id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-301505-np4nr7gg	Lin, Xin	Two types of transmembrane homomeric interactions in the integrin receptor family are evolutionarily conserved	2006-01-27		.txt	text/plain	5266	279	49	Our results show that two models, one involving a GxxxG‐like motif (model I) and an almost opposite form of interaction (model II) are conserved across all α and β integrin types, both in homodimers and homotrimers, with different specificities. 21 Using the TOXCAT assay, 22 a test that measures the oligomerization of a chimeric protein containing a TM helix in the Escherichia coli inner membrane via transcriptional activation of the gene for chloramphenicol acetyltransferase, a sequence critical for integrin ␣IIb-TM homodimerization that involved the GxxxG motif was suggested by Li et al. Our computational results have been obtained independently from any previous experimental data, and clearly show that two right-handed types of homomeric interaction in the transmembrane domain of ␣ and ␤ integrins (models I and II) are evolutionarily conserved.	./cache/cord-301505-np4nr7gg.txt	./txt/cord-301505-np4nr7gg.txt