id	sid	tid	token	lemma	pos
cord-007726-bqlf72fe	1	1	key	key	NN
cord-007726-bqlf72fe	1	2	:	:	:
cord-007726-bqlf72fe	1	3	cord-007726-bqlf72fe	cord-007726-bqlf72fe	CD
cord-007726-bqlf72fe	1	4	authors	author	NNS
cord-007726-bqlf72fe	1	5	:	:	:
cord-007726-bqlf72fe	1	6	Rydell	Rydell	NNP
cord-007726-bqlf72fe	1	7	-	-	HYPH
cord-007726-bqlf72fe	1	8	Törmänen	Törmänen	NNP
cord-007726-bqlf72fe	1	9	,	,	,
cord-007726-bqlf72fe	1	10	Kristina	Kristina	NNP
cord-007726-bqlf72fe	1	11	;	;	:
cord-007726-bqlf72fe	1	12	Johnson	Johnson	NNP
cord-007726-bqlf72fe	1	13	,	,	,
cord-007726-bqlf72fe	1	14	Jill	Jill	NNP
cord-007726-bqlf72fe	1	15	R.	R.	NNP
cord-007726-bqlf72fe	1	16	title	title	NN
cord-007726-bqlf72fe	1	17	:	:	:
cord-007726-bqlf72fe	1	18	The	the	DT
cord-007726-bqlf72fe	1	19	Applicability	Applicability	NNP
cord-007726-bqlf72fe	1	20	of	of	IN
cord-007726-bqlf72fe	1	21	Mouse	Mouse	NNP
cord-007726-bqlf72fe	1	22	Models	Models	NNPS
cord-007726-bqlf72fe	1	23	to	to	IN
cord-007726-bqlf72fe	1	24	the	the	DT
cord-007726-bqlf72fe	1	25	Study	Study	NNP
cord-007726-bqlf72fe	1	26	of	of	IN
cord-007726-bqlf72fe	1	27	Human	Human	NNP
cord-007726-bqlf72fe	1	28	Disease	Disease	NNP
cord-007726-bqlf72fe	1	29	date	date	NN
cord-007726-bqlf72fe	1	30	:	:	:
cord-007726-bqlf72fe	1	31	2018	2018	CD
cord-007726-bqlf72fe	1	32	-	-	HYPH
cord-007726-bqlf72fe	1	33	11	11	CD
cord-007726-bqlf72fe	1	34	-	-	HYPH
cord-007726-bqlf72fe	1	35	09	09	CD
cord-007726-bqlf72fe	1	36	journal	journal	NN
cord-007726-bqlf72fe	1	37	:	:	:
cord-007726-bqlf72fe	1	38	Mouse	Mouse	NNP
cord-007726-bqlf72fe	1	39	Cell	cell	NN
cord-007726-bqlf72fe	1	40	Culture	culture	NN
cord-007726-bqlf72fe	1	41	DOI	doi	NN
cord-007726-bqlf72fe	1	42	:	:	:
cord-007726-bqlf72fe	1	43	10.1007/978	10.1007/978	CD
cord-007726-bqlf72fe	1	44	-	-	HYPH
cord-007726-bqlf72fe	1	45	1	1	CD
cord-007726-bqlf72fe	1	46	-	-	HYPH
cord-007726-bqlf72fe	1	47	4939	4939	CD
cord-007726-bqlf72fe	1	48	-	-	HYPH
cord-007726-bqlf72fe	1	49	9086	9086	CD
cord-007726-bqlf72fe	1	50	-	-	SYM
cord-007726-bqlf72fe	1	51	3_1	3_1	CD
cord-007726-bqlf72fe	2	1	sha	sha	NNP
cord-007726-bqlf72fe	2	2	:	:	:
cord-007726-bqlf72fe	3	1	6100ab3c0e33aae33997f4a61f31f280c32cf3d3	6100ab3c0e33aae33997f4a61f31f280c32cf3d3	CD
cord-007726-bqlf72fe	3	2	doc_id	doc_id	CD
cord-007726-bqlf72fe	3	3	:	:	:
cord-007726-bqlf72fe	3	4	7726	7726	CD
cord-007726-bqlf72fe	3	5	cord_uid	cord_uid	NNS
cord-007726-bqlf72fe	3	6	:	:	:
cord-007726-bqlf72fe	4	1	bqlf72fe	bqlf72fe	NNP
cord-007726-bqlf72fe	5	1	The	the	DT
cord-007726-bqlf72fe	5	2	laboratory	laboratory	NN
cord-007726-bqlf72fe	5	3	mouse	mouse	NN
cord-007726-bqlf72fe	5	4	Mus	Mus	NNP
cord-007726-bqlf72fe	5	5	musculus	musculus	NN
cord-007726-bqlf72fe	5	6	has	have	VBZ
cord-007726-bqlf72fe	5	7	long	long	RB
cord-007726-bqlf72fe	5	8	been	be	VBN
cord-007726-bqlf72fe	5	9	used	use	VBN
cord-007726-bqlf72fe	5	10	as	as	IN
cord-007726-bqlf72fe	5	11	a	a	DT
cord-007726-bqlf72fe	5	12	model	model	NN
cord-007726-bqlf72fe	5	13	organism	organism	NN
cord-007726-bqlf72fe	5	14	to	to	TO
cord-007726-bqlf72fe	5	15	test	test	VB
cord-007726-bqlf72fe	5	16	hypotheses	hypothesis	NNS
cord-007726-bqlf72fe	5	17	and	and	CC
cord-007726-bqlf72fe	5	18	treatments	treatment	NNS
cord-007726-bqlf72fe	5	19	related	relate	VBN
cord-007726-bqlf72fe	5	20	to	to	IN
cord-007726-bqlf72fe	5	21	understanding	understand	VBG
cord-007726-bqlf72fe	5	22	the	the	DT
cord-007726-bqlf72fe	5	23	mechanisms	mechanism	NNS
cord-007726-bqlf72fe	5	24	of	of	IN
cord-007726-bqlf72fe	5	25	disease	disease	NN
cord-007726-bqlf72fe	5	26	in	in	IN
cord-007726-bqlf72fe	5	27	humans	human	NNS
cord-007726-bqlf72fe	5	28	;	;	:
cord-007726-bqlf72fe	5	29	however	however	RB
cord-007726-bqlf72fe	5	30	,	,	,
cord-007726-bqlf72fe	5	31	for	for	IN
cord-007726-bqlf72fe	5	32	these	these	DT
cord-007726-bqlf72fe	5	33	experiments	experiment	NNS
cord-007726-bqlf72fe	5	34	to	to	TO
cord-007726-bqlf72fe	5	35	be	be	VB
cord-007726-bqlf72fe	5	36	relevant	relevant	JJ
cord-007726-bqlf72fe	5	37	,	,	,
cord-007726-bqlf72fe	5	38	it	-PRON-	PRP
cord-007726-bqlf72fe	5	39	is	be	VBZ
cord-007726-bqlf72fe	5	40	important	important	JJ
cord-007726-bqlf72fe	5	41	to	to	TO
cord-007726-bqlf72fe	5	42	know	know	VB
cord-007726-bqlf72fe	5	43	the	the	DT
cord-007726-bqlf72fe	5	44	complex	complex	JJ
cord-007726-bqlf72fe	5	45	ways	way	NNS
cord-007726-bqlf72fe	5	46	in	in	IN
cord-007726-bqlf72fe	5	47	which	which	WDT
cord-007726-bqlf72fe	5	48	mice	mouse	NNS
cord-007726-bqlf72fe	5	49	are	be	VBP
cord-007726-bqlf72fe	5	50	similar	similar	JJ
cord-007726-bqlf72fe	5	51	to	to	IN
cord-007726-bqlf72fe	5	52	humans	human	NNS
cord-007726-bqlf72fe	5	53	and	and	CC
cord-007726-bqlf72fe	5	54	,	,	,
cord-007726-bqlf72fe	5	55	crucially	crucially	RB
cord-007726-bqlf72fe	5	56	,	,	,
cord-007726-bqlf72fe	5	57	the	the	DT
cord-007726-bqlf72fe	5	58	ways	way	NNS
cord-007726-bqlf72fe	5	59	in	in	IN
cord-007726-bqlf72fe	5	60	which	which	WDT
cord-007726-bqlf72fe	5	61	they	-PRON-	PRP
cord-007726-bqlf72fe	5	62	differ	differ	VBP
cord-007726-bqlf72fe	5	63	.	.	.
cord-007726-bqlf72fe	6	1	In	in	IN
cord-007726-bqlf72fe	6	2	this	this	DT
cord-007726-bqlf72fe	6	3	chapter	chapter	NN
cord-007726-bqlf72fe	6	4	,	,	,
cord-007726-bqlf72fe	6	5	an	an	DT
cord-007726-bqlf72fe	6	6	in	in	IN
cord-007726-bqlf72fe	6	7	-	-	HYPH
cord-007726-bqlf72fe	6	8	depth	depth	NN
cord-007726-bqlf72fe	6	9	analysis	analysis	NN
cord-007726-bqlf72fe	6	10	of	of	IN
cord-007726-bqlf72fe	6	11	these	these	DT
cord-007726-bqlf72fe	6	12	similarities	similarity	NNS
cord-007726-bqlf72fe	6	13	and	and	CC
cord-007726-bqlf72fe	6	14	differences	difference	NNS
cord-007726-bqlf72fe	6	15	is	be	VBZ
cord-007726-bqlf72fe	6	16	provided	provide	VBN
cord-007726-bqlf72fe	6	17	to	to	TO
cord-007726-bqlf72fe	6	18	allow	allow	VB
cord-007726-bqlf72fe	6	19	researchers	researcher	NNS
cord-007726-bqlf72fe	6	20	to	to	TO
cord-007726-bqlf72fe	6	21	use	use	VB
cord-007726-bqlf72fe	6	22	mouse	mouse	NN
cord-007726-bqlf72fe	6	23	models	model	NNS
cord-007726-bqlf72fe	6	24	of	of	IN
cord-007726-bqlf72fe	6	25	human	human	JJ
cord-007726-bqlf72fe	6	26	disease	disease	NN
cord-007726-bqlf72fe	6	27	and	and	CC
cord-007726-bqlf72fe	6	28	primary	primary	JJ
cord-007726-bqlf72fe	6	29	cells	cell	NNS
cord-007726-bqlf72fe	6	30	derived	derive	VBN
cord-007726-bqlf72fe	6	31	from	from	IN
cord-007726-bqlf72fe	6	32	these	these	DT
cord-007726-bqlf72fe	6	33	animal	animal	NN
cord-007726-bqlf72fe	6	34	models	model	NNS
cord-007726-bqlf72fe	6	35	under	under	IN
cord-007726-bqlf72fe	6	36	the	the	DT
cord-007726-bqlf72fe	6	37	most	most	RBS
cord-007726-bqlf72fe	6	38	appropriate	appropriate	JJ
cord-007726-bqlf72fe	6	39	and	and	CC
cord-007726-bqlf72fe	6	40	meaningful	meaningful	JJ
cord-007726-bqlf72fe	6	41	conditions	condition	NNS
cord-007726-bqlf72fe	6	42	.	.	.
cord-007726-bqlf72fe	7	1	Although	although	IN
cord-007726-bqlf72fe	7	2	there	there	EX
cord-007726-bqlf72fe	7	3	are	be	VBP
cord-007726-bqlf72fe	7	4	considerable	considerable	JJ
cord-007726-bqlf72fe	7	5	differences	difference	NNS
cord-007726-bqlf72fe	7	6	between	between	IN
cord-007726-bqlf72fe	7	7	mice	mouse	NNS
cord-007726-bqlf72fe	7	8	and	and	CC
cord-007726-bqlf72fe	7	9	humans	human	NNS
cord-007726-bqlf72fe	7	10	,	,	,
cord-007726-bqlf72fe	7	11	particularly	particularly	RB
cord-007726-bqlf72fe	7	12	regarding	regard	VBG
cord-007726-bqlf72fe	7	13	genetics	genetic	NNS
cord-007726-bqlf72fe	7	14	,	,	,
cord-007726-bqlf72fe	7	15	physiology	physiology	NN
cord-007726-bqlf72fe	7	16	,	,	,
cord-007726-bqlf72fe	7	17	and	and	CC
cord-007726-bqlf72fe	7	18	immunology	immunology	NN
cord-007726-bqlf72fe	7	19	,	,	,
cord-007726-bqlf72fe	7	20	a	a	DT
cord-007726-bqlf72fe	7	21	more	more	RBR
cord-007726-bqlf72fe	7	22	thorough	thorough	JJ
cord-007726-bqlf72fe	7	23	understanding	understanding	NN
cord-007726-bqlf72fe	7	24	of	of	IN
cord-007726-bqlf72fe	7	25	these	these	DT
cord-007726-bqlf72fe	7	26	differences	difference	NNS
cord-007726-bqlf72fe	7	27	and	and	CC
cord-007726-bqlf72fe	7	28	their	-PRON-	PRP$
cord-007726-bqlf72fe	7	29	effects	effect	NNS
cord-007726-bqlf72fe	7	30	on	on	IN
cord-007726-bqlf72fe	7	31	the	the	DT
cord-007726-bqlf72fe	7	32	function	function	NN
cord-007726-bqlf72fe	7	33	of	of	IN
cord-007726-bqlf72fe	7	34	the	the	DT
cord-007726-bqlf72fe	7	35	whole	whole	JJ
cord-007726-bqlf72fe	7	36	organism	organism	NN
cord-007726-bqlf72fe	7	37	will	will	MD
cord-007726-bqlf72fe	7	38	provide	provide	VB
cord-007726-bqlf72fe	7	39	deeper	deep	JJR
cord-007726-bqlf72fe	7	40	insights	insight	NNS
cord-007726-bqlf72fe	7	41	into	into	IN
cord-007726-bqlf72fe	7	42	relevant	relevant	JJ
cord-007726-bqlf72fe	7	43	disease	disease	NN
cord-007726-bqlf72fe	7	44	mechanisms	mechanism	NNS
cord-007726-bqlf72fe	7	45	and	and	CC
cord-007726-bqlf72fe	7	46	potential	potential	JJ
cord-007726-bqlf72fe	7	47	drug	drug	NN
cord-007726-bqlf72fe	7	48	targets	target	NNS
cord-007726-bqlf72fe	7	49	for	for	IN
cord-007726-bqlf72fe	7	50	further	further	JJ
cord-007726-bqlf72fe	7	51	clinical	clinical	JJ
cord-007726-bqlf72fe	7	52	investigation	investigation	NN
cord-007726-bqlf72fe	7	53	.	.	.
cord-007726-bqlf72fe	8	1	Using	use	VBG
cord-007726-bqlf72fe	8	2	specific	specific	JJ
cord-007726-bqlf72fe	8	3	examples	example	NNS
cord-007726-bqlf72fe	8	4	of	of	IN
cord-007726-bqlf72fe	8	5	mouse	mouse	NN
cord-007726-bqlf72fe	8	6	models	model	NNS
cord-007726-bqlf72fe	8	7	of	of	IN
cord-007726-bqlf72fe	8	8	human	human	JJ
cord-007726-bqlf72fe	8	9	lung	lung	NN
cord-007726-bqlf72fe	8	10	disease	disease	NN
cord-007726-bqlf72fe	8	11	,	,	,
cord-007726-bqlf72fe	8	12	i.e.	i.e.	FW
cord-007726-bqlf72fe	8	13	,	,	,
cord-007726-bqlf72fe	8	14	asthma	asthma	NN
cord-007726-bqlf72fe	8	15	,	,	,
cord-007726-bqlf72fe	8	16	chronic	chronic	JJ
cord-007726-bqlf72fe	8	17	obstructive	obstructive	JJ
cord-007726-bqlf72fe	8	18	pulmonary	pulmonary	JJ
cord-007726-bqlf72fe	8	19	disease	disease	NN
cord-007726-bqlf72fe	8	20	,	,	,
cord-007726-bqlf72fe	8	21	and	and	CC
cord-007726-bqlf72fe	8	22	pulmonary	pulmonary	JJ
cord-007726-bqlf72fe	8	23	fibrosis	fibrosis	NN
cord-007726-bqlf72fe	8	24	,	,	,
cord-007726-bqlf72fe	8	25	this	this	DT
cord-007726-bqlf72fe	8	26	chapter	chapter	NN
cord-007726-bqlf72fe	8	27	explores	explore	VBZ
cord-007726-bqlf72fe	8	28	the	the	DT
cord-007726-bqlf72fe	8	29	most	most	RBS
cord-007726-bqlf72fe	8	30	salient	salient	JJ
cord-007726-bqlf72fe	8	31	features	feature	NNS
cord-007726-bqlf72fe	8	32	of	of	IN
cord-007726-bqlf72fe	8	33	mouse	mouse	NN
cord-007726-bqlf72fe	8	34	models	model	NNS
cord-007726-bqlf72fe	8	35	of	of	IN
cord-007726-bqlf72fe	8	36	human	human	JJ
cord-007726-bqlf72fe	8	37	disease	disease	NN
cord-007726-bqlf72fe	8	38	and	and	CC
cord-007726-bqlf72fe	8	39	provides	provide	VBZ
cord-007726-bqlf72fe	8	40	a	a	DT
cord-007726-bqlf72fe	8	41	full	full	JJ
cord-007726-bqlf72fe	8	42	assessment	assessment	NN
cord-007726-bqlf72fe	8	43	of	of	IN
cord-007726-bqlf72fe	8	44	the	the	DT
cord-007726-bqlf72fe	8	45	advantages	advantage	NNS
cord-007726-bqlf72fe	8	46	and	and	CC
cord-007726-bqlf72fe	8	47	limitations	limitation	NNS
cord-007726-bqlf72fe	8	48	of	of	IN
cord-007726-bqlf72fe	8	49	these	these	DT
cord-007726-bqlf72fe	8	50	models	model	NNS
cord-007726-bqlf72fe	8	51	,	,	,
cord-007726-bqlf72fe	8	52	focusing	focus	VBG
cord-007726-bqlf72fe	8	53	on	on	IN
cord-007726-bqlf72fe	8	54	the	the	DT
cord-007726-bqlf72fe	8	55	relevance	relevance	NN
cord-007726-bqlf72fe	8	56	of	of	IN
cord-007726-bqlf72fe	8	57	disease	disease	NN
cord-007726-bqlf72fe	8	58	induction	induction	NN
cord-007726-bqlf72fe	8	59	and	and	CC
cord-007726-bqlf72fe	8	60	their	-PRON-	PRP$
cord-007726-bqlf72fe	8	61	ability	ability	NN
cord-007726-bqlf72fe	8	62	to	to	TO
cord-007726-bqlf72fe	8	63	replicate	replicate	VB
cord-007726-bqlf72fe	8	64	critical	critical	JJ
cord-007726-bqlf72fe	8	65	features	feature	NNS
cord-007726-bqlf72fe	8	66	of	of	IN
cord-007726-bqlf72fe	8	67	human	human	JJ
cord-007726-bqlf72fe	8	68	disease	disease	NN
cord-007726-bqlf72fe	8	69	pathophysiology	pathophysiology	NN
cord-007726-bqlf72fe	8	70	and	and	CC
cord-007726-bqlf72fe	8	71	response	response	NN
cord-007726-bqlf72fe	8	72	to	to	IN
cord-007726-bqlf72fe	8	73	treatment	treatment	NN
cord-007726-bqlf72fe	8	74	.	.	.
cord-007726-bqlf72fe	9	1	The	the	DT
cord-007726-bqlf72fe	9	2	chapter	chapter	NN
cord-007726-bqlf72fe	9	3	concludes	conclude	VBZ
cord-007726-bqlf72fe	9	4	with	with	IN
cord-007726-bqlf72fe	9	5	a	a	DT
cord-007726-bqlf72fe	9	6	discussion	discussion	NN
cord-007726-bqlf72fe	9	7	on	on	IN
cord-007726-bqlf72fe	9	8	the	the	DT
cord-007726-bqlf72fe	9	9	future	future	NN
cord-007726-bqlf72fe	9	10	of	of	IN
cord-007726-bqlf72fe	9	11	using	use	VBG
cord-007726-bqlf72fe	9	12	mice	mouse	NNS
cord-007726-bqlf72fe	9	13	in	in	IN
cord-007726-bqlf72fe	9	14	medical	medical	JJ
cord-007726-bqlf72fe	9	15	research	research	NN
cord-007726-bqlf72fe	9	16	with	with	IN
cord-007726-bqlf72fe	9	17	regard	regard	NN
cord-007726-bqlf72fe	9	18	to	to	IN
cord-007726-bqlf72fe	9	19	ethical	ethical	JJ
cord-007726-bqlf72fe	9	20	and	and	CC
cord-007726-bqlf72fe	9	21	technological	technological	JJ
cord-007726-bqlf72fe	9	22	considerations	consideration	NNS
cord-007726-bqlf72fe	9	23	.	.	.
cord-007726-bqlf72fe	10	1	Although	although	IN
cord-007726-bqlf72fe	10	2	the	the	DT
cord-007726-bqlf72fe	10	3	genetic	genetic	JJ
cord-007726-bqlf72fe	10	4	lineages	lineage	NNS
cord-007726-bqlf72fe	10	5	of	of	IN
cord-007726-bqlf72fe	10	6	mice	mouse	NNS
cord-007726-bqlf72fe	10	7	and	and	CC
cord-007726-bqlf72fe	10	8	humans	human	NNS
cord-007726-bqlf72fe	10	9	diverged	diverge	VBD
cord-007726-bqlf72fe	10	10	around	around	RB
cord-007726-bqlf72fe	10	11	75	75	CD
cord-007726-bqlf72fe	10	12	million	million	CD
cord-007726-bqlf72fe	10	13	years	year	NNS
cord-007726-bqlf72fe	10	14	ago	ago	RB
cord-007726-bqlf72fe	10	15	,	,	,
cord-007726-bqlf72fe	10	16	these	these	DT
cord-007726-bqlf72fe	10	17	two	two	CD
cord-007726-bqlf72fe	10	18	species	specie	NNS
cord-007726-bqlf72fe	10	19	have	have	VBP
cord-007726-bqlf72fe	10	20	evolved	evolve	VBN
cord-007726-bqlf72fe	10	21	to	to	TO
cord-007726-bqlf72fe	10	22	live	live	VB
cord-007726-bqlf72fe	10	23	together	together	RB
cord-007726-bqlf72fe	10	24	,	,	,
cord-007726-bqlf72fe	10	25	particularly	particularly	RB
cord-007726-bqlf72fe	10	26	since	since	IN
cord-007726-bqlf72fe	10	27	the	the	DT
cord-007726-bqlf72fe	10	28	development	development	NN
cord-007726-bqlf72fe	10	29	of	of	IN
cord-007726-bqlf72fe	10	30	agriculture	agriculture	NN
cord-007726-bqlf72fe	10	31	.	.	.
cord-007726-bqlf72fe	11	1	For	for	IN
cord-007726-bqlf72fe	11	2	millennia	millennium	NNS
cord-007726-bqlf72fe	11	3	,	,	,
cord-007726-bqlf72fe	11	4	mice	mouse	NNS
cord-007726-bqlf72fe	11	5	(	(	-LRB-
cord-007726-bqlf72fe	11	6	Mus	Mus	NNP
cord-007726-bqlf72fe	11	7	musculus	musculus	NN
cord-007726-bqlf72fe	11	8	)	)	-RRB-
cord-007726-bqlf72fe	11	9	were	be	VBD
cord-007726-bqlf72fe	11	10	considered	consider	VBN
cord-007726-bqlf72fe	11	11	to	to	TO
cord-007726-bqlf72fe	11	12	be	be	VB
cord-007726-bqlf72fe	11	13	pests	pest	NNS
cord-007726-bqlf72fe	11	14	due	due	JJ
cord-007726-bqlf72fe	11	15	to	to	IN
cord-007726-bqlf72fe	11	16	their	-PRON-	PRP$
cord-007726-bqlf72fe	11	17	propensity	propensity	NN
cord-007726-bqlf72fe	11	18	to	to	TO
cord-007726-bqlf72fe	11	19	ravenously	ravenously	RB
cord-007726-bqlf72fe	11	20	consume	consume	VB
cord-007726-bqlf72fe	11	21	stored	store	VBN
cord-007726-bqlf72fe	11	22	foodstuff	foodstuff	NN
cord-007726-bqlf72fe	11	23	(	(	-LRB-
cord-007726-bqlf72fe	11	24	mush	mush	JJ
cord-007726-bqlf72fe	11	25	in	in	IN
cord-007726-bqlf72fe	11	26	ancient	ancient	JJ
cord-007726-bqlf72fe	11	27	Sanskrit	Sanskrit	NNP
cord-007726-bqlf72fe	11	28	means	mean	VBZ
cord-007726-bqlf72fe	11	29	"	"	``
cord-007726-bqlf72fe	11	30	to	to	TO
cord-007726-bqlf72fe	11	31	steal	steal	VB
cord-007726-bqlf72fe	11	32	"	"	''
cord-007726-bqlf72fe	11	33	[	[	-LRB-
cord-007726-bqlf72fe	11	34	1	1	CD
cord-007726-bqlf72fe	11	35	]	]	-RRB-
cord-007726-bqlf72fe	11	36	)	)	-RRB-
cord-007726-bqlf72fe	11	37	and	and	CC
cord-007726-bqlf72fe	11	38	their	-PRON-	PRP$
cord-007726-bqlf72fe	11	39	ability	ability	NN
cord-007726-bqlf72fe	11	40	to	to	TO
cord-007726-bqlf72fe	11	41	adapt	adapt	VB
cord-007726-bqlf72fe	11	42	to	to	IN
cord-007726-bqlf72fe	11	43	a	a	DT
cord-007726-bqlf72fe	11	44	wide	wide	JJ
cord-007726-bqlf72fe	11	45	range	range	NN
cord-007726-bqlf72fe	11	46	of	of	IN
cord-007726-bqlf72fe	11	47	environmental	environmental	JJ
cord-007726-bqlf72fe	11	48	conditions	condition	NNS
cord-007726-bqlf72fe	11	49	.	.	.
cord-007726-bqlf72fe	12	1	Since	since	IN
cord-007726-bqlf72fe	12	2	the	the	DT
cord-007726-bqlf72fe	12	3	1700s	1700s	CD
cord-007726-bqlf72fe	12	4	,	,	,
cord-007726-bqlf72fe	12	5	domesticated	domesticated	JJ
cord-007726-bqlf72fe	12	6	mice	mouse	NNS
cord-007726-bqlf72fe	12	7	have	have	VBP
cord-007726-bqlf72fe	12	8	been	be	VBN
cord-007726-bqlf72fe	12	9	bred	breed	VBN
cord-007726-bqlf72fe	12	10	and	and	CC
cord-007726-bqlf72fe	12	11	kept	keep	VBN
cord-007726-bqlf72fe	12	12	as	as	IN
cord-007726-bqlf72fe	12	13	companion	companion	NN
cord-007726-bqlf72fe	12	14	animals	animal	NNS
cord-007726-bqlf72fe	12	15	,	,	,
cord-007726-bqlf72fe	12	16	and	and	CC
cord-007726-bqlf72fe	12	17	in	in	IN
cord-007726-bqlf72fe	12	18	Victorian	Victorian	NNP
cord-007726-bqlf72fe	12	19	England	England	NNP
cord-007726-bqlf72fe	12	20	,	,	,
cord-007726-bqlf72fe	12	21	"	"	``
cord-007726-bqlf72fe	12	22	fancy	fancy	JJ
cord-007726-bqlf72fe	12	23	"	"	''
cord-007726-bqlf72fe	12	24	mice	mouse	NNS
cord-007726-bqlf72fe	12	25	were	be	VBD
cord-007726-bqlf72fe	12	26	prized	prize	VBN
cord-007726-bqlf72fe	12	27	for	for	IN
cord-007726-bqlf72fe	12	28	their	-PRON-	PRP$
cord-007726-bqlf72fe	12	29	variations	variation	NNS
cord-007726-bqlf72fe	12	30	in	in	IN
cord-007726-bqlf72fe	12	31	coat	coat	NN
cord-007726-bqlf72fe	12	32	color	color	NN
cord-007726-bqlf72fe	12	33	and	and	CC
cord-007726-bqlf72fe	12	34	comportment	comportment	NN
cord-007726-bqlf72fe	12	35	;	;	:
cord-007726-bqlf72fe	12	36	these	these	DT
cord-007726-bqlf72fe	12	37	mouse	mouse	NN
cord-007726-bqlf72fe	12	38	strains	strain	NNS
cord-007726-bqlf72fe	12	39	were	be	VBD
cord-007726-bqlf72fe	12	40	the	the	DT
cord-007726-bqlf72fe	12	41	forerunners	forerunner	NNS
cord-007726-bqlf72fe	12	42	to	to	IN
cord-007726-bqlf72fe	12	43	the	the	DT
cord-007726-bqlf72fe	12	44	strains	strain	NNS
cord-007726-bqlf72fe	12	45	used	use	VBN
cord-007726-bqlf72fe	12	46	in	in	IN
cord-007726-bqlf72fe	12	47	the	the	DT
cord-007726-bqlf72fe	12	48	laboratory	laboratory	NN
cord-007726-bqlf72fe	12	49	today	today	NN
cord-007726-bqlf72fe	12	50	.	.	.
cord-007726-bqlf72fe	13	1	Robert	Robert	NNP
cord-007726-bqlf72fe	13	2	Hooke	Hooke	NNP
cord-007726-bqlf72fe	13	3	performed	perform	VBD
cord-007726-bqlf72fe	13	4	the	the	DT
cord-007726-bqlf72fe	13	5	first	first	JJ
cord-007726-bqlf72fe	13	6	recorded	recorded	JJ
cord-007726-bqlf72fe	13	7	inquiry	inquiry	NN
cord-007726-bqlf72fe	13	8	-	-	HYPH
cord-007726-bqlf72fe	13	9	driven	drive	VBN
cord-007726-bqlf72fe	13	10	experiments	experiment	NNS
cord-007726-bqlf72fe	13	11	on	on	IN
cord-007726-bqlf72fe	13	12	mice	mouse	NNS
cord-007726-bqlf72fe	13	13	in	in	IN
cord-007726-bqlf72fe	13	14	1664	1664	CD
cord-007726-bqlf72fe	13	15	,	,	,
cord-007726-bqlf72fe	13	16	when	when	WRB
cord-007726-bqlf72fe	13	17	he	-PRON-	PRP
cord-007726-bqlf72fe	13	18	investigated	investigate	VBD
cord-007726-bqlf72fe	13	19	the	the	DT
cord-007726-bqlf72fe	13	20	effects	effect	NNS
cord-007726-bqlf72fe	13	21	of	of	IN
cord-007726-bqlf72fe	13	22	changes	change	NNS
cord-007726-bqlf72fe	13	23	in	in	IN
cord-007726-bqlf72fe	13	24	air	air	NN
cord-007726-bqlf72fe	13	25	pressure	pressure	NN
cord-007726-bqlf72fe	13	26	on	on	IN
cord-007726-bqlf72fe	13	27	respiratory	respiratory	JJ
cord-007726-bqlf72fe	13	28	function	function	NN
cord-007726-bqlf72fe	13	29	[	[	-LRB-
cord-007726-bqlf72fe	13	30	2	2	CD
cord-007726-bqlf72fe	13	31	]	]	-RRB-
cord-007726-bqlf72fe	13	32	.	.	.
cord-007726-bqlf72fe	14	1	More	more	RBR
cord-007726-bqlf72fe	14	2	recently	recently	RB
cord-007726-bqlf72fe	14	3	,	,	,
cord-007726-bqlf72fe	14	4	with	with	IN
cord-007726-bqlf72fe	14	5	data	datum	NNS
cord-007726-bqlf72fe	14	6	from	from	IN
cord-007726-bqlf72fe	14	7	the	the	DT
cord-007726-bqlf72fe	14	8	Human	Human	NNP
cord-007726-bqlf72fe	14	9	Genome	Genome	NNP
cord-007726-bqlf72fe	14	10	Project	Project	NNP
cord-007726-bqlf72fe	14	11	and	and	CC
cord-007726-bqlf72fe	14	12	sequencing	sequencing	NN
cord-007726-bqlf72fe	14	13	of	of	IN
cord-007726-bqlf72fe	14	14	the	the	DT
cord-007726-bqlf72fe	14	15	Mus	Mus	NNP
cord-007726-bqlf72fe	14	16	musculus	musculus	NN
cord-007726-bqlf72fe	14	17	genome	genome	NN
cord-007726-bqlf72fe	14	18	showing	show	VBG
cord-007726-bqlf72fe	14	19	remarkable	remarkable	JJ
cord-007726-bqlf72fe	14	20	genetic	genetic	JJ
cord-007726-bqlf72fe	14	21	homology	homology	NN
cord-007726-bqlf72fe	14	22	between	between	IN
cord-007726-bqlf72fe	14	23	these	these	DT
cord-007726-bqlf72fe	14	24	species	specie	NNS
cord-007726-bqlf72fe	14	25	,	,	,
cord-007726-bqlf72fe	14	26	as	as	RB
cord-007726-bqlf72fe	14	27	well	well	RB
cord-007726-bqlf72fe	14	28	as	as	IN
cord-007726-bqlf72fe	14	29	the	the	DT
cord-007726-bqlf72fe	14	30	advent	advent	NN
cord-007726-bqlf72fe	14	31	of	of	IN
cord-007726-bqlf72fe	14	32	biotechnology	biotechnology	NN
cord-007726-bqlf72fe	14	33	and	and	CC
cord-007726-bqlf72fe	14	34	the	the	DT
cord-007726-bqlf72fe	14	35	development	development	NN
cord-007726-bqlf72fe	14	36	of	of	IN
cord-007726-bqlf72fe	14	37	myriad	myriad	JJ
cord-007726-bqlf72fe	14	38	knockout	knockout	NN
cord-007726-bqlf72fe	14	39	and	and	CC
cord-007726-bqlf72fe	14	40	transgenic	transgenic	JJ
cord-007726-bqlf72fe	14	41	mouse	mouse	NN
cord-007726-bqlf72fe	14	42	strains	strain	NNS
cord-007726-bqlf72fe	14	43	,	,	,
cord-007726-bqlf72fe	14	44	it	-PRON-	PRP
cord-007726-bqlf72fe	14	45	is	be	VBZ
cord-007726-bqlf72fe	14	46	clear	clear	JJ
cord-007726-bqlf72fe	14	47	why	why	WRB
cord-007726-bqlf72fe	14	48	the	the	DT
cord-007726-bqlf72fe	14	49	mouse	mouse	NN
cord-007726-bqlf72fe	14	50	has	have	VBZ
cord-007726-bqlf72fe	14	51	become	become	VBN
cord-007726-bqlf72fe	14	52	the	the	DT
cord-007726-bqlf72fe	14	53	most	most	RBS
cord-007726-bqlf72fe	14	54	ubiquitous	ubiquitous	JJ
cord-007726-bqlf72fe	14	55	model	model	NN
cord-007726-bqlf72fe	14	56	organism	organism	NN
cord-007726-bqlf72fe	14	57	used	use	VBN
cord-007726-bqlf72fe	14	58	to	to	TO
cord-007726-bqlf72fe	14	59	study	study	VB
cord-007726-bqlf72fe	14	60	human	human	JJ
cord-007726-bqlf72fe	14	61	disease	disease	NN
cord-007726-bqlf72fe	14	62	.	.	.
cord-007726-bqlf72fe	15	1	In	in	IN
cord-007726-bqlf72fe	15	2	addition	addition	NN
cord-007726-bqlf72fe	15	3	,	,	,
cord-007726-bqlf72fe	15	4	their	-PRON-	PRP$
cord-007726-bqlf72fe	15	5	small	small	JJ
cord-007726-bqlf72fe	15	6	size	size	NN
cord-007726-bqlf72fe	15	7	,	,	,
cord-007726-bqlf72fe	15	8	rapid	rapid	JJ
cord-007726-bqlf72fe	15	9	breeding	breeding	NN
cord-007726-bqlf72fe	15	10	,	,	,
cord-007726-bqlf72fe	15	11	and	and	CC
cord-007726-bqlf72fe	15	12	ease	ease	NN
cord-007726-bqlf72fe	15	13	of	of	IN
cord-007726-bqlf72fe	15	14	handling	handling	NN
cord-007726-bqlf72fe	15	15	are	be	VBP
cord-007726-bqlf72fe	15	16	all	all	DT
cord-007726-bqlf72fe	15	17	important	important	JJ
cord-007726-bqlf72fe	15	18	advantages	advantage	NNS
cord-007726-bqlf72fe	15	19	to	to	IN
cord-007726-bqlf72fe	15	20	scientists	scientist	NNS
cord-007726-bqlf72fe	15	21	for	for	IN
cord-007726-bqlf72fe	15	22	practical	practical	JJ
cord-007726-bqlf72fe	15	23	and	and	CC
cord-007726-bqlf72fe	15	24	financial	financial	JJ
cord-007726-bqlf72fe	15	25	reasons	reason	NNS
cord-007726-bqlf72fe	15	26	.	.	.
cord-007726-bqlf72fe	16	1	However	however	RB
cord-007726-bqlf72fe	16	2	,	,	,
cord-007726-bqlf72fe	16	3	keeping	keep	VBG
cord-007726-bqlf72fe	16	4	in	in	IN
cord-007726-bqlf72fe	16	5	mind	mind	NN
cord-007726-bqlf72fe	16	6	that	that	IN
cord-007726-bqlf72fe	16	7	mice	mouse	NNS
cord-007726-bqlf72fe	16	8	are	be	VBP
cord-007726-bqlf72fe	16	9	fellow	fellow	JJ
cord-007726-bqlf72fe	16	10	vertebrates	vertebrate	NNS
cord-007726-bqlf72fe	16	11	and	and	CC
cord-007726-bqlf72fe	16	12	mammals	mammal	NNS
cord-007726-bqlf72fe	16	13	,	,	,
cord-007726-bqlf72fe	16	14	there	there	EX
cord-007726-bqlf72fe	16	15	are	be	VBP
cord-007726-bqlf72fe	16	16	ethical	ethical	JJ
cord-007726-bqlf72fe	16	17	issues	issue	NNS
cord-007726-bqlf72fe	16	18	inherent	inherent	JJ
cord-007726-bqlf72fe	16	19	to	to	IN
cord-007726-bqlf72fe	16	20	using	use	VBG
cord-007726-bqlf72fe	16	21	these	these	DT
cord-007726-bqlf72fe	16	22	animals	animal	NNS
cord-007726-bqlf72fe	16	23	in	in	IN
cord-007726-bqlf72fe	16	24	medical	medical	JJ
cord-007726-bqlf72fe	16	25	research	research	NN
cord-007726-bqlf72fe	16	26	.	.	.
cord-007726-bqlf72fe	17	1	This	this	DT
cord-007726-bqlf72fe	17	2	chapter	chapter	NN
cord-007726-bqlf72fe	17	3	will	will	MD
cord-007726-bqlf72fe	17	4	provide	provide	VB
cord-007726-bqlf72fe	17	5	an	an	DT
cord-007726-bqlf72fe	17	6	overview	overview	NN
cord-007726-bqlf72fe	17	7	of	of	IN
cord-007726-bqlf72fe	17	8	the	the	DT
cord-007726-bqlf72fe	17	9	important	important	JJ
cord-007726-bqlf72fe	17	10	similarities	similarity	NNS
cord-007726-bqlf72fe	17	11	and	and	CC
cord-007726-bqlf72fe	17	12	differences	difference	NNS
cord-007726-bqlf72fe	17	13	between	between	IN
cord-007726-bqlf72fe	17	14	Mus	Mus	NNP
cord-007726-bqlf72fe	17	15	musculus	musculus	NN
cord-007726-bqlf72fe	17	16	and	and	CC
cord-007726-bqlf72fe	17	17	Homo	Homo	NNP
cord-007726-bqlf72fe	17	18	sapiens	sapien	NNS
cord-007726-bqlf72fe	17	19	and	and	CC
cord-007726-bqlf72fe	17	20	their	-PRON-	PRP$
cord-007726-bqlf72fe	17	21	relevance	relevance	NN
cord-007726-bqlf72fe	17	22	to	to	IN
cord-007726-bqlf72fe	17	23	the	the	DT
cord-007726-bqlf72fe	17	24	use	use	NN
cord-007726-bqlf72fe	17	25	of	of	IN
cord-007726-bqlf72fe	17	26	the	the	DT
cord-007726-bqlf72fe	17	27	mouse	mouse	NN
cord-007726-bqlf72fe	17	28	as	as	IN
cord-007726-bqlf72fe	17	29	a	a	DT
cord-007726-bqlf72fe	17	30	model	model	NN
cord-007726-bqlf72fe	17	31	organism	organism	NN
cord-007726-bqlf72fe	17	32	and	and	CC
cord-007726-bqlf72fe	17	33	provide	provide	VB
cord-007726-bqlf72fe	17	34	specific	specific	JJ
cord-007726-bqlf72fe	17	35	examples	example	NNS
cord-007726-bqlf72fe	17	36	of	of	IN
cord-007726-bqlf72fe	17	37	the	the	DT
cord-007726-bqlf72fe	17	38	quality	quality	NN
cord-007726-bqlf72fe	17	39	of	of	IN
cord-007726-bqlf72fe	17	40	mouse	mouse	NN
cord-007726-bqlf72fe	17	41	models	model	NNS
cord-007726-bqlf72fe	17	42	used	use	VBN
cord-007726-bqlf72fe	17	43	to	to	TO
cord-007726-bqlf72fe	17	44	investigate	investigate	VB
cord-007726-bqlf72fe	17	45	the	the	DT
cord-007726-bqlf72fe	17	46	mechanisms	mechanism	NNS
cord-007726-bqlf72fe	17	47	,	,	,
cord-007726-bqlf72fe	17	48	pathology	pathology	NN
cord-007726-bqlf72fe	17	49	,	,	,
cord-007726-bqlf72fe	17	50	and	and	CC
cord-007726-bqlf72fe	17	51	treatment	treatment	NN
cord-007726-bqlf72fe	17	52	of	of	IN
cord-007726-bqlf72fe	17	53	human	human	JJ
cord-007726-bqlf72fe	17	54	lung	lung	NN
cord-007726-bqlf72fe	17	55	diseases	disease	NNS
cord-007726-bqlf72fe	17	56	.	.	.
cord-007726-bqlf72fe	18	1	We	-PRON-	PRP
cord-007726-bqlf72fe	18	2	will	will	MD
cord-007726-bqlf72fe	18	3	then	then	RB
cord-007726-bqlf72fe	18	4	conclude	conclude	VB
cord-007726-bqlf72fe	18	5	with	with	IN
cord-007726-bqlf72fe	18	6	an	an	DT
cord-007726-bqlf72fe	18	7	assessment	assessment	NN
cord-007726-bqlf72fe	18	8	of	of	IN
cord-007726-bqlf72fe	18	9	the	the	DT
cord-007726-bqlf72fe	18	10	future	future	NN
cord-007726-bqlf72fe	18	11	of	of	IN
cord-007726-bqlf72fe	18	12	mice	mouse	NNS
cord-007726-bqlf72fe	18	13	in	in	IN
cord-007726-bqlf72fe	18	14	medical	medical	JJ
cord-007726-bqlf72fe	18	15	research	research	NN
cord-007726-bqlf72fe	18	16	considering	consider	VBG
cord-007726-bqlf72fe	18	17	ethical	ethical	JJ
cord-007726-bqlf72fe	18	18	and	and	CC
cord-007726-bqlf72fe	18	19	technological	technological	JJ
cord-007726-bqlf72fe	18	20	advances	advance	NNS
cord-007726-bqlf72fe	18	21	.	.	.
cord-007726-bqlf72fe	19	1	As	as	IN
cord-007726-bqlf72fe	19	2	a	a	DT
cord-007726-bqlf72fe	19	3	model	model	NN
cord-007726-bqlf72fe	19	4	organism	organism	NN
cord-007726-bqlf72fe	19	5	used	use	VBN
cord-007726-bqlf72fe	19	6	to	to	TO
cord-007726-bqlf72fe	19	7	test	test	VB
cord-007726-bqlf72fe	19	8	hypotheses	hypothesis	NNS
cord-007726-bqlf72fe	19	9	and	and	CC
cord-007726-bqlf72fe	19	10	treatments	treatment	NNS
cord-007726-bqlf72fe	19	11	related	relate	VBN
cord-007726-bqlf72fe	19	12	to	to	IN
cord-007726-bqlf72fe	19	13	human	human	JJ
cord-007726-bqlf72fe	19	14	disease	disease	NN
cord-007726-bqlf72fe	19	15	,	,	,
cord-007726-bqlf72fe	19	16	it	-PRON-	PRP
cord-007726-bqlf72fe	19	17	is	be	VBZ
cord-007726-bqlf72fe	19	18	important	important	JJ
cord-007726-bqlf72fe	19	19	to	to	TO
cord-007726-bqlf72fe	19	20	understand	understand	VB
cord-007726-bqlf72fe	19	21	the	the	DT
cord-007726-bqlf72fe	19	22	complex	complex	JJ
cord-007726-bqlf72fe	19	23	ways	way	NNS
cord-007726-bqlf72fe	19	24	in	in	IN
cord-007726-bqlf72fe	19	25	which	which	WDT
cord-007726-bqlf72fe	19	26	mice	mouse	NNS
cord-007726-bqlf72fe	19	27	are	be	VBP
cord-007726-bqlf72fe	19	28	similar	similar	JJ
cord-007726-bqlf72fe	19	29	to	to	IN
cord-007726-bqlf72fe	19	30	humans	human	NNS
cord-007726-bqlf72fe	19	31	,	,	,
cord-007726-bqlf72fe	19	32	and	and	CC
cord-007726-bqlf72fe	19	33	crucially	crucially	RB
cord-007726-bqlf72fe	19	34	,	,	,
cord-007726-bqlf72fe	19	35	the	the	DT
cord-007726-bqlf72fe	19	36	ways	way	NNS
cord-007726-bqlf72fe	19	37	in	in	IN
cord-007726-bqlf72fe	19	38	which	which	WDT
cord-007726-bqlf72fe	19	39	they	-PRON-	PRP
cord-007726-bqlf72fe	19	40	differ	differ	VBP
cord-007726-bqlf72fe	19	41	.	.	.
cord-007726-bqlf72fe	20	1	A	a	DT
cord-007726-bqlf72fe	20	2	clear	clear	JJ
cord-007726-bqlf72fe	20	3	understanding	understanding	NN
cord-007726-bqlf72fe	20	4	of	of	IN
cord-007726-bqlf72fe	20	5	these	these	DT
cord-007726-bqlf72fe	20	6	aspects	aspect	NNS
cord-007726-bqlf72fe	20	7	will	will	MD
cord-007726-bqlf72fe	20	8	allow	allow	VB
cord-007726-bqlf72fe	20	9	researchers	researcher	NNS
cord-007726-bqlf72fe	20	10	to	to	TO
cord-007726-bqlf72fe	20	11	use	use	VB
cord-007726-bqlf72fe	20	12	mouse	mouse	NN
cord-007726-bqlf72fe	20	13	models	model	NNS
cord-007726-bqlf72fe	20	14	of	of	IN
cord-007726-bqlf72fe	20	15	human	human	JJ
cord-007726-bqlf72fe	20	16	disease	disease	NN
cord-007726-bqlf72fe	20	17	and	and	CC
cord-007726-bqlf72fe	20	18	primary	primary	JJ
cord-007726-bqlf72fe	20	19	cells	cell	NNS
cord-007726-bqlf72fe	20	20	derived	derive	VBN
cord-007726-bqlf72fe	20	21	from	from	IN
cord-007726-bqlf72fe	20	22	mice	mouse	NNS
cord-007726-bqlf72fe	20	23	under	under	IN
cord-007726-bqlf72fe	20	24	the	the	DT
cord-007726-bqlf72fe	20	25	most	most	RBS
cord-007726-bqlf72fe	20	26	appropriate	appropriate	JJ
cord-007726-bqlf72fe	20	27	and	and	CC
cord-007726-bqlf72fe	20	28	meaningful	meaningful	JJ
cord-007726-bqlf72fe	20	29	conditions	condition	NNS
cord-007726-bqlf72fe	20	30	.	.	.
cord-007726-bqlf72fe	21	1	In	in	IN
cord-007726-bqlf72fe	21	2	2014	2014	CD
cord-007726-bqlf72fe	21	3	,	,	,
cord-007726-bqlf72fe	21	4	the	the	DT
cord-007726-bqlf72fe	21	5	Encyclopedia	Encyclopedia	NNP
cord-007726-bqlf72fe	21	6	of	of	IN
cord-007726-bqlf72fe	21	7	DNA	DNA	NNP
cord-007726-bqlf72fe	21	8	Elements	Elements	NNP
cord-007726-bqlf72fe	21	9	(	(	-LRB-
cord-007726-bqlf72fe	21	10	ENCODE	encode	VB
cord-007726-bqlf72fe	21	11	)	)	-RRB-
cord-007726-bqlf72fe	21	12	program	program	NN
cord-007726-bqlf72fe	21	13	published	publish	VBD
cord-007726-bqlf72fe	21	14	a	a	DT
cord-007726-bqlf72fe	21	15	comparative	comparative	JJ
cord-007726-bqlf72fe	21	16	analysis	analysis	NN
cord-007726-bqlf72fe	21	17	of	of	IN
cord-007726-bqlf72fe	21	18	the	the	DT
cord-007726-bqlf72fe	21	19	genomes	genome	NNS
cord-007726-bqlf72fe	21	20	of	of	IN
cord-007726-bqlf72fe	21	21	Homo	homo	NN
cord-007726-bqlf72fe	21	22	sapiens	sapiens	JJ
cord-007726-bqlf72fe	21	23	and	and	CC
cord-007726-bqlf72fe	21	24	Mus	mus	NN
cord-007726-bqlf72fe	21	25	musculus	musculus	NN
cord-007726-bqlf72fe	21	26	[	[	-LRB-
cord-007726-bqlf72fe	21	27	3	3	CD
cord-007726-bqlf72fe	21	28	]	]	-RRB-
cord-007726-bqlf72fe	21	29	,	,	,
cord-007726-bqlf72fe	21	30	as	as	RB
cord-007726-bqlf72fe	21	31	well	well	RB
cord-007726-bqlf72fe	21	32	as	as	IN
cord-007726-bqlf72fe	21	33	an	an	DT
cord-007726-bqlf72fe	21	34	in	in	IN
cord-007726-bqlf72fe	21	35	-	-	HYPH
cord-007726-bqlf72fe	21	36	depth	depth	NN
cord-007726-bqlf72fe	21	37	analysis	analysis	NN
cord-007726-bqlf72fe	21	38	of	of	IN
cord-007726-bqlf72fe	21	39	the	the	DT
cord-007726-bqlf72fe	21	40	differences	difference	NNS
cord-007726-bqlf72fe	21	41	in	in	IN
cord-007726-bqlf72fe	21	42	the	the	DT
cord-007726-bqlf72fe	21	43	regulatory	regulatory	JJ
cord-007726-bqlf72fe	21	44	landscape	landscape	NN
cord-007726-bqlf72fe	21	45	of	of	IN
cord-007726-bqlf72fe	21	46	the	the	DT
cord-007726-bqlf72fe	21	47	genomes	genome	NNS
cord-007726-bqlf72fe	21	48	of	of	IN
cord-007726-bqlf72fe	21	49	these	these	DT
cord-007726-bqlf72fe	21	50	species	specie	NNS
cord-007726-bqlf72fe	21	51	[	[	-LRB-
cord-007726-bqlf72fe	21	52	4	4	CD
cord-007726-bqlf72fe	21	53	]	]	-RRB-
cord-007726-bqlf72fe	21	54	.	.	.
cord-007726-bqlf72fe	22	1	ENCODE	encode	VB
cord-007726-bqlf72fe	22	2	,	,	,
cord-007726-bqlf72fe	22	3	a	a	DT
cord-007726-bqlf72fe	22	4	follow	follow	NN
cord-007726-bqlf72fe	22	5	-	-	HYPH
cord-007726-bqlf72fe	22	6	up	up	NN
cord-007726-bqlf72fe	22	7	to	to	IN
cord-007726-bqlf72fe	22	8	the	the	DT
cord-007726-bqlf72fe	22	9	Human	Human	NNP
cord-007726-bqlf72fe	22	10	Genome	Genome	NNP
cord-007726-bqlf72fe	22	11	Project	Project	NNP
cord-007726-bqlf72fe	22	12	,	,	,
cord-007726-bqlf72fe	22	13	was	be	VBD
cord-007726-bqlf72fe	22	14	implemented	implement	VBN
cord-007726-bqlf72fe	22	15	by	by	IN
cord-007726-bqlf72fe	22	16	the	the	DT
cord-007726-bqlf72fe	22	17	National	National	NNP
cord-007726-bqlf72fe	22	18	Human	Human	NNP
cord-007726-bqlf72fe	22	19	Genome	Genome	NNP
cord-007726-bqlf72fe	22	20	Research	Research	NNP
cord-007726-bqlf72fe	22	21	Institute	Institute	NNP
cord-007726-bqlf72fe	22	22	(	(	-LRB-
cord-007726-bqlf72fe	22	23	NHGRI	NHGRI	NNP
cord-007726-bqlf72fe	22	24	)	)	-RRB-
cord-007726-bqlf72fe	22	25	at	at	IN
cord-007726-bqlf72fe	22	26	the	the	DT
cord-007726-bqlf72fe	22	27	National	National	NNP
cord-007726-bqlf72fe	22	28	Institutes	Institutes	NNPS
cord-007726-bqlf72fe	22	29	of	of	IN
cord-007726-bqlf72fe	22	30	Health	Health	NNP
cord-007726-bqlf72fe	22	31	in	in	IN
cord-007726-bqlf72fe	22	32	order	order	NN
cord-007726-bqlf72fe	22	33	to	to	TO
cord-007726-bqlf72fe	22	34	develop	develop	VB
cord-007726-bqlf72fe	22	35	a	a	DT
cord-007726-bqlf72fe	22	36	comprehensive	comprehensive	JJ
cord-007726-bqlf72fe	22	37	catalog	catalog	NN
cord-007726-bqlf72fe	22	38	of	of	IN
cord-007726-bqlf72fe	22	39	protein	protein	NN
cord-007726-bqlf72fe	22	40	-	-	HYPH
cord-007726-bqlf72fe	22	41	encoding	encode	VBG
cord-007726-bqlf72fe	22	42	and	and	CC
cord-007726-bqlf72fe	22	43	nonproteincoding	nonproteincode	VBG
cord-007726-bqlf72fe	22	44	genes	gene	NNS
cord-007726-bqlf72fe	22	45	and	and	CC
cord-007726-bqlf72fe	22	46	the	the	DT
cord-007726-bqlf72fe	22	47	regulatory	regulatory	JJ
cord-007726-bqlf72fe	22	48	elements	element	NNS
cord-007726-bqlf72fe	22	49	that	that	WDT
cord-007726-bqlf72fe	22	50	control	control	VBP
cord-007726-bqlf72fe	22	51	gene	gene	NN
cord-007726-bqlf72fe	22	52	expression	expression	NN
cord-007726-bqlf72fe	22	53	in	in	IN
cord-007726-bqlf72fe	22	54	a	a	DT
cord-007726-bqlf72fe	22	55	number	number	NN
cord-007726-bqlf72fe	22	56	of	of	IN
cord-007726-bqlf72fe	22	57	species	specie	NNS
cord-007726-bqlf72fe	22	58	.	.	.
cord-007726-bqlf72fe	23	1	This	this	DT
cord-007726-bqlf72fe	23	2	was	be	VBD
cord-007726-bqlf72fe	23	3	achieved	achieve	VBN
cord-007726-bqlf72fe	23	4	using	use	VBG
cord-007726-bqlf72fe	23	5	a	a	DT
cord-007726-bqlf72fe	23	6	number	number	NN
cord-007726-bqlf72fe	23	7	of	of	IN
cord-007726-bqlf72fe	23	8	genomic	genomic	JJ
cord-007726-bqlf72fe	23	9	approaches	approach	NNS
cord-007726-bqlf72fe	23	10	(	(	-LRB-
cord-007726-bqlf72fe	23	11	e.g.	e.g.	RB
cord-007726-bqlf72fe	23	12	,	,	,
cord-007726-bqlf72fe	23	13	RNA	RNA	NNP
cord-007726-bqlf72fe	23	14	-	-	HYPH
cord-007726-bqlf72fe	23	15	seq	seq	NNP
cord-007726-bqlf72fe	23	16	,	,	,
cord-007726-bqlf72fe	23	17	DNase	DNase	NNP
cord-007726-bqlf72fe	23	18	-	-	HYPH
cord-007726-bqlf72fe	23	19	seq	seq	NN
cord-007726-bqlf72fe	23	20	,	,	,
cord-007726-bqlf72fe	23	21	and	and	CC
cord-007726-bqlf72fe	23	22	ChIP	chip	NN
cord-007726-bqlf72fe	23	23	-	-	HYPH
cord-007726-bqlf72fe	23	24	seq	seq	NNP
cord-007726-bqlf72fe	23	25	)	)	-RRB-
cord-007726-bqlf72fe	23	26	to	to	TO
cord-007726-bqlf72fe	23	27	assess	assess	VB
cord-007726-bqlf72fe	23	28	gene	gene	NN
cord-007726-bqlf72fe	23	29	expression	expression	NN
cord-007726-bqlf72fe	23	30	in	in	IN
cord-007726-bqlf72fe	23	31	over	over	IN
cord-007726-bqlf72fe	23	32	100	100	CD
cord-007726-bqlf72fe	23	33	mouse	mouse	NN
cord-007726-bqlf72fe	23	34	cell	cell	NN
cord-007726-bqlf72fe	23	35	types	type	NNS
cord-007726-bqlf72fe	23	36	and	and	CC
cord-007726-bqlf72fe	23	37	tissues	tissue	NNS
cord-007726-bqlf72fe	23	38	;	;	:
cord-007726-bqlf72fe	23	39	the	the	DT
cord-007726-bqlf72fe	23	40	data	datum	NNS
cord-007726-bqlf72fe	23	41	were	be	VBD
cord-007726-bqlf72fe	23	42	then	then	RB
cord-007726-bqlf72fe	23	43	compared	compare	VBN
cord-007726-bqlf72fe	23	44	with	with	IN
cord-007726-bqlf72fe	23	45	the	the	DT
cord-007726-bqlf72fe	23	46	human	human	JJ
cord-007726-bqlf72fe	23	47	genome	genome	NN
cord-007726-bqlf72fe	23	48	.	.	.
cord-007726-bqlf72fe	24	1	Overall	overall	RB
cord-007726-bqlf72fe	24	2	,	,	,
cord-007726-bqlf72fe	24	3	these	these	DT
cord-007726-bqlf72fe	24	4	studies	study	NNS
cord-007726-bqlf72fe	24	5	showed	show	VBD
cord-007726-bqlf72fe	24	6	that	that	IN
cord-007726-bqlf72fe	24	7	although	although	IN
cord-007726-bqlf72fe	24	8	gene	gene	NN
cord-007726-bqlf72fe	24	9	expression	expression	NN
cord-007726-bqlf72fe	24	10	is	be	VBZ
cord-007726-bqlf72fe	24	11	fairly	fairly	RB
cord-007726-bqlf72fe	24	12	similar	similar	JJ
cord-007726-bqlf72fe	24	13	between	between	IN
cord-007726-bqlf72fe	24	14	mice	mouse	NNS
cord-007726-bqlf72fe	24	15	and	and	CC
cord-007726-bqlf72fe	24	16	humans	human	NNS
cord-007726-bqlf72fe	24	17	,	,	,
cord-007726-bqlf72fe	24	18	considerable	considerable	JJ
cord-007726-bqlf72fe	24	19	differences	difference	NNS
cord-007726-bqlf72fe	24	20	were	be	VBD
cord-007726-bqlf72fe	24	21	observed	observe	VBN
cord-007726-bqlf72fe	24	22	in	in	IN
cord-007726-bqlf72fe	24	23	the	the	DT
cord-007726-bqlf72fe	24	24	regulatory	regulatory	JJ
cord-007726-bqlf72fe	24	25	networks	network	NNS
cord-007726-bqlf72fe	24	26	controlling	control	VBG
cord-007726-bqlf72fe	24	27	the	the	DT
cord-007726-bqlf72fe	24	28	activity	activity	NN
cord-007726-bqlf72fe	24	29	of	of	IN
cord-007726-bqlf72fe	24	30	the	the	DT
cord-007726-bqlf72fe	24	31	immune	immune	JJ
cord-007726-bqlf72fe	24	32	system	system	NN
cord-007726-bqlf72fe	24	33	,	,	,
cord-007726-bqlf72fe	24	34	metabolic	metabolic	JJ
cord-007726-bqlf72fe	24	35	functions	function	NNS
cord-007726-bqlf72fe	24	36	,	,	,
cord-007726-bqlf72fe	24	37	and	and	CC
cord-007726-bqlf72fe	24	38	responses	response	NNS
cord-007726-bqlf72fe	24	39	to	to	TO
cord-007726-bqlf72fe	24	40	stress	stress	VB
cord-007726-bqlf72fe	24	41	,	,	,
cord-007726-bqlf72fe	24	42	all	all	DT
cord-007726-bqlf72fe	24	43	of	of	IN
cord-007726-bqlf72fe	24	44	which	which	WDT
cord-007726-bqlf72fe	24	45	have	have	VBP
cord-007726-bqlf72fe	24	46	important	important	JJ
cord-007726-bqlf72fe	24	47	implications	implication	NNS
cord-007726-bqlf72fe	24	48	when	when	WRB
cord-007726-bqlf72fe	24	49	using	use	VBG
cord-007726-bqlf72fe	24	50	mice	mouse	NNS
cord-007726-bqlf72fe	24	51	to	to	TO
cord-007726-bqlf72fe	24	52	model	model	VB
cord-007726-bqlf72fe	24	53	human	human	JJ
cord-007726-bqlf72fe	24	54	disease	disease	NN
cord-007726-bqlf72fe	24	55	.	.	.
cord-007726-bqlf72fe	25	1	In	in	IN
cord-007726-bqlf72fe	25	2	essence	essence	NN
cord-007726-bqlf72fe	25	3	,	,	,
cord-007726-bqlf72fe	25	4	mice	mouse	NNS
cord-007726-bqlf72fe	25	5	and	and	CC
cord-007726-bqlf72fe	25	6	humans	human	NNS
cord-007726-bqlf72fe	25	7	demonstrate	demonstrate	VBP
cord-007726-bqlf72fe	25	8	genetic	genetic	JJ
cord-007726-bqlf72fe	25	9	similarity	similarity	NN
cord-007726-bqlf72fe	25	10	with	with	IN
cord-007726-bqlf72fe	25	11	regulatory	regulatory	JJ
cord-007726-bqlf72fe	25	12	divergence	divergence	NN
cord-007726-bqlf72fe	25	13	.	.	.
cord-007726-bqlf72fe	26	1	Specifically	specifically	RB
cord-007726-bqlf72fe	26	2	,	,	,
cord-007726-bqlf72fe	26	3	there	there	EX
cord-007726-bqlf72fe	26	4	is	be	VBZ
cord-007726-bqlf72fe	26	5	a	a	DT
cord-007726-bqlf72fe	26	6	high	high	JJ
cord-007726-bqlf72fe	26	7	degree	degree	NN
cord-007726-bqlf72fe	26	8	of	of	IN
cord-007726-bqlf72fe	26	9	similarity	similarity	NN
cord-007726-bqlf72fe	26	10	in	in	IN
cord-007726-bqlf72fe	26	11	transcription	transcription	NN
cord-007726-bqlf72fe	26	12	factor	factor	NN
cord-007726-bqlf72fe	26	13	networks	network	NNS
cord-007726-bqlf72fe	26	14	but	but	CC
cord-007726-bqlf72fe	26	15	a	a	DT
cord-007726-bqlf72fe	26	16	great	great	JJ
cord-007726-bqlf72fe	26	17	deal	deal	NN
cord-007726-bqlf72fe	26	18	of	of	IN
cord-007726-bqlf72fe	26	19	divergence	divergence	NN
cord-007726-bqlf72fe	26	20	in	in	IN
cord-007726-bqlf72fe	26	21	the	the	DT
cord-007726-bqlf72fe	26	22	cis	cis	JJ
cord-007726-bqlf72fe	26	23	-	-	HYPH
cord-007726-bqlf72fe	26	24	regulatory	regulatory	JJ
cord-007726-bqlf72fe	26	25	elements	element	NNS
cord-007726-bqlf72fe	26	26	that	that	WDT
cord-007726-bqlf72fe	26	27	control	control	VBP
cord-007726-bqlf72fe	26	28	gene	gene	NN
cord-007726-bqlf72fe	26	29	transcription	transcription	NN
cord-007726-bqlf72fe	26	30	in	in	IN
cord-007726-bqlf72fe	26	31	the	the	DT
cord-007726-bqlf72fe	26	32	mouse	mouse	NN
cord-007726-bqlf72fe	26	33	and	and	CC
cord-007726-bqlf72fe	26	34	human	human	JJ
cord-007726-bqlf72fe	26	35	genomes	genome	NNS
cord-007726-bqlf72fe	26	36	.	.	.
cord-007726-bqlf72fe	27	1	Moreover	moreover	RB
cord-007726-bqlf72fe	27	2	,	,	,
cord-007726-bqlf72fe	27	3	the	the	DT
cord-007726-bqlf72fe	27	4	chromatin	chromatin	NN
cord-007726-bqlf72fe	27	5	landscape	landscape	NN
cord-007726-bqlf72fe	27	6	in	in	IN
cord-007726-bqlf72fe	27	7	cell	cell	NN
cord-007726-bqlf72fe	27	8	types	type	NNS
cord-007726-bqlf72fe	27	9	of	of	IN
cord-007726-bqlf72fe	27	10	similar	similar	JJ
cord-007726-bqlf72fe	27	11	lineages	lineage	NNS
cord-007726-bqlf72fe	27	12	in	in	IN
cord-007726-bqlf72fe	27	13	mouse	mouse	NN
cord-007726-bqlf72fe	27	14	and	and	CC
cord-007726-bqlf72fe	27	15	human	human	NN
cord-007726-bqlf72fe	27	16	is	be	VBZ
cord-007726-bqlf72fe	27	17	both	both	DT
cord-007726-bqlf72fe	27	18	developmentally	developmentally	RB
cord-007726-bqlf72fe	27	19	stable	stable	JJ
cord-007726-bqlf72fe	27	20	and	and	CC
cord-007726-bqlf72fe	27	21	evolutionarily	evolutionarily	RB
cord-007726-bqlf72fe	27	22	conserved	conserved	JJ
cord-007726-bqlf72fe	27	23	[	[	-LRB-
cord-007726-bqlf72fe	27	24	3	3	CD
cord-007726-bqlf72fe	27	25	]	]	-RRB-
cord-007726-bqlf72fe	27	26	.	.	.
cord-007726-bqlf72fe	28	1	Of	of	IN
cord-007726-bqlf72fe	28	2	particular	particular	JJ
cord-007726-bqlf72fe	28	3	relevance	relevance	NN
cord-007726-bqlf72fe	28	4	regarding	regard	VBG
cord-007726-bqlf72fe	28	5	modeling	model	VBG
cord-007726-bqlf72fe	28	6	human	human	JJ
cord-007726-bqlf72fe	28	7	diseases	disease	NNS
cord-007726-bqlf72fe	28	8	involving	involve	VBG
cord-007726-bqlf72fe	28	9	the	the	DT
cord-007726-bqlf72fe	28	10	immune	immune	JJ
cord-007726-bqlf72fe	28	11	system	system	NN
cord-007726-bqlf72fe	28	12	,	,	,
cord-007726-bqlf72fe	28	13	in	in	IN
cord-007726-bqlf72fe	28	14	its	-PRON-	PRP$
cord-007726-bqlf72fe	28	15	assessment	assessment	NN
cord-007726-bqlf72fe	28	16	of	of	IN
cord-007726-bqlf72fe	28	17	transcription	transcription	NN
cord-007726-bqlf72fe	28	18	factor	factor	NN
cord-007726-bqlf72fe	28	19	networks	network	NNS
cord-007726-bqlf72fe	28	20	,	,	,
cord-007726-bqlf72fe	28	21	the	the	DT
cord-007726-bqlf72fe	28	22	Mouse	Mouse	NNP
cord-007726-bqlf72fe	28	23	ENCODE	ENCODE	NNP
cord-007726-bqlf72fe	28	24	Consortium	Consortium	NNP
cord-007726-bqlf72fe	28	25	revealed	reveal	VBD
cord-007726-bqlf72fe	28	26	potentially	potentially	RB
cord-007726-bqlf72fe	28	27	important	important	JJ
cord-007726-bqlf72fe	28	28	differences	difference	NNS
cord-007726-bqlf72fe	28	29	in	in	IN
cord-007726-bqlf72fe	28	30	the	the	DT
cord-007726-bqlf72fe	28	31	activity	activity	NN
cord-007726-bqlf72fe	28	32	of	of	IN
cord-007726-bqlf72fe	28	33	ETS1	ETS1	NNP
cord-007726-bqlf72fe	28	34	in	in	IN
cord-007726-bqlf72fe	28	35	the	the	DT
cord-007726-bqlf72fe	28	36	mouse	mouse	NN
cord-007726-bqlf72fe	28	37	and	and	CC
cord-007726-bqlf72fe	28	38	human	human	JJ
cord-007726-bqlf72fe	28	39	genome	genome	NN
cord-007726-bqlf72fe	28	40	.	.	.
cord-007726-bqlf72fe	29	1	Although	although	IN
cord-007726-bqlf72fe	29	2	conserved	conserve	VBN
cord-007726-bqlf72fe	29	3	between	between	IN
cord-007726-bqlf72fe	29	4	the	the	DT
cord-007726-bqlf72fe	29	5	two	two	CD
cord-007726-bqlf72fe	29	6	species	specie	NNS
cord-007726-bqlf72fe	29	7	,	,	,
cord-007726-bqlf72fe	29	8	divergence	divergence	NN
cord-007726-bqlf72fe	29	9	in	in	IN
cord-007726-bqlf72fe	29	10	ETS1	ETS1	NNP
cord-007726-bqlf72fe	29	11	regulation	regulation	NN
cord-007726-bqlf72fe	29	12	may	may	MD
cord-007726-bqlf72fe	29	13	be	be	VB
cord-007726-bqlf72fe	29	14	responsible	responsible	JJ
cord-007726-bqlf72fe	29	15	for	for	IN
cord-007726-bqlf72fe	29	16	discrepancies	discrepancy	NNS
cord-007726-bqlf72fe	29	17	in	in	IN
cord-007726-bqlf72fe	29	18	the	the	DT
cord-007726-bqlf72fe	29	19	function	function	NN
cord-007726-bqlf72fe	29	20	of	of	IN
cord-007726-bqlf72fe	29	21	the	the	DT
cord-007726-bqlf72fe	29	22	immune	immune	JJ
cord-007726-bqlf72fe	29	23	system	system	NN
cord-007726-bqlf72fe	29	24	in	in	IN
cord-007726-bqlf72fe	29	25	mouse	mouse	NN
cord-007726-bqlf72fe	29	26	and	and	CC
cord-007726-bqlf72fe	29	27	human	human	NN
cord-007726-bqlf72fe	29	28	[	[	-LRB-
cord-007726-bqlf72fe	29	29	4	4	CD
cord-007726-bqlf72fe	29	30	]	]	-RRB-
cord-007726-bqlf72fe	29	31	.	.	.
cord-007726-bqlf72fe	30	1	Certainly	certainly	RB
cord-007726-bqlf72fe	30	2	,	,	,
cord-007726-bqlf72fe	30	3	the	the	DT
cord-007726-bqlf72fe	30	4	biological	biological	JJ
cord-007726-bqlf72fe	30	5	consequences	consequence	NNS
cord-007726-bqlf72fe	30	6	of	of	IN
cord-007726-bqlf72fe	30	7	these	these	DT
cord-007726-bqlf72fe	30	8	differences	difference	NNS
cord-007726-bqlf72fe	30	9	in	in	IN
cord-007726-bqlf72fe	30	10	gene	gene	NN
cord-007726-bqlf72fe	30	11	expression	expression	NN
cord-007726-bqlf72fe	30	12	and	and	CC
cord-007726-bqlf72fe	30	13	regulation	regulation	NN
cord-007726-bqlf72fe	30	14	between	between	IN
cord-007726-bqlf72fe	30	15	human	human	NN
cord-007726-bqlf72fe	30	16	and	and	CC
cord-007726-bqlf72fe	30	17	mouse	mouse	NN
cord-007726-bqlf72fe	30	18	invite	invite	VB
cord-007726-bqlf72fe	30	19	further	further	JJ
cord-007726-bqlf72fe	30	20	investigation	investigation	NN
cord-007726-bqlf72fe	30	21	.	.	.
cord-007726-bqlf72fe	31	1	The	the	DT
cord-007726-bqlf72fe	31	2	anatomical	anatomical	JJ
cord-007726-bqlf72fe	31	3	and	and	CC
cord-007726-bqlf72fe	31	4	physiological	physiological	JJ
cord-007726-bqlf72fe	31	5	differences	difference	NNS
cord-007726-bqlf72fe	31	6	between	between	IN
cord-007726-bqlf72fe	31	7	model	model	NN
cord-007726-bqlf72fe	31	8	organisms	organism	NNS
cord-007726-bqlf72fe	31	9	and	and	CC
cord-007726-bqlf72fe	31	10	humans	human	NNS
cord-007726-bqlf72fe	31	11	can	can	MD
cord-007726-bqlf72fe	31	12	have	have	VB
cord-007726-bqlf72fe	31	13	profound	profound	JJ
cord-007726-bqlf72fe	31	14	impacts	impact	NNS
cord-007726-bqlf72fe	31	15	on	on	IN
cord-007726-bqlf72fe	31	16	interpreting	interpret	VBG
cord-007726-bqlf72fe	31	17	experimental	experimental	JJ
cord-007726-bqlf72fe	31	18	results	result	NNS
cord-007726-bqlf72fe	31	19	.	.	.
