id sid tid token lemma pos cord-352379-q5inrxcm 1 1 key key JJ cord-352379-q5inrxcm 2 1 : : : cord-352379-q5inrxcm 2 2 cord-352379-q5inrxcm cord-352379-q5inrxcm DT cord-352379-q5inrxcm 2 3 authors author NNS cord-352379-q5inrxcm 2 4 : : : cord-352379-q5inrxcm 2 5 Lai Lai NNP cord-352379-q5inrxcm 2 6 , , , cord-352379-q5inrxcm 2 7 Michael Michael NNP cord-352379-q5inrxcm 2 8 M. M. NNP cord-352379-q5inrxcm 2 9 C. C. NNP cord-352379-q5inrxcm 2 10 title title NN cord-352379-q5inrxcm 2 11 : : : cord-352379-q5inrxcm 2 12 SARS SARS NNP cord-352379-q5inrxcm 2 13 virus virus NN cord-352379-q5inrxcm 2 14 : : : cord-352379-q5inrxcm 3 1 The the DT cord-352379-q5inrxcm 3 2 beginning beginning NN cord-352379-q5inrxcm 3 3 of of IN cord-352379-q5inrxcm 3 4 the the DT cord-352379-q5inrxcm 3 5 unraveling unraveling NN cord-352379-q5inrxcm 3 6 of of IN cord-352379-q5inrxcm 3 7 a a DT cord-352379-q5inrxcm 3 8 new new JJ cord-352379-q5inrxcm 3 9 coronavirus coronavirus NN cord-352379-q5inrxcm 3 10 date date NN cord-352379-q5inrxcm 3 11 : : : cord-352379-q5inrxcm 3 12 2003 2003 CD cord-352379-q5inrxcm 3 13 - - SYM cord-352379-q5inrxcm 3 14 10 10 CD cord-352379-q5inrxcm 3 15 - - SYM cord-352379-q5inrxcm 3 16 17 17 CD cord-352379-q5inrxcm 3 17 journal journal NN cord-352379-q5inrxcm 3 18 : : : cord-352379-q5inrxcm 3 19 J J NNP cord-352379-q5inrxcm 3 20 Biomed Biomed NNP cord-352379-q5inrxcm 3 21 Sci Sci NNP cord-352379-q5inrxcm 3 22 DOI DOI NNP cord-352379-q5inrxcm 3 23 : : : cord-352379-q5inrxcm 3 24 10.1007 10.1007 CD cord-352379-q5inrxcm 3 25 / / SYM cord-352379-q5inrxcm 3 26 bf02256318 bf02256318 NNP cord-352379-q5inrxcm 3 27 sha sha NNP cord-352379-q5inrxcm 3 28 : : : cord-352379-q5inrxcm 4 1 16a6169ba53585a361d9417f73fbd0f7d87e7655 16a6169ba53585a361d9417f73fbd0f7d87e7655 CD cord-352379-q5inrxcm 4 2 doc_id doc_id CD cord-352379-q5inrxcm 4 3 : : : cord-352379-q5inrxcm 4 4 352379 352379 CD cord-352379-q5inrxcm 5 1 cord_uid cord_uid NN cord-352379-q5inrxcm 5 2 : : : cord-352379-q5inrxcm 6 1 q5inrxcm q5inrxcm NNP cord-352379-q5inrxcm 6 2 Severe severe JJ cord-352379-q5inrxcm 6 3 acute acute JJ cord-352379-q5inrxcm 6 4 respiratory respiratory JJ cord-352379-q5inrxcm 6 5 syndrome syndrome NN cord-352379-q5inrxcm 6 6 ( ( -LRB- cord-352379-q5inrxcm 6 7 SARS SARS NNP cord-352379-q5inrxcm 6 8 ) ) -RRB- cord-352379-q5inrxcm 6 9 virus virus NN cord-352379-q5inrxcm 6 10 caused cause VBD cord-352379-q5inrxcm 6 11 a a DT cord-352379-q5inrxcm 6 12 severe severe JJ cord-352379-q5inrxcm 6 13 outbreak outbreak NN cord-352379-q5inrxcm 6 14 in in IN cord-352379-q5inrxcm 6 15 several several JJ cord-352379-q5inrxcm 6 16 regions region NNS cord-352379-q5inrxcm 6 17 of of IN cord-352379-q5inrxcm 6 18 the the DT cord-352379-q5inrxcm 6 19 world world NN cord-352379-q5inrxcm 6 20 in in IN cord-352379-q5inrxcm 6 21 2003 2003 CD cord-352379-q5inrxcm 6 22 . . . cord-352379-q5inrxcm 7 1 The the DT cord-352379-q5inrxcm 7 2 virus virus NN cord-352379-q5inrxcm 7 3 is be VBZ cord-352379-q5inrxcm 7 4 a a DT cord-352379-q5inrxcm 7 5 novel novel JJ cord-352379-q5inrxcm 7 6 coronavirus coronavirus NN cord-352379-q5inrxcm 7 7 , , , cord-352379-q5inrxcm 7 8 which which WDT cord-352379-q5inrxcm 7 9 may may MD cord-352379-q5inrxcm 7 10 have have VB cord-352379-q5inrxcm 7 11 an an DT cord-352379-q5inrxcm 7 12 origin origin NN cord-352379-q5inrxcm 7 13 in in IN cord-352379-q5inrxcm 7 14 wild wild JJ cord-352379-q5inrxcm 7 15 animals animal NNS cord-352379-q5inrxcm 7 16 such such JJ cord-352379-q5inrxcm 7 17 as as IN cord-352379-q5inrxcm 7 18 civet civet NN cord-352379-q5inrxcm 7 19 cats cat NNS cord-352379-q5inrxcm 7 20 in in IN cord-352379-q5inrxcm 7 21 southern southern JJ cord-352379-q5inrxcm 7 22 China China NNP cord-352379-q5inrxcm 7 23 . . . cord-352379-q5inrxcm 8 1 Its -PRON- PRP$ cord-352379-q5inrxcm 8 2 genome genome NN cord-352379-q5inrxcm 8 3 structure structure NN cord-352379-q5inrxcm 8 4 , , , cord-352379-q5inrxcm 8 5 gene gene NN cord-352379-q5inrxcm 8 6 expression expression NN cord-352379-q5inrxcm 8 7 pattern pattern NN cord-352379-q5inrxcm 8 8 and and CC cord-352379-q5inrxcm 8 9 protein protein NN cord-352379-q5inrxcm 8 10 profiles profile NNS cord-352379-q5inrxcm 8 11 are be VBP cord-352379-q5inrxcm 8 12 similar similar JJ cord-352379-q5inrxcm 8 13 to to IN cord-352379-q5inrxcm 8 14 those those DT cord-352379-q5inrxcm 8 15 of of IN cord-352379-q5inrxcm 8 16 other other JJ cord-352379-q5inrxcm 8 17 coronaviruses coronaviruse NNS cord-352379-q5inrxcm 8 18 . . . cord-352379-q5inrxcm 9 1 However however RB cord-352379-q5inrxcm 9 2 , , , cord-352379-q5inrxcm 9 3 distinct distinct JJ cord-352379-q5inrxcm 9 4 patterns pattern NNS cord-352379-q5inrxcm 9 5 of of IN cord-352379-q5inrxcm 9 6 several several JJ cord-352379-q5inrxcm 9 7 open open JJ cord-352379-q5inrxcm 9 8 reading reading NN cord-352379-q5inrxcm 9 9 frames frame NNS cord-352379-q5inrxcm 9 10 in in IN cord-352379-q5inrxcm 9 11 the the DT cord-352379-q5inrxcm 9 12 SARS SARS NNP cord-352379-q5inrxcm 9 13 virus virus NN cord-352379-q5inrxcm 9 14 genome genome NN cord-352379-q5inrxcm 9 15 may may MD cord-352379-q5inrxcm 9 16 contribute contribute VB cord-352379-q5inrxcm 9 17 to to IN cord-352379-q5inrxcm 9 18 its -PRON- PRP$ cord-352379-q5inrxcm 9 19 severe severe JJ cord-352379-q5inrxcm 9 20 virulence virulence NN cord-352379-q5inrxcm 9 21 . . . cord-352379-q5inrxcm 10 1 The the DT cord-352379-q5inrxcm 10 2 potential potential JJ cord-352379-q5inrxcm 10 3 mutability mutability NN cord-352379-q5inrxcm 10 4 of of IN cord-352379-q5inrxcm 10 5 the the DT cord-352379-q5inrxcm 10 6 coronavirus coronavirus NN cord-352379-q5inrxcm 10 7 genome genome NN cord-352379-q5inrxcm 10 8 may may MD cord-352379-q5inrxcm 10 9 pose pose VB cord-352379-q5inrxcm 10 10 problems problem NNS cord-352379-q5inrxcm 10 11 in in IN cord-352379-q5inrxcm 10 12 the the DT cord-352379-q5inrxcm 10 13 control control NN cord-352379-q5inrxcm 10 14 of of IN cord-352379-q5inrxcm 10 15 future future JJ cord-352379-q5inrxcm 10 16 SARS SARS NNP cord-352379-q5inrxcm 10 17 outbreaks outbreak NNS cord-352379-q5inrxcm 10 18 . . . cord-352379-q5inrxcm 11 1 The the DT cord-352379-q5inrxcm 11 2 mechanism mechanism NN cord-352379-q5inrxcm 11 3 of of IN cord-352379-q5inrxcm 11 4 SARS SARS NNP cord-352379-q5inrxcm 11 5 pathogenesis pathogenesis NN cord-352379-q5inrxcm 11 6 may may MD cord-352379-q5inrxcm 11 7 involve involve VB cord-352379-q5inrxcm 11 8 both both DT cord-352379-q5inrxcm 11 9 direct direct JJ cord-352379-q5inrxcm 11 10 viral viral JJ cord-352379-q5inrxcm 11 11 cytocidal cytocidal NN cord-352379-q5inrxcm 11 12 effects effect NNS cord-352379-q5inrxcm 11 13 on on IN cord-352379-q5inrxcm 11 14 the the DT cord-352379-q5inrxcm 11 15 target target NN cord-352379-q5inrxcm 11 16 cells cell NNS cord-352379-q5inrxcm 11 17 and and CC cord-352379-q5inrxcm 11 18 immune immune NN cord-352379-q5inrxcm 11 19 - - HYPH cord-352379-q5inrxcm 11 20 mediated mediate VBN cord-352379-q5inrxcm 11 21 mechanisms mechanism NNS cord-352379-q5inrxcm 11 22 . . . cord-352379-q5inrxcm 12 1 The the DT cord-352379-q5inrxcm 12 2 life life NN cord-352379-q5inrxcm 12 3 cycle cycle NN cord-352379-q5inrxcm 12 4 of of IN cord-352379-q5inrxcm 12 5 the the DT cord-352379-q5inrxcm 12 6 SARS SARS NNP cord-352379-q5inrxcm 12 7 virus virus NN cord-352379-q5inrxcm 12 8 is be VBZ cord-352379-q5inrxcm 12 9 largely largely RB cord-352379-q5inrxcm 12 10 unknown unknown JJ cord-352379-q5inrxcm 12 11 ; ; : cord-352379-q5inrxcm 12 12 however however RB cord-352379-q5inrxcm 12 13 , , , cord-352379-q5inrxcm 12 14 based base VBN cord-352379-q5inrxcm 12 15 on on IN cord-352379-q5inrxcm 12 16 the the DT cord-352379-q5inrxcm 12 17 analogy analogy NN cord-352379-q5inrxcm 12 18 with with IN cord-352379-q5inrxcm 12 19 other other JJ cord-352379-q5inrxcm 12 20 coronaviruses coronaviruse NNS cord-352379-q5inrxcm 12 21 , , , cord-352379-q5inrxcm 12 22 several several JJ cord-352379-q5inrxcm 12 23 potential potential JJ cord-352379-q5inrxcm 12 24 targets target NNS cord-352379-q5inrxcm 12 25 for for IN cord-352379-q5inrxcm 12 26 antiviral antiviral JJ cord-352379-q5inrxcm 12 27 development development NN cord-352379-q5inrxcm 12 28 are be VBP cord-352379-q5inrxcm 12 29 identified identify VBN cord-352379-q5inrxcm 12 30 . . . cord-352379-q5inrxcm 13 1 Vaccines vaccine NNS cord-352379-q5inrxcm 13 2 offer offer VBP cord-352379-q5inrxcm 13 3 an an DT cord-352379-q5inrxcm 13 4 important important JJ cord-352379-q5inrxcm 13 5 preventive preventive JJ cord-352379-q5inrxcm 13 6 measure measure NN cord-352379-q5inrxcm 13 7 for for IN cord-352379-q5inrxcm 13 8 possible possible JJ cord-352379-q5inrxcm 13 9 future future JJ cord-352379-q5inrxcm 13 10 recurrences recurrence NNS cord-352379-q5inrxcm 13 11 of of IN cord-352379-q5inrxcm 13 12 SARS SARS NNP cord-352379-q5inrxcm 13 13 , , , cord-352379-q5inrxcm 13 14 but but CC cord-352379-q5inrxcm 13 15 the the DT cord-352379-q5inrxcm 13 16 prospect prospect NN cord-352379-q5inrxcm 13 17 for for IN cord-352379-q5inrxcm 13 18 their -PRON- PRP$ cord-352379-q5inrxcm 13 19 development development NN cord-352379-q5inrxcm 13 20 is be VBZ cord-352379-q5inrxcm 13 21 still still RB cord-352379-q5inrxcm 13 22 unknown unknown JJ cord-352379-q5inrxcm 13 23 because because IN cord-352379-q5inrxcm 13 24 of of IN cord-352379-q5inrxcm 13 25 the the DT cord-352379-q5inrxcm 13 26 uncertainty uncertainty NN cord-352379-q5inrxcm 13 27 regarding regard VBG cord-352379-q5inrxcm 13 28 the the DT cord-352379-q5inrxcm 13 29 role role NN cord-352379-q5inrxcm 13 30 of of IN cord-352379-q5inrxcm 13 31 immune immune JJ cord-352379-q5inrxcm 13 32 responses response NNS cord-352379-q5inrxcm 13 33 in in IN cord-352379-q5inrxcm 13 34 SARS SARS NNP cord-352379-q5inrxcm 13 35 virus virus NN cord-352379-q5inrxcm 13 36 pathogenesis pathogenesis NN cord-352379-q5inrxcm 13 37 . . . cord-352379-q5inrxcm 14 1 The the DT cord-352379-q5inrxcm 14 2 comparative comparative JJ cord-352379-q5inrxcm 14 3 studies study NNS cord-352379-q5inrxcm 14 4 of of IN cord-352379-q5inrxcm 14 5 other other JJ cord-352379-q5inrxcm 14 6 coronaviruses coronaviruse NNS cord-352379-q5inrxcm 14 7 offer offer VBP cord-352379-q5inrxcm 14 8 insights insight NNS cord-352379-q5inrxcm 14 9 into into IN cord-352379-q5inrxcm 14 10 the the DT cord-352379-q5inrxcm 14 11 understanding understanding NN cord-352379-q5inrxcm 14 12 of of IN cord-352379-q5inrxcm 14 13 SARS SARS NNP cord-352379-q5inrxcm 14 14 virus virus NN cord-352379-q5inrxcm 14 15 . . . cord-352379-q5inrxcm 15 1 Severe severe JJ cord-352379-q5inrxcm 15 2 acute acute JJ cord-352379-q5inrxcm 15 3 respiratory respiratory JJ cord-352379-q5inrxcm 15 4 syndrome syndrome NN cord-352379-q5inrxcm 15 5 ( ( -LRB- cord-352379-q5inrxcm 15 6 SARS SARS NNP cord-352379-q5inrxcm 15 7 ) ) -RRB- cord-352379-q5inrxcm 15 8 virus virus NN cord-352379-q5inrxcm 15 9 caused cause VBD cord-352379-q5inrxcm 15 10 a a DT cord-352379-q5inrxcm 15 11 severe severe JJ cord-352379-q5inrxcm 15 12 outbreak outbreak NN cord-352379-q5inrxcm 15 13 in in IN cord-352379-q5inrxcm 15 14 several several JJ cord-352379-q5inrxcm 15 15 regions region NNS cord-352379-q5inrxcm 15 16 of of IN cord-352379-q5inrxcm 15 17 the the DT cord-352379-q5inrxcm 15 18 world world NN cord-352379-q5inrxcm 15 19 in in IN cord-352379-q5inrxcm 15 20 2003 2003 CD cord-352379-q5inrxcm 15 21 . . . cord-352379-q5inrxcm 16 1 The the DT cord-352379-q5inrxcm 16 2 virus virus NN cord-352379-q5inrxcm 16 3 is be VBZ cord-352379-q5inrxcm 16 4 a a DT cord-352379-q5inrxcm 16 5 novel novel JJ cord-352379-q5inrxcm 16 6 coronavirus coronavirus NN cord-352379-q5inrxcm 16 7 , , , cord-352379-q5inrxcm 16 8 which which WDT cord-352379-q5inrxcm 16 9 may may MD cord-352379-q5inrxcm 16 10 have have VB cord-352379-q5inrxcm 16 11 an an DT cord-352379-q5inrxcm 16 12 origin origin NN cord-352379-q5inrxcm 16 13 in in IN cord-352379-q5inrxcm 16 14 wild wild JJ cord-352379-q5inrxcm 16 15 animals animal NNS cord-352379-q5inrxcm 16 16 such such JJ cord-352379-q5inrxcm 16 17 as as IN cord-352379-q5inrxcm 16 18 civet civet NN cord-352379-q5inrxcm 16 19 cats cat NNS cord-352379-q5inrxcm 16 20 in in IN cord-352379-q5inrxcm 16 21 southern southern JJ cord-352379-q5inrxcm 16 22 China China NNP cord-352379-q5inrxcm 16 23 . . . cord-352379-q5inrxcm 17 1 Its -PRON- PRP$ cord-352379-q5inrxcm 17 2 genome genome NN cord-352379-q5inrxcm 17 3 structure structure NN cord-352379-q5inrxcm 17 4 , , , cord-352379-q5inrxcm 17 5 gene gene NN cord-352379-q5inrxcm 17 6 expression expression NN cord-352379-q5inrxcm 17 7 pattern pattern NN cord-352379-q5inrxcm 17 8 and and CC cord-352379-q5inrxcm 17 9 protein protein NN cord-352379-q5inrxcm 17 10 profiles profile NNS cord-352379-q5inrxcm 17 11 are be VBP cord-352379-q5inrxcm 17 12 similar similar JJ cord-352379-q5inrxcm 17 13 to to IN cord-352379-q5inrxcm 17 14 those those DT cord-352379-q5inrxcm 17 15 of of IN cord-352379-q5inrxcm 17 16 other other JJ cord-352379-q5inrxcm 17 17 coronaviruses coronaviruse NNS cord-352379-q5inrxcm 17 18 . . . cord-352379-q5inrxcm 18 1 However however RB cord-352379-q5inrxcm 18 2 , , , cord-352379-q5inrxcm 18 3 distinct distinct JJ cord-352379-q5inrxcm 18 4 patterns pattern NNS cord-352379-q5inrxcm 18 5 of of IN cord-352379-q5inrxcm 18 6 several several JJ cord-352379-q5inrxcm 18 7 open open JJ cord-352379-q5inrxcm 18 8 reading reading NN cord-352379-q5inrxcm 18 9 frames frame NNS cord-352379-q5inrxcm 18 10 in in IN cord-352379-q5inrxcm 18 11 the the DT cord-352379-q5inrxcm 18 12 SARS SARS NNP cord-352379-q5inrxcm 18 13 virus virus NN cord-352379-q5inrxcm 18 14 genome genome NN cord-352379-q5inrxcm 18 15 may may MD cord-352379-q5inrxcm 18 16 contribute contribute VB cord-352379-q5inrxcm 18 17 to to IN cord-352379-q5inrxcm 18 18 its -PRON- PRP$ cord-352379-q5inrxcm 18 19 severe severe JJ cord-352379-q5inrxcm 18 20 virulence virulence NN cord-352379-q5inrxcm 18 21 . . . cord-352379-q5inrxcm 19 1 The the DT cord-352379-q5inrxcm 19 2 potential potential JJ cord-352379-q5inrxcm 19 3 mutability mutability NN cord-352379-q5inrxcm 19 4 of of IN cord-352379-q5inrxcm 19 5 the the DT cord-352379-q5inrxcm 19 6 coronavirus coronavirus NN cord-352379-q5inrxcm 19 7 genome genome NN cord-352379-q5inrxcm 19 8 may may MD cord-352379-q5inrxcm 19 9 pose pose VB cord-352379-q5inrxcm 19 10 problems problem NNS cord-352379-q5inrxcm 19 11 in in IN cord-352379-q5inrxcm 19 12 the the DT cord-352379-q5inrxcm 19 13 control control NN cord-352379-q5inrxcm 19 14 of of IN cord-352379-q5inrxcm 19 15 future future JJ cord-352379-q5inrxcm 19 16 SARS SARS NNP cord-352379-q5inrxcm 19 17 outbreaks outbreak NNS cord-352379-q5inrxcm 19 18 . . . cord-352379-q5inrxcm 20 1 The the DT cord-352379-q5inrxcm 20 2 mechanism mechanism NN cord-352379-q5inrxcm 20 3 of of IN cord-352379-q5inrxcm 20 4 SARS SARS NNP cord-352379-q5inrxcm 20 5 pathogenesis pathogenesis NN cord-352379-q5inrxcm 20 6 may may MD cord-352379-q5inrxcm 20 7 involve involve VB cord-352379-q5inrxcm 20 8 both both DT cord-352379-q5inrxcm 20 9 direct direct JJ cord-352379-q5inrxcm 20 10 viral viral JJ cord-352379-q5inrxcm 20 11 cytocidal cytocidal NN cord-352379-q5inrxcm 20 12 effects effect NNS cord-352379-q5inrxcm 20 13 on on IN cord-352379-q5inrxcm 20 14 the the DT cord-352379-q5inrxcm 20 15 target target NN cord-352379-q5inrxcm 20 16 cells cell NNS cord-352379-q5inrxcm 20 17 and and CC cord-352379-q5inrxcm 20 18 immune immune NN cord-352379-q5inrxcm 20 19 - - HYPH cord-352379-q5inrxcm 20 20 mediated mediate VBN cord-352379-q5inrxcm 20 21 mechanisms mechanism NNS cord-352379-q5inrxcm 20 22 . . . cord-352379-q5inrxcm 21 1 The the DT cord-352379-q5inrxcm 21 2 life life NN cord-352379-q5inrxcm 21 3 cycle cycle NN cord-352379-q5inrxcm 21 4 of of IN cord-352379-q5inrxcm 21 5 the the DT cord-352379-q5inrxcm 21 6 SARS SARS NNP cord-352379-q5inrxcm 21 7 virus virus NN cord-352379-q5inrxcm 21 8 is be VBZ cord-352379-q5inrxcm 21 9 largely largely RB cord-352379-q5inrxcm 21 10 unknown unknown JJ cord-352379-q5inrxcm 21 11 ; ; : cord-352379-q5inrxcm 21 12 however however RB cord-352379-q5inrxcm 21 13 , , , cord-352379-q5inrxcm 21 14 based base VBN cord-352379-q5inrxcm 21 15 on on IN cord-352379-q5inrxcm 21 16 the the DT cord-352379-q5inrxcm 21 17 analogy analogy NN cord-352379-q5inrxcm 21 18 with with IN cord-352379-q5inrxcm 21 19 other other JJ cord-352379-q5inrxcm 21 20 coronaviruses coronaviruse NNS cord-352379-q5inrxcm 21 21 , , , cord-352379-q5inrxcm 21 22 several several JJ cord-352379-q5inrxcm 21 23 potential potential JJ cord-352379-q5inrxcm 21 24 targets target NNS cord-352379-q5inrxcm 21 25 for for IN cord-352379-q5inrxcm 21 26 antiviral antiviral JJ cord-352379-q5inrxcm 21 27 development development NN cord-352379-q5inrxcm 21 28 are be VBP cord-352379-q5inrxcm 21 29 identified identify VBN cord-352379-q5inrxcm 21 30 . . . cord-352379-q5inrxcm 22 1 Vaccines vaccine NNS cord-352379-q5inrxcm 22 2 offer offer VBP cord-352379-q5inrxcm 22 3 an an DT cord-352379-q5inrxcm 22 4 important important JJ cord-352379-q5inrxcm 22 5 preventive preventive JJ cord-352379-q5inrxcm 22 6 measure measure NN cord-352379-q5inrxcm 22 7 for for IN cord-352379-q5inrxcm 22 8 possible possible JJ cord-352379-q5inrxcm 22 9 future future JJ cord-352379-q5inrxcm 22 10 recurrences recurrence NNS cord-352379-q5inrxcm 22 11 of of IN cord-352379-q5inrxcm 22 12 SARS SARS NNP cord-352379-q5inrxcm 22 13 , , , cord-352379-q5inrxcm 22 14 but but CC cord-352379-q5inrxcm 22 15 the the DT cord-352379-q5inrxcm 22 16 prospect prospect NN cord-352379-q5inrxcm 22 17 for for IN cord-352379-q5inrxcm 22 18 their -PRON- PRP$ cord-352379-q5inrxcm 22 19 development development NN cord-352379-q5inrxcm 22 20 is be VBZ cord-352379-q5inrxcm 22 21 still still RB cord-352379-q5inrxcm 22 22 unknown unknown JJ cord-352379-q5inrxcm 22 23 because because IN cord-352379-q5inrxcm 22 24 of of IN cord-352379-q5inrxcm 22 25 the the DT cord-352379-q5inrxcm 22 26 uncertainty uncertainty NN cord-352379-q5inrxcm 22 27 regarding regard VBG cord-352379-q5inrxcm 22 28 the the DT cord-352379-q5inrxcm 22 29 role role NN cord-352379-q5inrxcm 22 30 of of IN cord-352379-q5inrxcm 22 31 immune immune JJ cord-352379-q5inrxcm 22 32 responses response NNS cord-352379-q5inrxcm 22 33 in in IN cord-352379-q5inrxcm 22 34 SARS SARS NNP cord-352379-q5inrxcm 22 35 virus virus NN cord-352379-q5inrxcm 22 36 pathogenesis pathogenesis NN cord-352379-q5inrxcm 22 37 . . . cord-352379-q5inrxcm 23 1 The the DT cord-352379-q5inrxcm 23 2 comparative comparative JJ cord-352379-q5inrxcm 23 3 studies study NNS cord-352379-q5inrxcm 23 4 of of IN cord-352379-q5inrxcm 23 5 other other JJ cord-352379-q5inrxcm 23 6 coronaviruses coronaviruse NNS cord-352379-q5inrxcm 23 7 offer offer VBP cord-352379-q5inrxcm 23 8 insights insight NNS cord-352379-q5inrxcm 23 9 into into IN cord-352379-q5inrxcm 23 10 the the DT cord-352379-q5inrxcm 23 11 understanding understanding NN cord-352379-q5inrxcm 23 12 of of IN cord-352379-q5inrxcm 23 13 SARS SARS NNP cord-352379-q5inrxcm 23 14 virus virus NN cord-352379-q5inrxcm 23 15 . . . cord-352379-q5inrxcm 24 1 The the DT cord-352379-q5inrxcm 24 2 identification identification NN cord-352379-q5inrxcm 24 3 of of IN cord-352379-q5inrxcm 24 4 a a DT cord-352379-q5inrxcm 24 5 novel novel JJ cord-352379-q5inrxcm 24 6 coronavirus coronavirus NN cord-352379-q5inrxcm 24 7 as as IN cord-352379-q5inrxcm 24 8 the the DT cord-352379-q5inrxcm 24 9 etiological etiological JJ cord-352379-q5inrxcm 24 10 agent agent NN cord-352379-q5inrxcm 24 11 of of IN cord-352379-q5inrxcm 24 12 severe severe JJ cord-352379-q5inrxcm 24 13 acute acute JJ cord-352379-q5inrxcm 24 14 respiratory respiratory JJ cord-352379-q5inrxcm 24 15 syndrome syndrome NN cord-352379-q5inrxcm 24 16 ( ( -LRB- cord-352379-q5inrxcm 24 17 SARS SARS NNP cord-352379-q5inrxcm 24 18 ) ) -RRB- cord-352379-q5inrxcm 24 19 has have VBZ cord-352379-q5inrxcm 24 20 given give VBN cord-352379-q5inrxcm 24 21 an an DT cord-352379-q5inrxcm 24 22 impulse impulse NN cord-352379-q5inrxcm 24 23 to to TO cord-352379-q5inrxcm 24 24 research research VB cord-352379-q5inrxcm 24 25 on on IN cord-352379-q5inrxcm 24 26 the the DT cord-352379-q5inrxcm 24 27 coronavirus coronavirus NN cord-352379-q5inrxcm 24 28 family family NN cord-352379-q5inrxcm 24 29 , , , cord-352379-q5inrxcm 24 30 which which WDT cord-352379-q5inrxcm 24 31 has have VBZ cord-352379-q5inrxcm 24 32 long long RB cord-352379-q5inrxcm 24 33 been be VBN cord-352379-q5inrxcm 24 34 relegated relegate VBN cord-352379-q5inrxcm 24 35 to to IN cord-352379-q5inrxcm 24 36 the the DT cord-352379-q5inrxcm 24 37 status status NN cord-352379-q5inrxcm 24 38 of of IN cord-352379-q5inrxcm 24 39 a a DT cord-352379-q5inrxcm 24 40 scientifically scientifically RB cord-352379-q5inrxcm 24 41 interesting interesting JJ cord-352379-q5inrxcm 24 42 but but CC cord-352379-q5inrxcm 24 43 medically medically RB cord-352379-q5inrxcm 24 44 unimportant unimportant JJ cord-352379-q5inrxcm 24 45 virus virus NN cord-352379-q5inrxcm 24 46 family family NN cord-352379-q5inrxcm 24 47 . . . cord-352379-q5inrxcm 25 1 It -PRON- PRP cord-352379-q5inrxcm 25 2 is be VBZ cord-352379-q5inrxcm 25 3 not not RB cord-352379-q5inrxcm 25 4 that that IN cord-352379-q5inrxcm 25 5 coronavirus coronavirus NN cord-352379-q5inrxcm 25 6 has have VBZ cord-352379-q5inrxcm 25 7 never never RB cord-352379-q5inrxcm 25 8 been be VBN cord-352379-q5inrxcm 25 9 important important JJ cord-352379-q5inrxcm 25 10 ; ; : cord-352379-q5inrxcm 25 11 in in IN cord-352379-q5inrxcm 25 12 fact fact NN cord-352379-q5inrxcm 25 13 , , , cord-352379-q5inrxcm 25 14 coronavirus coronavirus NN cord-352379-q5inrxcm 25 15 infections infection NNS cord-352379-q5inrxcm 25 16 of of IN cord-352379-q5inrxcm 25 17 farm farm NN cord-352379-q5inrxcm 25 18 animals animal NNS cord-352379-q5inrxcm 25 19 , , , cord-352379-q5inrxcm 25 20 such such JJ cord-352379-q5inrxcm 25 21 as as IN cord-352379-q5inrxcm 25 22 pigs pig NNS cord-352379-q5inrxcm 25 23 or or CC cord-352379-q5inrxcm 25 24 chickens chicken NNS cord-352379-q5inrxcm 25 25 , , , cord-352379-q5inrxcm 25 26 are be VBP cord-352379-q5inrxcm 25 27 so so RB cord-352379-q5inrxcm 25 28 common common JJ cord-352379-q5inrxcm 25 29 and and CC cord-352379-q5inrxcm 25 30 devastating devastating JJ cord-352379-q5inrxcm 25 31 that that IN cord-352379-q5inrxcm 25 32 vaccinations vaccination NNS cord-352379-q5inrxcm 25 33 against against IN cord-352379-q5inrxcm 25 34 these these DT cord-352379-q5inrxcm 25 35 viruses virus NNS cord-352379-q5inrxcm 25 36 are be VBP cord-352379-q5inrxcm 25 37 routinely routinely RB cord-352379-q5inrxcm 25 38 performed perform VBN cord-352379-q5inrxcm 25 39 . . . cord-352379-q5inrxcm 26 1 In in IN cord-352379-q5inrxcm 26 2 humans human NNS cord-352379-q5inrxcm 26 3 , , , cord-352379-q5inrxcm 26 4 coronavirus coronavirus NN cord-352379-q5inrxcm 26 5 infections infection NNS cord-352379-q5inrxcm 26 6 are be VBP cord-352379-q5inrxcm 26 7 responsible responsible JJ cord-352379-q5inrxcm 26 8 for for IN cord-352379-q5inrxcm 26 9 almost almost RB cord-352379-q5inrxcm 26 10 200/0 200/0 CD cord-352379-q5inrxcm 26 11 of of IN cord-352379-q5inrxcm 26 12 common common JJ cord-352379-q5inrxcm 26 13 colds cold NNS cord-352379-q5inrxcm 26 14 in in IN cord-352379-q5inrxcm 26 15 wintertime wintertime NN cord-352379-q5inrxcm 26 16 [ [ -LRB- cord-352379-q5inrxcm 26 17 38 38 CD cord-352379-q5inrxcm 26 18 , , , cord-352379-q5inrxcm 26 19 57 57 CD cord-352379-q5inrxcm 26 20 ] ] -RRB- cord-352379-q5inrxcm 26 21 , , , cord-352379-q5inrxcm 26 22 and and CC cord-352379-q5inrxcm 26 23 the the DT cord-352379-q5inrxcm 26 24 virus virus NN cord-352379-q5inrxcm 26 25 has have VBZ cord-352379-q5inrxcm 26 26 been be VBN cord-352379-q5inrxcm 26 27 repeatedly repeatedly RB cord-352379-q5inrxcm 26 28 implicated implicate VBN cord-352379-q5inrxcm 26 29 , , , cord-352379-q5inrxcm 26 30 but but CC cord-352379-q5inrxcm 26 31 never never RB cord-352379-q5inrxcm 26 32 confirmed confirm VBD cord-352379-q5inrxcm 26 33 as as IN cord-352379-q5inrxcm 26 34 one one CD cord-352379-q5inrxcm 26 35 of of IN cord-352379-q5inrxcm 26 36 the the DT cord-352379-q5inrxcm 26 37 causative causative JJ cord-352379-q5inrxcm 26 38 agents agent NNS cord-352379-q5inrxcm 26 39 of of IN cord-352379-q5inrxcm 26 40 multiple multiple JJ cord-352379-q5inrxcm 26 41 sclerosis sclerosis NN cord-352379-q5inrxcm 26 42 [ [ -LRB- cord-352379-q5inrxcm 26 43 13 13 CD cord-352379-q5inrxcm 26 44 , , , cord-352379-q5inrxcm 26 45 71 71 CD cord-352379-q5inrxcm 26 46 ] ] -RRB- cord-352379-q5inrxcm 26 47 . . . cord-352379-q5inrxcm 27 1 Nevertheless nevertheless RB cord-352379-q5inrxcm 27 2 , , , cord-352379-q5inrxcm 27 3 the the DT cord-352379-q5inrxcm 27 4 lack lack NN cord-352379-q5inrxcm 27 5 of of IN cord-352379-q5inrxcm 27 6 a a DT cord-352379-q5inrxcm 27 7 firm firm JJ cord-352379-q5inrxcm 27 8 association association NN cord-352379-q5inrxcm 27 9 of of IN cord-352379-q5inrxcm 27 10 coronaviruses coronaviruse NNS cord-352379-q5inrxcm 27 11 with with IN cord-352379-q5inrxcm 27 12 any any DT cord-352379-q5inrxcm 27 13 serious serious JJ cord-352379-q5inrxcm 27 14 human human JJ cord-352379-q5inrxcm 27 15 illnesses illness NNS cord-352379-q5inrxcm 27 16 had have VBD cord-352379-q5inrxcm 27 17 dampened dampen VBN cord-352379-q5inrxcm 27 18 the the DT cord-352379-q5inrxcm 27 19 public public NN cord-352379-q5inrxcm 27 20 's 's POS cord-352379-q5inrxcm 27 21 interest interest NN cord-352379-q5inrxcm 27 22 in in IN cord-352379-q5inrxcm 27 23 this this DT cord-352379-q5inrxcm 27 24 virus virus NN cord-352379-q5inrxcm 27 25 family family NN cord-352379-q5inrxcm 27 26 until until IN cord-352379-q5inrxcm 27 27 the the DT cord-352379-q5inrxcm 27 28 sudden sudden JJ cord-352379-q5inrxcm 27 29 emergence emergence NN cord-352379-q5inrxcm 27 30 of of IN cord-352379-q5inrxcm 27 31 the the DT cord-352379-q5inrxcm 27 32 SARS SARS NNP cord-352379-q5inrxcm 27 33 coronavirus coronavirus NN cord-352379-q5inrxcm 27 34 [ [ -LRB- cord-352379-q5inrxcm 27 35 24 24 CD cord-352379-q5inrxcm 27 36 , , , cord-352379-q5inrxcm 27 37 41 41 CD cord-352379-q5inrxcm 27 38 , , , cord-352379-q5inrxcm 27 39 62 62 CD cord-352379-q5inrxcm 27 40 ] ] -RRB- cord-352379-q5inrxcm 27 41 , , , cord-352379-q5inrxcm 27 42 which which WDT cord-352379-q5inrxcm 27 43 caused cause VBD cord-352379-q5inrxcm 27 44 the the DT cord-352379-q5inrxcm 27 45 first first JJ cord-352379-q5inrxcm 27 46 new new JJ cord-352379-q5inrxcm 27 47 infectious infectious JJ cord-352379-q5inrxcm 27 48 disease disease NN cord-352379-q5inrxcm 27 49 of of IN cord-352379-q5inrxcm 27 50 this this DT cord-352379-q5inrxcm 27 51 millennium millennium NN cord-352379-q5inrxcm 27 52 . . . cord-352379-q5inrxcm 28 1 The the DT cord-352379-q5inrxcm 28 2 numerous numerous JJ cord-352379-q5inrxcm 28 3 past past JJ cord-352379-q5inrxcm 28 4 studies study NNS cord-352379-q5inrxcm 28 5 of of IN cord-352379-q5inrxcm 28 6 the the DT cord-352379-q5inrxcm 28 7 coronavirus coronavirus NN cord-352379-q5inrxcm 28 8 family family NN cord-352379-q5inrxcm 28 9 then then RB cord-352379-q5inrxcm 28 10 quickly quickly RB cord-352379-q5inrxcm 28 11 provided provide VBD cord-352379-q5inrxcm 28 12 a a DT cord-352379-q5inrxcm 28 13 blueprint blueprint NN cord-352379-q5inrxcm 28 14 for for IN cord-352379-q5inrxcm 28 15 understanding understand VBG cord-352379-q5inrxcm 28 16 the the DT cord-352379-q5inrxcm 28 17 SARS SARS NNP cord-352379-q5inrxcm 28 18 virus virus NN cord-352379-q5inrxcm 28 19 . . . cord-352379-q5inrxcm 29 1 However however RB cord-352379-q5inrxcm 29 2 , , , cord-352379-q5inrxcm 29 3 the the DT cord-352379-q5inrxcm 29 4 contagiousness contagiousness NN cord-352379-q5inrxcm 29 5 and and CC cord-352379-q5inrxcm 29 6 high high JJ cord-352379-q5inrxcm 29 7 mortality mortality NN cord-352379-q5inrxcm 29 8 rate rate NN cord-352379-q5inrxcm 29 9 of of IN cord-352379-q5inrxcm 29 10 the the DT cord-352379-q5inrxcm 29 11 SARS SARS NNP cord-352379-q5inrxcm 29 12 virus virus NN cord-352379-q5inrxcm 29 13 are be VBP cord-352379-q5inrxcm 29 14 unparalleled unparalleled JJ cord-352379-q5inrxcm 29 15 to to IN cord-352379-q5inrxcm 29 16 the the DT cord-352379-q5inrxcm 29 17 other other JJ cord-352379-q5inrxcm 29 18 known know VBN cord-352379-q5inrxcm 29 19 human human NN cord-352379-q5inrxcm 29 20 and and CC cord-352379-q5inrxcm 29 21 animal animal NN cord-352379-q5inrxcm 29 22 coronaviruses coronaviruse NNS cord-352379-q5inrxcm 29 23 ; ; : cord-352379-q5inrxcm 29 24 thus thus RB cord-352379-q5inrxcm 29 25 , , , cord-352379-q5inrxcm 29 26 SARS SARS NNP cord-352379-q5inrxcm 29 27 coronavirus coronavirus NN cord-352379-q5inrxcm 29 28 is be VBZ cord-352379-q5inrxcm 29 29 unique unique JJ cord-352379-q5inrxcm 29 30 in in IN cord-352379-q5inrxcm 29 31 multiple multiple JJ cord-352379-q5inrxcm 29 32 ways way NNS cord-352379-q5inrxcm 29 33 . . . cord-352379-q5inrxcm 30 1 The the DT cord-352379-q5inrxcm 30 2 understanding understanding NN cord-352379-q5inrxcm 30 3 of of IN cord-352379-q5inrxcm 30 4 this this DT cord-352379-q5inrxcm 30 5 virus virus NN cord-352379-q5inrxcm 30 6 , , , cord-352379-q5inrxcm 30 7 including include VBG cord-352379-q5inrxcm 30 8 its -PRON- PRP$ cord-352379-q5inrxcm 30 9 origin origin NN cord-352379-q5inrxcm 30 10 , , , cord-352379-q5inrxcm 30 11 molecular molecular JJ cord-352379-q5inrxcm 30 12 properties property NNS cord-352379-q5inrxcm 30 13 and and CC cord-352379-q5inrxcm 30 14 pathogenesis pathogenesis NN cord-352379-q5inrxcm 30 15 , , , cord-352379-q5inrxcm 30 16 will will MD cord-352379-q5inrxcm 30 17 be be VB cord-352379-q5inrxcm 30 18 crucial crucial JJ cord-352379-q5inrxcm 30 19 for for IN cord-352379-q5inrxcm 30 20 the the DT cord-352379-q5inrxcm 30 21 future future JJ cord-352379-q5inrxcm 30 22 management management NN cord-352379-q5inrxcm 30 23 of of IN cord-352379-q5inrxcm 30 24 this this DT cord-352379-q5inrxcm 30 25 infectious infectious JJ cord-352379-q5inrxcm 30 26 disease disease NN cord-352379-q5inrxcm 30 27 . . . cord-352379-q5inrxcm 31 1 Since since IN cord-352379-q5inrxcm 31 2 the the DT cord-352379-q5inrxcm 31 3 studies study NNS cord-352379-q5inrxcm 31 4 on on IN cord-352379-q5inrxcm 31 5 the the DT cord-352379-q5inrxcm 31 6 SARS SARS NNP cord-352379-q5inrxcm 31 7 virus virus NN cord-352379-q5inrxcm 31 8 are be VBP cord-352379-q5inrxcm 31 9 very very RB cord-352379-q5inrxcm 31 10 limited limited JJ cord-352379-q5inrxcm 31 11 so so RB cord-352379-q5inrxcm 31 12 far far RB cord-352379-q5inrxcm 31 13 , , , cord-352379-q5inrxcm 31 14 this this DT cord-352379-q5inrxcm 31 15 review review NN cord-352379-q5inrxcm 31 16 aimed aim VBN cord-352379-q5inrxcm 31 17 at at IN cord-352379-q5inrxcm 31 18 investigating investigate VBG cord-352379-q5inrxcm 31 19 the the DT cord-352379-q5inrxcm 31 20 possible possible JJ cord-352379-q5inrxcm 31 21 properties property NNS cord-352379-q5inrxcm 31 22 of of IN cord-352379-q5inrxcm 31 23 the the DT cord-352379-q5inrxcm 31 24 virus virus NN cord-352379-q5inrxcm 31 25 based base VBN cord-352379-q5inrxcm 31 26 primarily primarily RB cord-352379-q5inrxcm 31 27 on on IN cord-352379-q5inrxcm 31 28 comparative comparative JJ cord-352379-q5inrxcm 31 29 studies study NNS cord-352379-q5inrxcm 31 30 of of IN cord-352379-q5inrxcm 31 31 other other JJ cord-352379-q5inrxcm 31 32 coronaviruses coronaviruse NNS cord-352379-q5inrxcm 31 33 . . . cord-352379-q5inrxcm 32 1 Coronaviruses coronaviruse NNS cord-352379-q5inrxcm 32 2 are be VBP cord-352379-q5inrxcm 32 3 divided divide VBN cord-352379-q5inrxcm 32 4 into into IN cord-352379-q5inrxcm 32 5 three three CD cord-352379-q5inrxcm 32 6 antigenically antigenically RB cord-352379-q5inrxcm 32 7 distinct distinct JJ cord-352379-q5inrxcm 32 8 groups group NNS cord-352379-q5inrxcm 32 9 , , , cord-352379-q5inrxcm 32 10 which which WDT cord-352379-q5inrxcm 32 11 are be VBP cord-352379-q5inrxcm 32 12 also also RB cord-352379-q5inrxcm 32 13 consistent consistent JJ cord-352379-q5inrxcm 32 14 with with IN cord-352379-q5inrxcm 32 15 the the DT cord-352379-q5inrxcm 32 16 genetic genetic JJ cord-352379-q5inrxcm 32 17 relatedness relatedness NN cord-352379-q5inrxcm 32 18 of of IN cord-352379-q5inrxcm 32 19 these these DT cord-352379-q5inrxcm 32 20 viruses virus NNS cord-352379-q5inrxcm 32 21 [ [ -LRB- cord-352379-q5inrxcm 32 22 49 49 CD cord-352379-q5inrxcm 32 23 ] ] -RRB- cord-352379-q5inrxcm 32 24 . . . cord-352379-q5inrxcm 33 1 Group group NN cord-352379-q5inrxcm 33 2 I -PRON- PRP cord-352379-q5inrxcm 33 3 consists consist VBZ cord-352379-q5inrxcm 33 4 of of IN cord-352379-q5inrxcm 33 5 human human JJ cord-352379-q5inrxcm 33 6 coronavirus coronavirus NN cord-352379-q5inrxcm 33 7 229E 229e CD cord-352379-q5inrxcm 33 8 ( ( -LRB- cord-352379-q5inrxcm 33 9 HCoV-229E HCoV-229E NNP cord-352379-q5inrxcm 33 10 ) ) -RRB- cord-352379-q5inrxcm 33 11 , , , cord-352379-q5inrxcm 33 12 porcine porcine JJ cord-352379-q5inrxcm 33 13 transmissible transmissible JJ cord-352379-q5inrxcm 33 14 gastroentefitis gastroentefitis NN cord-352379-q5inrxcm 33 15 virus virus NN cord-352379-q5inrxcm 33 16 ( ( -LRB- cord-352379-q5inrxcm 33 17 TGEV TGEV NNP cord-352379-q5inrxcm 33 18 ) ) -RRB- cord-352379-q5inrxcm 33 19 , , , cord-352379-q5inrxcm 33 20 porcine porcine JJ cord-352379-q5inrxcm 33 21 respiratory respiratory JJ cord-352379-q5inrxcm 33 22 coronavirus coronavirus NN cord-352379-q5inrxcm 33 23 ( ( -LRB- cord-352379-q5inrxcm 33 24 PRCV PRCV NNP cord-352379-q5inrxcm 33 25 ) ) -RRB- cord-352379-q5inrxcm 33 26 , , , cord-352379-q5inrxcm 33 27 feline feline JJ cord-352379-q5inrxcm 33 28 infectious infectious JJ cord-352379-q5inrxcm 33 29 peritonitis peritonitis NN cord-352379-q5inrxcm 33 30 virus virus NN cord-352379-q5inrxcm 33 31 ( ( -LRB- cord-352379-q5inrxcm 33 32 FIPV FIPV NNP cord-352379-q5inrxcm 33 33 ) ) -RRB- cord-352379-q5inrxcm 33 34 and and CC cord-352379-q5inrxcm 33 35 enteritis enteritis NN cord-352379-q5inrxcm 33 36 virus virus NN cord-352379-q5inrxcm 33 37 ( ( -LRB- cord-352379-q5inrxcm 33 38 FECoV fecov NN cord-352379-q5inrxcm 33 39 ) ) -RRB- cord-352379-q5inrxcm 33 40 , , , cord-352379-q5inrxcm 33 41 canine canine JJ cord-352379-q5inrxcm 33 42 coronavirus coronavirus NN cord-352379-q5inrxcm 33 43 ( ( -LRB- cord-352379-q5inrxcm 33 44 CCoV ccov ADD cord-352379-q5inrxcm 33 45 ) ) -RRB- cord-352379-q5inrxcm 33 46 and and CC cord-352379-q5inrxcm 33 47 others other NNS cord-352379-q5inrxcm 33 48 . . . cord-352379-q5inrxcm 34 1 Group Group NNP cord-352379-q5inrxcm 34 2 II II NNP cord-352379-q5inrxcm 34 3 consists consist VBZ cord-352379-q5inrxcm 34 4 of of IN cord-352379-q5inrxcm 34 5 human human JJ cord-352379-q5inrxcm 34 6 coronavirus coronavirus NN cord-352379-q5inrxcm 34 7 OC43 OC43 NNP cord-352379-q5inrxcm 34 8 ( ( -LRB- cord-352379-q5inrxcm 34 9 HCoV HCoV NNP cord-352379-q5inrxcm 34 10 - - HYPH cord-352379-q5inrxcm 34 11 OC43 OC43 NNP cord-352379-q5inrxcm 34 12 ) ) -RRB- cord-352379-q5inrxcm 34 13 , , , cord-352379-q5inrxcm 34 14 mouse mouse NNP cord-352379-q5inrxcm 34 15 hepatitis hepatitis NN cord-352379-q5inrxcm 34 16 virus virus NN cord-352379-q5inrxcm 34 17 ( ( -LRB- cord-352379-q5inrxcm 34 18 MHV MHV NNP cord-352379-q5inrxcm 34 19 ) ) -RRB- cord-352379-q5inrxcm 34 20 , , , cord-352379-q5inrxcm 34 21 bovine bovine JJ cord-352379-q5inrxcm 34 22 coronavirus coronavirus NN cord-352379-q5inrxcm 34 23 ( ( -LRB- cord-352379-q5inrxcm 34 24 BCoV BCoV NNP cord-352379-q5inrxcm 34 25 ) ) -RRB- cord-352379-q5inrxcm 34 26 and and CC cord-352379-q5inrxcm 34 27 others other NNS cord-352379-q5inrxcm 34 28 . . . cord-352379-q5inrxcm 35 1 Group Group NNP cord-352379-q5inrxcm 35 2 III III NNP cord-352379-q5inrxcm 35 3 consists consist VBZ cord-352379-q5inrxcm 35 4 of of IN cord-352379-q5inrxcm 35 5 avian avian JJ cord-352379-q5inrxcm 35 6 species specie NNS cord-352379-q5inrxcm 35 7 , , , cord-352379-q5inrxcm 35 8 including include VBG cord-352379-q5inrxcm 35 9 chicken chicken NN cord-352379-q5inrxcm 35 10 infectious infectious JJ cord-352379-q5inrxcm 35 11 bronchitis bronchitis NN cord-352379-q5inrxcm 35 12 virus virus NN cord-352379-q5inrxcm 35 13 ( ( -LRB- cord-352379-q5inrxcm 35 14 IB¥ IB¥ NNP cord-352379-q5inrxcm 35 15 ) ) -RRB- cord-352379-q5inrxcm 35 16 and and CC cord-352379-q5inrxcm 35 17 turkey turkey NNP cord-352379-q5inrxcm 35 18 coronavirus coronavirus NN cord-352379-q5inrxcm 35 19 ( ( -LRB- cord-352379-q5inrxcm 35 20 TCoV TCoV NNP cord-352379-q5inrxcm 35 21 ) ) -RRB- cord-352379-q5inrxcm 35 22 . . . cord-352379-q5inrxcm 36 1 The the DT cord-352379-q5inrxcm 36 2 newly newly RB cord-352379-q5inrxcm 36 3 discovered discover VBN cord-352379-q5inrxcm 36 4 SARS SARS NNP cord-352379-q5inrxcm 36 5 virus virus NN cord-352379-q5inrxcm 36 6 cross cross NN cord-352379-q5inrxcm 36 7 - - VBZ cord-352379-q5inrxcm 36 8 reacts react VBZ cord-352379-q5inrxcm 36 9 with with IN cord-352379-q5inrxcm 36 10 antibodies antibody NNS cord-352379-q5inrxcm 36 11 of of IN cord-352379-q5inrxcm 36 12 group group NN cord-352379-q5inrxcm 36 13 I -PRON- PRP cord-352379-q5inrxcm 36 14 coronaviruses coronaviruse VBZ cord-352379-q5inrxcm 36 15 [ [ -LRB- cord-352379-q5inrxcm 36 16 41 41 CD cord-352379-q5inrxcm 36 17 ] ] -RRB- cord-352379-q5inrxcm 36 18 . . . cord-352379-q5inrxcm 37 1 However however RB cord-352379-q5inrxcm 37 2 , , , cord-352379-q5inrxcm 37 3 its -PRON- PRP$ cord-352379-q5inrxcm 37 4 genetic genetic JJ cord-352379-q5inrxcm 37 5 sequence sequence NN cord-352379-q5inrxcm 37 6 indicates indicate VBZ cord-352379-q5inrxcm 37 7 that that IN cord-352379-q5inrxcm 37 8 it -PRON- PRP cord-352379-q5inrxcm 37 9 belongs belong VBZ cord-352379-q5inrxcm 37 10 to to IN cord-352379-q5inrxcm 37 11 none none NN cord-352379-q5inrxcm 37 12 of of IN cord-352379-q5inrxcm 37 13 these these DT cord-352379-q5inrxcm 37 14 three three CD cord-352379-q5inrxcm 37 15 groups group NNS cord-352379-q5inrxcm 37 16 . . . cord-352379-q5inrxcm 38 1 It -PRON- PRP cord-352379-q5inrxcm 38 2 is be VBZ cord-352379-q5inrxcm 38 3 of of IN cord-352379-q5inrxcm 38 4 about about IN cord-352379-q5inrxcm 38 5 equal equal JJ cord-352379-q5inrxcm 38 6 distance distance NN cord-352379-q5inrxcm 38 7 from from IN cord-352379-q5inrxcm 38 8 both both DT cord-352379-q5inrxcm 38 9 groups group NNS cord-352379-q5inrxcm 38 10 II II NNP cord-352379-q5inrxcm 38 11 and and CC cord-352379-q5inrxcm 38 12 III III NNP cord-352379-q5inrxcm 38 13 in in IN cord-352379-q5inrxcm 38 14 the the DT cord-352379-q5inrxcm 38 15 coronavirus coronavirus NN cord-352379-q5inrxcm 38 16 family family NN cord-352379-q5inrxcm 38 17 phylogenetic phylogenetic NN cord-352379-q5inrxcm 38 18 tree tree NN cord-352379-q5inrxcm 38 19 in in IN cord-352379-q5inrxcm 38 20 nucleic nucleic JJ cord-352379-q5inrxcm 38 21 acid acid NN cord-352379-q5inrxcm 38 22 or or CC cord-352379-q5inrxcm 38 23 protein protein NN cord-352379-q5inrxcm 38 24 sequence sequence NN cord-352379-q5inrxcm 38 25 [ [ -LRB- cord-352379-q5inrxcm 38 26 41 41 CD cord-352379-q5inrxcm 38 27 , , , cord-352379-q5inrxcm 38 28 55 55 CD cord-352379-q5inrxcm 38 29 , , , cord-352379-q5inrxcm 38 30 66 66 CD cord-352379-q5inrxcm 38 31 ] ] -RRB- cord-352379-q5inrxcm 38 32 . . . cord-352379-q5inrxcm 39 1 A a DT cord-352379-q5inrxcm 39 2 similar similar JJ cord-352379-q5inrxcm 39 3 conclusion conclusion NN cord-352379-q5inrxcm 39 4 is be VBZ cord-352379-q5inrxcm 39 5 reached reach VBN cord-352379-q5inrxcm 39 6 irrespective irrespective RB cord-352379-q5inrxcm 39 7 of of IN cord-352379-q5inrxcm 39 8 which which WDT cord-352379-q5inrxcm 39 9 viral viral JJ cord-352379-q5inrxcm 39 10 RNA RNA NNP cord-352379-q5inrxcm 39 11 region region NN cord-352379-q5inrxcm 39 12 is be VBZ cord-352379-q5inrxcm 39 13 used use VBN cord-352379-q5inrxcm 39 14 for for IN cord-352379-q5inrxcm 39 15 comparison comparison NN cord-352379-q5inrxcm 39 16 . . . cord-352379-q5inrxcm 40 1 Thus thus RB cord-352379-q5inrxcm 40 2 , , , cord-352379-q5inrxcm 40 3 SARS SARS NNP cord-352379-q5inrxcm 40 4 virus virus NN cord-352379-q5inrxcm 40 5 represents represent VBZ cord-352379-q5inrxcm 40 6 a a DT cord-352379-q5inrxcm 40 7 new new JJ cord-352379-q5inrxcm 40 8 group group NN cord-352379-q5inrxcm 40 9 of of IN cord-352379-q5inrxcm 40 10 coronavirus coronavirus NN cord-352379-q5inrxcm 40 11 . . . cord-352379-q5inrxcm 41 1 Although although IN cord-352379-q5inrxcm 41 2 this this DT cord-352379-q5inrxcm 41 3 virus virus NN cord-352379-q5inrxcm 41 4 most most RBS cord-352379-q5inrxcm 41 5 likely likely RB cord-352379-q5inrxcm 41 6 originated originate VBD cord-352379-q5inrxcm 41 7 from from IN cord-352379-q5inrxcm 41 8 a a DT cord-352379-q5inrxcm 41 9 wild wild JJ cord-352379-q5inrxcm 41 10 animal animal NN cord-352379-q5inrxcm 41 11 ( ( -LRB- cord-352379-q5inrxcm 41 12 see see VB cord-352379-q5inrxcm 41 13 next next JJ cord-352379-q5inrxcm 41 14 section section NN cord-352379-q5inrxcm 41 15 ) ) -RRB- cord-352379-q5inrxcm 41 16 , , , cord-352379-q5inrxcm 41 17 the the DT cord-352379-q5inrxcm 41 18 SARS SARS NNP cord-352379-q5inrxcm 41 19 virus virus NN cord-352379-q5inrxcm 41 20 has have VBZ cord-352379-q5inrxcm 41 21 been be VBN cord-352379-q5inrxcm 41 22 well well RB cord-352379-q5inrxcm 41 23 adapted adapt VBN cord-352379-q5inrxcm 41 24 in in IN cord-352379-q5inrxcm 41 25 humans human NNS cord-352379-q5inrxcm 41 26 , , , cord-352379-q5inrxcm 41 27 as as IN cord-352379-q5inrxcm 41 28 evidenced evidence VBN cord-352379-q5inrxcm 41 29 by by IN cord-352379-q5inrxcm 41 30 the the DT cord-352379-q5inrxcm 41 31 high high JJ cord-352379-q5inrxcm 41 32 person person NN cord-352379-q5inrxcm 41 33 - - HYPH cord-352379-q5inrxcm 41 34 to to IN cord-352379-q5inrxcm 41 35 - - HYPH cord-352379-q5inrxcm 41 36 person person NN cord-352379-q5inrxcm 41 37 transmissibitity transmissibitity NN cord-352379-q5inrxcm 41 38 of of IN cord-352379-q5inrxcm 41 39 the the DT cord-352379-q5inrxcm 41 40 virus virus NN cord-352379-q5inrxcm 41 41 . . . cord-352379-q5inrxcm 42 1 Thus thus RB cord-352379-q5inrxcm 42 2 , , , cord-352379-q5inrxcm 42 3 it -PRON- PRP cord-352379-q5inrxcm 42 4 is be VBZ cord-352379-q5inrxcm 42 5 most most RBS cord-352379-q5inrxcm 42 6 appropriately appropriately RB cord-352379-q5inrxcm 42 7 named name VBN cord-352379-q5inrxcm 42 8 human human JJ cord-352379-q5inrxcm 42 9 coronavirus coronavirus NN cord-352379-q5inrxcm 42 10 SARS SARS NNP cord-352379-q5inrxcm 42 11 strain strain NN cord-352379-q5inrxcm 42 12 . . . cord-352379-q5inrxcm 43 1 However however RB cord-352379-q5inrxcm 43 2 , , , cord-352379-q5inrxcm 43 3 its -PRON- PRP$ cord-352379-q5inrxcm 43 4 official official JJ cord-352379-q5inrxcm 43 5 taxonomic taxonomic JJ cord-352379-q5inrxcm 43 6 status status NN cord-352379-q5inrxcm 43 7 remains remain VBZ cord-352379-q5inrxcm 43 8 to to TO cord-352379-q5inrxcm 43 9 be be VB cord-352379-q5inrxcm 43 10 decided decide VBN cord-352379-q5inrxcm 43 11 . . . cord-352379-q5inrxcm 44 1 Since since IN cord-352379-q5inrxcm 44 2 the the DT cord-352379-q5inrxcm 44 3 first first JJ cord-352379-q5inrxcm 44 4 reported reported JJ cord-352379-q5inrxcm 44 5 occurrence occurrence NN cord-352379-q5inrxcm 44 6 of of IN cord-352379-q5inrxcm 44 7 SARS SARS NNP cord-352379-q5inrxcm 44 8 in in IN cord-352379-q5inrxcm 44 9 southern southern JJ cord-352379-q5inrxcm 44 10 China China NNP cord-352379-q5inrxcm 44 11 , , , cord-352379-q5inrxcm 44 12 speculation speculation NN cord-352379-q5inrxcm 44 13 on on IN cord-352379-q5inrxcm 44 14 the the DT cord-352379-q5inrxcm 44 15 origin origin NN cord-352379-q5inrxcm 44 16 of of IN cord-352379-q5inrxcm 44 17 SARS SARS NNP cord-352379-q5inrxcm 44 18 virus virus NN cord-352379-q5inrxcm 44 19 has have VBZ cord-352379-q5inrxcm 44 20 largely largely RB cord-352379-q5inrxcm 44 21 focused focus VBN cord-352379-q5inrxcm 44 22 on on IN cord-352379-q5inrxcm 44 23 the the DT cord-352379-q5inrxcm 44 24 animal animal NN cord-352379-q5inrxcm 44 25 species specie NNS cord-352379-q5inrxcm 44 26 in in IN cord-352379-q5inrxcm 44 27 that that DT cord-352379-q5inrxcm 44 28 region region NN cord-352379-q5inrxcm 44 29 . . . cord-352379-q5inrxcm 45 1 Because because IN cord-352379-q5inrxcm 45 2 the the DT cord-352379-q5inrxcm 45 3 genetic genetic JJ cord-352379-q5inrxcm 45 4 sequence sequence NN cord-352379-q5inrxcm 45 5 of of IN cord-352379-q5inrxcm 45 6 SARS SARS NNP cord-352379-q5inrxcm 45 7 virus virus NN cord-352379-q5inrxcm 45 8 is be VBZ cord-352379-q5inrxcm 45 9 distinct distinct JJ cord-352379-q5inrxcm 45 10 and and CC cord-352379-q5inrxcm 45 11 distant distant JJ cord-352379-q5inrxcm 45 12 from from IN cord-352379-q5inrxcm 45 13 that that DT cord-352379-q5inrxcm 45 14 of of IN cord-352379-q5inrxcm 45 15 any any DT cord-352379-q5inrxcm 45 16 known know VBN cord-352379-q5inrxcm 45 17 coronaviruses coronaviruse NNS cord-352379-q5inrxcm 45 18 in in IN cord-352379-q5inrxcm 45 19 domestic domestic JJ cord-352379-q5inrxcm 45 20 animals animal NNS cord-352379-q5inrxcm 45 21 , , , cord-352379-q5inrxcm 45 22 the the DT cord-352379-q5inrxcm 45 23 SARS SARS NNP cord-352379-q5inrxcm 45 24 virus virus NN cord-352379-q5inrxcm 45 25 most most RBS cord-352379-q5inrxcm 45 26 likely likely RB cord-352379-q5inrxcm 45 27 originated originate VBD cord-352379-q5inrxcm 45 28 from from IN cord-352379-q5inrxcm 45 29 a a DT cord-352379-q5inrxcm 45 30 wild wild JJ cord-352379-q5inrxcm 45 31 animal animal NN cord-352379-q5inrxcm 45 32 . . . cord-352379-q5inrxcm 46 1 The the DT cord-352379-q5inrxcm 46 2 search search NN cord-352379-q5inrxcm 46 3 for for IN cord-352379-q5inrxcm 46 4 coronaviruses coronaviruse NNS cord-352379-q5inrxcm 46 5 in in IN cord-352379-q5inrxcm 46 6 wild wild JJ cord-352379-q5inrxcm 46 7 animals animal NNS cord-352379-q5inrxcm 46 8 eventually eventually RB cord-352379-q5inrxcm 46 9 turned turn VBD cord-352379-q5inrxcm 46 10 up up RP cord-352379-q5inrxcm 46 11 a a DT cord-352379-q5inrxcm 46 12 coronavirus coronavirus NN cord-352379-q5inrxcm 46 13 in in IN cord-352379-q5inrxcm 46 14 civet civet NN cord-352379-q5inrxcm 46 15 cats cat NNS cord-352379-q5inrxcm 46 16 in in IN cord-352379-q5inrxcm 46 17 a a DT cord-352379-q5inrxcm 46 18 market market NN cord-352379-q5inrxcm 46 19 in in IN cord-352379-q5inrxcm 46 20 Guangdong Guangdong NNP cord-352379-q5inrxcm 46 21 province province NN cord-352379-q5inrxcm 46 22 . . . cord-352379-q5inrxcm 47 1 The the DT cord-352379-q5inrxcm 47 2 civet civet NN cord-352379-q5inrxcm 47 3 cat cat NN cord-352379-q5inrxcm 47 4 coronavirus coronavirus NN cord-352379-q5inrxcm 47 5 is be VBZ cord-352379-q5inrxcm 47 6 very very RB cord-352379-q5inrxcm 47 7 closely closely RB cord-352379-q5inrxcm 47 8 related related JJ cord-352379-q5inrxcm 47 9 to to IN cord-352379-q5inrxcm 47 10 the the DT cord-352379-q5inrxcm 47 11 SARS SARS NNP cord-352379-q5inrxcm 47 12 virus virus NN cord-352379-q5inrxcm 47 13 , , , cord-352379-q5inrxcm 47 14 with with IN cord-352379-q5inrxcm 47 15 more more JJR cord-352379-q5inrxcm 47 16 than than IN cord-352379-q5inrxcm 47 17 99 99 CD cord-352379-q5inrxcm 47 18 % % NN cord-352379-q5inrxcm 47 19 sequence sequence NN cord-352379-q5inrxcm 47 20 homology homology NN cord-352379-q5inrxcm 47 21 [ [ -LRB- cord-352379-q5inrxcm 47 22 1 1 CD cord-352379-q5inrxcm 47 23 , , , cord-352379-q5inrxcm 47 24 30a 30a NNS cord-352379-q5inrxcm 47 25 , , , cord-352379-q5inrxcm 47 26 60 60 CD cord-352379-q5inrxcm 47 27 ] ] -RRB- cord-352379-q5inrxcm 47 28 . . . cord-352379-q5inrxcm 48 1 Recent recent JJ cord-352379-q5inrxcm 48 2 reports report NNS cord-352379-q5inrxcm 48 3 indicate indicate VBP cord-352379-q5inrxcm 48 4 that that IN cord-352379-q5inrxcm 48 5 SARS SARS NNP cord-352379-q5inrxcm 48 6 virus virus NN cord-352379-q5inrxcm 48 7 is be VBZ cord-352379-q5inrxcm 48 8 distinct distinct JJ cord-352379-q5inrxcm 48 9 from from IN cord-352379-q5inrxcm 48 10 the the DT cord-352379-q5inrxcm 48 11 civet civet NN cord-352379-q5inrxcm 48 12 cat cat NN cord-352379-q5inrxcm 48 13 virus virus NN cord-352379-q5inrxcm 48 14 by by IN cord-352379-q5inrxcm 48 15 limited limited JJ cord-352379-q5inrxcm 48 16 deletions deletion NNS cord-352379-q5inrxcm 48 17 and and CC cord-352379-q5inrxcm 48 18 mutations mutation NNS cord-352379-q5inrxcm 48 19 . . . cord-352379-q5inrxcm 49 1 The the DT cord-352379-q5inrxcm 49 2 extent extent NN cord-352379-q5inrxcm 49 3 of of IN cord-352379-q5inrxcm 49 4 the the DT cord-352379-q5inrxcm 49 5 coronavirus coronavirus NN cord-352379-q5inrxcm 49 6 infection infection NN cord-352379-q5inrxcm 49 7 among among IN cord-352379-q5inrxcm 49 8 wild wild JJ cord-352379-q5inrxcm 49 9 animals animal NNS cord-352379-q5inrxcm 49 10 is be VBZ cord-352379-q5inrxcm 49 11 not not RB cord-352379-q5inrxcm 49 12 yet yet RB cord-352379-q5inrxcm 49 13 clear clear JJ cord-352379-q5inrxcm 49 14 [ [ -LRB- cord-352379-q5inrxcm 49 15 30a 30a NN cord-352379-q5inrxcm 49 16 ] ] -RRB- cord-352379-q5inrxcm 49 17 . . . cord-352379-q5inrxcm 50 1 The the DT cord-352379-q5inrxcm 50 2 animal animal NN cord-352379-q5inrxcm 50 3 handlers handler NNS cord-352379-q5inrxcm 50 4 appear appear VBP cord-352379-q5inrxcm 50 5 to to TO cord-352379-q5inrxcm 50 6 be be VB cord-352379-q5inrxcm 50 7 at at IN cord-352379-q5inrxcm 50 8 risk risk NN cord-352379-q5inrxcm 50 9 for for IN cord-352379-q5inrxcm 50 10 the the DT cord-352379-q5inrxcm 50 11 infection infection NN cord-352379-q5inrxcm 50 12 as as IN cord-352379-q5inrxcm 50 13 a a DT cord-352379-q5inrxcm 50 14 higher high JJR cord-352379-q5inrxcm 50 15 proportion proportion NN cord-352379-q5inrxcm 50 16 of of IN cord-352379-q5inrxcm 50 17 them -PRON- PRP cord-352379-q5inrxcm 50 18 have have VBP cord-352379-q5inrxcm 50 19 antibodies antibody NNS cord-352379-q5inrxcm 50 20 against against IN cord-352379-q5inrxcm 50 21 SARS SARS NNP cord-352379-q5inrxcm 50 22 virus virus NN cord-352379-q5inrxcm 50 23 [ [ -LRB- cord-352379-q5inrxcm 50 24 30a 30a NN cord-352379-q5inrxcm 50 25 ] ] -RRB- cord-352379-q5inrxcm 50 26 . . . cord-352379-q5inrxcm 51 1 However however RB cord-352379-q5inrxcm 51 2 , , , cord-352379-q5inrxcm 51 3 none none NN cord-352379-q5inrxcm 51 4 of of IN cord-352379-q5inrxcm 51 5 these these DT cord-352379-q5inrxcm 51 6 data datum NNS cord-352379-q5inrxcm 51 7 have have VBP cord-352379-q5inrxcm 51 8 so so RB cord-352379-q5inrxcm 51 9 far far RB cord-352379-q5inrxcm 51 10 been be VBN cord-352379-q5inrxcm 51 11 confirmed confirm VBN cord-352379-q5inrxcm 51 12 . . . cord-352379-q5inrxcm 52 1 Although although IN cord-352379-q5inrxcm 52 2 plausible plausible JJ cord-352379-q5inrxcm 52 3 , , , cord-352379-q5inrxcm 52 4 the the DT cord-352379-q5inrxcm 52 5 civet civet NN cord-352379-q5inrxcm 52 6 cat cat NN cord-352379-q5inrxcm 52 7 virus virus NN cord-352379-q5inrxcm 52 8 as as IN cord-352379-q5inrxcm 52 9 the the DT cord-352379-q5inrxcm 52 10 origin origin NN cord-352379-q5inrxcm 52 11 of of IN cord-352379-q5inrxcm 52 12 SARS SARS NNP cord-352379-q5inrxcm 52 13 virus virus NN cord-352379-q5inrxcm 52 14 remains remain VBZ cord-352379-q5inrxcm 52 15 to to TO cord-352379-q5inrxcm 52 16 be be VB cord-352379-q5inrxcm 52 17 established establish VBN cord-352379-q5inrxcm 52 18 . . . cord-352379-q5inrxcm 53 1 It -PRON- PRP cord-352379-q5inrxcm 53 2 is be VBZ cord-352379-q5inrxcm 53 3 possible possible JJ cord-352379-q5inrxcm 53 4 that that IN cord-352379-q5inrxcm 53 5 civet civet NN cord-352379-q5inrxcm 53 6 cats cat NNS cord-352379-q5inrxcm 53 7 were be VBD cord-352379-q5inrxcm 53 8 infected infect VBN cord-352379-q5inrxcm 53 9 with with IN cord-352379-q5inrxcm 53 10 the the DT cord-352379-q5inrxcm 53 11 virus virus NN cord-352379-q5inrxcm 53 12 from from IN cord-352379-q5inrxcm 53 13 another another DT cord-352379-q5inrxcm 53 14 animal animal NN cord-352379-q5inrxcm 53 15 species specie NNS cord-352379-q5inrxcm 53 16 . . . cord-352379-q5inrxcm 54 1 In in IN cord-352379-q5inrxcm 54 2 either either DT cord-352379-q5inrxcm 54 3 case case NN cord-352379-q5inrxcm 54 4 , , , cord-352379-q5inrxcm 54 5 the the DT cord-352379-q5inrxcm 54 6 critical critical JJ cord-352379-q5inrxcm 54 7 questions question NNS cord-352379-q5inrxcm 54 8 are be VBP cord-352379-q5inrxcm 54 9 whether whether IN cord-352379-q5inrxcm 54 10 there there EX cord-352379-q5inrxcm 54 11 is be VBZ cord-352379-q5inrxcm 54 12 extensive extensive JJ cord-352379-q5inrxcm 54 13 horizontal horizontal JJ cord-352379-q5inrxcm 54 14 transmission transmission NN cord-352379-q5inrxcm 54 15 between between IN cord-352379-q5inrxcm 54 16 animals animal NNS cord-352379-q5inrxcm 54 17 , , , cord-352379-q5inrxcm 54 18 and and CC cord-352379-q5inrxcm 54 19 whether whether IN cord-352379-q5inrxcm 54 20 the the DT cord-352379-q5inrxcm 54 21 jump jump NN cord-352379-q5inrxcm 54 22 of of IN cord-352379-q5inrxcm 54 23 the the DT cord-352379-q5inrxcm 54 24 virus virus NN cord-352379-q5inrxcm 54 25 from from IN cord-352379-q5inrxcm 54 26 animals animal NNS cord-352379-q5inrxcm 54 27 to to IN cord-352379-q5inrxcm 54 28 human human NN cord-352379-q5inrxcm 54 29 was be VBD cord-352379-q5inrxcm 54 30 a a DT cord-352379-q5inrxcm 54 31 rare rare JJ cord-352379-q5inrxcm 54 32 and and CC cord-352379-q5inrxcm 54 33 accidental accidental JJ cord-352379-q5inrxcm 54 34 event event NN cord-352379-q5inrxcm 54 35 or or CC cord-352379-q5inrxcm 54 36 portends portend VBZ cord-352379-q5inrxcm 54 37 frequent frequent JJ cord-352379-q5inrxcm 54 38 occurrences occurrence NNS cord-352379-q5inrxcm 54 39 in in IN cord-352379-q5inrxcm 54 40 the the DT cord-352379-q5inrxcm 54 41 future future NN cord-352379-q5inrxcm 54 42 . . . cord-352379-q5inrxcm 55 1 The the DT cord-352379-q5inrxcm 55 2 answers answer NNS cord-352379-q5inrxcm 55 3 to to IN cord-352379-q5inrxcm 55 4 these these DT cord-352379-q5inrxcm 55 5 questions question NNS cord-352379-q5inrxcm 55 6 will will MD cord-352379-q5inrxcm 55 7 determine determine VB cord-352379-q5inrxcm 55 8 whether whether IN cord-352379-q5inrxcm 55 9 these these DT cord-352379-q5inrxcm 55 10 animals animal NNS cord-352379-q5inrxcm 55 11 are be VBP cord-352379-q5inrxcm 55 12 viable viable JJ cord-352379-q5inrxcm 55 13 reservoirs reservoir NNS cord-352379-q5inrxcm 55 14 for for IN cord-352379-q5inrxcm 55 15 future future JJ cord-352379-q5inrxcm 55 16 SARS SARS NNP cord-352379-q5inrxcm 55 17 outbreaks outbreak NNS cord-352379-q5inrxcm 55 18 . . . cord-352379-q5inrxcm 56 1 Thus thus RB cord-352379-q5inrxcm 56 2 , , , cord-352379-q5inrxcm 56 3 epidemiological epidemiological JJ cord-352379-q5inrxcm 56 4 studies study NNS cord-352379-q5inrxcm 56 5 of of IN cord-352379-q5inrxcm 56 6 coronavirus coronavirus NN cord-352379-q5inrxcm 56 7 infections infection NNS cord-352379-q5inrxcm 56 8 in in IN cord-352379-q5inrxcm 56 9 wild wild JJ cord-352379-q5inrxcm 56 10 animals animal NNS cord-352379-q5inrxcm 56 11 are be VBP cord-352379-q5inrxcm 56 12 critical critical JJ cord-352379-q5inrxcm 56 13 tbr tbr NNP cord-352379-q5inrxcm 56 14 control control NN cord-352379-q5inrxcm 56 15 of of IN cord-352379-q5inrxcm 56 16 future future JJ cord-352379-q5inrxcm 56 17 SARS SARS NNP cord-352379-q5inrxcm 56 18 outbreaks outbreak NNS cord-352379-q5inrxcm 56 19 . . . cord-352379-q5inrxcm 57 1 Although although IN cord-352379-q5inrxcm 57 2 coronaviruses coronaviruse NNS cord-352379-q5inrxcm 57 3 , , , cord-352379-q5inrxcm 57 4 in in IN cord-352379-q5inrxcm 57 5 general general JJ cord-352379-q5inrxcm 57 6 , , , cord-352379-q5inrxcm 57 7 infect infect VBP cord-352379-q5inrxcm 57 8 only only RB cord-352379-q5inrxcm 57 9 the the DT cord-352379-q5inrxcm 57 10 animal animal NN cord-352379-q5inrxcm 57 11 species species NN cord-352379-q5inrxcm 57 12 of of IN cord-352379-q5inrxcm 57 13 their -PRON- PRP$ cord-352379-q5inrxcm 57 14 natural natural JJ cord-352379-q5inrxcm 57 15 origin origin NN cord-352379-q5inrxcm 57 16 , , , cord-352379-q5inrxcm 57 17 they -PRON- PRP cord-352379-q5inrxcm 57 18 are be VBP cord-352379-q5inrxcm 57 19 known know VBN cord-352379-q5inrxcm 57 20 to to TO cord-352379-q5inrxcm 57 21 jump jump VB cord-352379-q5inrxcm 57 22 to to IN cord-352379-q5inrxcm 57 23 other other JJ cord-352379-q5inrxcm 57 24 species specie NNS cord-352379-q5inrxcm 57 25 relatively relatively RB cord-352379-q5inrxcm 57 26 easily easily RB cord-352379-q5inrxcm 57 27 . . . cord-352379-q5inrxcm 58 1 The the DT cord-352379-q5inrxcm 58 2 human human JJ cord-352379-q5inrxcm 58 3 coronavirus coronavirus NN cord-352379-q5inrxcm 58 4 OC43 OC43 NNP cord-352379-q5inrxcm 58 5 is be VBZ cord-352379-q5inrxcm 58 6 very very RB cord-352379-q5inrxcm 58 7 closely closely RB cord-352379-q5inrxcm 58 8 related related JJ cord-352379-q5inrxcm 58 9 in in IN cord-352379-q5inrxcm 58 10 genetic genetic JJ cord-352379-q5inrxcm 58 11 sequence sequence NN cord-352379-q5inrxcm 58 12 to to IN cord-352379-q5inrxcm 58 13 BCoV BCoV NNP cord-352379-q5inrxcm 58 14 [ [ -LRB- cord-352379-q5inrxcm 58 15 16 16 CD cord-352379-q5inrxcm 58 16 , , , cord-352379-q5inrxcm 58 17 36 36 CD cord-352379-q5inrxcm 58 18 ] ] -RRB- cord-352379-q5inrxcm 58 19 ; ; : cord-352379-q5inrxcm 58 20 thus thus RB cord-352379-q5inrxcm 58 21 , , , cord-352379-q5inrxcm 58 22 there there EX cord-352379-q5inrxcm 58 23 is be VBZ cord-352379-q5inrxcm 58 24 no no DT cord-352379-q5inrxcm 58 25 doubt doubt NN cord-352379-q5inrxcm 58 26 that that IN cord-352379-q5inrxcm 58 27 the the DT cord-352379-q5inrxcm 58 28 virus virus NN cord-352379-q5inrxcm 58 29 jumped jump VBD cord-352379-q5inrxcm 58 30 from from IN cord-352379-q5inrxcm 58 31 one one CD cord-352379-q5inrxcm 58 32 species specie NNS cord-352379-q5inrxcm 58 33 to to IN cord-352379-q5inrxcm 58 34 the the DT cord-352379-q5inrxcm 58 35 other other JJ cord-352379-q5inrxcm 58 36 . . . cord-352379-q5inrxcm 59 1 BCoV BCoV NNP cord-352379-q5inrxcm 59 2 has have VBZ cord-352379-q5inrxcm 59 3 also also RB cord-352379-q5inrxcm 59 4 been be VBN cord-352379-q5inrxcm 59 5 reported report VBN cord-352379-q5inrxcm 59 6 to to TO cord-352379-q5inrxcm 59 7 infect infect VB cord-352379-q5inrxcm 59 8 humans human NNS cord-352379-q5inrxcm 59 9 occasionally occasionally RB cord-352379-q5inrxcm 59 10 , , , cord-352379-q5inrxcm 59 11 causing cause VBG cord-352379-q5inrxcm 59 12 diarrhea diarrhea NN cord-352379-q5inrxcm 59 13 [ [ -LRB- cord-352379-q5inrxcm 59 14 31 31 CD cord-352379-q5inrxcm 59 15 , , , cord-352379-q5inrxcm 59 16 82 82 CD cord-352379-q5inrxcm 59 17 ] ] -RRB- cord-352379-q5inrxcm 59 18 . . . cord-352379-q5inrxcm 60 1 When when WRB cord-352379-q5inrxcm 60 2 MHV MHV NNP cord-352379-q5inrxcm 60 3 was be VBD cord-352379-q5inrxcm 60 4 passaged passage VBN cord-352379-q5inrxcm 60 5 in in IN cord-352379-q5inrxcm 60 6 tissue tissue NN cord-352379-q5inrxcm 60 7 culture culture NN cord-352379-q5inrxcm 60 8 cells cell NNS cord-352379-q5inrxcm 60 9 , , , cord-352379-q5inrxcm 60 10 the the DT cord-352379-q5inrxcm 60 11 virus virus NN cord-352379-q5inrxcm 60 12 eventually eventually RB cord-352379-q5inrxcm 60 13 adapted adapt VBD cord-352379-q5inrxcm 60 14 to to IN cord-352379-q5inrxcm 60 15 growing grow VBG cord-352379-q5inrxcm 60 16 in in IN cord-352379-q5inrxcm 60 17 human human JJ cord-352379-q5inrxcm 60 18 cells cell NNS cord-352379-q5inrxcm 60 19 [ [ -LRB- cord-352379-q5inrxcm 60 20 9 9 CD cord-352379-q5inrxcm 60 21 , , , cord-352379-q5inrxcm 60 22 10 10 CD cord-352379-q5inrxcm 60 23 ] ] -RRB- cord-352379-q5inrxcm 60 24 . . . cord-352379-q5inrxcm 61 1 Although although IN cord-352379-q5inrxcm 61 2 the the DT cord-352379-q5inrxcm 61 3 mechanism mechanism NN cord-352379-q5inrxcm 61 4 of of IN cord-352379-q5inrxcm 61 5 such such PDT cord-352379-q5inrxcm 61 6 an an DT cord-352379-q5inrxcm 61 7 adaptation adaptation NN cord-352379-q5inrxcm 61 8 is be VBZ cord-352379-q5inrxcm 61 9 not not RB cord-352379-q5inrxcm 61 10 known know VBN cord-352379-q5inrxcm 61 11 , , , cord-352379-q5inrxcm 61 12 it -PRON- PRP cord-352379-q5inrxcm 61 13 is be VBZ cord-352379-q5inrxcm 61 14 likely likely JJ cord-352379-q5inrxcm 61 15 that that IN cord-352379-q5inrxcm 61 16 it -PRON- PRP cord-352379-q5inrxcm 61 17 was be VBD cord-352379-q5inrxcm 61 18 the the DT cord-352379-q5inrxcm 61 19 result result NN cord-352379-q5inrxcm 61 20 of of IN cord-352379-q5inrxcm 61 21 mutations mutation NNS cord-352379-q5inrxcm 61 22 in in IN cord-352379-q5inrxcm 61 23 certain certain JJ cord-352379-q5inrxcm 61 24 viral viral JJ cord-352379-q5inrxcm 61 25 genes gene NNS cord-352379-q5inrxcm 61 26 . . . cord-352379-q5inrxcm 62 1 Thus thus RB cord-352379-q5inrxcm 62 2 , , , cord-352379-q5inrxcm 62 3 there there EX cord-352379-q5inrxcm 62 4 is be VBZ cord-352379-q5inrxcm 62 5 considerable considerable JJ cord-352379-q5inrxcm 62 6 latitude latitude NN cord-352379-q5inrxcm 62 7 in in IN cord-352379-q5inrxcm 62 8 species specie NNS cord-352379-q5inrxcm 62 9 specificity specificity NN cord-352379-q5inrxcm 62 10 of of IN cord-352379-q5inrxcm 62 11 coronaviruses coronaviruse NNS cord-352379-q5inrxcm 62 12 . . . cord-352379-q5inrxcm 63 1 So so RB cord-352379-q5inrxcm 63 2 far far RB cord-352379-q5inrxcm 63 3 , , , cord-352379-q5inrxcm 63 4 SARS SARS NNP cord-352379-q5inrxcm 63 5 virus virus NN cord-352379-q5inrxcm 63 6 has have VBZ cord-352379-q5inrxcm 63 7 been be VBN cord-352379-q5inrxcm 63 8 shown show VBN cord-352379-q5inrxcm 63 9 to to TO cord-352379-q5inrxcm 63 10 infect infect VB cord-352379-q5inrxcm 63 11 humans human NNS cord-352379-q5inrxcm 63 12 and and CC cord-352379-q5inrxcm 63 13 macaque macaque NN cord-352379-q5inrxcm 63 14 monkeys monkey NNS cord-352379-q5inrxcm 63 15 [ [ -LRB- cord-352379-q5inrxcm 63 16 25 25 CD cord-352379-q5inrxcm 63 17 ] ] -RRB- cord-352379-q5inrxcm 63 18 . . . cord-352379-q5inrxcm 64 1 Whether whether IN cord-352379-q5inrxcm 64 2 it -PRON- PRP cord-352379-q5inrxcm 64 3 can can MD cord-352379-q5inrxcm 64 4 infect infect VB cord-352379-q5inrxcm 64 5 other other JJ cord-352379-q5inrxcm 64 6 animal animal NN cord-352379-q5inrxcm 64 7 species specie NNS cord-352379-q5inrxcm 64 8 in in IN cord-352379-q5inrxcm 64 9 natural natural JJ cord-352379-q5inrxcm 64 10 infections infection NNS cord-352379-q5inrxcm 64 11 and and CC cord-352379-q5inrxcm 64 12 experimental experimental JJ cord-352379-q5inrxcm 64 13 inoculations inoculation NNS cord-352379-q5inrxcm 64 14 may may MD cord-352379-q5inrxcm 64 15 determine determine VB cord-352379-q5inrxcm 64 16 the the DT cord-352379-q5inrxcm 64 17 extent extent NN cord-352379-q5inrxcm 64 18 of of IN cord-352379-q5inrxcm 64 19 natural natural JJ cord-352379-q5inrxcm 64 20 reservoirs reservoir NNS cord-352379-q5inrxcm 64 21 for for IN cord-352379-q5inrxcm 64 22 SARS SARS NNP cord-352379-q5inrxcm 64 23 virus virus NN cord-352379-q5inrxcm 64 24 and and CC cord-352379-q5inrxcm 64 25 the the DT cord-352379-q5inrxcm 64 26 feasibility feasibility NN cord-352379-q5inrxcm 64 27 of of IN cord-352379-q5inrxcm 64 28 establishing establish VBG cord-352379-q5inrxcm 64 29 animal animal NN cord-352379-q5inrxcm 64 30 models model NNS cord-352379-q5inrxcm 64 31 for for IN cord-352379-q5inrxcm 64 32 it -PRON- PRP cord-352379-q5inrxcm 64 33 . . . cord-352379-q5inrxcm 65 1 Complete complete JJ cord-352379-q5inrxcm 65 2 SARS SARS NNP cord-352379-q5inrxcm 65 3 virus virus NN cord-352379-q5inrxcm 65 4 genome genome NN cord-352379-q5inrxcm 65 5 sequences sequence NNS cord-352379-q5inrxcm 65 6 have have VBP cord-352379-q5inrxcm 65 7 been be VBN cord-352379-q5inrxcm 65 8 determined determine VBN cord-352379-q5inrxcm 65 9 from from IN cord-352379-q5inrxcm 65 10 more more JJR cord-352379-q5inrxcm 65 11 than than IN cord-352379-q5inrxcm 65 12 twenty twenty CD cord-352379-q5inrxcm 65 13 different different JJ cord-352379-q5inrxcm 65 14 isolates isolate NNS cord-352379-q5inrxcm 65 15 so so RB cord-352379-q5inrxcm 65 16 far far RB cord-352379-q5inrxcm 65 17 . . . cord-352379-q5inrxcm 66 1 These these DT cord-352379-q5inrxcm 66 2 sequences sequence NNS cord-352379-q5inrxcm 66 3 showed show VBD cord-352379-q5inrxcm 66 4 extremely extremely RB cord-352379-q5inrxcm 66 5 high high JJ cord-352379-q5inrxcm 66 6 conservation conservation NN cord-352379-q5inrxcm 66 7 , , , cord-352379-q5inrxcm 66 8 indicating indicate VBG cord-352379-q5inrxcm 66 9 that that IN cord-352379-q5inrxcm 66 10 they -PRON- PRP cord-352379-q5inrxcm 66 11 were be VBD cord-352379-q5inrxcm 66 12 all all DT cord-352379-q5inrxcm 66 13 derived derive VBN cord-352379-q5inrxcm 66 14 from from IN cord-352379-q5inrxcm 66 15 a a DT cord-352379-q5inrxcm 66 16 common common JJ cord-352379-q5inrxcm 66 17 source source NN cord-352379-q5inrxcm 66 18 and and CC cord-352379-q5inrxcm 66 19 did do VBD cord-352379-q5inrxcm 66 20 not not RB cord-352379-q5inrxcm 66 21 diverge diverge VB cord-352379-q5inrxcm 66 22 significantly significantly RB cord-352379-q5inrxcm 66 23 during during IN cord-352379-q5inrxcm 66 24 the the DT cord-352379-q5inrxcm 66 25 first first JJ cord-352379-q5inrxcm 66 26 [ [ -LRB- cord-352379-q5inrxcm 66 27 55 55 CD cord-352379-q5inrxcm 66 28 , , , cord-352379-q5inrxcm 66 29 66 66 CD cord-352379-q5inrxcm 66 30 ] ] -RRB- cord-352379-q5inrxcm 66 31 . . . cord-352379-q5inrxcm 67 1 Sequence sequence NN cord-352379-q5inrxcm 67 2 comparison comparison NN cord-352379-q5inrxcm 67 3 with with IN cord-352379-q5inrxcm 67 4 those those DT cord-352379-q5inrxcm 67 5 of of IN cord-352379-q5inrxcm 67 6 ORFs orfs NN cord-352379-q5inrxcm 67 7 of of IN cord-352379-q5inrxcm 67 8 the the DT cord-352379-q5inrxcm 67 9 other other JJ cord-352379-q5inrxcm 67 10 known know VBN cord-352379-q5inrxcm 67 11 coronaviruses coronaviruse NNS cord-352379-q5inrxcm 67 12 reveals reveal VBZ cord-352379-q5inrxcm 67 13 a a DT cord-352379-q5inrxcm 67 14 similar similar JJ cord-352379-q5inrxcm 67 15 pattern pattern NN cord-352379-q5inrxcm 67 16 of of IN cord-352379-q5inrxcm 67 17 gene gene NN cord-352379-q5inrxcm 67 18 organization organization NN cord-352379-q5inrxcm 67 19 , , , cord-352379-q5inrxcm 67 20 namely namely RB cord-352379-q5inrxcm 67 21 , , , cord-352379-q5inrxcm 67 22 gene gene NN cord-352379-q5inrxcm 67 23 la la NNP cord-352379-q5inrxcm 67 24 - - HYPH cord-352379-q5inrxcm 67 25 lb lb JJ cord-352379-q5inrxcm 67 26 ( ( -LRB- cord-352379-q5inrxcm 67 27 replicase replicase NN cord-352379-q5inrxcm 67 28 and and CC cord-352379-q5inrxcm 67 29 protease protease NN cord-352379-q5inrxcm 67 30 genes gene NNS cord-352379-q5inrxcm 67 31 ) ) -RRB- cord-352379-q5inrxcm 67 32 , , , cord-352379-q5inrxcm 67 33 spike spike NN cord-352379-q5inrxcm 67 34 ( ( -LRB- cord-352379-q5inrxcm 67 35 S S NNP cord-352379-q5inrxcm 67 36 ) ) -RRB- cord-352379-q5inrxcm 67 37 , , , cord-352379-q5inrxcm 67 38 envelope envelope NN cord-352379-q5inrxcm 67 39 ( ( -LRB- cord-352379-q5inrxcm 67 40 E E NNP cord-352379-q5inrxcm 67 41 ) ) -RRB- cord-352379-q5inrxcm 67 42 , , , cord-352379-q5inrxcm 67 43 membrane membrane NN cord-352379-q5inrxcm 67 44 ( ( -LRB- cord-352379-q5inrxcm 67 45 M M NNP cord-352379-q5inrxcm 67 46 ) ) -RRB- cord-352379-q5inrxcm 67 47 and and CC cord-352379-q5inrxcm 67 48 nucleocapsid nucleocapsid NN cord-352379-q5inrxcm 67 49 ( ( -LRB- cord-352379-q5inrxcm 67 50 N N NNP cord-352379-q5inrxcm 67 51 ) ) -RRB- cord-352379-q5inrxcm 67 52 in in IN cord-352379-q5inrxcm 67 53 the the DT cord-352379-q5inrxcm 67 54 order order NN cord-352379-q5inrxcm 67 55 of of IN cord-352379-q5inrxcm 67 56 5 5 CD cord-352379-q5inrxcm 67 57 ' ' '' cord-352379-q5inrxcm 67 58 to to IN cord-352379-q5inrxcm 67 59 3 3 CD cord-352379-q5inrxcm 67 60 ' ' '' cord-352379-q5inrxcm 67 61 ends end NNS cord-352379-q5inrxcm 67 62 [ [ -LRB- cord-352379-q5inrxcm 67 63 48 48 CD cord-352379-q5inrxcm 67 64 ] ] -RRB- cord-352379-q5inrxcm 67 65 . . . cord-352379-q5inrxcm 68 1 Notably notably RB cord-352379-q5inrxcm 68 2 , , , cord-352379-q5inrxcm 68 3 the the DT cord-352379-q5inrxcm 68 4 SARS SARS NNP cord-352379-q5inrxcm 68 5 virus virus NN cord-352379-q5inrxcm 68 6 genome genome NN cord-352379-q5inrxcm 68 7 does do VBZ cord-352379-q5inrxcm 68 8 not not RB cord-352379-q5inrxcm 68 9 encode encode VB cord-352379-q5inrxcm 68 10 a a DT cord-352379-q5inrxcm 68 11 hemagglutinin hemagglutinin NN cord-352379-q5inrxcm 68 12 - - HYPH cord-352379-q5inrxcm 68 13 esterase esterase NN cord-352379-q5inrxcm 68 14 ( ( -LRB- cord-352379-q5inrxcm 68 15 HE he NN cord-352379-q5inrxcm 68 16 ) ) -RRB- cord-352379-q5inrxcm 68 17 protein protein NN cord-352379-q5inrxcm 68 18 , , , cord-352379-q5inrxcm 68 19 which which WDT cord-352379-q5inrxcm 68 20 is be VBZ cord-352379-q5inrxcm 68 21 present present JJ cord-352379-q5inrxcm 68 22 in in IN cord-352379-q5inrxcm 68 23 most most JJS cord-352379-q5inrxcm 68 24 of of IN cord-352379-q5inrxcm 68 25 the the DT cord-352379-q5inrxcm 68 26 group group NN cord-352379-q5inrxcm 68 27 II II NNP cord-352379-q5inrxcm 68 28 coronaviruses coronaviruse NNS cord-352379-q5inrxcm 68 29 . . . cord-352379-q5inrxcm 69 1 Interspersed intersperse VBN cord-352379-q5inrxcm 69 2 between between IN cord-352379-q5inrxcm 69 3 these these DT cord-352379-q5inrxcm 69 4 well well RB cord-352379-q5inrxcm 69 5 - - HYPH cord-352379-q5inrxcm 69 6 characterized characterize VBN cord-352379-q5inrxcm 69 7 genes gene NNS cord-352379-q5inrxcm 69 8 are be VBP cord-352379-q5inrxcm 69 9 a a DT cord-352379-q5inrxcm 69 10 series series NN cord-352379-q5inrxcm 69 11 of of IN cord-352379-q5inrxcm 69 12 ORFs orfs NN cord-352379-q5inrxcm 69 13 of of IN cord-352379-q5inrxcm 69 14 unknown unknown JJ cord-352379-q5inrxcm 69 15 functions function NNS cord-352379-q5inrxcm 69 16 . . . cord-352379-q5inrxcm 70 1 At at IN cord-352379-q5inrxcm 70 2 a a DT cord-352379-q5inrxcm 70 3 quick quick JJ cord-352379-q5inrxcm 70 4 glance glance NN cord-352379-q5inrxcm 70 5 , , , cord-352379-q5inrxcm 70 6 the the DT cord-352379-q5inrxcm 70 7 SARS SARS NNP cord-352379-q5inrxcm 70 8 virus virus NN cord-352379-q5inrxcm 70 9 RNA RNA NNP cord-352379-q5inrxcm 70 10 has have VBZ cord-352379-q5inrxcm 70 11 20RFs 20rfs CD cord-352379-q5inrxcm 70 12 between between IN cord-352379-q5inrxcm 70 13 the the DT cord-352379-q5inrxcm 70 14 S S NNP cord-352379-q5inrxcm 70 15 and and CC cord-352379-q5inrxcm 70 16 E e NN cord-352379-q5inrxcm 70 17 genes gene NNS cord-352379-q5inrxcm 70 18 and and CC cord-352379-q5inrxcm 70 19 an an DT cord-352379-q5inrxcm 70 20 additional additional JJ cord-352379-q5inrxcm 70 21 3 3 CD cord-352379-q5inrxcm 70 22 - - HYPH cord-352379-q5inrxcm 70 23 50RFs 50rfs CD cord-352379-q5inrxcm 70 24 between between IN cord-352379-q5inrxcm 70 25 the the DT cord-352379-q5inrxcm 70 26 M M NNP cord-352379-q5inrxcm 70 27 and and CC cord-352379-q5inrxcm 70 28 N n CD cord-352379-q5inrxcm 70 29 genes gene NNS cord-352379-q5inrxcm 70 30 . . . cord-352379-q5inrxcm 71 1 This this DT cord-352379-q5inrxcm 71 2 gene gene NN cord-352379-q5inrxcm 71 3 organization organization NN cord-352379-q5inrxcm 71 4 most most RBS cord-352379-q5inrxcm 71 5 closely closely RB cord-352379-q5inrxcm 71 6 resembles resemble VBZ cord-352379-q5inrxcm 71 7 that that DT cord-352379-q5inrxcm 71 8 of of IN cord-352379-q5inrxcm 71 9 group group NN cord-352379-q5inrxcm 71 10 III iii CD cord-352379-q5inrxcm 71 11 coronaviruses coronaviruse NNS cord-352379-q5inrxcm 71 12 . . . cord-352379-q5inrxcm 72 1 In in IN cord-352379-q5inrxcm 72 2 the the DT cord-352379-q5inrxcm 72 3 SARS SARS NNP cord-352379-q5inrxcm 72 4 virus virus NN cord-352379-q5inrxcm 72 5 genome genome NN cord-352379-q5inrxcm 72 6 , , , cord-352379-q5inrxcm 72 7 the the DT cord-352379-q5inrxcm 72 8 organization organization NN cord-352379-q5inrxcm 72 9 of of IN cord-352379-q5inrxcm 72 10 gene gene NNP cord-352379-q5inrxcm 72 11 la la NNP cord-352379-q5inrxcm 72 12 - - HYPH cord-352379-q5inrxcm 72 13 lb lb NNP cord-352379-q5inrxcm 72 14 , , , cord-352379-q5inrxcm 72 15 which which WDT cord-352379-q5inrxcm 72 16 accounts account VBZ cord-352379-q5inrxcm 72 17 for for IN cord-352379-q5inrxcm 72 18 more more JJR cord-352379-q5inrxcm 72 19 than than IN cord-352379-q5inrxcm 72 20 two two CD cord-352379-q5inrxcm 72 21 - - HYPH cord-352379-q5inrxcm 72 22 thirds third NNS cord-352379-q5inrxcm 72 23 of of IN cord-352379-q5inrxcm 72 24 the the DT cord-352379-q5inrxcm 72 25 viral viral JJ cord-352379-q5inrxcm 72 26 RNA RNA NNP cord-352379-q5inrxcm 72 27 , , , cord-352379-q5inrxcm 72 28 is be VBZ cord-352379-q5inrxcm 72 29 very very RB cord-352379-q5inrxcm 72 30 similar similar JJ cord-352379-q5inrxcm 72 31 to to IN cord-352379-q5inrxcm 72 32 that that DT cord-352379-q5inrxcm 72 33 of of IN cord-352379-q5inrxcm 72 34 the the DT cord-352379-q5inrxcm 72 35 murine murine JJ cord-352379-q5inrxcm 72 36 coronavirus coronavirus NN cord-352379-q5inrxcm 72 37 MHV MHV NNP cord-352379-q5inrxcm 72 38 , , , cord-352379-q5inrxcm 72 39 except except IN cord-352379-q5inrxcm 72 40 that that IN cord-352379-q5inrxcm 72 41 it -PRON- PRP cord-352379-q5inrxcm 72 42 contains contain VBZ cord-352379-q5inrxcm 72 43 only only RB cord-352379-q5inrxcm 72 44 one one CD cord-352379-q5inrxcm 72 45 papain papain NN cord-352379-q5inrxcm 72 46 - - HYPH cord-352379-q5inrxcm 72 47 like like JJ cord-352379-q5inrxcm 72 48 protease protease NN cord-352379-q5inrxcm 72 49 ( ( -LRB- cord-352379-q5inrxcm 72 50 PLpro-2 plpro-2 NN cord-352379-q5inrxcm 72 51 ) ) -RRB- cord-352379-q5inrxcm 72 52 ( ( -LRB- cord-352379-q5inrxcm 72 53 fig fig NN cord-352379-q5inrxcm 72 54 . . NNP cord-352379-q5inrxcm 72 55 2 2 CD cord-352379-q5inrxcm 72 56 ) ) -RRB- cord-352379-q5inrxcm 72 57 . . . cord-352379-q5inrxcm 73 1 Thus thus RB cord-352379-q5inrxcm 73 2 , , , cord-352379-q5inrxcm 73 3 the the DT cord-352379-q5inrxcm 73 4 PLpro-2 plpro-2 NN cord-352379-q5inrxcm 73 5 of of IN cord-352379-q5inrxcm 73 6 SARS SARS NNP cord-352379-q5inrxcm 73 7 virus virus NN cord-352379-q5inrxcm 73 8 is be VBZ cord-352379-q5inrxcm 73 9 likely likely RB cord-352379-q5inrxcm 73 10 responsible responsible JJ cord-352379-q5inrxcm 73 11 tbr tbr NNP cord-352379-q5inrxcm 73 12 the the DT cord-352379-q5inrxcm 73 13 cleavage cleavage NN cord-352379-q5inrxcm 73 14 of of IN cord-352379-q5inrxcm 73 15 all all PDT cord-352379-q5inrxcm 73 16 the the DT cord-352379-q5inrxcm 73 17 Nterminal Nterminal NNP cord-352379-q5inrxcm 73 18 proteins protein NNS cord-352379-q5inrxcm 73 19 of of IN cord-352379-q5inrxcm 73 20 gene gene NN cord-352379-q5inrxcm 73 21 l l NNP cord-352379-q5inrxcm 73 22 a a NNP cord-352379-q5inrxcm 73 23 , , , cord-352379-q5inrxcm 73 24 which which WDT cord-352379-q5inrxcm 73 25 is be VBZ cord-352379-q5inrxcm 73 26 normally normally RB cord-352379-q5inrxcm 73 27 carried carry VBN cord-352379-q5inrxcm 73 28 out out RP cord-352379-q5inrxcm 73 29 by by IN cord-352379-q5inrxcm 73 30 PLpro-1 PLpro-1 NNP cord-352379-q5inrxcm 73 31 in in IN cord-352379-q5inrxcm 73 32 murine murine JJ cord-352379-q5inrxcm 73 33 comnavirus comnavirus NNP cord-352379-q5inrxcm 73 34 [ [ -LRB- cord-352379-q5inrxcm 73 35 6 6 CD cord-352379-q5inrxcm 73 36 ] ] -RRB- cord-352379-q5inrxcm 73 37 . . . cord-352379-q5inrxcm 74 1 It -PRON- PRP cord-352379-q5inrxcm 74 2 is be VBZ cord-352379-q5inrxcm 74 3 noted note VBN cord-352379-q5inrxcm 74 4 that that IN cord-352379-q5inrxcm 74 5 group group NN cord-352379-q5inrxcm 74 6 III iii CD cord-352379-q5inrxcm 74 7 coronaviruses coronaviruse NNS cord-352379-q5inrxcm 74 8 have have VBP cord-352379-q5inrxcm 74 9 only only RB cord-352379-q5inrxcm 74 10 one one CD cord-352379-q5inrxcm 74 11 PLpro PLpro NNP cord-352379-q5inrxcm 74 12 . . . cord-352379-q5inrxcm 75 1 However however RB cord-352379-q5inrxcm 75 2 , , , cord-352379-q5inrxcm 75 3 the the DT cord-352379-q5inrxcm 75 4 SARS SARS NNP cord-352379-q5inrxcm 75 5 virus virus NN cord-352379-q5inrxcm 75 6 genome genome NN cord-352379-q5inrxcm 75 7 has have VBZ cord-352379-q5inrxcm 75 8 remnants remnant NNS cord-352379-q5inrxcm 75 9 of of IN cord-352379-q5inrxcm 75 10 the the DT cord-352379-q5inrxcm 75 11 PLpro PLpro NNP cord-352379-q5inrxcm 75 12 - - HYPH cord-352379-q5inrxcm 75 13 I -PRON- PRP cord-352379-q5inrxcm 75 14 sequence sequence NN cord-352379-q5inrxcm 75 15 ; ; : cord-352379-q5inrxcm 75 16 furthermore furthermore RB cord-352379-q5inrxcm 75 17 , , , cord-352379-q5inrxcm 75 18 the the DT cord-352379-q5inrxcm 75 19 SARS SARS NNP cord-352379-q5inrxcm 75 20 virus virus NN cord-352379-q5inrxcm 75 21 has have VBZ cord-352379-q5inrxcm 75 22 the the DT cord-352379-q5inrxcm 75 23 equivalent equivalent NN cord-352379-q5inrxcm 75 24 of of IN cord-352379-q5inrxcm 75 25 the the DT cord-352379-q5inrxcm 75 26 leader leader NN cord-352379-q5inrxcm 75 27 peptide peptide NN cord-352379-q5inrxcm 75 28 ( ( -LRB- cord-352379-q5inrxcm 75 29 p28 p28 CD cord-352379-q5inrxcm 75 30 ) ) -RRB- cord-352379-q5inrxcm 75 31 , , , cord-352379-q5inrxcm 75 32 which which WDT cord-352379-q5inrxcm 75 33 is be VBZ cord-352379-q5inrxcm 75 34 missing miss VBG cord-352379-q5inrxcm 75 35 in in IN cord-352379-q5inrxcm 75 36 the the DT cord-352379-q5inrxcm 75 37 group group NN cord-352379-q5inrxcm 75 38 III iii CD cord-352379-q5inrxcm 75 39 viruses virus NNS cord-352379-q5inrxcm 75 40 . . . cord-352379-q5inrxcm 76 1 The the DT cord-352379-q5inrxcm 76 2 remaining remain VBG cord-352379-q5inrxcm 76 3 sequences sequence NNS cord-352379-q5inrxcm 76 4 of of IN cord-352379-q5inrxcm 76 5 gene gene NN cord-352379-q5inrxcm 76 6 la la NNP cord-352379-q5inrxcm 76 7 - - HYPH cord-352379-q5inrxcm 76 8 lb lb NNP cord-352379-q5inrxcm 76 9 are be VBP cord-352379-q5inrxcm 76 10 highly highly RB cord-352379-q5inrxcm 76 11 conserved conserve VBN cord-352379-q5inrxcm 76 12 among among IN cord-352379-q5inrxcm 76 13 all all DT cord-352379-q5inrxcm 76 14 of of IN cord-352379-q5inrxcm 76 15 the the DT cord-352379-q5inrxcm 76 16 coronaviruses coronaviruse NNS cord-352379-q5inrxcm 76 17 [ [ -LRB- cord-352379-q5inrxcm 76 18 37 37 CD cord-352379-q5inrxcm 76 19 , , , cord-352379-q5inrxcm 76 20 68 68 CD cord-352379-q5inrxcm 76 21 ] ] -RRB- cord-352379-q5inrxcm 76 22 . . . cord-352379-q5inrxcm 77 1 Therefore therefore RB cord-352379-q5inrxcm 77 2 , , , cord-352379-q5inrxcm 77 3 ORFs ORFs NNP cord-352379-q5inrxcm 77 4 la la NN cord-352379-q5inrxcm 77 5 and and CC cord-352379-q5inrxcm 77 6 lb lb NNS cord-352379-q5inrxcm 77 7 are be VBP cord-352379-q5inrxcm 77 8 likely likely RB cord-352379-q5inrxcm 77 9 translated translate VBN cord-352379-q5inrxcm 77 10 into into IN cord-352379-q5inrxcm 77 11 a a DT cord-352379-q5inrxcm 77 12 polyprotein polyprotein NN cord-352379-q5inrxcm 77 13 by by IN cord-352379-q5inrxcm 77 14 a a DT cord-352379-q5inrxcm 77 15 ribosomal ribosomal JJ cord-352379-q5inrxcm 77 16 frameshifting frameshifting NN cord-352379-q5inrxcm 77 17 mechanism mechanism NN cord-352379-q5inrxcm 77 18 [ [ -LRB- cord-352379-q5inrxcm 77 19 12 12 CD cord-352379-q5inrxcm 77 20 ] ] -RRB- cord-352379-q5inrxcm 77 21 . . . cord-352379-q5inrxcm 78 1 All all DT cord-352379-q5inrxcm 78 2 of of IN cord-352379-q5inrxcm 78 3 the the DT cord-352379-q5inrxcm 78 4 potential potential JJ cord-352379-q5inrxcm 78 5 gene gene NN cord-352379-q5inrxcm 78 6 products product NNS cord-352379-q5inrxcm 78 7 in in IN cord-352379-q5inrxcm 78 8 gene gene NN cord-352379-q5inrxcm 78 9 la la NNP cord-352379-q5inrxcm 78 10 - - HYPH cord-352379-q5inrxcm 78 11 lb lb NNP cord-352379-q5inrxcm 78 12 are be VBP cord-352379-q5inrxcm 78 13 relatively relatively RB cord-352379-q5inrxcm 78 14 conserved conserve VBN cord-352379-q5inrxcm 78 15 between between IN cord-352379-q5inrxcm 78 16 SARS SARS NNP cord-352379-q5inrxcm 78 17 and and CC cord-352379-q5inrxcm 78 18 other other JJ cord-352379-q5inrxcm 78 19 coronaviruses coronaviruse NNS cord-352379-q5inrxcm 78 20 . . . cord-352379-q5inrxcm 79 1 The the DT cord-352379-q5inrxcm 79 2 3C 3c NN cord-352379-q5inrxcm 79 3 - - HYPH cord-352379-q5inrxcm 79 4 like like JJ cord-352379-q5inrxcm 79 5 protease protease NN cord-352379-q5inrxcm 79 6 ( ( -LRB- cord-352379-q5inrxcm 79 7 3CLpro 3clpro CD cord-352379-q5inrxcm 79 8 ) ) -RRB- cord-352379-q5inrxcm 79 9 is be VBZ cord-352379-q5inrxcm 79 10 likely likely RB cord-352379-q5inrxcm 79 11 responsible responsible JJ cord-352379-q5inrxcm 79 12 for for IN cord-352379-q5inrxcm 79 13 the the DT cord-352379-q5inrxcm 79 14 cleavage cleavage NN cord-352379-q5inrxcm 79 15 of of IN cord-352379-q5inrxcm 79 16 all all PDT cord-352379-q5inrxcm 79 17 the the DT cord-352379-q5inrxcm 79 18 remaining remain VBG cord-352379-q5inrxcm 79 19 proteins protein NNS cord-352379-q5inrxcm 79 20 in in IN cord-352379-q5inrxcm 79 21 gene gene NN cord-352379-q5inrxcm 79 22 1 1 CD cord-352379-q5inrxcm 79 23 a-1 a-1 NNP cord-352379-q5inrxcm 79 24 b b NNP cord-352379-q5inrxcm 79 25 [ [ -LRB- cord-352379-q5inrxcm 79 26 29 29 CD cord-352379-q5inrxcm 79 27 ] ] -RRB- cord-352379-q5inrxcm 79 28 . . . cord-352379-q5inrxcm 80 1 Based base VBN cord-352379-q5inrxcm 80 2 on on IN cord-352379-q5inrxcm 80 3 the the DT cord-352379-q5inrxcm 80 4 predicted predict VBN cord-352379-q5inrxcm 80 5 cleavage cleavage NN cord-352379-q5inrxcm 80 6 site site NN cord-352379-q5inrxcm 80 7 specificity specificity NN cord-352379-q5inrxcm 80 8 , , , cord-352379-q5inrxcm 80 9 the the DT cord-352379-q5inrxcm 80 10 SARS SARS NNP cord-352379-q5inrxcm 80 11 virus virus NN cord-352379-q5inrxcm 80 12 gene gene NNP cord-352379-q5inrxcm 80 13 la la NNP cord-352379-q5inrxcm 80 14 - - HYPH cord-352379-q5inrxcm 80 15 lb lb NNP cord-352379-q5inrxcm 80 16 is be VBZ cord-352379-q5inrxcm 80 17 likely likely RB cord-352379-q5inrxcm 80 18 processed process VBN cord-352379-q5inrxcm 80 19 into into IN cord-352379-q5inrxcm 80 20 thirteen thirteen CD cord-352379-q5inrxcm 80 21 final final JJ cord-352379-q5inrxcm 80 22 protein protein NN cord-352379-q5inrxcm 80 23 products product NNS cord-352379-q5inrxcm 80 24 . . . cord-352379-q5inrxcm 81 1 The the DT cord-352379-q5inrxcm 81 2 functions function NNS cord-352379-q5inrxcm 81 3 of of IN cord-352379-q5inrxcm 81 4 these these DT cord-352379-q5inrxcm 81 5 gene gene NN cord-352379-q5inrxcm 81 6 products product NNS cord-352379-q5inrxcm 81 7 are be VBP cord-352379-q5inrxcm 81 8 mostly mostly RB cord-352379-q5inrxcm 81 9 unknown unknown JJ cord-352379-q5inrxcm 81 10 ; ; : cord-352379-q5inrxcm 81 11 nevertheless nevertheless RB cord-352379-q5inrxcm 81 12 , , , cord-352379-q5inrxcm 81 13 they -PRON- PRP cord-352379-q5inrxcm 81 14 are be VBP cord-352379-q5inrxcm 81 15 likely likely RB cord-352379-q5inrxcm 81 16 involved involve VBN cord-352379-q5inrxcm 81 17 in in IN cord-352379-q5inrxcm 81 18 viral viral JJ cord-352379-q5inrxcm 81 19 RNA RNA NNP cord-352379-q5inrxcm 81 20 replication replication NN cord-352379-q5inrxcm 81 21 . . . cord-352379-q5inrxcm 82 1 In in IN cord-352379-q5inrxcm 82 2 MHV MHV NNP cord-352379-q5inrxcm 82 3 , , , cord-352379-q5inrxcm 82 4 all all PDT cord-352379-q5inrxcm 82 5 the the DT cord-352379-q5inrxcm 82 6 RNAnegative rnanegative NN cord-352379-q5inrxcm 82 7 temperature temperature NN cord-352379-q5inrxcm 82 8 - - HYPH cord-352379-q5inrxcm 82 9 sensitive sensitive JJ cord-352379-q5inrxcm 82 10 mutants mutant NNS cord-352379-q5inrxcm 82 11 are be VBP cord-352379-q5inrxcm 82 12 mapped map VBN cord-352379-q5inrxcm 82 13 in in IN cord-352379-q5inrxcm 82 14 the the DT cord-352379-q5inrxcm 82 15 genetic genetic JJ cord-352379-q5inrxcm 82 16 regions region NNS cord-352379-q5inrxcm 82 17 covering cover VBG cord-352379-q5inrxcm 82 18 almost almost RB cord-352379-q5inrxcm 82 19 the the DT cord-352379-q5inrxcm 82 20 entire entire JJ cord-352379-q5inrxcm 82 21 gene gene NN cord-352379-q5inrxcm 82 22 1 1 CD cord-352379-q5inrxcm 82 23 [ [ -LRB- cord-352379-q5inrxcm 82 24 8 8 CD cord-352379-q5inrxcm 82 25 ] ] -RRB- cord-352379-q5inrxcm 82 26 . . . cord-352379-q5inrxcm 83 1 [ [ -LRB- cord-352379-q5inrxcm 83 2 69 69 CD cord-352379-q5inrxcm 83 3 ] ] -RRB- cord-352379-q5inrxcm 83 4 . . . cord-352379-q5inrxcm 84 1 It -PRON- PRP cord-352379-q5inrxcm 84 2 should should MD cord-352379-q5inrxcm 84 3 be be VB cord-352379-q5inrxcm 84 4 noted note VBN cord-352379-q5inrxcm 84 5 that that IN cord-352379-q5inrxcm 84 6 some some DT cord-352379-q5inrxcm 84 7 of of IN cord-352379-q5inrxcm 84 8 the the DT cord-352379-q5inrxcm 84 9 protein protein NN cord-352379-q5inrxcm 84 10 - - HYPH cord-352379-q5inrxcm 84 11 processing process VBG cord-352379-q5inrxcm 84 12 intermediates intermediate NNS cord-352379-q5inrxcm 84 13 , , , cord-352379-q5inrxcm 84 14 in in IN cord-352379-q5inrxcm 84 15 addition addition NN cord-352379-q5inrxcm 84 16 to to IN cord-352379-q5inrxcm 84 17 the the DT cord-352379-q5inrxcm 84 18 final final JJ cord-352379-q5inrxcm 84 19 products product NNS cord-352379-q5inrxcm 84 20 , , , cord-352379-q5inrxcm 84 21 may may MD cord-352379-q5inrxcm 84 22 also also RB cord-352379-q5inrxcm 84 23 function function VB cord-352379-q5inrxcm 