id sid tid token lemma pos cord-266593-hmx2wy1p 1 1 key key NN cord-266593-hmx2wy1p 1 2 : : : cord-266593-hmx2wy1p 2 1 cord-266593-hmx2wy1p cord-266593-hmx2wy1p NNP cord-266593-hmx2wy1p 2 2 authors author NNS cord-266593-hmx2wy1p 2 3 : : : cord-266593-hmx2wy1p 2 4 Cope cope VB cord-266593-hmx2wy1p 2 5 , , , cord-266593-hmx2wy1p 2 6 Robert Robert NNP cord-266593-hmx2wy1p 2 7 C. C. NNP cord-266593-hmx2wy1p 2 8 ; ; : cord-266593-hmx2wy1p 2 9 Ross Ross NNP cord-266593-hmx2wy1p 2 10 , , , cord-266593-hmx2wy1p 2 11 Joshua Joshua NNP cord-266593-hmx2wy1p 2 12 V. V. NNP cord-266593-hmx2wy1p 2 13 title title NN cord-266593-hmx2wy1p 2 14 : : : cord-266593-hmx2wy1p 2 15 Identification identification NN cord-266593-hmx2wy1p 2 16 of of IN cord-266593-hmx2wy1p 2 17 the the DT cord-266593-hmx2wy1p 2 18 relative relative JJ cord-266593-hmx2wy1p 2 19 timing timing NN cord-266593-hmx2wy1p 2 20 of of IN cord-266593-hmx2wy1p 2 21 infectiousness infectiousness NN cord-266593-hmx2wy1p 2 22 and and CC cord-266593-hmx2wy1p 2 23 symptom symptom NN cord-266593-hmx2wy1p 2 24 onset onset NN cord-266593-hmx2wy1p 2 25 for for IN cord-266593-hmx2wy1p 2 26 outbreak outbreak NN cord-266593-hmx2wy1p 2 27 control control NN cord-266593-hmx2wy1p 2 28 date date NN cord-266593-hmx2wy1p 2 29 : : : cord-266593-hmx2wy1p 2 30 2020 2020 CD cord-266593-hmx2wy1p 2 31 - - HYPH cord-266593-hmx2wy1p 2 32 02 02 CD cord-266593-hmx2wy1p 2 33 - - HYPH cord-266593-hmx2wy1p 2 34 07 07 CD cord-266593-hmx2wy1p 2 35 journal journal NN cord-266593-hmx2wy1p 2 36 : : : cord-266593-hmx2wy1p 2 37 Journal Journal NNP cord-266593-hmx2wy1p 2 38 of of IN cord-266593-hmx2wy1p 2 39 Theoretical Theoretical NNP cord-266593-hmx2wy1p 2 40 Biology Biology NNP cord-266593-hmx2wy1p 2 41 DOI doi NN cord-266593-hmx2wy1p 2 42 : : : cord-266593-hmx2wy1p 2 43 10.1016/ 10.1016/ CD cord-266593-hmx2wy1p 3 1 j.jtbi.2019.110079 j.jtbi.2019.110079 NNP cord-266593-hmx2wy1p 4 1 sha sha NNP cord-266593-hmx2wy1p 4 2 : : : cord-266593-hmx2wy1p 5 1 91a7bdeba621745d246ebd38599661945603acbb 91a7bdeba621745d246ebd38599661945603acbb CD cord-266593-hmx2wy1p 5 2 doc_id doc_id CD cord-266593-hmx2wy1p 5 3 : : : cord-266593-hmx2wy1p 5 4 266593 266593 CD cord-266593-hmx2wy1p 5 5 cord_uid cord_uid NNS cord-266593-hmx2wy1p 5 6 : : : cord-266593-hmx2wy1p 5 7 hmx2wy1p hmx2wy1p ADD cord-266593-hmx2wy1p 5 8 Abstract Abstract NNP cord-266593-hmx2wy1p 6 1 In in IN cord-266593-hmx2wy1p 6 2 an an DT cord-266593-hmx2wy1p 6 3 outbreak outbreak NN cord-266593-hmx2wy1p 6 4 of of IN cord-266593-hmx2wy1p 6 5 an an DT cord-266593-hmx2wy1p 6 6 emerging emerge VBG cord-266593-hmx2wy1p 6 7 disease disease NN cord-266593-hmx2wy1p 6 8 the the DT cord-266593-hmx2wy1p 6 9 epidemiological epidemiological JJ cord-266593-hmx2wy1p 6 10 characteristics characteristic NNS cord-266593-hmx2wy1p 6 11 of of IN cord-266593-hmx2wy1p 6 12 the the DT cord-266593-hmx2wy1p 6 13 pathogen pathogen NN cord-266593-hmx2wy1p 6 14 may may MD cord-266593-hmx2wy1p 6 15 be be VB cord-266593-hmx2wy1p 6 16 largely largely RB cord-266593-hmx2wy1p 6 17 unknown unknown JJ cord-266593-hmx2wy1p 6 18 . . . cord-266593-hmx2wy1p 7 1 A a DT cord-266593-hmx2wy1p 7 2 key key JJ cord-266593-hmx2wy1p 7 3 determinant determinant NN cord-266593-hmx2wy1p 7 4 of of IN cord-266593-hmx2wy1p 7 5 ability ability NN cord-266593-hmx2wy1p 7 6 to to TO cord-266593-hmx2wy1p 7 7 control control VB cord-266593-hmx2wy1p 7 8 the the DT cord-266593-hmx2wy1p 7 9 outbreak outbreak NN cord-266593-hmx2wy1p 7 10 is be VBZ cord-266593-hmx2wy1p 7 11 the the DT cord-266593-hmx2wy1p 7 12 relative relative JJ cord-266593-hmx2wy1p 7 13 timing timing NN cord-266593-hmx2wy1p 7 14 of of IN cord-266593-hmx2wy1p 7 15 infectiousness infectiousness NN cord-266593-hmx2wy1p 7 16 and and CC cord-266593-hmx2wy1p 7 17 symptom symptom NN cord-266593-hmx2wy1p 7 18 onset onset NN cord-266593-hmx2wy1p 7 19 . . . cord-266593-hmx2wy1p 8 1 We -PRON- PRP cord-266593-hmx2wy1p 8 2 provide provide VBP cord-266593-hmx2wy1p 8 3 a a DT cord-266593-hmx2wy1p 8 4 method method NN cord-266593-hmx2wy1p 8 5 for for IN cord-266593-hmx2wy1p 8 6 identifying identify VBG cord-266593-hmx2wy1p 8 7 this this DT cord-266593-hmx2wy1p 8 8 relationship relationship NN cord-266593-hmx2wy1p 8 9 with with IN cord-266593-hmx2wy1p 8 10 high high JJ cord-266593-hmx2wy1p 8 11 accuracy accuracy NN cord-266593-hmx2wy1p 8 12 based base VBN cord-266593-hmx2wy1p 8 13 on on IN cord-266593-hmx2wy1p 8 14 data datum NNS cord-266593-hmx2wy1p 8 15 from from IN cord-266593-hmx2wy1p 8 16 simulated simulated JJ cord-266593-hmx2wy1p 8 17 household household NN cord-266593-hmx2wy1p 8 18 - - HYPH cord-266593-hmx2wy1p 8 19 stratified stratify VBN cord-266593-hmx2wy1p 8 20 symptom symptom NN cord-266593-hmx2wy1p 8 21 - - HYPH cord-266593-hmx2wy1p 8 22 onset onset NN cord-266593-hmx2wy1p 8 23 data datum NNS cord-266593-hmx2wy1p 8 24 . . . cord-266593-hmx2wy1p 9 1 Further further RB cord-266593-hmx2wy1p 9 2 , , , cord-266593-hmx2wy1p 9 3 this this DT cord-266593-hmx2wy1p 9 4 can can MD cord-266593-hmx2wy1p 9 5 be be VB cord-266593-hmx2wy1p 9 6 achieved achieve VBN cord-266593-hmx2wy1p 9 7 with with IN cord-266593-hmx2wy1p 9 8 observations observation NNS cord-266593-hmx2wy1p 9 9 taken take VBN cord-266593-hmx2wy1p 9 10 on on RP cord-266593-hmx2wy1p 9 11 only only RB cord-266593-hmx2wy1p 9 12 a a DT cord-266593-hmx2wy1p 9 13 few few JJ cord-266593-hmx2wy1p 9 14 specific specific JJ cord-266593-hmx2wy1p 9 15 days day NNS cord-266593-hmx2wy1p 9 16 , , , cord-266593-hmx2wy1p 9 17 chosen choose VBN cord-266593-hmx2wy1p 9 18 optimally optimally RB cord-266593-hmx2wy1p 9 19 , , , cord-266593-hmx2wy1p 9 20 within within IN cord-266593-hmx2wy1p 9 21 each each DT cord-266593-hmx2wy1p 9 22 household household NN cord-266593-hmx2wy1p 9 23 . . . cord-266593-hmx2wy1p 10 1 The the DT cord-266593-hmx2wy1p 10 2 information information NN cord-266593-hmx2wy1p 10 3 provided provide VBN cord-266593-hmx2wy1p 10 4 by by IN cord-266593-hmx2wy1p 10 5 this this DT cord-266593-hmx2wy1p 10 6 method method NN cord-266593-hmx2wy1p 10 7 may may MD cord-266593-hmx2wy1p 10 8 inform inform VB cord-266593-hmx2wy1p 10 9 decision decision NN cord-266593-hmx2wy1p 10 10 making make VBG cord-266593-hmx2wy1p 10 11 processes process NNS cord-266593-hmx2wy1p 10 12 for for IN cord-266593-hmx2wy1p 10 13 outbreak outbreak NN cord-266593-hmx2wy1p 10 14 response response NN cord-266593-hmx2wy1p 10 15 . . . cord-266593-hmx2wy1p 11 1 An an DT cord-266593-hmx2wy1p 11 2 accurate accurate JJ cord-266593-hmx2wy1p 11 3 and and CC cord-266593-hmx2wy1p 11 4 computationally computationally RB cord-266593-hmx2wy1p 11 5 - - HYPH cord-266593-hmx2wy1p 11 6 efficient efficient JJ cord-266593-hmx2wy1p 11 7 heuristic heuristic NN cord-266593-hmx2wy1p 11 8 for for IN cord-266593-hmx2wy1p 11 9 determining determine VBG cord-266593-hmx2wy1p 11 10 the the DT cord-266593-hmx2wy1p 11 11 optimal optimal JJ cord-266593-hmx2wy1p 11 12 surveillance surveillance NN cord-266593-hmx2wy1p 11 13 scheme scheme NN cord-266593-hmx2wy1p 11 14 is be VBZ cord-266593-hmx2wy1p 11 15 introduced introduce VBN cord-266593-hmx2wy1p 11 16 . . . cord-266593-hmx2wy1p 12 1 This this DT cord-266593-hmx2wy1p 12 2 heuristic heuristic NN cord-266593-hmx2wy1p 12 3 provides provide VBZ cord-266593-hmx2wy1p 12 4 a a DT cord-266593-hmx2wy1p 12 5 novel novel JJ cord-266593-hmx2wy1p 12 6 approach approach NN cord-266593-hmx2wy1p 12 7 to to IN cord-266593-hmx2wy1p 12 8 optimal optimal JJ cord-266593-hmx2wy1p 12 9 design design NN cord-266593-hmx2wy1p 12 10 for for IN cord-266593-hmx2wy1p 12 11 Bayesian bayesian JJ cord-266593-hmx2wy1p 12 12 model model NN cord-266593-hmx2wy1p 12 13 discrimination discrimination NN cord-266593-hmx2wy1p 12 14 . . . cord-266593-hmx2wy1p 13 1 The the DT cord-266593-hmx2wy1p 13 2 timing timing NN cord-266593-hmx2wy1p 13 3 of of IN cord-266593-hmx2wy1p 13 4 infectiousness infectiousness NN cord-266593-hmx2wy1p 13 5 relative relative JJ cord-266593-hmx2wy1p 13 6 to to IN cord-266593-hmx2wy1p 13 7 symptom symptom NN cord-266593-hmx2wy1p 13 8 onset onset NN cord-266593-hmx2wy1p 13 9 has have VBZ cord-266593-hmx2wy1p 13 10 been be VBN cord-266593-hmx2wy1p 13 11 identified identify VBN cord-266593-hmx2wy1p 13 12 as as IN cord-266593-hmx2wy1p 13 13 a a DT cord-266593-hmx2wy1p 13 14 key key JJ cord-266593-hmx2wy1p 13 15 factor factor NN cord-266593-hmx2wy1p 13 16 in in IN cord-266593-hmx2wy1p 13 17 ability ability NN cord-266593-hmx2wy1p 13 18 to to TO cord-266593-hmx2wy1p 13 19 control control VB cord-266593-hmx2wy1p 13 20 an an DT cord-266593-hmx2wy1p 13 21 outbreak outbreak NN cord-266593-hmx2wy1p 13 22 . . . cord-266593-hmx2wy1p 14 1 The the DT cord-266593-hmx2wy1p 14 2 explanation explanation NN cord-266593-hmx2wy1p 14 3 is be VBZ cord-266593-hmx2wy1p 14 4 intuitive intuitive JJ cord-266593-hmx2wy1p 14 5 : : : cord-266593-hmx2wy1p 14 6 if if IN cord-266593-hmx2wy1p 14 7 symptoms symptom NNS cord-266593-hmx2wy1p 14 8 appear appear VBP cord-266593-hmx2wy1p 14 9 before before IN cord-266593-hmx2wy1p 14 10 infectiousness infectiousness NN cord-266593-hmx2wy1p 14 11 , , , cord-266593-hmx2wy1p 14 12 then then RB cord-266593-hmx2wy1p 14 13 contact contact NN cord-266593-hmx2wy1p 14 14 tracing tracing NN cord-266593-hmx2wy1p 14 15 and and CC cord-266593-hmx2wy1p 14 16 isolation isolation NN cord-266593-hmx2wy1p 14 17 strategies strategy NNS cord-266593-hmx2wy1p 14 18 will will MD cord-266593-hmx2wy1p 14 19 be be VB cord-266593-hmx2wy1p 14 20 effective effective JJ cord-266593-hmx2wy1p 14 21 , , , cord-266593-hmx2wy1p 14 22 whereas whereas IN cord-266593-hmx2wy1p 14 23 for for IN cord-266593-hmx2wy1p 14 24 post post JJ cord-266593-hmx2wy1p 14 25 - - JJ cord-266593-hmx2wy1p 14 26 infectiousness infectiousness JJ cord-266593-hmx2wy1p 14 27 symptom symptom NN cord-266593-hmx2wy1p 14 28 presentation presentation NN cord-266593-hmx2wy1p 14 29 , , , cord-266593-hmx2wy1p 14 30 broader broad JJR cord-266593-hmx2wy1p 14 31 , , , cord-266593-hmx2wy1p 14 32 non non JJ cord-266593-hmx2wy1p 14 33 - - JJ cord-266593-hmx2wy1p 14 34 symptom symptom JJ cord-266593-hmx2wy1p 14 35 based base VBN cord-266593-hmx2wy1p 14 36 strategies strategy NNS cord-266593-hmx2wy1p 14 37 must must MD cord-266593-hmx2wy1p 14 38 be be VB cord-266593-hmx2wy1p 14 39 adopted adopt VBN cord-266593-hmx2wy1p 14 40 . . . cord-266593-hmx2wy1p 15 1 Consequently consequently RB cord-266593-hmx2wy1p 15 2 , , , cord-266593-hmx2wy1p 15 3 identifying identify VBG cord-266593-hmx2wy1p 15 4 the the DT cord-266593-hmx2wy1p 15 5 relative relative JJ cord-266593-hmx2wy1p 15 6 timing timing NN cord-266593-hmx2wy1p 15 7 as as RB cord-266593-hmx2wy1p 15 8 early early RB cord-266593-hmx2wy1p 15 9 as as IN cord-266593-hmx2wy1p 15 10 possible possible JJ cord-266593-hmx2wy1p 15 11 in in IN cord-266593-hmx2wy1p 15 12 an an DT cord-266593-hmx2wy1p 15 13 outbreak outbreak NN cord-266593-hmx2wy1p 15 14 is be VBZ cord-266593-hmx2wy1p 15 15 imperative imperative JJ cord-266593-hmx2wy1p 15 16 to to IN cord-266593-hmx2wy1p 15 17 assessing assess VBG cord-266593-hmx2wy1p 15 18 potential potential NN cord-266593-hmx2wy1p 15 19 for for IN cord-266593-hmx2wy1p 15 20 control control NN cord-266593-hmx2wy1p 15 21 and and CC cord-266593-hmx2wy1p 15 22 selecting select VBG cord-266593-hmx2wy1p 15 23 a a DT cord-266593-hmx2wy1p 15 24 measured measure VBN cord-266593-hmx2wy1p 15 25 response response NN cord-266593-hmx2wy1p 15 26 . . . cord-266593-hmx2wy1p 16 1 Severe severe JJ cord-266593-hmx2wy1p 16 2 acute acute JJ cord-266593-hmx2wy1p 16 3 respiratory respiratory JJ cord-266593-hmx2wy1p 16 4 syndrome syndrome NN cord-266593-hmx2wy1p 16 5 ( ( -LRB- cord-266593-hmx2wy1p 16 6 SARS SARS NNP cord-266593-hmx2wy1p 16 7 ) ) -RRB- cord-266593-hmx2wy1p 16 8 is be VBZ cord-266593-hmx2wy1p 16 9 a a DT cord-266593-hmx2wy1p 16 10 prime prime JJ cord-266593-hmx2wy1p 16 11 example example NN cord-266593-hmx2wy1p 16 12 of of IN cord-266593-hmx2wy1p 16 13 a a DT cord-266593-hmx2wy1p 16 14 disease disease NN cord-266593-hmx2wy1p 16 15 in in IN cord-266593-hmx2wy1p 16 16 which which WDT cord-266593-hmx2wy1p 16 17 symptoms symptom NNS cord-266593-hmx2wy1p 16 18 foreshadow foreshadow VBP cord-266593-hmx2wy1p 16 19 significant significant JJ cord-266593-hmx2wy1p 16 20 levels level NNS cord-266593-hmx2wy1p 16 21 of of IN cord-266593-hmx2wy1p 16 22 infectiousness infectiousness NN cord-266593-hmx2wy1p 16 23 . . . cord-266593-hmx2wy1p 17 1 This this DT cord-266593-hmx2wy1p 17 2 played play VBD cord-266593-hmx2wy1p 17 3 a a DT cord-266593-hmx2wy1p 17 4 critical critical JJ cord-266593-hmx2wy1p 17 5 role role NN cord-266593-hmx2wy1p 17 6 in in IN cord-266593-hmx2wy1p 17 7 limiting limit VBG cord-266593-hmx2wy1p 17 8 mortality mortality NN cord-266593-hmx2wy1p 17 9 and and CC cord-266593-hmx2wy1p 17 10 morbidity morbidity NN cord-266593-hmx2wy1p 17 11 in in IN cord-266593-hmx2wy1p 17 12 outbreaks outbreak NNS cord-266593-hmx2wy1p 17 13 during during IN cord-266593-hmx2wy1p 17 14 2003 2003 CD cord-266593-hmx2wy1p 17 15 , , , cord-266593-hmx2wy1p 17 16 via via IN cord-266593-hmx2wy1p 17 17 simple simple JJ cord-266593-hmx2wy1p 17 18 public public JJ cord-266593-hmx2wy1p 17 19 health health NN cord-266593-hmx2wy1p 17 20 measures measure NNS cord-266593-hmx2wy1p 17 21 such such JJ cord-266593-hmx2wy1p 17 22 as as IN cord-266593-hmx2wy1p 17 23 isolation isolation NN cord-266593-hmx2wy1p 17 24 and and CC cord-266593-hmx2wy1p 17 25 quarantining quarantine VBG cord-266593-hmx2wy1p 17 26 ( ( -LRB- cord-266593-hmx2wy1p 17 27 Ksiazek Ksiazek NNP cord-266593-hmx2wy1p 17 28 et et NNP cord-266593-hmx2wy1p 17 29 al al NNP cord-266593-hmx2wy1p 17 30 . . . cord-266593-hmx2wy1p 18 1 , , , cord-266593-hmx2wy1p 18 2 2003 2003 CD cord-266593-hmx2wy1p 18 3 ; ; : cord-266593-hmx2wy1p 18 4 Lee Lee NNP cord-266593-hmx2wy1p 18 5 et et NNP cord-266593-hmx2wy1p 18 6 al al NNP cord-266593-hmx2wy1p 18 7 . . NNP cord-266593-hmx2wy1p 18 8 , , , cord-266593-hmx2wy1p 18 9 2003 2003 CD cord-266593-hmx2wy1p 18 10 ; ; : cord-266593-hmx2wy1p 18 11 Fraser Fraser NNP cord-266593-hmx2wy1p 18 12 et et NNP cord-266593-hmx2wy1p 18 13 al al NNP cord-266593-hmx2wy1p 18 14 . . NNP cord-266593-hmx2wy1p 18 15 , , , cord-266593-hmx2wy1p 18 16 2004 2004 CD cord-266593-hmx2wy1p 19 1 ; ; : cord-266593-hmx2wy1p 19 2 Anderson Anderson NNP cord-266593-hmx2wy1p 19 3 et et NNP cord-266593-hmx2wy1p 19 4 al al NNP cord-266593-hmx2wy1p 19 5 . . NNP cord-266593-hmx2wy1p 19 6 , , , cord-266593-hmx2wy1p 19 7 2004 2004 CD cord-266593-hmx2wy1p 19 8 ; ; : cord-266593-hmx2wy1p 19 9 Hsieh Hsieh NNP cord-266593-hmx2wy1p 19 10 et et NNP cord-266593-hmx2wy1p 19 11 al al NNP cord-266593-hmx2wy1p 19 12 . . . cord-266593-hmx2wy1p 20 1 , , , cord-266593-hmx2wy1p 20 2 2005 2005 CD cord-266593-hmx2wy1p 20 3 ; ; : cord-266593-hmx2wy1p 20 4 Day Day NNP cord-266593-hmx2wy1p 20 5 et et NNP cord-266593-hmx2wy1p 20 6 al al NNP cord-266593-hmx2wy1p 20 7 . . NNP cord-266593-hmx2wy1p 20 8 , , , cord-266593-hmx2wy1p 20 9 2006 2006 CD cord-266593-hmx2wy1p 20 10 ) ) -RRB- cord-266593-hmx2wy1p 20 11 . . . cord-266593-hmx2wy1p 21 1 Smallpox smallpox NN cord-266593-hmx2wy1p 21 2 is be VBZ cord-266593-hmx2wy1p 21 3 most most RBS cord-266593-hmx2wy1p 21 4 similar similar JJ cord-266593-hmx2wy1p 21 5 to to IN cord-266593-hmx2wy1p 21 6 SARS SARS NNP cord-266593-hmx2wy1p 21 7 in in IN cord-266593-hmx2wy1p 21 8 this this DT cord-266593-hmx2wy1p 21 9 respect respect NN cord-266593-hmx2wy1p 21 10 , , , cord-266593-hmx2wy1p 21 11 but but CC cord-266593-hmx2wy1p 21 12 must must MD cord-266593-hmx2wy1p 21 13 be be VB cord-266593-hmx2wy1p 21 14 contrasted contrast VBN cord-266593-hmx2wy1p 21 15 with with IN cord-266593-hmx2wy1p 21 16 HIV HIV NNP cord-266593-hmx2wy1p 21 17 , , , cord-266593-hmx2wy1p 21 18 where where WRB cord-266593-hmx2wy1p 21 19 a a DT cord-266593-hmx2wy1p 21 20 large large JJ cord-266593-hmx2wy1p 21 21 proportion proportion NN cord-266593-hmx2wy1p 21 22 of of IN cord-266593-hmx2wy1p 21 23 secondary secondary JJ cord-266593-hmx2wy1p 21 24 infections infection NNS cord-266593-hmx2wy1p 21 25 occur occur VBP cord-266593-hmx2wy1p 21 26 before before IN cord-266593-hmx2wy1p 21 27 symptoms symptom NNS cord-266593-hmx2wy1p 21 28 . . . cord-266593-hmx2wy1p 22 1 For for IN cord-266593-hmx2wy1p 22 2 influenza influenza NN cord-266593-hmx2wy1p 22 3 , , , cord-266593-hmx2wy1p 22 4 the the DT cord-266593-hmx2wy1p 22 5 relationship relationship NN cord-266593-hmx2wy1p 22 6 is be VBZ cord-266593-hmx2wy1p 22 7 less less RBR cord-266593-hmx2wy1p 22 8 clear clear JJ cord-266593-hmx2wy1p 22 9 , , , cord-266593-hmx2wy1p 22 10 with with IN cord-266593-hmx2wy1p 22 11 symptoms symptom NNS cord-266593-hmx2wy1p 22 12 and and CC cord-266593-hmx2wy1p 22 13 infectiousness infectiousness NN cord-266593-hmx2wy1p 22 14 likely likely RB cord-266593-hmx2wy1p 22 15 coinciding coincide VBG cord-266593-hmx2wy1p 22 16 closely closely RB cord-266593-hmx2wy1p 22 17 , , , cord-266593-hmx2wy1p 22 18 with with IN cord-266593-hmx2wy1p 22 19 some some DT cord-266593-hmx2wy1p 22 20 transmission transmission NN cord-266593-hmx2wy1p 22 21 possible possible JJ cord-266593-hmx2wy1p 22 22 before before IN cord-266593-hmx2wy1p 22 23 symptom symptom NN cord-266593-hmx2wy1p 22 24 onset onset NN cord-266593-hmx2wy1p 22 25 ( ( -LRB- cord-266593-hmx2wy1p 22 26 Patrozou Patrozou NNP cord-266593-hmx2wy1p 22 27 and and CC cord-266593-hmx2wy1p 22 28 Mermel Mermel NNP cord-266593-hmx2wy1p 22 29 , , , cord-266593-hmx2wy1p 22 30 2009 2009 CD cord-266593-hmx2wy1p 22 31 ; ; : cord-266593-hmx2wy1p 22 32 Lau Lau NNP cord-266593-hmx2wy1p 22 33 et et NNP cord-266593-hmx2wy1p 22 34 al al NNP cord-266593-hmx2wy1p 22 35 . . NNP cord-266593-hmx2wy1p 22 36 , , , cord-266593-hmx2wy1p 22 37 2010 2010 CD cord-266593-hmx2wy1p 22 38 ) ) -RRB- cord-266593-hmx2wy1p 22 39 . . . cord-266593-hmx2wy1p 23 1 For for IN cord-266593-hmx2wy1p 23 2 established establish VBN cord-266593-hmx2wy1p 23 3 diseases disease NNS cord-266593-hmx2wy1p 23 4 , , , cord-266593-hmx2wy1p 23 5 experimental experimental JJ cord-266593-hmx2wy1p 23 6 evidence evidence NN cord-266593-hmx2wy1p 23 7 ( ( -LRB- cord-266593-hmx2wy1p 23 8 Charleston Charleston NNP cord-266593-hmx2wy1p 23 9 et et NNP cord-266593-hmx2wy1p 23 10 al al NNP cord-266593-hmx2wy1p 23 11 . . NNP cord-266593-hmx2wy1p 23 12 , , , cord-266593-hmx2wy1p 23 13 2011 2011 CD cord-266593-hmx2wy1p 23 14 ) ) -RRB- cord-266593-hmx2wy1p 23 15 or or CC cord-266593-hmx2wy1p 24 1 large- large- NNP cord-266593-hmx2wy1p 24 2 * * NFP cord-266593-hmx2wy1p 24 3 Corresponding correspond VBG cord-266593-hmx2wy1p 24 4 author author NN cord-266593-hmx2wy1p 24 5 . . . cord-266593-hmx2wy1p 25 1 E e NN cord-266593-hmx2wy1p 25 2 - - NN cord-266593-hmx2wy1p 25 3 mail mail NN cord-266593-hmx2wy1p 25 4 address address NN cord-266593-hmx2wy1p 25 5 : : : cord-266593-hmx2wy1p 25 6 joshua.ross@adelaide.edu.au joshua.ross@adelaide.edu.au NNP cord-266593-hmx2wy1p 25 7 ( ( -LRB- cord-266593-hmx2wy1p 26 1 J.V. J.V. NNP cord-266593-hmx2wy1p 26 2 Ross Ross NNP cord-266593-hmx2wy1p 26 3 ) ) -RRB- cord-266593-hmx2wy1p 26 4 . . . cord-266593-hmx2wy1p 27 1 scale scale VB cord-266593-hmx2wy1p 27 2 detailed detailed JJ cord-266593-hmx2wy1p 27 3 case case NN cord-266593-hmx2wy1p 27 4 information information NN cord-266593-hmx2wy1p 27 5 ( ( -LRB- cord-266593-hmx2wy1p 27 6 International International NNP cord-266593-hmx2wy1p 27 7 Ebola Ebola NNP cord-266593-hmx2wy1p 27 8 Response Response NNP cord-266593-hmx2wy1p 27 9 Team Team NNP cord-266593-hmx2wy1p 27 10 et et NNP cord-266593-hmx2wy1p 27 11 al al NNP cord-266593-hmx2wy1p 27 12 . . NNP cord-266593-hmx2wy1p 27 13 , , , cord-266593-hmx2wy1p 27 14 2016 2016 CD cord-266593-hmx2wy1p 27 15 ) ) -RRB- cord-266593-hmx2wy1p 27 16 can can MD cord-266593-hmx2wy1p 27 17 provide provide VB cord-266593-hmx2wy1p 27 18 insight insight NN cord-266593-hmx2wy1p 27 19 into into IN cord-266593-hmx2wy1p 27 20 the the DT cord-266593-hmx2wy1p 27 21 relative relative JJ cord-266593-hmx2wy1p 27 22 timing timing NN cord-266593-hmx2wy1p 27 23 of of IN cord-266593-hmx2wy1p 27 24 symptom symptom NN cord-266593-hmx2wy1p 27 25 onset onset NN cord-266593-hmx2wy1p 27 26 and and CC cord-266593-hmx2wy1p 27 27 infectiousness infectiousness NN cord-266593-hmx2wy1p 27 28 ; ; : cord-266593-hmx2wy1p 27 29 however however RB cord-266593-hmx2wy1p 27 30 , , , cord-266593-hmx2wy1p 27 31 this this DT cord-266593-hmx2wy1p 27 32 relationship relationship NN cord-266593-hmx2wy1p 27 33 will will MD cord-266593-hmx2wy1p 27 34 not not RB cord-266593-hmx2wy1p 27 35 be be VB cord-266593-hmx2wy1p 27 36 known know VBN cord-266593-hmx2wy1p 27 37 in in IN cord-266593-hmx2wy1p 27 38 an an DT cord-266593-hmx2wy1p 27 39 outbreak outbreak NN cord-266593-hmx2wy1p 27 40 of of IN cord-266593-hmx2wy1p 27 41 an an DT cord-266593-hmx2wy1p 27 42 emerging emerge VBG cord-266593-hmx2wy1p 27 43 pathogen pathogen NN cord-266593-hmx2wy1p 27 44 . . . cord-266593-hmx2wy1p 28 1 Therefore therefore RB cord-266593-hmx2wy1p 28 2 , , , cord-266593-hmx2wy1p 28 3 one one PRP cord-266593-hmx2wy1p 28 4 must must MD cord-266593-hmx2wy1p 28 5 turn turn VB cord-266593-hmx2wy1p 28 6 to to IN cord-266593-hmx2wy1p 28 7 early early JJ cord-266593-hmx2wy1p 28 8 outbreak outbreak NN cord-266593-hmx2wy1p 28 9 surveillance surveillance NN cord-266593-hmx2wy1p 28 10 data datum NNS cord-266593-hmx2wy1p 28 11 for for IN cord-266593-hmx2wy1p 28 12 insights insight NNS cord-266593-hmx2wy1p 28 13 . . . cord-266593-hmx2wy1p 29 1 Many many JJ cord-266593-hmx2wy1p 29 2 jurisdictions jurisdiction NNS cord-266593-hmx2wy1p 29 3 organize organize VBP cord-266593-hmx2wy1p 29 4 their -PRON- PRP$ cord-266593-hmx2wy1p 29 5 emerging emerge VBG cord-266593-hmx2wy1p 29 6 disease disease NN cord-266593-hmx2wy1p 29 7 monitoring monitor VBG cord-266593-hmx2wy1p 29 8 policies policy NNS cord-266593-hmx2wy1p 29 9 around around IN cord-266593-hmx2wy1p 29 10 households household NNS cord-266593-hmx2wy1p 29 11 . . . cord-266593-hmx2wy1p 30 1 As as IN cord-266593-hmx2wy1p 30 2 an an DT cord-266593-hmx2wy1p 30 3 example example NN cord-266593-hmx2wy1p 30 4 , , , cord-266593-hmx2wy1p 30 5 First First NNP cord-266593-hmx2wy1p 30 6 Few few JJ cord-266593-hmx2wy1p 30 7 Hundred hundred CD cord-266593-hmx2wy1p 30 8 studies study NNS cord-266593-hmx2wy1p 30 9 are be VBP cord-266593-hmx2wy1p 30 10 proposed propose VBN cord-266593-hmx2wy1p 30 11 as as IN cord-266593-hmx2wy1p 30 12 a a DT cord-266593-hmx2wy1p 30 13 first first JJ cord-266593-hmx2wy1p 30 14 response response NN cord-266593-hmx2wy1p 30 15 surveillance surveillance NN cord-266593-hmx2wy1p 30 16 scheme scheme NN cord-266593-hmx2wy1p 30 17 following follow VBG cord-266593-hmx2wy1p 30 18 the the DT cord-266593-hmx2wy1p 30 19 identification identification NN cord-266593-hmx2wy1p 30 20 of of IN cord-266593-hmx2wy1p 30 21 a a DT cord-266593-hmx2wy1p 30 22 novel novel JJ cord-266593-hmx2wy1p 30 23 disease disease NN cord-266593-hmx2wy1p 30 24 and/or and/or CC cord-266593-hmx2wy1p 30 25 strain strain NN cord-266593-hmx2wy1p 30 26 as as IN cord-266593-hmx2wy1p 30 27 part part NN cord-266593-hmx2wy1p 30 28 of of IN cord-266593-hmx2wy1p 30 29 national national JJ cord-266593-hmx2wy1p 30 30 pandemic pandemic NN cord-266593-hmx2wy1p 30 31 plans plan NNS cord-266593-hmx2wy1p 30 32 ( ( -LRB- cord-266593-hmx2wy1p 31 1 McLean McLean NNP cord-266593-hmx2wy1p 31 2 et et NNP cord-266593-hmx2wy1p 31 3 al al NNP cord-266593-hmx2wy1p 31 4 . . . cord-266593-hmx2wy1p 32 1 , , , cord-266593-hmx2wy1p 32 2 2010 2010 CD cord-266593-hmx2wy1p 32 3 ; ; : cord-266593-hmx2wy1p 32 4 van van NNP cord-266593-hmx2wy1p 32 5 Gageldonk Gageldonk NNP cord-266593-hmx2wy1p 32 6 - - HYPH cord-266593-hmx2wy1p 32 7 Lafeber Lafeber NNP cord-266593-hmx2wy1p 32 8 et et NNP cord-266593-hmx2wy1p 32 9 al al NNP cord-266593-hmx2wy1p 32 10 . . NNP cord-266593-hmx2wy1p 32 11 , , , cord-266593-hmx2wy1p 32 12 2012 2012 CD cord-266593-hmx2wy1p 32 13 ; ; : cord-266593-hmx2wy1p 32 14 AHMPPI AHMPPI NNP cord-266593-hmx2wy1p 32 15 , , , cord-266593-hmx2wy1p 32 16 2014 2014 CD cord-266593-hmx2wy1p 32 17 ) ) -RRB- cord-266593-hmx2wy1p 32 18 . . . cord-266593-hmx2wy1p 33 1 Following follow VBG cord-266593-hmx2wy1p 33 2 the the DT cord-266593-hmx2wy1p 33 3 observation observation NN cord-266593-hmx2wy1p 33 4 of of IN cord-266593-hmx2wy1p 33 5 a a DT cord-266593-hmx2wy1p 33 6 first first JJ cord-266593-hmx2wy1p 33 7 symptomatic symptomatic JJ cord-266593-hmx2wy1p 33 8 individual individual NN cord-266593-hmx2wy1p 33 9 , , , cord-266593-hmx2wy1p 33 10 their -PRON- PRP$ cord-266593-hmx2wy1p 33 11 household household NN cord-266593-hmx2wy1p 33 12 is be VBZ cord-266593-hmx2wy1p 33 13 enrolled enrol VBN cord-266593-hmx2wy1p 33 14 in in IN cord-266593-hmx2wy1p 33 15 an an DT cord-266593-hmx2wy1p 33 16 intensive intensive JJ cord-266593-hmx2wy1p 33 17 surveillance surveillance NN cord-266593-hmx2wy1p 33 18 program program NN cord-266593-hmx2wy1p 33 19 , , , cord-266593-hmx2wy1p 33 20 so so IN cord-266593-hmx2wy1p 33 21 that that DT cord-266593-hmx2wy1p 33 22 day day NN cord-266593-hmx2wy1p 33 23 of of IN cord-266593-hmx2wy1p 33 24 symptom symptom NN cord-266593-hmx2wy1p 33 25 onset onset NN cord-266593-hmx2wy1p 33 26 for for IN cord-266593-hmx2wy1p 33 27 subsequent subsequent JJ cord-266593-hmx2wy1p 33 28 cases case NNS cord-266593-hmx2wy1p 33 29 within within IN cord-266593-hmx2wy1p 33 30 that that DT cord-266593-hmx2wy1p 33 31 household household NN cord-266593-hmx2wy1p 33 32 are be VBP cord-266593-hmx2wy1p 33 33 recorded record VBN cord-266593-hmx2wy1p 33 34 . . . cord-266593-hmx2wy1p 34 1 Studies study NNS cord-266593-hmx2wy1p 34 2 of of IN cord-266593-hmx2wy1p 34 3 this this DT cord-266593-hmx2wy1p 34 4 form form NN cord-266593-hmx2wy1p 34 5 were be VBD cord-266593-hmx2wy1p 34 6 developed develop VBN cord-266593-hmx2wy1p 34 7 for for IN cord-266593-hmx2wy1p 34 8 pandemic pandemic NN cord-266593-hmx2wy1p 34 9 influenza influenza NN cord-266593-hmx2wy1p 34 10 in in IN cord-266593-hmx2wy1p 34 11 2009 2009 CD cord-266593-hmx2wy1p 34 12 in in IN cord-266593-hmx2wy1p 34 13 both both CC cord-266593-hmx2wy1p 34 14 the the DT cord-266593-hmx2wy1p 34 15 United United NNP cord-266593-hmx2wy1p 34 16 Kingdom Kingdom NNP cord-266593-hmx2wy1p 34 17 ( ( -LRB- cord-266593-hmx2wy1p 34 18 McLean McLean NNP cord-266593-hmx2wy1p 34 19 et et NNP cord-266593-hmx2wy1p 34 20 al al NNP cord-266593-hmx2wy1p 34 21 . . NNP cord-266593-hmx2wy1p 34 22 , , , cord-266593-hmx2wy1p 34 23 2010 2010 CD cord-266593-hmx2wy1p 34 24 ) ) -RRB- cord-266593-hmx2wy1p 34 25 and and CC cord-266593-hmx2wy1p 34 26 the the DT cord-266593-hmx2wy1p 34 27 Netherlands Netherlands NNP cord-266593-hmx2wy1p 34 28 ( ( -LRB- cord-266593-hmx2wy1p 34 29 van van NNP cord-266593-hmx2wy1p 34 30 Gageldonk Gageldonk NNP cord-266593-hmx2wy1p 34 31 - - HYPH cord-266593-hmx2wy1p 34 32 Lafeber Lafeber NNP cord-266593-hmx2wy1p 34 33 et et NNP cord-266593-hmx2wy1p 34 34 al al NNP cord-266593-hmx2wy1p 34 35 . . NNP cord-266593-hmx2wy1p 34 36 , , , cord-266593-hmx2wy1p 34 37 2012 2012 CD cord-266593-hmx2wy1p 34 38 ) ) -RRB- cord-266593-hmx2wy1p 34 39 ; ; : cord-266593-hmx2wy1p 34 40 and and CC cord-266593-hmx2wy1p 34 41 have have VBP cord-266593-hmx2wy1p 34 42 been be VBN cord-266593-hmx2wy1p 34 43 instituted institute VBN cord-266593-hmx2wy1p 34 44 in in IN cord-266593-hmx2wy1p 34 45 response response NN cord-266593-hmx2wy1p 34 46 to to IN cord-266593-hmx2wy1p 34 47 a a DT cord-266593-hmx2wy1p 34 48 lack lack NN cord-266593-hmx2wy1p 34 49 of of IN cord-266593-hmx2wy1p 34 50 methods method NNS cord-266593-hmx2wy1p 34 51 for for IN cord-266593-hmx2wy1p 34 52 determining determine VBG cord-266593-hmx2wy1p 34 53 disease disease NN cord-266593-hmx2wy1p 34 54 epidemiology epidemiology NN cord-266593-hmx2wy1p 34 55 as as IN cord-266593-hmx2wy1p 34 56 required require VBN cord-266593-hmx2wy1p 34 57 for for IN cord-266593-hmx2wy1p 34 58 determining determine VBG cord-266593-hmx2wy1p 34 59 a a DT cord-266593-hmx2wy1p 34 60 proportionate proportionate JJ cord-266593-hmx2wy1p 34 61 response response NN cord-266593-hmx2wy1p 34 62 to to IN cord-266593-hmx2wy1p 34 63 novel novel JJ cord-266593-hmx2wy1p 34 64 outbreaks outbreak NNS cord-266593-hmx2wy1p 34 65 . . . cord-266593-hmx2wy1p 35 1 In in IN cord-266593-hmx2wy1p 35 2 the the DT cord-266593-hmx2wy1p 35 3 Australian Australian NNP cord-266593-hmx2wy1p 35 4 Health Health NNP cord-266593-hmx2wy1p 35 5 Management Management NNP cord-266593-hmx2wy1p 35 6 Plan Plan NNP cord-266593-hmx2wy1p 35 7 for for IN cord-266593-hmx2wy1p 35 8 Pandemic Pandemic NNP cord-266593-hmx2wy1p 35 9 Influenza Influenza NNP cord-266593-hmx2wy1p 35 10 ( ( -LRB- cord-266593-hmx2wy1p 35 11 AHMPPI AHMPPI NNP cord-266593-hmx2wy1p 35 12 ) ) -RRB- cord-266593-hmx2wy1p 35 13 , , , cord-266593-hmx2wy1p 35 14 First First NNP cord-266593-hmx2wy1p 35 15 Few few JJ cord-266593-hmx2wy1p 35 16 Hundred hundred CD cord-266593-hmx2wy1p 35 17 studies study NNS cord-266593-hmx2wy1p 35 18 are be VBP cord-266593-hmx2wy1p 35 19 proposed propose VBN cord-266593-hmx2wy1p 35 20 to to TO cord-266593-hmx2wy1p 35 21 be be VB cord-266593-hmx2wy1p 35 22 implemented implement VBN cord-266593-hmx2wy1p 35 23 following follow VBG cord-266593-hmx2wy1p 35 24 the the DT cord-266593-hmx2wy1p 35 25 first first JJ cord-266593-hmx2wy1p 35 26 case case NN cord-266593-hmx2wy1p 35 27 of of IN cord-266593-hmx2wy1p 35 28 a a DT cord-266593-hmx2wy1p 35 29 novel novel JJ cord-266593-hmx2wy1p 35 30 influenza influenza NN cord-266593-hmx2wy1p 35 31 strain strain NN cord-266593-hmx2wy1p 35 32 , , , cord-266593-hmx2wy1p 35 33 with with IN cord-266593-hmx2wy1p 35 34 households household NNS cord-266593-hmx2wy1p 35 35 being be VBG cord-266593-hmx2wy1p 35 36 tracked track VBN cord-266593-hmx2wy1p 35 37 nationally nationally RB cord-266593-hmx2wy1p 35 38 ( ( -LRB- cord-266593-hmx2wy1p 35 39 but but CC cord-266593-hmx2wy1p 35 40 managed manage VBN cord-266593-hmx2wy1p 35 41 at at IN cord-266593-hmx2wy1p 35 42 the the DT cord-266593-hmx2wy1p 35 43 state state NN cord-266593-hmx2wy1p 35 44 / / SYM cord-266593-hmx2wy1p 35 45 territory territory NN cord-266593-hmx2wy1p 35 46 level level NN cord-266593-hmx2wy1p 35 47 ) ) -RRB- cord-266593-hmx2wy1p 35 48 ( ( -LRB- cord-266593-hmx2wy1p 35 49 AHMPPI AHMPPI NNP cord-266593-hmx2wy1p 35 50 , , , cord-266593-hmx2wy1p 35 51 2014 2014 CD cord-266593-hmx2wy1p 35 52 ) ) -RRB- cord-266593-hmx2wy1p 35 53 . . . cord-266593-hmx2wy1p 36 1 Methods method NNS cord-266593-hmx2wy1p 36 2 have have VBP cord-266593-hmx2wy1p 36 3 recently recently RB cord-266593-hmx2wy1p 36 4 been be VBN cord-266593-hmx2wy1p 36 5 developed develop VBN cord-266593-hmx2wy1p 36 6 to to TO cord-266593-hmx2wy1p 36 7 characterise characterise VB cord-266593-hmx2wy1p 36 8 transmissibility transmissibility NN cord-266593-hmx2wy1p 36 9 and and CC cord-266593-hmx2wy1p 36 10 severity severity NN cord-266593-hmx2wy1p 36 11 of of IN cord-266593-hmx2wy1p 36 12 a a DT cord-266593-hmx2wy1p 36 13 novel novel JJ cord-266593-hmx2wy1p 36 14 pathogen pathogen NN cord-266593-hmx2wy1p 36 15 -other -other NN cord-266593-hmx2wy1p 36 16 factors factor NNS cord-266593-hmx2wy1p 36 17 influencing influence VBG cord-266593-hmx2wy1p 36 18 ability ability NN cord-266593-hmx2wy1p 36 19 to to TO cord-266593-hmx2wy1p 36 20 control control VB cord-266593-hmx2wy1p 36 21 an an DT cord-266593-hmx2wy1p 36 22 outbreak outbreak NN cord-266593-hmx2wy1p 36 23 -based -base VBN cord-266593-hmx2wy1p 36 24 on on IN cord-266593-hmx2wy1p 36 25 such such JJ cord-266593-hmx2wy1p 36 26 data datum NNS cord-266593-hmx2wy1p 36 27 Walker Walker NNP cord-266593-hmx2wy1p 36 28 et et NNP cord-266593-hmx2wy1p 36 29 al al NNP cord-266593-hmx2wy1p 36 30 . . NNP cord-266593-hmx2wy1p 36 31 , , , cord-266593-hmx2wy1p 36 32 2017 2017 CD cord-266593-hmx2wy1p 36 33 ) ) -RRB- cord-266593-hmx2wy1p 36 34 . . . cord-266593-hmx2wy1p 37 1 Currently currently RB cord-266593-hmx2wy1p 37 2 lacking lack VBG cord-266593-hmx2wy1p 37 3 is be VBZ cord-266593-hmx2wy1p 37 4 a a DT cord-266593-hmx2wy1p 37 5 method method NN cord-266593-hmx2wy1p 37 6 for for IN cord-266593-hmx2wy1p 37 7 accuhttps://doi.org/10.1016/j.jtbi.2019.110079 accuhttps://doi.org/10.1016/j.jtbi.2019.110079 CD cord-266593-hmx2wy1p 37 8 0022 0022 CD cord-266593-hmx2wy1p 37 9 - - . cord-266593-hmx2wy1p 37 10 5193/ 5193/ CD cord-266593-hmx2wy1p 38 1 © © NNP cord-266593-hmx2wy1p 38 2 2019 2019 CD cord-266593-hmx2wy1p 38 3 Elsevier Elsevier NNP cord-266593-hmx2wy1p 38 4 Ltd. Ltd. NNP cord-266593-hmx2wy1p 39 1 All all DT cord-266593-hmx2wy1p 39 2 rights right NNS cord-266593-hmx2wy1p 39 3 reserved reserve VBN cord-266593-hmx2wy1p 39 4 . . . cord-266593-hmx2wy1p 40 1 between between IN cord-266593-hmx2wy1p 40 2 states state NNS cord-266593-hmx2wy1p 40 3 within within IN cord-266593-hmx2wy1p 40 4 each each DT cord-266593-hmx2wy1p 40 5 household household NN cord-266593-hmx2wy1p 40 6 continuous continuous JJ cord-266593-hmx2wy1p 40 7 - - HYPH cord-266593-hmx2wy1p 40 8 time time NN cord-266593-hmx2wy1p 40 9 Markov Markov NNP cord-266593-hmx2wy1p 40 10 chain chain NN cord-266593-hmx2wy1p 40 11 ; ; : cord-266593-hmx2wy1p 40 12 the the DT cord-266593-hmx2wy1p 40 13 five five CD cord-266593-hmx2wy1p 40 14 observation observation NN cord-266593-hmx2wy1p 40 15 models model NNS cord-266593-hmx2wy1p 40 16 being be VBG cord-266593-hmx2wy1p 40 17 discriminated discriminate VBN cord-266593-hmx2wy1p 40 18 between between IN cord-266593-hmx2wy1p 40 19 ; ; : cord-266593-hmx2wy1p 40 20 and and CC cord-266593-hmx2wy1p 40 21 , , , cord-266593-hmx2wy1p 40 22 the the DT cord-266593-hmx2wy1p 40 23 way way NN cord-266593-hmx2wy1p 40 24 that that WDT cord-266593-hmx2wy1p 40 25 these these DT cord-266593-hmx2wy1p 40 26 household household NN cord-266593-hmx2wy1p 40 27 - - HYPH cord-266593-hmx2wy1p 40 28 level level NN cord-266593-hmx2wy1p 40 29 data datum NNS cord-266593-hmx2wy1p 40 30 are be VBP cord-266593-hmx2wy1p 40 31 observed observe VBN cord-266593-hmx2wy1p 40 32 . . . cord-266593-hmx2wy1p 41 1 The the DT cord-266593-hmx2wy1p 41 2 data datum NNS cord-266593-hmx2wy1p 41 3 observed observe VBD cord-266593-hmx2wy1p 41 4 in in IN cord-266593-hmx2wy1p 41 5 each each DT cord-266593-hmx2wy1p 41 6 model model NN cord-266593-hmx2wy1p 41 7 are be VBP cord-266593-hmx2wy1p 41 8 the the DT cord-266593-hmx2wy1p 41 9 number number NN cord-266593-hmx2wy1p 41 10 of of IN cord-266593-hmx2wy1p 41 11 observations observation NNS cord-266593-hmx2wy1p 41 12 of of IN cord-266593-hmx2wy1p 41 13 the the DT cord-266593-hmx2wy1p 41 14 relevant relevant JJ cord-266593-hmx2wy1p 41 15 transition transition NN cord-266593-hmx2wy1p 41 16 each each DT cord-266593-hmx2wy1p 41 17 day day NN cord-266593-hmx2wy1p 41 18 , , , cord-266593-hmx2wy1p 41 19 within within IN cord-266593-hmx2wy1p 41 20 each each DT cord-266593-hmx2wy1p 41 21 household household NN cord-266593-hmx2wy1p 41 22 : : : cord-266593-hmx2wy1p 41 23 data datum NNS cord-266593-hmx2wy1p 41 24 from from IN cord-266593-hmx2wy1p 41 25 four four CD cord-266593-hmx2wy1p 41 26 illustrative illustrative JJ cord-266593-hmx2wy1p 41 27 sample sample NN cord-266593-hmx2wy1p 41 28 households household NNS cord-266593-hmx2wy1p 41 29 are be VBP cord-266593-hmx2wy1p 41 30 shown show VBN cord-266593-hmx2wy1p 41 31 here here RB cord-266593-hmx2wy1p 41 32 . . . cord-266593-hmx2wy1p 42 1 ( ( -LRB- cord-266593-hmx2wy1p 42 2 b b LS cord-266593-hmx2wy1p 42 3 ) ) -RRB- cord-266593-hmx2wy1p 42 4 Random random JJ cord-266593-hmx2wy1p 42 5 forest forest NN cord-266593-hmx2wy1p 42 6 feature feature VBP cord-266593-hmx2wy1p 42 7 importance importance NN cord-266593-hmx2wy1p 42 8 for for IN cord-266593-hmx2wy1p 42 9 the the DT cord-266593-hmx2wy1p 42 10 full full JJ cord-266593-hmx2wy1p 42 11 14day 14day NNP cord-266593-hmx2wy1p 42 12 design design NN cord-266593-hmx2wy1p 42 13 , , , cord-266593-hmx2wy1p 42 14 used use VBD cord-266593-hmx2wy1p 42 15 to to TO cord-266593-hmx2wy1p 42 16 construct construct VB cord-266593-hmx2wy1p 42 17 the the DT cord-266593-hmx2wy1p 42 18 heuristic heuristic NN cord-266593-hmx2wy1p 42 19 for for IN cord-266593-hmx2wy1p 42 20 smaller small JJR cord-266593-hmx2wy1p 42 21 designs design NNS cord-266593-hmx2wy1p 42 22 . . . cord-266593-hmx2wy1p 43 1 Each each DT cord-266593-hmx2wy1p 43 2 bar bar NN cord-266593-hmx2wy1p 43 3 represents represent VBZ cord-266593-hmx2wy1p 43 4 a a DT cord-266593-hmx2wy1p 43 5 feature feature NN cord-266593-hmx2wy1p 43 6 , , , cord-266593-hmx2wy1p 43 7 so so RB cord-266593-hmx2wy1p 43 8 within within IN cord-266593-hmx2wy1p 43 9 each each DT cord-266593-hmx2wy1p 43 10 day day NN cord-266593-hmx2wy1p 43 11 there there EX cord-266593-hmx2wy1p 43 12 are be VBP cord-266593-hmx2wy1p 43 13 ( ( -LRB- cord-266593-hmx2wy1p 43 14 in in IN cord-266593-hmx2wy1p 43 15 this this DT cord-266593-hmx2wy1p 43 16 case case NN cord-266593-hmx2wy1p 43 17 , , , cord-266593-hmx2wy1p 43 18 for for IN cord-266593-hmx2wy1p 43 19 households household NNS cord-266593-hmx2wy1p 43 20 of of IN cord-266593-hmx2wy1p 43 21 size size NN cord-266593-hmx2wy1p 43 22 5 5 CD cord-266593-hmx2wy1p 43 23 ) ) -RRB- cord-266593-hmx2wy1p 43 24 6 6 CD cord-266593-hmx2wy1p 43 25 features feature NNS cord-266593-hmx2wy1p 43 26 , , , cord-266593-hmx2wy1p 43 27 corresponding correspond VBG cord-266593-hmx2wy1p 43 28 to to IN cord-266593-hmx2wy1p 43 29 the the DT cord-266593-hmx2wy1p 43 30 proportion proportion NN cord-266593-hmx2wy1p 43 31 of of IN cord-266593-hmx2wy1p 43 32 households household NNS cord-266593-hmx2wy1p 43 33 with with IN cord-266593-hmx2wy1p 43 34 each each DT cord-266593-hmx2wy1p 43 35 incidence incidence NN cord-266593-hmx2wy1p 43 36 count count NN cord-266593-hmx2wy1p 43 37 , , , cord-266593-hmx2wy1p 43 38 each each DT cord-266593-hmx2wy1p 43 39 day day NN cord-266593-hmx2wy1p 43 40 . . . cord-266593-hmx2wy1p 44 1 ( ( -LRB- cord-266593-hmx2wy1p 44 2 c c NN cord-266593-hmx2wy1p 44 3 ) ) -RRB- cord-266593-hmx2wy1p 44 4 Resulting result VBG cord-266593-hmx2wy1p 44 5 random random JJ cord-266593-hmx2wy1p 44 6 forest forest NN cord-266593-hmx2wy1p 44 7 accuracy accuracy NN cord-266593-hmx2wy1p 44 8 ( ( -LRB- cord-266593-hmx2wy1p 44 9 proportion proportion NN cord-266593-hmx2wy1p 44 10 of of IN cord-266593-hmx2wy1p 44 11 test test NN cord-266593-hmx2wy1p 44 12 simulations simulation NNS cord-266593-hmx2wy1p 44 13 assigned assign VBN cord-266593-hmx2wy1p 44 14 to to IN cord-266593-hmx2wy1p 44 15 the the DT cord-266593-hmx2wy1p 44 16 correct correct JJ cord-266593-hmx2wy1p 44 17 model model NN cord-266593-hmx2wy1p 44 18 ) ) -RRB- cord-266593-hmx2wy1p 44 19 as as IN cord-266593-hmx2wy1p 44 20 design design NN cord-266593-hmx2wy1p 44 21 size size NN cord-266593-hmx2wy1p 44 22 increases increase NNS cord-266593-hmx2wy1p 44 23 , , , cord-266593-hmx2wy1p 44 24 for for IN cord-266593-hmx2wy1p 44 25 the the DT cord-266593-hmx2wy1p 44 26 true true JJ cord-266593-hmx2wy1p 44 27 optimal optimal JJ cord-266593-hmx2wy1p 44 28 design design NN cord-266593-hmx2wy1p 44 29 ( ( -LRB- cord-266593-hmx2wy1p 44 30 solid solid JJ cord-266593-hmx2wy1p 44 31 lines line NNS cord-266593-hmx2wy1p 44 32 ) ) -RRB- cord-266593-hmx2wy1p 44 33 and and CC cord-266593-hmx2wy1p 44 34 heuristic heuristic JJ cord-266593-hmx2wy1p 44 35 solution solution NN cord-266593-hmx2wy1p 44 36 ( ( -LRB- cord-266593-hmx2wy1p 44 37 crosses crosse NNS cord-266593-hmx2wy1p 44 38 with with IN cord-266593-hmx2wy1p 44 39 dashed dash VBN cord-266593-hmx2wy1p 44 40 line line NN cord-266593-hmx2wy1p 44 41 ) ) -RRB- cord-266593-hmx2wy1p 44 42 . . . cord-266593-hmx2wy1p 45 1 In in IN cord-266593-hmx2wy1p 45 2 this this DT cord-266593-hmx2wy1p 45 3 case case NN cord-266593-hmx2wy1p 45 4 , , , cord-266593-hmx2wy1p 45 5 random random JJ cord-266593-hmx2wy1p 45 6 assignment assignment NN cord-266593-hmx2wy1p 45 7 would would MD cord-266593-hmx2wy1p 45 8 produce produce VB cord-266593-hmx2wy1p 45 9 accuracy accuracy NN cord-266593-hmx2wy1p 45 10 0.2 0.2 CD cord-266593-hmx2wy1p 45 11 . . . cord-266593-hmx2wy1p 46 1 ( ( -LRB- cord-266593-hmx2wy1p 46 2 d d LS cord-266593-hmx2wy1p 46 3 ) ) -RRB- cord-266593-hmx2wy1p 46 4 Two two CD cord-266593-hmx2wy1p 46 5 - - HYPH cord-266593-hmx2wy1p 46 6 class class NN cord-266593-hmx2wy1p 46 7 accuracy accuracy NN cord-266593-hmx2wy1p 46 8 of of IN cord-266593-hmx2wy1p 46 9 random random JJ cord-266593-hmx2wy1p 46 10 forest forest NN cord-266593-hmx2wy1p 46 11 model model NN cord-266593-hmx2wy1p 46 12 discrimination discrimination NN cord-266593-hmx2wy1p 46 13 : : : cord-266593-hmx2wy1p 47 1 this this DT cord-266593-hmx2wy1p 47 2 measures measure VBZ cord-266593-hmx2wy1p 47 3 the the DT cord-266593-hmx2wy1p 47 4 accuracy accuracy NN cord-266593-hmx2wy1p 47 5 of of IN cord-266593-hmx2wy1p 47 6 discrimination discrimination NN cord-266593-hmx2wy1p 47 7 between between IN cord-266593-hmx2wy1p 47 8 models model NNS cord-266593-hmx2wy1p 47 9 with with IN cord-266593-hmx2wy1p 47 10 symptoms symptom NNS cord-266593-hmx2wy1p 47 11 before before IN cord-266593-hmx2wy1p 47 12 or or CC cord-266593-hmx2wy1p 47 13 coincident coincident JJ cord-266593-hmx2wy1p 47 14 with with IN cord-266593-hmx2wy1p 47 15 infectiousness infectiousness NN cord-266593-hmx2wy1p 47 16 , , , cord-266593-hmx2wy1p 47 17 versus versus IN cord-266593-hmx2wy1p 47 18 models model NNS cord-266593-hmx2wy1p 47 19 with with IN cord-266593-hmx2wy1p 47 20 symptoms symptom NNS cord-266593-hmx2wy1p 47 21 beginning begin VBG cord-266593-hmx2wy1p 47 22 after after IN cord-266593-hmx2wy1p 47 23 infectiousness infectiousness NN cord-266593-hmx2wy1p 47 24 . . . cord-266593-hmx2wy1p 48 1 In in IN cord-266593-hmx2wy1p 48 2 this this DT cord-266593-hmx2wy1p 48 3 case case NN cord-266593-hmx2wy1p 48 4 , , , cord-266593-hmx2wy1p 48 5 random random JJ cord-266593-hmx2wy1p 48 6 assignment assignment NN cord-266593-hmx2wy1p 48 7 would would MD cord-266593-hmx2wy1p 48 8 produce produce VB cord-266593-hmx2wy1p 48 9 accuracy accuracy NN cord-266593-hmx2wy1p 48 10 0.52 0.52 CD cord-266593-hmx2wy1p 48 11 ( ( -LRB- cord-266593-hmx2wy1p 48 12 red red NNP cord-266593-hmx2wy1p 48 13 dashed dash VBD cord-266593-hmx2wy1p 48 14 line line NN cord-266593-hmx2wy1p 48 15 ) ) -RRB- cord-266593-hmx2wy1p 48 16 . . . cord-266593-hmx2wy1p 49 1 These these DT cord-266593-hmx2wy1p 49 2 results result NNS cord-266593-hmx2wy1p 49 3 correspond correspond VBP cord-266593-hmx2wy1p 49 4 to to IN cord-266593-hmx2wy1p 49 5 households household NNS cord-266593-hmx2wy1p 49 6 of of IN cord-266593-hmx2wy1p 49 7 size size NN cord-266593-hmx2wy1p 49 8 5 5 CD cord-266593-hmx2wy1p 49 9 , , , cord-266593-hmx2wy1p 49 10 with with IN cord-266593-hmx2wy1p 49 11 10,0 10,0 CD cord-266593-hmx2wy1p 49 12 0 0 CD cord-266593-hmx2wy1p 49 13 0 0 CD cord-266593-hmx2wy1p 49 14 training training NN cord-266593-hmx2wy1p 49 15 samples sample NNS cord-266593-hmx2wy1p 49 16 from from IN cord-266593-hmx2wy1p 49 17 each each DT cord-266593-hmx2wy1p 49 18 model model NN cord-266593-hmx2wy1p 49 19 , , , cord-266593-hmx2wy1p 49 20 each each DT cord-266593-hmx2wy1p 49 21 with with IN cord-266593-hmx2wy1p 49 22 parameters parameter NNS cord-266593-hmx2wy1p 49 23 drawn draw VBN cord-266593-hmx2wy1p 49 24 from from IN cord-266593-hmx2wy1p 49 25 the the DT cord-266593-hmx2wy1p 49 26 distributions distribution NNS cord-266593-hmx2wy1p 49 27 displayed display VBN cord-266593-hmx2wy1p 49 28 in in IN cord-266593-hmx2wy1p 49 29 Supplemental supplemental JJ cord-266593-hmx2wy1p 49 30 Figure Figure NNP cord-266593-hmx2wy1p 49 31 S1 s1 NN cord-266593-hmx2wy1p 49 32 . . . cord-266593-hmx2wy1p 50 1 ( ( -LRB- cord-266593-hmx2wy1p 50 2 For for IN cord-266593-hmx2wy1p 50 3 interpretation interpretation NN cord-266593-hmx2wy1p 50 4 of of IN cord-266593-hmx2wy1p 50 5 the the DT cord-266593-hmx2wy1p 50 6 references reference NNS cord-266593-hmx2wy1p 50 7 to to TO cord-266593-hmx2wy1p 50 8 colour colour VB cord-266593-hmx2wy1p 50 9 in in IN cord-266593-hmx2wy1p 50 10 this this DT cord-266593-hmx2wy1p 50 11 figure figure NN cord-266593-hmx2wy1p 50 12 legend legend NN cord-266593-hmx2wy1p 50 13 , , , cord-266593-hmx2wy1p 50 14 the the DT cord-266593-hmx2wy1p 50 15 reader reader NN cord-266593-hmx2wy1p 50 16 is be VBZ cord-266593-hmx2wy1p 50 17 referred refer VBN cord-266593-hmx2wy1p 50 18 to to IN cord-266593-hmx2wy1p 50 19 the the DT cord-266593-hmx2wy1p 50 20 web web NN cord-266593-hmx2wy1p 50 21 version version NN cord-266593-hmx2wy1p 50 22 of of IN cord-266593-hmx2wy1p 50 23 this this DT cord-266593-hmx2wy1p 50 24 article article NN cord-266593-hmx2wy1p 50 25 . . . cord-266593-hmx2wy1p 50 26 ) ) -RRB- cord-266593-hmx2wy1p 51 1 rate rate NN cord-266593-hmx2wy1p 51 2 determination determination NN cord-266593-hmx2wy1p 51 3 of of IN cord-266593-hmx2wy1p 51 4 relative relative JJ cord-266593-hmx2wy1p 51 5 timing timing NN cord-266593-hmx2wy1p 51 6 of of IN cord-266593-hmx2wy1p 51 7 infectiousness infectiousness NN cord-266593-hmx2wy1p 51 8 and and CC cord-266593-hmx2wy1p 51 9 symptom symptom NN cord-266593-hmx2wy1p 51 10 onset onset NN cord-266593-hmx2wy1p 51 11 using use VBG cord-266593-hmx2wy1p 51 12 this this DT cord-266593-hmx2wy1p 51 13 data datum NNS cord-266593-hmx2wy1p 51 14 . . . cord-266593-hmx2wy1p 52 1 Here here RB cord-266593-hmx2wy1p 52 2 we -PRON- PRP cord-266593-hmx2wy1p 52 3 introduce introduce VBP cord-266593-hmx2wy1p 52 4 , , , cord-266593-hmx2wy1p 52 5 and and CC cord-266593-hmx2wy1p 52 6 demonstrate demonstrate VB cord-266593-hmx2wy1p 52 7 through through IN cord-266593-hmx2wy1p 52 8 a a DT cord-266593-hmx2wy1p 52 9 simulation simulation NN cord-266593-hmx2wy1p 52 10 study study NN cord-266593-hmx2wy1p 52 11 , , , cord-266593-hmx2wy1p 52 12 a a DT cord-266593-hmx2wy1p 52 13 method method NN cord-266593-hmx2wy1p 52 14 for for IN cord-266593-hmx2wy1p 52 15 identifying identify VBG cord-266593-hmx2wy1p 52 16 with with IN cord-266593-hmx2wy1p 52 17 high high JJ cord-266593-hmx2wy1p 52 18 accuracy accuracy NN cord-266593-hmx2wy1p 52 19 the the DT cord-266593-hmx2wy1p 52 20 timing timing NN cord-266593-hmx2wy1p 52 21 of of IN cord-266593-hmx2wy1p 52 22 infectiousness infectiousness NN cord-266593-hmx2wy1p 52 23 relative relative JJ cord-266593-hmx2wy1p 52 24 to to IN cord-266593-hmx2wy1p 52 25 symptom symptom NN cord-266593-hmx2wy1p 52 26 onset onset NN cord-266593-hmx2wy1p 52 27 from from IN cord-266593-hmx2wy1p 52 28 household household NN cord-266593-hmx2wy1p 52 29 - - HYPH cord-266593-hmx2wy1p 52 30 stratified stratify VBN cord-266593-hmx2wy1p 52 31 symptom symptom NN cord-266593-hmx2wy1p 52 32 surveillance surveillance NN cord-266593-hmx2wy1p 52 33 data datum NNS cord-266593-hmx2wy1p 52 34 ( ( -LRB- cord-266593-hmx2wy1p 52 35 generated generate VBN cord-266593-hmx2wy1p 52 36 via via IN cord-266593-hmx2wy1p 52 37 simulation simulation NN cord-266593-hmx2wy1p 52 38 ) ) -RRB- cord-266593-hmx2wy1p 52 39 . . . cord-266593-hmx2wy1p 53 1 Remarkably remarkably RB cord-266593-hmx2wy1p 53 2 , , , cord-266593-hmx2wy1p 53 3 we -PRON- PRP cord-266593-hmx2wy1p 53 4 show show VBP cord-266593-hmx2wy1p 53 5 this this DT cord-266593-hmx2wy1p 53 6 is be VBZ cord-266593-hmx2wy1p 53 7 achievable achievable JJ cord-266593-hmx2wy1p 53 8 with with IN cord-266593-hmx2wy1p 53 9 observations observation NNS cord-266593-hmx2wy1p 53 10 taken take VBN cord-266593-hmx2wy1p 53 11 on on RP cord-266593-hmx2wy1p 53 12 only only RB cord-266593-hmx2wy1p 53 13 a a DT cord-266593-hmx2wy1p 53 14 few few JJ cord-266593-hmx2wy1p 53 15 specific specific JJ cord-266593-hmx2wy1p 53 16 days day NNS cord-266593-hmx2wy1p 53 17 , , , cord-266593-hmx2wy1p 53 18 chosen choose VBN cord-266593-hmx2wy1p 53 19 optimally optimally RB cord-266593-hmx2wy1p 53 20 , , , cord-266593-hmx2wy1p 53 21 within within IN cord-266593-hmx2wy1p 53 22 each each DT cord-266593-hmx2wy1p 53 23 household household NN cord-266593-hmx2wy1p 53 24 . . . cord-266593-hmx2wy1p 54 1 Our -PRON- PRP$ cord-266593-hmx2wy1p 54 2 approach approach NN cord-266593-hmx2wy1p 54 3 to to IN cord-266593-hmx2wy1p 54 4 determining determine VBG cord-266593-hmx2wy1p 54 5 the the DT cord-266593-hmx2wy1p 54 6 optimal optimal JJ cord-266593-hmx2wy1p 54 7 surveillance surveillance NN cord-266593-hmx2wy1p 54 8 scheme scheme NN cord-266593-hmx2wy1p 54 9 is be VBZ cord-266593-hmx2wy1p 54 10 based base VBN cord-266593-hmx2wy1p 54 11 on on IN cord-266593-hmx2wy1p 54 12 an an DT cord-266593-hmx2wy1p 54 13 efficient efficient JJ cord-266593-hmx2wy1p 54 14 heuristic heuristic NN cord-266593-hmx2wy1p 54 15 . . . cord-266593-hmx2wy1p 55 1 This this DT cord-266593-hmx2wy1p 55 2 heuristic heuristic NN cord-266593-hmx2wy1p 55 3 provides provide VBZ cord-266593-hmx2wy1p 55 4 a a DT cord-266593-hmx2wy1p 55 5 general general JJ cord-266593-hmx2wy1p 55 6 , , , cord-266593-hmx2wy1p 55 7 computationally computationally RB cord-266593-hmx2wy1p 55 8 - - HYPH cord-266593-hmx2wy1p 55 9 efficient efficient JJ cord-266593-hmx2wy1p 55 10 approach approach NN cord-266593-hmx2wy1p 55 11 to to IN cord-266593-hmx2wy1p 55 12 optimal optimal JJ cord-266593-hmx2wy1p 55 13 design design NN cord-266593-hmx2wy1p 55 14 for for IN cord-266593-hmx2wy1p 55 15 Bayesian bayesian JJ cord-266593-hmx2wy1p 55 16 model model NN cord-266593-hmx2wy1p 55 17 discrimination discrimination NN cord-266593-hmx2wy1p 55 18 . . . cord-266593-hmx2wy1p 56 1 We -PRON- PRP cord-266593-hmx2wy1p 56 2 model model VBP cord-266593-hmx2wy1p 56 3 disease disease NN cord-266593-hmx2wy1p 56 4 dynamics dynamic NNS cord-266593-hmx2wy1p 56 5 within within IN cord-266593-hmx2wy1p 56 6 each each DT cord-266593-hmx2wy1p 56 7 household household NN cord-266593-hmx2wy1p 56 8 as as IN cord-266593-hmx2wy1p 56 9 a a DT cord-266593-hmx2wy1p 56 10 continuous continuous JJ cord-266593-hmx2wy1p 56 11 - - HYPH cord-266593-hmx2wy1p 56 12 time time NN cord-266593-hmx2wy1p 56 13 Markov Markov NNP cord-266593-hmx2wy1p 56 14 chain chain NN cord-266593-hmx2wy1p 56 15 ( ( -LRB- cord-266593-hmx2wy1p 56 16 Keeling Keeling NNP cord-266593-hmx2wy1p 56 17 and and CC cord-266593-hmx2wy1p 56 18 Ross Ross NNP cord-266593-hmx2wy1p 56 19 , , , cord-266593-hmx2wy1p 56 20 2008 2008 CD cord-266593-hmx2wy1p 56 21 ) ) -RRB- cord-266593-hmx2wy1p 56 22 , , , cord-266593-hmx2wy1p 56 23 that that WDT cord-266593-hmx2wy1p 56 24 counts count VBZ cord-266593-hmx2wy1p 56 25 the the DT cord-266593-hmx2wy1p 56 26 number number NN cord-266593-hmx2wy1p 56 27 of of IN cord-266593-hmx2wy1p 56 28 household household NN cord-266593-hmx2wy1p 56 29 members member NNS cord-266593-hmx2wy1p 56 30 that that WDT cord-266593-hmx2wy1p 56 31 are be VBP cord-266593-hmx2wy1p 56 32 susceptible susceptible JJ cord-266593-hmx2wy1p 56 33 ( ( -LRB- cord-266593-hmx2wy1p 56 34 S S NNP cord-266593-hmx2wy1p 56 35 ) ) -RRB- cord-266593-hmx2wy1p 56 36 , , , cord-266593-hmx2wy1p 56 37 exposed expose VBN cord-266593-hmx2wy1p 56 38 ( ( -LRB- cord-266593-hmx2wy1p 56 39 E e NN cord-266593-hmx2wy1p 56 40 1 1 CD cord-266593-hmx2wy1p 56 41 and and CC cord-266593-hmx2wy1p 56 42 E E NNP cord-266593-hmx2wy1p 56 43 2 2 CD cord-266593-hmx2wy1p 56 44 ) ) -RRB- cord-266593-hmx2wy1p 56 45 , , . cord-266593-hmx2wy1p 57 1 infectious infectious JJ cord-266593-hmx2wy1p 57 2 ( ( -LRB- cord-266593-hmx2wy1p 58 1 I -PRON- PRP cord-266593-hmx2wy1p 58 2 1 1 CD cord-266593-hmx2wy1p 58 3 and and CC cord-266593-hmx2wy1p 58 4 I -PRON- PRP cord-266593-hmx2wy1p 58 5 2 2 CD cord-266593-hmx2wy1p 58 6 ) ) -RRB- cord-266593-hmx2wy1p 58 7 , , , cord-266593-hmx2wy1p 58 8 or or CC cord-266593-hmx2wy1p 58 9 recovered recover VBN cord-266593-hmx2wy1p 58 10 ( ( -LRB- cord-266593-hmx2wy1p 58 11 and and CC cord-266593-hmx2wy1p 58 12 immune immune JJ cord-266593-hmx2wy1p 58 13 ; ; : cord-266593-hmx2wy1p 58 14 R r NN cord-266593-hmx2wy1p 58 15 ) ) -RRB- cord-266593-hmx2wy1p 58 16 . . . cord-266593-hmx2wy1p 59 1 Two two CD cord-266593-hmx2wy1p 59 2 compartments compartment NNS cord-266593-hmx2wy1p 59 3 for for IN cord-266593-hmx2wy1p 59 4 exposed exposed JJ cord-266593-hmx2wy1p 59 5 and and CC cord-266593-hmx2wy1p 59 6 infectious infectious JJ cord-266593-hmx2wy1p 59 7 individuals individual NNS cord-266593-hmx2wy1p 59 8 allows allow VBZ cord-266593-hmx2wy1p 59 9 for for IN cord-266593-hmx2wy1p 59 10 a a DT cord-266593-hmx2wy1p 59 11 broad broad JJ cord-266593-hmx2wy1p 59 12 range range NN cord-266593-hmx2wy1p 59 13 outbreak outbreak NN cord-266593-hmx2wy1p 59 14 observation observation NN cord-266593-hmx2wy1p 59 15 dynamics dynamic NNS cord-266593-hmx2wy1p 59 16 , , , cord-266593-hmx2wy1p 59 17 and and CC cord-266593-hmx2wy1p 59 18 allows allow VBZ cord-266593-hmx2wy1p 59 19 Erlang Erlang NNP cord-266593-hmx2wy1p 59 20 - - HYPH cord-266593-hmx2wy1p 59 21 distributed distribute VBN cord-266593-hmx2wy1p 59 22 exposed expose VBN cord-266593-hmx2wy1p 59 23 and and CC cord-266593-hmx2wy1p 59 24 infectious infectious JJ cord-266593-hmx2wy1p 59 25 periods period NNS cord-266593-hmx2wy1p 59 26 . . . cord-266593-hmx2wy1p 60 1 Under under IN cord-266593-hmx2wy1p 60 2 this this DT cord-266593-hmx2wy1p 60 3 model model NN cord-266593-hmx2wy1p 60 4 , , , cord-266593-hmx2wy1p 60 5 the the DT cord-266593-hmx2wy1p 60 6 timing timing NN cord-266593-hmx2wy1p 60 7 of of IN cord-266593-hmx2wy1p 60 8 symptom symptom NN cord-266593-hmx2wy1p 60 9 onset onset NN cord-266593-hmx2wy1p 60 10 relative relative NN cord-266593-hmx2wy1p 60 11 to to IN cord-266593-hmx2wy1p 60 12 infectiousness infectiousness NN cord-266593-hmx2wy1p 60 13 is be VBZ cord-266593-hmx2wy1p 60 14 mapped map VBN cord-266593-hmx2wy1p 60 15 to to IN cord-266593-hmx2wy1p 60 16 which which WDT cord-266593-hmx2wy1p 60 17 transition transition NN cord-266593-hmx2wy1p 60 18 is be VBZ cord-266593-hmx2wy1p 60 19 observed observe VBN cord-266593-hmx2wy1p 60 20 : : : cord-266593-hmx2wy1p 60 21 symptoms symptom NNS cord-266593-hmx2wy1p 60 22 appear appear VBP cord-266593-hmx2wy1p 60 23 either either CC cord-266593-hmx2wy1p 60 24 upon upon IN cord-266593-hmx2wy1p 60 25 infection infection NN cord-266593-hmx2wy1p 60 26 , , , cord-266593-hmx2wy1p 60 27 between between IN cord-266593-hmx2wy1p 60 28 infection infection NN cord-266593-hmx2wy1p 60 29 and and CC cord-266593-hmx2wy1p 60 30 infectiousness infectiousness NN cord-266593-hmx2wy1p 60 31 , , , cord-266593-hmx2wy1p 60 32 coincident coincident JJ cord-266593-hmx2wy1p 60 33 with with IN cord-266593-hmx2wy1p 60 34 infectiousness infectiousness NN cord-266593-hmx2wy1p 60 35 , , , cord-266593-hmx2wy1p 60 36 between between IN cord-266593-hmx2wy1p 60 37 infectiousness infectiousness NN cord-266593-hmx2wy1p 60 38 and and CC cord-266593-hmx2wy1p 60 39 recovery recovery NN cord-266593-hmx2wy1p 60 40 , , , cord-266593-hmx2wy1p 60 41 or or CC cord-266593-hmx2wy1p 60 42 upon upon IN cord-266593-hmx2wy1p 60 43 recovery recovery NN cord-266593-hmx2wy1p 60 44 . . . cord-266593-hmx2wy1p 61 1 The the DT cord-266593-hmx2wy1p 61 2 challenge challenge NN cord-266593-hmx2wy1p 61 3 is be VBZ cord-266593-hmx2wy1p 61 4 to to TO cord-266593-hmx2wy1p 61 5 determine determine VB cord-266593-hmx2wy1p 61 6 which which WDT cord-266593-hmx2wy1p 61 7 of of IN cord-266593-hmx2wy1p 61 8 these these DT cord-266593-hmx2wy1p 61 9 five five CD cord-266593-hmx2wy1p 61 10 ( ( -LRB- cord-266593-hmx2wy1p 61 11 observation observation NN cord-266593-hmx2wy1p 61 12 ) ) -RRB- cord-266593-hmx2wy1p 61 13 models model NNS cord-266593-hmx2wy1p 61 14 best well RBS cord-266593-hmx2wy1p 61 15 describes describe VBZ cord-266593-hmx2wy1p 61 16 the the DT cord-266593-hmx2wy1p 61 17 household household NN cord-266593-hmx2wy1p 61 18 - - HYPH cord-266593-hmx2wy1p 61 19 stratified stratify VBN cord-266593-hmx2wy1p 61 20 symptom symptom NN cord-266593-hmx2wy1p 61 21 - - HYPH cord-266593-hmx2wy1p 61 22 onset onset NN cord-266593-hmx2wy1p 61 23 data datum NNS cord-266593-hmx2wy1p 61 24 ( ( -LRB- cord-266593-hmx2wy1p 61 25 Fig Fig NNP cord-266593-hmx2wy1p 61 26 . . . cord-266593-hmx2wy1p 61 27 1 1 CD cord-266593-hmx2wy1p 61 28 a a LS cord-266593-hmx2wy1p 61 29 ) ) -RRB- cord-266593-hmx2wy1p 61 30 . . . cord-266593-hmx2wy1p 62 1 There there EX cord-266593-hmx2wy1p 62 2 is be VBZ cord-266593-hmx2wy1p 62 3 a a DT cord-266593-hmx2wy1p 62 4 relatively relatively RB cord-266593-hmx2wy1p 62 5 rich rich JJ cord-266593-hmx2wy1p 62 6 literature literature NN cord-266593-hmx2wy1p 62 7 on on IN cord-266593-hmx2wy1p 62 8 Bayesian bayesian JJ cord-266593-hmx2wy1p 62 9 model model NN cord-266593-hmx2wy1p 62 10 discrimination discrimination NN cord-266593-hmx2wy1p 62 11 ( ( -LRB- cord-266593-hmx2wy1p 62 12 Chopin Chopin NNP cord-266593-hmx2wy1p 62 13 et et NNP cord-266593-hmx2wy1p 62 14 al al NNP cord-266593-hmx2wy1p 62 15 . . NNP cord-266593-hmx2wy1p 62 16 , , , cord-266593-hmx2wy1p 62 17 2013 2013 CD cord-266593-hmx2wy1p 62 18 ; ; : cord-266593-hmx2wy1p 63 1 Drovandi Drovandi NNP cord-266593-hmx2wy1p 63 2 and and CC cord-266593-hmx2wy1p 63 3 Cutchan Cutchan NNP cord-266593-hmx2wy1p 63 4 , , , cord-266593-hmx2wy1p 63 5 2016 2016 CD cord-266593-hmx2wy1p 63 6 ; ; : cord-266593-hmx2wy1p 63 7 Alzahrani Alzahrani NNP cord-266593-hmx2wy1p 63 8 et et NNP cord-266593-hmx2wy1p 63 9 al al NNP cord-266593-hmx2wy1p 63 10 . . NNP cord-266593-hmx2wy1p 63 11 , , , cord-266593-hmx2wy1p 63 12 2018 2018 CD cord-266593-hmx2wy1p 63 13 ; ; : cord-266593-hmx2wy1p 63 14 Touloupou Touloupou NNP cord-266593-hmx2wy1p 63 15 et et NNP cord-266593-hmx2wy1p 63 16 al al NNP cord-266593-hmx2wy1p 63 17 . . NNP cord-266593-hmx2wy1p 63 18 , , , cord-266593-hmx2wy1p 63 19 2018 2018 CD cord-266593-hmx2wy1p 63 20 ) ) -RRB- cord-266593-hmx2wy1p 63 21 , , , cord-266593-hmx2wy1p 63 22 and and CC cord-266593-hmx2wy1p 63 23 optimal optimal JJ cord-266593-hmx2wy1p 63 24 design design NN cord-266593-hmx2wy1p 63 25 for for IN cord-266593-hmx2wy1p 63 26 such such JJ cord-266593-hmx2wy1p 63 27 ( ( -LRB- cord-266593-hmx2wy1p 63 28 Chaloner Chaloner NNP cord-266593-hmx2wy1p 63 29 and and CC cord-266593-hmx2wy1p 63 30 Verdinelli Verdinelli NNP cord-266593-hmx2wy1p 63 31 , , , cord-266593-hmx2wy1p 63 32 1995 1995 CD cord-266593-hmx2wy1p 63 33 ; ; : cord-266593-hmx2wy1p 63 34 Ryan Ryan NNP cord-266593-hmx2wy1p 63 35 et et NNP cord-266593-hmx2wy1p 63 36 al al NNP cord-266593-hmx2wy1p 63 37 . . NNP cord-266593-hmx2wy1p 63 38 , , , cord-266593-hmx2wy1p 63 39 2015 2015 CD cord-266593-hmx2wy1p 63 40 ) ) -RRB- cord-266593-hmx2wy1p 63 41 , , , cord-266593-hmx2wy1p 63 42 which which WDT cord-266593-hmx2wy1p 63 43 are be VBP cord-266593-hmx2wy1p 63 44 the the DT cord-266593-hmx2wy1p 63 45 most most RBS cord-266593-hmx2wy1p 63 46 appropriate appropriate JJ cord-266593-hmx2wy1p 63 47 tools tool NNS cord-266593-hmx2wy1p 63 48 and and CC cord-266593-hmx2wy1p 63 49 framework framework NN cord-266593-hmx2wy1p 63 50 to to TO cord-266593-hmx2wy1p 63 51 address address VB cord-266593-hmx2wy1p 63 52 this this DT cord-266593-hmx2wy1p 63 53 question question NN cord-266593-hmx2wy1p 63 54 . . . cord-266593-hmx2wy1p 64 1 A a DT cord-266593-hmx2wy1p 64 2 general general JJ cord-266593-hmx2wy1p 64 3 difficulty difficulty NN cord-266593-hmx2wy1p 64 4 with with IN cord-266593-hmx2wy1p 64 5 this this DT cord-266593-hmx2wy1p 64 6 theory theory NN cord-266593-hmx2wy1p 64 7 is be VBZ cord-266593-hmx2wy1p 64 8 that that DT cord-266593-hmx2wy1p 64 9 practical practical JJ cord-266593-hmx2wy1p 64 10 implementation implementation NN cord-266593-hmx2wy1p 64 11 is be VBZ cord-266593-hmx2wy1p 64 12 at at IN cord-266593-hmx2wy1p 64 13 best well RBS cord-266593-hmx2wy1p 64 14 difficult difficult JJ cord-266593-hmx2wy1p 64 15 , , , cord-266593-hmx2wy1p 64 16 and and CC cord-266593-hmx2wy1p 64 17 often often RB cord-266593-hmx2wy1p 64 18 infeasible infeasible JJ cord-266593-hmx2wy1p 64 19 . . . cord-266593-hmx2wy1p 65 1 This this DT cord-266593-hmx2wy1p 65 2 has have VBZ cord-266593-hmx2wy1p 65 3 led lead VBN cord-266593-hmx2wy1p 65 4 to to IN cord-266593-hmx2wy1p 65 5 methods method NNS cord-266593-hmx2wy1p 65 6 based base VBN cord-266593-hmx2wy1p 65 7 on on IN cord-266593-hmx2wy1p 65 8 approximate approximate JJ cord-266593-hmx2wy1p 65 9 Bayesian bayesian JJ cord-266593-hmx2wy1p 65 10 computation computation NN cord-266593-hmx2wy1p 65 11 ( ( -LRB- cord-266593-hmx2wy1p 65 12 ABC ABC NNP cord-266593-hmx2wy1p 65 13 ) ) -RRB- cord-266593-hmx2wy1p 65 14 , , , cord-266593-hmx2wy1p 65 15 which which WDT cord-266593-hmx2wy1p 65 16 requires require VBZ cord-266593-hmx2wy1p 65 17 only only JJ cord-266593-hmx2wy1p 65 18 simulation simulation NN cord-266593-hmx2wy1p 65 19 of of IN cord-266593-hmx2wy1p 65 20 realisations realisation NNS cord-266593-hmx2wy1p 65 21 from from IN cord-266593-hmx2wy1p 65 22 each each DT cord-266593-hmx2wy1p 65 23 model model NN cord-266593-hmx2wy1p 65 24 , , , cord-266593-hmx2wy1p 65 25 and and CC cord-266593-hmx2wy1p 65 26 is be VBZ cord-266593-hmx2wy1p 65 27 computationally computationally RB cord-266593-hmx2wy1p 65 28 feasible feasible JJ cord-266593-hmx2wy1p 65 29 for for IN cord-266593-hmx2wy1p 65 30 a a DT cord-266593-hmx2wy1p 65 31 wide wide JJ cord-266593-hmx2wy1p 65 32 range range NN cord-266593-hmx2wy1p 65 33 of of IN cord-266593-hmx2wy1p 65 34 models model NNS cord-266593-hmx2wy1p 65 35 . . . cord-266593-hmx2wy1p 66 1 Unfortunately unfortunately RB cord-266593-hmx2wy1p 66 2 , , , cord-266593-hmx2wy1p 66 3 there there EX cord-266593-hmx2wy1p 66 4 exists exist VBZ cord-266593-hmx2wy1p 66 5 ' ' `` cord-266593-hmx2wy1p 66 6 a a DT cord-266593-hmx2wy1p 66 7 fundamental fundamental JJ cord-266593-hmx2wy1p 66 8 difficulty difficulty NN cord-266593-hmx2wy1p 66 9 ' ' '' cord-266593-hmx2wy1p 66 10 in in IN cord-266593-hmx2wy1p 66 11 establishing establish VBG cord-266593-hmx2wy1p 66 12 robust robust JJ cord-266593-hmx2wy1p 66 13 methods method NNS cord-266593-hmx2wy1p 66 14 based base VBN cord-266593-hmx2wy1p 66 15 upon upon IN cord-266593-hmx2wy1p 66 16 summary summary NN cord-266593-hmx2wy1p 66 17 statistics statistic NNS cord-266593-hmx2wy1p 66 18 ( ( -LRB- cord-266593-hmx2wy1p 66 19 Robert Robert NNP cord-266593-hmx2wy1p 66 20 et et NNP cord-266593-hmx2wy1p 66 21 al al NNP cord-266593-hmx2wy1p 66 22 . . NNP cord-266593-hmx2wy1p 66 23 , , , cord-266593-hmx2wy1p 66 24 2011 2011 CD cord-266593-hmx2wy1p 66 25 ; ; : cord-266593-hmx2wy1p 66 26 Robert Robert NNP cord-266593-hmx2wy1p 66 27 , , , cord-266593-hmx2wy1p 66 28 2016 2016 CD cord-266593-hmx2wy1p 66 29 ) ) -RRB- cord-266593-hmx2wy1p 66 30 ; ; : cord-266593-hmx2wy1p 66 31 however however RB cord-266593-hmx2wy1p 66 32 , , , cord-266593-hmx2wy1p 66 33 see see VBP cord-266593-hmx2wy1p 66 34 the the DT cord-266593-hmx2wy1p 66 35 recent recent JJ cord-266593-hmx2wy1p 66 36 work work NN cord-266593-hmx2wy1p 66 37 of of IN cord-266593-hmx2wy1p 66 38 Dehideniya Dehideniya NNP cord-266593-hmx2wy1p 66 39 et et NNP cord-266593-hmx2wy1p 66 40 al al NNP cord-266593-hmx2wy1p 66 41 . . . cord-266593-hmx2wy1p 67 1 ( ( -LRB- cord-266593-hmx2wy1p 67 2 Dehideniya Dehideniya NNP cord-266593-hmx2wy1p 67 3 et et FW cord-266593-hmx2wy1p 67 4 al al NNP cord-266593-hmx2wy1p 67 5 . . NNP cord-266593-hmx2wy1p 67 6 , , , cord-266593-hmx2wy1p 67 7 2018 2018 CD cord-266593-hmx2wy1p 67 8 ) ) -RRB- cord-266593-hmx2wy1p 67 9 . . . cord-266593-hmx2wy1p 68 1 Another another DT cord-266593-hmx2wy1p 68 2 approach approach NN cord-266593-hmx2wy1p 68 3 to to TO cord-266593-hmx2wy1p 68 4 model model VB cord-266593-hmx2wy1p 68 5 discrimination discrimination NN cord-266593-hmx2wy1p 68 6 in in IN cord-266593-hmx2wy1p 68 7 an an DT cord-266593-hmx2wy1p 68 8 ABC ABC NNP cord-266593-hmx2wy1p 68 9 framework framework NN cord-266593-hmx2wy1p 68 10 has have VBZ cord-266593-hmx2wy1p 68 11 been be VBN cord-266593-hmx2wy1p 68 12 proposed propose VBN cord-266593-hmx2wy1p 68 13 by by IN cord-266593-hmx2wy1p 68 14 Pudlo Pudlo NNP cord-266593-hmx2wy1p 68 15 et et FW cord-266593-hmx2wy1p 68 16 al al NNP cord-266593-hmx2wy1p 68 17 . . . cord-266593-hmx2wy1p 69 1 ( ( -LRB- cord-266593-hmx2wy1p 69 2 Pudlo Pudlo NNP cord-266593-hmx2wy1p 69 3 et et FW cord-266593-hmx2wy1p 69 4 al al NNP cord-266593-hmx2wy1p 69 5 . . NNP cord-266593-hmx2wy1p 69 6 , , , cord-266593-hmx2wy1p 69 7 2015 2015 CD cord-266593-hmx2wy1p 69 8 ) ) -RRB- cord-266593-hmx2wy1p 69 9 . . . cord-266593-hmx2wy1p 70 1 They -PRON- PRP cord-266593-hmx2wy1p 70 2 treat treat VBP cord-266593-hmx2wy1p 70 3 model model NN cord-266593-hmx2wy1p 70 4 discrimination discrimination NN cord-266593-hmx2wy1p 70 5 as as IN cord-266593-hmx2wy1p 70 6 a a DT cord-266593-hmx2wy1p 70 7 classification classification NN cord-266593-hmx2wy1p 70 8 problem problem NN cord-266593-hmx2wy1p 70 9 , , , cord-266593-hmx2wy1p 70 10 for for IN cord-266593-hmx2wy1p 70 11 which which WDT cord-266593-hmx2wy1p 70 12 machine machine NN cord-266593-hmx2wy1p 70 13 learning learning NN cord-266593-hmx2wy1p 70 14 methods method NNS cord-266593-hmx2wy1p 70 15 are be VBP cord-266593-hmx2wy1p 70 16 ideal ideal JJ cord-266593-hmx2wy1p 70 17 , , , cord-266593-hmx2wy1p 70 18 and and CC cord-266593-hmx2wy1p 70 19 in in IN cord-266593-hmx2wy1p 70 20 particular particular JJ cord-266593-hmx2wy1p 70 21 propose propose VB cord-266593-hmx2wy1p 70 22 the the DT cord-266593-hmx2wy1p 70 23 use use NN cord-266593-hmx2wy1p 70 24 of of IN cord-266593-hmx2wy1p 70 25 random random JJ cord-266593-hmx2wy1p 70 26 forests forest NNS cord-266593-hmx2wy1p 70 27 to to TO cord-266593-hmx2wy1p 70 28 perform perform VB cord-266593-hmx2wy1p 70 29 this this DT cord-266593-hmx2wy1p 70 30 task task NN cord-266593-hmx2wy1p 70 31 . . . cord-266593-hmx2wy1p 71 1 This this DT cord-266593-hmx2wy1p 71 2 approach approach NN cord-266593-hmx2wy1p 71 3 provides provide VBZ cord-266593-hmx2wy1p 71 4 a a DT cord-266593-hmx2wy1p 71 5 highly highly RB cord-266593-hmx2wy1p 71 6 - - HYPH cord-266593-hmx2wy1p 71 7 efficient efficient JJ cord-266593-hmx2wy1p 71 8 , , , cord-266593-hmx2wy1p 71 9 and and CC cord-266593-hmx2wy1p 71 10 importantly importantly RB cord-266593-hmx2wy1p 71 11 , , , cord-266593-hmx2wy1p 71 12 robust robust JJ cord-266593-hmx2wy1p 71 13 method method NN cord-266593-hmx2wy1p 71 14 for for IN cord-266593-hmx2wy1p 71 15 model model NN cord-266593-hmx2wy1p 71 16 discrimination discrimination NN cord-266593-hmx2wy1p 71 17 . . . cord-266593-hmx2wy1p 72 1 Hainy Hainy NNP cord-266593-hmx2wy1p 72 2 et et NNP cord-266593-hmx2wy1p 72 3 al al NNP cord-266593-hmx2wy1p 