation differentiation NN cord-348746-yaf61cmx 199 25 , , , cord-348746-yaf61cmx 199 26 increased increase VBN cord-348746-yaf61cmx 199 27 vascular vascular JJ cord-348746-yaf61cmx 199 28 permeability permeability NN cord-348746-yaf61cmx 199 29 , , , cord-348746-yaf61cmx 199 30 downregulation downregulation NN cord-348746-yaf61cmx 199 31 of of IN cord-348746-yaf61cmx 199 32 acute acute JJ cord-348746-yaf61cmx 199 33 phase phase NN cord-348746-yaf61cmx 199 34 proteins protein NNS cord-348746-yaf61cmx 199 35 , , , cord-348746-yaf61cmx 199 36 and and CC cord-348746-yaf61cmx 199 37 contributions contribution NNS cord-348746-yaf61cmx 199 38 to to IN cord-348746-yaf61cmx 199 39 immune immune NN cord-348746-yaf61cmx 199 40 - - HYPH cord-348746-yaf61cmx 199 41 mediated mediate VBN cord-348746-yaf61cmx 199 42 destruction destruction NN cord-348746-yaf61cmx 199 43 in in IN cord-348746-yaf61cmx 199 44 the the DT cord-348746-yaf61cmx 199 45 CNS CNS NNP cord-348746-yaf61cmx 199 46 . . . cord-348746-yaf61cmx 200 1 [ [ -LRB- cord-348746-yaf61cmx 200 2 79 79 CD cord-348746-yaf61cmx 200 3 ] ] -RRB- cord-348746-yaf61cmx 200 4 [ [ -LRB- cord-348746-yaf61cmx 200 5 80 80 CD cord-348746-yaf61cmx 200 6 ] ] -RRB- cord-348746-yaf61cmx 201 1 [ [ -LRB- cord-348746-yaf61cmx 201 2 81 81 CD cord-348746-yaf61cmx 201 3 ] ] -RRB- cord-348746-yaf61cmx 201 4 [ [ -LRB- cord-348746-yaf61cmx 201 5 82 82 CD cord-348746-yaf61cmx 201 6 ] ] -RRB- cord-348746-yaf61cmx 202 1 In in IN cord-348746-yaf61cmx 202 2 a a DT cord-348746-yaf61cmx 202 3 study study NN cord-348746-yaf61cmx 202 4 of of IN cord-348746-yaf61cmx 202 5 cytokine cytokine NN cord-348746-yaf61cmx 202 6 profiles profile NNS cord-348746-yaf61cmx 202 7 in in IN cord-348746-yaf61cmx 202 8 lethally lethally RB cord-348746-yaf61cmx 202 9 compared compare VBN cord-348746-yaf61cmx 202 10 to to IN cord-348746-yaf61cmx 202 11 sublethally sublethally RB cord-348746-yaf61cmx 202 12 affected affected JJ cord-348746-yaf61cmx 202 13 mice mouse NNS cord-348746-yaf61cmx 202 14 with with IN cord-348746-yaf61cmx 202 15 JHM JHM NNP cord-348746-yaf61cmx 202 16 , , , cord-348746-yaf61cmx 202 17 both both CC cord-348746-yaf61cmx 202 18 TH TH NNP cord-348746-yaf61cmx 202 19 1 1 CD cord-348746-yaf61cmx 203 1 -and -and : cord-348746-yaf61cmx 203 2 TH th XX cord-348746-yaf61cmx 204 1 2type 2type LS cord-348746-yaf61cmx 204 2 cytokines cytokine NNS cord-348746-yaf61cmx 204 3 , , , cord-348746-yaf61cmx 204 4 including include VBG cord-348746-yaf61cmx 204 5 IFN- IFN- NNP cord-348746-yaf61cmx 204 6 ␥ ␥ NNP cord-348746-yaf61cmx 204 7 , , , cord-348746-yaf61cmx 204 8 IL-4 IL-4 NNP cord-348746-yaf61cmx 204 9 , , , cord-348746-yaf61cmx 204 10 and and CC cord-348746-yaf61cmx 204 11 IL-10 IL-10 NNP cord-348746-yaf61cmx 204 12 , , , cord-348746-yaf61cmx 204 13 were be VBD cord-348746-yaf61cmx 204 14 induced induce VBN cord-348746-yaf61cmx 204 15 in in IN cord-348746-yaf61cmx 204 16 all all DT cord-348746-yaf61cmx 204 17 mice mouse NNS cord-348746-yaf61cmx 204 18 . . . cord-348746-yaf61cmx 205 1 83 83 CD cord-348746-yaf61cmx 206 1 In in IN cord-348746-yaf61cmx 206 2 the the DT cord-348746-yaf61cmx 206 3 mice mice NN cord-348746-yaf61cmx 206 4 that that WDT cord-348746-yaf61cmx 206 5 died die VBD cord-348746-yaf61cmx 206 6 , , , cord-348746-yaf61cmx 206 7 TNF- TNF- NNP cord-348746-yaf61cmx 206 8 ␣ ␣ NNP cord-348746-yaf61cmx 206 9 was be VBD cord-348746-yaf61cmx 206 10 induced induce VBN cord-348746-yaf61cmx 206 11 more more RBR cord-348746-yaf61cmx 206 12 rapidly rapidly RB cord-348746-yaf61cmx 206 13 , , , cord-348746-yaf61cmx 206 14 and and CC cord-348746-yaf61cmx 207 1 IL-1 IL-1 NNP cord-348746-yaf61cmx 207 2 ␣ ␣ NNP cord-348746-yaf61cmx 207 3 was be VBD cord-348746-yaf61cmx 207 4 increased increase VBN cord-348746-yaf61cmx 207 5 . . . cord-348746-yaf61cmx 208 1 In in IN cord-348746-yaf61cmx 208 2 mice mouse NNS cord-348746-yaf61cmx 208 3 with with IN cord-348746-yaf61cmx 208 4 nonlethal nonlethal JJ cord-348746-yaf61cmx 208 5 infections infection NNS cord-348746-yaf61cmx 208 6 , , , cord-348746-yaf61cmx 208 7 IL-12 IL-12 NNP cord-348746-yaf61cmx 208 8 and and CC cord-348746-yaf61cmx 208 9 IL-1 IL-1 NNP cord-348746-yaf61cmx 208 10 ␤ ␤ NNP cord-348746-yaf61cmx 208 11 were be VBD cord-348746-yaf61cmx 208 12 increased increase VBN cord-348746-yaf61cmx 208 13 , , , cord-348746-yaf61cmx 208 14 and and CC cord-348746-yaf61cmx 208 15 IL-6 IL-6 NNP cord-348746-yaf61cmx 208 16 was be VBD cord-348746-yaf61cmx 208 17 expressed express VBN cord-348746-yaf61cmx 208 18 early early RB cord-348746-yaf61cmx 208 19 . . . cord-348746-yaf61cmx 209 1 Minor minor JJ cord-348746-yaf61cmx 209 2 differences difference NNS cord-348746-yaf61cmx 209 3 were be VBD cord-348746-yaf61cmx 209 4 observed observe VBN cord-348746-yaf61cmx 209 5 in in IN cord-348746-yaf61cmx 209 6 the the DT cord-348746-yaf61cmx 209 7 patterns pattern NNS cord-348746-yaf61cmx 209 8 of of IN cord-348746-yaf61cmx 209 9 inflammation inflammation NN cord-348746-yaf61cmx 209 10 in in IN cord-348746-yaf61cmx 209 11 IL-10-deficient IL-10-deficient NNP cord-348746-yaf61cmx 209 12 compared compare VBN cord-348746-yaf61cmx 209 13 to to IN cord-348746-yaf61cmx 209 14 syngeneic syngeneic NNS cord-348746-yaf61cmx 209 15 mice mouse NNS cord-348746-yaf61cmx 209 16 , , , cord-348746-yaf61cmx 209 17 but but CC cord-348746-yaf61cmx 209 18 the the DT cord-348746-yaf61cmx 209 19 outcome outcome NN cord-348746-yaf61cmx 209 20 of of IN cord-348746-yaf61cmx 209 21 infection infection NN cord-348746-yaf61cmx 209 22 ( ( -LRB- cord-348746-yaf61cmx 209 23 eg eg UH cord-348746-yaf61cmx 209 24 , , , cord-348746-yaf61cmx 209 25 mortality mortality NN cord-348746-yaf61cmx 209 26 and and CC cord-348746-yaf61cmx 209 27 virus virus NN cord-348746-yaf61cmx 209 28 load load NN cord-348746-yaf61cmx 209 29 ) ) -RRB- cord-348746-yaf61cmx 209 30 was be VBD cord-348746-yaf61cmx 209 31 not not RB cord-348746-yaf61cmx 209 32 affected affect VBN cord-348746-yaf61cmx 209 33 . . . cord-348746-yaf61cmx 210 1 84 84 CD cord-348746-yaf61cmx 211 1 These these DT cord-348746-yaf61cmx 211 2 results result NNS cord-348746-yaf61cmx 211 3 , , , cord-348746-yaf61cmx 211 4 combined combine VBN cord-348746-yaf61cmx 211 5 with with IN cord-348746-yaf61cmx 211 6 those those DT cord-348746-yaf61cmx 211 7 of of IN cord-348746-yaf61cmx 211 8 Sun Sun NNP cord-348746-yaf61cmx 211 9 et et NNP cord-348746-yaf61cmx 211 10 al al NNP cord-348746-yaf61cmx 211 11 , , , cord-348746-yaf61cmx 211 12 77 77 CD cord-348746-yaf61cmx 211 13 suggest suggest VBP cord-348746-yaf61cmx 211 14 that that IN cord-348746-yaf61cmx 211 15 IL-1 IL-1 NNP cord-348746-yaf61cmx 211 16 ␤ ␤ NNP cord-348746-yaf61cmx 211 17 may may MD cord-348746-yaf61cmx 211 18 allow allow VB cord-348746-yaf61cmx 211 19 mice mouse NNS cord-348746-yaf61cmx 211 20 to to TO cord-348746-yaf61cmx 211 21 survive survive VB cord-348746-yaf61cmx 211 22 the the DT cord-348746-yaf61cmx 211 23 early early JJ cord-348746-yaf61cmx 211 24 stages stage NNS cord-348746-yaf61cmx 211 25 of of IN cord-348746-yaf61cmx 211 26 the the DT cord-348746-yaf61cmx 211 27 disease disease NN cord-348746-yaf61cmx 211 28 but but CC cord-348746-yaf61cmx 211 29 may may MD cord-348746-yaf61cmx 211 30 not not RB cord-348746-yaf61cmx 211 31 allow allow VB cord-348746-yaf61cmx 211 32 for for IN cord-348746-yaf61cmx 211 33 clearance clearance NN cord-348746-yaf61cmx 211 34 of of IN cord-348746-yaf61cmx 211 35 chronic chronic JJ cord-348746-yaf61cmx 211 36 infection infection NN cord-348746-yaf61cmx 211 37 . . . cord-348746-yaf61cmx 212 1 Interferon- Interferon- NNP cord-348746-yaf61cmx 212 2 ␥ ␥ NNP cord-348746-yaf61cmx 212 3 also also RB cord-348746-yaf61cmx 212 4 appears appear VBZ cord-348746-yaf61cmx 212 5 to to TO cord-348746-yaf61cmx 212 6 be be VB cord-348746-yaf61cmx 212 7 important important JJ cord-348746-yaf61cmx 212 8 for for IN cord-348746-yaf61cmx 212 9 clearance clearance NN cord-348746-yaf61cmx 212 10 of of IN cord-348746-yaf61cmx 212 11 MHV MHV NNP cord-348746-yaf61cmx 212 12 infection infection NN cord-348746-yaf61cmx 212 13 . . . cord-348746-yaf61cmx 213 1 IFN- IFN- NNP cord-348746-yaf61cmx 213 2 ␥ ␥ NNP cord-348746-yaf61cmx 213 3 -deficient -deficient JJR cord-348746-yaf61cmx 213 4 mice mouse NNS cord-348746-yaf61cmx 213 5 developed develop VBD cord-348746-yaf61cmx 213 6 persistent persistent JJ cord-348746-yaf61cmx 213 7 JHM JHM NNP cord-348746-yaf61cmx 213 8 infection infection NN cord-348746-yaf61cmx 213 9 with with IN cord-348746-yaf61cmx 213 10 increased increase VBN cord-348746-yaf61cmx 213 11 clinical clinical JJ cord-348746-yaf61cmx 213 12 signs sign NNS cord-348746-yaf61cmx 213 13 and and CC cord-348746-yaf61cmx 213 14 mortality mortality NN cord-348746-yaf61cmx 213 15 compared compare VBN cord-348746-yaf61cmx 213 16 to to IN cord-348746-yaf61cmx 213 17 mice mouse NNS cord-348746-yaf61cmx 213 18 competent competent JJ cord-348746-yaf61cmx 213 19 to to TO cord-348746-yaf61cmx 213 20 produce produce VB cord-348746-yaf61cmx 213 21 IFN- IFN- NNP cord-348746-yaf61cmx 213 22 ␥ ␥ NNP cord-348746-yaf61cmx 213 23 . . . cord-348746-yaf61cmx 213 24 85 85 CD cord-348746-yaf61cmx 213 25 Antiviral antiviral JJ cord-348746-yaf61cmx 213 26 antibody antibody NN cord-348746-yaf61cmx 213 27 and and CC cord-348746-yaf61cmx 213 28 CTL CTL NNP cord-348746-yaf61cmx 213 29 responses response NNS cord-348746-yaf61cmx 213 30 were be VBD cord-348746-yaf61cmx 213 31 normal normal JJ cord-348746-yaf61cmx 213 32 in in IN cord-348746-yaf61cmx 213 33 IFN- IFN- NNP cord-348746-yaf61cmx 213 34 ␥ ␥ CD cord-348746-yaf61cmx 213 35 -negative -negative JJ cord-348746-yaf61cmx 213 36 mice mouse NNS cord-348746-yaf61cmx 213 37 , , , cord-348746-yaf61cmx 213 38 despite despite IN cord-348746-yaf61cmx 213 39 the the DT cord-348746-yaf61cmx 213 40 fact fact NN cord-348746-yaf61cmx 213 41 that that IN cord-348746-yaf61cmx 213 42 IFN- IFN- NNP cord-348746-yaf61cmx 213 43 ␥ ␥ NNP cord-348746-yaf61cmx 213 44 modulates modulate VBZ cord-348746-yaf61cmx 213 45 antibody antibody NN cord-348746-yaf61cmx 213 46 production production NN cord-348746-yaf61cmx 213 47 . . . cord-348746-yaf61cmx 214 1 Viral viral JJ cord-348746-yaf61cmx 214 2 antigen antigen NN cord-348746-yaf61cmx 214 3 occurred occur VBD cord-348746-yaf61cmx 214 4 in in IN cord-348746-yaf61cmx 214 5 oligodendrocytes oligodendrocyte NNS cord-348746-yaf61cmx 214 6 and and CC cord-348746-yaf61cmx 214 7 in in IN cord-348746-yaf61cmx 214 8 association association NN cord-348746-yaf61cmx 214 9 with with IN cord-348746-yaf61cmx 214 10 CD8ϩ CD8ϩ NNP cord-348746-yaf61cmx 214 11 T T NNP cord-348746-yaf61cmx 214 12 - - HYPH cord-348746-yaf61cmx 214 13 cells cell NNS cord-348746-yaf61cmx 214 14 , , , cord-348746-yaf61cmx 214 15 suggesting suggest VBG cord-348746-yaf61cmx 214 16 that that IN cord-348746-yaf61cmx 214 17 IFN- IFN- NNP cord-348746-yaf61cmx 214 18 ␥ ␥ NNP cord-348746-yaf61cmx 214 19 is be VBZ cord-348746-yaf61cmx 214 20 necessary necessary JJ cord-348746-yaf61cmx 214 21 for for IN cord-348746-yaf61cmx 214 22 control control NN cord-348746-yaf61cmx 214 23 of of IN cord-348746-yaf61cmx 214 24 viral viral JJ cord-348746-yaf61cmx 214 25 replication replication NN cord-348746-yaf61cmx 214 26 in in IN cord-348746-yaf61cmx 214 27 oligodendrocytes oligodendrocyte NNS cord-348746-yaf61cmx 214 28 . . . cord-348746-yaf61cmx 215 1 Treatment treatment NN cord-348746-yaf61cmx 215 2 of of IN cord-348746-yaf61cmx 215 3 mice mouse NNS cord-348746-yaf61cmx 215 4 with with IN cord-348746-yaf61cmx 215 5 anti anti JJ cord-348746-yaf61cmx 215 6 - - JJ cord-348746-yaf61cmx 215 7 IFN- ifn- JJ cord-348746-yaf61cmx 215 8 ␥ ␥ CD cord-348746-yaf61cmx 215 9 antibody antibody NN cord-348746-yaf61cmx 215 10 increased increase VBD cord-348746-yaf61cmx 215 11 the the DT cord-348746-yaf61cmx 215 12 mortality mortality NN cord-348746-yaf61cmx 215 13 rate rate NN cord-348746-yaf61cmx 215 14 of of IN cord-348746-yaf61cmx 215 15 mice mouse NNS cord-348746-yaf61cmx 215 16 , , , cord-348746-yaf61cmx 215 17 whereas whereas IN cord-348746-yaf61cmx 215 18 immunotherapy immunotherapy NN cord-348746-yaf61cmx 215 19 with with IN cord-348746-yaf61cmx 215 20 IFN- IFN- NNP cord-348746-yaf61cmx 215 21 ␥ ␥ NNP cord-348746-yaf61cmx 215 22 reduced reduce VBN cord-348746-yaf61cmx 215 23 mortality mortality NN cord-348746-yaf61cmx 215 24 and and CC cord-348746-yaf61cmx 215 25 virus virus NN cord-348746-yaf61cmx 215 26 load load NN cord-348746-yaf61cmx 215 27 . . . cord-348746-yaf61cmx 216 1 86 86 CD cord-348746-yaf61cmx 217 1 MHV MHV NNP cord-348746-yaf61cmx 217 2 - - HYPH cord-348746-yaf61cmx 217 3 OBLV60 OBLV60 NNP cord-348746-yaf61cmx 217 4 infection infection NN cord-348746-yaf61cmx 217 5 in in IN cord-348746-yaf61cmx 217 6 immunocompetent immunocompetent JJ cord-348746-yaf61cmx 217 7 mice mouse NNS cord-348746-yaf61cmx 217 8 induced induce VBD cord-348746-yaf61cmx 217 9 transient transient JJ cord-348746-yaf61cmx 217 10 mRNA mrna NN cord-348746-yaf61cmx 217 11 upregulation upregulation NN cord-348746-yaf61cmx 217 12 for for IN cord-348746-yaf61cmx 217 13 cytokines cytokine NNS cord-348746-yaf61cmx 218 1 IL-1 IL-1 NNP cord-348746-yaf61cmx 219 1 ␣ ␣ NNP cord-348746-yaf61cmx 219 2 , , , cord-348746-yaf61cmx 219 3 IL-1 IL-1 NNP cord-348746-yaf61cmx 219 4 ␤ ␤ NNP cord-348746-yaf61cmx 219 5 , , , cord-348746-yaf61cmx 220 1 IL-6 IL-6 NNP cord-348746-yaf61cmx 220 2 , , , cord-348746-yaf61cmx 220 3 TNF- TNF- NNP cord-348746-yaf61cmx 220 4 ␣ ␣ NN cord-348746-yaf61cmx 220 5 , , , cord-348746-yaf61cmx 220 6 and and CC cord-348746-yaf61cmx 220 7 IFN- IFN- NNP cord-348746-yaf61cmx 220 8 ␥ ␥ NNP cord-348746-yaf61cmx 220 9 . . . cord-348746-yaf61cmx 220 10 25 25 CD cord-348746-yaf61cmx 220 11 Nude nude JJ cord-348746-yaf61cmx 220 12 mice mouse NNS cord-348746-yaf61cmx 220 13 differed differ VBD cord-348746-yaf61cmx 220 14 in in IN cord-348746-yaf61cmx 220 15 their -PRON- PRP$ cord-348746-yaf61cmx 220 16 cytokine cytokine NN cord-348746-yaf61cmx 220 17 profiles profile NNS cord-348746-yaf61cmx 220 18 in in IN cord-348746-yaf61cmx 220 19 that that IN cord-348746-yaf61cmx 220 20 they -PRON- PRP cord-348746-yaf61cmx 220 21 lacked lack VBD cord-348746-yaf61cmx 220 22 mRNA mrna NN cord-348746-yaf61cmx 220 23 for for IN cord-348746-yaf61cmx 220 24 IFN- IFN- NNP cord-348746-yaf61cmx 220 25 ␥ ␥ NNP cord-348746-yaf61cmx 220 26 , , , cord-348746-yaf61cmx 220 27 whereas whereas IN cord-348746-yaf61cmx 220 28 concentrations concentration NNS cord-348746-yaf61cmx 220 29 of of IN cord-348746-yaf61cmx 220 30 the the DT cord-348746-yaf61cmx 220 31 other other JJ cord-348746-yaf61cmx 220 32 cytokines cytokine NNS cord-348746-yaf61cmx 220 33 remained remain VBD cord-348746-yaf61cmx 220 34 persistently persistently RB cord-348746-yaf61cmx 220 35 high high JJ cord-348746-yaf61cmx 220 36 . . . cord-348746-yaf61cmx 221 1 The the DT cord-348746-yaf61cmx 221 2 authors author NNS cord-348746-yaf61cmx 221 3 suggested suggest VBD cord-348746-yaf61cmx 221 4 that that IN cord-348746-yaf61cmx 221 5 the the DT cord-348746-yaf61cmx 221 6 increased increase VBN cord-348746-yaf61cmx 221 7 cytokines cytokine NNS cord-348746-yaf61cmx 221 8 in in IN cord-348746-yaf61cmx 221 9 the the DT cord-348746-yaf61cmx 221 10 nude nude JJ cord-348746-yaf61cmx 221 11 mice mouse NNS cord-348746-yaf61cmx 221 12 were be VBD cord-348746-yaf61cmx 221 13 produced produce VBN cord-348746-yaf61cmx 221 14 by by IN cord-348746-yaf61cmx 221 15 CNS CNS NNP cord-348746-yaf61cmx 221 16 glial glial JJ cord-348746-yaf61cmx 221 17 cells cell NNS cord-348746-yaf61cmx 221 18 and and CC cord-348746-yaf61cmx 221 19 possibly possibly RB cord-348746-yaf61cmx 221 20 CD4ϩ CD4ϩ NNP cord-348746-yaf61cmx 221 21 and and CC cord-348746-yaf61cmx 221 22 CD8ϩ CD8ϩ NNP cord-348746-yaf61cmx 221 23 subsets subset NNS cord-348746-yaf61cmx 221 24 . . . cord-348746-yaf61cmx 222 1 IFN- IFN- NNP cord-348746-yaf61cmx 222 2 ␥ ␥ CD cord-348746-yaf61cmx 222 3 treatment treatment NN cord-348746-yaf61cmx 222 4 of of IN cord-348746-yaf61cmx 222 5 human human JJ cord-348746-yaf61cmx 222 6 neuronal neuronal JJ cord-348746-yaf61cmx 222 7 cell cell NN cord-348746-yaf61cmx 222 8 cultures culture NNS cord-348746-yaf61cmx 222 9 markedly markedly RB cord-348746-yaf61cmx 222 10 increased increase VBD cord-348746-yaf61cmx 222 11 the the DT cord-348746-yaf61cmx 222 12 susceptibility susceptibility NN cord-348746-yaf61cmx 222 13 of of IN cord-348746-yaf61cmx 222 14 cells cell NNS cord-348746-yaf61cmx 222 15 to to IN cord-348746-yaf61cmx 222 16 infection infection NN cord-348746-yaf61cmx 222 17 with with IN cord-348746-yaf61cmx 222 18 HCV HCV NNP cord-348746-yaf61cmx 222 19 - - HYPH cord-348746-yaf61cmx 222 20 OC43 OC43 NNP cord-348746-yaf61cmx 222 21 ( ( -LRB- cord-348746-yaf61cmx 222 22 although although IN cord-348746-yaf61cmx 222 23 cells cell NNS cord-348746-yaf61cmx 222 24 were be VBD cord-348746-yaf61cmx 222 25 susceptible susceptible JJ cord-348746-yaf61cmx 222 26 to to IN cord-348746-yaf61cmx 222 27 229E 229e CD cord-348746-yaf61cmx 222 28 without without IN cord-348746-yaf61cmx 222 29 IFN- IFN- NNP cord-348746-yaf61cmx 222 30 ␥ ␥ CD cord-348746-yaf61cmx 222 31 treatment treatment NN cord-348746-yaf61cmx 222 32 ) ) -RRB- cord-348746-yaf61cmx 222 33 . . . cord-348746-yaf61cmx 223 1 87 87 CD cord-348746-yaf61cmx 224 1 In in IN cord-348746-yaf61cmx 224 2 this this DT cord-348746-yaf61cmx 224 3 study study NN cord-348746-yaf61cmx 224 4 , , , cord-348746-yaf61cmx 224 5 the the DT cord-348746-yaf61cmx 224 6 hypothesized hypothesize VBN cord-348746-yaf61cmx 224 7 role role NN cord-348746-yaf61cmx 224 8 of of IN cord-348746-yaf61cmx 224 9 IFN- IFN- NNP cord-348746-yaf61cmx 224 10 ␥ ␥ NNP cord-348746-yaf61cmx 224 11 was be VBD cord-348746-yaf61cmx 224 12 induction induction NN cord-348746-yaf61cmx 224 13 of of IN cord-348746-yaf61cmx 224 14 MHC MHC NNP cord-348746-yaf61cmx 224 15 class class NN cord-348746-yaf61cmx 224 16 I -PRON- PRP cord-348746-yaf61cmx 224 17 expression expression NN cord-348746-yaf61cmx 224 18 . . . cord-348746-yaf61cmx 225 1 IFN- IFN- NNP cord-348746-yaf61cmx 225 2 ␥ ␥ NNP cord-348746-yaf61cmx 225 3 may may MD cord-348746-yaf61cmx 225 4 increase increase VB cord-348746-yaf61cmx 225 5 superoxide superoxide NN cord-348746-yaf61cmx 225 6 dismutase dismutase NN cord-348746-yaf61cmx 225 7 and and CC cord-348746-yaf61cmx 225 8 protect protect VB cord-348746-yaf61cmx 225 9 against against IN cord-348746-yaf61cmx 225 10 oxygen oxygen NN cord-348746-yaf61cmx 225 11 radicals radical NNS cord-348746-yaf61cmx 225 12 , , , cord-348746-yaf61cmx 225 13 kill kill VB cord-348746-yaf61cmx 225 14 virus virus NN cord-348746-yaf61cmx 225 15 directly directly RB cord-348746-yaf61cmx 225 16 , , , cord-348746-yaf61cmx 225 17 and and CC cord-348746-yaf61cmx 225 18 increase increase VB cord-348746-yaf61cmx 225 19 the the DT cord-348746-yaf61cmx 225 20 cytotoxicity cytotoxicity NN cord-348746-yaf61cmx 225 21 of of IN cord-348746-yaf61cmx 225 22 other other JJ cord-348746-yaf61cmx 225 23 effector effector NN cord-348746-yaf61cmx 225 24 cells cell NNS cord-348746-yaf61cmx 225 25 . . . cord-348746-yaf61cmx 226 1 The the DT cord-348746-yaf61cmx 226 2 chemokine chemokine NN cord-348746-yaf61cmx 226 3 CRG-2 CRG-2 NNP cord-348746-yaf61cmx 226 4 is be VBZ cord-348746-yaf61cmx 226 5 expressed express VBN cord-348746-yaf61cmx 226 6 primarily primarily RB cord-348746-yaf61cmx 226 7 by by IN cord-348746-yaf61cmx 226 8 astrocytes astrocyte NNS cord-348746-yaf61cmx 226 9 during during IN cord-348746-yaf61cmx 226 10 MHV MHV NNP cord-348746-yaf61cmx 226 11 infection infection NN cord-348746-yaf61cmx 226 12 and and CC cord-348746-yaf61cmx 226 13 co co NNS cord-348746-yaf61cmx 226 14 - - NN cord-348746-yaf61cmx 226 15 localizes localize VBZ cord-348746-yaf61cmx 226 16 with with IN cord-348746-yaf61cmx 226 17 areas area NNS cord-348746-yaf61cmx 226 18 of of IN cord-348746-yaf61cmx 226 19 viral viral JJ cord-348746-yaf61cmx 226 20 RNA rna NN cord-348746-yaf61cmx 226 21 and and CC cord-348746-yaf61cmx 226 22 demyelination demyelination NN cord-348746-yaf61cmx 226 23 . . . cord-348746-yaf61cmx 227 1 88 88 CD cord-348746-yaf61cmx 228 1 The the DT cord-348746-yaf61cmx 228 2 function function NN cord-348746-yaf61cmx 228 3 of of IN cord-348746-yaf61cmx 228 4 CRG-2 CRG-2 NNP cord-348746-yaf61cmx 228 5 is be VBZ cord-348746-yaf61cmx 228 6 not not RB cord-348746-yaf61cmx 228 7 known know VBN cord-348746-yaf61cmx 228 8 , , , cord-348746-yaf61cmx 228 9 but but CC cord-348746-yaf61cmx 228 10 this this DT cord-348746-yaf61cmx 228 11 chemokine chemokine NN cord-348746-yaf61cmx 228 12 is be VBZ cord-348746-yaf61cmx 228 13 also also RB cord-348746-yaf61cmx 228 14 found find VBN cord-348746-yaf61cmx 228 15 in in IN cord-348746-yaf61cmx 228 16 simian simian JJ cord-348746-yaf61cmx 228 17 immunodeficiency immunodeficiency NN cord-348746-yaf61cmx 228 18 viral viral NN cord-348746-yaf61cmx 228 19 ( ( -LRB- cord-348746-yaf61cmx 228 20 SIV SIV NNP cord-348746-yaf61cmx 228 21 ) ) -RRB- cord-348746-yaf61cmx 228 22 encephalitis encephalitis NN cord-348746-yaf61cmx 228 23 89 89 CD cord-348746-yaf61cmx 228 24 and and CC cord-348746-yaf61cmx 228 25 lymphocytic lymphocytic JJ cord-348746-yaf61cmx 228 26 choriomeningitis choriomeningitis NNP cord-348746-yaf61cmx 228 27 . . . cord-348746-yaf61cmx 229 1 90 90 CD cord-348746-yaf61cmx 230 1 With with IN cord-348746-yaf61cmx 230 2 very very RB cord-348746-yaf61cmx 230 3 little little JJ cord-348746-yaf61cmx 230 4 information information NN cord-348746-yaf61cmx 230 5 available available JJ cord-348746-yaf61cmx 230 6 about about IN cord-348746-yaf61cmx 230 7 the the DT cord-348746-yaf61cmx 230 8 immunopathogenesis immunopathogenesis NN cord-348746-yaf61cmx 230 9 of of IN cord-348746-yaf61cmx 230 10 neurologic neurologic JJ cord-348746-yaf61cmx 230 11 FIP FIP NNP cord-348746-yaf61cmx 230 12 , , , cord-348746-yaf61cmx 230 13 research research NN cord-348746-yaf61cmx 230 14 performed perform VBN cord-348746-yaf61cmx 230 15 in in IN cord-348746-yaf61cmx 230 16 mice mouse NNS cord-348746-yaf61cmx 230 17 can can MD cord-348746-yaf61cmx 230 18 be be VB cord-348746-yaf61cmx 230 19 used use VBN cord-348746-yaf61cmx 230 20 as as IN cord-348746-yaf61cmx 230 21 a a DT cord-348746-yaf61cmx 230 22 model model NN cord-348746-yaf61cmx 230 23 for for IN cord-348746-yaf61cmx 230 24 FIP FIP NNP cord-348746-yaf61cmx 230 25 and and CC cord-348746-yaf61cmx 230 26 to to TO cord-348746-yaf61cmx 230 27 contrast contrast VB cord-348746-yaf61cmx 230 28 findings finding NNS cord-348746-yaf61cmx 230 29 from from IN cord-348746-yaf61cmx 230 30 the the DT cord-348746-yaf61cmx 230 31 MHV MHV NNP cord-348746-yaf61cmx 230 32 model model NN cord-348746-yaf61cmx 230 33 with with IN cord-348746-yaf61cmx 230 34 those those DT cord-348746-yaf61cmx 230 35 in in IN cord-348746-yaf61cmx 230 36 FIP FIP NNP cord-348746-yaf61cmx 230 37 . . . cord-348746-yaf61cmx 231 1 The the DT cord-348746-yaf61cmx 231 2 immunopathogenic immunopathogenic JJ cord-348746-yaf61cmx 231 3 mechanisms mechanism NNS cord-348746-yaf61cmx 231 4 are be VBP cord-348746-yaf61cmx 231 5 expected expect VBN cord-348746-yaf61cmx 231 6 to to TO cord-348746-yaf61cmx 231 7 have have VB cord-348746-yaf61cmx 231 8 important important JJ cord-348746-yaf61cmx 231 9 similarities similarity NNS cord-348746-yaf61cmx 231 10 , , , cord-348746-yaf61cmx 231 11 but but CC cord-348746-yaf61cmx 231 12 the the DT cord-348746-yaf61cmx 231 13 demyelination demyelination NN cord-348746-yaf61cmx 231 14 that that WDT cord-348746-yaf61cmx 231 15 occurs occur VBZ cord-348746-yaf61cmx 231 16 in in IN cord-348746-yaf61cmx 231 17 MHV MHV NNP cord-348746-yaf61cmx 231 18 is be VBZ cord-348746-yaf61cmx 231 19 a a DT cord-348746-yaf61cmx 231 20 more more RBR cord-348746-yaf61cmx 231 21 extensive extensive JJ cord-348746-yaf61cmx 231 22 pathological pathological JJ cord-348746-yaf61cmx 231 23 sequela sequela NN cord-348746-yaf61cmx 231 24 of of IN cord-348746-yaf61cmx 231 25 coronaviral coronaviral JJ cord-348746-yaf61cmx 231 26 infection infection NN cord-348746-yaf61cmx 231 27 ( ( -LRB- cord-348746-yaf61cmx 231 28 but but CC cord-348746-yaf61cmx 231 29 not not RB cord-348746-yaf61cmx 231 30 more more RBR cord-348746-yaf61cmx 231 31 fatal fatal JJ cord-348746-yaf61cmx 231 32 for for IN cord-348746-yaf61cmx 231 33 the the DT cord-348746-yaf61cmx 231 34 patient patient NN cord-348746-yaf61cmx 231 35 ) ) -RRB- cord-348746-yaf61cmx 231 36 than than IN cord-348746-yaf61cmx 231 37 the the DT cord-348746-yaf61cmx 231 38 focal focal JJ cord-348746-yaf61cmx 231 39 granulomas granuloma NNS cord-348746-yaf61cmx 231 40 that that WDT cord-348746-yaf61cmx 231 41 occur occur VBP cord-348746-yaf61cmx 231 42 in in IN cord-348746-yaf61cmx 231 43 FIP FIP NNP cord-348746-yaf61cmx 231 44 . . . cord-348746-yaf61cmx 232 1 It -PRON- PRP cord-348746-yaf61cmx 232 2 can can MD cord-348746-yaf61cmx 232 3 be be VB cord-348746-yaf61cmx 232 4 hypothesized hypothesize VBN cord-348746-yaf61cmx 232 5 that that IN cord-348746-yaf61cmx 232 6 in in IN cord-348746-yaf61cmx 232 7 FIP FIP NNP cord-348746-yaf61cmx 232 8 , , , cord-348746-yaf61cmx 232 9 upregulation upregulation NN cord-348746-yaf61cmx 232 10 of of IN cord-348746-yaf61cmx 232 11 cytokines cytokine NNS cord-348746-yaf61cmx 232 12 IL-1 IL-1 NNP cord-348746-yaf61cmx 232 13 ␤ ␤ NNP cord-348746-yaf61cmx 232 14 , , , cord-348746-yaf61cmx 232 15 IL-6 IL-6 NNP cord-348746-yaf61cmx 232 16 , , , cord-348746-yaf61cmx 232 17 IFN- IFN- NNP cord-348746-yaf61cmx 232 18 ␥ ␥ NNP cord-348746-yaf61cmx 232 19 , , , cord-348746-yaf61cmx 232 20 and and CC cord-348746-yaf61cmx 232 21 TNF- TNF- NNP cord-348746-yaf61cmx 232 22 ␣ ␣ NN cord-348746-yaf61cmx 232 23 may may MD cord-348746-yaf61cmx 232 24 be be VB cord-348746-yaf61cmx 232 25 important important JJ cord-348746-yaf61cmx 232 26 in in IN cord-348746-yaf61cmx 232 27 mediation mediation NN cord-348746-yaf61cmx 232 28 of of IN cord-348746-yaf61cmx 232 29 destructive destructive JJ cord-348746-yaf61cmx 232 30 inflammation inflammation NN cord-348746-yaf61cmx 232 31 , , , cord-348746-yaf61cmx 232 32 but but CC cord-348746-yaf61cmx 232 33 cytokines cytokine NNS cord-348746-yaf61cmx 232 34 IL-6 IL-6 NNP cord-348746-yaf61cmx 232 35 and and CC cord-348746-yaf61cmx 232 36 IFN- IFN- NNP cord-348746-yaf61cmx 232 37 ␥ ␥ XX cord-348746-yaf61cmx 232 38 may may MD cord-348746-yaf61cmx 232 39 be be VB cord-348746-yaf61cmx 232 40 important important JJ cord-348746-yaf61cmx 232 41 in in IN cord-348746-yaf61cmx 232 42 controlling control VBG cord-348746-yaf61cmx 232 43 viral viral JJ cord-348746-yaf61cmx 232 44 infection infection NN cord-348746-yaf61cmx 232 45 , , , cord-348746-yaf61cmx 232 46 despite despite IN cord-348746-yaf61cmx 232 47 adverse adverse JJ cord-348746-yaf61cmx 232 48 inflammatory inflammatory JJ cord-348746-yaf61cmx 232 49 effects effect NNS cord-348746-yaf61cmx 232 50 . . . cord-348746-yaf61cmx 233 1 Cytokine cytokine NN cord-348746-yaf61cmx 233 2 and and CC cord-348746-yaf61cmx 233 3 chemokine chemokine NN cord-348746-yaf61cmx 233 4 alterations alteration NNS cord-348746-yaf61cmx 233 5 in in IN cord-348746-yaf61cmx 233 6 the the DT cord-348746-yaf61cmx 233 7 brains brain NNS cord-348746-yaf61cmx 233 8 of of IN cord-348746-yaf61cmx 233 9 mice mouse NNS cord-348746-yaf61cmx 233 10 and and CC cord-348746-yaf61cmx 233 11 cats cat NNS cord-348746-yaf61cmx 233 12 with with IN cord-348746-yaf61cmx 233 13 coronavirus coronavirus NN cord-348746-yaf61cmx 233 14 infections infection NNS cord-348746-yaf61cmx 233 15 may may MD cord-348746-yaf61cmx 233 16 provide provide VB cord-348746-yaf61cmx 233 17 valuable valuable JJ cord-348746-yaf61cmx 233 18 clues clue NNS cord-348746-yaf61cmx 233 19 to to IN cord-348746-yaf61cmx 233 20 the the DT cord-348746-yaf61cmx 233 21 immunopathogenesis immunopathogenesis NN cord-348746-yaf61cmx 233 22 of of IN cord-348746-yaf61cmx 233 23 these these DT cord-348746-yaf61cmx 233 24 diseases disease NNS cord-348746-yaf61cmx 233 25 , , , cord-348746-yaf61cmx 233 26 as as RB cord-348746-yaf61cmx 233 27 well well RB cord-348746-yaf61cmx 233 28 as as IN cord-348746-yaf61cmx 233 29 possible possible JJ cord-348746-yaf61cmx 233 30 diagnostic diagnostic JJ cord-348746-yaf61cmx 233 31 markers marker NNS cord-348746-yaf61cmx 233 32 and and CC cord-348746-yaf61cmx 233 33 targets target NNS cord-348746-yaf61cmx 233 34 for for IN cord-348746-yaf61cmx 233 35 immunological immunological JJ cord-348746-yaf61cmx 233 36 treatment treatment NN cord-348746-yaf61cmx 233 37 of of IN cord-348746-yaf61cmx 233 38 disease disease NN cord-348746-yaf61cmx 233 39 . . . cord-348746-yaf61cmx 234 1 It -PRON- PRP cord-348746-yaf61cmx 234 2 is be VBZ cord-348746-yaf61cmx 