id sid tid token lemma pos cord-258129-c38q6xxs 1 1 key key JJ cord-258129-c38q6xxs 2 1 : : : cord-258129-c38q6xxs 2 2 cord-258129-c38q6xxs cord-258129-c38q6xxs NN cord-258129-c38q6xxs 2 3 authors author NNS cord-258129-c38q6xxs 2 4 : : : cord-258129-c38q6xxs 2 5 Russell Russell NNP cord-258129-c38q6xxs 2 6 , , , cord-258129-c38q6xxs 2 7 Clark Clark NNP cord-258129-c38q6xxs 2 8 D D NNP cord-258129-c38q6xxs 2 9 ; ; : cord-258129-c38q6xxs 2 10 Schwarze Schwarze NNP cord-258129-c38q6xxs 2 11 , , , cord-258129-c38q6xxs 2 12 Jürgen Jürgen NNP cord-258129-c38q6xxs 2 13 title title NN cord-258129-c38q6xxs 2 14 : : : cord-258129-c38q6xxs 2 15 The the DT cord-258129-c38q6xxs 2 16 role role NN cord-258129-c38q6xxs 2 17 of of IN cord-258129-c38q6xxs 2 18 pro pro JJ cord-258129-c38q6xxs 2 19 - - JJ cord-258129-c38q6xxs 2 20 resolution resolution JJ cord-258129-c38q6xxs 2 21 lipid lipid NN cord-258129-c38q6xxs 2 22 mediators mediator NNS cord-258129-c38q6xxs 2 23 in in IN cord-258129-c38q6xxs 2 24 infectious infectious JJ cord-258129-c38q6xxs 2 25 disease disease NN cord-258129-c38q6xxs 2 26 date date NN cord-258129-c38q6xxs 2 27 : : : cord-258129-c38q6xxs 2 28 2014 2014 CD cord-258129-c38q6xxs 2 29 - - HYPH cord-258129-c38q6xxs 2 30 01 01 CD cord-258129-c38q6xxs 2 31 - - HYPH cord-258129-c38q6xxs 2 32 09 09 CD cord-258129-c38q6xxs 2 33 journal journal NN cord-258129-c38q6xxs 2 34 : : : cord-258129-c38q6xxs 3 1 Immunology Immunology NNP cord-258129-c38q6xxs 3 2 DOI DOI NNP cord-258129-c38q6xxs 3 3 : : : cord-258129-c38q6xxs 3 4 10.1111 10.1111 CD cord-258129-c38q6xxs 3 5 / / SYM cord-258129-c38q6xxs 3 6 imm.12206 imm.12206 NN cord-258129-c38q6xxs 4 1 sha sha NNP cord-258129-c38q6xxs 4 2 : : : cord-258129-c38q6xxs 4 3 7d7f10332fe3e37ee93b54d26dc0865ddf759a05 7d7f10332fe3e37ee93b54d26dc0865ddf759a05 CD cord-258129-c38q6xxs 4 4 doc_id doc_id CD cord-258129-c38q6xxs 4 5 : : : cord-258129-c38q6xxs 4 6 258129 258129 CD cord-258129-c38q6xxs 4 7 cord_uid cord_uid NNS cord-258129-c38q6xxs 4 8 : : : cord-258129-c38q6xxs 4 9 c38q6xxs c38q6xxs CD cord-258129-c38q6xxs 5 1 Inflammation inflammation NN cord-258129-c38q6xxs 5 2 is be VBZ cord-258129-c38q6xxs 5 3 an an DT cord-258129-c38q6xxs 5 4 essential essential JJ cord-258129-c38q6xxs 5 5 host host NN cord-258129-c38q6xxs 5 6 defence defence NN cord-258129-c38q6xxs 5 7 against against IN cord-258129-c38q6xxs 5 8 infection infection NN cord-258129-c38q6xxs 5 9 , , , cord-258129-c38q6xxs 5 10 but but CC cord-258129-c38q6xxs 5 11 can can MD cord-258129-c38q6xxs 5 12 be be VB cord-258129-c38q6xxs 5 13 damaging damaging JJ cord-258129-c38q6xxs 5 14 when when WRB cord-258129-c38q6xxs 5 15 excessive excessive JJ cord-258129-c38q6xxs 5 16 . . . cord-258129-c38q6xxs 6 1 Resolution resolution NN cord-258129-c38q6xxs 6 2 of of IN cord-258129-c38q6xxs 6 3 inflammation inflammation NN cord-258129-c38q6xxs 6 4 is be VBZ cord-258129-c38q6xxs 6 5 an an DT cord-258129-c38q6xxs 6 6 active active JJ cord-258129-c38q6xxs 6 7 process process NN cord-258129-c38q6xxs 6 8 , , , cord-258129-c38q6xxs 6 9 and and CC cord-258129-c38q6xxs 6 10 the the DT cord-258129-c38q6xxs 6 11 pro pro JJ cord-258129-c38q6xxs 6 12 - - JJ cord-258129-c38q6xxs 6 13 resolution resolution JJ cord-258129-c38q6xxs 6 14 effects effect NNS cord-258129-c38q6xxs 6 15 of of IN cord-258129-c38q6xxs 6 16 lipoxins lipoxin NNS cord-258129-c38q6xxs 6 17 , , , cord-258129-c38q6xxs 6 18 resolvins resolvins NNP cord-258129-c38q6xxs 6 19 and and CC cord-258129-c38q6xxs 6 20 protectins protectin NNS cord-258129-c38q6xxs 6 21 have have VBP cord-258129-c38q6xxs 6 22 received receive VBN cord-258129-c38q6xxs 6 23 significant significant JJ cord-258129-c38q6xxs 6 24 interest interest NN cord-258129-c38q6xxs 6 25 . . . cord-258129-c38q6xxs 7 1 Here here RB cord-258129-c38q6xxs 7 2 , , , cord-258129-c38q6xxs 7 3 we -PRON- PRP cord-258129-c38q6xxs 7 4 review review VBP cord-258129-c38q6xxs 7 5 emerging emerge VBG cord-258129-c38q6xxs 7 6 data datum NNS cord-258129-c38q6xxs 7 7 on on IN cord-258129-c38q6xxs 7 8 the the DT cord-258129-c38q6xxs 7 9 role role NN cord-258129-c38q6xxs 7 10 of of IN cord-258129-c38q6xxs 7 11 these these DT cord-258129-c38q6xxs 7 12 lipid lipid NN cord-258129-c38q6xxs 7 13 mediators mediator NNS cord-258129-c38q6xxs 7 14 in in IN cord-258129-c38q6xxs 7 15 infectious infectious JJ cord-258129-c38q6xxs 7 16 disease disease NN cord-258129-c38q6xxs 7 17 . . . cord-258129-c38q6xxs 8 1 Lipoxins Lipoxins NNP cord-258129-c38q6xxs 8 2 influence influence NN cord-258129-c38q6xxs 8 3 host host NN cord-258129-c38q6xxs 8 4 control control NN cord-258129-c38q6xxs 8 5 of of IN cord-258129-c38q6xxs 8 6 Mycobacterium Mycobacterium NNP cord-258129-c38q6xxs 8 7 tuberculosis tuberculosis NN cord-258129-c38q6xxs 8 8 , , , cord-258129-c38q6xxs 8 9 Toxoplasma toxoplasma NN cord-258129-c38q6xxs 8 10 gondii gondii NN cord-258129-c38q6xxs 8 11 , , , cord-258129-c38q6xxs 8 12 Trypanosoma Trypanosoma NNP cord-258129-c38q6xxs 8 13 cruzi cruzi NNP cord-258129-c38q6xxs 8 14 and and CC cord-258129-c38q6xxs 8 15 Plasmodium Plasmodium NNP cord-258129-c38q6xxs 8 16 berghei berghei JJ cord-258129-c38q6xxs 8 17 cerebral cerebral JJ cord-258129-c38q6xxs 8 18 malaria malaria NN cord-258129-c38q6xxs 8 19 in in IN cord-258129-c38q6xxs 8 20 mice mouse NNS cord-258129-c38q6xxs 8 21 . . . cord-258129-c38q6xxs 9 1 Their -PRON- PRP$ cord-258129-c38q6xxs 9 2 effects effect NNS cord-258129-c38q6xxs 9 3 are be VBP cord-258129-c38q6xxs 9 4 protective protective JJ cord-258129-c38q6xxs 9 5 in in IN cord-258129-c38q6xxs 9 6 toxoplasmosis toxoplasmosis NN cord-258129-c38q6xxs 9 7 , , , cord-258129-c38q6xxs 9 8 T. T. NNP cord-258129-c38q6xxs 9 9 cruzi cruzi NN cord-258129-c38q6xxs 9 10 infection infection NN cord-258129-c38q6xxs 9 11 and and CC cord-258129-c38q6xxs 9 12 cerebral cerebral JJ cord-258129-c38q6xxs 9 13 malaria malaria NN cord-258129-c38q6xxs 9 14 but but CC cord-258129-c38q6xxs 9 15 detrimental detrimental JJ cord-258129-c38q6xxs 9 16 in in IN cord-258129-c38q6xxs 9 17 tuberculosis tuberculosis NN cord-258129-c38q6xxs 9 18 ; ; , cord-258129-c38q6xxs 9 19 related relate VBN cord-258129-c38q6xxs 9 20 to to IN cord-258129-c38q6xxs 9 21 the the DT cord-258129-c38q6xxs 9 22 balance balance NN cord-258129-c38q6xxs 9 23 between between IN cord-258129-c38q6xxs 9 24 pathogen pathogen NN cord-258129-c38q6xxs 9 25 - - HYPH cord-258129-c38q6xxs 9 26 control control NN cord-258129-c38q6xxs 9 27 and and CC cord-258129-c38q6xxs 9 28 excessive excessive JJ cord-258129-c38q6xxs 9 29 immune immune JJ cord-258129-c38q6xxs 9 30 response response NN cord-258129-c38q6xxs 9 31 . . . cord-258129-c38q6xxs 10 1 Topical topical JJ cord-258129-c38q6xxs 10 2 lipoxin lipoxin NN cord-258129-c38q6xxs 10 3 abrogates abrogate VBZ cord-258129-c38q6xxs 10 4 the the DT cord-258129-c38q6xxs 10 5 tissue tissue NN cord-258129-c38q6xxs 10 6 damage damage NN cord-258129-c38q6xxs 10 7 seen see VBN cord-258129-c38q6xxs 10 8 in in IN cord-258129-c38q6xxs 10 9 a a DT cord-258129-c38q6xxs 10 10 rabbit rabbit NN cord-258129-c38q6xxs 10 11 model model NN cord-258129-c38q6xxs 10 12 of of IN cord-258129-c38q6xxs 10 13 Porphyromonas Porphyromonas NNP cord-258129-c38q6xxs 10 14 gingivalis gingivalis NNP cord-258129-c38q6xxs 10 15 periodontitis periodontitis NN cord-258129-c38q6xxs 10 16 . . . cord-258129-c38q6xxs 11 1 The the DT cord-258129-c38q6xxs 11 2 increased increase VBN cord-258129-c38q6xxs 11 3 virulence virulence NN cord-258129-c38q6xxs 11 4 of of IN cord-258129-c38q6xxs 11 5 H5N1 H5N1 NNP cord-258129-c38q6xxs 11 6 influenza influenza NN cord-258129-c38q6xxs 11 7 A a DT cord-258129-c38q6xxs 11 8 virus virus NN cord-258129-c38q6xxs 11 9 in in IN cord-258129-c38q6xxs 11 10 mice mouse NNS cord-258129-c38q6xxs 11 11 correlates correlate VBZ cord-258129-c38q6xxs 11 12 with with IN cord-258129-c38q6xxs 11 13 reduced reduce VBN cord-258129-c38q6xxs 11 14 expression expression NN cord-258129-c38q6xxs 11 15 of of IN cord-258129-c38q6xxs 11 16 SOCS2 socs2 NN cord-258129-c38q6xxs 11 17 , , , cord-258129-c38q6xxs 11 18 required require VBN cord-258129-c38q6xxs 11 19 to to TO cord-258129-c38q6xxs 11 20 mediate mediate VB cord-258129-c38q6xxs 11 21 the the DT cord-258129-c38q6xxs 11 22 effects effect NNS cord-258129-c38q6xxs 11 23 of of IN cord-258129-c38q6xxs 11 24 lipoxin lipoxin NNP cord-258129-c38q6xxs 11 25 . . . cord-258129-c38q6xxs 12 1 Mice mouse NNS cord-258129-c38q6xxs 12 2 unable unable JJ cord-258129-c38q6xxs 12 3 to to TO cord-258129-c38q6xxs 12 4 synthesize synthesize VB cord-258129-c38q6xxs 12 5 lipoxin lipoxin NNP cord-258129-c38q6xxs 12 6 suffer suffer VB cord-258129-c38q6xxs 12 7 increased increase VBN cord-258129-c38q6xxs 12 8 lung lung NN cord-258129-c38q6xxs 12 9 pathology pathology NN cord-258129-c38q6xxs 12 10 during during IN cord-258129-c38q6xxs 12 11 respiratory respiratory JJ cord-258129-c38q6xxs 12 12 syncytial syncytial JJ cord-258129-c38q6xxs 12 13 virus virus NN cord-258129-c38q6xxs 12 14 infection infection NN cord-258129-c38q6xxs 12 15 . . . cord-258129-c38q6xxs 13 1 Protectin Protectin NNP cord-258129-c38q6xxs 13 2 suppresses suppress VBZ cord-258129-c38q6xxs 13 3 influenza influenza NN cord-258129-c38q6xxs 13 4 A a DT cord-258129-c38q6xxs 13 5 virus virus NN cord-258129-c38q6xxs 13 6 replication replication NN cord-258129-c38q6xxs 13 7 in in IN cord-258129-c38q6xxs 13 8 vitro vitro FW cord-258129-c38q6xxs 13 9 and and CC cord-258129-c38q6xxs 13 10 increases increase VBZ cord-258129-c38q6xxs 13 11 survival survival NN cord-258129-c38q6xxs 13 12 in in IN cord-258129-c38q6xxs 13 13 a a DT cord-258129-c38q6xxs 13 14 mouse mouse NN cord-258129-c38q6xxs 13 15 model model NN cord-258129-c38q6xxs 13 16 of of IN cord-258129-c38q6xxs 13 17 severe severe JJ cord-258129-c38q6xxs 13 18 influenza influenza NN cord-258129-c38q6xxs 13 19 infection infection NN cord-258129-c38q6xxs 13 20 . . . cord-258129-c38q6xxs 14 1 Resolvins Resolvins NNP cord-258129-c38q6xxs 14 2 were be VBD cord-258129-c38q6xxs 14 3 investigated investigate VBN cord-258129-c38q6xxs 14 4 in in IN cord-258129-c38q6xxs 14 5 a a DT cord-258129-c38q6xxs 14 6 number number NN cord-258129-c38q6xxs 14 7 of of IN cord-258129-c38q6xxs 14 8 animal animal NN cord-258129-c38q6xxs 14 9 models model NNS cord-258129-c38q6xxs 14 10 of of IN cord-258129-c38q6xxs 14 11 systemic systemic JJ cord-258129-c38q6xxs 14 12 bacterial bacterial JJ cord-258129-c38q6xxs 14 13 infection infection NN cord-258129-c38q6xxs 14 14 , , , cord-258129-c38q6xxs 14 15 and and CC cord-258129-c38q6xxs 14 16 were be VBD cord-258129-c38q6xxs 14 17 found find VBN cord-258129-c38q6xxs 14 18 to to TO cord-258129-c38q6xxs 14 19 enhance enhance VB cord-258129-c38q6xxs 14 20 phagocytic phagocytic JJ cord-258129-c38q6xxs 14 21 clearance clearance NN cord-258129-c38q6xxs 14 22 of of IN cord-258129-c38q6xxs 14 23 bacteria bacteria NNS cord-258129-c38q6xxs 14 24 , , , cord-258129-c38q6xxs 14 25 reduce reduce VB cord-258129-c38q6xxs 14 26 inflammation inflammation NN cord-258129-c38q6xxs 14 27 severity severity NN cord-258129-c38q6xxs 14 28 , , , cord-258129-c38q6xxs 14 29 promote promote VB cord-258129-c38q6xxs 14 30 neutrophil neutrophil NN cord-258129-c38q6xxs 14 31 apoptosis apoptosis NN cord-258129-c38q6xxs 14 32 , , , cord-258129-c38q6xxs 14 33 modulate modulate VB cord-258129-c38q6xxs 14 34 neutrophil neutrophil NN cord-258129-c38q6xxs 14 35 chemotaxis chemotaxis NN cord-258129-c38q6xxs 14 36 and and CC cord-258129-c38q6xxs 14 37 importantly importantly RB cord-258129-c38q6xxs 14 38 , , , cord-258129-c38q6xxs 14 39 reduce reduce VB cord-258129-c38q6xxs 14 40 mortality mortality NN cord-258129-c38q6xxs 14 41 . . . cord-258129-c38q6xxs 15 1 Interestingly interestingly RB cord-258129-c38q6xxs 15 2 , , , cord-258129-c38q6xxs 15 3 resolvin resolvin NNP cord-258129-c38q6xxs 15 4 also also RB cord-258129-c38q6xxs 15 5 enhances enhance VBZ cord-258129-c38q6xxs 15 6 the the DT cord-258129-c38q6xxs 15 7 antibacterial antibacterial JJ cord-258129-c38q6xxs 15 8 effect effect NN cord-258129-c38q6xxs 15 9 of of IN cord-258129-c38q6xxs 15 10 ciprofloxacin ciprofloxacin NN cord-258129-c38q6xxs 15 11 and and CC cord-258129-c38q6xxs 15 12 vancomycin vancomycin NN cord-258129-c38q6xxs 15 13 . . . cord-258129-c38q6xxs 16 1 Topical topical JJ cord-258129-c38q6xxs 16 2 resolvin resolvin NN cord-258129-c38q6xxs 16 3 application application NN cord-258129-c38q6xxs 16 4 reduces reduce VBZ cord-258129-c38q6xxs 16 5 the the DT cord-258129-c38q6xxs 16 6 severity severity NN cord-258129-c38q6xxs 16 7 of of IN cord-258129-c38q6xxs 16 8 herpes herpes NNP cord-258129-c38q6xxs 16 9 simplex simplex NNP cord-258129-c38q6xxs 16 10 virus virus NN cord-258129-c38q6xxs 16 11 ocular ocular JJ cord-258129-c38q6xxs 16 12 infection infection NN cord-258129-c38q6xxs 16 13 in in IN cord-258129-c38q6xxs 16 14 mice mouse NNS cord-258129-c38q6xxs 16 15 . . . cord-258129-c38q6xxs 17 1 If if IN cord-258129-c38q6xxs 17 2 the the DT cord-258129-c38q6xxs 17 3 effects effect NNS cord-258129-c38q6xxs 17 4 of of IN cord-258129-c38q6xxs 17 5 these these DT cord-258129-c38q6xxs 17 6 mediators mediator NNS cord-258129-c38q6xxs 17 7 translate translate VBP cord-258129-c38q6xxs 17 8 from from IN cord-258129-c38q6xxs 17 9 pre pre JJ cord-258129-c38q6xxs 17 10 - - JJ cord-258129-c38q6xxs 17 11 clinical clinical JJ cord-258129-c38q6xxs 17 12 studies study NNS cord-258129-c38q6xxs 17 13 into into IN cord-258129-c38q6xxs 17 14 successful successful JJ cord-258129-c38q6xxs 17 15 clinical clinical JJ cord-258129-c38q6xxs 17 16 trials trial NNS cord-258129-c38q6xxs 17 17 , , , cord-258129-c38q6xxs 17 18 they -PRON- PRP cord-258129-c38q6xxs 17 19 represent represent VBP cord-258129-c38q6xxs 17 20 promising promising JJ cord-258129-c38q6xxs 17 21 new new JJ cord-258129-c38q6xxs 17 22 strategies strategy NNS cord-258129-c38q6xxs 17 23 in in IN cord-258129-c38q6xxs 17 24 managing manage VBG cord-258129-c38q6xxs 17 25 infectious infectious JJ cord-258129-c38q6xxs 17 26 disease disease NN cord-258129-c38q6xxs 17 27 . . . cord-258129-c38q6xxs 18 1 Inflammation inflammation NN cord-258129-c38q6xxs 18 2 is be VBZ cord-258129-c38q6xxs 18 3 an an DT cord-258129-c38q6xxs 18 4 essential essential JJ cord-258129-c38q6xxs 18 5 host host NN cord-258129-c38q6xxs 18 6 defence defence NN cord-258129-c38q6xxs 18 7 mechanism mechanism NN cord-258129-c38q6xxs 18 8 , , , cord-258129-c38q6xxs 18 9 required require VBN cord-258129-c38q6xxs 18 10 for for IN cord-258129-c38q6xxs 18 11 protection protection NN cord-258129-c38q6xxs 18 12 against against IN cord-258129-c38q6xxs 18 13 pathogenic pathogenic JJ cord-258129-c38q6xxs 18 14 micro micro NNS cord-258129-c38q6xxs 18 15 - - HYPH cord-258129-c38q6xxs 18 16 organisms organism NNS cord-258129-c38q6xxs 18 17 and and CC cord-258129-c38q6xxs 18 18 viruses virus NNS cord-258129-c38q6xxs 18 19 . . . cord-258129-c38q6xxs 19 1 However however RB cord-258129-c38q6xxs 19 2 , , , cord-258129-c38q6xxs 19 3 an an DT cord-258129-c38q6xxs 19 4 excessive excessive JJ cord-258129-c38q6xxs 19 5 and and CC cord-258129-c38q6xxs 19 6 non non JJ cord-258129-c38q6xxs 19 7 - - JJ cord-258129-c38q6xxs 19 8 resolving resolve VBG cord-258129-c38q6xxs 19 9 inflammatory inflammatory JJ cord-258129-c38q6xxs 19 10 response response NN cord-258129-c38q6xxs 19 11 is be VBZ cord-258129-c38q6xxs 19 12 damaging damaging JJ cord-258129-c38q6xxs 19 13 to to IN cord-258129-c38q6xxs 19 14 the the DT cord-258129-c38q6xxs 19 15 host host NN cord-258129-c38q6xxs 19 16 . . . cord-258129-c38q6xxs 20 1 For for IN cord-258129-c38q6xxs 20 2 example example NN cord-258129-c38q6xxs 20 3 , , , cord-258129-c38q6xxs 20 4 in in IN cord-258129-c38q6xxs 20 5 sepsis sepsis NN cord-258129-c38q6xxs 20 6 there there EX cord-258129-c38q6xxs 20 7 is be VBZ cord-258129-c38q6xxs 20 8 loss loss NN cord-258129-c38q6xxs 20 9 of of IN cord-258129-c38q6xxs 20 10 homeostatic homeostatic JJ cord-258129-c38q6xxs 20 11 control control NN cord-258129-c38q6xxs 20 12 over over IN cord-258129-c38q6xxs 20 13 the the DT cord-258129-c38q6xxs 20 14 inflammatory inflammatory JJ cord-258129-c38q6xxs 20 15 response response NN cord-258129-c38q6xxs 20 16 mounted mount VBD cord-258129-c38q6xxs 20 17 against against IN cord-258129-c38q6xxs 20 18 an an DT cord-258129-c38q6xxs 20 19 infectious infectious JJ cord-258129-c38q6xxs 20 20 agent agent NN cord-258129-c38q6xxs 20 21 , , , cord-258129-c38q6xxs 20 22 resulting result VBG cord-258129-c38q6xxs 20 23 in in IN cord-258129-c38q6xxs 20 24 a a DT cord-258129-c38q6xxs 20 25 pro pro JJ cord-258129-c38q6xxs 20 26 - - JJ cord-258129-c38q6xxs 20 27 inflammatory inflammatory JJ cord-258129-c38q6xxs 20 28 , , , cord-258129-c38q6xxs 20 29 procoagulant procoagulant NN cord-258129-c38q6xxs 20 30 state state NN cord-258129-c38q6xxs 20 31 that that WDT cord-258129-c38q6xxs 20 32 can can MD cord-258129-c38q6xxs 20 33 result result VB cord-258129-c38q6xxs 20 34 in in IN cord-258129-c38q6xxs 20 35 organ organ NN cord-258129-c38q6xxs 20 36 dysfunction dysfunction NN cord-258129-c38q6xxs 20 37 and and CC cord-258129-c38q6xxs 20 38 death death NN cord-258129-c38q6xxs 20 39 . . . cord-258129-c38q6xxs 21 1 Acute acute JJ cord-258129-c38q6xxs 21 2 respiratory respiratory JJ cord-258129-c38q6xxs 21 3 distress distress NN cord-258129-c38q6xxs 21 4 syndrome syndrome NN cord-258129-c38q6xxs 21 5 is be VBZ cord-258129-c38q6xxs 21 6 another another DT cord-258129-c38q6xxs 21 7 example example NN cord-258129-c38q6xxs 21 8 , , , cord-258129-c38q6xxs 21 9 and and CC cord-258129-c38q6xxs 21 10 describes describe VBZ cord-258129-c38q6xxs 21 11 the the DT cord-258129-c38q6xxs 21 12 life life NN cord-258129-c38q6xxs 21 13 - - HYPH cord-258129-c38q6xxs 21 14 threatening threaten VBG cord-258129-c38q6xxs 21 15 hypoxic hypoxic JJ cord-258129-c38q6xxs 21 16 complication complication NN cord-258129-c38q6xxs 21 17 of of IN cord-258129-c38q6xxs 21 18 excessive excessive JJ cord-258129-c38q6xxs 21 19 pulmonary pulmonary JJ cord-258129-c38q6xxs 21 20 inflammation inflammation NN cord-258129-c38q6xxs 21 21 that that WDT cord-258129-c38q6xxs 21 22 can can MD cord-258129-c38q6xxs 21 23 be be VB cord-258129-c38q6xxs 21 24 triggered trigger VBN cord-258129-c38q6xxs 21 25 by by IN cord-258129-c38q6xxs 21 26 a a DT cord-258129-c38q6xxs 21 27 range range NN cord-258129-c38q6xxs 21 28 of of IN cord-258129-c38q6xxs 21 29 insults insult NNS cord-258129-c38q6xxs 21 30 , , , cord-258129-c38q6xxs 21 31 including include VBG cord-258129-c38q6xxs 21 32 pneumonia pneumonia NN cord-258129-c38q6xxs 21 33 and and CC cord-258129-c38q6xxs 21 34 sepsis sepsis NN cord-258129-c38q6xxs 21 35 . . . cord-258129-c38q6xxs 22 1 1 1 LS cord-258129-c38q6xxs 22 2 Chronic Chronic NNP cord-258129-c38q6xxs 22 3 , , , cord-258129-c38q6xxs 22 4 non non JJ cord-258129-c38q6xxs 22 5 - - JJ cord-258129-c38q6xxs 22 6 resolving resolve VBG cord-258129-c38q6xxs 22 7 inflammation inflammation NN cord-258129-c38q6xxs 22 8 also also RB cord-258129-c38q6xxs 22 9 underpins underpin VBZ cord-258129-c38q6xxs 22 10 a a DT cord-258129-c38q6xxs 22 11 number number NN cord-258129-c38q6xxs 22 12 of of IN cord-258129-c38q6xxs 22 13 other other JJ cord-258129-c38q6xxs 22 14 pulmonary pulmonary JJ cord-258129-c38q6xxs 22 15 diseases disease NNS cord-258129-c38q6xxs 22 16 , , , cord-258129-c38q6xxs 22 17 including include VBG cord-258129-c38q6xxs 22 18 asthma asthma NN cord-258129-c38q6xxs 22 19 , , , cord-258129-c38q6xxs 22 20 cystic cystic JJ cord-258129-c38q6xxs 22 21 fibrosis fibrosis NN cord-258129-c38q6xxs 22 22 and and CC cord-258129-c38q6xxs 22 23 bronchiectasis bronchiectasis NN cord-258129-c38q6xxs 22 24 . . . cord-258129-c38q6xxs 23 1 Inflamma Inflamma NNP cord-258129-c38q6xxs 23 2 critical critical JJ cord-258129-c38q6xxs 23 3 events event NNS cord-258129-c38q6xxs 23 4 following follow VBG cord-258129-c38q6xxs 23 5 the the DT cord-258129-c38q6xxs 23 6 clearance clearance NN cord-258129-c38q6xxs 23 7 of of IN cord-258129-c38q6xxs 23 8 an an DT cord-258129-c38q6xxs 23 9 infectious infectious JJ cord-258129-c38q6xxs 23 10 agent agent NN cord-258129-c38q6xxs 23 11 , , , cord-258129-c38q6xxs 23 12 to to TO cord-258129-c38q6xxs 23 13 prevent prevent VB cord-258129-c38q6xxs 23 14 the the DT cord-258129-c38q6xxs 23 15 development development NN cord-258129-c38q6xxs 23 16 of of IN cord-258129-c38q6xxs 23 17 these these DT cord-258129-c38q6xxs 23 18 ' ' `` cord-258129-c38q6xxs 23 19 complications complication NNS cord-258129-c38q6xxs 23 20 ' ' POS cord-258129-c38q6xxs 23 21 of of IN cord-258129-c38q6xxs 23 22 excessive excessive JJ cord-258129-c38q6xxs 23 23 inflammation inflammation NN cord-258129-c38q6xxs 23 24 . . . cord-258129-c38q6xxs 24 1 This this DT cord-258129-c38q6xxs 24 2 is be VBZ cord-258129-c38q6xxs 24 3 now now RB cord-258129-c38q6xxs 24 4 known know VBN cord-258129-c38q6xxs 24 5 to to TO cord-258129-c38q6xxs 24 6 be be VB cord-258129-c38q6xxs 24 7 an an DT cord-258129-c38q6xxs 24 8 active active JJ cord-258129-c38q6xxs 24 9 process process NN cord-258129-c38q6xxs 24 10 , , , cord-258129-c38q6xxs 24 11 termed term VBN cord-258129-c38q6xxs 24 12 catabasis catabasis NN cord-258129-c38q6xxs 24 13 , , , cord-258129-c38q6xxs 24 14 2 2 CD cord-258129-c38q6xxs 24 15 driven drive VBN cord-258129-c38q6xxs 24 16 by by IN cord-258129-c38q6xxs 24 17 the the DT cord-258129-c38q6xxs 24 18 pro pro JJ cord-258129-c38q6xxs 24 19 - - JJ cord-258129-c38q6xxs 24 20 resolution resolution JJ cord-258129-c38q6xxs 24 21 lipid lipid NN cord-258129-c38q6xxs 24 22 mediators mediator NNS cord-258129-c38q6xxs 24 23 resolvin resolvin NNP cord-258129-c38q6xxs 24 24 , , , cord-258129-c38q6xxs 24 25 protectin protectin NNP cord-258129-c38q6xxs 24 26 and and CC cord-258129-c38q6xxs 24 27 lipoxin lipoxin NNP cord-258129-c38q6xxs 24 28 . . . cord-258129-c38q6xxs 25 1 3 3 LS cord-258129-c38q6xxs 25 2 Lipoxins Lipoxins NNP cord-258129-c38q6xxs 25 3 ( ( -LRB- cord-258129-c38q6xxs 25 4 trihydroxy trihydroxy JJ cord-258129-c38q6xxs 25 5 - - HYPH cord-258129-c38q6xxs 25 6 tetraene tetraene NN cord-258129-c38q6xxs 25 7 - - HYPH cord-258129-c38q6xxs 25 8 containing contain VBG cord-258129-c38q6xxs 25 9 eicosanoids eicosanoid NNS cord-258129-c38q6xxs 25 10 ) ) -RRB- cord-258129-c38q6xxs 25 11 are be VBP cord-258129-c38q6xxs 25 12 derived derive VBN cord-258129-c38q6xxs 25 13 from from IN cord-258129-c38q6xxs 25 14 the the DT cord-258129-c38q6xxs 25 15 omega-6 omega-6 JJ cord-258129-c38q6xxs 25 16 polyunsaturated polyunsaturated JJ cord-258129-c38q6xxs 25 17 fatty fatty JJ cord-258129-c38q6xxs 25 18 acid acid NN cord-258129-c38q6xxs 25 19 arachidonic arachidonic NN cord-258129-c38q6xxs 25 20 acid acid NN cord-258129-c38q6xxs 25 21 through through IN cord-258129-c38q6xxs 25 22 sequential sequential JJ cord-258129-c38q6xxs 25 23 reactions reaction NNS cord-258129-c38q6xxs 25 24 involving involve VBG cord-258129-c38q6xxs 25 25 lipoxygenase lipoxygenase NN cord-258129-c38q6xxs 25 26 enzymes enzyme NNS cord-258129-c38q6xxs 25 27 ( ( -LRB- cord-258129-c38q6xxs 25 28 including include VBG cord-258129-c38q6xxs 25 29 15-lipoxygenase 15-lipoxygenase CD cord-258129-c38q6xxs 25 30 type type NN cord-258129-c38q6xxs 25 31 1 1 CD cord-258129-c38q6xxs 25 32 and and CC cord-258129-c38q6xxs 25 33 5-lipoxygenase 5-lipoxygenase CD cord-258129-c38q6xxs 25 34 in in IN cord-258129-c38q6xxs 25 35 human human JJ cord-258129-c38q6xxs 25 36 mucosal mucosal JJ cord-258129-c38q6xxs 25 37 tissues tissue NNS cord-258129-c38q6xxs 25 38 ) ) -RRB- cord-258129-c38q6xxs 25 39 . . . cord-258129-c38q6xxs 26 1 4 4 LS cord-258129-c38q6xxs 26 2 , , , cord-258129-c38q6xxs 26 3 5 5 CD cord-258129-c38q6xxs 26 4 Resolvins resolvin NNS cord-258129-c38q6xxs 26 5 are be VBP cord-258129-c38q6xxs 26 6 derived derive VBN cord-258129-c38q6xxs 26 7 from from IN cord-258129-c38q6xxs 26 8 omega-3 omega-3 JJ cord-258129-c38q6xxs 26 9 polyunsaturated polyunsaturated JJ cord-258129-c38q6xxs 26 10 fatty fatty JJ cord-258129-c38q6xxs 26 11 acids acid NNS cord-258129-c38q6xxs 26 12 and and CC cord-258129-c38q6xxs 26 13 exist exist VBP cord-258129-c38q6xxs 26 14 as as IN cord-258129-c38q6xxs 26 15 two two CD cord-258129-c38q6xxs 26 16 series series NN cord-258129-c38q6xxs 26 17 ( ( -LRB- cord-258129-c38q6xxs 26 18 D D NNP cord-258129-c38q6xxs 26 19 and and CC cord-258129-c38q6xxs 26 20 E E NNP cord-258129-c38q6xxs 26 21 ) ) -RRB- cord-258129-c38q6xxs 26 22 . . . cord-258129-c38q6xxs 27 1 D D NNP cord-258129-c38q6xxs 27 2 - - HYPH cord-258129-c38q6xxs 27 3 series series NN cord-258129-c38q6xxs 27 4 resolvins resolvin NNS cord-258129-c38q6xxs 27 5 are be VBP cord-258129-c38q6xxs 27 6 products product NNS cord-258129-c38q6xxs 27 7 of of IN cord-258129-c38q6xxs 27 8 docosahexaenoic docosahexaenoic NNP cord-258129-c38q6xxs 27 9 acid acid NNP cord-258129-c38q6xxs 27 10 metabolism metabolism NN cord-258129-c38q6xxs 27 11 involving involve VBG cord-258129-c38q6xxs 27 12 15-lipoxygenase 15-lipoxygenase CD cord-258129-c38q6xxs 27 13 . . . cord-258129-c38q6xxs 28 1 E E NNP cord-258129-c38q6xxs 28 2 - - HYPH cord-258129-c38q6xxs 28 3 series series JJ cord-258129-c38q6xxs 28 4 resolvins resolvin NNS cord-258129-c38q6xxs 28 5 are be VBP cord-258129-c38q6xxs 28 6 synthesized synthesize VBN cord-258129-c38q6xxs 28 7 from from IN cord-258129-c38q6xxs 28 8 eicosapentaenoic eicosapentaenoic JJ cord-258129-c38q6xxs 28 9 acid acid NN cord-258129-c38q6xxs 28 10 involving involve VBG cord-258129-c38q6xxs 28 11 aspirin aspirin NN cord-258129-c38q6xxs 28 12 - - HYPH cord-258129-c38q6xxs 28 13 acetylated acetylate VBN cord-258129-c38q6xxs 28 14 cyclo cyclo NN cord-258129-c38q6xxs 28 15 - - HYPH cord-258129-c38q6xxs 28 16 oxygenase oxygenase JJ cord-258129-c38q6xxs 28 17 2 2 CD cord-258129-c38q6xxs 28 18 . . . cord-258129-c38q6xxs 29 1 6 6 CD cord-258129-c38q6xxs 29 2 Protectins protectin NNS cord-258129-c38q6xxs 29 3 are be VBP cord-258129-c38q6xxs 29 4 also also RB cord-258129-c38q6xxs 29 5 omega-3 omega-3 VBG