72 4 . . . cord-266593-hmx2wy1p 73 1 ( ( -LRB- cord-266593-hmx2wy1p 73 2 Hainy Hainy NNP cord-266593-hmx2wy1p 73 3 et et NNP cord-266593-hmx2wy1p 73 4 al al NNP cord-266593-hmx2wy1p 73 5 . . NNP cord-266593-hmx2wy1p 73 6 , , , cord-266593-hmx2wy1p 73 7 2018 2018 CD cord-266593-hmx2wy1p 73 8 ) ) -RRB- cord-266593-hmx2wy1p 73 9 expand expand VB cord-266593-hmx2wy1p 73 10 on on IN cord-266593-hmx2wy1p 73 11 this this DT cord-266593-hmx2wy1p 73 12 approach approach NN cord-266593-hmx2wy1p 73 13 as as IN cord-266593-hmx2wy1p 73 14 specifically specifically RB cord-266593-hmx2wy1p 73 15 applied apply VBN cord-266593-hmx2wy1p 73 16 to to IN cord-266593-hmx2wy1p 73 17 optimal optimal JJ cord-266593-hmx2wy1p 73 18 design design NN cord-266593-hmx2wy1p 73 19 for for IN cord-266593-hmx2wy1p 73 20 model model NN cord-266593-hmx2wy1p 73 21 discrimination discrimination NN cord-266593-hmx2wy1p 73 22 . . . cord-266593-hmx2wy1p 74 1 We -PRON- PRP cord-266593-hmx2wy1p 74 2 apply apply VBP cord-266593-hmx2wy1p 74 3 random random JJ cord-266593-hmx2wy1p 74 4 - - HYPH cord-266593-hmx2wy1p 74 5 forest forest NN cord-266593-hmx2wy1p 74 6 based base VBN cord-266593-hmx2wy1p 74 7 Bayesian bayesian JJ cord-266593-hmx2wy1p 74 8 model model NN cord-266593-hmx2wy1p 74 9 discrimination discrimination NN cord-266593-hmx2wy1p 74 10 , , , cord-266593-hmx2wy1p 74 11 first first RB cord-266593-hmx2wy1p 74 12 for for IN cord-266593-hmx2wy1p 74 13 accurate accurate JJ cord-266593-hmx2wy1p 74 14 , , , cord-266593-hmx2wy1p 74 15 robust robust JJ cord-266593-hmx2wy1p 74 16 characterisation characterisation NN cord-266593-hmx2wy1p 74 17 of of IN cord-266593-hmx2wy1p 74 18 relative relative JJ cord-266593-hmx2wy1p 74 19 timing timing NN cord-266593-hmx2wy1p 74 20 of of IN cord-266593-hmx2wy1p 74 21 symptoms symptom NNS cord-266593-hmx2wy1p 74 22 and and CC cord-266593-hmx2wy1p 74 23 infectiousness infectiousness NN cord-266593-hmx2wy1p 74 24 , , , cord-266593-hmx2wy1p 74 25 and and CC cord-266593-hmx2wy1p 74 26 second second RB cord-266593-hmx2wy1p 74 27 , , , cord-266593-hmx2wy1p 74 28 for for IN cord-266593-hmx2wy1p 74 29 optimal optimal JJ cord-266593-hmx2wy1p 74 30 design design NN cord-266593-hmx2wy1p 74 31 of of IN cord-266593-hmx2wy1p 74 32 early early JJ cord-266593-hmx2wy1p 74 33 outbreak outbreak NN cord-266593-hmx2wy1p 74 34 surveillance surveillance NN cord-266593-hmx2wy1p 74 35 for for IN cord-266593-hmx2wy1p 74 36 accurate accurate JJ cord-266593-hmx2wy1p 74 37 model model NN cord-266593-hmx2wy1p 74 38 discrimination discrimination NN cord-266593-hmx2wy1p 74 39 . . . cord-266593-hmx2wy1p 75 1 Specifically specifically RB cord-266593-hmx2wy1p 75 2 , , , cord-266593-hmx2wy1p 75 3 the the DT cord-266593-hmx2wy1p 75 4 aim aim NN cord-266593-hmx2wy1p 75 5 of of IN cord-266593-hmx2wy1p 75 6 the the DT cord-266593-hmx2wy1p 75 7 latter latter JJ cord-266593-hmx2wy1p 75 8 is be VBZ cord-266593-hmx2wy1p 75 9 to to TO cord-266593-hmx2wy1p 75 10 select select VB cord-266593-hmx2wy1p 75 11 an an DT cord-266593-hmx2wy1p 75 12 optimal optimal JJ cord-266593-hmx2wy1p 75 13 surveillance surveillance NN cord-266593-hmx2wy1p 75 14 scheme scheme NN cord-266593-hmx2wy1p 75 15 , , , cord-266593-hmx2wy1p 75 16 consisting consist VBG cord-266593-hmx2wy1p 75 17 of of IN cord-266593-hmx2wy1p 75 18 a a DT cord-266593-hmx2wy1p 75 19 fixed fix VBN cord-266593-hmx2wy1p 75 20 number number NN cord-266593-hmx2wy1p 75 21 of of IN cord-266593-hmx2wy1p 75 22 observations observation NNS cord-266593-hmx2wy1p 75 23 , , , cord-266593-hmx2wy1p 75 24 in in IN cord-266593-hmx2wy1p 75 25 order order NN cord-266593-hmx2wy1p 75 26 to to TO cord-266593-hmx2wy1p 75 27 discriminate discriminate VB cord-266593-hmx2wy1p 75 28 five five CD cord-266593-hmx2wy1p 75 29 different different JJ cord-266593-hmx2wy1p 75 30 timings timing NNS cord-266593-hmx2wy1p 75 31 of of IN cord-266593-hmx2wy1p 75 32 symptom symptom NN cord-266593-hmx2wy1p 75 33 onset onset NN cord-266593-hmx2wy1p 75 34 relative relative NN cord-266593-hmx2wy1p 75 35 to to IN cord-266593-hmx2wy1p 75 36 infectiousness infectiousness NN cord-266593-hmx2wy1p 75 37 , , , cord-266593-hmx2wy1p 75 38 within within IN cord-266593-hmx2wy1p 75 39 a a DT cord-266593-hmx2wy1p 75 40 household household NN cord-266593-hmx2wy1p 75 41 - - HYPH cord-266593-hmx2wy1p 75 42 stratified stratify VBN cord-266593-hmx2wy1p 75 43 epidemic epidemic NN cord-266593-hmx2wy1p 75 44 model model NN cord-266593-hmx2wy1p 75 45 . . . cord-266593-hmx2wy1p 76 1 We -PRON- PRP cord-266593-hmx2wy1p 76 2 evaluate evaluate VBP cord-266593-hmx2wy1p 76 3 , , , cord-266593-hmx2wy1p 76 4 using use VBG cord-266593-hmx2wy1p 76 5 simulated simulate VBN cord-266593-hmx2wy1p 76 6 data datum NNS cord-266593-hmx2wy1p 76 7 , , , cord-266593-hmx2wy1p 76 8 the the DT cord-266593-hmx2wy1p 76 9 impact impact NN cord-266593-hmx2wy1p 76 10 of of IN cord-266593-hmx2wy1p 76 11 assumptions assumption NNS cord-266593-hmx2wy1p 76 12 and and CC cord-266593-hmx2wy1p 76 13 summary summary NN cord-266593-hmx2wy1p 76 14 statistics statistic NNS cord-266593-hmx2wy1p 76 15 . . . cord-266593-hmx2wy1p 77 1 Additionally additionally RB cord-266593-hmx2wy1p 77 2 , , , cord-266593-hmx2wy1p 77 3 we -PRON- PRP cord-266593-hmx2wy1p 77 4 propose propose VBP cord-266593-hmx2wy1p 77 5 a a DT cord-266593-hmx2wy1p 77 6 new new JJ cord-266593-hmx2wy1p 77 7 , , , cord-266593-hmx2wy1p 77 8 computationally computationally RB cord-266593-hmx2wy1p 77 9 - - HYPH cord-266593-hmx2wy1p 77 10 efficient efficient JJ cord-266593-hmx2wy1p 77 11 and and CC cord-266593-hmx2wy1p 77 12 highly highly RB cord-266593-hmx2wy1p 77 13 - - HYPH cord-266593-hmx2wy1p 77 14 accurate accurate JJ cord-266593-hmx2wy1p 77 15 heuristic heuristic NN cord-266593-hmx2wy1p 77 16 for for IN cord-266593-hmx2wy1p 77 17 optimal optimal JJ cord-266593-hmx2wy1p 77 18 design design NN cord-266593-hmx2wy1p 77 19 choice choice NN cord-266593-hmx2wy1p 77 20 , , , cord-266593-hmx2wy1p 77 21 which which WDT cord-266593-hmx2wy1p 77 22 in in IN cord-266593-hmx2wy1p 77 23 this this DT cord-266593-hmx2wy1p 77 24 application application NN cord-266593-hmx2wy1p 77 25 determines determine VBZ cord-266593-hmx2wy1p 77 26 the the DT cord-266593-hmx2wy1p 77 27 optimal optimal JJ cord-266593-hmx2wy1p 77 28 days day NNS cord-266593-hmx2wy1p 77 29 upon upon IN cord-266593-hmx2wy1p 77 30 which which WDT cord-266593-hmx2wy1p 77 31 to to TO cord-266593-hmx2wy1p 77 32 perform perform VB cord-266593-hmx2wy1p 77 33 surveillance surveillance NN cord-266593-hmx2wy1p 77 34 in in IN cord-266593-hmx2wy1p 77 35 households household NNS cord-266593-hmx2wy1p 77 36 . . . cord-266593-hmx2wy1p 78 1 We -PRON- PRP cord-266593-hmx2wy1p 78 2 demonstrate demonstrate VBP cord-266593-hmx2wy1p 78 3 using use VBG cord-266593-hmx2wy1p 78 4 an an DT cord-266593-hmx2wy1p 78 5 example example NN cord-266593-hmx2wy1p 78 6 system system NN cord-266593-hmx2wy1p 78 7 of of IN cord-266593-hmx2wy1p 78 8 a a DT cord-266593-hmx2wy1p 78 9 novel novel JJ cord-266593-hmx2wy1p 78 10 infectious infectious JJ cord-266593-hmx2wy1p 78 11 disease disease NN cord-266593-hmx2wy1p 78 12 , , , cord-266593-hmx2wy1p 78 13 spreading spread VBG cord-266593-hmx2wy1p 78 14 in in IN cord-266593-hmx2wy1p 78 15 a a DT cord-266593-hmx2wy1p 78 16 population population NN cord-266593-hmx2wy1p 78 17 structured structure VBN cord-266593-hmx2wy1p 78 18 into into IN cord-266593-hmx2wy1p 78 19 households household NNS cord-266593-hmx2wy1p 78 20 . . . cord-266593-hmx2wy1p 79 1 We -PRON- PRP cord-266593-hmx2wy1p 79 2 assume assume VBP cord-266593-hmx2wy1p 79 3 that that IN cord-266593-hmx2wy1p 79 4 the the DT cord-266593-hmx2wy1p 79 5 population population NN cord-266593-hmx2wy1p 79 6 is be VBZ cord-266593-hmx2wy1p 79 7 large large JJ cord-266593-hmx2wy1p 79 8 and and CC cord-266593-hmx2wy1p 79 9 mixing mix VBG cord-266593-hmx2wy1p 79 10 between between IN cord-266593-hmx2wy1p 79 11 households household NNS cord-266593-hmx2wy1p 79 12 is be VBZ cord-266593-hmx2wy1p 79 13 random random JJ cord-266593-hmx2wy1p 79 14 , , , cord-266593-hmx2wy1p 79 15 such such JJ cord-266593-hmx2wy1p 79 16 that that IN cord-266593-hmx2wy1p 79 17 after after IN cord-266593-hmx2wy1p 79 18 a a DT cord-266593-hmx2wy1p 79 19 household household NN cord-266593-hmx2wy1p 79 20 is be VBZ cord-266593-hmx2wy1p 79 21 initially initially RB cord-266593-hmx2wy1p 79 22 infected infect VBN cord-266593-hmx2wy1p 79 23 , , , cord-266593-hmx2wy1p 79 24 Table table NN cord-266593-hmx2wy1p 79 25 1 1 CD cord-266593-hmx2wy1p 79 26 Events event NNS cord-266593-hmx2wy1p 79 27 , , , cord-266593-hmx2wy1p 79 28 transitions transition NNS cord-266593-hmx2wy1p 79 29 and and CC cord-266593-hmx2wy1p 79 30 rates rate NNS cord-266593-hmx2wy1p 79 31 within within IN cord-266593-hmx2wy1p 79 32 a a DT cord-266593-hmx2wy1p 79 33 household household NN cord-266593-hmx2wy1p 79 34 . . . cord-266593-hmx2wy1p 80 1 N N NNP cord-266593-hmx2wy1p 80 2 is be VBZ cord-266593-hmx2wy1p 80 3 the the DT cord-266593-hmx2wy1p 80 4 ( ( -LRB- cord-266593-hmx2wy1p 80 5 fixed fixed JJ cord-266593-hmx2wy1p 80 6 ) ) -RRB- cord-266593-hmx2wy1p 80 7 household household NN cord-266593-hmx2wy1p 80 8 size size NN cord-266593-hmx2wy1p 80 9 , , , cord-266593-hmx2wy1p 80 10 β β NN cord-266593-hmx2wy1p 80 11 , , , cord-266593-hmx2wy1p 80 12 γ γ NNP cord-266593-hmx2wy1p 80 13 and and CC cord-266593-hmx2wy1p 80 14 σ σ NNP cord-266593-hmx2wy1p 80 15 are be VBP cord-266593-hmx2wy1p 80 16 the the DT cord-266593-hmx2wy1p 80 17 rates rate NNS cord-266593-hmx2wy1p 80 18 of of IN cord-266593-hmx2wy1p 80 19 infection infection NN cord-266593-hmx2wy1p 80 20 , , , cord-266593-hmx2wy1p 80 21 gaining gain VBG cord-266593-hmx2wy1p 80 22 infectiousness infectiousness NN cord-266593-hmx2wy1p 80 23 and and CC cord-266593-hmx2wy1p 80 24 recovery recovery NN cord-266593-hmx2wy1p 80 25 , , , cord-266593-hmx2wy1p 80 26 respectively respectively RB cord-266593-hmx2wy1p 80 27 . . . cord-266593-hmx2wy1p 81 1 Transition transition NN cord-266593-hmx2wy1p 81 2 Rate rate NN cord-266593-hmx2wy1p 82 1 the the DT cord-266593-hmx2wy1p 82 2 remaining remain VBG cord-266593-hmx2wy1p 82 3 transmission transmission NN cord-266593-hmx2wy1p 82 4 within within IN cord-266593-hmx2wy1p 82 5 the the DT cord-266593-hmx2wy1p 82 6 household household NN cord-266593-hmx2wy1p 82 7 is be VBZ cord-266593-hmx2wy1p 82 8 independent independent JJ cord-266593-hmx2wy1p 82 9 of of IN cord-266593-hmx2wy1p 82 10 transmission transmission NN cord-266593-hmx2wy1p 82 11 outside outside IN cord-266593-hmx2wy1p 82 12 the the DT cord-266593-hmx2wy1p 82 13 household household NN cord-266593-hmx2wy1p 83 1 ( ( -LRB- cord-266593-hmx2wy1p 83 2 Ross Ross NNP cord-266593-hmx2wy1p 83 3 et et NNP cord-266593-hmx2wy1p 83 4 al al NNP cord-266593-hmx2wy1p 83 5 . . NNP cord-266593-hmx2wy1p 83 6 , , , cord-266593-hmx2wy1p 83 7 2010 2010 CD cord-266593-hmx2wy1p 83 8 ; ; : cord-266593-hmx2wy1p 83 9 Black Black NNP cord-266593-hmx2wy1p 83 10 et et NNP cord-266593-hmx2wy1p 83 11 al al NNP cord-266593-hmx2wy1p 83 12 . . NNP cord-266593-hmx2wy1p 83 13 , , , cord-266593-hmx2wy1p 83 14 2013 2013 CD cord-266593-hmx2wy1p 83 15 ) ) -RRB- cord-266593-hmx2wy1p 83 16 . . . cord-266593-hmx2wy1p 84 1 Therefore therefore RB cord-266593-hmx2wy1p 84 2 , , , cord-266593-hmx2wy1p 84 3 transmission transmission NN cord-266593-hmx2wy1p 84 4 dynamics dynamic NNS cord-266593-hmx2wy1p 84 5 within within IN cord-266593-hmx2wy1p 84 6 households household NNS cord-266593-hmx2wy1p 84 7 can can MD cord-266593-hmx2wy1p 84 8 be be VB cord-266593-hmx2wy1p 84 9 modelled model VBN cord-266593-hmx2wy1p 84 10 independently independently RB cord-266593-hmx2wy1p 84 11 , , , cord-266593-hmx2wy1p 84 12 i.e. i.e. FW cord-266593-hmx2wy1p 84 13 , , , cord-266593-hmx2wy1p 84 14 with with IN cord-266593-hmx2wy1p 84 15 infection infection NN cord-266593-hmx2wy1p 84 16 only only RB cord-266593-hmx2wy1p 84 17 occurring occur VBG cord-266593-hmx2wy1p 84 18 between between IN cord-266593-hmx2wy1p 84 19 individuals individual NNS cord-266593-hmx2wy1p 84 20 within within IN cord-266593-hmx2wy1p 84 21 a a DT cord-266593-hmx2wy1p 84 22 household household NN cord-266593-hmx2wy1p 84 23 , , , cord-266593-hmx2wy1p 84 24 rather rather RB cord-266593-hmx2wy1p 84 25 than than IN cord-266593-hmx2wy1p 84 26 between between IN cord-266593-hmx2wy1p 84 27 households household NNS cord-266593-hmx2wy1p 84 28 . . . cord-266593-hmx2wy1p 85 1 Note note VB cord-266593-hmx2wy1p 85 2 that that IN cord-266593-hmx2wy1p 85 3 this this DT cord-266593-hmx2wy1p 85 4 is be VBZ cord-266593-hmx2wy1p 85 5 an an DT cord-266593-hmx2wy1p 85 6 assumption assumption NN cord-266593-hmx2wy1p 85 7 which which WDT cord-266593-hmx2wy1p 85 8 simplifies simplify VBZ cord-266593-hmx2wy1p 85 9 the the DT cord-266593-hmx2wy1p 85 10 simulation simulation NN cord-266593-hmx2wy1p 85 11 process process NN cord-266593-hmx2wy1p 85 12 , , , cord-266593-hmx2wy1p 85 13 but but CC cord-266593-hmx2wy1p 85 14 it -PRON- PRP cord-266593-hmx2wy1p 85 15 could could MD cord-266593-hmx2wy1p 85 16 be be VB cord-266593-hmx2wy1p 85 17 modified modify VBN cord-266593-hmx2wy1p 85 18 if if IN cord-266593-hmx2wy1p 85 19 necessary necessary JJ cord-266593-hmx2wy1p 85 20 . . . cord-266593-hmx2wy1p 86 1 Given give VBN cord-266593-hmx2wy1p 86 2 this this DT cord-266593-hmx2wy1p 86 3 novel novel JJ cord-266593-hmx2wy1p 86 4 etiological etiological JJ cord-266593-hmx2wy1p 86 5 agent agent NN cord-266593-hmx2wy1p 86 6 , , , cord-266593-hmx2wy1p 86 7 we -PRON- PRP cord-266593-hmx2wy1p 86 8 wish wish VBP cord-266593-hmx2wy1p 86 9 to to TO cord-266593-hmx2wy1p 86 10 determine determine VB cord-266593-hmx2wy1p 86 11 if if IN cord-266593-hmx2wy1p 86 12 symptom symptom NN cord-266593-hmx2wy1p 86 13 onset onset NN cord-266593-hmx2wy1p 86 14 occurs occur VBZ cord-266593-hmx2wy1p 86 15 at at IN cord-266593-hmx2wy1p 86 16 the the DT cord-266593-hmx2wy1p 86 17 time time NN cord-266593-hmx2wy1p 86 18 of of IN cord-266593-hmx2wy1p 86 19 infection infection NN cord-266593-hmx2wy1p 86 20 , , , cord-266593-hmx2wy1p 86 21 between between IN cord-266593-hmx2wy1p 86 22 infection infection NN cord-266593-hmx2wy1p 86 23 and and CC cord-266593-hmx2wy1p 86 24 infectiousness infectiousness NN cord-266593-hmx2wy1p 86 25 , , , cord-266593-hmx2wy1p 86 26 coincident coincident JJ cord-266593-hmx2wy1p 86 27 with with IN cord-266593-hmx2wy1p 86 28 infectiousness infectiousness NN cord-266593-hmx2wy1p 86 29 , , , cord-266593-hmx2wy1p 86 30 after after IN cord-266593-hmx2wy1p 86 31 infectiousness infectiousness NN cord-266593-hmx2wy1p 86 32 , , , cord-266593-hmx2wy1p 86 33 or or CC cord-266593-hmx2wy1p 86 34 coincident coincident JJ cord-266593-hmx2wy1p 86 35 with with IN cord-266593-hmx2wy1p 86 36 recovery recovery NN cord-266593-hmx2wy1p 86 37 ( ( -LRB- cord-266593-hmx2wy1p 86 38 i.e. i.e. FW cord-266593-hmx2wy1p 86 39 , , , cord-266593-hmx2wy1p 86 40 these these DT cord-266593-hmx2wy1p 86 41 are be VBP cord-266593-hmx2wy1p 86 42 the the DT cord-266593-hmx2wy1p 86 43 five five CD cord-266593-hmx2wy1p 86 44 candidate candidate NN cord-266593-hmx2wy1p 86 45 models model NNS cord-266593-hmx2wy1p 86 46 we -PRON- PRP cord-266593-hmx2wy1p 86 47 wish wish VBP cord-266593-hmx2wy1p 86 48 to to TO cord-266593-hmx2wy1p 86 49 discriminate discriminate VB cord-266593-hmx2wy1p 86 50 ) ) -RRB- cord-266593-hmx2wy1p 86 51 . . . cord-266593-hmx2wy1p 87 1 The the DT cord-266593-hmx2wy1p 87 2 model model NN cord-266593-hmx2wy1p 87 3 behaviours behaviour NNS cord-266593-hmx2wy1p 87 4 are be VBP cord-266593-hmx2wy1p 87 5 otherwise otherwise RB cord-266593-hmx2wy1p 87 6 assumed assume VBN cord-266593-hmx2wy1p 87 7 identical identical JJ cord-266593-hmx2wy1p 87 8 . . . cord-266593-hmx2wy1p 88 1 To to TO cord-266593-hmx2wy1p 88 2 be be VB cord-266593-hmx2wy1p 88 3 emphatic emphatic JJ cord-266593-hmx2wy1p 88 4 , , , cord-266593-hmx2wy1p 88 5 the the DT cord-266593-hmx2wy1p 88 6 underlying underlie VBG cord-266593-hmx2wy1p 88 7 disease disease NN cord-266593-hmx2wy1p 88 8 dynamics dynamic NNS cord-266593-hmx2wy1p 88 9 is be VBZ cord-266593-hmx2wy1p 88 10 identical identical JJ cord-266593-hmx2wy1p 88 11 in in IN cord-266593-hmx2wy1p 88 12 all all DT cord-266593-hmx2wy1p 88 13 five five CD cord-266593-hmx2wy1p 88 14 models model NNS cord-266593-hmx2wy1p 88 15 , , , cord-266593-hmx2wy1p 88 16 each each DT cord-266593-hmx2wy1p 88 17 differing differ VBG cord-266593-hmx2wy1p 88 18 only only RB cord-266593-hmx2wy1p 88 19 in in IN cord-266593-hmx2wy1p 88 20 when when WRB cord-266593-hmx2wy1p 88 21 observations observation NNS cord-266593-hmx2wy1p 88 22 are be VBP cord-266593-hmx2wy1p 88 23 made make VBN cord-266593-hmx2wy1p 88 24 , , , cord-266593-hmx2wy1p 88 25 corresponding correspond VBG cord-266593-hmx2wy1p 88 26 to to IN cord-266593-hmx2wy1p 88 27 different different JJ cord-266593-hmx2wy1p 88 28 timings timing NNS cord-266593-hmx2wy1p 88 29 of of IN cord-266593-hmx2wy1p 88 30 symptom symptom NN cord-266593-hmx2wy1p 88 31 onset onset NN cord-266593-hmx2wy1p 89 1 ( ( -LRB- cord-266593-hmx2wy1p 89 2 Fig Fig NNP cord-266593-hmx2wy1p 89 3 . . . cord-266593-hmx2wy1p 89 4 1 1 CD cord-266593-hmx2wy1p 89 5 a a LS cord-266593-hmx2wy1p 89 6 ) ) -RRB- cord-266593-hmx2wy1p 89 7 . . . cord-266593-hmx2wy1p 90 1 We -PRON- PRP cord-266593-hmx2wy1p 90 2 focus focus VBP cord-266593-hmx2wy1p 90 3 on on IN cord-266593-hmx2wy1p 90 4 selecting select VBG cord-266593-hmx2wy1p 90 5 between between IN cord-266593-hmx2wy1p 90 6 these these DT cord-266593-hmx2wy1p 90 7 observation observation NN cord-266593-hmx2wy1p 90 8 models model NNS cord-266593-hmx2wy1p 90 9 as as IN cord-266593-hmx2wy1p 90 10 the the DT cord-266593-hmx2wy1p 90 11 relative relative JJ cord-266593-hmx2wy1p 90 12 timing timing NN cord-266593-hmx2wy1p 90 13 of of IN cord-266593-hmx2wy1p 90 14 infectiousness infectiousness NN cord-266593-hmx2wy1p 90 15 and and CC cord-266593-hmx2wy1p 90 16 symptom symptom NN cord-266593-hmx2wy1p 90 17 onset onset NN cord-266593-hmx2wy1p 90 18 is be VBZ cord-266593-hmx2wy1p 90 19 critical critical JJ cord-266593-hmx2wy1p 90 20 to to IN cord-266593-hmx2wy1p 90 21 effective effective JJ cord-266593-hmx2wy1p 90 22 outbreak outbreak NN cord-266593-hmx2wy1p 90 23 management management NN cord-266593-hmx2wy1p 90 24 : : : cord-266593-hmx2wy1p 90 25 quarantine quarantine NN cord-266593-hmx2wy1p 90 26 can can MD cord-266593-hmx2wy1p 90 27 be be VB cord-266593-hmx2wy1p 90 28 applied apply VBN cord-266593-hmx2wy1p 90 29 effectively effectively RB cord-266593-hmx2wy1p 90 30 if if IN cord-266593-hmx2wy1p 90 31 symptoms symptom NNS cord-266593-hmx2wy1p 90 32 occur occur VBP cord-266593-hmx2wy1p 90 33 before before RB cord-266593-hmx2wy1p 90 34 ( ( -LRB- cord-266593-hmx2wy1p 90 35 or or CC cord-266593-hmx2wy1p 90 36 possibly possibly RB cord-266593-hmx2wy1p 90 37 coincident coincident JJ cord-266593-hmx2wy1p 90 38 to to IN cord-266593-hmx2wy1p 90 39 ) ) -RRB- cord-266593-hmx2wy1p 90 40 infectiousness infectiousness NN cord-266593-hmx2wy1p 90 41 . . . cord-266593-hmx2wy1p 91 1 We -PRON- PRP cord-266593-hmx2wy1p 91 2 model model VBP cord-266593-hmx2wy1p 91 3 the the DT cord-266593-hmx2wy1p 91 4 epidemic epidemic NN cord-266593-hmx2wy1p 91 5 dynamics dynamic NNS cord-266593-hmx2wy1p 91 6 in in IN cord-266593-hmx2wy1p 91 7 households household NNS cord-266593-hmx2wy1p 91 8 as as IN cord-266593-hmx2wy1p 91 9 a a DT cord-266593-hmx2wy1p 91 10 continuous continuous JJ cord-266593-hmx2wy1p 91 11 - - HYPH cord-266593-hmx2wy1p 91 12 time time NN cord-266593-hmx2wy1p 91 13 Markov Markov NNP cord-266593-hmx2wy1p 91 14 chain chain NN cord-266593-hmx2wy1p 91 15 ( ( -LRB- cord-266593-hmx2wy1p 91 16 Figure figure NN cord-266593-hmx2wy1p 91 17 1a 1a CD cord-266593-hmx2wy1p 91 18 ) ) -RRB- cord-266593-hmx2wy1p 92 1 ( ( -LRB- cord-266593-hmx2wy1p 92 2 Keeling Keeling NNP cord-266593-hmx2wy1p 92 3 and and CC cord-266593-hmx2wy1p 92 4 Ross Ross NNP cord-266593-hmx2wy1p 92 5 , , , cord-266593-hmx2wy1p 92 6 2008 2008 CD cord-266593-hmx2wy1p 92 7 ) ) -RRB- cord-266593-hmx2wy1p 92 8 . . . cord-266593-hmx2wy1p 93 1 Individuals individual NNS cord-266593-hmx2wy1p 93 2 transition transition VBP cord-266593-hmx2wy1p 93 3 from from IN cord-266593-hmx2wy1p 93 4 susceptible susceptible JJ cord-266593-hmx2wy1p 93 5 ( ( -LRB- cord-266593-hmx2wy1p 93 6 S s NN cord-266593-hmx2wy1p 93 7 ) ) -RRB- cord-266593-hmx2wy1p 93 8 to to IN cord-266593-hmx2wy1p 93 9 exposed expose VBN cord-266593-hmx2wy1p 93 10 ( ( -LRB- cord-266593-hmx2wy1p 93 11 E E NNP cord-266593-hmx2wy1p 93 12 1 1 CD cord-266593-hmx2wy1p 93 13 , , , cord-266593-hmx2wy1p 93 14 and and CC cord-266593-hmx2wy1p 93 15 subsequently subsequently RB cord-266593-hmx2wy1p 93 16 E E NNP cord-266593-hmx2wy1p 93 17 2 2 CD cord-266593-hmx2wy1p 93 18 ) ) -RRB- cord-266593-hmx2wy1p 93 19 , , , cord-266593-hmx2wy1p 93 20 then then RB cord-266593-hmx2wy1p 93 21 to to IN cord-266593-hmx2wy1p 93 22 infectious infectious JJ cord-266593-hmx2wy1p 93 23 ( ( -LRB- cord-266593-hmx2wy1p 93 24 I i NN cord-266593-hmx2wy1p 93 25 1 1 CD cord-266593-hmx2wy1p 93 26 , , , cord-266593-hmx2wy1p 93 27 and and CC cord-266593-hmx2wy1p 93 28 subsequently subsequently RB cord-266593-hmx2wy1p 93 29 I -PRON- PRP cord-266593-hmx2wy1p 93 30 2 2 CD cord-266593-hmx2wy1p 93 31 ) ) -RRB- cord-266593-hmx2wy1p 93 32 , , , cord-266593-hmx2wy1p 93 33 and and CC cord-266593-hmx2wy1p 93 34 finally finally RB cord-266593-hmx2wy1p 93 35 to to TO cord-266593-hmx2wy1p 93 36 recovered recover VBN cord-266593-hmx2wy1p 93 37 ( ( -LRB- cord-266593-hmx2wy1p 93 38 R r NN cord-266593-hmx2wy1p 93 39 ) ) -RRB- cord-266593-hmx2wy1p 93 40 , , , cord-266593-hmx2wy1p 93 41 with with IN cord-266593-hmx2wy1p 93 42 rates rate NNS cord-266593-hmx2wy1p 93 43 as as IN cord-266593-hmx2wy1p 93 44 described describe VBN cord-266593-hmx2wy1p 93 45 in in IN cord-266593-hmx2wy1p 93 46 Table Table NNP cord-266593-hmx2wy1p 93 47 1 1 CD cord-266593-hmx2wy1p 93 48 . . . cord-266593-hmx2wy1p 94 1 The the DT cord-266593-hmx2wy1p 94 2 model model NN cord-266593-hmx2wy1p 94 3 dynamics dynamic NNS cord-266593-hmx2wy1p 94 4 are be VBP cord-266593-hmx2wy1p 94 5 general general JJ cord-266593-hmx2wy1p 94 6 , , , cord-266593-hmx2wy1p 94 7 but but CC cord-266593-hmx2wy1p 94 8 explicitly explicitly RB cord-266593-hmx2wy1p 94 9 resemble resemble VB cord-266593-hmx2wy1p 94 10 the the DT cord-266593-hmx2wy1p 94 11 dynamics dynamic NNS cord-266593-hmx2wy1p 94 12 of of IN cord-266593-hmx2wy1p 94 13 a a DT cord-266593-hmx2wy1p 94 14 respiratory respiratory JJ cord-266593-hmx2wy1p 94 15 virus virus NN cord-266593-hmx2wy1p 94 16 such such JJ cord-266593-hmx2wy1p 94 17 as as IN cord-266593-hmx2wy1p 94 18 influenza influenza NN cord-266593-hmx2wy1p 94 19 , , , cord-266593-hmx2wy1p 94 20 as as IN cord-266593-hmx2wy1p 94 21 potential potential JJ cord-266593-hmx2wy1p 94 22 future future JJ cord-266593-hmx2wy1p 94 23 pandemic pandemic NN cord-266593-hmx2wy1p 94 24 influenza influenza NN cord-266593-hmx2wy1p 94 25 is be VBZ cord-266593-hmx2wy1p 94 26 of of IN cord-266593-hmx2wy1p 94 27 substantial substantial JJ cord-266593-hmx2wy1p 94 28 concern concern NN cord-266593-hmx2wy1p 94 29 globally globally RB cord-266593-hmx2wy1p 94 30 . . . cord-266593-hmx2wy1p 95 1 The the DT cord-266593-hmx2wy1p 95 2 collection collection NN cord-266593-hmx2wy1p 95 3 of of IN cord-266593-hmx2wy1p 95 4 First First NNP cord-266593-hmx2wy1p 95 5 Few few JJ cord-266593-hmx2wy1p 95 6 Hundred hundred CD cord-266593-hmx2wy1p 95 7 data datum NNS cord-266593-hmx2wy1p 95 8 is be VBZ cord-266593-hmx2wy1p 95 9 included include VBN cord-266593-hmx2wy1p 95 10 in in IN cord-266593-hmx2wy1p 95 11 the the DT cord-266593-hmx2wy1p 95 12 Australian Australian NNP cord-266593-hmx2wy1p 95 13 Health Health NNP cord-266593-hmx2wy1p 95 14 Management Management NNP cord-266593-hmx2wy1p 95 15 Plan Plan NNP cord-266593-hmx2wy1p 95 16 for for IN cord-266593-hmx2wy1p 95 17 Pandemic Pandemic NNP cord-266593-hmx2wy1p 95 18 Influenza Influenza NNP cord-266593-hmx2wy1p 95 19 ( ( -LRB- cord-266593-hmx2wy1p 95 20 AHMPPI AHMPPI NNP cord-266593-hmx2wy1p 95 21 , , , cord-266593-hmx2wy1p 95 22 2014 2014 CD cord-266593-hmx2wy1p 95 23 ) ) -RRB- cord-266593-hmx2wy1p 95 24 , , , cord-266593-hmx2wy1p 95 25 along along IN cord-266593-hmx2wy1p 95 26 with with IN cord-266593-hmx2wy1p 95 27 similar similar JJ cord-266593-hmx2wy1p 95 28 pandemic pandemic NN cord-266593-hmx2wy1p 95 29 preparedness preparedness NN cord-266593-hmx2wy1p 95 30 plans plan NNS cord-266593-hmx2wy1p 95 31 in in IN cord-266593-hmx2wy1p 95 32 other other JJ cord-266593-hmx2wy1p 95 33 jurisdictions jurisdiction NNS cord-266593-hmx2wy1p 95 34 , , , cord-266593-hmx2wy1p 95 35 so so RB cord-266593-hmx2wy1p 95 36 demonstrating demonstrate VBG cord-266593-hmx2wy1p 95 37 the the DT cord-266593-hmx2wy1p 95 38 ability ability NN cord-266593-hmx2wy1p 95 39 to to TO cord-266593-hmx2wy1p 95 40 discriminate discriminate VB cord-266593-hmx2wy1p 95 41 models model NNS cord-266593-hmx2wy1p 95 42 using use VBG cord-266593-hmx2wy1p 95 43 these these DT cord-266593-hmx2wy1p 95 44 data datum NNS cord-266593-hmx2wy1p 95 45 for for IN cord-266593-hmx2wy1p 95 46 diseases disease NNS cord-266593-hmx2wy1p 95 47 resembling resemble VBG cord-266593-hmx2wy1p 95 48 influenza influenza NN cord-266593-hmx2wy1p 95 49 is be VBZ cord-266593-hmx2wy1p 95 50 highly highly RB cord-266593-hmx2wy1p 95 51 relevant relevant JJ cord-266593-hmx2wy1p 95 52 . . . cord-266593-hmx2wy1p 96 1 As as IN cord-266593-hmx2wy1p 96 2 such such JJ cord-266593-hmx2wy1p 96 3 , , , cord-266593-hmx2wy1p 96 4 prior prior JJ cord-266593-hmx2wy1p 96 5 parameter parameter NN cord-266593-hmx2wy1p 96 6 choices choice NNS cord-266593-hmx2wy1p 96 7 and and CC cord-266593-hmx2wy1p 96 8 the the DT cord-266593-hmx2wy1p 96 9 overall overall JJ cord-266593-hmx2wy1p 96 10 duration duration NN cord-266593-hmx2wy1p 96 11 of of IN cord-266593-hmx2wy1p 96 12 the the DT cord-266593-hmx2wy1p 96 13 observation observation NN cord-266593-hmx2wy1p 96 14 process process NN cord-266593-hmx2wy1p 96 15 ( ( -LRB- cord-266593-hmx2wy1p 96 16 i.e. i.e. FW cord-266593-hmx2wy1p 96 17 , , , cord-266593-hmx2wy1p 96 18 14 14 CD cord-266593-hmx2wy1p 96 19 days day NNS cord-266593-hmx2wy1p 96 20 ) ) -RRB- cord-266593-hmx2wy1p 96 21 also also RB cord-266593-hmx2wy1p 96 22 reflect reflect VBP cord-266593-hmx2wy1p 96 23 influenza influenza NN cord-266593-hmx2wy1p 96 24 dynamics dynamic NNS cord-266593-hmx2wy1p 96 25 . . . cord-266593-hmx2wy1p 97 1 We -PRON- PRP cord-266593-hmx2wy1p 97 2 assign assign VBP cord-266593-hmx2wy1p 97 3 a a DT cord-266593-hmx2wy1p 97 4 prior prior JJ cord-266593-hmx2wy1p 97 5 distribution distribution NN cord-266593-hmx2wy1p 97 6 to to IN cord-266593-hmx2wy1p 97 7 each each DT cord-266593-hmx2wy1p 97 8 parameter parameter NN cord-266593-hmx2wy1p 97 9 ( ( -LRB- cord-266593-hmx2wy1p 97 10 Supplemental supplemental JJ cord-266593-hmx2wy1p 97 11 Figure Figure NNP cord-266593-hmx2wy1p 97 12 S1 S1 NNP cord-266593-hmx2wy1p 97 13 ) ) -RRB- cord-266593-hmx2wy1p 97 14 , , , cord-266593-hmx2wy1p 97 15 based base VBN cord-266593-hmx2wy1p 97 16 on on IN cord-266593-hmx2wy1p 97 17 physical physical JJ cord-266593-hmx2wy1p 97 18 quantities quantity NNS cord-266593-hmx2wy1p 97 19 to to TO cord-266593-hmx2wy1p 97 20 reflect reflect VB cord-266593-hmx2wy1p 97 21 the the DT cord-266593-hmx2wy1p 97 22 assumed assume VBN cord-266593-hmx2wy1p 97 23 prior prior JJ cord-266593-hmx2wy1p 97 24 knowledge knowledge NN cord-266593-hmx2wy1p 97 25 of of IN cord-266593-hmx2wy1p 97 26 the the DT cord-266593-hmx2wy1p 97 27 etiological etiological JJ cord-266593-hmx2wy1p 97 28 agent agent NN cord-266593-hmx2wy1p 97 29 : : : cord-266593-hmx2wy1p 98 1 • • NNP cord-266593-hmx2wy1p 98 2 1 1 CD cord-266593-hmx2wy1p 98 3 σ σ NNP cord-266593-hmx2wy1p 98 4 ∼ ∼ NNP cord-266593-hmx2wy1p 98 5 Gamma Gamma NNP cord-266593-hmx2wy1p 98 6 ( ( -LRB- cord-266593-hmx2wy1p 98 7 6 6 CD cord-266593-hmx2wy1p 98 8 , , , cord-266593-hmx2wy1p 98 9 1 1 CD cord-266593-hmx2wy1p 98 10 / / SYM cord-266593-hmx2wy1p 98 11 2 2 CD cord-266593-hmx2wy1p 98 12 ) ) -RRB- cord-266593-hmx2wy1p 98 13 , , , cord-266593-hmx2wy1p 98 14 representing represent VBG cord-266593-hmx2wy1p 98 15 a a DT cord-266593-hmx2wy1p 98 16 mean mean JJ cord-266593-hmx2wy1p 98 17 exposed expose VBN cord-266593-hmx2wy1p 98 18 duration duration NN cord-266593-hmx2wy1p 98 19 of of IN cord-266593-hmx2wy1p 98 20 3 3 CD cord-266593-hmx2wy1p 98 21 days day NNS cord-266593-hmx2wy1p 98 22 ( ( -LRB- cord-266593-hmx2wy1p 98 23 mode mode NN cord-266593-hmx2wy1p 98 24 at at IN cord-266593-hmx2wy1p 98 25 approximately approximately RB cord-266593-hmx2wy1p 98 26 2.5 2.5 CD cord-266593-hmx2wy1p 98 27 days day NNS cord-266593-hmx2wy1p 98 28 ) ) -RRB- cord-266593-hmx2wy1p 98 29 ; ; : cord-266593-hmx2wy1p 98 30 • • NN cord-266593-hmx2wy1p 98 31 1 1 CD cord-266593-hmx2wy1p 98 32 γ γ NN cord-266593-hmx2wy1p 98 33 ∼ ∼ NNP cord-266593-hmx2wy1p 98 34 Gamma Gamma NNP cord-266593-hmx2wy1p 98 35 ( ( -LRB- cord-266593-hmx2wy1p 98 36 6 6 CD cord-266593-hmx2wy1p 98 37 , , , cord-266593-hmx2wy1p 98 38 1 1 CD cord-266593-hmx2wy1p 98 39 / / SYM cord-266593-hmx2wy1p 98 40 2 2 CD cord-266593-hmx2wy1p 98 41 ) ) -RRB- cord-266593-hmx2wy1p 98 42 , , , cord-266593-hmx2wy1p 98 43 representing represent VBG cord-266593-hmx2wy1p 98 44 a a DT cord-266593-hmx2wy1p 98 45 mean mean JJ cord-266593-hmx2wy1p 98 46 infectious infectious JJ cord-266593-hmx2wy1p 98 47 duration duration NN cord-266593-hmx2wy1p 98 48 of of IN cord-266593-hmx2wy1p 98 49 3 3 CD cord-266593-hmx2wy1p 98 50 days day NNS cord-266593-hmx2wy1p 98 51 ( ( -LRB- cord-266593-hmx2wy1p 98 52 mode mode NN cord-266593-hmx2wy1p 98 53 at at IN cord-266593-hmx2wy1p 98 54 approximately approximately RB cord-266593-hmx2wy1p 98 55 2.5 2.5 CD cord-266593-hmx2wy1p 98 56 days day NNS cord-266593-hmx2wy1p 98 57 ) ) -RRB- cord-266593-hmx2wy1p 98 58 ; ; : cord-266593-hmx2wy1p 98 59 and and CC cord-266593-hmx2wy1p 98 60 , , , cord-266593-hmx2wy1p 98 61 representing represent VBG cord-266593-hmx2wy1p 98 62 a a DT cord-266593-hmx2wy1p 98 63 mean mean JJ cord-266593-hmx2wy1p 98 64 R r NN cord-266593-hmx2wy1p 98 65 0 0 CD cord-266593-hmx2wy1p 98 66 ( ( -LRB- cord-266593-hmx2wy1p 98 67 the the DT cord-266593-hmx2wy1p 98 68 expected expect VBN cord-266593-hmx2wy1p 98 69 number number NN cord-266593-hmx2wy1p 98 70 of of IN cord-266593-hmx2wy1p 98 71 secondary secondary JJ cord-266593-hmx2wy1p 98 72 cases case NNS cord-266593-hmx2wy1p 98 73 caused cause VBN cord-266593-hmx2wy1p 98 74 by by IN cord-266593-hmx2wy1p 98 75 an an DT cord-266593-hmx2wy1p 98 76 infectious infectious JJ cord-266593-hmx2wy1p 98 77 individual individual NN cord-266593-hmx2wy1p 98 78 in in IN cord-266593-hmx2wy1p 98 79 a a DT cord-266593-hmx2wy1p 98 80 fully fully RB cord-266593-hmx2wy1p 98 81 susceptible susceptible JJ cord-266593-hmx2wy1p 98 82 population population NN cord-266593-hmx2wy1p 98 83 ) ) -RRB- cord-266593-hmx2wy1p 98 84 of of IN cord-266593-hmx2wy1p 98 85 2 2 CD cord-266593-hmx2wy1p 98 86 ( ( -LRB- cord-266593-hmx2wy1p 98 87 mode mode NN cord-266593-hmx2wy1p 98 88 at at IN cord-266593-hmx2wy1p 98 89 approximately approximately RB cord-266593-hmx2wy1p 98 90 1.5 1.5 CD cord-266593-hmx2wy1p 98 91 ) ) -RRB- cord-266593-hmx2wy1p 98 92 . . . cord-266593-hmx2wy1p 99 1 These these DT cord-266593-hmx2wy1p 99 2 distributions distribution NNS cord-266593-hmx2wy1p 99 3 are be VBP cord-266593-hmx2wy1p 99 4 sampled sample VBN cord-266593-hmx2wy1p 99 5 per per IN cord-266593-hmx2wy1p 99 6 - - HYPH cord-266593-hmx2wy1p 99 7 simulation simulation NN cord-266593-hmx2wy1p 99 8 , , , cord-266593-hmx2wy1p 99 9 i.e. i.e. FW cord-266593-hmx2wy1p 99 10 , , , cord-266593-hmx2wy1p 99 11 sampled sample VBN cord-266593-hmx2wy1p 99 12 parameters parameter NNS cord-266593-hmx2wy1p 99 13 are be VBP cord-266593-hmx2wy1p 99 14 kept keep VBN cord-266593-hmx2wy1p 99 15 constant constant JJ cord-266593-hmx2wy1p 99 16 across across IN cord-266593-hmx2wy1p 99 17 all all DT cord-266593-hmx2wy1p 99 18 households household NNS cord-266593-hmx2wy1p 99 19 within within IN cord-266593-hmx2wy1p 99 20 a a DT cord-266593-hmx2wy1p 99 21 given give VBN cord-266593-hmx2wy1p 99 22 epidemic epidemic NN cord-266593-hmx2wy1p 99 23 . . . cord-266593-hmx2wy1p 100 1 We -PRON- PRP cord-266593-hmx2wy1p 100 2 note note VBP cord-266593-hmx2wy1p 100 3 that that IN cord-266593-hmx2wy1p 100 4 these these DT cord-266593-hmx2wy1p 100 5 priors prior NNS cord-266593-hmx2wy1p 100 6 are be VBP cord-266593-hmx2wy1p 100 7 relatively relatively RB cord-266593-hmx2wy1p 100 8 broad broad JJ cord-266593-hmx2wy1p 100 9 , , , cord-266593-hmx2wy1p 100 10 reflecting reflect VBG cord-266593-hmx2wy1p 100 11 uncertainty uncertainty NN cord-266593-hmx2wy1p 100 12 around around IN cord-266593-hmx2wy1p 100 13 disease disease NN cord-266593-hmx2wy1p 100 14 transmission transmission NN cord-266593-hmx2wy1p 100 15 dynamics dynamic NNS cord-266593-hmx2wy1p 100 16 , , , cord-266593-hmx2wy1p 100 17 but but CC cord-266593-hmx2wy1p 100 18 within within IN cord-266593-hmx2wy1p 100 19 a a DT cord-266593-hmx2wy1p 100 20 range