234 3 tempting tempt VBG cord-348746-yaf61cmx 234 4 to to TO cord-348746-yaf61cmx 234 5 consider consider VB cord-348746-yaf61cmx 234 6 cytokine cytokine JJ cord-348746-yaf61cmx 234 7 modulation modulation NN cord-348746-yaf61cmx 234 8 in in IN cord-348746-yaf61cmx 234 9 the the DT cord-348746-yaf61cmx 234 10 treatment treatment NN cord-348746-yaf61cmx 234 11 of of IN cord-348746-yaf61cmx 234 12 FIP FIP NNP cord-348746-yaf61cmx 234 13 , , , cord-348746-yaf61cmx 234 14 but but CC cord-348746-yaf61cmx 234 15 this this DT cord-348746-yaf61cmx 234 16 application application NN cord-348746-yaf61cmx 234 17 is be VBZ cord-348746-yaf61cmx 234 18 premature premature JJ cord-348746-yaf61cmx 234 19 without without IN cord-348746-yaf61cmx 234 20 information information NN cord-348746-yaf61cmx 234 21 regarding regard VBG cord-348746-yaf61cmx 234 22 the the DT cord-348746-yaf61cmx 234 23 cytokine cytokine NN cord-348746-yaf61cmx 234 24 profiles profile NNS cord-348746-yaf61cmx 234 25 of of IN cord-348746-yaf61cmx 234 26 affected affected JJ cord-348746-yaf61cmx 234 27 cats cat NNS cord-348746-yaf61cmx 234 28 . . . cord-348746-yaf61cmx 235 1 In in IN cord-348746-yaf61cmx 235 2 addition addition NN cord-348746-yaf61cmx 235 3 to to IN cord-348746-yaf61cmx 235 4 characterizing characterize VBG cord-348746-yaf61cmx 235 5 the the DT cord-348746-yaf61cmx 235 6 concentrations concentration NNS cord-348746-yaf61cmx 235 7 of of IN cord-348746-yaf61cmx 235 8 cytokines cytokine NNS cord-348746-yaf61cmx 235 9 in in IN cord-348746-yaf61cmx 235 10 the the DT cord-348746-yaf61cmx 235 11 CNS CNS NNP cord-348746-yaf61cmx 235 12 of of IN cord-348746-yaf61cmx 235 13 cats cat NNS cord-348746-yaf61cmx 235 14 with with IN cord-348746-yaf61cmx 235 15 FIP FIP NNP cord-348746-yaf61cmx 235 16 , , , cord-348746-yaf61cmx 235 17 it -PRON- PRP cord-348746-yaf61cmx 235 18 will will MD cord-348746-yaf61cmx 235 19 be be VB cord-348746-yaf61cmx 235 20 important important JJ cord-348746-yaf61cmx 235 21 to to TO cord-348746-yaf61cmx 235 22 describe describe VB cord-348746-yaf61cmx 235 23 the the DT cord-348746-yaf61cmx 235 24 timing timing NN cord-348746-yaf61cmx 235 25 of of IN cord-348746-yaf61cmx 235 26 upregulated upregulated JJ cord-348746-yaf61cmx 235 27 cytokine cytokine NN cord-348746-yaf61cmx 235 28 transcription transcription NN cord-348746-yaf61cmx 235 29 . . . cord-348746-yaf61cmx 236 1 In in IN cord-348746-yaf61cmx 236 2 mice mouse NNS cord-348746-yaf61cmx 236 3 with with IN cord-348746-yaf61cmx 236 4 HMV HMV NNP cord-348746-yaf61cmx 236 5 - - HYPH cord-348746-yaf61cmx 236 6 JHM JHM NNP cord-348746-yaf61cmx 236 7 , , , cord-348746-yaf61cmx 236 8 treatment treatment NN cord-348746-yaf61cmx 236 9 with with IN cord-348746-yaf61cmx 236 10 recombinant recombinant JJ cord-348746-yaf61cmx 236 11 IFN- IFN- NNP cord-348746-yaf61cmx 236 12 ␥ ␥ NNP cord-348746-yaf61cmx 236 13 resulted result VBD cord-348746-yaf61cmx 236 14 in in IN cord-348746-yaf61cmx 236 15 reduced reduce VBN cord-348746-yaf61cmx 236 16 virus virus NN cord-348746-yaf61cmx 236 17 load load NN cord-348746-yaf61cmx 236 18 in in IN cord-348746-yaf61cmx 236 19 the the DT cord-348746-yaf61cmx 236 20 liver liver NN cord-348746-yaf61cmx 236 21 but but CC cord-348746-yaf61cmx 236 22 not not RB cord-348746-yaf61cmx 236 23 in in IN cord-348746-yaf61cmx 236 24 the the DT cord-348746-yaf61cmx 236 25 brain brain NN cord-348746-yaf61cmx 236 26 . . . cord-348746-yaf61cmx 237 1 86 86 CD cord-348746-yaf61cmx 238 1 If if IN cord-348746-yaf61cmx 238 2 specific specific JJ cord-348746-yaf61cmx 238 3 pro pro JJ cord-348746-yaf61cmx 238 4 - - JJ cord-348746-yaf61cmx 238 5 inflammatory inflammatory JJ cord-348746-yaf61cmx 238 6 cytokines cytokine NNS cord-348746-yaf61cmx 238 7 are be VBP cord-348746-yaf61cmx 238 8 found find VBN cord-348746-yaf61cmx 238 9 to to TO cord-348746-yaf61cmx 238 10 be be VB cord-348746-yaf61cmx 238 11 consistently consistently RB cord-348746-yaf61cmx 238 12 high high JJ cord-348746-yaf61cmx 238 13 in in IN cord-348746-yaf61cmx 238 14 cats cat NNS cord-348746-yaf61cmx 238 15 with with IN cord-348746-yaf61cmx 238 16 neurological neurological JJ cord-348746-yaf61cmx 238 17 FIP fip NN cord-348746-yaf61cmx 238 18 , , , cord-348746-yaf61cmx 238 19 use use NN cord-348746-yaf61cmx 238 20 of of IN cord-348746-yaf61cmx 238 21 cytokine cytokine JJ cord-348746-yaf61cmx 238 22 antagonists antagonist NNS cord-348746-yaf61cmx 238 23 may may MD cord-348746-yaf61cmx 238 24 eventually eventually RB cord-348746-yaf61cmx 238 25 be be VB cord-348746-yaf61cmx 238 26 of of IN cord-348746-yaf61cmx 238 27 benefit benefit NN cord-348746-yaf61cmx 238 28 in in IN cord-348746-yaf61cmx 238 29 treatment treatment NN cord-348746-yaf61cmx 238 30 . . . cord-348746-yaf61cmx 239 1 Successful successful JJ cord-348746-yaf61cmx 239 2 management management NN cord-348746-yaf61cmx 239 3 of of IN cord-348746-yaf61cmx 239 4 FIP FIP NNP cord-348746-yaf61cmx 239 5 may may MD cord-348746-yaf61cmx 239 6 consist consist VB cord-348746-yaf61cmx 239 7 of of IN cord-348746-yaf61cmx 239 8 better well JJR cord-348746-yaf61cmx 239 9 methods method NNS cord-348746-yaf61cmx 239 10 of of IN cord-348746-yaf61cmx 239 11 prevention prevention NN cord-348746-yaf61cmx 239 12 as as RB cord-348746-yaf61cmx 239 13 well well RB cord-348746-yaf61cmx 239 14 as as IN cord-348746-yaf61cmx 239 15 management management NN cord-348746-yaf61cmx 239 16 of of IN cord-348746-yaf61cmx 239 17 disease disease NN cord-348746-yaf61cmx 239 18 once once IN cord-348746-yaf61cmx 239 19 it -PRON- PRP cord-348746-yaf61cmx 239 20 occurs occur VBZ cord-348746-yaf61cmx 239 21 . . . cord-348746-yaf61cmx 240 1 A a DT cord-348746-yaf61cmx 240 2 commercial commercial JJ cord-348746-yaf61cmx 240 3 FIP fip NN cord-348746-yaf61cmx 240 4 vaccine vaccine NN cord-348746-yaf61cmx 240 5 is be VBZ cord-348746-yaf61cmx 240 6 available available JJ cord-348746-yaf61cmx 240 7 that that WDT cord-348746-yaf61cmx 240 8 consists consist VBZ cord-348746-yaf61cmx 240 9 of of IN cord-348746-yaf61cmx 240 10 a a DT cord-348746-yaf61cmx 240 11 mucosally mucosally RB cord-348746-yaf61cmx 240 12 delivered deliver VBN cord-348746-yaf61cmx 240 13 , , , cord-348746-yaf61cmx 240 14 temperature temperature NN cord-348746-yaf61cmx 240 15 - - HYPH cord-348746-yaf61cmx 240 16 sensitive sensitive JJ cord-348746-yaf61cmx 240 17 mutant mutant JJ cord-348746-yaf61cmx 240 18 form form NN cord-348746-yaf61cmx 240 19 of of IN cord-348746-yaf61cmx 240 20 FIPV FIPV NNS cord-348746-yaf61cmx 240 21 . . . cord-348746-yaf61cmx 241 1 The the DT cord-348746-yaf61cmx 241 2 vaccine vaccine NN cord-348746-yaf61cmx 241 3 virus virus NN cord-348746-yaf61cmx 241 4 is be VBZ cord-348746-yaf61cmx 241 5 supposed suppose VBN cord-348746-yaf61cmx 241 6 to to TO cord-348746-yaf61cmx 241 7 undergo undergo VB cord-348746-yaf61cmx 241 8 replication replication NN cord-348746-yaf61cmx 241 9 only only RB cord-348746-yaf61cmx 241 10 in in IN cord-348746-yaf61cmx 241 11 outer outer JJ cord-348746-yaf61cmx 241 12 oronasal oronasal NN cord-348746-yaf61cmx 241 13 cavities cavity NNS cord-348746-yaf61cmx 241 14 at at IN cord-348746-yaf61cmx 241 15 low low JJ cord-348746-yaf61cmx 241 16 temperatures temperature NNS cord-348746-yaf61cmx 241 17 , , , cord-348746-yaf61cmx 241 18 thus thus RB cord-348746-yaf61cmx 241 19 triggering trigger VBG cord-348746-yaf61cmx 241 20 protective protective JJ cord-348746-yaf61cmx 241 21 antibodies antibody NNS cord-348746-yaf61cmx 241 22 but but CC cord-348746-yaf61cmx 241 23 not not RB cord-348746-yaf61cmx 241 24 FIP FIP NNP cord-348746-yaf61cmx 241 25 . . . cord-348746-yaf61cmx 242 1 A a DT cord-348746-yaf61cmx 242 2 few few JJ cord-348746-yaf61cmx 242 3 controversial controversial JJ cord-348746-yaf61cmx 242 4 studies study NNS cord-348746-yaf61cmx 242 5 have have VBP cord-348746-yaf61cmx 242 6 documented document VBN cord-348746-yaf61cmx 242 7 reduction reduction NN cord-348746-yaf61cmx 242 8 in in IN cord-348746-yaf61cmx 242 9 FIP FIP NNP cord-348746-yaf61cmx 242 10 as as IN cord-348746-yaf61cmx 242 11 a a DT cord-348746-yaf61cmx 242 12 result result NN cord-348746-yaf61cmx 242 13 of of IN cord-348746-yaf61cmx 242 14 vaccination vaccination NN cord-348746-yaf61cmx 242 15 . . . cord-348746-yaf61cmx 243 1 91 91 CD cord-348746-yaf61cmx 243 2 , , , cord-348746-yaf61cmx 243 3 92 92 CD cord-348746-yaf61cmx 243 4 Many many JJ cord-348746-yaf61cmx 243 5 vaccinated vaccinate VBN cord-348746-yaf61cmx 243 6 cats cat NNS cord-348746-yaf61cmx 243 7 , , , cord-348746-yaf61cmx 243 8 however however RB cord-348746-yaf61cmx 243 9 , , , cord-348746-yaf61cmx 243 10 fail fail VBP cord-348746-yaf61cmx 243 11 to to TO cord-348746-yaf61cmx 243 12 seroconvert seroconvert VB cord-348746-yaf61cmx 243 13 with with IN cord-348746-yaf61cmx 243 14 either either CC cord-348746-yaf61cmx 243 15 IgG IgG NNP cord-348746-yaf61cmx 243 16 or or CC cord-348746-yaf61cmx 243 17 IgA IgA NNP cord-348746-yaf61cmx 243 18 ( ( -LRB- cord-348746-yaf61cmx 243 19 Foley Foley NNP cord-348746-yaf61cmx 243 20 and and CC cord-348746-yaf61cmx 243 21 Pedersen Pedersen NNP cord-348746-yaf61cmx 243 22 , , , cord-348746-yaf61cmx 243 23 unpublished unpublished JJ cord-348746-yaf61cmx 243 24 data datum NNS cord-348746-yaf61cmx 243 25 ) ) -RRB- cord-348746-yaf61cmx 243 26 , , , cord-348746-yaf61cmx 243 27 and and CC cord-348746-yaf61cmx 243 28 independent independent JJ cord-348746-yaf61cmx 243 29 studies study NNS cord-348746-yaf61cmx 243 30 failed fail VBD cord-348746-yaf61cmx 243 31 to to TO cord-348746-yaf61cmx 243 32 identify identify VB cord-348746-yaf61cmx 243 33 vaccine vaccine NN cord-348746-yaf61cmx 243 34 efficacy efficacy NN cord-348746-yaf61cmx 243 35 . . . cord-348746-yaf61cmx 244 1 93 93 CD cord-348746-yaf61cmx 244 2 , , , cord-348746-yaf61cmx 244 3 94 94 CD cord-348746-yaf61cmx 244 4 Other other JJ cord-348746-yaf61cmx 244 5 vaccines vaccine NNS cord-348746-yaf61cmx 244 6 , , , cord-348746-yaf61cmx 244 7 including include VBG cord-348746-yaf61cmx 244 8 DNA dna NN cord-348746-yaf61cmx 244 9 vaccines vaccine NNS cord-348746-yaf61cmx 244 10 , , , cord-348746-yaf61cmx 244 11 have have VBP cord-348746-yaf61cmx 244 12 not not RB cord-348746-yaf61cmx 244 13 progressed progress VBN cord-348746-yaf61cmx 244 14 beyond beyond IN cord-348746-yaf61cmx 244 15 experimental experimental JJ cord-348746-yaf61cmx 244 16 stages stage NNS cord-348746-yaf61cmx 244 17 either either CC cord-348746-yaf61cmx 244 18 because because IN cord-348746-yaf61cmx 244 19 of of IN cord-348746-yaf61cmx 244 20 lack lack NN cord-348746-yaf61cmx 244 21 of of IN cord-348746-yaf61cmx 244 22 seroconversion seroconversion NN cord-348746-yaf61cmx 244 23 , , , cord-348746-yaf61cmx 244 24 lack lack NN cord-348746-yaf61cmx 244 25 of of IN cord-348746-yaf61cmx 244 26 protection protection NN cord-348746-yaf61cmx 244 27 , , , cord-348746-yaf61cmx 244 28 or or CC cord-348746-yaf61cmx 244 29 both both DT cord-348746-yaf61cmx 244 30 . . . cord-348746-yaf61cmx 245 1 In in IN cord-348746-yaf61cmx 245 2 contrast contrast NN cord-348746-yaf61cmx 245 3 with with IN cord-348746-yaf61cmx 245 4 FIP FIP NNP cord-348746-yaf61cmx 245 5 vaccines vaccine NNS cord-348746-yaf61cmx 245 6 , , , cord-348746-yaf61cmx 245 7 vaccines vaccine NNS cord-348746-yaf61cmx 245 8 against against IN cord-348746-yaf61cmx 245 9 MHV MHV NNP cord-348746-yaf61cmx 245 10 have have VBP cord-348746-yaf61cmx 245 11 been be VBN cord-348746-yaf61cmx 245 12 shown show VBN cord-348746-yaf61cmx 245 13 to to TO cord-348746-yaf61cmx 245 14 protect protect VB cord-348746-yaf61cmx 245 15 mice mouse NNS cord-348746-yaf61cmx 245 16 from from IN cord-348746-yaf61cmx 245 17 challenge challenge NN cord-348746-yaf61cmx 245 18 with with IN cord-348746-yaf61cmx 245 19 virulent virulent JJ cord-348746-yaf61cmx 245 20 virus virus NN cord-348746-yaf61cmx 245 21 . . . cord-348746-yaf61cmx 246 1 A a DT cord-348746-yaf61cmx 246 2 vaccine vaccine NN cord-348746-yaf61cmx 246 3 with with IN cord-348746-yaf61cmx 246 4 purified purify VBN cord-348746-yaf61cmx 246 5 spike spike NN cord-348746-yaf61cmx 246 6 protein protein NN cord-348746-yaf61cmx 246 7 95 95 CD cord-348746-yaf61cmx 246 8 and and CC cord-348746-yaf61cmx 246 9 synthetic synthetic JJ cord-348746-yaf61cmx 246 10 S2 s2 NN cord-348746-yaf61cmx 246 11 led lead VBD cord-348746-yaf61cmx 246 12 to to IN cord-348746-yaf61cmx 246 13 neutralizing neutralize VBG cord-348746-yaf61cmx 246 14 antibodies antibody NNS cord-348746-yaf61cmx 246 15 in in IN cord-348746-yaf61cmx 246 16 vivo vivo NN cord-348746-yaf61cmx 246 17 . . . cord-348746-yaf61cmx 247 1 96 96 CD cord-348746-yaf61cmx 247 2 , , , cord-348746-yaf61cmx 247 3 97 97 CD cord-348746-yaf61cmx 247 4 Recombinant recombinant JJ cord-348746-yaf61cmx 247 5 subunits subunit NNS cord-348746-yaf61cmx 247 6 against against IN cord-348746-yaf61cmx 247 7 S S NNP cord-348746-yaf61cmx 247 8 in in IN cord-348746-yaf61cmx 247 9 tobacco tobacco NN cord-348746-yaf61cmx 247 10 mosaic mosaic NN cord-348746-yaf61cmx 247 11 virus virus NN cord-348746-yaf61cmx 247 12 were be VBD cord-348746-yaf61cmx 247 13 given give VBN cord-348746-yaf61cmx 247 14 subcutaneously subcutaneously RB cord-348746-yaf61cmx 247 15 or or CC cord-348746-yaf61cmx 247 16 intranasally intranasally RB cord-348746-yaf61cmx 247 17 and and CC cord-348746-yaf61cmx 247 18 were be VBD cord-348746-yaf61cmx 247 19 protective protective JJ cord-348746-yaf61cmx 247 20 against against IN cord-348746-yaf61cmx 247 21 MHV MHV NNP cord-348746-yaf61cmx 247 22 - - HYPH cord-348746-yaf61cmx 247 23 JHM JHM NNP cord-348746-yaf61cmx 247 24 . . . cord-348746-yaf61cmx 248 1 98 98 CD cord-348746-yaf61cmx 249 1 The the DT cord-348746-yaf61cmx 249 2 current current JJ cord-348746-yaf61cmx 249 3 standard standard NN cord-348746-yaf61cmx 249 4 of of IN cord-348746-yaf61cmx 249 5 care care NN cord-348746-yaf61cmx 249 6 for for IN cord-348746-yaf61cmx 249 7 immunomodulation immunomodulation NN cord-348746-yaf61cmx 249 8 of of IN cord-348746-yaf61cmx 249 9 FIP FIP NNP cord-348746-yaf61cmx 249 10 is be VBZ cord-348746-yaf61cmx 249 11 immunosuppressive immunosuppressive JJ cord-348746-yaf61cmx 249 12 doses dose NNS cord-348746-yaf61cmx 249 13 of of IN cord-348746-yaf61cmx 249 14 prednisone prednisone NN cord-348746-yaf61cmx 249 15 , , , cord-348746-yaf61cmx 249 16 to to TO cord-348746-yaf61cmx 249 17 sustain