cord-258129-c38q6xxs 29 6 polyunsaturated polyunsaturated JJ cord-258129-c38q6xxs 29 7 fatty fatty JJ cord-258129-c38q6xxs 29 8 acid acid NN cord-258129-c38q6xxs 29 9 derivatives derivative NNS cord-258129-c38q6xxs 29 10 , , , cord-258129-c38q6xxs 29 11 generated generate VBN cord-258129-c38q6xxs 29 12 from from IN cord-258129-c38q6xxs 29 13 docosahexaenoic docosahexaenoic NNP cord-258129-c38q6xxs 29 14 acid acid NNP cord-258129-c38q6xxs 29 15 through through IN cord-258129-c38q6xxs 29 16 a a DT cord-258129-c38q6xxs 29 17 15-lipoxygenase 15-lipoxygenase CD cord-258129-c38q6xxs 29 18 - - HYPH cord-258129-c38q6xxs 29 19 mediated mediate VBN cord-258129-c38q6xxs 29 20 pathway pathway NN cord-258129-c38q6xxs 29 21 . . . cord-258129-c38q6xxs 30 1 7 7 CD cord-258129-c38q6xxs 31 1 The the DT cord-258129-c38q6xxs 31 2 pro pro JJ cord-258129-c38q6xxs 31 3 - - JJ cord-258129-c38q6xxs 31 4 resolution resolution JJ cord-258129-c38q6xxs 31 5 effects effect NNS cord-258129-c38q6xxs 31 6 of of IN cord-258129-c38q6xxs 31 7 these these DT cord-258129-c38q6xxs 31 8 mediators mediator NNS cord-258129-c38q6xxs 31 9 are be VBP cord-258129-c38q6xxs 31 10 exemplified exemplify VBN cord-258129-c38q6xxs 31 11 by by IN cord-258129-c38q6xxs 31 12 their -PRON- PRP$ cord-258129-c38q6xxs 31 13 role role NN cord-258129-c38q6xxs 31 14 in in IN cord-258129-c38q6xxs 31 15 pulmonary pulmonary JJ cord-258129-c38q6xxs 31 16 inflammation inflammation NN cord-258129-c38q6xxs 31 17 , , , cord-258129-c38q6xxs 31 18 the the DT cord-258129-c38q6xxs 31 19 setting setting NN cord-258129-c38q6xxs 31 20 in in IN cord-258129-c38q6xxs 31 21 which which WDT cord-258129-c38q6xxs 31 22 they -PRON- PRP cord-258129-c38q6xxs 31 23 are be VBP cord-258129-c38q6xxs 31 24 best well RBS cord-258129-c38q6xxs 31 25 studied study VBN cord-258129-c38q6xxs 31 26 . . . cord-258129-c38q6xxs 32 1 Resolvins Resolvins NNP cord-258129-c38q6xxs 32 2 , , , cord-258129-c38q6xxs 32 3 protectins protectin NNS cord-258129-c38q6xxs 32 4 and and CC cord-258129-c38q6xxs 32 5 lipoxins lipoxin NNS cord-258129-c38q6xxs 32 6 all all DT cord-258129-c38q6xxs 32 7 have have VBP cord-258129-c38q6xxs 32 8 a a DT cord-258129-c38q6xxs 32 9 proresolution proresolution NN cord-258129-c38q6xxs 32 10 role role NN cord-258129-c38q6xxs 32 11 in in IN cord-258129-c38q6xxs 32 12 a a DT cord-258129-c38q6xxs 32 13 mouse mouse NN cord-258129-c38q6xxs 32 14 model model NN cord-258129-c38q6xxs 32 15 of of IN cord-258129-c38q6xxs 32 16 allergic allergic JJ cord-258129-c38q6xxs 32 17 airway airway NN cord-258129-c38q6xxs 32 18 inflammation inflammation NN cord-258129-c38q6xxs 32 19 . . . cord-258129-c38q6xxs 33 1 [ [ -LRB- cord-258129-c38q6xxs 33 2 8 8 CD cord-258129-c38q6xxs 33 3 ] ] -RRB- cord-258129-c38q6xxs 33 4 [ [ -LRB- cord-258129-c38q6xxs 33 5 9 9 CD cord-258129-c38q6xxs 33 6 ] ] -RRB- cord-258129-c38q6xxs 33 7 [ [ -LRB- cord-258129-c38q6xxs 33 8 10 10 CD cord-258129-c38q6xxs 33 9 ] ] -RRB- cord-258129-c38q6xxs 34 1 [ [ -LRB- cord-258129-c38q6xxs 34 2 11 11 CD cord-258129-c38q6xxs 34 3 ] ] -RRB- cord-258129-c38q6xxs 35 1 Given give VBN cord-258129-c38q6xxs 35 2 that that IN cord-258129-c38q6xxs 35 3 an an DT cord-258129-c38q6xxs 35 4 excessive excessive JJ cord-258129-c38q6xxs 35 5 inflammatory inflammatory JJ cord-258129-c38q6xxs 35 6 response response NN cord-258129-c38q6xxs 35 7 is be VBZ cord-258129-c38q6xxs 35 8 implicated implicate VBN cord-258129-c38q6xxs 35 9 in in IN cord-258129-c38q6xxs 35 10 the the DT cord-258129-c38q6xxs 35 11 pathogenesis pathogenesis NN cord-258129-c38q6xxs 35 12 of of IN cord-258129-c38q6xxs 35 13 a a DT cord-258129-c38q6xxs 35 14 number number NN cord-258129-c38q6xxs 35 15 of of IN cord-258129-c38q6xxs 35 16 infectious infectious JJ cord-258129-c38q6xxs 35 17 diseases disease NNS cord-258129-c38q6xxs 35 18 and and CC cord-258129-c38q6xxs 35 19 their -PRON- PRP$ cord-258129-c38q6xxs 35 20 complications complication NNS cord-258129-c38q6xxs 35 21 , , , cord-258129-c38q6xxs 35 22 including include VBG cord-258129-c38q6xxs 35 23 sepsis sepsis NN cord-258129-c38q6xxs 35 24 syndrome syndrome NN cord-258129-c38q6xxs 35 25 and and CC cord-258129-c38q6xxs 35 26 acute acute JJ cord-258129-c38q6xxs 35 27 respiratory respiratory JJ cord-258129-c38q6xxs 35 28 distress distress NN cord-258129-c38q6xxs 35 29 syndrome syndrome NN cord-258129-c38q6xxs 35 30 , , , cord-258129-c38q6xxs 35 31 we -PRON- PRP cord-258129-c38q6xxs 35 32 conducted conduct VBD cord-258129-c38q6xxs 35 33 a a DT cord-258129-c38q6xxs 35 34 review review NN cord-258129-c38q6xxs 35 35 of of IN cord-258129-c38q6xxs 35 36 the the DT cord-258129-c38q6xxs 35 37 literature literature NN cord-258129-c38q6xxs 35 38 to to TO cord-258129-c38q6xxs 35 39 determine determine VB cord-258129-c38q6xxs 35 40 what what WP cord-258129-c38q6xxs 35 41 is be VBZ cord-258129-c38q6xxs 35 42 currently currently RB cord-258129-c38q6xxs 35 43 known know VBN cord-258129-c38q6xxs 35 44 about about IN cord-258129-c38q6xxs 35 45 the the DT cord-258129-c38q6xxs 35 46 role role NN cord-258129-c38q6xxs 35 47 of of IN cord-258129-c38q6xxs 35 48 the the DT cord-258129-c38q6xxs 35 49 pro pro JJ cord-258129-c38q6xxs 35 50 - - JJ cord-258129-c38q6xxs 35 51 resolution resolution JJ cord-258129-c38q6xxs 35 52 lipid lipid NN cord-258129-c38q6xxs 35 53 mediators mediator NNS cord-258129-c38q6xxs 35 54 lipoxin lipoxin NNP cord-258129-c38q6xxs 35 55 , , , cord-258129-c38q6xxs 35 56 resolvin resolvin NNP cord-258129-c38q6xxs 35 57 and and CC cord-258129-c38q6xxs 35 58 protectin protectin NNP cord-258129-c38q6xxs 35 59 in in IN cord-258129-c38q6xxs 35 60 infectious infectious JJ cord-258129-c38q6xxs 35 61 disease disease NN cord-258129-c38q6xxs 35 62 . . . cord-258129-c38q6xxs 36 1 13 13 CD cord-258129-c38q6xxs 37 1 In in IN cord-258129-c38q6xxs 37 2 mice mouse NNS cord-258129-c38q6xxs 37 3 , , , cord-258129-c38q6xxs 37 4 H5N1 H5N1 NNP cord-258129-c38q6xxs 37 5 was be VBD cord-258129-c38q6xxs 37 6 more more RBR cord-258129-c38q6xxs 37 7 virulent virulent JJ cord-258129-c38q6xxs 37 8 ( ( -LRB- cord-258129-c38q6xxs 37 9 infection infection NN cord-258129-c38q6xxs 37 10 resulted result VBD cord-258129-c38q6xxs 37 11 in in IN cord-258129-c38q6xxs 37 12 shorter short JJR cord-258129-c38q6xxs 37 13 survival survival NN cord-258129-c38q6xxs 37 14 time time NN cord-258129-c38q6xxs 37 15 ) ) -RRB- cord-258129-c38q6xxs 37 16 than than IN cord-258129-c38q6xxs 37 17 the the DT cord-258129-c38q6xxs 37 18 H1N1 H1N1 NNP cord-258129-c38q6xxs 37 19 strain strain NN cord-258129-c38q6xxs 37 20 and and CC cord-258129-c38q6xxs 37 21 disseminated disseminate VBN cord-258129-c38q6xxs 37 22 to to IN cord-258129-c38q6xxs 37 23 extra extra JJ cord-258129-c38q6xxs 37 24 - - JJ cord-258129-c38q6xxs 37 25 pulmonary pulmonary JJ cord-258129-c38q6xxs 37 26 sites site NNS cord-258129-c38q6xxs 37 27 ( ( -LRB- cord-258129-c38q6xxs 37 28 brain brain NN cord-258129-c38q6xxs 37 29 and and CC cord-258129-c38q6xxs 37 30 spleen spleen NN cord-258129-c38q6xxs 37 31 ) ) -RRB- cord-258129-c38q6xxs 37 32 following follow VBG cord-258129-c38q6xxs 37 33 intra intra JJ cord-258129-c38q6xxs 37 34 - - JJ cord-258129-c38q6xxs 37 35 nasal nasal JJ cord-258129-c38q6xxs 37 36 inoculation inoculation NN cord-258129-c38q6xxs 37 37 . . . cord-258129-c38q6xxs 38 1 Global global JJ cord-258129-c38q6xxs 38 2 transcriptional transcriptional JJ cord-258129-c38q6xxs 38 3 responses response NNS cord-258129-c38q6xxs 38 4 to to IN cord-258129-c38q6xxs 38 5 infection infection NN cord-258129-c38q6xxs 38 6 were be VBD cord-258129-c38q6xxs 38 7 analysed analyse VBN cord-258129-c38q6xxs 38 8 and and CC cord-258129-c38q6xxs 38 9 showed show VBD cord-258129-c38q6xxs 38 10 that that IN cord-258129-c38q6xxs 38 11 the the DT cord-258129-c38q6xxs 38 12 different different JJ cord-258129-c38q6xxs 38 13 strains strain NNS cord-258129-c38q6xxs 38 14 of of IN cord-258129-c38q6xxs 38 15 influenza influenza NN cord-258129-c38q6xxs 38 16 A a DT cord-258129-c38q6xxs 38 17 virus virus NN cord-258129-c38q6xxs 38 18 caused cause VBD cord-258129-c38q6xxs 38 19 different different JJ cord-258129-c38q6xxs 38 20 early early JJ cord-258129-c38q6xxs 38 21 responses response NNS cord-258129-c38q6xxs 38 22 in in IN cord-258129-c38q6xxs 38 23 gene gene NN cord-258129-c38q6xxs 38 24 expression expression NN cord-258129-c38q6xxs 38 25 , , , cord-258129-c38q6xxs 38 26 and and CC cord-258129-c38q6xxs 38 27 that that IN cord-258129-c38q6xxs 38 28 many many JJ cord-258129-c38q6xxs 38 29 of of IN cord-258129-c38q6xxs 38 30 the the DT cord-258129-c38q6xxs 38 31 differentially differentially RB cord-258129-c38q6xxs 38 32 regulated regulate VBN cord-258129-c38q6xxs 38 33 genes gene NNS cord-258129-c38q6xxs 38 34 were be VBD cord-258129-c38q6xxs 38 35 components component NNS cord-258129-c38q6xxs 38 36 of of IN cord-258129-c38q6xxs 38 37 the the DT cord-258129-c38q6xxs 38 38 inflammatory inflammatory JJ cord-258129-c38q6xxs 38 39 response response NN cord-258129-c38q6xxs 38 40 . . . cord-258129-c38q6xxs 39 1 H5N1 H5N1 NNP cord-258129-c38q6xxs 39 2 infection infection NN cord-258129-c38q6xxs 39 3 was be VBD cord-258129-c38q6xxs 39 4 associated associate VBN cord-258129-c38q6xxs 39 5 with with IN cord-258129-c38q6xxs 39 6 up up IN cord-258129-c38q6xxs 39 7 - - HYPH cord-258129-c38q6xxs 39 8 regulation regulation NN cord-258129-c38q6xxs 39 9 of of IN cord-258129-c38q6xxs 39 10 inflammasome inflammasome NN cord-258129-c38q6xxs 39 11 genes gene NNS cord-258129-c38q6xxs 39 12 [ [ -LRB- cord-258129-c38q6xxs 39 13 including include VBG cord-258129-c38q6xxs 39 14 caspase caspase NN cord-258129-c38q6xxs 39 15 1 1 CD cord-258129-c38q6xxs 39 16 and and CC cord-258129-c38q6xxs 39 17 interleukin-1 interleukin-1 NN cord-258129-c38q6xxs 39 18 ( ( -LRB- cord-258129-c38q6xxs 39 19 IL-1 IL-1 NNP cord-258129-c38q6xxs 39 20 ) ) -RRB- cord-258129-c38q6xxs 39 21 ] ] -RRB- cord-258129-c38q6xxs 39 22 , , , cord-258129-c38q6xxs 39 23 tumour tumour NN cord-258129-c38q6xxs 39 24 necrosis necrosis NN cord-258129-c38q6xxs 39 25 factor factor NN cord-258129-c38q6xxs 39 26 - - : cord-258129-c38q6xxs 39 27 a a DT cord-258129-c38q6xxs 39 28 ( ( -LRB- cord-258129-c38q6xxs 39 29 TNF TNF NNP cord-258129-c38q6xxs 39 30 - - HYPH cord-258129-c38q6xxs 39 31 a a NNP cord-258129-c38q6xxs 39 32 ) ) -RRB- cord-258129-c38q6xxs 39 33 , , , cord-258129-c38q6xxs 39 34 interferon interferon NN cord-258129-c38q6xxs 39 35 - - HYPH cord-258129-c38q6xxs 39 36 c c NN cord-258129-c38q6xxs 39 37 ( ( -LRB- cord-258129-c38q6xxs 39 38 IFN IFN NNP cord-258129-c38q6xxs 39 39 - - HYPH cord-258129-c38q6xxs 39 40 c c NNP cord-258129-c38q6xxs 39 41 ) ) -RRB- cord-258129-c38q6xxs 39 42 and and CC cord-258129-c38q6xxs 39 43 protein protein NN cord-258129-c38q6xxs 39 44 kinase kinase NN cord-258129-c38q6xxs 39 45 R r NN cord-258129-c38q6xxs 39 46 , , , cord-258129-c38q6xxs 39 47 as as RB cord-258129-c38q6xxs 39 48 well well RB cord-258129-c38q6xxs 39 49 as as IN cord-258129-c38q6xxs 39 50 other other JJ cord-258129-c38q6xxs 39 51 inflammation inflammation NN cord-258129-c38q6xxs 39 52 - - HYPH cord-258129-c38q6xxs 39 53 related relate VBN cord-258129-c38q6xxs 39 54 genes gene NNS cord-258129-c38q6xxs 39 55 . . . cord-258129-c38q6xxs 40 1 Using use VBG cord-258129-c38q6xxs 40 2 a a DT cord-258129-c38q6xxs 40 3 bioinformatics bioinformatics NN cord-258129-c38q6xxs 40 4 approach approach NN cord-258129-c38q6xxs 40 5 to to TO cord-258129-c38q6xxs 40 6 analyse analyse VB cord-258129-c38q6xxs 40 7 gene gene NN cord-258129-c38q6xxs 40 8 expression expression NN cord-258129-c38q6xxs 40 9 , , , cord-258129-c38q6xxs 40 10 the the DT cord-258129-c38q6xxs 40 11 authors author NNS cord-258129-c38q6xxs 40 12 found find VBD cord-258129-c38q6xxs 40 13 that that IN cord-258129-c38q6xxs 40 14 extra extra JJ cord-258129-c38q6xxs 40 15 - - JJ cord-258129-c38q6xxs 40 16 pulmonary pulmonary JJ cord-258129-c38q6xxs 40 17 dissemination dissemination NN cord-258129-c38q6xxs 40 18 was be VBD cord-258129-c38q6xxs 40 19 associated associate VBN cord-258129-c38q6xxs 40 20 with with IN cord-258129-c38q6xxs 40 21 down down JJ cord-258129-c38q6xxs 40 22 - - HYPH cord-258129-c38q6xxs 40 23 regulation regulation NN cord-258129-c38q6xxs 40 24 of of IN cord-258129-c38q6xxs 40 25 genes gene NNS cord-258129-c38q6xxs 40 26 involved involve VBN cord-258129-c38q6xxs 40 27 in in IN cord-258129-c38q6xxs 40 28 mediating mediate VBG cord-258129-c38q6xxs 40 29 the the DT cord-258129-c38q6xxs 40 30 pro pro JJ cord-258129-c38q6xxs 40 31 - - JJ cord-258129-c38q6xxs 40 32 resolution resolution JJ cord-258129-c38q6xxs 40 33 effects effect NNS cord-258129-c38q6xxs 40 34 of of IN cord-258129-c38q6xxs 40 35 lipoxin lipoxin NNP cord-258129-c38q6xxs 40 36 on on IN cord-258129-c38q6xxs 40 37 leucocyte leucocyte NNP cord-258129-c38q6xxs 40 38 recruitment recruitment NNP cord-258129-c38q6xxs 40 39 and and CC cord-258129-c38q6xxs 40 40 counter counter JJ cord-258129-c38q6xxs 40 41 - - NN cord-258129-c38q6xxs 40 42 regulation regulation NN cord-258129-c38q6xxs 40 43 of of IN cord-258129-c38q6xxs 40 44 pro pro JJ cord-258129-c38q6xxs 40 45 - - JJ cord-258129-c38q6xxs 40 46 inflammatory inflammatory JJ cord-258129-c38q6xxs 40 47 cytokine cytokine NN cord-258129-c38q6xxs 40 48 induction induction NN cord-258129-c38q6xxs 40 49 . . . cord-258129-c38q6xxs 41 1 These these DT cord-258129-c38q6xxs 41 2 included include VBD cord-258129-c38q6xxs 41 3 the the DT cord-258129-c38q6xxs 41 4 suppressor suppressor NN cord-258129-c38q6xxs 41 5 of of IN cord-258129-c38q6xxs 41 6 cytokine cytokine NN cord-258129-c38q6xxs 41 7 signalling signalling NN cord-258129-c38q6xxs 41 8 ( ( -LRB- cord-258129-c38q6xxs 41 9 SOCS SOCS NNP cord-258129-c38q6xxs 41 10 ) ) -RRB- cord-258129-c38q6xxs 41 11 2 2 CD cord-258129-c38q6xxs 41 12 gene gene NN cord-258129-c38q6xxs 41 13 , , , cord-258129-c38q6xxs 41 14 the the DT cord-258129-c38q6xxs 41 15 product product NN cord-258129-c38q6xxs 41 16 of of IN cord-258129-c38q6xxs 41 17 which which WDT cord-258129-c38q6xxs 41 18 is be VBZ cord-258129-c38q6xxs 41 19 activated activate VBN cord-258129-c38q6xxs 41 20 by by IN cord-258129-c38q6xxs 41 21 lipoxins lipoxin NNS cord-258129-c38q6xxs 41 22 and and CC cord-258129-c38q6xxs 41 23 is be VBZ cord-258129-c38q6xxs 41 24 an an DT cord-258129-c38q6xxs 41 25 essential essential JJ cord-258129-c38q6xxs 41 26 intracellular intracellular JJ cord-258129-c38q6xxs 41 27 mediator mediator NN cord-258129-c38q6xxs 41 28 of of IN cord-258129-c38q6xxs 41 29 lipoxin lipoxin NNP cord-258129-c38q6xxs 41 30 's 's POS cord-258129-c38q6xxs 41 31 effects effect NNS cord-258129-c38q6xxs 41 32 on on IN cord-258129-c38q6xxs 41 33 inflammatory inflammatory JJ cord-258129-c38q6xxs 41 34 cell cell NN cord-258129-c38q6xxs 41 35 trafficking trafficking NN cord-258129-c38q6xxs 41 36 and and CC cord-258129-c38q6xxs 41 37 cytokine cytokine NN cord-258129-c38q6xxs 41 38 induction induction NN cord-258129-c38q6xxs 41 39 . . . cord-258129-c38q6xxs 42 1 14 14 CD cord-258129-c38q6xxs 43 1 Therefore therefore RB cord-258129-c38q6xxs 43 2 , , , cord-258129-c38q6xxs 43 3 loss loss NN cord-258129-c38q6xxs 43 4 of of IN cord-258129-c38q6xxs 43 5 lipoxin lipoxin NNP cord-258129-c38q6xxs 43 6 's 's POS cord-258129-c38q6xxs 43 7 pro pro JJ cord-258129-c38q6xxs 43 8 - - JJ cord-258129-c38q6xxs 43 9 resolution resolution JJ cord-258129-c38q6xxs 43 10 effects effect NNS cord-258129-c38q6xxs 43 11 may may MD cord-258129-c38q6xxs 43 12 be be VB cord-258129-c38q6xxs 43 13 associated associate VBN cord-258129-c38q6xxs 43 14 with with IN cord-258129-c38q6xxs 43 15 greater great JJR cord-258129-c38q6xxs 43 16 influenza influenza NN cord-258129-c38q6xxs 43 17 A a DT cord-258129-c38q6xxs 43 18 virus virus NN cord-258129-c38q6xxs 43 19 virulence virulence NN cord-258129-c38q6xxs 43 20 , , , cord-258129-c38q6xxs 43 21 suggesting suggest VBG cord-258129-c38q6xxs 43 22 a a DT cord-258129-c38q6xxs 43 23 protective protective JJ cord-258129-c38q6xxs 43 24 role role NN cord-258129-c38q6xxs 43 25 for for IN cord-258129-c38q6xxs 43 26 lipoxin lipoxin NNP cord-258129-c38q6xxs 43 27 in in IN cord-258129-c38q6xxs 43 28 this this DT cord-258129-c38q6xxs 43 29 infection infection NN cord-258129-c38q6xxs 43 30 , , , cord-258129-c38q6xxs 43 31 possibly possibly RB cord-258129-c38q6xxs 43 32 related related JJ cord-258129-c38q6xxs 43 33 to to IN cord-258129-c38q6xxs 43 34 the the DT cord-258129-c38q6xxs 43 35 suppression suppression NN cord-258129-c38q6xxs 43 36 of of IN cord-258129-c38q6xxs 43 37 pro pro JJ cord-258129-c38q6xxs 43 38 - - JJ cord-258129-c38q6xxs 43 39 inflammatory inflammatory JJ cord-258129-c38q6xxs 43 40 cytokines cytokine NNS cord-258129-c38q6xxs 43 41 that that WDT cord-258129-c38q6xxs 43 42 are be VBP cord-258129-c38q6xxs 43 43 up up RB cord-258129-c38q6xxs 43 44 - - HYPH cord-258129-c38q6xxs 43 45 regulated regulate VBN cord-258129-c38q6xxs 43 46 in in IN cord-258129-c38q6xxs 43 47 this this DT cord-258129-c38q6xxs 43 48 model model NN cord-258129-c38q6xxs 43 49 . . . cord-258129-c38q6xxs 44 1 The the DT cord-258129-c38q6xxs 44 2 highly highly RB cord-258129-c38q6xxs 44 3 pathogenic pathogenic JJ cord-258129-c38q6xxs 44 4 avian avian JJ cord-258129-c38q6xxs 44 5 H5N1 H5N1 NNP cord-258129-c38q6xxs 44 6 virus virus NN cord-258129-c38q6xxs 44 7 used use VBN cord-258129-c38q6xxs 44 8 in in IN cord-258129-c38q6xxs 44 9 this this DT cord-258129-c38q6xxs 44 10 study study NN cord-258129-c38q6xxs 44 11 was be VBD cord-258129-c38q6xxs 44 12 less less RBR cord-258129-c38q6xxs 44 13 successful successful JJ cord-258129-c38q6xxs 44 14 at at IN cord-258129-c38q6xxs 44 15 spreading spread VBG cord-258129-c38q6xxs 44 16 between between IN cord-258129-c38q6xxs 44 17 human human JJ cord-258129-c38q6xxs 44 18 hosts host NNS cord-258129-c38q6xxs 44 19 compared compare VBN cord-258129-c38q6xxs 44 20 with with IN cord-258129-c38q6xxs 44 21 other other JJ cord-258129-c38q6xxs 44 22 influenza influenza NN cord-258129-c38q6xxs 44 23 A a DT cord-258129-c38q6xxs 44 24 virus virus NN cord-258129-c38q6xxs 44 25 strains strain NNS cord-258129-c38q6xxs 44 26 , , , cord-258129-c38q6xxs 44 27 for for IN cord-258129-c38q6xxs 44 28 example example NN cord-258129-c38q6xxs 44 29 the the DT cord-258129-c38q6xxs 44 30 2009 2009 CD cord-258129-c38q6xxs 44 31 H1N1 H1N1 NNP cord-258129-c38q6xxs 44 32 pandemic pandemic NN cord-258129-c38q6xxs 44 33 strain strain NN cord-258129-c38q6xxs 44 34 . . . cord-258129-c38q6xxs 45 1 A a DT cord-258129-c38q6xxs 45 2 successful successful JJ cord-258129-c38q6xxs 45 3 pathogen pathogen NN cord-258129-c38q6xxs 45 4 minimizes minimize VBZ cord-258129-c38q6xxs 45 5 damage damage NN cord-258129-c38q6xxs 45 6 to to IN cord-258129-c38q6xxs 45 7 its -PRON- PRP$ cord-258129-c38q6xxs 45 8 host host NN cord-258129-c38q6xxs 45 9 to to TO cord-258129-c38q6xxs 45 10 prolong prolong VB cord-258129-c38q6xxs 45 11 the the DT cord-258129-c38q6xxs 45 12 availability availability NN cord-258129-c38q6xxs 45 13 of of IN cord-258129-c38q6xxs 45 14 its -PRON- PRP$ cord-258129-c38q6xxs 45 15 replicative replicative JJ cord-258129-c38q6xxs 45 16 niche niche NN cord-258129-c38q6xxs 45 17 and and CC cord-258129-c38q6xxs 45 18 the the DT cord-258129-c38q6xxs 45 19 high high JJ cord-258129-c38q6xxs 45 20 case case NN cord-258129-c38q6xxs 45 21 - - HYPH cord-258129-c38q6xxs 45 22 mortality mortality NN cord-258129-c38q6xxs 45 23 seen see VBN cord-258129-c38q6xxs 45 24 with with IN cord-258129-c38q6xxs 45 25 infection infection NN cord-258129-c38q6xxs 45 26 by by IN cord-258129-c38q6xxs 45 27 this this DT cord-258129-c38q6xxs 45 28 H5N1 H5N1 NNP cord-258129-c38q6xxs 45 29 strain strain NN cord-258129-c38q6xxs 45 30 indicates indicate VBZ cord-258129-c38q6xxs 45 31 that that IN cord-258129-c38q6xxs 45 32 it -PRON- PRP cord-258129-c38q6xxs 45 33 is be VBZ cord-258129-c38q6xxs 45 34 not not RB cord-258129-c38q6xxs 45 35 well well RB cord-258129-c38q6xxs 45 36 adapted adapt VBN cord-258129-c38q6xxs 45 37 to to IN cord-258129-c38q6xxs 45 38 humans human NNS cord-258129-c38q6xxs 45 39 . . . cord-258129-c38q6xxs 46 1 Reduction reduction NN cord-258129-c38q6xxs 46 2 of of IN cord-258129-c38q6xxs 46 3 lipoxin lipoxin NN cord-258129-c38q6xxs 46 4 - - HYPH cord-258129-c38q6xxs 46 5 mediated mediate VBN cord-258129-c38q6xxs 46 6 pro pro JJ cord-258129-c38q6xxs 46 7 - - JJ cord-258129-c38q6xxs 46 8 resolution resolution JJ cord-258129-c38q6xxs 46 9 effects effect NNS cord-258129-c38q6xxs 46 10 may may MD cord-258129-c38q6xxs 46 11 contribute contribute VB cord-258129-c38q6xxs 46 12 to to IN cord-258129-c38q6xxs 46 13 the the DT cord-258129-c38q6xxs 46 14 virus virus NN cord-258129-c38q6xxs 46 15 's 's POS cord-258129-c38q6xxs 46 16 poor poor JJ cord-258129-c38q6xxs 46 17 adaptation adaptation NN cord-258129-c38q6xxs 46 18 to to IN cord-258129-c38q6xxs 46 19 humans human NNS cord-258129-c38q6xxs 46 20 . . . cord-258129-c38q6xxs 47 1 In in IN cord-258129-c38q6xxs 47 2 a a DT cord-258129-c38q6xxs 47 3 recent recent JJ cord-258129-c38q6xxs 47 4 study study NN cord-258129-c38q6xxs 47 5 , , , cord-258129-c38q6xxs 47 6 respiratory respiratory JJ cord-258129-c38q6xxs 47 7 syncytial syncytial JJ cord-258129-c38q6xxs 47 8 virus virus NN cord-258129-c38q6xxs 47 9 ( ( -LRB- cord-258129-c38q6xxs 47 10 RSV RSV NNP cord-258129-c38q6xxs 47 11 ) ) -RRB- cord-258129-c38q6xxs 47 12 infection infection NN cord-258129-c38q6xxs 47 13 of of IN cord-258129-c38q6xxs 47 14 mice mouse NNS cord-258129-c38q6xxs 47 15 deficient deficient JJ cord-258129-c38q6xxs 47 16 in in IN cord-258129-c38q6xxs 47 17 5-lipoxygenase 5-lipoxygenase CD cord-258129-c38q6xxs 47 18 , , , cord-258129-c38q6xxs 47 19 an an DT cord-258129-c38q6xxs 47 20 enzyme enzyme NN cord-258129-c38q6xxs 47 21 required require VBN cord-258129-c38q6xxs 47 22 for for IN cord-258129-c38q6xxs 47 23 lipoxin lipoxin NNP cord-258129-c38q6xxs 47 24 production production NN cord-258129-c38q6xxs 47 25 , , , cord-258129-c38q6xxs 47 26 failed fail VBD cord-258129-c38q6xxs 47 27 to to TO cord-258129-c38q6xxs 47 28 elicit elicit VB cord-258129-c38q6xxs 47 29 alternative alternative JJ cord-258129-c38q6xxs 47 30 macrophage macrophage NN cord-258129-c38q6xxs 47 31 differentiation differentiation NN cord-258129-c38q6xxs 47 32 , , , cord-258129-c38q6xxs 47 33 which which WDT cord-258129-c38q6xxs 47 34 is be VBZ cord-258129-c38q6xxs 47 35 known know VBN cord-258129-c38q6xxs 47 36 to to TO cord-258129-c38q6xxs 47 37 be be VB cord-258129-c38q6xxs 47 38 required require VBN cord-258129-c38q6xxs 47 39 for for IN cord-258129-c38q6xxs 47 40 the the DT cord-258129-c38q6xxs 47 41 resolution resolution NN cord-258129-c38q6xxs 47 42 of of IN cord-258129-c38q6xxs 47 43 RSV RSV NNP cord-258129-c38q6xxs 47 44 - - HYPH cord-258129-c38q6xxs 47 45 induced induce VBN cord-258129-c38q6xxs 47 46 lung lung NN cord-258129-c38q6xxs 47 47 injury injury NN cord-258129-c38q6xxs 47 48 . . . cord-258129-c38q6xxs 48 1 15 15 CD cord-258129-c38q6xxs 48 2 , , , cord-258129-c38q6xxs 48 3 16 16 CD cord-258129-c38q6xxs 48 4 Alternatively alternatively RB cord-258129-c38q6xxs 48 5 activated activate VBN cord-258129-c38q6xxs 48 6 macrophages macrophage NNS cord-258129-c38q6xxs 48 7 are be VBP cord-258129-c38q6xxs 48 8 thought think VBN cord-258129-c38q6xxs 48 9 to to TO cord-258129-c38q6xxs 48 10 induce induce VB cord-258129-c38q6xxs 48 11 anti anti JJ cord-258129-c38q6xxs 48 12 - - JJ cord-258129-c38q6xxs 48 13 inflammatory inflammatory JJ cord-258129-c38q6xxs 48 14 cytokine cytokine NN cord-258129-c38q6xxs 48 15 expression expression NN cord-258129-c38q6xxs 48 16 and and CC cord-258129-c38q6xxs 48 17 drive drive NN cord-258129-c38q6xxs 48 18 lung lung NN cord-258129-c38q6xxs 48 19 tissue tissue NN cord-258129-c38q6xxs 48 20 repair repair NN cord-258129-c38q6xxs 48 21 . . . cord-258129-c38q6xxs 49 1 16 16 CD cord-258129-c38q6xxs 50 1 Significantly significantly RB cord-258129-c38q6xxs 50 2 , , , cord-258129-c38q6xxs 50 3 RSV RSV NNP cord-258129-c38q6xxs 50 4 infection infection NN cord-258129-c38q6xxs 50 5 of of IN cord-258129-c38q6xxs 50 6 these these DT cord-258129-c38q6xxs 50 7 5-lipoxygenase 5-lipoxygenase CD cord-258129-c38q6xxs 50 8 - - HYPH cord-258129-c38q6xxs 50 9 deficient deficient JJ cord-258129-c38q6xxs 50 10 mice mouse NNS cord-258129-c38q6xxs 50 11 resulted result VBD cord-258129-c38q6xxs 50 12 in in IN cord-258129-c38q6xxs 50 13 greater great JJR cord-258129-c38q6xxs 50 14 lung lung NN cord-258129-c38q6xxs 50 15 pathology pathology NN cord-258129-c38q6xxs 50 16 on on IN cord-258129-c38q6xxs 50 17 histological histological JJ cord-258129-c38q6xxs 50 18 analysis analysis NN cord-258129-c38q6xxs 50 19 ( ( -LRB- cord-258129-c38q6xxs 50 20 increased increase VBN cord-258129-c38q6xxs 50 21 peribronchiolitis peribronchiolitis NN cord-258129-c38q6xxs 50 22 , , , cord-258129-c38q6xxs 50 23 perivasculitis perivasculitis NNP cord-258129-c38q6xxs 50 24 , , , cord-258129-c38q6xxs 50 25 interstitial interstitial JJ cord-258129-c38q6xxs 50 26 pneumonitis pneumonitis NN cord-258129-c38q6xxs 50 27 and and CC cord-258129-c38q6xxs 50 28 alveolitis alveolitis NNP cord-258129-c38q6xxs 50 29 ) ) -RRB- cord-258129-c38q6xxs 50 30 in in IN cord-258129-c38q6xxs 50 31 comparison comparison NN cord-258129-c38q6xxs 50 32 to to IN cord-258129-c38q6xxs 50 33 infected infect VBN cord-258129-c38q6xxs 50 34 wild wild JJ cord-258129-c38q6xxs 50 35 - - HYPH cord-258129-c38q6xxs 50 36 type type NN cord-258129-c38q6xxs 50 37 mice mouse NNS cord-258129-c38q6xxs 50 38 . . . cord-258129-c38q6xxs 51 1 15 15 CD cord-258129-c38q6xxs 51 2 Treatment Treatment NNP cord-258129-c38q6xxs 51 3 with with IN cord-258129-c38q6xxs 51 4 lipoxin lipoxin NNP cord-258129-c38q6xxs 51 5 A4 A4 NNP cord-258129-c38q6xxs 51 6 and and CC cord-258129-c38q6xxs 51 7 resolvin resolvin NNP cord-258129-c38q6xxs 51 8 E1 E1 NNP cord-258129-c38q6xxs 51 9 partially partially RB cord-258129-c38q6xxs 51 10 restored restore VBD cord-258129-c38q6xxs 51 