range NN cord-266593-hmx2wy1p 100 21 resembling resemble VBG cord-266593-hmx2wy1p 100 22 the the DT cord-266593-hmx2wy1p 100 23 dynamics dynamic NNS cord-266593-hmx2wy1p 100 24 of of IN cord-266593-hmx2wy1p 100 25 a a DT cord-266593-hmx2wy1p 100 26 respiratory respiratory JJ cord-266593-hmx2wy1p 100 27 virus virus NN cord-266593-hmx2wy1p 100 28 such such JJ cord-266593-hmx2wy1p 100 29 as as IN cord-266593-hmx2wy1p 100 30 influenza influenza NN cord-266593-hmx2wy1p 100 31 . . . cord-266593-hmx2wy1p 101 1 Prior prior JJ cord-266593-hmx2wy1p 101 2 distributions distribution NNS cord-266593-hmx2wy1p 101 3 should should MD cord-266593-hmx2wy1p 101 4 be be VB cord-266593-hmx2wy1p 101 5 chosen choose VBN cord-266593-hmx2wy1p 101 6 to to TO cord-266593-hmx2wy1p 101 7 reflect reflect VB cord-266593-hmx2wy1p 101 8 what what WP cord-266593-hmx2wy1p 101 9 is be VBZ cord-266593-hmx2wy1p 101 10 known know VBN cord-266593-hmx2wy1p 101 11 about about IN cord-266593-hmx2wy1p 101 12 the the DT cord-266593-hmx2wy1p 101 13 disease disease NN cord-266593-hmx2wy1p 101 14 of of IN cord-266593-hmx2wy1p 101 15 interest interest NN cord-266593-hmx2wy1p 101 16 . . . cord-266593-hmx2wy1p 102 1 Following follow VBG cord-266593-hmx2wy1p 102 2 the the DT cord-266593-hmx2wy1p 102 3 first first JJ cord-266593-hmx2wy1p 102 4 symptomatic symptomatic JJ cord-266593-hmx2wy1p 102 5 case case NN cord-266593-hmx2wy1p 102 6 in in IN cord-266593-hmx2wy1p 102 7 a a DT cord-266593-hmx2wy1p 102 8 household household NN cord-266593-hmx2wy1p 102 9 , , , cord-266593-hmx2wy1p 102 10 the the DT cord-266593-hmx2wy1p 102 11 number number NN cord-266593-hmx2wy1p 102 12 of of IN cord-266593-hmx2wy1p 102 13 symptomatic symptomatic JJ cord-266593-hmx2wy1p 102 14 cases case NNS cord-266593-hmx2wy1p 102 15 within within IN cord-266593-hmx2wy1p 102 16 the the DT cord-266593-hmx2wy1p 102 17 household household NN cord-266593-hmx2wy1p 102 18 is be VBZ cord-266593-hmx2wy1p 102 19 observed observe VBN cord-266593-hmx2wy1p 102 20 daily daily RB cord-266593-hmx2wy1p 102 21 ( ( -LRB- cord-266593-hmx2wy1p 102 22 i.e. i.e. FW cord-266593-hmx2wy1p 102 23 , , , cord-266593-hmx2wy1p 102 24 the the DT cord-266593-hmx2wy1p 102 25 unit unit NN cord-266593-hmx2wy1p 102 26 of of IN cord-266593-hmx2wy1p 102 27 time time NN cord-266593-hmx2wy1p 102 28 considered consider VBN cord-266593-hmx2wy1p 102 29 is be VBZ cord-266593-hmx2wy1p 102 30 one one CD cord-266593-hmx2wy1p 102 31 day day NN cord-266593-hmx2wy1p 102 32 ) ) -RRB- cord-266593-hmx2wy1p 102 33 . . . cord-266593-hmx2wy1p 103 1 The the DT cord-266593-hmx2wy1p 103 2 instant instant NN cord-266593-hmx2wy1p 103 3 that that IN cord-266593-hmx2wy1p 103 4 the the DT cord-266593-hmx2wy1p 103 5 first first JJ cord-266593-hmx2wy1p 103 6 individual individual NN cord-266593-hmx2wy1p 103 7 in in IN cord-266593-hmx2wy1p 103 8 a a DT cord-266593-hmx2wy1p 103 9 household household NN cord-266593-hmx2wy1p 103 10 shows show VBZ cord-266593-hmx2wy1p 103 11 symptoms symptom NNS cord-266593-hmx2wy1p 103 12 is be VBZ cord-266593-hmx2wy1p 103 13 time time NN cord-266593-hmx2wy1p 103 14 zero zero CD cord-266593-hmx2wy1p 103 15 . . . cord-266593-hmx2wy1p 104 1 Then then RB cord-266593-hmx2wy1p 104 2 , , , cord-266593-hmx2wy1p 104 3 the the DT cord-266593-hmx2wy1p 104 4 number number NN cord-266593-hmx2wy1p 104 5 of of IN cord-266593-hmx2wy1p 104 6 cases case NNS cord-266593-hmx2wy1p 104 7 seen see VBN cord-266593-hmx2wy1p 104 8 before before IN cord-266593-hmx2wy1p 104 9 time time NN cord-266593-hmx2wy1p 104 10 1 1 CD cord-266593-hmx2wy1p 104 11 constitutes constitute VBZ cord-266593-hmx2wy1p 104 12 the the DT cord-266593-hmx2wy1p 104 13 first first JJ cord-266593-hmx2wy1p 104 14 observation observation NN cord-266593-hmx2wy1p 104 15 , , , cord-266593-hmx2wy1p 104 16 between between IN cord-266593-hmx2wy1p 104 17 time time NN cord-266593-hmx2wy1p 104 18 1 1 CD cord-266593-hmx2wy1p 104 19 and and CC cord-266593-hmx2wy1p 104 20 2 2 CD cord-266593-hmx2wy1p 104 21 the the DT cord-266593-hmx2wy1p 104 22 next next JJ cord-266593-hmx2wy1p 104 23 observation observation NN cord-266593-hmx2wy1p 104 24 , , , cord-266593-hmx2wy1p 104 25 and and CC cord-266593-hmx2wy1p 104 26 so so RB cord-266593-hmx2wy1p 104 27 on on RB cord-266593-hmx2wy1p 104 28 . . . cord-266593-hmx2wy1p 105 1 This this DT cord-266593-hmx2wy1p 105 2 proceeds proceed VBZ cord-266593-hmx2wy1p 105 3 for for IN cord-266593-hmx2wy1p 105 4 14 14 CD cord-266593-hmx2wy1p 105 5 days day NNS cord-266593-hmx2wy1p 105 6 , , , cord-266593-hmx2wy1p 105 7 with with IN cord-266593-hmx2wy1p 105 8 any any DT cord-266593-hmx2wy1p 105 9 symptoms symptom NNS cord-266593-hmx2wy1p 105 10 occurring occur VBG cord-266593-hmx2wy1p 105 11 after after IN cord-266593-hmx2wy1p 105 12 time time NN cord-266593-hmx2wy1p 105 13 14 14 CD cord-266593-hmx2wy1p 105 14 not not RB cord-266593-hmx2wy1p 105 15 observed observe VBN cord-266593-hmx2wy1p 105 16 . . . cord-266593-hmx2wy1p 106 1 The the DT cord-266593-hmx2wy1p 106 2 14 14 CD cord-266593-hmx2wy1p 106 3 day day NN cord-266593-hmx2wy1p 106 4 duration duration NN cord-266593-hmx2wy1p 106 5 allows allow VBZ cord-266593-hmx2wy1p 106 6 time time NN cord-266593-hmx2wy1p 106 7 for for IN cord-266593-hmx2wy1p 106 8 the the DT cord-266593-hmx2wy1p 106 9 index index NN cord-266593-hmx2wy1p 106 10 case case NN cord-266593-hmx2wy1p 106 11 and and CC cord-266593-hmx2wy1p 106 12 subsequent subsequent JJ cord-266593-hmx2wy1p 106 13 infections infection NNS cord-266593-hmx2wy1p 106 14 to to TO cord-266593-hmx2wy1p 106 15 likely likely JJ cord-266593-hmx2wy1p 106 16 progress progress VB cord-266593-hmx2wy1p 106 17 through through IN cord-266593-hmx2wy1p 106 18 the the DT cord-266593-hmx2wy1p 106 19 stages stage NNS cord-266593-hmx2wy1p 106 20 of of IN cord-266593-hmx2wy1p 106 21 infection infection NN cord-266593-hmx2wy1p 106 22 given give VBN cord-266593-hmx2wy1p 106 23 the the DT cord-266593-hmx2wy1p 106 24 transmission transmission NN cord-266593-hmx2wy1p 106 25 model model NN cord-266593-hmx2wy1p 106 26 and and CC cord-266593-hmx2wy1p 106 27 parameters parameter NNS cord-266593-hmx2wy1p 106 28 chosen choose VBN cord-266593-hmx2wy1p 106 29 , , , cord-266593-hmx2wy1p 106 30 resulting result VBG cord-266593-hmx2wy1p 106 31 in in IN cord-266593-hmx2wy1p 106 32 most most JJS cord-266593-hmx2wy1p 106 33 household household NN cord-266593-hmx2wy1p 106 34 transmission transmission NN cord-266593-hmx2wy1p 106 35 being be VBG cord-266593-hmx2wy1p 106 36 observed observe VBN cord-266593-hmx2wy1p 106 37 within within IN cord-266593-hmx2wy1p 106 38 this this DT cord-266593-hmx2wy1p 106 39 time time NN cord-266593-hmx2wy1p 106 40 . . . cord-266593-hmx2wy1p 107 1 If if IN cord-266593-hmx2wy1p 107 2 the the DT cord-266593-hmx2wy1p 107 3 disease disease NN cord-266593-hmx2wy1p 107 4 progressed progress VBD cord-266593-hmx2wy1p 107 5 on on IN cord-266593-hmx2wy1p 107 6 a a DT cord-266593-hmx2wy1p 107 7 different different JJ cord-266593-hmx2wy1p 107 8 timescale timescale NN cord-266593-hmx2wy1p 107 9 , , , cord-266593-hmx2wy1p 107 10 the the DT cord-266593-hmx2wy1p 107 11 duration duration NN cord-266593-hmx2wy1p 107 12 and and CC cord-266593-hmx2wy1p 107 13 frequency frequency NN cord-266593-hmx2wy1p 107 14 of of IN cord-266593-hmx2wy1p 107 15 observation observation NN cord-266593-hmx2wy1p 107 16 should should MD cord-266593-hmx2wy1p 107 17 be be VB cord-266593-hmx2wy1p 107 18 varied varied JJ cord-266593-hmx2wy1p 107 19 appropriately appropriately RB cord-266593-hmx2wy1p 107 20 , , , cord-266593-hmx2wy1p 107 21 e.g. e.g. RB cord-266593-hmx2wy1p 107 22 , , , cord-266593-hmx2wy1p 107 23 an an DT cord-266593-hmx2wy1p 107 24 infection infection NN cord-266593-hmx2wy1p 107 25 with with IN cord-266593-hmx2wy1p 107 26 slower slow JJR cord-266593-hmx2wy1p 107 27 outbreak outbreak NN cord-266593-hmx2wy1p 107 28 dynamics dynamic NNS cord-266593-hmx2wy1p 107 29 might may MD cord-266593-hmx2wy1p 107 30 be be VB cord-266593-hmx2wy1p 107 31 observed observe VBN cord-266593-hmx2wy1p 107 32 weekly weekly RB cord-266593-hmx2wy1p 107 33 rather rather RB cord-266593-hmx2wy1p 107 34 than than IN cord-266593-hmx2wy1p 107 35 daily daily RB cord-266593-hmx2wy1p 107 36 . . . cord-266593-hmx2wy1p 108 1 When when WRB cord-266593-hmx2wy1p 108 2 testing test VBG cord-266593-hmx2wy1p 108 3 the the DT cord-266593-hmx2wy1p 108 4 effect effect NN cord-266593-hmx2wy1p 108 5 of of IN cord-266593-hmx2wy1p 108 6 asymptomatic asymptomatic JJ cord-266593-hmx2wy1p 108 7 infections infection NNS cord-266593-hmx2wy1p 108 8 on on IN cord-266593-hmx2wy1p 108 9 model model NN cord-266593-hmx2wy1p 108 10 discrimination discrimination NN cord-266593-hmx2wy1p 108 11 , , , cord-266593-hmx2wy1p 108 12 we -PRON- PRP cord-266593-hmx2wy1p 108 13 sample sample VBP cord-266593-hmx2wy1p 108 14 an an DT cord-266593-hmx2wy1p 108 15 additional additional JJ cord-266593-hmx2wy1p 108 16 parameter parameter NN cord-266593-hmx2wy1p 108 17 , , , cord-266593-hmx2wy1p 108 18 p p NNP cord-266593-hmx2wy1p 108 19 obs obs NN cord-266593-hmx2wy1p 108 20 , , , cord-266593-hmx2wy1p 108 21 the the DT cord-266593-hmx2wy1p 108 22 probability probability NN cord-266593-hmx2wy1p 108 23 that that IN cord-266593-hmx2wy1p 108 24 an an DT cord-266593-hmx2wy1p 108 25 individual individual NN cord-266593-hmx2wy1p 108 26 shows show VBZ cord-266593-hmx2wy1p 108 27 symptoms symptom NNS cord-266593-hmx2wy1p 108 28 ( ( -LRB- cord-266593-hmx2wy1p 108 29 implemented implement VBN cord-266593-hmx2wy1p 108 30 as as IN cord-266593-hmx2wy1p 108 31 an an DT cord-266593-hmx2wy1p 108 32 independent independent JJ cord-266593-hmx2wy1p 108 33 Bernoulli Bernoulli NNP cord-266593-hmx2wy1p 108 34 trial trial NN cord-266593-hmx2wy1p 108 35 for for IN cord-266593-hmx2wy1p 108 36 each each DT cord-266593-hmx2wy1p 108 37 individual individual NN cord-266593-hmx2wy1p 108 38 at at IN cord-266593-hmx2wy1p 108 39 the the DT cord-266593-hmx2wy1p 108 40 time time NN cord-266593-hmx2wy1p 108 41 of of IN cord-266593-hmx2wy1p 108 42 symptom symptom NN cord-266593-hmx2wy1p 108 43 onset onset NN cord-266593-hmx2wy1p 108 44 ) ) -RRB- cord-266593-hmx2wy1p 108 45 . . . cord-266593-hmx2wy1p 109 1 Note note VB cord-266593-hmx2wy1p 109 2 that that IN cord-266593-hmx2wy1p 109 3 p p NN cord-266593-hmx2wy1p 109 4 obs obs NN cord-266593-hmx2wy1p 109 5 is be VBZ cord-266593-hmx2wy1p 109 6 held hold VBN cord-266593-hmx2wy1p 109 7 constant constant JJ cord-266593-hmx2wy1p 109 8 within within IN cord-266593-hmx2wy1p 109 9 each each DT cord-266593-hmx2wy1p 109 10 simulation simulation NN cord-266593-hmx2wy1p 109 11 , , , cord-266593-hmx2wy1p 109 12 i.e. i.e. FW cord-266593-hmx2wy1p 109 13 , , , cord-266593-hmx2wy1p 109 14 it -PRON- PRP cord-266593-hmx2wy1p 109 15 varies vary VBZ cord-266593-hmx2wy1p 109 16 by by IN cord-266593-hmx2wy1p 109 17 outbreak outbreak NN cord-266593-hmx2wy1p 109 18 , , , cord-266593-hmx2wy1p 109 19 but but CC cord-266593-hmx2wy1p 109 20 not not RB cord-266593-hmx2wy1p 109 21 by by IN cord-266593-hmx2wy1p 109 22 infected infect VBN cord-266593-hmx2wy1p 109 23 individual individual NN cord-266593-hmx2wy1p 109 24 . . . cord-266593-hmx2wy1p 110 1 We -PRON- PRP cord-266593-hmx2wy1p 110 2 explored explore VBD cord-266593-hmx2wy1p 110 3 two two CD cord-266593-hmx2wy1p 110 4 scenarios scenario NNS cord-266593-hmx2wy1p 110 5 : : : cord-266593-hmx2wy1p 110 6 ( ( -LRB- cord-266593-hmx2wy1p 110 7 1 1 LS cord-266593-hmx2wy1p 110 8 ) ) -RRB- cord-266593-hmx2wy1p 111 1 p p NNP cord-266593-hmx2wy1p 111 2 obs obs NNP cord-266593-hmx2wy1p 111 3 ~Beta(5 ~Beta(5 NNP cord-266593-hmx2wy1p 111 4 , , , cord-266593-hmx2wy1p 111 5 5 5 CD cord-266593-hmx2wy1p 111 6 ) ) -RRB- cord-266593-hmx2wy1p 111 7 ( ( -LRB- cord-266593-hmx2wy1p 111 8 i.e. i.e. FW cord-266593-hmx2wy1p 111 9 , , , cord-266593-hmx2wy1p 111 10 a a DT cord-266593-hmx2wy1p 111 11 mean mean NN cord-266593-hmx2wy1p 111 12 p p NN cord-266593-hmx2wy1p 111 13 obs obs NN cord-266593-hmx2wy1p 111 14 of of IN cord-266593-hmx2wy1p 111 15 0.5 0.5 CD cord-266593-hmx2wy1p 111 16 ) ) -RRB- cord-266593-hmx2wy1p 111 17 , , , cord-266593-hmx2wy1p 111 18 and and CC cord-266593-hmx2wy1p 111 19 ( ( -LRB- cord-266593-hmx2wy1p 111 20 2 2 LS cord-266593-hmx2wy1p 111 21 ) ) -RRB- cord-266593-hmx2wy1p 112 1 p p NNP cord-266593-hmx2wy1p 112 2 obs obs NNP cord-266593-hmx2wy1p 112 3 ~Beta(7.5 ~Beta(7.5 NNP cord-266593-hmx2wy1p 112 4 , , , cord-266593-hmx2wy1p 112 5 2.5 2.5 CD cord-266593-hmx2wy1p 112 6 ) ) -RRB- cord-266593-hmx2wy1p 112 7 ( ( -LRB- cord-266593-hmx2wy1p 112 8 i.e. i.e. FW cord-266593-hmx2wy1p 112 9 , , , cord-266593-hmx2wy1p 112 10 a a DT cord-266593-hmx2wy1p 112 11 mean mean NN cord-266593-hmx2wy1p 112 12 p p NN cord-266593-hmx2wy1p 112 13 obs obs NN cord-266593-hmx2wy1p 112 14 of of IN cord-266593-hmx2wy1p 112 15 0.75 0.75 CD cord-266593-hmx2wy1p 112 16 ) ) -RRB- cord-266593-hmx2wy1p 112 17 . . . cord-266593-hmx2wy1p 113 1 Figure figure NN cord-266593-hmx2wy1p 113 2 _SP cord-266593-hmx2wy1p 113 3 S1 S1 NNP cord-266593-hmx2wy1p 113 4 includes include VBZ cord-266593-hmx2wy1p 113 5 a a DT cord-266593-hmx2wy1p 113 6 visualisation visualisation NN cord-266593-hmx2wy1p 113 7 of of IN cord-266593-hmx2wy1p 113 8 these these DT cord-266593-hmx2wy1p 113 9 distributions distribution NNS cord-266593-hmx2wy1p 113 10 . . . cord-266593-hmx2wy1p 114 1 We -PRON- PRP cord-266593-hmx2wy1p 114 2 emphasise emphasise VBP cord-266593-hmx2wy1p 114 3 that that IN cord-266593-hmx2wy1p 114 4 in in IN cord-266593-hmx2wy1p 114 5 the the DT cord-266593-hmx2wy1p 114 6 asymptomatic asymptomatic JJ cord-266593-hmx2wy1p 114 7 infection infection NN cord-266593-hmx2wy1p 114 8 scenario scenario NN cord-266593-hmx2wy1p 114 9 , , , cord-266593-hmx2wy1p 114 10 data datum NNS cord-266593-hmx2wy1p 114 11 collection collection NN cord-266593-hmx2wy1p 114 12 from from IN cord-266593-hmx2wy1p 114 13 a a DT cord-266593-hmx2wy1p 114 14 household household NN cord-266593-hmx2wy1p 114 15 begins begin VBZ cord-266593-hmx2wy1p 114 16 with with IN cord-266593-hmx2wy1p 114 17 the the DT cord-266593-hmx2wy1p 114 18 first first JJ cord-266593-hmx2wy1p 114 19 observed observed JJ cord-266593-hmx2wy1p 114 20 symptomatic symptomatic JJ cord-266593-hmx2wy1p 114 21 case case NN cord-266593-hmx2wy1p 114 22 in in IN cord-266593-hmx2wy1p 114 23 that that DT cord-266593-hmx2wy1p 114 24 household household NN cord-266593-hmx2wy1p 114 25 ; ; : cord-266593-hmx2wy1p 114 26 the the DT cord-266593-hmx2wy1p 114 27 index index NN cord-266593-hmx2wy1p 114 28 case case NN cord-266593-hmx2wy1p 114 29 may may MD cord-266593-hmx2wy1p 114 30 be be VB cord-266593-hmx2wy1p 114 31 asymptomatic asymptomatic JJ cord-266593-hmx2wy1p 114 32 or or CC cord-266593-hmx2wy1p 114 33 symptomatic symptomatic JJ cord-266593-hmx2wy1p 114 34 . . . cord-266593-hmx2wy1p 115 1 In in IN cord-266593-hmx2wy1p 115 2 preliminary preliminary JJ cord-266593-hmx2wy1p 115 3 studies study NNS cord-266593-hmx2wy1p 115 4 ( ( -LRB- cord-266593-hmx2wy1p 115 5 not not RB cord-266593-hmx2wy1p 115 6 reported report VBN cord-266593-hmx2wy1p 115 7 ) ) -RRB- cord-266593-hmx2wy1p 115 8 we -PRON- PRP cord-266593-hmx2wy1p 115 9 estimated estimate VBD cord-266593-hmx2wy1p 115 10 the the DT cord-266593-hmx2wy1p 115 11 accuracy accuracy NN cord-266593-hmx2wy1p 115 12 of of IN cord-266593-hmx2wy1p 115 13 model model NN cord-266593-hmx2wy1p 115 14 discrimination discrimination NN cord-266593-hmx2wy1p 115 15 with with IN cord-266593-hmx2wy1p 115 16 fixed fix VBN cord-266593-hmx2wy1p 115 17 , , , cord-266593-hmx2wy1p 115 18 known know VBN cord-266593-hmx2wy1p 115 19 parametersthe parametersthe DT cord-266593-hmx2wy1p 115 20 resulting result VBG cord-266593-hmx2wy1p 115 21 accuracy accuracy NN cord-266593-hmx2wy1p 115 22 was be VBD cord-266593-hmx2wy1p 115 23 higher high JJR cord-266593-hmx2wy1p 115 24 than than IN cord-266593-hmx2wy1p 115 25 with with IN cord-266593-hmx2wy1p 115 26 parameters parameter NNS cord-266593-hmx2wy1p 115 27 sampled sample VBN cord-266593-hmx2wy1p 115 28 from from IN cord-266593-hmx2wy1p 115 29 the the DT cord-266593-hmx2wy1p 115 30 prior prior JJ cord-266593-hmx2wy1p 115 31 distribution distribution NN cord-266593-hmx2wy1p 115 32 . . . cord-266593-hmx2wy1p 116 1 However however RB cord-266593-hmx2wy1p 116 2 , , , cord-266593-hmx2wy1p 116 3 we -PRON- PRP cord-266593-hmx2wy1p 116 4 report report VBP cord-266593-hmx2wy1p 116 5 only only RB cord-266593-hmx2wy1p 116 6 the the DT cord-266593-hmx2wy1p 116 7 results result NNS cord-266593-hmx2wy1p 116 8 with with IN cord-266593-hmx2wy1p 116 9 parameters parameter NNS cord-266593-hmx2wy1p 116 10 sampled sample VBN cord-266593-hmx2wy1p 116 11 from from IN cord-266593-hmx2wy1p 116 12 a a DT cord-266593-hmx2wy1p 116 13 prior prior JJ cord-266593-hmx2wy1p 116 14 distribution distribution NN cord-266593-hmx2wy1p 116 15 here here RB cord-266593-hmx2wy1p 116 16 , , , cord-266593-hmx2wy1p 116 17 as as IN cord-266593-hmx2wy1p 116 18 in in IN cord-266593-hmx2wy1p 116 19 an an DT cord-266593-hmx2wy1p 116 20 ongoing ongoing JJ cord-266593-hmx2wy1p 116 21 outbreak outbreak NN cord-266593-hmx2wy1p 116 22 exact exact JJ cord-266593-hmx2wy1p 116 23 parameter parameter NN cord-266593-hmx2wy1p 116 24 values value NNS cord-266593-hmx2wy1p 116 25 are be VBP cord-266593-hmx2wy1p 116 26 likely likely JJ cord-266593-hmx2wy1p 116 27 to to TO cord-266593-hmx2wy1p 116 28 be be VB cord-266593-hmx2wy1p 116 29 unknown unknown JJ cord-266593-hmx2wy1p 116 30 . . . cord-266593-hmx2wy1p 117 1 To to TO cord-266593-hmx2wy1p 117 2 attempt attempt VB cord-266593-hmx2wy1p 117 3 to to TO cord-266593-hmx2wy1p 117 4 discriminate discriminate VB cord-266593-hmx2wy1p 117 5 models model NNS cord-266593-hmx2wy1p 117 6 , , , cord-266593-hmx2wy1p 117 7 we -PRON- PRP cord-266593-hmx2wy1p 117 8 use use VBP cord-266593-hmx2wy1p 117 9 the the DT cord-266593-hmx2wy1p 117 10 approximate approximate JJ cord-266593-hmx2wy1p 117 11 Bayesian Bayesian NNP cord-266593-hmx2wy1p 117 12 random random JJ cord-266593-hmx2wy1p 117 13 forest forest NN cord-266593-hmx2wy1p 117 14 approach approach NN cord-266593-hmx2wy1p 117 15 of of IN cord-266593-hmx2wy1p 117 16 Pudlo Pudlo NNP cord-266593-hmx2wy1p 117 17 et et FW cord-266593-hmx2wy1p 117 18 al al NNP cord-266593-hmx2wy1p 117 19 . . . cord-266593-hmx2wy1p 118 1 ( ( -LRB- cord-266593-hmx2wy1p 118 2 Pudlo Pudlo NNP cord-266593-hmx2wy1p 118 3 et et FW cord-266593-hmx2wy1p 118 4 al al NNP cord-266593-hmx2wy1p 118 5 . . NNP cord-266593-hmx2wy1p 118 6 , , , cord-266593-hmx2wy1p 118 7 2015 2015 CD cord-266593-hmx2wy1p 118 8 ) ) -RRB- cord-266593-hmx2wy1p 118 9 . . . cord-266593-hmx2wy1p 119 1 A a DT cord-266593-hmx2wy1p 119 2 random random JJ cord-266593-hmx2wy1p 119 3 forest forest NN cord-266593-hmx2wy1p 119 4 is be VBZ cord-266593-hmx2wy1p 119 5 a a DT cord-266593-hmx2wy1p 119 6 popular popular JJ cord-266593-hmx2wy1p 119 7 machine machine NN cord-266593-hmx2wy1p 119 8 learning learn VBG cord-266593-hmx2wy1p 119 9 classifier classifier NN cord-266593-hmx2wy1p 119 10 , , , cord-266593-hmx2wy1p 119 11 that that WDT cord-266593-hmx2wy1p 119 12 operates operate VBZ cord-266593-hmx2wy1p 119 13 by by IN cord-266593-hmx2wy1p 119 14 aggregating aggregate VBG cord-266593-hmx2wy1p 119 15 many many JJ cord-266593-hmx2wy1p 119 16 classification classification NN cord-266593-hmx2wy1p 119 17 trees tree NNS cord-266593-hmx2wy1p 119 18 , , , cord-266593-hmx2wy1p 119 19 each each DT cord-266593-hmx2wy1p 119 20 constructed construct VBN cord-266593-hmx2wy1p 119 21 on on IN cord-266593-hmx2wy1p 119 22 a a DT cord-266593-hmx2wy1p 119 23 random random JJ cord-266593-hmx2wy1p 119 24 subset subset NN cord-266593-hmx2wy1p 119 25 of of IN cord-266593-hmx2wy1p 119 26 predictors predictor NNS cord-266593-hmx2wy1p 119 27 and and CC cord-266593-hmx2wy1p 119 28 a a DT cord-266593-hmx2wy1p 119 29 bootstrap bootstrap NN cord-266593-hmx2wy1p 119 30 sample sample NN cord-266593-hmx2wy1p 119 31 of of IN cord-266593-hmx2wy1p 119 32 the the DT cord-266593-hmx2wy1p 119 33 training training NN cord-266593-hmx2wy1p 119 34 data datum NNS cord-266593-hmx2wy1p 119 35 ( ( -LRB- cord-266593-hmx2wy1p 119 36 Hastie Hastie NNP cord-266593-hmx2wy1p 119 37 et et NNP cord-266593-hmx2wy1p 119 38 al al NNP cord-266593-hmx2wy1p 119 39 . . NNP cord-266593-hmx2wy1p 119 40 , , , cord-266593-hmx2wy1p 119 41 2009 2009 CD cord-266593-hmx2wy1p 119 42 ) ) -RRB- cord-266593-hmx2wy1p 119 43 . . . cord-266593-hmx2wy1p 120 1 When when WRB cord-266593-hmx2wy1p 120 2 making make VBG cord-266593-hmx2wy1p 120 3 a a DT cord-266593-hmx2wy1p 120 4 prediction prediction NN cord-266593-hmx2wy1p 120 5 the the DT cord-266593-hmx2wy1p 120 6 classification classification NN cord-266593-hmx2wy1p 120 7 from from IN cord-266593-hmx2wy1p 120 8 each each DT cord-266593-hmx2wy1p 120 9 tree tree NN cord-266593-hmx2wy1p 120 10 is be VBZ cord-266593-hmx2wy1p 120 11 determined determine VBN cord-266593-hmx2wy1p 120 12 , , , cord-266593-hmx2wy1p 120 13 with with IN cord-266593-hmx2wy1p 120 14 the the DT cord-266593-hmx2wy1p 120 15 label label NN cord-266593-hmx2wy1p 120 16 predicted predict VBN cord-266593-hmx2wy1p 120 17 by by IN cord-266593-hmx2wy1p 120 18 the the DT cord-266593-hmx2wy1p 120 19 highest high JJS cord-266593-hmx2wy1p 120 20 number number NN cord-266593-hmx2wy1p 120 21 of of IN cord-266593-hmx2wy1p 120 22 trees tree NNS cord-266593-hmx2wy1p 120 23 being be VBG cord-266593-hmx2wy1p 120 24 the the DT cord-266593-hmx2wy1p 120 25 prediction prediction NN cord-266593-hmx2wy1p 120 26 of of IN cord-266593-hmx2wy1p 120 27 the the DT cord-266593-hmx2wy1p 120 28 random random JJ cord-266593-hmx2wy1p 120 29 forest forest NN cord-266593-hmx2wy1p 120 30 . . . cord-266593-hmx2wy1p 121 1 Implementations implementation NNS cord-266593-hmx2wy1p 121 2 of of IN cord-266593-hmx2wy1p 121 3 the the DT cord-266593-hmx2wy1p 121 4 random random JJ cord-266593-hmx2wy1p 121 5 forest forest NN cord-266593-hmx2wy1p 121 6 algorithm algorithm NN cord-266593-hmx2wy1p 121 7 are be VBP cord-266593-hmx2wy1p 121 8 available available JJ cord-266593-hmx2wy1p 121 9 in in IN cord-266593-hmx2wy1p 121 10 most most RBS cord-266593-hmx2wy1p 121 11 commonly commonly RB cord-266593-hmx2wy1p 121 12 - - HYPH cord-266593-hmx2wy1p 121 13 used use VBN cord-266593-hmx2wy1p 121 14 software software NN cord-266593-hmx2wy1p 121 15 packages package NNS cord-266593-hmx2wy1p 121 16 . . . cord-266593-hmx2wy1p 122 1 The the DT cord-266593-hmx2wy1p 122 2 process process NN cord-266593-hmx2wy1p 122 3 of of IN cord-266593-hmx2wy1p 122 4 Bayesian bayesian JJ cord-266593-hmx2wy1p 122 5 model model NN cord-266593-hmx2wy1p 122 6 discrimination discrimination NN cord-266593-hmx2wy1p 122 7 using use VBG cord-266593-hmx2wy1p 122 8 random random JJ cord-266593-hmx2wy1p 122 9 forests forest NNS cord-266593-hmx2wy1p 122 10 proceeds proceed NNS cord-266593-hmx2wy1p 122 11 as as IN cord-266593-hmx2wy1p 122 12 follows follow VBZ cord-266593-hmx2wy1p 122 13 : : : cord-266593-hmx2wy1p 122 14 • • NNP cord-266593-hmx2wy1p 123 1 Select select VB cord-266593-hmx2wy1p 123 2 a a DT cord-266593-hmx2wy1p 123 3 number number NN cord-266593-hmx2wy1p 123 4 of of IN cord-266593-hmx2wy1p 123 5 simulations simulation NNS cord-266593-hmx2wy1p 123 6 , , , cord-266593-hmx2wy1p 123 7 N N NNP cord-266593-hmx2wy1p 123 8 s s NNP cord-266593-hmx2wy1p 123 9 , , , cord-266593-hmx2wy1p 123 10 and and CC cord-266593-hmx2wy1p 123 11 a a DT cord-266593-hmx2wy1p 123 12 number number NN cord-266593-hmx2wy1p 123 13 of of IN cord-266593-hmx2wy1p 123 14 households household NNS cord-266593-hmx2wy1p 123 15 , , , cord-266593-hmx2wy1p 123 16 N N NNP cord-266593-hmx2wy1p 123 17 h h NN cord-266593-hmx2wy1p 123 18 . . . cord-266593-hmx2wy1p 124 1 • • NNP cord-266593-hmx2wy1p 125 1 For for IN cord-266593-hmx2wy1p 125 2 each each DT cord-266593-hmx2wy1p 125 3 model model NN cord-266593-hmx2wy1p 125 4 : : : cord-266593-hmx2wy1p 125 5 -Sample -Sample NNP cord-266593-hmx2wy1p 125 6 a a DT cord-266593-hmx2wy1p 125 7 set set NN cord-266593-hmx2wy1p 125 8 of of IN cord-266593-hmx2wy1p 125 9 parameters parameter NNS cord-266593-hmx2wy1p 125 10 θ θ NN cord-266593-hmx2wy1p 125 11 = = NFP cord-266593-hmx2wy1p 125 12 ( ( -LRB- cord-266593-hmx2wy1p 125 13 R R NNP cord-266593-hmx2wy1p 125 14 0 0 CD cord-266593-hmx2wy1p 125 15 , , , cord-266593-hmx2wy1p 125 16 σ σ NNP cord-266593-hmx2wy1p 125 17 , , , cord-266593-hmx2wy1p 125 18 γ γ NNP cord-266593-hmx2wy1p 125 19 ) ) -RRB- cord-266593-hmx2wy1p 125 20 from from IN cord-266593-hmx2wy1p 125 21 the the DT cord-266593-hmx2wy1p 125 22 ( ( -LRB- cord-266593-hmx2wy1p 125 23 prior prior JJ cord-266593-hmx2wy1p 125 24 ) ) -RRB- cord-266593-hmx2wy1p 125 25 distributions distribution NNS cord-266593-hmx2wy1p 125 26 . . . cord-266593-hmx2wy1p 126 1 -Simulate -simulate VB cord-266593-hmx2wy1p 127 1 N N NNP cord-266593-hmx2wy1p 127 2 h h NN cord-266593-hmx2wy1p 127 3 households household NNS cord-266593-hmx2wy1p 127 4 given give VBN cord-266593-hmx2wy1p 127 5 these these DT cord-266593-hmx2wy1p 127 6 parameters parameter NNS cord-266593-hmx2wy1p 127 7 . . . cord-266593-hmx2wy1p 128 1 -Repeat -Repeat `` cord-266593-hmx2wy1p 128 2 this this DT cord-266593-hmx2wy1p 128 3 process process NN cord-266593-hmx2wy1p 128 4 N N NNP cord-266593-hmx2wy1p 128 5 s s NNPS cord-266593-hmx2wy1p 128 6 times time NNS cord-266593-hmx2wy1p 128 7 . . . cord-266593-hmx2wy1p 129 1 • • NNP cord-266593-hmx2wy1p 130 1 Given give VBN cord-266593-hmx2wy1p 130 2 the the DT cord-266593-hmx2wy1p 130 3 N N NNP cord-266593-hmx2wy1p 130 4 s s NNP cord-266593-hmx2wy1p 130 5 simulations simulation NNS cord-266593-hmx2wy1p 130 6 from from IN cord-266593-hmx2wy1p 130 7 each each DT cord-266593-hmx2wy1p 130 8 model model NN cord-266593-hmx2wy1p 130 9 , , , cord-266593-hmx2wy1p 130 10 extract extract VB cord-266593-hmx2wy1p 130 11 the the DT cord-266593-hmx2wy1p 130 12 data datum NNS cord-266593-hmx2wy1p 130 13 corresponding correspond VBG cord-266593-hmx2wy1p 130 14 to to IN cord-266593-hmx2wy1p 130 15 the the DT cord-266593-hmx2wy1p 130 16 considered consider VBN cord-266593-hmx2wy1p 130 17 design design NN cord-266593-hmx2wy1p 130 18 . . . cord-266593-hmx2wy1p 131 1 • • NNP cord-266593-hmx2wy1p 131 2 Construct construct VB cord-266593-hmx2wy1p 131 3 a a DT cord-266593-hmx2wy1p 131 4 random random JJ cord-266593-hmx2wy1p 131 5 forest forest NN cord-266593-hmx2wy1p 131 6 that that WDT cord-266593-hmx2wy1p 131 7 predicts predict VBZ cord-266593-hmx2wy1p 131 8 the the DT cord-266593-hmx2wy1p 131 9 model model NN cord-266593-hmx2wy1p 131 10 label label NN cord-266593-hmx2wy1p 131 11 , , , cord-266593-hmx2wy1p 131 12 given give VBN cord-266593-hmx2wy1p 131 13 the the DT cord-266593-hmx2wy1p 131 14 simulations simulation NNS cord-266593-hmx2wy1p 131 15 . . . cord-266593-hmx2wy1p 132 1 • • NNP cord-266593-hmx2wy1p 132 2 Assess assess VB cord-266593-hmx2wy1p 132 3 the the DT cord-266593-hmx2wy1p 132 4 accuracy accuracy NN cord-266593-hmx2wy1p 132 5 of of IN cord-266593-hmx2wy1p 132 6 the the DT cord-266593-hmx2wy1p 132 7 process process NN cord-266593-hmx2wy1p 132 8 on on IN cord-266593-hmx2wy1p 132 9 a a DT cord-266593-hmx2wy1p 132 10 left left JJ cord-266593-hmx2wy1p 132 11 - - HYPH cord-266593-hmx2wy1p 132 12 out out RP cord-266593-hmx2wy1p 132 13 test test NN cord-266593-hmx2wy1p 132 14 set set VBN cord-266593-hmx2wy1p 132 15 . . . cord-266593-hmx2wy1p 133 1 Infections infection NNS cord-266593-hmx2wy1p 133 2 within within IN cord-266593-hmx2wy1p 133 3 each each DT cord-266593-hmx2wy1p 133 4 household household NN cord-266593-hmx2wy1p 133 5 are be VBP cord-266593-hmx2wy1p 133 6 simulated simulate VBN cord-266593-hmx2wy1p 133 7 using use VBG cord-266593-hmx2wy1p 133 8 a a DT cord-266593-hmx2wy1p 133 9 standard standard JJ cord-266593-hmx2wy1p 133 10 Doob Doob NNP cord-266593-hmx2wy1p 133 11 - - HYPH cord-266593-hmx2wy1p 133 12 Gillespie Gillespie NNP cord-266593-hmx2wy1p 133 13 algorithm algorithm NN cord-266593-hmx2wy1p 133 14 for for IN cord-266593-hmx2wy1p 133 15 simulating simulate VBG cord-266593-hmx2wy1p 133 16 continuous continuous JJ cord-266593-hmx2wy1p 133 17 - - HYPH cord-266593-hmx2wy1p 133 18 time time NN cord-266593-hmx2wy1p 133 19 Markov Markov NNP cord-266593-hmx2wy1p 133 20 chain chain NN cord-266593-hmx2wy1p 133 21 dynamics dynamic NNS cord-266593-hmx2wy1p 133 22 . . . cord-266593-hmx2wy1p 134 1 Random random JJ cord-266593-hmx2wy1p 134 2 forests forest NNS cord-266593-hmx2wy1p 134 3 were be VBD cord-266593-hmx2wy1p 134 4 constructed construct VBN cord-266593-hmx2wy1p 134 5 using use VBG cord-266593-hmx2wy1p 134 6 the the DT cord-266593-hmx2wy1p 134 7 Python Python NNP cord-266593-hmx2wy1p 134 8 scikit scikit NNS cord-266593-hmx2wy1p 134 9 - - : cord-266593-hmx2wy1p 134 10 learn learn VB cord-266593-hmx2wy1p 134 11 RandomForestClassifier randomforestclassifi JJR cord-266593-hmx2wy1p 134 12 algorithm algorithm NN cord-266593-hmx2wy1p 134 13 ( ( -LRB- cord-266593-hmx2wy1p 134 14 Pedregosa Pedregosa NNP cord-266593-hmx2wy1p 134 15 et et NNP cord-266593-hmx2wy1p 134 16 al al NNP cord-266593-hmx2wy1p 134 17 . . NNP cord-266593-hmx2wy1p 134 18 , , , cord-266593-hmx2wy1p 134 19 2011 2011 CD cord-266593-hmx2wy1p 134 20 ) ) -RRB- cord-266593-hmx2wy1p 134 21 , , , cord-266593-hmx2wy1p 134 22 with with IN cord-266593-hmx2wy1p 134 23 200 200 CD cord-266593-hmx2wy1p 134 24 trees tree NNS cord-266593-hmx2wy1p 134 25 . . . cord-266593-hmx2wy1p 135 1 Note note VB cord-266593-hmx2wy1p 135 2 that that IN cord-266593-hmx2wy1p 135 3 we -PRON- PRP cord-266593-hmx2wy1p 135 4 use use VBP cord-266593-hmx2wy1p 135 5 a a DT cord-266593-hmx2wy1p 135 6 completely completely RB cord-266593-hmx2wy1p 135 7 separate separate JJ cord-266593-hmx2wy1p 135 8 set set NN cord-266593-hmx2wy1p 135 9 of of IN cord-266593-hmx2wy1p 135 10 test test NN cord-266593-hmx2wy1p 135 11 simulations simulation NNS cord-266593-hmx2wy1p 135 12 to to TO cord-266593-hmx2wy1p 135 13 determine determine VB cord-266593-hmx2wy1p 135 14 accuracy accuracy NN cord-266593-hmx2wy1p 135 15 ( ( -LRB- cord-266593-hmx2wy1p 135 16 of of IN cord-266593-hmx2wy1p 135 17 the the DT cord-266593-hmx2wy1p 135 18 same same JJ cord-266593-hmx2wy1p 135 19 size size NN cord-266593-hmx2wy1p 135 20 as as IN cord-266593-hmx2wy1p 135 21 the the DT cord-266593-hmx2wy1p 135 22 training training NN cord-266593-hmx2wy1p 135 23 data datum NNS cord-266593-hmx2wy1p 135 24 ) ) -RRB- cord-266593-hmx2wy1p 135 25 , , , cord-266593-hmx2wy1p 135 26 rather rather RB cord-266593-hmx2wy1p 135 27 than than IN cord-266593-hmx2wy1p 135 28 out out IN cord-266593-hmx2wy1p 135 29 - - HYPH cord-266593-hmx2wy1p 135 30 of of IN cord-266593-hmx2wy1p 135 31 - - HYPH cord-266593-hmx2wy1p 135 32 bag bag NN cord-266593-hmx2wy1p 135 33 error error NN cord-266593-hmx2wy1p 135 34 . . . cord-266593-hmx2wy1p 136 1 Out out IN cord-266593-hmx2wy1p 136 2 - - HYPH cord-266593-hmx2wy1p 136 3 of of IN cord-266593-hmx2wy1p 136 4 - - HYPH cord-266593-hmx2wy1p 136 5 bag bag NN cord-266593-hmx2wy1p 136 6 error error NN cord-266593-hmx2wy1p 136 7 is be VBZ cord-266593-hmx2wy1p 136 8 an an DT cord-266593-hmx2wy1p 136 9 error error NN cord-266593-hmx2wy1p 136 10 metric metric NN cord-266593-hmx2wy1p 136 11 commonly commonly RB cord-266593-hmx2wy1p 136 12 used use VBN cord-266593-hmx2wy1p 136 13 with with IN cord-266593-hmx2wy1p 136 14 random random JJ cord-266593-hmx2wy1p 136 15 forests forest NNS cord-266593-hmx2wy1p 136 16 , , , cord-266593-hmx2wy1p 136 17 that that WDT cord-266593-hmx2wy1p 136 18 is be VBZ cord-266593-hmx2wy1p 136 19 calculated calculate VBN cord-266593-hmx2wy1p 136 20 using use VBG cord-266593-hmx2wy1p 136 21 the the DT cord-266593-hmx2wy1p 136 22 training training NN cord-266593-hmx2wy1p 136 23 data datum NNS cord-266593-hmx2wy1p 136 24 , , , cord-266593-hmx2wy1p 136 25 rather rather RB cord-266593-hmx2wy1p 136 26 than than IN cord-266593-hmx2wy1p 136 27 a a DT cord-266593-hmx2wy1p 136 28 separate separate JJ cord-266593-hmx2wy1p 136 29 test test NN cord-266593-hmx2wy1p 136 30 set set VBN cord-266593-hmx2wy1p 136 31 . . . cord-266593-hmx2wy1p 137 1 It -PRON- PRP cord-266593-hmx2wy1p 137 2 relies rely VBZ cord-266593-hmx2wy1p 137 3 on on IN cord-266593-hmx2wy1p 137 4 the the DT cord-266593-hmx2wy1p 137 5 structure structure NN cord-266593-hmx2wy1p 137 6 of of IN cord-266593-hmx2wy1p 137 7 the the DT cord-266593-hmx2wy1p 137 8 random random JJ cord-266593-hmx2wy1p 137 9 forest forest NN cord-266593-hmx2wy1p 137 10 : : : cord-266593-hmx2wy1p 137 11 in in IN cord-266593-hmx2wy1p 137 12 a a DT cord-266593-hmx2wy1p 137 13 random random JJ cord-266593-hmx2wy1p 137 14 forest forest NN cord-266593-hmx2wy1p 137 15 , , , cord-266593-hmx2wy1p 137 16 only only RB cord-266593-hmx2wy1p 137 17 a a DT cord-266593-hmx2wy1p 137 18 ( ( -LRB- cord-266593-hmx2wy1p 137 19 randomly randomly RB cord-266593-hmx2wy1p 137 20 sampled sample VBN cord-266593-hmx2wy1p 137 21 ) ) -RRB- cord-266593-hmx2wy1p 137 22 proportion proportion NN cord-266593-hmx2wy1p 137 23 of of IN cord-266593-hmx2wy1p 137 24 training training NN cord-266593-hmx2wy1p 137 25 data datum NNS cord-266593-hmx2wy1p 137 26 ( ( -LRB- cord-266593-hmx2wy1p 