cord-007726-bqlf72fe	32	1	Virtually	virtually	RB
cord-007726-bqlf72fe	32	2	every	every	DT
cord-007726-bqlf72fe	32	3	biological	biological	JJ
cord-007726-bqlf72fe	32	4	process	process	NN
cord-007726-bqlf72fe	32	5	under	under	IN
cord-007726-bqlf72fe	32	6	investigation	investigation	NN
cord-007726-bqlf72fe	32	7	in	in	IN
cord-007726-bqlf72fe	32	8	experimental	experimental	JJ
cord-007726-bqlf72fe	32	9	studies	study	NNS
cord-007726-bqlf72fe	32	10	involves	involve	VBZ
cord-007726-bqlf72fe	32	11	at	at	IN
cord-007726-bqlf72fe	32	12	least	least	RBS
cord-007726-bqlf72fe	32	13	one	one	CD
cord-007726-bqlf72fe	32	14	anatomical	anatomical	JJ
cord-007726-bqlf72fe	32	15	structure	structure	NN
cord-007726-bqlf72fe	32	16	.	.	.
cord-007726-bqlf72fe	33	1	To	to	TO
cord-007726-bqlf72fe	33	2	aid	aid	VB
cord-007726-bqlf72fe	33	3	in	in	IN
cord-007726-bqlf72fe	33	4	interpretation	interpretation	NN
cord-007726-bqlf72fe	33	5	,	,	,
cord-007726-bqlf72fe	33	6	many	many	JJ
cord-007726-bqlf72fe	33	7	anatomy	anatomy	NN
cord-007726-bqlf72fe	33	8	compendia	compendia	NNS
cord-007726-bqlf72fe	33	9	have	have	VBP
cord-007726-bqlf72fe	33	10	been	be	VBN
cord-007726-bqlf72fe	33	11	developed	develop	VBN
cord-007726-bqlf72fe	33	12	for	for	IN
cord-007726-bqlf72fe	33	13	model	model	NN
cord-007726-bqlf72fe	33	14	organisms	organism	NNS
cord-007726-bqlf72fe	33	15	;	;	.
cord-007726-bqlf72fe	34	1	the	the	DT
cord-007726-bqlf72fe	34	2	most	most	RBS
cord-007726-bqlf72fe	34	3	useful	useful	JJ
cord-007726-bqlf72fe	34	4	organize	organize	VB
cord-007726-bqlf72fe	34	5	anatomical	anatomical	JJ
cord-007726-bqlf72fe	34	6	entities	entity	NNS
cord-007726-bqlf72fe	34	7	into	into	IN
cord-007726-bqlf72fe	34	8	hierarchies	hierarchy	NNS
cord-007726-bqlf72fe	34	9	representing	represent	VBG
cord-007726-bqlf72fe	34	10	the	the	DT
cord-007726-bqlf72fe	34	11	structure	structure	NN
cord-007726-bqlf72fe	34	12	of	of	IN
cord-007726-bqlf72fe	34	13	the	the	DT
cord-007726-bqlf72fe	34	14	human	human	JJ
cord-007726-bqlf72fe	34	15	body	body	NN
cord-007726-bqlf72fe	34	16	,	,	,
cord-007726-bqlf72fe	34	17	e.g.	e.g.	RB
cord-007726-bqlf72fe	34	18	,	,	,
cord-007726-bqlf72fe	34	19	the	the	DT
cord-007726-bqlf72fe	34	20	Foundational	Foundational	NNP
cord-007726-bqlf72fe	34	21	Model	Model	NNP
cord-007726-bqlf72fe	34	22	of	of	IN
cord-007726-bqlf72fe	34	23	Anatomy	Anatomy	NNP
cord-007726-bqlf72fe	34	24	developed	develop	VBN
cord-007726-bqlf72fe	34	25	by	by	IN
cord-007726-bqlf72fe	34	26	the	the	DT
cord-007726-bqlf72fe	34	27	Structural	Structural	NNP
cord-007726-bqlf72fe	34	28	Informatics	Informatics	NNP
cord-007726-bqlf72fe	34	29	Group	Group	NNP
cord-007726-bqlf72fe	34	30	at	at	IN
cord-007726-bqlf72fe	34	31	the	the	DT
cord-007726-bqlf72fe	34	32	University	University	NNP
cord-007726-bqlf72fe	34	33	of	of	IN
cord-007726-bqlf72fe	34	34	Washington	Washington	NNP
cord-007726-bqlf72fe	34	35	[	[	-LRB-
cord-007726-bqlf72fe	34	36	5	5	CD
cord-007726-bqlf72fe	34	37	]	]	-RRB-
cord-007726-bqlf72fe	34	38	.	.	.
cord-007726-bqlf72fe	35	1	Although	although	IN
cord-007726-bqlf72fe	35	2	an	an	DT
cord-007726-bqlf72fe	35	3	analysis	analysis	NN
cord-007726-bqlf72fe	35	4	of	of	IN
cord-007726-bqlf72fe	35	5	the	the	DT
cord-007726-bqlf72fe	35	6	myriad	myriad	JJ
cord-007726-bqlf72fe	35	7	differences	difference	NNS
cord-007726-bqlf72fe	35	8	between	between	IN
cord-007726-bqlf72fe	35	9	mouse	mouse	NN
cord-007726-bqlf72fe	35	10	and	and	CC
cord-007726-bqlf72fe	35	11	human	human	JJ
cord-007726-bqlf72fe	35	12	anatomy	anatomy	NN
cord-007726-bqlf72fe	35	13	is	be	VBZ
cord-007726-bqlf72fe	35	14	beyond	beyond	IN
cord-007726-bqlf72fe	35	15	the	the	DT
cord-007726-bqlf72fe	35	16	scope	scope	NN
cord-007726-bqlf72fe	35	17	of	of	IN
cord-007726-bqlf72fe	35	18	this	this	DT
cord-007726-bqlf72fe	35	19	chapter	chapter	NN
cord-007726-bqlf72fe	35	20	,	,	,
cord-007726-bqlf72fe	35	21	a	a	DT
cord-007726-bqlf72fe	35	22	few	few	JJ
cord-007726-bqlf72fe	35	23	of	of	IN
cord-007726-bqlf72fe	35	24	the	the	DT
cord-007726-bqlf72fe	35	25	most	most	RBS
cord-007726-bqlf72fe	35	26	critical	critical	JJ
cord-007726-bqlf72fe	35	27	issues	issue	NNS
cord-007726-bqlf72fe	35	28	that	that	WDT
cord-007726-bqlf72fe	35	29	have	have	VBP
cord-007726-bqlf72fe	35	30	an	an	DT
cord-007726-bqlf72fe	35	31	impact	impact	NN
cord-007726-bqlf72fe	35	32	on	on	IN
cord-007726-bqlf72fe	35	33	the	the	DT
cord-007726-bqlf72fe	35	34	interpretation	interpretation	NN
cord-007726-bqlf72fe	35	35	of	of	IN
cord-007726-bqlf72fe	35	36	data	datum	NNS
cord-007726-bqlf72fe	35	37	from	from	IN
cord-007726-bqlf72fe	35	38	mouse	mouse	NN
cord-007726-bqlf72fe	35	39	experiments	experiment	NNS
cord-007726-bqlf72fe	35	40	should	should	MD
cord-007726-bqlf72fe	35	41	be	be	VB
cord-007726-bqlf72fe	35	42	mentioned	mention	VBN
cord-007726-bqlf72fe	35	43	.	.	.
cord-007726-bqlf72fe	36	1	The	the	DT
cord-007726-bqlf72fe	36	2	most	most	RBS
cord-007726-bqlf72fe	36	3	obvious	obvious	JJ
cord-007726-bqlf72fe	36	4	difference	difference	NN
cord-007726-bqlf72fe	36	5	between	between	IN
cord-007726-bqlf72fe	36	6	mice	mouse	NNS
cord-007726-bqlf72fe	36	7	and	and	CC
cord-007726-bqlf72fe	36	8	humans	human	NNS
cord-007726-bqlf72fe	36	9	is	be	VBZ
cord-007726-bqlf72fe	36	10	size	size	NN
cord-007726-bqlf72fe	36	11	;	;	:
cord-007726-bqlf72fe	36	12	the	the	DT
cord-007726-bqlf72fe	36	13	human	human	JJ
cord-007726-bqlf72fe	36	14	body	body	NN
cord-007726-bqlf72fe	36	15	is	be	VBZ
cord-007726-bqlf72fe	36	16	about	about	IN
cord-007726-bqlf72fe	36	17	2500	2500	CD
cord-007726-bqlf72fe	36	18	times	time	NNS
cord-007726-bqlf72fe	36	19	larger	large	JJR
cord-007726-bqlf72fe	36	20	than	than	IN
cord-007726-bqlf72fe	36	21	that	that	DT
cord-007726-bqlf72fe	36	22	of	of	IN
cord-007726-bqlf72fe	36	23	the	the	DT
cord-007726-bqlf72fe	36	24	mouse	mouse	NN
cord-007726-bqlf72fe	36	25	.	.	.
cord-007726-bqlf72fe	37	1	Size	size	NN
cord-007726-bqlf72fe	37	2	influences	influence	VBZ
cord-007726-bqlf72fe	37	3	many	many	JJ
cord-007726-bqlf72fe	37	4	aspects	aspect	NNS
cord-007726-bqlf72fe	37	5	of	of	IN
cord-007726-bqlf72fe	37	6	biology	biology	NN
cord-007726-bqlf72fe	37	7	,	,	,
cord-007726-bqlf72fe	37	8	particularly	particularly	RB
cord-007726-bqlf72fe	37	9	the	the	DT
cord-007726-bqlf72fe	37	10	metabolic	metabolic	JJ
cord-007726-bqlf72fe	37	11	rate	rate	NN
cord-007726-bqlf72fe	37	12	,	,	,
cord-007726-bqlf72fe	37	13	which	which	WDT
cord-007726-bqlf72fe	37	14	is	be	VBZ
cord-007726-bqlf72fe	37	15	correlated	correlate	VBN
cord-007726-bqlf72fe	37	16	to	to	IN
cord-007726-bqlf72fe	37	17	body	body	NN
cord-007726-bqlf72fe	37	18	size	size	NN
cord-007726-bqlf72fe	37	19	in	in	IN
cord-007726-bqlf72fe	37	20	placental	placental	JJ
cord-007726-bqlf72fe	37	21	mammals	mammal	NNS
cord-007726-bqlf72fe	37	22	through	through	IN
cord-007726-bqlf72fe	37	23	the	the	DT
cord-007726-bqlf72fe	37	24	relationship	relationship	NN
cord-007726-bqlf72fe	37	25	BMR	BMR	NNP
cord-007726-bqlf72fe	37	26	¼	¼	CD
cord-007726-bqlf72fe	37	27	70	70	CD
cord-007726-bqlf72fe	38	1	Â	â	LS
cord-007726-bqlf72fe	38	2	mass	mass	NN
cord-007726-bqlf72fe	38	3	(	(	-LRB-
cord-007726-bqlf72fe	38	4	0.75	0.75	CD
cord-007726-bqlf72fe	38	5	)	)	-RRB-
cord-007726-bqlf72fe	38	6	,	,	,
cord-007726-bqlf72fe	38	7	where	where	WRB
cord-007726-bqlf72fe	38	8	BMR	BMR	NNP
cord-007726-bqlf72fe	38	9	is	be	VBZ
cord-007726-bqlf72fe	38	10	the	the	DT
cord-007726-bqlf72fe	38	11	basal	basal	NN
cord-007726-bqlf72fe	38	12	metabolic	metabolic	JJ
cord-007726-bqlf72fe	38	13	rate	rate	NN
cord-007726-bqlf72fe	38	14	(	(	-LRB-
cord-007726-bqlf72fe	38	15	in	in	IN
cord-007726-bqlf72fe	38	16	kcal	kcal	NNP
cord-007726-bqlf72fe	38	17	/	/	SYM
cord-007726-bqlf72fe	38	18	day	day	NN
cord-007726-bqlf72fe	38	19	)	)	-RRB-
cord-007726-bqlf72fe	38	20	.	.	.
cord-007726-bqlf72fe	39	1	Thus	thus	RB
cord-007726-bqlf72fe	39	2	,	,	,
cord-007726-bqlf72fe	39	3	the	the	DT
cord-007726-bqlf72fe	39	4	mouse	mouse	NN
cord-007726-bqlf72fe	39	5	BMR	BMR	NNP
cord-007726-bqlf72fe	39	6	is	be	VBZ
cord-007726-bqlf72fe	39	7	roughly	roughly	RB
cord-007726-bqlf72fe	39	8	seven	seven	CD
cord-007726-bqlf72fe	39	9	times	time	NNS
cord-007726-bqlf72fe	39	10	faster	fast	RBR
cord-007726-bqlf72fe	39	11	than	than	IN
cord-007726-bqlf72fe	39	12	that	that	DT
cord-007726-bqlf72fe	39	13	of	of	IN
cord-007726-bqlf72fe	39	14	an	an	DT
cord-007726-bqlf72fe	39	15	average	average	JJ
cord-007726-bqlf72fe	39	16	-	-	HYPH
cord-007726-bqlf72fe	39	17	sized	sized	JJ
cord-007726-bqlf72fe	39	18	human	human	JJ
cord-007726-bqlf72fe	39	19	[	[	-LRB-
cord-007726-bqlf72fe	39	20	6	6	CD
cord-007726-bqlf72fe	39	21	]	]	-RRB-
cord-007726-bqlf72fe	39	22	.	.	.
cord-007726-bqlf72fe	40	1	This	this	DT
cord-007726-bqlf72fe	40	2	higher	high	JJR
cord-007726-bqlf72fe	40	3	BMR	BMR	NNP
cord-007726-bqlf72fe	40	4	has	have	VBZ
cord-007726-bqlf72fe	40	5	effects	effect	NNS
cord-007726-bqlf72fe	40	6	on	on	IN
cord-007726-bqlf72fe	40	7	thermoregulation	thermoregulation	NN
cord-007726-bqlf72fe	40	8	,	,	,
cord-007726-bqlf72fe	40	9	nutrient	nutrient	NN
cord-007726-bqlf72fe	40	10	demand	demand	NN
cord-007726-bqlf72fe	40	11	,	,	,
cord-007726-bqlf72fe	40	12	and	and	CC
cord-007726-bqlf72fe	40	13	nutrient	nutrient	NN
cord-007726-bqlf72fe	40	14	supply	supply	NN
cord-007726-bqlf72fe	40	15	.	.	.
cord-007726-bqlf72fe	41	1	As	as	IN
cord-007726-bqlf72fe	41	2	such	such	JJ
cord-007726-bqlf72fe	41	3	,	,	,
cord-007726-bqlf72fe	41	4	mice	mouse	NNS
cord-007726-bqlf72fe	41	5	have	have	VBP
cord-007726-bqlf72fe	41	6	greater	great	JJR
cord-007726-bqlf72fe	41	7	amounts	amount	NNS
cord-007726-bqlf72fe	41	8	of	of	IN
cord-007726-bqlf72fe	41	9	metabolically	metabolically	RB
cord-007726-bqlf72fe	41	10	active	active	JJ
cord-007726-bqlf72fe	41	11	tissues	tissue	NNS
cord-007726-bqlf72fe	41	12	(	(	-LRB-
cord-007726-bqlf72fe	41	13	e.g.	e.g.	RB
cord-007726-bqlf72fe	41	14	,	,	,
cord-007726-bqlf72fe	41	15	liver	liver	NN
cord-007726-bqlf72fe	41	16	and	and	CC
cord-007726-bqlf72fe	41	17	kidney	kidney	NN
cord-007726-bqlf72fe	41	18	)	)	-RRB-
cord-007726-bqlf72fe	41	19	and	and	CC
cord-007726-bqlf72fe	41	20	more	more	RBR
cord-007726-bqlf72fe	41	21	extensive	extensive	JJ
cord-007726-bqlf72fe	41	22	deposits	deposit	NNS
cord-007726-bqlf72fe	41	23	of	of	IN
cord-007726-bqlf72fe	41	24	brown	brown	JJ
cord-007726-bqlf72fe	41	25	fat	fat	NN
cord-007726-bqlf72fe	41	26	[	[	-LRB-
cord-007726-bqlf72fe	41	27	6	6	CD
cord-007726-bqlf72fe	41	28	]	]	-RRB-
cord-007726-bqlf72fe	41	29	.	.	.
cord-007726-bqlf72fe	42	1	Furthermore	furthermore	RB
cord-007726-bqlf72fe	42	2	,	,	,
cord-007726-bqlf72fe	42	3	mice	mouse	NNS
cord-007726-bqlf72fe	42	4	more	more	RBR
cord-007726-bqlf72fe	42	5	readily	readily	RB
cord-007726-bqlf72fe	42	6	produce	produce	VBP
cord-007726-bqlf72fe	42	7	reactive	reactive	JJ
cord-007726-bqlf72fe	42	8	oxygen	oxygen	NN
cord-007726-bqlf72fe	42	9	species	specie	NNS
cord-007726-bqlf72fe	42	10	than	than	IN
cord-007726-bqlf72fe	42	11	do	do	VB
cord-007726-bqlf72fe	42	12	humans	human	NNS
cord-007726-bqlf72fe	42	13	,	,	,
cord-007726-bqlf72fe	42	14	which	which	WDT
cord-007726-bqlf72fe	42	15	is	be	VBZ
cord-007726-bqlf72fe	42	16	an	an	DT
cord-007726-bqlf72fe	42	17	important	important	JJ
cord-007726-bqlf72fe	42	18	consideration	consideration	NN
cord-007726-bqlf72fe	42	19	when	when	WRB
cord-007726-bqlf72fe	42	20	modeling	model	VBG
cord-007726-bqlf72fe	42	21	human	human	JJ
cord-007726-bqlf72fe	42	22	diseases	disease	NNS
cord-007726-bqlf72fe	42	23	involving	involve	VBG
cord-007726-bqlf72fe	42	24	the	the	DT
cord-007726-bqlf72fe	42	25	induction	induction	NN
cord-007726-bqlf72fe	42	26	of	of	IN
cord-007726-bqlf72fe	42	27	oxidative	oxidative	JJ
cord-007726-bqlf72fe	42	28	stress	stress	NN
cord-007726-bqlf72fe	42	29	(	(	-LRB-
cord-007726-bqlf72fe	42	30	i.e.	i.e.	FW
cord-007726-bqlf72fe	42	31	,	,	,
cord-007726-bqlf72fe	42	32	aging	aging	NN
cord-007726-bqlf72fe	42	33	,	,	,
cord-007726-bqlf72fe	42	34	inflammation	inflammation	NN
cord-007726-bqlf72fe	42	35	,	,	,
cord-007726-bqlf72fe	42	36	and	and	CC
cord-007726-bqlf72fe	42	37	neurodegeneration	neurodegeneration	NN
cord-007726-bqlf72fe	42	38	)	)	-RRB-
cord-007726-bqlf72fe	43	1	[	[	-LRB-
cord-007726-bqlf72fe	43	2	6	6	CD
cord-007726-bqlf72fe	43	3	]	]	-RRB-
cord-007726-bqlf72fe	43	4	.	.	.
cord-007726-bqlf72fe	44	1	The	the	DT
cord-007726-bqlf72fe	44	2	lung	lung	NN
cord-007726-bqlf72fe	44	3	provides	provide	VBZ
cord-007726-bqlf72fe	44	4	an	an	DT
cord-007726-bqlf72fe	44	5	excellent	excellent	JJ
cord-007726-bqlf72fe	44	6	example	example	NN
cord-007726-bqlf72fe	44	7	of	of	IN
cord-007726-bqlf72fe	44	8	the	the	DT
cord-007726-bqlf72fe	44	9	similarities	similarity	NNS
cord-007726-bqlf72fe	44	10	and	and	CC
cord-007726-bqlf72fe	44	11	differences	difference	NNS
cord-007726-bqlf72fe	44	12	between	between	IN
cord-007726-bqlf72fe	44	13	human	human	NN
cord-007726-bqlf72fe	44	14	and	and	CC
cord-007726-bqlf72fe	44	15	mouse	mouse	NN
cord-007726-bqlf72fe	44	16	anatomy	anatomy	NN
cord-007726-bqlf72fe	44	17	.	.	.
cord-007726-bqlf72fe	45	1	Similar	similar	JJ
cord-007726-bqlf72fe	45	2	to	to	IN
cord-007726-bqlf72fe	45	3	the	the	DT
cord-007726-bqlf72fe	45	4	human	human	JJ
cord-007726-bqlf72fe	45	5	organ	organ	NN
cord-007726-bqlf72fe	45	6	,	,	,
cord-007726-bqlf72fe	45	7	the	the	DT
cord-007726-bqlf72fe	45	8	mouse	mouse	NN
cord-007726-bqlf72fe	45	9	lung	lung	NN
cord-007726-bqlf72fe	45	10	is	be	VBZ
cord-007726-bqlf72fe	45	11	subdivided	subdivide	VBN
cord-007726-bqlf72fe	45	12	into	into	IN
cord-007726-bqlf72fe	45	13	lobes	lobe	NNS
cord-007726-bqlf72fe	45	14	of	of	IN
cord-007726-bqlf72fe	45	15	lung	lung	NN
cord-007726-bqlf72fe	45	16	parenchyma	parenchyma	NNS
cord-007726-bqlf72fe	45	17	containing	contain	VBG
cord-007726-bqlf72fe	45	18	a	a	DT
cord-007726-bqlf72fe	45	19	branching	branch	VBG
cord-007726-bqlf72fe	45	20	bronchial	bronchial	JJ
cord-007726-bqlf72fe	45	21	tree	tree	NN
cord-007726-bqlf72fe	45	22	and	and	CC
cord-007726-bqlf72fe	45	23	is	be	VBZ
cord-007726-bqlf72fe	45	24	vascularized	vascularize	VBN
cord-007726-bqlf72fe	45	25	by	by	IN
cord-007726-bqlf72fe	45	26	the	the	DT
cord-007726-bqlf72fe	45	27	pulmonary	pulmonary	JJ
cord-007726-bqlf72fe	45	28	circulation	circulation	NN
cord-007726-bqlf72fe	45	29	originating	originate	VBG
cord-007726-bqlf72fe	45	30	from	from	IN
cord-007726-bqlf72fe	45	31	the	the	DT
cord-007726-bqlf72fe	45	32	right	right	JJ
cord-007726-bqlf72fe	45	33	ventricle	ventricle	NN
cord-007726-bqlf72fe	45	34	.	.	.
cord-007726-bqlf72fe	46	1	There	there	EX
cord-007726-bqlf72fe	46	2	are	be	VBP
cord-007726-bqlf72fe	46	3	a	a	DT
cord-007726-bqlf72fe	46	4	number	number	NN
cord-007726-bqlf72fe	46	5	of	of	IN
cord-007726-bqlf72fe	46	6	subtle	subtle	JJ
cord-007726-bqlf72fe	46	7	variations	variation	NNS
cord-007726-bqlf72fe	46	8	in	in	IN
cord-007726-bqlf72fe	46	9	this	this	DT
cord-007726-bqlf72fe	46	10	general	general	JJ
cord-007726-bqlf72fe	46	11	structure	structure	NN
cord-007726-bqlf72fe	46	12	between	between	IN
cord-007726-bqlf72fe	46	13	species	specie	NNS
cord-007726-bqlf72fe	46	14	,	,	,
cord-007726-bqlf72fe	46	15	i.e.	i.e.	FW
cord-007726-bqlf72fe	46	16	,	,	,
cord-007726-bqlf72fe	46	17	the	the	DT
cord-007726-bqlf72fe	46	18	number	number	NN
cord-007726-bqlf72fe	46	19	of	of	IN
cord-007726-bqlf72fe	46	20	lobes	lobe	NNS
cord-007726-bqlf72fe	46	21	on	on	IN
cord-007726-bqlf72fe	46	22	the	the	DT
cord-007726-bqlf72fe	46	23	right	right	NN
cord-007726-bqlf72fe	46	24	and	and	CC
cord-007726-bqlf72fe	46	25	left	leave	VBD
cord-007726-bqlf72fe	46	26	,	,	,
cord-007726-bqlf72fe	46	27	the	the	DT
cord-007726-bqlf72fe	46	28	branching	branching	NN
cord-007726-bqlf72fe	46	29	pattern	pattern	NN
cord-007726-bqlf72fe	46	30	,	,	,
cord-007726-bqlf72fe	46	31	and	and	CC
cord-007726-bqlf72fe	46	32	the	the	DT
cord-007726-bqlf72fe	46	33	distribution	distribution	NN
cord-007726-bqlf72fe	46	34	of	of	IN
cord-007726-bqlf72fe	46	35	cartilage	cartilage	NN
cord-007726-bqlf72fe	46	36	rings	ring	NNS
cord-007726-bqlf72fe	46	37	around	around	IN
cord-007726-bqlf72fe	46	38	the	the	DT
cord-007726-bqlf72fe	46	39	large	large	JJ
cord-007726-bqlf72fe	46	40	airways	airway	NNS
cord-007726-bqlf72fe	46	41	,	,	,
cord-007726-bqlf72fe	46	42	but	but	CC
cord-007726-bqlf72fe	46	43	the	the	DT
cord-007726-bqlf72fe	46	44	most	most	RBS
cord-007726-bqlf72fe	46	45	important	important	JJ
cord-007726-bqlf72fe	46	46	differences	difference	NNS
cord-007726-bqlf72fe	46	47	between	between	IN
cord-007726-bqlf72fe	46	48	the	the	DT
cord-007726-bqlf72fe	46	49	mouse	mouse	NN
cord-007726-bqlf72fe	46	50	and	and	CC
cord-007726-bqlf72fe	46	51	human	human	JJ
cord-007726-bqlf72fe	46	52	lung	lung	NN
cord-007726-bqlf72fe	46	53	are	be	VBP
cord-007726-bqlf72fe	46	54	related	relate	VBN
cord-007726-bqlf72fe	46	55	to	to	IN
cord-007726-bqlf72fe	46	56	the	the	DT
cord-007726-bqlf72fe	46	57	organism	organism	NN
cord-007726-bqlf72fe	46	58	's	's	POS
cord-007726-bqlf72fe	46	59	size	size	NN
cord-007726-bqlf72fe	46	60	(	(	-LRB-
cord-007726-bqlf72fe	46	61	airway	airway	NN
cord-007726-bqlf72fe	46	62	diameter	diameter	NN
cord-007726-bqlf72fe	46	63	and	and	CC
cord-007726-bqlf72fe	46	64	alveolar	alveolar	JJ
cord-007726-bqlf72fe	46	65	size	size	NN
cord-007726-bqlf72fe	46	66	are	be	VBP
cord-007726-bqlf72fe	46	67	naturally	naturally	RB
cord-007726-bqlf72fe	46	68	much	much	RB
cord-007726-bqlf72fe	46	69	smaller	small	JJR
cord-007726-bqlf72fe	46	70	in	in	IN
cord-007726-bqlf72fe	46	71	the	the	DT
cord-007726-bqlf72fe	46	72	mouse	mouse	NN
cord-007726-bqlf72fe	46	73	)	)	-RRB-
cord-007726-bqlf72fe	46	74	and	and	CC
cord-007726-bqlf72fe	46	75	respiratory	respiratory	JJ
cord-007726-bqlf72fe	46	76	rate	rate	NN
cord-007726-bqlf72fe	46	77	.	.	.
cord-007726-bqlf72fe	47	1	Moreover	moreover	RB
cord-007726-bqlf72fe	47	2	,	,	,
cord-007726-bqlf72fe	47	3	there	there	EX
cord-007726-bqlf72fe	47	4	are	be	VBP
cord-007726-bqlf72fe	47	5	important	important	JJ
cord-007726-bqlf72fe	47	6	differences	difference	NNS
cord-007726-bqlf72fe	47	7	in	in	IN
cord-007726-bqlf72fe	47	8	the	the	DT
cord-007726-bqlf72fe	47	9	blood	blood	NN
cord-007726-bqlf72fe	47	10	supply	supply	NN
cord-007726-bqlf72fe	47	11	of	of	IN
cord-007726-bqlf72fe	47	12	the	the	DT
cord-007726-bqlf72fe	47	13	large	large	JJ
cord-007726-bqlf72fe	47	14	airways	airway	NNS
cord-007726-bqlf72fe	47	15	in	in	IN
cord-007726-bqlf72fe	47	16	humans	human	NNS
cord-007726-bqlf72fe	47	17	versus	versus	IN
cord-007726-bqlf72fe	47	18	mice	mouse	NNS
cord-007726-bqlf72fe	47	19	[	[	-LRB-
cord-007726-bqlf72fe	47	20	7	7	CD
cord-007726-bqlf72fe	47	21	]	]	-RRB-
cord-007726-bqlf72fe	47	22	.	.	.
cord-007726-bqlf72fe	48	1	Specifically	specifically	RB
cord-007726-bqlf72fe	48	2	,	,	,
cord-007726-bqlf72fe	48	3	the	the	DT
cord-007726-bqlf72fe	48	4	bronchial	bronchial	JJ
cord-007726-bqlf72fe	48	5	circulation	circulation	NN
cord-007726-bqlf72fe	48	6	(	(	-LRB-
cord-007726-bqlf72fe	48	7	a	a	DT
cord-007726-bqlf72fe	48	8	branch	branch	NN
cord-007726-bqlf72fe	48	9	of	of	IN
cord-007726-bqlf72fe	48	10	the	the	DT
cord-007726-bqlf72fe	48	11	high	high	JJ
cord-007726-bqlf72fe	48	12	-	-	HYPH
cord-007726-bqlf72fe	48	13	pressure	pressure	NN
cord-007726-bqlf72fe	48	14	systemic	systemic	JJ
cord-007726-bqlf72fe	48	15	circulation	circulation	NN
cord-007726-bqlf72fe	48	16	that	that	WDT
cord-007726-bqlf72fe	48	17	arises	arise	VBZ
cord-007726-bqlf72fe	48	18	from	from	IN
cord-007726-bqlf72fe	48	19	the	the	DT
cord-007726-bqlf72fe	48	20	aorta	aorta	JJ
cord-007726-bqlf72fe	48	21	and	and	CC
cord-007726-bqlf72fe	48	22	intercostal	intercostal	JJ
cord-007726-bqlf72fe	48	23	arteries	artery	NNS
cord-007726-bqlf72fe	48	24	)	)	-RRB-
cord-007726-bqlf72fe	48	25	supplies	supply	VBZ
cord-007726-bqlf72fe	48	26	a	a	DT
cord-007726-bqlf72fe	48	27	miniscule	miniscule	JJ
cord-007726-bqlf72fe	48	28	proportion	proportion	NN
cord-007726-bqlf72fe	48	29	of	of	IN
cord-007726-bqlf72fe	48	30	the	the	DT
cord-007726-bqlf72fe	48	31	pulmonary	pulmonary	JJ
cord-007726-bqlf72fe	48	32	tissue	tissue	NN
cord-007726-bqlf72fe	48	33	in	in	IN
cord-007726-bqlf72fe	48	34	mice	mouse	NNS
cord-007726-bqlf72fe	48	35	(	(	-LRB-
cord-007726-bqlf72fe	48	36	the	the	DT
cord-007726-bqlf72fe	48	37	trachea	trachea	NN
cord-007726-bqlf72fe	48	38	and	and	CC
cord-007726-bqlf72fe	48	39	bronchi	bronchi	NN
cord-007726-bqlf72fe	48	40	)	)	-RRB-
cord-007726-bqlf72fe	48	41	compared	compare	VBN
cord-007726-bqlf72fe	48	42	to	to	IN
cord-007726-bqlf72fe	48	43	humans	human	NNS
cord-007726-bqlf72fe	48	44	;	;	:
cord-007726-bqlf72fe	48	45	the	the	DT
cord-007726-bqlf72fe	48	46	majority	majority	NN
cord-007726-bqlf72fe	48	47	of	of	IN
cord-007726-bqlf72fe	48	48	the	the	DT
cord-007726-bqlf72fe	48	49	lung	lung	NN
cord-007726-bqlf72fe	48	50	parenchyma	parenchyma	NN
cord-007726-bqlf72fe	48	51	is	be	VBZ
cord-007726-bqlf72fe	48	52	supplied	supply	VBN
cord-007726-bqlf72fe	48	53	by	by	IN
cord-007726-bqlf72fe	48	54	the	the	DT
cord-007726-bqlf72fe	48	55	low	low	JJ
cord-007726-bqlf72fe	48	56	-	-	HYPH
cord-007726-bqlf72fe	48	57	pressure	pressure	NN
cord-007726-bqlf72fe	48	58	,	,	,
cord-007726-bqlf72fe	48	59	high	high	JJ
cord-007726-bqlf72fe	48	60	-	-	HYPH
cord-007726-bqlf72fe	48	61	flow	flow	NN
cord-007726-bqlf72fe	48	62	pulmonary	pulmonary	JJ
cord-007726-bqlf72fe	48	63	circulation	circulation	NN
cord-007726-bqlf72fe	48	64	.	.	.
cord-007726-bqlf72fe	49	1	In	in	IN
cord-007726-bqlf72fe	49	2	the	the	DT
cord-007726-bqlf72fe	49	3	mouse	mouse	NN
cord-007726-bqlf72fe	49	4	,	,	,
cord-007726-bqlf72fe	49	5	these	these	DT
cord-007726-bqlf72fe	49	6	systemic	systemic	JJ
cord-007726-bqlf72fe	49	7	blood	blood	NN
cord-007726-bqlf72fe	49	8	vessels	vessel	NNS
cord-007726-bqlf72fe	49	9	do	do	VBP
cord-007726-bqlf72fe	49	10	not	not	RB
cord-007726-bqlf72fe	49	11	penetrate	penetrate	VB
cord-007726-bqlf72fe	49	12	into	into	IN
cord-007726-bqlf72fe	49	13	the	the	DT
cord-007726-bqlf72fe	49	14	intraparenchymal	intraparenchymal	NNP
cord-007726-bqlf72fe	49	15	airways	airways	NNP
cord-007726-bqlf72fe	49	16	,	,	,
cord-007726-bqlf72fe	49	17	as	as	IN
cord-007726-bqlf72fe	49	18	they	-PRON-	PRP
cord-007726-bqlf72fe	49	19	do	do	VBP
cord-007726-bqlf72fe	49	20	in	in	IN
cord-007726-bqlf72fe	49	21	larger	large	JJR
cord-007726-bqlf72fe	49	22	species	specie	NNS
cord-007726-bqlf72fe	49	23	[	[	-LRB-
cord-007726-bqlf72fe	49	24	8	8	CD
cord-007726-bqlf72fe	49	25	]	]	-RRB-
cord-007726-bqlf72fe	49	26	.	.	.
cord-007726-bqlf72fe	50	1	This	this	DT
cord-007726-bqlf72fe	50	2	difference	difference	NN
cord-007726-bqlf72fe	50	3	,	,	,
cord-007726-bqlf72fe	50	4	although	although	IN
cord-007726-bqlf72fe	50	5	subtle	subtle	JJ
cord-007726-bqlf72fe	50	6	,	,	,
cord-007726-bqlf72fe	50	7	has	have	VBZ
cord-007726-bqlf72fe	50	8	important	important	JJ
cord-007726-bqlf72fe	50	9	ramifications	ramification	NNS
cord-007726-bqlf72fe	50	10	regarding	regard	VBG
cord-007726-bqlf72fe	50	11	the	the	DT
cord-007726-bqlf72fe	50	12	vascular	vascular	JJ
cord-007726-bqlf72fe	50	13	supply	supply	NN
cord-007726-bqlf72fe	50	14	of	of	IN
cord-007726-bqlf72fe	50	15	lung	lung	NN
cord-007726-bqlf72fe	50	16	tumors	tumor	NNS
cord-007726-bqlf72fe	50	17	which	which	WDT
cord-007726-bqlf72fe	50	18	,	,	,
cord-007726-bqlf72fe	50	19	in	in	IN
cord-007726-bqlf72fe	50	20	humans	human	NNS
cord-007726-bqlf72fe	50	21	,	,	,
cord-007726-bqlf72fe	50	22	is	be	VBZ
cord-007726-bqlf72fe	50	23	primarily	primarily	RB
cord-007726-bqlf72fe	50	24	derived	derive	VBN
cord-007726-bqlf72fe	50	25	from	from	IN
cord-007726-bqlf72fe	50	26	the	the	DT
cord-007726-bqlf72fe	50	27	systemic	systemic	JJ
cord-007726-bqlf72fe	50	28	circulation	circulation	NN
cord-007726-bqlf72fe	50	29	[	[	-LRB-
cord-007726-bqlf72fe	50	30	9	9	CD
cord-007726-bqlf72fe	50	31	]	]	-RRB-
cord-007726-bqlf72fe	50	32	.	.	.
cord-007726-bqlf72fe	51	1	These	these	DT
cord-007726-bqlf72fe	51	2	differences	difference	NNS
cord-007726-bqlf72fe	51	3	may	may	MD
cord-007726-bqlf72fe	51	4	also	also	RB
cord-007726-bqlf72fe	51	5	have	have	VB
cord-007726-bqlf72fe	51	6	profound	profound	JJ
cord-007726-bqlf72fe	51	7	consequences	consequence	NNS
cord-007726-bqlf72fe	51	8	when	when	WRB
cord-007726-bqlf72fe	51	9	modeling	model	VBG
cord-007726-bqlf72fe	51	10	human	human	JJ
cord-007726-bqlf72fe	51	11	diseases	disease	NNS
cord-007726-bqlf72fe	51	12	involving	involve	VBG
cord-007726-bqlf72fe	51	13	the	the	DT
cord-007726-bqlf72fe	51	14	lung	lung	NN
cord-007726-bqlf72fe	51	15	vasculature	vasculature	NN
cord-007726-bqlf72fe	51	16	.	.	.
cord-007726-bqlf72fe	52	1	The	the	DT
cord-007726-bqlf72fe	52	2	adaptive	adaptive	JJ
cord-007726-bqlf72fe	52	3	immune	immune	JJ
cord-007726-bqlf72fe	52	4	system	system	NN
cord-007726-bqlf72fe	52	5	evolved	evolve	VBD
cord-007726-bqlf72fe	52	6	in	in	IN
cord-007726-bqlf72fe	52	7	jawed	jawed	JJ
cord-007726-bqlf72fe	52	8	fish	fish	NN
cord-007726-bqlf72fe	52	9	about	about	IN
cord-007726-bqlf72fe	52	10	500	500	CD
cord-007726-bqlf72fe	52	11	million	million	CD
cord-007726-bqlf72fe	52	12	years	year	NNS
cord-007726-bqlf72fe	52	13	ago	ago	RB
cord-007726-bqlf72fe	52	14	,	,	,
cord-007726-bqlf72fe	52	15	well	well	RB
cord-007726-bqlf72fe	52	16	before	before	IN
cord-007726-bqlf72fe	52	17	the	the	DT
cord-007726-bqlf72fe	52	18	evolution	evolution	NN
cord-007726-bqlf72fe	52	19	of	of	IN
cord-007726-bqlf72fe	52	20	mammals	mammal	NNS
cord-007726-bqlf72fe	52	21	and	and	CC
cord-007726-bqlf72fe	52	22	the	the	DT
cord-007726-bqlf72fe	52	23	divergence	divergence	NN
cord-007726-bqlf72fe	52	24	of	of	IN
cord-007726-bqlf72fe	52	25	mouse	mouse	NN
cord-007726-bqlf72fe	52	26	and	and	CC
cord-007726-bqlf72fe	52	27	human	human	JJ
cord-007726-bqlf72fe	52	28	ancestral	ancestral	JJ
cord-007726-bqlf72fe	52	29	species	specie	NNS
cord-007726-bqlf72fe	52	30	[	[	-LRB-
cord-007726-bqlf72fe	52	31	10	10	CD
cord-007726-bqlf72fe	52	32	]	]	-RRB-
cord-007726-bqlf72fe	52	33	.	.	.
cord-007726-bqlf72fe	53	1	Many	many	JJ
cord-007726-bqlf72fe	53	2	features	feature	NNS
cord-007726-bqlf72fe	53	3	of	of	IN
cord-007726-bqlf72fe	53	4	the	the	DT
cord-007726-bqlf72fe	53	5	adaptive	adaptive	JJ
cord-007726-bqlf72fe	53	6	immune	immune	JJ
cord-007726-bqlf72fe	53	7	system	system	NN
cord-007726-bqlf72fe	53	8	,	,	,
cord-007726-bqlf72fe	53	9	including	include	VBG
cord-007726-bqlf72fe	53	10	antigen	antigen	NN
cord-007726-bqlf72fe	53	11	recognition	recognition	NN
cord-007726-bqlf72fe	53	12	,	,	,
cord-007726-bqlf72fe	53	13	clonal	clonal	JJ
cord-007726-bqlf72fe	53	14	selection	selection	NN
cord-007726-bqlf72fe	53	15	,	,	,
cord-007726-bqlf72fe	53	16	antibody	antibody	NN
cord-007726-bqlf72fe	53	17	production	production	NN
cord-007726-bqlf72fe	53	18	,	,	,
cord-007726-bqlf72fe	53	19	and	and	CC
cord-007726-bqlf72fe	53	20	immunological	immunological	JJ
cord-007726-bqlf72fe	53	21	tolerance	tolerance	NN
cord-007726-bqlf72fe	53	22	,	,	,
cord-007726-bqlf72fe	53	23	have	have	VBP
cord-007726-bqlf72fe	53	24	been	be	VBN
cord-007726-bqlf72fe	53	25	maintained	maintain	VBN
cord-007726-bqlf72fe	53	26	since	since	IN
cord-007726-bqlf72fe	53	27	they	-PRON-	PRP
cord-007726-bqlf72fe	53	28	first	first	RB
cord-007726-bqlf72fe	53	29	arose	arise	VBD
cord-007726-bqlf72fe	53	30	in	in	IN
cord-007726-bqlf72fe	53	31	early	early	JJ
cord-007726-bqlf72fe	53	32	vertebrates	vertebrate	NNS
cord-007726-bqlf72fe	53	33	.	.	.
cord-007726-bqlf72fe	54	1	However	however	RB
cord-007726-bqlf72fe	54	2	,	,	,
cord-007726-bqlf72fe	54	3	the	the	DT
cord-007726-bqlf72fe	54	4	finer	fine	JJR
cord-007726-bqlf72fe	54	5	details	detail	NNS
cord-007726-bqlf72fe	54	6	of	of	IN
cord-007726-bqlf72fe	54	7	the	the	DT
cord-007726-bqlf72fe	54	8	mouse	mouse	NN
cord-007726-bqlf72fe	54	9	and	and	CC
cord-007726-bqlf72fe	54	10	human	human	JJ
cord-007726-bqlf72fe	54	11	immune	immune	JJ
cord-007726-bqlf72fe	54	12	systems	system	NNS
cord-007726-bqlf72fe	54	13	differ	differ	VBP
cord-007726-bqlf72fe	54	14	considerably	considerably	RB
cord-007726-bqlf72fe	54	15	,	,	,
cord-007726-bqlf72fe	54	16	which	which	WDT
cord-007726-bqlf72fe	54	17	is	be	VBZ
cord-007726-bqlf72fe	54	18	not	not	RB
cord-007726-bqlf72fe	54	19	surprising	surprising	JJ
cord-007726-bqlf72fe	54	20	since	since	IN
cord-007726-bqlf72fe	54	21	these	these	DT
cord-007726-bqlf72fe	54	22	species	specie	NNS
cord-007726-bqlf72fe	54	23	diverged	diverge	VBD
cord-007726-bqlf72fe	54	24	75	75	CD
cord-007726-bqlf72fe	54	25	million	million	CD
cord-007726-bqlf72fe	54	26	years	year	NNS
cord-007726-bqlf72fe	54	27	ago	ago	RB
cord-007726-bqlf72fe	54	28	[	[	-LRB-
cord-007726-bqlf72fe	54	29	6	6	CD
cord-007726-bqlf72fe	54	30	]	]	-RRB-
cord-007726-bqlf72fe	54	31	.	.	.
cord-007726-bqlf72fe	55	1	While	while	IN
cord-007726-bqlf72fe	55	2	some	some	DT
cord-007726-bqlf72fe	55	3	have	have	VBP
cord-007726-bqlf72fe	55	4	claimed	claim	VBN
cord-007726-bqlf72fe	55	5	that	that	IN
cord-007726-bqlf72fe	55	6	these	these	DT
cord-007726-bqlf72fe	55	7	differences	difference	NNS
cord-007726-bqlf72fe	55	8	mean	mean	VBP
cord-007726-bqlf72fe	55	9	that	that	DT
cord-007726-bqlf72fe	55	10	research	research	NN
cord-007726-bqlf72fe	55	11	into	into	IN
cord-007726-bqlf72fe	55	12	immunological	immunological	JJ
cord-007726-bqlf72fe	55	13	phenomena	phenomenon	NNS
cord-007726-bqlf72fe	55	14	in	in	IN
cord-007726-bqlf72fe	55	15	mice	mice	NN
cord-007726-bqlf72fe	55	16	is	be	VBZ
cord-007726-bqlf72fe	55	17	not	not	RB
cord-007726-bqlf72fe	55	18	transferable	transferable	JJ
cord-007726-bqlf72fe	55	19	to	to	IN
cord-007726-bqlf72fe	55	20	humans	human	NNS
cord-007726-bqlf72fe	55	21	,	,	,
cord-007726-bqlf72fe	55	22	as	as	RB
cord-007726-bqlf72fe	55	23	long	long	RB
cord-007726-bqlf72fe	55	24	as	as	IN
cord-007726-bqlf72fe	55	25	these	these	DT
cord-007726-bqlf72fe	55	26	differences	difference	NNS
cord-007726-bqlf72fe	55	27	are	be	VBP
cord-007726-bqlf72fe	55	28	understood	understand	VBN
cord-007726-bqlf72fe	55	29	and	and	CC
cord-007726-bqlf72fe	55	30	acknowledged	acknowledge	VBN
cord-007726-bqlf72fe	55	31	,	,	,
cord-007726-bqlf72fe	55	32	the	the	DT
cord-007726-bqlf72fe	55	33	study	study	NN
cord-007726-bqlf72fe	55	34	of	of	IN
cord-007726-bqlf72fe	55	35	mouse	mouse	NN
cord-007726-bqlf72fe	55	36	immune	immune	JJ
cord-007726-bqlf72fe	55	37	responses	response	NNS
cord-007726-bqlf72fe	55	38	can	can	MD
cord-007726-bqlf72fe	55	39	continue	continue	VB
cord-007726-bqlf72fe	55	40	to	to	TO
cord-007726-bqlf72fe	55	41	be	be	VB
cord-007726-bqlf72fe	55	42	relevant	relevant	JJ
cord-007726-bqlf72fe	55	43	.	.	.
cord-007726-bqlf72fe	56	1	Research	research	NN
cord-007726-bqlf72fe	56	2	on	on	IN
cord-007726-bqlf72fe	56	3	mice	mouse	NNS
cord-007726-bqlf72fe	56	4	has	have	VBZ
cord-007726-bqlf72fe	56	5	been	be	VBN
cord-007726-bqlf72fe	56	6	vital	vital	JJ
cord-007726-bqlf72fe	56	7	to	to	IN
cord-007726-bqlf72fe	56	8	the	the	DT
cord-007726-bqlf72fe	56	9	discovery	discovery	NN
cord-007726-bqlf72fe	56	10	of	of	IN
cord-007726-bqlf72fe	56	11	key	key	JJ
cord-007726-bqlf72fe	56	12	features	feature	NNS
cord-007726-bqlf72fe	56	13	of	of	IN
cord-007726-bqlf72fe	56	14	both	both	DT
cord-007726-bqlf72fe	56	15	innate	innate	JJ
cord-007726-bqlf72fe	56	16	and	and	CC
cord-007726-bqlf72fe	56	17	adaptive	adaptive	JJ
cord-007726-bqlf72fe	56	18	immune	immune	JJ
cord-007726-bqlf72fe	56	19	responses	response	NNS
cord-007726-bqlf72fe	56	20	;	;	:
cord-007726-bqlf72fe	56	21	for	for	IN
cord-007726-bqlf72fe	56	22	example	example	NN
cord-007726-bqlf72fe	56	23	,	,	,
cord-007726-bqlf72fe	56	24	the	the	DT
cord-007726-bqlf72fe	56	25	first	first	JJ
cord-007726-bqlf72fe	56	26	descriptions	description	NNS
cord-007726-bqlf72fe	56	27	of	of	IN
cord-007726-bqlf72fe	56	28	the	the	DT
cord-007726-bqlf72fe	56	29	major	major	JJ
cord-007726-bqlf72fe	56	30	histocompatibility	histocompatibility	NN
cord-007726-bqlf72fe	56	31	complex	complex	NN
cord-007726-bqlf72fe	56	32	,	,	,
cord-007726-bqlf72fe	56	33	the	the	DT
cord-007726-bqlf72fe	56	34	T	T	NNP
cord-007726-bqlf72fe	56	35	cell	cell	NN
cord-007726-bqlf72fe	56	36	receptor	receptor	NN
cord-007726-bqlf72fe	56	37	,	,	,
cord-007726-bqlf72fe	56	38	and	and	CC
cord-007726-bqlf72fe	56	39	antibody	antibody	NN
cord-007726-bqlf72fe	56	40	synthesis	synthesis	NN
cord-007726-bqlf72fe	56	41	were	be	VBD
cord-007726-bqlf72fe	56	42	derived	derive	VBN
cord-007726-bqlf72fe	56	43	from	from	IN
cord-007726-bqlf72fe	56	44	experiments	experiment	NNS
cord-007726-bqlf72fe	56	45	performed	perform	VBN
cord-007726-bqlf72fe	56	46	on	on	IN
cord-007726-bqlf72fe	56	47	mice	mouse	NNS
cord-007726-bqlf72fe	56	48	[	[	-LRB-
cord-007726-bqlf72fe	56	49	6	6	CD
cord-007726-bqlf72fe	56	50	]	]	-RRB-
cord-007726-bqlf72fe	56	51	.	.	.
cord-007726-bqlf72fe	57	1	The	the	DT
cord-007726-bqlf72fe	57	2	general	general	JJ
cord-007726-bqlf72fe	57	3	structure	structure	NN
cord-007726-bqlf72fe	57	4	of	of	IN
cord-007726-bqlf72fe	57	5	the	the	DT
cord-007726-bqlf72fe	57	6	immune	immune	JJ
cord-007726-bqlf72fe	57	7	system	system	NN
cord-007726-bqlf72fe	57	8	is	be	VBZ
cord-007726-bqlf72fe	57	9	similar	similar	JJ
cord-007726-bqlf72fe	57	10	in	in	IN
cord-007726-bqlf72fe	57	11	mice	mouse	NNS
cord-007726-bqlf72fe	57	12	and	and	CC
cord-007726-bqlf72fe	57	13	humans	human	NNS
cord-007726-bqlf72fe	57	14	,	,	,
cord-007726-bqlf72fe	57	15	with	with	IN
cord-007726-bqlf72fe	57	16	similar	similar	JJ
cord-007726-bqlf72fe	57	17	mediators	mediator	NNS
cord-007726-bqlf72fe	57	18	and	and	CC
cord-007726-bqlf72fe	57	19	cell	cell	NN
cord-007726-bqlf72fe	57	20	types	type	NNS
cord-007726-bqlf72fe	57	21	involved	involve	VBN
cord-007726-bqlf72fe	57	22	in	in	IN
cord-007726-bqlf72fe	57	23	rapid	rapid	JJ
cord-007726-bqlf72fe	57	24	,	,	,
cord-007726-bqlf72fe	57	25	innate	innate	JJ
cord-007726-bqlf72fe	57	26	immune	immune	JJ
cord-007726-bqlf72fe	57	27	responses	response	NNS
cord-007726-bqlf72fe	57	28	(	(	-LRB-
cord-007726-bqlf72fe	57	29	complement	complement	NN
cord-007726-bqlf72fe	57	30	,	,	,
cord-007726-bqlf72fe	57	31	macrophages	macrophage	NNS
cord-007726-bqlf72fe	57	32	,	,	,
cord-007726-bqlf72fe	57	33	neutrophils	neutrophil	NNS
cord-007726-bqlf72fe	57	34	,	,	,
cord-007726-bqlf72fe	57	35	and	and	CC
cord-007726-bqlf72fe	57	36	natural	natural	JJ
cord-007726-bqlf72fe	57	37	killer	killer	NN
cord-007726-bqlf72fe	57	38	cells	cell	NNS
cord-007726-bqlf72fe	57	39	)	)	-RRB-
cord-007726-bqlf72fe	57	40	as	as	RB
cord-007726-bqlf72fe	57	41	well	well	RB
cord-007726-bqlf72fe	57	42	as	as	IN
cord-007726-bqlf72fe	57	43	adaptive	adaptive	JJ
cord-007726-bqlf72fe	57	44	immune	immune	JJ
cord-007726-bqlf72fe	57	45	responses	response	NNS
cord-007726-bqlf72fe	57	46	informed	inform	VBN
cord-007726-bqlf72fe	57	47	by	by	IN
cord-007726-bqlf72fe	57	48	antigen	antigen	NN
cord-007726-bqlf72fe	57	49	-	-	HYPH
cord-007726-bqlf72fe	57	50	presenting	present	VBG
cord-007726-bqlf72fe	57	51	dendritic	dendritic	JJ
cord-007726-bqlf72fe	57	52	cells	cell	NNS
cord-007726-bqlf72fe	57	53	and	and	CC
cord-007726-bqlf72fe	57	54	executed	execute	VBN
cord-007726-bqlf72fe	57	55	by	by	IN
cord-007726-bqlf72fe	57	56	B	B	NNP
cord-007726-bqlf72fe	57	57	and	and	CC
cord-007726-bqlf72fe	57	58	T	t	NN
cord-007726-bqlf72fe	57	59	cells	cell	NNS
cord-007726-bqlf72fe	57	60	.	.	.
cord-007726-bqlf72fe	58	1	However	however	RB
cord-007726-bqlf72fe	58	2	,	,	,
cord-007726-bqlf72fe	58	3	due	due	IN
cord-007726-bqlf72fe	58	4	to	to	IN
cord-007726-bqlf72fe	58	5	the	the	DT
cord-007726-bqlf72fe	58	6	anatomical	anatomical	JJ
cord-007726-bqlf72fe	58	7	and	and	CC
cord-007726-bqlf72fe	58	8	physiological	physiological	JJ
cord-007726-bqlf72fe	58	9	differences	difference	NNS
cord-007726-bqlf72fe	58	10	between	between	IN
cord-007726-bqlf72fe	58	11	these	these	DT
cord-007726-bqlf72fe	58	12	species	specie	NNS
cord-007726-bqlf72fe	58	13	as	as	IN
cord-007726-bqlf72fe	58	14	described	describe	VBN
cord-007726-bqlf72fe	58	15	above	above	RB
cord-007726-bqlf72fe	58	16	,	,	,
cord-007726-bqlf72fe	58	17	divergence	divergence	NN
cord-007726-bqlf72fe	58	18	in	in	IN
cord-007726-bqlf72fe	58	19	key	key	JJ
cord-007726-bqlf72fe	58	20	features	feature	NNS
cord-007726-bqlf72fe	58	21	of	of	IN
cord-007726-bqlf72fe	58	22	the	the	DT
cord-007726-bqlf72fe	58	23	immune	immune	JJ
cord-007726-bqlf72fe	58	24	system	system	NN
cord-007726-bqlf72fe	58	25	,	,	,
cord-007726-bqlf72fe	58	26	such	such	JJ
cord-007726-bqlf72fe	58	27	as	as	IN
cord-007726-bqlf72fe	58	28	the	the	DT
cord-007726-bqlf72fe	58	29	maintenance	maintenance	NN
cord-007726-bqlf72fe	58	30	of	of	IN
cord-007726-bqlf72fe	58	31	memory	memory	NN
cord-007726-bqlf72fe	58	32	T	T	NNP
cord-007726-bqlf72fe	58	33	cells	cell	NNS
cord-007726-bqlf72fe	58	34	(	(	-LRB-
cord-007726-bqlf72fe	58	35	related	relate	VBN
cord-007726-bqlf72fe	58	36	to	to	IN
cord-007726-bqlf72fe	58	37	the	the	DT
cord-007726-bqlf72fe	58	38	life	life	NN
cord-007726-bqlf72fe	58	39	span	span	NN
cord-007726-bqlf72fe	58	40	of	of	IN
cord-007726-bqlf72fe	58	41	the	the	DT
cord-007726-bqlf72fe	58	42	organism	organism	NN
cord-007726-bqlf72fe	58	43	)	)	-RRB-
cord-007726-bqlf72fe	58	44	and	and	CC
cord-007726-bqlf72fe	58	45	the	the	DT
cord-007726-bqlf72fe	58	46	commensal	commensal	JJ
cord-007726-bqlf72fe	58	47	microbiota	microbiota	NN
cord-007726-bqlf72fe	58	48	(	(	-LRB-
cord-007726-bqlf72fe	58	49	related	relate	VBN
cord-007726-bqlf72fe	58	50	to	to	IN
cord-007726-bqlf72fe	58	51	the	the	DT
cord-007726-bqlf72fe	58	52	lifestyle	lifestyle	NN
cord-007726-bqlf72fe	58	53	of	of	IN
cord-007726-bqlf72fe	58	54	the	the	DT
cord-007726-bqlf72fe	58	55	organism	organism	NN
cord-007726-bqlf72fe	58	56	)	)	-RRB-
cord-007726-bqlf72fe	58	57	,	,	,
cord-007726-bqlf72fe	58	58	has	have	VBZ
cord-007726-bqlf72fe	58	59	arisen	arise	VBN
cord-007726-bqlf72fe	58	60	[	[	-LRB-
cord-007726-bqlf72fe	58	61	11	11	CD
cord-007726-bqlf72fe	58	62	]	]	-RRB-
cord-007726-bqlf72fe	58	63	.	.	.
cord-007726-bqlf72fe	59	1	Similar	similar	JJ
cord-007726-bqlf72fe	59	2	to	to	IN
cord-007726-bqlf72fe	59	3	what	what	WP
cord-007726-bqlf72fe	59	4	has	have	VBZ
cord-007726-bqlf72fe	59	5	been	be	VBN
cord-007726-bqlf72fe	59	6	discovered	discover	VBN
cord-007726-bqlf72fe	59	7	regarding	regard	VBG
cord-007726-bqlf72fe	59	8	the	the	DT
cord-007726-bqlf72fe	59	9	genetics	genetic	NNS
cord-007726-bqlf72fe	59	10	of	of	IN
cord-007726-bqlf72fe	59	11	mice	mouse	NNS
cord-007726-bqlf72fe	59	12	and	and	CC
cord-007726-bqlf72fe	59	13	humans	human	NNS
cord-007726-bqlf72fe	59	14	,	,	,
cord-007726-bqlf72fe	59	15	i.e.	i.e.	FW
cord-007726-bqlf72fe	59	16	,	,	,
cord-007726-bqlf72fe	59	17	broad	broad	JJ
cord-007726-bqlf72fe	59	18	similarities	similarity	NNS
cord-007726-bqlf72fe	59	19	in	in	IN
cord-007726-bqlf72fe	59	20	structure	structure	NN
cord-007726-bqlf72fe	59	21	but	but	CC
cord-007726-bqlf72fe	59	22	considerable	considerable	JJ
cord-007726-bqlf72fe	59	23	differences	difference	NNS
cord-007726-bqlf72fe	59	24	in	in	IN
cord-007726-bqlf72fe	59	25	regulation	regulation	NN
cord-007726-bqlf72fe	60	1	,	,	,
cord-007726-bqlf72fe	60	2	there	there	EX
cord-007726-bqlf72fe	60	3	are	be	VBP
cord-007726-bqlf72fe	60	4	a	a	DT
cord-007726-bqlf72fe	60	5	number	number	NN
cord-007726-bqlf72fe	60	6	of	of	IN
cord-007726-bqlf72fe	60	7	known	know	VBN
cord-007726-bqlf72fe	60	8	discrepancies	discrepancy	NNS
cord-007726-bqlf72fe	60	9	in	in	IN
cord-007726-bqlf72fe	60	10	the	the	DT
cord-007726-bqlf72fe	60	11	regulation	regulation	NN
cord-007726-bqlf72fe	60	12	of	of	IN
cord-007726-bqlf72fe	60	13	innate	innate	JJ
cord-007726-bqlf72fe	60	14	and	and	CC
cord-007726-bqlf72fe	60	15	adaptive	adaptive	JJ
cord-007726-bqlf72fe	60	16	immunity	immunity	NN
cord-007726-bqlf72fe	60	17	in	in	IN
cord-007726-bqlf72fe	60	18	Mouse	Mouse	NNP
cord-007726-bqlf72fe	60	19	Models	Models	NNPS
cord-007726-bqlf72fe	60	20	of	of	IN
cord-007726-bqlf72fe	60	21	Human	Human	NNP
cord-007726-bqlf72fe	60	22	Disease	Disease	NNP
cord-007726-bqlf72fe	60	23	mice	mouse	NNS
cord-007726-bqlf72fe	60	24	versus	versus	IN
cord-007726-bqlf72fe	60	25	humans	human	NNS
cord-007726-bqlf72fe	60	26	,	,	,
cord-007726-bqlf72fe	60	27	including	include	VBG
cord-007726-bqlf72fe	60	28	the	the	DT
cord-007726-bqlf72fe	60	29	balance	balance	NN
cord-007726-bqlf72fe	60	30	of	of	IN
cord-007726-bqlf72fe	60	31	leukocyte	leukocyte	NN
cord-007726-bqlf72fe	60	32	subsets	subset	NNS
cord-007726-bqlf72fe	60	33	,	,	,
cord-007726-bqlf72fe	60	34	T	T	NNP
cord-007726-bqlf72fe	60	35	cell	cell	NN
cord-007726-bqlf72fe	60	36	activation	activation	NN
cord-007726-bqlf72fe	60	37	and	and	CC
cord-007726-bqlf72fe	60	38	costimulation	costimulation	NN
cord-007726-bqlf72fe	60	39	,	,	,
cord-007726-bqlf72fe	60	40	antibody	antibody	NN
cord-007726-bqlf72fe	60	41	subtypes	subtype	NNS
cord-007726-bqlf72fe	60	42	and	and	CC
cord-007726-bqlf72fe	60	43	cellular	cellular	JJ
cord-007726-bqlf72fe	60	44	responses	response	NNS
cord-007726-bqlf72fe	60	45	to	to	IN
cord-007726-bqlf72fe	60	46	antibody	antibody	NN
cord-007726-bqlf72fe	60	47	,	,	,
cord-007726-bqlf72fe	60	48	Th1	Th1	NNP
cord-007726-bqlf72fe	60	49	/	/	SYM
cord-007726-bqlf72fe	60	50	Th2	th2	CD
cord-007726-bqlf72fe	60	51	differentiation	differentiation	NN
cord-007726-bqlf72fe	60	52	,	,	,
cord-007726-bqlf72fe	60	53	and	and	CC
cord-007726-bqlf72fe	60	54	responses	response	NNS
cord-007726-bqlf72fe	60	55	to	to	IN
cord-007726-bqlf72fe	60	56	pathogens	pathogen	NNS
cord-007726-bqlf72fe	60	57	(	(	-LRB-
cord-007726-bqlf72fe	60	58	described	describe	VBN
cord-007726-bqlf72fe	60	59	in	in	IN
cord-007726-bqlf72fe	60	60	detail	detail	NN
cord-007726-bqlf72fe	60	61	in	in	IN
cord-007726-bqlf72fe	60	62	Table	Table	NNP
cord-007726-bqlf72fe	60	63	1	1	CD
cord-007726-bqlf72fe	60	64	)	)	-RRB-
cord-007726-bqlf72fe	60	65	.	.	.
cord-007726-bqlf72fe	61	1	In	in	IN
cord-007726-bqlf72fe	61	2	addition	addition	NN
cord-007726-bqlf72fe	61	3	to	to	IN
cord-007726-bqlf72fe	61	4	these	these	DT
cord-007726-bqlf72fe	61	5	differences	difference	NNS
cord-007726-bqlf72fe	61	6	in	in	IN
cord-007726-bqlf72fe	61	7	immune	immune	JJ
cord-007726-bqlf72fe	61	8	cell	cell	NN
cord-007726-bqlf72fe	61	9	functions	function	NNS
cord-007726-bqlf72fe	61	10	,	,	,
cord-007726-bqlf72fe	61	11	the	the	DT
cord-007726-bqlf72fe	61	12	expression	expression	NN
cord-007726-bqlf72fe	61	13	of	of	IN
cord-007726-bqlf72fe	61	14	specific	specific	JJ
cord-007726-bqlf72fe	61	15	genes	gene	NNS
cord-007726-bqlf72fe	61	16	involved	involve	VBN
cord-007726-bqlf72fe	61	17	in	in	IN
cord-007726-bqlf72fe	61	18	immune	immune	JJ
cord-007726-bqlf72fe	61	19	responses	response	NNS
cord-007726-bqlf72fe	61	20	also	also	RB
cord-007726-bqlf72fe	61	21	differs	differ	VBZ
cord-007726-bqlf72fe	61	22	,	,	,
cord-007726-bqlf72fe	61	23	particularly	particularly	RB
cord-007726-bqlf72fe	61	24	those	those	DT
cord-007726-bqlf72fe	61	25	for	for	IN
cord-007726-bqlf72fe	61	26	Toll	toll	NN
cord-007726-bqlf72fe	61	27	-	-	HYPH
cord-007726-bqlf72fe	61	28	like	like	JJ
cord-007726-bqlf72fe	61	29	receptors	receptor	NNS
cord-007726-bqlf72fe	61	30	,	,	,
cord-007726-bqlf72fe	61	31	defensins	defensin	NNS
cord-007726-bqlf72fe	61	32	,	,	,
cord-007726-bqlf72fe	61	33	NK	NK	NNP
cord-007726-bqlf72fe	61	34	inhibitory	inhibitory	JJ
cord-007726-bqlf72fe	61	35	receptors	receptor	NNS
cord-007726-bqlf72fe	61	36	,	,	,
cord-007726-bqlf72fe	61	37	Thy-1	Thy-1	NNP
cord-007726-bqlf72fe	61	38	,	,	,
cord-007726-bqlf72fe	61	39	and	and	CC
cord-007726-bqlf72fe	61	40	many	many	JJ
cord-007726-bqlf72fe	61	41	components	component	NNS
cord-007726-bqlf72fe	61	42	of	of	IN
cord-007726-bqlf72fe	61	43	chemokine	chemokine	NN
cord-007726-bqlf72fe	61	44	and	and	CC
cord-007726-bqlf72fe	61	45	cytokine	cytokine	NN
cord-007726-bqlf72fe	61	46	signaling	signaling	NN
cord-007726-bqlf72fe	61	47	;	;	:
cord-007726-bqlf72fe	61	48	additionally	additionally	RB
cord-007726-bqlf72fe	61	49	,	,	,
cord-007726-bqlf72fe	61	50	differences	difference	NNS
cord-007726-bqlf72fe	61	51	between	between	IN
cord-007726-bqlf72fe	61	52	mouse	mouse	NN
cord-007726-bqlf72fe	61	53	strains	strain	NNS
cord-007726-bqlf72fe	61	54	are	be	VBP
cord-007726-bqlf72fe	61	55	known	know	VBN
cord-007726-bqlf72fe	61	56	to	to	TO
cord-007726-bqlf72fe	61	57	exist	exist	VB
cord-007726-bqlf72fe	61	58	for	for	IN
cord-007726-bqlf72fe	61	59	many	many	JJ
cord-007726-bqlf72fe	61	60	of	of	IN
cord-007726-bqlf72fe	61	61	these	these	DT
cord-007726-bqlf72fe	61	62	mediators	mediator	NNS
cord-007726-bqlf72fe	61	63	[	[	-LRB-
cord-007726-bqlf72fe	61	64	12	12	CD
cord-007726-bqlf72fe	61	65	]	]	-RRB-
cord-007726-bqlf72fe	61	66	.	.	.
cord-007726-bqlf72fe	62	1	Another	another	DT
cord-007726-bqlf72fe	62	2	important	important	JJ
cord-007726-bqlf72fe	62	3	consideration	consideration	NN
cord-007726-bqlf72fe	62	4	when	when	WRB
cord-007726-bqlf72fe	62	5	using	use	VBG
cord-007726-bqlf72fe	62	6	mice	mouse	NNS
cord-007726-bqlf72fe	62	7	to	to	TO
cord-007726-bqlf72fe	62	8	perform	perform	VB
cord-007726-bqlf72fe	62	9	immunological	immunological	JJ
cord-007726-bqlf72fe	62	10	research	research	NN
cord-007726-bqlf72fe	62	11	(	(	-LRB-
cord-007726-bqlf72fe	62	12	with	with	IN
cord-007726-bqlf72fe	62	13	a	a	DT
cord-007726-bqlf72fe	62	14	view	view	NN
cord-007726-bqlf72fe	62	15	to	to	IN
cord-007726-bqlf72fe	62	16	translating	translate	VBG
cord-007726-bqlf72fe	62	17	these	these	DT
cord-007726-bqlf72fe	62	18	findings	finding	NNS
cord-007726-bqlf72fe	62	19	to	to	IN
cord-007726-bqlf72fe	62	20	human	human	JJ
cord-007726-bqlf72fe	62	21	medicine	medicine	NN
cord-007726-bqlf72fe	62	22	)	)	-RRB-
cord-007726-bqlf72fe	62	23	is	be	VBZ
cord-007726-bqlf72fe	62	24	the	the	DT
cord-007726-bqlf72fe	62	25	availability	availability	NN
cord-007726-bqlf72fe	62	26	of	of	IN
cord-007726-bqlf72fe	62	27	hundreds	hundred	NNS
cord-007726-bqlf72fe	62	28	of	of	IN
cord-007726-bqlf72fe	62	29	strains	strain	NNS
cord-007726-bqlf72fe	62	30	of	of	IN
cord-007726-bqlf72fe	62	31	genetically	genetically	RB
cord-007726-bqlf72fe	62	32	modified	modify	VBN
cord-007726-bqlf72fe	62	33	mice	mouse	NNS
cord-007726-bqlf72fe	62	34	that	that	WDT
cord-007726-bqlf72fe	62	35	have	have	VBP
cord-007726-bqlf72fe	62	36	enabled	enable	VBN
cord-007726-bqlf72fe	62	37	exquisitely	exquisitely	RB
cord-007726-bqlf72fe	62	38	detailed	detail	VBN
cord-007726-bqlf72fe	62	39	studies	study	NNS
cord-007726-bqlf72fe	62	40	on	on	IN
cord-007726-bqlf72fe	62	41	immune	immune	JJ
cord-007726-bqlf72fe	62	42	cell	cell	NN
cord-007726-bqlf72fe	62	43	function	function	NN
cord-007726-bqlf72fe	62	44	,	,	,
cord-007726-bqlf72fe	62	45	regulation	regulation	NN
cord-007726-bqlf72fe	62	46	,	,	,
cord-007726-bqlf72fe	62	47	and	and	CC
cord-007726-bqlf72fe	62	48	trafficking	trafficking	NN
cord-007726-bqlf72fe	62	49	.	.	.
cord-007726-bqlf72fe	63	1	Many	many	JJ
cord-007726-bqlf72fe	63	2	of	of	IN
cord-007726-bqlf72fe	63	3	these	these	DT
cord-007726-bqlf72fe	63	4	strains	strain	NNS
cord-007726-bqlf72fe	63	5	involve	involve	VBP
cord-007726-bqlf72fe	63	6	the	the	DT
cord-007726-bqlf72fe	63	7	expression	expression	NN
cord-007726-bqlf72fe	63	8	of	of	IN
cord-007726-bqlf72fe	63	9	inducible	inducible	JJ
cord-007726-bqlf72fe	63	10	Cre	Cre	NNP
cord-007726-bqlf72fe	63	11	or	or	CC
cord-007726-bqlf72fe	63	12	Cas9	Cas9	NNP
cord-007726-bqlf72fe	63	13	that	that	WDT
cord-007726-bqlf72fe	63	14	allow	allow	VBP
cord-007726-bqlf72fe	63	15	for	for	IN
cord-007726-bqlf72fe	63	16	targeted	target	VBN
cord-007726-bqlf72fe	63	17	knockdown	knockdown	NN
cord-007726-bqlf72fe	63	18	or	or	CC
cord-007726-bqlf72fe	63	19	overexpression	overexpression	NN
cord-007726-bqlf72fe	63	20	of	of	IN
cord-007726-bqlf72fe	63	21	key	key	JJ
cord-007726-bqlf72fe	63	22	immune	immune	JJ
cord-007726-bqlf72fe	63	23	function	function	NN
cord-007726-bqlf72fe	63	24	-	-	HYPH
cord-007726-bqlf72fe	63	25	related	relate	VBN
cord-007726-bqlf72fe	63	26	genes	gene	NNS
cord-007726-bqlf72fe	63	27	in	in	IN
cord-007726-bqlf72fe	63	28	specific	specific	JJ
cord-007726-bqlf72fe	63	29	cell	cell	NN
cord-007726-bqlf72fe	63	30	types	type	NNS
cord-007726-bqlf72fe	63	31	at	at	IN
cord-007726-bqlf72fe	63	32	specific	specific	JJ
cord-007726-bqlf72fe	63	33	moments	moment	NNS
cord-007726-bqlf72fe	63	34	in	in	IN
cord-007726-bqlf72fe	63	35	time	time	NN
cord-007726-bqlf72fe	63	36	.	.	.
cord-007726-bqlf72fe	64	1	However	however	RB
cord-007726-bqlf72fe	64	2	,	,	,
cord-007726-bqlf72fe	64	3	it	-PRON-	PRP
cord-007726-bqlf72fe	64	4	is	be	VBZ
cord-007726-bqlf72fe	64	5	important	important	JJ
cord-007726-bqlf72fe	64	6	to	to	TO
cord-007726-bqlf72fe	64	7	note	note	VB
cord-007726-bqlf72fe	64	8	that	that	DT
cord-007726-bqlf72fe	64	9	drift	drift	NN
cord-007726-bqlf72fe	64	10	between	between	IN
cord-007726-bqlf72fe	64	11	mouse	mouse	NN
cord-007726-bqlf72fe	64	12	colonies	colony	NNS
cord-007726-bqlf72fe	64	13	has	have	VBZ
cord-007726-bqlf72fe	64	14	long	long	RB
cord-007726-bqlf72fe	64	15	been	be	VBN
cord-007726-bqlf72fe	64	16	known	know	VBN
cord-007726-bqlf72fe	64	17	to	to	TO
cord-007726-bqlf72fe	64	18	occur	occur	VB
cord-007726-bqlf72fe	64	19	.	.	.