11 the the DT cord-258129-c38q6xxs 51 12 alternatively alternatively RB cord-258129-c38q6xxs 51 13 activated activate VBN cord-258129-c38q6xxs 51 14 macrophage macrophage NN cord-258129-c38q6xxs 51 15 phenotype phenotype NN cord-258129-c38q6xxs 51 16 in in IN cord-258129-c38q6xxs 51 17 the the DT cord-258129-c38q6xxs 51 18 5-lipoxygenase 5-lipoxygenase CD cord-258129-c38q6xxs 51 19 - - HYPH cord-258129-c38q6xxs 51 20 deficient deficient JJ cord-258129-c38q6xxs 51 21 mice mouse NNS cord-258129-c38q6xxs 51 22 . . . cord-258129-c38q6xxs 52 1 These these DT cord-258129-c38q6xxs 52 2 observations observation NNS cord-258129-c38q6xxs 52 3 support support VBP cord-258129-c38q6xxs 52 4 a a DT cord-258129-c38q6xxs 52 5 pro pro JJ cord-258129-c38q6xxs 52 6 - - JJ cord-258129-c38q6xxs 52 7 resolution resolution JJ cord-258129-c38q6xxs 52 8 role role NN cord-258129-c38q6xxs 52 9 for for IN cord-258129-c38q6xxs 52 10 lipoxins lipoxin NNS cord-258129-c38q6xxs 52 11 in in IN cord-258129-c38q6xxs 52 12 viral viral JJ cord-258129-c38q6xxs 52 13 respiratory respiratory JJ cord-258129-c38q6xxs 52 14 tract tract NN cord-258129-c38q6xxs 52 15 infection infection NN cord-258129-c38q6xxs 52 16 . . . cord-258129-c38q6xxs 53 1 Alveolar alveolar JJ cord-258129-c38q6xxs 53 2 macrophages macrophage NNS cord-258129-c38q6xxs 53 3 are be VBP cord-258129-c38q6xxs 53 4 the the DT cord-258129-c38q6xxs 53 5 major major JJ cord-258129-c38q6xxs 53 6 resident resident JJ cord-258129-c38q6xxs 53 7 inflammatory inflammatory JJ cord-258129-c38q6xxs 53 8 cell cell NN cord-258129-c38q6xxs 53 9 of of IN cord-258129-c38q6xxs 53 10 the the DT cord-258129-c38q6xxs 53 11 respiratory respiratory JJ cord-258129-c38q6xxs 53 12 tract tract NN cord-258129-c38q6xxs 53 13 and and CC cord-258129-c38q6xxs 53 14 are be VBP cord-258129-c38q6xxs 53 15 able able JJ cord-258129-c38q6xxs 53 16 to to TO cord-258129-c38q6xxs 53 17 produce produce VB cord-258129-c38q6xxs 53 18 lipoxins lipoxin NNS cord-258129-c38q6xxs 53 19 . . . cord-258129-c38q6xxs 54 1 Alveolar alveolar NN cord-258129-c38q6xxs 54 2 macrophages macrophage NNS cord-258129-c38q6xxs 54 3 isolated isolate VBN cord-258129-c38q6xxs 54 4 from from IN cord-258129-c38q6xxs 54 5 rats rat NNS cord-258129-c38q6xxs 54 6 that that WDT cord-258129-c38q6xxs 54 7 had have VBD cord-258129-c38q6xxs 54 8 previously previously RB cord-258129-c38q6xxs 54 9 been be VBN cord-258129-c38q6xxs 54 10 infected infect VBN cord-258129-c38q6xxs 54 11 with with IN cord-258129-c38q6xxs 54 12 a a DT cord-258129-c38q6xxs 54 13 range range NN cord-258129-c38q6xxs 54 14 of of IN cord-258129-c38q6xxs 54 15 respiratory respiratory JJ cord-258129-c38q6xxs 54 16 viruses virus NNS cord-258129-c38q6xxs 54 17 ( ( -LRB- cord-258129-c38q6xxs 54 18 murine murine JJ cord-258129-c38q6xxs 54 19 parainfluenza parainfluenza NNP cord-258129-c38q6xxs 54 20 virus virus NNP cord-258129-c38q6xxs 54 21 type type NNP cord-258129-c38q6xxs 54 22 1 1 CD cord-258129-c38q6xxs 54 23 , , , cord-258129-c38q6xxs 54 24 rat rat NN cord-258129-c38q6xxs 54 25 coronavirus coronavirus NN cord-258129-c38q6xxs 54 26 , , , cord-258129-c38q6xxs 54 27 pneumonia pneumonia NN cord-258129-c38q6xxs 54 28 virus virus NN cord-258129-c38q6xxs 54 29 of of IN cord-258129-c38q6xxs 54 30 mice mouse NNS cord-258129-c38q6xxs 54 31 and and CC cord-258129-c38q6xxs 54 32 mouse mouse NN cord-258129-c38q6xxs 54 33 adenovirus adenovirus NN cord-258129-c38q6xxs 54 34 ) ) -RRB- cord-258129-c38q6xxs 54 35 produced produce VBD cord-258129-c38q6xxs 54 36 higher high JJR cord-258129-c38q6xxs 54 37 levels level NNS cord-258129-c38q6xxs 54 38 of of IN cord-258129-c38q6xxs 54 39 lipoxin lipoxin NN cord-258129-c38q6xxs 54 40 than than IN cord-258129-c38q6xxs 54 41 macrophages macrophage NNS cord-258129-c38q6xxs 54 42 from from IN cord-258129-c38q6xxs 54 43 rats rat NNS cord-258129-c38q6xxs 54 44 that that WDT cord-258129-c38q6xxs 54 45 had have VBD cord-258129-c38q6xxs 54 46 been be VBN cord-258129-c38q6xxs 54 47 kept keep VBN cord-258129-c38q6xxs 54 48 in in IN cord-258129-c38q6xxs 54 49 sterile sterile JJ cord-258129-c38q6xxs 54 50 conditions condition NNS cord-258129-c38q6xxs 54 51 since since IN cord-258129-c38q6xxs 54 52 birth birth NN cord-258129-c38q6xxs 54 53 . . . cord-258129-c38q6xxs 55 1 17 17 CD cord-258129-c38q6xxs 56 1 These these DT cord-258129-c38q6xxs 56 2 findings finding NNS cord-258129-c38q6xxs 56 3 suggest suggest VBP cord-258129-c38q6xxs 56 4 that that IN cord-258129-c38q6xxs 56 5 virus virus NN cord-258129-c38q6xxs 56 6 - - HYPH cord-258129-c38q6xxs 56 7 induced induce VBN cord-258129-c38q6xxs 56 8 pulmonary pulmonary JJ cord-258129-c38q6xxs 56 9 inflammation inflammation NN cord-258129-c38q6xxs 56 10 is be VBZ cord-258129-c38q6xxs 56 11 a a DT cord-258129-c38q6xxs 56 12 stimulus stimulus NN cord-258129-c38q6xxs 56 13 for for IN cord-258129-c38q6xxs 56 14 the the DT cord-258129-c38q6xxs 56 15 production production NN cord-258129-c38q6xxs 56 16 of of IN cord-258129-c38q6xxs 56 17 lipoxins lipoxin NNS cord-258129-c38q6xxs 56 18 . . . cord-258129-c38q6xxs 57 1 In in IN cord-258129-c38q6xxs 57 2 a a DT cord-258129-c38q6xxs 57 3 cell cell NN cord-258129-c38q6xxs 57 4 culture culture NN cord-258129-c38q6xxs 57 5 model model NN cord-258129-c38q6xxs 57 6 of of IN cord-258129-c38q6xxs 57 7 HIV HIV NNP cord-258129-c38q6xxs 57 8 central central JJ cord-258129-c38q6xxs 57 9 nervous nervous JJ cord-258129-c38q6xxs 57 10 system system NN cord-258129-c38q6xxs 57 11 infection infection NN cord-258129-c38q6xxs 57 12 , , , cord-258129-c38q6xxs 57 13 following follow VBG cord-258129-c38q6xxs 57 14 co co NN cord-258129-c38q6xxs 57 15 - - NN cord-258129-c38q6xxs 57 16 culture culture NN cord-258129-c38q6xxs 57 17 of of IN cord-258129-c38q6xxs 57 18 HIV HIV NNP cord-258129-c38q6xxs 57 19 - - HYPH cord-258129-c38q6xxs 57 20 infected infect VBN cord-258129-c38q6xxs 57 21 monocytes monocyte NNS cord-258129-c38q6xxs 57 22 with with IN cord-258129-c38q6xxs 57 23 astroglia astroglia NNP cord-258129-c38q6xxs 57 24 , , , cord-258129-c38q6xxs 57 25 TNF TNF NNP cord-258129-c38q6xxs 57 26 - - : cord-258129-c38q6xxs 57 27 a a NNP cord-258129-c38q6xxs 57 28 and and CC cord-258129-c38q6xxs 57 29 IL-1b IL-1b NNS cord-258129-c38q6xxs 57 30 were be VBD cord-258129-c38q6xxs 57 31 produced produce VBN cord-258129-c38q6xxs 57 32 and and CC cord-258129-c38q6xxs 57 33 this this DT cord-258129-c38q6xxs 57 34 production production NN cord-258129-c38q6xxs 57 35 correlated correlate VBN cord-258129-c38q6xxs 57 36 with with IN cord-258129-c38q6xxs 57 37 synthesis synthesis NN cord-258129-c38q6xxs 57 38 of of IN cord-258129-c38q6xxs 57 39 large large JJ cord-258129-c38q6xxs 57 40 amounts amount NNS cord-258129-c38q6xxs 57 41 of of IN cord-258129-c38q6xxs 57 42 leukotriene leukotriene NN cord-258129-c38q6xxs 57 43 B4 B4 NNP cord-258129-c38q6xxs 57 44 , , , cord-258129-c38q6xxs 57 45 leukotriene leukotriene NN cord-258129-c38q6xxs 57 46 D4 d4 NN cord-258129-c38q6xxs 57 47 and and CC cord-258129-c38q6xxs 57 48 lipoxin lipoxin NNP cord-258129-c38q6xxs 57 49 A4 A4 NNP cord-258129-c38q6xxs 57 50 . . . cord-258129-c38q6xxs 58 1 18 18 CD cord-258129-c38q6xxs 59 1 This this DT cord-258129-c38q6xxs 59 2 is be VBZ cord-258129-c38q6xxs 59 3 the the DT cord-258129-c38q6xxs 59 4 only only JJ cord-258129-c38q6xxs 59 5 study study NN cord-258129-c38q6xxs 59 6 to to TO cord-258129-c38q6xxs 59 7 demonstrate demonstrate VB cord-258129-c38q6xxs 59 8 , , , cord-258129-c38q6xxs 59 9 albeit albeit IN cord-258129-c38q6xxs 59 10 in in IN cord-258129-c38q6xxs 59 11 vitro vitro FW cord-258129-c38q6xxs 59 12 , , , cord-258129-c38q6xxs 59 13 that that IN cord-258129-c38q6xxs 59 14 lipoxins lipoxin NNS cord-258129-c38q6xxs 59 15 are be VBP cord-258129-c38q6xxs 59 16 produced produce VBN cord-258129-c38q6xxs 59 17 in in IN cord-258129-c38q6xxs 59 18 direct direct JJ cord-258129-c38q6xxs 59 19 response response NN cord-258129-c38q6xxs 59 20 to to IN cord-258129-c38q6xxs 59 21 viral viral JJ cord-258129-c38q6xxs 59 22 infection infection NN cord-258129-c38q6xxs 59 23 . . . cord-258129-c38q6xxs 60 1 However however RB cord-258129-c38q6xxs 60 2 , , , cord-258129-c38q6xxs 60 3 the the DT cord-258129-c38q6xxs 60 4 role role NN cord-258129-c38q6xxs 60 5 of of IN cord-258129-c38q6xxs 60 6 lipoxin lipoxin NNP cord-258129-c38q6xxs 60 7 in in IN cord-258129-c38q6xxs 60 8 this this DT cord-258129-c38q6xxs 60 9 model model NN cord-258129-c38q6xxs 60 10 of of IN cord-258129-c38q6xxs 60 11 infection infection NN cord-258129-c38q6xxs 60 12 has have VBZ cord-258129-c38q6xxs 60 13 not not RB cord-258129-c38q6xxs 60 14 been be VBN cord-258129-c38q6xxs 60 15 investigated investigate VBN cord-258129-c38q6xxs 60 16 . . . cord-258129-c38q6xxs 61 1 Following follow VBG cord-258129-c38q6xxs 61 2 aerosol aerosol NN cord-258129-c38q6xxs 61 3 infection infection NN cord-258129-c38q6xxs 61 4 with with IN cord-258129-c38q6xxs 61 5 Mycobacterium Mycobacterium NNP cord-258129-c38q6xxs 61 6 tuberculosis tuberculosis NN cord-258129-c38q6xxs 61 7 , , , cord-258129-c38q6xxs 61 8 mice mouse NNS cord-258129-c38q6xxs 61 9 have have VBP cord-258129-c38q6xxs 61 10 been be VBN cord-258129-c38q6xxs 61 11 shown show VBN cord-258129-c38q6xxs 61 12 to to TO cord-258129-c38q6xxs 61 13 produce produce VB cord-258129-c38q6xxs 61 14 high high JJ cord-258129-c38q6xxs 61 15 levels level NNS cord-258129-c38q6xxs 61 16 of of IN cord-258129-c38q6xxs 61 17 lipoxin lipoxin NNP cord-258129-c38q6xxs 61 18 A4 A4 NNP cord-258129-c38q6xxs 61 19 during during IN cord-258129-c38q6xxs 61 20 chronic chronic JJ cord-258129-c38q6xxs 61 21 infection infection NN cord-258129-c38q6xxs 61 22 . . . cord-258129-c38q6xxs 62 1 19 19 CD cord-258129-c38q6xxs 62 2 Pulmonary pulmonary JJ cord-258129-c38q6xxs 62 3 endothelial endothelial JJ cord-258129-c38q6xxs 62 4 cells cell NNS cord-258129-c38q6xxs 62 5 and and CC cord-258129-c38q6xxs 62 6 macrophages macrophage NNS cord-258129-c38q6xxs 62 7 were be VBD cord-258129-c38q6xxs 62 8 responsible responsible JJ cord-258129-c38q6xxs 62 9 for for IN cord-258129-c38q6xxs 62 10 this this DT cord-258129-c38q6xxs 62 11 . . . cord-258129-c38q6xxs 63 1 Transgenic transgenic JJ cord-258129-c38q6xxs 63 2 mice mouse NNS cord-258129-c38q6xxs 63 3 deficient deficient JJ cord-258129-c38q6xxs 63 4 in in IN cord-258129-c38q6xxs 63 5 5-lipoxygenase 5-lipoxygenase CD cord-258129-c38q6xxs 63 6 , , , cord-258129-c38q6xxs 63 7 an an DT cord-258129-c38q6xxs 63 8 enzyme enzyme NN cord-258129-c38q6xxs 63 9 required require VBN cord-258129-c38q6xxs 63 10 for for IN cord-258129-c38q6xxs 63 11 lipoxin lipoxin NNP cord-258129-c38q6xxs 63 12 production production NN cord-258129-c38q6xxs 63 13 , , , cord-258129-c38q6xxs 63 14 were be VBD cord-258129-c38q6xxs 63 15 able able JJ cord-258129-c38q6xxs 63 16 to to TO cord-258129-c38q6xxs 63 17 control control VB cord-258129-c38q6xxs 63 18 M. M. NNP cord-258129-c38q6xxs 63 19 tuberculosis tuberculosis NN cord-258129-c38q6xxs 63 20 infection infection NN cord-258129-c38q6xxs 63 21 better well RBR cord-258129-c38q6xxs 63 22 than than IN cord-258129-c38q6xxs 63 23 wild wild JJ cord-258129-c38q6xxs 63 24 - - HYPH cord-258129-c38q6xxs 63 25 type type NN cord-258129-c38q6xxs 63 26 mice mouse NNS cord-258129-c38q6xxs 63 27 , , , cord-258129-c38q6xxs 63 28 as as IN cord-258129-c38q6xxs 63 29 demonstrated demonstrate VBN cord-258129-c38q6xxs 63 30 by by IN cord-258129-c38q6xxs 63 31 lower low JJR cord-258129-c38q6xxs 63 32 pulmonary pulmonary JJ cord-258129-c38q6xxs 63 33 and and CC cord-258129-c38q6xxs 63 34 splenic splenic JJ cord-258129-c38q6xxs 63 35 titres titre NNS cord-258129-c38q6xxs 63 36 of of IN cord-258129-c38q6xxs 63 37 viable viable JJ cord-258129-c38q6xxs 63 38 M. M. NNP cord-258129-c38q6xxs 63 39 tuberculosis tuberculosis NN cord-258129-c38q6xxs 63 40 ( ( -LRB- cord-258129-c38q6xxs 63 41 at at IN cord-258129-c38q6xxs 63 42 21 21 CD cord-258129-c38q6xxs 63 43 and and CC cord-258129-c38q6xxs 63 44 42 42 CD cord-258129-c38q6xxs 63 45 days day NNS cord-258129-c38q6xxs 63 46 ) ) -RRB- cord-258129-c38q6xxs 63 47 . . . cord-258129-c38q6xxs 64 1 On on IN cord-258129-c38q6xxs 64 2 histological histological JJ cord-258129-c38q6xxs 64 3 examination examination NN cord-258129-c38q6xxs 64 4 of of IN cord-258129-c38q6xxs 64 5 lung lung NN cord-258129-c38q6xxs 64 6 tissue tissue NN cord-258129-c38q6xxs 64 7 , , , cord-258129-c38q6xxs 64 8 extensive extensive JJ cord-258129-c38q6xxs 64 9 inflammation inflammation NN cord-258129-c38q6xxs 64 10 and and CC cord-258129-c38q6xxs 64 11 areas area NNS cord-258129-c38q6xxs 64 12 of of IN cord-258129-c38q6xxs 64 13 necrosis necrosis NN cord-258129-c38q6xxs 64 14 were be VBD cord-258129-c38q6xxs 64 15 seen see VBN cord-258129-c38q6xxs 64 16 in in IN cord-258129-c38q6xxs 64 17 wild wild JJ cord-258129-c38q6xxs 64 18 - - HYPH cord-258129-c38q6xxs 64 19 type type NN cord-258129-c38q6xxs 64 20 mice mouse NNS cord-258129-c38q6xxs 64 21 whereas whereas IN cord-258129-c38q6xxs 64 22 the the DT cord-258129-c38q6xxs 64 23 transgenic transgenic JJ cord-258129-c38q6xxs 64 24 mice mouse NNS cord-258129-c38q6xxs 64 25 had have VBD cord-258129-c38q6xxs 64 26 a a DT cord-258129-c38q6xxs 64 27 lesser less JJR cord-258129-c38q6xxs 64 28 degree degree NN cord-258129-c38q6xxs 64 29 of of IN cord-258129-c38q6xxs 64 30 inflammation inflammation NN cord-258129-c38q6xxs 64 31 and and CC cord-258129-c38q6xxs 64 32 little little JJ cord-258129-c38q6xxs 64 33 evidence evidence NN cord-258129-c38q6xxs 64 34 of of IN cord-258129-c38q6xxs 64 35 necrosis necrosis NN cord-258129-c38q6xxs 64 36 . . . cord-258129-c38q6xxs 65 1 Importantly importantly RB cord-258129-c38q6xxs 65 2 , , , cord-258129-c38q6xxs 65 3 the the DT cord-258129-c38q6xxs 65 4 transgenic transgenic JJ cord-258129-c38q6xxs 65 5 mice mouse NNS cord-258129-c38q6xxs 65 6 unable unable JJ cord-258129-c38q6xxs 65 7 to to TO cord-258129-c38q6xxs 65 8 produce produce VB cord-258129-c38q6xxs 65 9 lipoxin lipoxin NNP cord-258129-c38q6xxs 65 10 enjoyed enjoy VBN cord-258129-c38q6xxs 65 11 enhanced enhanced JJ cord-258129-c38q6xxs 65 12 survival survival NN cord-258129-c38q6xxs 65 13 in in IN cord-258129-c38q6xxs 65 14 this this DT cord-258129-c38q6xxs 65 15 model model NN cord-258129-c38q6xxs 65 16 of of IN cord-258129-c38q6xxs 65 17 M. M. NNP cord-258129-c38q6xxs 65 18 tuberculosis tuberculosis NN cord-258129-c38q6xxs 65 19 infection infection NN cord-258129-c38q6xxs 65 20 and and CC cord-258129-c38q6xxs 65 21 had have VBD cord-258129-c38q6xxs 65 22 increased increase VBN cord-258129-c38q6xxs 65 23 pulmonary pulmonary JJ cord-258129-c38q6xxs 65 24 levels level NNS cord-258129-c38q6xxs 65 25 of of IN cord-258129-c38q6xxs 65 26 IL-12 IL-12 NNP cord-258129-c38q6xxs 65 27 , , , cord-258129-c38q6xxs 65 28 IFN IFN NNP cord-258129-c38q6xxs 65 29 - - HYPH cord-258129-c38q6xxs 65 30 c c NNP cord-258129-c38q6xxs 65 31 and and CC cord-258129-c38q6xxs 65 32 inducible inducible JJ cord-258129-c38q6xxs 65 33 nitric nitric NN cord-258129-c38q6xxs 65 34 oxide oxide NN cord-258129-c38q6xxs 65 35 synthase synthase NN cord-258129-c38q6xxs 65 36 , , , cord-258129-c38q6xxs 65 37 which which WDT cord-258129-c38q6xxs 65 38 is be VBZ cord-258129-c38q6xxs 65 39 known know VBN cord-258129-c38q6xxs 65 40 to to TO cord-258129-c38q6xxs 65 41 have have VB cord-258129-c38q6xxs 65 42 a a DT cord-258129-c38q6xxs 65 43 protective protective JJ cord-258129-c38q6xxs 65 44 role role NN cord-258129-c38q6xxs 65 45 in in IN cord-258129-c38q6xxs 65 46 host host NN cord-258129-c38q6xxs 65 47 control control NN cord-258129-c38q6xxs 65 48 of of IN cord-258129-c38q6xxs 65 49 M. M. NNP cord-258129-c38q6xxs 65 50 tuberculosis tuberculosis NN cord-258129-c38q6xxs 65 51 infection infection NN cord-258129-c38q6xxs 65 52 in in IN cord-258129-c38q6xxs 65 53 mice mouse NNS cord-258129-c38q6xxs 65 54 . . . cord-258129-c38q6xxs 66 1 20 20 CD cord-258129-c38q6xxs 66 2 Oral oral JJ cord-258129-c38q6xxs 66 3 administration administration NN cord-258129-c38q6xxs 66 4 of of IN cord-258129-c38q6xxs 66 5 a a DT cord-258129-c38q6xxs 66 6 lipoxin lipoxin NNP cord-258129-c38q6xxs 66 7 A4 A4 NNP cord-258129-c38q6xxs 66 8 analogue analogue NN cord-258129-c38q6xxs 66 9 reversed reverse VBD cord-258129-c38q6xxs 66 10 the the DT cord-258129-c38q6xxs 66 11 enhanced enhanced JJ cord-258129-c38q6xxs 66 12 control control NN cord-258129-c38q6xxs 66 13 of of IN cord-258129-c38q6xxs 66 14 infection infection NN cord-258129-c38q6xxs 66 15 in in IN cord-258129-c38q6xxs 66 16 the the DT cord-258129-c38q6xxs 66 17 transgenic transgenic JJ cord-258129-c38q6xxs 66 18 mice mouse NNS cord-258129-c38q6xxs 66 19 , , , cord-258129-c38q6xxs 66 20 and and CC cord-258129-c38q6xxs 66 21 splenocytes splenocyte NNS cord-258129-c38q6xxs 66 22 from from IN cord-258129-c38q6xxs 66 23 these these DT cord-258129-c38q6xxs 66 24 mice mouse NNS cord-258129-c38q6xxs 66 25 showed show VBD cord-258129-c38q6xxs 66 26 reduced reduce VBN cord-258129-c38q6xxs 66 27 IFN IFN NNP cord-258129-c38q6xxs 66 28 - - HYPH cord-258129-c38q6xxs 66 29 c c NNP cord-258129-c38q6xxs 66 30 production production NN cord-258129-c38q6xxs 66 31 . . . cord-258129-c38q6xxs 67 1 In in IN cord-258129-c38q6xxs 67 2 a a DT cord-258129-c38q6xxs 67 3 mouse mouse NN cord-258129-c38q6xxs 67 4 model model NN cord-258129-c38q6xxs 67 5 of of IN cord-258129-c38q6xxs 67 6 Toxoplasma toxoplasma JJ cord-258129-c38q6xxs 67 7 gondii gondii NNP cord-258129-c38q6xxs 67 8 infection infection NN cord-258129-c38q6xxs 67 9 ( ( -LRB- cord-258129-c38q6xxs 67 10 established establish VBN cord-258129-c38q6xxs 67 11 through through IN cord-258129-c38q6xxs 67 12 intraperitoneal intraperitoneal JJ cord-258129-c38q6xxs 67 13 inoculation inoculation NN cord-258129-c38q6xxs 67 14 of of IN cord-258129-c38q6xxs 67 15 T. t. NN cord-258129-c38q6xxs 67 16 gondii gondii NNP cord-258129-c38q6xxs 67 17 cysts cyst NNS cord-258129-c38q6xxs 67 18 ) ) -RRB- cord-258129-c38q6xxs 67 19 , , , cord-258129-c38q6xxs 67 20 serum serum NN cord-258129-c38q6xxs 67 21 levels level NNS cord-258129-c38q6xxs 67 22 of of IN cord-258129-c38q6xxs 67 23 lipoxin lipoxin NNP cord-258129-c38q6xxs 67 24 A4 A4 NNP cord-258129-c38q6xxs 67 25 rise rise NN cord-258129-c38q6xxs 67 26 during during IN cord-258129-c38q6xxs 67 27 infection infection NN cord-258129-c38q6xxs 67 28 and and CC cord-258129-c38q6xxs 67 29 remain remain VBP cord-258129-c38q6xxs 67 30 high high JJ cord-258129-c38q6xxs 67 31 once once RB cord-258129-c38q6xxs 67 32 chronic chronic JJ cord-258129-c38q6xxs 67 33 infection infection NN cord-258129-c38q6xxs 67 34 has have VBZ cord-258129-c38q6xxs 67 35 been be VBN cord-258129-c38q6xxs 67 36 established establish VBN cord-258129-c38q6xxs 67 37 . . . cord-258129-c38q6xxs 68 1 21 21 CD cord-258129-c38q6xxs 68 2 Transgenic transgenic JJ cord-258129-c38q6xxs 68 3 mice mouse NNS cord-258129-c38q6xxs 68 4 unable unable JJ cord-258129-c38q6xxs 68 5 to to TO cord-258129-c38q6xxs 68 6 produce produce VB cord-258129-c38q6xxs 68 7 lipoxin lipoxin NNP cord-258129-c38q6xxs 68 8 A4 A4 NNP cord-258129-c38q6xxs 68 9 suffered suffer VBD cord-258129-c38q6xxs 68 10 increased increased JJ cord-258129-c38q6xxs 68 11 mortality mortality NN cord-258129-c38q6xxs 68 12 following follow VBG cord-258129-c38q6xxs 68 13 infection infection NN cord-258129-c38q6xxs 68 14 , , , cord-258129-c38q6xxs 68 15 compared compare VBN cord-258129-c38q6xxs 68 16 with with IN cord-258129-c38q6xxs 68 17 wild wild JJ cord-258129-c38q6xxs 68 18 - - HYPH cord-258129-c38q6xxs 68 19 type type NN cord-258129-c38q6xxs 68 20 control control NN cord-258129-c38q6xxs 68 21 animals animal NNS cord-258129-c38q6xxs 68 22 . . . cord-258129-c38q6xxs 69 1 14,21 14,21 CD cord-258129-c38q6xxs 70 1 Interestingly interestingly RB cord-258129-c38q6xxs 70 2 , , , cord-258129-c38q6xxs 70 3 fewer few JJR cord-258129-c38q6xxs 70 4 T. t. NN cord-258129-c38q6xxs 70 5 gondii gondii NN cord-258129-c38q6xxs 70 6 brain brain NN cord-258129-c38q6xxs 70 7 cysts cyst NNS cord-258129-c38q6xxs 70 8 were be VBD cord-258129-c38q6xxs 70 9 seen see VBN cord-258129-c38q6xxs 70 10 in in IN cord-258129-c38q6xxs 70 11 the the DT cord-258129-c38q6xxs 70 12 lipoxin lipoxin NN cord-258129-c38q6xxs 70 13 - - HYPH cord-258129-c38q6xxs 70 14 deficient deficient JJ cord-258129-c38q6xxs 70 15 mice mouse NNS cord-258129-c38q6xxs 70 16 and and CC cord-258129-c38q6xxs 70 17 consistent consistent JJ cord-258129-c38q6xxs 70 18 with with IN cord-258129-c38q6xxs 70 19 this this DT cord-258129-c38q6xxs 70 20 , , , cord-258129-c38q6xxs 70 21 lower low JJR cord-258129-c38q6xxs 70 22 parasitic parasitic JJ cord-258129-c38q6xxs 70 23 burden burden NN cord-258129-c38q6xxs 70 24 and and CC cord-258129-c38q6xxs 70 25 increased increase VBN cord-258129-c38q6xxs 70 26 serum serum NN cord-258129-c38q6xxs 70 27 levels level NNS cord-258129-c38q6xxs 70 28 of of IN cord-258129-c38q6xxs 71 1 IL-12 IL-12 NNP cord-258129-c38q6xxs 71 2 and and CC cord-258129-c38q6xxs 71 3 IFN IFN NNP cord-258129-c38q6xxs 71 4 - - HYPH cord-258129-c38q6xxs 71 5 c c NNP cord-258129-c38q6xxs 71 6 were be VBD cord-258129-c38q6xxs 71 7 seen see VBN cord-258129-c38q6xxs 71 8 when when WRB cord-258129-c38q6xxs 71 9 compared compare VBN cord-258129-c38q6xxs 71 10 with with IN cord-258129-c38q6xxs 71 11 wild wild JJ cord-258129-c38q6xxs 71 12 - - HYPH cord-258129-c38q6xxs 71 13 type type NN cord-258129-c38q6xxs 71 14 mice mouse NNS cord-258129-c38q6xxs 71 15 . . . cord-258129-c38q6xxs 72 1 Therefore therefore RB cord-258129-c38q6xxs 72 2 , , , cord-258129-c38q6xxs 72 3 it -PRON- PRP cord-258129-c38q6xxs 72 4 seems seem VBZ cord-258129-c38q6xxs 72 5 likely likely JJ cord-258129-c38q6xxs 72 6 that that IN cord-258129-c38q6xxs 72 7 the the DT cord-258129-c38q6xxs 72 8 increased increase VBN cord-258129-c38q6xxs 72 9 mortality mortality NN cord-258129-c38q6xxs 72 10 of of IN cord-258129-c38q6xxs 72 11 the the DT cord-258129-c38q6xxs 72 12 lipoxin lipoxin NN cord-258129-c38q6xxs 72 13 - - HYPH cord-258129-c38q6xxs 72 14 deficient deficient JJ cord-258129-c38q6xxs 72 15 mice mice NN cord-258129-c38q6xxs 72 16 is be VBZ cord-258129-c38q6xxs 72 17 attributable attributable JJ cord-258129-c38q6xxs 72 18 to to IN cord-258129-c38q6xxs 72 19 cytokine cytokine NN cord-258129-c38q6xxs 72 20 - - HYPH cord-258129-c38q6xxs 72 21 mediated mediate VBN cord-258129-c38q6xxs 72 22 tissue tissue NN cord-258129-c38q6xxs 72 23 damage damage NN cord-258129-c38q6xxs 72 24 , , , cord-258129-c38q6xxs 72 25 despite despite IN cord-258129-c38q6xxs 72 26 better well JJR cord-258129-c38q6xxs 72 27 parasite parasite NN cord-258129-c38q6xxs 72 28 control control NN cord-258129-c38q6xxs 72 29 . . . cord-258129-c38q6xxs 73 1 Corroborating corroborate VBG cord-258129-c38q6xxs 73 2 this this DT cord-258129-c38q6xxs 73 3 , , , cord-258129-c38q6xxs 73 4 increased increase VBN cord-258129-c38q6xxs 73 5 histological histological JJ cord-258129-c38q6xxs 73 6 severity severity NN cord-258129-c38q6xxs 73 7 of of IN cord-258129-c38q6xxs 73 8 meningitis meningitis NN cord-258129-c38q6xxs 73 9 and and CC cord-258129-c38q6xxs 73 10 encephalitis encephalitis JJ cord-258129-c38q6xxs 73 11 was be VBD cord-258129-c38q6xxs 73 12 observed observe VBN cord-258129-c38q6xxs 73 13 in in IN cord-258129-c38q6xxs 73 14 the the DT cord-258129-c38q6xxs 73 15 transgenic transgenic JJ cord-258129-c38q6xxs 73 16 mice mouse NNS cord-258129-c38q6xxs 73 17 . . . cord-258129-c38q6xxs 74 1 Administration administration NN cord-258129-c38q6xxs 74 2 of of IN cord-258129-c38q6xxs 74 3 a a DT cord-258129-c38q6xxs 74 4 lipoxin lipoxin NNP cord-258129-c38q6xxs 74 5 analogue analogue NN cord-258129-c38q6xxs 74 6 rescued rescue VBD cord-258129-c38q6xxs 74 7 the the DT cord-258129-c38q6xxs 74 8 lipoxin lipoxin NN cord-258129-c38q6xxs 74 9 - - HYPH cord-258129-c38q6xxs 74 10 deficient deficient JJ cord-258129-c38q6xxs 74 11 mice mouse NNS cord-258129-c38q6xxs 74 12 from from IN cord-258129-c38q6xxs 74 13 this this DT cord-258129-c38q6xxs 74 14 fatal fatal JJ cord-258129-c38q6xxs 74 15 phenotype phenotype NN cord-258129-c38q6xxs 74 16 and and CC cord-258129-c38q6xxs 74 17 lowered lower VBD cord-258129-c38q6xxs 74 18 IL-12 IL-12 NNP cord-258129-c38q6xxs 74 19 and and CC cord-258129-c38q6xxs 74 20 IFN IFN NNP cord-258129-c38q6xxs 74 21 - - HYPH cord-258129-c38q6xxs 74 22 c c NNP cord-258129-c38q6xxs 74 23 levels level NNS cord-258129-c38q6xxs 74 24 ( ( -LRB- cord-258129-c38q6xxs 74 25 to to IN cord-258129-c38q6xxs 74 26 wild wild JJ cord-258129-c38q6xxs 74 27 - - HYPH cord-258129-c38q6xxs 74 28 type type NN cord-258129-c38q6xxs 74 29 levels level NNS cord-258129-c38q6xxs 74 30 in in IN cord-258129-c38q6xxs 74 31 the the DT cord-258129-c38q6xxs 74 32 case case NN cord-258129-c38q6xxs 74 33 of of IN cord-258129-c38q6xxs 74 34 IFN IFN NNP cord-258129-c38q6xxs 74 35 - - HYPH cord-258129-c38q6xxs 74 36 c c NNP cord-258129-c38q6xxs 74 37 ) ) -RRB- cord-258129-c38q6xxs 74 38 . . . cord-258129-c38q6xxs 75 1 Interleukin-12 Interleukin-12 NNP cord-258129-c38q6xxs 75 2 , , , cord-258129-c38q6xxs 75 3 produced produce VBN cord-258129-c38q6xxs 75 4 by by IN cord-258129-c38q6xxs 75 5 antigen antigen NN cord-258129-c38q6xxs 75 6 - - HYPH cord-258129-c38q6xxs 75 7 presenting present VBG cord-258129-c38q6xxs 75 8 cells cell NNS cord-258129-c38q6xxs 75 9 such such JJ cord-258129-c38q6xxs 75 10 as as IN cord-258129-c38q6xxs 75 11 dendritic dendritic JJ cord-258129-c38q6xxs 75 12 cells cell NNS cord-258129-c38q6xxs 75 13 , , , cord-258129-c38q6xxs 75 14 has have VBZ cord-258129-c38q6xxs 75 15 an an DT cord-258129-c38q6xxs 75 16 important important JJ cord-258129-c38q6xxs 75 17 role role NN cord-258129-c38q6xxs 75 18 in in IN cord-258129-c38q6xxs 75 19 host host NN cord-258129-c38q6xxs 75 20 control control NN cord-258129-c38q6xxs 75 21 of of IN cord-258129-c38q6xxs 75 22 intracellular intracellular JJ cord-258129-c38q6xxs 75 23 pathogens pathogen NNS cord-258129-c38q6xxs 75 24 such such JJ cord-258129-c38q6xxs 75 25 as as IN cord-258129-c38q6xxs 75 26 T. T. NNP cord-258129-c38q6xxs 75 27 gondii gondii NN cord-258129-c38q6xxs 75 28 and and CC cord-258129-c38q6xxs 75 29 viruses virus NNS cord-258129-c38q6xxs 75 30 , , , cord-258129-c38q6xxs 75 31 but but CC cord-258129-c38q6xxs 75 32 in in IN cord-258129-c38q6xxs 75 33 excess excess NN cord-258129-c38q6xxs 75 34 can can MD cord-258129-c38q6xxs 75 35 cause cause VB cord-258129-c38q6xxs 75 36 immunopathology immunopathology NN cord-258129-c38q6xxs 75 37 . . . cord-258129-c38q6xxs 76 1 In in IN cord-258129-c38q6xxs 76 2 mice mouse NNS cord-258129-c38q6xxs 76 3 , , , cord-258129-c38q6xxs 76 4 it -PRON- PRP cord-258129-c38q6xxs 76 5 has have VBZ cord-258129-c38q6xxs 76 6 been be VBN cord-258129-c38q6xxs 76 7 shown show VBN cord-258129-c38q6xxs 76 8 that that IN cord-258129-c38q6xxs 76 9 lipoxin lipoxin NNP cord-258129-c38q6xxs 76 10 A4 A4 NNP cord-258129-c38q6xxs 76 11 analogues analogue NNS cord-258129-c38q6xxs 76 12 suppress suppress VBP cord-258129-c38q6xxs 76 13 IL-12 IL-12 NNP cord-258129-c38q6xxs 76 14 production production NN cord-258129-c38q6xxs 76 15 by by IN cord-258129-c38q6xxs 76 16 dendritic dendritic JJ cord-258129-c38q6xxs 76 17 cells cell NNS cord-258129-c38q6xxs 76 18 stimulated stimulate VBN cord-258129-c38q6xxs 76 19 with with IN cord-258129-c38q6xxs 76 20 T. T. NNP cord-258129-c38q6xxs 76 21 gondii gondii NN cord-258129-c38q6xxs 76 22 extract extract NN cord-258129-c38q6xxs 76 23 . . . cord-258129-c38q6xxs 77 1 22 22 CD cord-258129-c38q6xxs 78 1 Although although IN cord-258129-c38q6xxs 78 2 this this DT cord-258129-c38q6xxs 78 3 may may MD cord-258129-c38q6xxs 78 4 be be VB cord-258129-c38q6xxs 78 5 a a DT cord-258129-c38q6xxs 78 6 host host NN cord-258129-c38q6xxs 78 7 - - HYPH cord-258129-c38q6xxs 78 8 driven drive VBN cord-258129-c38q6xxs 78 9 response response NN cord-258129-c38q6xxs 78 10 to to TO cord-258129-c38q6xxs 78 11 curb curb VB cord-258129-c38q6xxs 78 12 excessive excessive JJ cord-258129-c38q6xxs 78 13 inflammation inflammation NN cord-258129-c38q6xxs 78 14 , , , cord-258129-c38q6xxs 78 15 induction induction NN cord-258129-c38q6xxs 78 16 of of IN cord-258129-c38q6xxs 78 17 lipoxin lipoxin NNP cord-258129-c38q6xxs 78 18 production production NN cord-258129-c38q6xxs 78 19 could could MD cord-258129-c38q6xxs 78 20 be be VB cord-258129-c38q6xxs 78 21 a a DT cord-258129-c38q6xxs 78 22 strategy strategy NN cord-258129-c38q6xxs 78 23 adopted adopt VBN cord-258129-c38q6xxs 78 24 by by IN cord-258129-c38q6xxs 78 25 pathogens pathogen NNS cord-258129-c38q6xxs 78 26 to to TO cord-258129-c38q6xxs 78 27 modulate modulate VB cord-258129-c38q6xxs 78 28 host host NN cord-258129-c38q6xxs 78 29 immunity immunity NN cord-258129-c38q6xxs 78 30 and and CC cord-258129-c38q6xxs 78 31 perhaps perhaps RB cord-258129-c38q6xxs 78 32 facilitate facilitate VB cord-258129-c38q6xxs 78 33 chronic chronic JJ cord-258129-c38q6xxs 78 34 infection infection NN cord-258129-c38q6xxs 78 35 by by IN cord-258129-c38q6xxs 78 36 reducing reduce VBG cord-258129-c38q6xxs 78 37 tissue tissue NN cord-258129-c38q6xxs 78 38 damage damage NN cord-258129-c38q6xxs 78 39 . . . cord-258129-c38q6xxs 79 1 The the DT cord-258129-c38q6xxs 79 2 contrasting contrast VBG cord-258129-c38q6xxs 79 3 roles role NNS cord-258129-c38q6xxs 79 4 of of IN cord-258129-c38q6xxs 79 5 lipoxins lipoxin NNS cord-258129-c38q6xxs 79 6 in in IN cord-258129-c38q6xxs 79 7 these these DT cord-258129-c38q6xxs 79 8 two two CD cord-258129-c38q6xxs 79 9 models model NNS cord-258129-c38q6xxs 79 10 of of IN cord-258129-c38q6xxs 79 11 infection infection NN cord-258129-c38q6xxs 79 12 may may MD cord-258129-c38q6xxs 79 13 relate relate VB cord-258129-c38q6xxs 79 14 to to IN cord-258129-c38q6xxs 79 15 the the DT cord-258129-c38q6xxs 79 16 dynamics dynamic NNS cord-258129-c38q6xxs 79 17 of of IN cord-258129-c38q6xxs 79 18 the the DT cord-258129-c38q6xxs 79 19 specific specific JJ cord-258129-c38q6xxs 79 20 pathogen pathogen NN cord-258129-c38q6xxs 79 21 - - HYPH cord-258129-c38q6xxs 79 22 host host NN cord-258129-c38q6xxs 79 23 interactions interaction NNS cord-258129-c38q6xxs 79 24 . . . cord-258129-c38q6xxs 80 1 Toxoplasma toxoplasma NN cord-258129-c38q6xxs 80 2 gondii gondii NN cord-258129-c38q6xxs 80 3 replicates replicate VBZ cord-258129-c38q6xxs 80 4 more more RBR cord-258129-c38q6xxs 80 5 quickly quickly RB cord-258129-c38q6xxs 80 6 than than IN cord-258129-c38q6xxs 80 7 M. M. NNP cord-258129-c38q6xxs 80 8 tuberculosis tuberculosis NN cord-258129-c38q6xxs 80 9 and and CC cord-258129-c38q6xxs 80 10 the the DT cord-258129-c38q6xxs 80 11 risk risk NN cord-258129-c38q6xxs 80 12 of of IN cord-258129-c38q6xxs 80 13 excessive excessive JJ cord-258129-c38q6xxs 80 14 inflammation inflammation NN cord-258129-c38q6xxs 80 15 and and CC cord-258129-c38q6xxs 80 16 ensuing ensue VBG cord-258129-c38q6xxs 80 17 immunopathology immunopathology NN cord-258129-c38q6xxs 80 18 may may MD cord-258129-c38q6xxs 80 19 therefore therefore RB cord-258129-c38q6xxs 80 20 be be VB cord-258129-c38q6xxs 80 21 greater great JJR cord-258129-c38q6xxs 80 22 . . . cord-258129-c38q6xxs 81 1 19 19 CD cord-258129-c38q6xxs 82 1 By by IN cord-258129-c38q6xxs 82 2 preventing prevent VBG cord-258129-c38q6xxs 82 3 this this DT cord-258129-c38q6xxs 82 4 , , , cord-258129-c38q6xxs 82 5 lipoxins lipoxin NNS cord-258129-c38q6xxs 82 6 are be VBP cord-258129-c38q6xxs 82 7 beneficial beneficial JJ cord-258129-c38q6xxs 82 8 to to IN cord-258129-c38q6xxs 82 9 the the DT cord-258129-c38q6xxs 82 10 host host NN cord-258129-c38q6xxs 82 11 , , , cord-258129-c38q6xxs 82 12 and and CC cord-258129-c38q6xxs 82 13 so so RB cord-258129-c38q6xxs 82 14 enhance enhance VB cord-258129-c38q6xxs 82 15 survival survival NN cord-258129-c38q6xxs 82 16 . . . cord-258129-c38q6xxs 83 1 Mycobacterium Mycobacterium NNP cord-258129-c38q6xxs 83 2 tuberculosis tuberculosis NN cord-258129-c38q6xxs 83 3 induces induce VBZ cord-258129-c38q6xxs 83 4 a a DT cord-258129-c38q6xxs 83 5 weaker weak JJR cord-258129-c38q6xxs 83 6 T T NNP cord-258129-c38q6xxs 83 7 helper helper NN cord-258129-c38q6xxs 83 8 1 1 CD cord-258129-c38q6xxs 83 9 cell cell NN cord-258129-c38q6xxs 83 10 response response NN cord-258129-c38q6xxs 83 11 in in IN cord-258129-c38q6xxs 83 12 mice mouse NNS cord-258129-c38q6xxs 83 13 than than IN cord-258129-c38q6xxs 83 14 T. t. NN cord-258129-c38q6xxs 83 15 gondii gondii NN cord-258129-c38q6xxs 83 16 and and CC cord-258129-c38q6xxs 83 17 replicates replicate VBZ cord-258129-c38q6xxs 83 18 more more RBR cord-258129-c38q6xxs 83 19 slowly slowly RB cord-258129-c38q6xxs 83 20 , , , cord-258129-c38q6xxs 83 21 therefore therefore RB cord-258129-c38q6xxs 83 22 the the DT cord-258129-c38q6xxs 83 23 enhanced enhanced JJ cord-258129-c38q6xxs 83 24 inflammatory inflammatory JJ cord-258129-c38q6xxs 83 25 response response NN cord-258129-c38q6xxs 83 26 seen see VBN cord-258129-c38q6xxs 83 27 in in IN cord-258129-c38q6xxs 83 28 the the DT cord-258129-c38q6xxs 83 29 lipoxin lipoxin NN cord-258129-c38q6xxs 83 30 - - HYPH cord-258129-c38q6xxs 83 31 deficient deficient JJ cord-258129-c38q6xxs 83 32 mice mouse NNS cord-258129-c38q6xxs 83 33 may may MD cord-258129-c38q6xxs 83 34 be be VB cord-258129-c38q6xxs 83 35 advantageous advantageous JJ cord-258129-c38q6xxs 83 36 , , , cord-258129-c38q6xxs 83 37 by by IN cord-258129-c38q6xxs 83 38 ' ' `` cord-258129-c38q6xxs 83 39 topping topping NN cord-258129-c38q6xxs 83 40 - - HYPH cord-258129-c38q6xxs 83 41 up up RP cord-258129-c38q6xxs 83 42 ' ' '' cord-258129-c38q6xxs 83 43 existing exist VBG cord-258129-c38q6xxs 83 44 host host NN cord-258129-c38q6xxs 83 45 control control NN cord-258129-c38q6xxs 83 46 . . . cord-258129-c38q6xxs 84 1 The the DT cord-258129-c38q6xxs 84 2 reduced reduce VBN cord-258129-c38q6xxs 84 3 tissue tissue NN cord-258129-c38q6xxs 84 4 damage damage NN cord-258129-c38q6xxs 84 5 seen see VBN cord-258129-c38q6xxs 84 6 in in IN cord-258129-c38q6xxs 84 7 lipoxin lipoxin NN cord-258129-c38q6xxs 84 8 - - HYPH cord-258129-c38q6xxs 84 9 deficient deficient JJ cord-258129-c38q6xxs 84 10 mice mouse NNS cord-258129-c38q6xxs 84 11 may may MD cord-258129-c38q6xxs 84 12 be be VB cord-258129-c38q6xxs 84 13 a a DT cord-258129-c38q6xxs 84 14 result result NN cord-258129-c38q6xxs 84 15 of of IN cord-258129-c38q6xxs 84 16 better well JJR cord-258129-c38q6xxs 84 17 control control NN cord-258129-c38q6xxs 84 18 of of IN cord-258129-c38q6xxs 84 19 M. M. NNP cord-258129-c38q6xxs 84 20 tuberculosis tuberculosis NN cord-258129-c38q6xxs 84 21 replication replication NN cord-258129-c38q6xxs 84 22 . . . cord-258129-c38q6xxs 85 1 It -PRON- PRP cord-258129-c38q6xxs 85 2 is be VBZ cord-258129-c38q6xxs 85 3 also also RB cord-258129-c38q6xxs 85 4 important important JJ cord-258129-c38q6xxs 85 5 to to TO cord-258129-c38q6xxs 85 6 note note VB cord-258129-c38q6xxs 85 7 that that IN cord-258129-c38q6xxs 85 8 the the DT cord-258129-c38q6xxs 85 9 local local JJ cord-258129-c38q6xxs 85 10 ( ( -LRB- cord-258129-c38q6xxs 85 11 lung lung NN cord-258129-c38q6xxs 85 12 versus versus IN cord-258129-c38q6xxs 85 13 peritoneum/ peritoneum/ NN cord-258129-c38q6xxs 85 14 brain brain NN cord-258129-c38q6xxs 85 15 ) ) -RRB- cord-258129-c38q6xxs 85 16 biosynthesis biosynthesis NN cord-258129-c38q6xxs 85 17 and and CC cord-258129-c38q6xxs 85 18 actions action NNS cord-258129-c38q6xxs 85 19 of of IN cord-258129-c38q6xxs 85 20 lipoxin lipoxin NNP cord-258129-c38q6xxs 85 21 may may MD cord-258129-c38q6xxs 85 22 differ differ VB cord-258129-c38q6xxs 85 23 between between IN cord-258129-c38q6xxs 85 24 these these DT cord-258129-c38q6xxs 85 25 two two CD cord-258129-c38q6xxs 85 26 infection infection NN cord-258129-c38q6xxs 85 27 models model NNS cord-258129-c38q6xxs 85 28 and and CC cord-258129-c38q6xxs 85 29 could could MD cord-258129-c38q6xxs 85 30 provide provide VB cord-258129-c38q6xxs 85 31 an an DT cord-258129-c38q6xxs 85 32 alternative alternative JJ cord-258129-c38q6xxs 85 33 explanation explanation NN cord-258129-c38q6xxs 85 34 for for IN cord-258129-c38q6xxs 85 35 the the DT cord-258129-c38q6xxs 85 36 different different JJ cord-258129-c38q6xxs 85 37 outcomes outcome NNS cord-258129-c38q6xxs 85 38 observed observe VBN cord-258129-c38q6xxs 85 39 . . . cord-258129-c38q6xxs 86 1 In in IN cord-258129-c38q6xxs 86 2 a a DT cord-258129-c38q6xxs 86 3 mouse mouse NN cord-258129-c38q6xxs 86 4 model model NN cord-258129-c38q6xxs 86 5 of of IN cord-258129-c38q6xxs 86 6 Trypanosoma Trypanosoma NNP cord-258129-c38q6xxs 86 7 cruzi cruzi NNP cord-258129-c38q6xxs 86 8 infection infection NN cord-258129-c38q6xxs 86 9 , , , cord-258129-c38q6xxs 86 10 it -PRON- PRP cord-258129-c38q6xxs 86 11 was be VBD cord-258129-c38q6xxs 86 12 found find VBN cord-258129-c38q6xxs 86 13 that that IN cord-258129-c38q6xxs 86 14 the the DT cord-258129-c38q6xxs 86 15 administration administration NN cord-258129-c38q6xxs 86 16 of of IN cord-258129-c38q6xxs 86 17 aspirin aspirin NNP cord-258129-c38q6xxs 86 18 ( ( -LRB- cord-258129-c38q6xxs 86 19 acetylsalicylic acetylsalicylic JJ cord-258129-c38q6xxs 86 20 acid acid NN cord-258129-c38q6xxs 86 21 ) ) -RRB- cord-258129-c38q6xxs 86 22 at at IN cord-258129-c38q6xxs 86 23 doses dose NNS cord-258129-c38q6xxs 86 24 of of IN cord-258129-c38q6xxs 86 25 25 25 CD cord-258129-c38q6xxs 86 26 or or CC cord-258129-c38q6xxs 86 27 50 50 CD cord-258129-c38q6xxs 86 28 mg mg NNP cord-258129-c38q6xxs 86 29 / / SYM cord-258129-c38q6xxs 86 30 kg kg NNP cord-258129-c38q6xxs 86 31 increased increase VBN cord-258129-c38q6xxs 86 32 survival survival NN cord-258129-c38q6xxs 86 33 and and CC cord-258129-c38q6xxs 86 34 decreased decrease VBD cord-258129-c38q6xxs 86 35 peak peak NN cord-258129-c38q6xxs 86 36 parasitaemia parasitaemia NN cord-258129-c38q6xxs 86 37 , , , cord-258129-c38q6xxs 86 38 whereas whereas IN cord-258129-c38q6xxs 86 39 higher high JJR cord-258129-c38q6xxs 86 40 or or CC cord-258129-c38q6xxs 86 41 lower low JJR cord-258129-c38q6xxs 86 42 doses dose NNS cord-258129-c38q6xxs 86 43 had have VBD cord-258129-c38q6xxs 86 44 no no DT cord-258129-c38q6xxs 86 45 effect effect NN cord-258129-c38q6xxs 86 46 . . . cord-258129-c38q6xxs 87 1 23 23 CD cord-258129-c38q6xxs 88 1 The the DT cord-258129-c38q6xxs 88 2 aspirin aspirin NN cord-258129-c38q6xxs 88 3 - - HYPH cord-258129-c38q6xxs 88 4 triggered trigger VBN cord-258129-c38q6xxs 88 5 lipoxin lipoxin NN cord-258129-c38q6xxs 88 6 , , , cord-258129-c38q6xxs 88 7 15epi 15epi CD cord-258129-c38q6xxs 88 8 - - HYPH cord-258129-c38q6xxs 88 9 lipoxin lipoxin NNP cord-258129-c38q6xxs 88 10 A4 A4 NNP cord-258129-c38q6xxs 88 11 , , , cord-258129-c38q6xxs 88 12 was be VBD cord-258129-c38q6xxs 88 13 found find VBN cord-258129-c38q6xxs 88 14 to to TO cord-258129-c38q6xxs 88 15 be be VB cord-258129-c38q6xxs 88 16 increased increase VBN cord-258129-c38q6xxs 88 17 by by IN cord-258129-c38q6xxs 88 18 administration administration NN cord-258129-c38q6xxs 88 19 of of IN cord-258129-c38q6xxs 88 20 aspirin aspirin NN cord-258129-c38q6xxs 88 21 in in IN cord-258129-c38q6xxs 88 22 both both DT cord-258129-c38q6xxs 88 23 in in IN cord-258129-c38q6xxs 88 24 vitro vitro FW cord-258129-c38q6xxs 88 25 and and CC cord-258129-c38q6xxs 88 26 in in IN cord-258129-c38q6xxs 88 27 vivo vivo NN cord-258129-c38q6xxs 88 28 models model NNS cord-258129-c38q6xxs 88 29 of of IN cord-258129-c38q6xxs 88 30 infection infection NN cord-258129-c38q6xxs 88 31 , , , cord-258129-c38q6xxs 88 32 with with IN cord-258129-c38q6xxs 88 33 infection infection NN cord-258129-c38q6xxs 88 34 alone alone RB cord-258129-c38q6xxs 88 35 also also RB cord-258129-c38q6xxs 88 36 increasing increase VBG cord-258129-c38q6xxs 88 37 15-epi 15-epi CD cord-258129-c38q6xxs 88 38 - - HYPH cord-258129-c38q6xxs 88 39 lipoxin lipoxin NNP cord-258129-c38q6xxs 88 40 A4 A4 NNP cord-258129-c38q6xxs 88 41 levels level NNS cord-258129-c38q6xxs 88 42 . . . cord-258129-c38q6xxs 89 1 Exogenous exogenous JJ cord-258129-c38q6xxs 89 2 administration administration NN cord-258129-c38q6xxs 89 3 of of IN cord-258129-c38q6xxs 89 4 15-epi 15-epi CD cord-258129-c38q6xxs 89 5 - - HYPH cord-258129-c38q6xxs 89 6 lipoxin lipoxin NNP cord-258129-c38q6xxs 89 7 A4 A4 NNP cord-258129-c38q6xxs 89 8 was be VBD cord-258129-c38q6xxs 89 9 found find VBN cord-258129-c38q6xxs 89 10 to to TO cord-258129-c38q6xxs 89 11 decrease decrease VB cord-258129-c38q6xxs 89 12 parasitaemia parasitaemia NN cord-258129-c38q6xxs 89 13 peaks peak NNS cord-258129-c38q6xxs 89 14 and and CC cord-258129-c38q6xxs 89 15 decrease decrease VB cord-258129-c38q6xxs 89 16 cardiac cardiac JJ cord-258129-c38q6xxs 89 17 inflammation inflammation NN cord-258129-c38q6xxs 89 18 and and CC cord-258129-c38q6xxs 89 19 increase increase VB cord-258129-c38q6xxs 89 20 survival survival NN cord-258129-c38q6xxs 89 21 . . . cord-258129-c38q6xxs 90 1 The the DT cord-258129-c38q6xxs 90 2 authors author NNS cord-258129-c38q6xxs 90 3 therefore therefore RB cord-258129-c38q6xxs 90 4 hypothesized hypothesize VBD cord-258129-c38q6xxs 90 5 that that IN cord-258129-c38q6xxs 90 6 the the DT cord-258129-c38q6xxs 90 7 beneficial beneficial JJ cord-258129-c38q6xxs 90 8 effect effect NN cord-258129-c38q6xxs 90 9 of of IN cord-258129-c38q6xxs 90 10 aspirin aspirin NN cord-258129-c38q6xxs 90 11 on on IN cord-258129-c38q6xxs 90 12 infected infected JJ cord-258129-c38q6xxs 90 13 mice mouse NNS cord-258129-c38q6xxs 90 14 was be VBD cord-258129-c38q6xxs 90 15 a a DT cord-258129-c38q6xxs 90 16 result result NN cord-258129-c38q6xxs 90 17 of of IN cord-258129-c38q6xxs 90 18 the the DT cord-258129-c38q6xxs 90 19 production production NN cord-258129-c38q6xxs 90 20 of of IN cord-258129-c38q6xxs 90 21 15-epi 15-epi CD cord-258129-c38q6xxs 90 22 - - HYPH cord-258129-c38q6xxs 90 23 lipoxin lipoxin NNP cord-258129-c38q6xxs 90 24 A4 A4 NNP cord-258129-c38q6xxs 90 25 . . . cord-258129-c38q6xxs 91 1 This this DT cord-258129-c38q6xxs 91 2 may may MD cord-258129-c38q6xxs 91 3 represent represent VB cord-258129-c38q6xxs 91 4 a a DT cord-258129-c38q6xxs 91 5 new new JJ cord-258129-c38q6xxs 91 6 therapeutic therapeutic JJ cord-258129-c38q6xxs 91 7 strategy strategy NN cord-258129-c38q6xxs 91 8 in in IN cord-258129-c38q6xxs 91 9 the the DT cord-258129-c38q6xxs 91 10 acute acute JJ cord-258129-c38q6xxs 91 11 phase phase NN cord-258129-c38q6xxs 91 12 of of IN cord-258129-c38q6xxs 91 13 Chagas Chagas NNP cord-258129-c38q6xxs 91 14 disease disease NN cord-258129-c38q6xxs 91 15 . . . cord-258129-c38q6xxs 92 1 Wild wild JJ cord-258129-c38q6xxs 92 2 - - HYPH cord-258129-c38q6xxs 92 3 type type NN cord-258129-c38q6xxs 92 4 and and CC cord-258129-c38q6xxs 92 5 5-lipoxygenase 5-lipoxygenase CD cord-258129-c38q6xxs 92 6 - - HYPH cord-258129-c38q6xxs 92 7 deficient deficient JJ cord-258129-c38q6xxs 92 8 mice mouse NNS cord-258129-c38q6xxs 92 9 were be VBD cord-258129-c38q6xxs 92 10 infected infect VBN cord-258129-c38q6xxs 92 11 with with IN cord-258129-c38q6xxs 92 12 Plasmodium Plasmodium NNP cord-258129-c38q6xxs 92 13 berghei berghei NNP cord-258129-c38q6xxs 92 14 - - HYPH cord-258129-c38q6xxs 92 15 ANKA ANKA NNP cord-258129-c38q6xxs 92 16 in in IN cord-258129-c38q6xxs 92 17 a a DT cord-258129-c38q6xxs 92 18 model model NN cord-258129-c38q6xxs 92 19 of of IN cord-258129-c38q6xxs 92 20 cerebral cerebral JJ cord-258129-c38q6xxs 92 21 malaria malaria NN cord-258129-c38q6xxs 92 22 . . . cord-258129-c38q6xxs 93 1 24 24 CD cord-258129-c38q6xxs 93 2 Wild wild JJ cord-258129-c38q6xxs 93 3 - - HYPH cord-258129-c38q6xxs 93 4 type type NN cord-258129-c38q6xxs 93 5 mice mouse NNS cord-258129-c38q6xxs 93 6 enjoyed enjoy VBN cord-258129-c38q6xxs 93 7 significantly significantly RB cord-258129-c38q6xxs 93 8 increased increase VBN cord-258129-c38q6xxs 93 9 survival survival NN cord-258129-c38q6xxs 93 10 in in IN cord-258129-c38q6xxs 93 11 comparison comparison NN cord-258129-c38q6xxs 93 12 to to IN cord-258129-c38q6xxs 93 13 5-lipoxygenase 5-lipoxygenase CD cord-258129-c38q6xxs 93 14 - - HYPH cord-258129-c38q6xxs 93 15 deficient deficient JJ cord-258129-c38q6xxs 93 16 mice mouse NNS cord-258129-c38q6xxs 93 17 . . . cord-258129-c38q6xxs 94 1 Levels level NNS cord-258129-c38q6xxs 94 2 of of IN cord-258129-c38q6xxs 94 3 parasitaemia parasitaemia NN cord-258129-c38q6xxs 94 4 were be VBD cord-258129-c38q6xxs 94 5 similar similar JJ cord-258129-c38q6xxs 94 6 between between IN cord-258129-c38q6xxs 94 7 groups group NNS cord-258129-c38q6xxs 94 8 , , , cord-258129-c38q6xxs 94 9 but but CC cord-258129-c38q6xxs 94 10 lipoxin lipoxin NN cord-258129-c38q6xxs 94 11 - - HYPH cord-258129-c38q6xxs 94 12 deficient deficient JJ cord-258129-c38q6xxs 94 13 mice mouse NNS cord-258129-c38q6xxs 94 14 had have VBD cord-258129-c38q6xxs 94 15 an an DT cord-258129-c38q6xxs 94 16 increased increase VBN cord-258129-c38q6xxs 94 17 cerebral cerebral JJ cord-258129-c38q6xxs 94 18 parasite parasite NN cord-258129-c38q6xxs 94 19 burden burden NN cord-258129-c38q6xxs 94 20 after after IN cord-258129-c38q6xxs 94 21 5 5 CD cord-258129-c38q6xxs 94 22 days day NNS cord-258129-c38q6xxs 94 23 despite despite IN cord-258129-c38q6xxs 94 24 reduced reduce VBN cord-258129-c38q6xxs 94 25 cerebral cerebral JJ cord-258129-c38q6xxs 94 26 inflammation inflammation NN cord-258129-c38q6xxs 94 27 and and CC cord-258129-c38q6xxs 94 28 less less JJR cord-258129-c38q6xxs 94 29 CD8 CD8 NNP cord-258129-c38q6xxs 94 30 + + CC cord-258129-c38q6xxs 94 31 IFN IFN NNP cord-258129-c38q6xxs 94 32 - - HYPH cord-258129-c38q6xxs 94 33 c c NNP cord-258129-c38q6xxs 94 34 + + CC cord-258129-c38q6xxs 94 35 T t NN cord-258129-c38q6xxs 94 36 cells cell NNS cord-258129-c38q6xxs 94 37 in in IN cord-258129-c38q6xxs 94 38 brain brain NN cord-258129-c38q6xxs 94 39 tissue tissue NN cord-258129-c38q6xxs 94 40 . . . cord-258129-c38q6xxs 95 1 The the DT cord-258129-c38q6xxs 95 2 lipoxin lipoxin NN cord-258129-c38q6xxs 95 3 - - HYPH cord-258129-c38q6xxs 95 4 deficient deficient JJ cord-258129-c38q6xxs 95 5 mice mouse NNS cord-258129-c38q6xxs 95 6 were be VBD cord-258129-c38q6xxs 95 7 found find VBN cord-258129-c38q6xxs 95 8 to to TO cord-258129-c38q6xxs 95 9 have have VB cord-258129-c38q6xxs 95 10 higher high JJR cord-258129-c38q6xxs 95 11 serum serum NN cord-258129-c38q6xxs 95 12 levels level NNS cord-258129-c38q6xxs 95 13 of of IN cord-258129-c38q6xxs 95 14 IL-12 IL-12 NNP cord-258129-c38q6xxs 95 15 and and CC cord-258129-c38q6xxs 95 16 IFN IFN NNP cord-258129-c38q6xxs 95 17 - - HYPH cord-258129-c38q6xxs 95 18 c c NNP cord-258129-c38q6xxs 95 19 , , , cord-258129-c38q6xxs 95 20 both both DT cord-258129-c38q6xxs 95 21 of of IN cord-258129-c38q6xxs 95 22 which which WDT cord-258129-c38q6xxs 95 23 are be VBP cord-258129-c38q6xxs 95 24 associated associate VBN cord-258129-c38q6xxs 95 25 with with IN cord-258129-c38q6xxs 95 26 the the DT cord-258129-c38q6xxs 95 27 pathogenesis pathogenesis NN cord-258129-c38q6xxs 95 28 of of IN cord-258129-c38q6xxs 95 29 murine murine JJ cord-258129-c38q6xxs 95 30 cerebral cerebral JJ cord-258129-c38q6xxs 95 31 malaria malaria NN cord-258129-c38q6xxs 95 32 . . . cord-258129-c38q6xxs 96 1 Significantly significantly RB cord-258129-c38q6xxs 96 2 , , , cord-258129-c38q6xxs 96 3 treatment treatment NN cord-258129-c38q6xxs 96 4 with with IN cord-258129-c38q6xxs 96 5 15-epi 15-epi CD cord-258129-c38q6xxs 96 6 - - HYPH cord-258129-c38q6xxs 96 7 lipoxin lipoxin NNP cord-258129-c38q6xxs 96 8 A4 A4 NNP cord-258129-c38q6xxs 96 9 significantly significantly RB cord-258129-c38q6xxs 96 10 prolonged prolong VBD cord-258129-c38q6xxs 96 11 survival survival NN cord-258129-c38q6xxs 96 12 in in IN cord-258129-c38q6xxs 96 13 both both DT cord-258129-c38q6xxs 96 14 wild wild JJ cord-258129-c38q6xxs 96 15 - - HYPH cord-258129-c38q6xxs 96 16 type type NN cord-258129-c38q6xxs 96 17 and and CC cord-258129-c38q6xxs 96 18 lipoxindeficient lipoxindeficient NN cord-258129-c38q6xxs 96 19 mice mouse NNS cord-258129-c38q6xxs 96 20 , , , cord-258129-c38q6xxs 96 21 as as RB cord-258129-c38q6xxs 96 22 well well RB cord-258129-c38q6xxs 96 23 as as IN cord-258129-c38q6xxs 96 24 reducing reduce VBG cord-258129-c38q6xxs 96 25 expression expression NN cord-258129-c38q6xxs 96 26 of of IN cord-258129-c38q6xxs 96 27 IL-12 IL-12 NNP cord-258129-c38q6xxs 96 28 and and CC cord-258129-c38q6xxs 96 29 IFN IFN NNP cord-258129-c38q6xxs 96 30 - - HYPH cord-258129-c38q6xxs 96 31 c c NNP cord-258129-c38q6xxs 96 32 in in IN cord-258129-c38q6xxs 96 33 the the DT cord-258129-c38q6xxs 96 34 brain brain NN cord-258129-c38q6xxs 96 35 . . . cord-258129-c38q6xxs 97 1 The the DT cord-258129-c38q6xxs 97 2 mortality mortality NN cord-258129-c38q6xxs 97 3 rate rate NN cord-258129-c38q6xxs 97 4 did do VBD cord-258129-c38q6xxs 97 5 not not RB cord-258129-c38q6xxs 97 6 differ differ VB cord-258129-c38q6xxs 97 7 significantly significantly RB cord-258129-c38q6xxs 97 8 if if IN cord-258129-c38q6xxs 97 9 lipoxin lipoxin NNP cord-258129-c38q6xxs 97 10 was be VBD cord-258129-c38q6xxs 97 11 administered administer VBN cord-258129-c38q6xxs 97 12 on on IN cord-258129-c38q6xxs 97 13 the the DT cord-258129-c38q6xxs 97 14 day day NN cord-258129-c38q6xxs 97 15 of of IN cord-258129-c38q6xxs 97 16 infection infection NN cord-258129-c38q6xxs 97 17 or or CC cord-258129-c38q6xxs 97 18 3 3 CD cord-258129-c38q6xxs 97 19 days day NNS cord-258129-c38q6xxs 97 20 later later RB cord-258129-c38q6xxs 97 21 . . . cord-258129-c38q6xxs 98 1 Lipoxin Lipoxin NNP cord-258129-c38q6xxs 98 2 therefore therefore RB cord-258129-c38q6xxs 98 3 appears appear VBZ cord-258129-c38q6xxs 98 4 to to TO cord-258129-c38q6xxs 98 5 increase increase VB cord-258129-c38q6xxs 98 6 host host NN cord-258129-c38q6xxs 98 7 survival survival NN cord-258129-c38q6xxs 98 8 in in IN cord-258129-c38q6xxs 98 9 a a DT cord-258129-c38q6xxs 98 10 mouse mouse NN cord-258129-c38q6xxs 98 11 model model NN cord-258129-c38q6xxs 98 12 of of IN cord-258129-c38q6xxs 98 13 cerebral cerebral JJ cord-258129-c38q6xxs 98 14 malaria malaria NN cord-258129-c38q6xxs 98 15 by by IN cord-258129-c38q6xxs 98 16 limiting limit VBG cord-258129-c38q6xxs 98 17 inflammation inflammation NN cord-258129-c38q6xxs 98 18 , , , cord-258129-c38q6xxs 98 19 not not RB cord-258129-c38q6xxs 98 20 by by IN cord-258129-c38q6xxs 98 21 enhancing enhance VBG cord-258129-c38q6xxs 98 22 control control NN cord-258129-c38q6xxs 98 23 of of IN cord-258129-c38q6xxs 98 24 parasite parasite NN cord-258129-c38q6xxs 98 25 levels level NNS cord-258129-c38q6xxs 98 26 . . . cord-258129-c38q6xxs 99 1 Serhan Serhan NNP cord-258129-c38q6xxs 99 2 and and CC cord-258129-c38q6xxs 99 3 co co NNS cord-258129-c38q6xxs 99 4 - - NNS cord-258129-c38q6xxs 99 5 workers worker NNS cord-258129-c38q6xxs 99 6 used use VBD cord-258129-c38q6xxs 99 7 a a DT cord-258129-c38q6xxs 99 8 rabbit rabbit NN cord-258129-c38q6xxs 99 9 model model NN cord-258129-c38q6xxs 99 10 of of IN cord-258129-c38q6xxs 99 11 periodontitis periodontitis NN cord-258129-c38q6xxs 99 12 to to TO cord-258129-c38q6xxs 99 13 investigate investigate VB cord-258129-c38q6xxs 99 14 the the DT cord-258129-c38q6xxs 99 15 effects effect NNS cord-258129-c38q6xxs 99 16 of of IN cord-258129-c38q6xxs 99 17 lipoxin lipoxin NN cord-258129-c38q6xxs 99 18 in in IN cord-258129-c38q6xxs 99 19 this this DT cord-258129-c38q6xxs 99 20 infection infection NN cord-258129-c38q6xxs 99 21 . . . cord-258129-c38q6xxs 100 1 25 25 CD cord-258129-c38q6xxs 101 1 The the DT cord-258129-c38q6xxs 101 2 application application NN cord-258129-c38q6xxs 101 3 of of IN cord-258129-c38q6xxs 101 4 a a DT cord-258129-c38q6xxs 101 5 dental dental JJ cord-258129-c38q6xxs 101 6 ligature ligature NN cord-258129-c38q6xxs 101 7 plus plus CC cord-258129-c38q6xxs 101 8 Porphyromonas Porphyromonas NNP cord-258129-c38q6xxs 101 9 gingivalis gingivalis NNP cord-258129-c38q6xxs 101 10 resulted result VBD cord-258129-c38q6xxs 101 11 in in IN cord-258129-c38q6xxs 101 12 soft soft JJ cord-258129-c38q6xxs 101 13 tissue tissue NN