137 27 i.e. i.e. FW cord-266593-hmx2wy1p 137 28 , , , cord-266593-hmx2wy1p 137 29 simulations simulation NNS cord-266593-hmx2wy1p 137 30 ) ) -RRB- cord-266593-hmx2wy1p 137 31 are be VBP cord-266593-hmx2wy1p 137 32 used use VBN cord-266593-hmx2wy1p 137 33 to to TO cord-266593-hmx2wy1p 137 34 construct construct VB cord-266593-hmx2wy1p 137 35 each each DT cord-266593-hmx2wy1p 137 36 tree tree NN cord-266593-hmx2wy1p 137 37 , , , cord-266593-hmx2wy1p 137 38 so so CC cord-266593-hmx2wy1p 137 39 the the DT cord-266593-hmx2wy1p 137 40 remaining remain VBG cord-266593-hmx2wy1p 137 41 training training NN cord-266593-hmx2wy1p 137 42 data datum NNS cord-266593-hmx2wy1p 137 43 may may MD cord-266593-hmx2wy1p 137 44 be be VB cord-266593-hmx2wy1p 137 45 used use VBN cord-266593-hmx2wy1p 137 46 to to TO cord-266593-hmx2wy1p 137 47 test test VB cord-266593-hmx2wy1p 137 48 the the DT cord-266593-hmx2wy1p 137 49 accuracy accuracy NN cord-266593-hmx2wy1p 137 50 of of IN cord-266593-hmx2wy1p 137 51 that that DT cord-266593-hmx2wy1p 137 52 tree tree NN cord-266593-hmx2wy1p 137 53 . . . cord-266593-hmx2wy1p 138 1 Aggregating aggregate VBG cord-266593-hmx2wy1p 138 2 the the DT cord-266593-hmx2wy1p 138 3 result result NN cord-266593-hmx2wy1p 138 4 across across IN cord-266593-hmx2wy1p 138 5 all all DT cord-266593-hmx2wy1p 138 6 trees tree NNS cord-266593-hmx2wy1p 138 7 gives give VBZ cord-266593-hmx2wy1p 138 8 the the DT cord-266593-hmx2wy1p 138 9 out out JJ cord-266593-hmx2wy1p 138 10 - - HYPH cord-266593-hmx2wy1p 138 11 of of IN cord-266593-hmx2wy1p 138 12 - - HYPH cord-266593-hmx2wy1p 138 13 bag bag NN cord-266593-hmx2wy1p 138 14 error error NN cord-266593-hmx2wy1p 138 15 . . . cord-266593-hmx2wy1p 139 1 In in IN cord-266593-hmx2wy1p 139 2 some some DT cord-266593-hmx2wy1p 139 3 cases case NNS cord-266593-hmx2wy1p 139 4 out out IN cord-266593-hmx2wy1p 139 5 - - HYPH cord-266593-hmx2wy1p 139 6 of of IN cord-266593-hmx2wy1p 139 7 - - HYPH cord-266593-hmx2wy1p 139 8 bag bag NN cord-266593-hmx2wy1p 139 9 error error NN cord-266593-hmx2wy1p 139 10 is be VBZ cord-266593-hmx2wy1p 139 11 prone prone JJ cord-266593-hmx2wy1p 139 12 to to IN cord-266593-hmx2wy1p 139 13 bias bias NN cord-266593-hmx2wy1p 139 14 , , , cord-266593-hmx2wy1p 139 15 so so RB cord-266593-hmx2wy1p 139 16 to to TO cord-266593-hmx2wy1p 139 17 ensure ensure VB cord-266593-hmx2wy1p 139 18 we -PRON- PRP cord-266593-hmx2wy1p 139 19 are be VBP cord-266593-hmx2wy1p 139 20 correctly correctly RB cord-266593-hmx2wy1p 139 21 assessing assess VBG cord-266593-hmx2wy1p 139 22 accuracy accuracy NN cord-266593-hmx2wy1p 139 23 we -PRON- PRP cord-266593-hmx2wy1p 139 24 instead instead RB cord-266593-hmx2wy1p 139 25 use use VBP cord-266593-hmx2wy1p 139 26 a a DT cord-266593-hmx2wy1p 139 27 left left JJ cord-266593-hmx2wy1p 139 28 - - HYPH cord-266593-hmx2wy1p 139 29 out out RP cord-266593-hmx2wy1p 139 30 test test NN cord-266593-hmx2wy1p 139 31 set set VBN cord-266593-hmx2wy1p 139 32 . . . cord-266593-hmx2wy1p 140 1 We -PRON- PRP cord-266593-hmx2wy1p 140 2 report report VBP cord-266593-hmx2wy1p 140 3 accuracy accuracy NN cord-266593-hmx2wy1p 140 4 as as IN cord-266593-hmx2wy1p 140 5 the the DT cord-266593-hmx2wy1p 140 6 proportion proportion NN cord-266593-hmx2wy1p 140 7 of of IN cord-266593-hmx2wy1p 140 8 all all DT cord-266593-hmx2wy1p 140 9 test test NN cord-266593-hmx2wy1p 140 10 samples sample NNS cord-266593-hmx2wy1p 140 11 that that WDT cord-266593-hmx2wy1p 140 12 are be VBP cord-266593-hmx2wy1p 140 13 correctly correctly RB cord-266593-hmx2wy1p 140 14 assigned assign VBN cord-266593-hmx2wy1p 140 15 to to IN cord-266593-hmx2wy1p 140 16 their -PRON- PRP$ cord-266593-hmx2wy1p 140 17 generating generating NN cord-266593-hmx2wy1p 140 18 model model NN cord-266593-hmx2wy1p 140 19 . . . cord-266593-hmx2wy1p 141 1 I.e. i.e. FW cord-266593-hmx2wy1p 141 2 , , , cord-266593-hmx2wy1p 141 3 we -PRON- PRP cord-266593-hmx2wy1p 141 4 test test VBP cord-266593-hmx2wy1p 141 5 10,0 10,0 CD cord-266593-hmx2wy1p 141 6 0 0 CD cord-266593-hmx2wy1p 141 7 0 0 CD cord-266593-hmx2wy1p 141 8 left leave VBN cord-266593-hmx2wy1p 141 9 - - HYPH cord-266593-hmx2wy1p 141 10 out out RP cord-266593-hmx2wy1p 141 11 training training NN cord-266593-hmx2wy1p 141 12 simulations simulation NNS cord-266593-hmx2wy1p 141 13 from from IN cord-266593-hmx2wy1p 141 14 each each DT cord-266593-hmx2wy1p 141 15 model model NN cord-266593-hmx2wy1p 141 16 , , , cord-266593-hmx2wy1p 141 17 and and CC cord-266593-hmx2wy1p 141 18 count count VB cord-266593-hmx2wy1p 141 19 those those DT cord-266593-hmx2wy1p 141 20 assigned assign VBD cord-266593-hmx2wy1p 141 21 the the DT cord-266593-hmx2wy1p 141 22 correct correct JJ cord-266593-hmx2wy1p 141 23 label label NN cord-266593-hmx2wy1p 141 24 . . . cord-266593-hmx2wy1p 142 1 We -PRON- PRP cord-266593-hmx2wy1p 142 2 also also RB cord-266593-hmx2wy1p 142 3 count count VBP cord-266593-hmx2wy1p 142 4 the the DT cord-266593-hmx2wy1p 142 5 number number NN cord-266593-hmx2wy1p 142 6 that that WDT cord-266593-hmx2wy1p 142 7 were be VBD cord-266593-hmx2wy1p 142 8 assigned assign VBN cord-266593-hmx2wy1p 142 9 correctly correctly RB cord-266593-hmx2wy1p 142 10 to to TO cord-266593-hmx2wy1p 142 11 pre pre VB cord-266593-hmx2wy1p 142 12 - - VB cord-266593-hmx2wy1p 142 13 infectious infectious JJ cord-266593-hmx2wy1p 142 14 or or CC cord-266593-hmx2wy1p 142 15 coincident coincident JJ cord-266593-hmx2wy1p 142 16 with with IN cord-266593-hmx2wy1p 142 17 infectious infectious JJ cord-266593-hmx2wy1p 142 18 symptoms symptom NNS cord-266593-hmx2wy1p 142 19 , , , cord-266593-hmx2wy1p 142 20 versus versus IN cord-266593-hmx2wy1p 142 21 symptom symptom NN cord-266593-hmx2wy1p 142 22 onset onset NN cord-266593-hmx2wy1p 142 23 after after IN cord-266593-hmx2wy1p 142 24 infectiousness infectiousness NN cord-266593-hmx2wy1p 142 25 has have VBZ cord-266593-hmx2wy1p 142 26 begun begin VBN cord-266593-hmx2wy1p 142 27 : : : cord-266593-hmx2wy1p 142 28 we -PRON- PRP cord-266593-hmx2wy1p 142 29 call call VBP cord-266593-hmx2wy1p 142 30 this this DT cord-266593-hmx2wy1p 142 31 the the DT cord-266593-hmx2wy1p 142 32 two two CD cord-266593-hmx2wy1p 142 33 - - HYPH cord-266593-hmx2wy1p 142 34 class class NN cord-266593-hmx2wy1p 142 35 accuracy accuracy NN cord-266593-hmx2wy1p 142 36 . . . cord-266593-hmx2wy1p 143 1 This this DT cord-266593-hmx2wy1p 143 2 was be VBD cord-266593-hmx2wy1p 143 3 tested test VBN cord-266593-hmx2wy1p 143 4 as as IN cord-266593-hmx2wy1p 143 5 it -PRON- PRP cord-266593-hmx2wy1p 143 6 is be VBZ cord-266593-hmx2wy1p 143 7 the the DT cord-266593-hmx2wy1p 143 8 most most RBS cord-266593-hmx2wy1p 143 9 relevant relevant JJ cord-266593-hmx2wy1p 143 10 set set NN cord-266593-hmx2wy1p 143 11 of of IN cord-266593-hmx2wy1p 143 12 models model NNS cord-266593-hmx2wy1p 143 13 to to TO cord-266593-hmx2wy1p 143 14 discriminate discriminate VB cord-266593-hmx2wy1p 143 15 for for IN cord-266593-hmx2wy1p 143 16 determining determine VBG cord-266593-hmx2wy1p 143 17 the the DT cord-266593-hmx2wy1p 143 18 effectiveness effectiveness NN cord-266593-hmx2wy1p 143 19 of of IN cord-266593-hmx2wy1p 143 20 quarantine quarantine NN cord-266593-hmx2wy1p 143 21 for for IN cord-266593-hmx2wy1p 143 22 disease disease NN cord-266593-hmx2wy1p 143 23 control control NN cord-266593-hmx2wy1p 143 24 . . . cord-266593-hmx2wy1p 144 1 All all DT cord-266593-hmx2wy1p 144 2 code code NN cord-266593-hmx2wy1p 144 3 necessary necessary JJ cord-266593-hmx2wy1p 144 4 to to TO cord-266593-hmx2wy1p 144 5 produce produce VB cord-266593-hmx2wy1p 144 6 the the DT cord-266593-hmx2wy1p 144 7 simulated simulated JJ cord-266593-hmx2wy1p 144 8 data datum NNS cord-266593-hmx2wy1p 144 9 and and CC cord-266593-hmx2wy1p 144 10 perform perform VB cord-266593-hmx2wy1p 144 11 model model NN cord-266593-hmx2wy1p 144 12 discrimination discrimination NN cord-266593-hmx2wy1p 144 13 will will MD cord-266593-hmx2wy1p 144 14 be be VB cord-266593-hmx2wy1p 144 15 made make VBN cord-266593-hmx2wy1p 144 16 available available JJ cord-266593-hmx2wy1p 144 17 publicly publicly RB cord-266593-hmx2wy1p 144 18 ( ( -LRB- cord-266593-hmx2wy1p 144 19 upon upon IN cord-266593-hmx2wy1p 144 20 publication publication NN cord-266593-hmx2wy1p 144 21 ) ) -RRB- cord-266593-hmx2wy1p 144 22 . . . cord-266593-hmx2wy1p 145 1 To to IN cord-266593-hmx2wy1p 145 2 operationalise operationalise VB cord-266593-hmx2wy1p 145 3 this this DT cord-266593-hmx2wy1p 145 4 process process NN cord-266593-hmx2wy1p 145 5 during during IN cord-266593-hmx2wy1p 145 6 an an DT cord-266593-hmx2wy1p 145 7 outbreak outbreak NN cord-266593-hmx2wy1p 145 8 , , , cord-266593-hmx2wy1p 145 9 the the DT cord-266593-hmx2wy1p 145 10 observed observed JJ cord-266593-hmx2wy1p 145 11 household household NN cord-266593-hmx2wy1p 145 12 data datum NNS cord-266593-hmx2wy1p 145 13 ( ( -LRB- cord-266593-hmx2wy1p 145 14 on on IN cord-266593-hmx2wy1p 145 15 the the DT cord-266593-hmx2wy1p 145 16 days day NNS cord-266593-hmx2wy1p 145 17 corresponding correspond VBG cord-266593-hmx2wy1p 145 18 to to IN cord-266593-hmx2wy1p 145 19 the the DT cord-266593-hmx2wy1p 145 20 chosen choose VBN cord-266593-hmx2wy1p 145 21 design design NN cord-266593-hmx2wy1p 145 22 ) ) -RRB- cord-266593-hmx2wy1p 145 23 would would MD cord-266593-hmx2wy1p 145 24 be be VB cord-266593-hmx2wy1p 145 25 input input NN cord-266593-hmx2wy1p 145 26 into into IN cord-266593-hmx2wy1p 145 27 a a DT cord-266593-hmx2wy1p 145 28 pre pre JJ cord-266593-hmx2wy1p 145 29 - - JJ cord-266593-hmx2wy1p 145 30 trained trained JJ cord-266593-hmx2wy1p 145 31 random random JJ cord-266593-hmx2wy1p 145 32 forest forest NN cord-266593-hmx2wy1p 145 33 model model NN cord-266593-hmx2wy1p 145 34 , , , cord-266593-hmx2wy1p 145 35 which which WDT cord-266593-hmx2wy1p 145 36 would would MD cord-266593-hmx2wy1p 145 37 result result VB cord-266593-hmx2wy1p 145 38 in in IN cord-266593-hmx2wy1p 145 39 a a DT cord-266593-hmx2wy1p 145 40 predicted predict VBN cord-266593-hmx2wy1p 145 41 model model NN cord-266593-hmx2wy1p 145 42 label label NN cord-266593-hmx2wy1p 145 43 . . . cord-266593-hmx2wy1p 146 1 That that DT cord-266593-hmx2wy1p 146 2 prediction prediction NN cord-266593-hmx2wy1p 146 3 indicates indicate VBZ cord-266593-hmx2wy1p 146 4 which which WDT cord-266593-hmx2wy1p 146 5 observation observation NN cord-266593-hmx2wy1p 146 6 model model NN cord-266593-hmx2wy1p 146 7 the the DT cord-266593-hmx2wy1p 146 8 outbreak outbreak NN cord-266593-hmx2wy1p 146 9 most most RBS cord-266593-hmx2wy1p 146 10 closely closely RB cord-266593-hmx2wy1p 146 11 resembles resemble VBZ cord-266593-hmx2wy1p 146 12 . . . cord-266593-hmx2wy1p 147 1 Conducting conduct VBG cord-266593-hmx2wy1p 147 2 a a DT cord-266593-hmx2wy1p 147 3 First first JJ cord-266593-hmx2wy1p 147 4 Few few JJ cord-266593-hmx2wy1p 147 5 Hundred hundred CD cord-266593-hmx2wy1p 147 6 - - HYPH cord-266593-hmx2wy1p 147 7 style style NN cord-266593-hmx2wy1p 147 8 study study NN cord-266593-hmx2wy1p 147 9 can can MD cord-266593-hmx2wy1p 147 10 be be VB cord-266593-hmx2wy1p 147 11 extremely extremely RB cord-266593-hmx2wy1p 147 12 labour labour NN cord-266593-hmx2wy1p 147 13 intensive intensive JJ cord-266593-hmx2wy1p 147 14 . . . cord-266593-hmx2wy1p 148 1 Consequently consequently RB cord-266593-hmx2wy1p 148 2 , , , cord-266593-hmx2wy1p 148 3 we -PRON- PRP cord-266593-hmx2wy1p 148 4 wish wish VBP cord-266593-hmx2wy1p 148 5 to to TO cord-266593-hmx2wy1p 148 6 assess assess VB cord-266593-hmx2wy1p 148 7 the the DT cord-266593-hmx2wy1p 148 8 potential potential NN cord-266593-hmx2wy1p 148 9 for for IN cord-266593-hmx2wy1p 148 10 model model NN cord-266593-hmx2wy1p 148 11 discrimination discrimination NN cord-266593-hmx2wy1p 148 12 when when WRB cord-266593-hmx2wy1p 148 13 sampling sampling NN cord-266593-hmx2wy1p 148 14 is be VBZ cord-266593-hmx2wy1p 148 15 only only RB cord-266593-hmx2wy1p 148 16 performed perform VBN cord-266593-hmx2wy1p 148 17 on on IN cord-266593-hmx2wy1p 148 18 a a DT cord-266593-hmx2wy1p 148 19 subset subset NN cord-266593-hmx2wy1p 148 20 of of IN cord-266593-hmx2wy1p 148 21 days day NNS cord-266593-hmx2wy1p 148 22 , , , cord-266593-hmx2wy1p 148 23 rather rather RB cord-266593-hmx2wy1p 148 24 than than IN cord-266593-hmx2wy1p 148 25 every every DT cord-266593-hmx2wy1p 148 26 day day NN cord-266593-hmx2wy1p 148 27 . . . cord-266593-hmx2wy1p 149 1 If if IN cord-266593-hmx2wy1p 149 2 we -PRON- PRP cord-266593-hmx2wy1p 149 3 choose choose VBP cord-266593-hmx2wy1p 149 4 to to TO cord-266593-hmx2wy1p 149 5 only only RB cord-266593-hmx2wy1p 149 6 sample sample VB cord-266593-hmx2wy1p 149 7 on on IN cord-266593-hmx2wy1p 149 8 D D NNP cord-266593-hmx2wy1p 149 9 < < XX cord-266593-hmx2wy1p 149 10 14 14 CD cord-266593-hmx2wy1p 149 11 days day NNS cord-266593-hmx2wy1p 149 12 , , , cord-266593-hmx2wy1p 149 13 within within IN cord-266593-hmx2wy1p 149 14 the the DT cord-266593-hmx2wy1p 149 15 first first JJ cord-266593-hmx2wy1p 149 16 14 14 CD cord-266593-hmx2wy1p 149 17 days day NNS cord-266593-hmx2wy1p 149 18 following follow VBG cord-266593-hmx2wy1p 149 19 the the DT cord-266593-hmx2wy1p 149 20 first first JJ cord-266593-hmx2wy1p 149 21 symptomatic symptomatic JJ cord-266593-hmx2wy1p 149 22 case case NN cord-266593-hmx2wy1p 149 23 in in IN cord-266593-hmx2wy1p 149 24 each each DT cord-266593-hmx2wy1p 149 25 household household NN cord-266593-hmx2wy1p 149 26 , , , cord-266593-hmx2wy1p 149 27 we -PRON- PRP cord-266593-hmx2wy1p 149 28 must must MD cord-266593-hmx2wy1p 149 29 necessarily necessarily RB cord-266593-hmx2wy1p 149 30 also also RB cord-266593-hmx2wy1p 149 31 choose choose VB cord-266593-hmx2wy1p 149 32 the the DT cord-266593-hmx2wy1p 149 33 optimal optimal JJ cord-266593-hmx2wy1p 149 34 days day NNS cord-266593-hmx2wy1p 149 35 on on IN cord-266593-hmx2wy1p 149 36 which which WDT cord-266593-hmx2wy1p 149 37 to to TO cord-266593-hmx2wy1p 149 38 sample sample VB cord-266593-hmx2wy1p 149 39 . . . cord-266593-hmx2wy1p 150 1 We -PRON- PRP cord-266593-hmx2wy1p 150 2 call call VBP cord-266593-hmx2wy1p 150 3 the the DT cord-266593-hmx2wy1p 150 4 number number NN cord-266593-hmx2wy1p 150 5 of of IN cord-266593-hmx2wy1p 150 6 days day NNS cord-266593-hmx2wy1p 150 7 D d NN cord-266593-hmx2wy1p 150 8 being be VBG cord-266593-hmx2wy1p 150 9 sampled sample VBN cord-266593-hmx2wy1p 150 10 the the DT cord-266593-hmx2wy1p 150 11 design design NN cord-266593-hmx2wy1p 150 12 size size NN cord-266593-hmx2wy1p 150 13 . . . cord-266593-hmx2wy1p 151 1 We -PRON- PRP cord-266593-hmx2wy1p 151 2 choose choose VBP cord-266593-hmx2wy1p 151 3 those those DT cord-266593-hmx2wy1p 151 4 days day NNS cord-266593-hmx2wy1p 151 5 that that WDT cord-266593-hmx2wy1p 151 6 produce produce VBP cord-266593-hmx2wy1p 151 7 the the DT cord-266593-hmx2wy1p 151 8 highest high JJS cord-266593-hmx2wy1p 151 9 classification classification NN cord-266593-hmx2wy1p 151 10 accuracy accuracy NN cord-266593-hmx2wy1p 151 11 on on IN cord-266593-hmx2wy1p 151 12 a a DT cord-266593-hmx2wy1p 151 13 left left JJ cord-266593-hmx2wy1p 151 14 - - HYPH cord-266593-hmx2wy1p 151 15 out out RP cord-266593-hmx2wy1p 151 16 test test NN cord-266593-hmx2wy1p 151 17 set set VBN cord-266593-hmx2wy1p 151 18 . . . cord-266593-hmx2wy1p 152 1 This this DT cord-266593-hmx2wy1p 152 2 design design NN cord-266593-hmx2wy1p 152 3 problem problem NN cord-266593-hmx2wy1p 152 4 is be VBZ cord-266593-hmx2wy1p 152 5 small small JJ cord-266593-hmx2wy1p 152 6 , , , cord-266593-hmx2wy1p 152 7 with with IN cord-266593-hmx2wy1p 152 8 only only RB cord-266593-hmx2wy1p 152 9 ( ( -LRB- cord-266593-hmx2wy1p 152 10 14 14 CD cord-266593-hmx2wy1p 152 11 D d NN cord-266593-hmx2wy1p 152 12 ) ) -RRB- cord-266593-hmx2wy1p 152 13 designs design NNS cord-266593-hmx2wy1p 152 14 of of IN cord-266593-hmx2wy1p 152 15 size size NN cord-266593-hmx2wy1p 152 16 D d NN cord-266593-hmx2wy1p 152 17 ( ( -LRB- cord-266593-hmx2wy1p 152 18 or or CC cord-266593-hmx2wy1p 152 19 2 2 CD cord-266593-hmx2wy1p 152 20 14 14 CD cord-266593-hmx2wy1p 152 21 = = SYM cord-266593-hmx2wy1p 152 22 16 16 CD cord-266593-hmx2wy1p 152 23 , , , cord-266593-hmx2wy1p 152 24 384 384 CD cord-266593-hmx2wy1p 152 25 total total JJ cord-266593-hmx2wy1p 152 26 designs design NNS cord-266593-hmx2wy1p 152 27 ) ) -RRB- cord-266593-hmx2wy1p 152 28 to to TO cord-266593-hmx2wy1p 152 29 evaluate evaluate VB cord-266593-hmx2wy1p 152 30 , , , cord-266593-hmx2wy1p 152 31 so so RB cord-266593-hmx2wy1p 152 32 we -PRON- PRP cord-266593-hmx2wy1p 152 33 apply apply VBP cord-266593-hmx2wy1p 152 34 exhaustive exhaustive JJ cord-266593-hmx2wy1p 152 35 search search NN cord-266593-hmx2wy1p 152 36 in in IN cord-266593-hmx2wy1p 152 37 this this DT cord-266593-hmx2wy1p 152 38 case case NN cord-266593-hmx2wy1p 152 39 ; ; : cord-266593-hmx2wy1p 152 40 however however RB cord-266593-hmx2wy1p 152 41 a a DT cord-266593-hmx2wy1p 152 42 combinatorial combinatorial JJ cord-266593-hmx2wy1p 152 43 optimisation optimisation NN cord-266593-hmx2wy1p 152 44 algorithm algorithm NN cord-266593-hmx2wy1p 152 45 could could MD cord-266593-hmx2wy1p 152 46 be be VB cord-266593-hmx2wy1p 152 47 applied apply VBN cord-266593-hmx2wy1p 152 48 and and CC cord-266593-hmx2wy1p 152 49 would would MD cord-266593-hmx2wy1p 152 50 likely likely RB cord-266593-hmx2wy1p 152 51 be be VB cord-266593-hmx2wy1p 152 52 necessary necessary JJ cord-266593-hmx2wy1p 152 53 in in IN cord-266593-hmx2wy1p 152 54 a a DT cord-266593-hmx2wy1p 152 55 more more RBR cord-266593-hmx2wy1p 152 56 complex complex JJ cord-266593-hmx2wy1p 152 57 design design NN cord-266593-hmx2wy1p 152 58 problem problem NN cord-266593-hmx2wy1p 152 59 to to TO cord-266593-hmx2wy1p 152 60 search search VB cord-266593-hmx2wy1p 152 61 for for IN cord-266593-hmx2wy1p 152 62 the the DT cord-266593-hmx2wy1p 152 63 optimal optimal JJ cord-266593-hmx2wy1p 152 64 design design NN cord-266593-hmx2wy1p 152 65 . . . cord-266593-hmx2wy1p 153 1 Potentially potentially RB cord-266593-hmx2wy1p 153 2 symptom symptom NN cord-266593-hmx2wy1p 153 3 onset onset NN cord-266593-hmx2wy1p 153 4 data datum NNS cord-266593-hmx2wy1p 153 5 could could MD cord-266593-hmx2wy1p 153 6 be be VB cord-266593-hmx2wy1p 153 7 made make VBN cord-266593-hmx2wy1p 153 8 complete complete JJ cord-266593-hmx2wy1p 153 9 for for IN cord-266593-hmx2wy1p 153 10 this this DT cord-266593-hmx2wy1p 153 11 style style NN cord-266593-hmx2wy1p 153 12 of of IN cord-266593-hmx2wy1p 153 13 study study NN cord-266593-hmx2wy1p 153 14 by by IN cord-266593-hmx2wy1p 153 15 , , , cord-266593-hmx2wy1p 153 16 for for IN cord-266593-hmx2wy1p 153 17 example example NN cord-266593-hmx2wy1p 153 18 , , , cord-266593-hmx2wy1p 153 19 asking ask VBG cord-266593-hmx2wy1p 153 20 each each DT cord-266593-hmx2wy1p 153 21 household household NN cord-266593-hmx2wy1p 153 22 on on IN cord-266593-hmx2wy1p 153 23 which which WDT cord-266593-hmx2wy1p 153 24 day day NN cord-266593-hmx2wy1p 153 25 all all DT cord-266593-hmx2wy1p 153 26 individuals individual NNS cord-266593-hmx2wy1p 153 27 with with IN cord-266593-hmx2wy1p 153 28 symptoms symptom NNS cord-266593-hmx2wy1p 153 29 first first RB cord-266593-hmx2wy1p 153 30 presented present VBD cord-266593-hmx2wy1p 153 31 with with IN cord-266593-hmx2wy1p 153 32 them -PRON- PRP cord-266593-hmx2wy1p 153 33 ( ( -LRB- cord-266593-hmx2wy1p 153 34 rather rather RB cord-266593-hmx2wy1p 153 35 than than IN cord-266593-hmx2wy1p 153 36 just just RB cord-266593-hmx2wy1p 153 37 the the DT cord-266593-hmx2wy1p 153 38 individuals individual NNS cord-266593-hmx2wy1p 153 39 who who WP cord-266593-hmx2wy1p 153 40 presented present VBD cord-266593-hmx2wy1p 153 41 symptoms symptom NNS cord-266593-hmx2wy1p 153 42 on on IN cord-266593-hmx2wy1p 153 43 the the DT cord-266593-hmx2wy1p 153 44 sampling sampling NN cord-266593-hmx2wy1p 153 45 days day NNS cord-266593-hmx2wy1p 153 46 ) ) -RRB- cord-266593-hmx2wy1p 153 47 ; ; : cord-266593-hmx2wy1p 153 48 although although IN cord-266593-hmx2wy1p 153 49 some some DT cord-266593-hmx2wy1p 153 50 loss loss NN cord-266593-hmx2wy1p 153 51 in in IN cord-266593-hmx2wy1p 153 52 quality quality NN cord-266593-hmx2wy1p 153 53 of of IN cord-266593-hmx2wy1p 153 54 data datum NNS cord-266593-hmx2wy1p 153 55 might may MD cord-266593-hmx2wy1p 153 56 be be VB cord-266593-hmx2wy1p 153 57 expected expect VBN cord-266593-hmx2wy1p 153 58 . . . cord-266593-hmx2wy1p 154 1 In in IN cord-266593-hmx2wy1p 154 2 other other JJ cord-266593-hmx2wy1p 154 3 cases case NNS cord-266593-hmx2wy1p 154 4 it -PRON- PRP cord-266593-hmx2wy1p 154 5 might may MD cord-266593-hmx2wy1p 154 6 be be VB cord-266593-hmx2wy1p 154 7 necessary necessary JJ cord-266593-hmx2wy1p 154 8 to to TO cord-266593-hmx2wy1p 154 9 perform perform VB cord-266593-hmx2wy1p 154 10 a a DT cord-266593-hmx2wy1p 154 11 test test NN cord-266593-hmx2wy1p 154 12 ( ( -LRB- cord-266593-hmx2wy1p 154 13 e.g. e.g. RB cord-266593-hmx2wy1p 154 14 , , , cord-266593-hmx2wy1p 154 15 virological virological JJ cord-266593-hmx2wy1p 154 16 testing testing NN cord-266593-hmx2wy1p 154 17 ) ) -RRB- cord-266593-hmx2wy1p 154 18 as as IN cord-266593-hmx2wy1p 154 19 part part NN cord-266593-hmx2wy1p 154 20 of of IN cord-266593-hmx2wy1p 154 21 the the DT cord-266593-hmx2wy1p 154 22 sampling sampling NN cord-266593-hmx2wy1p 154 23 program program NN cord-266593-hmx2wy1p 154 24 , , , cord-266593-hmx2wy1p 154 25 in in IN cord-266593-hmx2wy1p 154 26 which which WDT cord-266593-hmx2wy1p 154 27 case case NN cord-266593-hmx2wy1p 154 28 choosing choose VBG cord-266593-hmx2wy1p 154 29 optimal optimal JJ cord-266593-hmx2wy1p 154 30 designs design NNS cord-266593-hmx2wy1p 154 31 that that WDT cord-266593-hmx2wy1p 154 32 are be VBP cord-266593-hmx2wy1p 154 33 as as RB cord-266593-hmx2wy1p 154 34 small small JJ cord-266593-hmx2wy1p 154 35 as as IN cord-266593-hmx2wy1p 154 36 possible possible JJ cord-266593-hmx2wy1p 154 37 can can MD cord-266593-hmx2wy1p 154 38 save save VB cord-266593-hmx2wy1p 154 39 substantial substantial JJ cord-266593-hmx2wy1p 154 40 resources resource NNS cord-266593-hmx2wy1p 154 41 . . . cord-266593-hmx2wy1p 155 1 Our -PRON- PRP$ cord-266593-hmx2wy1p 155 2 study study NN cord-266593-hmx2wy1p 155 3 provides provide VBZ cord-266593-hmx2wy1p 155 4 an an DT cord-266593-hmx2wy1p 155 5 example example NN cord-266593-hmx2wy1p 155 6 of of IN cord-266593-hmx2wy1p 155 7 the the DT cord-266593-hmx2wy1p 155 8 model model NN cord-266593-hmx2wy1p 155 9 discrimination discrimination NN cord-266593-hmx2wy1p 155 10 and and CC cord-266593-hmx2wy1p 155 11 optimal optimal JJ cord-266593-hmx2wy1p 155 12 sampling sampling NN cord-266593-hmx2wy1p 155 13 design design NN cord-266593-hmx2wy1p 155 14 process process NN cord-266593-hmx2wy1p 155 15 , , , cord-266593-hmx2wy1p 155 16 that that WDT cord-266593-hmx2wy1p 155 17 could could MD cord-266593-hmx2wy1p 155 18 be be VB cord-266593-hmx2wy1p 155 19 generalised generalise VBN cord-266593-hmx2wy1p 155 20 to to TO cord-266593-hmx2wy1p 155 21 reflect reflect VB cord-266593-hmx2wy1p 155 22 the the DT cord-266593-hmx2wy1p 155 23 appropriate appropriate JJ cord-266593-hmx2wy1p 155 24 sampling sampling NN cord-266593-hmx2wy1p 155 25 scheme scheme NN cord-266593-hmx2wy1p 155 26 where where WRB cord-266593-hmx2wy1p 155 27 necessary necessary JJ cord-266593-hmx2wy1p 155 28 . . . cord-266593-hmx2wy1p 156 1 To to TO cord-266593-hmx2wy1p 156 2 more more RBR cord-266593-hmx2wy1p 156 3 effectively effectively RB cord-266593-hmx2wy1p 156 4 use use VB cord-266593-hmx2wy1p 156 5 the the DT cord-266593-hmx2wy1p 156 6 household household NN cord-266593-hmx2wy1p 156 7 data datum NNS cord-266593-hmx2wy1p 156 8 in in IN cord-266593-hmx2wy1p 156 9 training train VBG cord-266593-hmx2wy1p 156 10 the the DT cord-266593-hmx2wy1p 156 11 random random JJ cord-266593-hmx2wy1p 156 12 forest forest NN cord-266593-hmx2wy1p 156 13 , , , cord-266593-hmx2wy1p 156 14 we -PRON- PRP cord-266593-hmx2wy1p 156 15 summarize summarize VBP cord-266593-hmx2wy1p 156 16 the the DT cord-266593-hmx2wy1p 156 17 raw raw JJ cord-266593-hmx2wy1p 156 18 household household NN cord-266593-hmx2wy1p 156 19 data datum NNS cord-266593-hmx2wy1p 156 20 to to TO cord-266593-hmx2wy1p 156 21 produce produce VB cord-266593-hmx2wy1p 156 22 daily daily JJ cord-266593-hmx2wy1p 156 23 distributions distribution NNS cord-266593-hmx2wy1p 156 24 of of IN cord-266593-hmx2wy1p 156 25 counts count NNS cord-266593-hmx2wy1p 156 26 . . . cord-266593-hmx2wy1p 157 1 That that RB cord-266593-hmx2wy1p 157 2 is is RB cord-266593-hmx2wy1p 157 3 , , , cord-266593-hmx2wy1p 157 4 we -PRON- PRP cord-266593-hmx2wy1p 157 5 count count VBP cord-266593-hmx2wy1p 157 6 the the DT cord-266593-hmx2wy1p 157 7 proportion proportion NN cord-266593-hmx2wy1p 157 8 of of IN cord-266593-hmx2wy1p 157 9 households household NNS cord-266593-hmx2wy1p 157 10 that that WDT cord-266593-hmx2wy1p 157 11 , , , cord-266593-hmx2wy1p 157 12 on on IN cord-266593-hmx2wy1p 157 13 day day NN cord-266593-hmx2wy1p 157 14 d d NNP cord-266593-hmx2wy1p 157 15 , , , cord-266593-hmx2wy1p 157 16 observed observe VBD cord-266593-hmx2wy1p 157 17 an an DT cord-266593-hmx2wy1p 157 18 incidence incidence NN cord-266593-hmx2wy1p 157 19 of of IN cord-266593-hmx2wy1p 157 20 i i PRP cord-266593-hmx2wy1p 157 21 , , , cord-266593-hmx2wy1p 157 22 and and CC cord-266593-hmx2wy1p 157 23 then then RB cord-266593-hmx2wy1p 157 24 use use VB cord-266593-hmx2wy1p 157 25 the the DT cord-266593-hmx2wy1p 157 26 resultant resultant JJ cord-266593-hmx2wy1p 157 27 ( ( -LRB- cord-266593-hmx2wy1p 157 28 design design NN cord-266593-hmx2wy1p 157 29 size size NN cord-266593-hmx2wy1p 157 30 ) ) -RRB- cord-266593-hmx2wy1p 157 31 × × NN cord-266593-hmx2wy1p 157 32 ( ( -LRB- cord-266593-hmx2wy1p 157 33 household household NN cord-266593-hmx2wy1p 157 34 size size NN cord-266593-hmx2wy1p 157 35 + + SYM cord-266593-hmx2wy1p 157 36 1 1 CD cord-266593-hmx2wy1p 157 37 ) ) -RRB- cord-266593-hmx2wy1p 157 38 data data NN cord-266593-hmx2wy1p 157 39 vector vector NN cord-266593-hmx2wy1p 157 40 as as IN cord-266593-hmx2wy1p 157 41 the the DT cord-266593-hmx2wy1p 157 42 new new JJ cord-266593-hmx2wy1p 157 43 random random JJ cord-266593-hmx2wy1p 157 44 forest forest NN cord-266593-hmx2wy1p 157 45 predictors predictor NNS cord-266593-hmx2wy1p 157 46 . . . cord-266593-hmx2wy1p 158 1 For for IN cord-266593-hmx2wy1p 158 2 example example NN cord-266593-hmx2wy1p 158 3 , , , cord-266593-hmx2wy1p 158 4 with with IN cord-266593-hmx2wy1p 158 5 designs design NNS cord-266593-hmx2wy1p 158 6 of of IN cord-266593-hmx2wy1p 158 7 size size NN cord-266593-hmx2wy1p 158 8 5 5 CD cord-266593-hmx2wy1p 158 9 , , , cord-266593-hmx2wy1p 158 10 households household NNS cord-266593-hmx2wy1p 158 11 of of IN cord-266593-hmx2wy1p 158 12 size size NN cord-266593-hmx2wy1p 158 13 5 5 CD cord-266593-hmx2wy1p 158 14 , , , cord-266593-hmx2wy1p 158 15 and and CC cord-266593-hmx2wy1p 158 16 200 200 CD cord-266593-hmx2wy1p 158 17 households household NNS cord-266593-hmx2wy1p 158 18 , , , cord-266593-hmx2wy1p 158 19 the the DT cord-266593-hmx2wy1p 158 20 raw raw JJ cord-266593-hmx2wy1p 158 21 data datum NNS cord-266593-hmx2wy1p 158 22 would would MD cord-266593-hmx2wy1p 158 23 consist consist VB cord-266593-hmx2wy1p 158 24 of of IN cord-266593-hmx2wy1p 158 25 5 5 CD cord-266593-hmx2wy1p 158 26 × × NN cord-266593-hmx2wy1p 158 27 200 200 CD cord-266593-hmx2wy1p 158 28 = = SYM cord-266593-hmx2wy1p 158 29 1000 1000 CD cord-266593-hmx2wy1p 158 30 predictors predictor NNS cord-266593-hmx2wy1p 158 31 , , , cord-266593-hmx2wy1p 158 32 whereas whereas IN cord-266593-hmx2wy1p 158 33 the the DT cord-266593-hmx2wy1p 158 34 daily daily JJ cord-266593-hmx2wy1p 158 35 summaries summary NNS cord-266593-hmx2wy1p 158 36 would would MD cord-266593-hmx2wy1p 158 37 consist consist VB cord-266593-hmx2wy1p 158 38 of of IN cord-266593-hmx2wy1p 158 39 5 5 CD cord-266593-hmx2wy1p 158 40 × × NN cord-266593-hmx2wy1p 158 41 6 6 CD cord-266593-hmx2wy1p 158 42 = = SYM cord-266593-hmx2wy1p 158 43 30 30 CD cord-266593-hmx2wy1p 158 44 predictors predictor NNS cord-266593-hmx2wy1p 158 45 . . . cord-266593-hmx2wy1p 159 1 Rather rather RB cord-266593-hmx2wy1p 159 2 than than IN cord-266593-hmx2wy1p 159 3 evaluating evaluate VBG cord-266593-hmx2wy1p 159 4 the the DT cord-266593-hmx2wy1p 159 5 full full JJ cord-266593-hmx2wy1p 159 6 set set NN cord-266593-hmx2wy1p 159 7 of of IN cord-266593-hmx2wy1p 159 8 possible possible JJ cord-266593-hmx2wy1p 159 9 designs design NNS cord-266593-hmx2wy1p 159 10 , , , cord-266593-hmx2wy1p 159 11 or or CC cord-266593-hmx2wy1p 159 12 applying apply VBG cord-266593-hmx2wy1p 159 13 an an DT cord-266593-hmx2wy1p 159 14 optimisation optimisation NN cord-266593-hmx2wy1p 159 15 algorithm algorithm NN cord-266593-hmx2wy1p 159 16 , , , cord-266593-hmx2wy1p 159 17 we -PRON- PRP cord-266593-hmx2wy1p 159 18 propose propose VBP cord-266593-hmx2wy1p 159 19 a a DT cord-266593-hmx2wy1p 159 20 heuristic heuristic NN cord-266593-hmx2wy1p 159 21 for for IN cord-266593-hmx2wy1p 159 22 efficiently efficiently RB cord-266593-hmx2wy1p 159 23 finding find VBG cord-266593-hmx2wy1p 159 24 high high JJ cord-266593-hmx2wy1p 159 25 - - HYPH cord-266593-hmx2wy1p 159 26 quality quality NN cord-266593-hmx2wy1p 159 27 designs design NNS cord-266593-hmx2wy1p 159 28 of of IN cord-266593-hmx2wy1p 159 29 a a DT cord-266593-hmx2wy1p 159 30 given give VBN cord-266593-hmx2wy1p 159 31 size size NN cord-266593-hmx2wy1p 159 32 . . . cord-266593-hmx2wy1p 160 1 This this DT cord-266593-hmx2wy1p 160 2 heuristic heuristic NN cord-266593-hmx2wy1p 160 3 is be VBZ cord-266593-hmx2wy1p 160 4 to to TO cord-266593-hmx2wy1p 160 5 perform perform VB cord-266593-hmx2wy1p 160 6 random random JJ cord-266593-hmx2wy1p 160 7 forest forest NN cord-266593-hmx2wy1p 160 8 model model NN cord-266593-hmx2wy1p 160 9 selection selection NN cord-266593-hmx2wy1p 160 10 on on IN cord-266593-hmx2wy1p 160 11 the the DT cord-266593-hmx2wy1p 160 12 largest large JJS cord-266593-hmx2wy1p 160 13 possible possible JJ cord-266593-hmx2wy1p 160 14 design design NN cord-266593-hmx2wy1p 160 15 , , , cord-266593-hmx2wy1p 160 16 extract extract VB cord-266593-hmx2wy1p 160 17 the the DT cord-266593-hmx2wy1p 160 18 random random JJ cord-266593-hmx2wy1p 160 19 forest forest NN cord-266593-hmx2wy1p 160 20 feature feature NN cord-266593-hmx2wy1p 160 21 importance importance NN cord-266593-hmx2wy1p 161 1 ( ( -LRB- cord-266593-hmx2wy1p 161 2 Fig Fig NNP cord-266593-hmx2wy1p 161 3 . . . cord-266593-hmx2wy1p 161 4 1 1 CD cord-266593-hmx2wy1p 161 5 b b NN cord-266593-hmx2wy1p 161 6 ) ) -RRB- cord-266593-hmx2wy1p 161 7 , , , cord-266593-hmx2wy1p 161 8 and and CC cord-266593-hmx2wy1p 161 9 use use VB cord-266593-hmx2wy1p 161 10 this this DT cord-266593-hmx2wy1p 161 11 random random JJ cord-266593-hmx2wy1p 161 12 forest forest NN cord-266593-hmx2wy1p 161 13 feature feature NN cord-266593-hmx2wy1p 161 14 importance importance NN cord-266593-hmx2wy1p 161 15 to to TO cord-266593-hmx2wy1p 161 16 rank rank VB cord-266593-hmx2wy1p 161 17 design design NN cord-266593-hmx2wy1p 161 18 points point NNS cord-266593-hmx2wy1p 161 19 . . . cord-266593-hmx2wy1p 162 1 Specifically specifically RB cord-266593-hmx2wy1p 162 2 , , , cord-266593-hmx2wy1p 162 3 days day NNS cord-266593-hmx2wy1p 162 4 are be VBP cord-266593-hmx2wy1p 162 5 ranked rank VBN cord-266593-hmx2wy1p 162 6 on on IN cord-266593-hmx2wy1p 162 7 their -PRON- PRP$ cord-266593-hmx2wy1p 162 8 maximum maximum JJ cord-266593-hmx2wy1p 162 9 feature feature NN cord-266593-hmx2wy1p 162 10 importance importance NN cord-266593-hmx2wy1p 162 11 ( ( -LRB- cord-266593-hmx2wy1p 162 12 i.e. i.e. FW cord-266593-hmx2wy1p 162 13 , , , cord-266593-hmx2wy1p 162 14 decrease decrease VB cord-266593-hmx2wy1p 162 15 in in IN cord-266593-hmx2wy1p 162 16 Gini Gini NNP cord-266593-hmx2wy1p 162 17 impurity impurity NN cord-266593-hmx2wy1p 162 18 , , , cord-266593-hmx2wy1p 162 19 see see VB cord-266593-hmx2wy1p 162 20 below below RB cord-266593-hmx2wy1p 162 21 ) ) -RRB- cord-266593-hmx2wy1p 162 22 ; ; : cord-266593-hmx2wy1p 162 23 the the DT cord-266593-hmx2wy1p 162 24 sum sum NN cord-266593-hmx2wy1p 162 25 of of IN cord-266593-hmx2wy1p 162 26 the the DT cord-266593-hmx2wy1p 162 27 importance importance NN cord-266593-hmx2wy1p 162 28 of of IN cord-266593-hmx2wy1p 162 29 features feature NNS cord-266593-hmx2wy1p 162 30 from from IN cord-266593-hmx2wy1p 162 31 a a DT cord-266593-hmx2wy1p 162 32 day day NN cord-266593-hmx2wy1p 162 33 was be VBD cord-266593-hmx2wy1p 162 34 also also RB cord-266593-hmx2wy1p 162 35 tested test VBN cord-266593-hmx2wy1p 162 36 , , , cord-266593-hmx2wy1p 162 37 but but CC cord-266593-hmx2wy1p 162 38 had have VBD cord-266593-hmx2wy1p 162 39 inferior inferior JJ cord-266593-hmx2wy1p 162 40 performance performance NN cord-266593-hmx2wy1p 162 41 . . . cord-266593-hmx2wy1p 163 1 A a DT cord-266593-hmx2wy1p 163 2 design design NN cord-266593-hmx2wy1p 163 3 of of IN cord-266593-hmx2wy1p 163 4 size size NN cord-266593-hmx2wy1p 163 5 d d NN cord-266593-hmx2wy1p 163 6 uses use VBZ cord-266593-hmx2wy1p 163 7 the the DT cord-266593-hmx2wy1p 163 8 highest highest RBS cord-266593-hmx2wy1p 163 9 - - HYPH cord-266593-hmx2wy1p 163 10 ranked rank VBN cord-266593-hmx2wy1p 163 11 d d NN cord-266593-hmx2wy1p 163 12 design design NN cord-266593-hmx2wy1p 163 13 points point NNS cord-266593-hmx2wy1p 163 14 . . . cord-266593-hmx2wy1p 164 1 The the DT cord-266593-hmx2wy1p 164 2 random random JJ cord-266593-hmx2wy1p 164 3 forest forest NN cord-266593-hmx2wy1p 164 4 feature feature NN cord-266593-hmx2wy1p 164 5 importance importance NN cord-266593-hmx2wy1p 164 6 metric metric JJ cord-266593-hmx2wy1p 164 7 we -PRON- PRP cord-266593-hmx2wy1p 164 8 use use VBP cord-266593-hmx2wy1p 164 9 is be VBZ cord-266593-hmx2wy1p 164 10 the the DT cord-266593-hmx2wy1p 164 11 mean mean JJ cord-266593-hmx2wy1p 164 12 decrease decrease NN cord-266593-hmx2wy1p 164 13 in in IN cord-266593-hmx2wy1p 164 14 Gini Gini NNP cord-266593-hmx2wy1p 164 15 impurity impurity NN cord-266593-hmx2wy1p 164 16 ( ( -LRB- cord-266593-hmx2wy1p 164 17 Raileanu Raileanu NNP cord-266593-hmx2wy1p 164 18 and and CC cord-266593-hmx2wy1p 164 19 Stoffel Stoffel NNP cord-266593-hmx2wy1p 164 20 , , , cord-266593-hmx2wy1p 164 21 2004 2004 CD cord-266593-hmx2wy1p 164 22 ) ) -RRB- cord-266593-hmx2wy1p 164 23 of of IN cord-266593-hmx2wy1p 164 24 a a DT cord-266593-hmx2wy1p 164 25 feature feature NN cord-266593-hmx2wy1p 164 26 across across IN cord-266593-hmx2wy1p 164 27 the the DT cord-266593-hmx2wy1p 164 28 trees tree NNS cord-266593-hmx2wy1p 164 29 in in IN cord-266593-hmx2wy1p 164 30 the the DT cord-266593-hmx2wy1p 164 31 random random JJ cord-266593-hmx2wy1p 164 32 forest forest NN cord-266593-hmx2wy1p 164 33 . . . cord-266593-hmx2wy1p 165 1 The the DT cord-266593-hmx2wy1p 165 2 Gini Gini NNP cord-266593-hmx2wy1p 165 3 impurity impurity NN cord-266593-hmx2wy1p 165 4 at at IN cord-266593-hmx2wy1p 165 5 a a DT cord-266593-hmx2wy1p 165 6 node node NN cord-266593-hmx2wy1p 165 7 is be VBZ cord-266593-hmx2wy1p 165 8 the the DT cord-266593-hmx2wy1p 165 9 probability probability NN cord-266593-hmx2wy1p 165 10 that that IN cord-266593-hmx2wy1p 165 11 a a DT cord-266593-hmx2wy1p 165 12 new new JJ cord-266593-hmx2wy1p 165 13 element element NN cord-266593-hmx2wy1p 165 14 at at IN cord-266593-hmx2wy1p 165 15 that that DT cord-266593-hmx2wy1p 165 16 node node NN cord-266593-hmx2wy1p 165 17 would would MD cord-266593-hmx2wy1p 165 18 be be VB cord-266593-hmx2wy1p 165 19 assigned assign VBN cord-266593-hmx2wy1p 165 20 an an DT cord-266593-hmx2wy1p 165 21 incorrect incorrect JJ cord-266593-hmx2wy1p 165 22 label label NN cord-266593-hmx2wy1p 165 23 , , , cord-266593-hmx2wy1p 165 24 if if IN cord-266593-hmx2wy1p 165 25 it -PRON- PRP cord-266593-hmx2wy1p 165 26 was be VBD cord-266593-hmx2wy1p 165 27 assigned assign VBN cord-266593-hmx2wy1p 165 28 a a DT cord-266593-hmx2wy1p 165 29 random random JJ cord-266593-hmx2wy1p 165 30 label label NN cord-266593-hmx2wy1p 165 31 from from IN cord-266593-hmx2wy1p 165 32 the the DT cord-266593-hmx2wy1p 165 33 distribution distribution NN cord-266593-hmx2wy1p 165 34 of of IN cord-266593-hmx2wy1p 165 35 training training NN cord-266593-hmx2wy1p 165 36 labels label NNS cord-266593-hmx2wy1p 165 37 at at IN cord-266593-hmx2wy1p 165 38 that that DT cord-266593-hmx2wy1p 165 39 node node NN cord-266593-hmx2wy1p 165 40 . . . cord-266593-hmx2wy1p 166 1 This this DT cord-266593-hmx2wy1p 166 2 metric metric NN cord-266593-hmx2wy1p 166 3 is be VBZ cord-266593-hmx2wy1p 166 4 calculated calculate VBN cord-266593-hmx2wy1p 166 5 using use VBG cord-266593-hmx2wy1p 166 6 the the DT cord-266593-hmx2wy1p 166 7 python python NNP cord-266593-hmx2wy1p 166 8 scikit scikit NNP cord-266593-hmx2wy1p 166 9 - - : cord-266593-hmx2wy1p 166 10 learn learn VB cord-266593-hmx2wy1p 166 11 random random JJ cord-266593-hmx2wy1p 166 12 forest forest NN cord-266593-hmx2wy1p 166 13 algorithm algorithm NN cord-266593-hmx2wy1p 166 14 ( ( -LRB- cord-266593-hmx2wy1p 166 15 Pedregosa Pedregosa NNP cord-266593-hmx2wy1p 166 16 et et NNP cord-266593-hmx2wy1p 166 17 al al NNP cord-266593-hmx2wy1p 166 18 . . NNP cord-266593-hmx2wy1p 166 19 , , , cord-266593-hmx2wy1p 166 20 2011 2011 CD cord-266593-hmx2wy1p 166 21 ) ) -RRB- cord-266593-hmx2wy1p 166 22 . . . cord-266593-hmx2wy1p 167 1 Random random JJ cord-266593-hmx2wy1p 167 2 forest forest NN cord-266593-hmx2wy1p 167 3 - - HYPH cord-266593-hmx2wy1p 167 4 based base VBN cord-266593-hmx2wy1p 167 5 Bayesian bayesian JJ cord-266593-hmx2wy1p 167 6 model model NN cord-266593-hmx2wy1p 167 7 discrimination discrimination NN cord-266593-hmx2wy1p 167 8 was be VBD cord-266593-hmx2wy1p 167 9 able able JJ cord-266593-hmx2wy1p 167 10 to to TO cord-266593-hmx2wy1p 167 11 discriminate discriminate VB cord-266593-hmx2wy1p 167 12 relative relative JJ cord-266593-hmx2wy1p 167 13 timing timing NN cord-266593-hmx2wy1p 167 14 of of IN cord-266593-hmx2wy1p 167 15 symptoms symptom NNS cord-266593-hmx2wy1p 167 16 and and CC cord-266593-hmx2wy1p 167 17 infectiousness infectiousness NN cord-266593-hmx2wy1p 167 18 for for IN cord-266593-hmx2wy1p 167 19 simulated simulated JJ cord-266593-hmx2wy1p 167 20 household household NN cord-266593-hmx2wy1p 167 21 - - HYPH cord-266593-hmx2wy1p 167 22 stratified stratify VBN cord-266593-hmx2wy1p 167 23 symptom symptom NN cord-266593-hmx2wy1p 167 24 - - HYPH cord-266593-hmx2wy1p 167 25 onset onset NN cord-266593-hmx2wy1p 167 26 data datum NNS cord-266593-hmx2wy1p 167 27 . . . cord-266593-hmx2wy1p 168 1 With with IN cord-266593-hmx2wy1p 168 2 200 200 CD cord-266593-hmx2wy1p 168 3 households household NNS cord-266593-hmx2wy1p 168 4 of of IN cord-266593-hmx2wy1p 168 5 size size NN cord-266593-hmx2wy1p 168 6 5 5 CD cord-266593-hmx2wy1p 168 7 , , , cord-266593-hmx2wy1p 168 8 accuracy accuracy NN cord-266593-hmx2wy1p 168 9 was be VBD cord-266593-hmx2wy1p 168 10 0.6974 0.6974 CD cord-266593-hmx2wy1p 168 11 for for IN cord-266593-hmx2wy1p 168 12 discriminating discriminate VBG cord-266593-hmx2wy1p 168 13 the the DT cord-266593-hmx2wy1p 168 14 five five CD cord-266593-hmx2wy1p 168 15 observation observation NN cord-266593-hmx2wy1p 168 16 models model NNS cord-266593-hmx2wy1p 168 17 ( ( -LRB- cord-266593-hmx2wy1p 168 18 with with IN cord-266593-hmx2wy1p 168 19 random random JJ cord-266593-hmx2wy1p 168 20 parameters parameter NNS cord-266593-hmx2wy1p 168 21 , , , cord-266593-hmx2wy1p 168 22 and and CC cord-266593-hmx2wy1p 168 23 10,0 10,0 CD cord-266593-hmx2wy1p 168 24 0 0 CD cord-266593-hmx2wy1p 168 25 0 0 CD cord-266593-hmx2wy1p 168 26 training training NN cord-266593-hmx2wy1p 168 27 simulations simulation NNS cord-266593-hmx2wy1p 168 28 per per IN cord-266593-hmx2wy1p 168 29 model model NN cord-266593-hmx2wy1p 168 30 ) ) -RRB- cord-266593-hmx2wy1p 168 31 . . . cord-266593-hmx2wy1p 169 1 When when WRB cord-266593-hmx2wy1p 169 2 selecting select VBG cord-266593-hmx2wy1p 169 3 solely solely RB cord-266593-hmx2wy1p 169 4 between between IN cord-266593-hmx2wy1p 169 5 pre pre JJ cord-266593-hmx2wy1p 169 6 - - NN cord-266593-hmx2wy1p 169 7 infectiousness infectiousness JJ cord-266593-hmx2wy1p 169 8 and and CC cord-266593-hmx2wy1p 169 9 coincident coincident JJ cord-266593-hmx2wy1p 169 10 symptoms symptom NNS cord-266593-hmx2wy1p 169 11 versus versus IN cord-266593-hmx2wy1p 169 12 postinfectiousness postinfectiousness NN cord-266593-hmx2wy1p 169 13 symptoms symptom NNS cord-266593-hmx2wy1p 169 14 , , , cord-266593-hmx2wy1p 169 15 accuracy accuracy NN cord-266593-hmx2wy1p 169 16 was be VBD cord-266593-hmx2wy1p 169 17 0.9796 0.9796 CD cord-266593-hmx2wy1p 169 18 ( ( -LRB- cord-266593-hmx2wy1p 169 19 we -PRON- PRP cord-266593-hmx2wy1p 169 20 call call VBP cord-266593-hmx2wy1p 169 21 this this DT cord-266593-hmx2wy1p 169 22 the the DT cord-266593-hmx2wy1p 169 23 two two CD cord-266593-hmx2wy1p 169 24 - - HYPH cord-266593-hmx2wy1p 169 25 class class NN cord-266593-hmx2wy1p 169 26 accuracy accuracy NN cord-266593-hmx2wy1p 169 27 ) ) -RRB- cord-266593-hmx2wy1p 169 28 ; ; : cord-266593-hmx2wy1p 169 29 suggesting suggest VBG cord-266593-hmx2wy1p 169 30 that that IN cord-266593-hmx2wy1p 169 31 most most JJS cord-266593-hmx2wy1p 169 32 model model NN cord-266593-hmx2wy1p 169 33 discrimination discrimination NN cord-266593-hmx2wy1p 169 34 error error NN cord-266593-hmx2wy1p 169 35 was be VBD cord-266593-hmx2wy1p 169 36 between between IN cord-266593-hmx2wy1p 169 37 similar similar JJ cord-266593-hmx2wy1p 169 38 models model NNS cord-266593-hmx2wy1p 169 39 to to TO cord-266593-hmx2wy1p 169 40 which which WDT cord-266593-hmx2wy1p 169 41 the the DT cord-266593-hmx2wy1p 169 42 same same JJ cord-266593-hmx2wy1p 169 43 management management NN cord-266593-hmx2wy1p 169 44 decisions decision NNS cord-266593-hmx2wy1p 169 45 might may MD cord-266593-hmx2wy1p 169 46 be be VB cord-266593-hmx2wy1p 169 47 applied apply VBN cord-266593-hmx2wy1p 169 48 . . . cord-266593-hmx2wy1p 170 1 Accuracy accuracy NN cord-266593-hmx2wy1p 170 2 was be VBD cord-266593-hmx2wy1p 170 3 reduced reduce VBN cord-266593-hmx2wy1p 170 4 with with IN cord-266593-hmx2wy1p 170 5 fewer few JJR cord-266593-hmx2wy1p 170 6 households household NNS cord-266593-hmx2wy1p 170 7 : : : cord-266593-hmx2wy1p 170 8 to to IN cord-266593-hmx2wy1p 170 9 0.608 0.608 CD cord-266593-hmx2wy1p 170 10 with with IN cord-266593-hmx2wy1p 170 11 100 100 CD cord-266593-hmx2wy1p 170 12 households household NNS cord-266593-hmx2wy1p 170 13 , , , cord-266593-hmx2wy1p 170 14 and and CC cord-266593-hmx2wy1p 170 15 0.518 0.518 CD cord-266593-hmx2wy1p 170 16 with with IN cord-266593-hmx2wy1p 170 17 only only RB cord-266593-hmx2wy1p 170 18 50 50 CD cord-266593-hmx2wy1p 170 19 households household NNS cord-266593-hmx2wy1p 170 20 ( ( -LRB- cord-266593-hmx2wy1p 170 21 Fig Fig NNP cord-266593-hmx2wy1p 170 22 . . . cord-266593-hmx2wy1p 170 23 1 1 CD cord-266593-hmx2wy1p 170 24 d d NN cord-266593-hmx2wy1p 170 25 ) ) -RRB- cord-266593-hmx2wy1p 170 26 ; ; : cord-266593-hmx2wy1p 170 27 these these DT cord-266593-hmx2wy1p 170 28 had have VBD cord-266593-hmx2wy1p 170 29 two two CD cord-266593-hmx2wy1p 170 30 - - HYPH cord-266593-hmx2wy1p 170 31 class class NN cord-266593-hmx2wy1p 170 32 accuracy accuracy NN cord-266593-hmx2wy1p 170 33 of of IN cord-266593-hmx2wy1p 170 34 0.95 0.95 CD cord-266593-hmx2wy1p 170 35 and and CC cord-266593-hmx2wy1p 170 36 0.894 0.894 CD cord-266593-hmx2wy1p 170 37 , , , cord-266593-hmx2wy1p 170 38 respectively respectively RB cord-266593-hmx2wy1p 170 39 . . . cord-266593-hmx2wy1p 171 1 These these DT cord-266593-hmx2wy1p 171 2 results result NNS cord-266593-hmx2wy1p 171 3 were be VBD cord-266593-hmx2wy1p 171 4 robust robust JJ cord-266593-hmx2wy1p 171 5 with with IN cord-266593-hmx2wy1p 171 6 respect respect NN cord-266593-hmx2wy1p 171 7 to to IN cord-266593-hmx2wy1p 171 8 variation variation NN cord-266593-hmx2wy1p 171 9 in in IN cord-266593-hmx2wy1p 171 10 household household NN cord-266593-hmx2wy1p 171 11 size size NN cord-266593-hmx2wy1p 171 12 ( ( -LRB- cord-266593-hmx2wy1p 171 13 Figure figure NN cord-266593-hmx2wy1p 171 14 S2 S2 NNP cord-266593-hmx2wy1p 171 15 ) ) -RRB- cord-266593-hmx2wy1p 171 16 , , , cord-266593-hmx2wy1p 171 17 with with IN cord-266593-hmx2wy1p 171 18 accuracy accuracy NN cord-266593-hmx2wy1p 171 19 ranging range VBG cord-266593-hmx2wy1p 171 20 from from IN cord-266593-hmx2wy1p 171 21 0.648 0.648 CD cord-266593-hmx2wy1p 171 22 with with IN cord-266593-hmx2wy1p 171 23 200 200 CD cord-266593-hmx2wy1p 171 24 households household NNS cord-266593-hmx2wy1p 171 25 of of IN cord-266593-hmx2wy1p 171 26 size size NN cord-266593-hmx2wy1p 171 27 3 3 CD cord-266593-hmx2wy1p 171 28 to to IN cord-266593-hmx2wy1p 171 29 0.703 0.703 CD cord-266593-hmx2wy1p 171 30 with with IN cord-266593-hmx2wy1p 171 31 200 200 CD cord-266593-hmx2wy1p 171 32 households household NNS cord-266593-hmx2wy1p 171 33 of of IN cord-266593-hmx2wy1p 171 34 size size NN cord-266593-hmx2wy1p 171 35 7 7 CD cord-266593-hmx2wy1p 171 36 . . . cord-266593-hmx2wy1p 172 1 We -PRON- PRP cord-266593-hmx2wy1p 172 2 report report VBP cord-266593-hmx2wy1p 172 3 results result NNS cord-266593-hmx2wy1p 172 4 for for IN cord-266593-hmx2wy1p 172 5 households household NNS cord-266593-hmx2wy1p 172 6 of of IN cord-266593-hmx2wy1p 172 7 size size NN cord-266593-hmx2wy1p 172 8 5 5 CD cord-266593-hmx2wy1p 172 9 for for IN cord-266593-hmx2wy1p 172 10 the the DT cord-266593-hmx2wy1p 172 11 remainder remainder NN cord-266593-hmx2wy1p 172 12 of of IN cord-266593-hmx2wy1p 172 13 this this DT cord-266593-hmx2wy1p 172 14 section section NN cord-266593-hmx2wy1p 172 15 . . . cord-266593-hmx2wy1p 173 1 Remarkably remarkably RB cord-266593-hmx2wy1p 173 2 , , , cord-266593-hmx2wy1p 173 3 model model NN cord-266593-hmx2wy1p 173 4 discrimination discrimination NN cord-266593-hmx2wy1p 173 5 remained remain VBD cord-266593-hmx2wy1p 173 6 accurate accurate JJ cord-266593-hmx2wy1p 173 7 when when WRB cord-266593-hmx2wy1p 173 8 only only RB cord-266593-hmx2wy1p 173 9 a a DT cord-266593-hmx2wy1p 173 10 small small JJ cord-266593-hmx2wy1p 173 11 subset subset NN cord-266593-hmx2wy1p 173 12 of of IN cord-266593-hmx2wy1p 173 13 daily daily JJ cord-266593-hmx2wy1p 173 14 household household NN cord-266593-hmx2wy1p 173 15 data datum NNS cord-266593-hmx2wy1p 173 16 were be VBD cord-266593-hmx2wy1p 173 17 observed observe VBN cord-266593-hmx2wy1p 173 18 , , , cord-266593-hmx2wy1p 173 19 when when WRB cord-266593-hmx2wy1p 173 20 the the DT cord-266593-hmx2wy1p 173 21 observations observation NNS cord-266593-hmx2wy1p 173 22 were be VBD cord-266593-hmx2wy1p 173 23 from from IN cord-266593-hmx2wy1p 173 24 an an DT cord-266593-hmx2wy1p 173 25 optimal optimal JJ cord-266593-hmx2wy1p 173 26 design design NN cord-266593-hmx2wy1p 173 27 : : : cord-266593-hmx2wy1p 173 28 a a DT cord-266593-hmx2wy1p 173 29 design design NN cord-266593-hmx2wy1p 173 30 of of IN cord-266593-hmx2wy1p 173 31 size size NN cord-266593-hmx2wy1p 173 32 5 5 CD cord-266593-hmx2wy1p 173 33 with with IN cord-266593-hmx2wy1p 173 34 200 200 CD cord-266593-hmx2wy1p 173 35 households household NNS cord-266593-hmx2wy1p 173 36 was be VBD cord-266593-hmx2wy1p 173 37 sufficient sufficient JJ cord-266593-hmx2wy1p 173 38 to to TO cord-266593-hmx2wy1p 173 39 produce produce VB cord-266593-hmx2wy1p 173 40 a a DT cord-266593-hmx2wy1p 173 41 classification classification NN cord-266593-hmx2wy1p 173 42 accuracy accuracy NN cord-266593-hmx2wy1p 173 43 of of IN cord-266593-hmx2wy1p 173 44 0.662 0.662 CD cord-266593-hmx2wy1p 173 45 and and CC cord-266593-hmx2wy1p 173 46 a a DT cord-266593-hmx2wy1p 173 47 two two CD cord-266593-hmx2wy1p 173 48 - - HYPH cord-266593-hmx2wy1p 173 49 class class NN cord-266593-hmx2wy1p 173 50 accuracy accuracy NN cord-266593-hmx2wy1p 173 51 of of IN cord-266593-hmx2wy1p 173 52 0.975 0.975 CD cord-266593-hmx2wy1p 174 1 ( ( -LRB- cord-266593-hmx2wy1p 174 2 Figs fig NNS cord-266593-hmx2wy1p 174 3 . . . cord-266593-hmx2wy1p 175 1 1 1 LS cord-266593-hmx2wy1p 175 2 d d NN cord-266593-hmx2wy1p 175 3 and and CC cord-266593-hmx2wy1p 175 4 _SP cord-266593-hmx2wy1p 175 5 2 2 CD cord-266593-hmx2wy1p 175 6 a a CD cord-266593-hmx2wy1p 175 7 ) ) -RRB- cord-266593-hmx2wy1p 175 8 , , , cord-266593-hmx2wy1p 175 9 only only RB cord-266593-hmx2wy1p 175 10 marginally marginally RB cord-266593-hmx2wy1p 175 11 below below IN cord-266593-hmx2wy1p 175 12 the the DT cord-266593-hmx2wy1p 175 13 accuracy accuracy NN cord-266593-hmx2wy1p 175 14 of of IN cord-266593-hmx2wy1p 175 15 the the DT cord-266593-hmx2wy1p 175 16 full full JJ cord-266593-hmx2wy1p 175 17 design design NN cord-266593-hmx2wy1p 175 18 ( ( -LRB- cord-266593-hmx2wy1p 175 19 Figure figure NN cord-266593-hmx2wy1p 175 20 _SP cord-266593-hmx2wy1p 175 21 S3 S3 NNP cord-266593-hmx2wy1p 175 22 ) ) -RRB- cord-266593-hmx2wy1p 175 23 . . . cord-266593-hmx2wy1p 176 1 Accuracy accuracy NN cord-266593-hmx2wy1p 176 2 increased increase VBD cord-266593-hmx2wy1p 176 3 as as IN cord-266593-hmx2wy1p 176 4 the the DT cord-266593-hmx2wy1p 176 5 design design NN cord-266593-hmx2wy1p 176 6 size size NN cord-266593-hmx2wy1p 176 7 ( ( -LRB- cord-266593-hmx2wy1p 176 8 i.e. i.e. FW cord-266593-hmx2wy1p 176 9 , , , cord-266593-hmx2wy1p 176 10 number number NN cord-266593-hmx2wy1p 176 11 of of IN cord-266593-hmx2wy1p 176 12 days day NNS cord-266593-hmx2wy1p 176 13 of of IN cord-266593-hmx2wy1p 176 14 surveillance surveillance NN cord-266593-hmx2wy1p 176 15 ) ) -RRB- cord-266593-hmx2wy1p 176 16 and and CC cord-266593-hmx2wy1p 176 17 the the DT cord-266593-hmx2wy1p 176 18 number number NN cord-266593-hmx2wy1p 176 19 of of IN cord-266593-hmx2wy1p 176 20 households household NNS cord-266593-hmx2wy1p 176 21 increased increase VBD cord-266593-hmx2wy1p 176 22 . . . cord-266593-hmx2wy1p 177 1 The the DT cord-266593-hmx2wy1p 177 2 heuristic heuristic NN cord-266593-hmx2wy1p 177 3 produced produce VBD cord-266593-hmx2wy1p 177 4 an an DT cord-266593-hmx2wy1p 177 5 effectively effectively RB cord-266593-hmx2wy1p 177 6 indistinguishable indistinguishable JJ cord-266593-hmx2wy1p 177 7 level level NN cord-266593-hmx2wy1p 177 8 of of IN cord-266593-hmx2wy1p 177 9 accuracy accuracy NN cord-266593-hmx2wy1p 177 10 compared compare VBN cord-266593-hmx2wy1p 177 11 to to IN cord-266593-hmx2wy1p 177 12 the the DT cord-266593-hmx2wy1p 177 13 optimal optimal NN cord-266593-hmx2wy1p 177 14 across across IN cord-266593-hmx2wy1p 177 15 design design NN cord-266593-hmx2wy1p 177 16 sizes size NNS cord-266593-hmx2wy1p 177 17 , , , cord-266593-hmx2wy1p 177 18 both both DT cord-266593-hmx2wy1p 177 19 for for IN cord-266593-hmx2wy1p 177 20 overall overall JJ cord-266593-hmx2wy1p 177 21 accuracy accuracy NN cord-266593-hmx2wy1p 177 22 ( ( -LRB- cord-266593-hmx2wy1p 177 23 Fig Fig NNP cord-266593-hmx2wy1p 177 24 . . . cord-266593-hmx2wy1p 177 25 1 1 CD cord-266593-hmx2wy1p 177 26 c c NN cord-266593-hmx2wy1p 177 27 ) ) -RRB- cord-266593-hmx2wy1p 177 28 and and CC cord-266593-hmx2wy1p 177 29 two two CD cord-266593-hmx2wy1p 177 30 - - HYPH cord-266593-hmx2wy1p 177 31 class class NN cord-266593-hmx2wy1p 177 32 accuracy accuracy NN cord-266593-hmx2wy1p 177 33 ( ( -LRB- cord-266593-hmx2wy1p 177 34 Fig Fig NNP cord-266593-hmx2wy1p 177 35 . . . cord-266593-hmx2wy1p 177 36 1 1 CD cord-266593-hmx2wy1p 177 37 d d NN cord-266593-hmx2wy1p 177 38 ) ) -RRB- cord-266593-hmx2wy1p 177 39 . . . cord-266593-hmx2wy1p 178 1 The the DT cord-266593-hmx2wy1p 178 2 heuristic heuristic NN cord-266593-hmx2wy1p 178 3 ensured ensure VBD cord-266593-hmx2wy1p 178 4 a a DT cord-266593-hmx2wy1p 178 5 substantial substantial JJ cord-266593-hmx2wy1p 178 6 reduction reduction NN cord-266593-hmx2wy1p 178 7 in in IN cord-266593-hmx2wy1p 178 8 computation computation NN cord-266593-hmx2wy1p 178 9 time time NN cord-266593-hmx2wy1p 178 10 : : : cord-266593-hmx2wy1p 178 11 to to TO cord-266593-hmx2wy1p 178 12 produce produce VB cord-266593-hmx2wy1p 178 13 Fig Fig NNP cord-266593-hmx2wy1p 178 14 . . . cord-266593-hmx2wy1p 178 15 1 1 CD cord-266593-hmx2wy1p 178 16 c c NN cord-266593-hmx2wy1p 178 17 , , , cord-266593-hmx2wy1p 178 18 39 39 CD cord-266593-hmx2wy1p 178 19 _SP cord-266593-hmx2wy1p 178 20 Fig Fig NNP cord-266593-hmx2wy1p 178 21 . . NNP cord-266593-hmx2wy1p 178 22 2 2 CD cord-266593-hmx2wy1p 178 23 . . . cord-266593-hmx2wy1p 179 1 ( ( -LRB- cord-266593-hmx2wy1p 179 2 a a LS cord-266593-hmx2wy1p 179 3 ) ) -RRB- cord-266593-hmx2wy1p 179 4 Accuracy accuracy NN cord-266593-hmx2wy1p 179 5 of of IN cord-266593-hmx2wy1p 179 6 model model NN cord-266593-hmx2wy1p 179 7 discrimination discrimination NN cord-266593-hmx2wy1p 179 8 in in IN cord-266593-hmx2wy1p 179 9 designs design NNS cord-266593-hmx2wy1p 179 10 of of IN cord-266593-hmx2wy1p 179 11 size size NN cord-266593-hmx2wy1p 179 12 5 5 CD cord-266593-hmx2wy1p 179 13 , , , cord-266593-hmx2wy1p 179 14 as as IN cord-266593-hmx2wy1p 179 15 the the DT cord-266593-hmx2wy1p 179 16 number number NN cord-266593-hmx2wy1p 179 17 of of IN cord-266593-hmx2wy1p 179 18 households household NNS cord-266593-hmx2wy1p 179 19 increases increase NNS cord-266593-hmx2wy1p 179 20 , , , cord-266593-hmx2wy1p 179 21 and and CC cord-266593-hmx2wy1p 179 22 under under IN cord-266593-hmx2wy1p 179 23 partial partial JJ cord-266593-hmx2wy1p 179 24 observation observation NN cord-266593-hmx2wy1p 179 25 . . . cord-266593-hmx2wy1p 180 1 Note note VB cord-266593-hmx2wy1p 180 2 that that IN cord-266593-hmx2wy1p 180 3 p p NN cord-266593-hmx2wy1p 180 4 obs obs NN cord-266593-hmx2wy1p 180 5 is be VBZ cord-266593-hmx2wy1p 180 6 not not RB cord-266593-hmx2wy1p 180 7 a a DT cord-266593-hmx2wy1p 180 8 fixed fix VBN cord-266593-hmx2wy1p 180 9 parameter parameter NN cord-266593-hmx2wy1p 180 10 but but CC cord-266593-hmx2wy1p 180 11 is be VBZ cord-266593-hmx2wy1p 180 12 sampled sample VBN cord-266593-hmx2wy1p 180 13 from from IN cord-266593-hmx2wy1p 180 14 a a DT cord-266593-hmx2wy1p 180 15 distribution distribution NN cord-266593-hmx2wy1p 180 16 : : : cord-266593-hmx2wy1p 181 1 The the DT cord-266593-hmx2wy1p 181 2 Beta(5,5 Beta(5,5 NNP cord-266593-hmx2wy1p 181 3 ) ) -RRB- cord-266593-hmx2wy1p 181 4 distribution distribution NN cord-266593-hmx2wy1p 181 5 has have VBZ cord-266593-hmx2wy1p 181 6 mean mean VB cord-266593-hmx2wy1p 181 7 0.5 0.5 CD cord-266593-hmx2wy1p 181 8 , , , cord-266593-hmx2wy1p 181 9 and and CC cord-266593-hmx2wy1p 181 10 the the DT cord-266593-hmx2wy1p 181 11 Beta(7.5,2.5 Beta(7.5,2.5 NNP cord-266593-hmx2wy1p 181 12 ) ) -RRB- cord-266593-hmx2wy1p 181 13 distribution distribution NN cord-266593-hmx2wy1p 181 14 has have VBZ cord-266593-hmx2wy1p 181 15 mean mean VB cord-266593-hmx2wy1p 181 16 0.75 0.75 CD cord-266593-hmx2wy1p 181 17 . . . cord-266593-hmx2wy1p 182 1 Figure figure NN cord-266593-hmx2wy1p 182 2 S3 S3 NNP cord-266593-hmx2wy1p 182 3 shows show VBZ cord-266593-hmx2wy1p 182 4 the the DT cord-266593-hmx2wy1p 182 5 equivalent equivalent JJ cord-266593-hmx2wy1p 182 6 result result NN cord-266593-hmx2wy1p 182 7 with with IN cord-266593-hmx2wy1p 182 8 a a DT cord-266593-hmx2wy1p 182 9 design design NN cord-266593-hmx2wy1p 182 10 of of IN cord-266593-hmx2wy1p 182 11 size size NN cord-266593-hmx2wy1p 182 12 14 14 CD cord-266593-hmx2wy1p 182 13 . . . cord-266593-hmx2wy1p 183 1 ( ( -LRB- cord-266593-hmx2wy1p 183 2 b b LS cord-266593-hmx2wy1p 183 3 ) ) -RRB- cord-266593-hmx2wy1p 183 4 Difference difference NN cord-266593-hmx2wy1p 183 5 between between IN cord-266593-hmx2wy1p 183 6 heuristic heuristic JJ cord-266593-hmx2wy1p 183 7 designs design NNS cord-266593-hmx2wy1p 183 8 ( ( -LRB- cord-266593-hmx2wy1p 183 9 coloured coloured JJ cord-266593-hmx2wy1p 183 10 points point NNS cord-266593-hmx2wy1p 183 11 ) ) -RRB- cord-266593-hmx2wy1p 183 12 and and CC cord-266593-hmx2wy1p 183 13 optimal optimal JJ cord-266593-hmx2wy1p 183 14 designs design NNS cord-266593-hmx2wy1p 183 15 ( ( -LRB- cord-266593-hmx2wy1p 183 16 black black JJ cord-266593-hmx2wy1p 183 17 boxes box NNS cord-266593-hmx2wy1p 183 18 ) ) -RRB- cord-266593-hmx2wy1p 184 1 as as IN cord-266593-hmx2wy1p 184 2 the the DT cord-266593-hmx2wy1p 184 3 design design NN cord-266593-hmx2wy1p 184 4 size size NN cord-266593-hmx2wy1p 184 5 increases increase NNS cord-266593-hmx2wy1p 184 6 . . . cord-266593-hmx2wy1p 185 1 Note note VB cord-266593-hmx2wy1p 185 2 that that IN cord-266593-hmx2wy1p 185 3 we -PRON- PRP cord-266593-hmx2wy1p 185 4 do do VBP cord-266593-hmx2wy1p 185 5 not not RB cord-266593-hmx2wy1p 185 6 evaluate evaluate VB cord-266593-hmx2wy1p 185 7 optimal optimal JJ cord-266593-hmx2wy1p 185 8 designs design NNS cord-266593-hmx2wy1p 185 9 of of IN cord-266593-hmx2wy1p 185 10 size size NN cord-266593-hmx2wy1p 185 11 1 1 CD cord-266593-hmx2wy1p 185 12 or or CC cord-266593-hmx2wy1p 185 13 2 2 CD cord-266593-hmx2wy1p 185 14 , , , cord-266593-hmx2wy1p 185 15 and and CC cord-266593-hmx2wy1p 185 16 so so RB cord-266593-hmx2wy1p 185 17 there there EX cord-266593-hmx2wy1p 185 18 are be VBP cord-266593-hmx2wy1p 185 19 no no DT cord-266593-hmx2wy1p 185 20 optimal optimal JJ cord-266593-hmx2wy1p 185 21 designs design NNS cord-266593-hmx2wy1p 185 22 in in IN cord-266593-hmx2wy1p 185 23 these these DT cord-266593-hmx2wy1p 185 24 columns column NNS cord-266593-hmx2wy1p 185 25 . . . cord-266593-hmx2wy1p 186 1 ( ( -LRB- cord-266593-hmx2wy1p 186 2 c c NN cord-266593-hmx2wy1p 186 3 ) ) -RRB- cord-266593-hmx2wy1p 186 4 Distribution distribution NN cord-266593-hmx2wy1p 186 5 of of IN cord-266593-hmx2wy1p 186 6 training training NN cord-266593-hmx2wy1p 186 7 sample sample NN cord-266593-hmx2wy1p 186 8 observations observation NNS cord-266593-hmx2wy1p 186 9 ( ( -LRB- cord-266593-hmx2wy1p 186 10 under under IN cord-266593-hmx2wy1p 186 11 each each DT cord-266593-hmx2wy1p 186 12 model model NN cord-266593-hmx2wy1p 186 13 and and CC cord-266593-hmx2wy1p 186 14 number number NN cord-266593-hmx2wy1p 186 15 of of IN cord-266593-hmx2wy1p 186 16 households household NNS cord-266593-hmx2wy1p 186 17 ) ) -RRB- cord-266593-hmx2wy1p 186 18 for for IN cord-266593-hmx2wy1p 186 19 the the DT cord-266593-hmx2wy1p 186 20 most most RBS cord-266593-hmx2wy1p 186 21 important important JJ cord-266593-hmx2wy1p 186 22 feature feature NN cord-266593-hmx2wy1p 186 23 under under IN cord-266593-hmx2wy1p 186 24 the the DT cord-266593-hmx2wy1p 186 25 heuristic heuristic NN cord-266593-hmx2wy1p 186 26 : : : cord-266593-hmx2wy1p 186 27 the the DT cord-266593-hmx2wy1p 186 28 proportion proportion NN cord-266593-hmx2wy1p 186 29 of of IN cord-266593-hmx2wy1p 186 30 households household NNS cord-266593-hmx2wy1p 186 31 with with IN cord-266593-hmx2wy1p 186 32 1 1 CD cord-266593-hmx2wy1p 186 33 case case NN cord-266593-hmx2wy1p 186 34 observed observe VBN cord-266593-hmx2wy1p 186 35 on on IN cord-266593-hmx2wy1p 186 36 day day NN cord-266593-hmx2wy1p 186 37 2 2 CD cord-266593-hmx2wy1p 186 38 . . . cord-266593-hmx2wy1p 187 1 Each each DT cord-266593-hmx2wy1p 187 2 coloured coloured JJ cord-266593-hmx2wy1p 187 3 point point NN cord-266593-hmx2wy1p 187 4 represents represent VBZ cord-266593-hmx2wy1p 187 5 an an DT cord-266593-hmx2wy1p 187 6 observation observation NN cord-266593-hmx2wy1p 187 7 in in IN cord-266593-hmx2wy1p 187 8 the the DT cord-266593-hmx2wy1p 187 9 training training NN cord-266593-hmx2wy1p 187 10 sample sample NN cord-266593-hmx2wy1p 187 11 . . . cord-266593-hmx2wy1p 188 1 These these DT cord-266593-hmx2wy1p 188 2 results result NNS cord-266593-hmx2wy1p 188 3 correspond correspond VBP cord-266593-hmx2wy1p 188 4 to to IN cord-266593-hmx2wy1p 188 5 households household NNS cord-266593-hmx2wy1p 188 6 of of IN cord-266593-hmx2wy1p 188 7 size size NN cord-266593-hmx2wy1p 188 8 5 5 CD cord-266593-hmx2wy1p 188 9 , , , cord-266593-hmx2wy1p 188 10 with with IN cord-266593-hmx2wy1p 188 11 10,0 10,0 CD cord-266593-hmx2wy1p 188 12 0 0 CD cord-266593-hmx2wy1p 188 13 0 0 CD cord-266593-hmx2wy1p 188 14 training training NN cord-266593-hmx2wy1p 188 15 samples sample NNS cord-266593-hmx2wy1p 188 16 from from IN cord-266593-hmx2wy1p 188 17 each each DT cord-266593-hmx2wy1p 188 18 model model NN cord-266593-hmx2wy1p 188 19 , , , cord-266593-hmx2wy1p 188 20 each each DT cord-266593-hmx2wy1p 188 21 with with IN cord-266593-hmx2wy1p 188 22 parameters parameter NNS cord-266593-hmx2wy1p 188 23 drawn draw VBN cord-266593-hmx2wy1p 188 24 from from IN cord-266593-hmx2wy1p 188 25 the the DT cord-266593-hmx2wy1p 188 26 distributions distribution NNS cord-266593-hmx2wy1p 188 27 that that WDT cord-266593-hmx2wy1p 188 28 appear appear VBP cord-266593-hmx2wy1p 188 29 in in IN cord-266593-hmx2wy1p 188 30 Supplemental supplemental JJ cord-266593-hmx2wy1p 188 31 Figure Figure NNP cord-266593-hmx2wy1p 188 32 S1 s1 NN cord-266593-hmx2wy1p 188 33 . . . cord-266593-hmx2wy1p 189 1 random random JJ cord-266593-hmx2wy1p 189 2 forests forest NNS cord-266593-hmx2wy1p 189 3 were be VBD cord-266593-hmx2wy1p 189 4 required require VBN cord-266593-hmx2wy1p 189 5 when when WRB cord-266593-hmx2wy1p 189 6 using use VBG cord-266593-hmx2wy1p 189 7 the the DT cord-266593-hmx2wy1p 189 8 heuristic heuristic NN cord-266593-hmx2wy1p 189 9 , , , cord-266593-hmx2wy1p 189 10 compared compare VBN cord-266593-hmx2wy1p 189 11 to to IN cord-266593-hmx2wy1p 189 12 49,107 49,107 CD cord-266593-hmx2wy1p 189 13 random random JJ cord-266593-hmx2wy1p 189 14 forests forest NNS cord-266593-hmx2wy1p 189 15 to to TO cord-266593-hmx2wy1p 189 16 produce produce VB cord-266593-hmx2wy1p 189 17 the the DT cord-266593-hmx2wy1p 189 18 optimal optimal JJ cord-266593-hmx2wy1p 189 19 results result NNS cord-266593-hmx2wy1p 189 20 . . . cord-266593-hmx2wy1p 190 1 The the DT cord-266593-hmx2wy1p 190 2 key key JJ cord-266593-hmx2wy1p 190 3 design design NN cord-266593-hmx2wy1p 190 4 points point NNS cord-266593-hmx2wy1p 190 5 ( ( -LRB- cord-266593-hmx2wy1p 190 6 i.e. i.e. FW cord-266593-hmx2wy1p 190 7 , , , cord-266593-hmx2wy1p 190 8 sampling sampling NN cord-266593-hmx2wy1p 190 9 days day NNS cord-266593-hmx2wy1p 190 10 ) ) -RRB- cord-266593-hmx2wy1p 190 11 for for IN cord-266593-hmx2wy1p 190 12 optimal optimal JJ cord-266593-hmx2wy1p 190 13 designs design NNS cord-266593-hmx2wy1p 190 14 were be VBD cord-266593-hmx2wy1p 190 15 consistently consistently RB cord-266593-hmx2wy1p 190 16 the the DT cord-266593-hmx2wy1p 190 17 second second JJ cord-266593-hmx2wy1p 190 18 day day NN cord-266593-hmx2wy1p 190 19 ( ( -LRB- cord-266593-hmx2wy1p 190 20 Fig Fig NNP cord-266593-hmx2wy1p 190 21 . . NNP cord-266593-hmx2wy1p 190 22 2 2 CD cord-266593-hmx2wy1p 190 23 b b NN cord-266593-hmx2wy1p 190 24 ) ) -RRB- cord-266593-hmx2wy1p 190 25 , , , cord-266593-hmx2wy1p 190 26 followed follow VBN cord-266593-hmx2wy1p 190 27 by by IN cord-266593-hmx2wy1p 190 28 other other JJ cord-266593-hmx2wy1p 190 29 days day NNS cord-266593-hmx2wy1p 190 30 early early RB cord-266593-hmx2wy1p 190 31 in in IN cord-266593-hmx2wy1p 190 32 the the DT cord-266593-hmx2wy1p 190 33 outbreak outbreak NN cord-266593-hmx2wy1p 190 34 ( ( -LRB- cord-266593-hmx2wy1p 190 35 i.e. i.e. FW cord-266593-hmx2wy1p 190 36 , , , cord-266593-hmx2wy1p 190 37 days day NNS cord-266593-hmx2wy1p 190 38 3 3 CD cord-266593-hmx2wy1p 190 39 - - SYM cord-266593-hmx2wy1p 190 40 6 6 CD cord-266593-hmx2wy1p 190 41 , , , cord-266593-hmx2wy1p 190 42 and and CC cord-266593-hmx2wy1p 190 43 day day NN cord-266593-hmx2wy1p 190 44 1 1 CD cord-266593-hmx2wy1p 190 45 ) ) -RRB- cord-266593-hmx2wy1p 190 46 . . . cord-266593-hmx2wy1p 191 1 Days day NNS cord-266593-hmx2wy1p 191 2 7 7 CD cord-266593-hmx2wy1p 191 3 - - SYM cord-266593-hmx2wy1p 191 4 14 14 CD cord-266593-hmx2wy1p 191 5 typically typically RB cord-266593-hmx2wy1p 191 6 had have VBD cord-266593-hmx2wy1p 191 7 little little JJ cord-266593-hmx2wy1p 191 8 impact impact NN cord-266593-hmx2wy1p 191 9 on on IN cord-266593-hmx2wy1p 191 10 model model NN cord-266593-hmx2wy1p 191 11 discrimination discrimination NN cord-266593-hmx2wy1p 191 12 accuracy accuracy NN cord-266593-hmx2wy1p 191 13 ( ( -LRB- cord-266593-hmx2wy1p 191 14 i.e. i.e. FW cord-266593-hmx2wy1p 191 15 , , , cord-266593-hmx2wy1p 191 16 optimal optimal JJ cord-266593-hmx2wy1p 191 17 accuracy accuracy NN cord-266593-hmx2wy1p 191 18 and and CC cord-266593-hmx2wy1p 191 19 two two CD cord-266593-hmx2wy1p 191 20 - - HYPH cord-266593-hmx2wy1p 191 21 class class NN cord-266593-hmx2wy1p 191 22 accuracy accuracy NN cord-266593-hmx2wy1p 191 23 consistently consistently RB cord-266593-hmx2wy1p 191 24 levelled level VBD cord-266593-hmx2wy1p 191 25 off off RP cord-266593-hmx2wy1p 191 26 as as IN cord-266593-hmx2wy1p 191 27 design design NN cord-266593-hmx2wy1p 191 28 size size NN cord-266593-hmx2wy1p 191 29 increased increase VBD cord-266593-hmx2wy1p 191 30 beyond beyond IN cord-266593-hmx2wy1p 191 31 5 5 CD cord-266593-hmx2wy1p 191 32 ; ; : cord-266593-hmx2wy1p 191 33 Fig Fig NNP cord-266593-hmx2wy1p 191 34 . . NNP cord-266593-hmx2wy1p 191 35 1 1 CD cord-266593-hmx2wy1p 191 36 c c NN cord-266593-hmx2wy1p 191 37 / / SYM cord-266593-hmx2wy1p 191 38 d d NNP cord-266593-hmx2wy1p 191 39 ) ) -RRB- cord-266593-hmx2wy1p 191 40 , , , cord-266593-hmx2wy1p 191 41 and and CC cord-266593-hmx2wy1p 191 42 the the DT cord-266593-hmx2wy1p 191 43 optimal optimal JJ cord-266593-hmx2wy1p 191 44 combination combination NN cord-266593-hmx2wy1p 191 45 of of IN cord-266593-hmx2wy1p 191 46 these these DT cord-266593-hmx2wy1p 191 47 days day NNS cord-266593-hmx2wy1p 191 48 varied vary VBN cord-266593-hmx2wy1p 191 49 due due IN cord-266593-hmx2wy1p 191 50 to to IN cord-266593-hmx2wy1p 191 51 stochasticity stochasticity NN cord-266593-hmx2wy1p 191 52 in in IN cord-266593-hmx2wy1p 191 53 both both DT cord-266593-hmx2wy1p 191 54 training training NN cord-266593-hmx2wy1p 191 55 and and CC cord-266593-hmx2wy1p 191 56 test test NN cord-266593-hmx2wy1p 191 57 data datum NNS cord-266593-hmx2wy1p 191 58 . . . cord-266593-hmx2wy1p 192 1 This this DT cord-266593-hmx2wy1p 192 2 is be VBZ cord-266593-hmx2wy1p 192 3 consistent consistent JJ cord-266593-hmx2wy1p 192 4 with with IN cord-266593-hmx2wy1p 192 5 the the DT cord-266593-hmx2wy1p 192 6 feature feature NN cord-266593-hmx2wy1p 192 7 importance importance NN cord-266593-hmx2wy1p 192 8 used use VBN cord-266593-hmx2wy1p 192 9 to to TO cord-266593-hmx2wy1p 192 10 develop develop VB cord-266593-hmx2wy1p 