sustain VB cord-348746-yaf61cmx 249 18 an an DT cord-348746-yaf61cmx 249 19 acceptable acceptable JJ cord-348746-yaf61cmx 249 20 quality quality NN cord-348746-yaf61cmx 249 21 of of IN cord-348746-yaf61cmx 249 22 life life NN cord-348746-yaf61cmx 249 23 for for IN cord-348746-yaf61cmx 249 24 as as RB cord-348746-yaf61cmx 249 25 long long RB cord-348746-yaf61cmx 249 26 as as IN cord-348746-yaf61cmx 249 27 possible possible JJ cord-348746-yaf61cmx 249 28 . . . cord-348746-yaf61cmx 250 1 The the DT cord-348746-yaf61cmx 250 2 effects effect NNS cord-348746-yaf61cmx 250 3 of of IN cord-348746-yaf61cmx 250 4 steroids steroid NNS cord-348746-yaf61cmx 250 5 include include VBP cord-348746-yaf61cmx 250 6 lymphocytolysis lymphocytolysis NNP cord-348746-yaf61cmx 250 7 , , , cord-348746-yaf61cmx 250 8 inhibition inhibition NN cord-348746-yaf61cmx 250 9 of of IN cord-348746-yaf61cmx 250 10 arachidonic arachidonic JJ cord-348746-yaf61cmx 250 11 acid acid NN cord-348746-yaf61cmx 250 12 metabolism metabolism NN cord-348746-yaf61cmx 250 13 , , , cord-348746-yaf61cmx 250 14 reduction reduction NN cord-348746-yaf61cmx 250 15 in in IN cord-348746-yaf61cmx 250 16 cytokine cytokine NN cord-348746-yaf61cmx 250 17 RNA rna NN cord-348746-yaf61cmx 250 18 transcription transcription NN cord-348746-yaf61cmx 250 19 , , , cord-348746-yaf61cmx 250 20 and and CC cord-348746-yaf61cmx 250 21 nitric nitric NN cord-348746-yaf61cmx 250 22 oxide oxide NN cord-348746-yaf61cmx 250 23 synthesis synthesis NN cord-348746-yaf61cmx 250 24 inhibition inhibition NN cord-348746-yaf61cmx 250 25 . . . cord-348746-yaf61cmx 251 1 99 99 CD cord-348746-yaf61cmx 251 2 Other other JJ cord-348746-yaf61cmx 251 3 potentially potentially RB cord-348746-yaf61cmx 251 4 useful useful JJ cord-348746-yaf61cmx 251 5 antiinflammatory antiinflammatory JJ cord-348746-yaf61cmx 251 6 drugs drug NNS cord-348746-yaf61cmx 251 7 include include VBP cord-348746-yaf61cmx 251 8 antileukocyte antileukocyte NNP cord-348746-yaf61cmx 251 9 antibodies antibody NNS cord-348746-yaf61cmx 251 10 and and CC cord-348746-yaf61cmx 251 11 antioxidants antioxidant NNS cord-348746-yaf61cmx 251 12 . . . cord-348746-yaf61cmx 252 1 These these DT cord-348746-yaf61cmx 252 2 treatments treatment NNS cord-348746-yaf61cmx 252 3 are be VBP cord-348746-yaf61cmx 252 4 only only RB cord-348746-yaf61cmx 252 5 palliative palliative JJ cord-348746-yaf61cmx 252 6 . . . cord-348746-yaf61cmx 253 1 A a DT cord-348746-yaf61cmx 253 2 better well JJR cord-348746-yaf61cmx 253 3 understanding understanding NN cord-348746-yaf61cmx 253 4 of of IN cord-348746-yaf61cmx 253 5 the the DT cord-348746-yaf61cmx 253 6 fundamental fundamental JJ cord-348746-yaf61cmx 253 7 pathogenesis pathogenesis NN cord-348746-yaf61cmx 253 8 of of IN cord-348746-yaf61cmx 253 9 FIP FIP NNP cord-348746-yaf61cmx 253 10 will will MD cord-348746-yaf61cmx 253 11 be be VB cord-348746-yaf61cmx 253 12 necessary necessary JJ cord-348746-yaf61cmx 253 13 to to TO cord-348746-yaf61cmx 253 14 offer offer VB cord-348746-yaf61cmx 253 15 better well JJR cord-348746-yaf61cmx 253 16 treatment treatment NN cord-348746-yaf61cmx 253 17 and and CC cord-348746-yaf61cmx 253 18 , , , cord-348746-yaf61cmx 253 19 ultimately ultimately RB cord-348746-yaf61cmx 253 20 , , , cord-348746-yaf61cmx 253 21 cure cure NN cord-348746-yaf61cmx 253 22 of of IN cord-348746-yaf61cmx 253 23 this this DT cord-348746-yaf61cmx 253 24 disease disease NN cord-348746-yaf61cmx 253 25 . . . cord-348746-yaf61cmx 254 1 The the DT cord-348746-yaf61cmx 254 2 inheritance inheritance NN cord-348746-yaf61cmx 254 3 of of IN cord-348746-yaf61cmx 254 4 susceptibility susceptibility NN cord-348746-yaf61cmx 254 5 to to IN cord-348746-yaf61cmx 254 6 feline feline JJ cord-348746-yaf61cmx 254 7 infectious infectious JJ cord-348746-yaf61cmx 254 8 peritonitis peritonitis NN cord-348746-yaf61cmx 254 9 in in IN cord-348746-yaf61cmx 254 10 purebred purebred JJ cord-348746-yaf61cmx 254 11 catteries catterie NNS cord-348746-yaf61cmx 255 1 Two two CD cord-348746-yaf61cmx 255 2 related related JJ cord-348746-yaf61cmx 255 3 strains strain NNS cord-348746-yaf61cmx 255 4 of of IN cord-348746-yaf61cmx 255 5 feline feline JJ cord-348746-yaf61cmx 255 6 infectious infectious JJ cord-348746-yaf61cmx 255 7 peritonitis peritonitis NN cord-348746-yaf61cmx 255 8 virus virus NN cord-348746-yaf61cmx 255 9 isolated isolate VBN cord-348746-yaf61cmx 255 10 from from IN cord-348746-yaf61cmx 255 11 immunocompromised immunocompromised JJ cord-348746-yaf61cmx 255 12 cats cat NNS cord-348746-yaf61cmx 255 13 infected infect VBN cord-348746-yaf61cmx 255 14 with with IN cord-348746-yaf61cmx 255 15 a a DT cord-348746-yaf61cmx 255 16 feline feline JJ cord-348746-yaf61cmx 255 17 enteric enteric JJ cord-348746-yaf61cmx 255 18 coronavirus coronavirus NN cord-348746-yaf61cmx 256 1 A a DT cord-348746-yaf61cmx 256 2 comparison comparison NN cord-348746-yaf61cmx 256 3 of of IN cord-348746-yaf61cmx 256 4 the the DT cord-348746-yaf61cmx 256 5 genomes genome NNS cord-348746-yaf61cmx 256 6 of of IN cord-348746-yaf61cmx 256 7 FECVs fecv NNS cord-348746-yaf61cmx 256 8 and and CC cord-348746-yaf61cmx 256 9 FIPVs fipv NNS cord-348746-yaf61cmx 256 10 and and CC cord-348746-yaf61cmx 256 11 what what WP cord-348746-yaf61cmx 256 12 they -PRON- PRP cord-348746-yaf61cmx 256 13 tell tell VBP cord-348746-yaf61cmx 256 14 us -PRON- PRP cord-348746-yaf61cmx 256 15 about about IN cord-348746-yaf61cmx 256 16 the the DT cord-348746-yaf61cmx 256 17 relationships relationship NNS cord-348746-yaf61cmx 256 18 between between IN cord-348746-yaf61cmx 256 19 feline feline JJ cord-348746-yaf61cmx 256 20 coronaviruses coronaviruse NNS cord-348746-yaf61cmx 256 21 and and CC cord-348746-yaf61cmx 256 22 their -PRON- PRP$ cord-348746-yaf61cmx 256 23 evolution evolution NN cord-348746-yaf61cmx 256 24 Feline feline JJ cord-348746-yaf61cmx 256 25 infectious infectious JJ cord-348746-yaf61cmx 256 26 peritonitis peritonitis NN cord-348746-yaf61cmx 256 27 viruses virus NNS cord-348746-yaf61cmx 256 28 arise arise VBP cord-348746-yaf61cmx 256 29 by by IN cord-348746-yaf61cmx 256 30 mutation mutation NN cord-348746-yaf61cmx 256 31 from from IN cord-348746-yaf61cmx 256 32 endemic endemic JJ cord-348746-yaf61cmx 256 33 feline feline JJ cord-348746-yaf61cmx 256 34 enteric enteric JJ cord-348746-yaf61cmx 256 35 coronaviruses coronaviruse NNS cord-348746-yaf61cmx 256 36 Feline feline JJ cord-348746-yaf61cmx 256 37 coronavirus coronavirus NN cord-348746-yaf61cmx 256 38 type type NN cord-348746-yaf61cmx 256 39 II ii CD cord-348746-yaf61cmx 256 40 strains strain VBZ cord-348746-yaf61cmx 256 41 79 79 CD cord-348746-yaf61cmx 256 42 - - HYPH cord-348746-yaf61cmx 256 43 1683 1683 CD cord-348746-yaf61cmx 256 44 and and CC cord-348746-yaf61cmx 256 45 79 79 CD cord-348746-yaf61cmx 256 46 - - SYM cord-348746-yaf61cmx 256 47 1146 1146 CD cord-348746-yaf61cmx 256 48 originate originate VBP cord-348746-yaf61cmx 256 49 from from IN cord-348746-yaf61cmx 256 50 a a DT cord-348746-yaf61cmx 256 51 double double JJ cord-348746-yaf61cmx 256 52 recombination recombination NN cord-348746-yaf61cmx 256 53 between between IN cord-348746-yaf61cmx 256 54 feline feline JJ cord-348746-yaf61cmx 256 55 coronavirus coronavirus NN cord-348746-yaf61cmx 256 56 type type NN cord-348746-yaf61cmx 256 57 I -PRON- PRP cord-348746-yaf61cmx 256 58 and and CC cord-348746-yaf61cmx 256 59 canine canine JJ cord-348746-yaf61cmx 256 60 coronavirus coronavirus NN cord-348746-yaf61cmx 257 1 The the DT cord-348746-yaf61cmx 257 2 molecular molecular JJ cord-348746-yaf61cmx 257 3 genetics genetic NNS cord-348746-yaf61cmx 257 4 of of IN cord-348746-yaf61cmx 257 5 feline feline JJ cord-348746-yaf61cmx 257 6 coronaviruses coronaviruse NNS cord-348746-yaf61cmx 257 7 : : : cord-348746-yaf61cmx 257 8 Comparative comparative JJ cord-348746-yaf61cmx 257 9 sequence sequence NN cord-348746-yaf61cmx 257 10 analysis analysis NN cord-348746-yaf61cmx 257 11 of of IN cord-348746-yaf61cmx 257 12 the the DT cord-348746-yaf61cmx 257 13 ORF7a/7b ORF7a/7b NNP cord-348746-yaf61cmx 257 14 transcription transcription NN cord-348746-yaf61cmx 257 15 unit unit NN cord-348746-yaf61cmx 257 16 of of IN cord-348746-yaf61cmx 257 17 different different JJ cord-348746-yaf61cmx 257 18 biotypes biotype NNS cord-348746-yaf61cmx 258 1 A a DT cord-348746-yaf61cmx 258 2 novel novel JJ cord-348746-yaf61cmx 258 3 glycoprotein glycoprotein NN cord-348746-yaf61cmx 258 4 of of IN cord-348746-yaf61cmx 258 5 feline feline JJ cord-348746-yaf61cmx 258 6 infectious infectious JJ cord-348746-yaf61cmx 258 7 peritonitis peritonitis NN cord-348746-yaf61cmx 258 8 coronavirus coronavirus NN cord-348746-yaf61cmx 258 9 contains contain VBZ cord-348746-yaf61cmx 258 10 a a DT cord-348746-yaf61cmx 258 11 KDEL KDEL NNP cord-348746-yaf61cmx 258 12 - - HYPH cord-348746-yaf61cmx 258 13 like like JJ cord-348746-yaf61cmx 258 14 endoplasmic endoplasmic NN cord-348746-yaf61cmx 258 15 reticulum reticulum NN cord-348746-yaf61cmx 258 16 retention retention NN cord-348746-yaf61cmx 258 17 signal signal NN cord-348746-yaf61cmx 258 18 Proteolytic proteolytic JJ cord-348746-yaf61cmx 258 19 cleavage cleavage NN cord-348746-yaf61cmx 258 20 of of IN cord-348746-yaf61cmx 258 21 the the DT cord-348746-yaf61cmx 258 22 E2 E2 NNP cord-348746-yaf61cmx 258 23 glycoprotein glycoprotein NN cord-348746-yaf61cmx 258 24 of of IN cord-348746-yaf61cmx 258 25 murine murine JJ cord-348746-yaf61cmx 258 26 coronavirus coronavirus NN cord-348746-yaf61cmx 258 27 : : : cord-348746-yaf61cmx 258 28 Activation activation NN cord-348746-yaf61cmx 258 29 of of IN cord-348746-yaf61cmx 258 30 cell cell NN cord-348746-yaf61cmx 258 31 - - HYPH cord-348746-yaf61cmx 258 32 fusing fuse VBG cord-348746-yaf61cmx 258 33 activity activity NN cord-348746-yaf61cmx 258 34 of of IN cord-348746-yaf61cmx 258 35 virions virion NNS cord-348746-yaf61cmx 258 36 by by IN cord-348746-yaf61cmx 258 37 trypsin trypsin NN cord-348746-yaf61cmx 258 38 and and CC cord-348746-yaf61cmx 258 39 separation separation NN cord-348746-yaf61cmx 258 40 of of IN cord-348746-yaf61cmx 258 41 two two CD cord-348746-yaf61cmx 258 42 different different JJ cord-348746-yaf61cmx 258 43 90 90 CD cord-348746-yaf61cmx 258 44 K k NN cord-348746-yaf61cmx 258 45 cleavage cleavage NN cord-348746-yaf61cmx 258 46 fragments fragment NNS cord-348746-yaf61cmx 258 47 Site site NN cord-348746-yaf61cmx 258 48 - - HYPH cord-348746-yaf61cmx 258 49 specific specific JJ cord-348746-yaf61cmx 258 50 alteration alteration NN cord-348746-yaf61cmx 258 51 of of IN cord-348746-yaf61cmx 258 52 murine murine JJ cord-348746-yaf61cmx 258 53 hepatitis hepatitis NN cord-348746-yaf61cmx 258 54 virus virus NN cord-348746-yaf61cmx 258 55 type type NN cord-348746-yaf61cmx 258 56 4 4 CD cord-348746-yaf61cmx 258 57 peplomer peplomer NN cord-348746-yaf61cmx 258 58 glycoprotein glycoprotein NN cord-348746-yaf61cmx 258 59 E2 E2 NNP cord-348746-yaf61cmx 258 60 results result NNS cord-348746-yaf61cmx 258 61 in in IN cord-348746-yaf61cmx 258 62 reduced reduce VBN cord-348746-yaf61cmx 258 63 neurovirulence neurovirulence NN cord-348746-yaf61cmx 258 64 Sequence sequence NN cord-348746-yaf61cmx 258 65 analysis analysis NN cord-348746-yaf61cmx 258 66 of of IN cord-348746-yaf61cmx 258 67 human human JJ cord-348746-yaf61cmx 258 68 coronavirus coronavirus NN cord-348746-yaf61cmx 258 69 229E 229e CD cord-348746-yaf61cmx 259 1 mRNAs mrnas CD cord-348746-yaf61cmx 259 2 4 4 CD cord-348746-yaf61cmx 259 3 and and CC cord-348746-yaf61cmx 259 4 5 5 CD cord-348746-yaf61cmx 259 5 : : : cord-348746-yaf61cmx 259 6 Evidence evidence NN cord-348746-yaf61cmx 259 7 for for IN cord-348746-yaf61cmx 259 8 polymorphism polymorphism NN cord-348746-yaf61cmx 259 9 and and CC cord-348746-yaf61cmx 259 10 homology homology NN cord-348746-yaf61cmx 259 11 with with IN cord-348746-yaf61cmx 259 12 myelin myelin JJ cord-348746-yaf61cmx 259 13 basic basic JJ cord-348746-yaf61cmx 259 14 protein protein NN cord-348746-yaf61cmx 259 15 Risk risk NN cord-348746-yaf61cmx 259 16 factors factor NNS cord-348746-yaf61cmx 259 17 for for IN cord-348746-yaf61cmx 259 18 feline feline JJ cord-348746-yaf61cmx 259 19 infectious infectious JJ cord-348746-yaf61cmx 259 20 peritonitis peritonitis NN cord-348746-yaf61cmx 259 21 among among IN cord-348746-yaf61cmx 259 22 cats cat NNS cord-348746-yaf61cmx 259 23 in in IN cord-348746-yaf61cmx 259 24 multiple multiple JJ cord-348746-yaf61cmx 259 25 - - HYPH cord-348746-yaf61cmx 259 26 cat cat NN cord-348746-yaf61cmx 259 27 environments environment NNS cord-348746-yaf61cmx 259 28 with with IN cord-348746-yaf61cmx 259 29 endemic endemic JJ cord-348746-yaf61cmx 259 30 feline feline JJ cord-348746-yaf61cmx 259 31 enteric enteric JJ cord-348746-yaf61cmx 259 32 coronavirus coronavirus NN cord-348746-yaf61cmx 259 33 Inflammations inflammation NNS cord-348746-yaf61cmx 259 34 of of IN cord-348746-yaf61cmx 259 35 the the DT cord-348746-yaf61cmx 259 36 nervous nervous JJ cord-348746-yaf61cmx 259 37 system system NN cord-348746-yaf61cmx 259 38 Feline feline JJ cord-348746-yaf61cmx 259 39 infectious infectious JJ cord-348746-yaf61cmx 259 40 peritonitis peritonitis NN cord-348746-yaf61cmx 259 41 : : : cord-348746-yaf61cmx 260 1 The the DT cord-348746-yaf61cmx 260 2 central central JJ cord-348746-yaf61cmx 260 3 nervous nervous JJ cord-348746-yaf61cmx 260 4 system system NN cord-348746-yaf61cmx 260 5 form form NN cord-348746-yaf61cmx 260 6 Diagnostic diagnostic JJ cord-348746-yaf61cmx 260 7 features feature NNS cord-348746-yaf61cmx 260 8 of of IN cord-348746-yaf61cmx 260 9 neurologic neurologic JJ cord-348746-yaf61cmx 260 10 feline feline JJ cord-348746-yaf61cmx 260 11 infectious infectious JJ cord-348746-yaf61cmx 260 12 peritonitis peritonitis NN cord-348746-yaf61cmx 260 13 Feline feline JJ cord-348746-yaf61cmx 260 14 infectious infectious JJ cord-348746-yaf61cmx 260 15 peritonitis peritonitis NN cord-348746-yaf61cmx 260 16 with with IN cord-348746-yaf61cmx 260 17 neurological neurological JJ cord-348746-yaf61cmx 260 18 involvement involvement NN cord-348746-yaf61cmx 260 19 : : : cord-348746-yaf61cmx 261 1 Clinical clinical JJ cord-348746-yaf61cmx 261 2 and and CC cord-348746-yaf61cmx 261 3 pathological pathological JJ cord-348746-yaf61cmx 261 4 findings finding NNS cord-348746-yaf61cmx 261 5 in in IN cord-348746-yaf61cmx 261 6 24 24 CD