84 24 in in IN cord-352379-q5inrxcm 84 25 viral viral JJ cord-352379-q5inrxcm 84 26 replication replication NN cord-352379-q5inrxcm 84 27 . . . cord-352379-q5inrxcm 85 1 Overall overall RB cord-352379-q5inrxcm 85 2 , , , cord-352379-q5inrxcm 85 3 from from IN cord-352379-q5inrxcm 85 4 the the DT cord-352379-q5inrxcm 85 5 perspective perspective NN cord-352379-q5inrxcm 85 6 of of IN cord-352379-q5inrxcm 85 7 gene gene NN cord-352379-q5inrxcm 85 8 organization organization NN cord-352379-q5inrxcm 85 9 , , , cord-352379-q5inrxcm 85 10 the the DT cord-352379-q5inrxcm 85 11 5"-half 5"-half CD cord-352379-q5inrxcm 85 12 of of IN cord-352379-q5inrxcm 85 13 the the DT cord-352379-q5inrxcm 85 14 SARS SARS NNP cord-352379-q5inrxcm 85 15 virus virus NN cord-352379-q5inrxcm 85 16 genome genome NN cord-352379-q5inrxcm 85 17 appears appear VBZ cord-352379-q5inrxcm 85 18 to to TO cord-352379-q5inrxcm 85 19 be be VB cord-352379-q5inrxcm 85 20 more more RBR cord-352379-q5inrxcm 85 21 closely closely RB cord-352379-q5inrxcm 85 22 related relate VBN cord-352379-q5inrxcm 85 23 to to IN cord-352379-q5inrxcm 85 24 group group NN cord-352379-q5inrxcm 85 25 II ii CD cord-352379-q5inrxcm 85 26 viruses virus NNS cord-352379-q5inrxcm 85 27 , , , cord-352379-q5inrxcm 85 28 whereas whereas IN cord-352379-q5inrxcm 85 29 the the DT cord-352379-q5inrxcm 85 30 3"-half 3"-half NN cord-352379-q5inrxcm 85 31 more more RBR cord-352379-q5inrxcm 85 32 closely closely RB cord-352379-q5inrxcm 85 33 resembles resemble VBZ cord-352379-q5inrxcm 85 34 group group NN cord-352379-q5inrxcm 85 35 III iii CD cord-352379-q5inrxcm 85 36 virnses virnse NNS cord-352379-q5inrxcm 85 37 . . . cord-352379-q5inrxcm 86 1 Therefore therefore RB cord-352379-q5inrxcm 86 2 , , , cord-352379-q5inrxcm 86 3 SARS SARS NNP cord-352379-q5inrxcm 86 4 virus virus NN cord-352379-q5inrxcm 86 5 may may MD cord-352379-q5inrxcm 86 6 have have VB cord-352379-q5inrxcm 86 7 been be VBN cord-352379-q5inrxcm 86 8 derived derive VBN cord-352379-q5inrxcm 86 9 from from IN cord-352379-q5inrxcm 86 10 recombination recombination NN cord-352379-q5inrxcm 86 11 between between IN cord-352379-q5inrxcm 86 12 a a DT cord-352379-q5inrxcm 86 13 group group NN cord-352379-q5inrxcm 86 14 II II NNP cord-352379-q5inrxcm 86 15 and and CC cord-352379-q5inrxcm 86 16 a a DT cord-352379-q5inrxcm 86 17 group group NN cord-352379-q5inrxcm 86 18 III iii CD cord-352379-q5inrxcm 86 19 virus virus NN cord-352379-q5inrxcm 86 20 . . . cord-352379-q5inrxcm 87 1 However however RB cord-352379-q5inrxcm 87 2 , , , cord-352379-q5inrxcm 87 3 the the DT cord-352379-q5inrxcm 87 4 published publish VBN cord-352379-q5inrxcm 87 5 sequence sequence NN cord-352379-q5inrxcm 87 6 analysis analysis NN cord-352379-q5inrxcm 87 7 indicated indicate VBD cord-352379-q5inrxcm 87 8 that that IN cord-352379-q5inrxcm 87 9 the the DT cord-352379-q5inrxcm 87 10 entire entire JJ cord-352379-q5inrxcm 87 11 SARS SARS NNP cord-352379-q5inrxcm 87 12 virus virus NN cord-352379-q5inrxcm 87 13 RNA RNA NNP cord-352379-q5inrxcm 87 14 resembled resemble VBD cord-352379-q5inrxcm 87 15 that that DT cord-352379-q5inrxcm 87 16 of of IN cord-352379-q5inrxcm 87 17 group group NN cord-352379-q5inrxcm 87 18 II ii CD cord-352379-q5inrxcm 87 19 viruses virus NNS cord-352379-q5inrxcm 87 20 ; ; : cord-352379-q5inrxcm 87 21 no no DT cord-352379-q5inrxcm 87 22 evidence evidence NN cord-352379-q5inrxcm 87 23 of of IN cord-352379-q5inrxcm 87 24 recombination recombination NN cord-352379-q5inrxcm 87 25 was be VBD cord-352379-q5inrxcm 87 26 noted note VBN cord-352379-q5inrxcm 87 27 [ [ -LRB- cord-352379-q5inrxcm 87 28 55 55 CD cord-352379-q5inrxcm 87 29 , , , cord-352379-q5inrxcm 87 30 66 66 CD cord-352379-q5inrxcm 87 31 ] ] -RRB- cord-352379-q5inrxcm 87 32 . . . cord-352379-q5inrxcm 88 1 Since since IN cord-352379-q5inrxcm 88 2 the the DT cord-352379-q5inrxcm 88 3 genetic genetic JJ cord-352379-q5inrxcm 88 4 sequence sequence NN cord-352379-q5inrxcm 88 5 of of IN cord-352379-q5inrxcm 88 6 SARS SARS NNP cord-352379-q5inrxcm 88 7 virus virus NN cord-352379-q5inrxcm 88 8 is be VBZ cord-352379-q5inrxcm 88 9 approximately approximately RB cord-352379-q5inrxcm 88 10 equidistant equidistant JJ cord-352379-q5inrxcm 88 11 between between IN cord-352379-q5inrxcm 88 12 group group NN cord-352379-q5inrxcm 88 13 II II NNP cord-352379-q5inrxcm 88 14 and and CC cord-352379-q5inrxcm 88 15 III III NNP cord-352379-q5inrxcm 88 16 viruses virus NNS cord-352379-q5inrxcm 88 17 , , , cord-352379-q5inrxcm 88 18 the the DT cord-352379-q5inrxcm 88 19 possible possible JJ cord-352379-q5inrxcm 88 20 presence presence NN cord-352379-q5inrxcm 88 21 of of IN cord-352379-q5inrxcm 88 22 recombination recombination NN cord-352379-q5inrxcm 88 23 might may MD cord-352379-q5inrxcm 88 24 not not RB cord-352379-q5inrxcm 88 25 have have VB cord-352379-q5inrxcm 88 26 been be VBN cord-352379-q5inrxcm 88 27 evident evident JJ cord-352379-q5inrxcm 88 28 from from IN cord-352379-q5inrxcm 88 29 sequence sequence NN cord-352379-q5inrxcm 88 30 analysis analysis NN cord-352379-q5inrxcm 88 31 alone alone RB cord-352379-q5inrxcm 88 32 . . . cord-352379-q5inrxcm 89 1 Regardless regardless RB cord-352379-q5inrxcm 89 2 , , , cord-352379-q5inrxcm 89 3 recombination recombination NN cord-352379-q5inrxcm 89 4 is be VBZ cord-352379-q5inrxcm 89 5 probably probably RB cord-352379-q5inrxcm 89 6 not not RB cord-352379-q5inrxcm 89 7 the the DT cord-352379-q5inrxcm 89 8 triggering trigger VBG cord-352379-q5inrxcm 89 9 event event NN cord-352379-q5inrxcm 89 10 for for IN cord-352379-q5inrxcm 89 11 the the DT cord-352379-q5inrxcm 89 12 jumping jumping NN cord-352379-q5inrxcm 89 13 of of IN cord-352379-q5inrxcm 89 14 the the DT cord-352379-q5inrxcm 89 15 virus virus NN cord-352379-q5inrxcm 89 16 from from IN cord-352379-q5inrxcm 89 17 animals animal NNS cord-352379-q5inrxcm 89 18 to to IN cord-352379-q5inrxcm 89 19 humans human NNS cord-352379-q5inrxcm 89 20 , , , cord-352379-q5inrxcm 89 21 since since IN cord-352379-q5inrxcm 89 22 the the DT cord-352379-q5inrxcm 89 23 recombination recombination NN cord-352379-q5inrxcm 89 24 most most RBS cord-352379-q5inrxcm 89 25 likely likely RB cord-352379-q5inrxcm 89 26 occurred occur VBD cord-352379-q5inrxcm 89 27 between between IN cord-352379-q5inrxcm 89 28 the the DT cord-352379-q5inrxcm 89 29 ancestral ancestral JJ cord-352379-q5inrxcm 89 30 coronaviruses coronaviruse NNS cord-352379-q5inrxcm 89 31 . . . cord-352379-q5inrxcm 90 1 Coronavirus Coronavirus NNP cord-352379-q5inrxcm 90 2 genes gene NNS cord-352379-q5inrxcm 90 3 ( ( -LRB- cord-352379-q5inrxcm 90 4 except except IN cord-352379-q5inrxcm 90 5 for for IN cord-352379-q5inrxcm 90 6 gene gene NN cord-352379-q5inrxcm 90 7 1 1 CD cord-352379-q5inrxcm 90 8 ) ) -RRB- cord-352379-q5inrxcm 90 9 are be VBP cord-352379-q5inrxcm 90 10 typically typically RB cord-352379-q5inrxcm 90 11 expressed express VBN cord-352379-q5inrxcm 90 12 from from IN cord-352379-q5inrxcm 90 13 subgenomic subgenomic NNP cord-352379-q5inrxcm 90 14 mRNAs mRNAs NNP cord-352379-q5inrxcm 90 15 , , , cord-352379-q5inrxcm 90 16 which which WDT cord-352379-q5inrxcm 90 17 share share VBP cord-352379-q5inrxcm 90 18 a a DT cord-352379-q5inrxcm 90 19 common common JJ cord-352379-q5inrxcm 90 20 leader leader NN cord-352379-q5inrxcm 90 21 sequence sequence NN cord-352379-q5inrxcm 90 22 at at IN cord-352379-q5inrxcm 90 23 the the DT cord-352379-q5inrxcm 90 24 5'-end 5'-end CD cord-352379-q5inrxcm 90 25 , , , cord-352379-q5inrxcm 90 26 but but CC cord-352379-q5inrxcm 90 27 initiate initiate VB cord-352379-q5inrxcm 90 28 at at IN cord-352379-q5inrxcm 90 29 different different JJ cord-352379-q5inrxcm 90 30 places place NNS cord-352379-q5inrxcm 90 31 from from IN cord-352379-q5inrxcm 90 32 the the DT cord-352379-q5inrxcm 90 33 consensus consensus NN cord-352379-q5inrxcm 90 34 intergenic intergenic JJ cord-352379-q5inrxcm 90 35 sequences sequence NNS cord-352379-q5inrxcm 90 36 or or CC cord-352379-q5inrxcm 90 37 transcription transcription NN cord-352379-q5inrxcm 90 38 regulatory regulatory JJ cord-352379-q5inrxcm 90 39 sequences sequence NNS cord-352379-q5inrxcm 90 40 ( ( -LRB- cord-352379-q5inrxcm 90 41 TRS TRS NNP cord-352379-q5inrxcm 90 42 ) ) -RRB- cord-352379-q5inrxcm 90 43 in in IN cord-352379-q5inrxcm 90 44 the the DT cord-352379-q5inrxcm 90 45 genome genome NN cord-352379-q5inrxcm 90 46 and and CC cord-352379-q5inrxcm 90 47 extend extend VB cord-352379-q5inrxcm 90 48 toward toward IN cord-352379-q5inrxcm 90 49 the the DT cord-352379-q5inrxcm 90 50 3'-end 3'-end CD cord-352379-q5inrxcm 90 51 of of IN cord-352379-q5inrxcm 90 52 the the DT cord-352379-q5inrxcm 90 53 genome genome NN cord-352379-q5inrxcm 90 54 [ [ -LRB- cord-352379-q5inrxcm 90 55 48 48 CD cord-352379-q5inrxcm 90 56 ] ] -RRB- cord-352379-q5inrxcm 90 57 . . . cord-352379-q5inrxcm 91 1 The the DT cord-352379-q5inrxcm 91 2 transcription transcription NN cord-352379-q5inrxcm 91 3 initiation initiation NN cord-352379-q5inrxcm 91 4 sequences sequence NNS cord-352379-q5inrxcm 91 5 are be VBP cord-352379-q5inrxcm 91 6 typically typically RB cord-352379-q5inrxcm 91 7 rich rich JJ cord-352379-q5inrxcm 91 8 in in IN cord-352379-q5inrxcm 91 9 U U NNP cord-352379-q5inrxcm 91 10 , , , cord-352379-q5inrxcm 91 11 C C NNP cord-352379-q5inrxcm 91 12 , , , cord-352379-q5inrxcm 91 13 and and CC cord-352379-q5inrxcm 91 14 A a DT cord-352379-q5inrxcm 91 15 residues residue NNS cord-352379-q5inrxcm 91 16 and and CC cord-352379-q5inrxcm 91 17 highly highly RB cord-352379-q5inrxcm 91 18 conserved conserve VBN cord-352379-q5inrxcm 91 19 in in IN cord-352379-q5inrxcm 91 20 front front NN cord-352379-q5inrxcm 91 21 of of IN cord-352379-q5inrxcm 91 22 each each DT cord-352379-q5inrxcm 91 23 gene gene NN cord-352379-q5inrxcm 91 24 . . . cord-352379-q5inrxcm 92 1 Each each DT cord-352379-q5inrxcm 92 2 mRNA mrna NN cord-352379-q5inrxcm 92 3 ( ( -LRB- cord-352379-q5inrxcm 92 4 except except IN cord-352379-q5inrxcm 92 5 for for IN cord-352379-q5inrxcm 92 6 the the DT cord-352379-q5inrxcm 92 7 smallest small JJS cord-352379-q5inrxcm 92 8 ) ) -RRB- cord-352379-q5inrxcm 92 9 is be VBZ cord-352379-q5inrxcm 92 10 physically physically RB cord-352379-q5inrxcm 92 11 polycistronic polycistronic JJ cord-352379-q5inrxcm 92 12 , , , cord-352379-q5inrxcm 92 13 but but CC cord-352379-q5inrxcm 92 14 can can MD cord-352379-q5inrxcm 92 15 be be VB cord-352379-q5inrxcm 92 16 used use VBN cord-352379-q5inrxcm 92 17 to to TO cord-352379-q5inrxcm 92 18 translate translate VB cord-352379-q5inrxcm 92 19 only only RB cord-352379-q5inrxcm 92 20 the the DT cord-352379-q5inrxcm 92 21 5'-most 5'-most CD cord-352379-q5inrxcm 92 22 ORF ORF NNP cord-352379-q5inrxcm 92 23 . . . cord-352379-q5inrxcm 93 1 In in IN cord-352379-q5inrxcm 93 2 rare rare JJ cord-352379-q5inrxcm 93 3 situations situation NNS cord-352379-q5inrxcm 93 4 , , , cord-352379-q5inrxcm 93 5 several several JJ cord-352379-q5inrxcm 93 6 ORFs orf NNS cord-352379-q5inrxcm 93 7 are be VBP cord-352379-q5inrxcm 93 8 translated translate VBN cord-352379-q5inrxcm 93 9 from from IN cord-352379-q5inrxcm 93 10 a a DT cord-352379-q5inrxcm 93 11 single single JJ cord-352379-q5inrxcm 93 12 mRNA mrna NN cord-352379-q5inrxcm 93 13 , , , cord-352379-q5inrxcm 93 14 e.g. e.g. RB cord-352379-q5inrxcm 93 15 mRNA mRNA NNP cord-352379-q5inrxcm 93 16 3 3 CD cord-352379-q5inrxcm 93 17 of of IN cord-352379-q5inrxcm 93 18 IBV IBV NNP cord-352379-q5inrxcm 93 19 and and CC cord-352379-q5inrxcm 93 20 mRNA mRNA NNP cord-352379-q5inrxcm 93 21 5 5 CD cord-352379-q5inrxcm 93 22 of of IN cord-352379-q5inrxcm 93 23 MHV MHV NNP cord-352379-q5inrxcm 93 24 , , , cord-352379-q5inrxcm 93 25 by by IN cord-352379-q5inrxcm 93 26 internal internal JJ cord-352379-q5inrxcm 93 27 initiation initiation NN cord-352379-q5inrxcm 93 28 or or CC cord-352379-q5inrxcm 93 29 other other JJ cord-352379-q5inrxcm 93 30 mechanisms mechanism NNS cord-352379-q5inrxcm 93 31 , , , cord-352379-q5inrxcm 93 32 such such JJ cord-352379-q5inrxcm 93 33 as as IN cord-352379-q5inrxcm 93 34 an an DT cord-352379-q5inrxcm 93 35 internal internal JJ cord-352379-q5inrxcm 93 36 ribosomal ribosomal JJ cord-352379-q5inrxcm 93 37 entry entry NN cord-352379-q5inrxcm 93 38 site site NN cord-352379-q5inrxcm 93 39 , , , cord-352379-q5inrxcm 93 40 which which WDT cord-352379-q5inrxcm 93 41 are be VBP cord-352379-q5inrxcm 93 42 not not RB cord-352379-q5inrxcm 93 43 completely completely RB cord-352379-q5inrxcm 93 44 understood understand VBN cord-352379-q5inrxcm 93 45 . . . cord-352379-q5inrxcm 94 1 These these DT cord-352379-q5inrxcm 94 2 unconventional unconventional JJ cord-352379-q5inrxcm 94 3 translation translation NN cord-352379-q5inrxcm 94 4 mechanisms mechanism NNS cord-352379-q5inrxcm 94 5 are be VBP cord-352379-q5inrxcm 94 6 not not RB cord-352379-q5inrxcm 94 7 efficient efficient JJ cord-352379-q5inrxcm 94 8 ; ; : cord-352379-q5inrxcm 94 9 as as IN cord-352379-q5inrxcm 94 10 a a DT cord-352379-q5inrxcm 94 11 result result NN cord-352379-q5inrxcm 94 12 , , , cord-352379-q5inrxcm 94 13 these these DT cord-352379-q5inrxcm 94 14 gene gene NN cord-352379-q5inrxcm 94 15 products product NNS cord-352379-q5inrxcm 94 16 are be VBP cord-352379-q5inrxcm 94 17 usually usually RB cord-352379-q5inrxcm 94 18 not not RB cord-352379-q5inrxcm 94 19 very very RB cord-352379-q5inrxcm 94 20 abundant abundant JJ cord-352379-q5inrxcm 94 21 . . . cord-352379-q5inrxcm 95 1 These these DT cord-352379-q5inrxcm 95 2 ORFs orf NNS cord-352379-q5inrxcm 95 3 typically typically RB cord-352379-q5inrxcm 95 4 encode encode VBP cord-352379-q5inrxcm 95 5 viral viral JJ cord-352379-q5inrxcm 95 6 nonstructural nonstructural JJ cord-352379-q5inrxcm 95 7 proteins protein NNS cord-352379-q5inrxcm 95 8 , , , cord-352379-q5inrxcm 95 9 except except IN cord-352379-q5inrxcm 95 10 for for IN cord-352379-q5inrxcm 95 11 the the DT cord-352379-q5inrxcm 95 12 E e NN cord-352379-q5inrxcm 95 13 protein protein NN cord-352379-q5inrxcm 95 14 in in IN cord-352379-q5inrxcm 95 15 some some DT cord-352379-q5inrxcm 95 16 coronaviruses coronaviruse NNS cord-352379-q5inrxcm 95 17 . . . cord-352379-q5inrxcm 96 1 Significantly significantly RB cord-352379-q5inrxcm 96 2 , , , cord-352379-q5inrxcm 96 3 the the DT cord-352379-q5inrxcm 96 4 ORFs orfs NN cord-352379-q5inrxcm 96 5 between between IN cord-352379-q5inrxcm 96 6 the the DT cord-352379-q5inrxcm 96 7 structural structural JJ cord-352379-q5inrxcm 96 8 protein protein NN cord-352379-q5inrxcm 96 9 genes gene NNS cord-352379-q5inrxcm 96 10 are be VBP cord-352379-q5inrxcm 96 11 extremely extremely RB cord-352379-q5inrxcm 96 12 heterogeneous heterogeneous JJ cord-352379-q5inrxcm 96 13 among among IN cord-352379-q5inrxcm 96 14 different different JJ cord-352379-q5inrxcm 96 15 coronaviruses coronaviruse NNS cord-352379-q5inrxcm 96 16 in in IN cord-352379-q5inrxcm 96 17 terms term NNS cord-352379-q5inrxcm 96 18 of of IN cord-352379-q5inrxcm 96 19 the the DT cord-352379-q5inrxcm 96 20 number number NN cord-352379-q5inrxcm 96 21 of of IN cord-352379-q5inrxcm 96 22 potential potential JJ cord-352379-q5inrxcm 96 23 gene gene NN cord-352379-q5inrxcm 96 24 products product NNS cord-352379-q5inrxcm 96 25 and and CC cord-352379-q5inrxcm 96 26 the the DT cord-352379-q5inrxcm 96 27 method method NN cord-352379-q5inrxcm 96 28 of of IN cord-352379-q5inrxcm 96 29 their -PRON- PRP$ cord-352379-q5inrxcm 96 30 expression expression NN cord-352379-q5inrxcm 96 31 . . . cord-352379-q5inrxcm 97 1 They -PRON- PRP cord-352379-q5inrxcm 97 2 are be VBP cord-352379-q5inrxcm 97 3 not not RB cord-352379-q5inrxcm 97 4 essential essential JJ cord-352379-q5inrxcm 97 5 for for IN cord-352379-q5inrxcm 97 6 viral viral JJ cord-352379-q5inrxcm 97 7 replication replication NN cord-352379-q5inrxcm 97 8 in in IN cord-352379-q5inrxcm 97 9 cell cell NN cord-352379-q5inrxcm 97 10 culture culture NN cord-352379-q5inrxcm 97 11 ; ; : cord-352379-q5inrxcm 97 12 however however RB cord-352379-q5inrxcm 97 13 , , , cord-352379-q5inrxcm 97 14 recent recent JJ cord-352379-q5inrxcm 97 15 studies study NNS cord-352379-q5inrxcm 97 16 suggest suggest VBP cord-352379-q5inrxcm 97 17 that that IN cord-352379-q5inrxcm 97 18 deletions deletion NNS cord-352379-q5inrxcm 97 19 of of IN cord-352379-q5inrxcm 97 20 these these DT cord-352379-q5inrxcm 97 21 ' ' `` cord-352379-q5inrxcm 97 22 nonessential nonessential JJ cord-352379-q5inrxcm 97 23 ' ' '' cord-352379-q5inrxcm 97 24 ORFs orfs NN cord-352379-q5inrxcm 97 25 could could MD cord-352379-q5inrxcm 97 26 result result VB cord-352379-q5inrxcm 97 27 in in IN cord-352379-q5inrxcm 97 28 the the DT cord-352379-q5inrxcm 97 29 reduction reduction NN cord-352379-q5inrxcm 97 30 of of IN cord-352379-q5inrxcm 97 31 viral viral JJ cord-352379-q5inrxcm 97 32 virulence virulence NN cord-352379-q5inrxcm 97 33 [ [ -LRB- cord-352379-q5inrxcm 97 34 19 19 CD cord-352379-q5inrxcm 97 35 , , , cord-352379-q5inrxcm 97 36 61 61 CD cord-352379-q5inrxcm 97 37 ] ] -RRB- cord-352379-q5inrxcm 97 38 . . . cord-352379-q5inrxcm 98 1 Conceivably conceivably RB cord-352379-q5inrxcm 98 2 , , , cord-352379-q5inrxcm 98 3 some some DT cord-352379-q5inrxcm 98 4 of of IN cord-352379-q5inrxcm 98 5 these these DT cord-352379-q5inrxcm 98 6 ORFs orf NNS cord-352379-q5inrxcm 98 7 in in IN cord-352379-q5inrxcm 98 8 SARS SARS NNP cord-352379-q5inrxcm 98 9 virus virus NN cord-352379-q5inrxcm 98 10 could could MD cord-352379-q5inrxcm 98 11 be be VB cord-352379-q5inrxcm 98 12 responsible responsible JJ cord-352379-q5inrxcm 98 13 for for IN cord-352379-q5inrxcm 98 14 the the DT cord-352379-q5inrxcm 98 15 high high JJ cord-352379-q5inrxcm 98 16 virulence virulence NN cord-352379-q5inrxcm 98 17 of of IN cord-352379-q5inrxcm 98 18 this this DT cord-352379-q5inrxcm 98 19 virus virus NN cord-352379-q5inrxcm 98 20 . . . cord-352379-q5inrxcm 99 1 A a DT cord-352379-q5inrxcm 99 2 report report NN cord-352379-q5inrxcm 99 3 shows show VBZ cord-352379-q5inrxcm 99 4 that that IN cord-352379-q5inrxcm 99 5 five five CD cord-352379-q5inrxcm 99 6 subgenomic subgenomic JJ cord-352379-q5inrxcm 99 7 mRNAs mRNAs NNPS cord-352379-q5inrxcm 99 8 were be VBD cord-352379-q5inrxcm 99 9 detected detect VBN cord-352379-q5inrxcm 99 10 in in IN cord-352379-q5inrxcm 99 11 Vero Vero NNP cord-352379-q5inrxcm 99 12 cells cell NNS cord-352379-q5inrxcm 99 13 infected infect VBN cord-352379-q5inrxcm 99 14 with with IN cord-352379-q5inrxcm 99 15 the the DT cord-352379-q5inrxcm 99 16 SARS SARS NNP cord-352379-q5inrxcm 99 17 virus virus NN cord-352379-q5inrxcm 99 18 [ [ -LRB- cord-352379-q5inrxcm 99 19 66 66 CD cord-352379-q5inrxcm 99 20 ] ] -RRB- cord-352379-q5inrxcm 99 21 . . . cord-352379-q5inrxcm 100 1 Thus thus RB cord-352379-q5inrxcm 100 2 , , , cord-352379-q5inrxcm 100 3 some some DT cord-352379-q5inrxcm 100 4 of of IN cord-352379-q5inrxcm 100 5 the the DT cord-352379-q5inrxcm 100 6 ORFs orf NNS cord-352379-q5inrxcm 100 7 are be VBP cord-352379-q5inrxcm 100 8 expected expect VBN cord-352379-q5inrxcm 100 9 to to TO cord-352379-q5inrxcm 100 10 be be VB cord-352379-q5inrxcm 100 11 expressed express VBN cord-352379-q5inrxcm 100 12 by by IN cord-352379-q5inrxcm 100 13 internal internal JJ cord-352379-q5inrxcm 100 14 initiation initiation NN cord-352379-q5inrxcm 100 15 if if IN cord-352379-q5inrxcm 100 16 they -PRON- PRP cord-352379-q5inrxcm 100 17 are be VBP cord-352379-q5inrxcm 100 18 translated translate VBN cord-352379-q5inrxcm 100 19 at at RB cord-352379-q5inrxcm 100 20 all all RB cord-352379-q5inrxcm 100 21 . . . cord-352379-q5inrxcm 101 1 However however RB cord-352379-q5inrxcm 101 2 , , , cord-352379-q5inrxcm 101 3 it -PRON- PRP cord-352379-q5inrxcm 101 4 is be VBZ cord-352379-q5inrxcm 101 5 possible possible JJ cord-352379-q5inrxcm 101 6 that that IN cord-352379-q5inrxcm 101 7 additional additional JJ cord-352379-q5inrxcm 101 8 subgenomic subgenomic NN cord-352379-q5inrxcm 101 9 mRNAs mRNAs NNPS cord-352379-q5inrxcm 101 10 are be VBP cord-352379-q5inrxcm 101 11 transcribed transcribe VBN cord-352379-q5inrxcm 101 12 ; ; : cord-352379-q5inrxcm 101 13 the the DT cord-352379-q5inrxcm 101 14 amounts amount NNS cord-352379-q5inrxcm 101 15 of of IN cord-352379-q5inrxcm 101 16 the the DT cord-352379-q5inrxcm 101 17 various various JJ cord-352379-q5inrxcm 101 18 subgenomic subgenomic NN cord-352379-q5inrxcm 101 19 mRNAs mRNAs NNPS cord-352379-q5inrxcm 101 20 vary vary VBP cord-352379-q5inrxcm 101 21 tremendously tremendously RB cord-352379-q5inrxcm 101 22 among among IN cord-352379-q5inrxcm 101 23 different different JJ cord-352379-q5inrxcm 101 24 coronaviruses coronaviruse NNS cord-352379-q5inrxcm 101 25 , , , cord-352379-q5inrxcm 101 26 depending depend VBG cord-352379-q5inrxcm 101 27 on on IN cord-352379-q5inrxcm 101 28 the the DT cord-352379-q5inrxcm 101 29 strength strength NN cord-352379-q5inrxcm 101 30 of of IN cord-352379-q5inrxcm 101 31 the the DT cord-352379-q5inrxcm 101 32 transcription transcription NN cord-352379-q5inrxcm 101 33 - - HYPH cord-352379-q5inrxcm 101 34 start start NN cord-352379-q5inrxcm 101 35 signals signal NNS cord-352379-q5inrxcm 101 36 [ [ -LRB- cord-352379-q5inrxcm 101 37 48 48 CD cord-352379-q5inrxcm 101 38 ] ] -RRB- cord-352379-q5inrxcm 101 39 . . . cord-352379-q5inrxcm 102 1 The the DT cord-352379-q5inrxcm 102 2 less less RBR cord-352379-q5inrxcm 102 3 abundant abundant JJ cord-352379-q5inrxcm 102 4 subgenomic subgenomic NN cord-352379-q5inrxcm 102 5 mRNAs mrnas $ cord-352379-q5inrxcm 102 6 frequently frequently RB cord-352379-q5inrxcm 102 7 were be VBD cord-352379-q5inrxcm 102 8 missed miss VBN cord-352379-q5inrxcm 102 9 in in IN cord-352379-q5inrxcm 102 10 northern northern JJ cord-352379-q5inrxcm 102 11 blot blot NN cord-352379-q5inrxcm 102 12 analysis analysis NN cord-352379-q5inrxcm 102 13 . . . cord-352379-q5inrxcm 103 1 Indeed indeed RB cord-352379-q5inrxcm 103 2 , , , cord-352379-q5inrxcm 103 3 the the DT cord-352379-q5inrxcm 103 4 analysis analysis NN cord-352379-q5inrxcm 103 5 of of IN cord-352379-q5inrxcm 103 6 the the DT cord-352379-q5inrxcm 103 7 SARS SARS NNP cord-352379-q5inrxcm 103 8 virus virus NN cord-352379-q5inrxcm 103 9 genome genome NN cord-352379-q5inrxcm 103 10 detected detect VBD cord-352379-q5inrxcm 103 11 many many JJ cord-352379-q5inrxcm 103 12 more more JJR cord-352379-q5inrxcm 103 13 consensus consensus NN cord-352379-q5inrxcm 103 14 intergenic intergenic JJ cord-352379-q5inrxcm 103 15 sequences sequence NNS cord-352379-q5inrxcm 103 16 ( ( -LRB- cord-352379-q5inrxcm 103 17 UCUAAAC UCUAAAC NNP cord-352379-q5inrxcm 103 18 and and CC cord-352379-q5inrxcm 103 19 related related JJ cord-352379-q5inrxcm 103 20 sequences sequence NNS cord-352379-q5inrxcm 103 21 ) ) -RRB- cord-352379-q5inrxcm 103 22 , , , cord-352379-q5inrxcm 103 23 which which WDT cord-352379-q5inrxcm 103 24 can can MD cord-352379-q5inrxcm 103 25 potentially potentially RB cord-352379-q5inrxcm 103 26 be be VB cord-352379-q5inrxcm 103 27 used use VBN cord-352379-q5inrxcm 103 28 for for IN cord-352379-q5inrxcm 103 29 transcription transcription NN cord-352379-q5inrxcm 103 30 initiation initiation NN cord-352379-q5inrxcm 103 31 [ [ -LRB- cord-352379-q5inrxcm 103 32 55 55 CD cord-352379-q5inrxcm 103 33 , , , cord-352379-q5inrxcm 103 34 66 66 CD cord-352379-q5inrxcm 103 35 ] ] -RRB- cord-352379-q5inrxcm 103 36 . . . cord-352379-q5inrxcm 104 1 A a DT cord-352379-q5inrxcm 104 2 recent recent JJ cord-352379-q5inrxcm 104 3 study study NN cord-352379-q5inrxcm 104 4 detected detect VBD cord-352379-q5inrxcm 104 5 eight eight CD cord-352379-q5inrxcm 104 6 subgenomic subgenomic NNP cord-352379-q5inrxcm 104 7 mRNA mRNA NNP cord-352379-q5inrxcm 104 8 species specie NNS cord-352379-q5inrxcm 104 9 in in IN cord-352379-q5inrxcm 104 10 SARS SARS NNP cord-352379-q5inrxcm 104 11 virus virus NN cord-352379-q5inrxcm 104 12 - - HYPH cord-352379-q5inrxcm 104 13 infected infect VBN cord-352379-q5inrxcm 104 14 cells cell NNS cord-352379-q5inrxcm 104 15 [ [ -LRB- cord-352379-q5inrxcm 104 16 70 70 CD cord-352379-q5inrxcm 104 17 ] ] -RRB- cord-352379-q5inrxcm 104 18 . . . cord-352379-q5inrxcm 105 1 In in IN cord-352379-q5inrxcm 105 2 general general JJ cord-352379-q5inrxcm 105 3 , , , cord-352379-q5inrxcm 105 4 coronaviruses coronaviruse NNS cord-352379-q5inrxcm 105 5 have have VBP cord-352379-q5inrxcm 105 6 four four CD cord-352379-q5inrxcm 105 7 envelope envelope NN cord-352379-q5inrxcm 105 8 proteins protein NNS cord-352379-q5inrxcm 105 9 : : : cord-352379-q5inrxcm 105 10 S S NNP cord-352379-q5inrxcm 105 11 , , , cord-352379-q5inrxcm 105 12 M M NNP cord-352379-q5inrxcm 105 13 , , , cord-352379-q5inrxcm 105 14 E E NNP cord-352379-q5inrxcm 105 15 and and CC cord-352379-q5inrxcm 105 16 HE HE NNP cord-352379-q5inrxcm 105 17 . . . cord-352379-q5inrxcm 106 1 The the DT cord-352379-q5inrxcm 106 2 spike spike NN cord-352379-q5inrxcm 106 3 protein protein NN cord-352379-q5inrxcm 106 4 forms form VBZ cord-352379-q5inrxcm 106 5 the the DT cord-352379-q5inrxcm 106 6 characteristic characteristic JJ cord-352379-q5inrxcm 106 7 spikes spike NNS cord-352379-q5inrxcm 106 8 that that WDT cord-352379-q5inrxcm 106 9 are be VBP cord-352379-q5inrxcm 106 10 the the DT cord-352379-q5inrxcm 106 11 namesake namesake NN cord-352379-q5inrxcm 106 12 of of IN cord-352379-q5inrxcm 106 13 the the DT cord-352379-q5inrxcm 106 14 virus virus NN cord-352379-q5inrxcm 106 15 . . . cord-352379-q5inrxcm 107 1 The the DT cord-352379-q5inrxcm 107 2 S S NNP cord-352379-q5inrxcm 107 3 protein protein NN cord-352379-q5inrxcm 107 4 is be VBZ cord-352379-q5inrxcm 107 5 often often RB cord-352379-q5inrxcm 107 6 cleaved cleave VBN cord-352379-q5inrxcm 107 7 into into IN cord-352379-q5inrxcm 107 8 S1 s1 NN cord-352379-q5inrxcm 107 9 and and CC cord-352379-q5inrxcm 107 10 $ $ $ cord-352379-q5inrxcm 107 11 2 2 CD cord-352379-q5inrxcm 107 12 domains domain NNS cord-352379-q5inrxcm 107 13 by by IN cord-352379-q5inrxcm 107 14 intra intra JJ cord-352379-q5inrxcm 107 15 - - JJ cord-352379-q5inrxcm 107 16 and and CC cord-352379-q5inrxcm 107 17 extracellular extracellular JJ cord-352379-q5inrxcm 107 18 proteases protease NNS cord-352379-q5inrxcm 107 19 ; ; : cord-352379-q5inrxcm 107 20 the the DT cord-352379-q5inrxcm 107 21 cleavage cleavage NN cord-352379-q5inrxcm 107 22 often often RB cord-352379-q5inrxcm 107 23 enhances enhance VBZ cord-352379-q5inrxcm 107 24 the the DT cord-352379-q5inrxcm 107 25 viral viral JJ cord-352379-q5inrxcm 107 26 infectivity infectivity NN cord-352379-q5inrxcm 107 27 [ [ -LRB- cord-352379-q5inrxcm 107 28 28 28 CD cord-352379-q5inrxcm 107 29 ] ] -RRB- cord-352379-q5inrxcm 107 30 . . . cord-352379-q5inrxcm 108 1 However however RB cord-352379-q5inrxcm 108 2 , , , cord-352379-q5inrxcm 108 3 the the DT cord-352379-q5inrxcm 108 4 S S NNP cord-352379-q5inrxcm 108 5 protein protein NN cord-352379-q5inrxcm 108 6 of of IN cord-352379-q5inrxcm 108 7 some some DT cord-352379-q5inrxcm 108 8 viruses virus NNS cord-352379-q5inrxcm 108 9 , , , cord-352379-q5inrxcm 108 10 such such JJ cord-352379-q5inrxcm 108 11 as as IN cord-352379-q5inrxcm 108 12 feline feline JJ cord-352379-q5inrxcm 108 13 , , , cord-352379-q5inrxcm 108 14 is be VBZ cord-352379-q5inrxcm 108 15 not not RB cord-352379-q5inrxcm 108 16 cleaved cleave VBN cord-352379-q5inrxcm 108 17 , , , cord-352379-q5inrxcm 108 18 and and CC cord-352379-q5inrxcm 108 19 yet yet RB cord-352379-q5inrxcm 108 20 the the DT cord-352379-q5inrxcm 108 21 virus virus NN cord-352379-q5inrxcm 108 22 is be VBZ cord-352379-q5inrxcm 108 23 fully fully RB cord-352379-q5inrxcm 108 24 infectious infectious JJ cord-352379-q5inrxcm 108 25 [ [ -LRB- cord-352379-q5inrxcm 108 26 18 18 CD cord-352379-q5inrxcm 108 27 ] ] -RRB- cord-352379-q5inrxcm 108 28 . . . cord-352379-q5inrxcm 109 1 Sequence sequence NN cord-352379-q5inrxcm 109 2 analysis analysis NN cord-352379-q5inrxcm 109 3 of of IN cord-352379-q5inrxcm 109 4 the the DT cord-352379-q5inrxcm 109 5 S S NNP cord-352379-q5inrxcm 109 6 protein protein NN cord-352379-q5inrxcm 109 7 of of IN cord-352379-q5inrxcm 109 8 SARS SARS NNP cord-352379-q5inrxcm 109 9 virus virus NN cord-352379-q5inrxcm 109 10 suggests suggest VBZ cord-352379-q5inrxcm 109 11 that that IN cord-352379-q5inrxcm 109 12 it -PRON- PRP cord-352379-q5inrxcm 109 13 will will MD cord-352379-q5inrxcm 109 14 not not RB cord-352379-q5inrxcm 109 15 be be VB cord-352379-q5inrxcm 109 16 cleaved cleave VBN cord-352379-q5inrxcm 109 17 . . . cord-352379-q5inrxcm 110 1 The the DT cord-352379-q5inrxcm 110 2 spikes spike NNS cord-352379-q5inrxcm 110 3 bind bind VBP cord-352379-q5inrxcm 110 4 to to IN cord-352379-q5inrxcm 110 5 the the DT cord-352379-q5inrxcm 110 6 receptor receptor NN cord-352379-q5inrxcm 110 7 on on IN cord-352379-q5inrxcm 110 8 the the DT cord-352379-q5inrxcm 110 9 target target NN cord-352379-q5inrxcm 110 10 cells cell NNS cord-352379-q5inrxcm 110 11 ; ; : cord-352379-q5inrxcm 110 12 the the DT cord-352379-q5inrxcm 110 13 receptor receptor NN cord-352379-q5inrxcm 110 14 - - HYPH cord-352379-q5inrxcm 110 15 bind bind NN cord-352379-q5inrxcm 110 16 - - HYPH cord-352379-q5inrxcm 110 17 ing e VBG cord-352379-q5inrxcm 110 18 domain domain NN cord-352379-q5inrxcm 110 19 is be VBZ cord-352379-q5inrxcm 110 20 typically typically RB cord-352379-q5inrxcm 110 21 localized localize VBN cord-352379-q5inrxcm 110 22 in in IN cord-352379-q5inrxcm 110 23 the the DT cord-352379-q5inrxcm 110 24 N n NN cord-352379-q5inrxcm 110 25 - - HYPH cord-352379-q5inrxcm 110 26 terminus terminus NN cord-352379-q5inrxcm 110 27 of of IN cord-352379-q5inrxcm 110 28 the the DT cord-352379-q5inrxcm 110 29 S1 S1 NNP cord-352379-q5inrxcm 110 30 domain domain NN cord-352379-q5inrxcm 110 31 [ [ -LRB- cord-352379-q5inrxcm 110 32 27 27 CD cord-352379-q5inrxcm 110 33 , , , cord-352379-q5inrxcm 110 34 42 42 CD cord-352379-q5inrxcm 110 35 ] ] -RRB- cord-352379-q5inrxcm 110 36 . . . cord-352379-q5inrxcm 111 1 The the DT cord-352379-q5inrxcm 111 2 spike spike NN cord-352379-q5inrxcm 111 3 consists consist VBZ cord-352379-q5inrxcm 111 4 of of IN cord-352379-q5inrxcm 111 5 oligomeric oligomeric JJ cord-352379-q5inrxcm 111 6 structures structure NNS cord-352379-q5inrxcm 111 7 , , , cord-352379-q5inrxcm 111 8 which which WDT cord-352379-q5inrxcm 111 9 are be VBP cord-352379-q5inrxcm 111 10 formed form VBN cord-352379-q5inrxcm 111 11 by by IN cord-352379-q5inrxcm 111 12 the the DT cord-352379-q5inrxcm 111 13 heptad heptad NN cord-352379-q5inrxcm 111 14 repeats repeat VBZ cord-352379-q5inrxcm 111 15 in in IN cord-352379-q5inrxcm 111 16 the the DT cord-352379-q5inrxcm 111 17 $ $ $ cord-352379-q5inrxcm 111 18 2 2 CD cord-352379-q5inrxcm 111 19 domain domain NN cord-352379-q5inrxcm 111 20 ( ( -LRB- cord-352379-q5inrxcm 111 21 fig fig NN cord-352379-q5inrxcm 111 22 . . . cord-352379-q5inrxcm 111 23 3 3 CD cord-352379-q5inrxcm 111 24 ) ) -RRB- cord-352379-q5inrxcm 111 25 . . . cord-352379-q5inrxcm 112 1 Typically typically RB cord-352379-q5inrxcm 112 2 , , , cord-352379-q5inrxcm 112 3 there there EX cord-352379-q5inrxcm 112 4 are be VBP cord-352379-q5inrxcm 112 5 two two CD cord-352379-q5inrxcm 112 6 heptad heptad NN cord-352379-q5inrxcm 112 7 repeats repeat VBZ cord-352379-q5inrxcm 112 8 in in IN cord-352379-q5inrxcm 112 9 the the DT cord-352379-q5inrxcm 112 10 coronavirus coronavirus NN cord-352379-q5inrxcm 112 11 $ $ $ cord-352379-q5inrxcm 112 12 2 2 CD cord-352379-q5inrxcm 112 13 proteins protein NNS cord-352379-q5inrxcm 112 14 . . . cord-352379-q5inrxcm 113 1 $ $ $ cord-352379-q5inrxcm 113 2 2 2 CD cord-352379-q5inrxcm 113 3 also also RB cord-352379-q5inrxcm 113 4 contains contain VBZ cord-352379-q5inrxcm 113 5 a a DT cord-352379-q5inrxcm 113 6 fusion fusion NN cord-352379-q5inrxcm 113 7 peptide peptide NN cord-352379-q5inrxcm 113 8 sequence sequence NN cord-352379-q5inrxcm 113 9 , , , cord-352379-q5inrxcm 113 10 which which WDT cord-352379-q5inrxcm 113 11 is be VBZ cord-352379-q5inrxcm 113 12 responsible responsible JJ cord-352379-q5inrxcm 113 13 for for IN cord-352379-q5inrxcm 113 14 the the DT cord-352379-q5inrxcm 113 15 fusion fusion NN cord-352379-q5inrxcm 113 16 activity activity NN cord-352379-q5inrxcm 113 17 associated associate VBN cord-352379-q5inrxcm 113 18 with with IN cord-352379-q5inrxcm 113 19 coronaviruses coronaviruse NNS cord-352379-q5inrxcm 113 20 . . . cord-352379-q5inrxcm 114 1 Significantly significantly RB cord-352379-q5inrxcm 114 2 , , , cord-352379-q5inrxcm 114 3 the the DT cord-352379-q5inrxcm 114 4 optimum optimum JJ cord-352379-q5inrxcm 114 5 pH ph NN cord-352379-q5inrxcm 114 6 for for IN cord-352379-q5inrxcm 114 7 the the DT cord-352379-q5inrxcm 114 8 spike spike NN cord-352379-q5inrxcm 114 9 - - HYPH cord-352379-q5inrxcm 114 10 induced induce VBN cord-352379-q5inrxcm 114 11 fusion fusion NN cord-352379-q5inrxcm 114 12 differs differ VBZ cord-352379-q5inrxcm 114 13 from from IN cord-352379-q5inrxcm 114 14 virus virus NN cord-352379-q5inrxcm 114 15 to to IN cord-352379-q5inrxcm 114 16 virus virus NN cord-352379-q5inrxcm 114 17 ; ; : cord-352379-q5inrxcm 114 18 while while IN cord-352379-q5inrxcm 114 19 most most JJS cord-352379-q5inrxcm 114 20 MHV MHV NNP cord-352379-q5inrxcm 114 21 strains strain NNS cord-352379-q5inrxcm 114 22 cause cause VBP cord-352379-q5inrxcm 114 23 fusion fusion NN cord-352379-q5inrxcm 114 24 at at IN cord-352379-q5inrxcm 114 25 the the DT cord-352379-q5inrxcm 114 26 neutral neutral JJ cord-352379-q5inrxcm 114 27 pH pH NNP cord-352379-q5inrxcm 114 28 [ [ -LRB- cord-352379-q5inrxcm 114 29 77 77 CD cord-352379-q5inrxcm 114 30 ] ] -RRB- cord-352379-q5inrxcm 114 31 , , , cord-352379-q5inrxcm 114 32 some some DT cord-352379-q5inrxcm 114 33 variant variant NN cord-352379-q5inrxcm 114 34 viruses virus NNS cord-352379-q5inrxcm 114 35 induce induce VBP cord-352379-q5inrxcm 114 36 fusion fusion NN cord-352379-q5inrxcm 114 37 at at IN cord-352379-q5inrxcm 114 38 pH pH NNP cord-352379-q5inrxcm 114 39 6.5 6.5 CD cord-352379-q5inrxcm 114 40 [ [ -LRB- cord-352379-q5inrxcm 114 41 26 26 CD cord-352379-q5inrxcm 114 42 ] ] -RRB- cord-352379-q5inrxcm 114 43 . . . cord-352379-q5inrxcm 115 1 Since since IN cord-352379-q5inrxcm 115 2 the the DT cord-352379-q5inrxcm 115 3 pH pH NNP cord-352379-q5inrxcm 115 4 requirement requirement NN cord-352379-q5inrxcm 115 5 of of IN cord-352379-q5inrxcm 115 6 membrane membrane NN cord-352379-q5inrxcm 115 7 fusion fusion NN cord-352379-q5inrxcm 115 8 dictates dictate VBZ cord-352379-q5inrxcm 115 9 the the DT cord-352379-q5inrxcm 115 10 mechanism mechanism NN cord-352379-q5inrxcm 115 11 of of IN cord-352379-q5inrxcm 115 12 virus virus NN cord-352379-q5inrxcm 115 13 entry entry NN cord-352379-q5inrxcm 115 14 ( ( -LRB- cord-352379-q5inrxcm 115 15 either either CC cord-352379-q5inrxcm 115 16 by by IN cord-352379-q5inrxcm 115 17 fusion fusion NN cord-352379-q5inrxcm 115 18 at at IN cord-352379-q5inrxcm 115 19 the the DT cord-352379-q5inrxcm 115 20 plasma plasma NN cord-352379-q5inrxcm 115 21 membrane membrane NN cord-352379-q5inrxcm 115 22 or or CC cord-352379-q5inrxcm 115 23 by by IN cord-352379-q5inrxcm 115 24 endocytosis endocytosis NN cord-352379-q5inrxcm 115 25 ) ) -RRB- cord-352379-q5inrxcm 115 26 , , , cord-352379-q5inrxcm 115 27 different different JJ cord-352379-q5inrxcm 115 28 coronaviruses coronaviruse NNS cord-352379-q5inrxcm 115 29 may may MD cord-352379-q5inrxcm 115 30 use use VB cord-352379-q5inrxcm 115 31 different different JJ cord-352379-q5inrxcm 115 32 entry entry NN cord-352379-q5inrxcm 115 33 mechanisms mechanism NNS cord-352379-q5inrxcm 115 34 . . . cord-352379-q5inrxcm 116 1 SARS SARS NNP cord-352379-q5inrxcm 116 2 virus virus NN cord-352379-q5inrxcm 116 3 also also RB cord-352379-q5inrxcm 116 4 causes cause VBZ cord-352379-q5inrxcm 116 5 syncytia syncytia NN cord-352379-q5inrxcm 116 6 formation formation NN cord-352379-q5inrxcm 116 7 in in IN cord-352379-q5inrxcm 116 8 vivo vivo NN cord-352379-q5inrxcm 116 9 , , , cord-352379-q5inrxcm 116 10 but but CC cord-352379-q5inrxcm 116 11 not not RB cord-352379-q5inrxcm 116 12 in in IN cord-352379-q5inrxcm 116 13 the the DT cord-352379-q5inrxcm 116 14 cultured cultured JJ cord-352379-q5inrxcm 116 15 Vero Vero NNP cord-352379-q5inrxcm 116 16 cells cell NNS cord-352379-q5inrxcm 116 17 [ [ -LRB- cord-352379-q5inrxcm 116 18 41 41 CD cord-352379-q5inrxcm 116 19 ] ] -RRB- cord-352379-q5inrxcm 116 20 . . . cord-352379-q5inrxcm 117 1 As as IN cord-352379-q5inrxcm 117 2 the the DT cord-352379-q5inrxcm 117 3 S S NNP cord-352379-q5inrxcm 117 4 protein protein NN cord-352379-q5inrxcm 117 5 of of IN cord-352379-q5inrxcm 117 6 SARS SARS NNP cord-352379-q5inrxcm 117 7 virus virus NN cord-352379-q5inrxcm 117 8 possesses possess VBZ cord-352379-q5inrxcm 117 9 most most JJS cord-352379-q5inrxcm 117 10 of of IN cord-352379-q5inrxcm 117 11 the the DT cord-352379-q5inrxcm 117 12 features feature NNS cord-352379-q5inrxcm 117 13 of of IN cord-352379-q5inrxcm 117 14 the the DT cord-352379-q5inrxcm 117 15 S S NNP cord-352379-q5inrxcm 117 16 proteins protein NNS cord-352379-q5inrxcm 117 17 of of IN cord-352379-q5inrxcm 117 18 other other JJ cord-352379-q5inrxcm 117 19 coronaviruses coronaviruse NNS cord-352379-q5inrxcm 117 20 , , , cord-352379-q5inrxcm 117 21 it -PRON- PRP cord-352379-q5inrxcm 117 22 will will MD cord-352379-q5inrxcm 117 23 be be VB cord-352379-q5inrxcm 117 24 interesting interesting JJ cord-352379-q5inrxcm 117 25 to to TO cord-352379-q5inrxcm 117 26 know know VB cord-352379-q5inrxcm 117 27 the the DT cord-352379-q5inrxcm 117 28 conditions condition NNS cord-352379-q5inrxcm 117 29 , , , cord-352379-q5inrxcm 117 30 such such JJ cord-352379-q5inrxcm 117 31 as as IN cord-352379-q5inrxcm 117 32 protease protease NN cord-352379-q5inrxcm 117 33 sensitivity sensitivity NN cord-352379-q5inrxcm 117 34 and and CC cord-352379-q5inrxcm 117 35 pH ph NN cord-352379-q5inrxcm 117 36 dependence dependence NN cord-352379-q5inrxcm 117 37 of of IN cord-352379-q5inrxcm 117 38 membrane membrane NN cord-352379-q5inrxcm 117 39 fusion fusion NN cord-352379-q5inrxcm 117 40 , , , cord-352379-q5inrxcm 117 41 that that WDT cord-352379-q5inrxcm 117 42 enhance enhance VBP cord-352379-q5inrxcm 117 43 the the DT cord-352379-q5inrxcm 117 44 SARS SARS NNP cord-352379-q5inrxcm 117 45 virus virus NN cord-352379-q5inrxcm 117 46 infectivity infectivity NN cord-352379-q5inrxcm 117 47 . . . cord-352379-q5inrxcm 118 1 It -PRON- PRP cord-352379-q5inrxcm 118 2 should should MD cord-352379-q5inrxcm 118 3 be be VB cord-352379-q5inrxcm 118 4 noted note VBN cord-352379-q5inrxcm 118 5 that that IN cord-352379-q5inrxcm 118 6 both both DT cord-352379-q5inrxcm 118 7 S1 s1 NN cord-352379-q5inrxcm 118 8 and and CC cord-352379-q5inrxcm 118 9 $ $ $ cord-352379-q5inrxcm 118 10 2 2 CD cord-352379-q5inrxcm 118 11 contain contain VBP cord-352379-q5inrxcm 118 12 the the DT cord-352379-q5inrxcm 118 13 neutralization neutralization NN cord-352379-q5inrxcm 118 14 epitopes epitope NNS cord-352379-q5inrxcm 118 15 of of IN cord-352379-q5inrxcm 118 16 MHV MHV NNP cord-352379-q5inrxcm 118 17 [ [ -LRB- cord-352379-q5inrxcm 118 18 48 48 CD cord-352379-q5inrxcm 118 19 ] ] -RRB- cord-352379-q5inrxcm 118 20 and and CC cord-352379-q5inrxcm 118 21 that that IN cord-352379-q5inrxcm 118 22 there there EX cord-352379-q5inrxcm 118 23 is be VBZ cord-352379-q5inrxcm 118 24 a a DT cord-352379-q5inrxcm 118 25 hypervariable hypervariable JJ cord-352379-q5inrxcm 118 26 region region NN cord-352379-q5inrxcm 118 27 in in IN cord-352379-q5inrxcm 118 28 S S NNP cord-352379-q5inrxcm 118 29 1 1 CD cord-352379-q5inrxcm 118 30 , , , cord-352379-q5inrxcm 118 31 which which WDT cord-352379-q5inrxcm 118 32 is be VBZ cord-352379-q5inrxcm 118 33 frequently frequently RB cord-352379-q5inrxcm 118 34 mutated mutate VBN cord-352379-q5inrxcm 118 35 or or CC cord-352379-q5inrxcm 118 36 deleted delete VBN cord-352379-q5inrxcm 118 37 in in IN cord-352379-q5inrxcm 118 38 the the DT cord-352379-q5inrxcm 118 39 coronaviruses coronaviruse NNS cord-352379-q5inrxcm 118 40 . . . cord-352379-q5inrxcm 119 1 Such such JJ cord-352379-q5inrxcm 119 2 mutations mutation NNS cord-352379-q5inrxcm 119 3 very very RB cord-352379-q5inrxcm 119 4 often often RB cord-352379-q5inrxcm 119 5 change change VBP cord-352379-q5inrxcm 119 6 the the DT cord-352379-q5inrxcm 119 7 biological biological JJ cord-352379-q5inrxcm 119 8 or or CC cord-352379-q5inrxcm 119 9 pathogenic pathogenic JJ cord-352379-q5inrxcm 119 10 properties property NNS cord-352379-q5inrxcm 119 11 of of IN cord-352379-q5inrxcm 119 12 the the DT cord-352379-q5inrxcm 119 13 virus virus NN cord-352379-q5inrxcm 119 14 . . . cord-352379-q5inrxcm 120 1 The the DT cord-352379-q5inrxcm 120 2 M M NNP cord-352379-q5inrxcm 120 3 and and CC cord-352379-q5inrxcm 120 4 E e NN cord-352379-q5inrxcm 120 5 proteins protein NNS cord-352379-q5inrxcm 120 6 are be VBP cord-352379-q5inrxcm 120 7 the the DT cord-352379-q5inrxcm 120 8 minimum minimum JJ cord-352379-q5inrxcm 120 9 protein protein NN cord-352379-q5inrxcm 120 10 units unit NNS cord-352379-q5inrxcm 120 11 for for IN cord-352379-q5inrxcm 120 12 virus virus NN cord-352379-q5inrxcm 120 13 assembly assembly NN cord-352379-q5inrxcm 120 14 [ [ -LRB- cord-352379-q5inrxcm 120 15 11 11 CD cord-352379-q5inrxcm 120 16 , , , cord-352379-q5inrxcm 120 17 75 75 CD cord-352379-q5inrxcm 120 18 ] ] -RRB- cord-352379-q5inrxcm 120 19 . . . cord-352379-q5inrxcm 121 1 Both both DT cord-352379-q5inrxcm 121 2 are be VBP cord-352379-q5inrxcm 121 3 integral integral JJ cord-352379-q5inrxcm 121 4 membrane membrane NN cord-352379-q5inrxcm 121 5 proteins protein NNS cord-352379-q5inrxcm 121 6 . . . cord-352379-q5inrxcm 122 1 M M NNP cord-352379-q5inrxcm 122 2 protein protein NN cord-352379-q5inrxcm 122 3 resides reside VBZ cord-352379-q5inrxcm 122 4 not not RB cord-352379-q5inrxcm 122 5 only only RB cord-352379-q5inrxcm 122 6 on on IN cord-352379-q5inrxcm 122 7 the the DT cord-352379-q5inrxcm 122 8 viral viral JJ cord-352379-q5inrxcm 122 9 envelope envelope NN cord-352379-q5inrxcm 122 10 , , , cord-352379-q5inrxcm 122 11 but but CC cord-352379-q5inrxcm 122 12 in in IN cord-352379-q5inrxcm 122 13 the the DT cord-352379-q5inrxcm 122 14 viral viral JJ cord-352379-q5inrxcm 122 15 internal internal JJ cord-352379-q5inrxcm 122 16 core core NN cord-352379-q5inrxcm 122 17 as as RB cord-352379-q5inrxcm 122 