192 11 the the DT cord-266593-hmx2wy1p 192 12 heuristic heuristic JJ cord-266593-hmx2wy1p 192 13 ( ( -LRB- cord-266593-hmx2wy1p 192 14 Fig Fig NNP cord-266593-hmx2wy1p 192 15 . . . cord-266593-hmx2wy1p 192 16 1 1 CD cord-266593-hmx2wy1p 192 17 b b NN cord-266593-hmx2wy1p 192 18 ) ) -RRB- cord-266593-hmx2wy1p 192 19 , , , cord-266593-hmx2wy1p 192 20 i.e. i.e. FW cord-266593-hmx2wy1p 192 21 , , , cord-266593-hmx2wy1p 192 22 those those DT cord-266593-hmx2wy1p 192 23 days day NNS cord-266593-hmx2wy1p 192 24 that that WDT cord-266593-hmx2wy1p 192 25 were be VBD cord-266593-hmx2wy1p 192 26 consistently consistently RB cord-266593-hmx2wy1p 192 27 optimal optimal JJ cord-266593-hmx2wy1p 192 28 were be VBD cord-266593-hmx2wy1p 192 29 those those DT cord-266593-hmx2wy1p 192 30 with with IN cord-266593-hmx2wy1p 192 31 highest high JJS cord-266593-hmx2wy1p 192 32 feature feature NN cord-266593-hmx2wy1p 192 33 importance importance NN cord-266593-hmx2wy1p 192 34 . . . cord-266593-hmx2wy1p 193 1 When when WRB cord-266593-hmx2wy1p 193 2 the the DT cord-266593-hmx2wy1p 193 3 most most RBS cord-266593-hmx2wy1p 193 4 important important JJ cord-266593-hmx2wy1p 193 5 design design NN cord-266593-hmx2wy1p 193 6 point point NN cord-266593-hmx2wy1p 193 7 is be VBZ cord-266593-hmx2wy1p 193 8 visualised visualise VBN cord-266593-hmx2wy1p 193 9 ( ( -LRB- cord-266593-hmx2wy1p 193 10 Fig Fig NNP cord-266593-hmx2wy1p 193 11 . . NNP cord-266593-hmx2wy1p 193 12 2 2 CD cord-266593-hmx2wy1p 193 13 c c NN cord-266593-hmx2wy1p 193 14 ) ) -RRB- cord-266593-hmx2wy1p 193 15 it -PRON- PRP cord-266593-hmx2wy1p 193 16 shows show VBZ cord-266593-hmx2wy1p 193 17 a a DT cord-266593-hmx2wy1p 193 18 subtle subtle JJ cord-266593-hmx2wy1p 193 19 but but CC cord-266593-hmx2wy1p 193 20 clear clear JJ cord-266593-hmx2wy1p 193 21 difference difference NN cord-266593-hmx2wy1p 193 22 between between IN cord-266593-hmx2wy1p 193 23 distributions distribution NNS cord-266593-hmx2wy1p 193 24 of of IN cord-266593-hmx2wy1p 193 25 observations observation NNS cord-266593-hmx2wy1p 193 26 from from IN cord-266593-hmx2wy1p 193 27 the the DT cord-266593-hmx2wy1p 193 28 different different JJ cord-266593-hmx2wy1p 193 29 models model NNS cord-266593-hmx2wy1p 193 30 ; ; : cord-266593-hmx2wy1p 193 31 this this DT cord-266593-hmx2wy1p 193 32 provides provide VBZ cord-266593-hmx2wy1p 193 33 intuition intuition NN cord-266593-hmx2wy1p 193 34 as as IN cord-266593-hmx2wy1p 193 35 to to IN cord-266593-hmx2wy1p 193 36 how how WRB cord-266593-hmx2wy1p 193 37 decision decision NN cord-266593-hmx2wy1p 193 38 trees tree NNS cord-266593-hmx2wy1p 193 39 constructed construct VBN cord-266593-hmx2wy1p 193 40 from from IN cord-266593-hmx2wy1p 193 41 many many JJ cord-266593-hmx2wy1p 193 42 predictors predictor NNS cord-266593-hmx2wy1p 193 43 of of IN cord-266593-hmx2wy1p 193 44 this this DT cord-266593-hmx2wy1p 193 45 form form NN cord-266593-hmx2wy1p 193 46 can can MD cord-266593-hmx2wy1p 193 47 accurately accurately RB cord-266593-hmx2wy1p 193 48 discriminate discriminate VB cord-266593-hmx2wy1p 193 49 models model NNS cord-266593-hmx2wy1p 193 50 . . . cord-266593-hmx2wy1p 194 1 To to TO cord-266593-hmx2wy1p 194 2 assess assess VB cord-266593-hmx2wy1p 194 3 the the DT cord-266593-hmx2wy1p 194 4 impact impact NN cord-266593-hmx2wy1p 194 5 of of IN cord-266593-hmx2wy1p 194 6 asymptomatic asymptomatic JJ cord-266593-hmx2wy1p 194 7 infections infection NNS cord-266593-hmx2wy1p 194 8 on on IN cord-266593-hmx2wy1p 194 9 model model NN cord-266593-hmx2wy1p 194 10 discrimination discrimination NN cord-266593-hmx2wy1p 194 11 , , , cord-266593-hmx2wy1p 194 12 we -PRON- PRP cord-266593-hmx2wy1p 194 13 repeated repeat VBD cord-266593-hmx2wy1p 194 14 the the DT cord-266593-hmx2wy1p 194 15 analysis analysis NN cord-266593-hmx2wy1p 194 16 , , , cord-266593-hmx2wy1p 194 17 except except IN cord-266593-hmx2wy1p 194 18 with with IN cord-266593-hmx2wy1p 194 19 each each DT cord-266593-hmx2wy1p 194 20 individual individual NN cord-266593-hmx2wy1p 194 21 only only RB cord-266593-hmx2wy1p 194 22 being be VBG cord-266593-hmx2wy1p 194 23 symptomatic symptomatic JJ cord-266593-hmx2wy1p 194 24 ( ( -LRB- cord-266593-hmx2wy1p 194 25 at at IN cord-266593-hmx2wy1p 194 26 the the DT cord-266593-hmx2wy1p 194 27 point point NN cord-266593-hmx2wy1p 194 28 symptoms symptom NNS cord-266593-hmx2wy1p 194 29 would would MD cord-266593-hmx2wy1p 194 30 otherwise otherwise RB cord-266593-hmx2wy1p 194 31 appear appear VB cord-266593-hmx2wy1p 194 32 ) ) -RRB- cord-266593-hmx2wy1p 194 33 with with IN cord-266593-hmx2wy1p 194 34 probability probability NN cord-266593-hmx2wy1p 194 35 p p NN cord-266593-hmx2wy1p 194 36 obs obs NN cord-266593-hmx2wy1p 194 37 ( ( -LRB- cord-266593-hmx2wy1p 194 38 again again RB cord-266593-hmx2wy1p 194 39 , , , cord-266593-hmx2wy1p 194 40 sampled sample VBN cord-266593-hmx2wy1p 194 41 from from IN cord-266593-hmx2wy1p 194 42 a a DT cord-266593-hmx2wy1p 194 43 prior prior JJ cord-266593-hmx2wy1p 194 44 distribution distribution NN cord-266593-hmx2wy1p 194 45 ) ) -RRB- cord-266593-hmx2wy1p 194 46 . . . cord-266593-hmx2wy1p 195 1 This this DT cord-266593-hmx2wy1p 195 2 partial partial JJ cord-266593-hmx2wy1p 195 3 observation observation NN cord-266593-hmx2wy1p 195 4 made make VBD cord-266593-hmx2wy1p 195 5 model model NN cord-266593-hmx2wy1p 195 6 discrimination discrimination NN cord-266593-hmx2wy1p 195 7 substantially substantially RB cord-266593-hmx2wy1p 195 8 more more RBR cord-266593-hmx2wy1p 195 9 challenging challenging JJ cord-266593-hmx2wy1p 195 10 : : : cord-266593-hmx2wy1p 195 11 with with IN cord-266593-hmx2wy1p 195 12 designs design NNS cord-266593-hmx2wy1p 195 13 of of IN cord-266593-hmx2wy1p 195 14 size size NN cord-266593-hmx2wy1p 195 15 5 5 CD cord-266593-hmx2wy1p 195 16 and and CC cord-266593-hmx2wy1p 195 17 200 200 CD cord-266593-hmx2wy1p 195 18 households household NNS cord-266593-hmx2wy1p 195 19 ( ( -LRB- cord-266593-hmx2wy1p 195 20 Fig Fig NNP cord-266593-hmx2wy1p 195 21 . . NNP cord-266593-hmx2wy1p 195 22 2 2 CD cord-266593-hmx2wy1p 195 23 a a CD cord-266593-hmx2wy1p 195 24 ) ) -RRB- cord-266593-hmx2wy1p 195 25 , , , cord-266593-hmx2wy1p 195 26 accuracy accuracy NN cord-266593-hmx2wy1p 195 27 was be VBD cord-266593-hmx2wy1p 195 28 0.522 0.522 CD cord-266593-hmx2wy1p 195 29 and and CC cord-266593-hmx2wy1p 195 30 two two CD cord-266593-hmx2wy1p 195 31 - - HYPH cord-266593-hmx2wy1p 195 32 class class NN cord-266593-hmx2wy1p 195 33 accuracty accuracty NN cord-266593-hmx2wy1p 195 34 was be VBD cord-266593-hmx2wy1p 195 35 0.863 0.863 CD cord-266593-hmx2wy1p 195 36 when when WRB cord-266593-hmx2wy1p 195 37 p p NNP cord-266593-hmx2wy1p 195 38 obs obs NNP cord-266593-hmx2wy1p 195 39 ~Beta(7.5 ~Beta(7.5 NNP cord-266593-hmx2wy1p 195 40 , , , cord-266593-hmx2wy1p 195 41 2.5 2.5 CD cord-266593-hmx2wy1p 195 42 ) ) -RRB- cord-266593-hmx2wy1p 195 43 ( ( -LRB- cord-266593-hmx2wy1p 195 44 i.e. i.e. FW cord-266593-hmx2wy1p 195 45 , , , cord-266593-hmx2wy1p 195 46 a a DT cord-266593-hmx2wy1p 195 47 mean mean NN cord-266593-hmx2wy1p 195 48 of of IN cord-266593-hmx2wy1p 195 49 0.75 0.75 CD cord-266593-hmx2wy1p 195 50 ) ) -RRB- cord-266593-hmx2wy1p 195 51 , , , cord-266593-hmx2wy1p 195 52 and and CC cord-266593-hmx2wy1p 195 53 accuracy accuracy NN cord-266593-hmx2wy1p 195 54 was be VBD cord-266593-hmx2wy1p 195 55 0.400 0.400 CD cord-266593-hmx2wy1p 195 56 and and CC cord-266593-hmx2wy1p 195 57 two two CD cord-266593-hmx2wy1p 195 58 - - HYPH cord-266593-hmx2wy1p 195 59 class class NN cord-266593-hmx2wy1p 195 60 accuracy accuracy NN cord-266593-hmx2wy1p 195 61 was be VBD cord-266593-hmx2wy1p 195 62 0.736 0.736 CD cord-266593-hmx2wy1p 195 63 when when WRB cord-266593-hmx2wy1p 195 64 p p NN cord-266593-hmx2wy1p 195 65 obs obs NNP cord-266593-hmx2wy1p 195 66 ~Beta(5 ~Beta(5 NNP cord-266593-hmx2wy1p 195 67 , , , cord-266593-hmx2wy1p 195 68 5 5 CD cord-266593-hmx2wy1p 195 69 ) ) -RRB- cord-266593-hmx2wy1p 195 70 ( ( -LRB- cord-266593-hmx2wy1p 195 71 i.e. i.e. FW cord-266593-hmx2wy1p 195 72 , , , cord-266593-hmx2wy1p 195 73 a a DT cord-266593-hmx2wy1p 195 74 mean mean NN cord-266593-hmx2wy1p 195 75 of of IN cord-266593-hmx2wy1p 195 76 0.5 0.5 CD cord-266593-hmx2wy1p 195 77 ) ) -RRB- cord-266593-hmx2wy1p 195 78 ( ( -LRB- cord-266593-hmx2wy1p 195 79 compared compare VBN cord-266593-hmx2wy1p 195 80 to to IN cord-266593-hmx2wy1p 195 81 0.622 0.622 CD cord-266593-hmx2wy1p 195 82 and and CC cord-266593-hmx2wy1p 195 83 0.975 0.975 CD cord-266593-hmx2wy1p 195 84 with with IN cord-266593-hmx2wy1p 195 85 complete complete JJ cord-266593-hmx2wy1p 195 86 observation observation NN cord-266593-hmx2wy1p 195 87 ) ) -RRB- cord-266593-hmx2wy1p 195 88 . . . cord-266593-hmx2wy1p 196 1 Identifying identify VBG cord-266593-hmx2wy1p 196 2 the the DT cord-266593-hmx2wy1p 196 3 relative relative JJ cord-266593-hmx2wy1p 196 4 timing timing NN cord-266593-hmx2wy1p 196 5 of of IN cord-266593-hmx2wy1p 196 6 symptom symptom NN cord-266593-hmx2wy1p 196 7 onset onset NN cord-266593-hmx2wy1p 196 8 and and CC cord-266593-hmx2wy1p 196 9 infectiousness infectiousness NN cord-266593-hmx2wy1p 196 10 in in IN cord-266593-hmx2wy1p 196 11 an an DT cord-266593-hmx2wy1p 196 12 emerging emerge VBG cord-266593-hmx2wy1p 196 13 epidemic epidemic NN cord-266593-hmx2wy1p 196 14 is be VBZ cord-266593-hmx2wy1p 196 15 critical critical JJ cord-266593-hmx2wy1p 196 16 to to IN cord-266593-hmx2wy1p 196 17 outbreak outbreak NN cord-266593-hmx2wy1p 196 18 control control NN cord-266593-hmx2wy1p 196 19 . . . cord-266593-hmx2wy1p 197 1 We -PRON- PRP cord-266593-hmx2wy1p 197 2 have have VBP cord-266593-hmx2wy1p 197 3 demonstrated demonstrate VBN cord-266593-hmx2wy1p 197 4 , , , cord-266593-hmx2wy1p 197 5 on on IN cord-266593-hmx2wy1p 197 6 simulated simulated JJ cord-266593-hmx2wy1p 197 7 data datum NNS cord-266593-hmx2wy1p 197 8 , , , cord-266593-hmx2wy1p 197 9 a a DT cord-266593-hmx2wy1p 197 10 method method NN cord-266593-hmx2wy1p 197 11 for for IN cord-266593-hmx2wy1p 197 12 identifying identify VBG cord-266593-hmx2wy1p 197 13 the the DT cord-266593-hmx2wy1p 197 14 relative relative JJ cord-266593-hmx2wy1p 197 15 timing timing NN cord-266593-hmx2wy1p 197 16 based base VBN cord-266593-hmx2wy1p 197 17 upon upon IN cord-266593-hmx2wy1p 197 18 household household NN cord-266593-hmx2wy1p 197 19 - - HYPH cord-266593-hmx2wy1p 197 20 stratified stratify VBN cord-266593-hmx2wy1p 197 21 data datum NNS cord-266593-hmx2wy1p 197 22 available available JJ cord-266593-hmx2wy1p 197 23 early early RB cord-266593-hmx2wy1p 197 24 in in IN cord-266593-hmx2wy1p 197 25 an an DT cord-266593-hmx2wy1p 197 26 outbreak outbreak NN cord-266593-hmx2wy1p 197 27 . . . cord-266593-hmx2wy1p 198 1 This this DT cord-266593-hmx2wy1p 198 2 method method NN cord-266593-hmx2wy1p 198 3 produces produce VBZ cord-266593-hmx2wy1p 198 4 reasonable reasonable JJ cord-266593-hmx2wy1p 198 5 accuracy accuracy NN cord-266593-hmx2wy1p 198 6 for for IN cord-266593-hmx2wy1p 198 7 discriminating discriminate VBG cord-266593-hmx2wy1p 198 8 between between IN cord-266593-hmx2wy1p 198 9 five five CD cord-266593-hmx2wy1p 198 10 observation observation NN cord-266593-hmx2wy1p 198 11 models model NNS cord-266593-hmx2wy1p 198 12 , , , cord-266593-hmx2wy1p 198 13 and and CC cord-266593-hmx2wy1p 198 14 very very RB cord-266593-hmx2wy1p 198 15 high high JJ cord-266593-hmx2wy1p 198 16 accuracy accuracy NN cord-266593-hmx2wy1p 198 17 for for IN cord-266593-hmx2wy1p 198 18 determining determine VBG cord-266593-hmx2wy1p 198 19 pre pre JJ cord-266593-hmx2wy1p 198 20 - - JJ cord-266593-hmx2wy1p 198 21 or or CC cord-266593-hmx2wy1p 198 22 coincident coincident JJ cord-266593-hmx2wy1p 198 23 with with IN cord-266593-hmx2wy1p 198 24 infectiousness infectiousness NN cord-266593-hmx2wy1p 198 25 symptom symptom NN cord-266593-hmx2wy1p 198 26 onset onset NN cord-266593-hmx2wy1p 198 27 versus versus IN cord-266593-hmx2wy1p 198 28 post post JJ cord-266593-hmx2wy1p 198 29 - - JJ cord-266593-hmx2wy1p 198 30 infectiousness infectiousness JJ cord-266593-hmx2wy1p 198 31 symptom symptom NN cord-266593-hmx2wy1p 198 32 onset onset NN cord-266593-hmx2wy1p 198 33 ( ( -LRB- cord-266593-hmx2wy1p 198 34 i.e. i.e. FW cord-266593-hmx2wy1p 198 35 , , , cord-266593-hmx2wy1p 198 36 two two CD cord-266593-hmx2wy1p 198 37 - - HYPH cord-266593-hmx2wy1p 198 38 class class NN cord-266593-hmx2wy1p 198 39 accuracy accuracy NN cord-266593-hmx2wy1p 198 40 ) ) -RRB- cord-266593-hmx2wy1p 198 41 . . . cord-266593-hmx2wy1p 199 1 This this DT cord-266593-hmx2wy1p 199 2 can can MD cord-266593-hmx2wy1p 199 3 be be VB cord-266593-hmx2wy1p 199 4 done do VBN cord-266593-hmx2wy1p 199 5 without without IN cord-266593-hmx2wy1p 199 6 observing observe VBG cord-266593-hmx2wy1p 199 7 each each DT cord-266593-hmx2wy1p 199 8 household household NN cord-266593-hmx2wy1p 199 9 every every DT cord-266593-hmx2wy1p 199 10 day day NN cord-266593-hmx2wy1p 199 11 . . . cord-266593-hmx2wy1p 200 1 Moreover moreover RB cord-266593-hmx2wy1p 200 2 , , , cord-266593-hmx2wy1p 200 3 we -PRON- PRP cord-266593-hmx2wy1p 200 4 can can MD cord-266593-hmx2wy1p 200 5 use use VB cord-266593-hmx2wy1p 200 6 random random JJ cord-266593-hmx2wy1p 200 7 forest forest NN cord-266593-hmx2wy1p 200 8 feature feature NN cord-266593-hmx2wy1p 200 9 importance importance NN cord-266593-hmx2wy1p 200 10 to to TO cord-266593-hmx2wy1p 200 11 inform inform VB cord-266593-hmx2wy1p 200 12 a a DT cord-266593-hmx2wy1p 200 13 heuristic heuristic NN cord-266593-hmx2wy1p 200 14 that that WDT cord-266593-hmx2wy1p 200 15 vastly vastly RB cord-266593-hmx2wy1p 200 16 reduces reduce VBZ cord-266593-hmx2wy1p 200 17 the the DT cord-266593-hmx2wy1p 200 18 computation computation NN cord-266593-hmx2wy1p 200 19 necessary necessary JJ cord-266593-hmx2wy1p 200 20 to to TO cord-266593-hmx2wy1p 200 21 choose choose VB cord-266593-hmx2wy1p 200 22 high high JJ cord-266593-hmx2wy1p 200 23 - - HYPH cord-266593-hmx2wy1p 200 24 accuracy accuracy NN cord-266593-hmx2wy1p 200 25 designs design NNS cord-266593-hmx2wy1p 200 26 . . . cord-266593-hmx2wy1p 201 1 It -PRON- PRP cord-266593-hmx2wy1p 201 2 is be VBZ cord-266593-hmx2wy1p 201 3 remarkable remarkable JJ cord-266593-hmx2wy1p 201 4 that that IN cord-266593-hmx2wy1p 201 5 it -PRON- PRP cord-266593-hmx2wy1p 201 6 is be VBZ cord-266593-hmx2wy1p 201 7 possible possible JJ cord-266593-hmx2wy1p 201 8 to to TO cord-266593-hmx2wy1p 201 9 discriminate discriminate VB cord-266593-hmx2wy1p 201 10 models model NNS cord-266593-hmx2wy1p 201 11 so so RB cord-266593-hmx2wy1p 201 12 accurately accurately RB cord-266593-hmx2wy1p 201 13 , , , cord-266593-hmx2wy1p 201 14 given give VBN cord-266593-hmx2wy1p 201 15 that that IN cord-266593-hmx2wy1p 201 16 they -PRON- PRP cord-266593-hmx2wy1p 201 17 share share VBP cord-266593-hmx2wy1p 201 18 identical identical JJ cord-266593-hmx2wy1p 201 19 epidemic epidemic NN cord-266593-hmx2wy1p 201 20 dynamics dynamic NNS cord-266593-hmx2wy1p 201 21 , , , cord-266593-hmx2wy1p 201 22 and and CC cord-266593-hmx2wy1p 201 23 only only RB cord-266593-hmx2wy1p 201 24 differ differ VBP cord-266593-hmx2wy1p 201 25 in in IN cord-266593-hmx2wy1p 201 26 observation observation NN cord-266593-hmx2wy1p 201 27 . . . cord-266593-hmx2wy1p 202 1 The the DT cord-266593-hmx2wy1p 202 2 non non JJ cord-266593-hmx2wy1p 202 3 - - JJ cord-266593-hmx2wy1p 202 4 parametric parametric JJ cord-266593-hmx2wy1p 202 5 nature nature NN cord-266593-hmx2wy1p 202 6 of of IN cord-266593-hmx2wy1p 202 7 the the DT cord-266593-hmx2wy1p 202 8 random random JJ cord-266593-hmx2wy1p 202 9 forest forest NN cord-266593-hmx2wy1p 202 10 is be VBZ cord-266593-hmx2wy1p 202 11 able able JJ cord-266593-hmx2wy1p 202 12 to to TO cord-266593-hmx2wy1p 202 13 use use VB cord-266593-hmx2wy1p 202 14 small small JJ cord-266593-hmx2wy1p 202 15 but but CC cord-266593-hmx2wy1p 202 16 clear clear JJ cord-266593-hmx2wy1p 202 17 differences difference NNS cord-266593-hmx2wy1p 202 18 between between IN cord-266593-hmx2wy1p 202 19 models model NNS cord-266593-hmx2wy1p 202 20 ( ( -LRB- cord-266593-hmx2wy1p 202 21 e.g. e.g. RB cord-266593-hmx2wy1p 202 22 , , , cord-266593-hmx2wy1p 202 23 Fig Fig NNP cord-266593-hmx2wy1p 202 24 . . NNP cord-266593-hmx2wy1p 202 25 2 2 CD cord-266593-hmx2wy1p 202 26 c c NN cord-266593-hmx2wy1p 202 27 ) ) -RRB- cord-266593-hmx2wy1p 202 28 to to TO cord-266593-hmx2wy1p 202 29 extract extract VB cord-266593-hmx2wy1p 202 30 sufficient sufficient JJ cord-266593-hmx2wy1p 202 31 information information NN cord-266593-hmx2wy1p 202 32 to to TO cord-266593-hmx2wy1p 202 33 discriminate discriminate VB cord-266593-hmx2wy1p 202 34 them -PRON- PRP cord-266593-hmx2wy1p 202 35 . . . cord-266593-hmx2wy1p 203 1 Combining combine VBG cord-266593-hmx2wy1p 203 2 the the DT cord-266593-hmx2wy1p 203 3 raw raw JJ cord-266593-hmx2wy1p 203 4 household household NN cord-266593-hmx2wy1p 203 5 data datum NNS cord-266593-hmx2wy1p 203 6 to to TO cord-266593-hmx2wy1p 203 7 form form VB cord-266593-hmx2wy1p 203 8 summary summary NN cord-266593-hmx2wy1p 203 9 statistics statistic NNS cord-266593-hmx2wy1p 203 10 is be VBZ cord-266593-hmx2wy1p 203 11 critical critical JJ cord-266593-hmx2wy1p 203 12 to to IN cord-266593-hmx2wy1p 203 13 this this DT cord-266593-hmx2wy1p 203 14 : : : cord-266593-hmx2wy1p 203 15 if if IN cord-266593-hmx2wy1p 203 16 the the DT cord-266593-hmx2wy1p 203 17 raw raw JJ cord-266593-hmx2wy1p 203 18 household household NN cord-266593-hmx2wy1p 203 19 data datum NNS cord-266593-hmx2wy1p 203 20 is be VBZ cord-266593-hmx2wy1p 203 21 used use VBN cord-266593-hmx2wy1p 203 22 rather rather RB cord-266593-hmx2wy1p 203 23 than than IN cord-266593-hmx2wy1p 203 24 the the DT cord-266593-hmx2wy1p 203 25 summary summary NN cord-266593-hmx2wy1p 203 26 statistics statistic NNS cord-266593-hmx2wy1p 203 27 , , , cord-266593-hmx2wy1p 203 28 accuracy accuracy NN cord-266593-hmx2wy1p 203 29 is be VBZ cord-266593-hmx2wy1p 203 30 substantially substantially RB cord-266593-hmx2wy1p 203 31 lower low JJR cord-266593-hmx2wy1p 203 32 . . . cord-266593-hmx2wy1p 204 1 While while IN cord-266593-hmx2wy1p 204 2 it -PRON- PRP cord-266593-hmx2wy1p 204 3 can can MD cord-266593-hmx2wy1p 204 4 be be VB cord-266593-hmx2wy1p 204 5 difficult difficult JJ cord-266593-hmx2wy1p 204 6 to to TO cord-266593-hmx2wy1p 204 7 interpret interpret VB cord-266593-hmx2wy1p 204 8 the the DT cord-266593-hmx2wy1p 204 9 classifications classification NNS cord-266593-hmx2wy1p 204 10 made make VBN cord-266593-hmx2wy1p 204 11 by by IN cord-266593-hmx2wy1p 204 12 a a DT cord-266593-hmx2wy1p 204 13 random random JJ cord-266593-hmx2wy1p 204 14 forest forest NN cord-266593-hmx2wy1p 204 15 - - HYPH cord-266593-hmx2wy1p 204 16 classifier classifier NN cord-266593-hmx2wy1p 204 17 , , , cord-266593-hmx2wy1p 204 18 interrogating interrogate VBG cord-266593-hmx2wy1p 204 19 key key JJ cord-266593-hmx2wy1p 204 20 individual individual JJ cord-266593-hmx2wy1p 204 21 predictors predictor NNS cord-266593-hmx2wy1p 204 22 ( ( -LRB- cord-266593-hmx2wy1p 204 23 as as IN cord-266593-hmx2wy1p 204 24 in in IN cord-266593-hmx2wy1p 204 25 Fig Fig NNP cord-266593-hmx2wy1p 204 26 . . NNP cord-266593-hmx2wy1p 204 27 2 2 CD cord-266593-hmx2wy1p 204 28 c c NN cord-266593-hmx2wy1p 204 29 ) ) -RRB- cord-266593-hmx2wy1p 204 30 provides provide VBZ cord-266593-hmx2wy1p 204 31 clarity clarity NN cord-266593-hmx2wy1p 204 32 , , , cord-266593-hmx2wy1p 204 33 and and CC cord-266593-hmx2wy1p 204 34 elucidates elucidate VBZ cord-266593-hmx2wy1p 204 35 why why WRB cord-266593-hmx2wy1p 204 36 feature feature NN cord-266593-hmx2wy1p 204 37 importance importance NN cord-266593-hmx2wy1p 204 38 provides provide VBZ cord-266593-hmx2wy1p 204 39 a a DT cord-266593-hmx2wy1p 204 40 useful useful JJ cord-266593-hmx2wy1p 204 41 heuristic heuristic NN cord-266593-hmx2wy1p 204 42 for for IN cord-266593-hmx2wy1p 204 43 choosing choose VBG cord-266593-hmx2wy1p 204 44 optimal optimal JJ cord-266593-hmx2wy1p 204 45 designs design NNS cord-266593-hmx2wy1p 204 46 ( ( -LRB- cord-266593-hmx2wy1p 204 47 Molnar Molnar NNP cord-266593-hmx2wy1p 204 48 , , , cord-266593-hmx2wy1p 204 49 2019 2019 CD cord-266593-hmx2wy1p 204 50 ) ) -RRB- cord-266593-hmx2wy1p 204 51 . . . cord-266593-hmx2wy1p 205 1 The the DT cord-266593-hmx2wy1p 205 2 accuracy accuracy NN cord-266593-hmx2wy1p 205 3 of of IN cord-266593-hmx2wy1p 205 4 model model NN cord-266593-hmx2wy1p 205 5 discrimination discrimination NN cord-266593-hmx2wy1p 205 6 decreases decrease VBZ cord-266593-hmx2wy1p 205 7 substantially substantially RB cord-266593-hmx2wy1p 205 8 as as IN cord-266593-hmx2wy1p 205 9 the the DT cord-266593-hmx2wy1p 205 10 proportion proportion NN cord-266593-hmx2wy1p 205 11 of of IN cord-266593-hmx2wy1p 205 12 cases case NNS cord-266593-hmx2wy1p 205 13 that that WDT cord-266593-hmx2wy1p 205 14 are be VBP cord-266593-hmx2wy1p 205 15 asymptomatic asymptomatic JJ cord-266593-hmx2wy1p 205 16 increases increase NNS cord-266593-hmx2wy1p 205 17 . . . cord-266593-hmx2wy1p 206 1 This this DT cord-266593-hmx2wy1p 206 2 can can MD cord-266593-hmx2wy1p 206 3 be be VB cord-266593-hmx2wy1p 206 4 compensated compensate VBN cord-266593-hmx2wy1p 206 5 by by IN cord-266593-hmx2wy1p 206 6 increasing increase VBG cord-266593-hmx2wy1p 206 7 the the DT cord-266593-hmx2wy1p 206 8 number number NN cord-266593-hmx2wy1p 206 9 of of IN cord-266593-hmx2wy1p 206 10 households household NNS cord-266593-hmx2wy1p 207 1 ( ( -LRB- cord-266593-hmx2wy1p 207 2 Fig Fig NNP cord-266593-hmx2wy1p 207 3 . . NNP cord-266593-hmx2wy1p 207 4 2 2 CD cord-266593-hmx2wy1p 207 5 a a CD cord-266593-hmx2wy1p 207 6 ) ) -RRB- cord-266593-hmx2wy1p 207 7 . . . cord-266593-hmx2wy1p 208 1 The the DT cord-266593-hmx2wy1p 208 2 outbreaks outbreak NNS cord-266593-hmx2wy1p 208 3 in in IN cord-266593-hmx2wy1p 208 4 which which WDT cord-266593-hmx2wy1p 208 5 early early JJ cord-266593-hmx2wy1p 208 6 control control NN cord-266593-hmx2wy1p 208 7 is be VBZ cord-266593-hmx2wy1p 208 8 most most RBS cord-266593-hmx2wy1p 208 9 critical critical JJ cord-266593-hmx2wy1p 208 10 are be VBP cord-266593-hmx2wy1p 208 11 likely likely JJ cord-266593-hmx2wy1p 208 12 to to TO cord-266593-hmx2wy1p 208 13 be be VB cord-266593-hmx2wy1p 208 14 those those DT cord-266593-hmx2wy1p 208 15 in in IN cord-266593-hmx2wy1p 208 16 which which WDT cord-266593-hmx2wy1p 208 17 most most JJS cord-266593-hmx2wy1p 208 18 individuals individual NNS cord-266593-hmx2wy1p 208 19 are be VBP cord-266593-hmx2wy1p 208 20 symptomatic symptomatic JJ cord-266593-hmx2wy1p 208 21 , , , cord-266593-hmx2wy1p 208 22 due due IN cord-266593-hmx2wy1p 208 23 to to IN cord-266593-hmx2wy1p 208 24 symptoms symptom NNS cord-266593-hmx2wy1p 208 25 being be VBG cord-266593-hmx2wy1p 208 26 strongly strongly RB cord-266593-hmx2wy1p 208 27 correlated correlate VBN cord-266593-hmx2wy1p 208 28 with with IN cord-266593-hmx2wy1p 208 29 severity severity NN cord-266593-hmx2wy1p 208 30 , , , cord-266593-hmx2wy1p 208 31 for for IN cord-266593-hmx2wy1p 208 32 example example NN cord-266593-hmx2wy1p 208 33 hospitalisations hospitalisation NNS cord-266593-hmx2wy1p 208 34 and and CC cord-266593-hmx2wy1p 208 35 deaths death NNS cord-266593-hmx2wy1p 208 36 . . . cord-266593-hmx2wy1p 209 1 However however RB cord-266593-hmx2wy1p 209 2 , , , cord-266593-hmx2wy1p 209 3 there there EX cord-266593-hmx2wy1p 209 4 also also RB cord-266593-hmx2wy1p 209 5 exists exist VBZ cord-266593-hmx2wy1p 209 6 diseases disease NNS cord-266593-hmx2wy1p 209 7 for for IN cord-266593-hmx2wy1p 209 8 which which WDT cord-266593-hmx2wy1p 209 9 outbreak outbreak NN cord-266593-hmx2wy1p 209 10 control control NN cord-266593-hmx2wy1p 209 11 is be VBZ cord-266593-hmx2wy1p 209 12 critical critical JJ cord-266593-hmx2wy1p 209 13 , , , cord-266593-hmx2wy1p 209 14 even even RB cord-266593-hmx2wy1p 209 15 when when WRB cord-266593-hmx2wy1p 209 16 the the DT cord-266593-hmx2wy1p 209 17 proportion proportion NN cord-266593-hmx2wy1p 209 18 of of IN cord-266593-hmx2wy1p 209 19 symptomatic symptomatic JJ cord-266593-hmx2wy1p 209 20 individuals individual NNS cord-266593-hmx2wy1p 209 21 is be VBZ cord-266593-hmx2wy1p 209 22 very very RB cord-266593-hmx2wy1p 209 23 low low JJ cord-266593-hmx2wy1p 209 24 ( ( -LRB- cord-266593-hmx2wy1p 209 25 e.g. e.g. RB cord-266593-hmx2wy1p 209 26 , , , cord-266593-hmx2wy1p 209 27 poliovirus poliovirus NN cord-266593-hmx2wy1p 209 28 ) ) -RRB- cord-266593-hmx2wy1p 209 29 . . . cord-266593-hmx2wy1p 210 1 In in IN cord-266593-hmx2wy1p 210 2 some some DT cord-266593-hmx2wy1p 210 3 situations situation NNS cord-266593-hmx2wy1p 210 4 it -PRON- PRP cord-266593-hmx2wy1p 210 5 may may MD cord-266593-hmx2wy1p 210 6 be be VB cord-266593-hmx2wy1p 210 7 necessary necessary JJ cord-266593-hmx2wy1p 210 8 to to TO cord-266593-hmx2wy1p 210 9 consider consider VB cord-266593-hmx2wy1p 210 10 more more RBR cord-266593-hmx2wy1p 210 11 complicated complicated JJ cord-266593-hmx2wy1p 210 12 surveillance surveillance NN cord-266593-hmx2wy1p 210 13 schemes scheme NNS cord-266593-hmx2wy1p 210 14 , , , cord-266593-hmx2wy1p 210 15 in in IN cord-266593-hmx2wy1p 210 16 which which WDT cord-266593-hmx2wy1p 210 17 case case NN cord-266593-hmx2wy1p 210 18 it -PRON- PRP cord-266593-hmx2wy1p 210 19 may may MD cord-266593-hmx2wy1p 210 20 not not RB cord-266593-hmx2wy1p 210 21 be be VB cord-266593-hmx2wy1p 210 22 possible possible JJ cord-266593-hmx2wy1p 210 23 to to TO cord-266593-hmx2wy1p 210 24 evaluate evaluate VB cord-266593-hmx2wy1p 210 25 the the DT cord-266593-hmx2wy1p 210 26 exact exact JJ cord-266593-hmx2wy1p 210 27 optimal optimal JJ cord-266593-hmx2wy1p 210 28 design design NN cord-266593-hmx2wy1p 210 29 by by IN cord-266593-hmx2wy1p 210 30 exhaustive exhaustive JJ cord-266593-hmx2wy1p 210 31 search search NN cord-266593-hmx2wy1p 210 32 . . . cord-266593-hmx2wy1p 211 1 However however RB cord-266593-hmx2wy1p 211 2 , , , cord-266593-hmx2wy1p 211 3 the the DT cord-266593-hmx2wy1p 211 4 heuristic heuristic NN cord-266593-hmx2wy1p 211 5 proposed propose VBN cord-266593-hmx2wy1p 211 6 here here RB cord-266593-hmx2wy1p 211 7 should should MD cord-266593-hmx2wy1p 211 8 remain remain VB cord-266593-hmx2wy1p 211 9 effective effective JJ cord-266593-hmx2wy1p 211 10 in in IN cord-266593-hmx2wy1p 211 11 more more RBR cord-266593-hmx2wy1p 211 12 complicated complicated JJ cord-266593-hmx2wy1p 211 13 design design NN cord-266593-hmx2wy1p 211 14 spaces space NNS cord-266593-hmx2wy1p 211 15 , , , cord-266593-hmx2wy1p 211 16 provided provide VBN cord-266593-hmx2wy1p 211 17 they -PRON- PRP cord-266593-hmx2wy1p 211 18 have have VBP cord-266593-hmx2wy1p 211 19 a a DT cord-266593-hmx2wy1p 211 20 similar similar JJ cord-266593-hmx2wy1p 211 21 form form NN cord-266593-hmx2wy1p 211 22 , , , cord-266593-hmx2wy1p 211 23 i.e. i.e. FW cord-266593-hmx2wy1p 211 24 , , , cord-266593-hmx2wy1p 211 25 designs design NNS cord-266593-hmx2wy1p 211 26 of of IN cord-266593-hmx2wy1p 211 27 a a DT cord-266593-hmx2wy1p 211 28 given give VBN cord-266593-hmx2wy1p 211 29 size size NN cord-266593-hmx2wy1p 211 30 are be VBP cord-266593-hmx2wy1p 211 31 a a DT cord-266593-hmx2wy1p 211 32 subset subset NN cord-266593-hmx2wy1p 211 33 of of IN cord-266593-hmx2wy1p 211 34 designs design NNS cord-266593-hmx2wy1p 211 35 of of IN cord-266593-hmx2wy1p 211 36 larger large JJR cord-266593-hmx2wy1p 211 37 sizes size NNS cord-266593-hmx2wy1p 211 38 upon upon IN cord-266593-hmx2wy1p 211 39 which which WDT cord-266593-hmx2wy1p 211 40 the the DT cord-266593-hmx2wy1p 211 41 random random JJ cord-266593-hmx2wy1p 211 42 forest forest NN cord-266593-hmx2wy1p 211 43 can can MD cord-266593-hmx2wy1p 211 44 be be VB cord-266593-hmx2wy1p 211 45 trained train VBN cord-266593-hmx2wy1p 211 46 to to TO cord-266593-hmx2wy1p 211 47 extract extract VB cord-266593-hmx2wy1p 211 48 feature feature NN cord-266593-hmx2wy1p 211 49 importance importance NN cord-266593-hmx2wy1p 211 50 . . . cord-266593-hmx2wy1p 212 1 Assumptions assumption NNS cord-266593-hmx2wy1p 212 2 impact impact VBP cord-266593-hmx2wy1p 212 3 any any DT cord-266593-hmx2wy1p 212 4 model model NN cord-266593-hmx2wy1p 212 5 - - HYPH cord-266593-hmx2wy1p 212 6 based base VBN cord-266593-hmx2wy1p 212 7 study study NN cord-266593-hmx2wy1p 212 8 . . . cord-266593-hmx2wy1p 213 1 Most most RBS cord-266593-hmx2wy1p 213 2 critically critically RB cord-266593-hmx2wy1p 213 3 , , , cord-266593-hmx2wy1p 213 4 this this DT cord-266593-hmx2wy1p 213 5 model model NN cord-266593-hmx2wy1p 213 6 discrimination discrimination NN cord-266593-hmx2wy1p 213 7 process process NN cord-266593-hmx2wy1p 213 8 assumes assume VBZ cord-266593-hmx2wy1p 213 9 that that IN cord-266593-hmx2wy1p 213 10 the the DT cord-266593-hmx2wy1p 213 11 dynamics dynamic NNS cord-266593-hmx2wy1p 213 12 of of IN cord-266593-hmx2wy1p 213 13 the the DT cord-266593-hmx2wy1p 213 14 simulated simulated JJ cord-266593-hmx2wy1p 213 15 epidemic epidemic NN cord-266593-hmx2wy1p 213 16 model model NN cord-266593-hmx2wy1p 213 17 and and CC cord-266593-hmx2wy1p 213 18 observation observation NN cord-266593-hmx2wy1p 213 19 models model NNS cord-266593-hmx2wy1p 213 20 reflect reflect VBP cord-266593-hmx2wy1p 213 21 the the DT cord-266593-hmx2wy1p 213 22 actual actual JJ cord-266593-hmx2wy1p 213 23 disease disease NN cord-266593-hmx2wy1p 213 24 and and CC cord-266593-hmx2wy1p 213 25 observation observation NN cord-266593-hmx2wy1p 213 26 dynamics dynamic NNS cord-266593-hmx2wy1p 213 27 . . . cord-266593-hmx2wy1p 214 1 It -PRON- PRP cord-266593-hmx2wy1p 214 2 is be VBZ cord-266593-hmx2wy1p 214 3 possible possible JJ cord-266593-hmx2wy1p 214 4 to to TO cord-266593-hmx2wy1p 214 5 use use VB cord-266593-hmx2wy1p 214 6 this this DT cord-266593-hmx2wy1p 214 7 method method NN cord-266593-hmx2wy1p 214 8 to to TO cord-266593-hmx2wy1p 214 9 select select VB cord-266593-hmx2wy1p 214 10 between between IN cord-266593-hmx2wy1p 214 11 models model NNS cord-266593-hmx2wy1p 214 12 that that WDT cord-266593-hmx2wy1p 214 13 differ differ VBP cord-266593-hmx2wy1p 214 14 in in IN cord-266593-hmx2wy1p 214 15 dynamics dynamic NNS cord-266593-hmx2wy1p 214 16 in in IN cord-266593-hmx2wy1p 214 17 addition addition NN cord-266593-hmx2wy1p 214 18 to to IN cord-266593-hmx2wy1p 214 19 the the DT cord-266593-hmx2wy1p 214 20 observation observation NN cord-266593-hmx2wy1p 214 21 process process NN cord-266593-hmx2wy1p 214 22 ; ; : cord-266593-hmx2wy1p 214 23 however however RB cord-266593-hmx2wy1p 214 24 any any DT cord-266593-hmx2wy1p 214 25 increase increase NN cord-266593-hmx2wy1p 214 26 in in IN cord-266593-hmx2wy1p 214 27 the the DT cord-266593-hmx2wy1p 214 28 number number NN cord-266593-hmx2wy1p 214 29 of of IN cord-266593-hmx2wy1p 214 30 models model NNS cord-266593-hmx2wy1p 214 31 to to TO cord-266593-hmx2wy1p 214 32 classify classify VB cord-266593-hmx2wy1p 214 33 will will MD cord-266593-hmx2wy1p 214 34 likely likely RB cord-266593-hmx2wy1p 214 35 result result VB cord-266593-hmx2wy1p 214 36 in in IN cord-266593-hmx2wy1p 214 37 increased increase VBN cord-266593-hmx2wy1p 214 38 computation computation NN cord-266593-hmx2wy1p 214 39 and and CC cord-266593-hmx2wy1p 214 40 potentially potentially RB cord-266593-hmx2wy1p 214 41 decreased decrease VBN cord-266593-hmx2wy1p 214 42 accuracy accuracy NN cord-266593-hmx2wy1p 214 43 . . . cord-266593-hmx2wy1p 215 1 We -PRON- PRP cord-266593-hmx2wy1p 215 2 have have VBP cord-266593-hmx2wy1p 215 3 chosen choose VBN cord-266593-hmx2wy1p 215 4 to to TO cord-266593-hmx2wy1p 215 5 focus focus VB cord-266593-hmx2wy1p 215 6 on on IN cord-266593-hmx2wy1p 215 7 the the DT cord-266593-hmx2wy1p 215 8 timing timing NN cord-266593-hmx2wy1p 215 9 of of IN cord-266593-hmx2wy1p 215 10 symptom symptom NN cord-266593-hmx2wy1p 215 11 onset onset NN cord-266593-hmx2wy1p 215 12 and and CC cord-266593-hmx2wy1p 215 13 infectiousness infectiousness NN cord-266593-hmx2wy1p 215 14 in in IN cord-266593-hmx2wy1p 215 15 one one CD cord-266593-hmx2wy1p 215 16 general general JJ cord-266593-hmx2wy1p 215 17 disease disease NN cord-266593-hmx2wy1p 215 18 process process NN cord-266593-hmx2wy1p 215 19 as as IN cord-266593-hmx2wy1p 215 20 an an DT cord-266593-hmx2wy1p 215 21 example example NN cord-266593-hmx2wy1p 215 22 , , , cord-266593-hmx2wy1p 215 23 resembling resemble VBG cord-266593-hmx2wy1p 215 24 influenza influenza NN cord-266593-hmx2wy1p 215 25 in in IN cord-266593-hmx2wy1p 215 26 both both DT cord-266593-hmx2wy1p 215 27 transmission transmission NN cord-266593-hmx2wy1p 215 28 dynamics dynamic NNS cord-266593-hmx2wy1p 215 29 and and CC cord-266593-hmx2wy1p 215 30 prior prior JJ cord-266593-hmx2wy1p 215 31 distributions distribution NNS cord-266593-hmx2wy1p 215 32 on on IN cord-266593-hmx2wy1p 215 33 parameters parameter NNS cord-266593-hmx2wy1p 215 34 . . . cord-266593-hmx2wy1p 216 1 Useful useful JJ cord-266593-hmx2wy1p 216 2 future future JJ cord-266593-hmx2wy1p 216 3 work work NN cord-266593-hmx2wy1p 216 4 could could MD cord-266593-hmx2wy1p 216 5 be be VB cord-266593-hmx2wy1p 216 6 to to TO cord-266593-hmx2wy1p 216 7 perform perform VB cord-266593-hmx2wy1p 216 8 similar similar