cord-258129-c38q6xxs 101 14 loss loss NN cord-258129-c38q6xxs 101 15 , , , cord-258129-c38q6xxs 101 16 histological histological JJ cord-258129-c38q6xxs 101 17 ( ( -LRB- cord-258129-c38q6xxs 101 18 leucocyte leucocyte NNP cord-258129-c38q6xxs 101 19 infiltrates infiltrate VBZ cord-258129-c38q6xxs 101 20 ) ) -RRB- cord-258129-c38q6xxs 101 21 and and CC cord-258129-c38q6xxs 101 22 radiological radiological JJ cord-258129-c38q6xxs 101 23 ( ( -LRB- cord-258129-c38q6xxs 101 24 bone bone NN cord-258129-c38q6xxs 101 25 loss loss NN cord-258129-c38q6xxs 101 26 ) ) -RRB- cord-258129-c38q6xxs 101 27 features feature NNS cord-258129-c38q6xxs 101 28 of of IN cord-258129-c38q6xxs 101 29 periodontitis periodontitis NN cord-258129-c38q6xxs 101 30 in in IN cord-258129-c38q6xxs 101 31 wild wild JJ cord-258129-c38q6xxs 101 32 - - HYPH cord-258129-c38q6xxs 101 33 type type NN cord-258129-c38q6xxs 101 34 rabbits rabbit NNS cord-258129-c38q6xxs 101 35 . . . cord-258129-c38q6xxs 102 1 The the DT cord-258129-c38q6xxs 102 2 authors author NNS cord-258129-c38q6xxs 102 3 then then RB cord-258129-c38q6xxs 102 4 used use VBD cord-258129-c38q6xxs 102 5 a a DT cord-258129-c38q6xxs 102 6 transgenic transgenic JJ cord-258129-c38q6xxs 102 7 rabbit rabbit NN cord-258129-c38q6xxs 102 8 that that IN cord-258129-c38q6xxs 102 9 over over RB cord-258129-c38q6xxs 102 10 - - HYPH cord-258129-c38q6xxs 102 11 expresses express VBZ cord-258129-c38q6xxs 102 12 the the DT cord-258129-c38q6xxs 102 13 enzyme enzyme NN cord-258129-c38q6xxs 102 14 15-lipoxygenase 15-lipoxygenase CD cord-258129-c38q6xxs 102 15 , , , cord-258129-c38q6xxs 102 16 resulting result VBG cord-258129-c38q6xxs 102 17 in in IN cord-258129-c38q6xxs 102 18 threefold threefold NN cord-258129-c38q6xxs 102 19 to to IN cord-258129-c38q6xxs 102 20 fourfold fourfold JJ cord-258129-c38q6xxs 102 21 increased increase VBN cord-258129-c38q6xxs 102 22 lipoxin lipoxin NNP cord-258129-c38q6xxs 102 23 production production NN cord-258129-c38q6xxs 102 24 . . . cord-258129-c38q6xxs 103 1 In in IN cord-258129-c38q6xxs 103 2 these these DT cord-258129-c38q6xxs 103 3 transgenic transgenic JJ cord-258129-c38q6xxs 103 4 animals animal NNS cord-258129-c38q6xxs 103 5 , , , cord-258129-c38q6xxs 103 6 following follow VBG cord-258129-c38q6xxs 103 7 the the DT cord-258129-c38q6xxs 103 8 same same JJ cord-258129-c38q6xxs 103 9 procedure procedure NN cord-258129-c38q6xxs 103 10 to to TO cord-258129-c38q6xxs 103 11 establish establish VB cord-258129-c38q6xxs 103 12 periodontitis periodontitis NN cord-258129-c38q6xxs 103 13 , , , cord-258129-c38q6xxs 103 14 none none NN cord-258129-c38q6xxs 103 15 of of IN cord-258129-c38q6xxs 103 16 the the DT cord-258129-c38q6xxs 103 17 clinical clinical JJ cord-258129-c38q6xxs 103 18 , , , cord-258129-c38q6xxs 103 19 histological histological JJ cord-258129-c38q6xxs 103 20 or or CC cord-258129-c38q6xxs 103 21 radiographic radiographic JJ cord-258129-c38q6xxs 103 22 features feature NNS cord-258129-c38q6xxs 103 23 were be VBD cord-258129-c38q6xxs 103 24 found find VBN cord-258129-c38q6xxs 103 25 . . . cord-258129-c38q6xxs 104 1 In in IN cord-258129-c38q6xxs 104 2 the the DT cord-258129-c38q6xxs 104 3 wild wild JJ cord-258129-c38q6xxs 104 4 - - HYPH cord-258129-c38q6xxs 104 5 type type NN cord-258129-c38q6xxs 104 6 animals animal NNS cord-258129-c38q6xxs 104 7 , , , cord-258129-c38q6xxs 104 8 bone bone NN cord-258129-c38q6xxs 104 9 loss loss NN cord-258129-c38q6xxs 104 10 could could MD cord-258129-c38q6xxs 104 11 be be VB cord-258129-c38q6xxs 104 12 prevented prevent VBN cord-258129-c38q6xxs 104 13 by by IN cord-258129-c38q6xxs 104 14 the the DT cord-258129-c38q6xxs 104 15 administration administration NN cord-258129-c38q6xxs 104 16 of of IN cord-258129-c38q6xxs 104 17 intravenous intravenous NNP cord-258129-c38q6xxs 104 18 metronidazole metronidazole NNP cord-258129-c38q6xxs 104 19 , , , cord-258129-c38q6xxs 104 20 confirming confirm VBG cord-258129-c38q6xxs 104 21 that that IN cord-258129-c38q6xxs 104 22 P. P. NNP cord-258129-c38q6xxs 104 23 gingivalis gingivalis NNP cord-258129-c38q6xxs 104 24 infection infection NN cord-258129-c38q6xxs 104 25 was be VBD cord-258129-c38q6xxs 104 26 responsible responsible JJ cord-258129-c38q6xxs 104 27 for for IN cord-258129-c38q6xxs 104 28 the the DT cord-258129-c38q6xxs 104 29 features feature NNS cord-258129-c38q6xxs 104 30 seen see VBN cord-258129-c38q6xxs 104 31 . . . cord-258129-c38q6xxs 105 1 Wild wild JJ cord-258129-c38q6xxs 105 2 - - HYPH cord-258129-c38q6xxs 105 3 type type NN cord-258129-c38q6xxs 105 4 rabbits rabbit NNS cord-258129-c38q6xxs 105 5 subject subject JJ cord-258129-c38q6xxs 105 6 to to IN cord-258129-c38q6xxs 105 7 periodontitis periodontitis NN cord-258129-c38q6xxs 105 8 induction induction NN cord-258129-c38q6xxs 105 9 were be VBD cord-258129-c38q6xxs 105 10 then then RB cord-258129-c38q6xxs 105 11 administered administer VBN cord-258129-c38q6xxs 105 12 a a DT cord-258129-c38q6xxs 105 13 topical topical JJ cord-258129-c38q6xxs 105 14 lipoxin lipoxin NN cord-258129-c38q6xxs 105 15 analogue analogue NN cord-258129-c38q6xxs 105 16 and and CC cord-258129-c38q6xxs 105 17 this this DT cord-258129-c38q6xxs 105 18 protected protect VBD cord-258129-c38q6xxs 105 19 the the DT cord-258129-c38q6xxs 105 20 animals animal NNS cord-258129-c38q6xxs 105 21 from from IN cord-258129-c38q6xxs 105 22 gross gross JJ cord-258129-c38q6xxs 105 23 soft soft JJ cord-258129-c38q6xxs 105 24 tissue tissue NN cord-258129-c38q6xxs 105 25 destruction destruction NN cord-258129-c38q6xxs 105 26 , , , cord-258129-c38q6xxs 105 27 leucocyte leucocyte NNP cord-258129-c38q6xxs 105 28 accumulation accumulation NN cord-258129-c38q6xxs 105 29 and and CC cord-258129-c38q6xxs 105 30 bone bone NN cord-258129-c38q6xxs 105 31 loss loss NN cord-258129-c38q6xxs 105 32 . . . cord-258129-c38q6xxs 106 1 Periodontitis Periodontitis NNP cord-258129-c38q6xxs 106 2 is be VBZ cord-258129-c38q6xxs 106 3 an an DT cord-258129-c38q6xxs 106 4 infectious infectious JJ cord-258129-c38q6xxs 106 5 disease disease NN cord-258129-c38q6xxs 106 6 , , , cord-258129-c38q6xxs 106 7 though though IN cord-258129-c38q6xxs 106 8 the the DT cord-258129-c38q6xxs 106 9 tissue tissue NN cord-258129-c38q6xxs 106 10 damage damage NN cord-258129-c38q6xxs 106 11 characteristic characteristic NN cord-258129-c38q6xxs 106 12 of of IN cord-258129-c38q6xxs 106 13 the the DT cord-258129-c38q6xxs 106 14 condition condition NN cord-258129-c38q6xxs 106 15 is be VBZ cord-258129-c38q6xxs 106 16 thought think VBN cord-258129-c38q6xxs 106 17 to to TO cord-258129-c38q6xxs 106 18 be be VB cord-258129-c38q6xxs 106 19 driven drive VBN cord-258129-c38q6xxs 106 20 by by IN cord-258129-c38q6xxs 106 21 an an DT cord-258129-c38q6xxs 106 22 aberrant aberrant JJ cord-258129-c38q6xxs 106 23 host host NN cord-258129-c38q6xxs 106 24 response response NN cord-258129-c38q6xxs 106 25 to to IN cord-258129-c38q6xxs 106 26 infection infection NN cord-258129-c38q6xxs 106 27 . . . cord-258129-c38q6xxs 107 1 26 26 CD cord-258129-c38q6xxs 108 1 In in IN cord-258129-c38q6xxs 108 2 this this DT cord-258129-c38q6xxs 108 3 set set NN cord-258129-c38q6xxs 108 4 of of IN cord-258129-c38q6xxs 108 5 experiments experiment NNS cord-258129-c38q6xxs 108 6 , , , cord-258129-c38q6xxs 108 7 Serhan Serhan NNP cord-258129-c38q6xxs 108 8 et et NNP cord-258129-c38q6xxs 108 9 al al NNP cord-258129-c38q6xxs 108 10 . . . cord-258129-c38q6xxs 109 1 demonstrate demonstrate VB cord-258129-c38q6xxs 109 2 that that IN cord-258129-c38q6xxs 109 3 lipoxin lipoxin NNP cord-258129-c38q6xxs 109 4 has have VBZ cord-258129-c38q6xxs 109 5 a a DT cord-258129-c38q6xxs 109 6 role role NN cord-258129-c38q6xxs 109 7 in in IN cord-258129-c38q6xxs 109 8 curbing curb VBG cord-258129-c38q6xxs 109 9 this this DT cord-258129-c38q6xxs 109 10 excessive excessive JJ cord-258129-c38q6xxs 109 11 response response NN cord-258129-c38q6xxs 109 12 and and CC cord-258129-c38q6xxs 109 13 that that IN cord-258129-c38q6xxs 109 14 this this DT cord-258129-c38q6xxs 109 15 has have VBZ cord-258129-c38q6xxs 109 16 a a DT cord-258129-c38q6xxs 109 17 protective protective JJ cord-258129-c38q6xxs 109 18 effect effect NN cord-258129-c38q6xxs 109 19 in in IN cord-258129-c38q6xxs 109 20 vivo vivo NN cord-258129-c38q6xxs 109 21 . . . cord-258129-c38q6xxs 110 1 By by IN cord-258129-c38q6xxs 110 2 performing perform VBG cord-258129-c38q6xxs 110 3 transcriptional transcriptional JJ cord-258129-c38q6xxs 110 4 profiling profiling NN cord-258129-c38q6xxs 110 5 of of IN cord-258129-c38q6xxs 110 6 model model JJ cord-258129-c38q6xxs 110 7 epithelial epithelial JJ cord-258129-c38q6xxs 110 8 cells cell NNS cord-258129-c38q6xxs 110 9 exposed expose VBN cord-258129-c38q6xxs 110 10 to to IN cord-258129-c38q6xxs 110 11 lipoxin lipoxin NNP cord-258129-c38q6xxs 110 12 , , , cord-258129-c38q6xxs 110 13 Canny Canny NNP cord-258129-c38q6xxs 110 14 et et FW cord-258129-c38q6xxs 110 15 al al NNP cord-258129-c38q6xxs 110 16 . . . cord-258129-c38q6xxs 111 1 27 27 CD cord-258129-c38q6xxs 111 2 found find VBD cord-258129-c38q6xxs 111 3 that that IN cord-258129-c38q6xxs 111 4 lipoxin lipoxin NNP cord-258129-c38q6xxs 111 5 up up RB cord-258129-c38q6xxs 111 6 - - HYPH cord-258129-c38q6xxs 111 7 regulated regulate VBD cord-258129-c38q6xxs 111 8 the the DT cord-258129-c38q6xxs 111 9 expression expression NN cord-258129-c38q6xxs 111 10 of of IN cord-258129-c38q6xxs 111 11 bactericidal bactericidal JJ cord-258129-c38q6xxs 111 12 / / SYM cord-258129-c38q6xxs 111 13 perme perme NN cord-258129-c38q6xxs 111 14 - - HYPH cord-258129-c38q6xxs 111 15 ability ability NN cord-258129-c38q6xxs 111 16 - - HYPH cord-258129-c38q6xxs 111 17 increasing increase VBG cord-258129-c38q6xxs 111 18 protein protein NN cord-258129-c38q6xxs 111 19 ( ( -LRB- cord-258129-c38q6xxs 111 20 BPI BPI NNP cord-258129-c38q6xxs 111 21 ) ) -RRB- cord-258129-c38q6xxs 111 22 . . . cord-258129-c38q6xxs 112 1 BPI BPI NNP cord-258129-c38q6xxs 112 2 is be VBZ cord-258129-c38q6xxs 112 3 an an DT cord-258129-c38q6xxs 112 4 innate innate JJ cord-258129-c38q6xxs 112 5 immune immune JJ cord-258129-c38q6xxs 112 6 defence defence NN cord-258129-c38q6xxs 112 7 molecule molecule NN cord-258129-c38q6xxs 112 8 that that WDT cord-258129-c38q6xxs 112 9 is be VBZ cord-258129-c38q6xxs 112 10 active active JJ cord-258129-c38q6xxs 112 11 against against IN cord-258129-c38q6xxs 112 12 Gram Gram NNP cord-258129-c38q6xxs 112 13 negative negative JJ cord-258129-c38q6xxs 112 14 bacteria bacteria NNS cord-258129-c38q6xxs 112 15 , , , cord-258129-c38q6xxs 112 16 through through IN cord-258129-c38q6xxs 112 17 bactericidal bactericidal JJ cord-258129-c38q6xxs 112 18 effects effect NNS cord-258129-c38q6xxs 112 19 on on IN cord-258129-c38q6xxs 112 20 bacterial bacterial JJ cord-258129-c38q6xxs 112 21 cell cell NN cord-258129-c38q6xxs 112 22 membranes membrane NNS cord-258129-c38q6xxs 112 23 , , , cord-258129-c38q6xxs 112 24 neutralization neutralization NN cord-258129-c38q6xxs 112 25 of of IN cord-258129-c38q6xxs 112 26 lipopolysaccharide lipopolysaccharide NN cord-258129-c38q6xxs 112 27 and and CC cord-258129-c38q6xxs 112 28 as as IN cord-258129-c38q6xxs 112 29 an an DT cord-258129-c38q6xxs 112 30 opsonin opsonin NNS cord-258129-c38q6xxs 112 31 . . . cord-258129-c38q6xxs 113 1 This this DT cord-258129-c38q6xxs 113 2 was be VBD cord-258129-c38q6xxs 113 3 then then RB cord-258129-c38q6xxs 113 4 confirmed confirm VBN cord-258129-c38q6xxs 113 5 in in IN cord-258129-c38q6xxs 113 6 four four CD cord-258129-c38q6xxs 113 7 other other JJ cord-258129-c38q6xxs 113 8 epithelial epithelial JJ cord-258129-c38q6xxs 113 9 cell cell NN cord-258129-c38q6xxs 113 10 lines line NNS cord-258129-c38q6xxs 113 11 ( ( -LRB- cord-258129-c38q6xxs 113 12 OKF6 OKF6 NNP cord-258129-c38q6xxs 113 13 , , , cord-258129-c38q6xxs 113 14 T84 T84 NNP cord-258129-c38q6xxs 113 15 , , , cord-258129-c38q6xxs 113 16 Caco2 caco2 JJ cord-258129-c38q6xxs 113 17 and and CC cord-258129-c38q6xxs 113 18 pulmonary pulmonary JJ cord-258129-c38q6xxs 113 19 epithelial epithelial JJ cord-258129-c38q6xxs 113 20 cells cell NNS cord-258129-c38q6xxs 113 21 A549 a549 JJ cord-258129-c38q6xxs 113 22 ) ) -RRB- cord-258129-c38q6xxs 113 23 . . . cord-258129-c38q6xxs 114 1 Building build VBG cord-258129-c38q6xxs 114 2 on on IN cord-258129-c38q6xxs 114 3 the the DT cord-258129-c38q6xxs 114 4 known known JJ cord-258129-c38q6xxs 114 5 bactericidal bactericidal JJ cord-258129-c38q6xxs 114 6 effect effect NN cord-258129-c38q6xxs 114 7 of of IN cord-258129-c38q6xxs 114 8 epithelium epithelium NN cord-258129-c38q6xxs 114 9 - - HYPH cord-258129-c38q6xxs 114 10 derived derive VBN cord-258129-c38q6xxs 114 11 BPI BPI NNP cord-258129-c38q6xxs 114 12 on on IN cord-258129-c38q6xxs 114 13 Gram gram NN cord-258129-c38q6xxs 114 14 - - HYPH cord-258129-c38q6xxs 114 15 negative negative JJ cord-258129-c38q6xxs 114 16 bacteria bacteria NNS cord-258129-c38q6xxs 114 17 , , , cord-258129-c38q6xxs 114 18 the the DT cord-258129-c38q6xxs 114 19 authors author NNS cord-258129-c38q6xxs 114 20 sought seek VBD cord-258129-c38q6xxs 114 21 to to TO cord-258129-c38q6xxs 114 22 examine examine VB cord-258129-c38q6xxs 114 23 the the DT cord-258129-c38q6xxs 114 24 effect effect NN cord-258129-c38q6xxs 114 25 of of IN cord-258129-c38q6xxs 114 26 lipoxin lipoxin NNP cord-258129-c38q6xxs 114 27 on on IN cord-258129-c38q6xxs 114 28 epithelial epithelial JJ cord-258129-c38q6xxs 114 29 killing killing NN cord-258129-c38q6xxs 114 30 of of IN cord-258129-c38q6xxs 114 31 Salmonella Salmonella NNP cord-258129-c38q6xxs 114 32 typhimurium typhimurium NN cord-258129-c38q6xxs 114 33 . . . cord-258129-c38q6xxs 115 1 Epithelial epithelial JJ cord-258129-c38q6xxs 115 2 cell cell NN cord-258129-c38q6xxs 115 3 culture culture NN cord-258129-c38q6xxs 115 4 was be VBD cord-258129-c38q6xxs 115 5 pre pre VBN cord-258129-c38q6xxs 115 6 - - VBN cord-258129-c38q6xxs 115 7 exposed expose VBN cord-258129-c38q6xxs 115 8 to to IN cord-258129-c38q6xxs 115 9 lipoxin lipoxin VB cord-258129-c38q6xxs 115 10 analogue analogue NN cord-258129-c38q6xxs 115 11 and and CC cord-258129-c38q6xxs 115 12 then then RB cord-258129-c38q6xxs 115 13 incubated incubate VBN cord-258129-c38q6xxs 115 14 with with IN cord-258129-c38q6xxs 115 15 S. S. NNP cord-258129-c38q6xxs 115 16 typhimurium typhimurium NN cord-258129-c38q6xxs 115 17 . . . cord-258129-c38q6xxs 116 1 This this DT cord-258129-c38q6xxs 116 2 resulted result VBD cord-258129-c38q6xxs 116 3 in in IN cord-258129-c38q6xxs 116 4 concentration concentration NN cord-258129-c38q6xxs 116 5 - - HYPH cord-258129-c38q6xxs 116 6 dependent dependent JJ cord-258129-c38q6xxs 116 7 increased increase VBN cord-258129-c38q6xxs 116 8 bacterial bacterial JJ cord-258129-c38q6xxs 116 9 killing killing NN cord-258129-c38q6xxs 116 10 compared compare VBN cord-258129-c38q6xxs 116 11 with with IN cord-258129-c38q6xxs 116 12 non non JJ cord-258129-c38q6xxs 116 13 - - JJ cord-258129-c38q6xxs 116 14 pre pre JJ cord-258129-c38q6xxs 116 15 - - JJ cord-258129-c38q6xxs 116 16 treated treat VBN cord-258129-c38q6xxs 116 17 cultures culture NNS cord-258129-c38q6xxs 116 18 . . . cord-258129-c38q6xxs 117 1 This this DT cord-258129-c38q6xxs 117 2 enhanced enhanced JJ cord-258129-c38q6xxs 117 3 bactericidal bactericidal JJ cord-258129-c38q6xxs 117 4 activity activity NN cord-258129-c38q6xxs 117 5 could could MD cord-258129-c38q6xxs 117 6 be be VB cord-258129-c38q6xxs 117 7 significantly significantly RB cord-258129-c38q6xxs 117 8 inhibited inhibit VBN cord-258129-c38q6xxs 117 9 by by IN cord-258129-c38q6xxs 117 10 the the DT cord-258129-c38q6xxs 117 11 addition addition NN cord-258129-c38q6xxs 117 12 of of IN cord-258129-c38q6xxs 117 13 anti anti JJ cord-258129-c38q6xxs 117 14 - - JJ cord-258129-c38q6xxs 117 15 BPI BPI NNP cord-258129-c38q6xxs 117 16 , , , cord-258129-c38q6xxs 117 17 indicating indicate VBG cord-258129-c38q6xxs 117 18 that that IN cord-258129-c38q6xxs 117 19 induction induction NN cord-258129-c38q6xxs 117 20 of of IN cord-258129-c38q6xxs 117 21 BPI BPI NNP cord-258129-c38q6xxs 117 22 was be VBD cord-258129-c38q6xxs 117 23 largely largely RB cord-258129-c38q6xxs 117 24 responsible responsible JJ cord-258129-c38q6xxs 117 25 for for IN cord-258129-c38q6xxs 117 26 this this DT cord-258129-c38q6xxs 117 27 lipoxin lipoxin NN cord-258129-c38q6xxs 117 28 - - HYPH cord-258129-c38q6xxs 117 29 mediated mediate VBN cord-258129-c38q6xxs 117 30 enhanced enhance VBN cord-258129-c38q6xxs 117 31 killing killing NN cord-258129-c38q6xxs 117 32 of of IN cord-258129-c38q6xxs 117 33 S. S. NNP cord-258129-c38q6xxs 117 34 typhimurium typhimurium NN cord-258129-c38q6xxs 117 35 . . . cord-258129-c38q6xxs 118 1 Interestingly interestingly RB cord-258129-c38q6xxs 118 2 , , , cord-258129-c38q6xxs 118 3 in in IN cord-258129-c38q6xxs 118 4 a a DT cord-258129-c38q6xxs 118 5 mouse mouse NN cord-258129-c38q6xxs 118 6 model model NN cord-258129-c38q6xxs 118 7 of of IN cord-258129-c38q6xxs 118 8 ( ( -LRB- cord-258129-c38q6xxs 118 9 noninfectious noninfectious JJ cord-258129-c38q6xxs 118 10 ) ) -RRB- cord-258129-c38q6xxs 118 11 dextran dextran NN cord-258129-c38q6xxs 118 12 sodium sodium NN cord-258129-c38q6xxs 118 13 - - HYPH cord-258129-c38q6xxs 118 14 sulphate sulphate NN cord-258129-c38q6xxs 118 15 - - HYPH cord-258129-c38q6xxs 118 16 induced induce VBN cord-258129-c38q6xxs 118 17 colitis colitis NN cord-258129-c38q6xxs 118 18 , , , cord-258129-c38q6xxs 118 19 oral oral JJ cord-258129-c38q6xxs 118 20 administration administration NN cord-258129-c38q6xxs 118 21 of of IN cord-258129-c38q6xxs 118 22 lipoxin lipoxin NNP cord-258129-c38q6xxs 118 23 analogue analogue NNP cord-258129-c38q6xxs 118 24 reduced reduce VBN cord-258129-c38q6xxs 118 25 weight weight NN cord-258129-c38q6xxs 118 26 loss loss NN cord-258129-c38q6xxs 118 27 , , , cord-258129-c38q6xxs 118 28 passage passage NN cord-258129-c38q6xxs 118 29 of of IN cord-258129-c38q6xxs 118 30 blood blood NN cord-258129-c38q6xxs 118 31 per per IN cord-258129-c38q6xxs 118 32 rectum rectum NN cord-258129-c38q6xxs 118 33 and and CC cord-258129-c38q6xxs 118 34 mortality mortality NN cord-258129-c38q6xxs 118 35 , , , cord-258129-c38q6xxs 118 36 affirming affirm VBG cord-258129-c38q6xxs 118 37 its -PRON- PRP$ cord-258129-c38q6xxs 118 38 role role NN cord-258129-c38q6xxs 118 39 in in IN cord-258129-c38q6xxs 118 40 gastrointestinal gastrointestinal JJ cord-258129-c38q6xxs 118 41 mucosal mucosal JJ cord-258129-c38q6xxs 118 42 inflammatory inflammatory JJ cord-258129-c38q6xxs 118 43 conditions condition NNS cord-258129-c38q6xxs 118 44 . . . cord-258129-c38q6xxs 119 1 28 28 CD cord-258129-c38q6xxs 119 2 _SP cord-258129-c38q6xxs 119 3 Caecal Caecal NNP cord-258129-c38q6xxs 119 4 ligation ligation NN cord-258129-c38q6xxs 119 5 and and CC cord-258129-c38q6xxs 119 6 puncture puncture NN cord-258129-c38q6xxs 119 7 in in IN cord-258129-c38q6xxs 119 8 mice mouse NNS cord-258129-c38q6xxs 119 9 establishes establish VBZ cord-258129-c38q6xxs 119 10 microbial microbial JJ cord-258129-c38q6xxs 119 11 sepsis sepsis NN cord-258129-c38q6xxs 119 12 that that WDT cord-258129-c38q6xxs 119 13 is be VBZ cord-258129-c38q6xxs 119 14 considered consider VBN cord-258129-c38q6xxs 119 15 similar similar JJ cord-258129-c38q6xxs 119 16 to to IN cord-258129-c38q6xxs 119 17 the the DT cord-258129-c38q6xxs 119 18 pathophysiology pathophysiology NN cord-258129-c38q6xxs 119 19 of of IN cord-258129-c38q6xxs 119 20 sepsis sepsis NN cord-258129-c38q6xxs 119 21 in in IN cord-258129-c38q6xxs 119 22 humans human NNS cord-258129-c38q6xxs 119 23 . . . cord-258129-c38q6xxs 120 1 29 29 CD cord-258129-c38q6xxs 121 1 In in IN cord-258129-c38q6xxs 121 2 this this DT cord-258129-c38q6xxs 121 3 model model NN cord-258129-c38q6xxs 121 4 , , , cord-258129-c38q6xxs 121 5 in in IN cord-258129-c38q6xxs 121 6 comparison comparison NN cord-258129-c38q6xxs 121 7 to to IN cord-258129-c38q6xxs 121 8 a a DT cord-258129-c38q6xxs 121 9 control control NN cord-258129-c38q6xxs 121 10 treatment treatment NN cord-258129-c38q6xxs 121 11 , , , cord-258129-c38q6xxs 121 12 intravenous intravenous JJ cord-258129-c38q6xxs 121 13 administration administration NN cord-258129-c38q6xxs 121 14 of of IN cord-258129-c38q6xxs 121 15 resolvin resolvin NNP cord-258129-c38q6xxs 121 16 D2 D2 NNP cord-258129-c38q6xxs 121 17 reduced reduce VBD cord-258129-c38q6xxs 121 18 the the DT cord-258129-c38q6xxs 121 19 viable viable JJ cord-258129-c38q6xxs 121 20 bacterial bacterial JJ cord-258129-c38q6xxs 121 21 load load NN cord-258129-c38q6xxs 121 22 in in IN cord-258129-c38q6xxs 121 23 blood blood NN cord-258129-c38q6xxs 121 24 and and CC cord-258129-c38q6xxs 121 25 peritoneal peritoneal JJ cord-258129-c38q6xxs 121 26 exudates exudate NNS cord-258129-c38q6xxs 121 27 ( ( -LRB- cord-258129-c38q6xxs 121 28 in in IN cord-258129-c38q6xxs 121 29 the the DT cord-258129-c38q6xxs 121 30 absence absence NN cord-258129-c38q6xxs 121 31 of of IN cord-258129-c38q6xxs 121 32 direct direct JJ cord-258129-c38q6xxs 121 33 antibacterial antibacterial JJ cord-258129-c38q6xxs 121 34 effects effect NNS cord-258129-c38q6xxs 121 35 ) ) -RRB- cord-258129-c38q6xxs 121 36 and and CC cord-258129-c38q6xxs 121 37 reduced reduce VBN cord-258129-c38q6xxs 121 38 neutrophil neutrophil NN cord-258129-c38q6xxs 121 39 migration migration NN cord-258129-c38q6xxs 121 40 into into IN cord-258129-c38q6xxs 121 41 the the DT cord-258129-c38q6xxs 121 42 peritoneal peritoneal JJ cord-258129-c38q6xxs 121 43 cavity cavity NN cord-258129-c38q6xxs 121 44 . . . cord-258129-c38q6xxs 122 1 In in IN cord-258129-c38q6xxs 122 2 addition addition NN cord-258129-c38q6xxs 122 3 , , , cord-258129-c38q6xxs 122 4 histological histological JJ cord-258129-c38q6xxs 122 5 evidence evidence NN cord-258129-c38q6xxs 122 6 was be VBD cord-258129-c38q6xxs 122 7 seen see VBN cord-258129-c38q6xxs 122 8 of of IN cord-258129-c38q6xxs 122 9 enhanced enhance VBN cord-258129-c38q6xxs 122 10 phagocytosis phagocytosis NN cord-258129-c38q6xxs 122 11 of of IN cord-258129-c38q6xxs 122 12 bacteria bacteria NNS cord-258129-c38q6xxs 122 13 in in IN cord-258129-c38q6xxs 122 14 inguinal inguinal JJ cord-258129-c38q6xxs 122 15 lymph lymph NN cord-258129-c38q6xxs 122 16 nodes node NNS cord-258129-c38q6xxs 122 17 and and CC cord-258129-c38q6xxs 122 18 in in IN cord-258129-c38q6xxs 122 19 vitro vitro FW cord-258129-c38q6xxs 122 20 , , , cord-258129-c38q6xxs 122 21 incubation incubation NN cord-258129-c38q6xxs 122 22 with with IN cord-258129-c38q6xxs 122 23 resolvin resolvin NNP cord-258129-c38q6xxs 122 24 D2 D2 NNP cord-258129-c38q6xxs 122 25 enhanced enhance VBN cord-258129-c38q6xxs 122 26 zymosan zymosan NNP cord-258129-c38q6xxs 122 27 phagocytosis phagocytosis NN cord-258129-c38q6xxs 122 28 by by IN cord-258129-c38q6xxs 122 29 macrophages macrophage NNS cord-258129-c38q6xxs 122 30 obtained obtain VBN cord-258129-c38q6xxs 122 31 from from IN cord-258129-c38q6xxs 122 32 the the DT cord-258129-c38q6xxs 122 33 peritoneum peritoneum NN cord-258129-c38q6xxs 122 34 of of IN cord-258129-c38q6xxs 122 35 resolvin resolvin JJ cord-258129-c38q6xxs 122 36 - - HYPH cord-258129-c38q6xxs 122 37 naive naive JJ cord-258129-c38q6xxs 122 38 mice mouse NNS cord-258129-c38q6xxs 122 39 . . . cord-258129-c38q6xxs 123 1 When when WRB cord-258129-c38q6xxs 123 2 incubated incubate VBN cord-258129-c38q6xxs 123 3 with with IN cord-258129-c38q6xxs 123 4 resolvin resolvin NNP cord-258129-c38q6xxs 123 5 D2 D2 NNP cord-258129-c38q6xxs 123 6 , , , cord-258129-c38q6xxs 123 7 human human JJ cord-258129-c38q6xxs 123 8 neutrophils neutrophil NNS cord-258129-c38q6xxs 123 9 demonstrated demonstrate VBD cord-258129-c38q6xxs 123 10 enhanced enhanced JJ cord-258129-c38q6xxs 123 11 phagocytosis phagocytosis NN cord-258129-c38q6xxs 123 12 of of IN cord-258129-c38q6xxs 123 13 Escherichia Escherichia NNP cord-258129-c38q6xxs 123 14 coli coli NNS cord-258129-c38q6xxs 123 15 and and CC cord-258129-c38q6xxs 123 16 also also RB cord-258129-c38q6xxs 123 17 increased increase VBN cord-258129-c38q6xxs 123 18 intracellular intracellular JJ cord-258129-c38q6xxs 123 19 production production NN cord-258129-c38q6xxs 123 20 of of IN cord-258129-c38q6xxs 123 21 reactive reactive JJ cord-258129-c38q6xxs 123 22 oxygen oxygen NN cord-258129-c38q6xxs 123 23 species specie NNS cord-258129-c38q6xxs 123 24 . . . cord-258129-c38q6xxs 124 1 Furthermore furthermore RB cord-258129-c38q6xxs 124 2 , , , cord-258129-c38q6xxs 124 3 plasma plasma NN cord-258129-c38q6xxs 124 4 levels level NNS cord-258129-c38q6xxs 124 5 of of IN cord-258129-c38q6xxs 124 6 pro pro JJ cord-258129-c38q6xxs 124 7 - - JJ cord-258129-c38q6xxs 124 8 inflammatory inflammatory JJ cord-258129-c38q6xxs 124 9 cytokines cytokine NNS cord-258129-c38q6xxs 124 10 ( ( -LRB- cord-258129-c38q6xxs 124 11 IL-6 IL-6 NNP cord-258129-c38q6xxs 124 12 , , , cord-258129-c38q6xxs 124 13 IL-1b IL-1b NNP cord-258129-c38q6xxs 124 14 , , , cord-258129-c38q6xxs 124 15 IL-23 IL-23 NNP cord-258129-c38q6xxs 124 16 and and CC cord-258129-c38q6xxs 124 17 TNF TNF NNP cord-258129-c38q6xxs 124 18 - - HYPH cord-258129-c38q6xxs 124 19 a a NN cord-258129-c38q6xxs 124 20 ) ) -RRB- cord-258129-c38q6xxs 124 21 were be VBD cord-258129-c38q6xxs 124 22 reduced reduce VBN cord-258129-c38q6xxs 124 23 in in IN cord-258129-c38q6xxs 124 24 resolvin resolvin NNP cord-258129-c38q6xxs 124 25 D2treated d2treated JJ cord-258129-c38q6xxs 124 26 mice mouse NNS cord-258129-c38q6xxs 124 27 . . . cord-258129-c38q6xxs 125 1 Importantly importantly RB cord-258129-c38q6xxs 125 2 , , , cord-258129-c38q6xxs 125 3 the the DT cord-258129-c38q6xxs 125 4 effect effect NN cord-258129-c38q6xxs 125 5 of of IN cord-258129-c38q6xxs 125 6 these these DT cord-258129-c38q6xxs 125 7 pro pro JJ cord-258129-c38q6xxs 125 8 - - JJ cord-258129-c38q6xxs 125 9 resolution resolution JJ cord-258129-c38q6xxs 125 10 actions action NNS cord-258129-c38q6xxs 125 11 of of IN cord-258129-c38q6xxs 125 12 resolvin resolvin NNP