18 well well RB cord-352379-q5inrxcm 122 19 [ [ -LRB- cord-352379-q5inrxcm 122 20 65 65 CD cord-352379-q5inrxcm 122 21 ] ] -RRB- cord-352379-q5inrxcm 122 22 . . . cord-352379-q5inrxcm 123 1 In in IN cord-352379-q5inrxcm 123 2 the the DT cord-352379-q5inrxcm 123 3 cells cell NNS cord-352379-q5inrxcm 123 4 , , , cord-352379-q5inrxcm 123 5 M M NNP cord-352379-q5inrxcm 123 6 protein protein NN cord-352379-q5inrxcm 123 7 is be VBZ cord-352379-q5inrxcm 123 8 anchored anchor VBN cord-352379-q5inrxcm 123 9 in in IN cord-352379-q5inrxcm 123 10 the the DT cord-352379-q5inrxcm 123 11 Golgi Golgi NNP cord-352379-q5inrxcm 123 12 complex complex NN cord-352379-q5inrxcm 123 13 , , , cord-352379-q5inrxcm 123 14 thus thus RB cord-352379-q5inrxcm 123 15 dictating dictate VBG cord-352379-q5inrxcm 123 16 the the DT cord-352379-q5inrxcm 123 17 site site NN cord-352379-q5inrxcm 123 18 of of IN cord-352379-q5inrxcm 123 19 virus virus NN cord-352379-q5inrxcm 123 20 assembly assembly NN cord-352379-q5inrxcm 123 21 to to IN cord-352379-q5inrxcm 123 22 the the DT cord-352379-q5inrxcm 123 23 ER ER NNP cord-352379-q5inrxcm 123 24 - - HYPH cord-352379-q5inrxcm 123 25 Golgi Golgi NNP cord-352379-q5inrxcm 123 26 complex complex NN cord-352379-q5inrxcm 123 27 [ [ -LRB- cord-352379-q5inrxcm 123 28 73 73 CD cord-352379-q5inrxcm 123 29 ] ] -RRB- cord-352379-q5inrxcm 123 30 . . . cord-352379-q5inrxcm 124 1 The the DT cord-352379-q5inrxcm 124 2 expression expression NN cord-352379-q5inrxcm 124 3 of of IN cord-352379-q5inrxcm 124 4 M M NNP cord-352379-q5inrxcm 124 5 and and CC cord-352379-q5inrxcm 124 6 E e NN cord-352379-q5inrxcm 124 7 proteins protein NNS cord-352379-q5inrxcm 124 8 together together RB cord-352379-q5inrxcm 124 9 is be VBZ cord-352379-q5inrxcm 124 10 sufficient sufficient JJ cord-352379-q5inrxcm 124 11 to to TO cord-352379-q5inrxcm 124 12 trigger trigger VB cord-352379-q5inrxcm 124 13 the the DT cord-352379-q5inrxcm 124 14 formation formation NN cord-352379-q5inrxcm 124 15 of of IN cord-352379-q5inrxcm 124 16 virus virus NN cord-352379-q5inrxcm 124 17 - - HYPH cord-352379-q5inrxcm 124 18 like like JJ cord-352379-q5inrxcm 124 19 particles particle NNS cord-352379-q5inrxcm 124 20 ( ( -LRB- cord-352379-q5inrxcm 124 21 VLP VLP NNP cord-352379-q5inrxcm 124 22 ) ) -RRB- cord-352379-q5inrxcm 124 23 . . . cord-352379-q5inrxcm 125 1 When when WRB cord-352379-q5inrxcm 125 2 S S NNP cord-352379-q5inrxcm 125 3 protein protein NN cord-352379-q5inrxcm 125 4 is be VBZ cord-352379-q5inrxcm 125 5 coexpressed coexpresse VBN cord-352379-q5inrxcm 125 6 with with IN cord-352379-q5inrxcm 125 7 M M NNP cord-352379-q5inrxcm 125 8 and and CC cord-352379-q5inrxcm 125 9 E e NN cord-352379-q5inrxcm 125 10 proteins protein NNS cord-352379-q5inrxcm 125 11 , , , cord-352379-q5inrxcm 125 12 the the DT cord-352379-q5inrxcm 125 13 S S NNP cord-352379-q5inrxcm 125 14 protein protein NN cord-352379-q5inrxcm 125 15 is be VBZ cord-352379-q5inrxcm 125 16 incorporated incorporate VBN cord-352379-q5inrxcm 125 17 into into IN cord-352379-q5inrxcm 125 18 VLP VLP NNP cord-352379-q5inrxcm 125 19 with with IN cord-352379-q5inrxcm 125 20 presumably presumably RB cord-352379-q5inrxcm 125 21 authentic authentic JJ cord-352379-q5inrxcm 125 22 conformation conformation NN cord-352379-q5inrxcm 125 23 . . . cord-352379-q5inrxcm 126 1 Such such JJ cord-352379-q5inrxcm 126 2 a a DT cord-352379-q5inrxcm 126 3 VLP VLP NNP cord-352379-q5inrxcm 126 4 can can MD cord-352379-q5inrxcm 126 5 infect infect VB cord-352379-q5inrxcm 126 6 cells cell NNS cord-352379-q5inrxcm 126 7 [ [ -LRB- cord-352379-q5inrxcm 126 8 11 11 CD cord-352379-q5inrxcm 126 9 ] ] -RRB- cord-352379-q5inrxcm 126 10 . . . cord-352379-q5inrxcm 127 1 Thus thus RB cord-352379-q5inrxcm 127 2 , , , cord-352379-q5inrxcm 127 3 these these DT cord-352379-q5inrxcm 127 4 VI_Ps VI_Ps NNP cord-352379-q5inrxcm 127 5 will will MD cord-352379-q5inrxcm 127 6 be be VB cord-352379-q5inrxcm 127 7 an an DT cord-352379-q5inrxcm 127 8 excellent excellent JJ cord-352379-q5inrxcm 127 9 candidate candidate NN cord-352379-q5inrxcm 127 10 as as IN cord-352379-q5inrxcm 127 11 a a DT cord-352379-q5inrxcm 127 12 potential potential JJ cord-352379-q5inrxcm 127 13 vaccine vaccine NN cord-352379-q5inrxcm 127 14 . . . cord-352379-q5inrxcm 128 1 Intriguingly intriguingly RB cord-352379-q5inrxcm 128 2 , , , cord-352379-q5inrxcm 128 3 it -PRON- PRP cord-352379-q5inrxcm 128 4 has have VBZ cord-352379-q5inrxcm 128 5 recently recently RB cord-352379-q5inrxcm 128 6 been be VBN cord-352379-q5inrxcm 128 7 shown show VBN cord-352379-q5inrxcm 128 8 that that IN cord-352379-q5inrxcm 128 9 E e NN cord-352379-q5inrxcm 128 10 protein protein NN cord-352379-q5inrxcm 128 11 may may MD cord-352379-q5inrxcm 128 12 not not RB cord-352379-q5inrxcm 128 13 be be VB cord-352379-q5inrxcm 128 14 absolutely absolutely RB cord-352379-q5inrxcm 128 15 required require VBN cord-352379-q5inrxcm 128 16 for for IN cord-352379-q5inrxcm 128 17 viral viral JJ cord-352379-q5inrxcm 128 18 infectivity infectivity NN cord-352379-q5inrxcm 128 19 [ [ -LRB- cord-352379-q5inrxcm 128 20 43 43 CD cord-352379-q5inrxcm 128 21 ] ] -RRB- cord-352379-q5inrxcm 128 22 . . . cord-352379-q5inrxcm 129 1 SARS SARS NNP cord-352379-q5inrxcm 129 2 virus virus NN cord-352379-q5inrxcm 129 3 has have VBZ cord-352379-q5inrxcm 129 4 comparable comparable JJ cord-352379-q5inrxcm 129 5 structural structural JJ cord-352379-q5inrxcm 129 6 proteins protein NNS cord-352379-q5inrxcm 129 7 . . . cord-352379-q5inrxcm 130 1 HE HE NNP cord-352379-q5inrxcm 130 2 protein protein NN cord-352379-q5inrxcm 130 3 is be VBZ cord-352379-q5inrxcm 130 4 seen see VBN cord-352379-q5inrxcm 130 5 only only RB cord-352379-q5inrxcm 130 6 in in IN cord-352379-q5inrxcm 130 7 some some DT cord-352379-q5inrxcm 130 8 group group NN cord-352379-q5inrxcm 130 9 II ii CD cord-352379-q5inrxcm 130 10 coronaviruses coronaviruse NNS cord-352379-q5inrxcm 130 11 ; ; : cord-352379-q5inrxcm 130 12 it -PRON- PRP cord-352379-q5inrxcm 130 13 is be VBZ cord-352379-q5inrxcm 130 14 not not RB cord-352379-q5inrxcm 130 15 required require VBN cord-352379-q5inrxcm 130 16 for for IN cord-352379-q5inrxcm 130 17 viral viral JJ cord-352379-q5inrxcm 130 18 infectivity infectivity NN cord-352379-q5inrxcm 130 19 even even RB cord-352379-q5inrxcm 130 20 in in IN cord-352379-q5inrxcm 130 21 those those DT cord-352379-q5inrxcm 130 22 viruses virus NNS cord-352379-q5inrxcm 130 23 ( ( -LRB- cord-352379-q5inrxcm 130 24 e.g. e.g. RB cord-352379-q5inrxcm 130 25 MHV MHV NNP cord-352379-q5inrxcm 130 26 , , , cord-352379-q5inrxcm 130 27 HCoV HCoV NNP cord-352379-q5inrxcm 130 28 - - HYPH cord-352379-q5inrxcm 130 29 OC43 OC43 NNP cord-352379-q5inrxcm 130 30 ) ) -RRB- cord-352379-q5inrxcm 130 31 that that WDT cord-352379-q5inrxcm 130 32 contain contain VBP cord-352379-q5inrxcm 130 33 the the DT cord-352379-q5inrxcm 130 34 HE HE NNP cord-352379-q5inrxcm 130 35 protein protein NN cord-352379-q5inrxcm 130 36 . . . cord-352379-q5inrxcm 131 1 However however RB cord-352379-q5inrxcm 131 2 , , , cord-352379-q5inrxcm 131 3 HE HE NNP cord-352379-q5inrxcm 131 4 protein protein NN cord-352379-q5inrxcm 131 5 may may MD cord-352379-q5inrxcm 131 6 be be VB cord-352379-q5inrxcm 131 7 involved involve VBN cord-352379-q5inrxcm 131 8 in in IN cord-352379-q5inrxcm 131 9 the the DT cord-352379-q5inrxcm 131 10 infection infection NN cord-352379-q5inrxcm 131 11 of of IN cord-352379-q5inrxcm 131 12 BCoV BCoV NNP cord-352379-q5inrxcm 131 13 , , , cord-352379-q5inrxcm 131 14 as as IN cord-352379-q5inrxcm 131 15 a a DT cord-352379-q5inrxcm 131 16 monoclonal monoclonal JJ cord-352379-q5inrxcm 131 17 antibody antibody NN cord-352379-q5inrxcm 131 18 against against IN cord-352379-q5inrxcm 131 19 HE HE NNP cord-352379-q5inrxcm 131 20 protein protein NN cord-352379-q5inrxcm 131 21 can can MD cord-352379-q5inrxcm 131 22 inhibit inhibit VB cord-352379-q5inrxcm 131 23 BCoV BCoV NNP cord-352379-q5inrxcm 131 24 infection infection NN cord-352379-q5inrxcm 131 25 [ [ -LRB- cord-352379-q5inrxcm 131 26 21 21 CD cord-352379-q5inrxcm 131 27 ] ] -RRB- cord-352379-q5inrxcm 131 28 . . . cord-352379-q5inrxcm 132 1 The the DT cord-352379-q5inrxcm 132 2 HE HE NNP cord-352379-q5inrxcm 132 3 protein protein NN cord-352379-q5inrxcm 132 4 binds bind VBZ cord-352379-q5inrxcm 132 5 to to IN cord-352379-q5inrxcm 132 6 certain certain JJ cord-352379-q5inrxcm 132 7 sialic sialic JJ cord-352379-q5inrxcm 132 8 acid acid NN cord-352379-q5inrxcm 132 9 residues residue NNS cord-352379-q5inrxcm 132 10 and and CC cord-352379-q5inrxcm 132 11 possesses possess VBZ cord-352379-q5inrxcm 132 12 an an DT cord-352379-q5inrxcm 132 13 acetyl acetyl NN cord-352379-q5inrxcm 132 14 - - HYPH cord-352379-q5inrxcm 132 15 esterase esterase NN cord-352379-q5inrxcm 132 16 activity activity NN cord-352379-q5inrxcm 132 17 . . . cord-352379-q5inrxcm 133 1 It -PRON- PRP cord-352379-q5inrxcm 133 2 is be VBZ cord-352379-q5inrxcm 133 3 conceivable conceivable JJ cord-352379-q5inrxcm 133 4 that that IN cord-352379-q5inrxcm 133 5 HE HE NNP cord-352379-q5inrxcm 133 6 protein protein NN cord-352379-q5inrxcm 133 7 provides provide VBZ cord-352379-q5inrxcm 133 8 the the DT cord-352379-q5inrxcm 133 9 initial initial JJ cord-352379-q5inrxcm 133 10 binding bind VBG cord-352379-q5inrxcm 133 11 contact contact NN cord-352379-q5inrxcm 133 12 between between IN cord-352379-q5inrxcm 133 13 the the DT cord-352379-q5inrxcm 133 14 virus virus NN cord-352379-q5inrxcm 133 15 and and CC cord-352379-q5inrxcm 133 16 the the DT cord-352379-q5inrxcm 133 17 target target NN cord-352379-q5inrxcm 133 18 cells cell NNS cord-352379-q5inrxcm 133 19 ; ; : cord-352379-q5inrxcm 133 20 however however RB cord-352379-q5inrxcm 133 21 , , , cord-352379-q5inrxcm 133 22 subsequent subsequent JJ cord-352379-q5inrxcm 133 23 tight tight JJ cord-352379-q5inrxcm 133 24 and and CC cord-352379-q5inrxcm 133 25 specific specific JJ cord-352379-q5inrxcm 133 26 binding binding NN cord-352379-q5inrxcm 133 27 may may MD cord-352379-q5inrxcm 133 28 be be VB cord-352379-q5inrxcm 133 29 mediated mediate VBN cord-352379-q5inrxcm 133 30 by by IN cord-352379-q5inrxcm 133 31 the the DT cord-352379-q5inrxcm 133 32 S S NNP cord-352379-q5inrxcm 133 33 protein protein NN cord-352379-q5inrxcm 133 34 . . . cord-352379-q5inrxcm 134 1 HE he PRP cord-352379-q5inrxcm 135 1 protein protein NN cord-352379-q5inrxcm 135 2 bears bear VBZ cord-352379-q5inrxcm 135 3 sequence sequence NN cord-352379-q5inrxcm 135 4 homology homology NN cord-352379-q5inrxcm 135 5 with with IN cord-352379-q5inrxcm 135 6 the the DT cord-352379-q5inrxcm 135 7 hemagglutinin hemagglutinin NN cord-352379-q5inrxcm 135 8 protein protein NN cord-352379-q5inrxcm 135 9 of of IN cord-352379-q5inrxcm 135 10 influenza influenza NN cord-352379-q5inrxcm 135 11 C C NNP cord-352379-q5inrxcm 135 12 virus virus NN cord-352379-q5inrxcm 135 13 , , , cord-352379-q5inrxcm 135 14 thus thus RB cord-352379-q5inrxcm 135 15 prompting prompt VBG cord-352379-q5inrxcm 135 16 suggestions suggestion NNS cord-352379-q5inrxcm 135 17 that that IN cord-352379-q5inrxcm 135 18 recombination recombination NN cord-352379-q5inrxcm 135 19 has have VBZ cord-352379-q5inrxcm 135 20 taken take VBN cord-352379-q5inrxcm 135 21 place place NN cord-352379-q5inrxcm 135 22 between between IN cord-352379-q5inrxcm 135 23 an an DT cord-352379-q5inrxcm 135 24 ancestral ancestral JJ cord-352379-q5inrxcm 135 25 coronavirus coronavirus NN cord-352379-q5inrxcm 135 26 and and CC cord-352379-q5inrxcm 135 27 an an DT cord-352379-q5inrxcm 135 28 influenza influenza NN cord-352379-q5inrxcm 135 29 virus virus NN cord-352379-q5inrxcm 135 30 [ [ -LRB- cord-352379-q5inrxcm 135 31 54 54 CD cord-352379-q5inrxcm 135 32 ] ] -RRB- cord-352379-q5inrxcm 135 33 . . . cord-352379-q5inrxcm 136 1 SARS SARS NNP cord-352379-q5inrxcm 136 2 virus virus NN cord-352379-q5inrxcm 136 3 does do VBZ cord-352379-q5inrxcm 136 4 not not RB cord-352379-q5inrxcm 136 5 encode encode VB cord-352379-q5inrxcm 136 6 the the DT cord-352379-q5inrxcm 136 7 HE HE NNP cord-352379-q5inrxcm 136 8 protein protein NN cord-352379-q5inrxcm 136 9 . . . cord-352379-q5inrxcm 137 1 The the DT cord-352379-q5inrxcm 137 2 final final JJ cord-352379-q5inrxcm 137 3 structural structural JJ cord-352379-q5inrxcm 137 4 protein protein NN cord-352379-q5inrxcm 137 5 is be VBZ cord-352379-q5inrxcm 137 6 N N NNP cord-352379-q5inrxcm 137 7 protein protein NN cord-352379-q5inrxcm 137 8 , , , cord-352379-q5inrxcm 137 9 which which WDT cord-352379-q5inrxcm 137 10 likely likely RB cord-352379-q5inrxcm 137 11 interacts interact VBZ cord-352379-q5inrxcm 137 12 with with IN cord-352379-q5inrxcm 137 13 viral viral JJ cord-352379-q5inrxcm 137 14 RNA RNA NNP cord-352379-q5inrxcm 137 15 and and CC cord-352379-q5inrxcm 137 16 makes make VBZ cord-352379-q5inrxcm 137 17 up up RP cord-352379-q5inrxcm 137 18 the the DT cord-352379-q5inrxcm 137 19 viral viral JJ cord-352379-q5inrxcm 137 20 core core NN cord-352379-q5inrxcm 137 21 and and CC cord-352379-q5inrxcm 137 22 nucleocapsid nucleocapsid NN cord-352379-q5inrxcm 137 23 . . . cord-352379-q5inrxcm 138 1 It -PRON- PRP cord-352379-q5inrxcm 138 2 is be VBZ cord-352379-q5inrxcm 138 3 interesting interesting JJ cord-352379-q5inrxcm 138 4 to to TO cord-352379-q5inrxcm 138 5 note note VB cord-352379-q5inrxcm 138 6 that that IN cord-352379-q5inrxcm 138 7 the the DT cord-352379-q5inrxcm 138 8 coronavirus coronavirus NN cord-352379-q5inrxcm 138 9 particles particle NNS cord-352379-q5inrxcm 138 10 appear appear VBP cord-352379-q5inrxcm 138 11 to to TO cord-352379-q5inrxcm 138 12 include include VB cord-352379-q5inrxcm 138 13 both both CC cord-352379-q5inrxcm 138 14 an an DT cord-352379-q5inrxcm 138 15 icosahedral icosahedral JJ cord-352379-q5inrxcm 138 16 core core NN cord-352379-q5inrxcm 138 17 and and CC cord-352379-q5inrxcm 138 18 an an DT cord-352379-q5inrxcm 138 19 internal internal JJ cord-352379-q5inrxcm 138 20 helical helical JJ cord-352379-q5inrxcm 138 21 nucteocapsid nucteocapsid JJS cord-352379-q5inrxcm 138 22 [ [ -LRB- cord-352379-q5inrxcm 138 23 65 65 CD cord-352379-q5inrxcm 138 24 ] ] -RRB- cord-352379-q5inrxcm 138 25 . . . cord-352379-q5inrxcm 139 1 N n NN cord-352379-q5inrxcm 139 2 protein protein NN cord-352379-q5inrxcm 139 3 is be VBZ cord-352379-q5inrxcm 139 4 present present JJ cord-352379-q5inrxcm 139 5 in in IN cord-352379-q5inrxcm 139 6 both both DT cord-352379-q5inrxcm 139 7 structures structure NNS cord-352379-q5inrxcm 139 8 . . . cord-352379-q5inrxcm 140 1 SARS SARS NNP cord-352379-q5inrxcm 140 2 virus virus NN cord-352379-q5inrxcm 140 3 has have VBZ cord-352379-q5inrxcm 140 4 typical typical JJ cord-352379-q5inrxcm 140 5 N N NNP cord-352379-q5inrxcm 140 6 protein protein NN cord-352379-q5inrxcm 140 7 structural structural JJ cord-352379-q5inrxcm 140 8 motifs motif NNS cord-352379-q5inrxcm 140 9 , , , cord-352379-q5inrxcm 140 10 including include VBG cord-352379-q5inrxcm 140 11 several several JJ cord-352379-q5inrxcm 140 12 RNA RNA NNP cord-352379-q5inrxcm 140 13 - - HYPH cord-352379-q5inrxcm 140 14 binding bind VBG cord-352379-q5inrxcm 140 15 domains domain NNS cord-352379-q5inrxcm 140 16 . . . cord-352379-q5inrxcm 141 1 Coronaviruses coronaviruse NNS cord-352379-q5inrxcm 141 2 have have VBP cord-352379-q5inrxcm 141 3 an an DT cord-352379-q5inrxcm 141 4 envelope envelope NN cord-352379-q5inrxcm 141 5 that that WDT cord-352379-q5inrxcm 141 6 reflects reflect VBZ cord-352379-q5inrxcm 141 7 the the DT cord-352379-q5inrxcm 141 8 lipid lipid NN cord-352379-q5inrxcm 141 9 composition composition NN cord-352379-q5inrxcm 141 10 of of IN cord-352379-q5inrxcm 141 11 the the DT cord-352379-q5inrxcm 141 12 cellular cellular JJ cord-352379-q5inrxcm 141 13 membranes membrane NNS cord-352379-q5inrxcm 141 14 . . . cord-352379-q5inrxcm 142 1 However however RB cord-352379-q5inrxcm 142 2 , , , cord-352379-q5inrxcm 142 3 remarkably remarkably RB cord-352379-q5inrxcm 142 4 , , , cord-352379-q5inrxcm 142 5 coronavirus coronavirus NN cord-352379-q5inrxcm 142 6 is be VBZ cord-352379-q5inrxcm 142 7 one one CD cord-352379-q5inrxcm 142 8 of of IN cord-352379-q5inrxcm 142 9 the the DT cord-352379-q5inrxcm 142 10 very very RB cord-352379-q5inrxcm 142 11 few few JJ cord-352379-q5inrxcm 142 12 enveloped envelop VBN cord-352379-q5inrxcm 142 13 viruses virus NNS cord-352379-q5inrxcm 142 14 that that WDT cord-352379-q5inrxcm 142 15 are be VBP cord-352379-q5inrxcm 142 16 able able JJ cord-352379-q5inrxcm 142 17 to to TO cord-352379-q5inrxcm 142 18 cause cause VB cord-352379-q5inrxcm 142 19 enteric enteric JJ cord-352379-q5inrxcm 142 20 infections infection NNS cord-352379-q5inrxcm 142 21 . . . cord-352379-q5inrxcm 143 1 Thus thus RB cord-352379-q5inrxcm 143 2 , , , cord-352379-q5inrxcm 143 3 the the DT cord-352379-q5inrxcm 143 4 viral viral JJ cord-352379-q5inrxcm 143 5 envelope envelope NN cord-352379-q5inrxcm 143 6 certainly certainly RB cord-352379-q5inrxcm 143 7 can can MD cord-352379-q5inrxcm 143 8 resist resist VB cord-352379-q5inrxcm 143 9 the the DT cord-352379-q5inrxcm 143 10 harsh harsh JJ cord-352379-q5inrxcm 143 11 environment environment NN cord-352379-q5inrxcm 143 12 of of IN cord-352379-q5inrxcm 143 13 the the DT cord-352379-q5inrxcm 143 14 gastrointestinal gastrointestinal JJ cord-352379-q5inrxcm 143 15 tract tract NN cord-352379-q5inrxcm 143 16 , , , cord-352379-q5inrxcm 143 17 namely namely RB cord-352379-q5inrxcm 143 18 , , , cord-352379-q5inrxcm 143 19 the the DT cord-352379-q5inrxcm 143 20 acidic acidic JJ cord-352379-q5inrxcm 143 21 environment environment NN cord-352379-q5inrxcm 143 22 of of IN cord-352379-q5inrxcm 143 23 the the DT cord-352379-q5inrxcm 143 24 stomach stomach NN cord-352379-q5inrxcm 143 25 and and CC cord-352379-q5inrxcm 143 26 the the DT cord-352379-q5inrxcm 143 27 bile bile NN cord-352379-q5inrxcm 143 28 and and CC cord-352379-q5inrxcm 143 29 lytic lytic JJ cord-352379-q5inrxcm 143 30 enzymes enzyme NNS cord-352379-q5inrxcm 143 31 of of IN cord-352379-q5inrxcm 143 32 the the DT cord-352379-q5inrxcm 143 33 small small JJ cord-352379-q5inrxcm 143 34 intestines intestine NNS cord-352379-q5inrxcm 143 35 . . . cord-352379-q5inrxcm 144 1 The the DT cord-352379-q5inrxcm 144 2 structural structural JJ cord-352379-q5inrxcm 144 3 and and CC cord-352379-q5inrxcm 144 4 chemical chemical JJ cord-352379-q5inrxcm 144 5 basis basis NN cord-352379-q5inrxcm 144 6 for for IN cord-352379-q5inrxcm 144 7 such such JJ cord-352379-q5inrxcm 144 8 unusual unusual JJ cord-352379-q5inrxcm 144 9 resistance resistance NN cord-352379-q5inrxcm 144 10 is be VBZ cord-352379-q5inrxcm 144 11 not not RB cord-352379-q5inrxcm 144 12 yet yet RB cord-352379-q5inrxcm 144 13 clear clear JJ cord-352379-q5inrxcm 144 14 . . . cord-352379-q5inrxcm 145 1 Correspondingly correspondingly RB cord-352379-q5inrxcm 145 2 , , , cord-352379-q5inrxcm 145 3 SARS SARS NNP cord-352379-q5inrxcm 145 4 patients patient NNS cord-352379-q5inrxcm 145 5 very very RB cord-352379-q5inrxcm 145 6 often often RB cord-352379-q5inrxcm 145 7 show show VBP cord-352379-q5inrxcm 145 8 GI GI NNP cord-352379-q5inrxcm 145 9 symptoms symptom NNS cord-352379-q5inrxcm 145 10 , , , cord-352379-q5inrxcm 145 11 and and CC cord-352379-q5inrxcm 145 12 the the DT cord-352379-q5inrxcm 145 13 virus virus NN cord-352379-q5inrxcm 145 14 is be VBZ cord-352379-q5inrxcm 145 15 usually usually RB cord-352379-q5inrxcm 145 16 detected detect VBN cord-352379-q5inrxcm 145 17 in in IN cord-352379-q5inrxcm 145 18 the the DT cord-352379-q5inrxcm 145 19 stool stool NN cord-352379-q5inrxcm 145 20 [ [ -LRB- cord-352379-q5inrxcm 145 21 62 62 CD cord-352379-q5inrxcm 145 22 ] ] -RRB- cord-352379-q5inrxcm 145 23 . . . cord-352379-q5inrxcm 146 1 Therefore therefore RB cord-352379-q5inrxcm 146 2 , , , cord-352379-q5inrxcm 146 3 the the DT cord-352379-q5inrxcm 146 4 envelope envelope NN cord-352379-q5inrxcm 146 5 of of IN cord-352379-q5inrxcm 146 6 SARS SARS NNP cord-352379-q5inrxcm 146 7 virus virus NN cord-352379-q5inrxcm 146 8 likely likely RB cord-352379-q5inrxcm 146 9 consists consist VBZ cord-352379-q5inrxcm 146 10 of of IN cord-352379-q5inrxcm 146 11 unusual unusual JJ cord-352379-q5inrxcm 146 12 structures structure NNS cord-352379-q5inrxcm 146 13 . . . cord-352379-q5inrxcm 147 1 Indeed indeed RB cord-352379-q5inrxcm 147 2 , , , cord-352379-q5inrxcm 147 3 it -PRON- PRP cord-352379-q5inrxcm 147 4 has have VBZ cord-352379-q5inrxcm 147 5 been be VBN cord-352379-q5inrxcm 147 6 shown show VBN cord-352379-q5inrxcm 147 7 that that IN cord-352379-q5inrxcm 147 8 SARS SARS NNP cord-352379-q5inrxcm 147 9 virus virus NN cord-352379-q5inrxcm 147 10 can can MD cord-352379-q5inrxcm 147 11 survive survive VB cord-352379-q5inrxcm 147 12 in in IN cord-352379-q5inrxcm 147 13 diarrheal diarrheal JJ cord-352379-q5inrxcm 147 14 stool stool NN cord-352379-q5inrxcm 147 15 for for IN cord-352379-q5inrxcm 147 16 as as RB cord-352379-q5inrxcm 147 17 long long JJ cord-352379-q5inrxcm 147 18 as as IN cord-352379-q5inrxcm 147 19 4 4 CD cord-352379-q5inrxcm 147 20 days day NNS cord-352379-q5inrxcm 147 21 and and CC cord-352379-q5inrxcm 147 22 on on IN cord-352379-q5inrxcm 147 23 a a DT cord-352379-q5inrxcm 147 24 dry dry JJ cord-352379-q5inrxcm 147 25 surface surface NN cord-352379-q5inrxcm 147 26 for for IN cord-352379-q5inrxcm 147 27 24 24 CD cord-352379-q5inrxcm 147 28 h h NN cord-352379-q5inrxcm 147 29 ( ( -LRB- cord-352379-q5inrxcm 147 30 World World NNP cord-352379-q5inrxcm 147 31 Health Health NNP cord-352379-q5inrxcm 147 32 Organization Organization NNP cord-352379-q5inrxcm 147 33 Bulletin Bulletin NNP cord-352379-q5inrxcm 147 34 ) ) -RRB- cord-352379-q5inrxcm 147 35 . . . cord-352379-q5inrxcm 148 1 These these DT cord-352379-q5inrxcm 148 2 unusual unusual JJ cord-352379-q5inrxcm 148 3 envelope envelope NN cord-352379-q5inrxcm 148 4 properties property NNS cord-352379-q5inrxcm 148 5 have have VBP cord-352379-q5inrxcm 148 6 implications implication NNS cord-352379-q5inrxcm 148 7 for for IN cord-352379-q5inrxcm 148 8 the the DT cord-352379-q5inrxcm 148 9 control control NN cord-352379-q5inrxcm 148 10 of of IN cord-352379-q5inrxcm 148 11 the the DT cord-352379-q5inrxcm 148 12 SARS SARS NNP cord-352379-q5inrxcm 148 13 outbreaks outbreak NNS cord-352379-q5inrxcm 148 14 . . . cord-352379-q5inrxcm 149 1 As as IN cord-352379-q5inrxcm 149 2 an an DT cord-352379-q5inrxcm 149 3 RNA RNA NNP cord-352379-q5inrxcm 149 4 virus virus NN cord-352379-q5inrxcm 149 5 , , , cord-352379-q5inrxcm 149 6 SARS SARS NNP cord-352379-q5inrxcm 149 7 virus virus NN cord-352379-q5inrxcm 149 8 can can MD cord-352379-q5inrxcm 149 9 be be VB cord-352379-q5inrxcm 149 10 expected expect VBN cord-352379-q5inrxcm 149 11 to to TO cord-352379-q5inrxcm 149 12 undergo undergo VB cord-352379-q5inrxcm 149 13 mutation mutation NN cord-352379-q5inrxcm 149 14 at at IN cord-352379-q5inrxcm 149 15 a a DT cord-352379-q5inrxcm 149 16 very very RB cord-352379-q5inrxcm 149 17 high high JJ cord-352379-q5inrxcm 149 18 frequency frequency NN cord-352379-q5inrxcm 149 19 . . . cord-352379-q5inrxcm 150 1 With with IN cord-352379-q5inrxcm 150 2 an an DT cord-352379-q5inrxcm 150 3 estimated estimate VBN cord-352379-q5inrxcm 150 4 error error NN cord-352379-q5inrxcm 150 5 frequency frequency NN cord-352379-q5inrxcm 150 6 of of IN cord-352379-q5inrxcm 150 7 1 1 CD cord-352379-q5inrxcm 150 8 x x SYM cord-352379-q5inrxcm 150 9 10 10 CD cord-352379-q5inrxcm 150 10 .4 .4 CD cord-352379-q5inrxcm 150 11 for for IN cord-352379-q5inrxcm 150 12 RNA RNA NNP cord-352379-q5inrxcm 150 13 - - HYPH cord-352379-q5inrxcm 150 14 dependent dependent JJ cord-352379-q5inrxcm 150 15 RNA RNA NNP cord-352379-q5inrxcm 150 16 polymerases polymerase NNS cord-352379-q5inrxcm 150 17 in in IN cord-352379-q5inrxcm 150 18 general general JJ cord-352379-q5inrxcm 150 19 , , , cord-352379-q5inrxcm 150 20 the the DT cord-352379-q5inrxcm 150 21 SARS SARS NNP cord-352379-q5inrxcm 150 22 virus virus NN cord-352379-q5inrxcm 150 23 genome genome NN cord-352379-q5inrxcm 150 24 can can MD cord-352379-q5inrxcm 150 25 be be VB cord-352379-q5inrxcm 150 26 expected expect VBN cord-352379-q5inrxcm 150 27 to to TO cord-352379-q5inrxcm 150 28 accumulate accumulate VB cord-352379-q5inrxcm 150 29 an an DT cord-352379-q5inrxcm 150 30 average average NN cord-352379-q5inrxcm 150 31 of of IN cord-352379-q5inrxcm 150 32 three three CD cord-352379-q5inrxcm 150 33 mutations mutation NNS cord-352379-q5inrxcm 150 34 per per IN cord-352379-q5inrxcm 150 35 round round NN cord-352379-q5inrxcm 150 36 of of IN cord-352379-q5inrxcm 150 37 RNA RNA NNP cord-352379-q5inrxcm 150 38 replication replication NN cord-352379-q5inrxcm 150 39 . . . cord-352379-q5inrxcm 151 1 Thus thus RB cord-352379-q5inrxcm 151 2 , , , cord-352379-q5inrxcm 151 3 SARS SARS NNP cord-352379-q5inrxcm 151 4 virus virus NN cord-352379-q5inrxcm 151 5 , , , cord-352379-q5inrxcm 151 6 like like IN cord-352379-q5inrxcm 151 7 all all DT cord-352379-q5inrxcm 151 8 other other JJ cord-352379-q5inrxcm 151 9 RNA RNA NNP cord-352379-q5inrxcm 151 10 viruses virus NNS cord-352379-q5inrxcm 151 11 , , , cord-352379-q5inrxcm 151 12 probably probably RB cord-352379-q5inrxcm 151 13 consists consist VBZ cord-352379-q5inrxcm 151 14 of of IN cord-352379-q5inrxcm 151 15 a a DT cord-352379-q5inrxcm 151 16 collection collection NN cord-352379-q5inrxcm 151 17 of of IN cord-352379-q5inrxcm 151 18 RNA RNA NNP cord-352379-q5inrxcm 151 19 quasispecies quasispecies NNP cord-352379-q5inrxcm 151 20 [ [ -LRB- cord-352379-q5inrxcm 151 21 23 23 CD cord-352379-q5inrxcm 151 22 ] ] -RRB- cord-352379-q5inrxcm 151 23 . . . cord-352379-q5inrxcm 152 1 Such such PDT cord-352379-q5inrxcm 152 2 a a DT cord-352379-q5inrxcm 152 3 high high JJ cord-352379-q5inrxcm 152 4 frequency frequency NN cord-352379-q5inrxcm 152 5 of of IN cord-352379-q5inrxcm 152 6 mutation mutation NN cord-352379-q5inrxcm 152 7 implies imply VBZ cord-352379-q5inrxcm 152 8 that that IN cord-352379-q5inrxcm 152 9 the the DT cord-352379-q5inrxcm 152 10 tkNA tkNA NNP cord-352379-q5inrxcm 152 11 viral viral JJ cord-352379-q5inrxcm 152 12 genome genome NN cord-352379-q5inrxcm 152 13 is be VBZ cord-352379-q5inrxcm 152 14 inherently inherently RB cord-352379-q5inrxcm 152 15 limited limit VBN cord-352379-q5inrxcm 152 16 in in IN cord-352379-q5inrxcm 152 17 size size NN cord-352379-q5inrxcm 152 18 . . . cord-352379-q5inrxcm 153 1 Coronaviruses coronaviruse NNS cord-352379-q5inrxcm 153 2 are be VBP cord-352379-q5inrxcm 153 3 obvious obvious JJ cord-352379-q5inrxcm 153 4 aberrations aberration NNS cord-352379-q5inrxcm 153 5 . . . cord-352379-q5inrxcm 154 1 Yet yet RB cord-352379-q5inrxcm 154 2 , , , cord-352379-q5inrxcm 154 3 despite despite IN cord-352379-q5inrxcm 154 4 having have VBG cord-352379-q5inrxcm 154 5 an an DT cord-352379-q5inrxcm 154 6 extraordinarily extraordinarily RB cord-352379-q5inrxcm 154 7 long long JJ cord-352379-q5inrxcm 154 8 RNA RNA NNP cord-352379-q5inrxcm 154 9 genome genome NN cord-352379-q5inrxcm 154 10 , , , cord-352379-q5inrxcm 154 11 SARS SARS NNP cord-352379-q5inrxcm 154 12 virus virus NN cord-352379-q5inrxcm 154 13 and and CC cord-352379-q5inrxcm 154 14 other other JJ cord-352379-q5inrxcm 154 15 coronaviruses coronaviruse NNS cord-352379-q5inrxcm 154 16 appear appear VBP cord-352379-q5inrxcm 154 17 to to TO cord-352379-q5inrxcm 154 18 be be VB cord-352379-q5inrxcm 154 19 relatively relatively RB cord-352379-q5inrxcm 154 20 genetically genetically RB cord-352379-q5inrxcm 154 21 stable stable JJ cord-352379-q5inrxcm 154 22 . . . cord-352379-q5inrxcm 155 1 To to IN cord-352379-q5inrxcm 155 2 date date NN cord-352379-q5inrxcm 155 3 , , , cord-352379-q5inrxcm 155 4 the the DT cord-352379-q5inrxcm 155 5 predominant predominant JJ cord-352379-q5inrxcm 155 6 RNA RNA NNP cord-352379-q5inrxcm 155 7 species specie NNS cord-352379-q5inrxcm 155 8 from from IN cord-352379-q5inrxcm 155 9 different different JJ cord-352379-q5inrxcm 155 10 SARS SARS NNP cord-352379-q5inrxcm 155 11 patients patient NNS cord-352379-q5inrxcm 155 12 appear appear VBP cord-352379-q5inrxcm 155 13 to to TO cord-352379-q5inrxcm 155 14 be be VB cord-352379-q5inrxcm 155 15 quite quite RB cord-352379-q5inrxcm 155 16 homogeneous homogeneous JJ cord-352379-q5inrxcm 155 17 . . . cord-352379-q5inrxcm 156 1 The the DT cord-352379-q5inrxcm 156 2 various various JJ cord-352379-q5inrxcm 156 3 SARS SARS NNP cord-352379-q5inrxcm 156 4 virus virus NN cord-352379-q5inrxcm 156 5 isolates isolate VBZ cord-352379-q5inrxcm 156 6 from from IN cord-352379-q5inrxcm 156 7 different different JJ cord-352379-q5inrxcm 156 8 geographical geographical JJ cord-352379-q5inrxcm 156 9 regions region NNS cord-352379-q5inrxcm 156 10 differ differ VBP cord-352379-q5inrxcm 156 11 by by IN cord-352379-q5inrxcm 156 12 no no DT cord-352379-q5inrxcm 156 13 more more JJR cord-352379-q5inrxcm 156 14 than than IN cord-352379-q5inrxcm 156 15 ten ten CD cord-352379-q5inrxcm 156 16 amino amino NN cord-352379-q5inrxcm 156 17 acids acid NNS cord-352379-q5inrxcm 156 18 in in IN cord-352379-q5inrxcm 156 19 the the DT cord-352379-q5inrxcm 156 20 entire entire JJ cord-352379-q5inrxcm 156 21 genome genome NN cord-352379-q5inrxcm 156 22 . . . cord-352379-q5inrxcm 157 1 It -PRON- PRP cord-352379-q5inrxcm 157 2 is be VBZ cord-352379-q5inrxcm 157 3 not not RB cord-352379-q5inrxcm 157 4 clear clear JJ cord-352379-q5inrxcm 157 5 whether whether IN cord-352379-q5inrxcm 157 6 these these DT cord-352379-q5inrxcm 157 7 differences difference NNS cord-352379-q5inrxcm 157 8 confer confer VBP cord-352379-q5inrxcm 157 9 any any DT cord-352379-q5inrxcm 157 10 differences difference NNS cord-352379-q5inrxcm 157 11 in in IN cord-352379-q5inrxcm 157 12 the the DT cord-352379-q5inrxcm 157 13 biological biological JJ cord-352379-q5inrxcm 157 14 properties property NNS cord-352379-q5inrxcm 157 15 of of IN cord-352379-q5inrxcm 157 16 the the DT cord-352379-q5inrxcm 157 17 virus virus NN cord-352379-q5inrxcm 157 18 . . . cord-352379-q5inrxcm 158 1 Nevertheless nevertheless RB cord-352379-q5inrxcm 158 2 , , , cord-352379-q5inrxcm 158 3 they -PRON- PRP cord-352379-q5inrxcm 158 4 allow allow VBP cord-352379-q5inrxcm 158 5 epidemiological epidemiological JJ cord-352379-q5inrxcm 158 6 tracing tracing NN cord-352379-q5inrxcm 158 7 of of IN cord-352379-q5inrxcm 158 8 the the DT cord-352379-q5inrxcm 158 9 virus virus NN cord-352379-q5inrxcm 158 10 transmission transmission NN cord-352379-q5inrxcm 158 11 routes route NNS cord-352379-q5inrxcm 158 12 . . . cord-352379-q5inrxcm 159 1 It -PRON- PRP cord-352379-q5inrxcm 159 2 appears appear VBZ cord-352379-q5inrxcm 159 3 that that IN cord-352379-q5inrxcm 159 4 two two CD cord-352379-q5inrxcm 159 5 different different JJ cord-352379-q5inrxcm 159 6 lineages lineage NNS cord-352379-q5inrxcm 159 7 of of IN cord-352379-q5inrxcm 159 8 the the DT cord-352379-q5inrxcm 159 9 SARS SARS NNP cord-352379-q5inrxcm 159 10 virus virus NN cord-352379-q5inrxcm 159 11 can can MD cord-352379-q5inrxcm 159 12 be be VB cord-352379-q5inrxcm 159 13 independently independently RB cord-352379-q5inrxcm 159 14 traced trace VBN cord-352379-q5inrxcm 159 15 [ [ -LRB- cord-352379-q5inrxcm 159 16 67 67 CD cord-352379-q5inrxcm 159 17 ] ] -RRB- cord-352379-q5inrxcm 159 18 . . . cord-352379-q5inrxcm 160 1 Whether whether IN cord-352379-q5inrxcm 160 2 the the DT cord-352379-q5inrxcm 160 3 virus virus NN cord-352379-q5inrxcm 160 4 will will MD cord-352379-q5inrxcm 160 5 undergo undergo VB cord-352379-q5inrxcm 160 6 a a DT cord-352379-q5inrxcm 160 7 higher high JJR cord-352379-q5inrxcm 160 8 frequency frequency NN cord-352379-q5inrxcm 160 9 of of IN cord-352379-q5inrxcm 160 10 mutation mutation NN cord-352379-q5inrxcm 160 11 in in IN cord-352379-q5inrxcm 160 12 the the DT cord-352379-q5inrxcm 160 13 future future NN cord-352379-q5inrxcm 160 14 once once IN cord-352379-q5inrxcm 160 15 seasonal seasonal JJ cord-352379-q5inrxcm 160 16 changes change NNS cord-352379-q5inrxcm 160 17 occur occur VBP cord-352379-q5inrxcm 160 18 or or CC cord-352379-q5inrxcm 160 19 after after IN cord-352379-q5inrxcm 160 20 specific specific JJ cord-352379-q5inrxcm 160 21 drug drug NN cord-352379-q5inrxcm 160 22 treatments treatment NNS cord-352379-q5inrxcm 160 23 are be VBP cord-352379-q5inrxcm 160 24 introduced introduce VBN cord-352379-q5inrxcm 160 25 is be VBZ cord-352379-q5inrxcm 160 26 an an DT cord-352379-q5inrxcm 160 27 issue issue NN cord-352379-q5inrxcm 160 28 of of IN cord-352379-q5inrxcm 160 29 concern concern NN cord-352379-q5inrxcm 160 30 . . . cord-352379-q5inrxcm 161 1 However however RB cord-352379-q5inrxcm 161 2 , , , cord-352379-q5inrxcm 161 3 there there EX cord-352379-q5inrxcm 161 4 has have VBZ cord-352379-q5inrxcm 161 5 been be VBN cord-352379-q5inrxcm 161 6 no no DT cord-352379-q5inrxcm 161 7 investigation investigation NN cord-352379-q5inrxcm 161 8 of of IN cord-352379-q5inrxcm 161 9 the the DT cord-352379-q5inrxcm 161 10 nature nature NN cord-352379-q5inrxcm 161 11 of of IN cord-352379-q5inrxcm 161 12 RNA RNA NNP cord-352379-q5inrxcm 161 13 quasispecies quasispecie NNS cord-352379-q5inrxcm 161 14 of of IN cord-352379-q5inrxcm 161 15 SARS SARS NNP cord-352379-q5inrxcm 161 16 virus virus NN cord-352379-q5inrxcm 161 17 derived derive VBN cord-352379-q5inrxcm 161 18 from from IN cord-352379-q5inrxcm 161 19 different different JJ cord-352379-q5inrxcm 161 20 patients patient NNS cord-352379-q5inrxcm 161 21 so so RB cord-352379-q5inrxcm 161 22 far far RB cord-352379-q5inrxcm 161 23 . . . cord-352379-q5inrxcm 162 1 Such such JJ cord-352379-q5inrxcm 162 2 RNA RNA NNP cord-352379-q5inrxcm 162 3 quasispecies quasispecie NNS cord-352379-q5inrxcm 162 4 may may MD cord-352379-q5inrxcm 162 5 represent represent VB cord-352379-q5inrxcm 162 6 potential potential JJ cord-352379-q5inrxcm 162 7 sources source NNS cord-352379-q5inrxcm 162 8 of of IN cord-352379-q5inrxcm 162 9 viral viral JJ cord-352379-q5inrxcm 162 10 divergence divergence NN cord-352379-q5inrxcm 162 11 . . . cord-352379-q5inrxcm 163 1 Coronaviruses coronaviruse NNS cord-352379-q5inrxcm 163 2 have have VBP cord-352379-q5inrxcm 163 3 another another DT cord-352379-q5inrxcm 163 4 powerful powerful JJ cord-352379-q5inrxcm 163 5 genetic genetic JJ cord-352379-q5inrxcm 163 6 means mean NNS cord-352379-q5inrxcm 163 7 for for IN cord-352379-q5inrxcm 163 8 evolution evolution NN cord-352379-q5inrxcm 163 9 : : : cord-352379-q5inrxcm 163 10 RNA RNA NNP cord-352379-q5inrxcm 163 11 recombination recombination NN cord-352379-q5inrxcm 163 12 , , , cord-352379-q5inrxcm 163 13 which which WDT cord-352379-q5inrxcm 163 14 occurs occur VBZ cord-352379-q5inrxcm 163 15 at at IN cord-352379-q5inrxcm 163 16 a a DT cord-352379-q5inrxcm 163 17 very very RB cord-352379-q5inrxcm 163 18 high high JJ cord-352379-q5inrxcm 163 19 frequency frequency NN cord-352379-q5inrxcm 163 20 [ [ -LRB- cord-352379-q5inrxcm 163 21 46 46 CD cord-352379-q5inrxcm 163 22 ] ] -RRB- cord-352379-q5inrxcm 163 23 . . . cord-352379-q5inrxcm 164 1 In in IN cord-352379-q5inrxcm 164 2 theory theory NN cord-352379-q5inrxcm 164 3 , , , cord-352379-q5inrxcm 164 4 recombination recombination NN cord-352379-q5inrxcm 164 5 may may MD cord-352379-q5inrxcm 164 6 not not RB cord-352379-q5inrxcm 164 7 only only RB cord-352379-q5inrxcm 164 8 introduce introduce VB cord-352379-q5inrxcm 164 9 genome genome NN cord-352379-q5inrxcm 164 10 alterations alteration NNS cord-352379-q5inrxcm 164 11 but but CC cord-352379-q5inrxcm 164 12 , , , cord-352379-q5inrxcm 164 13 paradoxically paradoxically RB cord-352379-q5inrxcm 164 14 , , , cord-352379-q5inrxcm 164 15 balance balance VB cord-352379-q5inrxcm 164 16 the the DT cord-352379-q5inrxcm 164 17 deleterious deleterious JJ cord-352379-q5inrxcm 164 18 effects effect NNS cord-352379-q5inrxcm 164 19 of of IN cord-352379-q5inrxcm 164 20 mutations mutation NNS cord-352379-q5inrxcm 164 21 by by IN cord-352379-q5inrxcm 164 22 removing remove VBG cord-352379-q5inrxcm 164 23 the the DT cord-352379-q5inrxcm 164 24 undesirable undesirable JJ cord-352379-q5inrxcm 164 25 defects defect NNS cord-352379-q5inrxcm 164 26 [ [ -LRB- cord-352379-q5inrxcm 164 27 47 47 CD cord-352379-q5inrxcm 164 28 ] ] -RRB- cord-352379-q5inrxcm 164 29 . . . cord-352379-q5inrxcm 165 1 This this DT cord-352379-q5inrxcm 165 2 ability ability NN cord-352379-q5inrxcm 165 3 may may MD cord-352379-q5inrxcm 165 4 explain explain VB cord-352379-q5inrxcm 165 5 why why WRB cord-352379-q5inrxcm 165 6 coronavirus coronavirus NN cord-352379-q5inrxcm 165 7 can can MD cord-352379-q5inrxcm 165 8 maintain maintain VB cord-352379-q5inrxcm 165 9 such such PDT cord-352379-q5inrxcm 165 10 a a DT cord-352379-q5inrxcm 165 11 long long JJ cord-352379-q5inrxcm 165 12 RNA RNA NNP cord-352379-q5inrxcm 165 13 genome genome NN cord-352379-q5inrxcm 165 14 . . . cord-352379-q5inrxcm 166 1 The the DT cord-352379-q5inrxcm 166 2 ability ability NN cord-352379-q5inrxcm 166 3 of of IN cord-352379-q5inrxcm 166 4 coronaviruses coronaviruse NNS cord-352379-q5inrxcm 166 5 to to TO cord-352379-q5inrxcm 166 6 recombine recombine VB cord-352379-q5inrxcm 166 7 may may MD cord-352379-q5inrxcm 166 8 stem stem VB cord-352379-q5inrxcm 166 9 from from IN cord-352379-q5inrxcm 166 10 the the DT cord-352379-q5inrxcm 166 11 nonprocessive nonprocessive JJ cord-352379-q5inrxcm 166 12 nature nature NN cord-352379-q5inrxcm 166 13 of of IN cord-352379-q5inrxcm 166 14 coronavirus coronavirus NN cord-352379-q5inrxcm 166 15 RNA rna NN cord-352379-q5inrxcm 166 16 polymerase polymerase NN cord-352379-q5inrxcm 166 17 , , , cord-352379-q5inrxcm 166 18 which which WDT cord-352379-q5inrxcm 166 19 mediates mediate VBZ cord-352379-q5inrxcm 166 20 discontinuous discontinuous JJ cord-352379-q5inrxcm 166 21 RNA RNA NNP cord-352379-q5inrxcm 166 22 synthesis synthesis NN cord-352379-q5inrxcm 166 23 during during IN cord-352379-q5inrxcm 166 24 mRNA mRNA NNP cord-352379-q5inrxcm 166 25 transcription transcription NNP cord-352379-q5inrxcm 166 26 [ [ -LRB- cord-352379-q5inrxcm 166 27 49 49 CD cord-352379-q5inrxcm 166 28 ] ] -RRB- cord-352379-q5inrxcm 166 29 . . . cord-352379-q5inrxcm 167 1 In in IN cord-352379-q5inrxcm 167 2 natural natural JJ cord-352379-q5inrxcm 167 3 infections infection NNS cord-352379-q5inrxcm 167 4 , , , cord-352379-q5inrxcm 167 5 both both DT cord-352379-q5inrxcm 167 6 mutation mutation NN cord-352379-q5inrxcm 167 7 and and CC cord-352379-q5inrxcm 167 8 recombination recombination NN cord-352379-q5inrxcm 167 9 have have VBP cord-352379-q5inrxcm 167 10 been be VBN cord-352379-q5inrxcm 167 11 demonstrated demonstrate VBN cord-352379-q5inrxcm 167 12 to to TO cord-352379-q5inrxcm 167 13 contribute contribute VB cord-352379-q5inrxcm 167 14 to to IN cord-352379-q5inrxcm 167 15 the the DT cord-352379-q5inrxcm 167 16 evolution evolution NN cord-352379-q5inrxcm 167 17 of of IN cord-352379-q5inrxcm 167 18 the the DT cord-352379-q5inrxcm 167 19 coronaviruses coronaviruse NNS cord-352379-q5inrxcm 167 20 . . . cord-352379-q5inrxcm 168 1 Avian avian JJ cord-352379-q5inrxcm 168 2 coronavirus coronavirus NN cord-352379-q5inrxcm 168 3 IBV IBV NNP cord-352379-q5inrxcm 168 4 continues continue VBZ cord-352379-q5inrxcm 168 5 to to TO cord-352379-q5inrxcm 168 6 undergo undergo VB cord-352379-q5inrxcm 168 7 antigenic antigenic JJ cord-352379-q5inrxcm 168 8 changes change NNS cord-352379-q5inrxcm 168 9 in in IN cord-352379-q5inrxcm 168 10 the the DT cord-352379-q5inrxcm 168 11 field field NN cord-352379-q5inrxcm 168 12 through through IN cord-352379-q5inrxcm 168 13 both both DT cord-352379-q5inrxcm 168 14 mutation mutation NN cord-352379-q5inrxcm 168 15 and and CC cord-352379-q5inrxcm 168 16 recombination recombination NN cord-352379-q5inrxcm 168 17 involving involve VBG cord-352379-q5inrxcm 168 18 the the DT cord-352379-q5inrxcm 168 19 S S NNP cord-352379-q5inrxcm 168 20 gene gene NN cord-352379-q5inrxcm 168 21 . . . cord-352379-q5inrxcm 169 1 Recombination recombination NN cord-352379-q5inrxcm 169 2 could could MD cord-352379-q5inrxcm 169 3 occur occur VB cord-352379-q5inrxcm 169 4 between between IN cord-352379-q5inrxcm 169 5 the the DT cord-352379-q5inrxcm 169 6 field field NN cord-352379-q5inrxcm 169 7 isolates isolate NNS cord-352379-q5inrxcm 169 8 and and CC cord-352379-q5inrxcm 169 9 the the DT cord-352379-q5inrxcm 169 10 vaccine vaccine NN cord-352379-q5inrxcm 169 11 strains strain NNS cord-352379-q5inrxcm 169 12 of of IN cord-352379-q5inrxcm 169 13 IBV IBV NNP cord-352379-q5inrxcm 169 14 [ [ -LRB- cord-352379-q5inrxcm 169 15 44 44 CD cord-352379-q5inrxcm 169 16 , , , cord-352379-q5inrxcm 169 17 76 76 CD cord-352379-q5inrxcm 169 18 ] ] -RRB- cord-352379-q5inrxcm 169 19 . . . cord-352379-q5inrxcm 170 1 This this DT cord-352379-q5inrxcm 170 2 evolution evolution NN cord-352379-q5inrxcm 170 3 causes cause VBZ cord-352379-q5inrxcm 170 4 problems problem NNS cord-352379-q5inrxcm 170 5 in in IN cord-352379-q5inrxcm 170 6 vaccination vaccination NN cord-352379-q5inrxcm 170 7 strategies strategy NNS cord-352379-q5inrxcm 170 8 , , , cord-352379-q5inrxcm 170 9 as as IN cord-352379-q5inrxcm 170 10 multiple multiple JJ cord-352379-q5inrxcm 170 11 vaccines vaccine NNS cord-352379-q5inrxcm 170 12 directed direct VBN cord-352379-q5inrxcm 170 13 against against IN cord-352379-q5inrxcm 170 14 different different JJ cord-352379-q5inrxcm 170 15 viral viral JJ cord-352379-q5inrxcm 170 16 serotypes serotype NNS cord-352379-q5inrxcm 170 17 must must MD cord-352379-q5inrxcm 170 18 be be VB cord-352379-q5inrxcm 170 19 used use VBN cord-352379-q5inrxcm 170 20 simultaneously simultaneously RB cord-352379-q5inrxcm 170 21 . . . cord-352379-q5inrxcm 171 1 Another another DT cord-352379-q5inrxcm 171 2 example example NN cord-352379-q5inrxcm 171 3 is be VBZ cord-352379-q5inrxcm 171 4 the the DT cord-352379-q5inrxcm 171 5 emergence emergence NN cord-352379-q5inrxcm 171 6 of of IN cord-352379-q5inrxcm 171 7 porcine porcine JJ cord-352379-q5inrxcm 171 8 respiratory respiratory JJ cord-352379-q5inrxcm 171 9 coronavirus coronavirus NN cord-352379-q5inrxcm 171 10 ( ( -LRB- cord-352379-q5inrxcm 171 11 PRCoV prcov NN cord-352379-q5inrxcm 171 12 ) ) -RRB- cord-352379-q5inrxcm 171 13 from from IN cord-352379-q5inrxcm 171 14 the the DT cord-352379-q5inrxcm 171 15 enteric enteric JJ cord-352379-q5inrxcm 171 16 TGEV TGEV NNS