cord-348746-yaf61cmx 261 7 cats cat NNS cord-348746-yaf61cmx 261 8 Feline feline JJ cord-348746-yaf61cmx 261 9 infectious infectious JJ cord-348746-yaf61cmx 261 10 peritonitis peritonitis NN cord-348746-yaf61cmx 261 11 and and CC cord-348746-yaf61cmx 261 12 feline feline JJ cord-348746-yaf61cmx 261 13 enteric enteric JJ cord-348746-yaf61cmx 261 14 coronavirus coronavirus NN cord-348746-yaf61cmx 261 15 infections infection NNS cord-348746-yaf61cmx 261 16 . . . cord-348746-yaf61cmx 262 1 Part part NN cord-348746-yaf61cmx 262 2 2 2 CD cord-348746-yaf61cmx 262 3 : : : cord-348746-yaf61cmx 262 4 Feline feline JJ cord-348746-yaf61cmx 262 5 infectious infectious JJ cord-348746-yaf61cmx 262 6 peritonitis peritonitis NN cord-348746-yaf61cmx 262 7 Bartonella Bartonella NNP cord-348746-yaf61cmx 262 8 henselae henselae NN cord-348746-yaf61cmx 262 9 infection infection NN cord-348746-yaf61cmx 262 10 in in IN cord-348746-yaf61cmx 262 11 cats cat NNS cord-348746-yaf61cmx 262 12 : : : cord-348746-yaf61cmx 262 13 Evaluation evaluation NN cord-348746-yaf61cmx 262 14 during during IN cord-348746-yaf61cmx 262 15 primary primary JJ cord-348746-yaf61cmx 262 16 infection infection NN cord-348746-yaf61cmx 262 17 , , , cord-348746-yaf61cmx 262 18 treatment treatment NN cord-348746-yaf61cmx 262 19 , , , cord-348746-yaf61cmx 262 20 and and CC cord-348746-yaf61cmx 262 21 rechallenge rechallenge NN cord-348746-yaf61cmx 262 22 infection infection NN cord-348746-yaf61cmx 262 23 Feline feline JJ cord-348746-yaf61cmx 262 24 infectious infectious JJ cord-348746-yaf61cmx 262 25 peritonitis peritonitis NN cord-348746-yaf61cmx 262 26 : : : cord-348746-yaf61cmx 263 1 An an DT cord-348746-yaf61cmx 263 2 immune immune NN cord-348746-yaf61cmx 263 3 - - HYPH cord-348746-yaf61cmx 263 4 mediated mediate VBN cord-348746-yaf61cmx 263 5 coronaviral coronaviral JJ cord-348746-yaf61cmx 263 6 vasculitis vasculitis NN cord-348746-yaf61cmx 263 7 The the DT cord-348746-yaf61cmx 263 8 V5A13.1 V5A13.1 NNP cord-348746-yaf61cmx 263 9 envelope envelope NN cord-348746-yaf61cmx 263 10 glycoprotein glycoprotein NN cord-348746-yaf61cmx 263 11 deletion deletion NN cord-348746-yaf61cmx 263 12 mutant mutant NN cord-348746-yaf61cmx 263 13 of of IN cord-348746-yaf61cmx 263 14 mouse mouse NNP cord-348746-yaf61cmx 263 15 hepatitis hepatitis NNP cord-348746-yaf61cmx 263 16 virus virus NN cord-348746-yaf61cmx 264 1 type-4 type-4 NNP cord-348746-yaf61cmx 264 2 is be VBZ cord-348746-yaf61cmx 264 3 neuroattenuated neuroattenuate VBN cord-348746-yaf61cmx 264 4 by by IN cord-348746-yaf61cmx 264 5 its -PRON- PRP$ cord-348746-yaf61cmx 264 6 reduced reduce VBN cord-348746-yaf61cmx 264 7 rate rate NN cord-348746-yaf61cmx 264 8 of of IN cord-348746-yaf61cmx 264 9 spread spread NN cord-348746-yaf61cmx 264 10 in in IN cord-348746-yaf61cmx 264 11 the the DT cord-348746-yaf61cmx 264 12 central central JJ cord-348746-yaf61cmx 264 13 nervous nervous JJ cord-348746-yaf61cmx 264 14 system system NN cord-348746-yaf61cmx 264 15 Late late JJ cord-348746-yaf61cmx 264 16 onset onset NN cord-348746-yaf61cmx 264 17 , , , cord-348746-yaf61cmx 264 18 symptomatic symptomatic JJ cord-348746-yaf61cmx 264 19 , , , cord-348746-yaf61cmx 264 20 demyelinating demyelinate VBG cord-348746-yaf61cmx 264 21 encephalomyelitis encephalomyelitis NN cord-348746-yaf61cmx 264 22 in in IN cord-348746-yaf61cmx 264 23 mice mouse NNS cord-348746-yaf61cmx 264 24 infected infect VBN cord-348746-yaf61cmx 264 25 with with IN cord-348746-yaf61cmx 264 26 MHV MHV NNP cord-348746-yaf61cmx 264 27 - - HYPH cord-348746-yaf61cmx 264 28 JHM JHM NNP cord-348746-yaf61cmx 264 29 in in IN cord-348746-yaf61cmx 264 30 the the DT cord-348746-yaf61cmx 264 31 presence presence NN cord-348746-yaf61cmx 264 32 of of IN cord-348746-yaf61cmx 264 33 maternal maternal JJ cord-348746-yaf61cmx 264 34 antibody antibody NN cord-348746-yaf61cmx 264 35 Dissociation Dissociation NNP cord-348746-yaf61cmx 264 36 of of IN cord-348746-yaf61cmx 264 37 demyelination demyelination NN cord-348746-yaf61cmx 264 38 and and CC cord-348746-yaf61cmx 264 39 viral viral JJ cord-348746-yaf61cmx 264 40 clearance clearance NN cord-348746-yaf61cmx 264 41 in in IN cord-348746-yaf61cmx 264 42 congenitally congenitally RB cord-348746-yaf61cmx 264 43 immunodeficient immunodeficient JJ cord-348746-yaf61cmx 264 44 mice mouse NNS cord-348746-yaf61cmx 264 45 infected infect VBN cord-348746-yaf61cmx 264 46 with with IN cord-348746-yaf61cmx 264 47 murine murine JJ cord-348746-yaf61cmx 264 48 coronavirus coronavirus NN cord-348746-yaf61cmx 264 49 JHM JHM NNP cord-348746-yaf61cmx 264 50 Molecular molecular JJ cord-348746-yaf61cmx 264 51 determinants determinant NNS cord-348746-yaf61cmx 264 52 of of IN cord-348746-yaf61cmx 264 53 CNS CNS NNP cord-348746-yaf61cmx 264 54 virulence virulence NN cord-348746-yaf61cmx 264 55 of of IN cord-348746-yaf61cmx 264 56 MHV-4 MHV-4 NNP cord-348746-yaf61cmx 264 57 Experimental experimental JJ cord-348746-yaf61cmx 264 58 demyelination demyelination NN cord-348746-yaf61cmx 264 59 induced induce VBN cord-348746-yaf61cmx 264 60 by by IN cord-348746-yaf61cmx 264 61 coronavirus coronavirus NN cord-348746-yaf61cmx 264 62 JHM JHM NNP cord-348746-yaf61cmx 264 63 ( ( -LRB- cord-348746-yaf61cmx 264 64 MHV-4 MHV-4 NNP cord-348746-yaf61cmx 264 65 ) ) -RRB- cord-348746-yaf61cmx 264 66 : : : cord-348746-yaf61cmx 265 1 Molecular molecular JJ cord-348746-yaf61cmx 265 2 identification identification NN cord-348746-yaf61cmx 265 3 of of IN cord-348746-yaf61cmx 265 4 a a DT cord-348746-yaf61cmx 265 5 viral viral JJ cord-348746-yaf61cmx 265 6 determinant determinant NN cord-348746-yaf61cmx 265 7 of of IN cord-348746-yaf61cmx 265 8 paralytic paralytic JJ cord-348746-yaf61cmx 265 9 disease disease NN cord-348746-yaf61cmx 265 10 Cytokine cytokine NN cord-348746-yaf61cmx 265 11 induction induction NN cord-348746-yaf61cmx 265 12 during during IN cord-348746-yaf61cmx 265 13 T t NN cord-348746-yaf61cmx 265 14 - - HYPH cord-348746-yaf61cmx 265 15 cell cell NN cord-348746-yaf61cmx 265 16 - - HYPH cord-348746-yaf61cmx 265 17 mediated mediate VBN cord-348746-yaf61cmx 265 18 clearance clearance NN cord-348746-yaf61cmx 265 19 of of IN cord-348746-yaf61cmx 265 20 mouse mouse NN cord-348746-yaf61cmx 265 21 hepatitis hepatitis NN cord-348746-yaf61cmx 265 22 virus virus NN cord-348746-yaf61cmx 265 23 from from IN cord-348746-yaf61cmx 265 24 neurons neuron NNS cord-348746-yaf61cmx 265 25 in in IN cord-348746-yaf61cmx 265 26 vivo vivo NNP cord-348746-yaf61cmx 265 27 Cellular cellular JJ cord-348746-yaf61cmx 265 28 composition composition NN cord-348746-yaf61cmx 265 29 , , , cord-348746-yaf61cmx 265 30 coronavirus coronavirus NN cord-348746-yaf61cmx 265 31 antigen antigen NN cord-348746-yaf61cmx 265 32 expression expression NN cord-348746-yaf61cmx 265 33 and and CC cord-348746-yaf61cmx 265 34 production production NN cord-348746-yaf61cmx 265 35 of of IN cord-348746-yaf61cmx 265 36 specific specific JJ cord-348746-yaf61cmx 265 37 antibodies antibody NNS cord-348746-yaf61cmx 265 38 in in IN cord-348746-yaf61cmx 265 39 lesions lesion NNS cord-348746-yaf61cmx 265 40 in in IN cord-348746-yaf61cmx 265 41 feline feline JJ cord-348746-yaf61cmx 265 42 infectious infectious JJ cord-348746-yaf61cmx 265 43 peritonitis peritonitis NN cord-348746-yaf61cmx 265 44 Meningoencephalitis Meningoencephalitis NNP cord-348746-yaf61cmx 265 45 and and CC cord-348746-yaf61cmx 265 46 panophthalmitis panophthalmitis NNP cord-348746-yaf61cmx 265 47 in in IN cord-348746-yaf61cmx 265 48 feline feline JJ cord-348746-yaf61cmx 265 49 infectious infectious JJ cord-348746-yaf61cmx 265 50 peritonitis peritonitis NN cord-348746-yaf61cmx 265 51 Hydrocephalus hydrocephalus NN cord-348746-yaf61cmx 265 52 associated associate VBN cord-348746-yaf61cmx 265 53 with with IN cord-348746-yaf61cmx 265 54 the the DT cord-348746-yaf61cmx 265 55 noneffusive noneffusive JJ cord-348746-yaf61cmx 265 56 form form NN cord-348746-yaf61cmx 265 57 of of IN cord-348746-yaf61cmx 265 58 feline feline JJ cord-348746-yaf61cmx 265 59 infectious infectious JJ cord-348746-yaf61cmx 265 60 peritonitis peritonitis NN cord-348746-yaf61cmx 265 61 Feline feline JJ cord-348746-yaf61cmx 265 62 infectious infectious JJ cord-348746-yaf61cmx 265 63 peritonitis peritonitis NN cord-348746-yaf61cmx 265 64 with with IN cord-348746-yaf61cmx 265 65 spinal spinal JJ cord-348746-yaf61cmx 265 66 cord cord NN cord-348746-yaf61cmx 265 67 involvement involvement NN cord-348746-yaf61cmx 265 68 in in IN cord-348746-yaf61cmx 265 69 two two CD cord-348746-yaf61cmx 265 70 cats cat NNS cord-348746-yaf61cmx 266 1 Feline feline JJ cord-348746-yaf61cmx 266 2 infectious infectious JJ cord-348746-yaf61cmx 266 3 peritonitis peritonitis NN cord-348746-yaf61cmx 266 4 Acquired acquire VBD cord-348746-yaf61cmx 266 5 hydrocephalus hydrocephalus NN cord-348746-yaf61cmx 266 6 and and CC cord-348746-yaf61cmx 266 7 hydromyelia hydromyelia NN cord-348746-yaf61cmx 266 8 in in IN cord-348746-yaf61cmx 266 9 a a DT cord-348746-yaf61cmx 266 10 cat cat NN cord-348746-yaf61cmx 266 11 with with IN cord-348746-yaf61cmx 266 12 feline feline JJ cord-348746-yaf61cmx 266 13 infectious infectious JJ cord-348746-yaf61cmx 266 14 peritonitis peritonitis NN cord-348746-yaf61cmx 266 15 : : : cord-348746-yaf61cmx 267 1 A a DT cord-348746-yaf61cmx 267 2 case case NN cord-348746-yaf61cmx 267 3 report report NN cord-348746-yaf61cmx 267 4 and and CC cord-348746-yaf61cmx 267 5 brief brief JJ cord-348746-yaf61cmx 267 6 review review NN cord-348746-yaf61cmx 267 7 Mechanism mechanism NN cord-348746-yaf61cmx 267 8 of of IN cord-348746-yaf61cmx 267 9 demyelination demyelination NN cord-348746-yaf61cmx 267 10 in in IN cord-348746-yaf61cmx 267 11 JHM JHM NNP cord-348746-yaf61cmx 267 12 virus virus NN cord-348746-yaf61cmx 267 13 encephalomyelitis encephalomyelitis NN cord-348746-yaf61cmx 267 14 . . . cord-348746-yaf61cmx 268 1 Electron electron NN cord-348746-yaf61cmx 268 2 microscopic microscopic JJ cord-348746-yaf61cmx 268 3 studies study NNS cord-348746-yaf61cmx 269 1 The the DT cord-348746-yaf61cmx 269 2 protective protective JJ cord-348746-yaf61cmx 269 3 role role NN cord-348746-yaf61cmx 269 4 of of IN cord-348746-yaf61cmx 269 5 cytotoxic cytotoxic JJ cord-348746-yaf61cmx 269 6 T t NN cord-348746-yaf61cmx 269 7 cells cell NNS cord-348746-yaf61cmx 269 8 and and CC cord-348746-yaf61cmx 269 9 interferon interferon NN cord-348746-yaf61cmx 269 10 against against IN cord-348746-yaf61cmx 269 11 coronavirus coronavirus NN cord-348746-yaf61cmx 269 12 invasion invasion NN cord-348746-yaf61cmx 269 13 of of IN cord-348746-yaf61cmx 269 14 the the DT cord-348746-yaf61cmx 269 15 brain brain NN cord-348746-yaf61cmx 270 1 In in IN cord-348746-yaf61cmx 270 2 vitro vitro FW cord-348746-yaf61cmx 270 3 interaction interaction NN cord-348746-yaf61cmx 270 4 of of IN cord-348746-yaf61cmx 270 5 coronaviruses coronaviruse NNS cord-348746-yaf61cmx 270 6 with with IN cord-348746-yaf61cmx 270 7 primate primate JJ cord-348746-yaf61cmx 270 8 and and CC cord-348746-yaf61cmx 270 9 human human JJ cord-348746-yaf61cmx 270 10 brain brain NN cord-348746-yaf61cmx 270 11 microvascular microvascular NN cord-348746-yaf61cmx 270 12 endothelial endothelial JJ cord-348746-yaf61cmx 270 13 cells cell NNS cord-348746-yaf61cmx 270 14 Pathogenesis Pathogenesis NNP cord-348746-yaf61cmx 270 15 of of IN cord-348746-yaf61cmx 270 16 demyelination demyelination NN cord-348746-yaf61cmx 270 17 induced induce VBN cord-348746-yaf61cmx 270 18 by by IN cord-348746-yaf61cmx 270 19 a a DT cord-348746-yaf61cmx 270 20 mouse mouse NN cord-348746-yaf61cmx 270 21 hepatitis hepatitis NN cord-348746-yaf61cmx 270 22 Immunohistological Immunohistological NNP cord-348746-yaf61cmx 270 23 demonstration demonstration NN cord-348746-yaf61cmx 270 24 of of IN cord-348746-yaf61cmx 270 25 feline feline JJ cord-348746-yaf61cmx 270 26 infectious infectious JJ cord-348746-yaf61cmx 270 27 peritonitis peritonitis NN cord-348746-yaf61cmx 270 28 virus virus NN cord-348746-yaf61cmx 270 29 antigen antigen NN cord-348746-yaf61cmx 270 30 in in IN cord-348746-yaf61cmx 270 31 paraffin paraffin NN cord-348746-yaf61cmx 270 32 - - HYPH cord-348746-yaf61cmx 270 33 embedded embed VBN cord-348746-yaf61cmx 270 34 tissues tissue NNS cord-348746-yaf61cmx 270 35 using use VBG cord-348746-yaf61cmx 270 36 feline feline JJ cord-348746-yaf61cmx 270 37 ascites ascite NNS cord-348746-yaf61cmx 270 38 or or CC cord-348746-yaf61cmx 270 39 murine murine JJ cord-348746-yaf61cmx 270 40 monoclonal monoclonal JJ cord-348746-yaf61cmx 270 41 antibodies antibody NNS cord-348746-yaf61cmx 271 1 Some some DT cord-348746-yaf61cmx 271 2 aspects aspect NNS cord-348746-yaf61cmx 271 3 of of IN cord-348746-yaf61cmx 271 4 humoral humoral JJ cord-348746-yaf61cmx 271 5 and and CC cord-348746-yaf61cmx 271 6 cellular cellular JJ cord-348746-yaf61cmx 271 7 immunity immunity NN cord-348746-yaf61cmx 271 8 in in IN cord-348746-yaf61cmx 271 9 naturally naturally RB cord-348746-yaf61cmx 271 10 occurring occur VBG cord-348746-yaf61cmx 271 11 feline feline JJ cord-348746-yaf61cmx 271 12 infectious infectious JJ cord-348746-yaf61cmx 271 13 peritonitis peritonitis NN cord-348746-yaf61cmx 271 14 The the DT cord-348746-yaf61cmx 271 15 olfactory olfactory JJ cord-348746-yaf61cmx 271 16 nerve nerve NN cord-348746-yaf61cmx 271 17 and and CC cord-348746-yaf61cmx 271 18 not not RB cord-348746-yaf61cmx 271 19 the the DT cord-348746-yaf61cmx 271 20 trigeminal trigeminal JJ cord-348746-yaf61cmx 271 21 nerve nerve NN cord-348746-yaf61cmx 271 22 is be VBZ cord-348746-yaf61cmx 271 23 the the DT cord-348746-yaf61cmx 271 24 major major JJ cord-348746-yaf61cmx 271 25 site site NN cord-348746-yaf61cmx 271 26 of of IN cord-348746-yaf61cmx 271 27 CNS CNS NNP cord-348746-yaf61cmx 271 28 entry entry NN cord-348746-yaf61cmx 271 29 for for IN cord-348746-yaf61cmx 271 30 mouse mouse NN cord-348746-yaf61cmx 271 31 hepatitis hepatitis NNP cord-348746-yaf61cmx 271 32 virus virus NN cord-348746-yaf61cmx 271 33 , , , cord-348746-yaf61cmx 271 34 strain strain VB cord-348746-yaf61cmx 271 35 JHM JHM NNP cord-348746-yaf61cmx 271 36 Viremic Viremic NNP cord-348746-yaf61cmx 271 37 dissemination dissemination NN cord-348746-yaf61cmx 271 38 of of IN cord-348746-yaf61cmx 271 39 mouse mouse NN cord-348746-yaf61cmx 271 40 hepatitis hepatitis NNP cord-348746-yaf61cmx 271 41 virus virus