cord-007726-bqlf72fe	65	1	In	in	IN
cord-007726-bqlf72fe	65	2	fact	fact	NN
cord-007726-bqlf72fe	65	3	,	,	,
cord-007726-bqlf72fe	65	4	a	a	DT
cord-007726-bqlf72fe	65	5	recent	recent	JJ
cord-007726-bqlf72fe	65	6	report	report	NN
cord-007726-bqlf72fe	65	7	described	describe	VBD
cord-007726-bqlf72fe	65	8	the	the	DT
cord-007726-bqlf72fe	65	9	fortuitous	fortuitous	JJ
cord-007726-bqlf72fe	65	10	discovery	discovery	NN
cord-007726-bqlf72fe	65	11	of	of	IN
cord-007726-bqlf72fe	65	12	a	a	DT
cord-007726-bqlf72fe	65	13	point	point	NN
cord-007726-bqlf72fe	65	14	mutation	mutation	NN
cord-007726-bqlf72fe	65	15	in	in	IN
cord-007726-bqlf72fe	65	16	the	the	DT
cord-007726-bqlf72fe	65	17	natural	natural	JJ
cord-007726-bqlf72fe	65	18	cytotoxicity	cytotoxicity	NN
cord-007726-bqlf72fe	65	19	receptor	receptor	NN
cord-007726-bqlf72fe	65	20	1	1	CD
cord-007726-bqlf72fe	65	21	(	(	-LRB-
cord-007726-bqlf72fe	65	22	NCR1	NCR1	NNP
cord-007726-bqlf72fe	65	23	)	)	-RRB-
cord-007726-bqlf72fe	65	24	gene	gene	NN
cord-007726-bqlf72fe	65	25	in	in	IN
cord-007726-bqlf72fe	65	26	the	the	DT
cord-007726-bqlf72fe	65	27	C57	C57	NNP
cord-007726-bqlf72fe	65	28	/	/	SYM
cord-007726-bqlf72fe	65	29	Bl6	bl6	UH
cord-007726-bqlf72fe	65	30	CD45.1	cd45.1	NN
cord-007726-bqlf72fe	65	31	mouse	mouse	NN
cord-007726-bqlf72fe	65	32	strain	strain	NN
cord-007726-bqlf72fe	65	33	,	,	,
cord-007726-bqlf72fe	65	34	resulting	result	VBG
cord-007726-bqlf72fe	65	35	in	in	IN
cord-007726-bqlf72fe	65	36	absent	absent	JJ
cord-007726-bqlf72fe	65	37	NCR1	NCR1	NNP
cord-007726-bqlf72fe	65	38	expression	expression	NN
cord-007726-bqlf72fe	65	39	.	.	.
cord-007726-bqlf72fe	66	1	This	this	DT
cord-007726-bqlf72fe	66	2	mutation	mutation	NN
cord-007726-bqlf72fe	66	3	was	be	VBD
cord-007726-bqlf72fe	66	4	found	find	VBN
cord-007726-bqlf72fe	66	5	to	to	TO
cord-007726-bqlf72fe	66	6	have	have	VB
cord-007726-bqlf72fe	66	7	profound	profound	JJ
cord-007726-bqlf72fe	66	8	effects	effect	NNS
cord-007726-bqlf72fe	66	9	on	on	IN
cord-007726-bqlf72fe	66	10	the	the	DT
cord-007726-bqlf72fe	66	11	response	response	NN
cord-007726-bqlf72fe	66	12	of	of	IN
cord-007726-bqlf72fe	66	13	mice	mouse	NNS
cord-007726-bqlf72fe	66	14	to	to	IN
cord-007726-bqlf72fe	66	15	viral	viral	JJ
cord-007726-bqlf72fe	66	16	infection	infection	NN
cord-007726-bqlf72fe	66	17	,	,	,
cord-007726-bqlf72fe	66	18	i.e.	i.e.	FW
cord-007726-bqlf72fe	66	19	,	,	,
cord-007726-bqlf72fe	66	20	the	the	DT
cord-007726-bqlf72fe	66	21	mice	mouse	NNS
cord-007726-bqlf72fe	66	22	were	be	VBD
cord-007726-bqlf72fe	66	23	resistant	resistant	JJ
cord-007726-bqlf72fe	66	24	to	to	IN
cord-007726-bqlf72fe	66	25	cytomegalovirus	cytomegalovirus	JJ
cord-007726-bqlf72fe	66	26	infection	infection	NN
cord-007726-bqlf72fe	66	27	but	but	CC
cord-007726-bqlf72fe	66	28	more	more	RBR
cord-007726-bqlf72fe	66	29	susceptible	susceptible	JJ
cord-007726-bqlf72fe	66	30	to	to	IN
cord-007726-bqlf72fe	66	31	influenza	influenza	NN
cord-007726-bqlf72fe	66	32	virus	virus	NN
cord-007726-bqlf72fe	66	33	[	[	-LRB-
cord-007726-bqlf72fe	66	34	23	23	CD
cord-007726-bqlf72fe	66	35	]	]	-RRB-
cord-007726-bqlf72fe	66	36	.	.	.
cord-007726-bqlf72fe	67	1	This	this	DT
cord-007726-bqlf72fe	67	2	cautionary	cautionary	JJ
cord-007726-bqlf72fe	67	3	tale	tale	NN
cord-007726-bqlf72fe	67	4	highlights	highlight	VBZ
cord-007726-bqlf72fe	67	5	the	the	DT
cord-007726-bqlf72fe	67	6	importance	importance	NN
cord-007726-bqlf72fe	67	7	of	of	IN
cord-007726-bqlf72fe	67	8	understanding	understand	VBG
cord-007726-bqlf72fe	67	9	the	the	DT
cord-007726-bqlf72fe	67	10	genetic	genetic	JJ
cord-007726-bqlf72fe	67	11	evolution	evolution	NN
cord-007726-bqlf72fe	67	12	of	of	IN
cord-007726-bqlf72fe	67	13	laboratory	laboratory	NN
cord-007726-bqlf72fe	67	14	strains	strain	NNS
cord-007726-bqlf72fe	67	15	of	of	IN
cord-007726-bqlf72fe	67	16	mice	mouse	NNS
cord-007726-bqlf72fe	67	17	,	,	,
cord-007726-bqlf72fe	67	18	the	the	DT
cord-007726-bqlf72fe	67	19	effect	effect	NN
cord-007726-bqlf72fe	67	20	of	of	IN
cord-007726-bqlf72fe	67	21	these	these	DT
cord-007726-bqlf72fe	67	22	genetic	genetic	JJ
cord-007726-bqlf72fe	67	23	and	and	CC
cord-007726-bqlf72fe	67	24	immunological	immunological	JJ
cord-007726-bqlf72fe	67	25	changes	change	NNS
cord-007726-bqlf72fe	67	26	on	on	IN
cord-007726-bqlf72fe	67	27	mouse	mouse	NN
cord-007726-bqlf72fe	67	28	biology	biology	NN
cord-007726-bqlf72fe	67	29	,	,	,
cord-007726-bqlf72fe	67	30	and	and	CC
cord-007726-bqlf72fe	67	31	the	the	DT
cord-007726-bqlf72fe	67	32	impact	impact	NN
cord-007726-bqlf72fe	67	33	on	on	IN
cord-007726-bqlf72fe	67	34	the	the	DT
cord-007726-bqlf72fe	67	35	translation	translation	NN
cord-007726-bqlf72fe	67	36	of	of	IN
cord-007726-bqlf72fe	67	37	these	these	DT
cord-007726-bqlf72fe	67	38	results	result	NNS
cord-007726-bqlf72fe	67	39	to	to	IN
cord-007726-bqlf72fe	67	40	human	human	JJ
cord-007726-bqlf72fe	67	41	medicine	medicine	NN
cord-007726-bqlf72fe	67	42	.	.	.
cord-007726-bqlf72fe	68	1	In	in	IN
cord-007726-bqlf72fe	68	2	addition	addition	NN
cord-007726-bqlf72fe	68	3	to	to	IN
cord-007726-bqlf72fe	68	4	the	the	DT
cord-007726-bqlf72fe	68	5	differences	difference	NNS
cord-007726-bqlf72fe	68	6	between	between	IN
cord-007726-bqlf72fe	68	7	mouse	mouse	NN
cord-007726-bqlf72fe	68	8	and	and	CC
cord-007726-bqlf72fe	68	9	human	human	JJ
cord-007726-bqlf72fe	68	10	genetics	genetic	NNS
cord-007726-bqlf72fe	68	11	,	,	,
cord-007726-bqlf72fe	68	12	physiology	physiology	NN
cord-007726-bqlf72fe	68	13	,	,	,
cord-007726-bqlf72fe	68	14	and	and	CC
cord-007726-bqlf72fe	68	15	immunology	immunology	NN
cord-007726-bqlf72fe	68	16	highlighted	highlight	VBN
cord-007726-bqlf72fe	68	17	above	above	RB
cord-007726-bqlf72fe	68	18	,	,	,
cord-007726-bqlf72fe	68	19	several	several	JJ
cord-007726-bqlf72fe	68	20	factors	factor	NNS
cord-007726-bqlf72fe	68	21	must	must	MD
cord-007726-bqlf72fe	68	22	also	also	RB
cord-007726-bqlf72fe	68	23	be	be	VB
cord-007726-bqlf72fe	68	24	taken	take	VBN
cord-007726-bqlf72fe	68	25	into	into	IN
cord-007726-bqlf72fe	68	26	account	account	NN
cord-007726-bqlf72fe	68	27	when	when	WRB
cord-007726-bqlf72fe	68	28	performing	perform	VBG
cord-007726-bqlf72fe	68	29	in	in	IN
cord-007726-bqlf72fe	68	30	vitro	vitro	FW
cord-007726-bqlf72fe	68	31	assays	assay	NNS
cord-007726-bqlf72fe	68	32	using	use	VBG
cord-007726-bqlf72fe	68	33	isolated	isolate	VBN
cord-007726-bqlf72fe	68	34	mouse	mouse	NN
cord-007726-bqlf72fe	68	35	cells	cell	NNS
cord-007726-bqlf72fe	68	36	and	and	CC
cord-007726-bqlf72fe	68	37	applying	apply	VBG
cord-007726-bqlf72fe	68	38	these	these	DT
cord-007726-bqlf72fe	68	39	findings	finding	NNS
cord-007726-bqlf72fe	68	40	to	to	IN
cord-007726-bqlf72fe	68	41	our	-PRON-	PRP$
cord-007726-bqlf72fe	68	42	understanding	understanding	NN
cord-007726-bqlf72fe	68	43	of	of	IN
cord-007726-bqlf72fe	68	44	human	human	JJ
cord-007726-bqlf72fe	68	45	disease	disease	NN
cord-007726-bqlf72fe	68	46	.	.	.
cord-007726-bqlf72fe	69	1	Particularly	particularly	RB
cord-007726-bqlf72fe	69	2	with	with	IN
cord-007726-bqlf72fe	69	3	regard	regard	NN
cord-007726-bqlf72fe	69	4	to	to	IN
cord-007726-bqlf72fe	69	5	stem	stem	VB
cord-007726-bqlf72fe	69	6	cell	cell	NN
cord-007726-bqlf72fe	69	7	research	research	NN
cord-007726-bqlf72fe	69	8	,	,	,
cord-007726-bqlf72fe	69	9	it	-PRON-	PRP
cord-007726-bqlf72fe	69	10	should	should	MD
cord-007726-bqlf72fe	69	11	be	be	VB
cord-007726-bqlf72fe	69	12	noted	note	VBN
cord-007726-bqlf72fe	69	13	that	that	IN
cord-007726-bqlf72fe	69	14	the	the	DT
cord-007726-bqlf72fe	69	15	telomeres	telomere	NNS
cord-007726-bqlf72fe	69	16	of	of	IN
cord-007726-bqlf72fe	69	17	mouse	mouse	NN
cord-007726-bqlf72fe	69	18	cells	cell	NNS
cord-007726-bqlf72fe	69	19	are	be	VBP
cord-007726-bqlf72fe	69	20	five	five	CD
cord-007726-bqlf72fe	69	21	-	-	:
cord-007726-bqlf72fe	69	22	to	to	IN
cord-007726-bqlf72fe	69	23	tenfold	tenfold	RB
cord-007726-bqlf72fe	69	24	longer	long	RBR
cord-007726-bqlf72fe	69	25	than	than	IN
cord-007726-bqlf72fe	69	26	human	human	JJ
cord-007726-bqlf72fe	69	27	telomeres	telomere	NNS
cord-007726-bqlf72fe	69	28	,	,	,
cord-007726-bqlf72fe	69	29	resulting	result	VBG
cord-007726-bqlf72fe	69	30	in	in	IN
cord-007726-bqlf72fe	69	31	greater	great	JJR
cord-007726-bqlf72fe	69	32	replicative	replicative	JJ
cord-007726-bqlf72fe	69	33	capacity	capacity	NN
cord-007726-bqlf72fe	69	34	[	[	-LRB-
cord-007726-bqlf72fe	69	35	24	24	CD
cord-007726-bqlf72fe	69	36	]	]	-RRB-
cord-007726-bqlf72fe	69	37	.	.	.
cord-007726-bqlf72fe	70	1	There	there	EX
cord-007726-bqlf72fe	70	2	are	be	VBP
cord-007726-bqlf72fe	70	3	also	also	RB
cord-007726-bqlf72fe	70	4	important	important	JJ
cord-007726-bqlf72fe	70	5	differences	difference	NNS
cord-007726-bqlf72fe	70	6	in	in	IN
cord-007726-bqlf72fe	70	7	the	the	DT
cord-007726-bqlf72fe	70	8	regulation	regulation	NN
cord-007726-bqlf72fe	70	9	of	of	IN
cord-007726-bqlf72fe	70	10	pluripotency	pluripotency	NN
cord-007726-bqlf72fe	70	11	and	and	CC
cord-007726-bqlf72fe	70	12	stem	stem	NN
cord-007726-bqlf72fe	70	13	cell	cell	NN
cord-007726-bqlf72fe	70	14	differentiation	differentiation	NN
cord-007726-bqlf72fe	70	15	pathways	pathway	NNS
cord-007726-bqlf72fe	70	16	in	in	IN
cord-007726-bqlf72fe	70	17	humans	human	NNS
cord-007726-bqlf72fe	70	18	and	and	CC
cord-007726-bqlf72fe	70	19	mice	mouse	NNS
cord-007726-bqlf72fe	70	20	[	[	-LRB-
cord-007726-bqlf72fe	70	21	25	25	CD
cord-007726-bqlf72fe	70	22	]	]	-RRB-
cord-007726-bqlf72fe	70	23	.	.	.
cord-007726-bqlf72fe	71	1	Moreover	moreover	RB
cord-007726-bqlf72fe	71	2	,	,	,
cord-007726-bqlf72fe	71	3	there	there	EX
cord-007726-bqlf72fe	71	4	are	be	VBP
cord-007726-bqlf72fe	71	5	considerable	considerable	JJ
cord-007726-bqlf72fe	71	6	species	specie	NNS
cord-007726-bqlf72fe	71	7	differences	difference	NNS
cord-007726-bqlf72fe	71	8	in	in	IN
cord-007726-bqlf72fe	71	9	the	the	DT
cord-007726-bqlf72fe	71	10	longevity	longevity	NN
cord-007726-bqlf72fe	71	11	of	of	IN
cord-007726-bqlf72fe	71	12	cultured	cultured	JJ
cord-007726-bqlf72fe	71	13	cells	cell	NNS
cord-007726-bqlf72fe	71	14	;	;	:
cord-007726-bqlf72fe	71	15	for	for	IN
cord-007726-bqlf72fe	71	16	example	example	NN
cord-007726-bqlf72fe	71	17	,	,	,
cord-007726-bqlf72fe	71	18	mouse	mouse	NN
cord-007726-bqlf72fe	71	19	fibroblasts	fibroblast	NNS
cord-007726-bqlf72fe	71	20	are	be	VBP
cord-007726-bqlf72fe	71	21	capable	capable	JJ
cord-007726-bqlf72fe	71	22	of	of	IN
cord-007726-bqlf72fe	71	23	spontaneous	spontaneous	JJ
cord-007726-bqlf72fe	71	24	immortalization	immortalization	NN
cord-007726-bqlf72fe	71	25	in	in	IN
cord-007726-bqlf72fe	71	26	vitro	vitro	FW
cord-007726-bqlf72fe	71	27	,	,	,
cord-007726-bqlf72fe	71	28	whereas	whereas	IN
cord-007726-bqlf72fe	71	29	human	human	JJ
cord-007726-bqlf72fe	71	30	fibroblasts	fibroblast	NNS
cord-007726-bqlf72fe	71	31	become	become	VBP
cord-007726-bqlf72fe	71	32	senescent	senescent	JJ
cord-007726-bqlf72fe	71	33	and	and	CC
cord-007726-bqlf72fe	71	34	ultimately	ultimately	RB
cord-007726-bqlf72fe	71	35	fail	fail	VBP
cord-007726-bqlf72fe	71	36	to	to	TO
cord-007726-bqlf72fe	71	37	thrive	thrive	VB
cord-007726-bqlf72fe	71	38	in	in	IN
cord-007726-bqlf72fe	71	39	culture	culture	NN
cord-007726-bqlf72fe	71	40	[	[	-LRB-
cord-007726-bqlf72fe	71	41	26	26	CD
cord-007726-bqlf72fe	71	42	]	]	-RRB-
cord-007726-bqlf72fe	71	43	.	.	.
cord-007726-bqlf72fe	72	1	In	in	IN
cord-007726-bqlf72fe	72	2	summary	summary	NN
cord-007726-bqlf72fe	72	3	,	,	,
cord-007726-bqlf72fe	72	4	although	although	IN
cord-007726-bqlf72fe	72	5	there	there	EX
cord-007726-bqlf72fe	72	6	are	be	VBP
cord-007726-bqlf72fe	72	7	considerable	considerable	JJ
cord-007726-bqlf72fe	72	8	differences	difference	NNS
cord-007726-bqlf72fe	72	9	between	between	IN
cord-007726-bqlf72fe	72	10	mice	mouse	NNS
cord-007726-bqlf72fe	72	11	and	and	CC
cord-007726-bqlf72fe	72	12	humans	human	NNS
cord-007726-bqlf72fe	72	13	,	,	,
cord-007726-bqlf72fe	72	14	constant	constant	JJ
cord-007726-bqlf72fe	72	15	improvement	improvement	NN
cord-007726-bqlf72fe	72	16	in	in	IN
cord-007726-bqlf72fe	72	17	the	the	DT
cord-007726-bqlf72fe	72	18	analytical	analytical	JJ
cord-007726-bqlf72fe	72	19	techniques	technique	NNS
cord-007726-bqlf72fe	72	20	used	use	VBN
cord-007726-bqlf72fe	72	21	to	to	TO
cord-007726-bqlf72fe	72	22	delineate	delineate	VB
cord-007726-bqlf72fe	72	23	these	these	DT
cord-007726-bqlf72fe	72	24	differences	difference	NNS
cord-007726-bqlf72fe	72	25	and	and	CC
cord-007726-bqlf72fe	72	26	their	-PRON-	PRP$
cord-007726-bqlf72fe	72	27	effects	effect	NNS
cord-007726-bqlf72fe	72	28	on	on	IN
cord-007726-bqlf72fe	72	29	whole	whole	JJ
cord-007726-bqlf72fe	72	30	organism	organism	NN
cord-007726-bqlf72fe	72	31	and	and	CC
cord-007726-bqlf72fe	72	32	cell	cell	NN
cord-007726-bqlf72fe	72	33	function	function	NN
cord-007726-bqlf72fe	72	34	have	have	VBP
cord-007726-bqlf72fe	72	35	provided	provide	VBN
cord-007726-bqlf72fe	72	36	vital	vital	JJ
cord-007726-bqlf72fe	72	37	information	information	NN
cord-007726-bqlf72fe	72	38	and	and	CC
cord-007726-bqlf72fe	72	39	contributed	contribute	VBD
cord-007726-bqlf72fe	72	40	to	to	IN
cord-007726-bqlf72fe	72	41	our	-PRON-	PRP$
cord-007726-bqlf72fe	72	42	understanding	understanding	NN
cord-007726-bqlf72fe	72	43	of	of	IN
cord-007726-bqlf72fe	72	44	both	both	CC
cord-007726-bqlf72fe	72	45	murine	murine	JJ
cord-007726-bqlf72fe	72	46	and	and	CC
cord-007726-bqlf72fe	72	47	human	human	JJ
cord-007726-bqlf72fe	72	48	biology	biology	NN
cord-007726-bqlf72fe	72	49	.	.	.
cord-007726-bqlf72fe	73	1	Experimentation	experimentation	NN
cord-007726-bqlf72fe	73	2	employing	employ	VBG
cord-007726-bqlf72fe	73	3	mouse	mouse	NN
cord-007726-bqlf72fe	73	4	models	model	NNS
cord-007726-bqlf72fe	73	5	of	of	IN
cord-007726-bqlf72fe	73	6	human	human	JJ
cord-007726-bqlf72fe	73	7	disease	disease	NN
cord-007726-bqlf72fe	73	8	will	will	MD
cord-007726-bqlf72fe	73	9	continue	continue	VB
cord-007726-bqlf72fe	73	10	to	to	TO
cord-007726-bqlf72fe	73	11	provide	provide	VB
cord-007726-bqlf72fe	73	12	key	key	JJ
cord-007726-bqlf72fe	73	13	insights	insight	NNS
cord-007726-bqlf72fe	73	14	into	into	IN
cord-007726-bqlf72fe	73	15	relevant	relevant	JJ
cord-007726-bqlf72fe	73	16	disease	disease	NN
cord-007726-bqlf72fe	73	17	mechanisms	mechanism	NNS
cord-007726-bqlf72fe	73	18	and	and	CC
cord-007726-bqlf72fe	73	19	potential	potential	JJ
cord-007726-bqlf72fe	73	20	drug	drug	NN
cord-007726-bqlf72fe	73	21	targets	target	NNS
cord-007726-bqlf72fe	73	22	for	for	IN
cord-007726-bqlf72fe	73	23	further	further	JJ
cord-007726-bqlf72fe	73	24	clinical	clinical	JJ
cord-007726-bqlf72fe	73	25	investigation	investigation	NN
cord-007726-bqlf72fe	73	26	.	.	.
cord-007726-bqlf72fe	74	1	However	however	RB
cord-007726-bqlf72fe	74	2	,	,	,
cord-007726-bqlf72fe	74	3	several	several	JJ
cord-007726-bqlf72fe	74	4	important	important	JJ
cord-007726-bqlf72fe	74	5	considerations	consideration	NNS
cord-007726-bqlf72fe	74	6	must	must	MD
cord-007726-bqlf72fe	74	7	be	be	VB
cord-007726-bqlf72fe	74	8	taken	take	VBN
cord-007726-bqlf72fe	74	9	into	into	IN
cord-007726-bqlf72fe	74	10	account	account	NN
cord-007726-bqlf72fe	74	11	when	when	WRB
cord-007726-bqlf72fe	74	12	selecting	select	VBG
cord-007726-bqlf72fe	74	13	a	a	DT
cord-007726-bqlf72fe	74	14	mouse	mouse	NN
cord-007726-bqlf72fe	74	15	model	model	NN
cord-007726-bqlf72fe	74	16	of	of	IN
cord-007726-bqlf72fe	74	17	human	human	JJ
cord-007726-bqlf72fe	74	18	disease	disease	NN
cord-007726-bqlf72fe	74	19	,	,	,
cord-007726-bqlf72fe	74	20	as	as	IN
cord-007726-bqlf72fe	74	21	described	describe	VBN
cord-007726-bqlf72fe	74	22	in	in	IN
cord-007726-bqlf72fe	74	23	the	the	DT
cord-007726-bqlf72fe	74	24	following	follow	VBG
cord-007726-bqlf72fe	74	25	section	section	NN
cord-007726-bqlf72fe	74	26	,	,	,
cord-007726-bqlf72fe	74	27	using	use	VBG
cord-007726-bqlf72fe	74	28	mouse	mouse	NN
cord-007726-bqlf72fe	74	29	models	model	NNS
cord-007726-bqlf72fe	74	30	of	of	IN
cord-007726-bqlf72fe	74	31	human	human	JJ
cord-007726-bqlf72fe	74	32	lung	lung	NN
cord-007726-bqlf72fe	74	33	disease	disease	NN
cord-007726-bqlf72fe	74	34	to	to	TO
cord-007726-bqlf72fe	74	35	illustrate	illustrate	VB
cord-007726-bqlf72fe	74	36	this	this	DT
cord-007726-bqlf72fe	74	37	point	point	NN
cord-007726-bqlf72fe	74	38	.	.	.
cord-007726-bqlf72fe	75	1	The	the	DT
cord-007726-bqlf72fe	75	2	two	two	CD
cord-007726-bqlf72fe	75	3	most	most	RBS
cord-007726-bqlf72fe	75	4	salient	salient	JJ
cord-007726-bqlf72fe	75	5	features	feature	NNS
cord-007726-bqlf72fe	75	6	of	of	IN
cord-007726-bqlf72fe	75	7	a	a	DT
cord-007726-bqlf72fe	75	8	mouse	mouse	NN
cord-007726-bqlf72fe	75	9	model	model	NN
cord-007726-bqlf72fe	75	10	of	of	IN
cord-007726-bqlf72fe	75	11	human	human	JJ
cord-007726-bqlf72fe	75	12	disease	disease	NN
cord-007726-bqlf72fe	75	13	are	be	VBP
cord-007726-bqlf72fe	75	14	the	the	DT
cord-007726-bqlf72fe	75	15	accuracy	accuracy	NN
cord-007726-bqlf72fe	75	16	of	of	IN
cord-007726-bqlf72fe	75	17	its	-PRON-	PRP$
cord-007726-bqlf72fe	75	18	etiology	etiology	NN
cord-007726-bqlf72fe	75	19	(	(	-LRB-
cord-007726-bqlf72fe	75	20	it	-PRON-	PRP
cord-007726-bqlf72fe	75	21	employs	employ	VBZ
cord-007726-bqlf72fe	75	22	a	a	DT
cord-007726-bqlf72fe	75	23	physiologically	physiologically	RB
cord-007726-bqlf72fe	75	24	relevant	relevant	JJ
cord-007726-bqlf72fe	75	25	method	method	NN
cord-007726-bqlf72fe	75	26	of	of	IN
cord-007726-bqlf72fe	75	27	disease	disease	NN
cord-007726-bqlf72fe	75	28	induction	induction	NN
cord-007726-bqlf72fe	75	29	)	)	-RRB-
cord-007726-bqlf72fe	75	30	and	and	CC
cord-007726-bqlf72fe	75	31	its	-PRON-	PRP$
cord-007726-bqlf72fe	75	32	presentation	presentation	NN
cord-007726-bqlf72fe	75	33	(	(	-LRB-
cord-007726-bqlf72fe	75	34	its	-PRON-	PRP$
cord-007726-bqlf72fe	75	35	ability	ability	NN
cord-007726-bqlf72fe	75	36	to	to	TO
cord-007726-bqlf72fe	75	37	recapitulate	recapitulate	VB
cord-007726-bqlf72fe	75	38	the	the	DT
cord-007726-bqlf72fe	75	39	features	feature	NNS
cord-007726-bqlf72fe	75	40	of	of	IN
cord-007726-bqlf72fe	75	41	human	human	JJ
cord-007726-bqlf72fe	75	42	disease	disease	NN
cord-007726-bqlf72fe	75	43	)	)	-RRB-
cord-007726-bqlf72fe	75	44	.	.	.
cord-007726-bqlf72fe	76	1	The	the	DT
cord-007726-bqlf72fe	76	2	relevance	relevance	NN
cord-007726-bqlf72fe	76	3	of	of	IN
cord-007726-bqlf72fe	76	4	any	any	DT
cord-007726-bqlf72fe	76	5	given	give	VBN
cord-007726-bqlf72fe	76	6	mouse	mouse	NN
cord-007726-bqlf72fe	76	7	model	model	NN
cord-007726-bqlf72fe	76	8	can	can	MD
cord-007726-bqlf72fe	76	9	be	be	VB
cord-007726-bqlf72fe	76	10	judged	judge	VBN
cord-007726-bqlf72fe	76	11	on	on	IN
cord-007726-bqlf72fe	76	12	the	the	DT
cord-007726-bqlf72fe	76	13	basis	basis	NN
cord-007726-bqlf72fe	76	14	of	of	IN
cord-007726-bqlf72fe	76	15	these	these	DT
cord-007726-bqlf72fe	76	16	two	two	CD
cord-007726-bqlf72fe	76	17	criteria	criterion	NNS
cord-007726-bqlf72fe	76	18	,	,	,
cord-007726-bqlf72fe	76	19	and	and	CC
cord-007726-bqlf72fe	76	20	there	there	EX
cord-007726-bqlf72fe	76	21	is	be	VBZ
cord-007726-bqlf72fe	76	22	considerable	considerable	JJ
cord-007726-bqlf72fe	76	23	variation	variation	NN
cord-007726-bqlf72fe	76	24	within	within	IN
cord-007726-bqlf72fe	76	25	mouse	mouse	NN
cord-007726-bqlf72fe	76	26	models	model	NNS
cord-007726-bqlf72fe	76	27	of	of	IN
cord-007726-bqlf72fe	76	28	human	human	JJ
cord-007726-bqlf72fe	76	29	disease	disease	NN
cord-007726-bqlf72fe	76	30	in	in	IN
cord-007726-bqlf72fe	76	31	this	this	DT
cord-007726-bqlf72fe	76	32	regard	regard	NN
cord-007726-bqlf72fe	76	33	.	.	.
cord-007726-bqlf72fe	77	1	As	as	IN
cord-007726-bqlf72fe	77	2	a	a	DT
cord-007726-bqlf72fe	77	3	full	full	JJ
cord-007726-bqlf72fe	77	4	assessment	assessment	NN
cord-007726-bqlf72fe	77	5	of	of	IN
cord-007726-bqlf72fe	77	6	the	the	DT
cord-007726-bqlf72fe	77	7	advantages	advantage	NNS
cord-007726-bqlf72fe	77	8	and	and	CC
cord-007726-bqlf72fe	77	9	limitations	limitation	NNS
cord-007726-bqlf72fe	77	10	of	of	IN
cord-007726-bqlf72fe	77	11	all	all	DT
cord-007726-bqlf72fe	77	12	currently	currently	RB
cord-007726-bqlf72fe	77	13	available	available	JJ
cord-007726-bqlf72fe	77	14	mouse	mouse	NN
cord-007726-bqlf72fe	77	15	models	model	NNS
cord-007726-bqlf72fe	77	16	of	of	IN
cord-007726-bqlf72fe	77	17	human	human	JJ
cord-007726-bqlf72fe	77	18	disease	disease	NN
cord-007726-bqlf72fe	77	19	would	would	MD
cord-007726-bqlf72fe	77	20	be	be	VB
cord-007726-bqlf72fe	77	21	prohibitively	prohibitively	RB
cord-007726-bqlf72fe	77	22	long	long	JJ
cord-007726-bqlf72fe	77	23	and	and	CC
cord-007726-bqlf72fe	77	24	complex	complex	JJ
cord-007726-bqlf72fe	77	25	,	,	,
cord-007726-bqlf72fe	77	26	here	here	RB
cord-007726-bqlf72fe	77	27	we	-PRON-	PRP
cord-007726-bqlf72fe	77	28	have	have	VBP
cord-007726-bqlf72fe	77	29	elected	elect	VBN
cord-007726-bqlf72fe	77	30	to	to	TO
cord-007726-bqlf72fe	77	31	assess	assess	VB
cord-007726-bqlf72fe	77	32	the	the	DT
cord-007726-bqlf72fe	77	33	accuracy	accuracy	NN
cord-007726-bqlf72fe	77	34	of	of	IN
cord-007726-bqlf72fe	77	35	currently	currently	RB
cord-007726-bqlf72fe	77	36	available	available	JJ
cord-007726-bqlf72fe	77	37	models	model	NNS
cord-007726-bqlf72fe	77	38	of	of	IN
cord-007726-bqlf72fe	77	39	human	human	JJ
cord-007726-bqlf72fe	77	40	lung	lung	NN
cord-007726-bqlf72fe	77	41	diseases	disease	NNS
cord-007726-bqlf72fe	77	42	,	,	,
cord-007726-bqlf72fe	77	43	i.e.	i.e.	FW
cord-007726-bqlf72fe	77	44	,	,	,
cord-007726-bqlf72fe	77	45	asthma	asthma	NN
cord-007726-bqlf72fe	77	46	,	,	,
cord-007726-bqlf72fe	77	47	chronic	chronic	JJ
cord-007726-bqlf72fe	77	48	obstructive	obstructive	JJ
cord-007726-bqlf72fe	77	49	pulmonary	pulmonary	JJ
cord-007726-bqlf72fe	77	50	disease	disease	NN
cord-007726-bqlf72fe	77	51	,	,	,
cord-007726-bqlf72fe	77	52	and	and	CC
cord-007726-bqlf72fe	77	53	pulmonary	pulmonary	JJ
cord-007726-bqlf72fe	77	54	fibrosis	fibrosis	NN
cord-007726-bqlf72fe	77	55	,	,	,
cord-007726-bqlf72fe	77	56	focusing	focus	VBG
cord-007726-bqlf72fe	77	57	on	on	IN
cord-007726-bqlf72fe	77	58	the	the	DT
cord-007726-bqlf72fe	77	59	relevance	relevance	NN
cord-007726-bqlf72fe	77	60	of	of	IN
cord-007726-bqlf72fe	77	61	disease	disease	NN
cord-007726-bqlf72fe	77	62	induction	induction	NN
cord-007726-bqlf72fe	77	63	in	in	IN
cord-007726-bqlf72fe	77	64	these	these	DT
cord-007726-bqlf72fe	77	65	models	model	NNS
cord-007726-bqlf72fe	77	66	and	and	CC
cord-007726-bqlf72fe	77	67	their	-PRON-	PRP$
cord-007726-bqlf72fe	77	68	ability	ability	NN
cord-007726-bqlf72fe	77	69	to	to	TO
cord-007726-bqlf72fe	77	70	replicate	replicate	VB
cord-007726-bqlf72fe	77	71	critical	critical	JJ
cord-007726-bqlf72fe	77	72	features	feature	NNS
cord-007726-bqlf72fe	77	73	of	of	IN
cord-007726-bqlf72fe	77	74	human	human	JJ
cord-007726-bqlf72fe	77	75	disease	disease	NN
cord-007726-bqlf72fe	77	76	pathophysiology	pathophysiology	NN
cord-007726-bqlf72fe	77	77	and	and	CC
cord-007726-bqlf72fe	77	78	response	response	NN
cord-007726-bqlf72fe	77	79	to	to	IN
cord-007726-bqlf72fe	77	80	treatment	treatment	NN
cord-007726-bqlf72fe	77	81	.	.	.
cord-007726-bqlf72fe	78	1	The	the	DT
cord-007726-bqlf72fe	78	2	first	first	JJ
cord-007726-bqlf72fe	78	3	and	and	CC
cord-007726-bqlf72fe	78	4	foremost	foremost	RB
cord-007726-bqlf72fe	78	5	notion	notion	NN
cord-007726-bqlf72fe	78	6	when	when	WRB
cord-007726-bqlf72fe	78	7	modeling	model	VBG
cord-007726-bqlf72fe	78	8	human	human	JJ
cord-007726-bqlf72fe	78	9	disease	disease	NN
cord-007726-bqlf72fe	78	10	in	in	IN
cord-007726-bqlf72fe	78	11	mice	mice	NN
cord-007726-bqlf72fe	78	12	is	be	VBZ
cord-007726-bqlf72fe	78	13	to	to	TO
cord-007726-bqlf72fe	78	14	acknowledge	acknowledge	VB
cord-007726-bqlf72fe	78	15	the	the	DT
cord-007726-bqlf72fe	78	16	species	specie	NNS
cord-007726-bqlf72fe	78	17	differences	difference	NNS
cord-007726-bqlf72fe	78	18	,	,	,
cord-007726-bqlf72fe	78	19	which	which	WDT
cord-007726-bqlf72fe	78	20	are	be	VBP
cord-007726-bqlf72fe	78	21	significant	significant	JJ
cord-007726-bqlf72fe	78	22	[	[	-LRB-
cord-007726-bqlf72fe	78	23	27	27	CD
cord-007726-bqlf72fe	78	24	]	]	-RRB-
cord-007726-bqlf72fe	78	25	.	.	.
cord-007726-bqlf72fe	79	1	As	as	IN
cord-007726-bqlf72fe	79	2	described	describe	VBN
cord-007726-bqlf72fe	79	3	above	above	RB
cord-007726-bqlf72fe	79	4	,	,	,
cord-007726-bqlf72fe	79	5	genetics	genetics	NN
cord-007726-bqlf72fe	79	6	,	,	,
cord-007726-bqlf72fe	79	7	anatomy	anatomy	NN
cord-007726-bqlf72fe	79	8	,	,	,
cord-007726-bqlf72fe	79	9	physiology	physiology	NN
cord-007726-bqlf72fe	79	10	,	,	,
cord-007726-bqlf72fe	79	11	and	and	CC
cord-007726-bqlf72fe	79	12	immunology	immunology	NN
cord-007726-bqlf72fe	79	13	differ	differ	VBP
cord-007726-bqlf72fe	79	14	between	between	IN
cord-007726-bqlf72fe	79	15	mice	mouse	NNS
cord-007726-bqlf72fe	79	16	and	and	CC
cord-007726-bqlf72fe	79	17	humans	human	NNS
cord-007726-bqlf72fe	79	18	,	,	,
cord-007726-bqlf72fe	79	19	but	but	CC
cord-007726-bqlf72fe	79	20	despite	despite	IN
cord-007726-bqlf72fe	79	21	these	these	DT
cord-007726-bqlf72fe	79	22	differences	difference	NNS
cord-007726-bqlf72fe	79	23	,	,	,
cord-007726-bqlf72fe	79	24	mouse	mouse	NN
cord-007726-bqlf72fe	79	25	models	model	NNS
cord-007726-bqlf72fe	79	26	of	of	IN
cord-007726-bqlf72fe	79	27	human	human	JJ
cord-007726-bqlf72fe	79	28	disease	disease	NN
cord-007726-bqlf72fe	79	29	are	be	VBP
cord-007726-bqlf72fe	79	30	useful	useful	JJ
cord-007726-bqlf72fe	79	31	and	and	CC
cord-007726-bqlf72fe	79	32	necessary	necessary	JJ
cord-007726-bqlf72fe	79	33	,	,	,
cord-007726-bqlf72fe	79	34	as	as	RB
cord-007726-bqlf72fe	79	35	long	long	RB
cord-007726-bqlf72fe	79	36	as	as	IN
cord-007726-bqlf72fe	79	37	data	datum	NNS
cord-007726-bqlf72fe	79	38	interpretation	interpretation	NN
cord-007726-bqlf72fe	79	39	is	be	VBZ
cord-007726-bqlf72fe	79	40	performed	perform	VBN
cord-007726-bqlf72fe	79	41	appropriately	appropriately	RB
cord-007726-bqlf72fe	79	42	.	.	.
cord-007726-bqlf72fe	80	1	An	an	DT
cord-007726-bqlf72fe	80	2	elegant	elegant	JJ
cord-007726-bqlf72fe	80	3	example	example	NN
cord-007726-bqlf72fe	80	4	of	of	IN
cord-007726-bqlf72fe	80	5	differences	difference	NNS
cord-007726-bqlf72fe	80	6	between	between	IN
cord-007726-bqlf72fe	80	7	mice	mouse	NNS
cord-007726-bqlf72fe	80	8	and	and	CC
cord-007726-bqlf72fe	80	9	humans	human	NNS
cord-007726-bqlf72fe	80	10	that	that	WDT
cord-007726-bqlf72fe	80	11	must	must	MD
cord-007726-bqlf72fe	80	12	be	be	VB
cord-007726-bqlf72fe	80	13	considered	consider	VBN
cord-007726-bqlf72fe	80	14	when	when	WRB
cord-007726-bqlf72fe	80	15	designing	design	VBG
cord-007726-bqlf72fe	80	16	a	a	DT
cord-007726-bqlf72fe	80	17	mouse	mouse	NN
cord-007726-bqlf72fe	80	18	model	model	NN
cord-007726-bqlf72fe	80	19	of	of	IN
cord-007726-bqlf72fe	80	20	human	human	JJ
cord-007726-bqlf72fe	80	21	inflammatory	inflammatory	JJ
cord-007726-bqlf72fe	80	22	lung	lung	NN
cord-007726-bqlf72fe	80	23	disease	disease	NN
cord-007726-bqlf72fe	80	24	is	be	VBZ
cord-007726-bqlf72fe	80	25	the	the	DT
cord-007726-bqlf72fe	80	26	key	key	JJ
cord-007726-bqlf72fe	80	27	effector	effector	NN
cord-007726-bqlf72fe	80	28	cell	cell	NN
cord-007726-bqlf72fe	80	29	type	type	NN
cord-007726-bqlf72fe	80	30	in	in	IN
cord-007726-bqlf72fe	80	31	human	human	JJ
cord-007726-bqlf72fe	80	32	asthma	asthma	NN
cord-007726-bqlf72fe	80	33	,	,	,
cord-007726-bqlf72fe	80	34	i.e.	i.e.	FW
cord-007726-bqlf72fe	80	35	,	,	,
cord-007726-bqlf72fe	80	36	mast	mast	NN
cord-007726-bqlf72fe	80	37	cells	cell	NNS
cord-007726-bqlf72fe	80	38	.	.	.
cord-007726-bqlf72fe	81	1	These	these	DT
cord-007726-bqlf72fe	81	2	leukocytes	leukocyte	NNS
cord-007726-bqlf72fe	81	3	differ	differ	VBP
cord-007726-bqlf72fe	81	4	in	in	IN
cord-007726-bqlf72fe	81	5	granule	granule	NN
cord-007726-bqlf72fe	81	6	composition	composition	NN
cord-007726-bqlf72fe	81	7	as	as	RB
cord-007726-bqlf72fe	81	8	well	well	RB
cord-007726-bqlf72fe	81	9	as	as	IN
cord-007726-bqlf72fe	81	10	localization	localization	NN
cord-007726-bqlf72fe	81	11	in	in	IN
cord-007726-bqlf72fe	81	12	the	the	DT
cord-007726-bqlf72fe	81	13	mouse	mouse	NN
cord-007726-bqlf72fe	81	14	and	and	CC
cord-007726-bqlf72fe	81	15	human	human	JJ
cord-007726-bqlf72fe	81	16	airways	airways	NNPS
cord-007726-bqlf72fe	81	17	[	[	-LRB-
cord-007726-bqlf72fe	81	18	28	28	CD
cord-007726-bqlf72fe	81	19	]	]	-RRB-
cord-007726-bqlf72fe	81	20	.	.	.
cord-007726-bqlf72fe	82	1	Mice	mouse	NNS
cord-007726-bqlf72fe	82	2	mostly	mostly	RB
cord-007726-bqlf72fe	82	3	lack	lack	VBP
cord-007726-bqlf72fe	82	4	mast	mast	NN
cord-007726-bqlf72fe	82	5	cells	cell	NNS
cord-007726-bqlf72fe	82	6	in	in	IN
cord-007726-bqlf72fe	82	7	the	the	DT
cord-007726-bqlf72fe	82	8	peripheral	peripheral	JJ
cord-007726-bqlf72fe	82	9	lung	lung	NN
cord-007726-bqlf72fe	82	10	[	[	-LRB-
cord-007726-bqlf72fe	82	11	29	29	CD
cord-007726-bqlf72fe	82	12	]	]	-RRB-
cord-007726-bqlf72fe	82	13	,	,	,
cord-007726-bqlf72fe	82	14	whereas	whereas	IN
cord-007726-bqlf72fe	82	15	humans	human	NNS
cord-007726-bqlf72fe	82	16	have	have	VBP
cord-007726-bqlf72fe	82	17	numerous	numerous	JJ
cord-007726-bqlf72fe	82	18	mast	mast	JJ
cord-007726-bqlf72fe	82	19	cells	cell	NNS
cord-007726-bqlf72fe	82	20	of	of	IN
cord-007726-bqlf72fe	82	21	multiple	multiple	JJ
cord-007726-bqlf72fe	82	22	subpopulations	subpopulation	NNS
cord-007726-bqlf72fe	82	23	in	in	IN
cord-007726-bqlf72fe	82	24	the	the	DT
cord-007726-bqlf72fe	82	25	alveolar	alveolar	JJ
cord-007726-bqlf72fe	82	26	parenchyma	parenchyma	NNS
cord-007726-bqlf72fe	82	27	[	[	-LRB-
cord-007726-bqlf72fe	82	28	30	30	CD
cord-007726-bqlf72fe	82	29	]	]	-RRB-
cord-007726-bqlf72fe	82	30	.	.	.
cord-007726-bqlf72fe	83	1	Another	another	DT
cord-007726-bqlf72fe	83	2	example	example	NN
cord-007726-bqlf72fe	83	3	is	be	VBZ
cord-007726-bqlf72fe	83	4	anatomy	anatomy	NN
cord-007726-bqlf72fe	83	5	:	:	:
cord-007726-bqlf72fe	83	6	in	in	IN
cord-007726-bqlf72fe	83	7	contrast	contrast	NN
cord-007726-bqlf72fe	83	8	to	to	IN
cord-007726-bqlf72fe	83	9	humans	human	NNS
cord-007726-bqlf72fe	83	10	,	,	,
cord-007726-bqlf72fe	83	11	mice	mouse	NNS
cord-007726-bqlf72fe	83	12	lack	lack	VBP
cord-007726-bqlf72fe	83	13	an	an	DT
cord-007726-bqlf72fe	83	14	extensive	extensive	JJ
cord-007726-bqlf72fe	83	15	pulmonary	pulmonary	JJ
cord-007726-bqlf72fe	83	16	circulation	circulation	NN
cord-007726-bqlf72fe	83	17	,	,	,
cord-007726-bqlf72fe	83	18	which	which	WDT
cord-007726-bqlf72fe	83	19	may	may	MD
cord-007726-bqlf72fe	83	20	have	have	VB
cord-007726-bqlf72fe	83	21	significant	significant	JJ
cord-007726-bqlf72fe	83	22	effects	effect	NNS
cord-007726-bqlf72fe	83	23	on	on	IN
cord-007726-bqlf72fe	83	24	leukocyte	leukocyte	NN
cord-007726-bqlf72fe	83	25	adhesion	adhesion	NN
cord-007726-bqlf72fe	83	26	and	and	CC
cord-007726-bqlf72fe	83	27	migration	migration	NN
cord-007726-bqlf72fe	83	28	,	,	,
cord-007726-bqlf72fe	83	29	and	and	CC
cord-007726-bqlf72fe	83	30	subsequently	subsequently	RB
cord-007726-bqlf72fe	83	31	inflammation	inflammation	NN
cord-007726-bqlf72fe	83	32	[	[	-LRB-
cord-007726-bqlf72fe	83	33	31	31	CD
cord-007726-bqlf72fe	83	34	]	]	-RRB-
cord-007726-bqlf72fe	83	35	.	.	.
cord-007726-bqlf72fe	84	1	Still	still	RB
cord-007726-bqlf72fe	84	2	,	,	,
cord-007726-bqlf72fe	84	3	as	as	RB
cord-007726-bqlf72fe	84	4	long	long	RB
cord-007726-bqlf72fe	84	5	as	as	IN
cord-007726-bqlf72fe	84	6	these	these	DT
cord-007726-bqlf72fe	84	7	differences	difference	NNS
cord-007726-bqlf72fe	84	8	are	be	VBP
cord-007726-bqlf72fe	84	9	taken	take	VBN
cord-007726-bqlf72fe	84	10	into	into	IN
cord-007726-bqlf72fe	84	11	consideration	consideration	NN
cord-007726-bqlf72fe	84	12	,	,	,
cord-007726-bqlf72fe	84	13	mouse	mouse	NN
cord-007726-bqlf72fe	84	14	models	model	NNS
cord-007726-bqlf72fe	84	15	can	can	MD
cord-007726-bqlf72fe	84	16	be	be	VB
cord-007726-bqlf72fe	84	17	powerful	powerful	JJ
cord-007726-bqlf72fe	84	18	tools	tool	NNS
cord-007726-bqlf72fe	84	19	in	in	IN
cord-007726-bqlf72fe	84	20	the	the	DT
cord-007726-bqlf72fe	84	21	discovery	discovery	NN
cord-007726-bqlf72fe	84	22	and	and	CC
cord-007726-bqlf72fe	84	23	exploitation	exploitation	NN
cord-007726-bqlf72fe	84	24	of	of	IN
cord-007726-bqlf72fe	84	25	new	new	JJ
cord-007726-bqlf72fe	84	26	targets	target	NNS
cord-007726-bqlf72fe	84	27	for	for	IN
cord-007726-bqlf72fe	84	28	the	the	DT
cord-007726-bqlf72fe	84	29	treatment	treatment	NN
cord-007726-bqlf72fe	84	30	of	of	IN
cord-007726-bqlf72fe	84	31	human	human	JJ
cord-007726-bqlf72fe	84	32	disease	disease	NN
cord-007726-bqlf72fe	84	33	.	.	.
cord-007726-bqlf72fe	85	1	The	the	DT
cord-007726-bqlf72fe	85	2	World	World	NNP
cord-007726-bqlf72fe	85	3	Health	Health	NNP
cord-007726-bqlf72fe	85	4	Organization	Organization	NNP
cord-007726-bqlf72fe	85	5	(	(	-LRB-
cord-007726-bqlf72fe	85	6	WHO	who	WP
cord-007726-bqlf72fe	85	7	)	)	-RRB-
cord-007726-bqlf72fe	85	8	defines	define	VBZ
cord-007726-bqlf72fe	85	9	asthma	asthma	NN
cord-007726-bqlf72fe	85	10	as	as	IN
cord-007726-bqlf72fe	85	11	a	a	DT
cord-007726-bqlf72fe	85	12	chronic	chronic	JJ
cord-007726-bqlf72fe	85	13	disease	disease	NN
cord-007726-bqlf72fe	85	14	characterized	characterize	VBN
cord-007726-bqlf72fe	85	15	by	by	IN
cord-007726-bqlf72fe	85	16	recurrent	recurrent	JJ
cord-007726-bqlf72fe	85	17	attacks	attack	NNS
cord-007726-bqlf72fe	85	18	of	of	IN
cord-007726-bqlf72fe	85	19	breathlessness	breathlessness	NN
cord-007726-bqlf72fe	85	20	and	and	CC
cord-007726-bqlf72fe	85	21	wheezing	wheezing	NN
cord-007726-bqlf72fe	85	22	,	,	,
cord-007726-bqlf72fe	85	23	which	which	WDT
cord-007726-bqlf72fe	85	24	may	may	MD
cord-007726-bqlf72fe	85	25	vary	vary	VB
cord-007726-bqlf72fe	85	26	in	in	IN
cord-007726-bqlf72fe	85	27	severity	severity	NN
cord-007726-bqlf72fe	85	28	and	and	CC
cord-007726-bqlf72fe	85	29	frequency	frequency	NN
cord-007726-bqlf72fe	85	30	from	from	IN
cord-007726-bqlf72fe	85	31	person	person	NN
cord-007726-bqlf72fe	85	32	to	to	IN
cord-007726-bqlf72fe	85	33	person	person	NN
cord-007726-bqlf72fe	85	34	.	.	.
cord-007726-bqlf72fe	86	1	The	the	DT
cord-007726-bqlf72fe	86	2	disease	disease	NN
cord-007726-bqlf72fe	86	3	is	be	VBZ
cord-007726-bqlf72fe	86	4	characterized	characterize	VBN
cord-007726-bqlf72fe	86	5	by	by	IN
cord-007726-bqlf72fe	86	6	airway	airway	NNP
cord-007726-bqlf72fe	86	7	hyperresponsiveness	hyperresponsiveness	NNP
cord-007726-bqlf72fe	86	8	,	,	,
cord-007726-bqlf72fe	86	9	airway	airway	JJ
cord-007726-bqlf72fe	86	10	smooth	smooth	JJ
cord-007726-bqlf72fe	86	11	muscle	muscle	NN
cord-007726-bqlf72fe	86	12	thickening	thickening	NN
cord-007726-bqlf72fe	86	13	,	,	,
cord-007726-bqlf72fe	86	14	increased	increase	VBN
cord-007726-bqlf72fe	86	15	mucus	mucus	NN
cord-007726-bqlf72fe	86	16	secretion	secretion	NN
cord-007726-bqlf72fe	86	17	and	and	CC
cord-007726-bqlf72fe	86	18	collagen	collagen	NN
cord-007726-bqlf72fe	86	19	deposition	deposition	NN
cord-007726-bqlf72fe	86	20	,	,	,
cord-007726-bqlf72fe	86	21	as	as	RB
cord-007726-bqlf72fe	86	22	well	well	RB
cord-007726-bqlf72fe	86	23	as	as	IN
cord-007726-bqlf72fe	86	24	prominent	prominent	JJ
cord-007726-bqlf72fe	86	25	inflammation	inflammation	NN
cord-007726-bqlf72fe	86	26	affecting	affect	VBG
cord-007726-bqlf72fe	86	27	both	both	CC
cord-007726-bqlf72fe	86	28	large	large	JJ
cord-007726-bqlf72fe	86	29	and	and	CC
cord-007726-bqlf72fe	86	30	small	small	JJ
cord-007726-bqlf72fe	86	31	airways	airway	NNS
cord-007726-bqlf72fe	86	32	[	[	-LRB-
cord-007726-bqlf72fe	86	33	32	32	CD
cord-007726-bqlf72fe	86	34	]	]	-RRB-
cord-007726-bqlf72fe	86	35	.	.	.
cord-007726-bqlf72fe	87	1	Nowadays	nowadays	RB
cord-007726-bqlf72fe	87	2	,	,	,
cord-007726-bqlf72fe	87	3	it	-PRON-	PRP
cord-007726-bqlf72fe	87	4	is	be	VBZ
cord-007726-bqlf72fe	87	5	recognized	recognize	VBN
cord-007726-bqlf72fe	87	6	that	that	IN
cord-007726-bqlf72fe	87	7	asthma	asthma	NN
cord-007726-bqlf72fe	87	8	is	be	VBZ
cord-007726-bqlf72fe	87	9	not	not	RB
cord-007726-bqlf72fe	87	10	a	a	DT
cord-007726-bqlf72fe	87	11	single	single	JJ
cord-007726-bqlf72fe	87	12	homogenous	homogenous	JJ
cord-007726-bqlf72fe	87	13	disease	disease	NN
cord-007726-bqlf72fe	87	14	but	but	CC
cord-007726-bqlf72fe	87	15	rather	rather	RB
cord-007726-bqlf72fe	87	16	several	several	JJ
cord-007726-bqlf72fe	87	17	different	different	JJ
cord-007726-bqlf72fe	87	18	phenotypes	phenotype	NNS
cord-007726-bqlf72fe	87	19	united	unite	VBN
cord-007726-bqlf72fe	87	20	by	by	IN
cord-007726-bqlf72fe	87	21	similar	similar	JJ
cord-007726-bqlf72fe	87	22	clinical	clinical	JJ
cord-007726-bqlf72fe	87	23	symptoms	symptom	NNS
cord-007726-bqlf72fe	87	24	[	[	-LRB-
cord-007726-bqlf72fe	87	25	32	32	CD
cord-007726-bqlf72fe	87	26	,	,	,
cord-007726-bqlf72fe	87	27	33	33	CD
cord-007726-bqlf72fe	87	28	]	]	-RRB-
cord-007726-bqlf72fe	87	29	.	.	.
cord-007726-bqlf72fe	88	1	Only	only	RB
cord-007726-bqlf72fe	88	2	a	a	DT
cord-007726-bqlf72fe	88	3	few	few	JJ
cord-007726-bqlf72fe	88	4	animal	animal	NN
cord-007726-bqlf72fe	88	5	species	specie	NNS
cord-007726-bqlf72fe	88	6	develop	develop	VBP
cord-007726-bqlf72fe	88	7	asthma	asthma	NN
cord-007726-bqlf72fe	88	8	naturally	naturally	RB
cord-007726-bqlf72fe	88	9	,	,	,
cord-007726-bqlf72fe	88	10	including	include	VBG
cord-007726-bqlf72fe	88	11	cats	cat	NNS
cord-007726-bqlf72fe	88	12	and	and	CC
cord-007726-bqlf72fe	88	13	horses	horse	NNS
cord-007726-bqlf72fe	88	14	[	[	-LRB-
cord-007726-bqlf72fe	88	15	34	34	CD
cord-007726-bqlf72fe	88	16	,	,	,
cord-007726-bqlf72fe	88	17	35	35	CD
cord-007726-bqlf72fe	88	18	]	]	-RRB-
cord-007726-bqlf72fe	88	19	,	,	,
cord-007726-bqlf72fe	88	20	whereas	whereas	IN
cord-007726-bqlf72fe	88	21	mice	mouse	NNS
cord-007726-bqlf72fe	88	22	do	do	VBP
cord-007726-bqlf72fe	88	23	not	not	RB
cord-007726-bqlf72fe	88	24	[	[	-LRB-
cord-007726-bqlf72fe	88	25	31	31	CD
cord-007726-bqlf72fe	88	26	]	]	-RRB-
cord-007726-bqlf72fe	88	27	.	.	.
cord-007726-bqlf72fe	89	1	However	however	RB
cord-007726-bqlf72fe	89	2	,	,	,
cord-007726-bqlf72fe	89	3	mice	mouse	NNS
cord-007726-bqlf72fe	89	4	can	can	MD
cord-007726-bqlf72fe	89	5	be	be	VB
cord-007726-bqlf72fe	89	6	manipulated	manipulate	VBN
cord-007726-bqlf72fe	89	7	to	to	TO
cord-007726-bqlf72fe	89	8	develop	develop	VB
cord-007726-bqlf72fe	89	9	a	a	DT
cord-007726-bqlf72fe	89	10	type	type	NN
cord-007726-bqlf72fe	89	11	of	of	IN
cord-007726-bqlf72fe	89	12	allergic	allergic	JJ
cord-007726-bqlf72fe	89	13	airway	airway	NN
cord-007726-bqlf72fe	89	14	inflammation	inflammation	NN
cord-007726-bqlf72fe	89	15	,	,	,
cord-007726-bqlf72fe	89	16	which	which	WDT
cord-007726-bqlf72fe	89	17	is	be	VBZ
cord-007726-bqlf72fe	89	18	similar	similar	JJ
cord-007726-bqlf72fe	89	19	in	in	IN
cord-007726-bqlf72fe	89	20	many	many	JJ
cord-007726-bqlf72fe	89	21	ways	way	NNS
cord-007726-bqlf72fe	89	22	to	to	IN
cord-007726-bqlf72fe	89	23	the	the	DT
cord-007726-bqlf72fe	89	24	human	human	JJ
cord-007726-bqlf72fe	89	25	disease	disease	NN
cord-007726-bqlf72fe	89	26	,	,	,
cord-007726-bqlf72fe	89	27	in	in	IN
cord-007726-bqlf72fe	89	28	response	response	NN
cord-007726-bqlf72fe	89	29	to	to	IN
cord-007726-bqlf72fe	89	30	different	different	JJ
cord-007726-bqlf72fe	89	31	aeroallergens	aeroallergen	NNS
cord-007726-bqlf72fe	89	32	[	[	-LRB-
cord-007726-bqlf72fe	89	33	36	36	CD
cord-007726-bqlf72fe	89	34	]	]	-RRB-
cord-007726-bqlf72fe	89	35	.	.	.
cord-007726-bqlf72fe	90	1	Importantly	importantly	RB
cord-007726-bqlf72fe	90	2	,	,	,
cord-007726-bqlf72fe	90	3	these	these	DT
cord-007726-bqlf72fe	90	4	models	model	NNS
cord-007726-bqlf72fe	90	5	are	be	VBP
cord-007726-bqlf72fe	90	6	capable	capable	JJ
cord-007726-bqlf72fe	90	7	of	of	IN
cord-007726-bqlf72fe	90	8	recapitulating	recapitulate	VBG
cord-007726-bqlf72fe	90	9	only	only	RB
cord-007726-bqlf72fe	90	10	the	the	DT
cord-007726-bqlf72fe	90	11	allergic	allergic	JJ
cord-007726-bqlf72fe	90	12	type	type	NN
cord-007726-bqlf72fe	90	13	of	of	IN
cord-007726-bqlf72fe	90	14	human	human	JJ
cord-007726-bqlf72fe	90	15	asthma	asthma	NN
cord-007726-bqlf72fe	90	16	and	and	CC
cord-007726-bqlf72fe	90	17	have	have	VBP
cord-007726-bqlf72fe	90	18	less	less	JJR
cord-007726-bqlf72fe	90	19	relevance	relevance	NN
cord-007726-bqlf72fe	90	20	for	for	IN
cord-007726-bqlf72fe	90	21	other	other	JJ
cord-007726-bqlf72fe	90	22	types	type	NNS
cord-007726-bqlf72fe	90	23	of	of	IN
cord-007726-bqlf72fe	90	24	asthma	asthma	NN
cord-007726-bqlf72fe	90	25	(	(	-LRB-
cord-007726-bqlf72fe	90	26	i.e.	i.e.	FW
cord-007726-bqlf72fe	90	27	,	,	,
cord-007726-bqlf72fe	90	28	endotypes	endotype	NNS
cord-007726-bqlf72fe	90	29	induced	induce	VBN
cord-007726-bqlf72fe	90	30	by	by	IN
cord-007726-bqlf72fe	90	31	medication	medication	NN
cord-007726-bqlf72fe	90	32	,	,	,
cord-007726-bqlf72fe	90	33	obesity	obesity	NN
cord-007726-bqlf72fe	90	34	,	,	,
cord-007726-bqlf72fe	90	35	and	and	CC
cord-007726-bqlf72fe	90	36	air	air	NN
cord-007726-bqlf72fe	90	37	pollution	pollution	NN
cord-007726-bqlf72fe	90	38	)	)	-RRB-
cord-007726-bqlf72fe	90	39	.	.	.
cord-007726-bqlf72fe	91	1	As	as	IN
cord-007726-bqlf72fe	91	2	with	with	IN
cord-007726-bqlf72fe	91	3	many	many	JJ
cord-007726-bqlf72fe	91	4	human	human	JJ
cord-007726-bqlf72fe	91	5	diseases	disease	NNS
cord-007726-bqlf72fe	91	6	,	,	,
cord-007726-bqlf72fe	91	7	asthma	asthma	NN
cord-007726-bqlf72fe	91	8	has	have	VBZ
cord-007726-bqlf72fe	91	9	a	a	DT
cord-007726-bqlf72fe	91	10	complex	complex	JJ
cord-007726-bqlf72fe	91	11	and	and	CC
cord-007726-bqlf72fe	91	12	multifaceted	multifaceted	JJ
cord-007726-bqlf72fe	91	13	etiology	etiology	NN
cord-007726-bqlf72fe	91	14	,	,	,
cord-007726-bqlf72fe	91	15	where	where	WRB
cord-007726-bqlf72fe	91	16	environmental	environmental	JJ
cord-007726-bqlf72fe	91	17	factors	factor	NNS
cord-007726-bqlf72fe	91	18	,	,	,
cord-007726-bqlf72fe	91	19	genetic	genetic	JJ
cord-007726-bqlf72fe	91	20	susceptibility	susceptibility	NN
cord-007726-bqlf72fe	91	21	,	,	,
cord-007726-bqlf72fe	91	22	and	and	CC
cord-007726-bqlf72fe	91	23	microbial	microbial	JJ
cord-007726-bqlf72fe	91	24	colonization	colonization	NN
cord-007726-bqlf72fe	91	25	all	all	DT
cord-007726-bqlf72fe	91	26	contribute	contribute	VBP
cord-007726-bqlf72fe	91	27	;	;	:
cord-007726-bqlf72fe	91	28	thus	thus	RB
cord-007726-bqlf72fe	91	29	,	,	,
cord-007726-bqlf72fe	91	30	it	-PRON-	PRP
cord-007726-bqlf72fe	91	31	is	be	VBZ
cord-007726-bqlf72fe	91	32	important	important	JJ
cord-007726-bqlf72fe	91	33	to	to	TO
cord-007726-bqlf72fe	91	34	take	take	VB
cord-007726-bqlf72fe	91	35	strain	strain	NN
cord-007726-bqlf72fe	91	36	differences	difference	NNS
cord-007726-bqlf72fe	91	37	into	into	IN
cord-007726-bqlf72fe	91	38	consideration	consideration	NN
cord-007726-bqlf72fe	91	39	.	.	.
cord-007726-bqlf72fe	92	1	Generations	generation	NNS
cord-007726-bqlf72fe	92	2	of	of	IN
cord-007726-bqlf72fe	92	3	inbreeding	inbreeding	NN
cord-007726-bqlf72fe	92	4	have	have	VBP
cord-007726-bqlf72fe	92	5	created	create	VBN
cord-007726-bqlf72fe	92	6	mouse	mouse	NN
cord-007726-bqlf72fe	92	7	strains	strain	NNS
cord-007726-bqlf72fe	92	8	that	that	WDT
cord-007726-bqlf72fe	92	9	differ	differ	VBP
cord-007726-bqlf72fe	92	10	not	not	RB
cord-007726-bqlf72fe	92	11	only	only	RB
cord-007726-bqlf72fe	92	12	in	in	IN
cord-007726-bqlf72fe	92	13	coat	coat	NN
cord-007726-bqlf72fe	92	14	color	color	NN
cord-007726-bqlf72fe	92	15	and	and	CC
cord-007726-bqlf72fe	92	16	disposition	disposition	NN
cord-007726-bqlf72fe	92	17	but	but	CC
cord-007726-bqlf72fe	92	18	also	also	RB
cord-007726-bqlf72fe	92	19	from	from	IN
cord-007726-bqlf72fe	92	20	a	a	DT
cord-007726-bqlf72fe	92	21	physiological	physiological	JJ
cord-007726-bqlf72fe	92	22	,	,	,
cord-007726-bqlf72fe	92	23	immunological	immunological	JJ
cord-007726-bqlf72fe	92	24	,	,	,
cord-007726-bqlf72fe	92	25	and	and	CC
cord-007726-bqlf72fe	92	26	genetic	genetic	JJ
cord-007726-bqlf72fe	92	27	perspective	perspective	NN
cord-007726-bqlf72fe	92	28	.	.	.
cord-007726-bqlf72fe	93	1	Different	different	JJ
cord-007726-bqlf72fe	93	2	strains	strain	NNS
cord-007726-bqlf72fe	93	3	may	may	MD
cord-007726-bqlf72fe	93	4	be	be	VB
cord-007726-bqlf72fe	93	5	more	more	RBR
cord-007726-bqlf72fe	93	6	susceptible	susceptible	JJ
cord-007726-bqlf72fe	93	7	to	to	IN
cord-007726-bqlf72fe	93	8	allergic	allergic	JJ
cord-007726-bqlf72fe	93	9	airway	airway	NN
cord-007726-bqlf72fe	93	10	inflammation	inflammation	NN
cord-007726-bqlf72fe	93	11	or	or	CC
cord-007726-bqlf72fe	93	12	pulmonary	pulmonary	JJ
cord-007726-bqlf72fe	93	13	fibrosis	fibrosis	NN
cord-007726-bqlf72fe	93	14	,	,	,
cord-007726-bqlf72fe	93	15	whereas	whereas	IN
cord-007726-bqlf72fe	93	16	others	other	NNS
cord-007726-bqlf72fe	93	17	are	be	VBP
cord-007726-bqlf72fe	93	18	more	more	RBR
cord-007726-bqlf72fe	93	19	or	or	CC
cord-007726-bqlf72fe	93	20	less	less	RBR
cord-007726-bqlf72fe	93	21	resistant	resistant	JJ
cord-007726-bqlf72fe	93	22	.	.	.
cord-007726-bqlf72fe	94	1	Choosing	choose	VBG
cord-007726-bqlf72fe	94	2	the	the	DT
cord-007726-bqlf72fe	94	3	right	right	JJ
cord-007726-bqlf72fe	94	4	strain	strain	NN
cord-007726-bqlf72fe	94	5	to	to	TO
cord-007726-bqlf72fe	94	6	model	model	VB
cord-007726-bqlf72fe	94	7	a	a	DT
cord-007726-bqlf72fe	94	8	specific	specific	JJ
cord-007726-bqlf72fe	94	9	disease	disease	NN
cord-007726-bqlf72fe	94	10	or	or	CC
cord-007726-bqlf72fe	94	11	pathologic	pathologic	JJ
cord-007726-bqlf72fe	94	12	event	event	NN
cord-007726-bqlf72fe	94	13	is	be	VBZ
cord-007726-bqlf72fe	94	14	thus	thus	RB
cord-007726-bqlf72fe	94	15	essential	essential	JJ
cord-007726-bqlf72fe	94	16	.	.	.
cord-007726-bqlf72fe	95	1	The	the	DT
cord-007726-bqlf72fe	95	2	most	most	RBS
cord-007726-bqlf72fe	95	3	widely	widely	RB
cord-007726-bqlf72fe	95	4	used	use	VBN
cord-007726-bqlf72fe	95	5	strains	strain	NNS
cord-007726-bqlf72fe	95	6	for	for	IN
cord-007726-bqlf72fe	95	7	models	model	NNS
cord-007726-bqlf72fe	95	8	of	of	IN
cord-007726-bqlf72fe	95	9	allergic	allergic	JJ
cord-007726-bqlf72fe	95	10	airway	airway	NN
cord-007726-bqlf72fe	95	11	inflammation	inflammation	NN
cord-007726-bqlf72fe	95	12	are	be	VBP
cord-007726-bqlf72fe	95	13	BALB	BALB	NNP
cord-007726-bqlf72fe	95	14	/	/	SYM
cord-007726-bqlf72fe	95	15	c	c	NN
cord-007726-bqlf72fe	95	16	and	and	CC
cord-007726-bqlf72fe	95	17	C57BL/6	C57BL/6	NNP
cord-007726-bqlf72fe	95	18	.	.	.
cord-007726-bqlf72fe	96	1	These	these	DT
cord-007726-bqlf72fe	96	2	strains	strain	NNS
cord-007726-bqlf72fe	96	3	differ	differ	VBP
cord-007726-bqlf72fe	96	4	regarding	regard	VBG
cord-007726-bqlf72fe	96	5	the	the	DT
cord-007726-bqlf72fe	96	6	type	type	NN
cord-007726-bqlf72fe	96	7	of	of	IN
cord-007726-bqlf72fe	96	8	immune	immune	JJ
cord-007726-bqlf72fe	96	9	response	response	NN
cord-007726-bqlf72fe	96	10	mounted	mount	VBD
cord-007726-bqlf72fe	96	11	to	to	IN
cord-007726-bqlf72fe	96	12	an	an	DT
cord-007726-bqlf72fe	96	13	inhaled	inhale	VBN
cord-007726-bqlf72fe	96	14	allergen	allergen	NN
cord-007726-bqlf72fe	96	15	:	:	:
cord-007726-bqlf72fe	96	16	C57BL/6	C57BL/6	NNP
cord-007726-bqlf72fe	96	17	is	be	VBZ
cord-007726-bqlf72fe	96	18	generally	generally	RB
cord-007726-bqlf72fe	96	19	considered	consider	VBN
cord-007726-bqlf72fe	96	20	a	a	DT
cord-007726-bqlf72fe	96	21	T	t	NN
cord-007726-bqlf72fe	96	22	H	h	NN
cord-007726-bqlf72fe	96	23	1-skewed	1-skewed	CD
cord-007726-bqlf72fe	96	24	strain	strain	NN
cord-007726-bqlf72fe	96	25	,	,	,
cord-007726-bqlf72fe	96	26	whereas	whereas	IN
cord-007726-bqlf72fe	96	27	BALB	BALB	NNP
cord-007726-bqlf72fe	96	28	/	/	SYM
cord-007726-bqlf72fe	96	29	c	c	NNP
cord-007726-bqlf72fe	96	30	is	be	VBZ
cord-007726-bqlf72fe	96	31	regarded	regard	VBN
cord-007726-bqlf72fe	96	32	as	as	IN
cord-007726-bqlf72fe	96	33	a	a	DT
cord-007726-bqlf72fe	96	34	T	t	NN
cord-007726-bqlf72fe	96	35	H	h	NN
cord-007726-bqlf72fe	96	36	2-skewed	2-skewed	CD
cord-007726-bqlf72fe	96	37	strain	strain	NN
cord-007726-bqlf72fe	96	38	[	[	-LRB-
cord-007726-bqlf72fe	96	39	36	36	CD
cord-007726-bqlf72fe	96	40	]	]	-RRB-
cord-007726-bqlf72fe	96	41	.	.	.
cord-007726-bqlf72fe	97	1	Due	due	IN
cord-007726-bqlf72fe	97	2	to	to	IN
cord-007726-bqlf72fe	97	3	their	-PRON-	PRP$
cord-007726-bqlf72fe	97	4	strong	strong	JJ
cord-007726-bqlf72fe	97	5	T	t	NN
cord-007726-bqlf72fe	97	6	H	h	NN
cord-007726-bqlf72fe	97	7	2response	2response	NN
cord-007726-bqlf72fe	97	8	,	,	,
cord-007726-bqlf72fe	97	9	and	and	CC
cord-007726-bqlf72fe	97	10	subsequent	subsequent	JJ
cord-007726-bqlf72fe	97	11	development	development	NN
cord-007726-bqlf72fe	97	12	of	of	IN
cord-007726-bqlf72fe	97	13	robust	robust	JJ
cord-007726-bqlf72fe	97	14	asthmatic	asthmatic	JJ
cord-007726-bqlf72fe	97	15	responses	response	NNS
cord-007726-bqlf72fe	97	16	,	,	,
cord-007726-bqlf72fe	97	17	BALB	BALB	NNP
cord-007726-bqlf72fe	97	18	/	/	SYM
cord-007726-bqlf72fe	97	19	c	c	NNP
cord-007726-bqlf72fe	97	20	has	have	VBZ
cord-007726-bqlf72fe	97	21	been	be	VBN
cord-007726-bqlf72fe	97	22	commonly	commonly	RB
cord-007726-bqlf72fe	97	23	used	use	VBN
cord-007726-bqlf72fe	97	24	to	to	TO
cord-007726-bqlf72fe	97	25	model	model	VB
cord-007726-bqlf72fe	97	26	asthma	asthma	NN
cord-007726-bqlf72fe	97	27	[	[	-LRB-
cord-007726-bqlf72fe	97	28	37	37	CD
cord-007726-bqlf72fe	97	29	]	]	-RRB-
cord-007726-bqlf72fe	97	30	.	.	.