cord-352379-q5inrxcm 171 17 in in IN cord-352379-q5inrxcm 171 18 Europe Europe NNP cord-352379-q5inrxcm 171 19 as as RB cord-352379-q5inrxcm 171 20 well well RB cord-352379-q5inrxcm 171 21 as as IN cord-352379-q5inrxcm 171 22 in in IN cord-352379-q5inrxcm 171 23 the the DT cord-352379-q5inrxcm 171 24 US US NNP cord-352379-q5inrxcm 171 25 in in IN cord-352379-q5inrxcm 171 26 the the DT cord-352379-q5inrxcm 171 27 1980s 1980 NNS cord-352379-q5inrxcm 171 28 [ [ -LRB- cord-352379-q5inrxcm 171 29 50 50 CD cord-352379-q5inrxcm 171 30 ] ] -RRB- cord-352379-q5inrxcm 171 31 . . . cord-352379-q5inrxcm 172 1 Again again RB cord-352379-q5inrxcm 172 2 , , , cord-352379-q5inrxcm 172 3 this this DT cord-352379-q5inrxcm 172 4 shift shift NN cord-352379-q5inrxcm 172 5 in in IN cord-352379-q5inrxcm 172 6 viral viral JJ cord-352379-q5inrxcm 172 7 tissue tissue NN cord-352379-q5inrxcm 172 8 tropism tropism NN cord-352379-q5inrxcm 172 9 and and CC cord-352379-q5inrxcm 172 10 virulence virulence NN cord-352379-q5inrxcm 172 11 was be VBD cord-352379-q5inrxcm 172 12 due due JJ cord-352379-q5inrxcm 172 13 to to IN cord-352379-q5inrxcm 172 14 deletions deletion NNS cord-352379-q5inrxcm 172 15 and and CC cord-352379-q5inrxcm 172 16 mutations mutation NNS cord-352379-q5inrxcm 172 17 in in IN cord-352379-q5inrxcm 172 18 the the DT cord-352379-q5inrxcm 172 19 S S NNP cord-352379-q5inrxcm 172 20 gene gene NN cord-352379-q5inrxcm 172 21 . . . cord-352379-q5inrxcm 173 1 This this DT cord-352379-q5inrxcm 173 2 evolution evolution NN cord-352379-q5inrxcm 173 3 turned turn VBD cord-352379-q5inrxcm 173 4 out out RP cord-352379-q5inrxcm 173 5 to to TO cord-352379-q5inrxcm 173 6 be be VB cord-352379-q5inrxcm 173 7 beneficial beneficial JJ cord-352379-q5inrxcm 173 8 to to IN cord-352379-q5inrxcm 173 9 the the DT cord-352379-q5inrxcm 173 10 livestock livestock NN cord-352379-q5inrxcm 173 11 industry industry NN cord-352379-q5inrxcm 173 12 because because IN cord-352379-q5inrxcm 173 13 the the DT cord-352379-q5inrxcm 173 14 resultant resultant JJ cord-352379-q5inrxcm 173 15 PRCoV PRCoV NNP cord-352379-q5inrxcm 173 16 is be VBZ cord-352379-q5inrxcm 173 17 considerably considerably RB cord-352379-q5inrxcm 173 18 less less RBR cord-352379-q5inrxcm 173 19 virulent virulent JJ cord-352379-q5inrxcm 173 20 than than IN cord-352379-q5inrxcm 173 21 the the DT cord-352379-q5inrxcm 173 22 parental parental JJ cord-352379-q5inrxcm 173 23 TGEV TGEV NNS cord-352379-q5inrxcm 173 24 and and CC cord-352379-q5inrxcm 173 25 , , , cord-352379-q5inrxcm 173 26 in in IN cord-352379-q5inrxcm 173 27 fact fact NN cord-352379-q5inrxcm 173 28 , , , cord-352379-q5inrxcm 173 29 was be VBD cord-352379-q5inrxcm 173 30 used use VBN cord-352379-q5inrxcm 173 31 as as IN cord-352379-q5inrxcm 173 32 an an DT cord-352379-q5inrxcm 173 33 attenuated attenuated JJ cord-352379-q5inrxcm 173 34 virus virus NN cord-352379-q5inrxcm 173 35 vaccine vaccine NN cord-352379-q5inrxcm 173 36 for for IN cord-352379-q5inrxcm 173 37 TGEV TGEV NNP cord-352379-q5inrxcm 173 38 . . . cord-352379-q5inrxcm 174 1 A a DT cord-352379-q5inrxcm 174 2 feline feline JJ cord-352379-q5inrxcm 174 3 comnavirus comnavirus NN cord-352379-q5inrxcm 174 4 has have VBZ cord-352379-q5inrxcm 174 5 also also RB cord-352379-q5inrxcm 174 6 been be VBN cord-352379-q5inrxcm 174 7 demonstrated demonstrate VBN cord-352379-q5inrxcm 174 8 to to TO cord-352379-q5inrxcm 174 9 have have VB cord-352379-q5inrxcm 174 10 undergone undergo VBN cord-352379-q5inrxcm 174 11 recombination recombination NN cord-352379-q5inrxcm 174 12 with with IN cord-352379-q5inrxcm 174 13 a a DT cord-352379-q5inrxcm 174 14 canine canine JJ cord-352379-q5inrxcm 174 15 coronavirus coronavirus NN cord-352379-q5inrxcm 174 16 , , , cord-352379-q5inrxcm 174 17 resulting result VBG cord-352379-q5inrxcm 174 18 in in IN cord-352379-q5inrxcm 174 19 changes change NNS cord-352379-q5inrxcm 174 20 in in IN cord-352379-q5inrxcm 174 21 the the DT cord-352379-q5inrxcm 174 22 biological biological JJ cord-352379-q5inrxcm 174 23 properties property NNS cord-352379-q5inrxcm 174 24 of of IN cord-352379-q5inrxcm 174 25 the the DT cord-352379-q5inrxcm 174 26 virus virus NN cord-352379-q5inrxcm 174 27 [ [ -LRB- cord-352379-q5inrxcm 174 28 35 35 CD cord-352379-q5inrxcm 174 29 ] ] -RRB- cord-352379-q5inrxcm 174 30 . . . cord-352379-q5inrxcm 175 1 The the DT cord-352379-q5inrxcm 175 2 ability ability NN cord-352379-q5inrxcm 175 3 of of IN cord-352379-q5inrxcm 175 4 the the DT cord-352379-q5inrxcm 175 5 coronavirus coronavirus NN cord-352379-q5inrxcm 175 6 to to TO cord-352379-q5inrxcm 175 7 recombine recombine VB cord-352379-q5inrxcm 175 8 has have VBZ cord-352379-q5inrxcm 175 9 been be VBN cord-352379-q5inrxcm 175 10 utilized utilize VBN cord-352379-q5inrxcm 175 11 as as IN cord-352379-q5inrxcm 175 12 a a DT cord-352379-q5inrxcm 175 13 genetic genetic JJ cord-352379-q5inrxcm 175 14 tool tool NN cord-352379-q5inrxcm 175 15 for for IN cord-352379-q5inrxcm 175 16 manipulating manipulate VBG cord-352379-q5inrxcm 175 17 the the DT cord-352379-q5inrxcm 175 18 coronavirus coronavirus NN cord-352379-q5inrxcm 175 19 genome genome NN cord-352379-q5inrxcm 175 20 . . . cord-352379-q5inrxcm 176 1 Until until IN cord-352379-q5inrxcm 176 2 recently recently RB cord-352379-q5inrxcm 176 3 it -PRON- PRP cord-352379-q5inrxcm 176 4 had have VBD cord-352379-q5inrxcm 176 5 been be VBN cord-352379-q5inrxcm 176 6 impossible impossible JJ cord-352379-q5inrxcm 176 7 to to TO cord-352379-q5inrxcm 176 8 apply apply VB cord-352379-q5inrxcm 176 9 reverse reverse JJ cord-352379-q5inrxcm 176 10 genetic genetic JJ cord-352379-q5inrxcm 176 11 methods method NNS cord-352379-q5inrxcm 176 12 for for IN cord-352379-q5inrxcm 176 13 studying study VBG cord-352379-q5inrxcm 176 14 coronaviruses coronaviruse NNS cord-352379-q5inrxcm 176 15 because because IN cord-352379-q5inrxcm 176 16 of of IN cord-352379-q5inrxcm 176 17 the the DT cord-352379-q5inrxcm 176 18 large large JJ cord-352379-q5inrxcm 176 19 size size NN cord-352379-q5inrxcm 176 20 of of IN cord-352379-q5inrxcm 176 21 its -PRON- PRP$ cord-352379-q5inrxcm 176 22 genome genome NN cord-352379-q5inrxcm 176 23 . . . cord-352379-q5inrxcm 177 1 Taking take VBG cord-352379-q5inrxcm 177 2 advantage advantage NN cord-352379-q5inrxcm 177 3 of of IN cord-352379-q5inrxcm 177 4 the the DT cord-352379-q5inrxcm 177 5 ability ability NN cord-352379-q5inrxcm 177 6 of of IN cord-352379-q5inrxcm 177 7 coronavirus coronavirus NN cord-352379-q5inrxcm 177 8 to to TO cord-352379-q5inrxcm 177 9 recombine recombine VB cord-352379-q5inrxcm 177 10 with with IN cord-352379-q5inrxcm 177 11 not not RB cord-352379-q5inrxcm 177 12 only only RB cord-352379-q5inrxcm 177 13 other other JJ cord-352379-q5inrxcm 177 14 coronaviruses coronaviruse NNS cord-352379-q5inrxcm 177 15 but but CC cord-352379-q5inrxcm 177 16 also also RB cord-352379-q5inrxcm 177 17 viral viral JJ cord-352379-q5inrxcm 177 18 RNA rna NN cord-352379-q5inrxcm 177 19 fragments fragment NNS cord-352379-q5inrxcm 177 20 , , , cord-352379-q5inrxcm 177 21 Masters Masters NNPS cord-352379-q5inrxcm 177 22 and and CC cord-352379-q5inrxcm 177 23 his -PRON- PRP$ cord-352379-q5inrxcm 177 24 colleagues colleague NNS cord-352379-q5inrxcm 177 25 have have VBP cord-352379-q5inrxcm 177 26 developed develop VBN cord-352379-q5inrxcm 177 27 techniques technique NNS cord-352379-q5inrxcm 177 28 to to TO cord-352379-q5inrxcm 177 29 introduce introduce VB cord-352379-q5inrxcm 177 30 mutations mutation NNS cord-352379-q5inrxcm 177 31 into into IN cord-352379-q5inrxcm 177 32 MHV MHV NNP cord-352379-q5inrxcm 177 33 defective defective JJ cord-352379-q5inrxcm 177 34 interfering interfere VBG cord-352379-q5inrxcm 177 35 RNA RNA NNP cord-352379-q5inrxcm 177 36 and and CC cord-352379-q5inrxcm 177 37 allow allow VB cord-352379-q5inrxcm 177 38 it -PRON- PRP cord-352379-q5inrxcm 177 39 to to TO cord-352379-q5inrxcm 177 40 recombine recombine VB cord-352379-q5inrxcm 177 41 with with IN cord-352379-q5inrxcm 177 42 a a DT cord-352379-q5inrxcm 177 43 temperature temperature NN cord-352379-q5inrxcm 177 44 - - HYPH cord-352379-q5inrxcm 177 45 sensitive sensitive JJ cord-352379-q5inrxcm 177 46 mutant mutant NN cord-352379-q5inrxcm 177 47 ( ( -LRB- cord-352379-q5inrxcm 177 48 the the DT cord-352379-q5inrxcm 177 49 mutation mutation NN cord-352379-q5inrxcm 177 50 being be VBG cord-352379-q5inrxcm 177 51 in in IN cord-352379-q5inrxcm 177 52 the the DT cord-352379-q5inrxcm 177 53 N n CD cord-352379-q5inrxcm 177 54 protein protein NN cord-352379-q5inrxcm 177 55 - - HYPH cord-352379-q5inrxcm 177 56 coding code VBG cord-352379-q5inrxcm 177 57 region region NN cord-352379-q5inrxcm 177 58 ) ) -RRB- cord-352379-q5inrxcm 177 59 of of IN cord-352379-q5inrxcm 177 60 MHV MHV NNP cord-352379-q5inrxcm 177 61 [ [ -LRB- cord-352379-q5inrxcm 177 62 63 63 CD cord-352379-q5inrxcm 177 63 ] ] -RRB- cord-352379-q5inrxcm 177 64 . . . cord-352379-q5inrxcm 178 1 By by IN cord-352379-q5inrxcm 178 2 selecting select VBG cord-352379-q5inrxcm 178 3 wild wild JJ cord-352379-q5inrxcm 178 4 - - HYPH cord-352379-q5inrxcm 178 5 type type NN cord-352379-q5inrxcm 178 6 viruses virus NNS cord-352379-q5inrxcm 178 7 capable capable JJ cord-352379-q5inrxcm 178 8 of of IN cord-352379-q5inrxcm 178 9 growing grow VBG cord-352379-q5inrxcm 178 10 at at IN cord-352379-q5inrxcm 178 11 the the DT cord-352379-q5inrxcm 178 12 high high JJ cord-352379-q5inrxcm 178 13 temperature temperature NN cord-352379-q5inrxcm 178 14 and and CC cord-352379-q5inrxcm 178 15 using use VBG cord-352379-q5inrxcm 178 16 other other JJ cord-352379-q5inrxcm 178 17 selection selection NN cord-352379-q5inrxcm 178 18 markers marker NNS cord-352379-q5inrxcm 178 19 , , , cord-352379-q5inrxcm 178 20 it -PRON- PRP cord-352379-q5inrxcm 178 21 is be VBZ cord-352379-q5inrxcm 178 22 now now RB cord-352379-q5inrxcm 178 23 possible possible JJ cord-352379-q5inrxcm 178 24 to to TO cord-352379-q5inrxcm 178 25 engineer engineer VB cord-352379-q5inrxcm 178 26 mutations mutation NNS cord-352379-q5inrxcm 178 27 into into IN cord-352379-q5inrxcm 178 28 certain certain JJ cord-352379-q5inrxcm 178 29 viral viral JJ cord-352379-q5inrxcm 178 30 RNA RNA NNP cord-352379-q5inrxcm 178 31 regions region NNS cord-352379-q5inrxcm 178 32 or or CC cord-352379-q5inrxcm 178 33 exchange exchange VB cord-352379-q5inrxcm 178 34 certain certain JJ cord-352379-q5inrxcm 178 35 viral viral JJ cord-352379-q5inrxcm 178 36 genes gene NNS cord-352379-q5inrxcm 178 37 between between IN cord-352379-q5inrxcm 178 38 different different JJ cord-352379-q5inrxcm 178 39 coronaviruses coronaviruse NNS cord-352379-q5inrxcm 178 40 [ [ -LRB- cord-352379-q5inrxcm 178 41 32 32 CD cord-352379-q5inrxcm 178 42 ] ] -RRB- cord-352379-q5inrxcm 178 43 . . . cord-352379-q5inrxcm 179 1 This this DT cord-352379-q5inrxcm 179 2 technique technique NN cord-352379-q5inrxcm 179 3 has have VBZ cord-352379-q5inrxcm 179 4 been be VBN cord-352379-q5inrxcm 179 5 applied apply VBN cord-352379-q5inrxcm 179 6 only only RB cord-352379-q5inrxcm 179 7 to to IN cord-352379-q5inrxcm 179 8 MHV MHV NNP cord-352379-q5inrxcm 179 9 so so RB cord-352379-q5inrxcm 179 10 far far RB cord-352379-q5inrxcm 179 11 . . . cord-352379-q5inrxcm 180 1 However however RB cord-352379-q5inrxcm 180 2 , , , cord-352379-q5inrxcm 180 3 a a DT cord-352379-q5inrxcm 180 4 flood flood NN cord-352379-q5inrxcm 180 5 of of IN cord-352379-q5inrxcm 180 6 reports report NNS cord-352379-q5inrxcm 180 7 in in IN cord-352379-q5inrxcm 180 8 the the DT cord-352379-q5inrxcm 180 9 last last JJ cord-352379-q5inrxcm 180 10 2 2 CD cord-352379-q5inrxcm 180 11 years year NNS cord-352379-q5inrxcm 180 12 has have VBZ cord-352379-q5inrxcm 180 13 shown show VBN cord-352379-q5inrxcm 180 14 that that IN cord-352379-q5inrxcm 180 15 full full JJ cord-352379-q5inrxcm 180 16 - - HYPH cord-352379-q5inrxcm 180 17 length length NN cord-352379-q5inrxcm 180 18 infectious infectious JJ cord-352379-q5inrxcm 180 19 cDNA cdna NN cord-352379-q5inrxcm 180 20 clones clone NNS cord-352379-q5inrxcm 180 21 can can MD cord-352379-q5inrxcm 180 22 be be VB cord-352379-q5inrxcm 180 23 obtained obtain VBN cord-352379-q5inrxcm 180 24 for for IN cord-352379-q5inrxcm 180 25 several several JJ cord-352379-q5inrxcm 180 26 coronaviruses coronaviruse NNS cord-352379-q5inrxcm 180 27 , , , cord-352379-q5inrxcm 180 28 including include VBG cord-352379-q5inrxcm 180 29 TGEV TGEV NNP cord-352379-q5inrxcm 180 30 , , , cord-352379-q5inrxcm 180 31 MHV MHV NNP cord-352379-q5inrxcm 180 32 , , , cord-352379-q5inrxcm 180 33 HCoV-229E HCoV-229E NNP cord-352379-q5inrxcm 180 34 , , , cord-352379-q5inrxcm 180 35 PEDV PEDV NNP cord-352379-q5inrxcm 180 36 and and CC cord-352379-q5inrxcm 180 37 IBV IBV NNP cord-352379-q5inrxcm 180 38 [ [ -LRB- cord-352379-q5inrxcm 180 39 2 2 CD cord-352379-q5inrxcm 180 40 , , , cord-352379-q5inrxcm 180 41 14 14 CD cord-352379-q5inrxcm 180 42 , , , cord-352379-q5inrxcm 180 43 72 72 CD cord-352379-q5inrxcm 180 44 , , , cord-352379-q5inrxcm 180 45 81 81 CD cord-352379-q5inrxcm 180 46 ] ] -RRB- cord-352379-q5inrxcm 180 47 . . . cord-352379-q5inrxcm 181 1 These these DT cord-352379-q5inrxcm 181 2 cDNA cdna NN cord-352379-q5inrxcm 181 3 clones clone NNS cord-352379-q5inrxcm 181 4 have have VBP cord-352379-q5inrxcm 181 5 added add VBN cord-352379-q5inrxcm 181 6 to to IN cord-352379-q5inrxcm 181 7 the the DT cord-352379-q5inrxcm 181 8 arsenal arsenal NN cord-352379-q5inrxcm 181 9 of of IN cord-352379-q5inrxcm 181 10 coronavirus coronavirus NN cord-352379-q5inrxcm 181 11 genetic genetic JJ cord-352379-q5inrxcm 181 12 tools tool NNS cord-352379-q5inrxcm 181 13 . . . cord-352379-q5inrxcm 182 1 It -PRON- PRP cord-352379-q5inrxcm 182 2 is be VBZ cord-352379-q5inrxcm 182 3 anticipated anticipate VBN cord-352379-q5inrxcm 182 4 that that IN cord-352379-q5inrxcm 182 5 the the DT cord-352379-q5inrxcm 182 6 full full JJ cord-352379-q5inrxcm 182 7 - - HYPH cord-352379-q5inrxcm 182 8 length length NN cord-352379-q5inrxcm 182 9 SARS SARS NNP cord-352379-q5inrxcm 182 10 virus virus NN cord-352379-q5inrxcm 182 11 cDNA cDNA NNP cord-352379-q5inrxcm 182 12 will will MD cord-352379-q5inrxcm 182 13 be be VB cord-352379-q5inrxcm 182 14 available available JJ cord-352379-q5inrxcm 182 15 soon soon RB cord-352379-q5inrxcm 182 16 . . . cord-352379-q5inrxcm 183 1 Both both CC cord-352379-q5inrxcm 183 2 this this DT cord-352379-q5inrxcm 183 3 cDNA cdna NN cord-352379-q5inrxcm 183 4 and and CC cord-352379-q5inrxcm 183 5 the the DT cord-352379-q5inrxcm 183 6 targeted target VBN cord-352379-q5inrxcm 183 7 recombination recombination NN cord-352379-q5inrxcm 183 8 approach approach NN cord-352379-q5inrxcm 183 9 may may MD cord-352379-q5inrxcm 183 10 provide provide VB cord-352379-q5inrxcm 183 11 the the DT cord-352379-q5inrxcm 183 12 reverse reverse JJ cord-352379-q5inrxcm 183 13 genetic genetic JJ cord-352379-q5inrxcm 183 14 tools tool NNS cord-352379-q5inrxcm 183 15 for for IN cord-352379-q5inrxcm 183 16 studying study VBG cord-352379-q5inrxcm 183 17 SARS SARS NNP cord-352379-q5inrxcm 183 18 virus virus NN cord-352379-q5inrxcm 183 19 . . . cord-352379-q5inrxcm 184 1 The the DT cord-352379-q5inrxcm 184 2 temptation temptation NN cord-352379-q5inrxcm 184 3 to to TO cord-352379-q5inrxcm 184 4 manipulate manipulate VB cord-352379-q5inrxcm 184 5 the the DT cord-352379-q5inrxcm 184 6 SARS SARS NNP cord-352379-q5inrxcm 184 7 virus virus NN cord-352379-q5inrxcm 184 8 genome genome NN cord-352379-q5inrxcm 184 9 will will MD cord-352379-q5inrxcm 184 10 be be VB cord-352379-q5inrxcm 184 11 great great JJ cord-352379-q5inrxcm 184 12 . . . cord-352379-q5inrxcm 185 1 However however RB cord-352379-q5inrxcm 185 2 , , , cord-352379-q5inrxcm 185 3 I -PRON- PRP cord-352379-q5inrxcm 185 4 must must MD cord-352379-q5inrxcm 185 5 add add VB cord-352379-q5inrxcm 185 6 a a DT cord-352379-q5inrxcm 185 7 word word NN cord-352379-q5inrxcm 185 8 of of IN cord-352379-q5inrxcm 185 9 caution caution NN cord-352379-q5inrxcm 185 10 before before IN cord-352379-q5inrxcm 185 11 such such JJ cord-352379-q5inrxcm 185 12 attempts attempt NNS cord-352379-q5inrxcm 185 13 are be VBP cord-352379-q5inrxcm 185 14 made make VBN cord-352379-q5inrxcm 185 15 . . . cord-352379-q5inrxcm 186 1 The the DT cord-352379-q5inrxcm 186 2 scientific scientific JJ cord-352379-q5inrxcm 186 3 community community NN cord-352379-q5inrxcm 186 4 must must MD cord-352379-q5inrxcm 186 5 be be VB cord-352379-q5inrxcm 186 6 vigilant vigilant JJ cord-352379-q5inrxcm 186 7 in in IN cord-352379-q5inrxcm 186 8 guarding guard VBG cord-352379-q5inrxcm 186 9 against against IN cord-352379-q5inrxcm 186 10 the the DT cord-352379-q5inrxcm 186 11 misuse misuse NN cord-352379-q5inrxcm 186 12 of of IN cord-352379-q5inrxcm 186 13 these these DT cord-352379-q5inrxcm 186 14 genetic genetic JJ cord-352379-q5inrxcm 186 15 tools tool NNS cord-352379-q5inrxcm 186 16 to to TO cord-352379-q5inrxcm 186 17 alter alter VB cord-352379-q5inrxcm 186 18 the the DT cord-352379-q5inrxcm 186 19 SARS SARS NNP cord-352379-q5inrxcm 186 20 virus virus NN cord-352379-q5inrxcm 186 21 genome genome NN cord-352379-q5inrxcm 186 22 or or CC cord-352379-q5inrxcm 186 23 create create VB cord-352379-q5inrxcm 186 24 chimeric chimeric JJ cord-352379-q5inrxcm 186 25 coronaviruses coronaviruse NNS cord-352379-q5inrxcm 186 26 involving involve VBG cord-352379-q5inrxcm 186 27 SARS SARS NNP cord-352379-q5inrxcm 186 28 virus virus NN cord-352379-q5inrxcm 186 29 genes gene NNS cord-352379-q5inrxcm 186 30 . . . cord-352379-q5inrxcm 187 1 I -PRON- PRP cord-352379-q5inrxcm 187 2 propose propose VBP cord-352379-q5inrxcm 187 3 a a DT cord-352379-q5inrxcm 187 4 moratorium moratorium NN cord-352379-q5inrxcm 187 5 on on IN cord-352379-q5inrxcm 187 6 these these DT cord-352379-q5inrxcm 187 7 types type NNS cord-352379-q5inrxcm 187 8 of of IN cord-352379-q5inrxcm 187 9 experiments experiment NNS cord-352379-q5inrxcm 187 10 until until IN cord-352379-q5inrxcm 187 11 the the DT cord-352379-q5inrxcm 187 12 various various JJ cord-352379-q5inrxcm 187 13 concerned concerned JJ cord-352379-q5inrxcm 187 14 international international JJ cord-352379-q5inrxcm 187 15 communities community NNS cord-352379-q5inrxcm 187 16 agree agree VBP cord-352379-q5inrxcm 187 17 upon upon IN cord-352379-q5inrxcm 187 18 specific specific JJ cord-352379-q5inrxcm 187 19 guidelines guideline NNS cord-352379-q5inrxcm 187 20 . . . cord-352379-q5inrxcm 188 1 The the DT cord-352379-q5inrxcm 188 2 potential potential NN cord-352379-q5inrxcm 188 3 for for IN cord-352379-q5inrxcm 188 4 unleashing unleash VBG cord-352379-q5inrxcm 188 5 a a DT cord-352379-q5inrxcm 188 6 more more RBR cord-352379-q5inrxcm 188 7 virulent virulent JJ cord-352379-q5inrxcm 188 8 new new JJ cord-352379-q5inrxcm 188 9 SARS SARS NNP cord-352379-q5inrxcm 188 10 virus virus NN cord-352379-q5inrxcm 188 11 is be VBZ cord-352379-q5inrxcm 188 12 simply simply RB cord-352379-q5inrxcm 188 13 too too RB cord-352379-q5inrxcm 188 14 onerous onerous JJ cord-352379-q5inrxcm 188 15 to to TO cord-352379-q5inrxcm 188 16 be be VB cord-352379-q5inrxcm 188 17 ignored ignore VBN cord-352379-q5inrxcm 188 18 . . . cord-352379-q5inrxcm 189 1 Coronaviruses Coronaviruses NNP cord-352379-q5inrxcm 189 2 , , , cord-352379-q5inrxcm 189 3 in in IN cord-352379-q5inrxcm 189 4 general general JJ cord-352379-q5inrxcm 189 5 , , , cord-352379-q5inrxcm 189 6 cause cause VB cord-352379-q5inrxcm 189 7 disease disease NN cord-352379-q5inrxcm 189 8 by by IN cord-352379-q5inrxcm 189 9 both both DT cord-352379-q5inrxcm 189 10 cytocidal cytocidal NN cord-352379-q5inrxcm 189 11 and and CC cord-352379-q5inrxcm 189 12 immune immune NN cord-352379-q5inrxcm 189 13 - - HYPH cord-352379-q5inrxcm 189 14 mediated mediate VBN cord-352379-q5inrxcm 189 15 mechanisms mechanism NNS cord-352379-q5inrxcm 189 16 . . . cord-352379-q5inrxcm 190 1 Most Most JJS cord-352379-q5inrxcm 190 2 coronavirus coronavirus NN cord-352379-q5inrxcm 190 3 infections infection NNS cord-352379-q5inrxcm 190 4 in in IN cord-352379-q5inrxcm 190 5 cell cell NN cord-352379-q5inrxcm 190 6 culture culture NN cord-352379-q5inrxcm 190 7 result result NN cord-352379-q5inrxcm 190 8 in in IN cord-352379-q5inrxcm 190 9 lysis lysis NN cord-352379-q5inrxcm 190 10 or or CC cord-352379-q5inrxcm 190 11 apoptosis apoptosis NN cord-352379-q5inrxcm 190 12 of of IN cord-352379-q5inrxcm 190 13 the the DT cord-352379-q5inrxcm 190 14 infected infected JJ cord-352379-q5inrxcm 190 15 cells cell NNS cord-352379-q5inrxcm 190 16 [ [ -LRB- cord-352379-q5inrxcm 190 17 53 53 CD cord-352379-q5inrxcm 190 18 ] ] -RRB- cord-352379-q5inrxcm 190 19 . . . cord-352379-q5inrxcm 191 1 Furthermore furthermore RB cord-352379-q5inrxcm 191 2 , , , cord-352379-q5inrxcm 191 3 the the DT cord-352379-q5inrxcm 191 4 virus virus NN cord-352379-q5inrxcm 191 5 causes cause VBZ cord-352379-q5inrxcm 191 6 cell cell NN cord-352379-q5inrxcm 191 7 fusion fusion NN cord-352379-q5inrxcm 191 8 , , , cord-352379-q5inrxcm 191 9 resulting result VBG cord-352379-q5inrxcm 191 10 in in IN cord-352379-q5inrxcm 191 11 the the DT cord-352379-q5inrxcm 191 12 formation formation NN cord-352379-q5inrxcm 191 13 of of IN cord-352379-q5inrxcm 191 14 cell cell NN cord-352379-q5inrxcm 191 15 syncytia syncytia NN cord-352379-q5inrxcm 191 16 . . . cord-352379-q5inrxcm 192 1 These these DT cord-352379-q5inrxcm 192 2 cytopathic cytopathic JJ cord-352379-q5inrxcm 192 3 effects effect NNS cord-352379-q5inrxcm 192 4 ( ( -LRB- cord-352379-q5inrxcm 192 5 CPE CPE NNP cord-352379-q5inrxcm 192 6 ) ) -RRB- cord-352379-q5inrxcm 192 7 are be VBP cord-352379-q5inrxcm 192 8 usually usually RB cord-352379-q5inrxcm 192 9 the the DT cord-352379-q5inrxcm 192 10 results result NNS cord-352379-q5inrxcm 192 11 of of IN cord-352379-q5inrxcm 192 12 viral viral JJ cord-352379-q5inrxcm 192 13 replication replication NN cord-352379-q5inrxcm 192 14 . . . cord-352379-q5inrxcm 193 1 For for IN cord-352379-q5inrxcm 193 2 example example NN cord-352379-q5inrxcm 193 3 , , , cord-352379-q5inrxcm 193 4 the the DT cord-352379-q5inrxcm 193 5 coronavirus coronavirus NN cord-352379-q5inrxcm 193 6 mobilizes mobilize VBZ cord-352379-q5inrxcm 193 7 cellular cellular JJ cord-352379-q5inrxcm 193 8 vesicles vesicle NNS cord-352379-q5inrxcm 193 9 to to TO cord-352379-q5inrxcm 193 10 form form VB cord-352379-q5inrxcm 193 11 the the DT cord-352379-q5inrxcm 193 12 viral viral JJ cord-352379-q5inrxcm 193 13 replication replication NN cord-352379-q5inrxcm 193 14 complex complex NN cord-352379-q5inrxcm 193 15 [ [ -LRB- cord-352379-q5inrxcm 193 16 30 30 CD cord-352379-q5inrxcm 193 17 ] ] -RRB- cord-352379-q5inrxcm 193 18 , , , cord-352379-q5inrxcm 193 19 which which WDT cord-352379-q5inrxcm 193 20 may may MD cord-352379-q5inrxcm 193 21 disrupt disrupt VB cord-352379-q5inrxcm 193 22 the the DT cord-352379-q5inrxcm 193 23 Golgi Golgi NNP cord-352379-q5inrxcm 193 24 complex complex NN cord-352379-q5inrxcm 193 25 [ [ -LRB- cord-352379-q5inrxcm 193 26 51 51 CD cord-352379-q5inrxcm 193 27 ] ] -RRB- cord-352379-q5inrxcm 193 28 . . . cord-352379-q5inrxcm 194 1 SARS SARS NNP cord-352379-q5inrxcm 194 2 virus virus NN cord-352379-q5inrxcm 194 3 also also RB cord-352379-q5inrxcm 194 4 causes cause VBZ cord-352379-q5inrxcm 194 5 CPE CPE NNP cord-352379-q5inrxcm 194 6 in in IN cord-352379-q5inrxcm 194 7 Vero Vero NNP cord-352379-q5inrxcm 194 8 cells cell NNS cord-352379-q5inrxcm 194 9 ; ; : cord-352379-q5inrxcm 194 10 furthermore furthermore RB cord-352379-q5inrxcm 194 11 , , , cord-352379-q5inrxcm 194 12 it -PRON- PRP cord-352379-q5inrxcm 194 13 causes cause VBZ cord-352379-q5inrxcm 194 14 syncytia syncytia NN cord-352379-q5inrxcm 194 15 formation formation NN cord-352379-q5inrxcm 194 16 in in IN cord-352379-q5inrxcm 194 17 the the DT cord-352379-q5inrxcm 194 18 lung lung NN cord-352379-q5inrxcm 194 19 tissue tissue NN cord-352379-q5inrxcm 194 20 , , , cord-352379-q5inrxcm 194 21 suggesting suggest VBG cord-352379-q5inrxcm 194 22 that that IN cord-352379-q5inrxcm 194 23 it -PRON- PRP cord-352379-q5inrxcm 194 24 causes cause VBZ cord-352379-q5inrxcm 194 25 cytocidal cytocidal JJ cord-352379-q5inrxcm 194 26 effects effect NNS cord-352379-q5inrxcm 194 27 . . . cord-352379-q5inrxcm 195 1 Another another DT cord-352379-q5inrxcm 195 2 eerie eerie JJ cord-352379-q5inrxcm 195 3 similarity similarity NN cord-352379-q5inrxcm 195 4 between between IN cord-352379-q5inrxcm 195 5 SARS SARS NNP cord-352379-q5inrxcm 195 6 virus virus NN cord-352379-q5inrxcm 195 7 and and CC cord-352379-q5inrxcm 195 8 other other JJ cord-352379-q5inrxcm 195 9 coronaviruses coronaviruse NNS cord-352379-q5inrxcm 195 10 is be VBZ cord-352379-q5inrxcm 195 11 their -PRON- PRP$ cord-352379-q5inrxcm 195 12 ability ability NN cord-352379-q5inrxcm 195 13 to to TO cord-352379-q5inrxcm 195 14 induce induce VB cord-352379-q5inrxcm 195 15 fibrosis fibrosis NN cord-352379-q5inrxcm 195 16 ; ; : cord-352379-q5inrxcm 195 17 e.g. e.g. IN cord-352379-q5inrxcm 195 18 certain certain JJ cord-352379-q5inrxcm 195 19 strains strain NNS cord-352379-q5inrxcm 195 20 of of IN cord-352379-q5inrxcm 195 21 MHV MHV NNP cord-352379-q5inrxcm 195 22 cause cause VBP cord-352379-q5inrxcm 195 23 fibrosis fibrosis NN cord-352379-q5inrxcm 195 24 in in IN cord-352379-q5inrxcm 195 25 the the DT cord-352379-q5inrxcm 195 26 liver liver NN cord-352379-q5inrxcm 195 27 [ [ -LRB- cord-352379-q5inrxcm 195 28 22 22 CD cord-352379-q5inrxcm 195 29 ] ] -RRB- cord-352379-q5inrxcm 195 30 , , , cord-352379-q5inrxcm 195 31 and and CC cord-352379-q5inrxcm 195 32 SARS SARS NNP cord-352379-q5inrxcm 195 33 virus virus NN cord-352379-q5inrxcm 195 34 causes cause VBZ cord-352379-q5inrxcm 195 35 fibrosis fibrosis NN cord-352379-q5inrxcm 195 36 in in IN cord-352379-q5inrxcm 195 37 the the DT cord-352379-q5inrxcm 195 38 lung lung NN cord-352379-q5inrxcm 195 39 [ [ -LRB- cord-352379-q5inrxcm 195 40 58 58 CD cord-352379-q5inrxcm 195 41 ] ] -RRB- cord-352379-q5inrxcm 195 42 . . . cord-352379-q5inrxcm 196 1 The the DT cord-352379-q5inrxcm 196 2 N n CD cord-352379-q5inrxcm 196 3 protein protein NN cord-352379-q5inrxcm 196 4 of of IN cord-352379-q5inrxcm 196 5 MHV MHV NNP cord-352379-q5inrxcm 196 6 has have VBZ cord-352379-q5inrxcm 196 7 been be VBN cord-352379-q5inrxcm 196 8 shown show VBN cord-352379-q5inrxcm 196 9 to to TO cord-352379-q5inrxcm 196 10 stimulate stimulate VB cord-352379-q5inrxcm 196 11 the the DT cord-352379-q5inrxcm 196 12 promoter promoter NN cord-352379-q5inrxcm 196 13 activity activity NN cord-352379-q5inrxcm 196 14 of of IN cord-352379-q5inrxcm 196 15 the the DT cord-352379-q5inrxcm 196 16 prothrombinase prothrombinase NNP cord-352379-q5inrxcm 196 17 gene gene NN cord-352379-q5inrxcm 196 18 [ [ -LRB- cord-352379-q5inrxcm 196 19 59 59 CD cord-352379-q5inrxcm 196 20 ] ] -RRB- cord-352379-q5inrxcm 196 21 , , , cord-352379-q5inrxcm 196 22 which which WDT cord-352379-q5inrxcm 196 23 correlates correlate VBZ cord-352379-q5inrxcm 196 24 with with IN cord-352379-q5inrxcm 196 25 the the DT cord-352379-q5inrxcm 196 26 fibrin fibrin NN cord-352379-q5inrxcm 196 27 deposit deposit NN cord-352379-q5inrxcm 196 28 in in IN cord-352379-q5inrxcm 196 29 the the DT cord-352379-q5inrxcm 196 30 liver liver NN cord-352379-q5inrxcm 196 31 associated associate VBN cord-352379-q5inrxcm 196 32 with with IN cord-352379-q5inrxcm 196 33 MHV MHV NNP cord-352379-q5inrxcm 196 34 infection infection NN cord-352379-q5inrxcm 196 35 . . . cord-352379-q5inrxcm 197 1 A a DT cord-352379-q5inrxcm 197 2 similar similar JJ cord-352379-q5inrxcm 197 3 mechanism mechanism NN cord-352379-q5inrxcm 197 4 may may MD cord-352379-q5inrxcm 197 5 be be VB cord-352379-q5inrxcm 197 6 involved involve VBN cord-352379-q5inrxcm 197 7 in in IN cord-352379-q5inrxcm 197 8 the the DT cord-352379-q5inrxcm 197 9 fibrosis fibrosis NN cord-352379-q5inrxcm 197 10 of of IN cord-352379-q5inrxcm 197 11 the the DT cord-352379-q5inrxcm 197 12 lung lung NN cord-352379-q5inrxcm 197 13 induced induce VBN cord-352379-q5inrxcm 197 14 by by IN cord-352379-q5inrxcm 197 15 SARS SARS NNP cord-352379-q5inrxcm 197 16 virus virus NN cord-352379-q5inrxcm 197 17 . . . cord-352379-q5inrxcm 198 1 Immune immune JJ cord-352379-q5inrxcm 198 2 responses response NNS cord-352379-q5inrxcm 198 3 also also RB cord-352379-q5inrxcm 198 4 contribute contribute VBP cord-352379-q5inrxcm 198 5 to to IN cord-352379-q5inrxcm 198 6 the the DT cord-352379-q5inrxcm 198 7 pathogenesis pathogenesis NN cord-352379-q5inrxcm 198 8 of of IN cord-352379-q5inrxcm 198 9 several several JJ cord-352379-q5inrxcm 198 10 coronaviruses coronaviruse NNS cord-352379-q5inrxcm 198 11 . . . cord-352379-q5inrxcm 199 1 Most most RBS cord-352379-q5inrxcm 199 2 notably notably RB cord-352379-q5inrxcm 199 3 , , , cord-352379-q5inrxcm 199 4 cytotoxic cytotoxic JJ cord-352379-q5inrxcm 199 5 T t NN cord-352379-q5inrxcm 199 6 cells cell NNS cord-352379-q5inrxcm 199 7 and and CC cord-352379-q5inrxcm 199 8 cytokines cytokine NNS cord-352379-q5inrxcm 199 9 play play VBP cord-352379-q5inrxcm 199 10 a a DT cord-352379-q5inrxcm 199 11 very very RB cord-352379-q5inrxcm 199 12 significant significant JJ cord-352379-q5inrxcm 199 13 role role NN cord-352379-q5inrxcm 199 14 in in IN cord-352379-q5inrxcm 199 15 the the DT cord-352379-q5inrxcm 199 16 neuropathology neuropathology NN cord-352379-q5inrxcm 199 17 caused cause VBN cord-352379-q5inrxcm 199 18 by by IN cord-352379-q5inrxcm 199 19 MHV MHV NNP cord-352379-q5inrxcm 199 20 [ [ -LRB- cord-352379-q5inrxcm 199 21 56 56 CD cord-352379-q5inrxcm 199 22 ] ] -RRB- cord-352379-q5inrxcm 199 23 . . . cord-352379-q5inrxcm 200 1 On on IN cord-352379-q5inrxcm 200 2 the the DT cord-352379-q5inrxcm 200 3 other other JJ cord-352379-q5inrxcm 200 4 hand hand NN cord-352379-q5inrxcm 200 5 , , , cord-352379-q5inrxcm 200 6 humoral humoral JJ cord-352379-q5inrxcm 200 7 antibodies antibody NNS cord-352379-q5inrxcm 200 8 are be VBP cord-352379-q5inrxcm 200 9 important important JJ cord-352379-q5inrxcm 200 10 for for IN cord-352379-q5inrxcm 200 11 the the DT cord-352379-q5inrxcm 200 12 disease disease NN cord-352379-q5inrxcm 200 13 associated associate VBN cord-352379-q5inrxcm 200 14 with with IN cord-352379-q5inrxcm 200 15 FIPV FIPV NNP cord-352379-q5inrxcm 200 16 , , , cord-352379-q5inrxcm 200 17 in in IN cord-352379-q5inrxcm 200 18 which which WDT cord-352379-q5inrxcm 200 19 certain certain JJ cord-352379-q5inrxcm 200 20 antibodies antibody NNS cord-352379-q5inrxcm 200 21 against against IN cord-352379-q5inrxcm 200 22 the the DT cord-352379-q5inrxcm 200 23 viral viral JJ cord-352379-q5inrxcm 200 24 S S NNP cord-352379-q5inrxcm 200 25 protein protein NN cord-352379-q5inrxcm 200 26 induce induce VB cord-352379-q5inrxcm 200 27 severe severe JJ cord-352379-q5inrxcm 200 28 peritonitis peritonitis NN cord-352379-q5inrxcm 200 29 symptoms symptom NNS cord-352379-q5inrxcm 200 30 [ [ -LRB- cord-352379-q5inrxcm 200 31 17 17 CD cord-352379-q5inrxcm 200 32 , , , cord-352379-q5inrxcm 200 33 78 78 CD cord-352379-q5inrxcm 200 34 ] ] -RRB- cord-352379-q5inrxcm 200 35 . . . cord-352379-q5inrxcm 201 1 In in IN cord-352379-q5inrxcm 201 2 the the DT cord-352379-q5inrxcm 201 3 case case NN cord-352379-q5inrxcm 201 4 of of IN cord-352379-q5inrxcm 201 5 SARS SARS NNP cord-352379-q5inrxcm 201 6 , , , cord-352379-q5inrxcm 201 7 there there EX cord-352379-q5inrxcm 201 8 is be VBZ cord-352379-q5inrxcm 201 9 an an DT cord-352379-q5inrxcm 201 10 occurrence occurrence NN cord-352379-q5inrxcm 201 11 of of IN cord-352379-q5inrxcm 201 12 cytokine cytokine JJ cord-352379-q5inrxcm 201 13 storms storm NNS cord-352379-q5inrxcm 201 14 and and CC cord-352379-q5inrxcm 201 15 accumulation accumulation NN cord-352379-q5inrxcm 201 16 of of IN cord-352379-q5inrxcm 201 17 inflammatory inflammatory JJ cord-352379-q5inrxcm 201 18 cells cell NNS cord-352379-q5inrxcm 201 19 , , , cord-352379-q5inrxcm 201 20 particularly particularly RB cord-352379-q5inrxcm 201 21 macrophages macrophage NNS cord-352379-q5inrxcm 201 22 in in IN cord-352379-q5inrxcm 201 23 the the DT cord-352379-q5inrxcm 201 24 lung lung NN cord-352379-q5inrxcm 201 25 , , , cord-352379-q5inrxcm 201 26 during during IN cord-352379-q5inrxcm 201 27 the the DT cord-352379-q5inrxcm 201 28 peak peak NN cord-352379-q5inrxcm 201 29 of of IN cord-352379-q5inrxcm 201 30 the the DT cord-352379-q5inrxcm 201 31 disease disease NN cord-352379-q5inrxcm 201 32 [ [ -LRB- cord-352379-q5inrxcm 201 33 58 58 CD cord-352379-q5inrxcm 201 34 ] ] -RRB- cord-352379-q5inrxcm 201 35 , , , cord-352379-q5inrxcm 201 36 suggesting suggest VBG cord-352379-q5inrxcm 201 37 that that IN cord-352379-q5inrxcm 201 38 both both DT cord-352379-q5inrxcm 201 39 innate innate JJ cord-352379-q5inrxcm 201 40 and and CC cord-352379-q5inrxcm 201 41 adaptive adaptive JJ cord-352379-q5inrxcm 201 42 immune immune JJ cord-352379-q5inrxcm 201 43 responses response NNS cord-352379-q5inrxcm 201 44 are be VBP cord-352379-q5inrxcm 201 45 important important JJ cord-352379-q5inrxcm 201 46 for for IN cord-352379-q5inrxcm 201 47 the the DT cord-352379-q5inrxcm 201 48 disease disease NN cord-352379-q5inrxcm 201 49 . . . cord-352379-q5inrxcm 202 1 Thus thus RB cord-352379-q5inrxcm 202 2 , , , cord-352379-q5inrxcm 202 3 the the DT cord-352379-q5inrxcm 202 4 clinical clinical JJ cord-352379-q5inrxcm 202 5 management management NN cord-352379-q5inrxcm 202 6 of of IN cord-352379-q5inrxcm 202 7 SARS SARS NNP cord-352379-q5inrxcm 202 8 should should MD cord-352379-q5inrxcm 202 9 consider consider VB cord-352379-q5inrxcm 202 10 not not RB cord-352379-q5inrxcm 202 11 only only RB cord-352379-q5inrxcm 202 12 antiviral antiviral JJ cord-352379-q5inrxcm 202 13 but but CC cord-352379-q5inrxcm 202 14 anti anti JJ cord-352379-q5inrxcm 202 15 - - JJ cord-352379-q5inrxcm 202 16 inflammatory inflammatory JJ cord-352379-q5inrxcm 202 17 strategies strategy NNS cord-352379-q5inrxcm 202 18 as as RB cord-352379-q5inrxcm 202 19 well well RB cord-352379-q5inrxcm 202 20 . . . cord-352379-q5inrxcm 203 1 Several several JJ cord-352379-q5inrxcm 203 2 viral viral JJ cord-352379-q5inrxcm 203 3 genes gene NNS cord-352379-q5inrxcm 203 4 are be VBP cord-352379-q5inrxcm 203 5 likely likely RB cord-352379-q5inrxcm 203 6 involved involve VBN cord-352379-q5inrxcm 203 7 in in IN cord-352379-q5inrxcm 203 8 viral viral JJ cord-352379-q5inrxcm 203 9 pathogenesis pathogenesis NN cord-352379-q5inrxcm 203 10 . . . cord-352379-q5inrxcm 204 1 Most most RBS cord-352379-q5inrxcm 204 2 importantly importantly RB cord-352379-q5inrxcm 204 3 , , , cord-352379-q5inrxcm 204 4 the the DT cord-352379-q5inrxcm 204 5 spike spike NN cord-352379-q5inrxcm 204 6 protein protein NN cord-352379-q5inrxcm 204 7 gene gene NN cord-352379-q5inrxcm 204 8 affects affect VBZ cord-352379-q5inrxcm 204 9 viral viral JJ cord-352379-q5inrxcm 204 10 pathogenesis pathogenesis NN cord-352379-q5inrxcm 204 11 not not RB cord-352379-q5inrxcm 204 12 only only RB cord-352379-q5inrxcm 204 13 by by IN cord-352379-q5inrxcm 204 14 determining determine VBG cord-352379-q5inrxcm 204 15 the the DT cord-352379-q5inrxcm 204 16 host host NN cord-352379-q5inrxcm 204 17 target target NN cord-352379-q5inrxcm 204 18 cell cell NN cord-352379-q5inrxcm 204 19 specificity specificity NN cord-352379-q5inrxcm 204 20 but but CC cord-352379-q5inrxcm 204 21 by by IN cord-352379-q5inrxcm 204 22 other other JJ cord-352379-q5inrxcm 204 23 mechanisms mechanism NNS cord-352379-q5inrxcm 204 24 as as RB cord-352379-q5inrxcm 204 25 well well RB cord-352379-q5inrxcm 204 26 . . . cord-352379-q5inrxcm 205 1 As as IN cord-352379-q5inrxcm 205 2 exemplified exemplify VBN cord-352379-q5inrxcm 205 3 above above RB cord-352379-q5inrxcm 205 4 , , , cord-352379-q5inrxcm 205 5 the the DT cord-352379-q5inrxcm 205 6 emergence emergence NN cord-352379-q5inrxcm 205 7 of of IN cord-352379-q5inrxcm 205 8 the the DT cord-352379-q5inrxcm 205 9 weakly weakly RB cord-352379-q5inrxcm 205 10 virulent virulent JJ cord-352379-q5inrxcm 205 11 PRCV PRCV NNP cord-352379-q5inrxcm 205 12 from from IN cord-352379-q5inrxcm 205 13 the the DT cord-352379-q5inrxcm 205 14 virulent virulent JJ cord-352379-q5inrxcm 205 15 enteric enteric JJ cord-352379-q5inrxcm 205 16 TGEV TGEV NNS cord-352379-q5inrxcm 205 17 was be VBD cord-352379-q5inrxcm 205 18 the the DT cord-352379-q5inrxcm 205 19 result result NN cord-352379-q5inrxcm 205 20 of of IN cord-352379-q5inrxcm 205 21 mutations mutation NNS cord-352379-q5inrxcm 205 22 in in IN cord-352379-q5inrxcm 205 23 the the DT cord-352379-q5inrxcm 205 24 S S NNP cord-352379-q5inrxcm 205 25 gene gene NN cord-352379-q5inrxcm 205 26 [ [ -LRB- cord-352379-q5inrxcm 205 27 7 7 CD cord-352379-q5inrxcm 205 28 ] ] -RRB- cord-352379-q5inrxcm 205 29 . . . cord-352379-q5inrxcm 206 1 Also also RB cord-352379-q5inrxcm 206 2 , , , cord-352379-q5inrxcm 206 3 it -PRON- PRP cord-352379-q5inrxcm 206 4 has have VBZ cord-352379-q5inrxcm 206 5 been be VBN cord-352379-q5inrxcm 206 6 shown show VBN cord-352379-q5inrxcm 206 7 that that IN cord-352379-q5inrxcm 206 8 a a DT cord-352379-q5inrxcm 206 9 single single JJ cord-352379-q5inrxcm 206 10 mutation mutation NN cord-352379-q5inrxcm 206 11 in in IN cord-352379-q5inrxcm 206 12 the the DT cord-352379-q5inrxcm 206 13 S S NNP cord-352379-q5inrxcm 206 14 gene gene NN cord-352379-q5inrxcm 206 15 of of IN cord-352379-q5inrxcm 206 16 MHV MHV NNP cord-352379-q5inrxcm 206 17 can can MD cord-352379-q5inrxcm 206 18 significantly significantly RB cord-352379-q5inrxcm 206 19 alter alter VB cord-352379-q5inrxcm 206 20 the the DT cord-352379-q5inrxcm 206 21 tissue tissue NN cord-352379-q5inrxcm 206 22 tropism tropism NN cord-352379-q5inrxcm 206 23 and and CC cord-352379-q5inrxcm 206 24 virulence virulence NN cord-352379-q5inrxcm 206 25 of of IN cord-352379-q5inrxcm 206 26 the the DT cord-352379-q5inrxcm 206 27 virus virus NN cord-352379-q5inrxcm 206 28 [ [ -LRB- cord-352379-q5inrxcm 206 29 52 52 CD cord-352379-q5inrxcm 206 30 ] ] -RRB- cord-352379-q5inrxcm 206 31 . . . cord-352379-q5inrxcm 207 1 The the DT cord-352379-q5inrxcm 207 2 so so RB cord-352379-q5inrxcm 207 3 - - HYPH cord-352379-q5inrxcm 207 4 called call VBN cord-352379-q5inrxcm 207 5 ' ' `` cord-352379-q5inrxcm 207 6 non non JJ cord-352379-q5inrxcm 207 7 - - JJ cord-352379-q5inrxcm 207 8 essential essential JJ cord-352379-q5inrxcm 207 9 ORFs orfs NN cord-352379-q5inrxcm 207 10 ' ' '' cord-352379-q5inrxcm 207 11 may may MD cord-352379-q5inrxcm 207 12 also also RB cord-352379-q5inrxcm 207 13 play play VB cord-352379-q5inrxcm 207 14 a a DT cord-352379-q5inrxcm 207 15 role role NN cord-352379-q5inrxcm 207 16 in in IN cord-352379-q5inrxcm 207 17 viral viral JJ cord-352379-q5inrxcm 207 18 pathogenesis pathogenesis NN cord-352379-q5inrxcm 207 19 . . . cord-352379-q5inrxcm 208 1 These these DT cord-352379-q5inrxcm 208 2 genes gene NNS cord-352379-q5inrxcm 208 3 are be VBP cord-352379-q5inrxcm 208 4 not not RB cord-352379-q5inrxcm 208 5 necessary necessary JJ cord-352379-q5inrxcm 208 6 for for IN cord-352379-q5inrxcm 208 7 viral viral JJ cord-352379-q5inrxcm 208 8 replication replication NN cord-352379-q5inrxcm 208 9 in in IN cord-352379-q5inrxcm 208 10 tissue tissue NN cord-352379-q5inrxcm 208 11 culture culture NN cord-352379-q5inrxcm 208 12 cells cell NNS cord-352379-q5inrxcm 208 13 , , , cord-352379-q5inrxcm 208 14 as as IN cord-352379-q5inrxcm 208 15 experimental experimental JJ cord-352379-q5inrxcm 208 16 or or CC cord-352379-q5inrxcm 208 17 natural natural JJ cord-352379-q5inrxcm 208 18 deletions deletion NNS cord-352379-q5inrxcm 208 19 of of IN cord-352379-q5inrxcm 208 20 any any DT cord-352379-q5inrxcm 208 21 one one CD cord-352379-q5inrxcm 208 22 of of IN cord-352379-q5inrxcm 208 23 these these DT cord-352379-q5inrxcm 208 24 genes gene NNS cord-352379-q5inrxcm 208 25 did do VBD cord-352379-q5inrxcm 208 26 not not RB cord-352379-q5inrxcm 208 27 affect affect VB cord-352379-q5inrxcm 208 28 the the DT cord-352379-q5inrxcm 208 29 ability ability NN cord-352379-q5inrxcm 208 30 of of IN cord-352379-q5inrxcm 208 31 the the DT cord-352379-q5inrxcm 208 32 virus virus NN cord-352379-q5inrxcm 208 33 to to TO cord-352379-q5inrxcm 208 34 replicate replicate VB cord-352379-q5inrxcm 208 35 . . . cord-352379-q5inrxcm 209 1 However however RB cord-352379-q5inrxcm 209 2 , , , cord-352379-q5inrxcm 209 3 some some DT cord-352379-q5inrxcm 209 4 of of IN cord-352379-q5inrxcm 209 5 these these DT cord-352379-q5inrxcm 209 6 deletion deletion NN cord-352379-q5inrxcm 209 7 mutants mutant NNS cord-352379-q5inrxcm 209 8 show show VBP cord-352379-q5inrxcm 209 9 much much RB cord-352379-q5inrxcm 209 10 lower low JJR cord-352379-q5inrxcm 209 11 virulence virulence NN cord-352379-q5inrxcm 209 12 than than IN cord-352379-q5inrxcm 209 13 the the DT cord-352379-q5inrxcm 209 14 wild wild JJ cord-352379-q5inrxcm 209 15 - - HYPH cord-352379-q5inrxcm 209 16 type type NN cord-352379-q5inrxcm 209 17 virus virus NN cord-352379-q5inrxcm 209 18 in in IN cord-352379-q5inrxcm 209 19 infections infection NNS cord-352379-q5inrxcm 209 20 in in IN cord-352379-q5inrxcm 209 21 animals animal NNS cord-352379-q5inrxcm 209 22 [ [ -LRB- cord-352379-q5inrxcm 209 23 19 19 CD cord-352379-q5inrxcm 209 24 ] ] -RRB- cord-352379-q5inrxcm 209 25 . . . cord-352379-q5inrxcm 210 1 tt tt NNP cord-352379-q5inrxcm 210 2 is be VBZ cord-352379-q5inrxcm 210 3 significant significant JJ cord-352379-q5inrxcm 210 4 that that IN cord-352379-q5inrxcm 210 5 SARS SARS NNP cord-352379-q5inrxcm 210 6 virus virus NN cord-352379-q5inrxcm 210 7 shows show VBZ cord-352379-q5inrxcm 210 8 significant significant JJ cord-352379-q5inrxcm 210 9 divergence divergence NN cord-352379-q5inrxcm 210 10 of of IN cord-352379-q5inrxcm 210 11 these these DT cord-352379-q5inrxcm 210 12 ORFs orf NNS cord-352379-q5inrxcm 210 13 from from IN cord-352379-q5inrxcm 210 14 other other JJ cord-352379-q5inrxcm 210 15 coronaviruses coronaviruse NNS cord-352379-q5inrxcm 210 16 . . . cord-352379-q5inrxcm 211 1 A a DT cord-352379-q5inrxcm 211 2 preliminary preliminary JJ cord-352379-q5inrxcm 211 3 report report NN cord-352379-q5inrxcm 211 4 shows show VBZ cord-352379-q5inrxcm 211 5 that that IN cord-352379-q5inrxcm 211 6 the the DT cord-352379-q5inrxcm 211 7 civet civet NN cord-352379-q5inrxcm 211 8 cat cat NN cord-352379-q5inrxcm 211 9 coronavirus coronavirus NN