NN cord-348746-yaf61cmx 271 42 - - : cord-348746-yaf61cmx 271 43 JHM JHM NNP cord-348746-yaf61cmx 271 44 following follow VBG cord-348746-yaf61cmx 271 45 intranasal intranasal NN cord-348746-yaf61cmx 271 46 inoculation inoculation NN cord-348746-yaf61cmx 271 47 of of IN cord-348746-yaf61cmx 271 48 mice mouse NNS cord-348746-yaf61cmx 271 49 Entry Entry NNP cord-348746-yaf61cmx 271 50 of of IN cord-348746-yaf61cmx 271 51 coronavirus coronavirus NN cord-348746-yaf61cmx 271 52 into into IN cord-348746-yaf61cmx 271 53 primate primate JJ cord-348746-yaf61cmx 271 54 CNS cns NN cord-348746-yaf61cmx 271 55 following follow VBG cord-348746-yaf61cmx 271 56 peripheral peripheral JJ cord-348746-yaf61cmx 271 57 infection infection NN cord-348746-yaf61cmx 271 58 Involvement Involvement NNP cord-348746-yaf61cmx 271 59 of of IN cord-348746-yaf61cmx 271 60 aminopeptidase aminopeptidase NN cord-348746-yaf61cmx 271 61 N N NNP cord-348746-yaf61cmx 271 62 ( ( -LRB- cord-348746-yaf61cmx 271 63 CD13 CD13 NNP cord-348746-yaf61cmx 271 64 ) ) -RRB- cord-348746-yaf61cmx 271 65 in in IN cord-348746-yaf61cmx 271 66 infection infection NN cord-348746-yaf61cmx 271 67 of of IN cord-348746-yaf61cmx 271 68 human human JJ cord-348746-yaf61cmx 271 69 neural neural JJ cord-348746-yaf61cmx 271 70 cells cell NNS cord-348746-yaf61cmx 271 71 by by IN cord-348746-yaf61cmx 271 72 human human JJ cord-348746-yaf61cmx 271 73 coronavirus coronavirus NN cord-348746-yaf61cmx 271 74 229E 229e CD cord-348746-yaf61cmx 271 75 Replication replication NN cord-348746-yaf61cmx 271 76 of of IN cord-348746-yaf61cmx 271 77 human human JJ cord-348746-yaf61cmx 271 78 respiratory respiratory JJ cord-348746-yaf61cmx 271 79 coronavirus coronavirus NN cord-348746-yaf61cmx 272 1 strain strain NN cord-348746-yaf61cmx 272 2 229E 229e CD cord-348746-yaf61cmx 272 3 in in IN cord-348746-yaf61cmx 272 4 human human JJ cord-348746-yaf61cmx 272 5 macrophages macrophage NNS cord-348746-yaf61cmx 272 6 Characterization characterization NN cord-348746-yaf61cmx 272 7 of of IN cord-348746-yaf61cmx 272 8 a a DT cord-348746-yaf61cmx 272 9 variant variant JJ cord-348746-yaf61cmx 272 10 virus virus NN cord-348746-yaf61cmx 272 11 selected select VBN cord-348746-yaf61cmx 272 12 in in IN cord-348746-yaf61cmx 272 13 rat rat NN cord-348746-yaf61cmx 272 14 brains brain NNS cord-348746-yaf61cmx 272 15 after after IN cord-348746-yaf61cmx 272 16 infection infection NN cord-348746-yaf61cmx 272 17 by by IN cord-348746-yaf61cmx 272 18 coronavirus coronavirus NN cord-348746-yaf61cmx 272 19 mouse mouse NN cord-348746-yaf61cmx 272 20 hepatitis hepatitis NN cord-348746-yaf61cmx 272 21 virus virus NN cord-348746-yaf61cmx 272 22 JHM JHM NNP cord-348746-yaf61cmx 272 23 Spread Spread NNP cord-348746-yaf61cmx 272 24 of of IN cord-348746-yaf61cmx 272 25 a a DT cord-348746-yaf61cmx 272 26 neurotropic neurotropic JJ cord-348746-yaf61cmx 272 27 coronavirus coronavirus NN cord-348746-yaf61cmx 272 28 to to IN cord-348746-yaf61cmx 272 29 spinal spinal JJ cord-348746-yaf61cmx 272 30 cord cord NN cord-348746-yaf61cmx 272 31 white white JJ cord-348746-yaf61cmx 272 32 matter matter NN cord-348746-yaf61cmx 272 33 via via IN cord-348746-yaf61cmx 272 34 neurons neuron NNS cord-348746-yaf61cmx 272 35 and and CC cord-348746-yaf61cmx 272 36 astrocytes astrocyte NNS cord-348746-yaf61cmx 272 37 Afferent Afferent NNP cord-348746-yaf61cmx 272 38 and and CC cord-348746-yaf61cmx 272 39 efferent efferent JJ cord-348746-yaf61cmx 272 40 arms arm NNS cord-348746-yaf61cmx 272 41 of of IN cord-348746-yaf61cmx 272 42 the the DT cord-348746-yaf61cmx 272 43 humoral humoral JJ cord-348746-yaf61cmx 272 44 immune immune JJ cord-348746-yaf61cmx 272 45 response response NN cord-348746-yaf61cmx 272 46 to to IN cord-348746-yaf61cmx 272 47 CSF CSF NNP cord-348746-yaf61cmx 272 48 - - HYPH cord-348746-yaf61cmx 272 49 administered administer VBN cord-348746-yaf61cmx 272 50 albumins albumin NNS cord-348746-yaf61cmx 272 51 in in IN cord-348746-yaf61cmx 272 52 a a DT cord-348746-yaf61cmx 272 53 rat rat NN cord-348746-yaf61cmx 272 54 model model NN cord-348746-yaf61cmx 272 55 with with IN cord-348746-yaf61cmx 272 56 normal normal JJ cord-348746-yaf61cmx 272 57 blood blood NN cord-348746-yaf61cmx 272 58 - - HYPH cord-348746-yaf61cmx 272 59 brain brain NN cord-348746-yaf61cmx 272 60 barrier barrier NN cord-348746-yaf61cmx 272 61 permeability permeability NN cord-348746-yaf61cmx 272 62 T t NN cord-348746-yaf61cmx 272 63 - - HYPH cord-348746-yaf61cmx 272 64 lymphocyte lymphocyte NN cord-348746-yaf61cmx 272 65 entry entry NN cord-348746-yaf61cmx 272 66 into into IN cord-348746-yaf61cmx 272 67 the the DT cord-348746-yaf61cmx 272 68 central central JJ cord-348746-yaf61cmx 272 69 nervous nervous JJ cord-348746-yaf61cmx 272 70 system system NN cord-348746-yaf61cmx 272 71 Pathogenesis Pathogenesis NNP cord-348746-yaf61cmx 272 72 of of IN cord-348746-yaf61cmx 272 73 feline feline JJ cord-348746-yaf61cmx 272 74 infectious infectious JJ cord-348746-yaf61cmx 272 75 peritonitis peritonitis NN cord-348746-yaf61cmx 272 76 : : : cord-348746-yaf61cmx 272 77 Pathologic pathologic JJ cord-348746-yaf61cmx 272 78 changes change NNS cord-348746-yaf61cmx 272 79 and and CC cord-348746-yaf61cmx 272 80 immunofluorescence immunofluorescence NN cord-348746-yaf61cmx 272 81 Jacobse Jacobse NNP cord-348746-yaf61cmx 272 82 - - HYPH cord-348746-yaf61cmx 272 83 Geels Geels NNP cord-348746-yaf61cmx 273 1 HE HE NNP cord-348746-yaf61cmx 273 2 , , , cord-348746-yaf61cmx 273 3 Daha Daha NNP cord-348746-yaf61cmx 273 4 MR MR NNP cord-348746-yaf61cmx 273 5 , , , cord-348746-yaf61cmx 273 6 Horzinek Horzinek NNP cord-348746-yaf61cmx 273 7 MC MC NNP cord-348746-yaf61cmx 273 8 . . . cord-348746-yaf61cmx 274 1 Isolation isolation NN cord-348746-yaf61cmx 274 2 and and CC cord-348746-yaf61cmx 274 3 characterization characterization NN cord-348746-yaf61cmx 274 4 of of IN cord-348746-yaf61cmx 274 5 feline feline JJ cord-348746-yaf61cmx 274 6 C3 c3 NN cord-348746-yaf61cmx 274 7 and and CC cord-348746-yaf61cmx 274 8 evidence evidence NN cord-348746-yaf61cmx 274 9 for for IN cord-348746-yaf61cmx 274 10 the the DT cord-348746-yaf61cmx 274 11 immune immune JJ cord-348746-yaf61cmx 274 12 complex complex JJ cord-348746-yaf61cmx 274 13 pathogenesis pathogenesis NN cord-348746-yaf61cmx 274 14 of of IN cord-348746-yaf61cmx 274 15 feline feline JJ cord-348746-yaf61cmx 274 16 infectious infectious JJ cord-348746-yaf61cmx 274 17 peritonitis peritonitis NN cord-348746-yaf61cmx 274 18 Pathogenesis Pathogenesis NNP cord-348746-yaf61cmx 274 19 of of IN cord-348746-yaf61cmx 274 20 feline feline JJ cord-348746-yaf61cmx 274 21 infectious infectious JJ cord-348746-yaf61cmx 274 22 peritonitis peritonitis NN cord-348746-yaf61cmx 274 23 : : : cord-348746-yaf61cmx 274 24 Nature nature NN cord-348746-yaf61cmx 274 25 and and CC cord-348746-yaf61cmx 274 26 development development NN cord-348746-yaf61cmx 274 27 of of IN cord-348746-yaf61cmx 274 28 viremia viremia NN cord-348746-yaf61cmx 274 29 Early early JJ cord-348746-yaf61cmx 274 30 death death NN cord-348746-yaf61cmx 274 31 after after IN cord-348746-yaf61cmx 274 32 feline feline JJ cord-348746-yaf61cmx 274 33 infectious infectious JJ cord-348746-yaf61cmx 274 34 peritonitis peritonitis NN cord-348746-yaf61cmx 274 35 virus virus NN cord-348746-yaf61cmx 274 36 challenge challenge NN cord-348746-yaf61cmx 274 37 due due JJ cord-348746-yaf61cmx 274 38 to to IN cord-348746-yaf61cmx 274 39 recombinant recombinant JJ cord-348746-yaf61cmx 274 40 vaccinia vaccinia NN cord-348746-yaf61cmx 274 41 virus virus NN cord-348746-yaf61cmx 274 42 immunization immunization NN cord-348746-yaf61cmx 274 43 A a DT cord-348746-yaf61cmx 274 44 study study NN cord-348746-yaf61cmx 274 45 on on IN cord-348746-yaf61cmx 274 46 the the DT cord-348746-yaf61cmx 274 47 mechanism mechanism NN cord-348746-yaf61cmx 274 48 of of IN cord-348746-yaf61cmx 274 49 antibody antibody NN cord-348746-yaf61cmx 274 50 - - HYPH cord-348746-yaf61cmx 274 51 dependent dependent JJ cord-348746-yaf61cmx 274 52 enhancement enhancement NN cord-348746-yaf61cmx 274 53 of of IN cord-348746-yaf61cmx 274 54 feline feline JJ cord-348746-yaf61cmx 274 55 infectious infectious JJ cord-348746-yaf61cmx 274 56 peritonitis peritonitis NN cord-348746-yaf61cmx 274 57 virus virus NN cord-348746-yaf61cmx 274 58 infection infection NN cord-348746-yaf61cmx 274 59 in in IN cord-348746-yaf61cmx 274 60 feline feline JJ cord-348746-yaf61cmx 274 61 macrophages macrophage NNS cord-348746-yaf61cmx 274 62 by by IN cord-348746-yaf61cmx 274 63 monoclonal monoclonal JJ cord-348746-yaf61cmx 274 64 antibodies antibody NNS cord-348746-yaf61cmx 274 65 Monoclonal monoclonal JJ cord-348746-yaf61cmx 274 66 antibodies antibody NNS cord-348746-yaf61cmx 274 67 to to IN cord-348746-yaf61cmx 274 68 the the DT cord-348746-yaf61cmx 274 69 spike spike NN cord-348746-yaf61cmx 274 70 protein protein NN cord-348746-yaf61cmx 274 71 of of IN cord-348746-yaf61cmx 274 72 feline feline JJ cord-348746-yaf61cmx 274 73 infectious infectious JJ cord-348746-yaf61cmx 274 74 peritonitis peritonitis NN cord-348746-yaf61cmx 274 75 virus virus NN cord-348746-yaf61cmx 274 76 mediate mediate VB cord-348746-yaf61cmx 274 77 antibody antibody NN cord-348746-yaf61cmx 274 78 - - HYPH cord-348746-yaf61cmx 274 79 dependent dependent JJ cord-348746-yaf61cmx 274 80 enhancement enhancement NN cord-348746-yaf61cmx 274 81 of of IN cord-348746-yaf61cmx 274 82 infection infection NN cord-348746-yaf61cmx 274 83 of of IN cord-348746-yaf61cmx 274 84 feline feline JJ cord-348746-yaf61cmx 274 85 macrophages macrophage NNS cord-348746-yaf61cmx 274 86 Monoclonal Monoclonal NNP cord-348746-yaf61cmx 274 87 antibody antibody NN cord-348746-yaf61cmx 274 88 analysis analysis NN cord-348746-yaf61cmx 274 89 of of IN cord-348746-yaf61cmx 274 90 neutralization neutralization NN cord-348746-yaf61cmx 274 91 and and CC cord-348746-yaf61cmx 274 92 antibody antibody NN cord-348746-yaf61cmx 274 93 - - HYPH cord-348746-yaf61cmx 274 94 dependent dependent JJ cord-348746-yaf61cmx 274 95 enhancement enhancement NN cord-348746-yaf61cmx 274 96 of of IN cord-348746-yaf61cmx 274 97 feline feline JJ cord-348746-yaf61cmx 274 98 infectious infectious JJ cord-348746-yaf61cmx 274 99 peritonitis peritonitis NN cord-348746-yaf61cmx 274 100 virus virus NN cord-348746-yaf61cmx 274 101 Cytokine cytokine NN cord-348746-yaf61cmx 274 102 expression expression NN cord-348746-yaf61cmx 274 103 in in IN cord-348746-yaf61cmx 274 104 feline feline JJ cord-348746-yaf61cmx 274 105 lymphoid lymphoid JJ cord-348746-yaf61cmx 274 106 tissue tissue NN cord-348746-yaf61cmx 274 107 in in IN cord-348746-yaf61cmx 274 108 health health NN cord-348746-yaf61cmx 274 109 and and CC cord-348746-yaf61cmx 274 110 disease disease NN cord-348746-yaf61cmx 274 111 Antibody Antibody NNP cord-348746-yaf61cmx 274 112 and and CC cord-348746-yaf61cmx 274 113 cytokine cytokine NN cord-348746-yaf61cmx 274 114 responses response NNS cord-348746-yaf61cmx 274 115 in in IN cord-348746-yaf61cmx 274 116 kittens kitten NNS cord-348746-yaf61cmx 274 117 during during IN cord-348746-yaf61cmx 274 118 the the DT cord-348746-yaf61cmx 274 119 development development NN cord-348746-yaf61cmx 274 120 of of IN cord-348746-yaf61cmx 274 121 feline feline JJ cord-348746-yaf61cmx 274 122 infectious infectious JJ cord-348746-yaf61cmx 274 123 peritonitis peritonitis NN cord-348746-yaf61cmx 274 124 ( ( -LRB- cord-348746-yaf61cmx 274 125 FIP fip NN cord-348746-yaf61cmx 274 126 ) ) -RRB- cord-348746-yaf61cmx 275 1 Interleukin interleukin NN cord-348746-yaf61cmx 275 2 1 1 CD cord-348746-yaf61cmx 275 3 alpha alpha NN cord-348746-yaf61cmx 275 4 mRNA mrna NN cord-348746-yaf61cmx 275 5 - - HYPH cord-348746-yaf61cmx 275 6 expressing express VBG cord-348746-yaf61cmx 275 7 cells cell NNS cord-348746-yaf61cmx 275 8 on on IN cord-348746-yaf61cmx 275 9 the the DT cord-348746-yaf61cmx 275 10 local local JJ cord-348746-yaf61cmx 275 11 inflammatory inflammatory JJ cord-348746-yaf61cmx 275 12 response response NN cord-348746-yaf61cmx 275 13 in in IN cord-348746-yaf61cmx 275 14 feline feline JJ cord-348746-yaf61cmx 275 15 infectious infectious JJ cord-348746-yaf61cmx 275 16 peritonitis peritonitis NN cord-348746-yaf61cmx 275 17 Exposure exposure NN cord-348746-yaf61cmx 275 18 of of IN cord-348746-yaf61cmx 275 19 tumor tumor NN cord-348746-yaf61cmx 275 20 necrosis necrosis NN cord-348746-yaf61cmx 275 21 factor factor NN cord-348746-yaf61cmx 275 22 - - HYPH cord-348746-yaf61cmx 275 23 alpha alpha NN cord-348746-yaf61cmx 275 24 to to IN cord-348746-yaf61cmx 275 25 luminal luminal JJ cord-348746-yaf61cmx 275 26 membrane membrane NN cord-348746-yaf61cmx 275 27 of of IN cord-348746-yaf61cmx 275 28 bovine bovine JJ cord-348746-yaf61cmx 275 29 brain brain NN cord-348746-yaf61cmx 275 30 capillary capillary NN cord-348746-yaf61cmx 275 31 endothelial endothelial JJ cord-348746-yaf61cmx 275 32 cells cell NNS cord-348746-yaf61cmx 275 33 cocultured coculture VBN cord-348746-yaf61cmx 275 34 with with IN cord-348746-yaf61cmx 275 35 astrocytes astrocyte NNS cord-348746-yaf61cmx 275 36 induces induce VBZ cord-348746-yaf61cmx 275 37 a a DT cord-348746-yaf61cmx 275 38 delayed delayed JJ cord-348746-yaf61cmx 275 39 increase increase NN cord-348746-yaf61cmx 275 40 of of IN cord-348746-yaf61cmx 275 41 permeability permeability NN cord-348746-yaf61cmx 275 42 and and CC cord-348746-yaf61cmx 275 43 cytoplasmic cytoplasmic JJ cord-348746-yaf61cmx 275 44 stress stress NN cord-348746-yaf61cmx 275 45 fiber fiber NN cord-348746-yaf61cmx 275 46 formation formation NN cord-348746-yaf61cmx 275 47 of of IN cord-348746-yaf61cmx 275 48 actin actin JJ cord-348746-yaf61cmx 275 49 Effects effect NNS cord-348746-yaf61cmx 275 50 of of IN cord-348746-yaf61cmx 275 51 tumor tumor NN cord-348746-yaf61cmx 275 52 necrosis necrosis NN cord-348746-yaf61cmx 275 53 factor factor NN cord-348746-yaf61cmx 275 54 - - HYPH cord-348746-yaf61cmx 275 55 alpha alpha NN cord-348746-yaf61cmx 275 56 and and CC cord-348746-yaf61cmx 275 57 interleukin-6 interleukin-6 RB cord-348746-yaf61cmx 275 58 on on IN cord-348746-yaf61cmx 275 59 fluid fluid JJ cord-348746-yaf61cmx 275 60 - - HYPH cord-348746-yaf61cmx 275 61 phase phase NN cord-348746-yaf61cmx 275 62 permeability permeability NN cord-348746-yaf61cmx 275 63 and and CC cord-348746-yaf61cmx 275 64 ammonia ammonia NN