cord-007726-bqlf72fe	98	1	However	however	RB
cord-007726-bqlf72fe	98	2	,	,	,
cord-007726-bqlf72fe	98	3	most	most	JJS
cord-007726-bqlf72fe	98	4	humans	human	NNS
cord-007726-bqlf72fe	98	5	do	do	VBP
cord-007726-bqlf72fe	98	6	not	not	RB
cord-007726-bqlf72fe	98	7	express	express	VB
cord-007726-bqlf72fe	98	8	such	such	PDT
cord-007726-bqlf72fe	98	9	a	a	DT
cord-007726-bqlf72fe	98	10	strongly	strongly	RB
cord-007726-bqlf72fe	98	11	T	T	NNP
cord-007726-bqlf72fe	98	12	H	h	NN
cord-007726-bqlf72fe	98	13	2-skewed	2-skewed	CD
cord-007726-bqlf72fe	98	14	immune	immune	JJ
cord-007726-bqlf72fe	98	15	system	system	NN
cord-007726-bqlf72fe	98	16	,	,	,
cord-007726-bqlf72fe	98	17	suggesting	suggest	VBG
cord-007726-bqlf72fe	98	18	this	this	DT
cord-007726-bqlf72fe	98	19	strain	strain	NN
cord-007726-bqlf72fe	98	20	may	may	MD
cord-007726-bqlf72fe	98	21	not	not	RB
cord-007726-bqlf72fe	98	22	be	be	VB
cord-007726-bqlf72fe	98	23	the	the	DT
cord-007726-bqlf72fe	98	24	best	good	JJS
cord-007726-bqlf72fe	98	25	model	model	NN
cord-007726-bqlf72fe	98	26	of	of	IN
cord-007726-bqlf72fe	98	27	human	human	JJ
cord-007726-bqlf72fe	98	28	disease	disease	NN
cord-007726-bqlf72fe	98	29	;	;	:
cord-007726-bqlf72fe	98	30	instead	instead	RB
cord-007726-bqlf72fe	98	31	,	,	,
cord-007726-bqlf72fe	98	32	C57BL/6	C57BL/6	NNP
cord-007726-bqlf72fe	98	33	may	may	MD
cord-007726-bqlf72fe	98	34	be	be	VB
cord-007726-bqlf72fe	98	35	more	more	RBR
cord-007726-bqlf72fe	98	36	suitable	suitable	JJ
cord-007726-bqlf72fe	98	37	as	as	IN
cord-007726-bqlf72fe	98	38	immune	immune	JJ
cord-007726-bqlf72fe	98	39	responses	response	NNS
cord-007726-bqlf72fe	98	40	in	in	IN
cord-007726-bqlf72fe	98	41	this	this	DT
cord-007726-bqlf72fe	98	42	strain	strain	NN
cord-007726-bqlf72fe	98	43	are	be	VBP
cord-007726-bqlf72fe	98	44	more	more	RBR
cord-007726-bqlf72fe	98	45	similar	similar	JJ
cord-007726-bqlf72fe	98	46	to	to	IN
cord-007726-bqlf72fe	98	47	those	those	DT
cord-007726-bqlf72fe	98	48	of	of	IN
cord-007726-bqlf72fe	98	49	atopic	atopic	JJ
cord-007726-bqlf72fe	98	50	human	human	JJ
cord-007726-bqlf72fe	98	51	subjects	subject	NNS
cord-007726-bqlf72fe	98	52	[	[	-LRB-
cord-007726-bqlf72fe	98	53	37	37	CD
cord-007726-bqlf72fe	98	54	]	]	-RRB-
cord-007726-bqlf72fe	98	55	.	.	.
cord-007726-bqlf72fe	99	1	Furthermore	furthermore	RB
cord-007726-bqlf72fe	99	2	,	,	,
cord-007726-bqlf72fe	99	3	as	as	IN
cord-007726-bqlf72fe	99	4	C57BL/6	C57BL/6	NNP
cord-007726-bqlf72fe	99	5	is	be	VBZ
cord-007726-bqlf72fe	99	6	the	the	DT
cord-007726-bqlf72fe	99	7	most	most	RBS
cord-007726-bqlf72fe	99	8	commonly	commonly	RB
cord-007726-bqlf72fe	99	9	used	use	VBN
cord-007726-bqlf72fe	99	10	strain	strain	NN
cord-007726-bqlf72fe	99	11	for	for	IN
cord-007726-bqlf72fe	99	12	the	the	DT
cord-007726-bqlf72fe	99	13	development	development	NN
cord-007726-bqlf72fe	99	14	of	of	IN
cord-007726-bqlf72fe	99	15	genetically	genetically	RB
cord-007726-bqlf72fe	99	16	manipulated	manipulate	VBN
cord-007726-bqlf72fe	99	17	mice	mouse	NNS
cord-007726-bqlf72fe	99	18	,	,	,
cord-007726-bqlf72fe	99	19	using	use	VBG
cord-007726-bqlf72fe	99	20	these	these	DT
cord-007726-bqlf72fe	99	21	mice	mouse	NNS
cord-007726-bqlf72fe	99	22	allows	allow	VBZ
cord-007726-bqlf72fe	99	23	for	for	IN
cord-007726-bqlf72fe	99	24	very	very	RB
cord-007726-bqlf72fe	99	25	specific	specific	JJ
cord-007726-bqlf72fe	99	26	investigations	investigation	NNS
cord-007726-bqlf72fe	99	27	into	into	IN
cord-007726-bqlf72fe	99	28	disease	disease	NN
cord-007726-bqlf72fe	99	29	pathology	pathology	NN
cord-007726-bqlf72fe	99	30	;	;	:
cord-007726-bqlf72fe	99	31	thus	thus	RB
cord-007726-bqlf72fe	99	32	,	,	,
cord-007726-bqlf72fe	99	33	this	this	DT
cord-007726-bqlf72fe	99	34	strain	strain	NN
cord-007726-bqlf72fe	99	35	is	be	VBZ
cord-007726-bqlf72fe	99	36	increasingly	increasingly	RB
cord-007726-bqlf72fe	99	37	used	use	VBN
cord-007726-bqlf72fe	99	38	in	in	IN
cord-007726-bqlf72fe	99	39	models	model	NNS
cord-007726-bqlf72fe	99	40	of	of	IN
cord-007726-bqlf72fe	99	41	human	human	JJ
cord-007726-bqlf72fe	99	42	lung	lung	NN
cord-007726-bqlf72fe	99	43	disease	disease	NN
cord-007726-bqlf72fe	99	44	.	.	.
cord-007726-bqlf72fe	100	1	Besides	besides	IN
cord-007726-bqlf72fe	100	2	the	the	DT
cord-007726-bqlf72fe	100	3	genetic	genetic	JJ
cord-007726-bqlf72fe	100	4	differences	difference	NNS
cord-007726-bqlf72fe	100	5	in	in	IN
cord-007726-bqlf72fe	100	6	the	the	DT
cord-007726-bqlf72fe	100	7	mouse	mouse	NN
cord-007726-bqlf72fe	100	8	strains	strain	NNS
cord-007726-bqlf72fe	100	9	used	use	VBN
cord-007726-bqlf72fe	100	10	in	in	IN
cord-007726-bqlf72fe	100	11	these	these	DT
cord-007726-bqlf72fe	100	12	models	model	NNS
cord-007726-bqlf72fe	100	13	,	,	,
cord-007726-bqlf72fe	100	14	the	the	DT
cord-007726-bqlf72fe	100	15	etiology	etiology	NN
cord-007726-bqlf72fe	100	16	(	(	-LRB-
cord-007726-bqlf72fe	100	17	the	the	DT
cord-007726-bqlf72fe	100	18	method	method	NN
cord-007726-bqlf72fe	100	19	of	of	IN
cord-007726-bqlf72fe	100	20	disease	disease	NN
cord-007726-bqlf72fe	100	21	induction	induction	NN
cord-007726-bqlf72fe	100	22	)	)	-RRB-
cord-007726-bqlf72fe	100	23	of	of	IN
cord-007726-bqlf72fe	100	24	commonly	commonly	RB
cord-007726-bqlf72fe	100	25	used	use	VBN
cord-007726-bqlf72fe	100	26	models	model	NNS
cord-007726-bqlf72fe	100	27	of	of	IN
cord-007726-bqlf72fe	100	28	asthma	asthma	NN
cord-007726-bqlf72fe	100	29	is	be	VBZ
cord-007726-bqlf72fe	100	30	highly	highly	RB
cord-007726-bqlf72fe	100	31	variable	variable	JJ
cord-007726-bqlf72fe	100	32	.	.	.
cord-007726-bqlf72fe	101	1	In	in	IN
cord-007726-bqlf72fe	101	2	humans	human	NNS
cord-007726-bqlf72fe	101	3	with	with	IN
cord-007726-bqlf72fe	101	4	allergic	allergic	JJ
cord-007726-bqlf72fe	101	5	asthma	asthma	NN
cord-007726-bqlf72fe	101	6	,	,	,
cord-007726-bqlf72fe	101	7	environmental	environmental	JJ
cord-007726-bqlf72fe	101	8	allergen	allergen	NN
cord-007726-bqlf72fe	101	9	exposure	exposure	NN
cord-007726-bqlf72fe	101	10	occurs	occur	VBZ
cord-007726-bqlf72fe	101	11	at	at	IN
cord-007726-bqlf72fe	101	12	the	the	DT
cord-007726-bqlf72fe	101	13	airway	airway	NN
cord-007726-bqlf72fe	101	14	mucosa	mucosa	NN
cord-007726-bqlf72fe	101	15	;	;	:
cord-007726-bqlf72fe	101	16	the	the	DT
cord-007726-bqlf72fe	101	17	immune	immune	JJ
cord-007726-bqlf72fe	101	18	response	response	NN
cord-007726-bqlf72fe	101	19	is	be	VBZ
cord-007726-bqlf72fe	101	20	coordinated	coordinate	VBN
cord-007726-bqlf72fe	101	21	in	in	IN
cord-007726-bqlf72fe	101	22	the	the	DT
cord-007726-bqlf72fe	101	23	bronchopulmonary	bronchopulmonary	JJ
cord-007726-bqlf72fe	101	24	lymph	lymph	NN
cord-007726-bqlf72fe	101	25	nodes	node	NNS
cord-007726-bqlf72fe	101	26	,	,	,
cord-007726-bqlf72fe	101	27	and	and	CC
cord-007726-bqlf72fe	101	28	the	the	DT
cord-007726-bqlf72fe	101	29	T	t	NN
cord-007726-bqlf72fe	101	30	cells	cell	NNS
cord-007726-bqlf72fe	101	31	,	,	,
cord-007726-bqlf72fe	101	32	macrophages	macrophage	NNS
cord-007726-bqlf72fe	101	33	,	,	,
cord-007726-bqlf72fe	101	34	and	and	CC
cord-007726-bqlf72fe	101	35	eosinophils	eosinophil	NNS
cord-007726-bqlf72fe	101	36	recruited	recruit	VBN
cord-007726-bqlf72fe	101	37	as	as	IN
cord-007726-bqlf72fe	101	38	part	part	NN
cord-007726-bqlf72fe	101	39	of	of	IN
cord-007726-bqlf72fe	101	40	this	this	DT
cord-007726-bqlf72fe	101	41	response	response	NN
cord-007726-bqlf72fe	101	42	travel	travel	NN
cord-007726-bqlf72fe	101	43	to	to	IN
cord-007726-bqlf72fe	101	44	the	the	DT
cord-007726-bqlf72fe	101	45	lung	lung	NN
cord-007726-bqlf72fe	101	46	where	where	WRB
cord-007726-bqlf72fe	101	47	they	-PRON-	PRP
cord-007726-bqlf72fe	101	48	mediate	mediate	VBP
cord-007726-bqlf72fe	101	49	the	the	DT
cord-007726-bqlf72fe	101	50	cardinal	cardinal	JJ
cord-007726-bqlf72fe	101	51	features	feature	NNS
cord-007726-bqlf72fe	101	52	of	of	IN
cord-007726-bqlf72fe	101	53	asthma	asthma	NN
cord-007726-bqlf72fe	101	54	:	:	:
cord-007726-bqlf72fe	101	55	airway	airway	NN
cord-007726-bqlf72fe	101	56	inflammation	inflammation	NN
cord-007726-bqlf72fe	101	57	,	,	,
cord-007726-bqlf72fe	101	58	structural	structural	JJ
cord-007726-bqlf72fe	101	59	remodeling	remodeling	NN
cord-007726-bqlf72fe	101	60	of	of	IN
cord-007726-bqlf72fe	101	61	the	the	DT
cord-007726-bqlf72fe	101	62	airway	airway	NN
cord-007726-bqlf72fe	101	63	wall	wall	NN
cord-007726-bqlf72fe	101	64	,	,	,
cord-007726-bqlf72fe	101	65	and	and	CC
cord-007726-bqlf72fe	101	66	airway	airway	NNP
cord-007726-bqlf72fe	101	67	hyperreactivity	hyperreactivity	NNP
cord-007726-bqlf72fe	101	68	[	[	-LRB-
cord-007726-bqlf72fe	101	69	38	38	CD
cord-007726-bqlf72fe	101	70	]	]	-RRB-
cord-007726-bqlf72fe	101	71	.	.	.
cord-007726-bqlf72fe	102	1	Ideally	ideally	RB
cord-007726-bqlf72fe	102	2	,	,	,
cord-007726-bqlf72fe	102	3	these	these	DT
cord-007726-bqlf72fe	102	4	features	feature	NNS
cord-007726-bqlf72fe	102	5	should	should	MD
cord-007726-bqlf72fe	102	6	be	be	VB
cord-007726-bqlf72fe	102	7	found	find	VBN
cord-007726-bqlf72fe	102	8	in	in	IN
cord-007726-bqlf72fe	102	9	a	a	DT
cord-007726-bqlf72fe	102	10	physiologically	physiologically	RB
cord-007726-bqlf72fe	102	11	relevant	relevant	JJ
cord-007726-bqlf72fe	102	12	mouse	mouse	NN
cord-007726-bqlf72fe	102	13	model	model	NN
cord-007726-bqlf72fe	102	14	of	of	IN
cord-007726-bqlf72fe	102	15	asthma	asthma	NN
cord-007726-bqlf72fe	102	16	.	.	.
cord-007726-bqlf72fe	103	1	However	however	RB
cord-007726-bqlf72fe	103	2	,	,	,
cord-007726-bqlf72fe	103	3	for	for	IN
cord-007726-bqlf72fe	103	4	the	the	DT
cord-007726-bqlf72fe	103	5	sake	sake	NN
cord-007726-bqlf72fe	103	6	of	of	IN
cord-007726-bqlf72fe	103	7	cost	cost	NN
cord-007726-bqlf72fe	103	8	and	and	CC
cord-007726-bqlf72fe	103	9	convenience	convenience	NN
cord-007726-bqlf72fe	103	10	,	,	,
cord-007726-bqlf72fe	103	11	early	early	JJ
cord-007726-bqlf72fe	103	12	mouse	mouse	NN
cord-007726-bqlf72fe	103	13	models	model	NNS
cord-007726-bqlf72fe	103	14	of	of	IN
cord-007726-bqlf72fe	103	15	asthma	asthma	NN
cord-007726-bqlf72fe	103	16	used	use	VBD
cord-007726-bqlf72fe	103	17	the	the	DT
cord-007726-bqlf72fe	103	18	surrogate	surrogate	JJ
cord-007726-bqlf72fe	103	19	protein	protein	NN
cord-007726-bqlf72fe	103	20	ovalbumin	ovalbumin	FW
cord-007726-bqlf72fe	103	21	(	(	-LRB-
cord-007726-bqlf72fe	103	22	OVA	OVA	NNP
cord-007726-bqlf72fe	103	23	)	)	-RRB-
cord-007726-bqlf72fe	103	24	[	[	-LRB-
cord-007726-bqlf72fe	103	25	31	31	CD
cord-007726-bqlf72fe	103	26	]	]	-RRB-
cord-007726-bqlf72fe	103	27	rather	rather	RB
cord-007726-bqlf72fe	103	28	than	than	IN
cord-007726-bqlf72fe	103	29	an	an	DT
cord-007726-bqlf72fe	103	30	environmental	environmental	JJ
cord-007726-bqlf72fe	103	31	allergen	allergen	NN
cord-007726-bqlf72fe	103	32	to	to	TO
cord-007726-bqlf72fe	103	33	induce	induce	VB
cord-007726-bqlf72fe	103	34	an	an	DT
cord-007726-bqlf72fe	103	35	immune	immune	JJ
cord-007726-bqlf72fe	103	36	response	response	NN
cord-007726-bqlf72fe	103	37	,	,	,
cord-007726-bqlf72fe	103	38	which	which	WDT
cord-007726-bqlf72fe	103	39	also	also	RB
cord-007726-bqlf72fe	103	40	requires	require	VBZ
cord-007726-bqlf72fe	103	41	the	the	DT
cord-007726-bqlf72fe	103	42	use	use	NN
cord-007726-bqlf72fe	103	43	of	of	IN
cord-007726-bqlf72fe	103	44	a	a	DT
cord-007726-bqlf72fe	103	45	powerful	powerful	JJ
cord-007726-bqlf72fe	103	46	T	t	NN
cord-007726-bqlf72fe	103	47	H	h	NN
cord-007726-bqlf72fe	103	48	2-polarizing	2-polarizing	CD
cord-007726-bqlf72fe	103	49	adjuvant	adjuvant	NN
cord-007726-bqlf72fe	103	50	such	such	JJ
cord-007726-bqlf72fe	103	51	as	as	IN
cord-007726-bqlf72fe	103	52	alum	alum	NN
cord-007726-bqlf72fe	103	53	delivered	deliver	VBD
cord-007726-bqlf72fe	103	54	via	via	IN
cord-007726-bqlf72fe	103	55	the	the	DT
cord-007726-bqlf72fe	103	56	intraperitoneal	intraperitoneal	JJ
cord-007726-bqlf72fe	103	57	route	route	NN
cord-007726-bqlf72fe	103	58	,	,	,
cord-007726-bqlf72fe	103	59	followed	follow	VBN
cord-007726-bqlf72fe	103	60	by	by	IN
cord-007726-bqlf72fe	103	61	OVA	OVA	NNP
cord-007726-bqlf72fe	103	62	nebulization	nebulization	NN
cord-007726-bqlf72fe	103	63	-	-	:
cord-007726-bqlf72fe	103	64	a	a	DT
cord-007726-bqlf72fe	103	65	clear	clear	JJ
cord-007726-bqlf72fe	103	66	divergence	divergence	NN
cord-007726-bqlf72fe	103	67	from	from	IN
cord-007726-bqlf72fe	103	68	the	the	DT
cord-007726-bqlf72fe	103	69	etiology	etiology	NN
cord-007726-bqlf72fe	103	70	of	of	IN
cord-007726-bqlf72fe	103	71	human	human	JJ
cord-007726-bqlf72fe	103	72	asthma	asthma	NN
cord-007726-bqlf72fe	103	73	[	[	-LRB-
cord-007726-bqlf72fe	103	74	36	36	CD
cord-007726-bqlf72fe	103	75	]	]	-RRB-
cord-007726-bqlf72fe	103	76	.	.	.
cord-007726-bqlf72fe	104	1	In	in	IN
cord-007726-bqlf72fe	104	2	terms	term	NNS
cord-007726-bqlf72fe	104	3	of	of	IN
cord-007726-bqlf72fe	104	4	disease	disease	NN
cord-007726-bqlf72fe	104	5	presentation	presentation	NN
cord-007726-bqlf72fe	104	6	,	,	,
cord-007726-bqlf72fe	104	7	mice	mouse	NNS
cord-007726-bqlf72fe	104	8	develop	develop	VBP
cord-007726-bqlf72fe	104	9	some	some	DT
cord-007726-bqlf72fe	104	10	hallmarks	hallmark	NNS
cord-007726-bqlf72fe	104	11	of	of	IN
cord-007726-bqlf72fe	104	12	asthma	asthma	NN
cord-007726-bqlf72fe	104	13	,	,	,
cord-007726-bqlf72fe	104	14	including	include	VBG
cord-007726-bqlf72fe	104	15	airway	airway	JJ
cord-007726-bqlf72fe	104	16	eosinophilic	eosinophilic	JJ
cord-007726-bqlf72fe	104	17	inflammation	inflammation	NN
cord-007726-bqlf72fe	104	18	,	,	,
cord-007726-bqlf72fe	104	19	goblet	goblet	NN
cord-007726-bqlf72fe	104	20	cell	cell	NN
cord-007726-bqlf72fe	104	21	metaplasia	metaplasia	NN
cord-007726-bqlf72fe	104	22	,	,	,
cord-007726-bqlf72fe	104	23	and	and	CC
cord-007726-bqlf72fe	104	24	increased	increase	VBN
cord-007726-bqlf72fe	104	25	airway	airway	NN
cord-007726-bqlf72fe	104	26	smooth	smooth	JJ
cord-007726-bqlf72fe	104	27	muscle	muscle	NN
cord-007726-bqlf72fe	104	28	density	density	NN
cord-007726-bqlf72fe	104	29	[	[	-LRB-
cord-007726-bqlf72fe	104	30	31	31	CD
cord-007726-bqlf72fe	104	31	]	]	-RRB-
cord-007726-bqlf72fe	104	32	.	.	.
cord-007726-bqlf72fe	105	1	After	after	IN
cord-007726-bqlf72fe	105	2	the	the	DT
cord-007726-bqlf72fe	105	3	cessation	cessation	NN
cord-007726-bqlf72fe	105	4	of	of	IN
cord-007726-bqlf72fe	105	5	OVA	OVA	NNP
cord-007726-bqlf72fe	105	6	exposure	exposure	NN
cord-007726-bqlf72fe	105	7	,	,	,
cord-007726-bqlf72fe	105	8	most	most	JJS
cord-007726-bqlf72fe	105	9	of	of	IN
cord-007726-bqlf72fe	105	10	the	the	DT
cord-007726-bqlf72fe	105	11	remodeling	remodeling	NN
cord-007726-bqlf72fe	105	12	resolves	resolve	VBZ
cord-007726-bqlf72fe	105	13	,	,	,
cord-007726-bqlf72fe	105	14	although	although	IN
cord-007726-bqlf72fe	105	15	some	some	DT
cord-007726-bqlf72fe	105	16	structural	structural	JJ
cord-007726-bqlf72fe	105	17	alterations	alteration	NNS
cord-007726-bqlf72fe	105	18	remain	remain	VBP
cord-007726-bqlf72fe	105	19	up	up	RB
cord-007726-bqlf72fe	105	20	to	to	TO
cord-007726-bqlf72fe	105	21	1	1	CD
cord-007726-bqlf72fe	105	22	month	month	NN
cord-007726-bqlf72fe	105	23	after	after	IN
cord-007726-bqlf72fe	105	24	the	the	DT
cord-007726-bqlf72fe	105	25	last	last	JJ
cord-007726-bqlf72fe	105	26	challenge	challenge	NN
cord-007726-bqlf72fe	105	27	[	[	-LRB-
cord-007726-bqlf72fe	105	28	39	39	CD
cord-007726-bqlf72fe	105	29	]	]	-RRB-
cord-007726-bqlf72fe	105	30	.	.	.
cord-007726-bqlf72fe	106	1	Based	base	VBN
cord-007726-bqlf72fe	106	2	on	on	IN
cord-007726-bqlf72fe	106	3	these	these	DT
cord-007726-bqlf72fe	106	4	attributes	attribute	NNS
cord-007726-bqlf72fe	106	5	,	,	,
cord-007726-bqlf72fe	106	6	the	the	DT
cord-007726-bqlf72fe	106	7	OVA	OVA	NNP
cord-007726-bqlf72fe	106	8	model	model	NN
cord-007726-bqlf72fe	106	9	is	be	VBZ
cord-007726-bqlf72fe	106	10	primarily	primarily	RB
cord-007726-bqlf72fe	106	11	a	a	DT
cord-007726-bqlf72fe	106	12	model	model	NN
cord-007726-bqlf72fe	106	13	to	to	TO
cord-007726-bqlf72fe	106	14	investigate	investigate	VB
cord-007726-bqlf72fe	106	15	the	the	DT
cord-007726-bqlf72fe	106	16	initiation	initiation	NN
cord-007726-bqlf72fe	106	17	of	of	IN
cord-007726-bqlf72fe	106	18	inflammation	inflammation	NN
cord-007726-bqlf72fe	106	19	,	,	,
cord-007726-bqlf72fe	106	20	rather	rather	RB
cord-007726-bqlf72fe	106	21	than	than	IN
cord-007726-bqlf72fe	106	22	the	the	DT
cord-007726-bqlf72fe	106	23	chronic	chronic	JJ
cord-007726-bqlf72fe	106	24	progression	progression	NN
cord-007726-bqlf72fe	106	25	and	and	CC
cord-007726-bqlf72fe	106	26	maintenance	maintenance	NN
cord-007726-bqlf72fe	106	27	of	of	IN
cord-007726-bqlf72fe	106	28	inflammation	inflammation	NN
cord-007726-bqlf72fe	106	29	[	[	-LRB-
cord-007726-bqlf72fe	106	30	31	31	CD
cord-007726-bqlf72fe	106	31	]	]	-RRB-
cord-007726-bqlf72fe	106	32	.	.	.
cord-007726-bqlf72fe	107	1	A	a	DT
cord-007726-bqlf72fe	107	2	clear	clear	JJ
cord-007726-bqlf72fe	107	3	advantage	advantage	NN
cord-007726-bqlf72fe	107	4	with	with	IN
cord-007726-bqlf72fe	107	5	the	the	DT
cord-007726-bqlf72fe	107	6	OVA	OVA	NNP
cord-007726-bqlf72fe	107	7	model	model	NN
cord-007726-bqlf72fe	107	8	is	be	VBZ
cord-007726-bqlf72fe	107	9	the	the	DT
cord-007726-bqlf72fe	107	10	number	number	NN
cord-007726-bqlf72fe	107	11	of	of	IN
cord-007726-bqlf72fe	107	12	studies	study	NNS
cord-007726-bqlf72fe	107	13	where	where	WRB
cord-007726-bqlf72fe	107	14	it	-PRON-	PRP
cord-007726-bqlf72fe	107	15	is	be	VBZ
cord-007726-bqlf72fe	107	16	used	use	VBN
cord-007726-bqlf72fe	107	17	;	;	:
cord-007726-bqlf72fe	107	18	both	both	CC
cord-007726-bqlf72fe	107	19	the	the	DT
cord-007726-bqlf72fe	107	20	pros	pro	NNS
cord-007726-bqlf72fe	107	21	and	and	CC
cord-007726-bqlf72fe	107	22	cons	con	NNS
cord-007726-bqlf72fe	107	23	are	be	VBP
cord-007726-bqlf72fe	107	24	familiar	familiar	JJ
cord-007726-bqlf72fe	107	25	.	.	.
cord-007726-bqlf72fe	108	1	It	-PRON-	PRP
cord-007726-bqlf72fe	108	2	is	be	VBZ
cord-007726-bqlf72fe	108	3	easy	easy	JJ
cord-007726-bqlf72fe	108	4	to	to	TO
cord-007726-bqlf72fe	108	5	find	find	VB
cord-007726-bqlf72fe	108	6	a	a	DT
cord-007726-bqlf72fe	108	7	suitable	suitable	JJ
cord-007726-bqlf72fe	108	8	protocol	protocol	NN
cord-007726-bqlf72fe	108	9	,	,	,
cord-007726-bqlf72fe	108	10	and	and	CC
cord-007726-bqlf72fe	108	11	the	the	DT
cord-007726-bqlf72fe	108	12	model	model	NN
cord-007726-bqlf72fe	108	13	is	be	VBZ
cord-007726-bqlf72fe	108	14	readily	readily	RB
cord-007726-bqlf72fe	108	15	accessible	accessible	JJ
cord-007726-bqlf72fe	108	16	and	and	CC
cord-007726-bqlf72fe	108	17	flexible	flexible	JJ
cord-007726-bqlf72fe	108	18	regarding	regard	VBG
cord-007726-bqlf72fe	108	19	the	the	DT
cord-007726-bqlf72fe	108	20	number	number	NN
cord-007726-bqlf72fe	108	21	of	of	IN
cord-007726-bqlf72fe	108	22	sensitizations	sensitization	NNS
cord-007726-bqlf72fe	108	23	and	and	CC
cord-007726-bqlf72fe	108	24	allergen	allergen	NN
cord-007726-bqlf72fe	108	25	doses	dose	NNS
cord-007726-bqlf72fe	108	26	.	.	.
cord-007726-bqlf72fe	109	1	The	the	DT
cord-007726-bqlf72fe	109	2	model	model	NN
cord-007726-bqlf72fe	109	3	is	be	VBZ
cord-007726-bqlf72fe	109	4	relatively	relatively	RB
cord-007726-bqlf72fe	109	5	easy	easy	JJ
cord-007726-bqlf72fe	109	6	to	to	TO
cord-007726-bqlf72fe	109	7	reproduce	reproduce	VB
cord-007726-bqlf72fe	109	8	,	,	,
cord-007726-bqlf72fe	109	9	as	as	IN
cord-007726-bqlf72fe	109	10	OVA	OVA	NNP
cord-007726-bqlf72fe	109	11	and	and	CC
cord-007726-bqlf72fe	109	12	different	different	JJ
cord-007726-bqlf72fe	109	13	adjuvants	adjuvant	NNS
cord-007726-bqlf72fe	109	14	are	be	VBP
cord-007726-bqlf72fe	109	15	easily	easily	RB
cord-007726-bqlf72fe	109	16	obtained	obtain	VBN
cord-007726-bqlf72fe	109	17	.	.	.
cord-007726-bqlf72fe	110	1	However	however	RB
cord-007726-bqlf72fe	110	2	,	,	,
cord-007726-bqlf72fe	110	3	the	the	DT
cord-007726-bqlf72fe	110	4	resolution	resolution	NN
cord-007726-bqlf72fe	110	5	of	of	IN
cord-007726-bqlf72fe	110	6	remodeling	remodeling	NN
cord-007726-bqlf72fe	110	7	following	follow	VBG
cord-007726-bqlf72fe	110	8	the	the	DT
cord-007726-bqlf72fe	110	9	cessation	cessation	NN
cord-007726-bqlf72fe	110	10	of	of	IN
cord-007726-bqlf72fe	110	11	allergen	allergen	NN
cord-007726-bqlf72fe	110	12	provocations	provocation	NNS
cord-007726-bqlf72fe	110	13	is	be	VBZ
cord-007726-bqlf72fe	110	14	a	a	DT
cord-007726-bqlf72fe	110	15	disadvantage	disadvantage	NN
cord-007726-bqlf72fe	110	16	,	,	,
cord-007726-bqlf72fe	110	17	as	as	IN
cord-007726-bqlf72fe	110	18	is	be	VBZ
cord-007726-bqlf72fe	110	19	the	the	DT
cord-007726-bqlf72fe	110	20	practical	practical	JJ
cord-007726-bqlf72fe	110	21	problem	problem	NN
cord-007726-bqlf72fe	110	22	with	with	IN
cord-007726-bqlf72fe	110	23	the	the	DT
cord-007726-bqlf72fe	110	24	nebulization	nebulization	NN
cord-007726-bqlf72fe	110	25	of	of	IN
cord-007726-bqlf72fe	110	26	an	an	DT
cord-007726-bqlf72fe	110	27	allergen	allergen	NN
cord-007726-bqlf72fe	110	28	-	-	:
cord-007726-bqlf72fe	110	29	it	-PRON-	PRP
cord-007726-bqlf72fe	110	30	ends	end	VBZ
cord-007726-bqlf72fe	110	31	up	up	RP
cord-007726-bqlf72fe	110	32	in	in	IN
cord-007726-bqlf72fe	110	33	the	the	DT
cord-007726-bqlf72fe	110	34	mouse	mouse	NN
cord-007726-bqlf72fe	110	35	's	's	POS
cord-007726-bqlf72fe	110	36	coat	coat	NN
cord-007726-bqlf72fe	110	37	and	and	CC
cord-007726-bqlf72fe	110	38	is	be	VBZ
cord-007726-bqlf72fe	110	39	ingested	ingest	VBN
cord-007726-bqlf72fe	110	40	during	during	IN
cord-007726-bqlf72fe	110	41	grooming	grooming	NN
cord-007726-bqlf72fe	110	42	,	,	,
cord-007726-bqlf72fe	110	43	potentially	potentially	RB
cord-007726-bqlf72fe	110	44	resulting	result	VBG
cord-007726-bqlf72fe	110	45	in	in	IN
cord-007726-bqlf72fe	110	46	systemic	systemic	JJ
cord-007726-bqlf72fe	110	47	exposure	exposure	NN
cord-007726-bqlf72fe	110	48	(	(	-LRB-
cord-007726-bqlf72fe	110	49	this	this	DT
cord-007726-bqlf72fe	110	50	is	be	VBZ
cord-007726-bqlf72fe	110	51	particularly	particularly	RB
cord-007726-bqlf72fe	110	52	relevant	relevant	JJ
cord-007726-bqlf72fe	110	53	in	in	IN
cord-007726-bqlf72fe	110	54	models	model	NNS
cord-007726-bqlf72fe	110	55	employing	employ	VBG
cord-007726-bqlf72fe	110	56	systemic	systemic	JJ
cord-007726-bqlf72fe	110	57	,	,	,
cord-007726-bqlf72fe	110	58	intraperitoneal	intraperitoneal	JJ
cord-007726-bqlf72fe	110	59	sensitization	sensitization	NN
cord-007726-bqlf72fe	110	60	)	)	-RRB-
cord-007726-bqlf72fe	110	61	.	.	.
cord-007726-bqlf72fe	111	1	In	in	IN
cord-007726-bqlf72fe	111	2	addition	addition	NN
cord-007726-bqlf72fe	111	3	,	,	,
cord-007726-bqlf72fe	111	4	concerns	concern	NNS
cord-007726-bqlf72fe	111	5	have	have	VBP
cord-007726-bqlf72fe	111	6	been	be	VBN
cord-007726-bqlf72fe	111	7	raised	raise	VBN
cord-007726-bqlf72fe	111	8	against	against	IN
cord-007726-bqlf72fe	111	9	the	the	DT
cord-007726-bqlf72fe	111	10	use	use	NN
cord-007726-bqlf72fe	111	11	of	of	IN
cord-007726-bqlf72fe	111	12	adjuvants	adjuvant	NNS
cord-007726-bqlf72fe	111	13	to	to	TO
cord-007726-bqlf72fe	111	14	induce	induce	VB
cord-007726-bqlf72fe	111	15	the	the	DT
cord-007726-bqlf72fe	111	16	immunological	immunological	JJ
cord-007726-bqlf72fe	111	17	response	response	NN
cord-007726-bqlf72fe	111	18	,	,	,
cord-007726-bqlf72fe	111	19	as	as	RB
cord-007726-bqlf72fe	111	20	well	well	RB
cord-007726-bqlf72fe	111	21	as	as	IN
cord-007726-bqlf72fe	111	22	the	the	DT
cord-007726-bqlf72fe	111	23	clinical	clinical	JJ
cord-007726-bqlf72fe	111	24	relevance	relevance	NN
cord-007726-bqlf72fe	111	25	of	of	IN
cord-007726-bqlf72fe	111	26	OVA	ova	NN
cord-007726-bqlf72fe	111	27	as	as	IN
cord-007726-bqlf72fe	111	28	an	an	DT
cord-007726-bqlf72fe	111	29	allergen	allergen	NN
cord-007726-bqlf72fe	111	30	,	,	,
cord-007726-bqlf72fe	111	31	which	which	WDT
cord-007726-bqlf72fe	111	32	have	have	VBP
cord-007726-bqlf72fe	111	33	driven	drive	VBN
cord-007726-bqlf72fe	111	34	the	the	DT
cord-007726-bqlf72fe	111	35	development	development	NN
cord-007726-bqlf72fe	111	36	of	of	IN
cord-007726-bqlf72fe	111	37	more	more	RBR
cord-007726-bqlf72fe	111	38	clinically	clinically	RB
cord-007726-bqlf72fe	111	39	relevant	relevant	JJ
cord-007726-bqlf72fe	111	40	allergens	allergen	NNS
cord-007726-bqlf72fe	111	41	and	and	CC
cord-007726-bqlf72fe	111	42	models	model	NNS
cord-007726-bqlf72fe	111	43	[	[	-LRB-
cord-007726-bqlf72fe	111	44	31	31	CD
cord-007726-bqlf72fe	111	45	]	]	-RRB-
cord-007726-bqlf72fe	111	46	.	.	.
cord-007726-bqlf72fe	112	1	The	the	DT
cord-007726-bqlf72fe	112	2	common	common	JJ
cord-007726-bqlf72fe	112	3	environmental	environmental	JJ
cord-007726-bqlf72fe	112	4	aeroallergen	aeroallergen	NNP
cord-007726-bqlf72fe	112	5	house	house	NNP
cord-007726-bqlf72fe	112	6	dust	dust	NN
cord-007726-bqlf72fe	112	7	mite	mite	NNP
cord-007726-bqlf72fe	112	8	(	(	-LRB-
cord-007726-bqlf72fe	112	9	HDM	HDM	NNP
cord-007726-bqlf72fe	112	10	)	)	-RRB-
cord-007726-bqlf72fe	112	11	extract	extract	NN
cord-007726-bqlf72fe	112	12	is	be	VBZ
cord-007726-bqlf72fe	112	13	increasingly	increasingly	RB
cord-007726-bqlf72fe	112	14	used	use	VBN
cord-007726-bqlf72fe	112	15	to	to	TO
cord-007726-bqlf72fe	112	16	initiate	initiate	VB
cord-007726-bqlf72fe	112	17	disease	disease	NN
cord-007726-bqlf72fe	112	18	in	in	IN
cord-007726-bqlf72fe	112	19	mouse	mouse	NN
cord-007726-bqlf72fe	112	20	models	model	NNS
cord-007726-bqlf72fe	112	21	of	of	IN
cord-007726-bqlf72fe	112	22	allergic	allergic	JJ
cord-007726-bqlf72fe	112	23	airway	airway	NN
cord-007726-bqlf72fe	112	24	inflammation	inflammation	NN
cord-007726-bqlf72fe	112	25	,	,	,
cord-007726-bqlf72fe	112	26	as	as	IN
cord-007726-bqlf72fe	112	27	it	-PRON-	PRP
cord-007726-bqlf72fe	112	28	is	be	VBZ
cord-007726-bqlf72fe	112	29	a	a	DT
cord-007726-bqlf72fe	112	30	common	common	JJ
cord-007726-bqlf72fe	112	31	human	human	JJ
cord-007726-bqlf72fe	112	32	allergen	allergen	NN
cord-007726-bqlf72fe	112	33	(	(	-LRB-
cord-007726-bqlf72fe	112	34	around	around	IN
cord-007726-bqlf72fe	112	35	50	50	CD
cord-007726-bqlf72fe	112	36	%	%	NN
cord-007726-bqlf72fe	112	37	of	of	IN
cord-007726-bqlf72fe	112	38	asthmatics	asthmatic	NNS
cord-007726-bqlf72fe	112	39	are	be	VBP
cord-007726-bqlf72fe	112	40	sensitized	sensitize	VBN
cord-007726-bqlf72fe	112	41	to	to	IN
cord-007726-bqlf72fe	112	42	HDM	HDM	NNP
cord-007726-bqlf72fe	112	43	[	[	-LRB-
cord-007726-bqlf72fe	112	44	40	40	CD
cord-007726-bqlf72fe	112	45	]	]	-RRB-
cord-007726-bqlf72fe	112	46	)	)	-RRB-
cord-007726-bqlf72fe	112	47	that	that	WDT
cord-007726-bqlf72fe	112	48	evokes	evoke	VBZ
cord-007726-bqlf72fe	112	49	asthma	asthma	NN
cord-007726-bqlf72fe	112	50	attacks	attack	NNS
cord-007726-bqlf72fe	112	51	and	and	CC
cord-007726-bqlf72fe	112	52	other	other	JJ
cord-007726-bqlf72fe	112	53	allergic	allergic	JJ
cord-007726-bqlf72fe	112	54	responses	response	NNS
cord-007726-bqlf72fe	112	55	in	in	IN
cord-007726-bqlf72fe	112	56	susceptible	susceptible	JJ
cord-007726-bqlf72fe	112	57	individuals	individual	NNS
cord-007726-bqlf72fe	112	58	.	.	.
cord-007726-bqlf72fe	113	1	In	in	IN
cord-007726-bqlf72fe	113	2	addition	addition	NN
cord-007726-bqlf72fe	113	3	,	,	,
cord-007726-bqlf72fe	113	4	HDM	HDM	NNP
cord-007726-bqlf72fe	113	5	has	have	VBZ
cord-007726-bqlf72fe	113	6	inherent	inherent	JJ
cord-007726-bqlf72fe	113	7	allergenic	allergenic	JJ
cord-007726-bqlf72fe	113	8	properties	property	NNS
cord-007726-bqlf72fe	113	9	,	,	,
cord-007726-bqlf72fe	113	10	likely	likely	RB
cord-007726-bqlf72fe	113	11	due	due	IN
cord-007726-bqlf72fe	113	12	to	to	IN
cord-007726-bqlf72fe	113	13	components	component	NNS
cord-007726-bqlf72fe	113	14	with	with	IN
cord-007726-bqlf72fe	113	15	protease	protease	NN
cord-007726-bqlf72fe	113	16	activity	activity	NN
cord-007726-bqlf72fe	113	17	[	[	-LRB-
cord-007726-bqlf72fe	113	18	40	40	CD
cord-007726-bqlf72fe	113	19	]	]	-RRB-
cord-007726-bqlf72fe	113	20	,	,	,
cord-007726-bqlf72fe	113	21	so	so	CC
cord-007726-bqlf72fe	113	22	there	there	EX
cord-007726-bqlf72fe	113	23	is	be	VBZ
cord-007726-bqlf72fe	113	24	no	no	DT
cord-007726-bqlf72fe	113	25	need	need	NN
cord-007726-bqlf72fe	113	26	to	to	TO
cord-007726-bqlf72fe	113	27	use	use	VB
cord-007726-bqlf72fe	113	28	an	an	DT
cord-007726-bqlf72fe	113	29	adjuvant	adjuvant	NN
cord-007726-bqlf72fe	113	30	,	,	,
cord-007726-bqlf72fe	113	31	thus	thus	RB
cord-007726-bqlf72fe	113	32	improving	improve	VBG
cord-007726-bqlf72fe	113	33	the	the	DT
cord-007726-bqlf72fe	113	34	etiological	etiological	JJ
cord-007726-bqlf72fe	113	35	similarity	similarity	NN
cord-007726-bqlf72fe	113	36	of	of	IN
cord-007726-bqlf72fe	113	37	these	these	DT
cord-007726-bqlf72fe	113	38	models	model	NNS
cord-007726-bqlf72fe	113	39	with	with	IN
cord-007726-bqlf72fe	113	40	the	the	DT
cord-007726-bqlf72fe	113	41	clinical	clinical	JJ
cord-007726-bqlf72fe	113	42	situation	situation	NN
cord-007726-bqlf72fe	113	43	[	[	-LRB-
cord-007726-bqlf72fe	113	44	41	41	CD
cord-007726-bqlf72fe	113	45	]	]	-RRB-
cord-007726-bqlf72fe	113	46	.	.	.
cord-007726-bqlf72fe	114	1	In	in	IN
cord-007726-bqlf72fe	114	2	contrast	contrast	NN
cord-007726-bqlf72fe	114	3	to	to	IN
cord-007726-bqlf72fe	114	4	OVA	OVA	NNP
cord-007726-bqlf72fe	114	5	,	,	,
cord-007726-bqlf72fe	114	6	prolonged	prolong	VBN
cord-007726-bqlf72fe	114	7	exposure	exposure	NN
cord-007726-bqlf72fe	114	8	of	of	IN
cord-007726-bqlf72fe	114	9	HDM	HDM	NNP
cord-007726-bqlf72fe	114	10	(	(	-LRB-
cord-007726-bqlf72fe	114	11	up	up	IN
cord-007726-bqlf72fe	114	12	to	to	TO
cord-007726-bqlf72fe	114	13	7	7	CD
cord-007726-bqlf72fe	114	14	weeks	week	NNS
cord-007726-bqlf72fe	114	15	)	)	-RRB-
cord-007726-bqlf72fe	114	16	induces	induce	VBZ
cord-007726-bqlf72fe	114	17	asthma	asthma	NN
cord-007726-bqlf72fe	114	18	-	-	HYPH
cord-007726-bqlf72fe	114	19	like	like	JJ
cord-007726-bqlf72fe	114	20	severe	severe	JJ
cord-007726-bqlf72fe	114	21	airway	airway	NN
cord-007726-bqlf72fe	114	22	inflammation	inflammation	NN
cord-007726-bqlf72fe	114	23	with	with	IN
cord-007726-bqlf72fe	114	24	prominent	prominent	JJ
cord-007726-bqlf72fe	114	25	eosinophilia	eosinophilia	NN
cord-007726-bqlf72fe	114	26	,	,	,
cord-007726-bqlf72fe	114	27	severe	severe	JJ
cord-007726-bqlf72fe	114	28	hyperreactivity	hyperreactivity	NN
cord-007726-bqlf72fe	114	29	to	to	IN
cord-007726-bqlf72fe	114	30	methacholine	methacholine	NN
cord-007726-bqlf72fe	114	31	,	,	,
cord-007726-bqlf72fe	114	32	and	and	CC
cord-007726-bqlf72fe	114	33	robust	robust	JJ
cord-007726-bqlf72fe	114	34	remodeling	remodeling	NN
cord-007726-bqlf72fe	114	35	of	of	IN
cord-007726-bqlf72fe	114	36	the	the	DT
cord-007726-bqlf72fe	114	37	airway	airway	NN
cord-007726-bqlf72fe	114	38	wall	wall	NN
cord-007726-bqlf72fe	114	39	[	[	-LRB-
cord-007726-bqlf72fe	114	40	41	41	CD
cord-007726-bqlf72fe	114	41	]	]	-RRB-
cord-007726-bqlf72fe	114	42	,	,	,
cord-007726-bqlf72fe	114	43	i.e.	i.e.	FW
cord-007726-bqlf72fe	114	44	,	,	,
cord-007726-bqlf72fe	114	45	the	the	DT
cord-007726-bqlf72fe	114	46	presentation	presentation	NN
cord-007726-bqlf72fe	114	47	of	of	IN
cord-007726-bqlf72fe	114	48	chronic	chronic	JJ
cord-007726-bqlf72fe	114	49	respiratory	respiratory	JJ
cord-007726-bqlf72fe	114	50	HDM	HDM	NNP
cord-007726-bqlf72fe	114	51	exposure	exposure	NN
cord-007726-bqlf72fe	114	52	in	in	IN
cord-007726-bqlf72fe	114	53	mice	mouse	NNS
cord-007726-bqlf72fe	114	54	effectively	effectively	RB
cord-007726-bqlf72fe	114	55	recapitulates	recapitulate	VBZ
cord-007726-bqlf72fe	114	56	the	the	DT
cord-007726-bqlf72fe	114	57	key	key	JJ
cord-007726-bqlf72fe	114	58	features	feature	NNS
cord-007726-bqlf72fe	114	59	of	of	IN
cord-007726-bqlf72fe	114	60	human	human	JJ
cord-007726-bqlf72fe	114	61	allergic	allergic	JJ
cord-007726-bqlf72fe	114	62	asthma	asthma	NN
cord-007726-bqlf72fe	114	63	.	.	.
cord-007726-bqlf72fe	115	1	Importantly	importantly	RB
cord-007726-bqlf72fe	115	2	,	,	,
cord-007726-bqlf72fe	115	3	the	the	DT
cord-007726-bqlf72fe	115	4	airway	airway	NN
cord-007726-bqlf72fe	115	5	structural	structural	JJ
cord-007726-bqlf72fe	115	6	changes	change	NNS
cord-007726-bqlf72fe	115	7	induced	induce	VBN
cord-007726-bqlf72fe	115	8	by	by	IN
cord-007726-bqlf72fe	115	9	chronic	chronic	JJ
cord-007726-bqlf72fe	115	10	HDM	HDM	NNP
cord-007726-bqlf72fe	115	11	exposure	exposure	NN
cord-007726-bqlf72fe	115	12	,	,	,
cord-007726-bqlf72fe	115	13	such	such	JJ
cord-007726-bqlf72fe	115	14	as	as	IN
cord-007726-bqlf72fe	115	15	increased	increase	VBN
cord-007726-bqlf72fe	115	16	collagen	collagen	NN
cord-007726-bqlf72fe	115	17	deposition	deposition	NN
cord-007726-bqlf72fe	115	18	,	,	,
cord-007726-bqlf72fe	115	19	airway	airway	JJ
cord-007726-bqlf72fe	115	20	smooth	smooth	JJ
cord-007726-bqlf72fe	115	21	muscle	muscle	NN
cord-007726-bqlf72fe	115	22	thickening	thickening	NN
cord-007726-bqlf72fe	115	23	,	,	,
cord-007726-bqlf72fe	115	24	and	and	CC
cord-007726-bqlf72fe	115	25	microvascular	microvascular	JJ
cord-007726-bqlf72fe	115	26	alterations	alteration	NNS
cord-007726-bqlf72fe	115	27	,	,	,
cord-007726-bqlf72fe	115	28	persist	persist	VBP
cord-007726-bqlf72fe	115	29	for	for	IN
cord-007726-bqlf72fe	115	30	at	at	RB
cord-007726-bqlf72fe	115	31	least	least	JJS
cord-007726-bqlf72fe	115	32	4	4	CD
cord-007726-bqlf72fe	115	33	weeks	week	NNS
cord-007726-bqlf72fe	115	34	after	after	IN
cord-007726-bqlf72fe	115	35	the	the	DT
cord-007726-bqlf72fe	115	36	cessation	cessation	NN
cord-007726-bqlf72fe	115	37	of	of	IN
cord-007726-bqlf72fe	115	38	HDM	HDM	NNP
cord-007726-bqlf72fe	115	39	exposure	exposure	NN
cord-007726-bqlf72fe	115	40	[	[	-LRB-
cord-007726-bqlf72fe	115	41	42	42	CD
cord-007726-bqlf72fe	115	42	]	]	-RRB-
cord-007726-bqlf72fe	115	43	,	,	,
cord-007726-bqlf72fe	115	44	another	another	DT
cord-007726-bqlf72fe	115	45	commonality	commonality	NN
cord-007726-bqlf72fe	115	46	with	with	IN
cord-007726-bqlf72fe	115	47	human	human	JJ
cord-007726-bqlf72fe	115	48	asthma	asthma	NN
cord-007726-bqlf72fe	115	49	in	in	IN
cord-007726-bqlf72fe	115	50	which	which	WDT
cord-007726-bqlf72fe	115	51	airway	airway	NN
cord-007726-bqlf72fe	115	52	remodeling	remodeling	NN
cord-007726-bqlf72fe	115	53	is	be	VBZ
cord-007726-bqlf72fe	115	54	currently	currently	RB
cord-007726-bqlf72fe	115	55	considered	consider	VBN
cord-007726-bqlf72fe	115	56	to	to	TO
cord-007726-bqlf72fe	115	57	be	be	VB
cord-007726-bqlf72fe	115	58	irreversible	irreversible	JJ
cord-007726-bqlf72fe	115	59	.	.	.
cord-007726-bqlf72fe	116	1	Thus	thus	RB
cord-007726-bqlf72fe	116	2	,	,	,
cord-007726-bqlf72fe	116	3	the	the	DT
cord-007726-bqlf72fe	116	4	advantages	advantage	NNS
cord-007726-bqlf72fe	116	5	of	of	IN
cord-007726-bqlf72fe	116	6	using	use	VBG
cord-007726-bqlf72fe	116	7	HDM	HDM	NNP
cord-007726-bqlf72fe	116	8	as	as	IN
cord-007726-bqlf72fe	116	9	the	the	DT
cord-007726-bqlf72fe	116	10	allergen	allergen	NN
cord-007726-bqlf72fe	116	11	in	in	IN
cord-007726-bqlf72fe	116	12	mouse	mouse	NN
cord-007726-bqlf72fe	116	13	models	model	NNS
cord-007726-bqlf72fe	116	14	of	of	IN
cord-007726-bqlf72fe	116	15	asthma	asthma	NN
cord-007726-bqlf72fe	116	16	are	be	VBP
cord-007726-bqlf72fe	116	17	the	the	DT
cord-007726-bqlf72fe	116	18	clinical	clinical	JJ
cord-007726-bqlf72fe	116	19	relevance	relevance	NN
cord-007726-bqlf72fe	116	20	of	of	IN
cord-007726-bqlf72fe	116	21	the	the	DT
cord-007726-bqlf72fe	116	22	allergen	allergen	NN
cord-007726-bqlf72fe	116	23	[	[	-LRB-
cord-007726-bqlf72fe	116	24	43	43	CD
cord-007726-bqlf72fe	116	25	]	]	-RRB-
cord-007726-bqlf72fe	116	26	and	and	CC
cord-007726-bqlf72fe	116	27	the	the	DT
cord-007726-bqlf72fe	116	28	route	route	NN
cord-007726-bqlf72fe	116	29	of	of	IN
cord-007726-bqlf72fe	116	30	delivery	delivery	NN
cord-007726-bqlf72fe	116	31	via	via	IN
cord-007726-bqlf72fe	116	32	the	the	DT
cord-007726-bqlf72fe	116	33	respiratory	respiratory	JJ
cord-007726-bqlf72fe	116	34	tract	tract	NN
cord-007726-bqlf72fe	116	35	.	.	.
cord-007726-bqlf72fe	117	1	Moreover	moreover	RB
cord-007726-bqlf72fe	117	2	,	,	,
cord-007726-bqlf72fe	117	3	studies	study	NNS
cord-007726-bqlf72fe	117	4	have	have	VBP
cord-007726-bqlf72fe	117	5	shown	show	VBN
cord-007726-bqlf72fe	117	6	that	that	IN
cord-007726-bqlf72fe	117	7	the	the	DT
cord-007726-bqlf72fe	117	8	type	type	NN
cord-007726-bqlf72fe	117	9	of	of	IN
cord-007726-bqlf72fe	117	10	inflammation	inflammation	NN
cord-007726-bqlf72fe	117	11	and	and	CC
cord-007726-bqlf72fe	117	12	characteristics	characteristic	NNS
cord-007726-bqlf72fe	117	13	of	of	IN
cord-007726-bqlf72fe	117	14	tissue	tissue	NN
cord-007726-bqlf72fe	117	15	remodeling	remodeling	NN
cord-007726-bqlf72fe	117	16	are	be	VBP
cord-007726-bqlf72fe	117	17	relatively	relatively	RB
cord-007726-bqlf72fe	117	18	similar	similar	JJ
cord-007726-bqlf72fe	117	19	to	to	IN
cord-007726-bqlf72fe	117	20	those	those	DT
cord-007726-bqlf72fe	117	21	seen	see	VBN
cord-007726-bqlf72fe	117	22	in	in	IN
cord-007726-bqlf72fe	117	23	human	human	JJ
cord-007726-bqlf72fe	117	24	asthmatics	asthmatic	NNS
cord-007726-bqlf72fe	117	25	[	[	-LRB-
cord-007726-bqlf72fe	117	26	35	35	CD
cord-007726-bqlf72fe	117	27	,	,	,
cord-007726-bqlf72fe	117	28	41	41	CD
cord-007726-bqlf72fe	117	29	,	,	,
cord-007726-bqlf72fe	117	30	43	43	CD
cord-007726-bqlf72fe	117	31	]	]	-RRB-
cord-007726-bqlf72fe	117	32	.	.	.
cord-007726-bqlf72fe	118	1	One	one	CD
cord-007726-bqlf72fe	118	2	disadvantage	disadvantage	NN
cord-007726-bqlf72fe	118	3	is	be	VBZ
cord-007726-bqlf72fe	118	4	the	the	DT
cord-007726-bqlf72fe	118	5	complexity	complexity	NN
cord-007726-bqlf72fe	118	6	of	of	IN
cord-007726-bqlf72fe	118	7	HDM	HDM	NNP
cord-007726-bqlf72fe	118	8	extract	extract	NN
cord-007726-bqlf72fe	118	9	;	;	:
cord-007726-bqlf72fe	118	10	as	as	IN
cord-007726-bqlf72fe	118	11	a	a	DT
cord-007726-bqlf72fe	118	12	consequence	consequence	NN
cord-007726-bqlf72fe	118	13	of	of	IN
cord-007726-bqlf72fe	118	14	this	this	DT
cord-007726-bqlf72fe	118	15	complexity	complexity	NN
cord-007726-bqlf72fe	118	16	,	,	,
cord-007726-bqlf72fe	118	17	variations	variation	NNS
cord-007726-bqlf72fe	118	18	exist	exist	VBP
cord-007726-bqlf72fe	118	19	in	in	IN
cord-007726-bqlf72fe	118	20	some	some	DT
cord-007726-bqlf72fe	118	21	components	component	NNS
cord-007726-bqlf72fe	118	22	between	between	IN
cord-007726-bqlf72fe	118	23	batches	batch	NNS
cord-007726-bqlf72fe	118	24	,	,	,
cord-007726-bqlf72fe	118	25	particularly	particularly	RB
cord-007726-bqlf72fe	118	26	regarding	regard	VBG
cord-007726-bqlf72fe	118	27	the	the	DT
cord-007726-bqlf72fe	118	28	content	content	NN
cord-007726-bqlf72fe	118	29	of	of	IN
cord-007726-bqlf72fe	118	30	lipopolysaccharide	lipopolysaccharide	NN
cord-007726-bqlf72fe	118	31	,	,	,
cord-007726-bqlf72fe	118	32	so	so	RB
cord-007726-bqlf72fe	118	33	reproducibility	reproducibility	NN
cord-007726-bqlf72fe	118	34	in	in	IN
cord-007726-bqlf72fe	118	35	these	these	DT
cord-007726-bqlf72fe	118	36	studies	study	NNS
cord-007726-bqlf72fe	118	37	may	may	MD
cord-007726-bqlf72fe	118	38	be	be	VB
cord-007726-bqlf72fe	118	39	problematic	problematic	JJ
cord-007726-bqlf72fe	118	40	.	.	.
cord-007726-bqlf72fe	119	1	With	with	IN
cord-007726-bqlf72fe	119	2	similarity	similarity	NN
cord-007726-bqlf72fe	119	3	to	to	IN
cord-007726-bqlf72fe	119	4	HDM	HDM	NNP
cord-007726-bqlf72fe	119	5	,	,	,
cord-007726-bqlf72fe	119	6	these	these	DT
cord-007726-bqlf72fe	119	7	models	model	NNS
cord-007726-bqlf72fe	119	8	were	be	VBD
cord-007726-bqlf72fe	119	9	developed	develop	VBN
cord-007726-bqlf72fe	119	10	to	to	TO
cord-007726-bqlf72fe	119	11	be	be	VB
cord-007726-bqlf72fe	119	12	as	as	RB
cord-007726-bqlf72fe	119	13	clinically	clinically	RB
cord-007726-bqlf72fe	119	14	relevant	relevant	JJ
cord-007726-bqlf72fe	119	15	as	as	IN
cord-007726-bqlf72fe	119	16	possible	possible	JJ
cord-007726-bqlf72fe	119	17	,	,	,
cord-007726-bqlf72fe	119	18	as	as	IN
cord-007726-bqlf72fe	119	19	many	many	JJ
cord-007726-bqlf72fe	119	20	patients	patient	NNS
cord-007726-bqlf72fe	119	21	suffer	suffer	VBP
cord-007726-bqlf72fe	119	22	from	from	IN
cord-007726-bqlf72fe	119	23	allergy	allergy	NN
cord-007726-bqlf72fe	119	24	toward	toward	IN
cord-007726-bqlf72fe	119	25	cockroach	cockroach	NN
cord-007726-bqlf72fe	119	26	allergen	allergen	NN
cord-007726-bqlf72fe	119	27	,	,	,
cord-007726-bqlf72fe	119	28	molds	mold	NNS
cord-007726-bqlf72fe	119	29	,	,	,
cord-007726-bqlf72fe	119	30	and	and	CC
cord-007726-bqlf72fe	119	31	other	other	JJ
cord-007726-bqlf72fe	119	32	environmental	environmental	JJ
cord-007726-bqlf72fe	119	33	irritants	irritant	NNS
cord-007726-bqlf72fe	119	34	.	.	.
cord-007726-bqlf72fe	120	1	A	a	DT
cord-007726-bqlf72fe	120	2	common	common	JJ
cord-007726-bqlf72fe	120	3	feature	feature	NN
cord-007726-bqlf72fe	120	4	of	of	IN
cord-007726-bqlf72fe	120	5	these	these	DT
cord-007726-bqlf72fe	120	6	allergens	allergen	NNS
cord-007726-bqlf72fe	120	7	is	be	VBZ
cord-007726-bqlf72fe	120	8	their	-PRON-	PRP$
cord-007726-bqlf72fe	120	9	complex	complex	JJ
cord-007726-bqlf72fe	120	10	nature	nature	NN
cord-007726-bqlf72fe	120	11	,	,	,
cord-007726-bqlf72fe	120	12	as	as	IN
cord-007726-bqlf72fe	120	13	they	-PRON-	PRP
cord-007726-bqlf72fe	120	14	commonly	commonly	RB
cord-007726-bqlf72fe	120	15	consist	consist	VBP
cord-007726-bqlf72fe	120	16	of	of	IN
cord-007726-bqlf72fe	120	17	a	a	DT
cord-007726-bqlf72fe	120	18	mix	mix	NN
cord-007726-bqlf72fe	120	19	of	of	IN
cord-007726-bqlf72fe	120	20	different	different	JJ
cord-007726-bqlf72fe	120	21	allergic	allergic	JJ
cord-007726-bqlf72fe	120	22	epitopes	epitope	NNS
cord-007726-bqlf72fe	120	23	and	and	CC
cord-007726-bqlf72fe	120	24	fragments	fragment	NNS
cord-007726-bqlf72fe	120	25	.	.	.
cord-007726-bqlf72fe	121	1	This	this	DT
cord-007726-bqlf72fe	121	2	complexity	complexity	NN
cord-007726-bqlf72fe	121	3	is	be	VBZ
cord-007726-bqlf72fe	121	4	most	most	RBS
cord-007726-bqlf72fe	121	5	likely	likely	JJ
cord-007726-bqlf72fe	121	6	why	why	WRB
cord-007726-bqlf72fe	121	7	the	the	DT
cord-007726-bqlf72fe	121	8	immunological	immunological	JJ
cord-007726-bqlf72fe	121	9	reaction	reaction	NN
cord-007726-bqlf72fe	121	10	in	in	IN
cord-007726-bqlf72fe	121	11	mice	mice	NN
cord-007726-bqlf72fe	121	12	is	be	VBZ
cord-007726-bqlf72fe	121	13	relatively	relatively	RB
cord-007726-bqlf72fe	121	14	similar	similar	JJ
cord-007726-bqlf72fe	121	15	to	to	IN
cord-007726-bqlf72fe	121	16	that	that	DT
cord-007726-bqlf72fe	121	17	seen	see	VBN
cord-007726-bqlf72fe	121	18	in	in	IN
cord-007726-bqlf72fe	121	19	asthmatics	asthmatic	NNS
cord-007726-bqlf72fe	121	20	[	[	-LRB-
cord-007726-bqlf72fe	121	21	44	44	CD
cord-007726-bqlf72fe	121	22	]	]	-RRB-
cord-007726-bqlf72fe	121	23	.	.	.
cord-007726-bqlf72fe	122	1	Cockroach	cockroach	NN
cord-007726-bqlf72fe	122	2	allergen	allergen	NN
cord-007726-bqlf72fe	122	3	(	(	-LRB-
cord-007726-bqlf72fe	122	4	CRA	CRA	NNP
cord-007726-bqlf72fe	122	5	)	)	-RRB-
cord-007726-bqlf72fe	122	6	is	be	VBZ
cord-007726-bqlf72fe	122	7	a	a	DT
cord-007726-bqlf72fe	122	8	common	common	JJ
cord-007726-bqlf72fe	122	9	allergen	allergen	NN
cord-007726-bqlf72fe	122	10	,	,	,
cord-007726-bqlf72fe	122	11	known	know	VBN
cord-007726-bqlf72fe	122	12	to	to	TO
cord-007726-bqlf72fe	122	13	induce	induce	VB
cord-007726-bqlf72fe	122	14	asthma	asthma	NN
cord-007726-bqlf72fe	122	15	in	in	IN
cord-007726-bqlf72fe	122	16	susceptible	susceptible	JJ
cord-007726-bqlf72fe	122	17	individuals	individual	NNS
cord-007726-bqlf72fe	122	18	;	;	:
cord-007726-bqlf72fe	122	19	thus	thus	RB
cord-007726-bqlf72fe	122	20	,	,	,
cord-007726-bqlf72fe	122	21	it	-PRON-	PRP
cord-007726-bqlf72fe	122	22	shares	share	VBZ
cord-007726-bqlf72fe	122	23	with	with	IN
cord-007726-bqlf72fe	122	24	HDM	HDM	NNP
cord-007726-bqlf72fe	122	25	the	the	DT
cord-007726-bqlf72fe	122	26	advantage	advantage	NN
cord-007726-bqlf72fe	122	27	of	of	IN
cord-007726-bqlf72fe	122	28	being	be	VBG
cord-007726-bqlf72fe	122	29	highly	highly	RB
cord-007726-bqlf72fe	122	30	clinically	clinically	RB
cord-007726-bqlf72fe	122	31	relevant	relevant	JJ
cord-007726-bqlf72fe	122	32	[	[	-LRB-
cord-007726-bqlf72fe	122	33	45	45	CD
cord-007726-bqlf72fe	122	34	]	]	-RRB-
cord-007726-bqlf72fe	122	35	.	.	.
cord-007726-bqlf72fe	123	1	CRA	CRA	NNP
cord-007726-bqlf72fe	123	2	induces	induce	VBZ
cord-007726-bqlf72fe	123	3	peribronchial	peribronchial	JJ
cord-007726-bqlf72fe	123	4	inflammation	inflammation	NN
cord-007726-bqlf72fe	123	5	with	with	IN
cord-007726-bqlf72fe	123	6	significant	significant	JJ
cord-007726-bqlf72fe	123	7	eosinophilic	eosinophilic	JJ
cord-007726-bqlf72fe	123	8	inflammation	inflammation	NN
cord-007726-bqlf72fe	123	9	and	and	CC
cord-007726-bqlf72fe	123	10	transient	transient	JJ
cord-007726-bqlf72fe	123	11	airway	airway	NN
cord-007726-bqlf72fe	123	12	hyperresponsiveness	hyperresponsiveness	NN
cord-007726-bqlf72fe	123	13	,	,	,
cord-007726-bqlf72fe	123	14	both	both	DT
cord-007726-bqlf72fe	123	15	of	of	IN
cord-007726-bqlf72fe	123	16	which	which	WDT
cord-007726-bqlf72fe	123	17	can	can	MD
cord-007726-bqlf72fe	123	18	be	be	VB
cord-007726-bqlf72fe	123	19	increased	increase	VBN
cord-007726-bqlf72fe	123	20	by	by	IN
cord-007726-bqlf72fe	123	21	repeated	repeat	VBN
cord-007726-bqlf72fe	123	22	administrations	administration	NNS
cord-007726-bqlf72fe	123	23	of	of	IN
cord-007726-bqlf72fe	123	24	the	the	DT
cord-007726-bqlf72fe	123	25	allergen	allergen	NN
cord-007726-bqlf72fe	123	26	[	[	-LRB-
cord-007726-bqlf72fe	123	27	45	45	CD
cord-007726-bqlf72fe	123	28	]	]	-RRB-
cord-007726-bqlf72fe	123	29	.	.	.
cord-007726-bqlf72fe	124	1	Colonization	colonization	NN
cord-007726-bqlf72fe	124	2	of	of	IN
cord-007726-bqlf72fe	124	3	the	the	DT
cord-007726-bqlf72fe	124	4	airways	airway	NNS
cord-007726-bqlf72fe	124	5	with	with	IN
cord-007726-bqlf72fe	124	6	Aspergillus	Aspergillus	NNP
cord-007726-bqlf72fe	124	7	fumigatus	fumigatus	NN
cord-007726-bqlf72fe	124	8	is	be	VBZ
cord-007726-bqlf72fe	124	9	the	the	DT
cord-007726-bqlf72fe	124	10	cause	cause	NN
cord-007726-bqlf72fe	124	11	of	of	IN
cord-007726-bqlf72fe	124	12	allergic	allergic	JJ
cord-007726-bqlf72fe	124	13	bronchopulmonary	bronchopulmonary	JJ
cord-007726-bqlf72fe	124	14	aspergillosis	aspergillosis	NNP
cord-007726-bqlf72fe	124	15	(	(	-LRB-
cord-007726-bqlf72fe	124	16	ABPA	ABPA	NNP
cord-007726-bqlf72fe	124	17	)	)	-RRB-
cord-007726-bqlf72fe	124	18	,	,	,
cord-007726-bqlf72fe	124	19	a	a	DT
cord-007726-bqlf72fe	124	20	disease	disease	NN
cord-007726-bqlf72fe	124	21	where	where	WRB
cord-007726-bqlf72fe	124	22	the	the	DT
cord-007726-bqlf72fe	124	23	lungs	lung	NNS
cord-007726-bqlf72fe	124	24	are	be	VBP
cord-007726-bqlf72fe	124	25	colonized	colonize	VBN
cord-007726-bqlf72fe	124	26	by	by	IN
cord-007726-bqlf72fe	124	27	the	the	DT
cord-007726-bqlf72fe	124	28	fungus	fungus	NN
cord-007726-bqlf72fe	124	29	,	,	,
cord-007726-bqlf72fe	124	30	but	but	CC
cord-007726-bqlf72fe	124	31	allergens	allergen	NNS
cord-007726-bqlf72fe	124	32	from	from	IN
cord-007726-bqlf72fe	124	33	Aspergillus	aspergillus	NN
cord-007726-bqlf72fe	124	34	fumigatus	fumigatus	NN
cord-007726-bqlf72fe	124	35	can	can	MD
cord-007726-bqlf72fe	124	36	also	also	RB
cord-007726-bqlf72fe	124	37	induce	induce	VB
cord-007726-bqlf72fe	124	38	asthma	asthma	NN
cord-007726-bqlf72fe	124	39	similar	similar	JJ
cord-007726-bqlf72fe	124	40	to	to	IN
cord-007726-bqlf72fe	124	41	other	other	JJ
cord-007726-bqlf72fe	124	42	allergens	allergen	NNS
cord-007726-bqlf72fe	124	43	[	[	-LRB-
cord-007726-bqlf72fe	124	44	46	46	CD
cord-007726-bqlf72fe	124	45	]	]	-RRB-
cord-007726-bqlf72fe	124	46	.	.	.
cord-007726-bqlf72fe	125	1	The	the	DT
cord-007726-bqlf72fe	125	2	reaction	reaction	NN
cord-007726-bqlf72fe	125	3	to	to	IN
cord-007726-bqlf72fe	125	4	Aspergillus	aspergillus	NN
cord-007726-bqlf72fe	125	5	allergens	allergen	NNS
cord-007726-bqlf72fe	125	6	is	be	VBZ
cord-007726-bqlf72fe	125	7	robust	robust	JJ
cord-007726-bqlf72fe	125	8	,	,	,
cord-007726-bqlf72fe	125	9	and	and	CC
cord-007726-bqlf72fe	125	10	often	often	RB
cord-007726-bqlf72fe	125	11	no	no	DT
cord-007726-bqlf72fe	125	12	adjuvants	adjuvant	NNS
cord-007726-bqlf72fe	125	13	are	be	VBP
cord-007726-bqlf72fe	125	14	needed	need	VBN
cord-007726-bqlf72fe	125	15	to	to	TO
cord-007726-bqlf72fe	125	16	elicit	elicit	VB
cord-007726-bqlf72fe	125	17	inflammation	inflammation	NN
cord-007726-bqlf72fe	125	18	[	[	-LRB-
cord-007726-bqlf72fe	125	19	46	46	CD
cord-007726-bqlf72fe	125	20	]	]	-RRB-
cord-007726-bqlf72fe	125	21	.	.	.
cord-007726-bqlf72fe	126	1	In	in	IN
cord-007726-bqlf72fe	126	2	addition	addition	NN
cord-007726-bqlf72fe	126	3	to	to	IN
cord-007726-bqlf72fe	126	4	Aspergillus	aspergillus	NN
cord-007726-bqlf72fe	126	5	,	,	,
cord-007726-bqlf72fe	126	6	other	other	JJ
cord-007726-bqlf72fe	126	7	fungi	fungus	NNS
cord-007726-bqlf72fe	126	8	such	such	JJ
cord-007726-bqlf72fe	126	9	as	as	IN
cord-007726-bqlf72fe	126	10	Penicillium	Penicillium	NNP
cord-007726-bqlf72fe	126	11	and	and	CC
cord-007726-bqlf72fe	126	12	Alternaria	Alternaria	NNP
cord-007726-bqlf72fe	126	13	can	can	MD
cord-007726-bqlf72fe	126	14	also	also	RB
cord-007726-bqlf72fe	126	15	induce	induce	VB
cord-007726-bqlf72fe	126	16	asthma	asthma	NN
cord-007726-bqlf72fe	126	17	in	in	IN
cord-007726-bqlf72fe	126	18	humans	human	NNS
cord-007726-bqlf72fe	126	19	and	and	CC
cord-007726-bqlf72fe	126	20	have	have	VBP
cord-007726-bqlf72fe	126	21	been	be	VBN
cord-007726-bqlf72fe	126	22	used	use	VBN
cord-007726-bqlf72fe	126	23	to	to	TO
cord-007726-bqlf72fe	126	24	model	model	VB
cord-007726-bqlf72fe	126	25	disease	disease	NN
cord-007726-bqlf72fe	126	26	in	in	IN
cord-007726-bqlf72fe	126	27	mice	mouse	NNS
cord-007726-bqlf72fe	126	28	[	[	-LRB-
cord-007726-bqlf72fe	126	29	47	47	CD
cord-007726-bqlf72fe	126	30	]	]	-RRB-
cord-007726-bqlf72fe	126	31	.	.	.