cord-258129-c38q6xxs 125 13 was be VBD cord-258129-c38q6xxs 125 14 to to TO cord-258129-c38q6xxs 125 15 increase increase VB cord-258129-c38q6xxs 125 16 survival survival NN cord-258129-c38q6xxs 125 17 from from IN cord-258129-c38q6xxs 125 18 sepsis sepsis NN cord-258129-c38q6xxs 125 19 in in IN cord-258129-c38q6xxs 125 20 this this DT cord-258129-c38q6xxs 125 21 mouse mouse NN cord-258129-c38q6xxs 125 22 model model NN cord-258129-c38q6xxs 125 23 . . . cord-258129-c38q6xxs 126 1 Chiang Chiang NNP cord-258129-c38q6xxs 126 2 et et NNP cord-258129-c38q6xxs 126 3 al al NNP cord-258129-c38q6xxs 126 4 . . . cord-258129-c38q6xxs 127 1 30 30 CD cord-258129-c38q6xxs 127 2 investigated investigate VBD cord-258129-c38q6xxs 127 3 the the DT cord-258129-c38q6xxs 127 4 effects effect NNS cord-258129-c38q6xxs 127 5 of of IN cord-258129-c38q6xxs 127 6 resolvin resolvin NNP cord-258129-c38q6xxs 127 7 using use VBG cord-258129-c38q6xxs 127 8 a a DT cord-258129-c38q6xxs 127 9 mouse mouse NN cord-258129-c38q6xxs 127 10 model model NN cord-258129-c38q6xxs 127 11 of of IN cord-258129-c38q6xxs 127 12 E. E. NNP cord-258129-c38q6xxs 127 13 coli coli NNS cord-258129-c38q6xxs 127 14 peritonitis peritonitis NN cord-258129-c38q6xxs 127 15 , , , cord-258129-c38q6xxs 127 16 involving involve VBG cord-258129-c38q6xxs 127 17 intraperitoneal intraperitoneal JJ cord-258129-c38q6xxs 127 18 inoculation inoculation NN cord-258129-c38q6xxs 127 19 of of IN cord-258129-c38q6xxs 127 20 E. E. NNP cord-258129-c38q6xxs 127 21 coli coli NNS cord-258129-c38q6xxs 127 22 . . . cord-258129-c38q6xxs 128 1 They -PRON- PRP cord-258129-c38q6xxs 128 2 found find VBD cord-258129-c38q6xxs 128 3 that that IN cord-258129-c38q6xxs 128 4 the the DT cord-258129-c38q6xxs 128 5 intraperitoneal intraperitoneal JJ cord-258129-c38q6xxs 128 6 administration administration NN cord-258129-c38q6xxs 128 7 of of IN cord-258129-c38q6xxs 128 8 resolvin resolvin NNP cord-258129-c38q6xxs 128 9 D5 D5 NNP cord-258129-c38q6xxs 128 10 enhanced enhance VBN cord-258129-c38q6xxs 128 11 phagocytosis phagocytosis NN cord-258129-c38q6xxs 128 12 of of IN cord-258129-c38q6xxs 128 13 bacteria bacteria NNS cord-258129-c38q6xxs 128 14 in in IN cord-258129-c38q6xxs 128 15 comparison comparison NN cord-258129-c38q6xxs 128 16 to to IN cord-258129-c38q6xxs 128 17 mice mouse NNS cord-258129-c38q6xxs 128 18 inoculated inoculate VBN cord-258129-c38q6xxs 128 19 with with IN cord-258129-c38q6xxs 128 20 E. E. NNP cord-258129-c38q6xxs 128 21 coli coli NNS cord-258129-c38q6xxs 128 22 without without IN cord-258129-c38q6xxs 128 23 resolvin resolvin NNP cord-258129-c38q6xxs 128 24 . . . cord-258129-c38q6xxs 129 1 Resolvin Resolvin NNP cord-258129-c38q6xxs 129 2 D1 D1 NNP cord-258129-c38q6xxs 129 3 had have VBD cord-258129-c38q6xxs 129 4 a a DT cord-258129-c38q6xxs 129 5 similar similar JJ cord-258129-c38q6xxs 129 6 but but CC cord-258129-c38q6xxs 129 7 smaller small JJR cord-258129-c38q6xxs 129 8 effect effect NN cord-258129-c38q6xxs 129 9 . . . cord-258129-c38q6xxs 130 1 Administration Administration NNP cord-258129-c38q6xxs 130 2 of of IN cord-258129-c38q6xxs 130 3 resolvin resolvin NNP cord-258129-c38q6xxs 130 4 ( ( -LRB- cord-258129-c38q6xxs 130 5 D1 D1 NNP cord-258129-c38q6xxs 130 6 or or CC cord-258129-c38q6xxs 130 7 D5 D5 NNP cord-258129-c38q6xxs 130 8 ) ) -RRB- cord-258129-c38q6xxs 130 9 was be VBD cord-258129-c38q6xxs 130 10 also also RB cord-258129-c38q6xxs 130 11 associated associate VBN cord-258129-c38q6xxs 130 12 with with IN cord-258129-c38q6xxs 130 13 a a DT cord-258129-c38q6xxs 130 14 significantly significantly RB cord-258129-c38q6xxs 130 15 lower low JJR cord-258129-c38q6xxs 130 16 titre titre NN cord-258129-c38q6xxs 130 17 of of IN cord-258129-c38q6xxs 130 18 viable viable JJ cord-258129-c38q6xxs 130 19 bacteria bacteria NNS cord-258129-c38q6xxs 130 20 in in IN cord-258129-c38q6xxs 130 21 the the DT cord-258129-c38q6xxs 130 22 blood blood NN cord-258129-c38q6xxs 130 23 and and CC cord-258129-c38q6xxs 130 24 peritoneal peritoneal NN cord-258129-c38q6xxs 130 25 exudate exudate NN cord-258129-c38q6xxs 130 26 , , , cord-258129-c38q6xxs 130 27 as as RB cord-258129-c38q6xxs 130 28 well well RB cord-258129-c38q6xxs 130 29 as as IN cord-258129-c38q6xxs 130 30 a a DT cord-258129-c38q6xxs 130 31 lesser less JJR cord-258129-c38q6xxs 130 32 degree degree NN cord-258129-c38q6xxs 130 33 of of IN cord-258129-c38q6xxs 130 34 hypothermia hypothermia NN cord-258129-c38q6xxs 130 35 . . . cord-258129-c38q6xxs 131 1 Importantly importantly RB cord-258129-c38q6xxs 131 2 , , , cord-258129-c38q6xxs 131 3 resolvin resolvin NNP cord-258129-c38q6xxs 131 4 D1 D1 NNP cord-258129-c38q6xxs 131 5 increased increase VBD cord-258129-c38q6xxs 131 6 survival survival NN cord-258129-c38q6xxs 131 7 in in IN cord-258129-c38q6xxs 131 8 this this DT cord-258129-c38q6xxs 131 9 model model NN cord-258129-c38q6xxs 131 10 . . . cord-258129-c38q6xxs 132 1 As as IN cord-258129-c38q6xxs 132 2 for for IN cord-258129-c38q6xxs 132 3 the the DT cord-258129-c38q6xxs 132 4 model model NN cord-258129-c38q6xxs 132 5 of of IN cord-258129-c38q6xxs 132 6 microbial microbial JJ cord-258129-c38q6xxs 132 7 sepsis sepsis NN cord-258129-c38q6xxs 132 8 discussed discuss VBN cord-258129-c38q6xxs 132 9 previously previously RB cord-258129-c38q6xxs 132 10 , , , cord-258129-c38q6xxs 132 11 plasma plasma NN cord-258129-c38q6xxs 132 12 levels level NNS cord-258129-c38q6xxs 132 13 of of IN cord-258129-c38q6xxs 132 14 pro pro JJ cord-258129-c38q6xxs 132 15 - - JJ cord-258129-c38q6xxs 132 16 inflammatory inflammatory JJ cord-258129-c38q6xxs 132 17 cytokines cytokine NNS cord-258129-c38q6xxs 132 18 ( ( -LRB- cord-258129-c38q6xxs 132 19 including include VBG cord-258129-c38q6xxs 132 20 TNF TNF NNP cord-258129-c38q6xxs 132 21 - - HYPH cord-258129-c38q6xxs 132 22 a a NNP cord-258129-c38q6xxs 132 23 and and CC cord-258129-c38q6xxs 132 24 IL-1b IL-1b NNS cord-258129-c38q6xxs 132 25 ) ) -RRB- cord-258129-c38q6xxs 132 26 were be VBD cord-258129-c38q6xxs 132 27 reduced reduce VBN cord-258129-c38q6xxs 132 28 by by IN cord-258129-c38q6xxs 132 29 resolvin resolvin NNP cord-258129-c38q6xxs 132 30 administration administration NNP cord-258129-c38q6xxs 132 31 . . . cord-258129-c38q6xxs 133 1 Interestingly interestingly RB cord-258129-c38q6xxs 133 2 , , , cord-258129-c38q6xxs 133 3 it -PRON- PRP cord-258129-c38q6xxs 133 4 was be VBD cord-258129-c38q6xxs 133 5 found find VBN cord-258129-c38q6xxs 133 6 that that IN cord-258129-c38q6xxs 133 7 resolvin resolvin NNP cord-258129-c38q6xxs 133 8 D1 D1 NNP cord-258129-c38q6xxs 133 9 enhanced enhance VBD cord-258129-c38q6xxs 133 10 the the DT cord-258129-c38q6xxs 133 11 antimicrobial antimicrobial JJ cord-258129-c38q6xxs 133 12 effect effect NN cord-258129-c38q6xxs 133 13 of of IN cord-258129-c38q6xxs 133 14 ciprofloxacin ciprofloxacin NN cord-258129-c38q6xxs 133 15 in in IN cord-258129-c38q6xxs 133 16 resolving resolve VBG cord-258129-c38q6xxs 133 17 E. E. NNP cord-258129-c38q6xxs 133 18 coli coli NNS cord-258129-c38q6xxs 133 19 peritonitis peritonitis NN cord-258129-c38q6xxs 133 20 . . . cord-258129-c38q6xxs 134 1 When when WRB cord-258129-c38q6xxs 134 2 given give VBN cord-258129-c38q6xxs 134 3 in in IN cord-258129-c38q6xxs 134 4 combination combination NN cord-258129-c38q6xxs 134 5 , , , cord-258129-c38q6xxs 134 6 resolvin resolvin NNP cord-258129-c38q6xxs 134 7 and and CC cord-258129-c38q6xxs 134 8 ciprofloxacin ciprofloxacin NNP cord-258129-c38q6xxs 134 9 had have VBD cord-258129-c38q6xxs 134 10 an an DT cord-258129-c38q6xxs 134 11 additive additive NN cord-258129-c38q6xxs 134 12 effect effect NN cord-258129-c38q6xxs 134 13 on on IN cord-258129-c38q6xxs 134 14 reducing reduce VBG cord-258129-c38q6xxs 134 15 the the DT cord-258129-c38q6xxs 134 16 ' ' `` cord-258129-c38q6xxs 134 17 resolution resolution NN cord-258129-c38q6xxs 134 18 interval interval NN cord-258129-c38q6xxs 134 19 ' ' '' cord-258129-c38q6xxs 134 20 ( ( -LRB- cord-258129-c38q6xxs 134 21 time time NN cord-258129-c38q6xxs 134 22 from from IN cord-258129-c38q6xxs 134 23 maximum maximum JJ cord-258129-c38q6xxs 134 24 concentration concentration NN cord-258129-c38q6xxs 134 25 of of IN cord-258129-c38q6xxs 134 26 peritoneal peritoneal JJ cord-258129-c38q6xxs 134 27 leucocytes leucocyte NNS cord-258129-c38q6xxs 134 28 to to IN cord-258129-c38q6xxs 134 29 50 50 CD cord-258129-c38q6xxs 134 30 % % NN cord-258129-c38q6xxs 134 31 ) ) -RRB- cord-258129-c38q6xxs 134 32 , , , cord-258129-c38q6xxs 134 33 greater great JJR cord-258129-c38q6xxs 134 34 than than IN cord-258129-c38q6xxs 134 35 either either DT cord-258129-c38q6xxs 134 36 agent agent NN cord-258129-c38q6xxs 134 37 given give VBN cord-258129-c38q6xxs 134 38 alone alone RB cord-258129-c38q6xxs 134 39 . . . cord-258129-c38q6xxs 135 1 In in IN cord-258129-c38q6xxs 135 2 addition addition NN cord-258129-c38q6xxs 135 3 , , , cord-258129-c38q6xxs 135 4 the the DT cord-258129-c38q6xxs 135 5 combined combined JJ cord-258129-c38q6xxs 135 6 administration administration NN cord-258129-c38q6xxs 135 7 of of IN cord-258129-c38q6xxs 135 8 ciprofloxacin ciprofloxacin NNP cord-258129-c38q6xxs 135 9 and and CC cord-258129-c38q6xxs 135 10 resolvin resolvin NNP cord-258129-c38q6xxs 135 11 D1 D1 NNP cord-258129-c38q6xxs 135 12 resulted result VBD cord-258129-c38q6xxs 135 13 in in IN cord-258129-c38q6xxs 135 14 lower low JJR cord-258129-c38q6xxs 135 15 titres titre NNS cord-258129-c38q6xxs 135 16 of of IN cord-258129-c38q6xxs 135 17 viable viable JJ cord-258129-c38q6xxs 135 18 bacteria bacteria NNS cord-258129-c38q6xxs 135 19 in in IN cord-258129-c38q6xxs 135 20 blood blood NN cord-258129-c38q6xxs 135 21 and and CC cord-258129-c38q6xxs 135 22 peritoneal peritoneal NN cord-258129-c38q6xxs 135 23 exudate exudate NN cord-258129-c38q6xxs 135 24 , , , cord-258129-c38q6xxs 135 25 and and CC cord-258129-c38q6xxs 135 26 enhanced enhanced JJ cord-258129-c38q6xxs 135 27 macrophage macrophage NN cord-258129-c38q6xxs 135 28 phagocytic phagocytic JJ cord-258129-c38q6xxs 135 29 activity activity NN cord-258129-c38q6xxs 135 30 ( ( -LRB- cord-258129-c38q6xxs 135 31 not not RB cord-258129-c38q6xxs 135 32 seen see VBN cord-258129-c38q6xxs 135 33 with with IN cord-258129-c38q6xxs 135 34 either either DT cord-258129-c38q6xxs 135 35 agent agent NN cord-258129-c38q6xxs 135 36 alone alone RB cord-258129-c38q6xxs 135 37 ) ) -RRB- cord-258129-c38q6xxs 135 38 . . . cord-258129-c38q6xxs 136 1 The the DT cord-258129-c38q6xxs 136 2 effect effect NN cord-258129-c38q6xxs 136 3 of of IN cord-258129-c38q6xxs 136 4 reducing reduce VBG cord-258129-c38q6xxs 136 5 bacterial bacterial JJ cord-258129-c38q6xxs 136 6 titres titre NNS cord-258129-c38q6xxs 136 7 was be VBD cord-258129-c38q6xxs 136 8 still still RB cord-258129-c38q6xxs 136 9 seen see VBN cord-258129-c38q6xxs 136 10 even even RB cord-258129-c38q6xxs 136 11 when when WRB cord-258129-c38q6xxs 136 12 ciprofloxacin ciprofloxacin NN cord-258129-c38q6xxs 136 13 was be VBD cord-258129-c38q6xxs 136 14 administered administer VBN cord-258129-c38q6xxs 136 15 at at IN cord-258129-c38q6xxs 136 16 sub sub JJ cord-258129-c38q6xxs 136 17 - - JJ cord-258129-c38q6xxs 136 18 optimal optimal JJ cord-258129-c38q6xxs 136 19 concentrations concentration NNS cord-258129-c38q6xxs 136 20 with with IN cord-258129-c38q6xxs 136 21 a a DT cord-258129-c38q6xxs 136 22 cocktail cocktail NN cord-258129-c38q6xxs 136 23 of of IN cord-258129-c38q6xxs 136 24 resolvin resolvin NNP cord-258129-c38q6xxs 136 25 D1 D1 NNP cord-258129-c38q6xxs 136 26 , , , cord-258129-c38q6xxs 136 27 D5 D5 NNP cord-258129-c38q6xxs 136 28 and and CC cord-258129-c38q6xxs 136 29 protectin protectin NNP cord-258129-c38q6xxs 136 30 D1 D1 NNP cord-258129-c38q6xxs 136 31 . . . cord-258129-c38q6xxs 137 1 In in IN cord-258129-c38q6xxs 137 2 Staphylococcus Staphylococcus NNP cord-258129-c38q6xxs 137 3 aureus aureus NN cord-258129-c38q6xxs 137 4 skin skin NN cord-258129-c38q6xxs 137 5 infection infection NN cord-258129-c38q6xxs 137 6 , , , cord-258129-c38q6xxs 137 7 using use VBG cord-258129-c38q6xxs 137 8 mouse mouse NN cord-258129-c38q6xxs 137 9 dorsal dorsal JJ cord-258129-c38q6xxs 137 10 skin skin NN cord-258129-c38q6xxs 137 11 pouches pouch NNS cord-258129-c38q6xxs 137 12 , , , cord-258129-c38q6xxs 137 13 resolvins resolvins NNP cord-258129-c38q6xxs 137 14 D1 D1 NNP cord-258129-c38q6xxs 137 15 and and CC cord-258129-c38q6xxs 137 16 D5 D5 NNP cord-258129-c38q6xxs 137 17 plus plus CC cord-258129-c38q6xxs 137 18 protectin protectin NNP cord-258129-c38q6xxs 137 19 D1 D1 NNP cord-258129-c38q6xxs 137 20 , , , cord-258129-c38q6xxs 137 21 when when WRB cord-258129-c38q6xxs 137 22 administered administer VBN cord-258129-c38q6xxs 137 23 with with IN cord-258129-c38q6xxs 137 24 vancomycin vancomycin NN cord-258129-c38q6xxs 137 25 ( ( -LRB- cord-258129-c38q6xxs 137 26 at at IN cord-258129-c38q6xxs 137 27 a a DT cord-258129-c38q6xxs 137 28 sub sub JJ cord-258129-c38q6xxs 137 29 - - JJ cord-258129-c38q6xxs 137 30 optimal optimal JJ cord-258129-c38q6xxs 137 31 concentration concentration NN cord-258129-c38q6xxs 137 32 ) ) -RRB- cord-258129-c38q6xxs 137 33 into into IN cord-258129-c38q6xxs 137 34 the the DT cord-258129-c38q6xxs 137 35 pouch pouch NN cord-258129-c38q6xxs 137 36 , , , cord-258129-c38q6xxs 137 37 enhanced enhance VBD cord-258129-c38q6xxs 137 38 the the DT cord-258129-c38q6xxs 137 39 clearance clearance NN cord-258129-c38q6xxs 137 40 of of IN cord-258129-c38q6xxs 137 41 bacteria bacteria NNS cord-258129-c38q6xxs 137 42 , , , cord-258129-c38q6xxs 137 43 resulting result VBG cord-258129-c38q6xxs 137 44 in in IN cord-258129-c38q6xxs 137 45 lower low JJR cord-258129-c38q6xxs 137 46 viable viable JJ cord-258129-c38q6xxs 137 47 bacterial bacterial JJ cord-258129-c38q6xxs 137 48 titres titre NNS cord-258129-c38q6xxs 137 49 in in IN cord-258129-c38q6xxs 137 50 pouch pouch NN cord-258129-c38q6xxs 137 51 exudate exudate NN cord-258129-c38q6xxs 137 52 and and CC cord-258129-c38q6xxs 137 53 reduced reduced JJ cord-258129-c38q6xxs 137 54 neutrophil neutrophil NN cord-258129-c38q6xxs 137 55 infiltration infiltration NN cord-258129-c38q6xxs 137 56 . . . cord-258129-c38q6xxs 138 1 This this DT cord-258129-c38q6xxs 138 2 effect effect NN cord-258129-c38q6xxs 138 3 was be VBD cord-258129-c38q6xxs 138 4 also also RB cord-258129-c38q6xxs 138 5 seen see VBN cord-258129-c38q6xxs 138 6 when when WRB cord-258129-c38q6xxs 138 7 either either CC cord-258129-c38q6xxs 138 8 resolvin resolvin NN cord-258129-c38q6xxs 138 9 or or CC cord-258129-c38q6xxs 138 10 vancomycin vancomycin NNP cord-258129-c38q6xxs 138 11 was be VBD cord-258129-c38q6xxs 138 12 administered administer VBN cord-258129-c38q6xxs 138 13 alone alone RB cord-258129-c38q6xxs 138 14 , , , cord-258129-c38q6xxs 138 15 but but CC cord-258129-c38q6xxs 138 16 again again RB cord-258129-c38q6xxs 138 17 , , , cord-258129-c38q6xxs 138 18 an an DT cord-258129-c38q6xxs 138 19 enhanced enhanced JJ cord-258129-c38q6xxs 138 20 effect effect NN cord-258129-c38q6xxs 138 21 was be VBD cord-258129-c38q6xxs 138 22 seen see VBN cord-258129-c38q6xxs 138 23 when when WRB cord-258129-c38q6xxs 138 24 both both DT cord-258129-c38q6xxs 138 25 were be VBD cord-258129-c38q6xxs 138 26 given give VBN cord-258129-c38q6xxs 138 27 together together RB cord-258129-c38q6xxs 138 28 . . . cord-258129-c38q6xxs 139 1 Infection infection NN cord-258129-c38q6xxs 139 2 secondary secondary JJ cord-258129-c38q6xxs 139 3 to to IN cord-258129-c38q6xxs 139 4 burns burn NNS cord-258129-c38q6xxs 139 5 is be VBZ cord-258129-c38q6xxs 139 6 an an DT cord-258129-c38q6xxs 139 7 important important JJ cord-258129-c38q6xxs 139 8 clinical clinical JJ cord-258129-c38q6xxs 139 9 problem problem NN cord-258129-c38q6xxs 139 10 and and CC cord-258129-c38q6xxs 139 11 burns burn NNS cord-258129-c38q6xxs 139 12 - - HYPH cord-258129-c38q6xxs 139 13 related relate VBN cord-258129-c38q6xxs 139 14 sepsis sepsis NN cord-258129-c38q6xxs 139 15 is be VBZ cord-258129-c38q6xxs 139 16 responsible responsible JJ cord-258129-c38q6xxs 139 17 for for IN cord-258129-c38q6xxs 139 18 significant significant JJ cord-258129-c38q6xxs 139 19 mortality mortality NN cord-258129-c38q6xxs 139 20 in in IN cord-258129-c38q6xxs 139 21 burns burn NNS cord-258129-c38q6xxs 139 22 patients patient NNS cord-258129-c38q6xxs 139 23 . . . cord-258129-c38q6xxs 140 1 Using use VBG cord-258129-c38q6xxs 140 2 a a DT cord-258129-c38q6xxs 140 3 rat rat NN cord-258129-c38q6xxs 140 4 model model NN cord-258129-c38q6xxs 140 5 of of IN cord-258129-c38q6xxs 140 6 burn burn NN cord-258129-c38q6xxs 140 7 injury injury NN cord-258129-c38q6xxs 140 8 , , , cord-258129-c38q6xxs 140 9 Kurihara Kurihara NNP cord-258129-c38q6xxs 140 10 et et NNP cord-258129-c38q6xxs 140 11 al al NNP cord-258129-c38q6xxs 140 12 . . . cord-258129-c38q6xxs 141 1 31 31 CD cord-258129-c38q6xxs 141 2 demonstrated demonstrate VBD cord-258129-c38q6xxs 141 3 that that IN cord-258129-c38q6xxs 141 4 neutrophils neutrophil NNS cord-258129-c38q6xxs 141 5 isolated isolate VBN cord-258129-c38q6xxs 141 6 from from IN cord-258129-c38q6xxs 141 7 burned burn VBN cord-258129-c38q6xxs 141 8 rats rat NNS cord-258129-c38q6xxs 141 9 were be VBD cord-258129-c38q6xxs 141 10 impaired impair VBN cord-258129-c38q6xxs 141 11 in in IN cord-258129-c38q6xxs 141 12 their -PRON- PRP$ cord-258129-c38q6xxs 141 13 ability ability NN cord-258129-c38q6xxs 141 14 to to TO cord-258129-c38q6xxs 141 15 migrate migrate VB cord-258129-c38q6xxs 141 16 towards towards IN cord-258129-c38q6xxs 141 17 a a DT cord-258129-c38q6xxs 141 18 chemoattractant chemoattractant NN cord-258129-c38q6xxs 141 19 . . . cord-258129-c38q6xxs 142 1 This this DT cord-258129-c38q6xxs 142 2 defect defect NN cord-258129-c38q6xxs 142 3 in in IN cord-258129-c38q6xxs 142 4 neutrophil neutrophil NN cord-258129-c38q6xxs 142 5 chemotaxis chemotaxis NN cord-258129-c38q6xxs 142 6 could could MD cord-258129-c38q6xxs 142 7 result result VB cord-258129-c38q6xxs 142 8 in in IN cord-258129-c38q6xxs 142 9 an an DT cord-258129-c38q6xxs 142 10 inability inability NN cord-258129-c38q6xxs 142 11 of of IN cord-258129-c38q6xxs 142 12 neutrophils neutrophil NNS cord-258129-c38q6xxs 142 13 in in IN cord-258129-c38q6xxs 142 14 burns burn NNS cord-258129-c38q6xxs 142 15 patients patient NNS cord-258129-c38q6xxs 142 16 to to TO cord-258129-c38q6xxs 142 17 successfully successfully RB cord-258129-c38q6xxs 142 18 reach reach VB cord-258129-c38q6xxs 142 19 and and CC cord-258129-c38q6xxs 142 20 kill kill VB cord-258129-c38q6xxs 142 21 infectious infectious JJ cord-258129-c38q6xxs 142 22 agents agent NNS cord-258129-c38q6xxs 142 23 . . . cord-258129-c38q6xxs 143 1 As as IN cord-258129-c38q6xxs 143 2 a a DT cord-258129-c38q6xxs 143 3 consequence consequence NN cord-258129-c38q6xxs 143 4 , , , cord-258129-c38q6xxs 143 5 these these DT cord-258129-c38q6xxs 143 6 ' ' `` cord-258129-c38q6xxs 143 7 lost lost JJ cord-258129-c38q6xxs 143 8 ' ' '' cord-258129-c38q6xxs 143 9 neutrophils neutrophil NNS cord-258129-c38q6xxs 143 10 activated activate VBN cord-258129-c38q6xxs 143 11 by by IN cord-258129-c38q6xxs 143 12 the the DT cord-258129-c38q6xxs 143 13 burn burn NN cord-258129-c38q6xxs 143 14 injury injury NN cord-258129-c38q6xxs 143 15 may may MD cord-258129-c38q6xxs 143 16 accumulate accumulate VB cord-258129-c38q6xxs 143 17 and and CC cord-258129-c38q6xxs 143 18 initiate initiate VB cord-258129-c38q6xxs 143 19 tissue tissue NN cord-258129-c38q6xxs 143 20 damage damage NN cord-258129-c38q6xxs 143 21 inappropriately inappropriately RB cord-258129-c38q6xxs 143 22 in in IN cord-258129-c38q6xxs 143 23 healthy healthy JJ cord-258129-c38q6xxs 143 24 tissues tissue NNS cord-258129-c38q6xxs 143 25 . . . cord-258129-c38q6xxs 144 1 By by IN cord-258129-c38q6xxs 144 2 administering administer VBG cord-258129-c38q6xxs 144 3 resolvin resolvin NNP cord-258129-c38q6xxs 144 4 D2 D2 NNP cord-258129-c38q6xxs 144 5 to to IN cord-258129-c38q6xxs 144 6 the the DT cord-258129-c38q6xxs 144 7 burned burn VBN cord-258129-c38q6xxs 144 8 rats rat NNS cord-258129-c38q6xxs 144 9 , , , cord-258129-c38q6xxs 144 10 Kurihara Kurihara NNP cord-258129-c38q6xxs 144 11 et et NNP cord-258129-c38q6xxs 144 12 al al NNP cord-258129-c38q6xxs 144 13 . . NNP cord-258129-c38q6xxs 144 14 found find VBD cord-258129-c38q6xxs 144 15 that that IN cord-258129-c38q6xxs 144 16 neutrophil neutrophil NN cord-258129-c38q6xxs 144 17 chemotaxis chemotaxis NN cord-258129-c38q6xxs 144 18 was be VBD cord-258129-c38q6xxs 144 19 restored restore VBN cord-258129-c38q6xxs 144 20 to to IN cord-258129-c38q6xxs 144 21 almost almost RB cord-258129-c38q6xxs 144 22 normal normal JJ cord-258129-c38q6xxs 144 23 . . . cord-258129-c38q6xxs 145 1 When when WRB cord-258129-c38q6xxs 145 2 burned burn VBN cord-258129-c38q6xxs 145 3 rats rat NNS cord-258129-c38q6xxs 145 4 received receive VBD cord-258129-c38q6xxs 145 5 intravenous intravenous JJ cord-258129-c38q6xxs 145 6 lipopolysaccharide lipopolysaccharide NN cord-258129-c38q6xxs 145 7 9 9 CD cord-258129-c38q6xxs 145 8 days day NNS cord-258129-c38q6xxs 145 9 after after IN cord-258129-c38q6xxs 145 10 their -PRON- PRP$ cord-258129-c38q6xxs 145 11 burn burn NN cord-258129-c38q6xxs 145 12 injury injury NN cord-258129-c38q6xxs 145 13 , , , cord-258129-c38q6xxs 145 14 pretreatment pretreatment NN cord-258129-c38q6xxs 145 15 with with IN cord-258129-c38q6xxs 145 16 intravenous intravenous JJ cord-258129-c38q6xxs 145 17 resolvin resolvin NNP cord-258129-c38q6xxs 145 18 D2 D2 NNP cord-258129-c38q6xxs 145 19 improved improve VBD cord-258129-c38q6xxs 145 20 survival survival NN cord-258129-c38q6xxs 145 21 significantly significantly RB cord-258129-c38q6xxs 145 22 . . . cord-258129-c38q6xxs 146 1 Similarly similarly RB cord-258129-c38q6xxs 146 2 , , , cord-258129-c38q6xxs 146 3 resolvin resolvin NNP cord-258129-c38q6xxs 146 4 D2 D2 NNP cord-258129-c38q6xxs 146 5 pre pre JJ cord-258129-c38q6xxs 146 6 - - JJ cord-258129-c38q6xxs 146 7 treatment treatment JJ cord-258129-c38q6xxs 146 8 increased increase VBN cord-258129-c38q6xxs 146 9 survival survival NN cord-258129-c38q6xxs 146 10 following follow VBG cord-258129-c38q6xxs 146 11 caecal caecal JJ cord-258129-c38q6xxs 146 12 ligation ligation NN cord-258129-c38q6xxs 146 13 after after IN cord-258129-c38q6xxs 146 14 burns burn NNS cord-258129-c38q6xxs 146 15 injury injury NN cord-258129-c38q6xxs 146 16 . . . cord-258129-c38q6xxs 147 1 A a DT cord-258129-c38q6xxs 147 2 shorter short JJR cord-258129-c38q6xxs 147 3 duration duration NN cord-258129-c38q6xxs 147 4 of of IN cord-258129-c38q6xxs 147 5 resolvin resolvin NNP cord-258129-c38q6xxs 147 6 treatment treatment NN cord-258129-c38q6xxs 147 7 that that WDT cord-258129-c38q6xxs 147 8 was be VBD cord-258129-c38q6xxs 147 9 insufficient insufficient JJ cord-258129-c38q6xxs 147 10 to to TO cord-258129-c38q6xxs 147 11 normalize normalize VB cord-258129-c38q6xxs 147 12 neutrophil neutrophil NN cord-258129-c38q6xxs 147 13 chemotaxis chemotaxis NN cord-258129-c38q6xxs 147 14 did do VBD cord-258129-c38q6xxs 147 15 not not RB cord-258129-c38q6xxs 147 16 significantly significantly RB cord-258129-c38q6xxs 147 17 improve improve VB cord-258129-c38q6xxs 147 18 survival survival NN cord-258129-c38q6xxs 147 19 in in IN cord-258129-c38q6xxs 147 20 these these DT cord-258129-c38q6xxs 147 21 two two CD cord-258129-c38q6xxs 147 22 models model NNS cord-258129-c38q6xxs 147 23 of of IN cord-258129-c38q6xxs 147 24 burns burn NNS cord-258129-c38q6xxs 147 25 - - HYPH cord-258129-c38q6xxs 147 26 related relate VBN cord-258129-c38q6xxs 147 27 sepsis sepsis NN cord-258129-c38q6xxs 147 28 . . . cord-258129-c38q6xxs 148 1 Therefore therefore RB cord-258129-c38q6xxs 148 2 , , , cord-258129-c38q6xxs 148 3 this this DT cord-258129-c38q6xxs 148 4 study study NN cord-258129-c38q6xxs 148 5 suggests suggest VBZ cord-258129-c38q6xxs 148 6 that that IN cord-258129-c38q6xxs 148 7 administering administer VBG cord-258129-c38q6xxs 148 8 resolvin resolvin NNP cord-258129-c38q6xxs 148 9 D2 D2 NNP cord-258129-c38q6xxs 148 10 could could MD cord-258129-c38q6xxs 148 11 improve improve VB cord-258129-c38q6xxs 148 12 outcomes outcome NNS cord-258129-c38q6xxs 148 13 in in IN cord-258129-c38q6xxs 148 14 burns burn NNS cord-258129-c38q6xxs 148 15 - - HYPH cord-258129-c38q6xxs 148 16 related relate VBN cord-258129-c38q6xxs 148 17 sepsis sepsis NN cord-258129-c38q6xxs 148 18 by by IN cord-258129-c38q6xxs 148 19 modulating modulate VBG cord-258129-c38q6xxs 148 20 neutrophil neutrophil NN cord-258129-c38q6xxs 148 21 chemotaxis chemotaxis NN cord-258129-c38q6xxs 148 22 . . . cord-258129-c38q6xxs 149 1 The the DT cord-258129-c38q6xxs 149 2 role role NN cord-258129-c38q6xxs 149 3 of of IN cord-258129-c38q6xxs 149 4 resolvin resolvin NNP cord-258129-c38q6xxs 149 5 E1 E1 NNP cord-258129-c38q6xxs 149 6 in in IN cord-258129-c38q6xxs 149 7 bacterial bacterial JJ cord-258129-c38q6xxs 149 8 pneumonia pneumonia NN cord-258129-c38q6xxs 149 9 and and CC cord-258129-c38q6xxs 149 10 acute acute JJ cord-258129-c38q6xxs 149 11 lung lung NN cord-258129-c38q6xxs 149 12 injury injury NN cord-258129-c38q6xxs 149 13 was be VBD cord-258129-c38q6xxs 149 14 investigated investigate VBN cord-258129-c38q6xxs 149 15 using use VBG cord-258129-c38q6xxs 149 16 a a DT cord-258129-c38q6xxs 149 17 mouse mouse NN cord-258129-c38q6xxs 149 18 model model NN cord-258129-c38q6xxs 149 19 of of IN cord-258129-c38q6xxs 149 20 aspiration aspiration NN cord-258129-c38q6xxs 149 21 pneumonia pneumonia NN cord-258129-c38q6xxs 149 22 . . . cord-258129-c38q6xxs 150 1 32 32 CD cord-258129-c38q6xxs 150 2 Mice mouse NNS cord-258129-c38q6xxs 150 3 were be VBD cord-258129-c38q6xxs 150 4 administered administer VBN cord-258129-c38q6xxs 150 5 hydrochloric hydrochloric JJ cord-258129-c38q6xxs 150 6 acid acid NN cord-258129-c38q6xxs 150 7 followed follow VBN cord-258129-c38q6xxs 150 8 by by IN cord-258129-c38q6xxs 150 9 E. E. NNP cord-258129-c38q6xxs 150 10 coli coli NNS cord-258129-c38q6xxs 