cord-348746-yaf61cmx 275 65 diffusion diffusion NN cord-348746-yaf61cmx 275 66 in in IN cord-348746-yaf61cmx 275 67 CNS CNS NNP cord-348746-yaf61cmx 275 68 - - HYPH cord-348746-yaf61cmx 275 69 derived derive VBN cord-348746-yaf61cmx 275 70 endothelial endothelial JJ cord-348746-yaf61cmx 275 71 cells cell NNS cord-348746-yaf61cmx 276 1 In in IN cord-348746-yaf61cmx 276 2 vivo vivo NN cord-348746-yaf61cmx 276 3 effects effect NNS cord-348746-yaf61cmx 276 4 of of IN cord-348746-yaf61cmx 276 5 coronavirus coronavirus NN cord-348746-yaf61cmx 276 6 - - HYPH cord-348746-yaf61cmx 276 7 specific specific JJ cord-348746-yaf61cmx 276 8 T t NN cord-348746-yaf61cmx 276 9 cell cell NN cord-348746-yaf61cmx 276 10 clones clone NNS cord-348746-yaf61cmx 276 11 : : : cord-348746-yaf61cmx 276 12 DTH DTH NNP cord-348746-yaf61cmx 276 13 inducer inducer NN cord-348746-yaf61cmx 276 14 cells cell NNS cord-348746-yaf61cmx 276 15 prevent prevent VBP cord-348746-yaf61cmx 276 16 a a DT cord-348746-yaf61cmx 276 17 lethal lethal JJ cord-348746-yaf61cmx 276 18 infection infection NN cord-348746-yaf61cmx 276 19 but but CC cord-348746-yaf61cmx 276 20 do do VBP cord-348746-yaf61cmx 276 21 not not RB cord-348746-yaf61cmx 276 22 inhibit inhibit VB cord-348746-yaf61cmx 276 23 virus virus NN cord-348746-yaf61cmx 276 24 replication replication NN cord-348746-yaf61cmx 276 25 Monoclonal monoclonal JJ cord-348746-yaf61cmx 276 26 antibodies antibody NNS cord-348746-yaf61cmx 276 27 to to IN cord-348746-yaf61cmx 276 28 the the DT cord-348746-yaf61cmx 276 29 matrix matrix NN cord-348746-yaf61cmx 276 30 ( ( -LRB- cord-348746-yaf61cmx 276 31 E1 E1 NNP cord-348746-yaf61cmx 276 32 ) ) -RRB- cord-348746-yaf61cmx 276 33 glycoprotein glycoprotein NN cord-348746-yaf61cmx 276 34 of of IN cord-348746-yaf61cmx 276 35 mouse mouse NNP cord-348746-yaf61cmx 276 36 hepatitis hepatitis NNP cord-348746-yaf61cmx 276 37 virus virus NN cord-348746-yaf61cmx 276 38 protect protect VBP cord-348746-yaf61cmx 276 39 mice mouse NNS cord-348746-yaf61cmx 276 40 from from IN cord-348746-yaf61cmx 276 41 encephalitis encephalitis JJ cord-348746-yaf61cmx 276 42 Demyelination Demyelination NNP cord-348746-yaf61cmx 276 43 induced induce VBN cord-348746-yaf61cmx 276 44 by by IN cord-348746-yaf61cmx 277 1 murine murine JJ cord-348746-yaf61cmx 277 2 hepatitis hepatitis NN cord-348746-yaf61cmx 277 3 virus virus NN cord-348746-yaf61cmx 277 4 JHM JHM NNP cord-348746-yaf61cmx 277 5 strain strain NN cord-348746-yaf61cmx 277 6 ( ( -LRB- cord-348746-yaf61cmx 277 7 MHV-4 MHV-4 NNP cord-348746-yaf61cmx 277 8 ) ) -RRB- cord-348746-yaf61cmx 277 9 is be VBZ cord-348746-yaf61cmx 277 10 immunologically immunologically RB cord-348746-yaf61cmx 277 11 mediated mediate VBN cord-348746-yaf61cmx 277 12 Population population NN cord-348746-yaf61cmx 277 13 dynamics dynamic NNS cord-348746-yaf61cmx 277 14 of of IN cord-348746-yaf61cmx 277 15 lymphocyte lymphocyte NN cord-348746-yaf61cmx 277 16 subsets subset NNS cord-348746-yaf61cmx 277 17 in in IN cord-348746-yaf61cmx 277 18 the the DT cord-348746-yaf61cmx 277 19 central central JJ cord-348746-yaf61cmx 277 20 nervous nervous JJ cord-348746-yaf61cmx 277 21 system system NN cord-348746-yaf61cmx 277 22 of of IN cord-348746-yaf61cmx 277 23 rats rat NNS cord-348746-yaf61cmx 277 24 with with IN cord-348746-yaf61cmx 277 25 different different JJ cord-348746-yaf61cmx 277 26 susceptibility susceptibility NN cord-348746-yaf61cmx 277 27 to to IN cord-348746-yaf61cmx 277 28 coronavirus coronavirus NN cord-348746-yaf61cmx 277 29 - - HYPH cord-348746-yaf61cmx 277 30 induced induce VBN cord-348746-yaf61cmx 277 31 demyelinating demyelinate VBG cord-348746-yaf61cmx 277 32 encephalitis encephalitis RB cord-348746-yaf61cmx 277 33 Mouse Mouse NNP cord-348746-yaf61cmx 277 34 hepatitis hepatitis NN cord-348746-yaf61cmx 277 35 virus virus NN cord-348746-yaf61cmx 277 36 - - HYPH cord-348746-yaf61cmx 277 37 specific specific JJ cord-348746-yaf61cmx 277 38 cytotoxic cytotoxic JJ cord-348746-yaf61cmx 277 39 T t NN cord-348746-yaf61cmx 277 40 lymphocytes lymphocyte NNS cord-348746-yaf61cmx 277 41 protect protect VBP cord-348746-yaf61cmx 277 42 from from IN cord-348746-yaf61cmx 277 43 lethal lethal JJ cord-348746-yaf61cmx 277 44 infection infection NN cord-348746-yaf61cmx 277 45 without without IN cord-348746-yaf61cmx 277 46 eliminating eliminate VBG cord-348746-yaf61cmx 277 47 virus virus NN cord-348746-yaf61cmx 277 48 from from IN cord-348746-yaf61cmx 277 49 the the DT cord-348746-yaf61cmx 277 50 central central JJ cord-348746-yaf61cmx 277 51 nervous nervous JJ cord-348746-yaf61cmx 277 52 system system NN cord-348746-yaf61cmx 277 53 Coronavirus Coronavirus NNP cord-348746-yaf61cmx 277 54 - - HYPH cord-348746-yaf61cmx 277 55 induced induce VBN cord-348746-yaf61cmx 277 56 demyelination demyelination NN cord-348746-yaf61cmx 277 57 occurs occur VBZ cord-348746-yaf61cmx 277 58 in in IN cord-348746-yaf61cmx 277 59 the the DT cord-348746-yaf61cmx 277 60 presence presence NN cord-348746-yaf61cmx 277 61 of of IN cord-348746-yaf61cmx 277 62 virus virus NN cord-348746-yaf61cmx 277 63 - - HYPH cord-348746-yaf61cmx 277 64 specific specific JJ cord-348746-yaf61cmx 277 65 cytotoxic cytotoxic JJ cord-348746-yaf61cmx 277 66 T t NN cord-348746-yaf61cmx 277 67 cells cell NNS cord-348746-yaf61cmx 277 68 Infection infection NN cord-348746-yaf61cmx 277 69 with with IN cord-348746-yaf61cmx 277 70 cytotoxic cytotoxic JJ cord-348746-yaf61cmx 277 71 T t NN cord-348746-yaf61cmx 277 72 - - HYPH cord-348746-yaf61cmx 277 73 lymphocyte lymphocyte NN cord-348746-yaf61cmx 277 74 escape escape NN cord-348746-yaf61cmx 277 75 mutants mutant NNS cord-348746-yaf61cmx 277 76 results result NNS cord-348746-yaf61cmx 277 77 in in IN cord-348746-yaf61cmx 277 78 increased increase VBN cord-348746-yaf61cmx 277 79 mortality mortality NN cord-348746-yaf61cmx 277 80 and and CC cord-348746-yaf61cmx 277 81 growth growth NN cord-348746-yaf61cmx 277 82 retardation retardation NN cord-348746-yaf61cmx 277 83 in in IN cord-348746-yaf61cmx 277 84 mice mouse NNS cord-348746-yaf61cmx 277 85 infected infect VBN cord-348746-yaf61cmx 277 86 with with IN cord-348746-yaf61cmx 277 87 a a DT cord-348746-yaf61cmx 277 88 neurotropic neurotropic JJ cord-348746-yaf61cmx 277 89 coronavirus coronavirus NN cord-348746-yaf61cmx 277 90 Apoptosis Apoptosis NNP cord-348746-yaf61cmx 277 91 induced induce VBN cord-348746-yaf61cmx 277 92 in in IN cord-348746-yaf61cmx 277 93 mouse mouse NN cord-348746-yaf61cmx 277 94 hepatitis hepatitis NNP cord-348746-yaf61cmx 277 95 virus virus NN cord-348746-yaf61cmx 277 96 - - HYPH cord-348746-yaf61cmx 277 97 infected infect VBN cord-348746-yaf61cmx 277 98 cells cell NNS cord-348746-yaf61cmx 277 99 by by IN cord-348746-yaf61cmx 277 100 a a DT cord-348746-yaf61cmx 277 101 virus virus NN cord-348746-yaf61cmx 277 102 - - HYPH cord-348746-yaf61cmx 277 103 specific specific JJ cord-348746-yaf61cmx 277 104 CD8ϩ CD8ϩ NNP cord-348746-yaf61cmx 277 105 cytotoxic cytotoxic JJ cord-348746-yaf61cmx 278 1 Tlymphocyte tlymphocyte DT cord-348746-yaf61cmx 278 2 clone clone NN cord-348746-yaf61cmx 278 3 Apoptosis apoptosis NN cord-348746-yaf61cmx 278 4 of of IN cord-348746-yaf61cmx 278 5 T T NNP cord-348746-yaf61cmx 278 6 lymphocytes lymphocyte NNS cord-348746-yaf61cmx 278 7 in in IN cord-348746-yaf61cmx 278 8 experimental experimental JJ cord-348746-yaf61cmx 278 9 autoimmune autoimmune JJ cord-348746-yaf61cmx 278 10 encephalomyelitis encephalomyelitis NN cord-348746-yaf61cmx 278 11 . . . cord-348746-yaf61cmx 279 1 Evidence evidence NN cord-348746-yaf61cmx 279 2 for for IN cord-348746-yaf61cmx 279 3 programmed programmed JJ cord-348746-yaf61cmx 279 4 cell cell NN cord-348746-yaf61cmx 279 5 death death NN cord-348746-yaf61cmx 279 6 as as IN cord-348746-yaf61cmx 279 7 a a DT cord-348746-yaf61cmx 279 8 mechanism mechanism NN cord-348746-yaf61cmx 279 9 to to TO cord-348746-yaf61cmx 279 10 control control VB cord-348746-yaf61cmx 279 11 inflammation inflammation NN cord-348746-yaf61cmx 279 12 in in IN cord-348746-yaf61cmx 279 13 the the DT cord-348746-yaf61cmx 279 14 brain brain NN cord-348746-yaf61cmx 279 15 Nucleocapsid nucleocapsid NN cord-348746-yaf61cmx 279 16 or or CC cord-348746-yaf61cmx 279 17 spike spike NN cord-348746-yaf61cmx 279 18 protein protein NN cord-348746-yaf61cmx 279 19 - - HYPH cord-348746-yaf61cmx 279 20 specific specific JJ cord-348746-yaf61cmx 279 21 CD4ϩ CD4ϩ NNP cord-348746-yaf61cmx 279 22 T t NN cord-348746-yaf61cmx 279 23 lymphocytes lymphocyte NNS cord-348746-yaf61cmx 279 24 protect protect VBP cord-348746-yaf61cmx 279 25 against against IN cord-348746-yaf61cmx 279 26 coronavirus coronavirus NN cord-348746-yaf61cmx 279 27 - - HYPH cord-348746-yaf61cmx 279 28 induced induce VBN cord-348746-yaf61cmx 279 29 encephalomyelitis encephalomyelitis NN cord-348746-yaf61cmx 279 30 in in IN cord-348746-yaf61cmx 279 31 the the DT cord-348746-yaf61cmx 279 32 absence absence NN cord-348746-yaf61cmx 279 33 of of IN cord-348746-yaf61cmx 279 34 CD8ϩ CD8ϩ NNP cord-348746-yaf61cmx 279 35 T T NNP cord-348746-yaf61cmx 279 36 cells cell NNS cord-348746-yaf61cmx 279 37 T t NN cord-348746-yaf61cmx 279 38 - - HYPH cord-348746-yaf61cmx 279 39 cell cell NN cord-348746-yaf61cmx 279 40 - - HYPH cord-348746-yaf61cmx 279 41 mediated mediate VBN cord-348746-yaf61cmx 279 42 clearance clearance NN cord-348746-yaf61cmx 279 43 of of IN cord-348746-yaf61cmx 279 44 mouse mouse NN cord-348746-yaf61cmx 279 45 hepatitis hepatitis NNP cord-348746-yaf61cmx 279 46 virus virus NN cord-348746-yaf61cmx 279 47 strain strain VBP cord-348746-yaf61cmx 279 48 JHM JHM NNP cord-348746-yaf61cmx 279 49 from from IN cord-348746-yaf61cmx 279 50 the the DT cord-348746-yaf61cmx 279 51 central central JJ cord-348746-yaf61cmx 279 52 nervous nervous JJ cord-348746-yaf61cmx 279 53 system system NN cord-348746-yaf61cmx 279 54 Effective effective JJ cord-348746-yaf61cmx 279 55 clearance clearance NN cord-348746-yaf61cmx 279 56 of of IN cord-348746-yaf61cmx 279 57 mouse mouse NN cord-348746-yaf61cmx 279 58 hepatitis hepatitis NN cord-348746-yaf61cmx 279 59 virus virus NN cord-348746-yaf61cmx 279 60 from from IN cord-348746-yaf61cmx 279 61 the the DT cord-348746-yaf61cmx 279 62 central central JJ cord-348746-yaf61cmx 279 63 nervous nervous JJ cord-348746-yaf61cmx 279 64 system system NN cord-348746-yaf61cmx 279 65 requires require VBZ cord-348746-yaf61cmx 279 66 both both CC cord-348746-yaf61cmx 279 67 CD4ϩ CD4ϩ NNP cord-348746-yaf61cmx 279 68 and and CC cord-348746-yaf61cmx 279 69 CD8ϩ CD8ϩ NNP cord-348746-yaf61cmx 279 70 T T NNP cord-348746-yaf61cmx 279 71 cells cell NNS cord-348746-yaf61cmx 279 72 On on IN cord-348746-yaf61cmx 279 73 the the DT cord-348746-yaf61cmx 279 74 role role NN cord-348746-yaf61cmx 279 75 of of IN cord-348746-yaf61cmx 279 76 different different JJ cord-348746-yaf61cmx 279 77 lymphocyte lymphocyte NN cord-348746-yaf61cmx 279 78 subpopulations subpopulation NNS cord-348746-yaf61cmx 279 79 in in IN cord-348746-yaf61cmx 279 80 the the DT cord-348746-yaf61cmx 279 81 course course NN cord-348746-yaf61cmx 279 82 of of IN cord-348746-yaf61cmx 279 83 coronavirus coronavirus NN cord-348746-yaf61cmx 279 84 MHV MHV NNP cord-348746-yaf61cmx 279 85 IV IV NNP cord-348746-yaf61cmx 279 86 ( ( -LRB- cord-348746-yaf61cmx 279 87 JHM)-induced jhm)-induce VBN cord-348746-yaf61cmx 279 88 encephalitis encephalitis RB cord-348746-yaf61cmx 279 89 in in IN cord-348746-yaf61cmx 279 90 Lewis Lewis NNP cord-348746-yaf61cmx 279 91 rats rat NNS cord-348746-yaf61cmx 280 1 A a DT cord-348746-yaf61cmx 280 2 central central JJ cord-348746-yaf61cmx 280 3 role role NN cord-348746-yaf61cmx 280 4 for for IN cord-348746-yaf61cmx 280 5 CD4(ϩ CD4(ϩ NNP cord-348746-yaf61cmx 280 6 ) ) -RRB- cord-348746-yaf61cmx 280 7 T t NN cord-348746-yaf61cmx 280 8 cells cell NNS cord-348746-yaf61cmx 280 9 and and CC cord-348746-yaf61cmx 280 10 RANTES RANTES NNPS cord-348746-yaf61cmx 280 11 in in IN cord-348746-yaf61cmx 280 12 virus virus NN cord-348746-yaf61cmx 280 13 - - HYPH cord-348746-yaf61cmx 280 14 induced induce VBN cord-348746-yaf61cmx 280 15 central central JJ cord-348746-yaf61cmx 280 16 nervous nervous JJ cord-348746-yaf61cmx 280 17 system system NN cord-348746-yaf61cmx 280 18 inflammation inflammation NN cord-348746-yaf61cmx 280 19 and and CC cord-348746-yaf61cmx 280 20 demyelination demyelination NN cord-348746-yaf61cmx 280 21 Spread spread NN cord-348746-yaf61cmx 280 22 of of IN cord-348746-yaf61cmx 280 23 MHV MHV NNP cord-348746-yaf61cmx 280 24 - - HYPH cord-348746-yaf61cmx 280 25 JHM JHM NNP cord-348746-yaf61cmx 280 26 from from IN cord-348746-yaf61cmx 280 27 nasal nasal NN cord-348746-yaf61cmx 280 28 cavity cavity NN cord-348746-yaf61cmx 280 29 to to IN cord-348746-yaf61cmx 280 30 white white JJ cord-348746-yaf61cmx 280 31 matter matter NN cord-348746-yaf61cmx 280 32 of of IN cord-348746-yaf61cmx 280 33 spinal spinal JJ cord-348746-yaf61cmx 280 34 cord cord NN cord-348746-yaf61cmx 280 35 Activation Activation NNP cord-348746-yaf61cmx 280 36 of of IN cord-348746-yaf61cmx 280 37 astrocytes astrocyte NNS cord-348746-yaf61cmx 280 38 in in IN cord-348746-yaf61cmx 280 39 the the DT cord-348746-yaf61cmx 280 40 spinal spinal JJ cord-348746-yaf61cmx 280 41 cord cord NN cord-348746-yaf61cmx 280 42 of of IN cord-348746-yaf61cmx 280 43 mice mouse NNS cord-348746-yaf61cmx 280 44 chronically chronically RB cord-348746-yaf61cmx 280 45 infected infect VBN cord-348746-yaf61cmx 280 46 with with IN cord-348746-yaf61cmx 280 47 a a DT cord-348746-yaf61cmx 280 48 neurotropic neurotropic JJ cord-348746-yaf61cmx 280 49 coronavirus coronavirus NN cord-348746-yaf61cmx 280 50 Tumor tumor NN cord-348746-yaf61cmx 280 51 necrosis necrosis NN cord-348746-yaf61cmx 280 52 factor factor NN cord-348746-yaf61cmx 280 53 , , , cord-348746-yaf61cmx 280 54 other other JJ cord-348746-yaf61cmx 280 55 cytokines cytokine NNS cord-348746-yaf61cmx 280 56 and and CC cord-348746-yaf61cmx 280 57 disease disease NN cord-348746-yaf61cmx 281 1 Interleukin-6 Interleukin-6 NNP cord-348746-yaf61cmx 281 2 : : : cord-348746-yaf61cmx 282 1 A a DT cord-348746-yaf61cmx 282 2 comprehensive comprehensive JJ cord-348746-yaf61cmx 282 3 review review NN cord-348746-yaf61cmx 283 1 IL-6-deficient il-6-deficient NN cord-348746-yaf61cmx 283 2 mice mouse NNS cord-348746-yaf61cmx 283 3 are be VBP cord-348746-yaf61cmx 283 4 resistant resistant