id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-276218-dcg9oq6y	Kim, Jihoon	Human organoids: model systems for human biology and medicine	2020-07-07		.txt	text/plain	10681	496	38	The use of classical cell line and animal model systems in biomedical research during the late twentieth and early twenty-first centuries has been successful in many areas, such as improving our understanding of cellular signalling pathways, identifying potential drug targets and guiding the design of candidate drugs for pathologies including cancer and infectious disease. The advent of human induced pluripotent stem cell (iPSC) technology and diverse human AdSC culture methods has made it possible, for the first time, to generate laboratory models specific to an individual 32 . A number of studies have used 3D human stem cell-derived systems, including neurosphere culture and brain organoid models, to reveal the effect of ZIKV infection on human brain development 80, 81 .	./cache/cord-276218-dcg9oq6y.txt	./txt/cord-276218-dcg9oq6y.txt