cord-007726-bqlf72fe	127	1	A	a	DT
cord-007726-bqlf72fe	127	2	common	common	JJ
cord-007726-bqlf72fe	127	3	difficulty	difficulty	NN
cord-007726-bqlf72fe	127	4	with	with	IN
cord-007726-bqlf72fe	127	5	these	these	DT
cord-007726-bqlf72fe	127	6	allergens	allergen	NNS
cord-007726-bqlf72fe	127	7	is	be	VBZ
cord-007726-bqlf72fe	127	8	the	the	DT
cord-007726-bqlf72fe	127	9	method	method	NN
cord-007726-bqlf72fe	127	10	of	of	IN
cord-007726-bqlf72fe	127	11	administration	administration	NN
cord-007726-bqlf72fe	127	12	,	,	,
cord-007726-bqlf72fe	127	13	as	as	IN
cord-007726-bqlf72fe	127	14	the	the	DT
cord-007726-bqlf72fe	127	15	physiological	physiological	JJ
cord-007726-bqlf72fe	127	16	route	route	NN
cord-007726-bqlf72fe	127	17	is	be	VBZ
cord-007726-bqlf72fe	127	18	believed	believe	VBN
cord-007726-bqlf72fe	127	19	to	to	TO
cord-007726-bqlf72fe	127	20	be	be	VB
cord-007726-bqlf72fe	127	21	the	the	DT
cord-007726-bqlf72fe	127	22	inhalation	inhalation	NN
cord-007726-bqlf72fe	127	23	of	of	IN
cord-007726-bqlf72fe	127	24	dry	dry	JJ
cord-007726-bqlf72fe	127	25	allergens	allergen	NNS
cord-007726-bqlf72fe	127	26	;	;	:
cord-007726-bqlf72fe	127	27	mimicking	mimic	VBG
cord-007726-bqlf72fe	127	28	this	this	DT
cord-007726-bqlf72fe	127	29	route	route	NN
cord-007726-bqlf72fe	127	30	with	with	IN
cord-007726-bqlf72fe	127	31	a	a	DT
cord-007726-bqlf72fe	127	32	nebulizer	nebulizer	NN
cord-007726-bqlf72fe	127	33	introduces	introduce	VBZ
cord-007726-bqlf72fe	127	34	the	the	DT
cord-007726-bqlf72fe	127	35	risk	risk	NN
cord-007726-bqlf72fe	127	36	of	of	IN
cord-007726-bqlf72fe	127	37	the	the	DT
cord-007726-bqlf72fe	127	38	animals	animal	NNS
cord-007726-bqlf72fe	127	39	ingesting	ingest	VBG
cord-007726-bqlf72fe	127	40	the	the	DT
cord-007726-bqlf72fe	127	41	allergen	allergen	NN
cord-007726-bqlf72fe	127	42	and	and	CC
cord-007726-bqlf72fe	127	43	thus	thus	RB
cord-007726-bqlf72fe	127	44	causing	cause	VBG
cord-007726-bqlf72fe	127	45	systemic	systemic	JJ
cord-007726-bqlf72fe	127	46	responses	response	NNS
cord-007726-bqlf72fe	127	47	[	[	-LRB-
cord-007726-bqlf72fe	127	48	47	47	CD
cord-007726-bqlf72fe	127	49	]	]	-RRB-
cord-007726-bqlf72fe	127	50	.	.	.
cord-007726-bqlf72fe	128	1	Exacerbations	exacerbation	NNS
cord-007726-bqlf72fe	128	2	of	of	IN
cord-007726-bqlf72fe	128	3	asthma	asthma	NNS
cord-007726-bqlf72fe	128	4	are	be	VBP
cord-007726-bqlf72fe	128	5	defined	define	VBN
cord-007726-bqlf72fe	128	6	as	as	IN
cord-007726-bqlf72fe	128	7	the	the	DT
cord-007726-bqlf72fe	128	8	worsening	worsening	NN
cord-007726-bqlf72fe	128	9	of	of	IN
cord-007726-bqlf72fe	128	10	symptoms	symptom	NNS
cord-007726-bqlf72fe	128	11	,	,	,
cord-007726-bqlf72fe	128	12	prompting	prompt	VBG
cord-007726-bqlf72fe	128	13	an	an	DT
cord-007726-bqlf72fe	128	14	adjustment	adjustment	NN
cord-007726-bqlf72fe	128	15	in	in	IN
cord-007726-bqlf72fe	128	16	treatment	treatment	NN
cord-007726-bqlf72fe	128	17	,	,	,
cord-007726-bqlf72fe	128	18	and	and	CC
cord-007726-bqlf72fe	128	19	are	be	VBP
cord-007726-bqlf72fe	128	20	believed	believe	VBN
cord-007726-bqlf72fe	128	21	to	to	TO
cord-007726-bqlf72fe	128	22	be	be	VB
cord-007726-bqlf72fe	128	23	associated	associate	VBN
cord-007726-bqlf72fe	128	24	with	with	IN
cord-007726-bqlf72fe	128	25	increased	increase	VBN
cord-007726-bqlf72fe	128	26	inflammation	inflammation	NN
cord-007726-bqlf72fe	128	27	in	in	IN
cord-007726-bqlf72fe	128	28	the	the	DT
cord-007726-bqlf72fe	128	29	distal	distal	JJ
cord-007726-bqlf72fe	128	30	airways	airway	NNS
cord-007726-bqlf72fe	128	31	.	.	.
cord-007726-bqlf72fe	129	1	Clinically	clinically	RB
cord-007726-bqlf72fe	129	2	,	,	,
cord-007726-bqlf72fe	129	3	exacerbations	exacerbation	NNS
cord-007726-bqlf72fe	129	4	are	be	VBP
cord-007726-bqlf72fe	129	5	believed	believe	VBN
cord-007726-bqlf72fe	129	6	to	to	TO
cord-007726-bqlf72fe	129	7	be	be	VB
cord-007726-bqlf72fe	129	8	induced	induce	VBN
cord-007726-bqlf72fe	129	9	by	by	IN
cord-007726-bqlf72fe	129	10	infections	infection	NNS
cord-007726-bqlf72fe	129	11	(	(	-LRB-
cord-007726-bqlf72fe	129	12	most	most	RBS
cord-007726-bqlf72fe	129	13	common	common	JJ
cord-007726-bqlf72fe	129	14	)	)	-RRB-
cord-007726-bqlf72fe	129	15	,	,	,
cord-007726-bqlf72fe	129	16	allergen	allergen	NN
cord-007726-bqlf72fe	129	17	exposure	exposure	NN
cord-007726-bqlf72fe	129	18	,	,	,
cord-007726-bqlf72fe	129	19	or	or	CC
cord-007726-bqlf72fe	129	20	pollutants	pollutant	NNS
cord-007726-bqlf72fe	129	21	,	,	,
cord-007726-bqlf72fe	129	22	which	which	WDT
cord-007726-bqlf72fe	129	23	can	can	MD
cord-007726-bqlf72fe	129	24	be	be	VB
cord-007726-bqlf72fe	129	25	modeled	model	VBN
cord-007726-bqlf72fe	129	26	in	in	IN
cord-007726-bqlf72fe	129	27	different	different	JJ
cord-007726-bqlf72fe	129	28	ways	way	NNS
cord-007726-bqlf72fe	129	29	[	[	-LRB-
cord-007726-bqlf72fe	129	30	48	48	CD
cord-007726-bqlf72fe	129	31	,	,	,
cord-007726-bqlf72fe	129	32	49	49	CD
cord-007726-bqlf72fe	129	33	]	]	-RRB-
cord-007726-bqlf72fe	129	34	:	:	:
cord-007726-bqlf72fe	130	1	1	1	LS
cord-007726-bqlf72fe	130	2	.	.	.
cord-007726-bqlf72fe	131	1	Infections	infection	NNS
cord-007726-bqlf72fe	131	2	with	with	IN
cord-007726-bqlf72fe	131	3	viruses	virus	NNS
cord-007726-bqlf72fe	131	4	and	and	CC
cord-007726-bqlf72fe	131	5	bacteria	bacteria	NNS
cord-007726-bqlf72fe	131	6	or	or	CC
cord-007726-bqlf72fe	131	7	exposure	exposure	NN
cord-007726-bqlf72fe	131	8	to	to	IN
cord-007726-bqlf72fe	131	9	proteins/	proteins/	CD
cord-007726-bqlf72fe	131	10	DNA	DNA	NNP
cord-007726-bqlf72fe	131	11	/	/	SYM
cord-007726-bqlf72fe	131	12	RNA	RNA	NNP
cord-007726-bqlf72fe	131	13	derived	derive	VBN
cord-007726-bqlf72fe	131	14	from	from	IN
cord-007726-bqlf72fe	131	15	these	these	DT
cord-007726-bqlf72fe	131	16	microbes	microbe	NNS
cord-007726-bqlf72fe	131	17	.	.	.
cord-007726-bqlf72fe	132	1	2	2	LS
cord-007726-bqlf72fe	132	2	.	.	.
cord-007726-bqlf72fe	133	1	Administration	administration	NN
cord-007726-bqlf72fe	133	2	of	of	IN
cord-007726-bqlf72fe	133	3	a	a	DT
cord-007726-bqlf72fe	133	4	high	high	JJ
cord-007726-bqlf72fe	133	5	dose	dose	NN
cord-007726-bqlf72fe	133	6	of	of	IN
cord-007726-bqlf72fe	133	7	allergen	allergen	NN
cord-007726-bqlf72fe	133	8	in	in	IN
cord-007726-bqlf72fe	133	9	a	a	DT
cord-007726-bqlf72fe	133	10	previously	previously	RB
cord-007726-bqlf72fe	133	11	sensitized	sensitize	VBN
cord-007726-bqlf72fe	133	12	animal	animal	NN
cord-007726-bqlf72fe	133	13	.	.	.
cord-007726-bqlf72fe	134	1	3	3	LS
cord-007726-bqlf72fe	134	2	.	.	.
cord-007726-bqlf72fe	135	1	Exposure	exposure	NN
cord-007726-bqlf72fe	135	2	to	to	IN
cord-007726-bqlf72fe	135	3	environmental	environmental	JJ
cord-007726-bqlf72fe	135	4	pollutants	pollutant	NNS
cord-007726-bqlf72fe	135	5	,	,	,
cord-007726-bqlf72fe	135	6	such	such	JJ
cord-007726-bqlf72fe	135	7	as	as	IN
cord-007726-bqlf72fe	135	8	diesel	diesel	NN
cord-007726-bqlf72fe	135	9	exhaust	exhaust	NN
cord-007726-bqlf72fe	135	10	or	or	CC
cord-007726-bqlf72fe	135	11	ozone	ozone	NN
cord-007726-bqlf72fe	135	12	.	.	.
cord-007726-bqlf72fe	136	1	Modeling	model	VBG
cord-007726-bqlf72fe	136	2	exacerbations	exacerbation	NNS
cord-007726-bqlf72fe	136	3	adds	add	VBZ
cord-007726-bqlf72fe	136	4	a	a	DT
cord-007726-bqlf72fe	136	5	layer	layer	NN
cord-007726-bqlf72fe	136	6	of	of	IN
cord-007726-bqlf72fe	136	7	complexity	complexity	NN
cord-007726-bqlf72fe	136	8	,	,	,
cord-007726-bqlf72fe	136	9	as	as	IN
cord-007726-bqlf72fe	136	10	robust	robust	JJ
cord-007726-bqlf72fe	136	11	ongoing	ongoing	JJ
cord-007726-bqlf72fe	136	12	allergic	allergic	JJ
cord-007726-bqlf72fe	136	13	airway	airway	NN
cord-007726-bqlf72fe	136	14	inflammation	inflammation	NN
cord-007726-bqlf72fe	136	15	needs	need	VBZ
cord-007726-bqlf72fe	136	16	to	to	TO
cord-007726-bqlf72fe	136	17	be	be	VB
cord-007726-bqlf72fe	136	18	established	establish	VBN
cord-007726-bqlf72fe	136	19	first	first	RB
cord-007726-bqlf72fe	136	20	,	,	,
cord-007726-bqlf72fe	136	21	before	before	IN
cord-007726-bqlf72fe	136	22	challenge	challenge	NN
cord-007726-bqlf72fe	136	23	with	with	IN
cord-007726-bqlf72fe	136	24	the	the	DT
cord-007726-bqlf72fe	136	25	exacerbating	exacerbate	VBG
cord-007726-bqlf72fe	136	26	agent	agent	NN
cord-007726-bqlf72fe	136	27	.	.	.
cord-007726-bqlf72fe	137	1	Both	both	DT
cord-007726-bqlf72fe	137	2	the	the	DT
cord-007726-bqlf72fe	137	3	OVA	OVA	NNP
cord-007726-bqlf72fe	137	4	and	and	CC
cord-007726-bqlf72fe	137	5	HDM	HDM	NNP
cord-007726-bqlf72fe	137	6	models	model	NNS
cord-007726-bqlf72fe	137	7	are	be	VBP
cord-007726-bqlf72fe	137	8	used	use	VBN
cord-007726-bqlf72fe	137	9	in	in	IN
cord-007726-bqlf72fe	137	10	this	this	DT
cord-007726-bqlf72fe	137	11	respect	respect	NN
cord-007726-bqlf72fe	137	12	,	,	,
cord-007726-bqlf72fe	137	13	and	and	CC
cord-007726-bqlf72fe	137	14	in	in	IN
cord-007726-bqlf72fe	137	15	both	both	DT
cord-007726-bqlf72fe	137	16	cases	case	NNS
cord-007726-bqlf72fe	137	17	chronic	chronic	JJ
cord-007726-bqlf72fe	137	18	protocols	protocol	NNS
cord-007726-bqlf72fe	137	19	extending	extend	VBG
cord-007726-bqlf72fe	137	20	for	for	IN
cord-007726-bqlf72fe	137	21	several	several	JJ
cord-007726-bqlf72fe	137	22	weeks	week	NNS
cord-007726-bqlf72fe	137	23	before	before	IN
cord-007726-bqlf72fe	137	24	triggering	trigger	VBG
cord-007726-bqlf72fe	137	25	an	an	DT
cord-007726-bqlf72fe	137	26	exacerbation	exacerbation	NN
cord-007726-bqlf72fe	137	27	have	have	VBP
cord-007726-bqlf72fe	137	28	been	be	VBN
cord-007726-bqlf72fe	137	29	used	use	VBN
cord-007726-bqlf72fe	137	30	[	[	-LRB-
cord-007726-bqlf72fe	137	31	48	48	CD
cord-007726-bqlf72fe	137	32	]	]	-RRB-
cord-007726-bqlf72fe	137	33	.	.	.
cord-007726-bqlf72fe	138	1	Chronic	chronic	JJ
cord-007726-bqlf72fe	138	2	obstructive	obstructive	JJ
cord-007726-bqlf72fe	138	3	pulmonary	pulmonary	JJ
cord-007726-bqlf72fe	138	4	disease	disease	NN
cord-007726-bqlf72fe	138	5	(	(	-LRB-
cord-007726-bqlf72fe	138	6	COPD	COPD	NNP
cord-007726-bqlf72fe	138	7	)	)	-RRB-
cord-007726-bqlf72fe	138	8	is	be	VBZ
cord-007726-bqlf72fe	138	9	characterized	characterize	VBN
cord-007726-bqlf72fe	138	10	by	by	IN
cord-007726-bqlf72fe	138	11	chronic	chronic	JJ
cord-007726-bqlf72fe	138	12	airway	airway	NN
cord-007726-bqlf72fe	138	13	obstruction	obstruction	NN
cord-007726-bqlf72fe	138	14	,	,	,
cord-007726-bqlf72fe	138	15	in	in	IN
cord-007726-bqlf72fe	138	16	contrast	contrast	NN
cord-007726-bqlf72fe	138	17	to	to	IN
cord-007726-bqlf72fe	138	18	asthma	asthma	NN
cord-007726-bqlf72fe	138	19	where	where	WRB
cord-007726-bqlf72fe	138	20	the	the	DT
cord-007726-bqlf72fe	138	21	obstruction	obstruction	NN
cord-007726-bqlf72fe	138	22	is	be	VBZ
cord-007726-bqlf72fe	138	23	reversible	reversible	JJ
cord-007726-bqlf72fe	138	24	(	(	-LRB-
cord-007726-bqlf72fe	138	25	particularly	particularly	RB
cord-007726-bqlf72fe	138	26	in	in	IN
cord-007726-bqlf72fe	138	27	response	response	NN
cord-007726-bqlf72fe	138	28	to	to	IN
cord-007726-bqlf72fe	138	29	bronchodilator	bronchodilator	NN
cord-007726-bqlf72fe	138	30	treatment	treatment	NN
cord-007726-bqlf72fe	138	31	)	)	-RRB-
cord-007726-bqlf72fe	138	32	.	.	.
cord-007726-bqlf72fe	139	1	Clinically	clinically	RB
cord-007726-bqlf72fe	139	2	,	,	,
cord-007726-bqlf72fe	139	3	in	in	IN
cord-007726-bqlf72fe	139	4	COPD	COPD	NNP
cord-007726-bqlf72fe	139	5	,	,	,
cord-007726-bqlf72fe	139	6	chronic	chronic	JJ
cord-007726-bqlf72fe	139	7	bronchitis	bronchitis	NN
cord-007726-bqlf72fe	139	8	and	and	CC
cord-007726-bqlf72fe	139	9	emphysema	emphysema	NN
cord-007726-bqlf72fe	139	10	can	can	MD
cord-007726-bqlf72fe	139	11	occur	occur	VB
cord-007726-bqlf72fe	139	12	either	either	CC
cord-007726-bqlf72fe	139	13	separately	separately	RB
cord-007726-bqlf72fe	139	14	or	or	CC
cord-007726-bqlf72fe	139	15	in	in	IN
cord-007726-bqlf72fe	139	16	combination	combination	NN
cord-007726-bqlf72fe	139	17	.	.	.
cord-007726-bqlf72fe	140	1	COPD	COPD	NNP
cord-007726-bqlf72fe	140	2	is	be	VBZ
cord-007726-bqlf72fe	140	3	almost	almost	RB
cord-007726-bqlf72fe	140	4	always	always	RB
cord-007726-bqlf72fe	140	5	associated	associate	VBN
cord-007726-bqlf72fe	140	6	with	with	IN
cord-007726-bqlf72fe	140	7	either	either	DT
cord-007726-bqlf72fe	140	8	first	first	JJ
cord-007726-bqlf72fe	140	9	-	-	HYPH
cord-007726-bqlf72fe	140	10	or	or	CC
cord-007726-bqlf72fe	140	11	secondhand	secondhand	JJ
cord-007726-bqlf72fe	140	12	tobacco	tobacco	NN
cord-007726-bqlf72fe	140	13	smoking	smoking	NN
cord-007726-bqlf72fe	140	14	or	or	CC
cord-007726-bqlf72fe	140	15	in	in	IN
cord-007726-bqlf72fe	140	16	rare	rare	JJ
cord-007726-bqlf72fe	140	17	cases	case	NNS
cord-007726-bqlf72fe	140	18	with	with	IN
cord-007726-bqlf72fe	140	19	a	a	DT
cord-007726-bqlf72fe	140	20	deficiency	deficiency	NN
cord-007726-bqlf72fe	140	21	in	in	IN
cord-007726-bqlf72fe	140	22	the	the	DT
cord-007726-bqlf72fe	140	23	production	production	NN
cord-007726-bqlf72fe	140	24	of	of	IN
cord-007726-bqlf72fe	140	25	α1antitrypsin	α1antitrypsin	NNP
cord-007726-bqlf72fe	140	26	(	(	-LRB-
cord-007726-bqlf72fe	140	27	a	a	DT
cord-007726-bqlf72fe	140	28	serpin	serpin	NN
cord-007726-bqlf72fe	140	29	that	that	WDT
cord-007726-bqlf72fe	140	30	prevents	prevent	VBZ
cord-007726-bqlf72fe	140	31	elastin	elastin	NN
cord-007726-bqlf72fe	140	32	breakdown	breakdown	NN
cord-007726-bqlf72fe	140	33	as	as	IN
cord-007726-bqlf72fe	140	34	a	a	DT
cord-007726-bqlf72fe	140	35	result	result	NN
cord-007726-bqlf72fe	140	36	of	of	IN
cord-007726-bqlf72fe	140	37	neutrophil	neutrophil	NN
cord-007726-bqlf72fe	140	38	degranulation	degranulation	NN
cord-007726-bqlf72fe	140	39	)	)	-RRB-
cord-007726-bqlf72fe	140	40	[	[	-LRB-
cord-007726-bqlf72fe	140	41	50	50	CD
cord-007726-bqlf72fe	140	42	]	]	-RRB-
cord-007726-bqlf72fe	140	43	.	.	.
cord-007726-bqlf72fe	141	1	The	the	DT
cord-007726-bqlf72fe	141	2	etiology	etiology	NN
cord-007726-bqlf72fe	141	3	of	of	IN
cord-007726-bqlf72fe	141	4	COPD	COPD	NNP
cord-007726-bqlf72fe	141	5	is	be	VBZ
cord-007726-bqlf72fe	141	6	highly	highly	RB
cord-007726-bqlf72fe	141	7	complex	complex	JJ
cord-007726-bqlf72fe	141	8	and	and	CC
cord-007726-bqlf72fe	141	9	is	be	VBZ
cord-007726-bqlf72fe	141	10	believed	believe	VBN
cord-007726-bqlf72fe	141	11	to	to	TO
cord-007726-bqlf72fe	141	12	develop	develop	VB
cord-007726-bqlf72fe	141	13	after	after	IN
cord-007726-bqlf72fe	141	14	many	many	JJ
cord-007726-bqlf72fe	141	15	years	year	NNS
cord-007726-bqlf72fe	141	16	of	of	IN
cord-007726-bqlf72fe	141	17	smoking	smoking	NN
cord-007726-bqlf72fe	141	18	in	in	IN
cord-007726-bqlf72fe	141	19	combination	combination	NN
cord-007726-bqlf72fe	141	20	with	with	IN
cord-007726-bqlf72fe	141	21	other	other	JJ
cord-007726-bqlf72fe	141	22	known	know	VBN
cord-007726-bqlf72fe	141	23	factors	factor	NNS
cord-007726-bqlf72fe	141	24	such	such	JJ
cord-007726-bqlf72fe	141	25	as	as	IN
cord-007726-bqlf72fe	141	26	genetic	genetic	JJ
cord-007726-bqlf72fe	141	27	susceptibility	susceptibility	NN
cord-007726-bqlf72fe	141	28	or	or	CC
cord-007726-bqlf72fe	141	29	environmental	environmental	JJ
cord-007726-bqlf72fe	141	30	factors	factor	NNS
cord-007726-bqlf72fe	141	31	[	[	-LRB-
cord-007726-bqlf72fe	141	32	51	51	CD
cord-007726-bqlf72fe	141	33	]	]	-RRB-
cord-007726-bqlf72fe	141	34	.	.	.
cord-007726-bqlf72fe	142	1	In	in	IN
cord-007726-bqlf72fe	142	2	similarity	similarity	NN
cord-007726-bqlf72fe	142	3	to	to	IN
cord-007726-bqlf72fe	142	4	asthma	asthma	NN
cord-007726-bqlf72fe	142	5	,	,	,
cord-007726-bqlf72fe	142	6	inflammation	inflammation	NN
cord-007726-bqlf72fe	142	7	is	be	VBZ
cord-007726-bqlf72fe	142	8	a	a	DT
cord-007726-bqlf72fe	142	9	major	major	JJ
cord-007726-bqlf72fe	142	10	component	component	NN
cord-007726-bqlf72fe	142	11	in	in	IN
cord-007726-bqlf72fe	142	12	COPD	COPD	NNP
cord-007726-bqlf72fe	142	13	,	,	,
cord-007726-bqlf72fe	142	14	but	but	CC
cord-007726-bqlf72fe	142	15	the	the	DT
cord-007726-bqlf72fe	142	16	leukocyte	leukocyte	NN
cord-007726-bqlf72fe	142	17	profile	profile	NN
cord-007726-bqlf72fe	142	18	is	be	VBZ
cord-007726-bqlf72fe	142	19	very	very	RB
cord-007726-bqlf72fe	142	20	different	different	JJ
cord-007726-bqlf72fe	142	21	:	:	:
cord-007726-bqlf72fe	142	22	the	the	DT
cord-007726-bqlf72fe	142	23	most	most	RBS
cord-007726-bqlf72fe	142	24	prominent	prominent	JJ
cord-007726-bqlf72fe	142	25	players	player	NNS
cord-007726-bqlf72fe	142	26	in	in	IN
cord-007726-bqlf72fe	142	27	COPD	COPD	NNP
cord-007726-bqlf72fe	142	28	-	-	HYPH
cord-007726-bqlf72fe	142	29	related	relate	VBN
cord-007726-bqlf72fe	142	30	inflammation	inflammation	NN
cord-007726-bqlf72fe	142	31	are	be	VBP
cord-007726-bqlf72fe	142	32	neutrophils	neutrophil	NNS
cord-007726-bqlf72fe	142	33	and	and	CC
cord-007726-bqlf72fe	142	34	,	,	,
cord-007726-bqlf72fe	142	35	to	to	IN
cord-007726-bqlf72fe	142	36	some	some	DT
cord-007726-bqlf72fe	142	37	degree	degree	NN
cord-007726-bqlf72fe	142	38	,	,	,
cord-007726-bqlf72fe	142	39	macrophages	macrophage	NNS
cord-007726-bqlf72fe	142	40	[	[	-LRB-
cord-007726-bqlf72fe	142	41	51	51	CD
cord-007726-bqlf72fe	142	42	]	]	-RRB-
cord-007726-bqlf72fe	142	43	.	.	.
cord-007726-bqlf72fe	143	1	Due	due	IN
cord-007726-bqlf72fe	143	2	to	to	IN
cord-007726-bqlf72fe	143	3	the	the	DT
cord-007726-bqlf72fe	143	4	complex	complex	JJ
cord-007726-bqlf72fe	143	5	etiology	etiology	NN
cord-007726-bqlf72fe	143	6	of	of	IN
cord-007726-bqlf72fe	143	7	COPD	COPD	NNP
cord-007726-bqlf72fe	143	8	,	,	,
cord-007726-bqlf72fe	143	9	it	-PRON-	PRP
cord-007726-bqlf72fe	143	10	is	be	VBZ
cord-007726-bqlf72fe	143	11	difficult	difficult	JJ
cord-007726-bqlf72fe	143	12	to	to	TO
cord-007726-bqlf72fe	143	13	recapitulate	recapitulate	VB
cord-007726-bqlf72fe	143	14	all	all	DT
cord-007726-bqlf72fe	143	15	aspects	aspect	NNS
cord-007726-bqlf72fe	143	16	of	of	IN
cord-007726-bqlf72fe	143	17	this	this	DT
cord-007726-bqlf72fe	143	18	disease	disease	NN
cord-007726-bqlf72fe	143	19	in	in	IN
cord-007726-bqlf72fe	143	20	a	a	DT
cord-007726-bqlf72fe	143	21	single	single	JJ
cord-007726-bqlf72fe	143	22	model	model	NN
cord-007726-bqlf72fe	143	23	,	,	,
cord-007726-bqlf72fe	143	24	so	so	CC
cord-007726-bqlf72fe	143	25	in	in	IN
cord-007726-bqlf72fe	143	26	most	most	JJS
cord-007726-bqlf72fe	143	27	cases	case	NNS
cord-007726-bqlf72fe	143	28	,	,	,
cord-007726-bqlf72fe	143	29	the	the	DT
cord-007726-bqlf72fe	143	30	aim	aim	NN
cord-007726-bqlf72fe	143	31	is	be	VBZ
cord-007726-bqlf72fe	143	32	to	to	TO
cord-007726-bqlf72fe	143	33	induce	induce	VB
cord-007726-bqlf72fe	143	34	COPD	COPD	NNP
cord-007726-bqlf72fe	143	35	-	-	HYPH
cord-007726-bqlf72fe	143	36	like	like	JJ
cord-007726-bqlf72fe	143	37	lesions	lesion	NNS
cord-007726-bqlf72fe	143	38	by	by	IN
cord-007726-bqlf72fe	143	39	exposing	expose	VBG
cord-007726-bqlf72fe	143	40	mice	mouse	NNS
cord-007726-bqlf72fe	143	41	to	to	IN
cord-007726-bqlf72fe	143	42	tissue	tissue	NN
cord-007726-bqlf72fe	143	43	-	-	HYPH
cord-007726-bqlf72fe	143	44	damaging	damage	VBG
cord-007726-bqlf72fe	143	45	substances	substance	NNS
cord-007726-bqlf72fe	143	46	(	(	-LRB-
cord-007726-bqlf72fe	143	47	usually	usually	RB
cord-007726-bqlf72fe	143	48	cigarette	cigarette	NN
cord-007726-bqlf72fe	143	49	smoke	smoke	NN
cord-007726-bqlf72fe	143	50	)	)	-RRB-
cord-007726-bqlf72fe	143	51	or	or	CC
cord-007726-bqlf72fe	143	52	to	to	TO
cord-007726-bqlf72fe	143	53	mimic	mimic	VB
cord-007726-bqlf72fe	143	54	emphysema	emphysema	NN
cord-007726-bqlf72fe	143	55	by	by	IN
cord-007726-bqlf72fe	143	56	the	the	DT
cord-007726-bqlf72fe	143	57	administration	administration	NN
cord-007726-bqlf72fe	143	58	of	of	IN
cord-007726-bqlf72fe	143	59	tissue	tissue	NN
cord-007726-bqlf72fe	143	60	-	-	HYPH
cord-007726-bqlf72fe	143	61	degrading	degrade	VBG
cord-007726-bqlf72fe	143	62	enzymes	enzyme	NNS
cord-007726-bqlf72fe	143	63	[	[	-LRB-
cord-007726-bqlf72fe	143	64	27	27	CD
cord-007726-bqlf72fe	143	65	,	,	,
cord-007726-bqlf72fe	143	66	51	51	CD
cord-007726-bqlf72fe	143	67	]	]	-RRB-
cord-007726-bqlf72fe	143	68	.	.	.
cord-007726-bqlf72fe	144	1	Clearly	clearly	RB
cord-007726-bqlf72fe	144	2	,	,	,
cord-007726-bqlf72fe	144	3	mice	mouse	NNS
cord-007726-bqlf72fe	144	4	do	do	VBP
cord-007726-bqlf72fe	144	5	not	not	RB
cord-007726-bqlf72fe	144	6	smoke	smoke	VB
cord-007726-bqlf72fe	144	7	cigarettes	cigarette	NNS
cord-007726-bqlf72fe	144	8	on	on	IN
cord-007726-bqlf72fe	144	9	their	-PRON-	PRP$
cord-007726-bqlf72fe	144	10	own	own	JJ
cord-007726-bqlf72fe	144	11	,	,	,
cord-007726-bqlf72fe	144	12	so	so	RB
cord-007726-bqlf72fe	144	13	to	to	TO
cord-007726-bqlf72fe	144	14	model	model	VB
cord-007726-bqlf72fe	144	15	COPD	COPD	NNP
cord-007726-bqlf72fe	144	16	by	by	IN
cord-007726-bqlf72fe	144	17	cigarette	cigarette	NN
cord-007726-bqlf72fe	144	18	smoke	smoke	NN
cord-007726-bqlf72fe	144	19	(	(	-LRB-
cord-007726-bqlf72fe	144	20	CS	CS	NNP
cord-007726-bqlf72fe	144	21	)	)	-RRB-
cord-007726-bqlf72fe	144	22	inhalation	inhalation	NN
cord-007726-bqlf72fe	144	23	,	,	,
cord-007726-bqlf72fe	144	24	the	the	DT
cord-007726-bqlf72fe	144	25	mice	mice	NN
cord-007726-bqlf72fe	144	26	need	need	VBP
cord-007726-bqlf72fe	144	27	to	to	TO
cord-007726-bqlf72fe	144	28	be	be	VB
cord-007726-bqlf72fe	144	29	exposed	expose	VBN
cord-007726-bqlf72fe	144	30	to	to	IN
cord-007726-bqlf72fe	144	31	unfiltered	unfiltered	JJ
cord-007726-bqlf72fe	144	32	CS	cs	NN
cord-007726-bqlf72fe	144	33	in	in	IN
cord-007726-bqlf72fe	144	34	an	an	DT
cord-007726-bqlf72fe	144	35	induction	induction	NN
cord-007726-bqlf72fe	144	36	chamber	chamber	NN
cord-007726-bqlf72fe	144	37	;	;	:
cord-007726-bqlf72fe	144	38	moreover	moreover	RB
cord-007726-bqlf72fe	144	39	,	,	,
cord-007726-bqlf72fe	144	40	in	in	IN
cord-007726-bqlf72fe	144	41	an	an	DT
cord-007726-bqlf72fe	144	42	attempt	attempt	NN
cord-007726-bqlf72fe	144	43	to	to	TO
cord-007726-bqlf72fe	144	44	better	well	RBR
cord-007726-bqlf72fe	144	45	model	model	VB
cord-007726-bqlf72fe	144	46	the	the	DT
cord-007726-bqlf72fe	144	47	chronic	chronic	JJ
cord-007726-bqlf72fe	144	48	aspects	aspect	NNS
cord-007726-bqlf72fe	144	49	of	of	IN
cord-007726-bqlf72fe	144	50	COPD	COPD	NNP
cord-007726-bqlf72fe	144	51	,	,	,
cord-007726-bqlf72fe	144	52	this	this	DT
cord-007726-bqlf72fe	144	53	needs	need	VBZ
cord-007726-bqlf72fe	144	54	to	to	TO
cord-007726-bqlf72fe	144	55	be	be	VB
cord-007726-bqlf72fe	144	56	performed	perform	VBN
cord-007726-bqlf72fe	144	57	for	for	IN
cord-007726-bqlf72fe	144	58	a	a	DT
cord-007726-bqlf72fe	144	59	prolonged	prolonged	JJ
cord-007726-bqlf72fe	144	60	period	period	NN
cord-007726-bqlf72fe	144	61	of	of	IN
cord-007726-bqlf72fe	144	62	time	time	NN
cord-007726-bqlf72fe	144	63	.	.	.
cord-007726-bqlf72fe	145	1	Mice	mouse	NNS
cord-007726-bqlf72fe	145	2	are	be	VBP
cord-007726-bqlf72fe	145	3	very	very	RB
cord-007726-bqlf72fe	145	4	tolerant	tolerant	JJ
cord-007726-bqlf72fe	145	5	to	to	IN
cord-007726-bqlf72fe	145	6	CS	CS	NNP
cord-007726-bqlf72fe	145	7	,	,	,
cord-007726-bqlf72fe	145	8	but	but	CC
cord-007726-bqlf72fe	145	9	eventually	eventually	RB
cord-007726-bqlf72fe	145	10	(	(	-LRB-
cord-007726-bqlf72fe	145	11	over	over	IN
cord-007726-bqlf72fe	145	12	a	a	DT
cord-007726-bqlf72fe	145	13	period	period	NN
cord-007726-bqlf72fe	145	14	of	of	IN
cord-007726-bqlf72fe	145	15	several	several	JJ
cord-007726-bqlf72fe	145	16	weeks	week	NNS
cord-007726-bqlf72fe	145	17	)	)	-RRB-
cord-007726-bqlf72fe	145	18	,	,	,
cord-007726-bqlf72fe	145	19	CS	CS	NNP
cord-007726-bqlf72fe	145	20	induces	induce	VBZ
cord-007726-bqlf72fe	145	21	pulmonary	pulmonary	JJ
cord-007726-bqlf72fe	145	22	neutrophilic	neutrophilic	JJ
cord-007726-bqlf72fe	145	23	inflammation	inflammation	NN
cord-007726-bqlf72fe	145	24	that	that	WDT
cord-007726-bqlf72fe	145	25	is	be	VBZ
cord-007726-bqlf72fe	145	26	associated	associate	VBN
cord-007726-bqlf72fe	145	27	with	with	IN
cord-007726-bqlf72fe	145	28	some	some	DT
cord-007726-bqlf72fe	145	29	degree	degree	NN
cord-007726-bqlf72fe	145	30	of	of	IN
cord-007726-bqlf72fe	145	31	tissue	tissue	NN
cord-007726-bqlf72fe	145	32	degradation	degradation	NN
cord-007726-bqlf72fe	145	33	and	and	CC
cord-007726-bqlf72fe	145	34	destruction	destruction	NN
cord-007726-bqlf72fe	145	35	[	[	-LRB-
cord-007726-bqlf72fe	145	36	51	51	CD
cord-007726-bqlf72fe	145	37	]	]	-RRB-
cord-007726-bqlf72fe	145	38	.	.	.
cord-007726-bqlf72fe	146	1	An	an	DT
cord-007726-bqlf72fe	146	2	important	important	JJ
cord-007726-bqlf72fe	146	3	advantage	advantage	NN
cord-007726-bqlf72fe	146	4	of	of	IN
cord-007726-bqlf72fe	146	5	this	this	DT
cord-007726-bqlf72fe	146	6	model	model	NN
cord-007726-bqlf72fe	146	7	is	be	VBZ
cord-007726-bqlf72fe	146	8	the	the	DT
cord-007726-bqlf72fe	146	9	fact	fact	NN
cord-007726-bqlf72fe	146	10	that	that	IN
cord-007726-bqlf72fe	146	11	CS	CS	NNP
cord-007726-bqlf72fe	146	12	is	be	VBZ
cord-007726-bqlf72fe	146	13	the	the	DT
cord-007726-bqlf72fe	146	14	actual	actual	JJ
cord-007726-bqlf72fe	146	15	irritant	irritant	NN
cord-007726-bqlf72fe	146	16	responsible	responsible	JJ
cord-007726-bqlf72fe	146	17	for	for	IN
cord-007726-bqlf72fe	146	18	disease	disease	NN
cord-007726-bqlf72fe	146	19	in	in	IN
cord-007726-bqlf72fe	146	20	humans	human	NNS
cord-007726-bqlf72fe	146	21	,	,	,
cord-007726-bqlf72fe	146	22	and	and	CC
cord-007726-bqlf72fe	146	23	mice	mouse	NNS
cord-007726-bqlf72fe	146	24	develop	develop	VBP
cord-007726-bqlf72fe	146	25	several	several	JJ
cord-007726-bqlf72fe	146	26	features	feature	NNS
cord-007726-bqlf72fe	146	27	similar	similar	JJ
cord-007726-bqlf72fe	146	28	to	to	IN
cord-007726-bqlf72fe	146	29	the	the	DT
cord-007726-bqlf72fe	146	30	clinical	clinical	JJ
cord-007726-bqlf72fe	146	31	disease	disease	NN
cord-007726-bqlf72fe	146	32	,	,	,
cord-007726-bqlf72fe	146	33	making	make	VBG
cord-007726-bqlf72fe	146	34	this	this	DT
cord-007726-bqlf72fe	146	35	model	model	NN
cord-007726-bqlf72fe	146	36	highly	highly	RB
cord-007726-bqlf72fe	146	37	clinically	clinically	RB
cord-007726-bqlf72fe	146	38	relevant	relevant	JJ
cord-007726-bqlf72fe	146	39	[	[	-LRB-
cord-007726-bqlf72fe	146	40	27	27	CD
cord-007726-bqlf72fe	146	41	]	]	-RRB-
cord-007726-bqlf72fe	146	42	.	.	.
cord-007726-bqlf72fe	147	1	A	a	DT
cord-007726-bqlf72fe	147	2	significant	significant	JJ
cord-007726-bqlf72fe	147	3	drawback	drawback	NN
cord-007726-bqlf72fe	147	4	is	be	VBZ
cord-007726-bqlf72fe	147	5	the	the	DT
cord-007726-bqlf72fe	147	6	self	self	NN
cord-007726-bqlf72fe	147	7	-	-	HYPH
cord-007726-bqlf72fe	147	8	limitation	limitation	NN
cord-007726-bqlf72fe	147	9	of	of	IN
cord-007726-bqlf72fe	147	10	the	the	DT
cord-007726-bqlf72fe	147	11	model	model	NN
cord-007726-bqlf72fe	147	12	-	-	:
cord-007726-bqlf72fe	147	13	the	the	DT
cord-007726-bqlf72fe	147	14	pathological	pathological	JJ
cord-007726-bqlf72fe	147	15	changes	change	NNS
cord-007726-bqlf72fe	147	16	do	do	VBP
cord-007726-bqlf72fe	147	17	not	not	RB
cord-007726-bqlf72fe	147	18	progress	progress	VB
cord-007726-bqlf72fe	147	19	after	after	IN
cord-007726-bqlf72fe	147	20	the	the	DT
cord-007726-bqlf72fe	147	21	cessation	cessation	NN
cord-007726-bqlf72fe	147	22	of	of	IN
cord-007726-bqlf72fe	147	23	CS	CS	NNP
cord-007726-bqlf72fe	147	24	exposure	exposure	NN
cord-007726-bqlf72fe	147	25	[	[	-LRB-
cord-007726-bqlf72fe	147	26	51	51	CD
cord-007726-bqlf72fe	147	27	]	]	-RRB-
cord-007726-bqlf72fe	147	28	.	.	.
cord-007726-bqlf72fe	148	1	Furthermore	furthermore	RB
cord-007726-bqlf72fe	148	2	,	,	,
cord-007726-bqlf72fe	148	3	the	the	DT
cord-007726-bqlf72fe	148	4	exposure	exposure	NN
cord-007726-bqlf72fe	148	5	time	time	NN
cord-007726-bqlf72fe	148	6	needed	need	VBN
cord-007726-bqlf72fe	148	7	for	for	IN
cord-007726-bqlf72fe	148	8	mice	mouse	NNS
cord-007726-bqlf72fe	148	9	to	to	TO
cord-007726-bqlf72fe	148	10	develop	develop	VB
cord-007726-bqlf72fe	148	11	COPD	COPD	NNP
cord-007726-bqlf72fe	148	12	-	-	HYPH
cord-007726-bqlf72fe	148	13	like	like	JJ
cord-007726-bqlf72fe	148	14	pathology	pathology	NN
cord-007726-bqlf72fe	148	15	is	be	VBZ
cord-007726-bqlf72fe	148	16	extensive	extensive	JJ
cord-007726-bqlf72fe	148	17	,	,	,
cord-007726-bqlf72fe	148	18	i.e.	i.e.	FW
cord-007726-bqlf72fe	148	19	,	,	,
cord-007726-bqlf72fe	148	20	studies	study	NNS
cord-007726-bqlf72fe	148	21	have	have	VBP
cord-007726-bqlf72fe	148	22	shown	show	VBN
cord-007726-bqlf72fe	148	23	that	that	IN
cord-007726-bqlf72fe	148	24	an	an	DT
cord-007726-bqlf72fe	148	25	exposure	exposure	NN
cord-007726-bqlf72fe	148	26	protocol	protocol	NN
cord-007726-bqlf72fe	148	27	of	of	IN
cord-007726-bqlf72fe	148	28	5	5	CD
cord-007726-bqlf72fe	148	29	days	day	NNS
cord-007726-bqlf72fe	148	30	per	per	IN
cord-007726-bqlf72fe	148	31	week	week	NN
cord-007726-bqlf72fe	148	32	for	for	IN
cord-007726-bqlf72fe	148	33	a	a	DT
cord-007726-bqlf72fe	148	34	minimum	minimum	NN
cord-007726-bqlf72fe	148	35	of	of	IN
cord-007726-bqlf72fe	148	36	3	3	CD
cord-007726-bqlf72fe	148	37	months	month	NNS
cord-007726-bqlf72fe	148	38	is	be	VBZ
cord-007726-bqlf72fe	148	39	needed	need	VBN
cord-007726-bqlf72fe	148	40	to	to	TO
cord-007726-bqlf72fe	148	41	generate	generate	VB
cord-007726-bqlf72fe	148	42	robust	robust	JJ
cord-007726-bqlf72fe	148	43	structural	structural	JJ
cord-007726-bqlf72fe	148	44	changes	change	NNS
cord-007726-bqlf72fe	148	45	to	to	IN
cord-007726-bqlf72fe	148	46	the	the	DT
cord-007726-bqlf72fe	148	47	lung	lung	NN
cord-007726-bqlf72fe	148	48	[	[	-LRB-
cord-007726-bqlf72fe	148	49	52	52	CD
cord-007726-bqlf72fe	148	50	]	]	-RRB-
cord-007726-bqlf72fe	148	51	.	.	.
cord-007726-bqlf72fe	149	1	The	the	DT
cord-007726-bqlf72fe	149	2	pathological	pathological	JJ
cord-007726-bqlf72fe	149	3	image	image	NN
cord-007726-bqlf72fe	149	4	in	in	IN
cord-007726-bqlf72fe	149	5	COPD	COPD	NNP
cord-007726-bqlf72fe	149	6	is	be	VBZ
cord-007726-bqlf72fe	149	7	complex	complex	JJ
cord-007726-bqlf72fe	149	8	and	and	CC
cord-007726-bqlf72fe	149	9	varies	vary	VBZ
cord-007726-bqlf72fe	149	10	greatly	greatly	RB
cord-007726-bqlf72fe	149	11	between	between	IN
cord-007726-bqlf72fe	149	12	patients	patient	NNS
cord-007726-bqlf72fe	149	13	,	,	,
cord-007726-bqlf72fe	149	14	commonly	commonly	RB
cord-007726-bqlf72fe	149	15	encompassing	encompass	VBG
cord-007726-bqlf72fe	149	16	chronic	chronic	JJ
cord-007726-bqlf72fe	149	17	bronchitis	bronchitis	NN
cord-007726-bqlf72fe	149	18	and	and	CC
cord-007726-bqlf72fe	149	19	bronchiolitis	bronchiolitis	NN
cord-007726-bqlf72fe	149	20	,	,	,
cord-007726-bqlf72fe	149	21	emphysema	emphysema	NN
cord-007726-bqlf72fe	149	22	,	,	,
cord-007726-bqlf72fe	149	23	fibrosis	fibrosis	NN
cord-007726-bqlf72fe	149	24	,	,	,
cord-007726-bqlf72fe	149	25	and	and	CC
cord-007726-bqlf72fe	149	26	airway	airway	NN
cord-007726-bqlf72fe	149	27	obstruction	obstruction	NN
cord-007726-bqlf72fe	149	28	.	.	.
cord-007726-bqlf72fe	150	1	Although	although	IN
cord-007726-bqlf72fe	150	2	mice	mouse	NNS
cord-007726-bqlf72fe	150	3	develop	develop	VBP
cord-007726-bqlf72fe	150	4	some	some	DT
cord-007726-bqlf72fe	150	5	of	of	IN
cord-007726-bqlf72fe	150	6	these	these	DT
cord-007726-bqlf72fe	150	7	symptoms	symptom	NNS
cord-007726-bqlf72fe	150	8	when	when	WRB
cord-007726-bqlf72fe	150	9	exposed	expose	VBN
cord-007726-bqlf72fe	150	10	to	to	IN
cord-007726-bqlf72fe	150	11	CS	CS	NNP
cord-007726-bqlf72fe	150	12	,	,	,
cord-007726-bqlf72fe	150	13	they	-PRON-	PRP
cord-007726-bqlf72fe	150	14	do	do	VBP
cord-007726-bqlf72fe	150	15	not	not	RB
cord-007726-bqlf72fe	150	16	develop	develop	VB
cord-007726-bqlf72fe	150	17	all	all	PDT
cord-007726-bqlf72fe	150	18	the	the	DT
cord-007726-bqlf72fe	150	19	symptoms	symptom	NNS
cord-007726-bqlf72fe	150	20	of	of	IN
cord-007726-bqlf72fe	150	21	human	human	JJ
cord-007726-bqlf72fe	150	22	disease	disease	NN
cord-007726-bqlf72fe	150	23	;	;	:
cord-007726-bqlf72fe	150	24	thus	thus	RB
cord-007726-bqlf72fe	150	25	,	,	,
cord-007726-bqlf72fe	150	26	CS	CS	NNP
cord-007726-bqlf72fe	150	27	has	have	VBZ
cord-007726-bqlf72fe	150	28	advantages	advantage	NNS
cord-007726-bqlf72fe	150	29	as	as	IN
cord-007726-bqlf72fe	150	30	a	a	DT
cord-007726-bqlf72fe	150	31	model	model	NN
cord-007726-bqlf72fe	150	32	but	but	CC
cord-007726-bqlf72fe	150	33	fails	fail	VBZ
cord-007726-bqlf72fe	150	34	to	to	TO
cord-007726-bqlf72fe	150	35	mimic	mimic	VB
cord-007726-bqlf72fe	150	36	the	the	DT
cord-007726-bqlf72fe	150	37	complexity	complexity	NN
cord-007726-bqlf72fe	150	38	of	of	IN
cord-007726-bqlf72fe	150	39	the	the	DT
cord-007726-bqlf72fe	150	40	clinical	clinical	JJ
cord-007726-bqlf72fe	150	41	situation	situation	NN
cord-007726-bqlf72fe	150	42	and	and	CC
cord-007726-bqlf72fe	150	43	disease	disease	NN
cord-007726-bqlf72fe	150	44	presentation	presentation	NN
cord-007726-bqlf72fe	150	45	[	[	-LRB-
cord-007726-bqlf72fe	150	46	27	27	CD
cord-007726-bqlf72fe	150	47	]	]	-RRB-
cord-007726-bqlf72fe	150	48	.	.	.
cord-007726-bqlf72fe	151	1	Other	other	JJ
cord-007726-bqlf72fe	151	2	models	model	NNS
cord-007726-bqlf72fe	151	3	of	of	IN
cord-007726-bqlf72fe	151	4	COPD	COPD	NNP
cord-007726-bqlf72fe	151	5	rely	rely	VBP
cord-007726-bqlf72fe	151	6	on	on	IN
cord-007726-bqlf72fe	151	7	the	the	DT
cord-007726-bqlf72fe	151	8	administration	administration	NN
cord-007726-bqlf72fe	151	9	of	of	IN
cord-007726-bqlf72fe	151	10	proteases	protease	NNS
cord-007726-bqlf72fe	151	11	(	(	-LRB-
cord-007726-bqlf72fe	151	12	protein	protein	NN
cord-007726-bqlf72fe	151	13	-	-	HYPH
cord-007726-bqlf72fe	151	14	degrading	degrade	VBG
cord-007726-bqlf72fe	151	15	enzymes	enzyme	NNS
cord-007726-bqlf72fe	151	16	)	)	-RRB-
cord-007726-bqlf72fe	151	17	that	that	WDT
cord-007726-bqlf72fe	151	18	are	be	VBP
cord-007726-bqlf72fe	151	19	believed	believe	VBN
cord-007726-bqlf72fe	151	20	to	to	TO
cord-007726-bqlf72fe	151	21	be	be	VB
cord-007726-bqlf72fe	151	22	involved	involve	VBN
cord-007726-bqlf72fe	151	23	in	in	IN
cord-007726-bqlf72fe	151	24	the	the	DT
cord-007726-bqlf72fe	151	25	pathology	pathology	NN
cord-007726-bqlf72fe	151	26	of	of	IN
cord-007726-bqlf72fe	151	27	this	this	DT
cord-007726-bqlf72fe	151	28	disease	disease	NN
cord-007726-bqlf72fe	151	29	in	in	IN
cord-007726-bqlf72fe	151	30	a	a	DT
cord-007726-bqlf72fe	151	31	subset	subset	NN
cord-007726-bqlf72fe	151	32	of	of	IN
cord-007726-bqlf72fe	151	33	patients	patient	NNS
cord-007726-bqlf72fe	151	34	,	,	,
cord-007726-bqlf72fe	151	35	such	such	JJ
cord-007726-bqlf72fe	151	36	as	as	IN
cord-007726-bqlf72fe	151	37	elastindegrading	elastindegrade	VBG
cord-007726-bqlf72fe	151	38	elastase	elastase	NN
cord-007726-bqlf72fe	151	39	.	.	.
cord-007726-bqlf72fe	152	1	This	this	DT
cord-007726-bqlf72fe	152	2	approach	approach	NN
cord-007726-bqlf72fe	152	3	mimics	mimic	VBZ
cord-007726-bqlf72fe	152	4	the	the	DT
cord-007726-bqlf72fe	152	5	emphysematous	emphysematous	JJ
cord-007726-bqlf72fe	152	6	changes	change	NNS
cord-007726-bqlf72fe	152	7	seen	see	VBN
cord-007726-bqlf72fe	152	8	in	in	IN
cord-007726-bqlf72fe	152	9	COPD	COPD	NNP
cord-007726-bqlf72fe	152	10	,	,	,
cord-007726-bqlf72fe	152	11	but	but	CC
cord-007726-bqlf72fe	152	12	the	the	DT
cord-007726-bqlf72fe	152	13	pathological	pathological	JJ
cord-007726-bqlf72fe	152	14	process	process	NN
cord-007726-bqlf72fe	152	15	underlying	underlie	VBG
cord-007726-bqlf72fe	152	16	tissue	tissue	NN
cord-007726-bqlf72fe	152	17	destruction	destruction	NN
cord-007726-bqlf72fe	152	18	is	be	VBZ
cord-007726-bqlf72fe	152	19	likely	likely	RB
cord-007726-bqlf72fe	152	20	very	very	RB
cord-007726-bqlf72fe	152	21	different	different	JJ
cord-007726-bqlf72fe	152	22	compared	compare	VBN
cord-007726-bqlf72fe	152	23	to	to	IN
cord-007726-bqlf72fe	152	24	the	the	DT
cord-007726-bqlf72fe	152	25	clinical	clinical	JJ
cord-007726-bqlf72fe	152	26	situation	situation	NN
cord-007726-bqlf72fe	152	27	[	[	-LRB-
cord-007726-bqlf72fe	152	28	51	51	CD
cord-007726-bqlf72fe	152	29	]	]	-RRB-
cord-007726-bqlf72fe	152	30	,	,	,
cord-007726-bqlf72fe	152	31	as	as	IN
cord-007726-bqlf72fe	152	32	very	very	RB
cord-007726-bqlf72fe	152	33	few	few	JJ
cord-007726-bqlf72fe	152	34	patients	patient	NNS
cord-007726-bqlf72fe	152	35	show	show	VBP
cord-007726-bqlf72fe	152	36	evidence	evidence	NN
cord-007726-bqlf72fe	152	37	of	of	IN
cord-007726-bqlf72fe	152	38	elastase	elastase	NN
cord-007726-bqlf72fe	152	39	dysregulation	dysregulation	NN
cord-007726-bqlf72fe	152	40	[	[	-LRB-
cord-007726-bqlf72fe	152	41	27	27	CD
cord-007726-bqlf72fe	152	42	]	]	-RRB-
cord-007726-bqlf72fe	152	43	.	.	.
cord-007726-bqlf72fe	153	1	However	however	RB
cord-007726-bqlf72fe	153	2	,	,	,
cord-007726-bqlf72fe	153	3	if	if	IN
cord-007726-bqlf72fe	153	4	the	the	DT
cord-007726-bqlf72fe	153	5	aim	aim	NN
cord-007726-bqlf72fe	153	6	of	of	IN
cord-007726-bqlf72fe	153	7	the	the	DT
cord-007726-bqlf72fe	153	8	study	study	NN
cord-007726-bqlf72fe	153	9	is	be	VBZ
cord-007726-bqlf72fe	153	10	to	to	TO
cord-007726-bqlf72fe	153	11	investigate	investigate	VB
cord-007726-bqlf72fe	153	12	the	the	DT
cord-007726-bqlf72fe	153	13	general	general	JJ
cord-007726-bqlf72fe	153	14	effect	effect	NN
cord-007726-bqlf72fe	153	15	of	of	IN
cord-007726-bqlf72fe	153	16	protease	protease	NN
cord-007726-bqlf72fe	153	17	-	-	HYPH
cord-007726-bqlf72fe	153	18	induced	induce	VBN
cord-007726-bqlf72fe	153	19	tissue	tissue	NN
cord-007726-bqlf72fe	153	20	destruction	destruction	NN
cord-007726-bqlf72fe	153	21	and	and	CC
cord-007726-bqlf72fe	153	22	regeneration	regeneration	NN
cord-007726-bqlf72fe	153	23	,	,	,
cord-007726-bqlf72fe	153	24	then	then	RB
cord-007726-bqlf72fe	153	25	this	this	DT
cord-007726-bqlf72fe	153	26	is	be	VBZ
cord-007726-bqlf72fe	153	27	a	a	DT
cord-007726-bqlf72fe	153	28	highly	highly	RB
cord-007726-bqlf72fe	153	29	relevant	relevant	JJ
cord-007726-bqlf72fe	153	30	method	method	NN
cord-007726-bqlf72fe	153	31	[	[	-LRB-
cord-007726-bqlf72fe	153	32	51	51	CD
cord-007726-bqlf72fe	153	33	]	]	-RRB-
cord-007726-bqlf72fe	153	34	.	.	.
cord-007726-bqlf72fe	154	1	Some	some	DT
cord-007726-bqlf72fe	154	2	studies	study	NNS
cord-007726-bqlf72fe	154	3	on	on	IN
cord-007726-bqlf72fe	154	4	COPD	COPD	NNP
cord-007726-bqlf72fe	154	5	have	have	VBP
cord-007726-bqlf72fe	154	6	also	also	RB
cord-007726-bqlf72fe	154	7	used	use	VBN
cord-007726-bqlf72fe	154	8	genetically	genetically	RB
cord-007726-bqlf72fe	154	9	modified	modify	VBN
cord-007726-bqlf72fe	154	10	animals	animal	NNS
cord-007726-bqlf72fe	154	11	,	,	,
cord-007726-bqlf72fe	154	12	such	such	JJ
cord-007726-bqlf72fe	154	13	as	as	IN
cord-007726-bqlf72fe	154	14	mice	mouse	NNS
cord-007726-bqlf72fe	154	15	overexpressing	overexpressing	NNP
cord-007726-bqlf72fe	154	16	collagenase	collagenase	NNP
cord-007726-bqlf72fe	154	17	,	,	,
cord-007726-bqlf72fe	154	18	which	which	WDT
cord-007726-bqlf72fe	154	19	results	result	VBZ
cord-007726-bqlf72fe	154	20	in	in	IN
cord-007726-bqlf72fe	154	21	tissue	tissue	NN
cord-007726-bqlf72fe	154	22	destruction	destruction	NN
cord-007726-bqlf72fe	154	23	without	without	IN
cord-007726-bqlf72fe	154	24	inflammation	inflammation	NN
cord-007726-bqlf72fe	154	25	or	or	CC
cord-007726-bqlf72fe	154	26	fibrosis	fibrosis	NN
cord-007726-bqlf72fe	154	27	with	with	IN
cord-007726-bqlf72fe	154	28	an	an	DT
cord-007726-bqlf72fe	154	29	end	end	NN
cord-007726-bqlf72fe	154	30	result	result	NN
cord-007726-bqlf72fe	154	31	fairly	fairly	RB
cord-007726-bqlf72fe	154	32	similar	similar	JJ
cord-007726-bqlf72fe	154	33	to	to	IN
cord-007726-bqlf72fe	154	34	the	the	DT
cord-007726-bqlf72fe	154	35	type	type	NN
cord-007726-bqlf72fe	154	36	of	of	IN
cord-007726-bqlf72fe	154	37	emphysema	emphysema	NN
cord-007726-bqlf72fe	154	38	observed	observe	VBN
cord-007726-bqlf72fe	154	39	in	in	IN
cord-007726-bqlf72fe	154	40	COPD	COPD	NNP
cord-007726-bqlf72fe	154	41	[	[	-LRB-
cord-007726-bqlf72fe	154	42	53	53	CD
cord-007726-bqlf72fe	154	43	]	]	-RRB-
cord-007726-bqlf72fe	154	44	.	.	.
cord-007726-bqlf72fe	155	1	Pulmonary	pulmonary	JJ
cord-007726-bqlf72fe	155	2	fibrosis	fibrosis	NN
cord-007726-bqlf72fe	155	3	,	,	,
cord-007726-bqlf72fe	155	4	the	the	DT
cord-007726-bqlf72fe	155	5	accumulation	accumulation	NN
cord-007726-bqlf72fe	155	6	of	of	IN
cord-007726-bqlf72fe	155	7	fibrotic	fibrotic	JJ
cord-007726-bqlf72fe	155	8	tissue	tissue	NN
cord-007726-bqlf72fe	155	9	within	within	IN
cord-007726-bqlf72fe	155	10	the	the	DT
cord-007726-bqlf72fe	155	11	alveolar	alveolar	JJ
cord-007726-bqlf72fe	155	12	parenchyma	parenchyma	NN
cord-007726-bqlf72fe	155	13	,	,	,
cord-007726-bqlf72fe	155	14	is	be	VBZ
cord-007726-bqlf72fe	155	15	merely	merely	RB
cord-007726-bqlf72fe	155	16	a	a	DT
cord-007726-bqlf72fe	155	17	symptom	symptom	NN
cord-007726-bqlf72fe	155	18	of	of	IN
cord-007726-bqlf72fe	155	19	disease	disease	NN
cord-007726-bqlf72fe	155	20	,	,	,
cord-007726-bqlf72fe	155	21	and	and	CC
cord-007726-bqlf72fe	155	22	the	the	DT
cord-007726-bqlf72fe	155	23	etiology	etiology	NN
cord-007726-bqlf72fe	155	24	of	of	IN
cord-007726-bqlf72fe	155	25	this	this	DT
cord-007726-bqlf72fe	155	26	pathology	pathology	NN
cord-007726-bqlf72fe	155	27	in	in	IN
cord-007726-bqlf72fe	155	28	humans	human	NNS
cord-007726-bqlf72fe	155	29	varies	vary	VBZ
cord-007726-bqlf72fe	155	30	greatly	greatly	RB
cord-007726-bqlf72fe	155	31	[	[	-LRB-
cord-007726-bqlf72fe	155	32	54	54	CD
cord-007726-bqlf72fe	155	33	]	]	-RRB-
cord-007726-bqlf72fe	155	34	.	.	.
cord-007726-bqlf72fe	156	1	The	the	DT
cord-007726-bqlf72fe	156	2	most	most	RBS
cord-007726-bqlf72fe	156	3	enigmatic	enigmatic	JJ
cord-007726-bqlf72fe	156	4	class	class	NN
cord-007726-bqlf72fe	156	5	is	be	VBZ
cord-007726-bqlf72fe	156	6	perhaps	perhaps	RB
cord-007726-bqlf72fe	156	7	the	the	DT
cord-007726-bqlf72fe	156	8	idiopathic	idiopathic	JJ
cord-007726-bqlf72fe	156	9	interstitial	interstitial	JJ
cord-007726-bqlf72fe	156	10	pneumonias	pneumonia	NNS
cord-007726-bqlf72fe	156	11	,	,	,
cord-007726-bqlf72fe	156	12	especially	especially	RB
cord-007726-bqlf72fe	156	13	idiopathic	idiopathic	JJ
cord-007726-bqlf72fe	156	14	pulmonary	pulmonary	JJ
cord-007726-bqlf72fe	156	15	fibrosis	fibrosis	NN
cord-007726-bqlf72fe	156	16	(	(	-LRB-
cord-007726-bqlf72fe	156	17	IPF	IPF	NNP
cord-007726-bqlf72fe	156	18	)	)	-RRB-
cord-007726-bqlf72fe	156	19	.	.	.
cord-007726-bqlf72fe	157	1	IPF	IPF	NNP
cord-007726-bqlf72fe	157	2	is	be	VBZ
cord-007726-bqlf72fe	157	3	a	a	DT
cord-007726-bqlf72fe	157	4	debilitating	debilitating	JJ
cord-007726-bqlf72fe	157	5	and	and	CC
cord-007726-bqlf72fe	157	6	progressive	progressive	JJ
cord-007726-bqlf72fe	157	7	disease	disease	NN
cord-007726-bqlf72fe	157	8	with	with	IN
cord-007726-bqlf72fe	157	9	a	a	DT
cord-007726-bqlf72fe	157	10	grave	grave	JJ
cord-007726-bqlf72fe	157	11	prognosis	prognosis	NN
cord-007726-bqlf72fe	157	12	,	,	,
cord-007726-bqlf72fe	157	13	characterized	characterize	VBN
cord-007726-bqlf72fe	157	14	by	by	IN
cord-007726-bqlf72fe	157	15	progressive	progressive	JJ
cord-007726-bqlf72fe	157	16	fibrosis	fibrosis	NN
cord-007726-bqlf72fe	157	17	believed	believe	VBN
cord-007726-bqlf72fe	157	18	to	to	TO
cord-007726-bqlf72fe	157	19	reflect	reflect	VB
cord-007726-bqlf72fe	157	20	aberrant	aberrant	JJ
cord-007726-bqlf72fe	157	21	tissue	tissue	NN
cord-007726-bqlf72fe	157	22	regeneration	regeneration	NN
cord-007726-bqlf72fe	157	23	[	[	-LRB-
cord-007726-bqlf72fe	157	24	55	55	CD
cord-007726-bqlf72fe	157	25	]	]	-RRB-
cord-007726-bqlf72fe	157	26	.	.	.
cord-007726-bqlf72fe	158	1	As	as	IN
cord-007726-bqlf72fe	158	2	the	the	DT
cord-007726-bqlf72fe	158	3	reason	reason	NN
cord-007726-bqlf72fe	158	4	behind	behind	IN
cord-007726-bqlf72fe	158	5	this	this	DT
cord-007726-bqlf72fe	158	6	defective	defective	JJ
cord-007726-bqlf72fe	158	7	repair	repair	NN
cord-007726-bqlf72fe	158	8	is	be	VBZ
cord-007726-bqlf72fe	158	9	unknown	unknown	JJ
cord-007726-bqlf72fe	158	10	,	,	,
cord-007726-bqlf72fe	158	11	although	although	IN
cord-007726-bqlf72fe	158	12	a	a	DT
cord-007726-bqlf72fe	158	13	combination	combination	NN
cord-007726-bqlf72fe	158	14	of	of	IN
cord-007726-bqlf72fe	158	15	immunological	immunological	JJ
cord-007726-bqlf72fe	158	16	,	,	,
cord-007726-bqlf72fe	158	17	genetic	genetic	JJ
cord-007726-bqlf72fe	158	18	,	,	,
cord-007726-bqlf72fe	158	19	and	and	CC
cord-007726-bqlf72fe	158	20	environmental	environmental	JJ
cord-007726-bqlf72fe	158	21	factors	factor	NNS
cord-007726-bqlf72fe	158	22	are	be	VBP
cord-007726-bqlf72fe	158	23	suspected	suspect	VBN
cord-007726-bqlf72fe	158	24	,	,	,
cord-007726-bqlf72fe	158	25	it	-PRON-	PRP
cord-007726-bqlf72fe	158	26	is	be	VBZ
cord-007726-bqlf72fe	158	27	very	very	RB
cord-007726-bqlf72fe	158	28	difficult	difficult	JJ
cord-007726-bqlf72fe	158	29	to	to	TO
cord-007726-bqlf72fe	158	30	model	model	VB
cord-007726-bqlf72fe	158	31	disease	disease	NN
cord-007726-bqlf72fe	158	32	in	in	IN
cord-007726-bqlf72fe	158	33	a	a	DT
cord-007726-bqlf72fe	158	34	clinically	clinically	RB
cord-007726-bqlf72fe	158	35	relevant	relevant	JJ
cord-007726-bqlf72fe	158	36	fashion	fashion	NN
cord-007726-bqlf72fe	158	37	[	[	-LRB-
cord-007726-bqlf72fe	158	38	56	56	CD
cord-007726-bqlf72fe	158	39	]	]	-RRB-
cord-007726-bqlf72fe	158	40	.	.	.
cord-007726-bqlf72fe	159	1	The	the	DT
cord-007726-bqlf72fe	159	2	most	most	RBS
cord-007726-bqlf72fe	159	3	common	common	JJ
cord-007726-bqlf72fe	159	4	method	method	NN
cord-007726-bqlf72fe	159	5	used	use	VBN
cord-007726-bqlf72fe	159	6	to	to	TO
cord-007726-bqlf72fe	159	7	model	model	VB
cord-007726-bqlf72fe	159	8	pulmonary	pulmonary	JJ
cord-007726-bqlf72fe	159	9	fibrosis	fibrosis	NN
cord-007726-bqlf72fe	159	10	in	in	IN
cord-007726-bqlf72fe	159	11	mice	mice	NN
cord-007726-bqlf72fe	159	12	is	be	VBZ
cord-007726-bqlf72fe	159	13	administration	administration	NN
cord-007726-bqlf72fe	159	14	of	of	IN
cord-007726-bqlf72fe	159	15	the	the	DT
cord-007726-bqlf72fe	159	16	chemotherapeutic	chemotherapeutic	JJ
cord-007726-bqlf72fe	159	17	agent	agent	NN
cord-007726-bqlf72fe	159	18	bleomycin	bleomycin	NN
cord-007726-bqlf72fe	159	19	;	;	:
cord-007726-bqlf72fe	159	20	this	this	DT
cord-007726-bqlf72fe	159	21	agent	agent	NN
cord-007726-bqlf72fe	159	22	is	be	VBZ
cord-007726-bqlf72fe	159	23	known	know	VBN
cord-007726-bqlf72fe	159	24	to	to	TO
cord-007726-bqlf72fe	159	25	cause	cause	VB
cord-007726-bqlf72fe	159	26	pulmonary	pulmonary	JJ
cord-007726-bqlf72fe	159	27	fibrosis	fibrosis	NN
cord-007726-bqlf72fe	159	28	in	in	IN
cord-007726-bqlf72fe	159	29	humans	human	NNS
cord-007726-bqlf72fe	159	30	as	as	RB
cord-007726-bqlf72fe	159	31	well	well	RB
cord-007726-bqlf72fe	159	32	,	,	,
cord-007726-bqlf72fe	159	33	but	but	CC
cord-007726-bqlf72fe	159	34	this	this	DT
cord-007726-bqlf72fe	159	35	may	may	MD
cord-007726-bqlf72fe	159	36	not	not	RB
cord-007726-bqlf72fe	159	37	accurately	accurately	RB
cord-007726-bqlf72fe	159	38	reflect	reflect	VB
cord-007726-bqlf72fe	159	39	the	the	DT
cord-007726-bqlf72fe	159	40	true	true	JJ
cord-007726-bqlf72fe	159	41	etiology	etiology	NN
cord-007726-bqlf72fe	159	42	of	of	IN
cord-007726-bqlf72fe	159	43	most	most	JJS
cord-007726-bqlf72fe	159	44	cases	case	NNS
cord-007726-bqlf72fe	159	45	of	of	IN
cord-007726-bqlf72fe	159	46	human	human	JJ
cord-007726-bqlf72fe	159	47	disease	disease	NN
cord-007726-bqlf72fe	159	48	.	.	.
cord-007726-bqlf72fe	160	1	The	the	DT
cord-007726-bqlf72fe	160	2	strain	strain	NN
cord-007726-bqlf72fe	160	3	of	of	IN
cord-007726-bqlf72fe	160	4	choice	choice	NN
cord-007726-bqlf72fe	160	5	is	be	VBZ
cord-007726-bqlf72fe	160	6	C57BL/6	C57BL/6	NNP
cord-007726-bqlf72fe	160	7	,	,	,
cord-007726-bqlf72fe	160	8	as	as	IN
cord-007726-bqlf72fe	160	9	it	-PRON-	PRP
cord-007726-bqlf72fe	160	10	is	be	VBZ
cord-007726-bqlf72fe	160	11	prone	prone	JJ
cord-007726-bqlf72fe	160	12	to	to	IN
cord-007726-bqlf72fe	160	13	developing	develop	VBG
cord-007726-bqlf72fe	160	14	pulmonary	pulmonary	JJ
cord-007726-bqlf72fe	160	15	fibrosis	fibrosis	NN
cord-007726-bqlf72fe	160	16	,	,	,
cord-007726-bqlf72fe	160	17	whereas	whereas	IN
cord-007726-bqlf72fe	160	18	BALB	BALB	NNP
cord-007726-bqlf72fe	160	19	/	/	SYM
cord-007726-bqlf72fe	160	20	c	c	NN
cord-007726-bqlf72fe	160	21	is	be	VBZ
cord-007726-bqlf72fe	160	22	relatively	relatively	RB
cord-007726-bqlf72fe	160	23	resistant	resistant	JJ
cord-007726-bqlf72fe	160	24	,	,	,
cord-007726-bqlf72fe	160	25	a	a	DT
cord-007726-bqlf72fe	160	26	feature	feature	NN
cord-007726-bqlf72fe	160	27	believed	believe	VBN
cord-007726-bqlf72fe	160	28	to	to	TO
cord-007726-bqlf72fe	160	29	reflect	reflect	VB
cord-007726-bqlf72fe	160	30	the	the	DT
cord-007726-bqlf72fe	160	31	cytokine	cytokine	NN
cord-007726-bqlf72fe	160	32	response	response	NN
cord-007726-bqlf72fe	160	33	following	follow	VBG
cord-007726-bqlf72fe	160	34	cellular	cellular	JJ
cord-007726-bqlf72fe	160	35	stress	stress	NN
cord-007726-bqlf72fe	160	36	and	and	CC
cord-007726-bqlf72fe	160	37	damage	damage	NN
cord-007726-bqlf72fe	160	38	[	[	-LRB-
cord-007726-bqlf72fe	160	39	57	57	CD
cord-007726-bqlf72fe	160	40	]	]	-RRB-
cord-007726-bqlf72fe	160	41	.	.	.
cord-007726-bqlf72fe	161	1	Bleomycin	Bleomycin	NNP
cord-007726-bqlf72fe	161	2	administration	administration	NN
cord-007726-bqlf72fe	161	3	can	can	MD
cord-007726-bqlf72fe	161	4	be	be	VB
cord-007726-bqlf72fe	161	5	performed	perform	VBN
cord-007726-bqlf72fe	161	6	locally	locally	RB
cord-007726-bqlf72fe	161	7	or	or	CC
cord-007726-bqlf72fe	161	8	systemically	systemically	RB
cord-007726-bqlf72fe	161	9	,	,	,
cord-007726-bqlf72fe	161	10	producing	produce	VBG
cord-007726-bqlf72fe	161	11	very	very	RB
cord-007726-bqlf72fe	161	12	different	different	JJ
cord-007726-bqlf72fe	161	13	results	result	NNS
cord-007726-bqlf72fe	161	14	.	.	.