150 11 into into IN cord-258129-c38q6xxs 150 12 a a DT cord-258129-c38q6xxs 150 13 lung lung NN cord-258129-c38q6xxs 150 14 . . . cord-258129-c38q6xxs 151 1 Resolvin Resolvin NNP cord-258129-c38q6xxs 151 2 E1 E1 NNP cord-258129-c38q6xxs 151 3 , , , cord-258129-c38q6xxs 151 4 when when WRB cord-258129-c38q6xxs 151 5 given give VBN cord-258129-c38q6xxs 151 6 intravenously intravenously RB cord-258129-c38q6xxs 151 7 before before IN cord-258129-c38q6xxs 151 8 this this DT cord-258129-c38q6xxs 151 9 insult insult NN cord-258129-c38q6xxs 151 10 , , , cord-258129-c38q6xxs 151 11 reduced reduce VBN cord-258129-c38q6xxs 151 12 pulmonary pulmonary JJ cord-258129-c38q6xxs 151 13 neutrophil neutrophil NN cord-258129-c38q6xxs 151 14 infiltration infiltration NN cord-258129-c38q6xxs 151 15 , , , cord-258129-c38q6xxs 151 16 enhanced enhance VBN cord-258129-c38q6xxs 151 17 bacterial bacterial JJ cord-258129-c38q6xxs 151 18 clearance clearance NN cord-258129-c38q6xxs 151 19 and and CC cord-258129-c38q6xxs 151 20 decreased decrease VBD cord-258129-c38q6xxs 151 21 levels level NNS cord-258129-c38q6xxs 151 22 of of IN cord-258129-c38q6xxs 151 23 pro pro JJ cord-258129-c38q6xxs 151 24 - - JJ cord-258129-c38q6xxs 151 25 inflammatory inflammatory JJ cord-258129-c38q6xxs 151 26 cytokines cytokine NNS cord-258129-c38q6xxs 151 27 ( ( -LRB- cord-258129-c38q6xxs 151 28 including include VBG cord-258129-c38q6xxs 151 29 IL-1b IL-1b NNP cord-258129-c38q6xxs 151 30 and and CC cord-258129-c38q6xxs 151 31 IL-6 IL-6 NNP cord-258129-c38q6xxs 151 32 ) ) -RRB- cord-258129-c38q6xxs 151 33 present present JJ cord-258129-c38q6xxs 151 34 in in IN cord-258129-c38q6xxs 151 35 lung lung NN cord-258129-c38q6xxs 151 36 tissue tissue NN cord-258129-c38q6xxs 151 37 homogenates homogenate NNS cord-258129-c38q6xxs 151 38 . . . cord-258129-c38q6xxs 152 1 Importantly importantly RB cord-258129-c38q6xxs 152 2 , , , cord-258129-c38q6xxs 152 3 mice mouse NNS cord-258129-c38q6xxs 152 4 administered administer VBD cord-258129-c38q6xxs 152 5 resolvin resolvin NNP cord-258129-c38q6xxs 152 6 E1 E1 NNP cord-258129-c38q6xxs 153 1 enjoyed enjoy VBN cord-258129-c38q6xxs 153 2 increased increase VBN cord-258129-c38q6xxs 153 3 survival survival NN cord-258129-c38q6xxs 153 4 ( ( -LRB- cord-258129-c38q6xxs 153 5 100 100 CD cord-258129-c38q6xxs 153 6 % % NN cord-258129-c38q6xxs 153 7 at at IN cord-258129-c38q6xxs 153 8 3 3 CD cord-258129-c38q6xxs 153 9 days day NNS cord-258129-c38q6xxs 153 10 , , , cord-258129-c38q6xxs 153 11 in in IN cord-258129-c38q6xxs 153 12 comparison comparison NN cord-258129-c38q6xxs 153 13 to to IN cord-258129-c38q6xxs 153 14 50 50 CD cord-258129-c38q6xxs 153 15 % % NN cord-258129-c38q6xxs 153 16 when when WRB cord-258129-c38q6xxs 153 17 only only RB cord-258129-c38q6xxs 153 18 0Á9 0á9 CD cord-258129-c38q6xxs 153 19 % % NN cord-258129-c38q6xxs 153 20 saline saline NN cord-258129-c38q6xxs 153 21 was be VBD cord-258129-c38q6xxs 153 22 administered administer VBN cord-258129-c38q6xxs 153 23 ) ) -RRB- cord-258129-c38q6xxs 153 24 . . . cord-258129-c38q6xxs 154 1 Neutrophil Neutrophil NNP cord-258129-c38q6xxs 154 2 apoptosis apoptosis NN cord-258129-c38q6xxs 154 3 is be VBZ cord-258129-c38q6xxs 154 4 known know VBN cord-258129-c38q6xxs 154 5 to to TO cord-258129-c38q6xxs 154 6 be be VB cord-258129-c38q6xxs 154 7 a a DT cord-258129-c38q6xxs 154 8 critical critical JJ cord-258129-c38q6xxs 154 9 event event NN cord-258129-c38q6xxs 154 10 in in IN cord-258129-c38q6xxs 154 11 the the DT cord-258129-c38q6xxs 154 12 resolution resolution NN cord-258129-c38q6xxs 154 13 of of IN cord-258129-c38q6xxs 154 14 pulmonary pulmonary JJ cord-258129-c38q6xxs 154 15 inflammation inflammation NN cord-258129-c38q6xxs 154 16 , , , cord-258129-c38q6xxs 154 17 and and CC cord-258129-c38q6xxs 154 18 suppression suppression NN cord-258129-c38q6xxs 154 19 of of IN cord-258129-c38q6xxs 154 20 this this DT cord-258129-c38q6xxs 154 21 process process NN cord-258129-c38q6xxs 154 22 is be VBZ cord-258129-c38q6xxs 154 23 thought think VBN cord-258129-c38q6xxs 154 24 to to TO cord-258129-c38q6xxs 154 25 contribute contribute VB cord-258129-c38q6xxs 154 26 to to IN cord-258129-c38q6xxs 154 27 the the DT cord-258129-c38q6xxs 154 28 pathology pathology NN cord-258129-c38q6xxs 154 29 seen see VBN cord-258129-c38q6xxs 154 30 in in IN cord-258129-c38q6xxs 154 31 acute acute JJ cord-258129-c38q6xxs 154 32 respiratory respiratory JJ cord-258129-c38q6xxs 154 33 distress distress NN cord-258129-c38q6xxs 154 34 syndrome syndrome NN cord-258129-c38q6xxs 154 35 and and CC cord-258129-c38q6xxs 154 36 sepsis sepsis NN cord-258129-c38q6xxs 154 37 . . . cord-258129-c38q6xxs 155 1 In in IN cord-258129-c38q6xxs 155 2 a a DT cord-258129-c38q6xxs 155 3 case case NN cord-258129-c38q6xxs 155 4 - - HYPH cord-258129-c38q6xxs 155 5 control control NN cord-258129-c38q6xxs 155 6 cohort cohort JJ cord-258129-c38q6xxs 155 7 study study NN cord-258129-c38q6xxs 155 8 of of IN cord-258129-c38q6xxs 155 9 121 121 CD cord-258129-c38q6xxs 155 10 intensive intensive JJ cord-258129-c38q6xxs 155 11 therapy therapy NN cord-258129-c38q6xxs 155 12 unit unit NN cord-258129-c38q6xxs 155 13 patients patient NNS cord-258129-c38q6xxs 155 14 with with IN cord-258129-c38q6xxs 155 15 or or CC cord-258129-c38q6xxs 155 16 without without IN cord-258129-c38q6xxs 155 17 sepsis sepsis NN cord-258129-c38q6xxs 155 18 , , , cord-258129-c38q6xxs 155 19 the the DT cord-258129-c38q6xxs 155 20 level level NN cord-258129-c38q6xxs 155 21 of of IN cord-258129-c38q6xxs 155 22 neutrophil neutrophil NN cord-258129-c38q6xxs 155 23 apoptosis apoptosis NN cord-258129-c38q6xxs 155 24 in in IN cord-258129-c38q6xxs 155 25 peripheral peripheral JJ cord-258129-c38q6xxs 155 26 venous venous JJ cord-258129-c38q6xxs 155 27 blood blood NN cord-258129-c38q6xxs 155 28 was be VBD cord-258129-c38q6xxs 155 29 found find VBN cord-258129-c38q6xxs 155 30 to to TO cord-258129-c38q6xxs 155 31 inversely inversely RB cord-258129-c38q6xxs 155 32 correlate correlate VB cord-258129-c38q6xxs 155 33 with with IN cord-258129-c38q6xxs 155 34 the the DT cord-258129-c38q6xxs 155 35 severity severity NN cord-258129-c38q6xxs 155 36 of of IN cord-258129-c38q6xxs 155 37 sepsis sepsis NN cord-258129-c38q6xxs 155 38 . . . cord-258129-c38q6xxs 156 1 33 33 CD cord-258129-c38q6xxs 157 1 The the DT cord-258129-c38q6xxs 157 2 role role NN cord-258129-c38q6xxs 157 3 of of IN cord-258129-c38q6xxs 157 4 resolvin resolvin NNP cord-258129-c38q6xxs 157 5 E1 E1 NNP cord-258129-c38q6xxs 157 6 in in IN cord-258129-c38q6xxs 157 7 this this DT cord-258129-c38q6xxs 157 8 process process NN cord-258129-c38q6xxs 157 9 has have VBZ cord-258129-c38q6xxs 157 10 been be VBN cord-258129-c38q6xxs 157 11 investigated investigate VBN cord-258129-c38q6xxs 157 12 in in IN cord-258129-c38q6xxs 157 13 mouse mouse NN cord-258129-c38q6xxs 157 14 models model NNS cord-258129-c38q6xxs 157 15 of of IN cord-258129-c38q6xxs 157 16 acute acute JJ cord-258129-c38q6xxs 157 17 lung lung NN cord-258129-c38q6xxs 157 18 injury injury NN cord-258129-c38q6xxs 157 19 , , , cord-258129-c38q6xxs 157 20 including include VBG cord-258129-c38q6xxs 157 21 an an DT cord-258129-c38q6xxs 157 22 E. E. NNP cord-258129-c38q6xxs 157 23 coli coli NNS cord-258129-c38q6xxs 157 24 pneumonia pneumonia NN cord-258129-c38q6xxs 157 25 model model NN cord-258129-c38q6xxs 157 26 and and CC cord-258129-c38q6xxs 157 27 an an DT cord-258129-c38q6xxs 157 28 E. E. NNP cord-258129-c38q6xxs 157 29 coli coli VBZ cord-258129-c38q6xxs 157 30 peritonitis peritonitis NN cord-258129-c38q6xxs 157 31 - - HYPH cord-258129-c38q6xxs 157 32 associated associate VBN cord-258129-c38q6xxs 157 33 acute acute JJ cord-258129-c38q6xxs 157 34 lung lung NN cord-258129-c38q6xxs 157 35 injury injury NN cord-258129-c38q6xxs 157 36 model model NN cord-258129-c38q6xxs 157 37 . . . cord-258129-c38q6xxs 158 1 34 34 CD cord-258129-c38q6xxs 158 2 Six six CD cord-258129-c38q6xxs 158 3 hours hour NNS cord-258129-c38q6xxs 158 4 after after IN cord-258129-c38q6xxs 158 5 intra intra JJ cord-258129-c38q6xxs 158 6 - - JJ cord-258129-c38q6xxs 158 7 tracheal tracheal JJ cord-258129-c38q6xxs 158 8 instillation instillation NN cord-258129-c38q6xxs 158 9 of of IN cord-258129-c38q6xxs 158 10 E. E. NNP cord-258129-c38q6xxs 158 11 coli coli NNS cord-258129-c38q6xxs 158 12 ( ( -LRB- cord-258129-c38q6xxs 158 13 pneumonia pneumonia NN cord-258129-c38q6xxs 158 14 model model NN cord-258129-c38q6xxs 158 15 ) ) -RRB- cord-258129-c38q6xxs 158 16 , , , cord-258129-c38q6xxs 158 17 intraperitoneal intraperitoneal JJ cord-258129-c38q6xxs 158 18 administration administration NN cord-258129-c38q6xxs 158 19 of of IN cord-258129-c38q6xxs 158 20 resolvin resolvin NNP cord-258129-c38q6xxs 158 21 E1 E1 NNP cord-258129-c38q6xxs 158 22 enhanced enhance VBD cord-258129-c38q6xxs 158 23 the the DT cord-258129-c38q6xxs 158 24 resolution resolution NN cord-258129-c38q6xxs 158 25 of of IN cord-258129-c38q6xxs 158 26 E. E. NNP cord-258129-c38q6xxs 158 27 coli coli NNS cord-258129-c38q6xxs 158 28 - - HYPH cord-258129-c38q6xxs 158 29 evoked evoke VBN cord-258129-c38q6xxs 158 30 pneumonia pneumonia NN cord-258129-c38q6xxs 158 31 in in IN cord-258129-c38q6xxs 158 32 this this DT cord-258129-c38q6xxs 158 33 mouse mouse NN cord-258129-c38q6xxs 158 34 model model NN cord-258129-c38q6xxs 158 35 . . . cord-258129-c38q6xxs 159 1 In in IN cord-258129-c38q6xxs 159 2 contrast contrast NN cord-258129-c38q6xxs 159 3 to to IN cord-258129-c38q6xxs 159 4 the the DT cord-258129-c38q6xxs 159 5 control control NN cord-258129-c38q6xxs 159 6 group group NN cord-258129-c38q6xxs 159 7 , , , cord-258129-c38q6xxs 159 8 mice mouse NNS cord-258129-c38q6xxs 159 9 administered administer VBD cord-258129-c38q6xxs 159 10 resolvin resolvin NNP cord-258129-c38q6xxs 159 11 had have VBD cord-258129-c38q6xxs 159 12 lower low JJR cord-258129-c38q6xxs 159 13 bronchoalveolar bronchoalveolar JJ cord-258129-c38q6xxs 159 14 lavage lavage NN cord-258129-c38q6xxs 159 15 neutrophil neutrophil NN cord-258129-c38q6xxs 159 16 counts count NNS cord-258129-c38q6xxs 159 17 , , , cord-258129-c38q6xxs 159 18 higher high JJR cord-258129-c38q6xxs 159 19 monocyte monocyte NNP cord-258129-c38q6xxs 159 20 / / SYM cord-258129-c38q6xxs 159 21 macrophage macrophage NN cord-258129-c38q6xxs 159 22 counts count NNS cord-258129-c38q6xxs 159 23 , , , cord-258129-c38q6xxs 159 24 increased increase VBN cord-258129-c38q6xxs 159 25 neutrophil neutrophil NN cord-258129-c38q6xxs 159 26 apoptosis apoptosis NN cord-258129-c38q6xxs 159 27 , , , cord-258129-c38q6xxs 159 28 reduced reduce VBN cord-258129-c38q6xxs 159 29 bronchoalveolar bronchoalveolar NNP cord-258129-c38q6xxs 159 30 lavage lavage NN cord-258129-c38q6xxs 159 31 IL-6 IL-6 NNP cord-258129-c38q6xxs 159 32 levels level NNS cord-258129-c38q6xxs 159 33 and and CC cord-258129-c38q6xxs 159 34 less less RBR cord-258129-c38q6xxs 159 35 severe severe JJ cord-258129-c38q6xxs 159 36 pulmonary pulmonary JJ cord-258129-c38q6xxs 159 37 inflammation inflammation NN cord-258129-c38q6xxs 159 38 when when WRB cord-258129-c38q6xxs 159 39 assessed assess VBN cord-258129-c38q6xxs 159 40 histologically histologically RB cord-258129-c38q6xxs 159 41 . . . cord-258129-c38q6xxs 160 1 When when WRB cord-258129-c38q6xxs 160 2 a a DT cord-258129-c38q6xxs 160 3 pan pan JJ cord-258129-c38q6xxs 160 4 - - JJ cord-258129-c38q6xxs 160 5 caspase caspase JJ cord-258129-c38q6xxs 160 6 inhibitor inhibitor NN cord-258129-c38q6xxs 160 7 was be VBD cord-258129-c38q6xxs 160 8 also also RB cord-258129-c38q6xxs 160 9 added add VBN cord-258129-c38q6xxs 160 10 intraperitoneally intraperitoneally RB cord-258129-c38q6xxs 160 11 , , , cord-258129-c38q6xxs 160 12 these these DT cord-258129-c38q6xxs 160 13 pro pro JJ cord-258129-c38q6xxs 160 14 - - JJ cord-258129-c38q6xxs 160 15 resolution resolution JJ cord-258129-c38q6xxs 160 16 effects effect NNS cord-258129-c38q6xxs 160 17 of of IN cord-258129-c38q6xxs 160 18 resolvin resolvin NNP cord-258129-c38q6xxs 160 19 were be VBD cord-258129-c38q6xxs 160 20 abrogated abrogate VBN cord-258129-c38q6xxs 160 21 , , , cord-258129-c38q6xxs 160 22 suggesting suggest VBG cord-258129-c38q6xxs 160 23 that that IN cord-258129-c38q6xxs 160 24 neutrophil neutrophil NN cord-258129-c38q6xxs 160 25 apoptosis apoptosis NN cord-258129-c38q6xxs 160 26 plays play VBZ cord-258129-c38q6xxs 160 27 a a DT cord-258129-c38q6xxs 160 28 critical critical JJ cord-258129-c38q6xxs 160 29 role role NN cord-258129-c38q6xxs 160 30 here here RB cord-258129-c38q6xxs 160 31 . . . cord-258129-c38q6xxs 161 1 In in IN cord-258129-c38q6xxs 161 2 the the DT cord-258129-c38q6xxs 161 3 E. E. NNP cord-258129-c38q6xxs 161 4 coli coli VBZ cord-258129-c38q6xxs 161 5 peritonitis peritonitis NN cord-258129-c38q6xxs 161 6 - - HYPH cord-258129-c38q6xxs 161 7 associated associate VBN cord-258129-c38q6xxs 161 8 acute acute JJ cord-258129-c38q6xxs 161 9 lung lung NN cord-258129-c38q6xxs 161 10 injury injury NN cord-258129-c38q6xxs 161 11 model model NN cord-258129-c38q6xxs 161 12 , , , cord-258129-c38q6xxs 161 13 intraperitoneal intraperitoneal JJ cord-258129-c38q6xxs 161 14 administration administration NN cord-258129-c38q6xxs 161 15 of of IN cord-258129-c38q6xxs 161 16 resolvin resolvin NNP cord-258129-c38q6xxs 161 17 E1 E1 NNP cord-258129-c38q6xxs 161 18 also also RB cord-258129-c38q6xxs 161 19 reduced reduce VBD cord-258129-c38q6xxs 161 20 bronchoalveolar bronchoalveolar JJ cord-258129-c38q6xxs 161 21 lavage lavage NN cord-258129-c38q6xxs 161 22 neutrophil neutrophil NN cord-258129-c38q6xxs 161 23 counts count NNS cord-258129-c38q6xxs 161 24 and and CC cord-258129-c38q6xxs 161 25 IL-6 IL-6 NNP cord-258129-c38q6xxs 161 26 levels level NNS cord-258129-c38q6xxs 161 27 , , , cord-258129-c38q6xxs 162 1 increased increase VBN cord-258129-c38q6xxs 162 2 neutrophil neutrophil NN cord-258129-c38q6xxs 162 3 apoptosis apoptosis NN cord-258129-c38q6xxs 162 4 and and CC cord-258129-c38q6xxs 162 5 reduced reduce VBD cord-258129-c38q6xxs 162 6 the the DT cord-258129-c38q6xxs 162 7 histological histological JJ cord-258129-c38q6xxs 162 8 severity severity NN cord-258129-c38q6xxs 162 9 of of IN cord-258129-c38q6xxs 162 10 pneumonia pneumonia NN cord-258129-c38q6xxs 162 11 as as RB cord-258129-c38q6xxs 162 12 well well RB cord-258129-c38q6xxs 162 13 as as IN cord-258129-c38q6xxs 162 14 lung lung NN cord-258129-c38q6xxs 162 15 myeloperoxidase myeloperoxidase NN cord-258129-c38q6xxs 162 16 content content NN cord-258129-c38q6xxs 162 17 ( ( -LRB- cord-258129-c38q6xxs 162 18 where where WRB cord-258129-c38q6xxs 162 19 myeloperoxidase myeloperoxidase NNP cord-258129-c38q6xxs 162 20 is be VBZ cord-258129-c38q6xxs 162 21 used use VBN cord-258129-c38q6xxs 162 22 as as IN cord-258129-c38q6xxs 162 23 a a DT cord-258129-c38q6xxs 162 24 marker marker NN cord-258129-c38q6xxs 162 25 of of IN cord-258129-c38q6xxs 162 26 neutrophil neutrophil NN cord-258129-c38q6xxs 162 27 activity activity NN cord-258129-c38q6xxs 162 28 ) ) -RRB- cord-258129-c38q6xxs 162 29 . . . cord-258129-c38q6xxs 163 1 Importantly importantly RB cord-258129-c38q6xxs 163 2 , , , cord-258129-c38q6xxs 163 3 resolvin resolvin NNP cord-258129-c38q6xxs 163 4 administration administration NNP cord-258129-c38q6xxs 163 5 reduced reduce VBD cord-258129-c38q6xxs 163 6 6 6 CD cord-258129-c38q6xxs 163 7 hr hr NN cord-258129-c38q6xxs 163 8 mortality mortality NN cord-258129-c38q6xxs 163 9 from from IN cord-258129-c38q6xxs 163 10 70 70 CD cord-258129-c38q6xxs 163 11 % % NN cord-258129-c38q6xxs 163 12 to to TO cord-258129-c38q6xxs 163 13 30 30 CD cord-258129-c38q6xxs 163 14 % % NN cord-258129-c38q6xxs 163 15 in in IN cord-258129-c38q6xxs 163 16 this this DT cord-258129-c38q6xxs 163 17 model model NN cord-258129-c38q6xxs 163 18 . . . cord-258129-c38q6xxs 164 1 In in IN cord-258129-c38q6xxs 164 2 terms term NNS cord-258129-c38q6xxs 164 3 of of IN cord-258129-c38q6xxs 164 4 a a DT cord-258129-c38q6xxs 164 5 possible possible JJ cord-258129-c38q6xxs 164 6 mechanism mechanism NN cord-258129-c38q6xxs 164 7 for for IN cord-258129-c38q6xxs 164 8 increased increase VBN cord-258129-c38q6xxs 164 9 neutrophil neutrophil NN cord-258129-c38q6xxs 164 10 apoptosis apoptosis NN cord-258129-c38q6xxs 164 11 , , , cord-258129-c38q6xxs 164 12 in in IN cord-258129-c38q6xxs 164 13 vitro vitro FW cord-258129-c38q6xxs 164 14 , , , cord-258129-c38q6xxs 164 15 resolvin resolvin NNP cord-258129-c38q6xxs 164 16 E1 E1 NNP cord-258129-c38q6xxs 164 17 mitigates mitigate VBZ cord-258129-c38q6xxs 164 18 cellular cellular JJ cord-258129-c38q6xxs 164 19 survival survival NN cord-258129-c38q6xxs 164 20 signals signal NNS cord-258129-c38q6xxs 164 21 generated generate VBN cord-258129-c38q6xxs 164 22 in in IN cord-258129-c38q6xxs 164 23 response response NN cord-258129-c38q6xxs 164 24 to to IN cord-258129-c38q6xxs 164 25 a a DT cord-258129-c38q6xxs 164 26 number number NN cord-258129-c38q6xxs 164 27 of of IN cord-258129-c38q6xxs 164 28 stimuli stimulus NNS cord-258129-c38q6xxs 164 29 relevant relevant JJ cord-258129-c38q6xxs 164 30 to to IN cord-258129-c38q6xxs 164 31 the the DT cord-258129-c38q6xxs 164 32 pathogenesis pathogenesis NN cord-258129-c38q6xxs 164 33 of of IN cord-258129-c38q6xxs 164 34 acute acute JJ cord-258129-c38q6xxs 164 35 lung lung NN cord-258129-c38q6xxs 164 36 injury injury NN cord-258129-c38q6xxs 164 37 in in IN cord-258129-c38q6xxs 164 38 E. E. NNP cord-258129-c38q6xxs 164 39 coli coli VBZ cord-258129-c38q6xxs 164 40 pneumonia pneumonia NN cord-258129-c38q6xxs 164 41 and and CC cord-258129-c38q6xxs 164 42 sepsis sepsis NN cord-258129-c38q6xxs 165 1 ( ( -LRB- cord-258129-c38q6xxs 165 2 neutrophil neutrophil NN cord-258129-c38q6xxs 165 3 myeloperoxidase myeloperoxidase NN cord-258129-c38q6xxs 165 4 , , , cord-258129-c38q6xxs 165 5 serum serum NN cord-258129-c38q6xxs 165 6 amyloid amyloid NN cord-258129-c38q6xxs 165 7 A a NN cord-258129-c38q6xxs 165 8 and and CC cord-258129-c38q6xxs 165 9 bacterial bacterial JJ cord-258129-c38q6xxs 165 10 CpG CpG NNP cord-258129-c38q6xxs 165 11 DNA DNA NNP cord-258129-c38q6xxs 165 12 ) ) -RRB- cord-258129-c38q6xxs 165 13 . . . cord-258129-c38q6xxs 166 1 Similarly similarly RB cord-258129-c38q6xxs 166 2 , , , cord-258129-c38q6xxs 166 3 15epi 15epi CD cord-258129-c38q6xxs 166 4 - - HYPH cord-258129-c38q6xxs 166 5 lipoxin lipoxin NNP cord-258129-c38q6xxs 166 6 A4 A4 NNP cord-258129-c38q6xxs 166 7 also also RB cord-258129-c38q6xxs 166 8 has have VBZ cord-258129-c38q6xxs 166 9 a a DT cord-258129-c38q6xxs 166 10 pro pro JJ cord-258129-c38q6xxs 166 11 - - JJ cord-258129-c38q6xxs 166 12 apoptotic apoptotic JJ cord-258129-c38q6xxs 166 13 effect effect NN cord-258129-c38q6xxs 166 14 on on IN cord-258129-c38q6xxs 166 15 human human JJ cord-258129-c38q6xxs 166 16 neutrophils neutrophil NNS cord-258129-c38q6xxs 166 17 and and CC cord-258129-c38q6xxs 166 18 in in IN cord-258129-c38q6xxs 166 19 a a DT cord-258129-c38q6xxs 166 20 mouse mouse NN cord-258129-c38q6xxs 166 21 model model NN cord-258129-c38q6xxs 166 22 of of IN cord-258129-c38q6xxs 166 23 E. E. NNP cord-258129-c38q6xxs 166 24 coli coli NNS cord-258129-c38q6xxs 166 25 sepsisinduced sepsisinduced NNP cord-258129-c38q6xxs 166 26 lung lung NNP cord-258129-c38q6xxs 166 27 injury injury NN cord-258129-c38q6xxs 166 28 , , , cord-258129-c38q6xxs 166 29 intravenous intravenous JJ cord-258129-c38q6xxs 166 30 lipoxin lipoxin NNP cord-258129-c38q6xxs 166 31 reduced reduce VBD cord-258129-c38q6xxs 166 32 bronchoalveolar bronchoalveolar NNP cord-258129-c38q6xxs 166 33 lavage lavage NN cord-258129-c38q6xxs 166 34 neutrophil neutrophil NN cord-258129-c38q6xxs 166 35 counts count NNS cord-258129-c38q6xxs 166 36 and and CC cord-258129-c38q6xxs 166 37 increased increase VBN cord-258129-c38q6xxs 166 38 caspase caspase NN cord-258129-c38q6xxs 166 39 - - HYPH cord-258129-c38q6xxs 166 40 mediated mediate VBN cord-258129-c38q6xxs 166 41 neutrophil neutrophil NN cord-258129-c38q6xxs 166 42 apoptosis apoptosis NN cord-258129-c38q6xxs 166 43 . . . cord-258129-c38q6xxs 167 1 35 35 CD cord-258129-c38q6xxs 167 2 _SP cord-258129-c38q6xxs 168 1 As as IN cord-258129-c38q6xxs 168 2 discussed discuss VBN cord-258129-c38q6xxs 168 3 , , , cord-258129-c38q6xxs 168 4 although although IN cord-258129-c38q6xxs 168 5 inflammation inflammation NN cord-258129-c38q6xxs 168 6 is be VBZ cord-258129-c38q6xxs 168 7 an an DT cord-258129-c38q6xxs 168 8 essential essential JJ cord-258129-c38q6xxs 168 9 response response NN cord-258129-c38q6xxs 168 10 to to IN cord-258129-c38q6xxs 168 11 infection infection NN cord-258129-c38q6xxs 168 12 , , , cord-258129-c38q6xxs 168 13 an an DT cord-258129-c38q6xxs 168 14 excessive excessive JJ cord-258129-c38q6xxs 168 15 response response NN cord-258129-c38q6xxs 168 16 is be VBZ cord-258129-c38q6xxs 169 1 detrimental detrimental JJ cord-258129-c38q6xxs 169 2 and and CC cord-258129-c38q6xxs 169 3 stromal stromal JJ cord-258129-c38q6xxs 169 4 keratitis keratitis NN cord-258129-c38q6xxs 169 5 demonstrates demonstrate VBZ cord-258129-c38q6xxs 169 6 this this DT cord-258129-c38q6xxs 169 7 . . . cord-258129-c38q6xxs 170 1 It -PRON- PRP cord-258129-c38q6xxs 170 2 is be VBZ cord-258129-c38q6xxs 170 3 an an DT cord-258129-c38q6xxs 170 4 inflammatory inflammatory JJ cord-258129-c38q6xxs 170 5 lesion lesion NN cord-258129-c38q6xxs 170 6 of of IN cord-258129-c38q6xxs 170 7 the the DT cord-258129-c38q6xxs 170 8 cornea cornea NN cord-258129-c38q6xxs 170 9 that that WDT cord-258129-c38q6xxs 170 10 is be VBZ cord-258129-c38q6xxs 170 11 a a DT cord-258129-c38q6xxs 170 12 sequela sequela NN cord-258129-c38q6xxs 170 13 of of IN cord-258129-c38q6xxs 170 14 ocular ocular JJ cord-258129-c38q6xxs 170 15 herpes herpes NN cord-258129-c38q6xxs 170 16 simplex simplex NN cord-258129-c38q6xxs 170 17 virus virus NN cord-258129-c38q6xxs 170 18 infection infection NN cord-258129-c38q6xxs 170 19 , , , cord-258129-c38q6xxs 170 20 usually usually RB cord-258129-c38q6xxs 170 21 appearing appear VBG cord-258129-c38q6xxs 170 22 1 1 CD cord-258129-c38q6xxs 170 23 week week NN cord-258129-c38q6xxs 170 24 after after IN cord-258129-c38q6xxs 170 25 primary primary JJ cord-258129-c38q6xxs 170 26 infection infection NN cord-258129-c38q6xxs 170 27 . . . cord-258129-c38q6xxs 171 1 Importantly importantly RB cord-258129-c38q6xxs 171 2 , , , cord-258129-c38q6xxs 171 3 when when WRB cord-258129-c38q6xxs 171 4 stromal stromal JJ cord-258129-c38q6xxs 171 5 keratitis keratitis NN cord-258129-c38q6xxs 171 6 manifests manifest VBZ cord-258129-c38q6xxs 171 7 , , , cord-258129-c38q6xxs 171 8 replicating replicate VBG cord-258129-c38q6xxs 171 9 virus virus NN cord-258129-c38q6xxs 171 10 can can MD cord-258129-c38q6xxs 171 11 not not RB cord-258129-c38q6xxs 171 12 be be VB cord-258129-c38q6xxs 171 13 detected detect VBN cord-258129-c38q6xxs 171 14 ; ; : cord-258129-c38q6xxs 171 15 therefore therefore RB cord-258129-c38q6xxs 171 16 the the DT cord-258129-c38q6xxs 171 17 initiating initiate VBG cord-258129-c38q6xxs 171 18 virus virus NN cord-258129-c38q6xxs 171 19 has have VBZ cord-258129-c38q6xxs 171 20 been be VBN cord-258129-c38q6xxs 171 21 cleared clear VBN cord-258129-c38q6xxs 171 22 and and CC cord-258129-c38q6xxs 171 23 the the DT cord-258129-c38q6xxs 171 24 disease disease NN cord-258129-c38q6xxs 171 25 is be VBZ cord-258129-c38q6xxs 171 26 a a DT cord-258129-c38q6xxs 171 27 consequence consequence NN cord-258129-c38q6xxs 171 28 of of IN cord-258129-c38q6xxs 171 29 non non JJ cord-258129-c38q6xxs 171 30 - - JJ cord-258129-c38q6xxs 171 31 resolving resolve VBG cord-258129-c38q6xxs 171 32 excessive excessive JJ cord-258129-c38q6xxs 171 33 inflammation inflammation NN cord-258129-c38q6xxs 171 34 . . . cord-258129-c38q6xxs 172 1 In in IN cord-258129-c38q6xxs 172 2 mice mouse NNS cord-258129-c38q6xxs 172 3 , , , cord-258129-c38q6xxs 172 4 ocular ocular JJ cord-258129-c38q6xxs 172 5 herpes herpes NN cord-258129-c38q6xxs 172 6 simplex simplex NN cord-258129-c38q6xxs 172 7 virus virus NN cord-258129-c38q6xxs 172 8 infection infection NN cord-258129-c38q6xxs 172 9 is be VBZ cord-258129-c38q6xxs 172 10 a a DT cord-258129-c38q6xxs 172 11 model model NN cord-258129-c38q6xxs 172 12 of of IN cord-258129-c38q6xxs 172 13 stromal stromal JJ cord-258129-c38q6xxs 172 14 keratitis keratitis NN cord-258129-c38q6xxs 172 15 in in IN cord-258129-c38q6xxs 172 16 humans human NNS cord-258129-c38q6xxs 172 17 . . . cord-258129-c38q6xxs 173 1 Topical topical JJ cord-258129-c38q6xxs 173 2 administration administration NN cord-258129-c38q6xxs 173 3 of of IN cord-258129-c38q6xxs 173 4 resolvin resolvin NNP cord-258129-c38q6xxs 173 5 E1 E1 NNP cord-258129-c38q6xxs 173 6 was be VBD cord-258129-c38q6xxs 173 7 able able JJ cord-258129-c38q6xxs 173 8 to to TO cord-258129-c38q6xxs 173 9 control control VB cord-258129-c38q6xxs 173 10 the the DT cord-258129-c38q6xxs 173 11 immunopathological immunopathological JJ cord-258129-c38q6xxs 173 12 manifestations manifestation NNS cord-258129-c38q6xxs 173 13 of of IN cord-258129-c38q6xxs 173 14 ocular ocular JJ cord-258129-c38q6xxs 173 15 herpes herpes NN cord-258129-c38q6xxs 173 16 simplex simplex NN cord-258129-c38q6xxs 173 17 virus virus NN cord-258129-c38q6xxs 173 18 and and CC cord-258129-c38q6xxs 173 19 reduce reduce VB cord-258129-c38q6xxs 173 20 the the DT cord-258129-c38q6xxs 173 21 severity severity NN cord-258129-c38q6xxs 173 22 of of IN cord-258129-c38q6xxs 173 23 stromal stromal JJ cord-258129-c38q6xxs 173 24 keratitis keratitis NN cord-258129-c38q6xxs 173 25 lesions lesion NNS cord-258129-c38q6xxs 173 26 . . . cord-258129-c38q6xxs 174 1 36 36 CD cord-258129-c38q6xxs 175 1 The the DT cord-258129-c38q6xxs 175 2 influx influx NN cord-258129-c38q6xxs 175 3 of of IN cord-258129-c38q6xxs 175 4 CD4 CD4 NNP cord-258129-c38q6xxs 175 5 + + CC cord-258129-c38q6xxs 175 6 T T NNP cord-258129-c38q6xxs 175 7 cells cell NNS cord-258129-c38q6xxs 175 8 and and CC cord-258129-c38q6xxs 175 9 neutrophils neutrophil NNS