id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-010903-kuwy7pbo	Liu, Jiajun	Development of Population and Bayesian Models for Applied Use in Patients Receiving Cefepime	2020-03-05		.txt	text/plain	3735	205	41	This study sought to develop and evaluate a unified population pharmacokinetic model in both pediatric and adult patients receiving cefepime treatment. The purpose of this study was to: (1) develop and evaluate a unified cefepime population PK model for adult and pediatric patients, and (2) construct an individualized model that can be utilized to deliver precision cefepime dosing. A unified cefepime population pharmacokinetic model has been developed from adult and pediatric patients and evaluates well in independent populations. The base one-and two-compartment models (without covariate adjustment) produced reasonable fits for observed and Bayesian posterior-predicted cefepime concentrations (R 2 = 84.7% and 85.2%, respectively), but population estimates were unsatisfactory (R 2 = 22.7% and 27.8%, respectively) ( Table 1) . This study created a population and individual PK model for adult and pediatric patients and can serve as a Bayesian prior for precision dosing.	./cache/cord-010903-kuwy7pbo.txt	./txt/cord-010903-kuwy7pbo.txt