id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-016954-l3b6n7ej	Young, Colin R.	Animal Models of Multiple Sclerosis	2008		.txt	text/plain	9705	495	44	The relative inaccessibility and sensitivity of the central nervous system (CNS) in humans preclude studies on disease pathogenesis, and so much of our understanding of infections and immune responses has been derived from experimental animal models. Viral models are immensely relevant since epidemiological studies suggest an environmental factor, and almost all naturally occurring CNS demyelinating diseases of humans and animals of known etiology are caused by a virus. The most widely studied models of MS are the experimental infections of rodents resulting in an inflammatory demyelinating disease in the CNS, such as Theiler's virus, mouse hepatitis virus, and Semliki Forest virus. Theiler's virus-induced demyelination, a model for human MS, bears several similarities to the human disease: an immune-mediated demyelination, involvement of CD4 + helper T cells and CD8 + cytotoxic T cells, delayed type hypersensitivity responses to viral antigens and autoantigens, and pathology.	./cache/cord-016954-l3b6n7ej.txt	./txt/cord-016954-l3b6n7ej.txt