cord-007726-bqlf72fe	162	1	The	the	DT
cord-007726-bqlf72fe	162	2	most	most	RBS
cord-007726-bqlf72fe	162	3	common	common	JJ
cord-007726-bqlf72fe	162	4	model	model	NN
cord-007726-bqlf72fe	162	5	of	of	IN
cord-007726-bqlf72fe	162	6	pulmonary	pulmonary	JJ
cord-007726-bqlf72fe	162	7	fibrosis	fibrosis	NN
cord-007726-bqlf72fe	162	8	is	be	VBZ
cord-007726-bqlf72fe	162	9	a	a	DT
cord-007726-bqlf72fe	162	10	single	single	JJ
cord-007726-bqlf72fe	162	11	intranasal	intranasal	NN
cord-007726-bqlf72fe	162	12	or	or	CC
cord-007726-bqlf72fe	162	13	intratracheal	intratracheal	NNP
cord-007726-bqlf72fe	162	14	administration	administration	NN
cord-007726-bqlf72fe	162	15	of	of	IN
cord-007726-bqlf72fe	162	16	bleomycin	bleomycin	NNP
cord-007726-bqlf72fe	162	17	,	,	,
cord-007726-bqlf72fe	162	18	with	with	IN
cord-007726-bqlf72fe	162	19	analysis	analysis	NN
cord-007726-bqlf72fe	162	20	3	3	CD
cord-007726-bqlf72fe	162	21	to	to	IN
cord-007726-bqlf72fe	162	22	4	4	CD
cord-007726-bqlf72fe	162	23	weeks	week	NNS
cord-007726-bqlf72fe	162	24	later	later	RB
cord-007726-bqlf72fe	162	25	.	.	.
cord-007726-bqlf72fe	163	1	During	during	IN
cord-007726-bqlf72fe	163	2	this	this	DT
cord-007726-bqlf72fe	163	3	time	time	NN
cord-007726-bqlf72fe	163	4	,	,	,
cord-007726-bqlf72fe	163	5	the	the	DT
cord-007726-bqlf72fe	163	6	drug	drug	NN
cord-007726-bqlf72fe	163	7	causes	cause	VBZ
cord-007726-bqlf72fe	163	8	acute	acute	JJ
cord-007726-bqlf72fe	163	9	tissue	tissue	NN
cord-007726-bqlf72fe	163	10	damage	damage	NN
cord-007726-bqlf72fe	163	11	in	in	IN
cord-007726-bqlf72fe	163	12	a	a	DT
cord-007726-bqlf72fe	163	13	restricted	restricted	JJ
cord-007726-bqlf72fe	163	14	area	area	NN
cord-007726-bqlf72fe	163	15	of	of	IN
cord-007726-bqlf72fe	163	16	the	the	DT
cord-007726-bqlf72fe	163	17	lung	lung	NN
cord-007726-bqlf72fe	163	18	(	(	-LRB-
cord-007726-bqlf72fe	163	19	where	where	WRB
cord-007726-bqlf72fe	163	20	the	the	DT
cord-007726-bqlf72fe	163	21	solution	solution	NN
cord-007726-bqlf72fe	163	22	ends	end	VBZ
cord-007726-bqlf72fe	163	23	up	up	RP
cord-007726-bqlf72fe	163	24	during	during	IN
cord-007726-bqlf72fe	163	25	administration	administration	NN
cord-007726-bqlf72fe	163	26	)	)	-RRB-
cord-007726-bqlf72fe	163	27	,	,	,
cord-007726-bqlf72fe	163	28	followed	follow	VBN
cord-007726-bqlf72fe	163	29	by	by	IN
cord-007726-bqlf72fe	163	30	intense	intense	JJ
cord-007726-bqlf72fe	163	31	inflammation	inflammation	NN
cord-007726-bqlf72fe	163	32	in	in	IN
cord-007726-bqlf72fe	163	33	this	this	DT
cord-007726-bqlf72fe	163	34	area	area	NN
cord-007726-bqlf72fe	163	35	and	and	CC
cord-007726-bqlf72fe	163	36	subsequent	subsequent	JJ
cord-007726-bqlf72fe	163	37	fibrosis	fibrosis	NN
cord-007726-bqlf72fe	163	38	,	,	,
cord-007726-bqlf72fe	163	39	which	which	WDT
cord-007726-bqlf72fe	163	40	gradually	gradually	RB
cord-007726-bqlf72fe	163	41	resolves	resolve	VBZ
cord-007726-bqlf72fe	163	42	within	within	IN
cord-007726-bqlf72fe	163	43	weeks	week	NNS
cord-007726-bqlf72fe	163	44	.	.	.
cord-007726-bqlf72fe	164	1	However	however	RB
cord-007726-bqlf72fe	164	2	,	,	,
cord-007726-bqlf72fe	164	3	if	if	IN
cord-007726-bqlf72fe	164	4	older	old	JJR
cord-007726-bqlf72fe	164	5	mice	mouse	NNS
cord-007726-bqlf72fe	164	6	are	be	VBP
cord-007726-bqlf72fe	164	7	used	use	VBN
cord-007726-bqlf72fe	164	8	,	,	,
cord-007726-bqlf72fe	164	9	the	the	DT
cord-007726-bqlf72fe	164	10	fibrosis	fibrosis	NN
cord-007726-bqlf72fe	164	11	will	will	MD
cord-007726-bqlf72fe	164	12	persist	persist	VB
cord-007726-bqlf72fe	164	13	longer	long	RBR
cord-007726-bqlf72fe	164	14	than	than	IN
cord-007726-bqlf72fe	164	15	in	in	IN
cord-007726-bqlf72fe	164	16	younger	young	JJR
cord-007726-bqlf72fe	164	17	mice	mouse	NNS
cord-007726-bqlf72fe	164	18	,	,	,
cord-007726-bqlf72fe	164	19	which	which	WDT
cord-007726-bqlf72fe	164	20	is	be	VBZ
cord-007726-bqlf72fe	164	21	in	in	IN
cord-007726-bqlf72fe	164	22	accordance	accordance	NN
cord-007726-bqlf72fe	164	23	with	with	IN
cord-007726-bqlf72fe	164	24	clinical	clinical	JJ
cord-007726-bqlf72fe	164	25	IPF	IPF	NNP
cord-007726-bqlf72fe	164	26	,	,	,
cord-007726-bqlf72fe	164	27	where	where	WRB
cord-007726-bqlf72fe	164	28	the	the	DT
cord-007726-bqlf72fe	164	29	majority	majority	NN
cord-007726-bqlf72fe	164	30	of	of	IN
cord-007726-bqlf72fe	164	31	the	the	DT
cord-007726-bqlf72fe	164	32	patients	patient	NNS
cord-007726-bqlf72fe	164	33	are	be	VBP
cord-007726-bqlf72fe	164	34	65	65	CD
cord-007726-bqlf72fe	164	35	years	year	NNS
cord-007726-bqlf72fe	164	36	of	of	IN
cord-007726-bqlf72fe	164	37	age	age	NN
cord-007726-bqlf72fe	164	38	or	or	CC
cord-007726-bqlf72fe	164	39	older	old	JJR
cord-007726-bqlf72fe	164	40	[	[	-LRB-
cord-007726-bqlf72fe	164	41	56	56	CD
cord-007726-bqlf72fe	164	42	,	,	,
cord-007726-bqlf72fe	164	43	58	58	CD
cord-007726-bqlf72fe	164	44	]	]	-RRB-
cord-007726-bqlf72fe	164	45	.	.	.
cord-007726-bqlf72fe	165	1	A	a	DT
cord-007726-bqlf72fe	165	2	great	great	JJ
cord-007726-bqlf72fe	165	3	advantage	advantage	NN
cord-007726-bqlf72fe	165	4	of	of	IN
cord-007726-bqlf72fe	165	5	this	this	DT
cord-007726-bqlf72fe	165	6	model	model	NN
cord-007726-bqlf72fe	165	7	is	be	VBZ
cord-007726-bqlf72fe	165	8	how	how	WRB
cord-007726-bqlf72fe	165	9	well	well	RB
cord-007726-bqlf72fe	165	10	-	-	HYPH
cord-007726-bqlf72fe	165	11	characterized	characterize	VBN
cord-007726-bqlf72fe	165	12	it	-PRON-	PRP
cord-007726-bqlf72fe	165	13	is	be	VBZ
cord-007726-bqlf72fe	165	14	.	.	.
cord-007726-bqlf72fe	166	1	In	in	IN
cord-007726-bqlf72fe	166	2	addition	addition	NN
cord-007726-bqlf72fe	166	3	,	,	,
cord-007726-bqlf72fe	166	4	local	local	JJ
cord-007726-bqlf72fe	166	5	administration	administration	NN
cord-007726-bqlf72fe	166	6	is	be	VBZ
cord-007726-bqlf72fe	166	7	labor	labor	NN
cord-007726-bqlf72fe	166	8	-	-	HYPH
cord-007726-bqlf72fe	166	9	effective	effective	JJ
cord-007726-bqlf72fe	166	10	,	,	,
cord-007726-bqlf72fe	166	11	as	as	IN
cord-007726-bqlf72fe	166	12	only	only	RB
cord-007726-bqlf72fe	166	13	one	one	CD
cord-007726-bqlf72fe	166	14	administration	administration	NN
cord-007726-bqlf72fe	166	15	is	be	VBZ
cord-007726-bqlf72fe	166	16	required	require	VBN
cord-007726-bqlf72fe	166	17	and	and	CC
cord-007726-bqlf72fe	166	18	the	the	DT
cord-007726-bqlf72fe	166	19	result	result	NN
cord-007726-bqlf72fe	166	20	is	be	VBZ
cord-007726-bqlf72fe	166	21	highly	highly	RB
cord-007726-bqlf72fe	166	22	reproducible	reproducible	JJ
cord-007726-bqlf72fe	166	23	.	.	.
cord-007726-bqlf72fe	167	1	The	the	DT
cord-007726-bqlf72fe	167	2	fibrosis	fibrosis	NN
cord-007726-bqlf72fe	167	3	is	be	VBZ
cord-007726-bqlf72fe	167	4	robust	robust	JJ
cord-007726-bqlf72fe	167	5	,	,	,
cord-007726-bqlf72fe	167	6	only	only	RB
cord-007726-bqlf72fe	167	7	affects	affect	VBZ
cord-007726-bqlf72fe	167	8	the	the	DT
cord-007726-bqlf72fe	167	9	lungs	lung	NNS
cord-007726-bqlf72fe	167	10	,	,	,
cord-007726-bqlf72fe	167	11	and	and	CC
cord-007726-bqlf72fe	167	12	the	the	DT
cord-007726-bqlf72fe	167	13	accumulation	accumulation	NN
cord-007726-bqlf72fe	167	14	of	of	IN
cord-007726-bqlf72fe	167	15	extracellular	extracellular	JJ
cord-007726-bqlf72fe	167	16	matrix	matrix	NN
cord-007726-bqlf72fe	167	17	can	can	MD
cord-007726-bqlf72fe	167	18	be	be	VB
cord-007726-bqlf72fe	167	19	easily	easily	RB
cord-007726-bqlf72fe	167	20	measured	measure	VBN
cord-007726-bqlf72fe	167	21	using	use	VBG
cord-007726-bqlf72fe	167	22	standard	standard	JJ
cord-007726-bqlf72fe	167	23	techniques	technique	NNS
cord-007726-bqlf72fe	167	24	[	[	-LRB-
cord-007726-bqlf72fe	167	25	58	58	CD
cord-007726-bqlf72fe	167	26	]	]	-RRB-
cord-007726-bqlf72fe	167	27	.	.	.
cord-007726-bqlf72fe	168	1	Furthermore	furthermore	RB
cord-007726-bqlf72fe	168	2	,	,	,
cord-007726-bqlf72fe	168	3	as	as	IN
cord-007726-bqlf72fe	168	4	it	-PRON-	PRP
cord-007726-bqlf72fe	168	5	is	be	VBZ
cord-007726-bqlf72fe	168	6	used	use	VBN
cord-007726-bqlf72fe	168	7	throughout	throughout	IN
cord-007726-bqlf72fe	168	8	the	the	DT
cord-007726-bqlf72fe	168	9	world	world	NN
cord-007726-bqlf72fe	168	10	,	,	,
cord-007726-bqlf72fe	168	11	studies	study	NNS
cord-007726-bqlf72fe	168	12	performed	perform	VBN
cord-007726-bqlf72fe	168	13	in	in	IN
cord-007726-bqlf72fe	168	14	different	different	JJ
cord-007726-bqlf72fe	168	15	labs	lab	NNS
cord-007726-bqlf72fe	168	16	and	and	CC
cord-007726-bqlf72fe	168	17	by	by	IN
cord-007726-bqlf72fe	168	18	different	different	JJ
cord-007726-bqlf72fe	168	19	groups	group	NNS
cord-007726-bqlf72fe	168	20	can	can	MD
cord-007726-bqlf72fe	168	21	be	be	VB
cord-007726-bqlf72fe	168	22	compared	compare	VBN
cord-007726-bqlf72fe	168	23	relatively	relatively	RB
cord-007726-bqlf72fe	168	24	easily	easily	RB
cord-007726-bqlf72fe	168	25	.	.	.
cord-007726-bqlf72fe	169	1	Unfortunately	unfortunately	RB
cord-007726-bqlf72fe	169	2	,	,	,
cord-007726-bqlf72fe	169	3	the	the	DT
cord-007726-bqlf72fe	169	4	intense	intense	JJ
cord-007726-bqlf72fe	169	5	pulmonary	pulmonary	JJ
cord-007726-bqlf72fe	169	6	inflammation	inflammation	NN
cord-007726-bqlf72fe	169	7	may	may	MD
cord-007726-bqlf72fe	169	8	be	be	VB
cord-007726-bqlf72fe	169	9	lethal	lethal	JJ
cord-007726-bqlf72fe	169	10	,	,	,
cord-007726-bqlf72fe	169	11	and	and	CC
cord-007726-bqlf72fe	169	12	fatalities	fatality	NNS
cord-007726-bqlf72fe	169	13	are	be	VBP
cord-007726-bqlf72fe	169	14	to	to	TO
cord-007726-bqlf72fe	169	15	be	be	VB
cord-007726-bqlf72fe	169	16	expected	expect	VBN
cord-007726-bqlf72fe	169	17	with	with	IN
cord-007726-bqlf72fe	169	18	this	this	DT
cord-007726-bqlf72fe	169	19	model	model	NN
cord-007726-bqlf72fe	169	20	[	[	-LRB-
cord-007726-bqlf72fe	169	21	59	59	CD
cord-007726-bqlf72fe	169	22	]	]	-RRB-
cord-007726-bqlf72fe	169	23	,	,	,
cord-007726-bqlf72fe	169	24	representing	represent	VBG
cord-007726-bqlf72fe	169	25	an	an	DT
cord-007726-bqlf72fe	169	26	important	important	JJ
cord-007726-bqlf72fe	169	27	ethical	ethical	JJ
cord-007726-bqlf72fe	169	28	limitation	limitation	NN
cord-007726-bqlf72fe	169	29	.	.	.
cord-007726-bqlf72fe	170	1	Furthermore	furthermore	RB
cord-007726-bqlf72fe	170	2	,	,	,
cord-007726-bqlf72fe	170	3	fibrosis	fibrosis	NN
cord-007726-bqlf72fe	170	4	is	be	VBZ
cord-007726-bqlf72fe	170	5	heterogeneous	heterogeneous	JJ
cord-007726-bqlf72fe	170	6	-	-	:
cord-007726-bqlf72fe	170	7	it	-PRON-	PRP
cord-007726-bqlf72fe	170	8	develops	develop	VBZ
cord-007726-bqlf72fe	170	9	where	where	WRB
cord-007726-bqlf72fe	170	10	the	the	DT
cord-007726-bqlf72fe	170	11	bleomycin	bleomycin	NN
cord-007726-bqlf72fe	170	12	solution	solution	NN
cord-007726-bqlf72fe	170	13	is	be	VBZ
cord-007726-bqlf72fe	170	14	deposited	deposit	VBN
cord-007726-bqlf72fe	170	15	.	.	.
cord-007726-bqlf72fe	171	1	The	the	DT
cord-007726-bqlf72fe	171	2	solution	solution	NN
cord-007726-bqlf72fe	171	3	usually	usually	RB
cord-007726-bqlf72fe	171	4	deposits	deposit	VBZ
cord-007726-bqlf72fe	171	5	within	within	IN
cord-007726-bqlf72fe	171	6	the	the	DT
cord-007726-bqlf72fe	171	7	central	central	JJ
cord-007726-bqlf72fe	171	8	lung	lung	NN
cord-007726-bqlf72fe	171	9	,	,	,
cord-007726-bqlf72fe	171	10	a	a	DT
cord-007726-bqlf72fe	171	11	localization	localization	NN
cord-007726-bqlf72fe	171	12	that	that	WDT
cord-007726-bqlf72fe	171	13	is	be	VBZ
cord-007726-bqlf72fe	171	14	not	not	RB
cord-007726-bqlf72fe	171	15	in	in	IN
cord-007726-bqlf72fe	171	16	agreement	agreement	NN
cord-007726-bqlf72fe	171	17	with	with	IN
cord-007726-bqlf72fe	171	18	the	the	DT
cord-007726-bqlf72fe	171	19	clinical	clinical	JJ
cord-007726-bqlf72fe	171	20	situation	situation	NN
cord-007726-bqlf72fe	171	21	where	where	WRB
cord-007726-bqlf72fe	171	22	fibrosis	fibrosis	NN
cord-007726-bqlf72fe	171	23	is	be	VBZ
cord-007726-bqlf72fe	171	24	located	locate	VBN
cord-007726-bqlf72fe	171	25	in	in	IN
cord-007726-bqlf72fe	171	26	the	the	DT
cord-007726-bqlf72fe	171	27	more	more	RBR
cord-007726-bqlf72fe	171	28	distal	distal	JJ
cord-007726-bqlf72fe	171	29	regions	region	NNS
cord-007726-bqlf72fe	171	30	of	of	IN
cord-007726-bqlf72fe	171	31	the	the	DT
cord-007726-bqlf72fe	171	32	lung	lung	NN
cord-007726-bqlf72fe	171	33	parenchyma	parenchyma	NN
cord-007726-bqlf72fe	171	34	.	.	.
cord-007726-bqlf72fe	172	1	In	in	IN
cord-007726-bqlf72fe	172	2	addition	addition	NN
cord-007726-bqlf72fe	172	3	,	,	,
cord-007726-bqlf72fe	172	4	the	the	DT
cord-007726-bqlf72fe	172	5	fibrosis	fibrosis	NN
cord-007726-bqlf72fe	172	6	that	that	WDT
cord-007726-bqlf72fe	172	7	develops	develop	VBZ
cord-007726-bqlf72fe	172	8	as	as	IN
cord-007726-bqlf72fe	172	9	a	a	DT
cord-007726-bqlf72fe	172	10	result	result	NN
cord-007726-bqlf72fe	172	11	of	of	IN
cord-007726-bqlf72fe	172	12	severe	severe	JJ
cord-007726-bqlf72fe	172	13	tissue	tissue	NN
cord-007726-bqlf72fe	172	14	damage	damage	NN
cord-007726-bqlf72fe	172	15	is	be	VBZ
cord-007726-bqlf72fe	172	16	self	self	NN
cord-007726-bqlf72fe	172	17	-	-	HYPH
cord-007726-bqlf72fe	172	18	limiting	limit	VBG
cord-007726-bqlf72fe	172	19	and	and	CC
cord-007726-bqlf72fe	172	20	reversible	reversible	JJ
cord-007726-bqlf72fe	172	21	,	,	,
cord-007726-bqlf72fe	172	22	unlike	unlike	IN
cord-007726-bqlf72fe	172	23	what	what	WP
cord-007726-bqlf72fe	172	24	is	be	VBZ
cord-007726-bqlf72fe	172	25	observed	observe	VBN
cord-007726-bqlf72fe	172	26	clinically	clinically	RB
cord-007726-bqlf72fe	172	27	[	[	-LRB-
cord-007726-bqlf72fe	172	28	58	58	CD
cord-007726-bqlf72fe	172	29	]	]	-RRB-
cord-007726-bqlf72fe	172	30	.	.	.
cord-007726-bqlf72fe	173	1	The	the	DT
cord-007726-bqlf72fe	173	2	severe	severe	JJ
cord-007726-bqlf72fe	173	3	degree	degree	NN
cord-007726-bqlf72fe	173	4	of	of	IN
cord-007726-bqlf72fe	173	5	tissue	tissue	NN
cord-007726-bqlf72fe	173	6	damage	damage	NN
cord-007726-bqlf72fe	173	7	induced	induce	VBN
cord-007726-bqlf72fe	173	8	by	by	IN
cord-007726-bqlf72fe	173	9	bleomycin	bleomycin	NNS
cord-007726-bqlf72fe	173	10	may	may	MD
cord-007726-bqlf72fe	173	11	in	in	IN
cord-007726-bqlf72fe	173	12	fact	fact	NN
cord-007726-bqlf72fe	173	13	be	be	VB
cord-007726-bqlf72fe	173	14	more	more	RBR
cord-007726-bqlf72fe	173	15	relevant	relevant	JJ
cord-007726-bqlf72fe	173	16	for	for	IN
cord-007726-bqlf72fe	173	17	modeling	model	VBG
cord-007726-bqlf72fe	173	18	acute	acute	JJ
cord-007726-bqlf72fe	173	19	lung	lung	NN
cord-007726-bqlf72fe	173	20	injury	injury	NN
cord-007726-bqlf72fe	173	21	(	(	-LRB-
cord-007726-bqlf72fe	173	22	ALI	ALI	NNP
cord-007726-bqlf72fe	173	23	)	)	-RRB-
cord-007726-bqlf72fe	173	24	or	or	CC
cord-007726-bqlf72fe	173	25	acute	acute	JJ
cord-007726-bqlf72fe	173	26	respiratory	respiratory	JJ
cord-007726-bqlf72fe	173	27	distress	distress	NN
cord-007726-bqlf72fe	173	28	syndrome	syndrome	NN
cord-007726-bqlf72fe	173	29	(	(	-LRB-
cord-007726-bqlf72fe	173	30	ARDS	ARDS	NNP
cord-007726-bqlf72fe	173	31	)	)	-RRB-
cord-007726-bqlf72fe	173	32	.	.	.
cord-007726-bqlf72fe	174	1	Bleomycin	Bleomycin	NNP
cord-007726-bqlf72fe	174	2	can	can	MD
cord-007726-bqlf72fe	174	3	also	also	RB
cord-007726-bqlf72fe	174	4	be	be	VB
cord-007726-bqlf72fe	174	5	administered	administer	VBN
cord-007726-bqlf72fe	174	6	systemically	systemically	RB
cord-007726-bqlf72fe	174	7	,	,	,
cord-007726-bqlf72fe	174	8	through	through	IN
cord-007726-bqlf72fe	174	9	intravenous	intravenous	JJ
cord-007726-bqlf72fe	174	10	or	or	CC
cord-007726-bqlf72fe	174	11	subcutaneous	subcutaneous	JJ
cord-007726-bqlf72fe	174	12	injection	injection	NN
cord-007726-bqlf72fe	174	13	.	.	.
cord-007726-bqlf72fe	175	1	In	in	IN
cord-007726-bqlf72fe	175	2	contrast	contrast	NN
cord-007726-bqlf72fe	175	3	to	to	IN
cord-007726-bqlf72fe	175	4	local	local	JJ
cord-007726-bqlf72fe	175	5	administration	administration	NN
cord-007726-bqlf72fe	175	6	,	,	,
cord-007726-bqlf72fe	175	7	this	this	DT
cord-007726-bqlf72fe	175	8	route	route	NN
cord-007726-bqlf72fe	175	9	requires	require	VBZ
cord-007726-bqlf72fe	175	10	multiple	multiple	JJ
cord-007726-bqlf72fe	175	11	administrations	administration	NNS
cord-007726-bqlf72fe	175	12	and	and	CC
cord-007726-bqlf72fe	175	13	is	be	VBZ
cord-007726-bqlf72fe	175	14	thus	thus	RB
cord-007726-bqlf72fe	175	15	more	more	JJR
cord-007726-bqlf72fe	175	16	laborintensive	laborintensive	JJ
cord-007726-bqlf72fe	175	17	[	[	-LRB-
cord-007726-bqlf72fe	175	18	58	58	CD
cord-007726-bqlf72fe	175	19	]	]	-RRB-
cord-007726-bqlf72fe	175	20	.	.	.
cord-007726-bqlf72fe	176	1	Some	some	DT
cord-007726-bqlf72fe	176	2	studies	study	NNS
cord-007726-bqlf72fe	176	3	have	have	VBP
cord-007726-bqlf72fe	176	4	described	describe	VBN
cord-007726-bqlf72fe	176	5	the	the	DT
cord-007726-bqlf72fe	176	6	usage	usage	NN
cord-007726-bqlf72fe	176	7	of	of	IN
cord-007726-bqlf72fe	176	8	osmotic	osmotic	JJ
cord-007726-bqlf72fe	176	9	mini	mini	NN
cord-007726-bqlf72fe	176	10	-	-	NNS
cord-007726-bqlf72fe	176	11	pumps	pump	NNS
cord-007726-bqlf72fe	176	12	,	,	,
cord-007726-bqlf72fe	176	13	where	where	WRB
cord-007726-bqlf72fe	176	14	bleomycin	bleomycin	NN
cord-007726-bqlf72fe	176	15	is	be	VBZ
cord-007726-bqlf72fe	176	16	slowly	slowly	RB
cord-007726-bqlf72fe	176	17	administered	administer	VBN
cord-007726-bqlf72fe	176	18	over	over	IN
cord-007726-bqlf72fe	176	19	a	a	DT
cord-007726-bqlf72fe	176	20	short	short	JJ
cord-007726-bqlf72fe	176	21	period	period	NN
cord-007726-bqlf72fe	176	22	of	of	IN
cord-007726-bqlf72fe	176	23	time	time	NN
cord-007726-bqlf72fe	176	24	,	,	,
cord-007726-bqlf72fe	176	25	and	and	CC
cord-007726-bqlf72fe	176	26	then	then	RB
cord-007726-bqlf72fe	176	27	fibrosis	fibrosis	NN
cord-007726-bqlf72fe	176	28	continues	continue	VBZ
cord-007726-bqlf72fe	176	29	to	to	TO
cord-007726-bqlf72fe	176	30	develop	develop	VB
cord-007726-bqlf72fe	176	31	over	over	IN
cord-007726-bqlf72fe	176	32	subsequent	subsequent	JJ
cord-007726-bqlf72fe	176	33	weeks	week	NNS
cord-007726-bqlf72fe	176	34	[	[	-LRB-
cord-007726-bqlf72fe	176	35	60	60	CD
cord-007726-bqlf72fe	176	36	]	]	-RRB-
cord-007726-bqlf72fe	176	37	.	.	.
cord-007726-bqlf72fe	177	1	Irrespective	irrespective	RB
cord-007726-bqlf72fe	177	2	of	of	IN
cord-007726-bqlf72fe	177	3	the	the	DT
cord-007726-bqlf72fe	177	4	route	route	NN
cord-007726-bqlf72fe	177	5	of	of	IN
cord-007726-bqlf72fe	177	6	delivery	delivery	NN
cord-007726-bqlf72fe	177	7	,	,	,
cord-007726-bqlf72fe	177	8	systemic	systemic	JJ
cord-007726-bqlf72fe	177	9	administration	administration	NN
cord-007726-bqlf72fe	177	10	results	result	VBZ
cord-007726-bqlf72fe	177	11	in	in	IN
cord-007726-bqlf72fe	177	12	more	more	RBR
cord-007726-bqlf72fe	177	13	homogenous	homogenous	JJ
cord-007726-bqlf72fe	177	14	fibrosis	fibrosis	NN
cord-007726-bqlf72fe	177	15	,	,	,
cord-007726-bqlf72fe	177	16	affecting	affect	VBG
cord-007726-bqlf72fe	177	17	the	the	DT
cord-007726-bqlf72fe	177	18	entire	entire	JJ
cord-007726-bqlf72fe	177	19	lung	lung	NN
cord-007726-bqlf72fe	177	20	through	through	IN
cord-007726-bqlf72fe	177	21	the	the	DT
cord-007726-bqlf72fe	177	22	pulmonary	pulmonary	JJ
cord-007726-bqlf72fe	177	23	endothelium	endothelium	NN
cord-007726-bqlf72fe	177	24	and	and	CC
cord-007726-bqlf72fe	177	25	persisting	persist	VBG
cord-007726-bqlf72fe	177	26	much	much	RB
cord-007726-bqlf72fe	177	27	longer	long	RBR
cord-007726-bqlf72fe	177	28	than	than	IN
cord-007726-bqlf72fe	177	29	following	follow	VBG
cord-007726-bqlf72fe	177	30	local	local	JJ
cord-007726-bqlf72fe	177	31	administration	administration	NN
cord-007726-bqlf72fe	177	32	[	[	-LRB-
cord-007726-bqlf72fe	177	33	61	61	CD
cord-007726-bqlf72fe	177	34	]	]	-RRB-
cord-007726-bqlf72fe	177	35	.	.	.
cord-007726-bqlf72fe	178	1	The	the	DT
cord-007726-bqlf72fe	178	2	main	main	JJ
cord-007726-bqlf72fe	178	3	advantages	advantage	NNS
cord-007726-bqlf72fe	178	4	of	of	IN
cord-007726-bqlf72fe	178	5	systemic	systemic	JJ
cord-007726-bqlf72fe	178	6	administration	administration	NN
cord-007726-bqlf72fe	178	7	are	be	VBP
cord-007726-bqlf72fe	178	8	that	that	IN
cord-007726-bqlf72fe	178	9	inflammation	inflammation	NN
cord-007726-bqlf72fe	178	10	is	be	VBZ
cord-007726-bqlf72fe	178	11	limited	limit	VBN
cord-007726-bqlf72fe	178	12	,	,	,
cord-007726-bqlf72fe	178	13	while	while	IN
cord-007726-bqlf72fe	178	14	the	the	DT
cord-007726-bqlf72fe	178	15	fibrosis	fibrosis	NN
cord-007726-bqlf72fe	178	16	is	be	VBZ
cord-007726-bqlf72fe	178	17	more	more	RBR
cord-007726-bqlf72fe	178	18	apparent	apparent	JJ
cord-007726-bqlf72fe	178	19	and	and	CC
cord-007726-bqlf72fe	178	20	displays	display	VBZ
cord-007726-bqlf72fe	178	21	a	a	DT
cord-007726-bqlf72fe	178	22	more	more	RBR
cord-007726-bqlf72fe	178	23	distal	distal	JJ
cord-007726-bqlf72fe	178	24	pattern	pattern	NN
cord-007726-bqlf72fe	178	25	,	,	,
cord-007726-bqlf72fe	178	26	all	all	DT
cord-007726-bqlf72fe	178	27	of	of	IN
cord-007726-bqlf72fe	178	28	which	which	WDT
cord-007726-bqlf72fe	178	29	mimics	mimic	VBZ
cord-007726-bqlf72fe	178	30	the	the	DT
cord-007726-bqlf72fe	178	31	clinical	clinical	JJ
cord-007726-bqlf72fe	178	32	situation	situation	NN
cord-007726-bqlf72fe	178	33	relatively	relatively	RB
cord-007726-bqlf72fe	178	34	well	well	RB
cord-007726-bqlf72fe	178	35	.	.	.
cord-007726-bqlf72fe	179	1	The	the	DT
cord-007726-bqlf72fe	179	2	multiple	multiple	JJ
cord-007726-bqlf72fe	179	3	administrations	administration	NNS
cord-007726-bqlf72fe	179	4	allow	allow	VBP
cord-007726-bqlf72fe	179	5	for	for	IN
cord-007726-bqlf72fe	179	6	lower	low	JJR
cord-007726-bqlf72fe	179	7	doses	dose	NNS
cord-007726-bqlf72fe	179	8	with	with	IN
cord-007726-bqlf72fe	179	9	each	each	DT
cord-007726-bqlf72fe	179	10	injection	injection	NN
cord-007726-bqlf72fe	179	11	;	;	:
cord-007726-bqlf72fe	179	12	this	this	DT
cord-007726-bqlf72fe	179	13	is	be	VBZ
cord-007726-bqlf72fe	179	14	less	less	RBR
cord-007726-bqlf72fe	179	15	stressful	stressful	JJ
cord-007726-bqlf72fe	179	16	to	to	IN
cord-007726-bqlf72fe	179	17	the	the	DT
cord-007726-bqlf72fe	179	18	animals	animal	NNS
cord-007726-bqlf72fe	179	19	and	and	CC
cord-007726-bqlf72fe	179	20	results	result	NNS
cord-007726-bqlf72fe	179	21	in	in	IN
cord-007726-bqlf72fe	179	22	little	little	JJ
cord-007726-bqlf72fe	179	23	to	to	IN
cord-007726-bqlf72fe	179	24	no	no	DT
cord-007726-bqlf72fe	179	25	mortality	mortality	NN
cord-007726-bqlf72fe	179	26	[	[	-LRB-
cord-007726-bqlf72fe	179	27	61	61	CD
cord-007726-bqlf72fe	179	28	]	]	-RRB-
cord-007726-bqlf72fe	179	29	and	and	CC
cord-007726-bqlf72fe	179	30	is	be	VBZ
cord-007726-bqlf72fe	179	31	thus	thus	RB
cord-007726-bqlf72fe	179	32	more	more	RBR
cord-007726-bqlf72fe	179	33	ethically	ethically	RB
cord-007726-bqlf72fe	179	34	acceptable	acceptable	JJ
cord-007726-bqlf72fe	179	35	.	.	.
cord-007726-bqlf72fe	180	1	A	a	DT
cord-007726-bqlf72fe	180	2	major	major	JJ
cord-007726-bqlf72fe	180	3	disadvantage	disadvantage	NN
cord-007726-bqlf72fe	180	4	with	with	IN
cord-007726-bqlf72fe	180	5	this	this	DT
cord-007726-bqlf72fe	180	6	model	model	NN
cord-007726-bqlf72fe	180	7	is	be	VBZ
cord-007726-bqlf72fe	180	8	that	that	IN
cord-007726-bqlf72fe	180	9	it	-PRON-	PRP
cord-007726-bqlf72fe	180	10	takes	take	VBZ
cord-007726-bqlf72fe	180	11	time	time	NN
cord-007726-bqlf72fe	180	12	for	for	IN
cord-007726-bqlf72fe	180	13	fibrosis	fibrosis	NN
cord-007726-bqlf72fe	180	14	to	to	TO
cord-007726-bqlf72fe	180	15	develop	develop	VB
cord-007726-bqlf72fe	180	16	[	[	-LRB-
cord-007726-bqlf72fe	180	17	58	58	CD
cord-007726-bqlf72fe	180	18	]	]	-RRB-
cord-007726-bqlf72fe	180	19	,	,	,
cord-007726-bqlf72fe	180	20	which	which	WDT
cord-007726-bqlf72fe	180	21	may	may	MD
cord-007726-bqlf72fe	180	22	be	be	VB
cord-007726-bqlf72fe	180	23	the	the	DT
cord-007726-bqlf72fe	180	24	reason	reason	NN
cord-007726-bqlf72fe	180	25	it	-PRON-	PRP
cord-007726-bqlf72fe	180	26	is	be	VBZ
cord-007726-bqlf72fe	180	27	used	use	VBN
cord-007726-bqlf72fe	180	28	relatively	relatively	RB
cord-007726-bqlf72fe	180	29	scarcely	scarcely	RB
cord-007726-bqlf72fe	180	30	,	,	,
cord-007726-bqlf72fe	180	31	and	and	CC
cord-007726-bqlf72fe	180	32	thus	thus	RB
cord-007726-bqlf72fe	180	33	the	the	DT
cord-007726-bqlf72fe	180	34	pathological	pathological	JJ
cord-007726-bqlf72fe	180	35	development	development	NN
cord-007726-bqlf72fe	180	36	is	be	VBZ
cord-007726-bqlf72fe	180	37	less	less	RBR
cord-007726-bqlf72fe	180	38	well	well	RB
cord-007726-bqlf72fe	180	39	-	-	HYPH
cord-007726-bqlf72fe	180	40	understood	understand	VBN
cord-007726-bqlf72fe	180	41	.	.	.
cord-007726-bqlf72fe	181	1	In	in	IN
cord-007726-bqlf72fe	181	2	addition	addition	NN
cord-007726-bqlf72fe	181	3	,	,	,
cord-007726-bqlf72fe	181	4	as	as	IN
cord-007726-bqlf72fe	181	5	IPF	IPF	NNP
cord-007726-bqlf72fe	181	6	is	be	VBZ
cord-007726-bqlf72fe	181	7	a	a	DT
cord-007726-bqlf72fe	181	8	local	local	JJ
cord-007726-bqlf72fe	181	9	disease	disease	NN
cord-007726-bqlf72fe	181	10	,	,	,
cord-007726-bqlf72fe	181	11	local	local	JJ
cord-007726-bqlf72fe	181	12	administration	administration	NN
cord-007726-bqlf72fe	181	13	of	of	IN
cord-007726-bqlf72fe	181	14	the	the	DT
cord-007726-bqlf72fe	181	15	etiologic	etiologic	NNP
cord-007726-bqlf72fe	181	16	agent	agent	NN
cord-007726-bqlf72fe	181	17	may	may	MD
cord-007726-bqlf72fe	181	18	better	well	RBR
cord-007726-bqlf72fe	181	19	mimic	mimic	VB
cord-007726-bqlf72fe	181	20	the	the	DT
cord-007726-bqlf72fe	181	21	clinical	clinical	JJ
cord-007726-bqlf72fe	181	22	reality	reality	NN
cord-007726-bqlf72fe	181	23	[	[	-LRB-
cord-007726-bqlf72fe	181	24	56	56	CD
cord-007726-bqlf72fe	181	25	]	]	-RRB-
cord-007726-bqlf72fe	181	26	.	.	.
cord-007726-bqlf72fe	182	1	The	the	DT
cord-007726-bqlf72fe	182	2	administration	administration	NN
cord-007726-bqlf72fe	182	3	of	of	IN
cord-007726-bqlf72fe	182	4	fluorescein	fluorescein	NNP
cord-007726-bqlf72fe	182	5	isothiocyanate	isothiocyanate	NNP
cord-007726-bqlf72fe	182	6	(	(	-LRB-
cord-007726-bqlf72fe	182	7	FITC	FITC	NNP
cord-007726-bqlf72fe	182	8	)	)	-RRB-
cord-007726-bqlf72fe	182	9	induces	induce	VBZ
cord-007726-bqlf72fe	182	10	focal	focal	JJ
cord-007726-bqlf72fe	182	11	inflammation	inflammation	NN
cord-007726-bqlf72fe	182	12	,	,	,
cord-007726-bqlf72fe	182	13	primarily	primarily	RB
cord-007726-bqlf72fe	182	14	involving	involve	VBG
cord-007726-bqlf72fe	182	15	mononuclear	mononuclear	JJ
cord-007726-bqlf72fe	182	16	cells	cell	NNS
cord-007726-bqlf72fe	182	17	and	and	CC
cord-007726-bqlf72fe	182	18	neutrophils	neutrophil	NNS
cord-007726-bqlf72fe	182	19	,	,	,
cord-007726-bqlf72fe	182	20	and	and	CC
cord-007726-bqlf72fe	182	21	localizes	localize	VBZ
cord-007726-bqlf72fe	182	22	in	in	IN
cord-007726-bqlf72fe	182	23	areas	area	NNS
cord-007726-bqlf72fe	182	24	where	where	WRB
cord-007726-bqlf72fe	182	25	the	the	DT
cord-007726-bqlf72fe	182	26	FITC	FITC	NNP
cord-007726-bqlf72fe	182	27	solution	solution	NN
cord-007726-bqlf72fe	182	28	is	be	VBZ
cord-007726-bqlf72fe	182	29	deposited	deposit	VBN
cord-007726-bqlf72fe	182	30	[	[	-LRB-
cord-007726-bqlf72fe	182	31	58	58	CD
cord-007726-bqlf72fe	182	32	]	]	-RRB-
cord-007726-bqlf72fe	182	33	.	.	.
cord-007726-bqlf72fe	183	1	Antibodies	antibody	NNS
cord-007726-bqlf72fe	183	2	against	against	IN
cord-007726-bqlf72fe	183	3	FITC	FITC	NNP
cord-007726-bqlf72fe	183	4	can	can	MD
cord-007726-bqlf72fe	183	5	be	be	VB
cord-007726-bqlf72fe	183	6	detected	detect	VBN
cord-007726-bqlf72fe	183	7	after	after	IN
cord-007726-bqlf72fe	183	8	1	1	CD
cord-007726-bqlf72fe	183	9	week	week	NN
cord-007726-bqlf72fe	183	10	,	,	,
cord-007726-bqlf72fe	183	11	and	and	CC
cord-007726-bqlf72fe	183	12	the	the	DT
cord-007726-bqlf72fe	183	13	fibrosis	fibrosis	NN
cord-007726-bqlf72fe	183	14	persists	persist	VBZ
cord-007726-bqlf72fe	183	15	for	for	IN
cord-007726-bqlf72fe	183	16	up	up	IN
cord-007726-bqlf72fe	183	17	to	to	TO
cord-007726-bqlf72fe	183	18	5	5	CD
cord-007726-bqlf72fe	183	19	months	month	NNS
cord-007726-bqlf72fe	183	20	after	after	IN
cord-007726-bqlf72fe	183	21	instillation	instillation	NN
cord-007726-bqlf72fe	183	22	[	[	-LRB-
cord-007726-bqlf72fe	183	23	58	58	CD
cord-007726-bqlf72fe	183	24	]	]	-RRB-
cord-007726-bqlf72fe	183	25	.	.	.
cord-007726-bqlf72fe	184	1	The	the	DT
cord-007726-bqlf72fe	184	2	benefits	benefit	NNS
cord-007726-bqlf72fe	184	3	of	of	IN
cord-007726-bqlf72fe	184	4	this	this	DT
cord-007726-bqlf72fe	184	5	model	model	NN
cord-007726-bqlf72fe	184	6	are	be	VBP
cord-007726-bqlf72fe	184	7	mainly	mainly	RB
cord-007726-bqlf72fe	184	8	related	relate	VBN
cord-007726-bqlf72fe	184	9	to	to	IN
cord-007726-bqlf72fe	184	10	the	the	DT
cord-007726-bqlf72fe	184	11	persistent	persistent	JJ
cord-007726-bqlf72fe	184	12	fibrosis	fibrosis	NN
cord-007726-bqlf72fe	184	13	that	that	WDT
cord-007726-bqlf72fe	184	14	does	do	VBZ
cord-007726-bqlf72fe	184	15	not	not	RB
cord-007726-bqlf72fe	184	16	appear	appear	VB
cord-007726-bqlf72fe	184	17	to	to	TO
cord-007726-bqlf72fe	184	18	be	be	VB
cord-007726-bqlf72fe	184	19	self	self	NN
cord-007726-bqlf72fe	184	20	-	-	HYPH
cord-007726-bqlf72fe	184	21	limiting	limit	VBG
cord-007726-bqlf72fe	184	22	,	,	,
cord-007726-bqlf72fe	184	23	thus	thus	RB
cord-007726-bqlf72fe	184	24	reflecting	reflect	VBG
cord-007726-bqlf72fe	184	25	the	the	DT
cord-007726-bqlf72fe	184	26	clinical	clinical	JJ
cord-007726-bqlf72fe	184	27	situation	situation	NN
cord-007726-bqlf72fe	184	28	,	,	,
cord-007726-bqlf72fe	184	29	and	and	CC
cord-007726-bqlf72fe	184	30	it	-PRON-	PRP
cord-007726-bqlf72fe	184	31	is	be	VBZ
cord-007726-bqlf72fe	184	32	also	also	RB
cord-007726-bqlf72fe	184	33	very	very	RB
cord-007726-bqlf72fe	184	34	easy	easy	JJ
cord-007726-bqlf72fe	184	35	to	to	TO
cord-007726-bqlf72fe	184	36	determine	determine	VB
cord-007726-bqlf72fe	184	37	which	which	WDT
cord-007726-bqlf72fe	184	38	part	part	NN
cord-007726-bqlf72fe	184	39	of	of	IN
cord-007726-bqlf72fe	184	40	the	the	DT
cord-007726-bqlf72fe	184	41	lung	lung	NN
cord-007726-bqlf72fe	184	42	has	have	VBZ
cord-007726-bqlf72fe	184	43	been	be	VBN
cord-007726-bqlf72fe	184	44	exposed	expose	VBN
cord-007726-bqlf72fe	184	45	to	to	IN
cord-007726-bqlf72fe	184	46	FITC	FITC	NNP
cord-007726-bqlf72fe	184	47	,	,	,
cord-007726-bqlf72fe	184	48	as	as	IN
cord-007726-bqlf72fe	184	49	the	the	DT
cord-007726-bqlf72fe	184	50	molecule	molecule	NN
cord-007726-bqlf72fe	184	51	is	be	VBZ
cord-007726-bqlf72fe	184	52	fluorescent	fluorescent	JJ
cord-007726-bqlf72fe	184	53	[	[	-LRB-
cord-007726-bqlf72fe	184	54	58	58	CD
cord-007726-bqlf72fe	184	55	]	]	-RRB-
cord-007726-bqlf72fe	184	56	.	.	.
cord-007726-bqlf72fe	185	1	It	-PRON-	PRP
cord-007726-bqlf72fe	185	2	is	be	VBZ
cord-007726-bqlf72fe	185	3	also	also	RB
cord-007726-bqlf72fe	185	4	an	an	DT
cord-007726-bqlf72fe	185	5	advantage	advantage	NN
cord-007726-bqlf72fe	185	6	that	that	WDT
cord-007726-bqlf72fe	185	7	both	both	DT
cord-007726-bqlf72fe	185	8	C57BL/6	C57BL/6	NNPS
cord-007726-bqlf72fe	185	9	and	and	CC
cord-007726-bqlf72fe	186	1	BALB	BALB	NNP
cord-007726-bqlf72fe	186	2	/	/	SYM
cord-007726-bqlf72fe	186	3	c	c	NN
cord-007726-bqlf72fe	186	4	mice	mouse	NNS
cord-007726-bqlf72fe	186	5	are	be	VBP
cord-007726-bqlf72fe	186	6	susceptible	susceptible	JJ
cord-007726-bqlf72fe	186	7	and	and	CC
cord-007726-bqlf72fe	186	8	develop	develop	VB
cord-007726-bqlf72fe	186	9	fibrosis	fibrosis	NN
cord-007726-bqlf72fe	186	10	following	follow	VBG
cord-007726-bqlf72fe	186	11	FITC	FITC	NNP
cord-007726-bqlf72fe	186	12	administration	administration	NN
cord-007726-bqlf72fe	186	13	[	[	-LRB-
cord-007726-bqlf72fe	186	14	56	56	CD
cord-007726-bqlf72fe	186	15	]	]	-RRB-
cord-007726-bqlf72fe	186	16	.	.	.
cord-007726-bqlf72fe	187	1	The	the	DT
cord-007726-bqlf72fe	187	2	disadvantages	disadvantage	NNS
cord-007726-bqlf72fe	187	3	of	of	IN
cord-007726-bqlf72fe	187	4	this	this	DT
cord-007726-bqlf72fe	187	5	model	model	NN
cord-007726-bqlf72fe	187	6	include	include	VBP
cord-007726-bqlf72fe	187	7	profound	profound	JJ
cord-007726-bqlf72fe	187	8	variability	variability	NN
cord-007726-bqlf72fe	187	9	due	due	IN
cord-007726-bqlf72fe	187	10	to	to	IN
cord-007726-bqlf72fe	187	11	differences	difference	NNS
cord-007726-bqlf72fe	187	12	between	between	IN
cord-007726-bqlf72fe	187	13	batches	batch	NNS
cord-007726-bqlf72fe	187	14	of	of	IN
cord-007726-bqlf72fe	187	15	FITC	FITC	NNP
cord-007726-bqlf72fe	187	16	,	,	,
cord-007726-bqlf72fe	187	17	as	as	RB
cord-007726-bqlf72fe	187	18	well	well	RB
cord-007726-bqlf72fe	187	19	as	as	IN
cord-007726-bqlf72fe	187	20	in	in	IN
cord-007726-bqlf72fe	187	21	the	the	DT
cord-007726-bqlf72fe	187	22	method	method	NN
cord-007726-bqlf72fe	187	23	used	use	VBN
cord-007726-bqlf72fe	187	24	to	to	TO
cord-007726-bqlf72fe	187	25	prepare	prepare	VB
cord-007726-bqlf72fe	187	26	the	the	DT
cord-007726-bqlf72fe	187	27	solution	solution	NN
cord-007726-bqlf72fe	187	28	before	before	IN
cord-007726-bqlf72fe	187	29	instillation	instillation	NN
cord-007726-bqlf72fe	187	30	.	.	.
cord-007726-bqlf72fe	188	1	Importantly	importantly	RB
cord-007726-bqlf72fe	188	2	,	,	,
cord-007726-bqlf72fe	188	3	given	give	VBN
cord-007726-bqlf72fe	188	4	the	the	DT
cord-007726-bqlf72fe	188	5	characteristics	characteristic	NNS
cord-007726-bqlf72fe	188	6	of	of	IN
cord-007726-bqlf72fe	188	7	the	the	DT
cord-007726-bqlf72fe	188	8	etiologic	etiologic	JJ
cord-007726-bqlf72fe	188	9	agent	agent	NN
cord-007726-bqlf72fe	188	10	used	use	VBD
cord-007726-bqlf72fe	188	11	to	to	TO
cord-007726-bqlf72fe	188	12	induce	induce	VB
cord-007726-bqlf72fe	188	13	this	this	DT
cord-007726-bqlf72fe	188	14	model	model	NN
cord-007726-bqlf72fe	188	15	of	of	IN
cord-007726-bqlf72fe	188	16	IPF	IPF	NNP
cord-007726-bqlf72fe	188	17	,	,	,
cord-007726-bqlf72fe	188	18	this	this	DT
cord-007726-bqlf72fe	188	19	model	model	NN
cord-007726-bqlf72fe	188	20	is	be	VBZ
cord-007726-bqlf72fe	188	21	considered	consider	VBN
cord-007726-bqlf72fe	188	22	a	a	DT
cord-007726-bqlf72fe	188	23	very	very	RB
cord-007726-bqlf72fe	188	24	artificial	artificial	JJ
cord-007726-bqlf72fe	188	25	system	system	NN
cord-007726-bqlf72fe	188	26	with	with	IN
cord-007726-bqlf72fe	188	27	limited	limited	JJ
cord-007726-bqlf72fe	188	28	clinical	clinical	JJ
cord-007726-bqlf72fe	188	29	relevance	relevance	NN
cord-007726-bqlf72fe	188	30	[	[	-LRB-
cord-007726-bqlf72fe	188	31	56	56	CD
cord-007726-bqlf72fe	188	32	]	]	-RRB-
cord-007726-bqlf72fe	188	33	.	.	.
cord-007726-bqlf72fe	189	1	Adenovirus	Adenovirus	NNP
cord-007726-bqlf72fe	189	2	vectors	vector	NNS
cord-007726-bqlf72fe	189	3	have	have	VBP
cord-007726-bqlf72fe	189	4	been	be	VBN
cord-007726-bqlf72fe	189	5	used	use	VBN
cord-007726-bqlf72fe	189	6	to	to	TO
cord-007726-bqlf72fe	189	7	overexpress	overexpress	VB
cord-007726-bqlf72fe	189	8	the	the	DT
cord-007726-bqlf72fe	189	9	pro	pro	JJ
cord-007726-bqlf72fe	189	10	-	-	JJ
cord-007726-bqlf72fe	189	11	fibrotic	fibrotic	JJ
cord-007726-bqlf72fe	189	12	cytokine	cytokine	NN
cord-007726-bqlf72fe	189	13	transforming	transform	VBG
cord-007726-bqlf72fe	189	14	growth	growth	NN
cord-007726-bqlf72fe	189	15	factor	factor	NN
cord-007726-bqlf72fe	189	16	(	(	-LRB-
cord-007726-bqlf72fe	189	17	TGF)-β	TGF)-β	NNP
cord-007726-bqlf72fe	189	18	,	,	,
cord-007726-bqlf72fe	189	19	which	which	WDT
cord-007726-bqlf72fe	189	20	results	result	VBZ
cord-007726-bqlf72fe	189	21	in	in	IN
cord-007726-bqlf72fe	189	22	pulmonary	pulmonary	JJ
cord-007726-bqlf72fe	189	23	fibrosis	fibrosis	NN
cord-007726-bqlf72fe	189	24	.	.	.
cord-007726-bqlf72fe	190	1	As	as	IN
cord-007726-bqlf72fe	190	2	TGF	TGF	NNP
cord-007726-bqlf72fe	190	3	-	-	HYPH
cord-007726-bqlf72fe	190	4	β	β	NN
cord-007726-bqlf72fe	190	5	overexpression	overexpression	NN
cord-007726-bqlf72fe	190	6	in	in	IN
cord-007726-bqlf72fe	190	7	the	the	DT
cord-007726-bqlf72fe	190	8	lungs	lung	NNS
cord-007726-bqlf72fe	190	9	is	be	VBZ
cord-007726-bqlf72fe	190	10	known	know	VBN
cord-007726-bqlf72fe	190	11	to	to	TO
cord-007726-bqlf72fe	190	12	be	be	VB
cord-007726-bqlf72fe	190	13	crucial	crucial	JJ
cord-007726-bqlf72fe	190	14	in	in	IN
cord-007726-bqlf72fe	190	15	the	the	DT
cord-007726-bqlf72fe	190	16	development	development	NN
cord-007726-bqlf72fe	190	17	of	of	IN
cord-007726-bqlf72fe	190	18	fibrosis	fibrosis	NN
cord-007726-bqlf72fe	190	19	in	in	IN
cord-007726-bqlf72fe	190	20	humans	human	NNS
cord-007726-bqlf72fe	190	21	[	[	-LRB-
cord-007726-bqlf72fe	190	22	62	62	CD
cord-007726-bqlf72fe	190	23	]	]	-RRB-
cord-007726-bqlf72fe	190	24	,	,	,
cord-007726-bqlf72fe	190	25	this	this	DT
cord-007726-bqlf72fe	190	26	model	model	NN
cord-007726-bqlf72fe	190	27	mimics	mimic	VBZ
cord-007726-bqlf72fe	190	28	an	an	DT
cord-007726-bqlf72fe	190	29	important	important	JJ
cord-007726-bqlf72fe	190	30	feature	feature	NN
cord-007726-bqlf72fe	190	31	of	of	IN
cord-007726-bqlf72fe	190	32	disease	disease	NN
cord-007726-bqlf72fe	190	33	etiology	etiology	NN
cord-007726-bqlf72fe	190	34	.	.	.
cord-007726-bqlf72fe	191	1	However	however	RB
cord-007726-bqlf72fe	191	2	,	,	,
cord-007726-bqlf72fe	191	3	the	the	DT
cord-007726-bqlf72fe	191	4	delivery	delivery	NN
cord-007726-bqlf72fe	191	5	system	system	NN
cord-007726-bqlf72fe	191	6	has	have	VBZ
cord-007726-bqlf72fe	191	7	some	some	DT
cord-007726-bqlf72fe	191	8	drawbacks	drawback	NNS
cord-007726-bqlf72fe	191	9	,	,	,
cord-007726-bqlf72fe	191	10	as	as	IN
cord-007726-bqlf72fe	191	11	the	the	DT
cord-007726-bqlf72fe	191	12	virus	virus	NN
cord-007726-bqlf72fe	191	13	itself	-PRON-	PRP
cord-007726-bqlf72fe	191	14	initiates	initiate	VBZ
cord-007726-bqlf72fe	191	15	an	an	DT
cord-007726-bqlf72fe	191	16	immune	immune	JJ
cord-007726-bqlf72fe	191	17	response	response	NN
cord-007726-bqlf72fe	191	18	.	.	.
cord-007726-bqlf72fe	192	1	Moreover	moreover	RB
cord-007726-bqlf72fe	192	2	,	,	,
cord-007726-bqlf72fe	192	3	adenoviruses	adenovirus	NNS
cord-007726-bqlf72fe	192	4	display	display	VBP
cord-007726-bqlf72fe	192	5	significant	significant	JJ
cord-007726-bqlf72fe	192	6	tropism	tropism	NN
cord-007726-bqlf72fe	192	7	for	for	IN
cord-007726-bqlf72fe	192	8	epithelial	epithelial	JJ
cord-007726-bqlf72fe	192	9	cells	cell	NNS
cord-007726-bqlf72fe	192	10	and	and	CC
cord-007726-bqlf72fe	192	11	rarely	rarely	RB
cord-007726-bqlf72fe	192	12	infect	infect	VBP
cord-007726-bqlf72fe	192	13	other	other	JJ
cord-007726-bqlf72fe	192	14	cell	cell	NN
cord-007726-bqlf72fe	192	15	types	type	NNS
cord-007726-bqlf72fe	192	16	such	such	JJ
cord-007726-bqlf72fe	192	17	as	as	IN
cord-007726-bqlf72fe	192	18	fibroblasts	fibroblast	NNS
cord-007726-bqlf72fe	192	19	[	[	-LRB-
cord-007726-bqlf72fe	192	20	58	58	CD
cord-007726-bqlf72fe	192	21	]	]	-RRB-
cord-007726-bqlf72fe	192	22	,	,	,
cord-007726-bqlf72fe	192	23	which	which	WDT
cord-007726-bqlf72fe	192	24	are	be	VBP
cord-007726-bqlf72fe	192	25	the	the	DT
cord-007726-bqlf72fe	192	26	cells	cell	NNS
cord-007726-bqlf72fe	192	27	meant	mean	VBN
cord-007726-bqlf72fe	192	28	to	to	TO
cord-007726-bqlf72fe	192	29	be	be	VB
cord-007726-bqlf72fe	192	30	targeted	target	VBN
cord-007726-bqlf72fe	192	31	in	in	IN
cord-007726-bqlf72fe	192	32	this	this	DT
cord-007726-bqlf72fe	192	33	model	model	NN
cord-007726-bqlf72fe	192	34	.	.	.
cord-007726-bqlf72fe	193	1	As	as	IN
cord-007726-bqlf72fe	193	2	TGF	TGF	NNP
cord-007726-bqlf72fe	193	3	-	-	HYPH
cord-007726-bqlf72fe	193	4	β	β	NNP
cord-007726-bqlf72fe	193	5	has	have	VBZ
cord-007726-bqlf72fe	193	6	major	major	JJ
cord-007726-bqlf72fe	193	7	effects	effect	NNS
cord-007726-bqlf72fe	193	8	on	on	IN
cord-007726-bqlf72fe	193	9	fibroblast	fibroblast	NN
cord-007726-bqlf72fe	193	10	biology	biology	NN
cord-007726-bqlf72fe	193	11	,	,	,
cord-007726-bqlf72fe	193	12	the	the	DT
cord-007726-bqlf72fe	193	13	main	main	JJ
cord-007726-bqlf72fe	193	14	feature	feature	NN
cord-007726-bqlf72fe	193	15	of	of	IN
cord-007726-bqlf72fe	193	16	this	this	DT
cord-007726-bqlf72fe	193	17	model	model	NN
cord-007726-bqlf72fe	193	18	is	be	VBZ
cord-007726-bqlf72fe	193	19	the	the	DT
cord-007726-bqlf72fe	193	20	effect	effect	NN
cord-007726-bqlf72fe	193	21	of	of	IN
cord-007726-bqlf72fe	193	22	epitheliumderived	epitheliumderived	JJ
cord-007726-bqlf72fe	193	23	TGF	TGF	NNP
cord-007726-bqlf72fe	193	24	-	-	HYPH
cord-007726-bqlf72fe	193	25	β	β	NN
cord-007726-bqlf72fe	193	26	on	on	IN
cord-007726-bqlf72fe	193	27	fibroblasts	fibroblast	NNS
cord-007726-bqlf72fe	193	28	and	and	CC
cord-007726-bqlf72fe	193	29	myofibroblasts	myofibroblast	NNS
cord-007726-bqlf72fe	193	30	,	,	,
cord-007726-bqlf72fe	193	31	resulting	result	VBG
cord-007726-bqlf72fe	193	32	in	in	IN
cord-007726-bqlf72fe	193	33	the	the	DT
cord-007726-bqlf72fe	193	34	deposition	deposition	NN
cord-007726-bqlf72fe	193	35	of	of	IN
cord-007726-bqlf72fe	193	36	ECM	ECM	NNP
cord-007726-bqlf72fe	193	37	proteins	protein	NNS
cord-007726-bqlf72fe	193	38	and	and	CC
cord-007726-bqlf72fe	193	39	areas	area	NNS
cord-007726-bqlf72fe	193	40	of	of	IN
cord-007726-bqlf72fe	193	41	dense	dense	JJ
cord-007726-bqlf72fe	193	42	fibrosis	fibrosis	NN
cord-007726-bqlf72fe	193	43	[	[	-LRB-
cord-007726-bqlf72fe	193	44	63	63	CD
cord-007726-bqlf72fe	193	45	]	]	-RRB-
cord-007726-bqlf72fe	193	46	.	.	.
cord-007726-bqlf72fe	194	1	An	an	DT
cord-007726-bqlf72fe	194	2	advantage	advantage	NN
cord-007726-bqlf72fe	194	3	of	of	IN
cord-007726-bqlf72fe	194	4	this	this	DT
cord-007726-bqlf72fe	194	5	model	model	NN
cord-007726-bqlf72fe	194	6	is	be	VBZ
cord-007726-bqlf72fe	194	7	the	the	DT
cord-007726-bqlf72fe	194	8	relatively	relatively	RB
cord-007726-bqlf72fe	194	9	low	low	JJ
cord-007726-bqlf72fe	194	10	degree	degree	NN
cord-007726-bqlf72fe	194	11	of	of	IN
cord-007726-bqlf72fe	194	12	inflammation	inflammation	NN
cord-007726-bqlf72fe	194	13	,	,	,
cord-007726-bqlf72fe	194	14	as	as	RB
cord-007726-bqlf72fe	194	15	well	well	RB
cord-007726-bqlf72fe	194	16	as	as	IN
cord-007726-bqlf72fe	194	17	what	what	WP
cord-007726-bqlf72fe	194	18	appears	appear	VBZ
cord-007726-bqlf72fe	194	19	to	to	TO
cord-007726-bqlf72fe	194	20	be	be	VB
cord-007726-bqlf72fe	194	21	a	a	DT
cord-007726-bqlf72fe	194	22	direct	direct	JJ
cord-007726-bqlf72fe	194	23	effect	effect	NN
cord-007726-bqlf72fe	194	24	on	on	IN
cord-007726-bqlf72fe	194	25	fibroblasts/	fibroblasts/	CD
cord-007726-bqlf72fe	194	26	myofibroblasts	myofibroblast	NNS
cord-007726-bqlf72fe	194	27	[	[	-LRB-
cord-007726-bqlf72fe	194	28	63	63	CD
cord-007726-bqlf72fe	194	29	]	]	-RRB-
cord-007726-bqlf72fe	194	30	,	,	,
cord-007726-bqlf72fe	194	31	which	which	WDT
cord-007726-bqlf72fe	194	32	is	be	VBZ
cord-007726-bqlf72fe	194	33	in	in	IN
cord-007726-bqlf72fe	194	34	accordance	accordance	NN
cord-007726-bqlf72fe	194	35	with	with	IN
cord-007726-bqlf72fe	194	36	the	the	DT
cord-007726-bqlf72fe	194	37	clinical	clinical	JJ
cord-007726-bqlf72fe	194	38	situation	situation	NN
cord-007726-bqlf72fe	194	39	(	(	-LRB-
cord-007726-bqlf72fe	194	40	as	as	IN
cord-007726-bqlf72fe	194	41	we	-PRON-	PRP
cord-007726-bqlf72fe	194	42	understand	understand	VBP
cord-007726-bqlf72fe	194	43	it	-PRON-	PRP
cord-007726-bqlf72fe	194	44	today	today	NN
cord-007726-bqlf72fe	194	45	)	)	-RRB-
cord-007726-bqlf72fe	194	46	.	.	.
cord-007726-bqlf72fe	195	1	Silica	silica	NN
cord-007726-bqlf72fe	195	2	administration	administration	NN
cord-007726-bqlf72fe	195	3	induces	induce	VBZ
cord-007726-bqlf72fe	195	4	a	a	DT
cord-007726-bqlf72fe	195	5	similar	similar	JJ
cord-007726-bqlf72fe	195	6	pathology	pathology	NN
cord-007726-bqlf72fe	195	7	in	in	IN
cord-007726-bqlf72fe	195	8	mouse	mouse	NN
cord-007726-bqlf72fe	195	9	lungs	lung	NNS
cord-007726-bqlf72fe	195	10	as	as	IN
cord-007726-bqlf72fe	195	11	in	in	IN
cord-007726-bqlf72fe	195	12	humans	human	NNS
cord-007726-bqlf72fe	195	13	exposed	expose	VBN
cord-007726-bqlf72fe	195	14	to	to	IN
cord-007726-bqlf72fe	195	15	silica	silica	NN
cord-007726-bqlf72fe	195	16	,	,	,
cord-007726-bqlf72fe	195	17	and	and	CC
cord-007726-bqlf72fe	195	18	as	as	IN
cord-007726-bqlf72fe	195	19	is	be	VBZ
cord-007726-bqlf72fe	195	20	also	also	RB
cord-007726-bqlf72fe	195	21	observed	observe	VBN
cord-007726-bqlf72fe	195	22	in	in	IN
cord-007726-bqlf72fe	195	23	human	human	JJ
cord-007726-bqlf72fe	195	24	silicainduced	silicainduce	VBN
cord-007726-bqlf72fe	195	25	fibrosis	fibrosis	NN
cord-007726-bqlf72fe	195	26	,	,	,
cord-007726-bqlf72fe	195	27	structural	structural	JJ
cord-007726-bqlf72fe	195	28	remodeling	remodeling	NN
cord-007726-bqlf72fe	195	29	persists	persist	VBZ
cord-007726-bqlf72fe	195	30	when	when	WRB
cord-007726-bqlf72fe	195	31	administration	administration	NN
cord-007726-bqlf72fe	195	32	is	be	VBZ
cord-007726-bqlf72fe	195	33	halted	halt	VBN
cord-007726-bqlf72fe	195	34	[	[	-LRB-
cord-007726-bqlf72fe	195	35	56	56	CD
cord-007726-bqlf72fe	195	36	]	]	-RRB-
cord-007726-bqlf72fe	195	37	.	.	.
cord-007726-bqlf72fe	196	1	Following	follow	VBG
cord-007726-bqlf72fe	196	2	the	the	DT
cord-007726-bqlf72fe	196	3	administration	administration	NN
cord-007726-bqlf72fe	196	4	of	of	IN
cord-007726-bqlf72fe	196	5	silica	silica	NN
cord-007726-bqlf72fe	196	6	particles	particle	NNS
cord-007726-bqlf72fe	196	7	,	,	,
cord-007726-bqlf72fe	196	8	fibrotic	fibrotic	JJ
cord-007726-bqlf72fe	196	9	nodules	nodule	NNS
cord-007726-bqlf72fe	196	10	develop	develop	VBP
cord-007726-bqlf72fe	196	11	in	in	IN
cord-007726-bqlf72fe	196	12	mouse	mouse	NN
cord-007726-bqlf72fe	196	13	lungs	lung	NNS
cord-007726-bqlf72fe	196	14	,	,	,
cord-007726-bqlf72fe	196	15	with	with	IN
cord-007726-bqlf72fe	196	16	considerable	considerable	JJ
cord-007726-bqlf72fe	196	17	resemblance	resemblance	NN
cord-007726-bqlf72fe	196	18	to	to	IN
cord-007726-bqlf72fe	196	19	the	the	DT
cord-007726-bqlf72fe	196	20	human	human	JJ
cord-007726-bqlf72fe	196	21	lesions	lesion	NNS
cord-007726-bqlf72fe	196	22	that	that	WDT
cord-007726-bqlf72fe	196	23	develop	develop	VBP
cord-007726-bqlf72fe	196	24	after	after	IN
cord-007726-bqlf72fe	196	25	exposure	exposure	NN
cord-007726-bqlf72fe	196	26	to	to	IN
cord-007726-bqlf72fe	196	27	mineral	mineral	NN
cord-007726-bqlf72fe	196	28	fibers	fiber	NNS
cord-007726-bqlf72fe	196	29	[	[	-LRB-
cord-007726-bqlf72fe	196	30	56	56	CD
cord-007726-bqlf72fe	196	31	]	]	-RRB-
cord-007726-bqlf72fe	196	32	.	.	.
cord-007726-bqlf72fe	197	1	The	the	DT
cord-007726-bqlf72fe	197	2	fibrotic	fibrotic	JJ
cord-007726-bqlf72fe	197	3	response	response	NN
cord-007726-bqlf72fe	197	4	is	be	VBZ
cord-007726-bqlf72fe	197	5	accompanied	accompany	VBN
cord-007726-bqlf72fe	197	6	by	by	IN
cord-007726-bqlf72fe	197	7	a	a	DT
cord-007726-bqlf72fe	197	8	limited	limited	JJ
cord-007726-bqlf72fe	197	9	inflammatory	inflammatory	JJ
cord-007726-bqlf72fe	197	10	response	response	NN
cord-007726-bqlf72fe	197	11	,	,	,
cord-007726-bqlf72fe	197	12	and	and	CC
cord-007726-bqlf72fe	197	13	different	different	JJ
cord-007726-bqlf72fe	197	14	pro	pro	JJ
cord-007726-bqlf72fe	197	15	-	-	JJ
cord-007726-bqlf72fe	197	16	fibrotic	fibrotic	JJ
cord-007726-bqlf72fe	197	17	cytokines	cytokine	NNS
cord-007726-bqlf72fe	197	18	such	such	JJ
cord-007726-bqlf72fe	197	19	as	as	IN
cord-007726-bqlf72fe	197	20	TGF	TGF	NNP
cord-007726-bqlf72fe	197	21	-	-	HYPH
cord-007726-bqlf72fe	197	22	β	β	NN
cord-007726-bqlf72fe	197	23	,	,	,
cord-007726-bqlf72fe	197	24	platelet	platelet	NN
cord-007726-bqlf72fe	197	25	-	-	HYPH
cord-007726-bqlf72fe	197	26	derived	derive	VBN
cord-007726-bqlf72fe	197	27	growth	growth	NN
cord-007726-bqlf72fe	197	28	factor	factor	NN
cord-007726-bqlf72fe	197	29	,	,	,
cord-007726-bqlf72fe	197	30	and	and	CC
cord-007726-bqlf72fe	197	31	IL-10	IL-10	NNP
cord-007726-bqlf72fe	197	32	are	be	VBP
cord-007726-bqlf72fe	197	33	involved	involve	VBN
cord-007726-bqlf72fe	197	34	in	in	IN
cord-007726-bqlf72fe	197	35	disease	disease	NN
cord-007726-bqlf72fe	197	36	development	development	NN
cord-007726-bqlf72fe	197	37	,	,	,
cord-007726-bqlf72fe	197	38	which	which	WDT
cord-007726-bqlf72fe	197	39	is	be	VBZ
cord-007726-bqlf72fe	197	40	in	in	IN
cord-007726-bqlf72fe	197	41	accordance	accordance	NN
cord-007726-bqlf72fe	197	42	with	with	IN
cord-007726-bqlf72fe	197	43	the	the	DT
cord-007726-bqlf72fe	197	44	clinical	clinical	JJ
cord-007726-bqlf72fe	197	45	situation	situation	NN
cord-007726-bqlf72fe	197	46	[	[	-LRB-
cord-007726-bqlf72fe	197	47	56	56	CD
cord-007726-bqlf72fe	197	48	]	]	-RRB-
cord-007726-bqlf72fe	197	49	.	.	.
cord-007726-bqlf72fe	198	1	Another	another	DT
cord-007726-bqlf72fe	198	2	advantage	advantage	NN
cord-007726-bqlf72fe	198	3	is	be	VBZ
cord-007726-bqlf72fe	198	4	that	that	IN
cord-007726-bqlf72fe	198	5	nodules	nodule	NNS
cord-007726-bqlf72fe	198	6	develop	develop	VBP
cord-007726-bqlf72fe	198	7	around	around	IN
cord-007726-bqlf72fe	198	8	silica	silica	NN
cord-007726-bqlf72fe	198	9	fibers	fiber	NNS
cord-007726-bqlf72fe	198	10	,	,	,
cord-007726-bqlf72fe	198	11	and	and	CC
cord-007726-bqlf72fe	198	12	these	these	DT
cord-007726-bqlf72fe	198	13	fibers	fiber	NNS
cord-007726-bqlf72fe	198	14	are	be	VBP
cord-007726-bqlf72fe	198	15	easy	easy	JJ
cord-007726-bqlf72fe	198	16	to	to	TO
cord-007726-bqlf72fe	198	17	identify	identify	VB
cord-007726-bqlf72fe	198	18	by	by	IN
cord-007726-bqlf72fe	198	19	light	light	JJ
cord-007726-bqlf72fe	198	20	microscopy	microscopy	NNS
cord-007726-bqlf72fe	198	21	.	.	.
cord-007726-bqlf72fe	199	1	The	the	DT
cord-007726-bqlf72fe	199	2	response	response	NN
cord-007726-bqlf72fe	199	3	in	in	IN
cord-007726-bqlf72fe	199	4	this	this	DT
cord-007726-bqlf72fe	199	5	model	model	NN
cord-007726-bqlf72fe	199	6	is	be	VBZ
cord-007726-bqlf72fe	199	7	strain	strain	NN
cord-007726-bqlf72fe	199	8	-	-	HYPH
cord-007726-bqlf72fe	199	9	dependent	dependent	JJ
cord-007726-bqlf72fe	199	10	,	,	,
cord-007726-bqlf72fe	199	11	with	with	IN
cord-007726-bqlf72fe	199	12	C57BL/6	C57BL/6	NNP
cord-007726-bqlf72fe	199	13	mice	mouse	NNS
cord-007726-bqlf72fe	199	14	being	be	VBG
cord-007726-bqlf72fe	199	15	the	the	DT
cord-007726-bqlf72fe	199	16	most	most	RBS
cord-007726-bqlf72fe	199	17	susceptible	susceptible	JJ
cord-007726-bqlf72fe	199	18	.	.	.