cord-352379-q5inrxcm 211 10 has have VBZ cord-352379-q5inrxcm 211 11 a a DT cord-352379-q5inrxcm 211 12 29nucleotide 29nucleotide CD cord-352379-q5inrxcm 211 13 deletion deletion NN cord-352379-q5inrxcm 211 14 , , , cord-352379-q5inrxcm 211 15 which which WDT cord-352379-q5inrxcm 211 16 caused cause VBD cord-352379-q5inrxcm 211 17 two two CD cord-352379-q5inrxcm 211 18 non non JJ cord-352379-q5inrxcm 211 19 - - JJ cord-352379-q5inrxcm 211 20 essential essential JJ cord-352379-q5inrxcm 211 21 ORFs orfs NN cord-352379-q5inrxcm 211 22 to to TO cord-352379-q5inrxcm 211 23 fuse fuse VB cord-352379-q5inrxcm 211 24 into into IN cord-352379-q5inrxcm 211 25 one one CD cord-352379-q5inrxcm 211 26 , , , cord-352379-q5inrxcm 211 27 creating create VBG cord-352379-q5inrxcm 211 28 a a DT cord-352379-q5inrxcm 211 29 new new JJ cord-352379-q5inrxcm 211 30 ORF orf NN cord-352379-q5inrxcm 211 31 in in IN cord-352379-q5inrxcm 211 32 the the DT cord-352379-q5inrxcm 211 33 SARS SARS NNP cord-352379-q5inrxcm 211 34 virus virus NN cord-352379-q5inrxcm 211 35 [ [ -LRB- cord-352379-q5inrxcm 211 36 30a 30a NN cord-352379-q5inrxcm 211 37 ] ] -RRB- cord-352379-q5inrxcm 211 38 . . . cord-352379-q5inrxcm 212 1 It -PRON- PRP cord-352379-q5inrxcm 212 2 will will MD cord-352379-q5inrxcm 212 3 be be VB cord-352379-q5inrxcm 212 4 very very RB cord-352379-q5inrxcm 212 5 interesting interesting JJ cord-352379-q5inrxcm 212 6 to to TO cord-352379-q5inrxcm 212 7 find find VB cord-352379-q5inrxcm 212 8 out out RP cord-352379-q5inrxcm 212 9 if if IN cord-352379-q5inrxcm 212 10 this this DT cord-352379-q5inrxcm 212 11 new new JJ cord-352379-q5inrxcm 212 12 ORF ORF NNP cord-352379-q5inrxcm 212 13 contributes contribute VBZ cord-352379-q5inrxcm 212 14 to to IN cord-352379-q5inrxcm 212 15 the the DT cord-352379-q5inrxcm 212 16 virulence virulence NN cord-352379-q5inrxcm 212 17 of of IN cord-352379-q5inrxcm 212 18 the the DT cord-352379-q5inrxcm 212 19 SARS SARS NNP cord-352379-q5inrxcm 212 20 virus virus NN cord-352379-q5inrxcm 212 21 . . . cord-352379-q5inrxcm 213 1 Other other JJ cord-352379-q5inrxcm 213 2 viral viral JJ cord-352379-q5inrxcm 213 3 gene gene NN cord-352379-q5inrxcm 213 4 products product NNS cord-352379-q5inrxcm 213 5 may may MD cord-352379-q5inrxcm 213 6 also also RB cord-352379-q5inrxcm 213 7 alter alter VB cord-352379-q5inrxcm 213 8 cellular cellular JJ cord-352379-q5inrxcm 213 9 responses response NNS cord-352379-q5inrxcm 213 10 to to IN cord-352379-q5inrxcm 213 11 the the DT cord-352379-q5inrxcm 213 12 viral viral JJ cord-352379-q5inrxcm 213 13 infection infection NN cord-352379-q5inrxcm 213 14 . . . cord-352379-q5inrxcm 214 1 For for IN cord-352379-q5inrxcm 214 2 example example NN cord-352379-q5inrxcm 214 3 , , , cord-352379-q5inrxcm 214 4 M M NNP cord-352379-q5inrxcm 214 5 protein protein NN cord-352379-q5inrxcm 214 6 of of IN cord-352379-q5inrxcm 214 7 TGEV TGEV NNP cord-352379-q5inrxcm 214 8 can can MD cord-352379-q5inrxcm 214 9 induce induce VB cord-352379-q5inrxcm 214 10 interferon interferon NN cord-352379-q5inrxcm 214 11 [ [ -LRB- cord-352379-q5inrxcm 214 12 15 15 CD cord-352379-q5inrxcm 214 13 ] ] -RRB- cord-352379-q5inrxcm 214 14 , , , cord-352379-q5inrxcm 214 15 and and CC cord-352379-q5inrxcm 214 16 E e NN cord-352379-q5inrxcm 214 17 protein protein NN cord-352379-q5inrxcm 214 18 of of IN cord-352379-q5inrxcm 214 19 MHV MHV NNP cord-352379-q5inrxcm 214 20 can can MD cord-352379-q5inrxcm 214 21 induce induce VB cord-352379-q5inrxcm 214 22 apoptosis apoptosis NN cord-352379-q5inrxcm 214 23 [ [ -LRB- cord-352379-q5inrxcm 214 24 3 3 CD cord-352379-q5inrxcm 214 25 ] ] -RRB- cord-352379-q5inrxcm 214 26 . . . cord-352379-q5inrxcm 215 1 They -PRON- PRP cord-352379-q5inrxcm 215 2 may may MD cord-352379-q5inrxcm 215 3 modulate modulate VB cord-352379-q5inrxcm 215 4 the the DT cord-352379-q5inrxcm 215 5 course course NN cord-352379-q5inrxcm 215 6 of of IN cord-352379-q5inrxcm 215 7 viral viral JJ cord-352379-q5inrxcm 215 8 infection infection NN cord-352379-q5inrxcm 215 9 . . . cord-352379-q5inrxcm 216 1 Another another DT cord-352379-q5inrxcm 216 2 important important JJ cord-352379-q5inrxcm 216 3 issue issue NN cord-352379-q5inrxcm 216 4 in in IN cord-352379-q5inrxcm 216 5 the the DT cord-352379-q5inrxcm 216 6 pathogenesis pathogenesis NN cord-352379-q5inrxcm 216 7 of of IN cord-352379-q5inrxcm 216 8 SARS SARS NNP cord-352379-q5inrxcm 216 9 virus virus NN cord-352379-q5inrxcm 216 10 is be VBZ cord-352379-q5inrxcm 216 11 whether whether IN cord-352379-q5inrxcm 216 12 the the DT cord-352379-q5inrxcm 216 13 virus virus NN cord-352379-q5inrxcm 216 14 can can MD cord-352379-q5inrxcm 216 15 cause cause VB cord-352379-q5inrxcm 216 16 chronic chronic JJ cord-352379-q5inrxcm 216 17 persistent persistent JJ cord-352379-q5inrxcm 216 18 infection infection NN cord-352379-q5inrxcm 216 19 . . . cord-352379-q5inrxcm 217 1 This this DT cord-352379-q5inrxcm 217 2 issue issue NN cord-352379-q5inrxcm 217 3 concerns concern VBZ cord-352379-q5inrxcm 217 4 the the DT cord-352379-q5inrxcm 217 5 possible possible JJ cord-352379-q5inrxcm 217 6 presence presence NN cord-352379-q5inrxcm 217 7 of of IN cord-352379-q5inrxcm 217 8 chronic chronic JJ cord-352379-q5inrxcm 217 9 carriers carrier NNS cord-352379-q5inrxcm 217 10 , , , cord-352379-q5inrxcm 217 11 who who WP cord-352379-q5inrxcm 217 12 may may MD cord-352379-q5inrxcm 217 13 serve serve VB cord-352379-q5inrxcm 217 14 as as IN cord-352379-q5inrxcm 217 15 the the DT cord-352379-q5inrxcm 217 16 source source NN cord-352379-q5inrxcm 217 17 of of IN cord-352379-q5inrxcm 217 18 continuing continue VBG cord-352379-q5inrxcm 217 19 SARS SARS NNP cord-352379-q5inrxcm 217 20 outbreaks outbreak NNS cord-352379-q5inrxcm 217 21 . . . cord-352379-q5inrxcm 218 1 Although although IN cord-352379-q5inrxcm 218 2 human human JJ cord-352379-q5inrxcm 218 3 coronaviruses coronaviruse NNS cord-352379-q5inrxcm 218 4 typically typically RB cord-352379-q5inrxcm 218 5 cause cause VBP cord-352379-q5inrxcm 218 6 short short JJ cord-352379-q5inrxcm 218 7 , , , cord-352379-q5inrxcm 218 8 self self NN cord-352379-q5inrxcm 218 9 - - HYPH cord-352379-q5inrxcm 218 10 limiting limit VBG cord-352379-q5inrxcm 218 11 illnesses illness NNS cord-352379-q5inrxcm 218 12 , , , cord-352379-q5inrxcm 218 13 most most JJS cord-352379-q5inrxcm 218 14 of of IN cord-352379-q5inrxcm 218 15 the the DT cord-352379-q5inrxcm 218 16 animal animal NN cord-352379-q5inrxcm 218 17 coronaviruses coronaviruse NNS cord-352379-q5inrxcm 218 18 are be VBP cord-352379-q5inrxcm 218 19 known know VBN cord-352379-q5inrxcm 218 20 to to TO cord-352379-q5inrxcm 218 21 cause cause VB cord-352379-q5inrxcm 218 22 persistent persistent JJ cord-352379-q5inrxcm 218 23 infection infection NN cord-352379-q5inrxcm 218 24 . . . cord-352379-q5inrxcm 219 1 The the DT cord-352379-q5inrxcm 219 2 best well RBS cord-352379-q5inrxcm 219 3 studied study VBN cord-352379-q5inrxcm 219 4 coronavirus coronavirus NN cord-352379-q5inrxcm 219 5 in in IN cord-352379-q5inrxcm 219 6 this this DT cord-352379-q5inrxcm 219 7 regard regard NN cord-352379-q5inrxcm 219 8 is be VBZ cord-352379-q5inrxcm 219 9 feline feline JJ cord-352379-q5inrxcm 219 10 coronavirus coronavirus NN cord-352379-q5inrxcm 219 11 FECoV fecov NN cord-352379-q5inrxcm 219 12 ; ; , cord-352379-q5inrxcm 219 13 infected infected JJ cord-352379-q5inrxcm 219 14 animals animal NNS cord-352379-q5inrxcm 219 15 can can MD cord-352379-q5inrxcm 219 16 continue continue VB cord-352379-q5inrxcm 219 17 to to TO cord-352379-q5inrxcm 219 18 shed shed VB cord-352379-q5inrxcm 219 19 virus virus NN cord-352379-q5inrxcm 219 20 tbr tbr NN cord-352379-q5inrxcm 219 21 as as RB cord-352379-q5inrxcm 219 22 long long RB cord-352379-q5inrxcm 219 23 as as IN cord-352379-q5inrxcm 219 24 7 7 CD cord-352379-q5inrxcm 219 25 months month NNS cord-352379-q5inrxcm 219 26 after after IN cord-352379-q5inrxcm 219 27 infection infection NN cord-352379-q5inrxcm 219 28 , , , cord-352379-q5inrxcm 219 29 even even RB cord-352379-q5inrxcm 219 30 though though IN cord-352379-q5inrxcm 219 31 these these DT cord-352379-q5inrxcm 219 32 animals animal NNS cord-352379-q5inrxcm 219 33 do do VBP cord-352379-q5inrxcm 219 34 not not RB cord-352379-q5inrxcm 219 35 show show VB cord-352379-q5inrxcm 219 36 symptoms symptom NNS cord-352379-q5inrxcm 219 37 [ [ -LRB- cord-352379-q5inrxcm 219 38 34 34 CD cord-352379-q5inrxcm 219 39 ] ] -RRB- cord-352379-q5inrxcm 219 40 . . . cord-352379-q5inrxcm 220 1 TGEV TGEV NNP cord-352379-q5inrxcm 220 2 also also RB cord-352379-q5inrxcm 220 3 shows show VBZ cord-352379-q5inrxcm 220 4 a a DT cord-352379-q5inrxcm 220 5 similar similar JJ cord-352379-q5inrxcm 220 6 tendency tendency NN cord-352379-q5inrxcm 220 7 , , , cord-352379-q5inrxcm 220 8 in in IN cord-352379-q5inrxcm 220 9 which which WDT cord-352379-q5inrxcm 220 10 the the DT cord-352379-q5inrxcm 220 11 virus virus NN cord-352379-q5inrxcm 220 12 can can MD cord-352379-q5inrxcm 220 13 be be VB cord-352379-q5inrxcm 220 14 detected detect VBN cord-352379-q5inrxcm 220 15 in in IN cord-352379-q5inrxcm 220 16 the the DT cord-352379-q5inrxcm 220 17 respiratory respiratory JJ cord-352379-q5inrxcm 220 18 tract tract NN cord-352379-q5inrxcm 220 19 of of IN cord-352379-q5inrxcm 220 20 the the DT cord-352379-q5inrxcm 220 21 infected infected JJ cord-352379-q5inrxcm 220 22 animals animal NNS cord-352379-q5inrxcm 220 23 several several JJ cord-352379-q5inrxcm 220 24 months month NNS cord-352379-q5inrxcm 220 25 after after IN cord-352379-q5inrxcm 220 26 infection infection NN cord-352379-q5inrxcm 220 27 [ [ -LRB- cord-352379-q5inrxcm 220 28 40 40 CD cord-352379-q5inrxcm 220 29 , , , cord-352379-q5inrxcm 220 30 74 74 CD cord-352379-q5inrxcm 220 31 ] ] -RRB- cord-352379-q5inrxcm 220 32 . . . cord-352379-q5inrxcm 221 1 MHV MHV NNP cord-352379-q5inrxcm 221 2 can can MD cord-352379-q5inrxcm 221 3 persist persist VB cord-352379-q5inrxcm 221 4 in in IN cord-352379-q5inrxcm 221 5 the the DT cord-352379-q5inrxcm 221 6 central central JJ cord-352379-q5inrxcm 221 7 nervous nervous JJ cord-352379-q5inrxcm 221 8 system system NN cord-352379-q5inrxcm 221 9 many many JJ cord-352379-q5inrxcm 221 10 months month NNS cord-352379-q5inrxcm 221 11 after after IN cord-352379-q5inrxcm 221 12 intracraniat intracraniat NNP cord-352379-q5inrxcm 221 13 inoculation inoculation NN cord-352379-q5inrxcm 221 14 [ [ -LRB- cord-352379-q5inrxcm 221 15 40 40 CD cord-352379-q5inrxcm 221 16 ] ] -RRB- cord-352379-q5inrxcm 221 17 . . . cord-352379-q5inrxcm 222 1 Thus thus RB cord-352379-q5inrxcm 222 2 , , , cord-352379-q5inrxcm 222 3 the the DT cord-352379-q5inrxcm 222 4 ability ability NN cord-352379-q5inrxcm 222 5 to to TO cord-352379-q5inrxcm 222 6 persist persist VB cord-352379-q5inrxcm 222 7 is be VBZ cord-352379-q5inrxcm 222 8 a a DT cord-352379-q5inrxcm 222 9 common common JJ cord-352379-q5inrxcm 222 10 feature feature NN cord-352379-q5inrxcm 222 11 of of IN cord-352379-q5inrxcm 222 12 most most JJS cord-352379-q5inrxcm 222 13 coronaviruses coronaviruse NNS cord-352379-q5inrxcm 222 14 under under IN cord-352379-q5inrxcm 222 15 some some DT cord-352379-q5inrxcm 222 16 conditions condition NNS cord-352379-q5inrxcm 222 17 . . . cord-352379-q5inrxcm 223 1 SARS SARS NNP cord-352379-q5inrxcm 223 2 virus virus NN cord-352379-q5inrxcm 223 3 may may MD cord-352379-q5inrxcm 223 4 also also RB cord-352379-q5inrxcm 223 5 have have VB cord-352379-q5inrxcm 223 6 this this DT cord-352379-q5inrxcm 223 7 property property NN cord-352379-q5inrxcm 223 8 . . . cord-352379-q5inrxcm 224 1 So so RB cord-352379-q5inrxcm 224 2 far far RB cord-352379-q5inrxcm 224 3 , , , cord-352379-q5inrxcm 224 4 viral viral JJ cord-352379-q5inrxcm 224 5 RNA RNA NNP cord-352379-q5inrxcm 224 6 reportedly reportedly RB cord-352379-q5inrxcm 224 7 has have VBZ cord-352379-q5inrxcm 224 8 been be VBN cord-352379-q5inrxcm 224 9 detected detect VBN cord-352379-q5inrxcm 224 10 in in IN cord-352379-q5inrxcm 224 11 patients patient NNS cord-352379-q5inrxcm 224 12 ' ' POS cord-352379-q5inrxcm 224 13 stool stool NN cord-352379-q5inrxcm 224 14 more more JJR cord-352379-q5inrxcm 224 15 than than IN cord-352379-q5inrxcm 224 16 30 30 CD cord-352379-q5inrxcm 224 17 days day NNS cord-352379-q5inrxcm 224 18 after after IN cord-352379-q5inrxcm 224 19 infection infection NN cord-352379-q5inrxcm 224 20 ( ( -LRB- cord-352379-q5inrxcm 224 21 World World NNP cord-352379-q5inrxcm 224 22 Health Health NNP cord-352379-q5inrxcm 224 23 Organization Organization NNP cord-352379-q5inrxcm 224 24 Bulletin Bulletin NNP cord-352379-q5inrxcm 224 25 ) ) -RRB- cord-352379-q5inrxcm 224 26 . . . cord-352379-q5inrxcm 225 1 Coronavirus Coronavirus NNP cord-352379-q5inrxcm 225 2 primarily primarily RB cord-352379-q5inrxcm 225 3 infects infect VBZ cord-352379-q5inrxcm 225 4 the the DT cord-352379-q5inrxcm 225 5 epithelial epithelial JJ cord-352379-q5inrxcm 225 6 cells cell NNS cord-352379-q5inrxcm 225 7 of of IN cord-352379-q5inrxcm 225 8 the the DT cord-352379-q5inrxcm 225 9 GI gi NN cord-352379-q5inrxcm 225 10 and and CC cord-352379-q5inrxcm 225 11 respiratory respiratory JJ cord-352379-q5inrxcm 225 12 tracts tract NNS cord-352379-q5inrxcm 225 13 , , , cord-352379-q5inrxcm 225 14 but but CC cord-352379-q5inrxcm 225 15 the the DT cord-352379-q5inrxcm 225 16 virus virus NN cord-352379-q5inrxcm 225 17 can can MD cord-352379-q5inrxcm 225 18 replicate replicate VB cord-352379-q5inrxcm 225 19 in in IN cord-352379-q5inrxcm 225 20 many many JJ cord-352379-q5inrxcm 225 21 cell cell NN cord-352379-q5inrxcm 225 22 types type NNS cord-352379-q5inrxcm 225 23 , , , cord-352379-q5inrxcm 225 24 particularly particularly RB cord-352379-q5inrxcm 225 25 macrophages macrophage NNS cord-352379-q5inrxcm 225 26 . . . cord-352379-q5inrxcm 226 1 SARS SARS NNP cord-352379-q5inrxcm 226 2 virus virus NN cord-352379-q5inrxcm 226 3 also also RB cord-352379-q5inrxcm 226 4 infects infect VBZ cord-352379-q5inrxcm 226 5 a a DT cord-352379-q5inrxcm 226 6 wide wide JJ cord-352379-q5inrxcm 226 7 spectrum spectrum NN cord-352379-q5inrxcm 226 8 of of IN cord-352379-q5inrxcm 226 9 cell cell NN cord-352379-q5inrxcm 226 10 types type NNS cord-352379-q5inrxcm 226 11 ; ; : cord-352379-q5inrxcm 226 12 it -PRON- PRP cord-352379-q5inrxcm 226 13 has have VBZ cord-352379-q5inrxcm 226 14 been be VBN cord-352379-q5inrxcm 226 15 detected detect VBN cord-352379-q5inrxcm 226 16 in in IN cord-352379-q5inrxcm 226 17 the the DT cord-352379-q5inrxcm 226 18 blood blood NN cord-352379-q5inrxcm 226 19 , , , cord-352379-q5inrxcm 226 20 lung lung NN cord-352379-q5inrxcm 226 21 , , , cord-352379-q5inrxcm 226 22 liver liver NN cord-352379-q5inrxcm 226 23 and and CC cord-352379-q5inrxcm 226 24 kidney kidney NN cord-352379-q5inrxcm 226 25 , , , cord-352379-q5inrxcm 226 26 and and CC cord-352379-q5inrxcm 226 27 in in IN cord-352379-q5inrxcm 226 28 various various JJ cord-352379-q5inrxcm 226 29 bodily bodily JJ cord-352379-q5inrxcm 226 30 secretions secretion NNS cord-352379-q5inrxcm 226 31 , , , cord-352379-q5inrxcm 226 32 including include VBG cord-352379-q5inrxcm 226 33 stool stool NN cord-352379-q5inrxcm 226 34 and and CC cord-352379-q5inrxcm 226 35 urine urine NN cord-352379-q5inrxcm 226 36 [ [ -LRB- cord-352379-q5inrxcm 226 37 41 41 CD cord-352379-q5inrxcm 226 38 ] ] -RRB- cord-352379-q5inrxcm 226 39 . . . cord-352379-q5inrxcm 227 1 Thus thus RB cord-352379-q5inrxcm 227 2 , , , cord-352379-q5inrxcm 227 3 SARS SARS NNP cord-352379-q5inrxcm 227 4 virus virus NN cord-352379-q5inrxcm 227 5 may may MD cord-352379-q5inrxcm 227 6 induce induce VB cord-352379-q5inrxcm 227 7 systemic systemic JJ cord-352379-q5inrxcm 227 8 infection infection NN cord-352379-q5inrxcm 227 9 . . . cord-352379-q5inrxcm 228 1 The the DT cord-352379-q5inrxcm 228 2 primary primary JJ cord-352379-q5inrxcm 228 3 determinant determinant NN cord-352379-q5inrxcm 228 4 of of IN cord-352379-q5inrxcm 228 5 target target NN cord-352379-q5inrxcm 228 6 cell cell NN cord-352379-q5inrxcm 228 7 specificity specificity NN cord-352379-q5inrxcm 228 8 of of IN cord-352379-q5inrxcm 228 9 the the DT cord-352379-q5inrxcm 228 10 virus virus NN cord-352379-q5inrxcm 228 11 is be VBZ cord-352379-q5inrxcm 228 12 the the DT cord-352379-q5inrxcm 228 13 nature nature NN cord-352379-q5inrxcm 228 14 of of IN cord-352379-q5inrxcm 228 15 its -PRON- PRP$ cord-352379-q5inrxcm 228 16 cellular cellular JJ cord-352379-q5inrxcm 228 17 receptors receptor NNS cord-352379-q5inrxcm 228 18 . . . cord-352379-q5inrxcm 229 1 Type type NN cord-352379-q5inrxcm 230 1 I -PRON- PRP cord-352379-q5inrxcm 230 2 coronaviruses coronaviruse VBZ cord-352379-q5inrxcm 231 1 use use VB cord-352379-q5inrxcm 231 2 aminopeptidase aminopeptidase NNP cord-352379-q5inrxcm 231 3 N N NNP cord-352379-q5inrxcm 231 4 ( ( -LRB- cord-352379-q5inrxcm 231 5 CD CD NNP cord-352379-q5inrxcm 231 6 13 13 CD cord-352379-q5inrxcm 231 7 ) ) -RRB- cord-352379-q5inrxcm 231 8 of of IN cord-352379-q5inrxcm 231 9 various various JJ cord-352379-q5inrxcm 231 10 animal animal NN cord-352379-q5inrxcm 231 11 species specie NNS cord-352379-q5inrxcm 231 12 as as IN cord-352379-q5inrxcm 231 13 receptors receptor NNS cord-352379-q5inrxcm 231 14 in in IN cord-352379-q5inrxcm 231 15 a a DT cord-352379-q5inrxcm 231 16 species species NN cord-352379-q5inrxcm 231 17 - - HYPH cord-352379-q5inrxcm 231 18 specific specific JJ cord-352379-q5inrxcm 231 19 manner manner NN cord-352379-q5inrxcm 231 20 [ [ -LRB- cord-352379-q5inrxcm 231 21 20 20 CD cord-352379-q5inrxcm 231 22 , , , cord-352379-q5inrxcm 231 23 80 80 CD cord-352379-q5inrxcm 231 24 ] ] -RRB- cord-352379-q5inrxcm 231 25 , , , cord-352379-q5inrxcm 231 26 while while IN cord-352379-q5inrxcm 231 27 a a DT cord-352379-q5inrxcm 231 28 type type NN cord-352379-q5inrxcm 231 29 II ii CD cord-352379-q5inrxcm 231 30 coronavirus coronavirus NN cord-352379-q5inrxcm 231 31 ( ( -LRB- cord-352379-q5inrxcm 231 32 MHV MHV NNP cord-352379-q5inrxcm 231 33 ) ) -RRB- cord-352379-q5inrxcm 231 34 uses use VBZ cord-352379-q5inrxcm 231 35 the the DT cord-352379-q5inrxcm 231 36 carcinoembryonic carcinoembryonic NNP cord-352379-q5inrxcm 231 37 antigen antigen NN cord-352379-q5inrxcm 231 38 as as IN cord-352379-q5inrxcm 231 39 receNor receNor NNP cord-352379-q5inrxcm 231 40 [ [ -LRB- cord-352379-q5inrxcm 231 41 79 79 CD cord-352379-q5inrxcm 231 42 ] ] -RRB- cord-352379-q5inrxcm 231 43 . . . cord-352379-q5inrxcm 232 1 The the DT cord-352379-q5inrxcm 232 2 receptors receptor NNS cord-352379-q5inrxcm 232 3 for for IN cord-352379-q5inrxcm 232 4 type type NN cord-352379-q5inrxcm 232 5 III iii CD cord-352379-q5inrxcm 232 6 viruses virus NNS cord-352379-q5inrxcm 232 7 and and CC cord-352379-q5inrxcm 232 8 SARS SARS NNP cord-352379-q5inrxcm 232 9 virus virus NN cord-352379-q5inrxcm 232 10 are be VBP cord-352379-q5inrxcm 232 11 not not RB cord-352379-q5inrxcm 232 12 yet yet RB cord-352379-q5inrxcm 232 13 known know VBN cord-352379-q5inrxcm 232 14 . . . cord-352379-q5inrxcm 233 1 It -PRON- PRP cord-352379-q5inrxcm 233 2 should should MD cord-352379-q5inrxcm 233 3 be be VB cord-352379-q5inrxcm 233 4 noted note VBN cord-352379-q5inrxcm 233 5 that that IN cord-352379-q5inrxcm 233 6 the the DT cord-352379-q5inrxcm 233 7 virus virus NN cord-352379-q5inrxcm 233 8 easily easily RB cord-352379-q5inrxcm 233 9 adapts adapt VBZ cord-352379-q5inrxcm 233 10 to to IN cord-352379-q5inrxcm 233 11 cell cell NN cord-352379-q5inrxcm 233 12 lines line NNS cord-352379-q5inrxcm 233 13 of of IN cord-352379-q5inrxcm 233 14 different different JJ cord-352379-q5inrxcm 233 15 animal animal NN cord-352379-q5inrxcm 233 16 species specie NNS cord-352379-q5inrxcm 233 17 , , , cord-352379-q5inrxcm 233 18 probably probably RB cord-352379-q5inrxcm 233 19 by by IN cord-352379-q5inrxcm 233 20 using use VBG cord-352379-q5inrxcm 233 21 other other JJ cord-352379-q5inrxcm 233 22 related related JJ cord-352379-q5inrxcm 233 23 molecules molecule NNS cord-352379-q5inrxcm 233 24 as as IN cord-352379-q5inrxcm 233 25 a a DT cord-352379-q5inrxcm 233 26 receptor receptor NN cord-352379-q5inrxcm 233 27 [ [ -LRB- cord-352379-q5inrxcm 233 28 9 9 CD cord-352379-q5inrxcm 233 29 ] ] -RRB- cord-352379-q5inrxcm 233 30 . . . cord-352379-q5inrxcm 234 1 Thus thus RB cord-352379-q5inrxcm 234 2 , , , cord-352379-q5inrxcm 234 3 the the DT cord-352379-q5inrxcm 234 4 specificity specificity NN cord-352379-q5inrxcm 234 5 of of IN cord-352379-q5inrxcm 234 6 the the DT cord-352379-q5inrxcm 234 7 spike spike NN cord-352379-q5inrxcm 234 8 - - HYPH cord-352379-q5inrxcm 234 9 receptor receptor NN cord-352379-q5inrxcm 234 10 interaction interaction NN cord-352379-q5inrxcm 234 11 may may MD cord-352379-q5inrxcm 234 12 not not RB cord-352379-q5inrxcm 234 13 be be VB cord-352379-q5inrxcm 234 14 very very RB cord-352379-q5inrxcm 234 15 rigid rigid JJ cord-352379-q5inrxcm 234 16 . . . cord-352379-q5inrxcm 235 1 Interruption interruption NN cord-352379-q5inrxcm 235 2 of of IN cord-352379-q5inrxcm 235 3 the the DT cord-352379-q5inrxcm 235 4 binding binding NN cord-352379-q5inrxcm 235 5 between between IN cord-352379-q5inrxcm 235 6 the the DT cord-352379-q5inrxcm 235 7 spike spike NN cord-352379-q5inrxcm 235 8 protein protein NN cord-352379-q5inrxcm 235 9 and and CC cord-352379-q5inrxcm 235 10 the the DT cord-352379-q5inrxcm 235 11 receptor receptor NN cord-352379-q5inrxcm 235 12 will will MD cord-352379-q5inrxcm 235 13 be be VB cord-352379-q5inrxcm 235 14 a a DT cord-352379-q5inrxcm 235 15 potential potential JJ cord-352379-q5inrxcm 235 16 means mean NNS cord-352379-q5inrxcm 235 17 of of IN cord-352379-q5inrxcm 235 18 inhibiting inhibit VBG cord-352379-q5inrxcm 235 19 viral viral JJ cord-352379-q5inrxcm 235 20 infection infection NN cord-352379-q5inrxcm 235 21 . . . cord-352379-q5inrxcm 236 1 The the DT cord-352379-q5inrxcm 236 2 next next JJ cord-352379-q5inrxcm 236 3 step step NN cord-352379-q5inrxcm 236 4 of of IN cord-352379-q5inrxcm 236 5 virus virus NN cord-352379-q5inrxcm 236 6 infection infection NN cord-352379-q5inrxcm 236 7 is be VBZ cord-352379-q5inrxcm 236 8 virus virus NN cord-352379-q5inrxcm 236 9 entry entry NN cord-352379-q5inrxcm 236 10 . . . cord-352379-q5inrxcm 237 1 The the DT cord-352379-q5inrxcm 237 2 mode mode NN cord-352379-q5inrxcm 237 3 of of IN cord-352379-q5inrxcm 237 4 virus virus NN cord-352379-q5inrxcm 237 5 entry entry NN cord-352379-q5inrxcm 237 6 for for IN cord-352379-q5inrxcm 237 7 coronavirus coronavirus NN cord-352379-q5inrxcm 237 8 may may MD cord-352379-q5inrxcm 237 9 vary vary VB cord-352379-q5inrxcm 237 10 between between IN cord-352379-q5inrxcm 237 11 different different JJ cord-352379-q5inrxcm 237 12 viruses virus NNS cord-352379-q5inrxcm 237 13 . . . cord-352379-q5inrxcm 238 1 Although although IN cord-352379-q5inrxcm 238 2 most most JJS cord-352379-q5inrxcm 238 3 viruses virus NNS cord-352379-q5inrxcm 238 4 appear appear VBP cord-352379-q5inrxcm 238 5 to to TO cord-352379-q5inrxcm 238 6 enter enter VB cord-352379-q5inrxcm 238 7 cells cell NNS cord-352379-q5inrxcm 238 8 by by IN cord-352379-q5inrxcm 238 9 fusion fusion NN cord-352379-q5inrxcm 238 10 at at IN cord-352379-q5inrxcm 238 11 the the DT cord-352379-q5inrxcm 238 12 plasma plasma NN cord-352379-q5inrxcm 238 13 membranes membrane NNS cord-352379-q5inrxcm 238 14 , , , cord-352379-q5inrxcm 238 15 some some DT cord-352379-q5inrxcm 238 16 viruses virus NNS cord-352379-q5inrxcm 238 17 may may MD cord-352379-q5inrxcm 238 18 enter enter VB cord-352379-q5inrxcm 238 19 cells cell NNS cord-352379-q5inrxcm 238 20 by by IN cord-352379-q5inrxcm 238 21 acidic acidic JJ cord-352379-q5inrxcm 238 22 pH ph NN cord-352379-q5inrxcm 238 23 - - HYPH cord-352379-q5inrxcm 238 24 dependent dependent JJ cord-352379-q5inrxcm 238 25 endocytosis endocytosis NN cord-352379-q5inrxcm 238 26 . . . cord-352379-q5inrxcm 239 1 Regardless regardless RB cord-352379-q5inrxcm 239 2 , , , cord-352379-q5inrxcm 239 3 the the DT cord-352379-q5inrxcm 239 4 fusion fusion NN cord-352379-q5inrxcm 239 5 activity activity NN cord-352379-q5inrxcm 239 6 is be VBZ cord-352379-q5inrxcm 239 7 likely likely RB cord-352379-q5inrxcm 239 8 important important JJ cord-352379-q5inrxcm 239 9 for for IN cord-352379-q5inrxcm 239 10 virus virus NN cord-352379-q5inrxcm 239 11 entry entry NN cord-352379-q5inrxcm 239 12 . . . cord-352379-q5inrxcm 240 1 Several several JJ cord-352379-q5inrxcm 240 2 functional functional JJ cord-352379-q5inrxcm 240 3 domains domain NNS cord-352379-q5inrxcm 240 4 , , , cord-352379-q5inrxcm 240 5 including include VBG cord-352379-q5inrxcm 240 6 the the DT cord-352379-q5inrxcm 240 7 heptad heptad NN cord-352379-q5inrxcm 240 8 repeat repeat NN cord-352379-q5inrxcm 240 9 , , , cord-352379-q5inrxcm 240 10 which which WDT cord-352379-q5inrxcm 240 11 is be VBZ cord-352379-q5inrxcm 240 12 important important JJ cord-352379-q5inrxcm 240 13 for for IN cord-352379-q5inrxcm 240 14 oligomerization oligomerization NN cord-352379-q5inrxcm 240 15 of of IN cord-352379-q5inrxcm 240 16 the the DT cord-352379-q5inrxcm 240 17 spike spike NN cord-352379-q5inrxcm 240 18 protein protein NN cord-352379-q5inrxcm 240 19 , , , cord-352379-q5inrxcm 240 20 the the DT cord-352379-q5inrxcm 240 21 putative putative JJ cord-352379-q5inrxcm 240 22 fusion fusion NN cord-352379-q5inrxcm 240 23 peptide peptide NN cord-352379-q5inrxcm 240 24 , , , cord-352379-q5inrxcm 240 25 and and CC cord-352379-q5inrxcm 240 26 the the DT cord-352379-q5inrxcm 240 27 receptor receptor NN cord-352379-q5inrxcm 240 28 - - HYPH cord-352379-q5inrxcm 240 29 binding bind VBG cord-352379-q5inrxcm 240 30 domain domain NN cord-352379-q5inrxcm 240 31 of of IN cord-352379-q5inrxcm 240 32 the the DT cord-352379-q5inrxcm 240 33 S S NNP cord-352379-q5inrxcm 240 34 protein protein NN cord-352379-q5inrxcm 240 35 , , , cord-352379-q5inrxcm 240 36 will will MD cord-352379-q5inrxcm 240 37 be be VB cord-352379-q5inrxcm 240 38 good good JJ cord-352379-q5inrxcm 240 39 targets target NNS cord-352379-q5inrxcm 240 40 for for IN cord-352379-q5inrxcm 240 41 antivirals antiviral NNS cord-352379-q5inrxcm 240 42 . . . cord-352379-q5inrxcm 241 1 Macromolecular macromolecular JJ cord-352379-q5inrxcm 241 2 synthesis synthesis NN cord-352379-q5inrxcm 241 3 , , , cord-352379-q5inrxcm 241 4 including include VBG cord-352379-q5inrxcm 241 5 transcription transcription NN cord-352379-q5inrxcm 241 6 , , , cord-352379-q5inrxcm 241 7 translation translation NN cord-352379-q5inrxcm 241 8 and and CC cord-352379-q5inrxcm 241 9 protein protein NN cord-352379-q5inrxcm 241 10 processing processing NN cord-352379-q5inrxcm 241 11 , , , cord-352379-q5inrxcm 241 12 offers offer VBZ cord-352379-q5inrxcm 241 13 many many JJ cord-352379-q5inrxcm 241 14 potential potential JJ cord-352379-q5inrxcm 241 15 molecular molecular JJ cord-352379-q5inrxcm 241 16 targets target NNS cord-352379-q5inrxcm 241 17 as as RB cord-352379-q5inrxcm 241 18 well well RB cord-352379-q5inrxcm 241 19 . . . cord-352379-q5inrxcm 242 1 Most most RBS cord-352379-q5inrxcm 242 2 notably notably RB cord-352379-q5inrxcm 242 3 , , , cord-352379-q5inrxcm 242 4 proteases protease NNS cord-352379-q5inrxcm 242 5 , , , cord-352379-q5inrxcm 242 6 RNAdependent RNAdependent NNP cord-352379-q5inrxcm 242 7 RNA RNA NNP cord-352379-q5inrxcm 242 8 polymerases polymerase NNS cord-352379-q5inrxcm 242 9 ( ( -LRB- cord-352379-q5inrxcm 242 10 RdRP RdRP NNP cord-352379-q5inrxcm 242 11 ) ) -RRB- cord-352379-q5inrxcm 242 12 and and CC cord-352379-q5inrxcm 242 13 helicases helicase NNS cord-352379-q5inrxcm 242 14 are be VBP cord-352379-q5inrxcm 242 15 good good JJ cord-352379-q5inrxcm 242 16 targets target NNS cord-352379-q5inrxcm 242 17 . . . cord-352379-q5inrxcm 243 1 Unfortunately unfortunately RB cord-352379-q5inrxcm 243 2 , , , cord-352379-q5inrxcm 243 3 in in IN cord-352379-q5inrxcm 243 4 vitro vitro FW cord-352379-q5inrxcm 243 5 RdRP rdrp NN cord-352379-q5inrxcm 243 6 assays assay NNS cord-352379-q5inrxcm 243 7 are be VBP cord-352379-q5inrxcm 243 8 still still RB cord-352379-q5inrxcm 243 9 neither neither CC cord-352379-q5inrxcm 243 10 efficient efficient JJ cord-352379-q5inrxcm 243 11 nor nor CC cord-352379-q5inrxcm 243 12 specific specific JJ cord-352379-q5inrxcm 243 13 , , , cord-352379-q5inrxcm 243 14 precluding preclude VBG cord-352379-q5inrxcm 243 15 their -PRON- PRP$ cord-352379-q5inrxcm 243 16 use use NN cord-352379-q5inrxcm 243 17 as as IN cord-352379-q5inrxcm 243 18 a a DT cord-352379-q5inrxcm 243 19 molecular molecular JJ cord-352379-q5inrxcm 243 20 tool tool NN cord-352379-q5inrxcm 243 21 for for IN cord-352379-q5inrxcm 243 22 drug drug NN cord-352379-q5inrxcm 243 23 screening screening NN cord-352379-q5inrxcm 243 24 . . . cord-352379-q5inrxcm 244 1 In in IN cord-352379-q5inrxcm 244 2 vitro vitro FW cord-352379-q5inrxcm 244 3 protease protease NN cord-352379-q5inrxcm 244 4 assays assay NNS cord-352379-q5inrxcm 244 5 for for IN cord-352379-q5inrxcm 244 6 both both DT cord-352379-q5inrxcm 244 7 3CLpro 3clpro CD cord-352379-q5inrxcm 245 1 and and CC cord-352379-q5inrxcm 245 2 PLpro PLpro NNP cord-352379-q5inrxcm 245 3 , , , cord-352379-q5inrxcm 245 4 in in IN cord-352379-q5inrxcm 245 5 contrast contrast NN cord-352379-q5inrxcm 245 6 , , , cord-352379-q5inrxcm 245 7 are be VBP cord-352379-q5inrxcm 245 8 well well RB cord-352379-q5inrxcm 245 9 established establish VBN cord-352379-q5inrxcm 245 10 [ [ -LRB- cord-352379-q5inrxcm 245 11 33 33 CD cord-352379-q5inrxcm 245 12 , , , cord-352379-q5inrxcm 245 13 83 83 CD cord-352379-q5inrxcm 245 14 ] ] -RRB- cord-352379-q5inrxcm 245 15 . . . cord-352379-q5inrxcm 246 1 The the DT cord-352379-q5inrxcm 246 2 protease protease NN cord-352379-q5inrxcm 246 3 activity activity NN cord-352379-q5inrxcm 246 4 is be VBZ cord-352379-q5inrxcm 246 5 essential essential JJ cord-352379-q5inrxcm 246 6 for for IN cord-352379-q5inrxcm 246 7 viral viral JJ cord-352379-q5inrxcm 246 8 protein protein NN cord-352379-q5inrxcm 246 9 processing processing NN cord-352379-q5inrxcm 246 10 and and CC cord-352379-q5inrxcm 246 11 RNA RNA NNP cord-352379-q5inrxcm 246 12 replication replication NN cord-352379-q5inrxcm 246 13 ; ; : cord-352379-q5inrxcm 246 14 inhibition inhibition NN cord-352379-q5inrxcm 246 15 of of IN cord-352379-q5inrxcm 246 16 the the DT cord-352379-q5inrxcm 246 17 protease protease NN cord-352379-q5inrxcm 246 18 function function NN cord-352379-q5inrxcm 246 19 shuts shut VBZ cord-352379-q5inrxcm 246 20 off off RP cord-352379-q5inrxcm 246 21 viral viral JJ cord-352379-q5inrxcm 246 22 RNA RNA NNP cord-352379-q5inrxcm 246 23 synthesis synthesis NN cord-352379-q5inrxcm 246 24 instantaneously instantaneously RB cord-352379-q5inrxcm 246 25 [ [ -LRB- cord-352379-q5inrxcm 246 26 69 69 CD cord-352379-q5inrxcm 246 27 ] ] -RRB- cord-352379-q5inrxcm 246 28 . . . cord-352379-q5inrxcm 247 1 Thus thus RB cord-352379-q5inrxcm 247 2 , , , cord-352379-q5inrxcm 247 3 the the DT cord-352379-q5inrxcm 247 4 proteases protease NNS cord-352379-q5inrxcm 247 5 are be VBP cord-352379-q5inrxcm 247 6 potentially potentially RB cord-352379-q5inrxcm 247 7 powerful powerful JJ cord-352379-q5inrxcm 247 8 targets target NNS cord-352379-q5inrxcm 247 9 for for IN cord-352379-q5inrxcm 247 10 antivirals antiviral NNS cord-352379-q5inrxcm 247 11 . . . cord-352379-q5inrxcm 248 1 Furthermore furthermore RB cord-352379-q5inrxcm 248 2 , , , cord-352379-q5inrxcm 248 3 the the DT cord-352379-q5inrxcm 248 4 X x NN cord-352379-q5inrxcm 248 5 - - NN cord-352379-q5inrxcm 248 6 ray ray JJ cord-352379-q5inrxcm 248 7 crystallographic crystallographic JJ cord-352379-q5inrxcm 248 8 structure structure NN cord-352379-q5inrxcm 248 9 for for IN cord-352379-q5inrxcm 248 10 the the DT cord-352379-q5inrxcm 248 11 3CLpro 3clpro CD cord-352379-q5inrxcm 248 12 is be VBZ cord-352379-q5inrxcm 248 13 available available JJ cord-352379-q5inrxcm 248 14 [ [ -LRB- cord-352379-q5inrxcm 248 15 4 4 CD cord-352379-q5inrxcm 248 16 ] ] -RRB- cord-352379-q5inrxcm 248 17 , , , cord-352379-q5inrxcm 248 18 as as IN cord-352379-q5inrxcm 248 19 is be VBZ cord-352379-q5inrxcm 248 20 a a DT cord-352379-q5inrxcm 248 21 computation computation NN cord-352379-q5inrxcm 248 22 model model NN cord-352379-q5inrxcm 248 23 for for IN cord-352379-q5inrxcm 248 24 the the DT cord-352379-q5inrxcm 248 25 SARS SARS NNP cord-352379-q5inrxcm 248 26 virus virus NN cord-352379-q5inrxcm 248 27 3CLpro 3clpro CD cord-352379-q5inrxcm 248 28 [ [ -LRB- cord-352379-q5inrxcm 248 29 5 5 CD cord-352379-q5inrxcm 248 30 ] ] -RRB- cord-352379-q5inrxcm 248 31 . . . cord-352379-q5inrxcm 249 1 These these DT cord-352379-q5inrxcm 250 1 In in IN cord-352379-q5inrxcm 250 2 addition addition NN cord-352379-q5inrxcm 250 3 , , , cord-352379-q5inrxcm 250 4 the the DT cord-352379-q5inrxcm 250 5 processes process NNS cord-352379-q5inrxcm 250 6 of of IN cord-352379-q5inrxcm 250 7 virus virus NN cord-352379-q5inrxcm 250 8 assembly assembly NN cord-352379-q5inrxcm 250 9 , , , cord-352379-q5inrxcm 250 10 which which WDT cord-352379-q5inrxcm 250 11 likely likely RB cord-352379-q5inrxcm 250 12 occurs occur VBZ cord-352379-q5inrxcm 250 13 in in IN cord-352379-q5inrxcm 250 14 the the DT cord-352379-q5inrxcm 250 15 ER ER NNP cord-352379-q5inrxcm 250 16 - - HYPH cord-352379-q5inrxcm 250 17 Golgi Golgi NNP cord-352379-q5inrxcm 250 18 intermediate intermediate JJ cord-352379-q5inrxcm 250 19 compartment compartment NN cord-352379-q5inrxcm 250 20 [ [ -LRB- cord-352379-q5inrxcm 250 21 39 39 CD cord-352379-q5inrxcm 250 22 ] ] -RRB- cord-352379-q5inrxcm 250 23 , , , cord-352379-q5inrxcm 250 24 and and CC cord-352379-q5inrxcm 250 25 virus virus NN cord-352379-q5inrxcm 250 26 exit exit NN cord-352379-q5inrxcm 250 27 , , , cord-352379-q5inrxcm 250 28 which which WDT cord-352379-q5inrxcm 250 29 occurs occur VBZ cord-352379-q5inrxcm 250 30 through through IN cord-352379-q5inrxcm 250 31 the the DT cord-352379-q5inrxcm 250 32 cellular cellular JJ cord-352379-q5inrxcm 250 33 secretory secretory JJ cord-352379-q5inrxcm 250 34 pathway pathway NN cord-352379-q5inrxcm 250 35 , , , cord-352379-q5inrxcm 250 36 are be VBP cord-352379-q5inrxcm 250 37 also also RB cord-352379-q5inrxcm 250 38 potential potential JJ cord-352379-q5inrxcm 250 39 antiviral antiviral JJ cord-352379-q5inrxcm 250 40 targets target NNS cord-352379-q5inrxcm 250 41 . . . cord-352379-q5inrxcm 251 1 It -PRON- PRP cord-352379-q5inrxcm 251 2 has have VBZ cord-352379-q5inrxcm 251 3 been be VBN cord-352379-q5inrxcm 251 4 known know VBN cord-352379-q5inrxcm 251 5 that that IN cord-352379-q5inrxcm 251 6 the the DT cord-352379-q5inrxcm 251 7 E E NNP cord-352379-q5inrxcm 251 8 and and CC cord-352379-q5inrxcm 251 9 M M NNP cord-352379-q5inrxcm 251 10 proteins protein NNS cord-352379-q5inrxcm 251 11 are be VBP cord-352379-q5inrxcm 251 12 the the DT cord-352379-q5inrxcm 251 13 minimum minimum JJ cord-352379-q5inrxcm 251 14 components component NNS cord-352379-q5inrxcm 251 15 for for IN cord-352379-q5inrxcm 251 16 virus virus NN cord-352379-q5inrxcm 251 17 assembly assembly NN cord-352379-q5inrxcm 251 18 , , , cord-352379-q5inrxcm 251 19 forming form VBG cord-352379-q5inrxcm 251 20 VLP VLP NNP cord-352379-q5inrxcm 251 21 in in IN cord-352379-q5inrxcm 251 22 the the DT cord-352379-q5inrxcm 251 23 absence absence NN cord-352379-q5inrxcm 251 24 of of IN cord-352379-q5inrxcm 251 25 other other JJ cord-352379-q5inrxcm 251 26 viral viral JJ cord-352379-q5inrxcm 251 27 proteins protein NNS cord-352379-q5inrxcm 251 28 [ [ -LRB- cord-352379-q5inrxcm 251 29 11 11 CD cord-352379-q5inrxcm 251 30 , , , cord-352379-q5inrxcm 251 31 75 75 CD cord-352379-q5inrxcm 251 32 ] ] -RRB- cord-352379-q5inrxcm 251 33 . . . cord-352379-q5inrxcm 252 1 The the DT cord-352379-q5inrxcm 252 2 cellular cellular JJ cord-352379-q5inrxcm 252 3 machinery machinery NN cord-352379-q5inrxcm 252 4 involved involve VBN cord-352379-q5inrxcm 252 5 in in IN cord-352379-q5inrxcm 252 6 the the DT cord-352379-q5inrxcm 252 7 formation formation NN cord-352379-q5inrxcm 252 8 of of IN cord-352379-q5inrxcm 252 9 virus virus NN cord-352379-q5inrxcm 252 10 particles particle NNS cord-352379-q5inrxcm 252 11 is be VBZ cord-352379-q5inrxcm 252 12 still still RB cord-352379-q5inrxcm 252 13 not not RB cord-352379-q5inrxcm 252 14 clear clear JJ cord-352379-q5inrxcm 252 15 ; ; : cord-352379-q5inrxcm 252 16 it -PRON- PRP cord-352379-q5inrxcm 252 17 is be VBZ cord-352379-q5inrxcm 252 18 a a DT cord-352379-q5inrxcm 252 19 potential potential JJ cord-352379-q5inrxcm 252 20 antiviral antiviral JJ cord-352379-q5inrxcm 252 21 target target NN cord-352379-q5inrxcm 252 22 as as RB cord-352379-q5inrxcm 252 23 well well RB cord-352379-q5inrxcm 252 24 . . . cord-352379-q5inrxcm 253 1 The the DT cord-352379-q5inrxcm 253 2 prospect prospect NN cord-352379-q5inrxcm 253 3 for for IN cord-352379-q5inrxcm 253 4 SARS SARS NNP cord-352379-q5inrxcm 253 5 vaccines vaccine NNS cord-352379-q5inrxcm 253 6 is be VBZ cord-352379-q5inrxcm 253 7 uncertain uncertain JJ cord-352379-q5inrxcm 253 8 . . . cord-352379-q5inrxcm 254 1 Several several JJ cord-352379-q5inrxcm 254 2 potential potential JJ cord-352379-q5inrxcm 254 3 approaches approach NNS cord-352379-q5inrxcm 254 4 are be VBP cord-352379-q5inrxcm 254 5 feasible feasible JJ cord-352379-q5inrxcm 254 6 . . . cord-352379-q5inrxcm 255 1 The the DT cord-352379-q5inrxcm 255 2 killed kill VBN cord-352379-q5inrxcm 255 3 whole whole JJ cord-352379-q5inrxcm 255 4 virus virus NN cord-352379-q5inrxcm 255 5 vaccine vaccine NN cord-352379-q5inrxcm 255 6 is be VBZ cord-352379-q5inrxcm 255 7 attractive attractive JJ cord-352379-q5inrxcm 255 8 because because IN cord-352379-q5inrxcm 255 9 of of IN cord-352379-q5inrxcm 255 10 the the DT cord-352379-q5inrxcm 255 11 availability availability NN cord-352379-q5inrxcm 255 12 of of IN cord-352379-q5inrxcm 255 13 a a DT cord-352379-q5inrxcm 255 14 robust robust JJ cord-352379-q5inrxcm 255 15 cell cell NN cord-352379-q5inrxcm 255 16 culture culture NN cord-352379-q5inrxcm 255 17 system system NN cord-352379-q5inrxcm 255 18 that that WDT cord-352379-q5inrxcm 255 19 yields yield VBZ cord-352379-q5inrxcm 255 20 a a DT cord-352379-q5inrxcm 255 21 large large JJ cord-352379-q5inrxcm 255 22 quantity quantity NN cord-352379-q5inrxcm 255 23 of of IN cord-352379-q5inrxcm 255 24 virus virus NN cord-352379-q5inrxcm 255 25 particles particle NNS cord-352379-q5inrxcm 255 26 . . . cord-352379-q5inrxcm 256 1 Attenuated attenuated JJ cord-352379-q5inrxcm 256 2 virus virus NN cord-352379-q5inrxcm 256 3 vaccines vaccine NNS cord-352379-q5inrxcm 256 4 are be VBP cord-352379-q5inrxcm 256 5 still still RB cord-352379-q5inrxcm 256 6 unattainable unattainable JJ cord-352379-q5inrxcm 256 7 because because IN cord-352379-q5inrxcm 256 8 the the DT cord-352379-q5inrxcm 256 9 parameters parameter NNS cord-352379-q5inrxcm 256 10 for for IN cord-352379-q5inrxcm 256 11 virus virus NN cord-352379-q5inrxcm 256 12 attenuation attenuation NN cord-352379-q5inrxcm 256 13 are be VBP cord-352379-q5inrxcm 256 14 not not RB cord-352379-q5inrxcm 256 15 yet yet RB cord-352379-q5inrxcm 256 16 well well RB cord-352379-q5inrxcm 256 17 defined define VBN cord-352379-q5inrxcm 256 18 . . . cord-352379-q5inrxcm 257 1 Ultimately ultimately RB cord-352379-q5inrxcm 257 2 , , , cord-352379-q5inrxcm 257 3 the the DT cord-352379-q5inrxcm 257 4 attenuation attenuation NN cord-352379-q5inrxcm 257 5 of of IN cord-352379-q5inrxcm 257 6 viral viral JJ cord-352379-q5inrxcm 257 7 virulence virulence NN cord-352379-q5inrxcm 257 8 needs need VBZ cord-352379-q5inrxcm 257 9 to to TO cord-352379-q5inrxcm 257 10 be be VB cord-352379-q5inrxcm 257 11 verified verify VBN cord-352379-q5inrxcm 257 12 preclinically preclinically NN cord-352379-q5inrxcm 257 13 in in IN cord-352379-q5inrxcm 257 14 animal animal NN cord-352379-q5inrxcm 257 15 models model NNS cord-352379-q5inrxcm 257 16 . . . cord-352379-q5inrxcm 258 1 Recombinant recombinant JJ cord-352379-q5inrxcm 258 2 subunit subunit NN cord-352379-q5inrxcm 258 3 vaccines vaccine NNS cord-352379-q5inrxcm 258 4 consisting consist VBG cord-352379-q5inrxcm 258 5 of of IN cord-352379-q5inrxcm 258 6 the the DT cord-352379-q5inrxcm 258 7 spike spike NN cord-352379-q5inrxcm 258 8 protein protein NN cord-352379-q5inrxcm 258 9 alone alone RB cord-352379-q5inrxcm 258 10 or or CC cord-352379-q5inrxcm 258 11 in in IN cord-352379-q5inrxcm 258 12 combination combination NN cord-352379-q5inrxcm 258 13 with with IN cord-352379-q5inrxcm 258 14 other other JJ cord-352379-q5inrxcm 258 15 viral viral JJ cord-352379-q5inrxcm 258 16 proteins protein NNS cord-352379-q5inrxcm 258 17 can can MD cord-352379-q5inrxcm 258 18 be be VB cord-352379-q5inrxcm 258 19 prepared prepare VBN cord-352379-q5inrxcm 258 20 by by IN cord-352379-q5inrxcm 258 21 using use VBG cord-352379-q5inrxcm 258 22 the the DT cord-352379-q5inrxcm 258 23 recombinant recombinant JJ cord-352379-q5inrxcm 258 24 proteins protein NNS cord-352379-q5inrxcm 258 25 themselves -PRON- PRP cord-352379-q5inrxcm 258 26 or or CC cord-352379-q5inrxcm 258 27 delivered deliver VBN cord-352379-q5inrxcm 258 28 by by IN cord-352379-q5inrxcm 258 29 virus virus NN cord-352379-q5inrxcm 258 30 vectors vector NNS cord-352379-q5inrxcm 258 31 or or CC cord-352379-q5inrxcm 258 32 as as IN cord-352379-q5inrxcm 258 33 DNA dna NN cord-352379-q5inrxcm 258 34 plasmids plasmid NNS cord-352379-q5inrxcm 258 35 . . . cord-352379-q5inrxcm 259 1 These these DT cord-352379-q5inrxcm 259 2 approaches approach NNS cord-352379-q5inrxcm 259 3 are be VBP cord-352379-q5inrxcm 259 4 technically technically RB cord-352379-q5inrxcm 259 5 feasible feasible JJ cord-352379-q5inrxcm 259 6 . . . cord-352379-q5inrxcm 260 1 However however RB cord-352379-q5inrxcm 260 2 , , , cord-352379-q5inrxcm 260 3 the the DT cord-352379-q5inrxcm 260 4 timetable timetable NN cord-352379-q5inrxcm 260 5 for for IN cord-352379-q5inrxcm 260 6 the the DT cord-352379-q5inrxcm 260 7 development development NN cord-352379-q5inrxcm 260 8 of of IN cord-352379-q5inrxcm 260 9 any any DT cord-352379-q5inrxcm 260 10 of of IN cord-352379-q5inrxcm 260 11 these these DT cord-352379-q5inrxcm 260 12 vaccines vaccine NNS cord-352379-q5inrxcm 260 13 is be VBZ cord-352379-q5inrxcm 260 14 lengthy lengthy JJ cord-352379-q5inrxcm 260 15 , , , cord-352379-q5inrxcm 260 16 and and CC cord-352379-q5inrxcm 260 17 the the DT cord-352379-q5inrxcm 