id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-273815-7ftztaqn	Gupta, R. K.	Systematic evaluation and external validation of 22 prognostic models among hospitalised adults with COVID-19: An observational cohort study	2020-07-26		.txt	text/plain	4918	288	40	We also assessed the discrimination of each candidate model for standardised outcomes of: (a) our composite endpoint of clinical deterioration; and (b) mortality, across a range of pre-specified time horizons from admission (7 days, 14 days, 30 days and any time during hospital admission), by calculating time-dependent AUROCs (with cumulative sensitivity and dynamic specificity) 18 . In order to further benchmark the performance of candidate prognostic models, we then computed AUROCs for a limited number of univariable predictors considered to be of highest importance a priori, based on clinical knowledge and existing data, for prediction of our composite endpoints of clinical deterioration and mortality (7 days, 14 days, 30 days and any time during hospital admission). We compared net benefit for each prognostic model (for its original intended endpoint) to the strategies of treating all patients, treating no patients, and using the most discriminating univariable predictor for either deterioration (i.e. oxygen saturation on air) or mortality (i.e. patient age) to stratify treatment (Supplementary Figure 9 ).	./cache/cord-273815-7ftztaqn.txt	./txt/cord-273815-7ftztaqn.txt