cord-007726-bqlf72fe	200	1	The	the	DT
cord-007726-bqlf72fe	200	2	main	main	JJ
cord-007726-bqlf72fe	200	3	drawbacks	drawback	NNS
cord-007726-bqlf72fe	200	4	are	be	VBP
cord-007726-bqlf72fe	200	5	the	the	DT
cord-007726-bqlf72fe	200	6	time	time	NN
cord-007726-bqlf72fe	200	7	required	require	VBN
cord-007726-bqlf72fe	200	8	to	to	TO
cord-007726-bqlf72fe	200	9	establish	establish	VB
cord-007726-bqlf72fe	200	10	disease	disease	NN
cord-007726-bqlf72fe	200	11	,	,	,
cord-007726-bqlf72fe	200	12	i.e.	i.e.	FW
cord-007726-bqlf72fe	200	13	,	,	,
cord-007726-bqlf72fe	200	14	30	30	CD
cord-007726-bqlf72fe	200	15	-	-	SYM
cord-007726-bqlf72fe	200	16	60	60	CD
cord-007726-bqlf72fe	200	17	days	day	NNS
cord-007726-bqlf72fe	200	18	,	,	,
cord-007726-bqlf72fe	200	19	and	and	CC
cord-007726-bqlf72fe	200	20	the	the	DT
cord-007726-bqlf72fe	200	21	need	need	NN
cord-007726-bqlf72fe	200	22	for	for	IN
cord-007726-bqlf72fe	200	23	special	special	JJ
cord-007726-bqlf72fe	200	24	equipment	equipment	NN
cord-007726-bqlf72fe	200	25	to	to	TO
cord-007726-bqlf72fe	200	26	aerosolize	aerosolize	VB
cord-007726-bqlf72fe	200	27	the	the	DT
cord-007726-bqlf72fe	200	28	silica	silica	NN
cord-007726-bqlf72fe	200	29	particles	particle	NNS
cord-007726-bqlf72fe	200	30	.	.	.
cord-007726-bqlf72fe	201	1	However	however	RB
cord-007726-bqlf72fe	201	2	,	,	,
cord-007726-bqlf72fe	201	3	since	since	IN
cord-007726-bqlf72fe	201	4	the	the	DT
cord-007726-bqlf72fe	201	5	route	route	NN
cord-007726-bqlf72fe	201	6	of	of	IN
cord-007726-bqlf72fe	201	7	administration	administration	NN
cord-007726-bqlf72fe	201	8	,	,	,
cord-007726-bqlf72fe	201	9	the	the	DT
cord-007726-bqlf72fe	201	10	driving	drive	VBG
cord-007726-bqlf72fe	201	11	etiologic	etiologic	JJ
cord-007726-bqlf72fe	201	12	agent	agent	NN
cord-007726-bqlf72fe	201	13	,	,	,
cord-007726-bqlf72fe	201	14	and	and	CC
cord-007726-bqlf72fe	201	15	the	the	DT
cord-007726-bqlf72fe	201	16	resulting	result	VBG
cord-007726-bqlf72fe	201	17	pathobiology	pathobiology	NN
cord-007726-bqlf72fe	201	18	are	be	VBP
cord-007726-bqlf72fe	201	19	all	all	RB
cord-007726-bqlf72fe	201	20	similar	similar	JJ
cord-007726-bqlf72fe	201	21	to	to	IN
cord-007726-bqlf72fe	201	22	the	the	DT
cord-007726-bqlf72fe	201	23	characteristics	characteristic	NNS
cord-007726-bqlf72fe	201	24	of	of	IN
cord-007726-bqlf72fe	201	25	this	this	DT
cord-007726-bqlf72fe	201	26	subtype	subtype	NN
cord-007726-bqlf72fe	201	27	of	of	IN
cord-007726-bqlf72fe	201	28	pulmonary	pulmonary	JJ
cord-007726-bqlf72fe	201	29	fibrosis	fibrosis	NN
cord-007726-bqlf72fe	201	30	[	[	-LRB-
cord-007726-bqlf72fe	201	31	56	56	CD
cord-007726-bqlf72fe	201	32	,	,	,
cord-007726-bqlf72fe	201	33	58	58	CD
cord-007726-bqlf72fe	201	34	]	]	-RRB-
cord-007726-bqlf72fe	201	35	,	,	,
cord-007726-bqlf72fe	201	36	the	the	DT
cord-007726-bqlf72fe	201	37	silica	silica	NN
cord-007726-bqlf72fe	201	38	exposure	exposure	NN
cord-007726-bqlf72fe	201	39	model	model	NN
cord-007726-bqlf72fe	201	40	can	can	MD
cord-007726-bqlf72fe	201	41	be	be	VB
cord-007726-bqlf72fe	201	42	considered	consider	VBN
cord-007726-bqlf72fe	201	43	to	to	TO
cord-007726-bqlf72fe	201	44	have	have	VB
cord-007726-bqlf72fe	201	45	very	very	RB
cord-007726-bqlf72fe	201	46	good	good	JJ
cord-007726-bqlf72fe	201	47	clinical	clinical	JJ
cord-007726-bqlf72fe	201	48	relevance	relevance	NN
cord-007726-bqlf72fe	201	49	.	.	.
cord-007726-bqlf72fe	202	1	7	7	CD
cord-007726-bqlf72fe	203	1	What	what	WP
cord-007726-bqlf72fe	203	2	Does	do	VBZ
cord-007726-bqlf72fe	203	3	the	the	DT
cord-007726-bqlf72fe	203	4	Future	Future	NNP
cord-007726-bqlf72fe	203	5	Hold	Hold	NNP
cord-007726-bqlf72fe	203	6	for	for	IN
cord-007726-bqlf72fe	203	7	Mouse	Mouse	NNP
cord-007726-bqlf72fe	203	8	Models	Models	NNPS
cord-007726-bqlf72fe	203	9	of	of	IN
cord-007726-bqlf72fe	203	10	Human	Human	NNP
cord-007726-bqlf72fe	203	11	Disease	Disease	NNP
cord-007726-bqlf72fe	203	12	?	?	.
cord-007726-bqlf72fe	204	1	Medical	medical	JJ
cord-007726-bqlf72fe	204	2	research	research	NN
cord-007726-bqlf72fe	204	3	using	use	VBG
cord-007726-bqlf72fe	204	4	experimental	experimental	JJ
cord-007726-bqlf72fe	204	5	animals	animal	NNS
cord-007726-bqlf72fe	204	6	(	(	-LRB-
cord-007726-bqlf72fe	204	7	not	not	RB
cord-007726-bqlf72fe	204	8	only	only	RB
cord-007726-bqlf72fe	204	9	mice	mouse	NNS
cord-007726-bqlf72fe	204	10	but	but	CC
cord-007726-bqlf72fe	204	11	other	other	JJ
cord-007726-bqlf72fe	204	12	animals	animal	NNS
cord-007726-bqlf72fe	204	13	including	include	VBG
cord-007726-bqlf72fe	204	14	rats	rat	NNS
cord-007726-bqlf72fe	204	15	,	,	,
cord-007726-bqlf72fe	204	16	guinea	guinea	NN
cord-007726-bqlf72fe	204	17	pigs	pig	NNS
cord-007726-bqlf72fe	204	18	,	,	,
cord-007726-bqlf72fe	204	19	zebrafish	zebrafish	NN
cord-007726-bqlf72fe	204	20	,	,	,
cord-007726-bqlf72fe	204	21	and	and	CC
cord-007726-bqlf72fe	204	22	fruit	fruit	NN
cord-007726-bqlf72fe	204	23	flies	fly	NNS
cord-007726-bqlf72fe	204	24	)	)	-RRB-
cord-007726-bqlf72fe	204	25	has	have	VBZ
cord-007726-bqlf72fe	204	26	greatly	greatly	RB
cord-007726-bqlf72fe	204	27	contributed	contribute	VBN
cord-007726-bqlf72fe	204	28	to	to	IN
cord-007726-bqlf72fe	204	29	many	many	JJ
cord-007726-bqlf72fe	204	30	important	important	JJ
cord-007726-bqlf72fe	204	31	scientific	scientific	JJ
cord-007726-bqlf72fe	204	32	and	and	CC
cord-007726-bqlf72fe	204	33	medical	medical	JJ
cord-007726-bqlf72fe	204	34	advances	advance	NNS
cord-007726-bqlf72fe	204	35	in	in	IN
cord-007726-bqlf72fe	204	36	the	the	DT
cord-007726-bqlf72fe	204	37	past	past	JJ
cord-007726-bqlf72fe	204	38	century	century	NN
cord-007726-bqlf72fe	204	39	and	and	CC
cord-007726-bqlf72fe	204	40	will	will	MD
cord-007726-bqlf72fe	204	41	continue	continue	VB
cord-007726-bqlf72fe	204	42	to	to	TO
cord-007726-bqlf72fe	204	43	do	do	VB
cord-007726-bqlf72fe	204	44	so	so	RB
cord-007726-bqlf72fe	204	45	into	into	IN
cord-007726-bqlf72fe	204	46	the	the	DT
cord-007726-bqlf72fe	204	47	near	near	JJ
cord-007726-bqlf72fe	204	48	future	future	NN
cord-007726-bqlf72fe	204	49	.	.	.
cord-007726-bqlf72fe	205	1	These	these	DT
cord-007726-bqlf72fe	205	2	advances	advance	NNS
cord-007726-bqlf72fe	205	3	have	have	VBP
cord-007726-bqlf72fe	205	4	contributed	contribute	VBN
cord-007726-bqlf72fe	205	5	to	to	IN
cord-007726-bqlf72fe	205	6	the	the	DT
cord-007726-bqlf72fe	205	7	development	development	NN
cord-007726-bqlf72fe	205	8	of	of	IN
cord-007726-bqlf72fe	205	9	new	new	JJ
cord-007726-bqlf72fe	205	10	medicines	medicine	NNS
cord-007726-bqlf72fe	205	11	and	and	CC
cord-007726-bqlf72fe	205	12	treatments	treatment	NNS
cord-007726-bqlf72fe	205	13	for	for	IN
cord-007726-bqlf72fe	205	14	human	human	JJ
cord-007726-bqlf72fe	205	15	disease	disease	NN
cord-007726-bqlf72fe	205	16	and	and	CC
cord-007726-bqlf72fe	205	17	have	have	VBP
cord-007726-bqlf72fe	205	18	therefore	therefore	RB
cord-007726-bqlf72fe	205	19	played	play	VBN
cord-007726-bqlf72fe	205	20	a	a	DT
cord-007726-bqlf72fe	205	21	vital	vital	JJ
cord-007726-bqlf72fe	205	22	role	role	NN
cord-007726-bqlf72fe	205	23	in	in	IN
cord-007726-bqlf72fe	205	24	increasing	increase	VBG
cord-007726-bqlf72fe	205	25	the	the	DT
cord-007726-bqlf72fe	205	26	human	human	JJ
cord-007726-bqlf72fe	205	27	life	life	NN
cord-007726-bqlf72fe	205	28	span	span	NN
cord-007726-bqlf72fe	205	29	and	and	CC
cord-007726-bqlf72fe	205	30	improving	improve	VBG
cord-007726-bqlf72fe	205	31	quality	quality	NN
cord-007726-bqlf72fe	205	32	of	of	IN
cord-007726-bqlf72fe	205	33	life	life	NN
cord-007726-bqlf72fe	205	34	.	.	.
cord-007726-bqlf72fe	206	1	Despite	despite	IN
cord-007726-bqlf72fe	206	2	the	the	DT
cord-007726-bqlf72fe	206	3	acknowledged	acknowledge	VBN
cord-007726-bqlf72fe	206	4	benefits	benefit	NNS
cord-007726-bqlf72fe	206	5	of	of	IN
cord-007726-bqlf72fe	206	6	performing	perform	VBG
cord-007726-bqlf72fe	206	7	research	research	NN
cord-007726-bqlf72fe	206	8	using	use	VBG
cord-007726-bqlf72fe	206	9	experimental	experimental	JJ
cord-007726-bqlf72fe	206	10	animals	animal	NNS
cord-007726-bqlf72fe	206	11	,	,	,
cord-007726-bqlf72fe	206	12	a	a	DT
cord-007726-bqlf72fe	206	13	number	number	NN
cord-007726-bqlf72fe	206	14	of	of	IN
cord-007726-bqlf72fe	206	15	considerations	consideration	NNS
cord-007726-bqlf72fe	206	16	must	must	MD
cord-007726-bqlf72fe	206	17	be	be	VB
cord-007726-bqlf72fe	206	18	made	make	VBN
cord-007726-bqlf72fe	206	19	before	before	IN
cord-007726-bqlf72fe	206	20	embarking	embark	VBG
cord-007726-bqlf72fe	206	21	on	on	IN
cord-007726-bqlf72fe	206	22	this	this	DT
cord-007726-bqlf72fe	206	23	type	type	NN
cord-007726-bqlf72fe	206	24	of	of	IN
cord-007726-bqlf72fe	206	25	research	research	NN
cord-007726-bqlf72fe	206	26	.	.	.
cord-007726-bqlf72fe	207	1	Of	of	RB
cord-007726-bqlf72fe	207	2	course	course	RB
cord-007726-bqlf72fe	207	3	,	,	,
cord-007726-bqlf72fe	207	4	the	the	DT
cord-007726-bqlf72fe	207	5	financial	financial	JJ
cord-007726-bqlf72fe	207	6	aspects	aspect	NNS
cord-007726-bqlf72fe	207	7	of	of	IN
cord-007726-bqlf72fe	207	8	conducting	conduct	VBG
cord-007726-bqlf72fe	207	9	this	this	DT
cord-007726-bqlf72fe	207	10	type	type	NN
cord-007726-bqlf72fe	207	11	of	of	IN
cord-007726-bqlf72fe	207	12	work	work	NN
cord-007726-bqlf72fe	207	13	are	be	VBP
cord-007726-bqlf72fe	207	14	an	an	DT
cord-007726-bqlf72fe	207	15	important	important	JJ
cord-007726-bqlf72fe	207	16	limitation	limitation	NN
cord-007726-bqlf72fe	207	17	,	,	,
cord-007726-bqlf72fe	207	18	as	as	IN
cord-007726-bqlf72fe	207	19	the	the	DT
cord-007726-bqlf72fe	207	20	costs	cost	NNS
cord-007726-bqlf72fe	207	21	of	of	IN
cord-007726-bqlf72fe	207	22	purchasing	purchasing	NN
cord-007726-bqlf72fe	207	23	and	and	CC
cord-007726-bqlf72fe	207	24	housing	housing	NN
cord-007726-bqlf72fe	207	25	mice	mouse	NNS
cord-007726-bqlf72fe	207	26	can	can	MD
cord-007726-bqlf72fe	207	27	be	be	VB
cord-007726-bqlf72fe	207	28	prohibitive	prohibitive	JJ
cord-007726-bqlf72fe	207	29	,	,	,
cord-007726-bqlf72fe	207	30	especially	especially	RB
cord-007726-bqlf72fe	207	31	when	when	WRB
cord-007726-bqlf72fe	207	32	genetically	genetically	RB
cord-007726-bqlf72fe	207	33	modified	modify	VBN
cord-007726-bqlf72fe	207	34	mice	mouse	NNS
cord-007726-bqlf72fe	207	35	and	and	CC
cord-007726-bqlf72fe	207	36	colony	colony	NN
cord-007726-bqlf72fe	207	37	maintenance	maintenance	NN
cord-007726-bqlf72fe	207	38	are	be	VBP
cord-007726-bqlf72fe	207	39	required	require	VBN
cord-007726-bqlf72fe	207	40	for	for	IN
cord-007726-bqlf72fe	207	41	the	the	DT
cord-007726-bqlf72fe	207	42	study	study	NN
cord-007726-bqlf72fe	207	43	.	.	.
cord-007726-bqlf72fe	208	1	The	the	DT
cord-007726-bqlf72fe	208	2	practicalities	practicality	NNS
cord-007726-bqlf72fe	208	3	of	of	IN
cord-007726-bqlf72fe	208	4	working	work	VBG
cord-007726-bqlf72fe	208	5	with	with	IN
cord-007726-bqlf72fe	208	6	animals	animal	NNS
cord-007726-bqlf72fe	208	7	such	such	JJ
cord-007726-bqlf72fe	208	8	as	as	IN
cord-007726-bqlf72fe	208	9	mice	mouse	NNS
cord-007726-bqlf72fe	208	10	may	may	MD
cord-007726-bqlf72fe	208	11	also	also	RB
cord-007726-bqlf72fe	208	12	be	be	VB
cord-007726-bqlf72fe	208	13	an	an	DT
cord-007726-bqlf72fe	208	14	issue	issue	NN
cord-007726-bqlf72fe	208	15	,	,	,
cord-007726-bqlf72fe	208	16	as	as	IN
cord-007726-bqlf72fe	208	17	this	this	DT
cord-007726-bqlf72fe	208	18	type	type	NN
cord-007726-bqlf72fe	208	19	of	of	IN
cord-007726-bqlf72fe	208	20	work	work	NN
cord-007726-bqlf72fe	208	21	requires	require	VBZ
cord-007726-bqlf72fe	208	22	specialized	specialized	JJ
cord-007726-bqlf72fe	208	23	facilities	facility	NNS
cord-007726-bqlf72fe	208	24	,	,	,
cord-007726-bqlf72fe	208	25	equipment	equipment	NN
cord-007726-bqlf72fe	208	26	,	,	,
cord-007726-bqlf72fe	208	27	and	and	CC
cord-007726-bqlf72fe	208	28	staff	staff	NN
cord-007726-bqlf72fe	208	29	to	to	TO
cord-007726-bqlf72fe	208	30	ensure	ensure	VB
cord-007726-bqlf72fe	208	31	studies	study	NNS
cord-007726-bqlf72fe	208	32	are	be	VBP
cord-007726-bqlf72fe	208	33	carried	carry	VBN
cord-007726-bqlf72fe	208	34	out	out	RP
cord-007726-bqlf72fe	208	35	in	in	IN
cord-007726-bqlf72fe	208	36	a	a	DT
cord-007726-bqlf72fe	208	37	manner	manner	NN
cord-007726-bqlf72fe	208	38	that	that	WDT
cord-007726-bqlf72fe	208	39	is	be	VBZ
cord-007726-bqlf72fe	208	40	safe	safe	JJ
cord-007726-bqlf72fe	208	41	for	for	IN
cord-007726-bqlf72fe	208	42	both	both	CC
cord-007726-bqlf72fe	208	43	the	the	DT
cord-007726-bqlf72fe	208	44	researchers	researcher	NNS
cord-007726-bqlf72fe	208	45	and	and	CC
cord-007726-bqlf72fe	208	46	the	the	DT
cord-007726-bqlf72fe	208	47	animals	animal	NNS
cord-007726-bqlf72fe	208	48	.	.	.
cord-007726-bqlf72fe	209	1	Moreover	moreover	RB
cord-007726-bqlf72fe	209	2	,	,	,
cord-007726-bqlf72fe	209	3	as	as	IN
cord-007726-bqlf72fe	209	4	discussed	discuss	VBN
cord-007726-bqlf72fe	209	5	in	in	IN
cord-007726-bqlf72fe	209	6	detail	detail	NN
cord-007726-bqlf72fe	209	7	in	in	IN
cord-007726-bqlf72fe	209	8	this	this	DT
cord-007726-bqlf72fe	209	9	chapter	chapter	NN
cord-007726-bqlf72fe	209	10	,	,	,
cord-007726-bqlf72fe	209	11	the	the	DT
cord-007726-bqlf72fe	209	12	relevance	relevance	NN
cord-007726-bqlf72fe	209	13	of	of	IN
cord-007726-bqlf72fe	209	14	the	the	DT
cord-007726-bqlf72fe	209	15	selected	select	VBN
cord-007726-bqlf72fe	209	16	animal	animal	NN
cord-007726-bqlf72fe	209	17	model	model	NN
cord-007726-bqlf72fe	209	18	to	to	IN
cord-007726-bqlf72fe	209	19	human	human	JJ
cord-007726-bqlf72fe	209	20	disease	disease	NN
cord-007726-bqlf72fe	209	21	must	must	MD
cord-007726-bqlf72fe	209	22	be	be	VB
cord-007726-bqlf72fe	209	23	carefully	carefully	RB
cord-007726-bqlf72fe	209	24	evaluated	evaluate	VBN
cord-007726-bqlf72fe	209	25	to	to	TO
cord-007726-bqlf72fe	209	26	ensure	ensure	VB
cord-007726-bqlf72fe	209	27	that	that	IN
cord-007726-bqlf72fe	209	28	these	these	DT
cord-007726-bqlf72fe	209	29	experiments	experiment	NNS
cord-007726-bqlf72fe	209	30	provide	provide	VBP
cord-007726-bqlf72fe	209	31	robust	robust	JJ
cord-007726-bqlf72fe	209	32	results	result	NNS
cord-007726-bqlf72fe	209	33	that	that	WDT
cord-007726-bqlf72fe	209	34	are	be	VBP
cord-007726-bqlf72fe	209	35	translatable	translatable	JJ
cord-007726-bqlf72fe	209	36	to	to	IN
cord-007726-bqlf72fe	209	37	human	human	JJ
cord-007726-bqlf72fe	209	38	health	health	NN
cord-007726-bqlf72fe	209	39	and	and	CC
cord-007726-bqlf72fe	209	40	disease	disease	NN
cord-007726-bqlf72fe	209	41	.	.	.
cord-007726-bqlf72fe	210	1	Another	another	DT
cord-007726-bqlf72fe	210	2	important	important	JJ
cord-007726-bqlf72fe	210	3	and	and	CC
cord-007726-bqlf72fe	210	4	demanding	demanding	JJ
cord-007726-bqlf72fe	210	5	aspect	aspect	NN
cord-007726-bqlf72fe	210	6	of	of	IN
cord-007726-bqlf72fe	210	7	biomedical	biomedical	JJ
cord-007726-bqlf72fe	210	8	research	research	NN
cord-007726-bqlf72fe	210	9	using	use	VBG
cord-007726-bqlf72fe	210	10	animals	animal	NNS
cord-007726-bqlf72fe	210	11	is	be	VBZ
cord-007726-bqlf72fe	210	12	the	the	DT
cord-007726-bqlf72fe	210	13	ethics	ethic	NNS
cord-007726-bqlf72fe	210	14	of	of	IN
cord-007726-bqlf72fe	210	15	imposing	impose	VBG
cord-007726-bqlf72fe	210	16	pain	pain	NN
cord-007726-bqlf72fe	210	17	and	and	CC
cord-007726-bqlf72fe	210	18	suffering	suffering	NN
cord-007726-bqlf72fe	210	19	on	on	IN
cord-007726-bqlf72fe	210	20	live	live	JJ
cord-007726-bqlf72fe	210	21	animals	animal	NNS
cord-007726-bqlf72fe	210	22	.	.	.
cord-007726-bqlf72fe	211	1	Although	although	IN
cord-007726-bqlf72fe	211	2	there	there	EX
cord-007726-bqlf72fe	211	3	has	have	VBZ
cord-007726-bqlf72fe	211	4	been	be	VBN
cord-007726-bqlf72fe	211	5	a	a	DT
cord-007726-bqlf72fe	211	6	considerable	considerable	JJ
cord-007726-bqlf72fe	211	7	reduction	reduction	NN
cord-007726-bqlf72fe	211	8	in	in	IN
cord-007726-bqlf72fe	211	9	the	the	DT
cord-007726-bqlf72fe	211	10	numbers	number	NNS
cord-007726-bqlf72fe	211	11	of	of	IN
cord-007726-bqlf72fe	211	12	animals	animal	NNS
cord-007726-bqlf72fe	211	13	used	use	VBN
cord-007726-bqlf72fe	211	14	in	in	IN
cord-007726-bqlf72fe	211	15	research	research	NN
cord-007726-bqlf72fe	211	16	in	in	IN
cord-007726-bqlf72fe	211	17	the	the	DT
cord-007726-bqlf72fe	211	18	last	last	JJ
cord-007726-bqlf72fe	211	19	30	30	CD
cord-007726-bqlf72fe	211	20	years	year	NNS
cord-007726-bqlf72fe	211	21	,	,	,
cord-007726-bqlf72fe	211	22	animal	animal	NN
cord-007726-bqlf72fe	211	23	research	research	NN
cord-007726-bqlf72fe	211	24	remains	remain	VBZ
cord-007726-bqlf72fe	211	25	a	a	DT
cord-007726-bqlf72fe	211	26	vital	vital	JJ
cord-007726-bqlf72fe	211	27	part	part	NN
cord-007726-bqlf72fe	211	28	of	of	IN
cord-007726-bqlf72fe	211	29	biomedical	biomedical	JJ
cord-007726-bqlf72fe	211	30	research	research	NN
cord-007726-bqlf72fe	211	31	.	.	.
cord-007726-bqlf72fe	212	1	However	however	RB
cord-007726-bqlf72fe	212	2	,	,	,
cord-007726-bqlf72fe	212	3	no	no	DT
cord-007726-bqlf72fe	212	4	responsible	responsible	JJ
cord-007726-bqlf72fe	212	5	scientist	scientist	NN
cord-007726-bqlf72fe	212	6	wants	want	VBZ
cord-007726-bqlf72fe	212	7	to	to	TO
cord-007726-bqlf72fe	212	8	cause	cause	VB
cord-007726-bqlf72fe	212	9	unnecessary	unnecessary	JJ
cord-007726-bqlf72fe	212	10	suffering	suffering	NN
cord-007726-bqlf72fe	212	11	in	in	IN
cord-007726-bqlf72fe	212	12	experimental	experimental	JJ
cord-007726-bqlf72fe	212	13	animals	animal	NNS
cord-007726-bqlf72fe	212	14	if	if	IN
cord-007726-bqlf72fe	212	15	it	-PRON-	PRP
cord-007726-bqlf72fe	212	16	can	can	MD
cord-007726-bqlf72fe	212	17	be	be	VB
cord-007726-bqlf72fe	212	18	avoided	avoid	VBN
cord-007726-bqlf72fe	212	19	,	,	,
cord-007726-bqlf72fe	212	20	so	so	IN
cord-007726-bqlf72fe	212	21	scientists	scientist	NNS
cord-007726-bqlf72fe	212	22	have	have	VBP
cord-007726-bqlf72fe	212	23	accepted	accept	VBN
cord-007726-bqlf72fe	212	24	controls	control	NNS
cord-007726-bqlf72fe	212	25	on	on	IN
cord-007726-bqlf72fe	212	26	the	the	DT
cord-007726-bqlf72fe	212	27	use	use	NN
cord-007726-bqlf72fe	212	28	of	of	IN
cord-007726-bqlf72fe	212	29	animals	animal	NNS
cord-007726-bqlf72fe	212	30	for	for	IN
cord-007726-bqlf72fe	212	31	medical	medical	JJ
cord-007726-bqlf72fe	212	32	research	research	NN
cord-007726-bqlf72fe	212	33	.	.	.
cord-007726-bqlf72fe	213	1	In	in	IN
cord-007726-bqlf72fe	213	2	the	the	DT
cord-007726-bqlf72fe	213	3	UK	UK	NNP
cord-007726-bqlf72fe	213	4	,	,	,
cord-007726-bqlf72fe	213	5	this	this	DT
cord-007726-bqlf72fe	213	6	ethical	ethical	JJ
cord-007726-bqlf72fe	213	7	framework	framework	NN
cord-007726-bqlf72fe	213	8	has	have	VBZ
cord-007726-bqlf72fe	213	9	been	be	VBN
cord-007726-bqlf72fe	213	10	enshrined	enshrine	VBN
cord-007726-bqlf72fe	213	11	in	in	IN
cord-007726-bqlf72fe	213	12	law	law	NN
cord-007726-bqlf72fe	213	13	,	,	,
cord-007726-bqlf72fe	213	14	i.e.	i.e.	FW
cord-007726-bqlf72fe	213	15	,	,	,
cord-007726-bqlf72fe	213	16	the	the	DT
cord-007726-bqlf72fe	213	17	Animals	animal	NNS
cord-007726-bqlf72fe	213	18	(	(	-LRB-
cord-007726-bqlf72fe	213	19	Scientific	Scientific	NNP
cord-007726-bqlf72fe	213	20	Procedures	Procedures	NNPS
cord-007726-bqlf72fe	213	21	)	)	-RRB-
cord-007726-bqlf72fe	213	22	Act	Act	NNP
cord-007726-bqlf72fe	213	23	1986	1986	CD
cord-007726-bqlf72fe	213	24	.	.	.
cord-007726-bqlf72fe	214	1	This	this	DT
cord-007726-bqlf72fe	214	2	legislation	legislation	NN
cord-007726-bqlf72fe	214	3	requires	require	VBZ
cord-007726-bqlf72fe	214	4	that	that	IN
cord-007726-bqlf72fe	214	5	applications	application	NNS
cord-007726-bqlf72fe	214	6	for	for	IN
cord-007726-bqlf72fe	214	7	a	a	DT
cord-007726-bqlf72fe	214	8	project	project	NN
cord-007726-bqlf72fe	214	9	license	license	NN
cord-007726-bqlf72fe	214	10	to	to	TO
cord-007726-bqlf72fe	214	11	perform	perform	VB
cord-007726-bqlf72fe	214	12	research	research	NN
cord-007726-bqlf72fe	214	13	involving	involve	VBG
cord-007726-bqlf72fe	214	14	the	the	DT
cord-007726-bqlf72fe	214	15	use	use	NN
cord-007726-bqlf72fe	214	16	of	of	IN
cord-007726-bqlf72fe	214	17	"	"	``
cord-007726-bqlf72fe	214	18	protected	protect	VBN
cord-007726-bqlf72fe	214	19	"	"	''
cord-007726-bqlf72fe	214	20	animals	animal	NNS
cord-007726-bqlf72fe	214	21	(	(	-LRB-
cord-007726-bqlf72fe	214	22	including	include	VBG
cord-007726-bqlf72fe	214	23	all	all	DT
cord-007726-bqlf72fe	214	24	vertebrates	vertebrate	NNS
cord-007726-bqlf72fe	214	25	and	and	CC
cord-007726-bqlf72fe	214	26	cephalopods	cephalopod	NNS
cord-007726-bqlf72fe	214	27	)	)	-RRB-
cord-007726-bqlf72fe	214	28	must	must	MD
cord-007726-bqlf72fe	214	29	be	be	VB
cord-007726-bqlf72fe	214	30	fully	fully	RB
cord-007726-bqlf72fe	214	31	assessed	assess	VBN
cord-007726-bqlf72fe	214	32	with	with	IN
cord-007726-bqlf72fe	214	33	regard	regard	NN
cord-007726-bqlf72fe	214	34	to	to	IN
cord-007726-bqlf72fe	214	35	any	any	DT
cord-007726-bqlf72fe	214	36	harm	harm	NN
cord-007726-bqlf72fe	214	37	imposed	impose	VBN
cord-007726-bqlf72fe	214	38	on	on	IN
cord-007726-bqlf72fe	214	39	the	the	DT
cord-007726-bqlf72fe	214	40	animals	animal	NNS
cord-007726-bqlf72fe	214	41	.	.	.
cord-007726-bqlf72fe	215	1	This	this	DT
cord-007726-bqlf72fe	215	2	involves	involve	VBZ
cord-007726-bqlf72fe	215	3	a	a	DT
cord-007726-bqlf72fe	215	4	detailed	detailed	JJ
cord-007726-bqlf72fe	215	5	examination	examination	NN
cord-007726-bqlf72fe	215	6	of	of	IN
cord-007726-bqlf72fe	215	7	the	the	DT
cord-007726-bqlf72fe	215	8	proposed	propose	VBN
cord-007726-bqlf72fe	215	9	procedures	procedure	NNS
cord-007726-bqlf72fe	215	10	and	and	CC
cord-007726-bqlf72fe	215	11	experiments	experiment	NNS
cord-007726-bqlf72fe	215	12	,	,	,
cord-007726-bqlf72fe	215	13	and	and	CC
cord-007726-bqlf72fe	215	14	the	the	DT
cord-007726-bqlf72fe	215	15	numbers	number	NNS
cord-007726-bqlf72fe	215	16	and	and	CC
cord-007726-bqlf72fe	215	17	types	type	NNS
cord-007726-bqlf72fe	215	18	of	of	IN
cord-007726-bqlf72fe	215	19	animal	animal	NN
cord-007726-bqlf72fe	215	20	used	use	VBN
cord-007726-bqlf72fe	215	21	,	,	,
cord-007726-bqlf72fe	215	22	with	with	IN
cord-007726-bqlf72fe	215	23	robust	robust	JJ
cord-007726-bqlf72fe	215	24	statistical	statistical	JJ
cord-007726-bqlf72fe	215	25	calculations	calculation	NNS
cord-007726-bqlf72fe	215	26	to	to	TO
cord-007726-bqlf72fe	215	27	support	support	VB
cord-007726-bqlf72fe	215	28	these	these	DT
cord-007726-bqlf72fe	215	29	numbers	number	NNS
cord-007726-bqlf72fe	215	30	.	.	.
cord-007726-bqlf72fe	216	1	The	the	DT
cord-007726-bqlf72fe	216	2	planned	planned	JJ
cord-007726-bqlf72fe	216	3	studies	study	NNS
cord-007726-bqlf72fe	216	4	are	be	VBP
cord-007726-bqlf72fe	216	5	then	then	RB
cord-007726-bqlf72fe	216	6	considered	consider	VBN
cord-007726-bqlf72fe	216	7	in	in	IN
cord-007726-bqlf72fe	216	8	light	light	NN
cord-007726-bqlf72fe	216	9	of	of	IN
cord-007726-bqlf72fe	216	10	the	the	DT
cord-007726-bqlf72fe	216	11	potential	potential	JJ
cord-007726-bqlf72fe	216	12	benefits	benefit	NNS
cord-007726-bqlf72fe	216	13	of	of	IN
cord-007726-bqlf72fe	216	14	the	the	DT
cord-007726-bqlf72fe	216	15	project	project	NN
cord-007726-bqlf72fe	216	16	.	.	.
cord-007726-bqlf72fe	217	1	Both	both	CC
cord-007726-bqlf72fe	217	2	within	within	IN
cord-007726-bqlf72fe	217	3	and	and	CC
cord-007726-bqlf72fe	217	4	outside	outside	IN
cord-007726-bqlf72fe	217	5	the	the	DT
cord-007726-bqlf72fe	217	6	UK	UK	NNP
cord-007726-bqlf72fe	217	7	,	,	,
cord-007726-bqlf72fe	217	8	approval	approval	NN
cord-007726-bqlf72fe	217	9	for	for	IN
cord-007726-bqlf72fe	217	10	a	a	DT
cord-007726-bqlf72fe	217	11	study	study	NN
cord-007726-bqlf72fe	217	12	involving	involve	VBG
cord-007726-bqlf72fe	217	13	protected	protect	VBN
cord-007726-bqlf72fe	217	14	animals	animal	NNS
cord-007726-bqlf72fe	217	15	also	also	RB
cord-007726-bqlf72fe	217	16	requires	require	VBZ
cord-007726-bqlf72fe	217	17	an	an	DT
cord-007726-bqlf72fe	217	18	internal	internal	JJ
cord-007726-bqlf72fe	217	19	ethical	ethical	JJ
cord-007726-bqlf72fe	217	20	review	review	NN
cord-007726-bqlf72fe	217	21	process	process	NN
cord-007726-bqlf72fe	217	22	,	,	,
cord-007726-bqlf72fe	217	23	usually	usually	RB
cord-007726-bqlf72fe	217	24	conducted	conduct	VBN
cord-007726-bqlf72fe	217	25	by	by	IN
cord-007726-bqlf72fe	217	26	the	the	DT
cord-007726-bqlf72fe	217	27	research	research	NN
cord-007726-bqlf72fe	217	28	institution	institution	NN
cord-007726-bqlf72fe	217	29	where	where	WRB
cord-007726-bqlf72fe	217	30	the	the	DT
cord-007726-bqlf72fe	217	31	work	work	NN
cord-007726-bqlf72fe	217	32	is	be	VBZ
cord-007726-bqlf72fe	217	33	taking	take	VBG
cord-007726-bqlf72fe	217	34	place	place	NN
cord-007726-bqlf72fe	217	35	,	,	,
cord-007726-bqlf72fe	217	36	with	with	IN
cord-007726-bqlf72fe	217	37	the	the	DT
cord-007726-bqlf72fe	217	38	aim	aim	NN
cord-007726-bqlf72fe	217	39	of	of	IN
cord-007726-bqlf72fe	217	40	promoting	promote	VBG
cord-007726-bqlf72fe	217	41	animal	animal	NN
cord-007726-bqlf72fe	217	42	welfare	welfare	NN
cord-007726-bqlf72fe	217	43	by	by	IN
cord-007726-bqlf72fe	217	44	ensuring	ensure	VBG
cord-007726-bqlf72fe	217	45	the	the	DT
cord-007726-bqlf72fe	217	46	work	work	NN
cord-007726-bqlf72fe	217	47	will	will	MD
cord-007726-bqlf72fe	217	48	be	be	VB
cord-007726-bqlf72fe	217	49	carried	carry	VBN
cord-007726-bqlf72fe	217	50	out	out	RP
cord-007726-bqlf72fe	217	51	in	in	IN
cord-007726-bqlf72fe	217	52	an	an	DT
cord-007726-bqlf72fe	217	53	ethical	ethical	JJ
cord-007726-bqlf72fe	217	54	manner	manner	NN
cord-007726-bqlf72fe	217	55	and	and	CC
cord-007726-bqlf72fe	217	56	that	that	IN
cord-007726-bqlf72fe	217	57	the	the	DT
cord-007726-bqlf72fe	217	58	use	use	NN
cord-007726-bqlf72fe	217	59	of	of	IN
cord-007726-bqlf72fe	217	60	animals	animal	NNS
cord-007726-bqlf72fe	217	61	is	be	VBZ
cord-007726-bqlf72fe	217	62	justified	justify	VBN
cord-007726-bqlf72fe	217	63	.	.	.
cord-007726-bqlf72fe	218	1	Additionally	additionally	RB
cord-007726-bqlf72fe	218	2	,	,	,
cord-007726-bqlf72fe	218	3	the	the	DT
cord-007726-bqlf72fe	218	4	UK	UK	NNP
cord-007726-bqlf72fe	218	5	has	have	VBZ
cord-007726-bqlf72fe	218	6	a	a	DT
cord-007726-bqlf72fe	218	7	national	national	JJ
cord-007726-bqlf72fe	218	8	animal	animal	NN
cord-007726-bqlf72fe	218	9	use	use	NN
cord-007726-bqlf72fe	218	10	reduction	reduction	NN
cord-007726-bqlf72fe	218	11	strategy	strategy	NN
cord-007726-bqlf72fe	218	12	supported	support	VBN
cord-007726-bqlf72fe	218	13	by	by	IN
cord-007726-bqlf72fe	218	14	the	the	DT
cord-007726-bqlf72fe	218	15	National	National	NNP
cord-007726-bqlf72fe	218	16	Centre	Centre	NNP
cord-007726-bqlf72fe	218	17	for	for	IN
cord-007726-bqlf72fe	218	18	the	the	DT
cord-007726-bqlf72fe	218	19	Replacement	Replacement	NNP
cord-007726-bqlf72fe	218	20	,	,	,
cord-007726-bqlf72fe	218	21	Refinement	Refinement	NNP
cord-007726-bqlf72fe	218	22	and	and	CC
cord-007726-bqlf72fe	218	23	Reduction	Reduction	NNP
cord-007726-bqlf72fe	218	24	of	of	IN
cord-007726-bqlf72fe	218	25	Animals	Animals	NNPS
cord-007726-bqlf72fe	218	26	in	in	IN
cord-007726-bqlf72fe	218	27	Research	Research	NNP
cord-007726-bqlf72fe	218	28	(	(	-LRB-
cord-007726-bqlf72fe	218	29	NC3Rs	NC3Rs	NNP
cord-007726-bqlf72fe	218	30	;	;	:
cord-007726-bqlf72fe	218	31	London	London	NNP
cord-007726-bqlf72fe	218	32	,	,	,
cord-007726-bqlf72fe	218	33	UK	UK	NNP
cord-007726-bqlf72fe	218	34	)	)	-RRB-
cord-007726-bqlf72fe	218	35	.	.	.
cord-007726-bqlf72fe	219	1	This	this	DT
cord-007726-bqlf72fe	219	2	consortium	consortium	NN
cord-007726-bqlf72fe	219	3	was	be	VBD
cord-007726-bqlf72fe	219	4	established	establish	VBN
cord-007726-bqlf72fe	219	5	in	in	IN
cord-007726-bqlf72fe	219	6	2004	2004	CD
cord-007726-bqlf72fe	219	7	to	to	TO
cord-007726-bqlf72fe	219	8	promote	promote	VB
cord-007726-bqlf72fe	219	9	and	and	CC
cord-007726-bqlf72fe	219	10	develop	develop	VB
cord-007726-bqlf72fe	219	11	high	high	JJ
cord-007726-bqlf72fe	219	12	-	-	HYPH
cord-007726-bqlf72fe	219	13	quality	quality	NN
cord-007726-bqlf72fe	219	14	research	research	NN
cord-007726-bqlf72fe	219	15	that	that	WDT
cord-007726-bqlf72fe	219	16	takes	take	VBZ
cord-007726-bqlf72fe	219	17	the	the	DT
cord-007726-bqlf72fe	219	18	principles	principle	NNS
cord-007726-bqlf72fe	219	19	of	of	IN
cord-007726-bqlf72fe	219	20	replacement	replacement	NN
cord-007726-bqlf72fe	219	21	,	,	,
cord-007726-bqlf72fe	219	22	refinement	refinement	NN
cord-007726-bqlf72fe	219	23	,	,	,
cord-007726-bqlf72fe	219	24	and	and	CC
cord-007726-bqlf72fe	219	25	reduction	reduction	NN
cord-007726-bqlf72fe	219	26	(	(	-LRB-
cord-007726-bqlf72fe	219	27	the	the	DT
cord-007726-bqlf72fe	219	28	3Rs	3rs	NN
cord-007726-bqlf72fe	219	29	)	)	-RRB-
cord-007726-bqlf72fe	219	30	into	into	IN
cord-007726-bqlf72fe	219	31	account	account	NN
cord-007726-bqlf72fe	219	32	.	.	.
cord-007726-bqlf72fe	220	1	Replacement	replacement	NN
cord-007726-bqlf72fe	220	2	strategies	strategy	NNS
cord-007726-bqlf72fe	220	3	often	often	RB
cord-007726-bqlf72fe	220	4	involve	involve	VBP
cord-007726-bqlf72fe	220	5	the	the	DT
cord-007726-bqlf72fe	220	6	use	use	NN
cord-007726-bqlf72fe	220	7	of	of	IN
cord-007726-bqlf72fe	220	8	alternative	alternative	JJ
cord-007726-bqlf72fe	220	9	,	,	,
cord-007726-bqlf72fe	220	10	non	non	JJ
cord-007726-bqlf72fe	220	11	-	-	JJ
cord-007726-bqlf72fe	220	12	protected	protect	VBN
cord-007726-bqlf72fe	220	13	species	specie	NNS
cord-007726-bqlf72fe	220	14	(	(	-LRB-
cord-007726-bqlf72fe	220	15	e.g.	e.g.	RB
cord-007726-bqlf72fe	220	16	,	,	,
cord-007726-bqlf72fe	220	17	zebrafish	zebrafish	NN
cord-007726-bqlf72fe	220	18	,	,	,
cord-007726-bqlf72fe	220	19	fruit	fruit	NN
cord-007726-bqlf72fe	220	20	flies	fly	NNS
cord-007726-bqlf72fe	220	21	,	,	,
cord-007726-bqlf72fe	220	22	flatworms	flatworm	NNS
cord-007726-bqlf72fe	220	23	)	)	-RRB-
cord-007726-bqlf72fe	220	24	and	and	CC
cord-007726-bqlf72fe	220	25	in	in	IN
cord-007726-bqlf72fe	220	26	vitro	vitro	FW
cord-007726-bqlf72fe	220	27	correlates	correlate	VBZ
cord-007726-bqlf72fe	220	28	(	(	-LRB-
cord-007726-bqlf72fe	220	29	two	two	CD
cord-007726-bqlf72fe	220	30	-	-	HYPH
cord-007726-bqlf72fe	220	31	dimensional	dimensional	JJ
cord-007726-bqlf72fe	220	32	cell	cell	NN
cord-007726-bqlf72fe	220	33	culture	culture	NN
cord-007726-bqlf72fe	220	34	or	or	CC
cord-007726-bqlf72fe	220	35	threedimensional	threedimensional	JJ
cord-007726-bqlf72fe	220	36	organoids	organoid	NNS
cord-007726-bqlf72fe	220	37	containing	contain	VBG
cord-007726-bqlf72fe	220	38	multiple	multiple	JJ
cord-007726-bqlf72fe	220	39	cell	cell	NN
cord-007726-bqlf72fe	220	40	types	type	NNS
cord-007726-bqlf72fe	220	41	)	)	-RRB-
cord-007726-bqlf72fe	220	42	to	to	TO
cord-007726-bqlf72fe	220	43	test	test	VB
cord-007726-bqlf72fe	220	44	hypotheses	hypothesis	NNS
cord-007726-bqlf72fe	220	45	and	and	CC
cord-007726-bqlf72fe	220	46	assess	assess	VB
cord-007726-bqlf72fe	220	47	the	the	DT
cord-007726-bqlf72fe	220	48	effects	effect	NNS
cord-007726-bqlf72fe	220	49	of	of	IN
cord-007726-bqlf72fe	220	50	therapeutic	therapeutic	JJ
cord-007726-bqlf72fe	220	51	interventions	intervention	NNS
cord-007726-bqlf72fe	220	52	.	.	.
cord-007726-bqlf72fe	221	1	The	the	DT
cord-007726-bqlf72fe	221	2	main	main	JJ
cord-007726-bqlf72fe	221	3	obstacle	obstacle	NN
cord-007726-bqlf72fe	221	4	with	with	IN
cord-007726-bqlf72fe	221	5	studies	study	NNS
cord-007726-bqlf72fe	221	6	on	on	IN
cord-007726-bqlf72fe	221	7	non	non	JJ
cord-007726-bqlf72fe	221	8	-	-	JJ
cord-007726-bqlf72fe	221	9	protected	protected	JJ
cord-007726-bqlf72fe	221	10	animals	animal	NNS
cord-007726-bqlf72fe	221	11	is	be	VBZ
cord-007726-bqlf72fe	221	12	the	the	DT
cord-007726-bqlf72fe	221	13	difficulty	difficulty	NN
cord-007726-bqlf72fe	221	14	of	of	IN
cord-007726-bqlf72fe	221	15	accurately	accurately	RB
cord-007726-bqlf72fe	221	16	mimicking	mimic	VBG
cord-007726-bqlf72fe	221	17	the	the	DT
cord-007726-bqlf72fe	221	18	complex	complex	JJ
cord-007726-bqlf72fe	221	19	physiological	physiological	JJ
cord-007726-bqlf72fe	221	20	systems	system	NNS
cord-007726-bqlf72fe	221	21	involved	involve	VBN
cord-007726-bqlf72fe	221	22	in	in	IN
cord-007726-bqlf72fe	221	23	human	human	JJ
cord-007726-bqlf72fe	221	24	health	health	NN
cord-007726-bqlf72fe	221	25	and	and	CC
cord-007726-bqlf72fe	221	26	disease	disease	NN
cord-007726-bqlf72fe	221	27	,	,	,
cord-007726-bqlf72fe	221	28	as	as	IN
cord-007726-bqlf72fe	221	29	described	describe	VBN
cord-007726-bqlf72fe	221	30	in	in	IN
cord-007726-bqlf72fe	221	31	detail	detail	NN
cord-007726-bqlf72fe	221	32	above	above	RB
cord-007726-bqlf72fe	221	33	.	.	.
cord-007726-bqlf72fe	222	1	For	for	IN
cord-007726-bqlf72fe	222	2	example	example	NN
cord-007726-bqlf72fe	222	3	,	,	,
cord-007726-bqlf72fe	222	4	the	the	DT
cord-007726-bqlf72fe	222	5	fruit	fruit	NN
cord-007726-bqlf72fe	222	6	fly	fly	VBP
cord-007726-bqlf72fe	222	7	Drosophila	Drosophila	NNP
cord-007726-bqlf72fe	222	8	melanogaster	melanogaster	NN
cord-007726-bqlf72fe	222	9	is	be	VBZ
cord-007726-bqlf72fe	222	10	an	an	DT
cord-007726-bqlf72fe	222	11	excellent	excellent	JJ
cord-007726-bqlf72fe	222	12	model	model	NN
cord-007726-bqlf72fe	222	13	organism	organism	NN
cord-007726-bqlf72fe	222	14	for	for	IN
cord-007726-bqlf72fe	222	15	studies	study	NNS
cord-007726-bqlf72fe	222	16	on	on	IN
cord-007726-bqlf72fe	222	17	genetic	genetic	JJ
cord-007726-bqlf72fe	222	18	diseases	disease	NNS
cord-007726-bqlf72fe	222	19	,	,	,
cord-007726-bqlf72fe	222	20	aging	age	VBG
cord-007726-bqlf72fe	222	21	,	,	,
cord-007726-bqlf72fe	222	22	and	and	CC
cord-007726-bqlf72fe	222	23	pathogen	pathogen	NN
cord-007726-bqlf72fe	222	24	-	-	HYPH
cord-007726-bqlf72fe	222	25	borne	bear	VBN
cord-007726-bqlf72fe	222	26	illnesses	illness	NNS
cord-007726-bqlf72fe	222	27	but	but	CC
cord-007726-bqlf72fe	222	28	may	may	MD
cord-007726-bqlf72fe	222	29	be	be	VB
cord-007726-bqlf72fe	222	30	less	less	RBR
cord-007726-bqlf72fe	222	31	relevant	relevant	JJ
cord-007726-bqlf72fe	222	32	for	for	IN
cord-007726-bqlf72fe	222	33	studies	study	NNS
cord-007726-bqlf72fe	222	34	on	on	IN
cord-007726-bqlf72fe	222	35	complex	complex	JJ
cord-007726-bqlf72fe	222	36	lung	lung	NN
cord-007726-bqlf72fe	222	37	diseases	disease	NNS
cord-007726-bqlf72fe	222	38	.	.	.
cord-007726-bqlf72fe	223	1	Importantly	importantly	RB
cord-007726-bqlf72fe	223	2	,	,	,
cord-007726-bqlf72fe	223	3	model	model	NN
cord-007726-bqlf72fe	223	4	organisms	organism	NNS
cord-007726-bqlf72fe	223	5	such	such	JJ
cord-007726-bqlf72fe	223	6	as	as	IN
cord-007726-bqlf72fe	223	7	fruit	fruit	NN
cord-007726-bqlf72fe	223	8	flies	fly	NNS
cord-007726-bqlf72fe	223	9	,	,	,
cord-007726-bqlf72fe	223	10	zebrafish	zebrafish	NN
cord-007726-bqlf72fe	223	11	,	,	,
cord-007726-bqlf72fe	223	12	and	and	CC
cord-007726-bqlf72fe	223	13	flatworms	flatworm	NNS
cord-007726-bqlf72fe	223	14	do	do	VBP
cord-007726-bqlf72fe	223	15	not	not	RB
cord-007726-bqlf72fe	223	16	possess	possess	VB
cord-007726-bqlf72fe	223	17	lungs	lung	NNS
cord-007726-bqlf72fe	223	18	,	,	,
cord-007726-bqlf72fe	223	19	which	which	WDT
cord-007726-bqlf72fe	223	20	somewhat	somewhat	RB
cord-007726-bqlf72fe	223	21	limits	limit	VBZ
cord-007726-bqlf72fe	223	22	the	the	DT
cord-007726-bqlf72fe	223	23	translatability	translatability	NN
cord-007726-bqlf72fe	223	24	of	of	IN
cord-007726-bqlf72fe	223	25	research	research	NN
cord-007726-bqlf72fe	223	26	on	on	IN
cord-007726-bqlf72fe	223	27	these	these	DT
cord-007726-bqlf72fe	223	28	animals	animal	NNS
cord-007726-bqlf72fe	223	29	in	in	IN
cord-007726-bqlf72fe	223	30	the	the	DT
cord-007726-bqlf72fe	223	31	field	field	NN
cord-007726-bqlf72fe	223	32	of	of	IN
cord-007726-bqlf72fe	223	33	respiratory	respiratory	JJ
cord-007726-bqlf72fe	223	34	disease	disease	NN
cord-007726-bqlf72fe	223	35	.	.	.
cord-007726-bqlf72fe	224	1	As	as	IN
cord-007726-bqlf72fe	224	2	such	such	JJ
cord-007726-bqlf72fe	224	3	,	,	,
cord-007726-bqlf72fe	224	4	it	-PRON-	PRP
cord-007726-bqlf72fe	224	5	is	be	VBZ
cord-007726-bqlf72fe	224	6	likely	likely	JJ
cord-007726-bqlf72fe	224	7	that	that	IN
cord-007726-bqlf72fe	224	8	rodents	rodent	NNS
cord-007726-bqlf72fe	224	9	will	will	MD
cord-007726-bqlf72fe	224	10	remain	remain	VB
cord-007726-bqlf72fe	224	11	the	the	DT
cord-007726-bqlf72fe	224	12	model	model	NN
cord-007726-bqlf72fe	224	13	organism	organism	NN
cord-007726-bqlf72fe	224	14	of	of	IN
cord-007726-bqlf72fe	224	15	choice	choice	NN
cord-007726-bqlf72fe	224	16	for	for	IN
cord-007726-bqlf72fe	224	17	studies	study	NNS
cord-007726-bqlf72fe	224	18	into	into	IN
cord-007726-bqlf72fe	224	19	lung	lung	NN
cord-007726-bqlf72fe	224	20	disease	disease	NN
cord-007726-bqlf72fe	224	21	for	for	IN
cord-007726-bqlf72fe	224	22	some	some	DT
cord-007726-bqlf72fe	224	23	time	time	NN
cord-007726-bqlf72fe	224	24	to	to	TO
cord-007726-bqlf72fe	224	25	come	come	VB
cord-007726-bqlf72fe	224	26	.	.	.
cord-007726-bqlf72fe	225	1	There	there	EX
cord-007726-bqlf72fe	225	2	has	have	VBZ
cord-007726-bqlf72fe	225	3	been	be	VBN
cord-007726-bqlf72fe	225	4	considerable	considerable	JJ
cord-007726-bqlf72fe	225	5	progress	progress	NN
cord-007726-bqlf72fe	225	6	recently	recently	RB
cord-007726-bqlf72fe	225	7	in	in	IN
cord-007726-bqlf72fe	225	8	imitating	imitate	VBG
cord-007726-bqlf72fe	225	9	single	single	JJ
cord-007726-bqlf72fe	225	10	organs	organ	NNS
cord-007726-bqlf72fe	225	11	such	such	JJ
cord-007726-bqlf72fe	225	12	as	as	IN
cord-007726-bqlf72fe	225	13	the	the	DT
cord-007726-bqlf72fe	225	14	liver	liver	NN
cord-007726-bqlf72fe	225	15	,	,	,
cord-007726-bqlf72fe	225	16	lung	lung	NN
cord-007726-bqlf72fe	225	17	,	,	,
cord-007726-bqlf72fe	225	18	and	and	CC
cord-007726-bqlf72fe	225	19	brain	brain	NN
cord-007726-bqlf72fe	225	20	in	in	IN
cord-007726-bqlf72fe	225	21	vitro	vitro	FW
cord-007726-bqlf72fe	225	22	using	use	VBG
cord-007726-bqlf72fe	225	23	multiple	multiple	JJ
cord-007726-bqlf72fe	225	24	cell	cell	NN
cord-007726-bqlf72fe	225	25	types	type	NNS
cord-007726-bqlf72fe	225	26	and	and	CC
cord-007726-bqlf72fe	225	27	a	a	DT
cord-007726-bqlf72fe	225	28	physical	physical	JJ
cord-007726-bqlf72fe	225	29	scaffold	scaffold	NN
cord-007726-bqlf72fe	225	30	.	.	.
cord-007726-bqlf72fe	226	1	As	as	IN
cord-007726-bqlf72fe	226	2	an	an	DT
cord-007726-bqlf72fe	226	3	important	important	JJ
cord-007726-bqlf72fe	226	4	advantage	advantage	NN
cord-007726-bqlf72fe	226	5	,	,	,
cord-007726-bqlf72fe	226	6	these	these	DT
cord-007726-bqlf72fe	226	7	in	in	IN
cord-007726-bqlf72fe	226	8	vitro	vitro	FW
cord-007726-bqlf72fe	226	9	tests	test	NNS
cord-007726-bqlf72fe	226	10	have	have	VBP
cord-007726-bqlf72fe	226	11	replaced	replace	VBN
cord-007726-bqlf72fe	226	12	a	a	DT
cord-007726-bqlf72fe	226	13	large	large	JJ
cord-007726-bqlf72fe	226	14	number	number	NN
cord-007726-bqlf72fe	226	15	of	of	IN
cord-007726-bqlf72fe	226	16	rodents	rodent	NNS
cord-007726-bqlf72fe	226	17	in	in	IN
cord-007726-bqlf72fe	226	18	initial	initial	JJ
cord-007726-bqlf72fe	226	19	drug	drug	NN
cord-007726-bqlf72fe	226	20	discovery	discovery	NN
cord-007726-bqlf72fe	226	21	experiments	experiment	NNS
cord-007726-bqlf72fe	226	22	,	,	,
cord-007726-bqlf72fe	226	23	while	while	IN
cord-007726-bqlf72fe	226	24	also	also	RB
cord-007726-bqlf72fe	226	25	speeding	speed	VBG
cord-007726-bqlf72fe	226	26	up	up	RP
cord-007726-bqlf72fe	226	27	the	the	DT
cord-007726-bqlf72fe	226	28	process	process	NN
cord-007726-bqlf72fe	226	29	[	[	-LRB-
cord-007726-bqlf72fe	226	30	64	64	CD
cord-007726-bqlf72fe	226	31	]	]	-RRB-
cord-007726-bqlf72fe	226	32	.	.	.
cord-007726-bqlf72fe	227	1	These	these	DT
cord-007726-bqlf72fe	227	2	studies	study	NNS
cord-007726-bqlf72fe	227	3	still	still	RB
cord-007726-bqlf72fe	227	4	require	require	VBP
cord-007726-bqlf72fe	227	5	further	further	JJ
cord-007726-bqlf72fe	227	6	refinement	refinement	NN
cord-007726-bqlf72fe	227	7	and	and	CC
cord-007726-bqlf72fe	227	8	validation	validation	NN
cord-007726-bqlf72fe	227	9	to	to	TO
cord-007726-bqlf72fe	227	10	establish	establish	VB
cord-007726-bqlf72fe	227	11	them	-PRON-	PRP
cord-007726-bqlf72fe	227	12	as	as	IN
cord-007726-bqlf72fe	227	13	suitable	suitable	JJ
cord-007726-bqlf72fe	227	14	models	model	NNS
cord-007726-bqlf72fe	227	15	for	for	IN
cord-007726-bqlf72fe	227	16	an	an	DT
cord-007726-bqlf72fe	227	17	entire	entire	JJ
cord-007726-bqlf72fe	227	18	organ	organ	NN
cord-007726-bqlf72fe	227	19	;	;	:
cord-007726-bqlf72fe	227	20	importantly	importantly	RB
cord-007726-bqlf72fe	227	21	,	,	,
cord-007726-bqlf72fe	227	22	these	these	DT
cord-007726-bqlf72fe	227	23	in	in	IN
cord-007726-bqlf72fe	227	24	vitro	vitro	FW
cord-007726-bqlf72fe	227	25	organoids	organoids	NNP
cord-007726-bqlf72fe	227	26	can	can	MD
cord-007726-bqlf72fe	227	27	not	not	RB
cord-007726-bqlf72fe	227	28	take	take	VB
cord-007726-bqlf72fe	227	29	into	into	IN
cord-007726-bqlf72fe	227	30	account	account	NN
cord-007726-bqlf72fe	227	31	interactions	interaction	NNS
cord-007726-bqlf72fe	227	32	between	between	IN
cord-007726-bqlf72fe	227	33	organ	organ	NN
cord-007726-bqlf72fe	227	34	systems	system	NNS
cord-007726-bqlf72fe	227	35	in	in	IN
cord-007726-bqlf72fe	227	36	complex	complex	JJ
cord-007726-bqlf72fe	227	37	,	,	,
cord-007726-bqlf72fe	227	38	multisystem	multisystem	JJ
cord-007726-bqlf72fe	227	39	diseases	disease	NNS
cord-007726-bqlf72fe	227	40	such	such	JJ
cord-007726-bqlf72fe	227	41	as	as	IN
cord-007726-bqlf72fe	227	42	COPD	COPD	NNP
cord-007726-bqlf72fe	227	43	.	.	.
cord-007726-bqlf72fe	228	1	Refinement	refinement	NN
cord-007726-bqlf72fe	228	2	involves	involve	VBZ
cord-007726-bqlf72fe	228	3	selecting	select	VBG
cord-007726-bqlf72fe	228	4	the	the	DT
cord-007726-bqlf72fe	228	5	most	most	RBS
cord-007726-bqlf72fe	228	6	clinically	clinically	RB
cord-007726-bqlf72fe	228	7	relevant	relevant	JJ
cord-007726-bqlf72fe	228	8	model	model	NN
cord-007726-bqlf72fe	228	9	for	for	IN
cord-007726-bqlf72fe	228	10	the	the	DT
cord-007726-bqlf72fe	228	11	disease	disease	NN
cord-007726-bqlf72fe	228	12	available	available	JJ
cord-007726-bqlf72fe	228	13	,	,	,
cord-007726-bqlf72fe	228	14	informed	inform	VBN
cord-007726-bqlf72fe	228	15	by	by	IN
cord-007726-bqlf72fe	228	16	the	the	DT
cord-007726-bqlf72fe	228	17	discussion	discussion	NN
cord-007726-bqlf72fe	228	18	above	above	IN
cord-007726-bqlf72fe	228	19	on	on	IN
cord-007726-bqlf72fe	228	20	closely	closely	RB
cord-007726-bqlf72fe	228	21	recapitulating	recapitulate	VBG
cord-007726-bqlf72fe	228	22	the	the	DT
cord-007726-bqlf72fe	228	23	etiologic	etiologic	JJ
cord-007726-bqlf72fe	228	24	agent	agent	NN
cord-007726-bqlf72fe	228	25	and	and	CC
cord-007726-bqlf72fe	228	26	disease	disease	NNP
cord-007726-bqlf72fe	228	27	pathobiology	pathobiology	NN
cord-007726-bqlf72fe	228	28	associated	associate	VBN
cord-007726-bqlf72fe	228	29	with	with	IN
cord-007726-bqlf72fe	228	30	clinical	clinical	JJ
cord-007726-bqlf72fe	228	31	cases	case	NNS
cord-007726-bqlf72fe	228	32	.	.	.
cord-007726-bqlf72fe	229	1	Another	another	DT
cord-007726-bqlf72fe	229	2	important	important	JJ
cord-007726-bqlf72fe	229	3	factor	factor	NN
cord-007726-bqlf72fe	229	4	is	be	VBZ
cord-007726-bqlf72fe	229	5	refining	refine	VBG
cord-007726-bqlf72fe	229	6	the	the	DT
cord-007726-bqlf72fe	229	7	management	management	NN
cord-007726-bqlf72fe	229	8	of	of	IN
cord-007726-bqlf72fe	229	9	pain	pain	NN
cord-007726-bqlf72fe	229	10	.	.	.
cord-007726-bqlf72fe	230	1	An	an	DT
cord-007726-bqlf72fe	230	2	assessment	assessment	NN
cord-007726-bqlf72fe	230	3	of	of	IN
cord-007726-bqlf72fe	230	4	the	the	DT
cord-007726-bqlf72fe	230	5	procedures	procedure	NNS
cord-007726-bqlf72fe	230	6	used	use	VBN
cord-007726-bqlf72fe	230	7	and	and	CC
cord-007726-bqlf72fe	230	8	the	the	DT
cord-007726-bqlf72fe	230	9	effects	effect	NNS
cord-007726-bqlf72fe	230	10	of	of	IN
cord-007726-bqlf72fe	230	11	the	the	DT
cord-007726-bqlf72fe	230	12	substance	substance	NN
cord-007726-bqlf72fe	230	13	on	on	IN
cord-007726-bqlf72fe	230	14	the	the	DT
cord-007726-bqlf72fe	230	15	animal	animal	NN
cord-007726-bqlf72fe	230	16	,	,	,
cord-007726-bqlf72fe	230	17	as	as	RB
cord-007726-bqlf72fe	230	18	well	well	RB
cord-007726-bqlf72fe	230	19	as	as	IN
cord-007726-bqlf72fe	230	20	the	the	DT
cord-007726-bqlf72fe	230	21	degree	degree	NN
cord-007726-bqlf72fe	230	22	of	of	IN
cord-007726-bqlf72fe	230	23	handling	handling	NN
cord-007726-bqlf72fe	230	24	,	,	,
cord-007726-bqlf72fe	230	25	restraint	restraint	NN
cord-007726-bqlf72fe	230	26	,	,	,
cord-007726-bqlf72fe	230	27	and	and	CC
cord-007726-bqlf72fe	230	28	analgesia	analgesia	NN
cord-007726-bqlf72fe	230	29	,	,	,
cord-007726-bqlf72fe	230	30	are	be	VBP
cord-007726-bqlf72fe	230	31	other	other	JJ
cord-007726-bqlf72fe	230	32	important	important	JJ
cord-007726-bqlf72fe	230	33	aspects	aspect	NNS
cord-007726-bqlf72fe	230	34	of	of	IN
cord-007726-bqlf72fe	230	35	refinement	refinement	NN
cord-007726-bqlf72fe	230	36	.	.	.
cord-007726-bqlf72fe	231	1	This	this	DT
cord-007726-bqlf72fe	231	2	standard	standard	NN
cord-007726-bqlf72fe	231	3	of	of	IN
cord-007726-bqlf72fe	231	4	animal	animal	NN
cord-007726-bqlf72fe	231	5	care	care	NN
cord-007726-bqlf72fe	231	6	is	be	VBZ
cord-007726-bqlf72fe	231	7	achieved	achieve	VBN
cord-007726-bqlf72fe	231	8	through	through	IN
cord-007726-bqlf72fe	231	9	strict	strict	JJ
cord-007726-bqlf72fe	231	10	regulations	regulation	NNS
cord-007726-bqlf72fe	231	11	and	and	CC
cord-007726-bqlf72fe	231	12	controls	control	NNS
cord-007726-bqlf72fe	231	13	on	on	IN
cord-007726-bqlf72fe	231	14	how	how	WRB
cord-007726-bqlf72fe	231	15	personnel	personnel	NNS
cord-007726-bqlf72fe	231	16	are	be	VBP
cord-007726-bqlf72fe	231	17	trained	train	VBN
cord-007726-bqlf72fe	231	18	to	to	TO
cord-007726-bqlf72fe	231	19	carry	carry	VB
cord-007726-bqlf72fe	231	20	out	out	RP
cord-007726-bqlf72fe	231	21	experiments	experiment	NNS
cord-007726-bqlf72fe	231	22	on	on	IN
cord-007726-bqlf72fe	231	23	live	live	JJ
cord-007726-bqlf72fe	231	24	animals	animal	NNS
cord-007726-bqlf72fe	231	25	.	.	.
cord-007726-bqlf72fe	232	1	Adequate	adequate	JJ
cord-007726-bqlf72fe	232	2	training	training	NN
cord-007726-bqlf72fe	232	3	is	be	VBZ
cord-007726-bqlf72fe	232	4	an	an	DT
cord-007726-bqlf72fe	232	5	important	important	JJ
cord-007726-bqlf72fe	232	6	aspect	aspect	NN
cord-007726-bqlf72fe	232	7	of	of	IN
cord-007726-bqlf72fe	232	8	refinement	refinement	NN
cord-007726-bqlf72fe	232	9	and	and	CC
cord-007726-bqlf72fe	232	10	should	should	MD
cord-007726-bqlf72fe	232	11	be	be	VB
cord-007726-bqlf72fe	232	12	reviewed	review	VBN
cord-007726-bqlf72fe	232	13	and	and	CC
cord-007726-bqlf72fe	232	14	improved	improve	VBN
cord-007726-bqlf72fe	232	15	on	on	IN
cord-007726-bqlf72fe	232	16	an	an	DT
cord-007726-bqlf72fe	232	17	ongoing	ongoing	JJ
cord-007726-bqlf72fe	232	18	basis	basis	NN
cord-007726-bqlf72fe	232	19	.	.	.
cord-007726-bqlf72fe	233	1	Moreover	moreover	RB
cord-007726-bqlf72fe	233	2	,	,	,
cord-007726-bqlf72fe	233	3	refinement	refinement	NN
cord-007726-bqlf72fe	233	4	can	can	MD
cord-007726-bqlf72fe	233	5	be	be	VB
cord-007726-bqlf72fe	233	6	achieved	achieve	VBN
cord-007726-bqlf72fe	233	7	by	by	IN
cord-007726-bqlf72fe	233	8	improving	improve	VBG
cord-007726-bqlf72fe	233	9	animal	animal	NN
cord-007726-bqlf72fe	233	10	housing	housing	NN
cord-007726-bqlf72fe	233	11	by	by	IN
cord-007726-bqlf72fe	233	12	environmental	environmental	JJ
cord-007726-bqlf72fe	233	13	enrichment	enrichment	NN
cord-007726-bqlf72fe	233	14	,	,	,
cord-007726-bqlf72fe	233	15	e.g.	e.g.	RB
cord-007726-bqlf72fe	233	16	,	,	,
cord-007726-bqlf72fe	233	17	providing	provide	VBG
cord-007726-bqlf72fe	233	18	a	a	DT
cord-007726-bqlf72fe	233	19	place	place	NN
cord-007726-bqlf72fe	233	20	for	for	IN
cord-007726-bqlf72fe	233	21	mice	mouse	NNS
cord-007726-bqlf72fe	233	22	to	to	TO
cord-007726-bqlf72fe	233	23	hide	hide	VB
cord-007726-bqlf72fe	233	24	in	in	IN
cord-007726-bqlf72fe	233	25	the	the	DT
cord-007726-bqlf72fe	233	26	cage	cage	NN
cord-007726-bqlf72fe	233	27	and	and	CC
cord-007726-bqlf72fe	233	28	housing	housing	NN
cord-007726-bqlf72fe	233	29	social	social	JJ
cord-007726-bqlf72fe	233	30	animals	animal	NNS
cord-007726-bqlf72fe	233	31	such	such	JJ
cord-007726-bqlf72fe	233	32	as	as	IN
cord-007726-bqlf72fe	233	33	mice	mouse	NNS
cord-007726-bqlf72fe	233	34	in	in	IN
cord-007726-bqlf72fe	233	35	appropriate	appropriate	JJ
cord-007726-bqlf72fe	233	36	-	-	HYPH
cord-007726-bqlf72fe	233	37	sized	sized	JJ
cord-007726-bqlf72fe	233	38	groups	group	NNS
cord-007726-bqlf72fe	233	39	.	.	.
cord-007726-bqlf72fe	234	1	These	these	DT
cord-007726-bqlf72fe	234	2	simple	simple	JJ
cord-007726-bqlf72fe	234	3	changes	change	NNS
cord-007726-bqlf72fe	234	4	can	can	MD
cord-007726-bqlf72fe	234	5	improve	improve	VB
cord-007726-bqlf72fe	234	6	the	the	DT
cord-007726-bqlf72fe	234	7	physiological	physiological	JJ
cord-007726-bqlf72fe	234	8	and	and	CC
cord-007726-bqlf72fe	234	9	behavioral	behavioral	JJ
cord-007726-bqlf72fe	234	10	status	status	NN
cord-007726-bqlf72fe	234	11	of	of	IN
cord-007726-bqlf72fe	234	12	research	research	NN
cord-007726-bqlf72fe	234	13	animals	animal	NNS
cord-007726-bqlf72fe	234	14	;	;	:
cord-007726-bqlf72fe	234	15	this	this	DT
cord-007726-bqlf72fe	234	16	not	not	RB
cord-007726-bqlf72fe	234	17	only	only	RB
cord-007726-bqlf72fe	234	18	increases	increase	VBZ
cord-007726-bqlf72fe	234	19	animal	animal	NN
cord-007726-bqlf72fe	234	20	well	well	RB
cord-007726-bqlf72fe	234	21	-	-	HYPH
cord-007726-bqlf72fe	234	22	being	be	VBG
cord-007726-bqlf72fe	234	23	but	but	CC
cord-007726-bqlf72fe	234	24	also	also	RB
cord-007726-bqlf72fe	234	25	contributes	contribute	VBZ
cord-007726-bqlf72fe	234	26	to	to	IN
cord-007726-bqlf72fe	234	27	the	the	DT
cord-007726-bqlf72fe	234	28	quality	quality	NN
cord-007726-bqlf72fe	234	29	of	of	IN
cord-007726-bqlf72fe	234	30	the	the	DT
cord-007726-bqlf72fe	234	31	experimental	experimental	JJ
cord-007726-bqlf72fe	234	32	results	result	NNS
cord-007726-bqlf72fe	234	33	by	by	IN
cord-007726-bqlf72fe	234	34	reducing	reduce	VBG
cord-007726-bqlf72fe	234	35	stress	stress	NN
cord-007726-bqlf72fe	234	36	levels	level	NNS
cord-007726-bqlf72fe	234	37	.	.	.