JJ cord-266593-hmx2wy1p 216 9 experiments experiment NNS cord-266593-hmx2wy1p 216 10 on on IN cord-266593-hmx2wy1p 216 11 diverse diverse JJ cord-266593-hmx2wy1p 216 12 disease disease NN cord-266593-hmx2wy1p 216 13 processes process NNS cord-266593-hmx2wy1p 216 14 , , , cord-266593-hmx2wy1p 216 15 with with IN cord-266593-hmx2wy1p 216 16 different different JJ cord-266593-hmx2wy1p 216 17 lif lif NNP cord-266593-hmx2wy1p 216 18 e e NNP cord-266593-hmx2wy1p 216 19 histories history NNS cord-266593-hmx2wy1p 216 20 . . . cord-266593-hmx2wy1p 217 1 It -PRON- PRP cord-266593-hmx2wy1p 217 2 would would MD cord-266593-hmx2wy1p 217 3 also also RB cord-266593-hmx2wy1p 217 4 be be VB cord-266593-hmx2wy1p 217 5 valuable valuable JJ cord-266593-hmx2wy1p 217 6 to to TO cord-266593-hmx2wy1p 217 7 assess assess VB cord-266593-hmx2wy1p 217 8 the the DT cord-266593-hmx2wy1p 217 9 robustness robustness NN cord-266593-hmx2wy1p 217 10 of of IN cord-266593-hmx2wy1p 217 11 the the DT cord-266593-hmx2wy1p 217 12 method method NN cord-266593-hmx2wy1p 217 13 for for IN cord-266593-hmx2wy1p 217 14 discriminating discriminate VBG cord-266593-hmx2wy1p 217 15 timing timing NN cord-266593-hmx2wy1p 217 16 of of IN cord-266593-hmx2wy1p 217 17 symptom symptom NN cord-266593-hmx2wy1p 217 18 onset onset NN cord-266593-hmx2wy1p 217 19 versus versus IN cord-266593-hmx2wy1p 217 20 infectiousness infectiousness NN cord-266593-hmx2wy1p 217 21 when when WRB cord-266593-hmx2wy1p 217 22 the the DT cord-266593-hmx2wy1p 217 23 underlying underlie VBG cord-266593-hmx2wy1p 217 24 disease disease NN cord-266593-hmx2wy1p 217 25 transmission transmission NN cord-266593-hmx2wy1p 217 26 model model NN cord-266593-hmx2wy1p 217 27 is be VBZ cord-266593-hmx2wy1p 217 28 misspecified misspecifie VBN cord-266593-hmx2wy1p 217 29 . . . cord-266593-hmx2wy1p 218 1 We -PRON- PRP cord-266593-hmx2wy1p 218 2 note note VBP cord-266593-hmx2wy1p 218 3 that that IN cord-266593-hmx2wy1p 218 4 selection selection NN cord-266593-hmx2wy1p 218 5 between between IN cord-266593-hmx2wy1p 218 6 different different JJ cord-266593-hmx2wy1p 218 7 transmission transmission NN cord-266593-hmx2wy1p 218 8 models model NNS cord-266593-hmx2wy1p 218 9 ( ( -LRB- cord-266593-hmx2wy1p 218 10 rather rather RB cord-266593-hmx2wy1p 218 11 than than IN cord-266593-hmx2wy1p 218 12 observation observation NN cord-266593-hmx2wy1p 218 13 models model NNS cord-266593-hmx2wy1p 218 14 ) ) -RRB- cord-266593-hmx2wy1p 218 15 for for IN cord-266593-hmx2wy1p 218 16 disease disease NN cord-266593-hmx2wy1p 218 17 outbreaks outbreak NNS cord-266593-hmx2wy1p 218 18 has have VBZ cord-266593-hmx2wy1p 218 19 been be VBN cord-266593-hmx2wy1p 218 20 considered consider VBN cord-266593-hmx2wy1p 218 21 in in IN cord-266593-hmx2wy1p 218 22 other other JJ cord-266593-hmx2wy1p 218 23 studies study NNS cord-266593-hmx2wy1p 218 24 , , , cord-266593-hmx2wy1p 218 25 for for IN cord-266593-hmx2wy1p 218 26 example example NN cord-266593-hmx2wy1p 218 27 , , , cord-266593-hmx2wy1p 218 28 assessing assess VBG cord-266593-hmx2wy1p 218 29 models model NNS cord-266593-hmx2wy1p 218 30 of of IN cord-266593-hmx2wy1p 218 31 transmissibility transmissibility NN cord-266593-hmx2wy1p 218 32 over over IN cord-266593-hmx2wy1p 218 33 time time NN cord-266593-hmx2wy1p 218 34 for for IN cord-266593-hmx2wy1p 218 35 Norovirus Norovirus NNP cord-266593-hmx2wy1p 218 36 from from IN cord-266593-hmx2wy1p 218 37 household household NN cord-266593-hmx2wy1p 218 38 data datum NNS cord-266593-hmx2wy1p 219 1 ( ( -LRB- cord-266593-hmx2wy1p 219 2 Zelner Zelner NNP cord-266593-hmx2wy1p 219 3 et et NNP cord-266593-hmx2wy1p 219 4 al al NNP cord-266593-hmx2wy1p 219 5 . . NNP cord-266593-hmx2wy1p 219 6 , , , cord-266593-hmx2wy1p 219 7 2013 2013 CD cord-266593-hmx2wy1p 219 8 ) ) -RRB- cord-266593-hmx2wy1p 219 9 . . . cord-266593-hmx2wy1p 220 1 In in IN cord-266593-hmx2wy1p 220 2 addition addition NN cord-266593-hmx2wy1p 220 3 , , , cord-266593-hmx2wy1p 220 4 the the DT cord-266593-hmx2wy1p 220 5 simulation simulation NN cord-266593-hmx2wy1p 220 6 study study NN cord-266593-hmx2wy1p 220 7 we -PRON- PRP cord-266593-hmx2wy1p 220 8 present present VBP cord-266593-hmx2wy1p 220 9 is be VBZ cord-266593-hmx2wy1p 220 10 a a DT cord-266593-hmx2wy1p 220 11 simplification simplification NN cord-266593-hmx2wy1p 220 12 of of IN cord-266593-hmx2wy1p 220 13 realistic realistic JJ cord-266593-hmx2wy1p 220 14 disease disease NN cord-266593-hmx2wy1p 220 15 dynamics dynamic NNS cord-266593-hmx2wy1p 220 16 . . . cord-266593-hmx2wy1p 221 1 The the DT cord-266593-hmx2wy1p 221 2 model model NN cord-266593-hmx2wy1p 221 3 assumes assume VBZ cord-266593-hmx2wy1p 221 4 homogeneous homogeneous JJ cord-266593-hmx2wy1p 221 5 within within IN cord-266593-hmx2wy1p 221 6 - - HYPH cord-266593-hmx2wy1p 221 7 household household NN cord-266593-hmx2wy1p 221 8 mixing mixing NN cord-266593-hmx2wy1p 221 9 , , , cord-266593-hmx2wy1p 221 10 Erlang Erlang NNP cord-266593-hmx2wy1p 221 11 - - HYPH cord-266593-hmx2wy1p 221 12 distributed distribute VBN cord-266593-hmx2wy1p 221 13 latent latent JJ cord-266593-hmx2wy1p 221 14 and and CC cord-266593-hmx2wy1p 221 15 infectious infectious JJ cord-266593-hmx2wy1p 221 16 durations duration NNS cord-266593-hmx2wy1p 221 17 , , , cord-266593-hmx2wy1p 221 18 and and CC cord-266593-hmx2wy1p 221 19 constant constant JJ cord-266593-hmx2wy1p 221 20 transmission transmission NN cord-266593-hmx2wy1p 221 21 rates rate NNS cord-266593-hmx2wy1p 221 22 over over IN cord-266593-hmx2wy1p 221 23 the the DT cord-266593-hmx2wy1p 221 24 infectious infectious JJ cord-266593-hmx2wy1p 221 25 period period NN cord-266593-hmx2wy1p 221 26 . . . cord-266593-hmx2wy1p 222 1 Independence independence NN cord-266593-hmx2wy1p 222 2 between between IN cord-266593-hmx2wy1p 222 3 households household NNS cord-266593-hmx2wy1p 222 4 is be VBZ cord-266593-hmx2wy1p 222 5 also also RB cord-266593-hmx2wy1p 222 6 assumed assume VBN cord-266593-hmx2wy1p 222 7 ( ( -LRB- cord-266593-hmx2wy1p 222 8 i.e. i.e. FW cord-266593-hmx2wy1p 222 9 , , , cord-266593-hmx2wy1p 222 10 that that IN cord-266593-hmx2wy1p 222 11 once once RB cord-266593-hmx2wy1p 222 12 a a DT cord-266593-hmx2wy1p 222 13 household household NN cord-266593-hmx2wy1p 222 14 is be VBZ cord-266593-hmx2wy1p 222 15 infected infect VBN cord-266593-hmx2wy1p 222 16 , , , cord-266593-hmx2wy1p 222 17 all all DT cord-266593-hmx2wy1p 222 18 subsequent subsequent JJ cord-266593-hmx2wy1p 222 19 infection infection NN cord-266593-hmx2wy1p 222 20 events event NNS cord-266593-hmx2wy1p 222 21 are be VBP cord-266593-hmx2wy1p 222 22 due due JJ cord-266593-hmx2wy1p 222 23 to to IN cord-266593-hmx2wy1p 222 24 transmission transmission NN cord-266593-hmx2wy1p 222 25 within within IN cord-266593-hmx2wy1p 222 26 that that DT cord-266593-hmx2wy1p 222 27 household household NN cord-266593-hmx2wy1p 222 28 ) ) -RRB- cord-266593-hmx2wy1p 222 29 ; ; : cord-266593-hmx2wy1p 222 30 this this DT cord-266593-hmx2wy1p 222 31 is be VBZ cord-266593-hmx2wy1p 222 32 only only RB cord-266593-hmx2wy1p 222 33 potentially potentially RB cord-266593-hmx2wy1p 222 34 valid valid JJ cord-266593-hmx2wy1p 222 35 in in IN cord-266593-hmx2wy1p 222 36 the the DT cord-266593-hmx2wy1p 222 37 case case NN cord-266593-hmx2wy1p 222 38 of of IN cord-266593-hmx2wy1p 222 39 a a DT cord-266593-hmx2wy1p 222 40 large large JJ cord-266593-hmx2wy1p 222 41 population population NN cord-266593-hmx2wy1p 222 42 of of IN cord-266593-hmx2wy1p 222 43 households household NNS cord-266593-hmx2wy1p 222 44 and and CC cord-266593-hmx2wy1p 222 45 the the DT cord-266593-hmx2wy1p 222 46 early early JJ cord-266593-hmx2wy1p 222 47 stages stage NNS cord-266593-hmx2wy1p 222 48 of of IN cord-266593-hmx2wy1p 222 49 an an DT cord-266593-hmx2wy1p 222 50 outbreak outbreak NN cord-266593-hmx2wy1p 222 51 . . . cord-266593-hmx2wy1p 223 1 Household household NN cord-266593-hmx2wy1p 223 2 size size NN cord-266593-hmx2wy1p 223 3 is be VBZ cord-266593-hmx2wy1p 223 4 uniform uniform JJ cord-266593-hmx2wy1p 223 5 across across IN cord-266593-hmx2wy1p 223 6 households household NNS cord-266593-hmx2wy1p 223 7 within within IN cord-266593-hmx2wy1p 223 8 the the DT cord-266593-hmx2wy1p 223 9 simulation simulation NN cord-266593-hmx2wy1p 223 10 ; ; : cord-266593-hmx2wy1p 223 11 if if IN cord-266593-hmx2wy1p 223 12 household household NN cord-266593-hmx2wy1p 223 13 size size NN cord-266593-hmx2wy1p 223 14 were be VBD cord-266593-hmx2wy1p 223 15 allowed allow VBN cord-266593-hmx2wy1p 223 16 to to TO cord-266593-hmx2wy1p 223 17 vary vary VB cord-266593-hmx2wy1p 223 18 , , , cord-266593-hmx2wy1p 223 19 data datum NNS cord-266593-hmx2wy1p 223 20 from from IN cord-266593-hmx2wy1p 223 21 each each DT cord-266593-hmx2wy1p 223 22 household household NN cord-266593-hmx2wy1p 223 23 size size NN cord-266593-hmx2wy1p 223 24 would would MD cord-266593-hmx2wy1p 223 25 need need VB cord-266593-hmx2wy1p 223 26 to to TO cord-266593-hmx2wy1p 223 27 be be VB cord-266593-hmx2wy1p 223 28 evaluated evaluate VBN cord-266593-hmx2wy1p 223 29 separately separately RB cord-266593-hmx2wy1p 223 30 , , , cord-266593-hmx2wy1p 223 31 and and CC cord-266593-hmx2wy1p 223 32 more more JJR cord-266593-hmx2wy1p 223 33 households household NNS cord-266593-hmx2wy1p 223 34 may may MD cord-266593-hmx2wy1p 223 35 need need VB cord-266593-hmx2wy1p 223 36 to to TO cord-266593-hmx2wy1p 223 37 be be VB cord-266593-hmx2wy1p 223 38 observed observe VBN cord-266593-hmx2wy1p 223 39 to to TO cord-266593-hmx2wy1p 223 40 obtain obtain VB cord-266593-hmx2wy1p 223 41 suitable suitable JJ cord-266593-hmx2wy1p 223 42 accuracy accuracy NN cord-266593-hmx2wy1p 223 43 . . . cord-266593-hmx2wy1p 224 1 Assessing assess VBG cord-266593-hmx2wy1p 224 2 optimal optimal JJ cord-266593-hmx2wy1p 224 3 design design NN cord-266593-hmx2wy1p 224 4 for for IN cord-266593-hmx2wy1p 224 5 model model NN cord-266593-hmx2wy1p 224 6 discrimination discrimination NN cord-266593-hmx2wy1p 224 7 given give VBN cord-266593-hmx2wy1p 224 8 a a DT cord-266593-hmx2wy1p 224 9 range range NN cord-266593-hmx2wy1p 224 10 of of IN cord-266593-hmx2wy1p 224 11 household household NN cord-266593-hmx2wy1p 224 12 sizes size NNS cord-266593-hmx2wy1p 224 13 would would MD cord-266593-hmx2wy1p 224 14 be be VB cord-266593-hmx2wy1p 224 15 a a DT cord-266593-hmx2wy1p 224 16 valuable valuable JJ cord-266593-hmx2wy1p 224 17 direction direction NN cord-266593-hmx2wy1p 224 18 for for IN cord-266593-hmx2wy1p 224 19 future future JJ cord-266593-hmx2wy1p 224 20 work work NN cord-266593-hmx2wy1p 224 21 . . . cord-266593-hmx2wy1p 225 1 Finally finally RB cord-266593-hmx2wy1p 225 2 , , , cord-266593-hmx2wy1p 225 3 we -PRON- PRP cord-266593-hmx2wy1p 225 4 treat treat VBP cord-266593-hmx2wy1p 225 5 the the DT cord-266593-hmx2wy1p 225 6 interaction interaction NN cord-266593-hmx2wy1p 225 7 between between IN cord-266593-hmx2wy1p 225 8 symptom symptom NN cord-266593-hmx2wy1p 225 9 onset onset NN cord-266593-hmx2wy1p 225 10 and and CC cord-266593-hmx2wy1p 225 11 infectiousness infectiousness NN cord-266593-hmx2wy1p 225 12 as as IN cord-266593-hmx2wy1p 225 13 a a DT cord-266593-hmx2wy1p 225 14 discrete discrete JJ cord-266593-hmx2wy1p 225 15 process process NN cord-266593-hmx2wy1p 225 16 ( ( -LRB- cord-266593-hmx2wy1p 225 17 i.e. i.e. FW cord-266593-hmx2wy1p 225 18 , , , cord-266593-hmx2wy1p 225 19 symptom symptom NN cord-266593-hmx2wy1p 225 20 onset onset NN cord-266593-hmx2wy1p 225 21 coincides coincide VBZ cord-266593-hmx2wy1p 225 22 exactly exactly RB cord-266593-hmx2wy1p 225 23 with with IN cord-266593-hmx2wy1p 225 24 transitions transition NNS cord-266593-hmx2wy1p 225 25 between between IN cord-266593-hmx2wy1p 225 26 states state NNS cord-266593-hmx2wy1p 225 27 ) ) -RRB- cord-266593-hmx2wy1p 225 28 , , , cord-266593-hmx2wy1p 225 29 whereas whereas IN cord-266593-hmx2wy1p 225 30 this this DT cord-266593-hmx2wy1p 225 31 process process NN cord-266593-hmx2wy1p 225 32 may may MD cord-266593-hmx2wy1p 225 33 be be VB cord-266593-hmx2wy1p 225 34 more more RBR cord-266593-hmx2wy1p 225 35 general general JJ cord-266593-hmx2wy1p 225 36 in in IN cord-266593-hmx2wy1p 225 37 practice practice NN cord-266593-hmx2wy1p 225 38 . . . cord-266593-hmx2wy1p 226 1 This this DT cord-266593-hmx2wy1p 226 2 paper paper NN cord-266593-hmx2wy1p 226 3 demonstrates demonstrate VBZ cord-266593-hmx2wy1p 226 4 an an DT cord-266593-hmx2wy1p 226 5 example example NN cord-266593-hmx2wy1p 226 6 of of IN cord-266593-hmx2wy1p 226 7 the the DT cord-266593-hmx2wy1p 226 8 process process NN cord-266593-hmx2wy1p 226 9 of of IN cord-266593-hmx2wy1p 226 10 Bayesian bayesian JJ cord-266593-hmx2wy1p 226 11 model model NN cord-266593-hmx2wy1p 226 12 discrimination discrimination NN cord-266593-hmx2wy1p 226 13 for for IN cord-266593-hmx2wy1p 226 14 outbreak outbreak NN cord-266593-hmx2wy1p 226 15 control control NN cord-266593-hmx2wy1p 226 16 , , , cord-266593-hmx2wy1p 226 17 and and CC cord-266593-hmx2wy1p 226 18 could could MD cord-266593-hmx2wy1p 226 19 be be VB cord-266593-hmx2wy1p 226 20 adapted adapt VBN cord-266593-hmx2wy1p 226 21 to to IN cord-266593-hmx2wy1p 226 22 more more RBR cord-266593-hmx2wy1p 226 23 complex complex JJ cord-266593-hmx2wy1p 226 24 disease disease NN cord-266593-hmx2wy1p 226 25 models model NNS cord-266593-hmx2wy1p 226 26 as as IN cord-266593-hmx2wy1p 226 27 desired desire VBN cord-266593-hmx2wy1p 226 28 . . . cord-266593-hmx2wy1p 227 1 In in IN cord-266593-hmx2wy1p 227 2 the the DT cord-266593-hmx2wy1p 227 3 future future NN cord-266593-hmx2wy1p 227 4 , , , cord-266593-hmx2wy1p 227 5 the the DT cord-266593-hmx2wy1p 227 6 aim aim NN cord-266593-hmx2wy1p 227 7 is be VBZ cord-266593-hmx2wy1p 227 8 to to TO cord-266593-hmx2wy1p 227 9 combine combine VB cord-266593-hmx2wy1p 227 10 Bayesian bayesian JJ cord-266593-hmx2wy1p 227 11 model model NN cord-266593-hmx2wy1p 227 12 discrimination discrimination NN cord-266593-hmx2wy1p 227 13 and and CC cord-266593-hmx2wy1p 227 14 parameter parameter NN cord-266593-hmx2wy1p 227 15 estimation estimation NN cord-266593-hmx2wy1p 227 16 in in IN cord-266593-hmx2wy1p 227 17 an an DT cord-266593-hmx2wy1p 227 18 online online JJ cord-266593-hmx2wy1p 227 19 manner manner NN cord-266593-hmx2wy1p 227 20 . . . cord-266593-hmx2wy1p 228 1 Improving improve VBG cord-266593-hmx2wy1p 228 2 estimates estimate NNS cord-266593-hmx2wy1p 228 3 of of IN cord-266593-hmx2wy1p 228 4 parameters parameter NNS cord-266593-hmx2wy1p 228 5 improves improve VBZ cord-266593-hmx2wy1p 228 6 the the DT cord-266593-hmx2wy1p 228 7 ability ability NN cord-266593-hmx2wy1p 228 8 to to TO cord-266593-hmx2wy1p 228 9 discriminate discriminate VB cord-266593-hmx2wy1p 228 10 models model NNS cord-266593-hmx2wy1p 228 11 , , , cord-266593-hmx2wy1p 228 12 and and CC cord-266593-hmx2wy1p 228 13 , , , cord-266593-hmx2wy1p 228 14 more more JJR cord-266593-hmx2wy1p 228 15 certainty certainty NN cord-266593-hmx2wy1p 228 16 regarding regard VBG cord-266593-hmx2wy1p 228 17 the the DT cord-266593-hmx2wy1p 228 18 model model NN cord-266593-hmx2wy1p 228 19 likely likely RB cord-266593-hmx2wy1p 228 20 reduces reduce VBZ cord-266593-hmx2wy1p 228 21 variance variance NN cord-266593-hmx2wy1p 228 22 in in IN cord-266593-hmx2wy1p 228 23 parameter parameter NN cord-266593-hmx2wy1p 228 24 estimates estimate NNS cord-266593-hmx2wy1p 228 25 . . . cord-266593-hmx2wy1p 229 1 This this DT cord-266593-hmx2wy1p 229 2 would would MD cord-266593-hmx2wy1p 229 3 allow allow VB cord-266593-hmx2wy1p 229 4 for for IN cord-266593-hmx2wy1p 229 5 unified unified JJ cord-266593-hmx2wy1p 229 6 characterisation characterisation NN cord-266593-hmx2wy1p 229 7 of of IN cord-266593-hmx2wy1p 229 8 all all DT cord-266593-hmx2wy1p 229 9 factors factor NNS cord-266593-hmx2wy1p 229 10 influencing influence VBG cord-266593-hmx2wy1p 229 11 the the DT cord-266593-hmx2wy1p 229 12 ability ability NN cord-266593-hmx2wy1p 229 13 to to TO cord-266593-hmx2wy1p 229 14 control control VB cord-266593-hmx2wy1p 229 15 an an DT cord-266593-hmx2wy1p 229 16 outbreak outbreak NN cord-266593-hmx2wy1p 229 17 . . . cord-266593-hmx2wy1p 229 18 _SP cord-266593-hmx2wy1p 230 1 Model model NN cord-266593-hmx2wy1p 230 2 selection selection NN cord-266593-hmx2wy1p 230 3 for for IN cord-266593-hmx2wy1p 230 4 time time NN cord-266593-hmx2wy1p 230 5 series series NNP cord-266593-hmx2wy1p 230 6 of of IN cord-266593-hmx2wy1p 230 7 count count NN cord-266593-hmx2wy1p 230 8 data datum NNS cord-266593-hmx2wy1p 230 9 Epidemiology epidemiology NN cord-266593-hmx2wy1p 230 10 , , , cord-266593-hmx2wy1p 230 11 transmission transmission NN cord-266593-hmx2wy1p 230 12 dynamics dynamic NNS cord-266593-hmx2wy1p 230 13 and and CC cord-266593-hmx2wy1p 230 14 control control NN cord-266593-hmx2wy1p 230 15 of of IN cord-266593-hmx2wy1p 230 16 SARS SARS NNP cord-266593-hmx2wy1p 230 17 : : : cord-266593-hmx2wy1p 230 18 the the DT cord-266593-hmx2wy1p 230 19 20 20 CD cord-266593-hmx2wy1p 230 20 02 02 CD cord-266593-hmx2wy1p 230 21 - - SYM cord-266593-hmx2wy1p 230 22 20 20 CD cord-266593-hmx2wy1p 230 23 03 03 CD cord-266593-hmx2wy1p 230 24 epidemic epidemic NN cord-266593-hmx2wy1p 230 25 Epidemiological epidemiological JJ cord-266593-hmx2wy1p 230 26 consequences consequence NNS cord-266593-hmx2wy1p 230 27 of of IN cord-266593-hmx2wy1p 230 28 household household NN cord-266593-hmx2wy1p 230 29 - - HYPH cord-266593-hmx2wy1p 230 30 based base VBN cord-266593-hmx2wy1p 230 31 antiviral antiviral JJ cord-266593-hmx2wy1p 230 32 prophylaxis prophylaxis NN cord-266593-hmx2wy1p 230 33 for for IN cord-266593-hmx2wy1p 230 34 pandemic pandemic NN cord-266593-hmx2wy1p 230 35 influenza influenza NN cord-266593-hmx2wy1p 230 36 Characterising characterise VBG cord-266593-hmx2wy1p 230 37 pandemic pandemic NN cord-266593-hmx2wy1p 230 38 severity severity NN cord-266593-hmx2wy1p 230 39 and and CC cord-266593-hmx2wy1p 230 40 transmissibility transmissibility NN cord-266593-hmx2wy1p 230 41 from from IN cord-266593-hmx2wy1p 230 42 data datum NNS cord-266593-hmx2wy1p 230 43 collected collect VBN cord-266593-hmx2wy1p 230 44 during during IN cord-266593-hmx2wy1p 230 45 first first JJ cord-266593-hmx2wy1p 230 46 few few JJ cord-266593-hmx2wy1p 230 47 hundred hundred CD cord-266593-hmx2wy1p 230 48 studies study NNS cord-266593-hmx2wy1p 231 1 Bayesian bayesian JJ cord-266593-hmx2wy1p 231 2 experimental experimental JJ cord-266593-hmx2wy1p 231 3 design design NN cord-266593-hmx2wy1p 231 4 : : : cord-266593-hmx2wy1p 231 5 a a DT cord-266593-hmx2wy1p 231 6 review review NN cord-266593-hmx2wy1p 231 7 Relationship relationship NN cord-266593-hmx2wy1p 231 8 between between IN cord-266593-hmx2wy1p 231 9 clinical clinical JJ cord-266593-hmx2wy1p 231 10 signs sign NNS cord-266593-hmx2wy1p 231 11 and and CC cord-266593-hmx2wy1p 231 12 transmission transmission NN cord-266593-hmx2wy1p 231 13 of of IN cord-266593-hmx2wy1p 231 14 an an DT cord-266593-hmx2wy1p 231 15 infectious infectious JJ cord-266593-hmx2wy1p 231 16 disease disease NN cord-266593-hmx2wy1p 231 17 and and CC cord-266593-hmx2wy1p 231 18 the the DT cord-266593-hmx2wy1p 231 19 implications implication NNS cord-266593-hmx2wy1p 231 20 for for IN cord-266593-hmx2wy1p 231 21 control control NN cord-266593-hmx2wy1p 231 22 SMC2 SMC2 NNP cord-266593-hmx2wy1p 231 23 : : : cord-266593-hmx2wy1p 232 1 An an DT cord-266593-hmx2wy1p 232 2 efficient efficient JJ cord-266593-hmx2wy1p 232 3 algorithm algorithm NN cord-266593-hmx2wy1p 232 4 for for IN cord-266593-hmx2wy1p 232 5 sequential sequential JJ cord-266593-hmx2wy1p 232 6 analysis analysis NN cord-266593-hmx2wy1p 232 7 of of IN cord-266593-hmx2wy1p 232 8 state state NN cord-266593-hmx2wy1p 232 9 space space NN cord-266593-hmx2wy1p 232 10 models model NNS cord-266593-hmx2wy1p 233 1 When when WRB cord-266593-hmx2wy1p 233 2 is be VBZ cord-266593-hmx2wy1p 233 3 quarantine quarantine VB cord-266593-hmx2wy1p 233 4 a a DT cord-266593-hmx2wy1p 233 5 useful useful JJ cord-266593-hmx2wy1p 233 6 control control NN cord-266593-hmx2wy1p 233 7 strategy strategy NN cord-266593-hmx2wy1p 233 8 for for IN cord-266593-hmx2wy1p 233 9 emerging emerge VBG cord-266593-hmx2wy1p 233 10 infectious infectious JJ cord-266593-hmx2wy1p 233 11 diseases disease NNS cord-266593-hmx2wy1p 233 12 ? ? . cord-266593-hmx2wy1p 234 1 Optimal optimal JJ cord-266593-hmx2wy1p 234 2 bayesian bayesian JJ cord-266593-hmx2wy1p 234 3 design design NN cord-266593-hmx2wy1p 234 4 for for IN cord-266593-hmx2wy1p 234 5 discriminating discriminate VBG cord-266593-hmx2wy1p 234 6 between between IN cord-266593-hmx2wy1p 234 7 models model NNS cord-266593-hmx2wy1p 234 8 with with IN cord-266593-hmx2wy1p 234 9 intractable intractable JJ cord-266593-hmx2wy1p 234 10 likelihoods likelihood NNS cord-266593-hmx2wy1p 234 11 in in IN cord-266593-hmx2wy1p 234 12 epidemiology epidemiology NN cord-266593-hmx2wy1p 234 13 . . . cord-266593-hmx2wy1p 235 1 Comput Comput NNP cord-266593-hmx2wy1p 236 1 Alive alive JJ cord-266593-hmx2wy1p 236 2 SMC2 SMC2 NNP cord-266593-hmx2wy1p 236 3 : : : cord-266593-hmx2wy1p 237 1 Bayesian bayesian JJ cord-266593-hmx2wy1p 237 2 model model NN cord-266593-hmx2wy1p 237 3 selection selection NN cord-266593-hmx2wy1p 237 4 for for IN cord-266593-hmx2wy1p 237 5 lowcount lowcount NNP cord-266593-hmx2wy1p 237 6 time time NNP cord-266593-hmx2wy1p 237 7 series series NNP cord-266593-hmx2wy1p 237 8 models model NNS cord-266593-hmx2wy1p 237 9 with with IN cord-266593-hmx2wy1p 237 10 intractable intractable JJ cord-266593-hmx2wy1p 237 11 likelihoods likelihood NNS cord-266593-hmx2wy1p 237 12 Factors factor NNS cord-266593-hmx2wy1p 237 13 that that WDT cord-266593-hmx2wy1p 237 14 make make VBP cord-266593-hmx2wy1p 237 15 an an DT cord-266593-hmx2wy1p 237 16 infectious infectious JJ cord-266593-hmx2wy1p 237 17 disease disease NN cord-266593-hmx2wy1p 237 18 outbreak outbreak NN cord-266593-hmx2wy1p 237 19 controllable controllable JJ cord-266593-hmx2wy1p 237 20 Optimal Optimal NNP cord-266593-hmx2wy1p 237 21 bayesian bayesian JJ cord-266593-hmx2wy1p 237 22 design design NN cord-266593-hmx2wy1p 237 23 for for IN cord-266593-hmx2wy1p 237 24 model model NN cord-266593-hmx2wy1p 237 25 discrimination discrimination NN cord-266593-hmx2wy1p 237 26 via via IN cord-266593-hmx2wy1p 237 27 classification classification NN cord-266593-hmx2wy1p 238 1 The the DT cord-266593-hmx2wy1p 238 2 Elements Elements NNPS cord-266593-hmx2wy1p 238 3 of of IN cord-266593-hmx2wy1p 238 4 Statistical Statistical NNP cord-266593-hmx2wy1p 238 5 Learning Learning NNP cord-266593-hmx2wy1p 238 6 Quarantine Quarantine NNP cord-266593-hmx2wy1p 238 7 for for IN cord-266593-hmx2wy1p 238 8 SARS SARS NNP cord-266593-hmx2wy1p 238 9 , , , cord-266593-hmx2wy1p 238 10 taiwan taiwan NNP cord-266593-hmx2wy1p 238 11 Exposure Exposure NNP cord-266593-hmx2wy1p 238 12 patterns pattern NNS cord-266593-hmx2wy1p 238 13 driving drive VBG cord-266593-hmx2wy1p 238 14 ebola ebola NNP cord-266593-hmx2wy1p 238 15 transmission transmission NN cord-266593-hmx2wy1p 238 16 in in IN cord-266593-hmx2wy1p 238 17 west west NNP cord-266593-hmx2wy1p 238 18 africa africa NNP cord-266593-hmx2wy1p 238 19 : : : cord-266593-hmx2wy1p 238 20 a a DT cord-266593-hmx2wy1p 238 21 retrospective retrospective JJ cord-266593-hmx2wy1p 238 22 observational observational JJ cord-266593-hmx2wy1p 238 23 study study NN cord-266593-hmx2wy1p 238 24 On on IN cord-266593-hmx2wy1p 238 25 methods method NNS cord-266593-hmx2wy1p 238 26 for for IN cord-266593-hmx2wy1p 238 27 studying study VBG cord-266593-hmx2wy1p 238 28 stochastic stochastic JJ cord-266593-hmx2wy1p 238 29 disease disease NN cord-266593-hmx2wy1p 238 30 dynamics dynamic NNS cord-266593-hmx2wy1p 239 1 A a DT cord-266593-hmx2wy1p 239 2 novel novel JJ cord-266593-hmx2wy1p 239 3 coronavirus coronavirus NN cord-266593-hmx2wy1p 239 4 associated associate VBN cord-266593-hmx2wy1p 239 5 with with IN cord-266593-hmx2wy1p 239 6 severe severe JJ cord-266593-hmx2wy1p 239 7 acute acute JJ cord-266593-hmx2wy1p 239 8 respiratory respiratory JJ cord-266593-hmx2wy1p 239 9 syndrome syndrome NN cord-266593-hmx2wy1p 239 10 Viral viral JJ cord-266593-hmx2wy1p 239 11 shedding shed VBG cord-266593-hmx2wy1p 239 12 and and CC cord-266593-hmx2wy1p 239 13 clinical clinical JJ cord-266593-hmx2wy1p 239 14 illness illness NN cord-266593-hmx2wy1p 239 15 in in IN cord-266593-hmx2wy1p 239 16 naturally naturally RB cord-266593-hmx2wy1p 239 17 acquired acquire VBN cord-266593-hmx2wy1p 239 18 influenza influenza NN cord-266593-hmx2wy1p 239 19 virus virus NN cord-266593-hmx2wy1p 239 20 infections infection NNS cord-266593-hmx2wy1p 240 1 A a DT cord-266593-hmx2wy1p 240 2 major major JJ cord-266593-hmx2wy1p 240 3 outbreak outbreak NN cord-266593-hmx2wy1p 240 4 of of IN cord-266593-hmx2wy1p 240 5 severe severe JJ cord-266593-hmx2wy1p 240 6 acute acute JJ cord-266593-hmx2wy1p 240 7 respiratory respiratory JJ cord-266593-hmx2wy1p 240 8 syndrome syndrome NN cord-266593-hmx2wy1p 240 9 in in IN cord-266593-hmx2wy1p 240 10 hong hong NNP cord-266593-hmx2wy1p 240 11 kong kong NNP cord-266593-hmx2wy1p 240 12 Pandemic Pandemic NNP cord-266593-hmx2wy1p 240 13 ( ( -LRB- cord-266593-hmx2wy1p 240 14 h1n1 h1n1 NNP cord-266593-hmx2wy1p 240 15 ) ) -RRB- cord-266593-hmx2wy1p 241 1 2009 2009 CD cord-266593-hmx2wy1p 241 2 influenza influenza NN cord-266593-hmx2wy1p 241 3 in in IN cord-266593-hmx2wy1p 241 4 the the DT cord-266593-hmx2wy1p 241 5 UK UK NNP cord-266593-hmx2wy1p 241 6 : : : cord-266593-hmx2wy1p 241 7 clinical clinical JJ cord-266593-hmx2wy1p 241 8 and and CC cord-266593-hmx2wy1p 241 9 epidemiological epidemiological JJ cord-266593-hmx2wy1p 241 10 findings finding NNS cord-266593-hmx2wy1p 241 11 from from IN cord-266593-hmx2wy1p 241 12 the the DT cord-266593-hmx2wy1p 241 13 first first JJ cord-266593-hmx2wy1p 241 14 few few JJ cord-266593-hmx2wy1p 241 15 hundred hundred CD cord-266593-hmx2wy1p 241 16 ( ( -LRB- cord-266593-hmx2wy1p 241 17 FF100 FF100 NNP cord-266593-hmx2wy1p 241 18 ) ) -RRB- cord-266593-hmx2wy1p 241 19 cases case NNS cord-266593-hmx2wy1p 241 20 Interpretable interpretable JJ cord-266593-hmx2wy1p 241 21 machine machine NN cord-266593-hmx2wy1p 241 22 learning learn VBG cord-266593-hmx2wy1p 241 23 : : : cord-266593-hmx2wy1p 241 24 a a DT cord-266593-hmx2wy1p 241 25 guide guide NN cord-266593-hmx2wy1p 241 26 for for IN cord-266593-hmx2wy1p 241 27 making make VBG cord-266593-hmx2wy1p 241 28 black black JJ cord-266593-hmx2wy1p 241 29 box box NN cord-266593-hmx2wy1p 241 30 models model NNS cord-266593-hmx2wy1p 241 31 explainable explainable JJ cord-266593-hmx2wy1p 241 32 Does do VBZ cord-266593-hmx2wy1p 241 33 influenza influenza NN cord-266593-hmx2wy1p 241 34 transmission transmission NN cord-266593-hmx2wy1p 241 35 occur occur VBP cord-266593-hmx2wy1p 241 36 from from IN cord-266593-hmx2wy1p 241 37 asymptomatic asymptomatic JJ cord-266593-hmx2wy1p 241 38 infection infection NN cord-266593-hmx2wy1p 241 39 or or CC cord-266593-hmx2wy1p 241 40 prior prior RB cord-266593-hmx2wy1p 241 41 to to IN cord-266593-hmx2wy1p 241 42 symptom symptom NN cord-266593-hmx2wy1p 241 43 onset onset NN cord-266593-hmx2wy1p 241 44 ? ? . cord-266593-hmx2wy1p 242 1 Public Public NNP cord-266593-hmx2wy1p 242 2 Health Health NNP cord-266593-hmx2wy1p 242 3 Rep Rep NNP cord-266593-hmx2wy1p 242 4 Scikit Scikit NNP cord-266593-hmx2wy1p 242 5 - - HYPH cord-266593-hmx2wy1p 242 6 learn learn VB cord-266593-hmx2wy1p 242 7 : : : cord-266593-hmx2wy1p 242 8 machine machine NN cord-266593-hmx2wy1p 242 9 learning learn VBG cord-266593-hmx2wy1p 242 10 in in IN cord-266593-hmx2wy1p 242 11 python python NNP cord-266593-hmx2wy1p 242 12 Reliable Reliable NNP cord-266593-hmx2wy1p 242 13 ABC ABC NNP cord-266593-hmx2wy1p 242 14 model model NN cord-266593-hmx2wy1p 242 15 choice choice NN cord-266593-hmx2wy1p 242 16 via via IN cord-266593-hmx2wy1p 242 17 random random JJ cord-266593-hmx2wy1p 242 18 forests forest NNS cord-266593-hmx2wy1p 243 1 Theoretical theoretical JJ cord-266593-hmx2wy1p 243 2 comparison comparison NN cord-266593-hmx2wy1p 243 3 between between IN cord-266593-hmx2wy1p 243 4 the the DT cord-266593-hmx2wy1p 243 5 gini gini NNP cord-266593-hmx2wy1p 243 6 index index NN cord-266593-hmx2wy1p 243 7 and and CC cord-266593-hmx2wy1p 243 8 information information NN cord-266593-hmx2wy1p 243 9 gain gain NN cord-266593-hmx2wy1p 243 10 criteria criterion NNS cord-266593-hmx2wy1p 244 1 Lack lack NN cord-266593-hmx2wy1p 244 2 of of IN cord-266593-hmx2wy1p 244 3 confidence confidence NN cord-266593-hmx2wy1p 244 4 in in IN cord-266593-hmx2wy1p 244 5 approximate approximate JJ cord-266593-hmx2wy1p 244 6 Bayesian bayesian JJ cord-266593-hmx2wy1p 244 7 computation computation NN cord-266593-hmx2wy1p 244 8 model model NN cord-266593-hmx2wy1p 244 9 choice choice NN cord-266593-hmx2wy1p 245 1 Approximate Approximate NNP cord-266593-hmx2wy1p 245 2 Bayesian Bayesian NNP cord-266593-hmx2wy1p 245 3 Computation Computation NNP cord-266593-hmx2wy1p 245 4 : : : cord-266593-hmx2wy1p 246 1 A a DT cord-266593-hmx2wy1p 246 2 Survey Survey NNP cord-266593-hmx2wy1p 246 3 on on IN cord-266593-hmx2wy1p 246 4 Recent Recent NNP cord-266593-hmx2wy1p 246 5 Results Results NNPS cord-266593-hmx2wy1p 246 6 Calculation Calculation NNP cord-266593-hmx2wy1p 246 7 of of IN cord-266593-hmx2wy1p 246 8 disease disease NN cord-266593-hmx2wy1p 246 9 dynamics dynamic NNS cord-266593-hmx2wy1p 246 10 in in IN cord-266593-hmx2wy1p 246 11 a a DT cord-266593-hmx2wy1p 246 12 population population NN cord-266593-hmx2wy1p 246 13 of of IN cord-266593-hmx2wy1p 246 14 households household NNS cord-266593-hmx2wy1p 247 1 A a DT cord-266593-hmx2wy1p 247 2 review review NN cord-266593-hmx2wy1p 247 3 of of IN cord-266593-hmx2wy1p 247 4 modern modern JJ cord-266593-hmx2wy1p 247 5 computational computational JJ cord-266593-hmx2wy1p 247 6 algorithms algorithm NNS cord-266593-hmx2wy1p 247 7 for for IN cord-266593-hmx2wy1p 247 8 bayesian bayesian JJ cord-266593-hmx2wy1p 247 9 optimal optimal NNP cord-266593-hmx2wy1p 247 10 design design NN cord-266593-hmx2wy1p 247 11 Efficient efficient JJ cord-266593-hmx2wy1p 247 12 model model NN cord-266593-hmx2wy1p 247 13 comparison comparison NN cord-266593-hmx2wy1p 247 14 techniques technique NNS cord-266593-hmx2wy1p 247 15 for for IN cord-266593-hmx2wy1p 247 16 models model NNS cord-266593-hmx2wy1p 247 17 requiring require VBG cord-266593-hmx2wy1p 247 18 large large JJ cord-266593-hmx2wy1p 247 19 scale scale NN cord-266593-hmx2wy1p 247 20 data datum NNS cord-266593-hmx2wy1p 247 21 augmentation augmentation NN cord-266593-hmx2wy1p 247 22 Utility Utility NNP cord-266593-hmx2wy1p 247 23 of of IN cord-266593-hmx2wy1p 247 24 the the DT cord-266593-hmx2wy1p 247 25 first first JJ cord-266593-hmx2wy1p 247 26 few100 few100 NN cord-266593-hmx2wy1p 247 27 approach approach NN cord-266593-hmx2wy1p 247 28 during during IN cord-266593-hmx2wy1p 247 29 the the DT cord-266593-hmx2wy1p 247 30 2009 2009 CD cord-266593-hmx2wy1p 247 31 influenza influenza NN cord-266593-hmx2wy1p 247 32 a(h1n1 a(h1n1 NNP cord-266593-hmx2wy1p 247 33 ) ) -RRB- cord-266593-hmx2wy1p 247 34 pandemic pandemic NN cord-266593-hmx2wy1p 247 35 in in IN cord-266593-hmx2wy1p 247 36 the the DT cord-266593-hmx2wy1p 247 37 netherlands netherlands NNP cord-266593-hmx2wy1p 247 38 Inference Inference NNP cord-266593-hmx2wy1p 247 39 of of IN cord-266593-hmx2wy1p 247 40 epidemiological epidemiological JJ cord-266593-hmx2wy1p 247 41 parameters parameter NNS cord-266593-hmx2wy1p 247 42 from from IN cord-266593-hmx2wy1p 247 43 household household NN cord-266593-hmx2wy1p 247 44 stratified stratified JJ cord-266593-hmx2wy1p 247 45 data datum NNS cord-266593-hmx2wy1p 248 1 Linking link VBG cord-266593-hmx2wy1p 248 2 timevarying timevarye VBG cord-266593-hmx2wy1p 248 3 symptomatology symptomatology NN cord-266593-hmx2wy1p 248 4 and and CC cord-266593-hmx2wy1p 248 5 intensity intensity NN cord-266593-hmx2wy1p 248 6 of of IN cord-266593-hmx2wy1p 248 7 infectiousness infectiousness NN cord-266593-hmx2wy1p 248 8 to to IN cord-266593-hmx2wy1p 248 9 patterns pattern NNS cord-266593-hmx2wy1p 248 10 of of IN cord-266593-hmx2wy1p 248 11 norovirus norovirus NN cord-266593-hmx2wy1p 248 12 transmission transmission NN cord-266593-hmx2wy1p 248 13 Supplementary supplementary JJ cord-266593-hmx2wy1p 248 14 material material NN cord-266593-hmx2wy1p 248 15 associated associate VBN cord-266593-hmx2wy1p 248 16 with with IN cord-266593-hmx2wy1p 248 17 this this DT cord-266593-hmx2wy1p 248 18 article article NN cord-266593-hmx2wy1p 248 19 can can MD cord-266593-hmx2wy1p 248 20 be be VB cord-266593-hmx2wy1p 248 21 found find VBN cord-266593-hmx2wy1p 248 22 , , , cord-266593-hmx2wy1p 248 23 in in IN cord-266593-hmx2wy1p 248 24 the the DT cord-266593-hmx2wy1p 248 25 online online JJ cord-266593-hmx2wy1p 248 26 version version NN cord-266593-hmx2wy1p 248 27 , , , cord-266593-hmx2wy1p 248 28 at at IN cord-266593-hmx2wy1p 248 29 doi doi NN cord-266593-hmx2wy1p 248 30 : : : cord-266593-hmx2wy1p 248 31 10.1016 10.1016 CD cord-266593-hmx2wy1p 248 32 / / SYM cord-266593-hmx2wy1p 248 33 j.jtbi.2019.110079 j.jtbi.2019.110079 NN cord-266593-hmx2wy1p 248 34 . . .