id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-006588-aavpj5r3	Schwarte, L.A.	Mechanical ventilation of mice	2000		.txt	text/plain	5712	288	42	First, the ÒanesthesiologicalÓ indication: one of the major goals of anesthesia is achievement of more (39, 52) , mice lacking the brain derived neurotropic factor BDNF (1), RET-protooncogene deÞcient mice with depressed ventilatory response (4), and endothelin-1 deficient mice with altered blood gas-values (e.g., signiÞcantly lower PO 2 than wild type littermates) and impaired respiratory response to hypoxia and hypercapnia (30) . The most obvious difference between spontaneous respiration and usual modes of mechanical ventilation (MV) are inverted pressure relations, with respect to ambient pressure, during the respiratory cycle: during spontaneous inspiration the expansion of the intrathoracic volume (mainly caused by contraction of the diaphragm and extension of the rib cage) generates a negative intrathoracic pressure and allows gas ßow into the lungs. A typical example for a ventilator-induced regional side effect is the mechanical hyperinßation of the murine lung, e.g., when large tidal volumes or high airway pressures are applied.	./cache/cord-006588-aavpj5r3.txt	./txt/cord-006588-aavpj5r3.txt