260 18 potential potential JJ cord-352379-q5inrxcm 260 19 success success NN cord-352379-q5inrxcm 260 20 of of IN cord-352379-q5inrxcm 260 21 vaccine vaccine NN cord-352379-q5inrxcm 260 22 development development NN cord-352379-q5inrxcm 260 23 may may MD cord-352379-q5inrxcm 260 24 be be VB cord-352379-q5inrxcm 260 25 hindered hinder VBN cord-352379-q5inrxcm 260 26 by by IN cord-352379-q5inrxcm 260 27 the the DT cord-352379-q5inrxcm 260 28 lack lack NN cord-352379-q5inrxcm 260 29 of of IN cord-352379-q5inrxcm 260 30 accessibility accessibility NN cord-352379-q5inrxcm 260 31 to to IN cord-352379-q5inrxcm 260 32 animal animal NN cord-352379-q5inrxcm 260 33 models model NNS cord-352379-q5inrxcm 260 34 and and CC cord-352379-q5inrxcm 260 35 a a DT cord-352379-q5inrxcm 260 36 suitable suitable JJ cord-352379-q5inrxcm 260 37 population population NN cord-352379-q5inrxcm 260 38 base base NN cord-352379-q5inrxcm 260 39 for for IN cord-352379-q5inrxcm 260 40 clinical clinical JJ cord-352379-q5inrxcm 260 41 trials trial NNS cord-352379-q5inrxcm 260 42 . . . cord-352379-q5inrxcm 261 1 At at IN cord-352379-q5inrxcm 261 2 the the DT cord-352379-q5inrxcm 261 3 present present JJ cord-352379-q5inrxcm 261 4 time time NN cord-352379-q5inrxcm 261 5 , , , cord-352379-q5inrxcm 261 6 the the DT cord-352379-q5inrxcm 261 7 macaque macaque NN cord-352379-q5inrxcm 261 8 monkey monkey NN cord-352379-q5inrxcm 261 9 is be VBZ cord-352379-q5inrxcm 261 10 an an DT cord-352379-q5inrxcm 261 11 acceptable acceptable JJ cord-352379-q5inrxcm 261 12 animal animal NN cord-352379-q5inrxcm 261 13 model model NN cord-352379-q5inrxcm 261 14 . . . cord-352379-q5inrxcm 262 1 However however RB cord-352379-q5inrxcm 262 2 , , , cord-352379-q5inrxcm 262 3 with with IN cord-352379-q5inrxcm 262 4 the the DT cord-352379-q5inrxcm 262 5 SARS SARS NNP cord-352379-q5inrxcm 262 6 epidemic epidemic NN cord-352379-q5inrxcm 262 7 virtually virtually RB cord-352379-q5inrxcm 262 8 over over RB cord-352379-q5inrxcm 262 9 worldwide worldwide RB cord-352379-q5inrxcm 262 10 , , , cord-352379-q5inrxcm 262 11 it -PRON- PRP cord-352379-q5inrxcm 262 12 will will MD cord-352379-q5inrxcm 262 13 be be VB cord-352379-q5inrxcm 262 14 difficult difficult JJ cord-352379-q5inrxcm 262 15 to to TO cord-352379-q5inrxcm 262 16 test test VB cord-352379-q5inrxcm 262 17 the the DT cord-352379-q5inrxcm 262 18 efficacy efficacy NN cord-352379-q5inrxcm 262 19 of of IN cord-352379-q5inrxcm 262 20 these these DT cord-352379-q5inrxcm 262 21 vaccines vaccine NNS cord-352379-q5inrxcm 262 22 . . . cord-352379-q5inrxcm 263 1 Eventually eventually RB cord-352379-q5inrxcm 263 2 , , , cord-352379-q5inrxcm 263 3 ' ' `` cord-352379-q5inrxcm 263 4 ring ring NN cord-352379-q5inrxcm 263 5 ' ' '' cord-352379-q5inrxcm 263 6 vaccination vaccination NN cord-352379-q5inrxcm 263 7 ( ( -LRB- cord-352379-q5inrxcm 263 8 vaccination vaccination NN cord-352379-q5inrxcm 263 9 of of IN cord-352379-q5inrxcm 263 10 the the DT cord-352379-q5inrxcm 263 11 at at IN cord-352379-q5inrxcm 263 12 - - HYPH cord-352379-q5inrxcm 263 13 risk risk NN cord-352379-q5inrxcm 263 14 populations population NNS cord-352379-q5inrxcm 263 15 around around IN cord-352379-q5inrxcm 263 16 the the DT cord-352379-q5inrxcm 263 17 exposed expose VBN cord-352379-q5inrxcm 263 18 people people NNS cord-352379-q5inrxcm 263 19 ) ) -RRB- cord-352379-q5inrxcm 263 20 may may MD cord-352379-q5inrxcm 263 21 have have VB cord-352379-q5inrxcm 263 22 to to TO cord-352379-q5inrxcm 263 23 be be VB cord-352379-q5inrxcm 263 24 attempted attempt VBN cord-352379-q5inrxcm 263 25 . . . cord-352379-q5inrxcm 264 1 Nevertheless nevertheless RB cord-352379-q5inrxcm 264 2 , , , cord-352379-q5inrxcm 264 3 vaccine vaccine NN cord-352379-q5inrxcm 264 4 development development NN cord-352379-q5inrxcm 264 5 is be VBZ cord-352379-q5inrxcm 264 6 clearly clearly RB cord-352379-q5inrxcm 264 7 a a DT cord-352379-q5inrxcm 264 8 top top JJ cord-352379-q5inrxcm 264 9 priority priority NN cord-352379-q5inrxcm 264 10 , , , cord-352379-q5inrxcm 264 11 as as IN cord-352379-q5inrxcm 264 12 vaccines vaccine NNS cord-352379-q5inrxcm 264 13 are be VBP cord-352379-q5inrxcm 264 14 the the DT cord-352379-q5inrxcm 264 15 main main JJ cord-352379-q5inrxcm 264 16 weapons weapon NNS cord-352379-q5inrxcm 264 17 in in IN cord-352379-q5inrxcm 264 18 the the DT cord-352379-q5inrxcm 264 19 arsenal arsenal NN cord-352379-q5inrxcm 264 20 against against IN cord-352379-q5inrxcm 264 21 future future JJ cord-352379-q5inrxcm 264 22 outbreaks outbreak NNS cord-352379-q5inrxcm 264 23 , , , cord-352379-q5inrxcm 264 24 whether whether IN cord-352379-q5inrxcm 264 25 they -PRON- PRP cord-352379-q5inrxcm 264 26 are be VBP cord-352379-q5inrxcm 264 27 natural natural JJ cord-352379-q5inrxcm 264 28 or or CC cord-352379-q5inrxcm 264 29 man man NN cord-352379-q5inrxcm 264 30 - - HYPH cord-352379-q5inrxcm 264 31 made make VBN cord-352379-q5inrxcm 264 32 ( ( -LRB- cord-352379-q5inrxcm 264 33 i.e. i.e. FW cord-352379-q5inrxcm 264 34 bioterrorism bioterrorism NN cord-352379-q5inrxcm 264 35 ) ) -RRB- cord-352379-q5inrxcm 264 36 in in IN cord-352379-q5inrxcm 264 37 origin origin NN cord-352379-q5inrxcm 264 38 . . . cord-352379-q5inrxcm 265 1 A a DT cord-352379-q5inrxcm 265 2 survey survey NN cord-352379-q5inrxcm 265 3 of of IN cord-352379-q5inrxcm 265 4 the the DT cord-352379-q5inrxcm 265 5 currently currently RB cord-352379-q5inrxcm 265 6 available available JJ cord-352379-q5inrxcm 265 7 animal animal NN cord-352379-q5inrxcm 265 8 coronavirus coronavirus NN cord-352379-q5inrxcm 265 9 vaccines vaccine NNS cord-352379-q5inrxcm 265 10 offers offer VBZ cord-352379-q5inrxcm 265 11 a a DT cord-352379-q5inrxcm 265 12 glimpse glimpse NN cord-352379-q5inrxcm 265 13 of of IN cord-352379-q5inrxcm 265 14 the the DT cord-352379-q5inrxcm 265 15 potential potential JJ cord-352379-q5inrxcm 265 16 efficacy efficacy NN cord-352379-q5inrxcm 265 17 of of IN cord-352379-q5inrxcm 265 18 SARS SARS NNP cord-352379-q5inrxcm 265 19 vaccines vaccine NNS cord-352379-q5inrxcm 265 20 . . . cord-352379-q5inrxcm 266 1 Live live JJ cord-352379-q5inrxcm 266 2 attenuated attenuated JJ cord-352379-q5inrxcm 266 3 vaccines vaccine NNS cord-352379-q5inrxcm 266 4 have have VBP cord-352379-q5inrxcm 266 5 been be VBN cord-352379-q5inrxcm 266 6 used use VBN cord-352379-q5inrxcm 266 7 effectively effectively RB cord-352379-q5inrxcm 266 8 against against IN cord-352379-q5inrxcm 266 9 IBV IBV NNP cord-352379-q5inrxcm 266 10 . . . cord-352379-q5inrxcm 267 1 Sometimes sometimes RB cord-352379-q5inrxcm 267 2 , , , cord-352379-q5inrxcm 267 3 a a DT cord-352379-q5inrxcm 267 4 killed kill VBN cord-352379-q5inrxcm 267 5 virus virus NN cord-352379-q5inrxcm 267 6 vaccine vaccine NN cord-352379-q5inrxcm 267 7 is be VBZ cord-352379-q5inrxcm 267 8 used use VBN cord-352379-q5inrxcm 267 9 as as IN cord-352379-q5inrxcm 267 10 a a DT cord-352379-q5inrxcm 267 11 booster booster NN cord-352379-q5inrxcm 267 12 to to IN cord-352379-q5inrxcm 267 13 the the DT cord-352379-q5inrxcm 267 14 primary primary JJ cord-352379-q5inrxcm 267 15 attenuated attenuated JJ cord-352379-q5inrxcm 267 16 virus virus NN cord-352379-q5inrxcm 267 17 vaccine vaccine NN cord-352379-q5inrxcm 267 18 [ [ -LRB- cord-352379-q5inrxcm 267 19 45 45 CD cord-352379-q5inrxcm 267 20 ] ] -RRB- cord-352379-q5inrxcm 267 21 . . . cord-352379-q5inrxcm 268 1 The the DT cord-352379-q5inrxcm 268 2 drawbacks drawback NNS cord-352379-q5inrxcm 268 3 of of IN cord-352379-q5inrxcm 268 4 these these DT cord-352379-q5inrxcm 268 5 vaccines vaccine NNS cord-352379-q5inrxcm 268 6 are be VBP cord-352379-q5inrxcm 268 7 that that IN cord-352379-q5inrxcm 268 8 IBV IBV NNP cord-352379-q5inrxcm 268 9 exists exist VBZ cord-352379-q5inrxcm 268 10 in in IN cord-352379-q5inrxcm 268 11 multiple multiple JJ cord-352379-q5inrxcm 268 12 antigenic antigenic JJ cord-352379-q5inrxcm 268 13 types type NNS cord-352379-q5inrxcm 268 14 and and CC cord-352379-q5inrxcm 268 15 that that IN cord-352379-q5inrxcm 268 16 the the DT cord-352379-q5inrxcm 268 17 virus virus NN cord-352379-q5inrxcm 268 18 undergoes undergo VBZ cord-352379-q5inrxcm 268 19 t?equent t?equent CD cord-352379-q5inrxcm 268 20 antigenic antigenic JJ cord-352379-q5inrxcm 268 21 changes change NNS cord-352379-q5inrxcm 268 22 as as IN cord-352379-q5inrxcm 268 23 a a DT cord-352379-q5inrxcm 268 24 result result NN cord-352379-q5inrxcm 268 25 of of IN cord-352379-q5inrxcm 268 26 mutations mutation NNS cord-352379-q5inrxcm 268 27 and and CC cord-352379-q5inrxcm 268 28 recombination recombination NN cord-352379-q5inrxcm 268 29 . . . cord-352379-q5inrxcm 269 1 Therefore therefore RB cord-352379-q5inrxcm 269 2 , , , cord-352379-q5inrxcm 269 3 multiple multiple JJ cord-352379-q5inrxcm 269 4 viruses virus NNS cord-352379-q5inrxcm 269 5 of of IN cord-352379-q5inrxcm 269 6 different different JJ cord-352379-q5inrxcm 269 7 serotypes serotype NNS cord-352379-q5inrxcm 269 8 must must MD cord-352379-q5inrxcm 269 9 be be VB cord-352379-q5inrxcm 269 10 used use VBN cord-352379-q5inrxcm 269 11 in in IN cord-352379-q5inrxcm 269 12 combination combination NN cord-352379-q5inrxcm 269 13 vaccines vaccine NNS cord-352379-q5inrxcm 269 14 to to TO cord-352379-q5inrxcm 269 15 protect protect VB cord-352379-q5inrxcm 269 16 against against IN cord-352379-q5inrxcm 269 17 most most JJS cord-352379-q5inrxcm 269 18 IBV IBV NNP cord-352379-q5inrxcm 269 19 serotypes serotype NNS cord-352379-q5inrxcm 269 20 . . . cord-352379-q5inrxcm 270 1 For for IN cord-352379-q5inrxcm 270 2 TGEV TGEV NNP cord-352379-q5inrxcm 270 3 , , , cord-352379-q5inrxcm 270 4 live live JJ cord-352379-q5inrxcm 270 5 attenuated attenuated JJ cord-352379-q5inrxcm 270 6 virus virus NN cord-352379-q5inrxcm 270 7 vaccines vaccine NNS cord-352379-q5inrxcm 270 8 have have VBP cord-352379-q5inrxcm 270 9 been be VBN cord-352379-q5inrxcm 270 10 used use VBN cord-352379-q5inrxcm 270 11 to to TO cord-352379-q5inrxcm 270 12 vaccinate vaccinate VB cord-352379-q5inrxcm 270 13 the the DT cord-352379-q5inrxcm 270 14 adult adult NN cord-352379-q5inrxcm 270 15 pigs pig NNS cord-352379-q5inrxcm 270 16 . . . cord-352379-q5inrxcm 271 1 The the DT cord-352379-q5inrxcm 271 2 vulnerable vulnerable JJ cord-352379-q5inrxcm 271 3 piglets piglet NNS cord-352379-q5inrxcm 271 4 receive receive VBP cord-352379-q5inrxcm 271 5 the the DT cord-352379-q5inrxcm 271 6 protective protective JJ cord-352379-q5inrxcm 271 7 antibodies antibody NNS cord-352379-q5inrxcm 271 8 through through IN cord-352379-q5inrxcm 271 9 milk milk NN cord-352379-q5inrxcm 271 10 . . . cord-352379-q5inrxcm 272 1 Improvement improvement NN cord-352379-q5inrxcm 272 2 in in IN cord-352379-q5inrxcm 272 3 lactogenic lactogenic JJ cord-352379-q5inrxcm 272 4 immunity immunity NN cord-352379-q5inrxcm 272 5 is be VBZ cord-352379-q5inrxcm 272 6 therefore therefore RB cord-352379-q5inrxcm 272 7 the the DT cord-352379-q5inrxcm 272 8 aim aim NN cord-352379-q5inrxcm 272 9 of of IN cord-352379-q5inrxcm 272 10 TGEV TGEV NNP cord-352379-q5inrxcm 272 11 vaccine vaccine NN cord-352379-q5inrxcm 272 12 development development NN cord-352379-q5inrxcm 272 13 . . . cord-352379-q5inrxcm 273 1 Killed kill VBN cord-352379-q5inrxcm 273 2 canine canine JJ cord-352379-q5inrxcm 273 3 coronavirus coronavirus NN cord-352379-q5inrxcm 273 4 has have VBZ cord-352379-q5inrxcm 273 5 proven prove VBN cord-352379-q5inrxcm 273 6 to to TO cord-352379-q5inrxcm 273 7 be be VB cord-352379-q5inrxcm 273 8 efficacious efficacious JJ cord-352379-q5inrxcm 273 9 as as IN cord-352379-q5inrxcm 273 10 a a DT cord-352379-q5inrxcm 273 11 vaccine vaccine NN cord-352379-q5inrxcm 273 12 experimentally experimentally RB cord-352379-q5inrxcm 273 13 [ [ -LRB- cord-352379-q5inrxcm 273 14 64 64 CD cord-352379-q5inrxcm 273 15 ] ] -RRB- cord-352379-q5inrxcm 273 16 , , , cord-352379-q5inrxcm 273 17 although although IN cord-352379-q5inrxcm 273 18 it -PRON- PRP cord-352379-q5inrxcm 273 19 is be VBZ cord-352379-q5inrxcm 273 20 not not RB cord-352379-q5inrxcm 273 21 routinely routinely RB cord-352379-q5inrxcm 273 22 used use VBN cord-352379-q5inrxcm 273 23 because because IN cord-352379-q5inrxcm 273 24 of of IN cord-352379-q5inrxcm 273 25 the the DT cord-352379-q5inrxcm 273 26 lack lack NN cord-352379-q5inrxcm 273 27 of of IN cord-352379-q5inrxcm 273 28 necessity necessity NN cord-352379-q5inrxcm 273 29 . . . cord-352379-q5inrxcm 274 1 On on IN cord-352379-q5inrxcm 274 2 the the DT cord-352379-q5inrxcm 274 3 other other JJ cord-352379-q5inrxcm 274 4 hand hand NN cord-352379-q5inrxcm 274 5 , , , cord-352379-q5inrxcm 274 6 feline feline JJ cord-352379-q5inrxcm 274 7 coronavirus coronavirus NN cord-352379-q5inrxcm 274 8 vaccines vaccine NNS cord-352379-q5inrxcm 274 9 have have VBP cord-352379-q5inrxcm 274 10 been be VBN cord-352379-q5inrxcm 274 11 proven prove VBN cord-352379-q5inrxcm 274 12 to to TO cord-352379-q5inrxcm 274 13 be be VB cord-352379-q5inrxcm 274 14 not not RB cord-352379-q5inrxcm 274 15 only only RB cord-352379-q5inrxcm 274 16 inefficacious inefficacious JJ cord-352379-q5inrxcm 274 17 ; ; : cord-352379-q5inrxcm 274 18 worse worse RBR cord-352379-q5inrxcm 274 19 yet yet RB cord-352379-q5inrxcm 274 20 , , , cord-352379-q5inrxcm 274 21 the the DT cord-352379-q5inrxcm 274 22 ? ? . cord-352379-q5inrxcm 274 23 , , , cord-352379-q5inrxcm 274 24 have have VBP cord-352379-q5inrxcm 274 25 been be VBN cord-352379-q5inrxcm 274 26 shown show VBN cord-352379-q5inrxcm 274 27 to to TO cord-352379-q5inrxcm 274 28 lead lead VB cord-352379-q5inrxcm 274 29 to to IN cord-352379-q5inrxcm 274 30 even even RB cord-352379-q5inrxcm 274 31 more more RBR cord-352379-q5inrxcm 274 32 severe severe JJ cord-352379-q5inrxcm 274 33 viral viral JJ cord-352379-q5inrxcm 274 34 infections infection NNS cord-352379-q5inrxcm 274 35 in in IN cord-352379-q5inrxcm 274 36 the the DT cord-352379-q5inrxcm 274 37 vaccinated vaccinated JJ cord-352379-q5inrxcm 274 38 cats cat NNS cord-352379-q5inrxcm 274 39 [ [ -LRB- cord-352379-q5inrxcm 274 40 78 78 CD cord-352379-q5inrxcm 274 41 ] ] -RRB- cord-352379-q5inrxcm 274 42 . . . cord-352379-q5inrxcm 275 1 Enhancement enhancement NN cord-352379-q5inrxcm 275 2 of of IN cord-352379-q5inrxcm 275 3 viral viral JJ cord-352379-q5inrxcm 275 4 infections infection NNS cord-352379-q5inrxcm 275 5 by by IN cord-352379-q5inrxcm 275 6 vaccines vaccine NNS cord-352379-q5inrxcm 275 7 is be VBZ cord-352379-q5inrxcm 275 8 probably probably RB cord-352379-q5inrxcm 275 9 due due JJ cord-352379-q5inrxcm 275 10 to to IN cord-352379-q5inrxcm 275 11 the the DT cord-352379-q5inrxcm 275 12 phenomenon phenomenon NN cord-352379-q5inrxcm 275 13 of of IN cord-352379-q5inrxcm 275 14 antibody antibody NN cord-352379-q5inrxcm 275 15 - - HYPH cord-352379-q5inrxcm 275 16 dependent dependent JJ cord-352379-q5inrxcm 275 17 enhancement enhancement NN cord-352379-q5inrxcm 275 18 ( ( -LRB- cord-352379-q5inrxcm 275 19 ADE ADE NNP cord-352379-q5inrxcm 275 20 ) ) -RRB- cord-352379-q5inrxcm 275 21 , , , cord-352379-q5inrxcm 275 22 in in IN cord-352379-q5inrxcm 275 23 which which WDT cord-352379-q5inrxcm 275 24 antibodies antibody NNS cord-352379-q5inrxcm 275 25 against against IN cord-352379-q5inrxcm 275 26 certain certain JJ cord-352379-q5inrxcm 275 27 epitopes epitope NNS cord-352379-q5inrxcm 275 28 of of IN cord-352379-q5inrxcm 275 29 the the DT cord-352379-q5inrxcm 275 30 spike spike NN cord-352379-q5inrxcm 275 31 protein protein NN cord-352379-q5inrxcm 275 32 complex complex NN cord-352379-q5inrxcm 275 33 with with IN cord-352379-q5inrxcm 275 34 the the DT cord-352379-q5inrxcm 275 35 virus virus NN cord-352379-q5inrxcm 275 36 particles particle NNS cord-352379-q5inrxcm 275 37 and and CC cord-352379-q5inrxcm 275 38 enhance enhance VB cord-352379-q5inrxcm 275 39 their -PRON- PRP$ cord-352379-q5inrxcm 275 40 infectivity infectivity NN cord-352379-q5inrxcm 275 41 [ [ -LRB- cord-352379-q5inrxcm 275 42 171 171 CD cord-352379-q5inrxcm 275 43 . . . cord-352379-q5inrxcm 276 1 It -PRON- PRP cord-352379-q5inrxcm 276 2 is be VBZ cord-352379-q5inrxcm 276 3 difficult difficult JJ cord-352379-q5inrxcm 276 4 to to TO cord-352379-q5inrxcm 276 5 predict predict VB cord-352379-q5inrxcm 276 6 how how WRB cord-352379-q5inrxcm 276 7 the the DT cord-352379-q5inrxcm 276 8 candidate candidate NN cord-352379-q5inrxcm 276 9 SARS SARS NNP cord-352379-q5inrxcm 276 10 virus virus NN cord-352379-q5inrxcm 276 11 vaccines vaccine NNS cord-352379-q5inrxcm 276 12 will will MD cord-352379-q5inrxcm 276 13 behave behave VB cord-352379-q5inrxcm 276 14 . . . cord-352379-q5inrxcm 277 1 If if IN cord-352379-q5inrxcm 277 2 immune immune JJ cord-352379-q5inrxcm 277 3 response response NN cord-352379-q5inrxcm 277 4 plays play VBZ cord-352379-q5inrxcm 277 5 an an DT cord-352379-q5inrxcm 277 6 important important JJ cord-352379-q5inrxcm 277 7 role role NN cord-352379-q5inrxcm 277 8 in in IN cord-352379-q5inrxcm 277 9 the the DT cord-352379-q5inrxcm 277 10 pathogenesis pathogenesis NN cord-352379-q5inrxcm 277 11 of of IN cord-352379-q5inrxcm 277 12 SARS SARS NNP cord-352379-q5inrxcm 277 13 , , , cord-352379-q5inrxcm 277 14 then then RB cord-352379-q5inrxcm 277 15 an an DT cord-352379-q5inrxcm 277 16 effective effective JJ cord-352379-q5inrxcm 277 17 SARS SARS NNP cord-352379-q5inrxcm 277 18 vaccine vaccine NN cord-352379-q5inrxcm 277 19 may may MD cord-352379-q5inrxcm 277 20 turn turn VB cord-352379-q5inrxcm 277 21 out out RP cord-352379-q5inrxcm 277 22 to to TO cord-352379-q5inrxcm 277 23 be be VB cord-352379-q5inrxcm 277 24 as as RB cord-352379-q5inrxcm 277 25 elusive elusive JJ cord-352379-q5inrxcm 277 26 as as IN cord-352379-q5inrxcm 277 27 the the DT cord-352379-q5inrxcm 277 28 FIPV FIPV NNP cord-352379-q5inrxcm 277 29 vaccines vaccine NNS cord-352379-q5inrxcm 277 30 . . . cord-352379-q5inrxcm 278 1 Similar similar JJ cord-352379-q5inrxcm 278 2 difficulties difficulty NNS cord-352379-q5inrxcm 278 3 have have VBP cord-352379-q5inrxcm 278 4 plagued plague VBN cord-352379-q5inrxcm 278 5 the the DT cord-352379-q5inrxcm 278 6 developments development NNS cord-352379-q5inrxcm 278 7 of of IN cord-352379-q5inrxcm 278 8 other other JJ cord-352379-q5inrxcm 278 9 viral viral JJ cord-352379-q5inrxcm 278 10 vaccines vaccine NNS cord-352379-q5inrxcm 278 11 , , , cord-352379-q5inrxcm 278 12 such such JJ cord-352379-q5inrxcm 278 13 as as IN cord-352379-q5inrxcm 278 14 dengue dengue NN cord-352379-q5inrxcm 278 15 virus virus NN cord-352379-q5inrxcm 278 16 , , , cord-352379-q5inrxcm 278 17 HIV HIV NNP cord-352379-q5inrxcm 278 18 , , , cord-352379-q5inrxcm 278 19 hepatitis hepatitis NN cord-352379-q5inrxcm 278 20 C C NNP cord-352379-q5inrxcm 278 21 virus virus NN cord-352379-q5inrxcm 278 22 . . . cord-352379-q5inrxcm 279 1 SARS SARS NNP cord-352379-q5inrxcm 279 2 is be VBZ cord-352379-q5inrxcm 279 3 the the DT cord-352379-q5inrxcm 279 4 first first JJ cord-352379-q5inrxcm 279 5 newly newly RB cord-352379-q5inrxcm 279 6 emerged emerge VBN cord-352379-q5inrxcm 279 7 infectious infectious JJ cord-352379-q5inrxcm 279 8 disease disease NN cord-352379-q5inrxcm 279 9 in in IN cord-352379-q5inrxcm 279 10 this this DT cord-352379-q5inrxcm 279 11 century century NN cord-352379-q5inrxcm 279 12 . . . cord-352379-q5inrxcm 280 1 It -PRON- PRP cord-352379-q5inrxcm 280 2 is be VBZ cord-352379-q5inrxcm 280 3 not not RB cord-352379-q5inrxcm 280 4 likely likely JJ cord-352379-q5inrxcm 280 5 to to TO cord-352379-q5inrxcm 280 6 be be VB cord-352379-q5inrxcm 280 7 the the DT cord-352379-q5inrxcm 280 8 last last JJ cord-352379-q5inrxcm 280 9 one one NN cord-352379-q5inrxcm 280 10 . . . cord-352379-q5inrxcm 281 1 Even even RB cord-352379-q5inrxcm 281 2 though though IN cord-352379-q5inrxcm 281 3 the the DT cord-352379-q5inrxcm 281 4 SARS SARS NNP cord-352379-q5inrxcm 281 5 outbreak outbreak NN cord-352379-q5inrxcm 281 6 is be VBZ cord-352379-q5inrxcm 281 7 now now RB cord-352379-q5inrxcm 281 8 under under IN cord-352379-q5inrxcm 281 9 control control NN cord-352379-q5inrxcm 281 10 after after IN cord-352379-q5inrxcm 281 11 a a DT cord-352379-q5inrxcm 281 12 devastating devastating JJ cord-352379-q5inrxcm 281 13 run run NN cord-352379-q5inrxcm 281 14 of of IN cord-352379-q5inrxcm 281 15 more more JJR cord-352379-q5inrxcm 281 16 than than IN cord-352379-q5inrxcm 281 17 6 6 CD cord-352379-q5inrxcm 281 18 months month NNS cord-352379-q5inrxcm 281 19 that that WDT cord-352379-q5inrxcm 281 20 affected affect VBD cord-352379-q5inrxcm 281 21 and and CC cord-352379-q5inrxcm 281 22 threatened threaten VBD cord-352379-q5inrxcm 281 23 many many JJ cord-352379-q5inrxcm 281 24 countries country NNS cord-352379-q5inrxcm 281 25 worldwide worldwide RB cord-352379-q5inrxcm 281 26 , , , cord-352379-q5inrxcm 281 27 the the DT cord-352379-q5inrxcm 281 28 virus virus NN cord-352379-q5inrxcm 281 29 will will MD cord-352379-q5inrxcm 281 30 continue continue VB cord-352379-q5inrxcm 281 31 to to TO cord-352379-q5inrxcm 281 32 pose pose VB cord-352379-q5inrxcm 281 33 a a DT cord-352379-q5inrxcm 281 34 threat threat NN cord-352379-q5inrxcm 281 35 in in IN cord-352379-q5inrxcm 281 36 the the DT cord-352379-q5inrxcm 281 37 near near JJ cord-352379-q5inrxcm 281 38 future future NN cord-352379-q5inrxcm 281 39 . . . cord-352379-q5inrxcm 282 1 Because because IN cord-352379-q5inrxcm 282 2 of of IN cord-352379-q5inrxcm 282 3 possible possible JJ cord-352379-q5inrxcm 282 4 human human JJ cord-352379-q5inrxcm 282 5 and and CC cord-352379-q5inrxcm 282 6 animal animal NN cord-352379-q5inrxcm 282 7 reservoirs reservoir NNS cord-352379-q5inrxcm 282 8 for for IN cord-352379-q5inrxcm 282 9 the the DT cord-352379-q5inrxcm 282 10 virus virus NN cord-352379-q5inrxcm 282 11 , , , cord-352379-q5inrxcm 282 12 SARS SARS NNP cord-352379-q5inrxcm 282 13 may may MD cord-352379-q5inrxcm 282 14 return return VB cord-352379-q5inrxcm 282 15 in in IN cord-352379-q5inrxcm 282 16 the the DT cord-352379-q5inrxcm 282 17 coming coming JJ cord-352379-q5inrxcm 282 18 months month NNS cord-352379-q5inrxcm 282 19 or or CC cord-352379-q5inrxcm 282 20 years year NNS cord-352379-q5inrxcm 282 21 . . . cord-352379-q5inrxcm 283 1 In in IN cord-352379-q5inrxcm 283 2 the the DT cord-352379-q5inrxcm 283 3 short short JJ cord-352379-q5inrxcm 283 4 term term NN cord-352379-q5inrxcm 283 5 , , , cord-352379-q5inrxcm 283 6 the the DT cord-352379-q5inrxcm 283 7 isolation isolation NN cord-352379-q5inrxcm 283 8 and and CC cord-352379-q5inrxcm 283 9 quarantine quarantine NN cord-352379-q5inrxcm 283 10 of of IN cord-352379-q5inrxcm 283 11 patients patient NNS cord-352379-q5inrxcm 283 12 and and CC cord-352379-q5inrxcm 283 13 exposed expose VBN cord-352379-q5inrxcm 283 14 individuals individual NNS cord-352379-q5inrxcm 283 15 remain remain VBP cord-352379-q5inrxcm 283 16 the the DT cord-352379-q5inrxcm 283 17 only only JJ cord-352379-q5inrxcm 283 18 effective effective JJ cord-352379-q5inrxcm 283 19 means mean NNS cord-352379-q5inrxcm 283 20 of of IN cord-352379-q5inrxcm 283 21 containing contain VBG cord-352379-q5inrxcm 283 22 an an DT cord-352379-q5inrxcm 283 23 outbreak outbreak NN cord-352379-q5inrxcm 283 24 . . . cord-352379-q5inrxcm 284 1 Valuable valuable JJ cord-352379-q5inrxcm 284 2 experience experience NN cord-352379-q5inrxcm 284 3 in in IN cord-352379-q5inrxcm 284 4 disease disease NN cord-352379-q5inrxcm 284 5 control control NN cord-352379-q5inrxcm 284 6 was be VBD cord-352379-q5inrxcm 284 7 gained gain VBN cord-352379-q5inrxcm 284 8 from from IN cord-352379-q5inrxcm 284 9 this this DT cord-352379-q5inrxcm 284 10 first first JJ cord-352379-q5inrxcm 284 11 outbreak outbreak NN cord-352379-q5inrxcm 284 12 ; ; : cord-352379-q5inrxcm 284 13 thus thus RB cord-352379-q5inrxcm 284 14 , , , cord-352379-q5inrxcm 284 15 the the DT cord-352379-q5inrxcm 284 16 future future JJ cord-352379-q5inrxcm 284 17 outbreaks outbreak NNS cord-352379-q5inrxcm 284 18 of of IN cord-352379-q5inrxcm 284 19 SARS SARS NNP cord-352379-q5inrxcm 284 20 and and CC cord-352379-q5inrxcm 284 21 other other JJ cord-352379-q5inrxcm 284 22 emerging emerge VBG cord-352379-q5inrxcm 284 23 and and CC cord-352379-q5inrxcm 284 24 re re JJ cord-352379-q5inrxcm 284 25 - - JJ cord-352379-q5inrxcm 284 26 emerging emerge VBG cord-352379-q5inrxcm 284 27 respiratory respiratory JJ cord-352379-q5inrxcm 284 28 infectious infectious JJ cord-352379-q5inrxcm 284 29 diseases disease NNS cord-352379-q5inrxcm 284 30 will will MD cord-352379-q5inrxcm 284 31 likely likely RB cord-352379-q5inrxcm 284 32 be be VB cord-352379-q5inrxcm 284 33 limited limit VBN cord-352379-q5inrxcm 284 34 to to IN cord-352379-q5inrxcm 284 35 sporadic sporadic JJ cord-352379-q5inrxcm 284 36 occurrences occurrence NNS cord-352379-q5inrxcm 284 37 . . . cord-352379-q5inrxcm 285 1 Hopefully hopefully RB cord-352379-q5inrxcm 285 2 , , , cord-352379-q5inrxcm 285 3 intensive intensive JJ cord-352379-q5inrxcm 285 4 studies study NNS cord-352379-q5inrxcm 285 5 of of IN cord-352379-q5inrxcm 285 6 the the DT cord-352379-q5inrxcm 285 7 SARS SARS NNP cord-352379-q5inrxcm 285 8 virus virus NN cord-352379-q5inrxcm 285 9 in in IN cord-352379-q5inrxcm 285 10 the the DT cord-352379-q5inrxcm 285 11 near near JJ cord-352379-q5inrxcm 285 12 future future NN cord-352379-q5inrxcm 285 13 will will MD cord-352379-q5inrxcm 285 14 provide provide VB cord-352379-q5inrxcm 285 15 sufficient sufficient JJ cord-352379-q5inrxcm 285 16 understanding understanding NN cord-352379-q5inrxcm 285 17 of of IN cord-352379-q5inrxcm 285 18 its -PRON- PRP$ cord-352379-q5inrxcm 285 19 molecular molecular JJ cord-352379-q5inrxcm 285 20 biology biology NN cord-352379-q5inrxcm 285 21 and and CC cord-352379-q5inrxcm 285 22 mechanism mechanism NN cord-352379-q5inrxcm 285 23 of of IN cord-352379-q5inrxcm 285 24 pathogenesis pathogenesis NN cord-352379-q5inrxcm 285 25 to to TO cord-352379-q5inrxcm 285 26 enable enable VB cord-352379-q5inrxcm 285 27 the the DT cord-352379-q5inrxcm 285 28 development development NN cord-352379-q5inrxcm 285 29 of of IN cord-352379-q5inrxcm 285 30 antiviral antiviral JJ cord-352379-q5inrxcm 285 31 drugs drug NNS cord-352379-q5inrxcm 285 32 and and CC cord-352379-q5inrxcm 285 33 vaccines vaccine NNS cord-352379-q5inrxcm 285 34 . . . cord-352379-q5inrxcm 286 1 Only only RB cord-352379-q5inrxcm 286 2 then then RB cord-352379-q5inrxcm 286 3 can can MD cord-352379-q5inrxcm 286 4 we -PRON- PRP cord-352379-q5inrxcm 286 5 effectively effectively RB cord-352379-q5inrxcm 286 6 control control VB cord-352379-q5inrxcm 286 7 the the DT cord-352379-q5inrxcm 286 8 disease disease NN cord-352379-q5inrxcm 286 9 . . . cord-352379-q5inrxcm 286 10 _SP cord-352379-q5inrxcm 287 1 Pet pet NN cord-352379-q5inrxcm 287 2 theory theory NN cord-352379-q5inrxcm 287 3 comes come VBZ cord-352379-q5inrxcm 287 4 to to IN cord-352379-q5inrxcm 287 5 the the DT cord-352379-q5inrxcm 287 6 fore fore NN cord-352379-q5inrxcm 287 7 in in IN cord-352379-q5inrxcm 287 8 fight fight NN cord-352379-q5inrxcm 287 9 against against IN cord-352379-q5inrxcm 287 10 SARS SARS NNP cord-352379-q5inrxcm 287 11 Engineering Engineering NNP cord-352379-q5inrxcm 287 12 the the DT cord-352379-q5inrxcm 287 13 largest large JJS cord-352379-q5inrxcm 287 14 RNA RNA NNP cord-352379-q5inrxcm 287 15 virus virus NN cord-352379-q5inrxcm 287 16 genome genome NN cord-352379-q5inrxcm 287 17 as as IN cord-352379-q5inrxcm 287 18 an an DT cord-352379-q5inrxcm 287 19 infectious infectious JJ cord-352379-q5inrxcm 287 20 bacteria1 bacteria1 NN cord-352379-q5inrxcm 287 21 artificial artificial JJ cord-352379-q5inrxcm 287 22 chromosome chromosome NN cord-352379-q5inrxcm 287 23 Induction Induction NNP cord-352379-q5inrxcm 287 24 of of IN cord-352379-q5inrxcm 287 25 apoptosis apoptosis NN cord-352379-q5inrxcm 287 26 in in IN cord-352379-q5inrxcm 287 27 murine murine JJ cord-352379-q5inrxcm 287 28 coronavims coronavim NNS cord-352379-q5inrxcm 287 29 - - HYPH cord-352379-q5inrxcm 287 30 infected infect VBN cord-352379-q5inrxcm 287 31 cultured cultured JJ cord-352379-q5inrxcm 287 32 cells cell NNS cord-352379-q5inrxcm 287 33 and and CC cord-352379-q5inrxcm 287 34 demonstration demonstration NN cord-352379-q5inrxcm 287 35 of of IN cord-352379-q5inrxcm 287 36 E e NN cord-352379-q5inrxcm 287 37 protein protein NN cord-352379-q5inrxcm 287 38 as as IN cord-352379-q5inrxcm 288 1 an an DT cord-352379-q5inrxcm 288 2 apoptosis apoptosis NN cord-352379-q5inrxcm 288 3 inducer inducer NN cord-352379-q5inrxcm 288 4 Structure structure NN cord-352379-q5inrxcm 288 5 of of IN cord-352379-q5inrxcm 288 6 coronavirus coronavirus NN cord-352379-q5inrxcm 288 7 main main JJ cord-352379-q5inrxcm 288 8 proteinase proteinase NN cord-352379-q5inrxcm 288 9 reveals reveal VBZ cord-352379-q5inrxcm 288 10 combination combination NN cord-352379-q5inrxcm 288 11 of of IN cord-352379-q5inrxcm 288 12 a a DT cord-352379-q5inrxcm 288 13 chymotrypsin chymotrypsin NN cord-352379-q5inrxcm 288 14 fold fold JJ cord-352379-q5inrxcm 288 15 with with IN cord-352379-q5inrxcm 288 16 an an DT cord-352379-q5inrxcm 288 17 extra extra JJ cord-352379-q5inrxcm 288 18 alpha alpha JJ cord-352379-q5inrxcm 288 19 - - HYPH cord-352379-q5inrxcm 288 20 helical helical JJ cord-352379-q5inrxcm 288 21 domain domain NN cord-352379-q5inrxcm 288 22 Coronavirus Coronavirus NNP cord-352379-q5inrxcm 288 23 main main JJ cord-352379-q5inrxcm 288 24 proteinase proteinase NN cord-352379-q5inrxcm 288 25 ( ( -LRB- cord-352379-q5inrxcm 288 26 3CLpro 3clpro CD cord-352379-q5inrxcm 288 27 ) ) -RRB- cord-352379-q5inrxcm 288 28 structure structure NN cord-352379-q5inrxcm 288 29 : : : cord-352379-q5inrxcm 288 30 basis basis NN cord-352379-q5inrxcm 288 31 for for IN cord-352379-q5inrxcm 288 32 design design NN cord-352379-q5inrxcm 288 33 of of IN cord-352379-q5inrxcm 288 34 anti anti JJ cord-352379-q5inrxcm 288 35 - - JJ cord-352379-q5inrxcm 288 36 SARS SARS NNP cord-352379-q5inrxcm 288 37 drugs drug NNS cord-352379-q5inrxcm 288 38 Identification Identification NNP cord-352379-q5inrxcm 288 39 of of IN cord-352379-q5inrxcm 288 40 the the DT cord-352379-q5inrxcm 288 41 catalytic catalytic JJ cord-352379-q5inrxcm 288 42 sites site NNS cord-352379-q5inrxcm 288 43 of of IN cord-352379-q5inrxcm 288 44 a a DT cord-352379-q5inrxcm 288 45 papaln papaln NN cord-352379-q5inrxcm 288 46 - - HYPH cord-352379-q5inrxcm 288 47 like like JJ cord-352379-q5inrxcm 288 48 cystein cystein NNP cord-352379-q5inrxcm 288 49 proteinase proteinase NN cord-352379-q5inrxcm 288 50 of of IN cord-352379-q5inrxcm 288 51 murine murine JJ cord-352379-q5inrxcm 288 52 coronavirus coronavirus NN cord-352379-q5inrxcm 289 1 Two two CD cord-352379-q5inrxcm 289 2 amino amino NN cord-352379-q5inrxcm 289 3 acid acid NN cord-352379-q5inrxcm 289 4 changes change NNS cord-352379-q5inrxcm 289 5 at at IN cord-352379-q5inrxcm 289 6 the the DT cord-352379-q5inrxcm 289 7 N n CD cord-352379-q5inrxcm 289 8 - - HYPH cord-352379-q5inrxcm 289 9 terminus terminus NN cord-352379-q5inrxcm 289 10 of of IN cord-352379-q5inrxcm 289 11 transmissible transmissible JJ cord-352379-q5inrxcm 289 12 gastroenteritis gastroenteritis JJ cord-352379-q5inrxcm 289 13 coronavirus coronavirus NN cord-352379-q5inrxcm 289 14 spike spike NN cord-352379-q5inrxcm 289 15 pro pro NNP cord-352379-q5inrxcm 289 16 . . NNP cord-352379-q5inrxcm 289 17 tein tein NNP cord-352379-q5inrxcm 289 18 result result VBP cord-352379-q5inrxcm 289 19 in in IN cord-352379-q5inrxcm 289 20 the the DT cord-352379-q5inrxcm 289 21 loss loss NN cord-352379-q5inrxcm 289 22 of of IN cord-352379-q5inrxcm 289 23 enteric enteric JJ cord-352379-q5inrxcm 289 24 tropism tropism NN cord-352379-q5inrxcm 289 25 Establishing establish VBG cord-352379-q5inrxcm 289 26 a a DT cord-352379-q5inrxcm 289 27 genetic genetic JJ cord-352379-q5inrxcm 289 28 recombination recombination NN cord-352379-q5inrxcm 289 29 map map NN cord-352379-q5inrxcm 289 30 for for IN cord-352379-q5inrxcm 289 31 murine murine JJ cord-352379-q5inrxcm 289 32 coronavirus coronavirus NN cord-352379-q5inrxcm 289 33 strain strain NN cord-352379-q5inrxcm 289 34 A59 A59 NNP cord-352379-q5inrxcm 289 35 comptementation comptementation NN cord-352379-q5inrxcm 289 36 groups group NNS cord-352379-q5inrxcm 290 1 Persistent persistent JJ cord-352379-q5inrxcm 290 2 infection infection NN cord-352379-q5inrxcm 290 3 promotes promote VBZ cord-352379-q5inrxcm 290 4 crossspecies crossspecie NNS cord-352379-q5inrxcm 290 5 transmissibility transmissibility NN cord-352379-q5inrxcm 290 6 of of IN cord-352379-q5inrxcm 290 7 mouse mouse NNP cord-352379-q5inrxcm 290 8 hepatitis hepatitis NNP cord-352379-q5inrxcm 290 9 virus virus NN cord-352379-q5inrxcm 291 1 Episodic episodic JJ cord-352379-q5inrxcm 291 2 evolution evolution NN cord-352379-q5inrxcm 291 3 mediates mediate VBZ cord-352379-q5inrxcm 291 4 interspecies interspecie NNS cord-352379-q5inrxcm 291 5 transfer transfer NN cord-352379-q5inrxcm 291 6 of of IN cord-352379-q5inrxcm 291 7 a a DT cord-352379-q5inrxcm 291 8 murine murine JJ cord-352379-q5inrxcm 291 9 coronavirus coronavirus NN cord-352379-q5inrxcm 292 1 The the DT cord-352379-q5inrxcm 292 2 production production NN cord-352379-q5inrxcm 292 3 of of IN cord-352379-q5inrxcm 292 4 recombinant recombinant JJ cord-352379-q5inrxcm 292 5 infectious infectious JJ cord-352379-q5inrxcm 292 6 DI di NN cord-352379-q5inrxcm 292 7 - - HYPH cord-352379-q5inrxcm 292 8 particles particle NNS cord-352379-q5inrxcm 292 9 of of IN cord-352379-q5inrxcm 292 10 a a DT cord-352379-q5inrxcm 292 11 murine murine JJ cord-352379-q5inrxcm 292 12 coronavirus coronavirus NN cord-352379-q5inrxcm 292 13 in in IN cord-352379-q5inrxcm 292 14 the the DT cord-352379-q5inrxcm 292 15 absence absence NN cord-352379-q5inrxcm 292 16 of of IN cord-352379-q5inrxcm 292 17 helper helper NN cord-352379-q5inrxcm 292 18 virus virus NN cord-352379-q5inrxcm 293 1 An an DT cord-352379-q5inrxcm 293 2 efficient efficient JJ cord-352379-q5inrxcm 293 3 ribosomal ribosomal JJ cord-352379-q5inrxcm 293 4 frame frame NN cord-352379-q5inrxcm 293 5 - - HYPH cord-352379-q5inrxcm 293 6 shifting shift VBG cord-352379-q5inrxcm 293 7 signal signal NN cord-352379-q5inrxcm 293 8 in in IN cord-352379-q5inrxcm 293 9 the the DT cord-352379-q5inrxcm 293 10 polymerase polymerase NN cord-352379-q5inrxcm 293 11 - - HYPH cord-352379-q5inrxcm 293 12 encoding encode VBG cord-352379-q5inrxcm 293 13 region region NN cord-352379-q5inrxcm 293 14 of of IN cord-352379-q5inrxcm 293 15 the the DT cord-352379-q5inrxcm 293 16 coronavirus coronavirus NN cord-352379-q5inrxcm 294 1 IBV IBV NNP cord-352379-q5inrxcm 294 2 Two two CD cord-352379-q5inrxcm 294 3 coronaviruses coronaviruse NNS cord-352379-q5inrxcm 294 4 isolated isolate VBN cord-352379-q5inrxcm 294 5 from from IN cord-352379-q5inrxcm 294 6 central central JJ cord-352379-q5inrxcm 294 7 nervous nervous JJ cord-352379-q5inrxcm 294 8 system system NN cord-352379-q5inrxcm 294 9 tissue tissue NN cord-352379-q5inrxcm 294 10 of of IN cord-352379-q5inrxcm 294 11 two two CD cord-352379-q5inrxcm 294 12 multiple multiple JJ cord-352379-q5inrxcm 294 13 sclerosis sclerosis NN cord-352379-q5inrxcm 294 14 patients patient NNS cord-352379-q5inrxcm 294 15 Reverse reverse VB cord-352379-q5inrxcm 294 16 genetics genetics NN cord-352379-q5inrxcm 294 17 system system NN cord-352379-q5inrxcm 294 18 for for IN cord-352379-q5inrxcm 294 19 the the DT cord-352379-q5inrxcm 294 20 avian avian JJ cord-352379-q5inrxcm 294 21 coronavirus coronavirus NN cord-352379-q5inrxcm 294 22 infectious infectious JJ cord-352379-q5inrxcm 294 23 bronchitis bronchitis NN cord-352379-q5inrxcm 294 24 virus virus NN cord-352379-q5inrxcm 294 25 Induction Induction NNP cord-352379-q5inrxcm 294 26 of of IN cord-352379-q5inrxcm 294 27 alpha alpha NN cord-352379-q5inrxcm 294 28 interferon interferon NN cord-352379-q5inrxcm 294 29 by by IN cord-352379-q5inrxcm 294 30 transmissible transmissible JJ cord-352379-q5inrxcm 294 31 gastroenteritis gastroenteritis JJ cord-352379-q5inrxcm 294 32 coronavirus coronavirus NN cord-352379-q5inrxcm 294 33 : : : cord-352379-q5inrxcm 294 34 role role NN cord-352379-q5inrxcm 294 35 of of IN cord-352379-q5inrxcm 294 36 transmembrane transmembrane NN cord-352379-q5inrxcm 294 37 glycoprotein glycoprotein NN cord-352379-q5inrxcm 294 38 El El NNP cord-352379-q5inrxcm 294 39 Nucleotide Nucleotide NNP cord-352379-q5inrxcm 294 40 and and CC cord-352379-q5inrxcm 294 41 predicted predict VBD cord-352379-q5inrxcm 294 42 amino amino NN cord-352379-q5inrxcm 294 43 acid acid NN cord-352379-q5inrxcm 294 44 sequences sequence NNS cord-352379-q5inrxcm 294 45 of of IN cord-352379-q5inrxcm 294 46 all all DT cord-352379-q5inrxcm 294 47 genes gene NNS cord-352379-q5inrxcm 294 48 encoded encode VBN cord-352379-q5inrxcm 294 49 by by IN cord-352379-q5inrxcm 294 50 the the DT cord-352379-q5inrxcm 294 51 3 3 CD cord-352379-q5inrxcm 294 52 ' ' `` cord-352379-q5inrxcm 294 53 genomic genomic JJ cord-352379-q5inrxcm 294 54 protion protion NN cord-352379-q5inrxcm 294 55 ( ( -LRB- cord-352379-q5inrxcm 294 56 95 95 CD cord-352379-q5inrxcm 294 57 kb kb NNP cord-352379-q5inrxcm 294 58 ) ) -RRB- cord-352379-q5inrxcm 294 59 of of IN cord-352379-q5inrxcm 294 60 respiratory respiratory JJ cord-352379-q5inrxcm 294 61 bovine bovine JJ cord-352379-q5inrxcm 294 62 coronaviruses coronaviruse NNS cord-352379-q5inrxcm 294 63 and and CC cord-352379-q5inrxcm 294 64 comparisons comparison NNS cord-352379-q5inrxcm 294 65 among among IN cord-352379-q5inrxcm 294 66 respiratory respiratory JJ cord-352379-q5inrxcm 294 67 and and CC cord-352379-q5inrxcm 294 68 enteric enteric JJ cord-352379-q5inrxcm 294 69 coronaviruses coronaviruse NNS cord-352379-q5inrxcm 294 70 Monoclonal Monoclonal NNP cord-352379-q5inrxcm 294 71 antibody antibody NN cord-352379-q5inrxcm 294 72 analysis analysis NN cord-352379-q5inrxcm 294 73 of of IN cord-352379-q5inrxcm 294 74 neutralization neutralization NN cord-352379-q5inrxcm 294 75 and and CC cord-352379-q5inrxcm 294 76 antibody antibody NN cord-352379-q5inrxcm 294 77 - - HYPH cord-352379-q5inrxcm 294 78 dependent dependent JJ cord-352379-q5inrxcm 294 79 enhancement enhancement NN cord-352379-q5inrxcm 294 80 of of IN cord-352379-q5inrxcm 294 81 feline feline JJ cord-352379-q5inrxcm 294 82 infectious infectious JJ cord-352379-q5inrxcm 294 83 peritonitis peritonitis NN cord-352379-q5inrxcm 294 84 virus virus NN cord-352379-q5inrxcm 294 85 Stably stably RB cord-352379-q5inrxcm 294 86 expressed express VBD cord-352379-q5inrxcm 294 87 FIPV FIPV NNP cord-352379-q5inrxcm 294 88 peplomer peplomer NNP cord-352379-q5inrxcm 294 89 protein protein NN cord-352379-q5inrxcm 294 90 induces induce VBZ cord-352379-q5inrxcm 294 91 cell cell NN cord-352379-q5inrxcm 294 92 fusion fusion NN cord-352379-q5inrxcm 294 93 and and CC cord-352379-q5inrxcm 294 94 elicits elicit VBZ cord-352379-q5inrxcm 294 95 neutralizing neutralize VBG cord-352379-q5inrxcm 294 96 antibodies antibody NNS cord-352379-q5inrxcm 294 97 in in IN cord-352379-q5inrxcm 294 98 mice mouse NNS cord-352379-q5inrxcm 295 1 The the DT cord-352379-q5inrxcm 295 2 group group NN cord-352379-q5inrxcm 295 3 - - HYPH cord-352379-q5inrxcm 295 4 specific specific JJ cord-352379-q5inrxcm 295 5 murine murine JJ cord-352379-q5inrxcm 295 6 coronavirus coronavirus NN cord-352379-q5inrxcm 295 7 genes gene NNS cord-352379-q5inrxcm 295 8 are be VBP cord-352379-q5inrxcm 295 9 not not RB cord-352379-q5inrxcm 295 10 essential essential JJ cord-352379-q5inrxcm 295 11 , , , cord-352379-q5inrxcm 295 12 but but CC cord-352379-q5inrxcm 295 13 their -PRON- PRP$ cord-352379-q5inrxcm 295 14 deletion deletion NN cord-352379-q5inrxcm 295 15 , , , cord-352379-q5inrxcm 295 16 by by IN cord-352379-q5inrxcm 295 17 reverse reverse JJ cord-352379-q5inrxcm 295 18 genetics genetic NNS cord-352379-q5inrxcm 295 19 , , , cord-352379-q5inrxcm 295 20 is be VBZ cord-352379-q5inrxcm 295 21 attenuating attenuate VBG cord-352379-q5inrxcm 295 22 in in IN cord-352379-q5inrxcm 295 23 the the DT cord-352379-q5inrxcm 295 24 natural natural JJ cord-352379-q5inrxcm 295 25 host host NN cord-352379-q5inrxcm 296 1 Aminopeptidase Aminopeptidase NNP cord-352379-q5inrxcm 296 2 N N NNP cord-352379-q5inrxcm 296 3 is be VBZ cord-352379-q5inrxcm 296 4 a a DT cord-352379-q5inrxcm 296 5 major major JJ cord-352379-q5inrxcm 296 6 receptor receptor NN cord-352379-q5inrxcm 296 7 for for IN cord-352379-q5inrxcm 296 8 the the DT cord-352379-q5inrxcm 296 9 entero entero NNP cord-352379-q5inrxcm 296 10 - - HYPH cord-352379-q5inrxcm 296 11 pathogenic pathogenic JJ cord-352379-q5inrxcm 296 12 coronavirus coronavirus NN cord-352379-q5inrxcm 296 13 TGEV TGEV NNP cord-352379-q5inrxcm 296 14 Monoclonal monoclonal JJ cord-352379-q5inrxcm 296 15 antibodies antibody NNS cord-352379-q5inrxcm 296 16 to to IN cord-352379-q5inrxcm 296 17 bovine bovine JJ cord-352379-q5inrxcm 296 18 coronavirus coronavirus NN cord-352379-q5inrxcm 296 19 : : : cord-352379-q5inrxcm 296 20 Characteristics characteristic NNS cord-352379-q5inrxcm 296 21 and and CC cord-352379-q5inrxcm 296 22 topographical topographical JJ cord-352379-q5inrxcm 296 23 mapping mapping NN cord-352379-q5inrxcm 296 24 of of IN cord-352379-q5inrxcm 296 25 neutralizing neutralize VBG cord-352379-q5inrxcm 296 26 epitopes epitope NNS cord-352379-q5inrxcm 296 27 on on IN cord-352379-q5inrxcm 296 28 the the DT cord-352379-q5inrxcm 296 29 E2 E2 NNP cord-352379-q5inrxcm 296 30 and and CC cord-352379-q5inrxcm 296 31 E3 e3 NN cord-352379-q5inrxcm 296 32 glycoproteins glycoprotein NNS cord-352379-q5inrxcm 296 33 Fulminant Fulminant NNP cord-352379-q5inrxcm 296 34 hepatic hepatic JJ cord-352379-q5inrxcm 296 35 failure failure NN cord-352379-q5inrxcm 296 36 in in IN cord-352379-q5inrxcm 296 37 murine murine NN cord-352379-q5inrxcm 297 1 he -PRON- PRP cord-352379-q5inrxcm 298 1 ~patitis ~patitis JJ cord-352379-q5inrxcm 298 2 virus virus NN cord-352379-q5inrxcm 298 3 strain strain VBP cord-352379-q5inrxcm 298 4 3 3 CD cord-352379-q5inrxcm 298 5 infection infection NN cord-352379-q5inrxcm 298 6 : : : cord-352379-q5inrxcm 298 7 tissue tissue NN cord-352379-q5inrxcm 298 8 - - HYPH cord-352379-q5inrxcm 298 9 specific specific JJ cord-352379-q5inrxcm 298 10 expression expression NN cord-352379-q5inrxcm 298 11 of of IN cord-352379-q5inrxcm 298 12 a a DT cord-352379-q5inrxcm 298 13 novel novel JJ cord-352379-q5inrxcm 298 14 fg fg NNP cord-352379-q5inrxcm 298 15 12 12 CD cord-352379-q5inrxcm 298 16 prothrombinase prothrombinase NNP cord-352379-q5inrxcm 298 17 Quasi Quasi NNP cord-352379-q5inrxcm 298 18 - - HYPH cord-352379-q5inrxcm 298 19 species specie NNS cord-352379-q5inrxcm 298 20 : : : cord-352379-q5inrxcm 298 21 the the DT cord-352379-q5inrxcm 298 22 concept concept NN cord-352379-q5inrxcm 298 23 and and CC cord-352379-q5inrxcm 298 24 the the DT cord-352379-q5inrxcm 298 25 word word NN cord-352379-q5inrxcm 298 26 Molecular Molecular NNP cord-352379-q5inrxcm 298 27 Basis Basis NNP cord-352379-q5inrxcm 298 28 of of IN cord-352379-q5inrxcm 298 29 Virus Virus NNP cord-352379-q5inrxcm 298 30 Evolution Evolution NNP cord-352379-q5inrxcm 298 31 . . . cord-352379-q5inrxcm 299 1 Cambridge Cambridge NNP cord-352379-q5inrxcm 299 2 Identification Identification NNP cord-352379-q5inrxcm 299 3 of of IN cord-352379-q5inrxcm 299 4 a a DT cord-352379-q5inrxcm 299 5 novel novel JJ cord-352379-q5inrxcm 299 6 coronavirus coronavirus NN cord-352379-q5inrxcm 299 7 in in IN cord-352379-q5inrxcm 299 8 patients patient NNS cord-352379-q5inrxcm 299 9 with with IN cord-352379-q5inrxcm 299 10 severe severe JJ cord-352379-q5inrxcm 299 11 acute acute JJ cord-352379-q5inrxcm 299 12 respiratory respiratory JJ cord-352379-q5inrxcm 299 13 syndrome syndrome NN cord-352379-q5inrxcm 299 14 Aetiology aetiology NN cord-352379-q5inrxcm 299 15 : : : cord-352379-q5inrxcm 300 1 Koch Koch NNP cord-352379-q5inrxcm 300 2 's 's POS cord-352379-q5inrxcm 300 3 postulates postulate NNS cord-352379-q5inrxcm 300 4 fulfilled fulfil VBD cord-352379-q5inrxcm 300 5 for for IN cord-352379-q5inrxcm 300 6 SARS SARS NNP cord-352379-q5inrxcm 300 7 virus virus NN cord-352379-q5inrxcm 300 8 Alteration Alteration NNP cord-352379-q5inrxcm 300 9 of of IN cord-352379-q5inrxcm 300 10 the the DT cord-352379-q5inrxcm 300 11 pH pH NNP cord-352379-q5inrxcm 300 12 dependence dependence NN cord-352379-q5inrxcm 300 13 of of IN cord-352379-q5inrxcm 300 14 coronavirusinduced coronavirusinduced JJ cord-352379-q5inrxcm 300 15 cell cell NN cord-352379-q5inrxcm 300 16 fusion fusion NN cord-352379-q5inrxcm 300 17 : : : cord-352379-q5inrxcm 300 18 effect effect NN cord-352379-q5inrxcm 300 19 of of IN cord-352379-q5inrxcm 300 20 mutations mutation NNS cord-352379-q5inrxcm 300 21 in in IN cord-352379-q5inrxcm 300 22 the the DT cord-352379-q5inrxcm 300 23 spike spike NN cord-352379-q5inrxcm 300 24 glycoprotein glycoprotein NN cord-352379-q5inrxcm 300 25 Major major JJ cord-352379-q5inrxcm 300 26 receptor receptor NN cord-352379-q5inrxcm 300 27 - - HYPH cord-352379-q5inrxcm 300 28 binding binding NN cord-352379-q5inrxcm 300 29 and and CC cord-352379-q5inrxcm 300 30 neutralization neutralization NN cord-352379-q5inrxcm 300 31 determinants determinant NNS cord-352379-q5inrxcm 300 32 are be VBP cord-352379-q5inrxcm 300 33 located locate VBN cord-352379-q5inrxcm 300 34 within within IN cord-352379-q5inrxcm 300 35 the the DT cord-352379-q5inrxcm 300 36 same same JJ cord-352379-q5inrxcm 300 37 domain domain NN cord-352379-q5inrxcm 300 38 of of IN cord-352379-q5inrxcm 300 39 the the DT cord-352379-q5inrxcm 300 40 transmissible transmissible JJ cord-352379-q5inrxcm 300 41 gastroenteritis gastroenteritis NN cord-352379-q5inrxcm 300 42 virus virus NN cord-352379-q5inrxcm 300 43 ( ( -LRB- cord-352379-q5inrxcm 300 44 coronavirus coronavirus NN cord-352379-q5inrxcm 300 45 ) ) -RRB- cord-352379-q5inrxcm 300 46 spike spike NN cord-352379-q5inrxcm 300 47 protein protein NN cord-352379-q5inrxcm 300 48 Fusiondefective Fusiondefective NNP cord-352379-q5inrxcm 300 49 mutants mutant NNS cord-352379-q5inrxcm 300 50 of of IN cord-352379-q5inrxcm 300 51 mouse mouse NN cord-352379-q5inrxcm 300 52 hepatitis hepatitis NN cord-352379-q5inrxcm 300 53 virus virus NN cord-352379-q5inrxcm 300 54 A59 A59 NNP cord-352379-q5inrxcm 300 55 contain contain VBP cord-352379-q5inrxcm 300 56 a a DT cord-352379-q5inrxcm 300 57 mutation mutation NN cord-352379-q5inrxcm 300 58 in in IN cord-352379-q5inrxcm 300 59 the the DT cord-352379-q5inrxcm 300 60 spike spike NN cord-352379-q5inrxcm 300 61 protein protein NN cord-352379-q5inrxcm 300 62 cleavage cleavage NN cord-352379-q5inrxcm 300 63 signal signal NN cord-352379-q5inrxcm 300 64 Coronavirus Coronavirus NNP cord-352379-q5inrxcm 300 65 genome genome NN cord-352379-q5inrxcm 300 66 : : : cord-352379-q5inrxcm 300 67 prediction prediction NN cord-352379-q5inrxcm 300 68 of of IN cord-352379-q5inrxcm 300 69 putative putative JJ cord-352379-q5inrxcm 300 70 functional functional JJ cord-352379-q5inrxcm 300 71 domains domain NNS cord-352379-q5inrxcm 300 72 in in IN cord-352379-q5inrxcm 300 73 the the DT cord-352379-q5inrxcm 300 74 nonstructural nonstructural JJ cord-352379-q5inrxcm 300 75 polyprotein polyprotein NN cord-352379-q5inrxcm 300 76 by by IN cord-352379-q5inrxcm 301 1 comparative comparative JJ cord-352379-q5inrxcm 301 2 amino amino NN cord-352379-q5inrxcm 301 3 acid acid NN cord-352379-q5inrxcm 301 4 sequence sequence NN cord-352379-q5inrxcm 301 5 analysis analysis NN cord-352379-q5inrxcm 301 6 Isolation isolation NN cord-352379-q5inrxcm 301 7 and and CC cord-352379-q5inrxcm 301 8 characterization characterization NN cord-352379-q5inrxcm 301 9 of of IN cord-352379-q5inrxcm 301 10 viruses virus NNS cord-352379-q5inrxcm 301 11 related relate VBN cord-352379-q5inrxcm 301 12 to to IN cord-352379-q5inrxcm 301 13 the the DT cord-352379-q5inrxcm 301 14 SARS SARS NNP cord-352379-q5inrxcm 301 15 coronavirus coronavirus NN cord-352379-q5inrxcm 301 16 from from IN cord-352379-q5inrxcm 301 17 animals animal NNS cord-352379-q5inrxcm 301 18 in in IN cord-352379-q5inrxcm 301 19 southern southern JJ cord-352379-q5inrxcm 301 20 China China NNP cord-352379-q5inrxcm 301 21 Characterization Characterization NNP cord-352379-q5inrxcm 301 22 of of IN cord-352379-q5inrxcm 301 23 a a DT cord-352379-q5inrxcm 301 24 coronavirus coronavirus NN cord-352379-q5inrxcm 301 25 isolated isolate VBN cord-352379-q5inrxcm 301 26 from from IN cord-352379-q5inrxcm 301 27 a a DT cord-352379-q5inrxcm 301 28 diarrheic diarrheic NN cord-352379-q5inrxcm 301 29 foal foal NN cord-352379-q5inrxcm 301 30 Switching switch VBG cord-352379-q5inrxcm 301 31 species species NN cord-352379-q5inrxcm 301 32 tropism tropism NN cord-352379-q5inrxcm 301 33 : : : cord-352379-q5inrxcm 301 34 an an DT cord-352379-q5inrxcm 301 35 effective effective JJ cord-352379-q5inrxcm 301 36 way way NN cord-352379-q5inrxcm 301 37 to to TO cord-352379-q5inrxcm 301 38 manipulate manipulate VB cord-352379-q5inrxcm 301 39 the the DT cord-352379-q5inrxcm 301 40 feline feline JJ cord-352379-q5inrxcm 301 41 coronavirus coronavirus NN cord-352379-q5inrxcm 301 42 genome genome NN cord-352379-q5inrxcm 301 43 A a DT cord-352379-q5inrxcm 301 44 human human JJ cord-352379-q5inrxcm 301 45 RNA RNA NNP cord-352379-q5inrxcm 301 46 viral viral JJ cord-352379-q5inrxcm 301 47 cysteine cysteine NN cord-352379-q5inrxcm 301 48 proteinase proteinase NN cord-352379-q5inrxcm 301 49 that that WDT cord-352379-q5inrxcm 301 50 depends depend VBZ cord-352379-q5inrxcm 301 51 upon upon IN cord-352379-q5inrxcm 301 52 a a DT cord-352379-q5inrxcm 301 53 unique unique JJ cord-352379-q5inrxcm 301 54 Zn2 zn2 NN cord-352379-q5inrxcm 301 55 + + CC cord-352379-q5inrxcm 301 56 -binding -binde VBG cord-352379-q5inrxcm 301 57 finger finger NN cord-352379-q5inrxcm 301 58 connecting connect VBG cord-352379-q5inrxcm 301 59 the the DT cord-352379-q5inrxcm 301 60 two two CD cord-352379-q5inrxcm 301 61 domains domain NNS cord-352379-q5inrxcm 301 62 ofa ofa NNP cord-352379-q5inrxcm 301 63 papain papain NN cord-352379-q5inrxcm 301 64 - - HYPH cord-352379-q5inrxcm 301 65 like like JJ cord-352379-q5inrxcm 302 1 fold fold VB cord-352379-q5inrxcm 302 2 Persistence persistence NN cord-352379-q5inrxcm 302 3 and and CC cord-352379-q5inrxcm 302 4 evolution evolution NN cord-352379-q5inrxcm 302 5 of of IN cord-352379-q5inrxcm 302 6 feline feline JJ cord-352379-q5inrxcm 302 7 coronavirus coronavirus NN cord-352379-q5inrxcm 302 8 in in IN cord-352379-q5inrxcm 302 9 a a DT cord-352379-q5inrxcm 302 10 closed closed JJ cord-352379-q5inrxcm 302 11 cat cat NN cord-352379-q5inrxcm 302 12 - - HYPH cord-352379-q5inrxcm 302 13 breeding breed VBG cord-352379-q5inrxcm 302 14 colony colony NN cord-352379-q5inrxcm 302 15 Feline feline JJ cord-352379-q5inrxcm 302 16 coronavirus coronavirus NN cord-352379-q5inrxcm 302 17 type type NN cord-352379-q5inrxcm 302 18 II ii CD cord-352379-q5inrxcm 302 19 strains strain VBZ cord-352379-q5inrxcm 302 20 79 79 CD cord-352379-q5inrxcm 302 21 - - HYPH cord-352379-q5inrxcm 302 22 1683 1683 CD cord-352379-q5inrxcm 302 23 and and CC cord-352379-q5inrxcm 302 24 79 79 CD cord-352379-q5inrxcm 302 25 - - SYM cord-352379-q5inrxcm 302 26 1146 1146 CD cord-352379-q5inrxcm 302 27 originate originate VBP cord-352379-q5inrxcm 302 28 from from IN cord-352379-q5inrxcm 302 29 a a DT cord-352379-q5inrxcm 302 30 double double JJ cord-352379-q5inrxcm 302 31 recombination recombination NN cord-352379-q5inrxcm 302 32 between between IN cord-352379-q5inrxcm 302 33 feline feline JJ cord-352379-q5inrxcm 302 34 coronavirus coronavirus NN cord-352379-q5inrxcm 302 35 type type NN cord-352379-q5inrxcm 302 36 I -PRON- PRP cord-352379-q5inrxcm 302 37 and and CC cord-352379-q5inrxcm 302 38 canine canine JJ cord-352379-q5inrxcm 302 39 coronavirus coronavirus NN cord-352379-q5inrxcm 302 40 Sequence sequence NN cord-352379-q5inrxcm 302 41 analysis analysis NN cord-352379-q5inrxcm 302 42 of of IN cord-352379-q5inrxcm 302 43 nucleocapsid nucleocapsid NNP cord-352379-q5inrxcm 302 44 gene gene NN cord-352379-q5inrxcm 302 45 and and CC cord-352379-q5inrxcm 302 46 leader leader NN cord-352379-q5inrxcm 302 47 RNA RNA NNP cord-352379-q5inrxcm 302 48 of of IN cord-352379-q5inrxcm 303 1 human human JJ cord-352379-q5inrxcm 303 2 coronavirus coronavirus NN cord-352379-q5inrxcm 303 3 OC43 OC43 NNP cord-352379-q5inrxcm 303 4 Identification Identification NNP cord-352379-q5inrxcm 303 5 of of IN cord-352379-q5inrxcm 303 6 mouse mouse NN cord-352379-q5inrxcm 303 7 hepatitis hepatitis NNP cord-352379-q5inrxcm 303 8 virus virus NN cord-352379-q5inrxcm 303 9 papain papain NN cord-352379-q5inrxcm 303 10 - - HYPH cord-352379-q5inrxcm 303 11 Iike Iike NNP cord-352379-q5inrxcm 303 12 proteinase proteinase NN cord-352379-q5inrxcm 304 1 2 2 CD cord-352379-q5inrxcm 304 2 activity activity NN cord-352379-q5inrxcm 304 3 SARS SARS NNP cord-352379-q5inrxcm 304 4 Virus virus NN cord-352379-q5inrxcm 304 5 : : : cord-352379-q5inrxcm 305 1 The the DT cord-352379-q5inrxcm 305 2 Beginning beginning NN cord-352379-q5inrxcm 305 3 of of IN cord-352379-q5inrxcm 305 4 the the DT cord-352379-q5inrxcm 305 5 Unraveling unraveling NN cord-352379-q5inrxcm 305 6 of of IN cord-352379-q5inrxcm 305 7 a a DT cord-352379-q5inrxcm 305 8 New New NNP cord-352379-q5inrxcm 305 9 Seroepidemiologic Seroepidemiologic NNP cord-352379-q5inrxcm 305 10 survey survey NN cord-352379-q5inrxcm 305 11 of of IN cord-352379-q5inrxcm 305 12 coronavirus coronavirus NN cord-352379-q5inrxcm 305 13 ( ( -LRB- cord-352379-q5inrxcm 305 14 strain strain NN cord-352379-q5inrxcm 305 15 OC OC NNP cord-352379-q5inrxcm 305 16 43 43 CD cord-352379-q5inrxcm 305 17 ) ) -RRB- cord-352379-q5inrxcm 305 18 related relate VBN cord-352379-q5inrxcm 305 19 infections infection NNS cord-352379-q5inrxcm 305 20 in in IN cord-352379-q5inrxcm 305 21 a a DT cord-352379-q5inrxcm 305 22 children child NNS cord-352379-q5inrxcm 305 23 's 's POS cord-352379-q5inrxcm 305 24 population population NN cord-352379-q5inrxcm 305 25 Coronavirns Coronavirns NNP cord-352379-q5inrxcm 305 26 M M NNP cord-352379-q5inrxcm 305 27 proteins protein NNS cord-352379-q5inrxcm 305 28 accumulate accumulate VBP cord-352379-q5inrxcm 305 29 in in IN cord-352379-q5inrxcm 305 30 the the DT cord-352379-q5inrxcm 305 31 Golgi Golgi NNP cord-352379-q5inrxcm 305 32 complex complex NN cord-352379-q5inrxcm 305 33 beyond beyond IN cord-352379-q5inrxcm 305 34 the the DT cord-352379-q5inrxcm 305 35 site site NN cord-352379-q5inrxcm 305 36 of of IN cord-352379-q5inrxcm 305 37 virion virion NN cord-352379-q5inrxcm 305 38 budding bud VBG cord-352379-q5inrxcm 305 39 Mouse Mouse NNP cord-352379-q5inrxcm 305 40 hepatitis hepatitis NN cord-352379-q5inrxcm 305 41 virus virus NN cord-352379-q5inrxcm 305 42 type type NN cord-352379-q5inrxcm 305 43 4 4 CD cord-352379-q5inrxcm 305 44 ( ( -LRB- cord-352379-q5inrxcm 305 45 JHM JHM NNP cord-352379-q5inrxcm 305 46 strain)-induced strain)-induced NNP cord-352379-q5inrxcm 305 47 fatal fatal JJ cord-352379-q5inrxcm 305 48 central central JJ cord-352379-q5inrxcm 305 49 nervous nervous JJ cord-352379-q5inrxcm 305 50 system system NN cord-352379-q5inrxcm 305 51 disease disease NN cord-352379-q5inrxcm 305 52 . . . cord-352379-q5inrxcm 306 1 I. I. NNP cord-352379-q5inrxcm 306 2 Genetic genetic JJ cord-352379-q5inrxcm 306 3 control control NN cord-352379-q5inrxcm 306 4 and and CC cord-352379-q5inrxcm 306 5 the the DT cord-352379-q5inrxcm 306 6 murine murine JJ cord-352379-q5inrxcm 306 7 neuron neuron NN cord-352379-q5inrxcm 306 8 as as IN cord-352379-q5inrxcm 306 9 the the DT cord-352379-q5inrxcm 306 10 susceptible susceptible JJ cord-352379-q5inrxcm 306 11 site site NN cord-352379-q5inrxcm 306 12 of of IN cord-352379-q5inrxcm 306 13 disease disease NN cord-352379-q5inrxcm 306 14 Anderson Anderson NNP cord-352379-q5inrxcm 306 15 LJ LJ NNP cord-352379-q5inrxcm 306 16 , , , cord-352379-q5inrxcm 306 17 SARS SARS NNP cord-352379-q5inrxcm 306 18 Working Working NNP cord-352379-q5inrxcm 306 19 Group Group NNP cord-352379-q5inrxcm 306 20 . . . cord-352379-q5inrxcm 307 1 A a DT cord-352379-q5inrxcm 307 2 novel novel JJ cord-352379-q5inrxcm 307 3 coronavirus coronavirus NN cord-352379-q5inrxcm 307 4 associated associate VBN cord-352379-q5inrxcm 307 5 with with IN cord-352379-q5inrxcm 307 6 severe severe JJ cord-352379-q5inrxcm 307 7 acute acute JJ cord-352379-q5inrxcm 307 8 respiratory respiratory JJ cord-352379-q5inrxcm 307 9 syndrome syndrome NN cord-352379-q5inrxcm 307 10 Localization localization NN cord-352379-q5inrxcm 307 11 of of IN cord-352379-q5inrxcm 307 12 neutralizing neutralize VBG cord-352379-q5inrxcm 307 13 epitopes epitope NNS cord-352379-q5inrxcm 307 14 and and CC cord-352379-q5inrxcm 307 15 the the DT cord-352379-q5inrxcm 307 16 receptor receptor NN cord-352379-q5inrxcm 307 17 - - HYPH cord-352379-q5inrxcm 307 18 binding bind VBG cord-352379-q5inrxcm 307 19 site site NN cord-352379-q5inrxcm 307 20 within within IN cord-352379-q5inrxcm 307 21 the the DT cord-352379-q5inrxcm 307 22 amino amino NN cord-352379-q5inrxcm 307 23 - - HYPH cord-352379-q5inrxcm 307 24 terminal terminal NN cord-352379-q5inrxcm 307 25 330 330 CD cord-352379-q5inrxcm 307 26 amino amino NN cord-352379-q5inrxcm 307 27 acids acid NNS cord-352379-q5inrxcm 307 28 of of IN cord-352379-q5inrxcm 307 29 the the DT cord-352379-q5inrxcm 307 30 murine murine JJ cord-352379-q5inrxcm 307 31 coronavirus coronavirus NN cord-352379-q5inrxcm 307 32 spike spike NN cord-352379-q5inrxcm 307 33 protein protein NN cord-352379-q5inrxcm 308 1 The the DT cord-352379-q5inrxcm 308 2 small small JJ cord-352379-q5inrxcm 308 3 envelope envelope NN cord-352379-q5inrxcm 308 4 protein protein NN cord-352379-q5inrxcm 308 5 is be VBZ cord-352379-q5inrxcm 308 6 not not RB cord-352379-q5inrxcm 308 7 essential essential JJ cord-352379-q5inrxcm 308 8 for for IN cord-352379-q5inrxcm 308 9 routine routine JJ cord-352379-q5inrxcm 308 10 coronavirus coronavirus NN cord-352379-q5inrxcm 308 11 replication replication NN cord-352379-q5inrxcm 308 12 Sequence sequence NN cord-352379-q5inrxcm 308 13 evidence evidence NN cord-352379-q5inrxcm 308 14 for for IN cord-352379-q5inrxcm 308 15 RNA rna NN cord-352379-q5inrxcm 308 16 recombination recombination NN cord-352379-q5inrxcm 308 17 in in IN cord-352379-q5inrxcm 308 18 field field NN cord-352379-q5inrxcm 308 19 isolates isolate NNS cord-352379-q5inrxcm 308 20 of of IN cord-352379-q5inrxcm 308 21 avian avian JJ cord-352379-q5inrxcm 308 22 coronavirus coronavirus NN cord-352379-q5inrxcm 308 23 infectious infectious JJ cord-352379-q5inrxcm 308 24 bronchitis bronchitis NN cord-352379-q5inrxcm 308 25 virus virus NN cord-352379-q5inrxcm 308 26 Protection Protection NNP cord-352379-q5inrxcm 308 27 of of IN cord-352379-q5inrxcm 308 28 chickens chicken NNS cord-352379-q5inrxcm 308 29 after after IN cord-352379-q5inrxcm 308 30 live live RB cord-352379-q5inrxcm 308 31 and and CC cord-352379-q5inrxcm 308 32 inactivated inactivate VBD cord-352379-q5inrxcm 308 33 virus virus NN cord-352379-q5inrxcm 308 34 vaccination vaccination NN cord-352379-q5inrxcm 308 35 against against IN cord-352379-q5inrxcm 308 36 challenge challenge NN cord-352379-q5inrxcm 308 37 with with IN cord-352379-q5inrxcm 308 38 nephropathologenic nephropathologenic NNP cord-352379-q5inrxcm 308 39 infectious infectious JJ cord-352379-q5inrxcm 308 40 bronchitis bronchitis NN cord-352379-q5inrxcm 308 41 virus virus NN cord-352379-q5inrxcm 308 42 PA PA NNP cord-352379-q5inrxcm 308 43 / / SYM cord-352379-q5inrxcm 308 44 Wolgemuth/98 wolgemuth/98 JJ cord-352379-q5inrxcm 308 45 Genetic genetic JJ cord-352379-q5inrxcm 308 46 recombination recombination NN cord-352379-q5inrxcm 308 47 ill ill NNP cord-352379-q5inrxcm 308 48 RNA RNA NNP cord-352379-q5inrxcm 308 49 viruses virus NNS cord-352379-q5inrxcm 308 50 Recombination Recombination NNP cord-352379-q5inrxcm 308 51 and and CC cord-352379-q5inrxcm 308 52 its -PRON- PRP$ cord-352379-q5inrxcm 308 53 evolutionary evolutionary JJ cord-352379-q5inrxcm 308 54 effects effect NNS cord-352379-q5inrxcm 308 55 on on IN cord-352379-q5inrxcm 308 56 viruses virus NNS cord-352379-q5inrxcm 308 57 with with IN cord-352379-q5inrxcm 308 58 RNA RNA NNP cord-352379-q5inrxcm 308 59 genomes genome NNS cord-352379-q5inrxcm 308 60 Molecular Molecular NNP cord-352379-q5inrxcm 308 61 Basis Basis NNP cord-352379-q5inrxcm 308 62 of of IN cord-352379-q5inrxcm 308 63 Virus Virus NNP cord-352379-q5inrxcm 308 64 Evolution Evolution NNP cord-352379-q5inrxcm 308 65 . . . cord-352379-q5inrxcm 309 1 Cambridge Cambridge NNP cord-352379-q5inrxcm 310 1 The the DT cord-352379-q5inrxcm 310 2 molecular molecular JJ cord-352379-q5inrxcm 310 3 biology biology NN cord-352379-q5inrxcm 310 4 of of IN cord-352379-q5inrxcm 310 5 coronaviruses coronaviruse NNS cord-352379-q5inrxcm 310 6 Coronaviridae Coronaviridae NNP cord-352379-q5inrxcm 310 7 and and CC cord-352379-q5inrxcm 310 8 their -PRON- PRP$ cord-352379-q5inrxcm 310 9 replication replication NN cord-352379-q5inrxcm 310 10 Porcine porcine JJ cord-352379-q5inrxcm 310 11 respiratory respiratory JJ cord-352379-q5inrxcm 310 12 coronavirus coronavirus NN cord-352379-q5inrxcm 310 13 : : : cord-352379-q5inrxcm 310 14 molecular molecular JJ cord-352379-q5inrxcm 310 15 features feature NNS cord-352379-q5inrxcm 310 16 and and CC cord-352379-q5inrxcm 310 17 virus virus NN cord-352379-q5inrxcm 310 18 - - HYPH cord-352379-q5inrxcm 310 19 host host NN cord-352379-q5inrxcm 310 20 interactions interaction NNS cord-352379-q5inrxcm 311 1 Syncytia syncytia NN cord-352379-q5inrxcm 311 2 formation formation NN cord-352379-q5inrxcm 311 3 induced induce VBN cord-352379-q5inrxcm 311 4 by by IN cord-352379-q5inrxcm 311 5 coronavirus coronavirus NN cord-352379-q5inrxcm 311 6 infection infection NN cord-352379-q5inrxcm 311 7 is be VBZ cord-352379-q5inrxcm 311 8 associated associate VBN cord-352379-q5inrxcm 311 9 with with IN cord-352379-q5inrxcm 311 10 fragmentation fragmentation NN cord-352379-q5inrxcm 311 11 and and CC cord-352379-q5inrxcm 311 12 rearrangement rearrangement NN cord-352379-q5inrxcm 311 13 of of IN cord-352379-q5inrxcm 311 14 the the DT cord-352379-q5inrxcm 311 15 Golgi Golgi NNP cord-352379-q5inrxcm 311 16 apparatus apparatus NN cord-352379-q5inrxcm 311 17 Targeted target VBN cord-352379-q5inrxcm 311 18 recombination recombination NN cord-352379-q5inrxcm 311 19 within within IN cord-352379-q5inrxcm 311 20 the the DT cord-352379-q5inrxcm 311 21 spike spike NN cord-352379-q5inrxcm 311 22 gene gene NN cord-352379-q5inrxcm 311 23 of of IN cord-352379-q5inrxcm 311 24 murine murine JJ cord-352379-q5inrxcm 311 25 coronavirus coronavirus NN cord-352379-q5inrxcm 311 26 mouse mouse NN cord-352379-q5inrxcm 311 27 hepatitis hepatitis NN cord-352379-q5inrxcm 311 28 virus virus NN cord-352379-q5inrxcm 311 29 A59 A59 NNP cord-352379-q5inrxcm 311 30 : : : cord-352379-q5inrxcm 311 31 Q Q NNP cord-352379-q5inrxcm 311 32 159 159 CD cord-352379-q5inrxcm 311 33 is be VBZ cord-352379-q5inrxcm 311 34 a a DT cord-352379-q5inrxcm 311 35 determinant determinant NN cord-352379-q5inrxcm 311 36 of of IN cord-352379-q5inrxcm 311 37 hepatotropism hepatotropism NNP cord-352379-q5inrxcm 311 38 Induction Induction NNP cord-352379-q5inrxcm 311 39 of of IN cord-352379-q5inrxcm 311 40 caspasedependent caspasedependent NN cord-352379-q5inrxcm 311 41 apoptosis apoptosis NN cord-352379-q5inrxcm 311 42 in in IN cord-352379-q5inrxcm 311 43 cultured cultured JJ cord-352379-q5inrxcm 311 44 cells cell NNS cord-352379-q5inrxcm 311 45 by by IN cord-352379-q5inrxcm 311 46 the the DT cord-352379-q5inrxcm 311 47 avian avian JJ cord-352379-q5inrxcm 311 48 coronavirus coronavirus NN cord-352379-q5inrxcm 311 49 infectious infectious JJ cord-352379-q5inrxcm 311 50 bronchitis bronchitis NN cord-352379-q5inrxcm 311 51 virus virus NN cord-352379-q5inrxcm 311 52 Scqnence Scqnence NNP cord-352379-q5inrxcm 311 53 of of IN cord-352379-q5inrxcm 311 54 mouse mouse NN cord-352379-q5inrxcm 311 55 hepatitis hepatitis NN cord-352379-q5inrxcm 311 56 virus virus NN cord-352379-q5inrxcm 311 57 A59 A59 NNP cord-352379-q5inrxcm 311 58 mRNA mRNA NNP cord-352379-q5inrxcm 312 1 2 2 LS cord-352379-q5inrxcm 312 2 : : : cord-352379-q5inrxcm 312 3 Indications indication NNS cord-352379-q5inrxcm 312 4 for for IN cord-352379-q5inrxcm 312 5 RNArecombination rnarecombination NN cord-352379-q5inrxcm 312 6 between between IN cord-352379-q5inrxcm 312 7 coronavirus coronavirus NN cord-352379-q5inrxcm 312 8 and and CC cord-352379-q5inrxcm 312 9 influenza influenza NN cord-352379-q5inrxcm 312 10 C c NN cord-352379-q5inrxcm 312 11 virus virus NN cord-352379-q5inrxcm 312 12 MHV MHV NNP cord-352379-q5inrxcm 312 13 infection infection NN cord-352379-q5inrxcm 312 14 of of IN cord-352379-q5inrxcm 312 15 the the DT cord-352379-q5inrxcm 312 16 CNS CNS NNP cord-352379-q5inrxcm 312 17 : : : cord-352379-q5inrxcm 312 18 mechanisms mechanism NNS cord-352379-q5inrxcm 312 19 of of IN cord-352379-q5inrxcm 312 20 immune immune NN cord-352379-q5inrxcm 312 21 - - HYPH cord-352379-q5inrxcm 312 22 mediated mediate VBN cord-352379-q5inrxcm 312 23 control control NN cord-352379-q5inrxcm 313 1 Seroepidemiologic Seroepidemiologic NNP cord-352379-q5inrxcm 313 2 studies study NNS cord-352379-q5inrxcm 313 3 of of IN cord-352379-q5inrxcm 313 4 coronavirus coronavirus NN cord-352379-q5inrxcm 313 5 infection infection NN cord-352379-q5inrxcm 313 6 in in IN cord-352379-q5inrxcm 313 7 adults adult NNS cord-352379-q5inrxcm 313 8 and and CC cord-352379-q5inrxcm 313 9 children child NNS cord-352379-q5inrxcm 313 10 Lung Lung NNP cord-352379-q5inrxcm 313 11 pathology pathology NN cord-352379-q5inrxcm 313 12 of of IN cord-352379-q5inrxcm 313 13 fatal fatal JJ cord-352379-q5inrxcm 313 14 severe severe JJ cord-352379-q5inrxcm 313 15 acute acute JJ cord-352379-q5inrxcm 313 16 respiratory respiratory JJ cord-352379-q5inrxcm 313 17 syndrome syndrome NN cord-352379-q5inrxcm 314 1 The the DT cord-352379-q5inrxcm 314 2 nucleocapsid nucleocapsid NN cord-352379-q5inrxcm 314 3 protein protein NN cord-352379-q5inrxcm 314 4 of of IN cord-352379-q5inrxcm 314 5 murine murine JJ cord-352379-q5inrxcm 314 6 hepatitis hepatitis NN cord-352379-q5inrxcm 314 7 virus virus NN cord-352379-q5inrxcm 314 8 type type NN cord-352379-q5inrxcm 314 9 3 3 CD cord-352379-q5inrxcm 314 10 induces induce VBZ cord-352379-q5inrxcm 314 11 transcription transcription NN cord-352379-q5inrxcm 314 12 of of IN cord-352379-q5inrxcm 314 13 the the DT cord-352379-q5inrxcm 314 14 novel novel JJ cord-352379-q5inrxcm 314 15 fgl2 fgl2 NNP cord-352379-q5inrxcm 314 16 prothrombinase prothrombinase NNP cord-352379-q5inrxcm 314 17 gene gene NN cord-352379-q5inrxcm 314 18 SARS SARS NNP cord-352379-q5inrxcm 314 19 in in IN cord-352379-q5inrxcm 314 20 China China NNP cord-352379-q5inrxcm 314 21 : : : cord-352379-q5inrxcm 314 22 Tracking track VBG cord-352379-q5inrxcm 314 23 the the DT cord-352379-q5inrxcm 314 24 roots root NNS cord-352379-q5inrxcm 314 25 of of IN cord-352379-q5inrxcm 314 26 a a DT cord-352379-q5inrxcm 314 27 killer killer NN cord-352379-q5inrxcm 314 28 Transmissible transmissible JJ cord-352379-q5inrxcm 314 29 gastroenteritis gastroenteritis NN cord-352379-q5inrxcm 314 30 coronavirus coronavirus NN cord-352379-q5inrxcm 314 31 gene gene NN cord-352379-q5inrxcm 314 32 7 7 CD cord-352379-q5inrxcm 314 33 is be VBZ cord-352379-q5inrxcm 314 34 not not RB cord-352379-q5inrxcm 314 35 essential essential JJ cord-352379-q5inrxcm 314 36 but but CC cord-352379-q5inrxcm 314 37 influences influence NNS cord-352379-q5inrxcm 314 38 in in IN cord-352379-q5inrxcm 314 39 vivo vivo NN cord-352379-q5inrxcm 314 40 virus virus NN cord-352379-q5inrxcm 314 41 replication replication NN cord-352379-q5inrxcm 314 42 and and CC cord-352379-q5inrxcm 314 43 virulence virulence NN cord-352379-q5inrxcm 314 44 Coronavirus Coronavirus NNP cord-352379-q5inrxcm 314 45 as as IN cord-352379-q5inrxcm 314 46 a a DT cord-352379-q5inrxcm 314 47 possible possible JJ cord-352379-q5inrxcm 314 48 cause cause NN cord-352379-q5inrxcm 314 49 of of IN cord-352379-q5inrxcm 314 50 severe severe JJ cord-352379-q5inrxcm 314 51 acute acute JJ cord-352379-q5inrxcm 314 52 respiratory respiratory JJ cord-352379-q5inrxcm 314 53 " " '' cord-352379-q5inrxcm 314 54 syndrome syndrome NN cord-352379-q5inrxcm 314 55 Analysis analysis NN cord-352379-q5inrxcm 314 56 of of IN cord-352379-q5inrxcm 314 57 second second JJ cord-352379-q5inrxcm 314 58 - - HYPH cord-352379-q5inrxcm 314 59 site site NN cord-352379-q5inrxcm 314 60 revellants revellant NNS cord-352379-q5inrxcm 314 61 of of IN cord-352379-q5inrxcm 314 62 a a DT cord-352379-q5inrxcm 314 63 murine murine JJ cord-352379-q5inrxcm 314 64 coronavirus coronavirus NN cord-352379-q5inrxcm 314 65 nucleocapsid nucleocapsid NN cord-352379-q5inrxcm 314 66 protein protein NN cord-352379-q5inrxcm 314 67 deletion deletion NN cord-352379-q5inrxcm 314 68 mutant mutant NN cord-352379-q5inrxcm 314 69 and and CC cord-352379-q5inrxcm 314 70 construction construction NN cord-352379-q5inrxcm 314 71 of of IN cord-352379-q5inrxcm 314 72 nucleocapsid nucleocapsid NNP cord-352379-q5inrxcm 314 73 protein protein NN cord-352379-q5inrxcm 314 74 mutants mutant NNS cord-352379-q5inrxcm 314 75 by by IN cord-352379-q5inrxcm 314 76 targeted target VBN cord-352379-q5inrxcm 314 77 RNA RNA NNP cord-352379-q5inrxcm 314 78 recombination recombination NN cord-352379-q5inrxcm 314 79 Efficacy Efficacy NNP cord-352379-q5inrxcm 314 80 of of IN cord-352379-q5inrxcm 314 81 an an DT cord-352379-q5inrxcm 314 82 inactivated inactivate VBN cord-352379-q5inrxcm 314 83 canine canine JJ cord-352379-q5inrxcm 314 84 coronavirus coronavirus NN cord-352379-q5inrxcm 314 85 vaccine vaccine NN cord-352379-q5inrxcm 314 86 in in IN cord-352379-q5inrxcm 314 87 pups pup NNS cord-352379-q5inrxcm 315 1 The the DT cord-352379-q5inrxcm 315 2 transmissible transmissible JJ cord-352379-q5inrxcm 315 3 gastroenteritis gastroenteritis NN cord-352379-q5inrxcm 315 4 coronavirus coronavirus NN cord-352379-q5inrxcm 315 5 contains contain VBZ cord-352379-q5inrxcm 315 6 a a DT cord-352379-q5inrxcm 315 7 spherical spherical JJ cord-352379-q5inrxcm 315 8 core core NN cord-352379-q5inrxcm 315 9 shell shell NN cord-352379-q5inrxcm 315 10 consisting consist VBG cord-352379-q5inrxcm 315 11 of of IN cord-352379-q5inrxcm 315 12 M M NNP cord-352379-q5inrxcm 315 13 and and CC cord-352379-q5inrxcm 315 14 N N NNP cord-352379-q5inrxcm 315 15 proteins protein NNS cord-352379-q5inrxcm 315 16 Characterization characterization NN cord-352379-q5inrxcm 315 17 of of IN cord-352379-q5inrxcm 315 18 a a DT cord-352379-q5inrxcm 315 19 novel novel JJ cord-352379-q5inrxcm 315 20 coronavirus coronavirus NN cord-352379-q5inrxcm 315 21 associated associate VBN cord-352379-q5inrxcm 315 22 with with IN cord-352379-q5inrxcm 315 23 severe severe JJ cord-352379-q5inrxcm 315 24 acute acute JJ cord-352379-q5inrxcm 315 25 respiratory respiratory JJ cord-352379-q5inrxcm 315 26 syndrome syndrome NN cord-352379-q5inrxcm 315 27 Comparative Comparative NNP cord-352379-q5inrxcm 315 28 full full JJ cord-352379-q5inrxcm 315 29 - - HYPH cord-352379-q5inrxcm 315 30 length length NN cord-352379-q5inrxcm 315 31 genome genome NN cord-352379-q5inrxcm 315 32 sequence sequence NN cord-352379-q5inrxcm 315 33 analysis analysis NN cord-352379-q5inrxcm 315 34 of of IN cord-352379-q5inrxcm 315 35 14 14 CD cord-352379-q5inrxcm 315 36 SARS SARS NNP cord-352379-q5inrxcm 315 37 coronavirus coronavirus NN cord-352379-q5inrxcm 315 38 isolates isolate NNS cord-352379-q5inrxcm 315 39 and and CC cord-352379-q5inrxcm 315 40 common common JJ cord-352379-q5inrxcm 315 41 mutations mutation NNS cord-352379-q5inrxcm 315 42 associated associate VBN cord-352379-q5inrxcm 315 43 with with IN cord-352379-q5inrxcm 315 44 putative putative JJ cord-352379-q5inrxcm 315 45 origins origin NNS cord-352379-q5inrxcm 315 46 of of IN cord-352379-q5inrxcm 315 47 infection infection NN cord-352379-q5inrxcm 315 48 Processing processing NN cord-352379-q5inrxcm 315 49 of of IN cord-352379-q5inrxcm 315 50 the the DT cord-352379-q5inrxcm 315 51 coronavirus coronavirus NN cord-352379-q5inrxcm 315 52 MHV MHV NNP cord-352379-q5inrxcm 315 53 - - HYPH cord-352379-q5inrxcm 315 54 JHM JHM NNP cord-352379-q5inrxcm 315 55 polymerase polymerase NN cord-352379-q5inrxcm 316 1 polyprotein polyprotein NNP cord-352379-q5inrxcm 316 2 : : : cord-352379-q5inrxcm 316 3 Identification identification NN cord-352379-q5inrxcm 316 4 of of IN cord-352379-q5inrxcm 316 5 precursors precursor NNS cord-352379-q5inrxcm 316 6 and and CC cord-352379-q5inrxcm 316 7 proteolytic proteolytic JJ cord-352379-q5inrxcm 316 8 products product NNS cord-352379-q5inrxcm 316 9 spanning span VBG cord-352379-q5inrxcm 316 10 400 400 CD cord-352379-q5inrxcm 316 11 kilodaltons kilodalton NNS cord-352379-q5inrxcm 316 12 of of IN cord-352379-q5inrxcm 316 13 ORFla ORFla NNP cord-352379-q5inrxcm 316 14 Colocalization Colocalization NNP cord-352379-q5inrxcm 316 15 and and CC cord-352379-q5inrxcm 316 16 membrane membrane NNP cord-352379-q5inrxcm 316 17 association association NNP cord-352379-q5inrxcm 316 18 of of IN cord-352379-q5inrxcm 316 19 murine murine NNP cord-352379-q5inrxcm 316 20 hepatitis hepatitis NNP cord-352379-q5inrxcm 316 21 virns virns NNP cord-352379-q5inrxcm 316 22 gene gene NNP cord-352379-q5inrxcm 316 23 1 1 CD cord-352379-q5inrxcm 316 24 products product NNS cord-352379-q5inrxcm 316 25 and and CC cord-352379-q5inrxcm 316 26 de de NNP cord-352379-q5inrxcm 316 27 novo novo VB cord-352379-q5inrxcm 316 28 - - HYPH cord-352379-q5inrxcm 316 29 synthesized synthesize VBN cord-352379-q5inrxcm 316 30 viral viral JJ cord-352379-q5inrxcm 316 31 RNA RNA NNP cord-352379-q5inrxcm 316 32 in in IN cord-352379-q5inrxcm 316 33 infected infected JJ cord-352379-q5inrxcm 316 34 cells cell NNS cord-352379-q5inrxcm 317 1 Unique unique JJ cord-352379-q5inrxcm 317 2 and and CC cord-352379-q5inrxcm 317 3 conserved conserve VBN cord-352379-q5inrxcm 317 4 features feature NNS cord-352379-q5inrxcm 317 5 of of IN cord-352379-q5inrxcm 317 6 genome genome NN cord-352379-q5inrxcm 317 7 and and CC cord-352379-q5inrxcm 317 8 proteome proteome NN cord-352379-q5inrxcm 317 9 of of IN cord-352379-q5inrxcm 317 10 SARS SARS NNP cord-352379-q5inrxcm 317 11 - - HYPH cord-352379-q5inrxcm 317 12 coronavirus coronavirus NN cord-352379-q5inrxcm 317 13 , , , cord-352379-q5inrxcm 317 14 an an DT cord-352379-q5inrxcm 317 15 early early JJ cord-352379-q5inrxcm 317 16 split split NN cord-352379-q5inrxcm 317 17 - - HYPH cord-352379-q5inrxcm 317 18 off off NN cord-352379-q5inrxcm 317 19 from from IN cord-352379-q5inrxcm 317 20 the the DT cord-352379-q5inrxcm 317 21 coronavirus coronavirus NN cord-352379-q5inrxcm 317 22 group group NN cord-352379-q5inrxcm 317 23 2 2 CD cord-352379-q5inrxcm 317 24 lineage lineage NN cord-352379-q5inrxcm 317 25 Human human JJ cord-352379-q5inrxcm 317 26 coronavirus coronavirus NN cord-352379-q5inrxcm 317 27 gene gene NN cord-352379-q5inrxcm 317 28 expression expression NN cord-352379-q5inrxcm 317 29 in in IN cord-352379-q5inrxcm 317 30 the the DT cord-352379-q5inrxcm 317 31 brains brain NNS cord-352379-q5inrxcm 317 32 of of IN cord-352379-q5inrxcm 317 33 multiple multiple JJ cord-352379-q5inrxcm 317 34 sclerosis sclerosis NN cord-352379-q5inrxcm 317 35 patients patient NNS cord-352379-q5inrxcm 318 1 Viral viral JJ cord-352379-q5inrxcm 318 2 replicase replicase NN cord-352379-q5inrxcm 318 3 gene gene NN cord-352379-q5inrxcm 318 4 products product NNS cord-352379-q5inrxcm 318 5 suffice suffice VBP cord-352379-q5inrxcm 318 6 for for IN cord-352379-q5inrxcm 318 7 coronavirus coronavirus NN cord-352379-q5inrxcm 318 8 discontinuous discontinuous JJ cord-352379-q5inrxcm 318 9 transcription transcription NN cord-352379-q5inrxcm 318 10 Sorting sorting NN cord-352379-q5inrxcm 318 11 of of IN cord-352379-q5inrxcm 318 12 progeny progeny JJ cord-352379-q5inrxcm 318 13 coronavirus coronavirus NN cord-352379-q5inrxcm 318 14 from from IN cord-352379-q5inrxcm 318 15 condensed condense VBN cord-352379-q5inrxcm 318 16 secretory secretory JJ cord-352379-q5inrxcm 318 17 proteins protein NNS cord-352379-q5inrxcm 318 18 at at IN cord-352379-q5inrxcm 318 19 the the DT cord-352379-q5inrxcm 318 20 exit exit NN cord-352379-q5inrxcm 318 21 from from IN cord-352379-q5inrxcm 318 22 the the DT cord-352379-q5inrxcm 318 23 trans trans NNP cord-352379-q5inrxcm 318 24 - - NNP cord-352379-q5inrxcm 318 25 Golgi Golgi NNP cord-352379-q5inrxcm 318 26 network network NN cord-352379-q5inrxcm 318 27 of of IN cord-352379-q5inrxcm 318 28 AtT20 AtT20 NNP cord-352379-q5inrxcm 318 29 cells cell NNS cord-352379-q5inrxcm 318 30 Recovery recovery NN cord-352379-q5inrxcm 318 31 of of IN cord-352379-q5inrxcm 318 32 transmissible transmissible JJ cord-352379-q5inrxcm 318 33 gastroenteritis gastroenteritis NN cord-352379-q5inrxcm 318 34 virus virus NN cord-352379-q5inrxcm 318 35 from from IN cord-352379-q5inrxcm 318 36 chronically chronically RB cord-352379-q5inrxcm 318 37 infected infect VBN cord-352379-q5inrxcm 318 38 experimental experimental JJ cord-352379-q5inrxcm 318 39 pigs pig NNS cord-352379-q5inrxcm 318 40 Rottier Rottier NNP cord-352379-q5inrxcm 318 41 PJM PJM NNP cord-352379-q5inrxcm 318 42 . . . cord-352379-q5inrxcm 319 1 Nucleocapsid nucleocapsid JJ cord-352379-q5inrxcm 319 2 - - HYPH cord-352379-q5inrxcm 319 3 independent independent JJ cord-352379-q5inrxcm 319 4 assembly assembly NN cord-352379-q5inrxcm 319 5 of of IN cord-352379-q5inrxcm 319 6 coronavirus coronavirus NN cord-352379-q5inrxcm 319 7 - - HYPH cord-352379-q5inrxcm 319 8 like like JJ cord-352379-q5inrxcm 319 9 particles particle NNS cord-352379-q5inrxcm 319 10 by by IN cord-352379-q5inrxcm 319 11 co co NN cord-352379-q5inrxcm 319 12 - - NN cord-352379-q5inrxcm 319 13 expression expression NN cord-352379-q5inrxcm 320 1 of of IN cord-352379-q5inrxcm 320 2 viral viral JJ cord-352379-q5inrxcm 320 3 envelope envelope NN cord-352379-q5inrxcm 320 4 protein protein NN cord-352379-q5inrxcm 320 5 genes gene NNS cord-352379-q5inrxcm 320 6 Evidence evidence NN cord-352379-q5inrxcm 320 7 of of IN cord-352379-q5inrxcm 320 8 natural natural JJ cord-352379-q5inrxcm 320 9 recombination recombination NN cord-352379-q5inrxcm 320 10 within within IN cord-352379-q5inrxcm 320 11 the the DT cord-352379-q5inrxcm 320 12 St St NNP cord-352379-q5inrxcm 320 13 gene gene NN cord-352379-q5inrxcm 320 14 of of IN cord-352379-q5inrxcm 320 15 the the DT cord-352379-q5inrxcm 320 16 infectious infectious JJ cord-352379-q5inrxcm 320 17 bronchitis bronchitis NN cord-352379-q5inrxcm 320 18 virus virus NN cord-352379-q5inrxcm 320 19 Monoclonal monoclonal JJ cord-352379-q5inrxcm 320 20 antibodies antibody NNS cord-352379-q5inrxcm 320 21 to to IN cord-352379-q5inrxcm 320 22 the the DT cord-352379-q5inrxcm 320 23 peplomer peplomer JJ cord-352379-q5inrxcm 320 24 glycoprotein glycoprotein NN cord-352379-q5inrxcm 320 25 of of IN cord-352379-q5inrxcm 320 26 coronavirus coronavirus NN cord-352379-q5inrxcm 320 27 mouse mouse NN cord-352379-q5inrxcm 320 28 hepatitis hepatitis NN cord-352379-q5inrxcm 320 29 virus virus NN cord-352379-q5inrxcm 320 30 identify identify VB cord-352379-q5inrxcm 320 31 two two CD cord-352379-q5inrxcm 320 32 subunits subunit NNS cord-352379-q5inrxcm 320 33 and and CC cord-352379-q5inrxcm 320 34 detect detect VB cord-352379-q5inrxcm 320 35 a a DT cord-352379-q5inrxcm 320 36 conformationaI conformationaI NNP cord-352379-q5inrxcm 320 37 change change NN cord-352379-q5inrxcm 320 38 in in IN cord-352379-q5inrxcm 320 39 the the DT cord-352379-q5inrxcm 320 40 subunit subunit NN cord-352379-q5inrxcm 320 41 released release VBN cord-352379-q5inrxcm 320 42 under under IN cord-352379-q5inrxcm 320 43 mild mild JJ cord-352379-q5inrxcm 320 44 alkaline alkaline JJ cord-352379-q5inrxcm 320 45 conditions condition NNS cord-352379-q5inrxcm 320 46 Antibody antibody NN cord-352379-q5inrxcm 320 47 - - HYPH cord-352379-q5inrxcm 320 48 mediated mediate VBN cord-352379-q5inrxcm 320 49 enhancement enhancement NN cord-352379-q5inrxcm 320 50 of of IN cord-352379-q5inrxcm 320 51 disease disease NN cord-352379-q5inrxcm 320 52 in in IN cord-352379-q5inrxcm 320 53 feline feline JJ cord-352379-q5inrxcm 320 54 infectious infectious JJ cord-352379-q5inrxcm 320 55 peritonitis peritonitis NN cord-352379-q5inrxcm 320 56 : : : cord-352379-q5inrxcm 321 1 comparisons comparison NNS cord-352379-q5inrxcm 321 2 with with IN cord-352379-q5inrxcm 321 3 dengue dengue NN cord-352379-q5inrxcm 321 4 hemorrhagic hemorrhagic JJ cord-352379-q5inrxcm 321 5 fever fever NN cord-352379-q5inrxcm 321 6 Receptor receptor NN cord-352379-q5inrxcm 321 7 for for IN cord-352379-q5inrxcm 321 8 mouse mouse NN cord-352379-q5inrxcm 321 9 hepatitis hepatitis NNP cord-352379-q5inrxcm 321 10 virus virus NN cord-352379-q5inrxcm 321 11 is be VBZ cord-352379-q5inrxcm 321 12 a a DT cord-352379-q5inrxcm 321 13 member member NN cord-352379-q5inrxcm 321 14 of of IN cord-352379-q5inrxcm 321 15 the the DT cord-352379-q5inrxcm 321 16 carcinoembryonic carcinoembryonic NNP cord-352379-q5inrxcm 321 17 antigen antigen NNP cord-352379-q5inrxcm 321 18 family family NN cord-352379-q5inrxcm 321 19 of of IN cord-352379-q5inrxcm 321 20 glycoproteins glycoprotein NNS cord-352379-q5inrxcm 321 21 Human human JJ cord-352379-q5inrxcm 321 22 aminopeptidase aminopeptidase NN cord-352379-q5inrxcm 322 1 N N NNP cord-352379-q5inrxcm 322 2 is be VBZ cord-352379-q5inrxcm 322 3 a a DT cord-352379-q5inrxcm 322 4 receptor receptor NN cord-352379-q5inrxcm 322 5 for for IN cord-352379-q5inrxcm 322 6 human human JJ cord-352379-q5inrxcm 322 7 coronavirus coronavirus NN cord-352379-q5inrxcm 322 8 229E 229e CD cord-352379-q5inrxcm 322 9 Systematic systematic JJ cord-352379-q5inrxcm 322 10 assembly assembly NN cord-352379-q5inrxcm 322 11 of of IN cord-352379-q5inrxcm 322 12 a a DT cord-352379-q5inrxcm 322 13 full full JJ cord-352379-q5inrxcm 322 14 - - HYPH cord-352379-q5inrxcm 322 15 length length NN cord-352379-q5inrxcm 322 16 infectious infectious JJ cord-352379-q5inrxcm 322 17 cDNA cdna NN cord-352379-q5inrxcm 322 18 of of IN cord-352379-q5inrxcm 322 19 mouse mouse NNP cord-352379-q5inrxcm 322 20 hepatitis hepatitis NNP cord-352379-q5inrxcm 322 21 virus virus NN cord-352379-q5inrxcm 322 22 strain strain VBP cord-352379-q5inrxcm 322 23 A59 A59 NNP cord-352379-q5inrxcm 322 24 Biological Biological NNP cord-352379-q5inrxcm 322 25 and and CC cord-352379-q5inrxcm 322 26 genetic genetic JJ cord-352379-q5inrxcm 322 27 characterization characterization NN cord-352379-q5inrxcm 322 28 of of IN cord-352379-q5inrxcm 322 29 a a DT cord-352379-q5inrxcm 322 30 hemagglutinating hemagglutinate VBG cord-352379-q5inrxcm 322 31 coronavirus coronavirus NN cord-352379-q5inrxcm 322 32 isolated isolate VBN cord-352379-q5inrxcm 322 33 from from IN cord-352379-q5inrxcm 322 34 a a DT cord-352379-q5inrxcm 322 35 diarrhoeic diarrhoeic JJ cord-352379-q5inrxcm 322 36 child child NN cord-352379-q5inrxcm 322 37 Processing process VBG cord-352379-q5inrxcm 322 38 ofthe ofthe DT cord-352379-q5inrxcm 322 39 human human JJ cord-352379-q5inrxcm 322 40 coronavirus coronavirus NN cord-352379-q5inrxcm 322 41 229E 229e CD cord-352379-q5inrxcm 322 42 replicase replicase NN cord-352379-q5inrxcm 322 43 polyproteins polyprotein NNS cord-352379-q5inrxcm 322 44 by by IN cord-352379-q5inrxcm 322 45 the the DT cord-352379-q5inrxcm 322 46 virus virus NN cord-352379-q5inrxcm 322 47 - - HYPH cord-352379-q5inrxcm 322 48 encoded encode VBN cord-352379-q5inrxcm 322 49 3C 3c NN cord-352379-q5inrxcm 322 50 - - HYPH cord-352379-q5inrxcm 322 51 like like JJ cord-352379-q5inrxcm 322 52 proteinase proteinase NN cord-352379-q5inrxcm 322 53 : : : cord-352379-q5inrxcm 322 54 Identification identification NN cord-352379-q5inrxcm 322 55 of of IN cord-352379-q5inrxcm 322 56 proteolytic proteolytic JJ cord-352379-q5inrxcm 322 57 products product NNS cord-352379-q5inrxcm 322 58 and and CC cord-352379-q5inrxcm 322 59 cleavage cleavage NN cord-352379-q5inrxcm 322 60 sites site NNS cord-352379-q5inrxcm 322 61 common common JJ cord-352379-q5inrxcm 322 62 to to IN cord-352379-q5inrxcm 322 63 ppla ppla NNP cord-352379-q5inrxcm 322 64 and and CC cord-352379-q5inrxcm 322 65 pplab pplab NNP cord-352379-q5inrxcm 323 1 The the DT cord-352379-q5inrxcm 323 2 Beginning beginning NN cord-352379-q5inrxcm 323 3 of of IN cord-352379-q5inrxcm 323 4 the the DT cord-352379-q5inrxcm 323 5 Unraveling unraveling NN cord-352379-q5inrxcm 323 6 of of IN cord-352379-q5inrxcm 323 7 a a DT cord-352379-q5inrxcm 323 8 New New NNP cord-352379-q5inrxcm 323 9 Coronavirus Coronavirus NNP