cord-007726-bqlf72fe	235	1	The	the	DT
cord-007726-bqlf72fe	235	2	3Rs	3rs	JJ
cord-007726-bqlf72fe	235	3	aspect	aspect	NN
cord-007726-bqlf72fe	235	4	of	of	IN
cord-007726-bqlf72fe	235	5	reduction	reduction	NN
cord-007726-bqlf72fe	235	6	focuses	focus	VBZ
cord-007726-bqlf72fe	235	7	on	on	IN
cord-007726-bqlf72fe	235	8	the	the	DT
cord-007726-bqlf72fe	235	9	statistical	statistical	JJ
cord-007726-bqlf72fe	235	10	power	power	NN
cord-007726-bqlf72fe	235	11	of	of	IN
cord-007726-bqlf72fe	235	12	experiments	experiment	NNS
cord-007726-bqlf72fe	235	13	and	and	CC
cord-007726-bqlf72fe	235	14	by	by	IN
cord-007726-bqlf72fe	235	15	following	follow	VBG
cord-007726-bqlf72fe	235	16	the	the	DT
cord-007726-bqlf72fe	235	17	Animal	Animal	NNP
cord-007726-bqlf72fe	235	18	Research	Research	NNP
cord-007726-bqlf72fe	235	19	:	:	:
cord-007726-bqlf72fe	235	20	Reporting	reporting	NN
cord-007726-bqlf72fe	235	21	of	of	IN
cord-007726-bqlf72fe	235	22	In	in	IN
cord-007726-bqlf72fe	235	23	Vivo	Vivo	NNP
cord-007726-bqlf72fe	235	24	Experiments	experiment	NNS
cord-007726-bqlf72fe	235	25	(	(	-LRB-
cord-007726-bqlf72fe	235	26	ARRIVE	arrive	NN
cord-007726-bqlf72fe	235	27	)	)	-RRB-
cord-007726-bqlf72fe	235	28	guidelines	guideline	NNS
cord-007726-bqlf72fe	235	29	,	,	,
cord-007726-bqlf72fe	235	30	originally	originally	RB
cord-007726-bqlf72fe	235	31	published	publish	VBN
cord-007726-bqlf72fe	235	32	in	in	IN
cord-007726-bqlf72fe	235	33	PLOS	PLOS	NNP
cord-007726-bqlf72fe	235	34	Biology	Biology	NNP
cord-007726-bqlf72fe	235	35	in	in	IN
cord-007726-bqlf72fe	235	36	2010	2010	CD
cord-007726-bqlf72fe	235	37	.	.	.
cord-007726-bqlf72fe	236	1	These	these	DT
cord-007726-bqlf72fe	236	2	guidelines	guideline	NNS
cord-007726-bqlf72fe	236	3	provide	provide	VBP
cord-007726-bqlf72fe	236	4	a	a	DT
cord-007726-bqlf72fe	236	5	framework	framework	NN
cord-007726-bqlf72fe	236	6	to	to	TO
cord-007726-bqlf72fe	236	7	improve	improve	VB
cord-007726-bqlf72fe	236	8	the	the	DT
cord-007726-bqlf72fe	236	9	reporting	reporting	NN
cord-007726-bqlf72fe	236	10	of	of	IN
cord-007726-bqlf72fe	236	11	research	research	NN
cord-007726-bqlf72fe	236	12	performed	perform	VBN
cord-007726-bqlf72fe	236	13	on	on	IN
cord-007726-bqlf72fe	236	14	live	live	JJ
cord-007726-bqlf72fe	236	15	animals	animal	NNS
cord-007726-bqlf72fe	236	16	by	by	IN
cord-007726-bqlf72fe	236	17	maximizing	maximize	VBG
cord-007726-bqlf72fe	236	18	the	the	DT
cord-007726-bqlf72fe	236	19	quality	quality	NN
cord-007726-bqlf72fe	236	20	of	of	IN
cord-007726-bqlf72fe	236	21	the	the	DT
cord-007726-bqlf72fe	236	22	scientific	scientific	JJ
cord-007726-bqlf72fe	236	23	data	datum	NNS
cord-007726-bqlf72fe	236	24	and	and	CC
cord-007726-bqlf72fe	236	25	by	by	IN
cord-007726-bqlf72fe	236	26	minimizing	minimize	VBG
cord-007726-bqlf72fe	236	27	unnecessary	unnecessary	JJ
cord-007726-bqlf72fe	236	28	studies	study	NNS
cord-007726-bqlf72fe	236	29	.	.	.
cord-007726-bqlf72fe	237	1	The	the	DT
cord-007726-bqlf72fe	237	2	ARRIVE	ARRIVE	NNP
cord-007726-bqlf72fe	237	3	guidelines	guideline	NNS
cord-007726-bqlf72fe	237	4	provide	provide	VBP
cord-007726-bqlf72fe	237	5	a	a	DT
cord-007726-bqlf72fe	237	6	checklist	checklist	NN
cord-007726-bqlf72fe	237	7	of	of	IN
cord-007726-bqlf72fe	237	8	aspects	aspect	NNS
cord-007726-bqlf72fe	237	9	that	that	WDT
cord-007726-bqlf72fe	237	10	must	must	MD
cord-007726-bqlf72fe	237	11	be	be	VB
cord-007726-bqlf72fe	237	12	considered	consider	VBN
cord-007726-bqlf72fe	237	13	in	in	IN
cord-007726-bqlf72fe	237	14	good	good	JJ
cord-007726-bqlf72fe	237	15	quality	quality	NN
cord-007726-bqlf72fe	237	16	research	research	NN
cord-007726-bqlf72fe	237	17	using	use	VBG
cord-007726-bqlf72fe	237	18	live	live	JJ
cord-007726-bqlf72fe	237	19	animals	animal	NNS
cord-007726-bqlf72fe	237	20	.	.	.
cord-007726-bqlf72fe	238	1	The	the	DT
cord-007726-bqlf72fe	238	2	guidelines	guideline	NNS
cord-007726-bqlf72fe	238	3	are	be	VBP
cord-007726-bqlf72fe	238	4	most	most	RBS
cord-007726-bqlf72fe	238	5	appropriate	appropriate	JJ
cord-007726-bqlf72fe	238	6	for	for	IN
cord-007726-bqlf72fe	238	7	comparative	comparative	JJ
cord-007726-bqlf72fe	238	8	studies	study	NNS
cord-007726-bqlf72fe	238	9	involving	involve	VBG
cord-007726-bqlf72fe	238	10	two	two	CD
cord-007726-bqlf72fe	238	11	or	or	CC
cord-007726-bqlf72fe	238	12	more	more	JJR
cord-007726-bqlf72fe	238	13	groups	group	NNS
cord-007726-bqlf72fe	238	14	of	of	IN
cord-007726-bqlf72fe	238	15	experimental	experimental	JJ
cord-007726-bqlf72fe	238	16	animals	animal	NNS
cord-007726-bqlf72fe	238	17	with	with	IN
cord-007726-bqlf72fe	238	18	at	at	RB
cord-007726-bqlf72fe	238	19	least	least	RBS
cord-007726-bqlf72fe	238	20	one	one	CD
cord-007726-bqlf72fe	238	21	control	control	NN
cord-007726-bqlf72fe	238	22	group	group	NN
cord-007726-bqlf72fe	238	23	,	,	,
cord-007726-bqlf72fe	238	24	but	but	CC
cord-007726-bqlf72fe	238	25	they	-PRON-	PRP
cord-007726-bqlf72fe	238	26	also	also	RB
cord-007726-bqlf72fe	238	27	apply	apply	VBP
cord-007726-bqlf72fe	238	28	to	to	IN
cord-007726-bqlf72fe	238	29	studies	study	NNS
cord-007726-bqlf72fe	238	30	involving	involve	VBG
cord-007726-bqlf72fe	238	31	drug	drug	NN
cord-007726-bqlf72fe	238	32	dosing	dose	VBG
cord-007726-bqlf72fe	238	33	in	in	IN
cord-007726-bqlf72fe	238	34	which	which	WDT
cord-007726-bqlf72fe	238	35	a	a	DT
cord-007726-bqlf72fe	238	36	single	single	JJ
cord-007726-bqlf72fe	238	37	animal	animal	NN
cord-007726-bqlf72fe	238	38	is	be	VBZ
cord-007726-bqlf72fe	238	39	used	use	VBN
cord-007726-bqlf72fe	238	40	as	as	IN
cord-007726-bqlf72fe	238	41	its	-PRON-	PRP$
cord-007726-bqlf72fe	238	42	own	own	JJ
cord-007726-bqlf72fe	238	43	control	control	NN
cord-007726-bqlf72fe	238	44	(	(	-LRB-
cord-007726-bqlf72fe	238	45	within	within	IN
cord-007726-bqlf72fe	238	46	-	-	HYPH
cord-007726-bqlf72fe	238	47	subject	subject	NN
cord-007726-bqlf72fe	238	48	experiments	experiment	NNS
cord-007726-bqlf72fe	238	49	)	)	-RRB-
cord-007726-bqlf72fe	238	50	.	.	.
cord-007726-bqlf72fe	239	1	The	the	DT
cord-007726-bqlf72fe	239	2	guidelines	guideline	NNS
cord-007726-bqlf72fe	239	3	provide	provide	VBP
cord-007726-bqlf72fe	239	4	recommendations	recommendation	NNS
cord-007726-bqlf72fe	239	5	on	on	IN
cord-007726-bqlf72fe	239	6	what	what	WP
cord-007726-bqlf72fe	239	7	should	should	MD
cord-007726-bqlf72fe	239	8	be	be	VB
cord-007726-bqlf72fe	239	9	considered	consider	VBN
cord-007726-bqlf72fe	239	10	when	when	WRB
cord-007726-bqlf72fe	239	11	preparing	prepare	VBG
cord-007726-bqlf72fe	239	12	to	to	TO
cord-007726-bqlf72fe	239	13	report	report	VB
cord-007726-bqlf72fe	239	14	on	on	IN
cord-007726-bqlf72fe	239	15	the	the	DT
cord-007726-bqlf72fe	239	16	results	result	NNS
cord-007726-bqlf72fe	239	17	of	of	IN
cord-007726-bqlf72fe	239	18	experiments	experiment	NNS
cord-007726-bqlf72fe	239	19	involving	involve	VBG
cord-007726-bqlf72fe	239	20	live	live	JJ
cord-007726-bqlf72fe	239	21	animals	animal	NNS
cord-007726-bqlf72fe	239	22	,	,	,
cord-007726-bqlf72fe	239	23	i.e.	i.e.	FW
cord-007726-bqlf72fe	239	24	,	,	,
cord-007726-bqlf72fe	239	25	by	by	IN
cord-007726-bqlf72fe	239	26	providing	provide	VBG
cord-007726-bqlf72fe	239	27	a	a	DT
cord-007726-bqlf72fe	239	28	concise	concise	JJ
cord-007726-bqlf72fe	239	29	but	but	CC
cord-007726-bqlf72fe	239	30	thorough	thorough	JJ
cord-007726-bqlf72fe	239	31	background	background	NN
cord-007726-bqlf72fe	239	32	on	on	IN
cord-007726-bqlf72fe	239	33	the	the	DT
cord-007726-bqlf72fe	239	34	scientific	scientific	JJ
cord-007726-bqlf72fe	239	35	theory	theory	NN
cord-007726-bqlf72fe	239	36	and	and	CC
cord-007726-bqlf72fe	239	37	why	why	WRB
cord-007726-bqlf72fe	239	38	and	and	CC
cord-007726-bqlf72fe	239	39	how	how	WRB
cord-007726-bqlf72fe	239	40	animals	animal	NNS
cord-007726-bqlf72fe	239	41	were	be	VBD
cord-007726-bqlf72fe	239	42	used	use	VBN
cord-007726-bqlf72fe	239	43	to	to	TO
cord-007726-bqlf72fe	239	44	test	test	VB
cord-007726-bqlf72fe	239	45	a	a	DT
cord-007726-bqlf72fe	239	46	hypothesis	hypothesis	NN
cord-007726-bqlf72fe	239	47	,	,	,
cord-007726-bqlf72fe	239	48	a	a	DT
cord-007726-bqlf72fe	239	49	statement	statement	NN
cord-007726-bqlf72fe	239	50	on	on	IN
cord-007726-bqlf72fe	239	51	ethical	ethical	JJ
cord-007726-bqlf72fe	239	52	approvals	approval	NNS
cord-007726-bqlf72fe	239	53	and	and	CC
cord-007726-bqlf72fe	239	54	study	study	NN
cord-007726-bqlf72fe	239	55	design	design	NN
cord-007726-bqlf72fe	239	56	including	include	VBG
cord-007726-bqlf72fe	239	57	power	power	NN
cord-007726-bqlf72fe	239	58	and	and	CC
cord-007726-bqlf72fe	239	59	sample	sample	NN
cord-007726-bqlf72fe	239	60	size	size	NN
cord-007726-bqlf72fe	239	61	calculations	calculation	NNS
cord-007726-bqlf72fe	239	62	,	,	,
cord-007726-bqlf72fe	239	63	a	a	DT
cord-007726-bqlf72fe	239	64	clear	clear	JJ
cord-007726-bqlf72fe	239	65	description	description	NN
cord-007726-bqlf72fe	239	66	of	of	IN
cord-007726-bqlf72fe	239	67	the	the	DT
cord-007726-bqlf72fe	239	68	methods	method	NNS
cord-007726-bqlf72fe	239	69	used	use	VBN
cord-007726-bqlf72fe	239	70	to	to	TO
cord-007726-bqlf72fe	239	71	ensure	ensure	VB
cord-007726-bqlf72fe	239	72	repeatability	repeatability	NN
cord-007726-bqlf72fe	239	73	,	,	,
cord-007726-bqlf72fe	239	74	objective	objective	JJ
cord-007726-bqlf72fe	239	75	measurements	measurement	NNS
cord-007726-bqlf72fe	239	76	of	of	IN
cord-007726-bqlf72fe	239	77	outcomes	outcome	NNS
cord-007726-bqlf72fe	239	78	and	and	CC
cord-007726-bqlf72fe	239	79	adverse	adverse	JJ
cord-007726-bqlf72fe	239	80	effects	effect	NNS
cord-007726-bqlf72fe	239	81	,	,	,
cord-007726-bqlf72fe	239	82	and	and	CC
cord-007726-bqlf72fe	239	83	interpretation	interpretation	NN
cord-007726-bqlf72fe	239	84	of	of	IN
cord-007726-bqlf72fe	239	85	the	the	DT
cord-007726-bqlf72fe	239	86	results	result	NNS
cord-007726-bqlf72fe	239	87	in	in	IN
cord-007726-bqlf72fe	239	88	light	light	NN
cord-007726-bqlf72fe	239	89	of	of	IN
cord-007726-bqlf72fe	239	90	the	the	DT
cord-007726-bqlf72fe	239	91	available	available	JJ
cord-007726-bqlf72fe	239	92	literature	literature	NN
cord-007726-bqlf72fe	239	93	and	and	CC
cord-007726-bqlf72fe	239	94	the	the	DT
cord-007726-bqlf72fe	239	95	limitations	limitation	NNS
cord-007726-bqlf72fe	239	96	of	of	IN
cord-007726-bqlf72fe	239	97	the	the	DT
cord-007726-bqlf72fe	239	98	study	study	NN
cord-007726-bqlf72fe	239	99	.	.	.
cord-007726-bqlf72fe	240	1	In	in	IN
cord-007726-bqlf72fe	240	2	addition	addition	NN
cord-007726-bqlf72fe	240	3	to	to	IN
cord-007726-bqlf72fe	240	4	the	the	DT
cord-007726-bqlf72fe	240	5	positive	positive	JJ
cord-007726-bqlf72fe	240	6	impact	impact	NN
cord-007726-bqlf72fe	240	7	of	of	IN
cord-007726-bqlf72fe	240	8	the	the	DT
cord-007726-bqlf72fe	240	9	ARRIVE	ARRIVE	NNP
cord-007726-bqlf72fe	240	10	guidelines	guideline	NNS
cord-007726-bqlf72fe	240	11	on	on	IN
cord-007726-bqlf72fe	240	12	reducing	reduce	VBG
cord-007726-bqlf72fe	240	13	the	the	DT
cord-007726-bqlf72fe	240	14	number	number	NN
cord-007726-bqlf72fe	240	15	of	of	IN
cord-007726-bqlf72fe	240	16	animals	animal	NNS
cord-007726-bqlf72fe	240	17	used	use	VBN
cord-007726-bqlf72fe	240	18	in	in	IN
cord-007726-bqlf72fe	240	19	experiments	experiment	NNS
cord-007726-bqlf72fe	240	20	,	,	,
cord-007726-bqlf72fe	240	21	this	this	DT
cord-007726-bqlf72fe	240	22	checklist	checklist	NN
cord-007726-bqlf72fe	240	23	provides	provide	VBZ
cord-007726-bqlf72fe	240	24	an	an	DT
cord-007726-bqlf72fe	240	25	easy	easy	JJ
cord-007726-bqlf72fe	240	26	-	-	HYPH
cord-007726-bqlf72fe	240	27	tofollow	tofollow	NN
cord-007726-bqlf72fe	240	28	roadmap	roadmap	NN
cord-007726-bqlf72fe	240	29	on	on	IN
cord-007726-bqlf72fe	240	30	what	what	WP
cord-007726-bqlf72fe	240	31	is	be	VBZ
cord-007726-bqlf72fe	240	32	required	require	VBN
cord-007726-bqlf72fe	240	33	for	for	IN
cord-007726-bqlf72fe	240	34	good	good	JJ
cord-007726-bqlf72fe	240	35	quality	quality	NN
cord-007726-bqlf72fe	240	36	reporting	reporting	NN
cord-007726-bqlf72fe	240	37	of	of	IN
cord-007726-bqlf72fe	240	38	experimental	experimental	JJ
cord-007726-bqlf72fe	240	39	results	result	NNS
cord-007726-bqlf72fe	240	40	.	.	.
cord-007726-bqlf72fe	241	1	In	in	IN
cord-007726-bqlf72fe	241	2	conclusion	conclusion	NN
cord-007726-bqlf72fe	241	3	,	,	,
cord-007726-bqlf72fe	241	4	the	the	DT
cord-007726-bqlf72fe	241	5	use	use	NN
cord-007726-bqlf72fe	241	6	of	of	IN
cord-007726-bqlf72fe	241	7	animals	animal	NNS
cord-007726-bqlf72fe	241	8	in	in	IN
cord-007726-bqlf72fe	241	9	research	research	NN
cord-007726-bqlf72fe	241	10	will	will	MD
cord-007726-bqlf72fe	241	11	continue	continue	VB
cord-007726-bqlf72fe	241	12	to	to	TO
cord-007726-bqlf72fe	241	13	be	be	VB
cord-007726-bqlf72fe	241	14	an	an	DT
cord-007726-bqlf72fe	241	15	important	important	JJ
cord-007726-bqlf72fe	241	16	aspect	aspect	NN
cord-007726-bqlf72fe	241	17	of	of	IN
cord-007726-bqlf72fe	241	18	medical	medical	JJ
cord-007726-bqlf72fe	241	19	research	research	NN
cord-007726-bqlf72fe	241	20	,	,	,
cord-007726-bqlf72fe	241	21	and	and	CC
cord-007726-bqlf72fe	241	22	these	these	DT
cord-007726-bqlf72fe	241	23	procedures	procedure	NNS
cord-007726-bqlf72fe	241	24	can	can	MD
cord-007726-bqlf72fe	241	25	be	be	VB
cord-007726-bqlf72fe	241	26	ethically	ethically	RB
cord-007726-bqlf72fe	241	27	justified	justify	VBN
cord-007726-bqlf72fe	241	28	provided	provide	VBN
cord-007726-bqlf72fe	241	29	the	the	DT
cord-007726-bqlf72fe	241	30	proper	proper	JJ
cord-007726-bqlf72fe	241	31	controls	control	NNS
cord-007726-bqlf72fe	241	32	are	be	VBP
cord-007726-bqlf72fe	241	33	in	in	IN
cord-007726-bqlf72fe	241	34	place	place	NN
cord-007726-bqlf72fe	241	35	.	.	.
cord-007726-bqlf72fe	242	1	The	the	DT
cord-007726-bqlf72fe	242	2	benefits	benefit	NNS
cord-007726-bqlf72fe	242	3	of	of	IN
cord-007726-bqlf72fe	242	4	animal	animal	NN
cord-007726-bqlf72fe	242	5	research	research	NN
cord-007726-bqlf72fe	242	6	have	have	VBP
cord-007726-bqlf72fe	242	7	been	be	VBN
cord-007726-bqlf72fe	242	8	vital	vital	JJ
cord-007726-bqlf72fe	242	9	to	to	IN
cord-007726-bqlf72fe	242	10	the	the	DT
cord-007726-bqlf72fe	242	11	progress	progress	NN
cord-007726-bqlf72fe	242	12	of	of	IN
cord-007726-bqlf72fe	242	13	medical	medical	JJ
cord-007726-bqlf72fe	242	14	science	science	NN
cord-007726-bqlf72fe	242	15	;	;	:
cord-007726-bqlf72fe	242	16	abandoning	abandon	VBG
cord-007726-bqlf72fe	242	17	these	these	DT
cord-007726-bqlf72fe	242	18	studies	study	NNS
cord-007726-bqlf72fe	242	19	would	would	MD
cord-007726-bqlf72fe	242	20	have	have	VB
cord-007726-bqlf72fe	242	21	severe	severe	JJ
cord-007726-bqlf72fe	242	22	negative	negative	JJ
cord-007726-bqlf72fe	242	23	consequences	consequence	NNS
cord-007726-bqlf72fe	242	24	on	on	IN
cord-007726-bqlf72fe	242	25	human	human	JJ
cord-007726-bqlf72fe	242	26	health	health	NN
cord-007726-bqlf72fe	242	27	.	.	.
cord-007726-bqlf72fe	243	1	By	by	IN
cord-007726-bqlf72fe	243	2	considering	consider	VBG
cord-007726-bqlf72fe	243	3	aspects	aspect	NNS
cord-007726-bqlf72fe	243	4	such	such	JJ
cord-007726-bqlf72fe	243	5	as	as	IN
cord-007726-bqlf72fe	243	6	the	the	DT
cord-007726-bqlf72fe	243	7	3Rs	3rs	NN
cord-007726-bqlf72fe	243	8	and	and	CC
cord-007726-bqlf72fe	243	9	the	the	DT
cord-007726-bqlf72fe	243	10	ARRIVE	ARRIVE	NNP
cord-007726-bqlf72fe	243	11	guidelines	guideline	NNS
cord-007726-bqlf72fe	243	12	in	in	IN
cord-007726-bqlf72fe	243	13	planning	plan	VBG
cord-007726-bqlf72fe	243	14	experiments	experiment	NNS
cord-007726-bqlf72fe	243	15	involving	involve	VBG
cord-007726-bqlf72fe	243	16	live	live	JJ
cord-007726-bqlf72fe	243	17	animals	animal	NNS
cord-007726-bqlf72fe	243	18	,	,	,
cord-007726-bqlf72fe	243	19	the	the	DT
cord-007726-bqlf72fe	243	20	number	number	NN
cord-007726-bqlf72fe	243	21	of	of	IN
cord-007726-bqlf72fe	243	22	animals	animal	NNS
cord-007726-bqlf72fe	243	23	used	use	VBN
cord-007726-bqlf72fe	243	24	and	and	CC
cord-007726-bqlf72fe	243	25	suffering	suffering	NN
cord-007726-bqlf72fe	243	26	of	of	IN
cord-007726-bqlf72fe	243	27	these	these	DT
cord-007726-bqlf72fe	243	28	animals	animal	NNS
cord-007726-bqlf72fe	243	29	for	for	IN
cord-007726-bqlf72fe	243	30	the	the	DT
cord-007726-bqlf72fe	243	31	benefit	benefit	NN
cord-007726-bqlf72fe	243	32	of	of	IN
cord-007726-bqlf72fe	243	33	human	human	JJ
cord-007726-bqlf72fe	243	34	health	health	NN
cord-007726-bqlf72fe	243	35	can	can	MD
cord-007726-bqlf72fe	243	36	be	be	VB
cord-007726-bqlf72fe	243	37	minimized	minimize	VBN
cord-007726-bqlf72fe	243	38	.	.	.
cord-007726-bqlf72fe	244	1	This	this	DT
cord-007726-bqlf72fe	244	2	requires	require	VBZ
cord-007726-bqlf72fe	244	3	a	a	DT
cord-007726-bqlf72fe	244	4	strong	strong	JJ
cord-007726-bqlf72fe	244	5	regulatory	regulatory	JJ
cord-007726-bqlf72fe	244	6	framework	framework	NN
cord-007726-bqlf72fe	244	7	such	such	JJ
cord-007726-bqlf72fe	244	8	as	as	IN
cord-007726-bqlf72fe	244	9	that	that	DT
cord-007726-bqlf72fe	244	10	found	find	VBN
cord-007726-bqlf72fe	244	11	in	in	IN
cord-007726-bqlf72fe	244	12	the	the	DT
cord-007726-bqlf72fe	244	13	UK	UK	NNP
cord-007726-bqlf72fe	244	14	and	and	CC
cord-007726-bqlf72fe	244	15	many	many	JJ
cord-007726-bqlf72fe	244	16	other	other	JJ
cord-007726-bqlf72fe	244	17	countries	country	NNS
cord-007726-bqlf72fe	244	18	,	,	,
cord-007726-bqlf72fe	244	19	as	as	RB
cord-007726-bqlf72fe	244	20	well	well	RB
cord-007726-bqlf72fe	244	21	an	an	DT
cord-007726-bqlf72fe	244	22	ongoing	ongoing	JJ
cord-007726-bqlf72fe	244	23	public	public	JJ
cord-007726-bqlf72fe	244	24	debate	debate	NN
cord-007726-bqlf72fe	244	25	on	on	IN
cord-007726-bqlf72fe	244	26	the	the	DT
cord-007726-bqlf72fe	244	27	advantages	advantage	NNS
cord-007726-bqlf72fe	244	28	and	and	CC
cord-007726-bqlf72fe	244	29	limitations	limitation	NNS
cord-007726-bqlf72fe	244	30	of	of	IN
cord-007726-bqlf72fe	244	31	animal	animal	NN
cord-007726-bqlf72fe	244	32	experimentation	experimentation	NN
cord-007726-bqlf72fe	244	33	.	.	.
cord-007726-bqlf72fe	245	1	Use	Use	NNP
cord-007726-bqlf72fe	245	2	of	of	IN
cord-007726-bqlf72fe	245	3	house	house	NN
cord-007726-bqlf72fe	245	4	mice	mouse	NNS
cord-007726-bqlf72fe	245	5	in	in	IN
cord-007726-bqlf72fe	245	6	biomedical	biomedical	JJ
cord-007726-bqlf72fe	245	7	research	research	NN
cord-007726-bqlf72fe	246	1	The	the	DT
cord-007726-bqlf72fe	246	2	laboratory	laboratory	NN
cord-007726-bqlf72fe	246	3	mouse	mouse	NN
cord-007726-bqlf72fe	246	4	A	a	DT
cord-007726-bqlf72fe	246	5	comparative	comparative	JJ
cord-007726-bqlf72fe	246	6	encyclopedia	encyclopedia	NN
cord-007726-bqlf72fe	246	7	of	of	IN
cord-007726-bqlf72fe	246	8	DNA	dna	NN
cord-007726-bqlf72fe	246	9	elements	element	NNS
cord-007726-bqlf72fe	246	10	in	in	IN
cord-007726-bqlf72fe	246	11	the	the	DT
cord-007726-bqlf72fe	246	12	mouse	mouse	NN
cord-007726-bqlf72fe	246	13	genome	genome	NN
cord-007726-bqlf72fe	246	14	Principles	principle	NNS
cord-007726-bqlf72fe	246	15	of	of	IN
cord-007726-bqlf72fe	246	16	regulatory	regulatory	JJ
cord-007726-bqlf72fe	246	17	information	information	NN
cord-007726-bqlf72fe	246	18	conservation	conservation	NN
cord-007726-bqlf72fe	246	19	between	between	IN
cord-007726-bqlf72fe	246	20	mouse	mouse	NN
cord-007726-bqlf72fe	246	21	and	and	CC
cord-007726-bqlf72fe	246	22	human	human	NN
cord-007726-bqlf72fe	246	23	Of	of	IN
cord-007726-bqlf72fe	246	24	mice	mouse	NNS
cord-007726-bqlf72fe	246	25	and	and	CC
cord-007726-bqlf72fe	246	26	men	man	NNS
cord-007726-bqlf72fe	246	27	:	:	:
cord-007726-bqlf72fe	246	28	aligning	align	VBG
cord-007726-bqlf72fe	246	29	mouse	mouse	NN
cord-007726-bqlf72fe	246	30	and	and	CC
cord-007726-bqlf72fe	246	31	human	human	JJ
cord-007726-bqlf72fe	246	32	anatomies	anatomy	NNS
cord-007726-bqlf72fe	246	33	Mouse	Mouse	NNP
cord-007726-bqlf72fe	246	34	models	model	NNS
cord-007726-bqlf72fe	246	35	of	of	IN
cord-007726-bqlf72fe	246	36	human	human	JJ
cord-007726-bqlf72fe	246	37	disease	disease	NN
cord-007726-bqlf72fe	246	38	:	:	:
cord-007726-bqlf72fe	246	39	an	an	DT
cord-007726-bqlf72fe	246	40	evolutionary	evolutionary	JJ
cord-007726-bqlf72fe	246	41	perspective	perspective	NN
cord-007726-bqlf72fe	246	42	Structure	structure	NN
cord-007726-bqlf72fe	246	43	and	and	CC
cord-007726-bqlf72fe	246	44	composition	composition	NN
cord-007726-bqlf72fe	246	45	of	of	IN
cord-007726-bqlf72fe	246	46	pulmonary	pulmonary	JJ
cord-007726-bqlf72fe	246	47	arteries	artery	NNS
cord-007726-bqlf72fe	246	48	,	,	,
cord-007726-bqlf72fe	246	49	capillaries	capillary	NNS
cord-007726-bqlf72fe	246	50	,	,	,
cord-007726-bqlf72fe	246	51	and	and	CC
cord-007726-bqlf72fe	246	52	veins	vein	VBZ
cord-007726-bqlf72fe	246	53	Angiogenesis	Angiogenesis	NNP
cord-007726-bqlf72fe	246	54	in	in	IN
cord-007726-bqlf72fe	246	55	the	the	DT
cord-007726-bqlf72fe	246	56	mouse	mouse	NN
cord-007726-bqlf72fe	246	57	lung	lung	NN
cord-007726-bqlf72fe	246	58	Lung	Lung	NNP
cord-007726-bqlf72fe	246	59	cancer	cancer	NN
cord-007726-bqlf72fe	246	60	perfusion	perfusion	NN
cord-007726-bqlf72fe	246	61	:	:	:
cord-007726-bqlf72fe	246	62	can	can	MD
cord-007726-bqlf72fe	246	63	we	-PRON-	PRP
cord-007726-bqlf72fe	246	64	measure	measure	VB
cord-007726-bqlf72fe	246	65	pulmonary	pulmonary	JJ
cord-007726-bqlf72fe	246	66	and	and	CC
cord-007726-bqlf72fe	246	67	bronchial	bronchial	JJ
cord-007726-bqlf72fe	246	68	circulation	circulation	NN
cord-007726-bqlf72fe	246	69	simultaneously	simultaneously	RB
cord-007726-bqlf72fe	246	70	?	?	.
cord-007726-bqlf72fe	247	1	Origin	origin	NN
cord-007726-bqlf72fe	247	2	and	and	CC
cord-007726-bqlf72fe	247	3	evolution	evolution	NN
cord-007726-bqlf72fe	247	4	of	of	IN
cord-007726-bqlf72fe	247	5	the	the	DT
cord-007726-bqlf72fe	247	6	adaptive	adaptive	JJ
cord-007726-bqlf72fe	247	7	immune	immune	JJ
cord-007726-bqlf72fe	247	8	system	system	NN
cord-007726-bqlf72fe	247	9	:	:	:
cord-007726-bqlf72fe	247	10	genetic	genetic	JJ
cord-007726-bqlf72fe	247	11	events	event	NNS
cord-007726-bqlf72fe	247	12	and	and	CC
cord-007726-bqlf72fe	247	13	selective	selective	JJ
cord-007726-bqlf72fe	247	14	pressures	pressure	NNS
cord-007726-bqlf72fe	248	1	The	the	DT
cord-007726-bqlf72fe	248	2	evolutionary	evolutionary	JJ
cord-007726-bqlf72fe	248	3	basis	basis	NN
cord-007726-bqlf72fe	248	4	for	for	IN
cord-007726-bqlf72fe	248	5	differences	difference	NNS
cord-007726-bqlf72fe	248	6	between	between	IN
cord-007726-bqlf72fe	248	7	the	the	DT
cord-007726-bqlf72fe	248	8	immune	immune	JJ
cord-007726-bqlf72fe	248	9	systems	system	NNS
cord-007726-bqlf72fe	248	10	of	of	IN
cord-007726-bqlf72fe	248	11	man	man	NN
cord-007726-bqlf72fe	248	12	,	,	,
cord-007726-bqlf72fe	248	13	mouse	mouse	NN
cord-007726-bqlf72fe	248	14	,	,	,
cord-007726-bqlf72fe	248	15	pig	pig	NN
cord-007726-bqlf72fe	248	16	and	and	CC
cord-007726-bqlf72fe	248	17	ruminants	ruminant	NNS
cord-007726-bqlf72fe	248	18	Of	of	IN
cord-007726-bqlf72fe	248	19	mice	mouse	NNS
cord-007726-bqlf72fe	248	20	and	and	CC
cord-007726-bqlf72fe	248	21	not	not	RB
cord-007726-bqlf72fe	248	22	men	man	NNS
cord-007726-bqlf72fe	248	23	:	:	:
cord-007726-bqlf72fe	248	24	differences	difference	NNS
cord-007726-bqlf72fe	248	25	between	between	IN
cord-007726-bqlf72fe	248	26	mouse	mouse	NN
cord-007726-bqlf72fe	248	27	and	and	CC
cord-007726-bqlf72fe	248	28	human	human	JJ
cord-007726-bqlf72fe	248	29	immunology	immunology	NN
cord-007726-bqlf72fe	248	30	Gender	gender	NN
cord-007726-bqlf72fe	248	31	dimorphism	dimorphism	NN
cord-007726-bqlf72fe	248	32	in	in	IN
cord-007726-bqlf72fe	248	33	differential	differential	JJ
cord-007726-bqlf72fe	248	34	peripheral	peripheral	JJ
cord-007726-bqlf72fe	248	35	blood	blood	NN
cord-007726-bqlf72fe	248	36	leukocyte	leukocyte	NN
cord-007726-bqlf72fe	248	37	counts	count	VBZ
cord-007726-bqlf72fe	248	38	in	in	IN
cord-007726-bqlf72fe	248	39	mice	mouse	NNS
cord-007726-bqlf72fe	248	40	using	use	VBG
cord-007726-bqlf72fe	248	41	cardiac	cardiac	NN
cord-007726-bqlf72fe	248	42	,	,	,
cord-007726-bqlf72fe	248	43	tail	tail	NN
cord-007726-bqlf72fe	248	44	,	,	,
cord-007726-bqlf72fe	248	45	foot	foot	NN
cord-007726-bqlf72fe	248	46	,	,	,
cord-007726-bqlf72fe	248	47	and	and	CC
cord-007726-bqlf72fe	248	48	saphenous	saphenous	JJ
cord-007726-bqlf72fe	248	49	vein	vein	NN
cord-007726-bqlf72fe	248	50	puncture	puncture	NN
cord-007726-bqlf72fe	248	51	methods	method	NNS
cord-007726-bqlf72fe	248	52	Species	species	VBP
cord-007726-bqlf72fe	248	53	differences	difference	NNS
cord-007726-bqlf72fe	248	54	in	in	IN
cord-007726-bqlf72fe	248	55	the	the	DT
cord-007726-bqlf72fe	248	56	expression	expression	NN
cord-007726-bqlf72fe	248	57	of	of	IN
cord-007726-bqlf72fe	248	58	major	major	JJ
cord-007726-bqlf72fe	248	59	histocompatibility	histocompatibility	NN
cord-007726-bqlf72fe	248	60	complex	complex	JJ
cord-007726-bqlf72fe	248	61	class	class	NN
cord-007726-bqlf72fe	248	62	II	ii	CD
cord-007726-bqlf72fe	248	63	antigens	antigen	NNS
cord-007726-bqlf72fe	248	64	on	on	IN
cord-007726-bqlf72fe	248	65	coronary	coronary	JJ
cord-007726-bqlf72fe	248	66	artery	artery	NN
cord-007726-bqlf72fe	248	67	endothelium	endothelium	NN
cord-007726-bqlf72fe	248	68	:	:	:
cord-007726-bqlf72fe	248	69	implications	implication	NNS
cord-007726-bqlf72fe	248	70	for	for	IN
cord-007726-bqlf72fe	248	71	cellmediated	cellmediate	VBN
cord-007726-bqlf72fe	248	72	xenoreactivity	xenoreactivity	NNP
cord-007726-bqlf72fe	248	73	ICOS	ICOS	NNP
cord-007726-bqlf72fe	248	74	is	be	VBZ
cord-007726-bqlf72fe	248	75	critical	critical	JJ
cord-007726-bqlf72fe	248	76	for	for	IN
cord-007726-bqlf72fe	248	77	CD40-mediated	cd40-mediated	JJ
cord-007726-bqlf72fe	248	78	antibody	antibody	NN
cord-007726-bqlf72fe	248	79	class	class	NN
cord-007726-bqlf72fe	248	80	switching	switch	VBG
cord-007726-bqlf72fe	248	81	Homozygous	Homozygous	NNP
cord-007726-bqlf72fe	248	82	loss	loss	NN
cord-007726-bqlf72fe	248	83	of	of	IN
cord-007726-bqlf72fe	248	84	ICOS	ICOS	NNP
cord-007726-bqlf72fe	248	85	is	be	VBZ
cord-007726-bqlf72fe	248	86	associated	associate	VBN
cord-007726-bqlf72fe	248	87	with	with	IN
cord-007726-bqlf72fe	248	88	adultonset	adultonset	NNP
cord-007726-bqlf72fe	248	89	common	common	JJ
cord-007726-bqlf72fe	248	90	variable	variable	JJ
cord-007726-bqlf72fe	248	91	immunodeficiency	immunodeficiency	NN
cord-007726-bqlf72fe	249	1	B7-H3	B7-H3	NNP
cord-007726-bqlf72fe	249	2	:	:	:
cord-007726-bqlf72fe	249	3	a	a	DT
cord-007726-bqlf72fe	249	4	costimulatory	costimulatory	NN
cord-007726-bqlf72fe	249	5	molecule	molecule	NN
cord-007726-bqlf72fe	249	6	for	for	IN
cord-007726-bqlf72fe	249	7	T	T	NNP
cord-007726-bqlf72fe	249	8	cell	cell	NN
cord-007726-bqlf72fe	249	9	activation	activation	NN
cord-007726-bqlf72fe	249	10	and	and	CC
cord-007726-bqlf72fe	249	11	IFN	IFN	NNP
cord-007726-bqlf72fe	249	12	-	-	HYPH
cord-007726-bqlf72fe	249	13	gamma	gamma	NNP
cord-007726-bqlf72fe	249	14	production	production	NN
cord-007726-bqlf72fe	249	15	Global	global	JJ
cord-007726-bqlf72fe	249	16	gene	gene	NN
cord-007726-bqlf72fe	249	17	regulation	regulation	NN
cord-007726-bqlf72fe	249	18	during	during	IN
cord-007726-bqlf72fe	249	19	activation	activation	NN
cord-007726-bqlf72fe	249	20	of	of	IN
cord-007726-bqlf72fe	249	21	immunoglobulin	immunoglobulin	NN
cord-007726-bqlf72fe	249	22	class	class	NN
cord-007726-bqlf72fe	249	23	switching	switch	VBG
cord-007726-bqlf72fe	249	24	in	in	IN
cord-007726-bqlf72fe	249	25	human	human	JJ
cord-007726-bqlf72fe	249	26	B	b	NN
cord-007726-bqlf72fe	249	27	cells	cell	NNS
cord-007726-bqlf72fe	249	28	Selective	selective	JJ
cord-007726-bqlf72fe	249	29	loss	loss	NN
cord-007726-bqlf72fe	249	30	of	of	IN
cord-007726-bqlf72fe	249	31	type	type	NN
cord-007726-bqlf72fe	250	1	I	-PRON-	PRP
cord-007726-bqlf72fe	250	2	interferon	interferon	NN
cord-007726-bqlf72fe	250	3	-	-	HYPH
cord-007726-bqlf72fe	250	4	induced	induce	VBN
cord-007726-bqlf72fe	250	5	STAT4	STAT4	NNP
cord-007726-bqlf72fe	250	6	activation	activation	NN
cord-007726-bqlf72fe	250	7	caused	cause	VBN
cord-007726-bqlf72fe	250	8	by	by	IN
cord-007726-bqlf72fe	250	9	a	a	DT
cord-007726-bqlf72fe	250	10	minisatellite	minisatellite	JJ
cord-007726-bqlf72fe	250	11	insertion	insertion	NN
cord-007726-bqlf72fe	250	12	in	in	IN
cord-007726-bqlf72fe	250	13	mouse	mouse	NN
cord-007726-bqlf72fe	250	14	Stat2	Stat2	NNP
cord-007726-bqlf72fe	250	15	Regulation	Regulation	NNP
cord-007726-bqlf72fe	250	16	of	of	IN
cord-007726-bqlf72fe	250	17	human	human	JJ
cord-007726-bqlf72fe	250	18	helper	helper	NN
cord-007726-bqlf72fe	250	19	T	T	NNP
cord-007726-bqlf72fe	250	20	cell	cell	NN
cord-007726-bqlf72fe	250	21	subset	subset	VBN
cord-007726-bqlf72fe	250	22	differentiation	differentiation	NN
cord-007726-bqlf72fe	250	23	by	by	IN
cord-007726-bqlf72fe	250	24	cytokines	cytokine	NNS
cord-007726-bqlf72fe	250	25	Functional	functional	JJ
cord-007726-bqlf72fe	250	26	dichotomy	dichotomy	NN
cord-007726-bqlf72fe	250	27	in	in	IN
cord-007726-bqlf72fe	250	28	the	the	DT
cord-007726-bqlf72fe	250	29	CD4	CD4	NNP
cord-007726-bqlf72fe	250	30	+	+	CC
cord-007726-bqlf72fe	250	31	T	T	NNP
cord-007726-bqlf72fe	250	32	cell	cell	NN
cord-007726-bqlf72fe	250	33	response	response	NN
cord-007726-bqlf72fe	250	34	to	to	IN
cord-007726-bqlf72fe	250	35	Schistosoma	Schistosoma	NNP
cord-007726-bqlf72fe	250	36	mansoni	mansoni	NNP
cord-007726-bqlf72fe	250	37	What	what	WDT
cord-007726-bqlf72fe	250	38	animal	animal	NN
cord-007726-bqlf72fe	250	39	models	model	NNS
cord-007726-bqlf72fe	250	40	teach	teach	VBP
cord-007726-bqlf72fe	250	41	humans	human	NNS
cord-007726-bqlf72fe	250	42	about	about	IN
cord-007726-bqlf72fe	250	43	tuberculosis	tuberculosis	NN
cord-007726-bqlf72fe	250	44	Cutting	cutting	NN
cord-007726-bqlf72fe	250	45	edge	edge	NN
cord-007726-bqlf72fe	250	46	:	:	:
cord-007726-bqlf72fe	250	47	check	check	VB
cord-007726-bqlf72fe	250	48	your	-PRON-	PRP$
cord-007726-bqlf72fe	250	49	mice	mice	NN
cord-007726-bqlf72fe	250	50	-	-	HYPH
cord-007726-bqlf72fe	250	51	a	a	DT
cord-007726-bqlf72fe	250	52	point	point	NN
cord-007726-bqlf72fe	250	53	mutation	mutation	NN
cord-007726-bqlf72fe	250	54	in	in	IN
cord-007726-bqlf72fe	250	55	the	the	DT
cord-007726-bqlf72fe	250	56	Ncr1	Ncr1	NNP
cord-007726-bqlf72fe	250	57	locus	locus	NN
cord-007726-bqlf72fe	250	58	identified	identify	VBN
cord-007726-bqlf72fe	250	59	in	in	IN
cord-007726-bqlf72fe	250	60	CD45.1	cd45.1	NN
cord-007726-bqlf72fe	250	61	congenic	congenic	NNP
cord-007726-bqlf72fe	250	62	mice	mouse	NNS
cord-007726-bqlf72fe	250	63	with	with	IN
cord-007726-bqlf72fe	250	64	consequences	consequence	NNS
cord-007726-bqlf72fe	250	65	in	in	IN
cord-007726-bqlf72fe	250	66	mouse	mouse	NN
cord-007726-bqlf72fe	250	67	susceptibility	susceptibility	NN
cord-007726-bqlf72fe	250	68	to	to	IN
cord-007726-bqlf72fe	250	69	infection	infection	NN
cord-007726-bqlf72fe	250	70	Comparative	comparative	JJ
cord-007726-bqlf72fe	250	71	computational	computational	JJ
cord-007726-bqlf72fe	250	72	analysis	analysis	NN
cord-007726-bqlf72fe	250	73	of	of	IN
cord-007726-bqlf72fe	250	74	pluripotency	pluripotency	NN
cord-007726-bqlf72fe	250	75	in	in	IN
cord-007726-bqlf72fe	250	76	human	human	NN
cord-007726-bqlf72fe	250	77	and	and	CC
cord-007726-bqlf72fe	250	78	mouse	mouse	NN
cord-007726-bqlf72fe	250	79	stem	stem	NN
cord-007726-bqlf72fe	250	80	cells	cell	NNS
cord-007726-bqlf72fe	251	1	The	the	DT
cord-007726-bqlf72fe	251	2	transition	transition	NN
cord-007726-bqlf72fe	251	3	from	from	IN
cord-007726-bqlf72fe	251	4	primary	primary	JJ
cord-007726-bqlf72fe	251	5	culture	culture	NN
cord-007726-bqlf72fe	251	6	to	to	IN
cord-007726-bqlf72fe	251	7	spontaneous	spontaneous	JJ
cord-007726-bqlf72fe	251	8	immortalization	immortalization	NN
cord-007726-bqlf72fe	251	9	in	in	IN
cord-007726-bqlf72fe	251	10	mouse	mouse	NN
cord-007726-bqlf72fe	251	11	fibroblast	fibroblast	NN
cord-007726-bqlf72fe	251	12	populations	population	NNS
cord-007726-bqlf72fe	251	13	Studying	study	VBG
cord-007726-bqlf72fe	251	14	human	human	JJ
cord-007726-bqlf72fe	251	15	respiratory	respiratory	JJ
cord-007726-bqlf72fe	251	16	disease	disease	NN
cord-007726-bqlf72fe	251	17	in	in	IN
cord-007726-bqlf72fe	251	18	animals	animal	NNS
cord-007726-bqlf72fe	251	19	-role	-role	:
cord-007726-bqlf72fe	251	20	of	of	IN
cord-007726-bqlf72fe	251	21	induced	induce	VBN
cord-007726-bqlf72fe	251	22	and	and	CC
cord-007726-bqlf72fe	251	23	naturally	naturally	RB
cord-007726-bqlf72fe	251	24	occurring	occur	VBG
cord-007726-bqlf72fe	251	25	models	model	NNS
cord-007726-bqlf72fe	251	26	Role	role	NN
cord-007726-bqlf72fe	251	27	of	of	IN
cord-007726-bqlf72fe	251	28	mast	mast	NN
cord-007726-bqlf72fe	251	29	cells	cell	NNS
cord-007726-bqlf72fe	251	30	in	in	IN
cord-007726-bqlf72fe	251	31	allergic	allergic	JJ
cord-007726-bqlf72fe	251	32	and	and	CC
cord-007726-bqlf72fe	251	33	non	non	JJ
cord-007726-bqlf72fe	251	34	-	-	JJ
cord-007726-bqlf72fe	251	35	allergic	allergic	JJ
cord-007726-bqlf72fe	251	36	immune	immune	JJ
cord-007726-bqlf72fe	251	37	responses	response	NNS
cord-007726-bqlf72fe	251	38	:	:	:
cord-007726-bqlf72fe	251	39	comparison	comparison	NN
cord-007726-bqlf72fe	251	40	of	of	IN
cord-007726-bqlf72fe	251	41	human	human	JJ
cord-007726-bqlf72fe	251	42	and	and	CC
cord-007726-bqlf72fe	251	43	murine	murine	JJ
cord-007726-bqlf72fe	251	44	data	datum	NNS
cord-007726-bqlf72fe	251	45	Allergic	allergic	JJ
cord-007726-bqlf72fe	251	46	airway	airway	NN
cord-007726-bqlf72fe	251	47	inflammation	inflammation	NN
cord-007726-bqlf72fe	251	48	induces	induce	VBZ
cord-007726-bqlf72fe	251	49	migration	migration	NN
cord-007726-bqlf72fe	251	50	of	of	IN
cord-007726-bqlf72fe	251	51	mast	mast	JJ
cord-007726-bqlf72fe	251	52	cell	cell	NN
cord-007726-bqlf72fe	251	53	populations	population	NNS
cord-007726-bqlf72fe	251	54	into	into	IN
cord-007726-bqlf72fe	251	55	the	the	DT
cord-007726-bqlf72fe	251	56	mouse	mouse	NN
cord-007726-bqlf72fe	251	57	airway	airway	NN
cord-007726-bqlf72fe	251	58	Novel	Novel	NNP
cord-007726-bqlf72fe	251	59	site	site	NN
cord-007726-bqlf72fe	251	60	-	-	HYPH
cord-007726-bqlf72fe	251	61	specific	specific	JJ
cord-007726-bqlf72fe	251	62	mast	mast	JJ
cord-007726-bqlf72fe	251	63	cell	cell	NN
cord-007726-bqlf72fe	251	64	subpopulations	subpopulation	NNS
cord-007726-bqlf72fe	251	65	in	in	IN
cord-007726-bqlf72fe	251	66	the	the	DT
cord-007726-bqlf72fe	251	67	human	human	JJ
cord-007726-bqlf72fe	251	68	lung	lung	NN
cord-007726-bqlf72fe	251	69	Animal	Animal	NNP
cord-007726-bqlf72fe	251	70	models	model	NNS
cord-007726-bqlf72fe	251	71	of	of	IN
cord-007726-bqlf72fe	251	72	asthma	asthma	NN
cord-007726-bqlf72fe	251	73	:	:	:
cord-007726-bqlf72fe	251	74	reprise	reprise	VB
cord-007726-bqlf72fe	251	75	or	or	CC
cord-007726-bqlf72fe	251	76	reboot	reboot	VB
cord-007726-bqlf72fe	251	77	?	?	.
cord-007726-bqlf72fe	252	1	Emerging	emerge	VBG
cord-007726-bqlf72fe	252	2	molecular	molecular	JJ
cord-007726-bqlf72fe	252	3	phenotypes	phenotype	NNS
cord-007726-bqlf72fe	252	4	of	of	IN
cord-007726-bqlf72fe	252	5	asthma	asthma	NN
cord-007726-bqlf72fe	252	6	Allergens	allergen	NNS
cord-007726-bqlf72fe	252	7	in	in	IN
cord-007726-bqlf72fe	252	8	veterinary	veterinary	JJ
cord-007726-bqlf72fe	252	9	medicine	medicine	NN
cord-007726-bqlf72fe	252	10	Immunologic	immunologic	JJ
cord-007726-bqlf72fe	252	11	responses	response	NNS
cord-007726-bqlf72fe	252	12	following	follow	VBG
cord-007726-bqlf72fe	252	13	respiratory	respiratory	JJ
cord-007726-bqlf72fe	252	14	sensitization	sensitization	NN
cord-007726-bqlf72fe	252	15	to	to	IN
cord-007726-bqlf72fe	252	16	house	house	NN
cord-007726-bqlf72fe	252	17	dust	dust	NN
cord-007726-bqlf72fe	252	18	mite	mite	NN
cord-007726-bqlf72fe	252	19	allergens	allergen	NNS
cord-007726-bqlf72fe	252	20	in	in	IN
cord-007726-bqlf72fe	252	21	mice	mouse	NNS
cord-007726-bqlf72fe	252	22	Understanding	understand	VBG
cord-007726-bqlf72fe	252	23	asthma	asthma	NN
cord-007726-bqlf72fe	252	24	using	use	VBG
cord-007726-bqlf72fe	252	25	animal	animal	NN
cord-007726-bqlf72fe	252	26	models	model	NNS
cord-007726-bqlf72fe	252	27	Use	Use	NNP
cord-007726-bqlf72fe	252	28	of	of	IN
cord-007726-bqlf72fe	252	29	the	the	DT
cord-007726-bqlf72fe	252	30	cockroach	cockroach	NN
cord-007726-bqlf72fe	252	31	antigen	antigen	NN
cord-007726-bqlf72fe	252	32	model	model	NN
cord-007726-bqlf72fe	252	33	of	of	IN
cord-007726-bqlf72fe	252	34	acute	acute	JJ
cord-007726-bqlf72fe	252	35	asthma	asthma	NN
cord-007726-bqlf72fe	252	36	to	to	TO
cord-007726-bqlf72fe	252	37	determine	determine	VB
cord-007726-bqlf72fe	252	38	the	the	DT
cord-007726-bqlf72fe	252	39	immunomodulatory	immunomodulatory	JJ
cord-007726-bqlf72fe	252	40	role	role	NN
cord-007726-bqlf72fe	252	41	of	of	IN
cord-007726-bqlf72fe	252	42	early	early	JJ
cord-007726-bqlf72fe	252	43	exposure	exposure	NN
cord-007726-bqlf72fe	252	44	to	to	IN
cord-007726-bqlf72fe	252	45	gastrointestinal	gastrointestinal	JJ
cord-007726-bqlf72fe	252	46	infection	infection	NN
cord-007726-bqlf72fe	252	47	T	t	NN
cord-007726-bqlf72fe	252	48	cell	cell	NN
cord-007726-bqlf72fe	252	49	homing	homing	NN
cord-007726-bqlf72fe	252	50	to	to	IN
cord-007726-bqlf72fe	252	51	epithelial	epithelial	JJ
cord-007726-bqlf72fe	252	52	barriers	barrier	NNS
cord-007726-bqlf72fe	252	53	in	in	IN
cord-007726-bqlf72fe	252	54	allergic	allergic	JJ
cord-007726-bqlf72fe	252	55	disease	disease	NN
cord-007726-bqlf72fe	253	1	Allergic	allergic	JJ
cord-007726-bqlf72fe	253	2	airway	airway	NN
cord-007726-bqlf72fe	253	3	inflammation	inflammation	NN
cord-007726-bqlf72fe	253	4	initiates	initiate	VBZ
cord-007726-bqlf72fe	253	5	long	long	JJ
cord-007726-bqlf72fe	253	6	-	-	HYPH
cord-007726-bqlf72fe	253	7	term	term	NN
cord-007726-bqlf72fe	253	8	vascular	vascular	JJ
cord-007726-bqlf72fe	253	9	remodeling	remodeling	NN
cord-007726-bqlf72fe	253	10	of	of	IN
cord-007726-bqlf72fe	253	11	the	the	DT
cord-007726-bqlf72fe	253	12	pulmonary	pulmonary	JJ
cord-007726-bqlf72fe	253	13	circulation	circulation	NN
cord-007726-bqlf72fe	253	14	Respiratory	respiratory	JJ
cord-007726-bqlf72fe	253	15	allergy	allergy	NN
cord-007726-bqlf72fe	253	16	caused	cause	VBN
cord-007726-bqlf72fe	253	17	by	by	IN
cord-007726-bqlf72fe	253	18	house	house	NN
cord-007726-bqlf72fe	253	19	dust	dust	NN
cord-007726-bqlf72fe	253	20	mites	mite	NNS
cord-007726-bqlf72fe	253	21	:	:	:
cord-007726-bqlf72fe	253	22	what	what	WP
cord-007726-bqlf72fe	253	23	do	do	VBP
cord-007726-bqlf72fe	253	24	we	-PRON-	PRP
cord-007726-bqlf72fe	253	25	really	really	RB
cord-007726-bqlf72fe	253	26	know	know	VB
cord-007726-bqlf72fe	253	27	?	?	.
cord-007726-bqlf72fe	254	1	Continuous	continuous	JJ
cord-007726-bqlf72fe	254	2	exposure	exposure	NN
cord-007726-bqlf72fe	254	3	to	to	IN
cord-007726-bqlf72fe	254	4	house	house	NN
cord-007726-bqlf72fe	254	5	dust	dust	NN
cord-007726-bqlf72fe	254	6	mite	mite	NNP
cord-007726-bqlf72fe	254	7	elicits	elicit	VBZ
cord-007726-bqlf72fe	254	8	chronic	chronic	JJ
cord-007726-bqlf72fe	254	9	airway	airway	NN
cord-007726-bqlf72fe	254	10	inflammation	inflammation	NN
cord-007726-bqlf72fe	254	11	and	and	CC
cord-007726-bqlf72fe	254	12	structural	structural	JJ
cord-007726-bqlf72fe	254	13	remodeling	remodeling	NN
cord-007726-bqlf72fe	254	14	Induction	Induction	NNP
cord-007726-bqlf72fe	254	15	of	of	IN
cord-007726-bqlf72fe	254	16	vascular	vascular	JJ
cord-007726-bqlf72fe	254	17	remodeling	remodeling	NN
cord-007726-bqlf72fe	254	18	in	in	IN
cord-007726-bqlf72fe	254	19	the	the	DT
cord-007726-bqlf72fe	254	20	lung	lung	NN
cord-007726-bqlf72fe	254	21	by	by	IN
cord-007726-bqlf72fe	254	22	chronic	chronic	NNP
cord-007726-bqlf72fe	254	23	house	house	NNP
cord-007726-bqlf72fe	254	24	dust	dust	NN
cord-007726-bqlf72fe	254	25	mite	mite	NNP
cord-007726-bqlf72fe	254	26	exposure	exposure	NN
cord-007726-bqlf72fe	254	27	Lung	Lung	NNP
cord-007726-bqlf72fe	254	28	responses	response	NNS
cord-007726-bqlf72fe	254	29	in	in	IN
cord-007726-bqlf72fe	254	30	murine	murine	JJ
cord-007726-bqlf72fe	254	31	models	model	NNS
cord-007726-bqlf72fe	254	32	of	of	IN
cord-007726-bqlf72fe	254	33	experimental	experimental	JJ
cord-007726-bqlf72fe	254	34	asthma	asthma	NN
cord-007726-bqlf72fe	254	35	:	:	:
cord-007726-bqlf72fe	254	36	value	value	NN
cord-007726-bqlf72fe	254	37	of	of	IN
cord-007726-bqlf72fe	254	38	house	house	NN
cord-007726-bqlf72fe	254	39	dust	dust	NN
cord-007726-bqlf72fe	254	40	mite	mite	NNP
cord-007726-bqlf72fe	254	41	over	over	IN
cord-007726-bqlf72fe	254	42	ovalbumin	ovalbumin	JJ
cord-007726-bqlf72fe	254	43	sensitization	sensitization	NN
cord-007726-bqlf72fe	254	44	A	a	DT
cord-007726-bqlf72fe	254	45	novel	novel	JJ
cord-007726-bqlf72fe	254	46	mouse	mouse	NN
cord-007726-bqlf72fe	254	47	model	model	NN
cord-007726-bqlf72fe	254	48	of	of	IN
cord-007726-bqlf72fe	254	49	experimental	experimental	JJ
cord-007726-bqlf72fe	254	50	asthma	asthma	NN
cord-007726-bqlf72fe	254	51	Temporal	temporal	JJ
cord-007726-bqlf72fe	254	52	role	role	NN
cord-007726-bqlf72fe	254	53	of	of	IN
cord-007726-bqlf72fe	254	54	chemokines	chemokine	NNS
cord-007726-bqlf72fe	254	55	in	in	IN
cord-007726-bqlf72fe	254	56	a	a	DT
cord-007726-bqlf72fe	254	57	murine	murine	JJ
cord-007726-bqlf72fe	254	58	model	model	NN
cord-007726-bqlf72fe	254	59	of	of	IN
cord-007726-bqlf72fe	254	60	cockroach	cockroach	NN
cord-007726-bqlf72fe	254	61	allergen	allergen	NN
cord-007726-bqlf72fe	254	62	-	-	HYPH
cord-007726-bqlf72fe	254	63	induced	induce	VBN
cord-007726-bqlf72fe	254	64	airway	airway	NN
cord-007726-bqlf72fe	254	65	hyperreactivity	hyperreactivity	NN
cord-007726-bqlf72fe	254	66	and	and	CC
cord-007726-bqlf72fe	254	67	eosinophilia	eosinophilia	NNP
cord-007726-bqlf72fe	254	68	Animal	Animal	NNP
cord-007726-bqlf72fe	254	69	models	model	NNS
cord-007726-bqlf72fe	254	70	of	of	IN
cord-007726-bqlf72fe	254	71	allergic	allergic	JJ
cord-007726-bqlf72fe	254	72	bronchopulmonary	bronchopulmonary	JJ
cord-007726-bqlf72fe	254	73	aspergillosis	aspergillosis	NN
cord-007726-bqlf72fe	254	74	Murine	Murine	NNP
cord-007726-bqlf72fe	254	75	models	model	NNS
cord-007726-bqlf72fe	254	76	of	of	IN
cord-007726-bqlf72fe	254	77	airway	airway	NN
cord-007726-bqlf72fe	254	78	fungal	fungal	NN
cord-007726-bqlf72fe	254	79	exposure	exposure	NN
cord-007726-bqlf72fe	254	80	and	and	CC
cord-007726-bqlf72fe	254	81	allergic	allergic	JJ
cord-007726-bqlf72fe	254	82	sensitization	sensitization	NN
cord-007726-bqlf72fe	254	83	Mouse	mouse	NN
cord-007726-bqlf72fe	254	84	models	model	NNS
cord-007726-bqlf72fe	254	85	of	of	IN
cord-007726-bqlf72fe	254	86	acute	acute	JJ
cord-007726-bqlf72fe	254	87	exacerbations	exacerbation	NNS
cord-007726-bqlf72fe	254	88	of	of	IN
cord-007726-bqlf72fe	254	89	allergic	allergic	JJ
cord-007726-bqlf72fe	254	90	asthma	asthma	NN
cord-007726-bqlf72fe	254	91	Mouse	Mouse	NNP
cord-007726-bqlf72fe	254	92	models	model	NNS
cord-007726-bqlf72fe	254	93	of	of	IN
cord-007726-bqlf72fe	254	94	severe	severe	JJ
cord-007726-bqlf72fe	254	95	asthma	asthma	NN
cord-007726-bqlf72fe	254	96	:	:	:
cord-007726-bqlf72fe	254	97	understanding	understand	VBG
cord-007726-bqlf72fe	254	98	the	the	DT
cord-007726-bqlf72fe	254	99	mechanisms	mechanism	NNS
cord-007726-bqlf72fe	254	100	of	of	IN
cord-007726-bqlf72fe	254	101	steroid	steroid	NN
cord-007726-bqlf72fe	254	102	resistance	resistance	NN
cord-007726-bqlf72fe	254	103	,	,	,
cord-007726-bqlf72fe	254	104	tissue	tissue	NN
cord-007726-bqlf72fe	254	105	remodelling	remodelling	NN
cord-007726-bqlf72fe	254	106	and	and	CC
cord-007726-bqlf72fe	254	107	disease	disease	NN
cord-007726-bqlf72fe	254	108	exacerbation	exacerbation	NN
cord-007726-bqlf72fe	254	109	Novel	Novel	NNP
cord-007726-bqlf72fe	254	110	variants	variant	NNS
cord-007726-bqlf72fe	254	111	of	of	IN
cord-007726-bqlf72fe	254	112	SER	SER	NNP
cord-007726-bqlf72fe	254	113	-	-	HYPH
cord-007726-bqlf72fe	254	114	PIN1A	pin1a	JJ
cord-007726-bqlf72fe	254	115	gene	gene	NN
cord-007726-bqlf72fe	254	116	:	:	:
cord-007726-bqlf72fe	254	117	interplay	interplay	NN
cord-007726-bqlf72fe	254	118	between	between	IN
cord-007726-bqlf72fe	254	119	alpha1-antitrypsin	alpha1-antitrypsin	JJ
cord-007726-bqlf72fe	254	120	deficiency	deficiency	NN
cord-007726-bqlf72fe	254	121	and	and	CC
cord-007726-bqlf72fe	254	122	chronic	chronic	JJ
cord-007726-bqlf72fe	254	123	obstructive	obstructive	JJ
cord-007726-bqlf72fe	254	124	pulmonary	pulmonary	JJ
cord-007726-bqlf72fe	254	125	disease	disease	NN
cord-007726-bqlf72fe	255	1	Different	different	JJ
cord-007726-bqlf72fe	255	2	lung	lung	NN
cord-007726-bqlf72fe	255	3	responses	response	NNS
cord-007726-bqlf72fe	255	4	to	to	IN
cord-007726-bqlf72fe	255	5	cigarette	cigarette	NN
cord-007726-bqlf72fe	255	6	smoke	smoke	NN
cord-007726-bqlf72fe	255	7	in	in	IN
cord-007726-bqlf72fe	255	8	two	two	CD
cord-007726-bqlf72fe	255	9	strains	strain	NNS
cord-007726-bqlf72fe	255	10	of	of	IN
cord-007726-bqlf72fe	255	11	mice	mouse	NNS
cord-007726-bqlf72fe	255	12	sensitive	sensitive	JJ
cord-007726-bqlf72fe	255	13	to	to	IN
cord-007726-bqlf72fe	255	14	oxidants	oxidant	NNS
cord-007726-bqlf72fe	255	15	Collagenase	Collagenase	NNP
cord-007726-bqlf72fe	255	16	expression	expression	NN
cord-007726-bqlf72fe	255	17	in	in	IN
cord-007726-bqlf72fe	255	18	the	the	DT
cord-007726-bqlf72fe	255	19	lungs	lung	NNS
cord-007726-bqlf72fe	255	20	of	of	IN
cord-007726-bqlf72fe	255	21	transgenic	transgenic	JJ
cord-007726-bqlf72fe	255	22	mice	mouse	NNS
cord-007726-bqlf72fe	255	23	causes	cause	VBZ
cord-007726-bqlf72fe	255	24	pulmonary	pulmonary	JJ
cord-007726-bqlf72fe	255	25	emphysema	emphysema	NN
cord-007726-bqlf72fe	255	26	Tissue	tissue	NN
cord-007726-bqlf72fe	255	27	remodelling	remodelle	VBG
cord-007726-bqlf72fe	255	28	in	in	IN
cord-007726-bqlf72fe	255	29	pulmonary	pulmonary	JJ
cord-007726-bqlf72fe	255	30	fibrosis	fibrosis	NN
cord-007726-bqlf72fe	255	31	Idiopathic	idiopathic	JJ
cord-007726-bqlf72fe	255	32	pulmonary	pulmonary	JJ
cord-007726-bqlf72fe	255	33	fibrosis	fibrosis	NN
cord-007726-bqlf72fe	255	34	Exploring	explore	VBG
cord-007726-bqlf72fe	255	35	animal	animal	NN
cord-007726-bqlf72fe	255	36	models	model	NNS
cord-007726-bqlf72fe	255	37	that	that	WDT
cord-007726-bqlf72fe	255	38	resemble	resemble	VBP
cord-007726-bqlf72fe	255	39	idiopathic	idiopathic	JJ
cord-007726-bqlf72fe	255	40	pulmonary	pulmonary	JJ
cord-007726-bqlf72fe	255	41	fibrosis	fibrosis	NN
cord-007726-bqlf72fe	256	1	The	the	DT
cord-007726-bqlf72fe	256	2	role	role	NN
cord-007726-bqlf72fe	256	3	of	of	IN
cord-007726-bqlf72fe	256	4	mouse	mouse	NN
cord-007726-bqlf72fe	256	5	strain	strain	NN
cord-007726-bqlf72fe	256	6	differences	difference	NNS
cord-007726-bqlf72fe	256	7	in	in	IN
cord-007726-bqlf72fe	256	8	the	the	DT
cord-007726-bqlf72fe	256	9	susceptibility	susceptibility	NN
cord-007726-bqlf72fe	256	10	to	to	IN
cord-007726-bqlf72fe	256	11	fibrosis	fibrosis	NN
cord-007726-bqlf72fe	256	12	:	:	:
cord-007726-bqlf72fe	256	13	a	a	DT
cord-007726-bqlf72fe	256	14	systematic	systematic	JJ
cord-007726-bqlf72fe	256	15	review	review	NN
cord-007726-bqlf72fe	256	16	Murine	murine	JJ
cord-007726-bqlf72fe	256	17	models	model	NNS
cord-007726-bqlf72fe	256	18	of	of	IN
cord-007726-bqlf72fe	256	19	pulmonary	pulmonary	JJ
cord-007726-bqlf72fe	256	20	fibrosis	fibrosis	NN
cord-007726-bqlf72fe	257	1	Highly	highly	RB
cord-007726-bqlf72fe	257	2	selective	selective	JJ
cord-007726-bqlf72fe	257	3	endothelin-1	endothelin-1	NNP
cord-007726-bqlf72fe	257	4	receptor	receptor	NN
cord-007726-bqlf72fe	258	1	A	a	DT
cord-007726-bqlf72fe	258	2	inhibition	inhibition	NN
cord-007726-bqlf72fe	258	3	prevents	prevent	VBZ
cord-007726-bqlf72fe	258	4	bleomycin	bleomycin	NN
cord-007726-bqlf72fe	258	5	-	-	HYPH
cord-007726-bqlf72fe	258	6	induced	induce	VBN
cord-007726-bqlf72fe	258	7	pulmonary	pulmonary	JJ
cord-007726-bqlf72fe	258	8	inflammation	inflammation	NN
cord-007726-bqlf72fe	258	9	and	and	CC
cord-007726-bqlf72fe	258	10	fibrosis	fibrosis	NN
cord-007726-bqlf72fe	258	11	in	in	IN
cord-007726-bqlf72fe	258	12	mice	mouse	NNS
cord-007726-bqlf72fe	258	13	(	(	-LRB-
cord-007726-bqlf72fe	258	14	R)-resolvin	R)-resolvin	NNP
cord-007726-bqlf72fe	258	15	D1	D1	NNP
cord-007726-bqlf72fe	258	16	ameliorates	ameliorate	VBZ
cord-007726-bqlf72fe	258	17	bleomycin	bleomycin	NN
cord-007726-bqlf72fe	258	18	-	-	HYPH
cord-007726-bqlf72fe	258	19	induced	induce	VBN
cord-007726-bqlf72fe	258	20	pulmonary	pulmonary	JJ
cord-007726-bqlf72fe	258	21	fibrosis	fibrosis	NN
cord-007726-bqlf72fe	258	22	in	in	IN
cord-007726-bqlf72fe	258	23	mice	mouse	NNS
cord-007726-bqlf72fe	259	1	Extracellular	Extracellular	NNP
cord-007726-bqlf72fe	259	2	matrix	matrix	NN
cord-007726-bqlf72fe	259	3	alterations	alteration	NNS
cord-007726-bqlf72fe	259	4	and	and	CC
cord-007726-bqlf72fe	259	5	acute	acute	JJ
cord-007726-bqlf72fe	259	6	inflammation	inflammation	NN
cord-007726-bqlf72fe	259	7	;	;	:
cord-007726-bqlf72fe	259	8	developing	develop	VBG
cord-007726-bqlf72fe	259	9	in	in	IN
cord-007726-bqlf72fe	259	10	parallel	parallel	NN
cord-007726-bqlf72fe	259	11	during	during	IN
cord-007726-bqlf72fe	259	12	early	early	JJ
cord-007726-bqlf72fe	259	13	induction	induction	NN
cord-007726-bqlf72fe	259	14	of	of	IN
cord-007726-bqlf72fe	259	15	pulmonary	pulmonary	JJ
cord-007726-bqlf72fe	259	16	fibrosis	fibrosis	NN
cord-007726-bqlf72fe	259	17	Smad3	Smad3	NNP
cord-007726-bqlf72fe	260	1	signaling	signal	VBG
cord-007726-bqlf72fe	260	2	involved	involve	VBN
cord-007726-bqlf72fe	260	3	in	in	IN
cord-007726-bqlf72fe	260	4	pulmonary	pulmonary	JJ
cord-007726-bqlf72fe	260	5	fibrosis	fibrosis	NN
cord-007726-bqlf72fe	260	6	and	and	CC
cord-007726-bqlf72fe	260	7	emphysema	emphysema	NN
cord-007726-bqlf72fe	260	8	Adenovector	Adenovector	NNP
cord-007726-bqlf72fe	260	9	-	-	HYPH
cord-007726-bqlf72fe	260	10	mediated	mediate	VBN
cord-007726-bqlf72fe	260	11	gene	gene	NN
cord-007726-bqlf72fe	260	12	transfer	transfer	NN
cord-007726-bqlf72fe	260	13	of	of	IN
cord-007726-bqlf72fe	260	14	active	active	JJ
cord-007726-bqlf72fe	260	15	transforming	transform	VBG
cord-007726-bqlf72fe	260	16	growth	growth	NN
cord-007726-bqlf72fe	260	17	factor	factor	NN
cord-007726-bqlf72fe	261	1	-beta1	-beta1	:
cord-007726-bqlf72fe	261	2	induces	induce	VBZ
cord-007726-bqlf72fe	261	3	prolonged	prolong	VBD
cord-007726-bqlf72fe	261	4	severe	severe	JJ
cord-007726-bqlf72fe	261	5	fibrosis	fibrosis	NN
cord-007726-bqlf72fe	261	6	in	in	IN
cord-007726-bqlf72fe	261	7	rat	rat	NN
cord-007726-bqlf72fe	261	8	lung	lung	NN
cord-007726-bqlf72fe	262	1	The	the	DT
cord-007726-bqlf72fe	262	2	ethics	ethic	NNS
cord-007726-bqlf72fe	262	3	of	of	IN
cord-007726-bqlf72fe	262	4	animal	animal	NN
cord-007726-bqlf72fe	262	5	research	research	NN
cord-007726-bqlf72fe	262	6	.	.	.
cord-007726-bqlf72fe	263	1	Talking	talk	VBG
cord-007726-bqlf72fe	263	2	Point	Point	NNP
cord-007726-bqlf72fe	263	3	on	on	IN
cord-007726-bqlf72fe	263	4	the	the	DT
cord-007726-bqlf72fe	263	5	use	use	NN
cord-007726-bqlf72fe	263	6	of	of	IN
cord-007726-bqlf72fe	263	7	animals	animal	NNS
cord-007726-bqlf72fe	263	8	in	in	IN
cord-007726-bqlf72fe	263	9	scientific	scientific	JJ
cord-007726-bqlf72fe	263	10	research	research	NN