JJ cord-348746-yaf61cmx 283 5 to to IN cord-348746-yaf61cmx 283 6 experimental experimental JJ cord-348746-yaf61cmx 283 7 autoimmune autoimmune JJ cord-348746-yaf61cmx 283 8 encephalomyelitis encephalomyelitis NN cord-348746-yaf61cmx 283 9 : : : cord-348746-yaf61cmx 284 1 Roles role NNS cord-348746-yaf61cmx 284 2 of of IN cord-348746-yaf61cmx 284 3 IL-6 IL-6 NNP cord-348746-yaf61cmx 284 4 in in IN cord-348746-yaf61cmx 284 5 the the DT cord-348746-yaf61cmx 284 6 activation activation NN cord-348746-yaf61cmx 284 7 and and CC cord-348746-yaf61cmx 284 8 differentiation differentiation NN cord-348746-yaf61cmx 284 9 of of IN cord-348746-yaf61cmx 284 10 autoreactive autoreactive JJ cord-348746-yaf61cmx 284 11 T t NN cord-348746-yaf61cmx 284 12 cells cell NNS cord-348746-yaf61cmx 285 1 Interleukin-6 Interleukin-6 VBN cord-348746-yaf61cmx 285 2 in in IN cord-348746-yaf61cmx 285 3 biology biology NN cord-348746-yaf61cmx 285 4 and and CC cord-348746-yaf61cmx 285 5 medicine medicine NN cord-348746-yaf61cmx 286 1 IL-6 IL-6 NNP cord-348746-yaf61cmx 286 2 and and CC cord-348746-yaf61cmx 286 3 APPs app NNS cord-348746-yaf61cmx 286 4 : : : cord-348746-yaf61cmx 286 5 Anti anti JJ cord-348746-yaf61cmx 286 6 - - JJ cord-348746-yaf61cmx 286 7 inflammatory inflammatory JJ cord-348746-yaf61cmx 286 8 and and CC cord-348746-yaf61cmx 286 9 immunosuppressive immunosuppressive JJ cord-348746-yaf61cmx 286 10 mediators mediator NNS cord-348746-yaf61cmx 286 11 Kinetics kinetic NNS cord-348746-yaf61cmx 286 12 of of IN cord-348746-yaf61cmx 286 13 cytokine cytokine NN cord-348746-yaf61cmx 286 14 mRNA mrna NN cord-348746-yaf61cmx 286 15 expression expression NN cord-348746-yaf61cmx 286 16 in in IN cord-348746-yaf61cmx 286 17 the the DT cord-348746-yaf61cmx 286 18 central central JJ cord-348746-yaf61cmx 286 19 nervous nervous JJ cord-348746-yaf61cmx 286 20 system system NN cord-348746-yaf61cmx 286 21 following follow VBG cord-348746-yaf61cmx 286 22 lethal lethal JJ cord-348746-yaf61cmx 286 23 and and CC cord-348746-yaf61cmx 286 24 nonlethal nonlethal JJ cord-348746-yaf61cmx 286 25 coronavirus coronavirus NN cord-348746-yaf61cmx 286 26 - - HYPH cord-348746-yaf61cmx 286 27 induced induce VBN cord-348746-yaf61cmx 286 28 acute acute JJ cord-348746-yaf61cmx 286 29 encephalomyelitis encephalomyelitis NN cord-348746-yaf61cmx 287 1 The the DT cord-348746-yaf61cmx 287 2 role role NN cord-348746-yaf61cmx 287 3 of of IN cord-348746-yaf61cmx 287 4 IL-10 IL-10 NNP cord-348746-yaf61cmx 287 5 in in IN cord-348746-yaf61cmx 287 6 mouse mouse NN cord-348746-yaf61cmx 287 7 hepatitis hepatitis NN cord-348746-yaf61cmx 287 8 virus virus NN cord-348746-yaf61cmx 287 9 - - HYPH cord-348746-yaf61cmx 287 10 induced induce VBN cord-348746-yaf61cmx 287 11 demyelinating demyelinate VBG cord-348746-yaf61cmx 287 12 encephalomyelitis encephalomyelitis NN cord-348746-yaf61cmx 287 13 IFN IFN NNP cord-348746-yaf61cmx 287 14 - - HYPH cord-348746-yaf61cmx 287 15 gamma gamma NNP cord-348746-yaf61cmx 287 16 is be VBZ cord-348746-yaf61cmx 287 17 required require VBN cord-348746-yaf61cmx 287 18 for for IN cord-348746-yaf61cmx 287 19 viral viral JJ cord-348746-yaf61cmx 287 20 clearance clearance NN cord-348746-yaf61cmx 287 21 from from IN cord-348746-yaf61cmx 287 22 central central JJ cord-348746-yaf61cmx 287 23 nervous nervous JJ cord-348746-yaf61cmx 287 24 system system NN cord-348746-yaf61cmx 287 25 oligodendroglia oligodendroglia NNP cord-348746-yaf61cmx 288 1 The the DT cord-348746-yaf61cmx 288 2 role role NN cord-348746-yaf61cmx 288 3 of of IN cord-348746-yaf61cmx 288 4 gamma gamma NN cord-348746-yaf61cmx 288 5 interferon interferon NN cord-348746-yaf61cmx 288 6 in in IN cord-348746-yaf61cmx 288 7 infection infection NN cord-348746-yaf61cmx 288 8 of of IN cord-348746-yaf61cmx 288 9 susceptible susceptible JJ cord-348746-yaf61cmx 288 10 mice mouse NNS cord-348746-yaf61cmx 288 11 with with IN cord-348746-yaf61cmx 288 12 murine murine JJ cord-348746-yaf61cmx 288 13 coronavirus coronavirus NN cord-348746-yaf61cmx 288 14 , , , cord-348746-yaf61cmx 288 15 MHV MHV NNP cord-348746-yaf61cmx 288 16 - - HYPH cord-348746-yaf61cmx 288 17 JHM JHM NNP cord-348746-yaf61cmx 289 1 Interferon interferon NN cord-348746-yaf61cmx 289 2 gamma gamma NN cord-348746-yaf61cmx 289 3 potentiates potentiate VBZ cord-348746-yaf61cmx 289 4 human human JJ cord-348746-yaf61cmx 289 5 coronavirus coronavirus NN cord-348746-yaf61cmx 289 6 OC43 OC43 NNP cord-348746-yaf61cmx 289 7 infection infection NN cord-348746-yaf61cmx 289 8 of of IN cord-348746-yaf61cmx 289 9 neuronal neuronal JJ cord-348746-yaf61cmx 289 10 cells cell NNS cord-348746-yaf61cmx 289 11 by by IN cord-348746-yaf61cmx 289 12 modulation modulation NN cord-348746-yaf61cmx 289 13 of of IN cord-348746-yaf61cmx 290 1 HLA HLA NNP cord-348746-yaf61cmx 290 2 class class NN cord-348746-yaf61cmx 290 3 I -PRON- PRP cord-348746-yaf61cmx 290 4 expression expression VBP cord-348746-yaf61cmx 290 5 Dynamic dynamic JJ cord-348746-yaf61cmx 290 6 regulation regulation NN cord-348746-yaf61cmx 290 7 of of IN cord-348746-yaf61cmx 290 8 alpha alpha NN cord-348746-yaf61cmx 290 9 - - HYPH cord-348746-yaf61cmx 290 10 and and CC cord-348746-yaf61cmx 290 11 beta beta JJ cord-348746-yaf61cmx 290 12 - - HYPH cord-348746-yaf61cmx 290 13 chemokine chemokine NN cord-348746-yaf61cmx 290 14 expression expression NN cord-348746-yaf61cmx 290 15 in in IN cord-348746-yaf61cmx 290 16 the the DT cord-348746-yaf61cmx 290 17 central central JJ cord-348746-yaf61cmx 290 18 nervous nervous JJ cord-348746-yaf61cmx 290 19 system system NN cord-348746-yaf61cmx 290 20 during during IN cord-348746-yaf61cmx 290 21 mouse mouse NNP cord-348746-yaf61cmx 290 22 hepatitis hepatitis NNP cord-348746-yaf61cmx 290 23 virus virus NN cord-348746-yaf61cmx 290 24 - - HYPH cord-348746-yaf61cmx 290 25 induced induce VBN cord-348746-yaf61cmx 290 26 demyelinating demyelinate VBG cord-348746-yaf61cmx 290 27 disease disease NN cord-348746-yaf61cmx 290 28 Chemokine chemokine JJ cord-348746-yaf61cmx 290 29 expression expression NN cord-348746-yaf61cmx 290 30 in in IN cord-348746-yaf61cmx 290 31 simian simian JJ cord-348746-yaf61cmx 290 32 immunodeficiency immunodeficiency NN cord-348746-yaf61cmx 290 33 virus virus NN cord-348746-yaf61cmx 290 34 - - HYPH cord-348746-yaf61cmx 290 35 induced induce VBN cord-348746-yaf61cmx 290 36 AIDS AIDS NNP cord-348746-yaf61cmx 290 37 encephalitis encephalitis RB cord-348746-yaf61cmx 290 38 Chemokine Chemokine NNP cord-348746-yaf61cmx 290 39 gene gene NN cord-348746-yaf61cmx 290 40 expression expression NN cord-348746-yaf61cmx 290 41 in in IN cord-348746-yaf61cmx 290 42 the the DT cord-348746-yaf61cmx 290 43 brains brain NNS cord-348746-yaf61cmx 290 44 of of IN cord-348746-yaf61cmx 290 45 mice mouse NNS cord-348746-yaf61cmx 290 46 with with IN cord-348746-yaf61cmx 290 47 lymphocytic lymphocytic JJ cord-348746-yaf61cmx 290 48 choriomeningitis choriomeningitis NNP cord-348746-yaf61cmx 290 49 Vaccination Vaccination NNP cord-348746-yaf61cmx 290 50 against against IN cord-348746-yaf61cmx 290 51 naturally naturally RB cord-348746-yaf61cmx 290 52 occurring occur VBG cord-348746-yaf61cmx 290 53 FIP fip NN cord-348746-yaf61cmx 290 54 in in IN cord-348746-yaf61cmx 290 55 a a DT cord-348746-yaf61cmx 290 56 single single JJ cord-348746-yaf61cmx 290 57 large large JJ cord-348746-yaf61cmx 290 58 cat cat NN cord-348746-yaf61cmx 290 59 shelter shelter NN cord-348746-yaf61cmx 290 60 Overview Overview NNP cord-348746-yaf61cmx 290 61 of of IN cord-348746-yaf61cmx 290 62 the the DT cord-348746-yaf61cmx 290 63 development development NN cord-348746-yaf61cmx 290 64 of of IN cord-348746-yaf61cmx 290 65 a a DT cord-348746-yaf61cmx 290 66 modified modify VBN cord-348746-yaf61cmx 290 67 live live JJ cord-348746-yaf61cmx 290 68 temperature temperature NN cord-348746-yaf61cmx 290 69 - - HYPH cord-348746-yaf61cmx 290 70 sensitive sensitive JJ cord-348746-yaf61cmx 290 71 FIP FIP NNP cord-348746-yaf61cmx 290 72 virus virus NN cord-348746-yaf61cmx 290 73 vaccine vaccine NN cord-348746-yaf61cmx 290 74 Independent independent JJ cord-348746-yaf61cmx 290 75 evaluation evaluation NN cord-348746-yaf61cmx 290 76 of of IN cord-348746-yaf61cmx 290 77 a a DT cord-348746-yaf61cmx 290 78 modified modify VBN cord-348746-yaf61cmx 290 79 live live JJ cord-348746-yaf61cmx 290 80 feline feline JJ cord-348746-yaf61cmx 290 81 infectious infectious JJ cord-348746-yaf61cmx 290 82 peritonitis peritonitis NN cord-348746-yaf61cmx 290 83 virus virus NN cord-348746-yaf61cmx 290 84 vaccine vaccine NN cord-348746-yaf61cmx 290 85 under under IN cord-348746-yaf61cmx 290 86 experimental experimental JJ cord-348746-yaf61cmx 290 87 conditions condition NNS cord-348746-yaf61cmx 290 88 ( ( -LRB- cord-348746-yaf61cmx 290 89 University University NNP cord-348746-yaf61cmx 290 90 of of IN cord-348746-yaf61cmx 290 91 Liverpool Liverpool NNP cord-348746-yaf61cmx 290 92 experience experience NN cord-348746-yaf61cmx 290 93 ) ) -RRB- cord-348746-yaf61cmx 291 1 Independent independent JJ cord-348746-yaf61cmx 291 2 evaluation evaluation NN cord-348746-yaf61cmx 291 3 of of IN cord-348746-yaf61cmx 291 4 a a DT cord-348746-yaf61cmx 291 5 modified modified JJ cord-348746-yaf61cmx 291 6 live live JJ cord-348746-yaf61cmx 291 7 FIPV FIPV NNS cord-348746-yaf61cmx 291 8 vaccine vaccine NN cord-348746-yaf61cmx 291 9 under under IN cord-348746-yaf61cmx 291 10 experimental experimental JJ cord-348746-yaf61cmx 291 11 conditions condition NNS cord-348746-yaf61cmx 291 12 ( ( -LRB- cord-348746-yaf61cmx 291 13 Cornell Cornell NNP cord-348746-yaf61cmx 291 14 experience experience NN cord-348746-yaf61cmx 291 15 ) ) -RRB- cord-348746-yaf61cmx 292 1 Protection protection NN cord-348746-yaf61cmx 292 2 from from IN cord-348746-yaf61cmx 292 3 lethal lethal JJ cord-348746-yaf61cmx 292 4 coronavirus coronavirus NN cord-348746-yaf61cmx 292 5 infection infection NN cord-348746-yaf61cmx 292 6 by by IN cord-348746-yaf61cmx 292 7 affinity affinity NN cord-348746-yaf61cmx 292 8 - - HYPH cord-348746-yaf61cmx 292 9 purified purify VBN cord-348746-yaf61cmx 292 10 spike spike NN cord-348746-yaf61cmx 292 11 glycoprotein glycoprotein NN cord-348746-yaf61cmx 292 12 of of IN cord-348746-yaf61cmx 292 13 murine murine JJ cord-348746-yaf61cmx 292 14 hepatitis hepatitis NN cord-348746-yaf61cmx 292 15 virus virus NN cord-348746-yaf61cmx 292 16 , , , cord-348746-yaf61cmx 292 17 strain strain VB cord-348746-yaf61cmx 292 18 A59 A59 NNP cord-348746-yaf61cmx 292 19 Vaccination vaccination NN cord-348746-yaf61cmx 292 20 against against IN cord-348746-yaf61cmx 292 21 lethal lethal JJ cord-348746-yaf61cmx 292 22 coronavirus coronavirus NN cord-348746-yaf61cmx 292 23 - - HYPH cord-348746-yaf61cmx 292 24 induced induce VBN cord-348746-yaf61cmx 292 25 encephalitis encephalitis RB cord-348746-yaf61cmx 292 26 with with IN cord-348746-yaf61cmx 292 27 a a DT cord-348746-yaf61cmx 292 28 synthetic synthetic JJ cord-348746-yaf61cmx 292 29 decapeptide decapeptide NN cord-348746-yaf61cmx 292 30 homologous homologous JJ cord-348746-yaf61cmx 292 31 to to IN cord-348746-yaf61cmx 292 32 a a DT cord-348746-yaf61cmx 292 33 domain domain NN cord-348746-yaf61cmx 292 34 in in IN cord-348746-yaf61cmx 292 35 the the DT cord-348746-yaf61cmx 292 36 predicted predict VBN cord-348746-yaf61cmx 292 37 peplomer peplomer NN cord-348746-yaf61cmx 292 38 stalk stalk VB cord-348746-yaf61cmx 292 39 Immunogenic immunogenic JJ cord-348746-yaf61cmx 292 40 peptide peptide NN cord-348746-yaf61cmx 292 41 comprising comprise VBG cord-348746-yaf61cmx 292 42 a a DT cord-348746-yaf61cmx 292 43 mouse mouse NN cord-348746-yaf61cmx 292 44 hepatitis hepatitis NN cord-348746-yaf61cmx 292 45 virus virus NN cord-348746-yaf61cmx 292 46 A59 A59 NNP cord-348746-yaf61cmx 292 47 B b NN cord-348746-yaf61cmx 292 48 - - HYPH cord-348746-yaf61cmx 292 49 cell cell NN cord-348746-yaf61cmx 292 50 epitope epitope NN cord-348746-yaf61cmx 292 51 and and CC cord-348746-yaf61cmx 292 52 an an DT cord-348746-yaf61cmx 292 53 influenza influenza NN cord-348746-yaf61cmx 292 54 virus virus NN cord-348746-yaf61cmx 292 55 T t NN cord-348746-yaf61cmx 292 56 - - HYPH cord-348746-yaf61cmx 292 57 cell cell NN cord-348746-yaf61cmx 292 58 epitope epitope NN cord-348746-yaf61cmx 292 59 protects protect VBZ cord-348746-yaf61cmx 292 60 against against IN cord-348746-yaf61cmx 292 61 lethal lethal JJ cord-348746-yaf61cmx 292 62 infection infection NN cord-348746-yaf61cmx 292 63 Protective protective JJ cord-348746-yaf61cmx 292 64 immunity immunity NN cord-348746-yaf61cmx 292 65 against against IN cord-348746-yaf61cmx 292 66 murine murine JJ cord-348746-yaf61cmx 292 67 hepatitis hepatitis NN cord-348746-yaf61cmx 292 68 virus virus NN cord-348746-yaf61cmx 292 69 ( ( -LRB- cord-348746-yaf61cmx 292 70 MHV mhv NN cord-348746-yaf61cmx 292 71 ) ) -RRB- cord-348746-yaf61cmx 292 72 induced induce VBN cord-348746-yaf61cmx 292 73 by by IN cord-348746-yaf61cmx 292 74 intranasal intranasal NN cord-348746-yaf61cmx 292 75 or or CC cord-348746-yaf61cmx 292 76 subcutaneous subcutaneous JJ cord-348746-yaf61cmx 292 77 administration administration NN cord-348746-yaf61cmx 292 78 of of IN cord-348746-yaf61cmx 292 79 hybrids hybrid NNS cord-348746-yaf61cmx 292 80 of of IN cord-348746-yaf61cmx 292 81 tobacco tobacco NN cord-348746-yaf61cmx 292 82 mosaic mosaic JJ cord-348746-yaf61cmx 292 83 virus virus NN cord-348746-yaf61cmx 292 84 that that WDT cord-348746-yaf61cmx 292 85 carries carry VBZ cord-348746-yaf61cmx 292 86 an an DT cord-348746-yaf61cmx 292 87 MHV MHV NNP cord-348746-yaf61cmx 292 88 epitope epitope NN cord-348746-yaf61cmx 292 89 Adjunctive Adjunctive NNP cord-348746-yaf61cmx 292 90 therapy therapy NN cord-348746-yaf61cmx 292 91 for for IN cord-348746-yaf61cmx 292 92 bacterial bacterial JJ cord-348746-yaf61cmx 292 93 meningitis meningitis NN cord-348746-yaf61cmx 292 94 : : : cord-348746-yaf61cmx 292 95 Rationale rationale NN cord-348746-yaf61cmx 292 96 for for IN cord-348746-yaf61cmx 292 97 use use NN cord-348746-yaf61cmx 292 98 , , , cord-348746-yaf61cmx 292 99 current current JJ cord-348746-yaf61cmx 292 100 status status NN cord-348746-yaf61cmx 292 101 , , , cord-348746-yaf61cmx 292 102 and and CC cord-348746-yaf61cmx 292 103 prospects prospect NNS cord-348746-yaf61cmx 292 104 for for IN cord-348746-yaf61cmx 292 105 the the DT cord-348746-yaf61cmx 292 106 future future NN