cord-258129-c38q6xxs 175 10 was be VBD cord-258129-c38q6xxs 175 11 reduced reduce VBN cord-258129-c38q6xxs 175 12 , , , cord-258129-c38q6xxs 175 13 as as IN cord-258129-c38q6xxs 175 14 were be VBD cord-258129-c38q6xxs 175 15 corneal corneal JJ cord-258129-c38q6xxs 175 16 levels level NNS cord-258129-c38q6xxs 175 17 of of IN cord-258129-c38q6xxs 175 18 pro pro JJ cord-258129-c38q6xxs 175 19 - - JJ cord-258129-c38q6xxs 175 20 inflammatory inflammatory JJ cord-258129-c38q6xxs 175 21 cytokines cytokine NNS cord-258129-c38q6xxs 175 22 known know VBN cord-258129-c38q6xxs 175 23 to to TO cord-258129-c38q6xxs 175 24 be be VB cord-258129-c38q6xxs 175 25 involved involve VBN cord-258129-c38q6xxs 175 26 in in IN cord-258129-c38q6xxs 175 27 the the DT cord-258129-c38q6xxs 175 28 pathogenesis pathogenesis NN cord-258129-c38q6xxs 175 29 of of IN cord-258129-c38q6xxs 175 30 stromal stromal JJ cord-258129-c38q6xxs 175 31 keratitis keratitis NN cord-258129-c38q6xxs 175 32 . . . cord-258129-c38q6xxs 176 1 Levels level NNS cord-258129-c38q6xxs 176 2 of of IN cord-258129-c38q6xxs 176 3 the the DT cord-258129-c38q6xxs 176 4 anti anti JJ cord-258129-c38q6xxs 176 5 - - JJ cord-258129-c38q6xxs 176 6 inflammatory inflammatory JJ cord-258129-c38q6xxs 176 7 cytokine cytokine NN cord-258129-c38q6xxs 176 8 IL-10 IL-10 NNP cord-258129-c38q6xxs 176 9 were be VBD cord-258129-c38q6xxs 176 10 increased increase VBN cord-258129-c38q6xxs 176 11 . . . cord-258129-c38q6xxs 177 1 Through through IN cord-258129-c38q6xxs 177 2 a a DT cord-258129-c38q6xxs 177 3 screen screen NN cord-258129-c38q6xxs 177 4 of of IN cord-258129-c38q6xxs 177 5 the the DT cord-258129-c38q6xxs 177 6 effect effect NN cord-258129-c38q6xxs 177 7 of of IN cord-258129-c38q6xxs 177 8 a a DT cord-258129-c38q6xxs 177 9 range range NN cord-258129-c38q6xxs 177 10 of of IN cord-258129-c38q6xxs 177 11 lipid lipid NN cord-258129-c38q6xxs 177 12 mediators mediator NNS cord-258129-c38q6xxs 177 13 on on IN cord-258129-c38q6xxs 177 14 the the DT cord-258129-c38q6xxs 177 15 replication replication NN cord-258129-c38q6xxs 177 16 of of IN cord-258129-c38q6xxs 177 17 H1N1 H1N1 NNP cord-258129-c38q6xxs 177 18 influenza influenza NN cord-258129-c38q6xxs 177 19 A a DT cord-258129-c38q6xxs 177 20 virus virus NN cord-258129-c38q6xxs 177 21 in in IN cord-258129-c38q6xxs 177 22 human human JJ cord-258129-c38q6xxs 177 23 lung lung NN cord-258129-c38q6xxs 177 24 epithelial epithelial NN cord-258129-c38q6xxs 177 25 cells cell NNS cord-258129-c38q6xxs 177 26 , , , cord-258129-c38q6xxs 177 27 protectin protectin NNP cord-258129-c38q6xxs 177 28 D1 D1 NNP cord-258129-c38q6xxs 177 29 was be VBD cord-258129-c38q6xxs 177 30 found find VBN cord-258129-c38q6xxs 177 31 to to TO cord-258129-c38q6xxs 177 32 significantly significantly RB cord-258129-c38q6xxs 177 33 reduce reduce VB cord-258129-c38q6xxs 177 34 viral viral JJ cord-258129-c38q6xxs 177 35 replication replication NN cord-258129-c38q6xxs 177 36 in in IN cord-258129-c38q6xxs 177 37 vitro vitro FW cord-258129-c38q6xxs 177 38 . . . cord-258129-c38q6xxs 178 1 37 37 CD cord-258129-c38q6xxs 179 1 In in IN cord-258129-c38q6xxs 179 2 a a DT cord-258129-c38q6xxs 179 3 model model NN cord-258129-c38q6xxs 179 4 of of IN cord-258129-c38q6xxs 179 5 human human JJ cord-258129-c38q6xxs 179 6 severe severe JJ cord-258129-c38q6xxs 179 7 influenza influenza NN cord-258129-c38q6xxs 179 8 , , , cord-258129-c38q6xxs 179 9 virus virus NN cord-258129-c38q6xxs 179 10 was be VBD cord-258129-c38q6xxs 179 11 introduced introduce VBN cord-258129-c38q6xxs 179 12 through through IN cord-258129-c38q6xxs 179 13 the the DT cord-258129-c38q6xxs 179 14 intratracheal intratracheal NN cord-258129-c38q6xxs 179 15 route route NN cord-258129-c38q6xxs 179 16 in in IN cord-258129-c38q6xxs 179 17 mice mouse NNS cord-258129-c38q6xxs 179 18 and and CC cord-258129-c38q6xxs 179 19 protectin protectin NNP cord-258129-c38q6xxs 179 20 D1 d1 NN cord-258129-c38q6xxs 179 21 levels level NNS cord-258129-c38q6xxs 179 22 were be VBD cord-258129-c38q6xxs 179 23 found find VBN cord-258129-c38q6xxs 179 24 to to TO cord-258129-c38q6xxs 179 25 be be VB cord-258129-c38q6xxs 179 26 reduced reduce VBN cord-258129-c38q6xxs 179 27 , , , cord-258129-c38q6xxs 179 28 suggesting suggest VBG cord-258129-c38q6xxs 179 29 that that IN cord-258129-c38q6xxs 179 30 endogenous endogenous JJ cord-258129-c38q6xxs 179 31 production production NN cord-258129-c38q6xxs 179 32 was be VBD cord-258129-c38q6xxs 179 33 suppressed suppress VBN cord-258129-c38q6xxs 179 34 by by IN cord-258129-c38q6xxs 179 35 the the DT cord-258129-c38q6xxs 179 36 virus virus NN cord-258129-c38q6xxs 179 37 . . . cord-258129-c38q6xxs 180 1 When when WRB cord-258129-c38q6xxs 180 2 other other JJ cord-258129-c38q6xxs 180 3 influenza influenza NN cord-258129-c38q6xxs 180 4 A a DT cord-258129-c38q6xxs 180 5 virus virus NN cord-258129-c38q6xxs 180 6 strains strain NNS cord-258129-c38q6xxs 180 7 were be VBD cord-258129-c38q6xxs 180 8 tested test VBN cord-258129-c38q6xxs 180 9 , , , cord-258129-c38q6xxs 180 10 the the DT cord-258129-c38q6xxs 180 11 reduction reduction NN cord-258129-c38q6xxs 180 12 in in IN cord-258129-c38q6xxs 180 13 protectin protectin NNP cord-258129-c38q6xxs 180 14 levels level NNS cord-258129-c38q6xxs 180 15 was be VBD cord-258129-c38q6xxs 180 16 found find VBN cord-258129-c38q6xxs 180 17 to to TO cord-258129-c38q6xxs 180 18 inversely inversely RB cord-258129-c38q6xxs 180 19 correlate correlate VB cord-258129-c38q6xxs 180 20 with with IN cord-258129-c38q6xxs 180 21 the the DT cord-258129-c38q6xxs 180 22 virulence virulence NN cord-258129-c38q6xxs 180 23 of of IN cord-258129-c38q6xxs 180 24 the the DT cord-258129-c38q6xxs 180 25 virus virus NN cord-258129-c38q6xxs 180 26 strain strain NN cord-258129-c38q6xxs 180 27 used use VBN cord-258129-c38q6xxs 180 28 . . . cord-258129-c38q6xxs 181 1 In in IN cord-258129-c38q6xxs 181 2 this this DT cord-258129-c38q6xxs 181 3 same same JJ cord-258129-c38q6xxs 181 4 model model NN cord-258129-c38q6xxs 181 5 of of IN cord-258129-c38q6xxs 181 6 severe severe JJ cord-258129-c38q6xxs 181 7 influenza influenza NN cord-258129-c38q6xxs 181 8 , , , cord-258129-c38q6xxs 181 9 intravenous intravenous JJ cord-258129-c38q6xxs 181 10 administration administration NN cord-258129-c38q6xxs 181 11 of of IN cord-258129-c38q6xxs 181 12 protectin protectin NNP cord-258129-c38q6xxs 181 13 increased increase VBD cord-258129-c38q6xxs 181 14 survival survival NN cord-258129-c38q6xxs 181 15 . . . cord-258129-c38q6xxs 182 1 Administration Administration NNP cord-258129-c38q6xxs 182 2 of of IN cord-258129-c38q6xxs 182 3 resolvin resolvin NNP cord-258129-c38q6xxs 182 4 and and CC cord-258129-c38q6xxs 182 5 lipoxin lipoxin NNP cord-258129-c38q6xxs 182 6 had have VBD cord-258129-c38q6xxs 182 7 no no DT cord-258129-c38q6xxs 182 8 effect effect NN cord-258129-c38q6xxs 182 9 . . . cord-258129-c38q6xxs 183 1 Significantly significantly RB cord-258129-c38q6xxs 183 2 , , , cord-258129-c38q6xxs 183 3 the the DT cord-258129-c38q6xxs 183 4 protective protective JJ cord-258129-c38q6xxs 183 5 effect effect NN cord-258129-c38q6xxs 183 6 of of IN cord-258129-c38q6xxs 183 7 protectin protectin NNP cord-258129-c38q6xxs 183 8 was be VBD cord-258129-c38q6xxs 183 9 still still RB cord-258129-c38q6xxs 183 10 seen see VBN cord-258129-c38q6xxs 183 11 when when WRB cord-258129-c38q6xxs 183 12 administered administer VBN cord-258129-c38q6xxs 183 13 2 2 CD cord-258129-c38q6xxs 183 14 days day NNS cord-258129-c38q6xxs 183 15 after after IN cord-258129-c38q6xxs 183 16 the the DT cord-258129-c38q6xxs 183 17 start start NN cord-258129-c38q6xxs 183 18 of of IN cord-258129-c38q6xxs 183 19 infection infection NN cord-258129-c38q6xxs 183 20 . . . cord-258129-c38q6xxs 184 1 Lipoxins Lipoxins NNP cord-258129-c38q6xxs 184 2 , , , cord-258129-c38q6xxs 184 3 resolvins resolvins NNP cord-258129-c38q6xxs 184 4 and and CC cord-258129-c38q6xxs 184 5 protectins protectin NNS cord-258129-c38q6xxs 184 6 are be VBP cord-258129-c38q6xxs 184 7 endogenous endogenous JJ cord-258129-c38q6xxs 184 8 lipid lipid NN cord-258129-c38q6xxs 184 9 mediators mediator NNS cord-258129-c38q6xxs 184 10 with with IN cord-258129-c38q6xxs 184 11 a a DT cord-258129-c38q6xxs 184 12 pro pro JJ cord-258129-c38q6xxs 184 13 - - JJ cord-258129-c38q6xxs 184 14 resolution resolution JJ cord-258129-c38q6xxs 184 15 effect effect NN cord-258129-c38q6xxs 184 16 in in IN cord-258129-c38q6xxs 184 17 inflammation inflammation NN cord-258129-c38q6xxs 184 18 . . . cord-258129-c38q6xxs 185 1 Much much JJ cord-258129-c38q6xxs 185 2 work work NN cord-258129-c38q6xxs 185 3 has have VBZ cord-258129-c38q6xxs 185 4 focused focus VBN cord-258129-c38q6xxs 185 5 on on IN cord-258129-c38q6xxs 185 6 their -PRON- PRP$ cord-258129-c38q6xxs 185 7 now now RB cord-258129-c38q6xxs 185 8 well well RB cord-258129-c38q6xxs 185 9 - - HYPH cord-258129-c38q6xxs 185 10 recognized recognize VBN cord-258129-c38q6xxs 185 11 role role NN cord-258129-c38q6xxs 185 12 in in IN cord-258129-c38q6xxs 185 13 allergic allergic JJ cord-258129-c38q6xxs 185 14 airway airway NN cord-258129-c38q6xxs 185 15 inflammation inflammation NN cord-258129-c38q6xxs 185 16 . . . cord-258129-c38q6xxs 186 1 38 38 CD cord-258129-c38q6xxs 187 1 However however RB cord-258129-c38q6xxs 187 2 , , , cord-258129-c38q6xxs 187 3 an an DT cord-258129-c38q6xxs 187 4 emerging emerge VBG cord-258129-c38q6xxs 187 5 theme theme NN cord-258129-c38q6xxs 187 6 is be VBZ cord-258129-c38q6xxs 187 7 their -PRON- PRP$ cord-258129-c38q6xxs 187 8 importance importance NN cord-258129-c38q6xxs 187 9 in in IN cord-258129-c38q6xxs 187 10 the the DT cord-258129-c38q6xxs 187 11 resolution resolution NN cord-258129-c38q6xxs 187 12 of of IN cord-258129-c38q6xxs 187 13 infection infection NN cord-258129-c38q6xxs 187 14 and and CC cord-258129-c38q6xxs 187 15 associated associated JJ cord-258129-c38q6xxs 187 16 inflammation inflammation NN cord-258129-c38q6xxs 187 17 , , , cord-258129-c38q6xxs 187 18 and and CC cord-258129-c38q6xxs 187 19 this this DT cord-258129-c38q6xxs 187 20 article article NN cord-258129-c38q6xxs 187 21 has have VBZ cord-258129-c38q6xxs 187 22 reviewed review VBN cord-258129-c38q6xxs 187 23 emerging emerge VBG cord-258129-c38q6xxs 187 24 data datum NNS cord-258129-c38q6xxs 187 25 relevant relevant JJ cord-258129-c38q6xxs 187 26 to to IN cord-258129-c38q6xxs 187 27 this this DT cord-258129-c38q6xxs 187 28 . . . cord-258129-c38q6xxs 188 1 Table table NN cord-258129-c38q6xxs 188 2 1 1 CD cord-258129-c38q6xxs 188 3 summarizes summarize VBZ cord-258129-c38q6xxs 188 4 what what WP cord-258129-c38q6xxs 188 5 has have VBZ cord-258129-c38q6xxs 188 6 been be VBN cord-258129-c38q6xxs 188 7 learnt learn VBN cord-258129-c38q6xxs 188 8 from from IN cord-258129-c38q6xxs 188 9 animal animal NN cord-258129-c38q6xxs 188 10 studies study NNS cord-258129-c38q6xxs 188 11 . . . cord-258129-c38q6xxs 189 1 The the DT cord-258129-c38q6xxs 189 2 role role NN cord-258129-c38q6xxs 189 3 of of IN cord-258129-c38q6xxs 189 4 lipoxins lipoxin NNS cord-258129-c38q6xxs 189 5 may may MD cord-258129-c38q6xxs 189 6 vary vary VB cord-258129-c38q6xxs 189 7 depending depend VBG cord-258129-c38q6xxs 189 8 on on IN cord-258129-c38q6xxs 189 9 the the DT cord-258129-c38q6xxs 189 10 specific specific JJ cord-258129-c38q6xxs 189 11 infection infection NN cord-258129-c38q6xxs 189 12 . . . cord-258129-c38q6xxs 190 1 In in IN cord-258129-c38q6xxs 190 2 a a DT cord-258129-c38q6xxs 190 3 mouse mouse NN cord-258129-c38q6xxs 190 4 model model NN cord-258129-c38q6xxs 190 5 of of IN cord-258129-c38q6xxs 190 6 M. M. NNP cord-258129-c38q6xxs 190 7 tuberculosis tuberculosis NN cord-258129-c38q6xxs 190 8 infection infection NN cord-258129-c38q6xxs 190 9 , , , cord-258129-c38q6xxs 190 10 transgenic transgenic JJ cord-258129-c38q6xxs 190 11 mice mouse NNS cord-258129-c38q6xxs 190 12 unable unable JJ cord-258129-c38q6xxs 190 13 to to TO cord-258129-c38q6xxs 190 14 produce produce VB cord-258129-c38q6xxs 190 15 lipoxin lipoxin NNP cord-258129-c38q6xxs 190 16 were be VBD cord-258129-c38q6xxs 190 17 able able JJ cord-258129-c38q6xxs 190 18 to to TO cord-258129-c38q6xxs 190 19 control control VB cord-258129-c38q6xxs 190 20 the the DT cord-258129-c38q6xxs 190 21 bacteria bacteria NNS cord-258129-c38q6xxs 190 22 better better RB cord-258129-c38q6xxs 190 23 with with IN cord-258129-c38q6xxs 190 24 reduced reduce VBN cord-258129-c38q6xxs 190 25 mortality mortality NN cord-258129-c38q6xxs 190 26 in in IN cord-258129-c38q6xxs 190 27 comparison comparison NN cord-258129-c38q6xxs 190 28 to to IN cord-258129-c38q6xxs 190 29 wild wild JJ cord-258129-c38q6xxs 190 30 - - HYPH cord-258129-c38q6xxs 190 31 type type NN cord-258129-c38q6xxs 190 32 , , , cord-258129-c38q6xxs 190 33 and and CC cord-258129-c38q6xxs 190 34 expressed express VBD cord-258129-c38q6xxs 190 35 IL-12 IL-12 NNP cord-258129-c38q6xxs 190 36 , , , cord-258129-c38q6xxs 190 37 IFN IFN NNP cord-258129-c38q6xxs 190 38 - - HYPH cord-258129-c38q6xxs 190 39 c c NNP cord-258129-c38q6xxs 190 40 and and CC cord-258129-c38q6xxs 190 41 inducible inducible JJ cord-258129-c38q6xxs 190 42 nitric nitric NN cord-258129-c38q6xxs 190 43 oxide oxide NN cord-258129-c38q6xxs 190 44 synthase synthase NN cord-258129-c38q6xxs 190 45 2 2 CD cord-258129-c38q6xxs 190 46 at at IN cord-258129-c38q6xxs 190 47 higher high JJR cord-258129-c38q6xxs 190 48 levels level NNS cord-258129-c38q6xxs 190 49 . . . cord-258129-c38q6xxs 191 1 In in IN cord-258129-c38q6xxs 191 2 contrast contrast NN cord-258129-c38q6xxs 191 3 , , , cord-258129-c38q6xxs 191 4 using use VBG cord-258129-c38q6xxs 191 5 the the DT cord-258129-c38q6xxs 191 6 same same JJ cord-258129-c38q6xxs 191 7 transgenic transgenic JJ cord-258129-c38q6xxs 191 8 mice mouse NNS cord-258129-c38q6xxs 191 9 in in IN cord-258129-c38q6xxs 191 10 T. t. NN cord-258129-c38q6xxs 191 11 gondii gondii NN cord-258129-c38q6xxs 191 12 infection infection NN cord-258129-c38q6xxs 191 13 , , , cord-258129-c38q6xxs 191 14 mortality mortality NN cord-258129-c38q6xxs 191 15 was be VBD cord-258129-c38q6xxs 191 16 higher high JJR cord-258129-c38q6xxs 191 17 despite despite IN cord-258129-c38q6xxs 191 18 a a DT cord-258129-c38q6xxs 191 19 lower low JJR cord-258129-c38q6xxs 191 20 parasitic parasitic JJ cord-258129-c38q6xxs 191 21 burden burden NN cord-258129-c38q6xxs 191 22 and and CC cord-258129-c38q6xxs 191 23 this this DT cord-258129-c38q6xxs 191 24 was be VBD cord-258129-c38q6xxs 191 25 attributed attribute VBN cord-258129-c38q6xxs 191 26 to to IN cord-258129-c38q6xxs 191 27 excessive excessive JJ cord-258129-c38q6xxs 191 28 cytokine cytokine NN cord-258129-c38q6xxs 191 29 - - HYPH cord-258129-c38q6xxs 191 30 mediated mediate VBN cord-258129-c38q6xxs 191 31 tissue tissue NN cord-258129-c38q6xxs 191 32 damage damage NN cord-258129-c38q6xxs 191 33 . . . cord-258129-c38q6xxs 192 1 Beneficial beneficial JJ cord-258129-c38q6xxs 192 2 effects effect NNS cord-258129-c38q6xxs 192 3 were be VBD cord-258129-c38q6xxs 192 4 also also RB cord-258129-c38q6xxs 192 5 seen see VBN cord-258129-c38q6xxs 192 6 in in IN cord-258129-c38q6xxs 192 7 a a DT cord-258129-c38q6xxs 192 8 mouse mouse NN cord-258129-c38q6xxs 192 9 model model NN cord-258129-c38q6xxs 192 10 of of IN cord-258129-c38q6xxs 192 11 Trypanosoma Trypanosoma NNP cord-258129-c38q6xxs 192 12 cruzi cruzi NN cord-258129-c38q6xxs 192 13 infection infection NN cord-258129-c38q6xxs 192 14 and and CC cord-258129-c38q6xxs 192 15 cerebral cerebral JJ cord-258129-c38q6xxs 192 16 malaria malaria NN cord-258129-c38q6xxs 192 17 . . . cord-258129-c38q6xxs 193 1 Topical topical JJ cord-258129-c38q6xxs 193 2 lipoxin lipoxin NN cord-258129-c38q6xxs 193 3 abrogated abrogate VBD cord-258129-c38q6xxs 193 4 the the DT cord-258129-c38q6xxs 193 5 tissue tissue NN cord-258129-c38q6xxs 193 6 and and CC cord-258129-c38q6xxs 193 7 bone bone NN cord-258129-c38q6xxs 193 8 damage damage NN cord-258129-c38q6xxs 193 9 seen see VBN cord-258129-c38q6xxs 193 10 in in IN cord-258129-c38q6xxs 193 11 a a DT cord-258129-c38q6xxs 193 12 rabbit rabbit NN cord-258129-c38q6xxs 193 13 model model NN cord-258129-c38q6xxs 193 14 of of IN cord-258129-c38q6xxs 193 15 P. P. NNP cord-258129-c38q6xxs 193 16 gingivalis gingivalis NNP cord-258129-c38q6xxs 193 17 periodontitis periodontitis NN cord-258129-c38q6xxs 193 18 . . . cord-258129-c38q6xxs 194 1 Therefore therefore RB cord-258129-c38q6xxs 194 2 , , , cord-258129-c38q6xxs 194 3 the the DT cord-258129-c38q6xxs 194 4 proresolution proresolution NN cord-258129-c38q6xxs 194 5 effects effect NNS cord-258129-c38q6xxs 194 6 of of IN cord-258129-c38q6xxs 194 7 lipoxin lipoxin NNP cord-258129-c38q6xxs 194 8 may may MD cord-258129-c38q6xxs 194 9 be be VB cord-258129-c38q6xxs 194 10 advantageous advantageous JJ cord-258129-c38q6xxs 194 11 in in IN cord-258129-c38q6xxs 194 12 protecting protect VBG cord-258129-c38q6xxs 194 13 the the DT cord-258129-c38q6xxs 194 14 host host NN cord-258129-c38q6xxs 194 15 from from IN cord-258129-c38q6xxs 194 16 the the DT cord-258129-c38q6xxs 194 17 damaging damaging JJ cord-258129-c38q6xxs 194 18 effect effect NN cord-258129-c38q6xxs 194 19 of of IN cord-258129-c38q6xxs 194 20 excessive excessive JJ cord-258129-c38q6xxs 194 21 inflammation inflammation NN cord-258129-c38q6xxs 194 22 , , , cord-258129-c38q6xxs 194 23 but but CC cord-258129-c38q6xxs 194 24 this this DT cord-258129-c38q6xxs 194 25 benefit benefit NN cord-258129-c38q6xxs 194 26 may may MD cord-258129-c38q6xxs 194 27 be be VB cord-258129-c38q6xxs 194 28 out out RB cord-258129-c38q6xxs 194 29 - - HYPH cord-258129-c38q6xxs 194 30 weighed weigh VBN cord-258129-c38q6xxs 194 31 in in IN cord-258129-c38q6xxs 194 32 some some DT cord-258129-c38q6xxs 194 33 situations situation NNS cord-258129-c38q6xxs 194 34 by by IN cord-258129-c38q6xxs 194 35 permitting permit VBG cord-258129-c38q6xxs 194 36 unchecked unchecked JJ cord-258129-c38q6xxs 194 37 pathogen pathogen NN cord-258129-c38q6xxs 194 38 replication replication NN cord-258129-c38q6xxs 194 39 ( ( -LRB- cord-258129-c38q6xxs 194 40 as as IN cord-258129-c38q6xxs 194 41 seen see VBN cord-258129-c38q6xxs 194 42 in in IN cord-258129-c38q6xxs 194 43 the the DT cord-258129-c38q6xxs 194 44 model model NN cord-258129-c38q6xxs 194 45 of of IN cord-258129-c38q6xxs 194 46 M. M. NNP cord-258129-c38q6xxs 194 47 tuberculosis tuberculosis NN cord-258129-c38q6xxs 194 48 ) ) -RRB- cord-258129-c38q6xxs 194 49 . . . cord-258129-c38q6xxs 195 1 The the DT cord-258129-c38q6xxs 195 2 finding finding NN cord-258129-c38q6xxs 195 3 that that DT cord-258129-c38q6xxs 195 4 administration administration NN cord-258129-c38q6xxs 195 5 of of IN cord-258129-c38q6xxs 195 6 lipoxin lipoxin NNP cord-258129-c38q6xxs 195 7 enhances enhance VBZ cord-258129-c38q6xxs 195 8 survival survival NN cord-258129-c38q6xxs 195 9 in in IN cord-258129-c38q6xxs 195 10 a a DT cord-258129-c38q6xxs 195 11 mouse mouse NN cord-258129-c38q6xxs 195 12 model model NN cord-258129-c38q6xxs 195 13 of of IN cord-258129-c38q6xxs 195 14 cerebral cerebral JJ cord-258129-c38q6xxs 195 15 malaria malaria NN cord-258129-c38q6xxs 195 16 suggests suggest VBZ cord-258129-c38q6xxs 195 17 a a DT cord-258129-c38q6xxs 195 18 potential potential JJ cord-258129-c38q6xxs 195 19 new new JJ cord-258129-c38q6xxs 195 20 therapeutic therapeutic JJ cord-258129-c38q6xxs 195 21 strategy strategy NN cord-258129-c38q6xxs 195 22 for for IN cord-258129-c38q6xxs 195 23 human human JJ cord-258129-c38q6xxs 195 24 cerebral cerebral JJ cord-258129-c38q6xxs 195 25 malaria malaria NN cord-258129-c38q6xxs 195 26 . . . cord-258129-c38q6xxs 196 1 The the DT cord-258129-c38q6xxs 196 2 effects effect NNS cord-258129-c38q6xxs 196 3 of of IN cord-258129-c38q6xxs 196 4 resolvin resolvin NNP cord-258129-c38q6xxs 196 5 were be VBD cord-258129-c38q6xxs 196 6 investigated investigate VBN cord-258129-c38q6xxs 196 7 in in IN cord-258129-c38q6xxs 196 8 a a DT cord-258129-c38q6xxs 196 9 number number NN cord-258129-c38q6xxs 196 10 of of IN cord-258129-c38q6xxs 196 11 mouse mouse NN cord-258129-c38q6xxs 196 12 models model NNS cord-258129-c38q6xxs 196 13 of of IN cord-258129-c38q6xxs 196 14 systemic systemic JJ cord-258129-c38q6xxs 196 15 bacterial bacterial JJ cord-258129-c38q6xxs 196 16 infection infection NN cord-258129-c38q6xxs 196 17 , , , cord-258129-c38q6xxs 196 18 and and CC cord-258129-c38q6xxs 196 19 were be VBD cord-258129-c38q6xxs 196 20 found find VBN cord-258129-c38q6xxs 196 21 to to TO cord-258129-c38q6xxs 196 22 enhance enhance VB cord-258129-c38q6xxs 196 23 phagocytic phagocytic JJ cord-258129-c38q6xxs 196 24 clearance clearance NN cord-258129-c38q6xxs 196 25 of of IN cord-258129-c38q6xxs 196 26 bacteria bacteria NNS cord-258129-c38q6xxs 196 27 , , , cord-258129-c38q6xxs 196 28 reduce reduce VB cord-258129-c38q6xxs 196 29 neutrophil neutrophil NN cord-258129-c38q6xxs 196 30 influx influx NN cord-258129-c38q6xxs 196 31 and and CC cord-258129-c38q6xxs 196 32 inflammation inflammation NN cord-258129-c38q6xxs 196 33 severity severity NN cord-258129-c38q6xxs 196 34 , , , cord-258129-c38q6xxs 196 35 promote promote VB cord-258129-c38q6xxs 196 36 neutrophil neutrophil NN cord-258129-c38q6xxs 196 37 apoptosis apoptosis NN cord-258129-c38q6xxs 196 38 and and CC cord-258129-c38q6xxs 196 39 clearance clearance NN cord-258129-c38q6xxs 196 40 , , , cord-258129-c38q6xxs 196 41 modulate modulate VB cord-258129-c38q6xxs 196 42 neutrophil neutrophil NN cord-258129-c38q6xxs 196 43 chemotaxis chemotaxis NN cord-258129-c38q6xxs 196 44 and and CC cord-258129-c38q6xxs 196 45 importantly importantly RB cord-258129-c38q6xxs 196 46 , , , cord-258129-c38q6xxs 196 47 reduce reduce VB cord-258129-c38q6xxs 196 48 mortality mortality NN cord-258129-c38q6xxs 196 49 . . . cord-258129-c38q6xxs 197 1 Interestingly interestingly RB cord-258129-c38q6xxs 197 2 , , , cord-258129-c38q6xxs 197 3 resolvin resolvin NNP cord-258129-c38q6xxs 197 4 administration administration NNP cord-258129-c38q6xxs 197 5 also also RB cord-258129-c38q6xxs 197 6 enhanced enhance VBD cord-258129-c38q6xxs 197 7 the the DT cord-258129-c38q6xxs 197 8 antibacterial antibacterial JJ cord-258129-c38q6xxs 197 9 effect effect NN cord-258129-c38q6xxs 197 10 of of IN cord-258129-c38q6xxs 197 11 ciprofloxacin ciprofloxacin NN cord-258129-c38q6xxs 197 12 ( ( -LRB- cord-258129-c38q6xxs 197 13 in in IN cord-258129-c38q6xxs 197 14 E. E. NNP cord-258129-c38q6xxs 197 15 coli coli NNS cord-258129-c38q6xxs 197 16 peritonitis peritonitis NN cord-258129-c38q6xxs 197 17 ) ) -RRB- cord-258129-c38q6xxs 197 18 and and CC cord-258129-c38q6xxs 197 19 vancomycin vancomycin FW cord-258129-c38q6xxs 197 20 ( ( -LRB- cord-258129-c38q6xxs 197 21 in in IN cord-258129-c38q6xxs 197 22 Staphylococcus Staphylococcus NNP cord-258129-c38q6xxs 197 23 aureus aureus NN cord-258129-c38q6xxs 197 24 skin skin NN cord-258129-c38q6xxs 197 25 infection infection NN cord-258129-c38q6xxs 197 26 ) ) -RRB- cord-258129-c38q6xxs 197 27 when when WRB cord-258129-c38q6xxs 197 28 the the DT cord-258129-c38q6xxs 197 29 antimicrobial antimicrobial NN cord-258129-c38q6xxs 197 30 was be VBD cord-258129-c38q6xxs 197 31 administered administer VBN cord-258129-c38q6xxs 197 32 at at IN cord-258129-c38q6xxs 197 33 a a DT cord-258129-c38q6xxs 197 34 sub sub JJ cord-258129-c38q6xxs 197 35 - - JJ cord-258129-c38q6xxs 197 36 optimal optimal JJ cord-258129-c38q6xxs 197 37 concentration concentration NN cord-258129-c38q6xxs 197 38 . . . cord-258129-c38q6xxs 198 1 Topical topical JJ cord-258129-c38q6xxs 198 2 resolvin resolvin NN cord-258129-c38q6xxs 198 3 application application NN cord-258129-c38q6xxs 198 4 also also RB cord-258129-c38q6xxs 198 5 reduced reduce VBD cord-258129-c38q6xxs 198 6 the the DT cord-258129-c38q6xxs 198 7 severity severity NN cord-258129-c38q6xxs 198 8 of of IN cord-258129-c38q6xxs 198 9 herpes herpes NNP cord-258129-c38q6xxs 198 10 simplex simplex NNP cord-258129-c38q6xxs 198 11 virus virus NN cord-258129-c38q6xxs 198 12 ocular ocular JJ cord-258129-c38q6xxs 198 13 infection infection NN cord-258129-c38q6xxs 198 14 in in IN cord-258129-c38q6xxs 198 15 mice mouse NNS cord-258129-c38q6xxs 198 16 . . . cord-258129-c38q6xxs 199 1 Finally finally RB cord-258129-c38q6xxs 199 2 , , , cord-258129-c38q6xxs 199 3 protectin protectin NNP cord-258129-c38q6xxs 199 4 was be VBD cord-258129-c38q6xxs 199 5 found find VBN cord-258129-c38q6xxs 199 6 to to TO cord-258129-c38q6xxs 199 7 increase increase VB cord-258129-c38q6xxs 199 8 survival survival NN cord-258129-c38q6xxs 199 9 in in IN cord-258129-c38q6xxs 199 10 a a DT cord-258129-c38q6xxs 199 11 mouse mouse NN cord-258129-c38q6xxs 199 12 model model NN cord-258129-c38q6xxs 199 13 of of IN cord-258129-c38q6xxs 199 14 severe severe JJ cord-258129-c38q6xxs 199 15 influenza influenza NN cord-258129-c38q6xxs 199 16 , , , cord-258129-c38q6xxs 199 17 even even RB cord-258129-c38q6xxs 199 18 when when WRB cord-258129-c38q6xxs 199 19 administered administer VBN cord-258129-c38q6xxs 199 20 2 2 CD cord-258129-c38q6xxs 199 21 days day NNS cord-258129-c38q6xxs 199 22 after after IN cord-258129-c38q6xxs 199 23 infection infection NN cord-258129-c38q6xxs 199 24 . . . cord-258129-c38q6xxs 200 1 Given give VBN cord-258129-c38q6xxs 200 2 the the DT cord-258129-c38q6xxs 200 3 well well RB cord-258129-c38q6xxs 200 4 - - HYPH cord-258129-c38q6xxs 200 5 recognized recognize VBN cord-258129-c38q6xxs 200 6 importance importance NN cord-258129-c38q6xxs 200 7 of of IN cord-258129-c38q6xxs 200 8 these these DT cord-258129-c38q6xxs 200 9 mediators mediator NNS cord-258129-c38q6xxs 200 10 in in IN cord-258129-c38q6xxs 200 11 allergic allergic JJ cord-258129-c38q6xxs 200 12 airway airway NN cord-258129-c38q6xxs 200 13 inflammation inflammation NN cord-258129-c38q6xxs 200 14 , , , cord-258129-c38q6xxs 200 15 it -PRON- PRP cord-258129-c38q6xxs 200 16 is be VBZ cord-258129-c38q6xxs 200 17 interesting interesting JJ cord-258129-c38q6xxs 200 18 to to TO cord-258129-c38q6xxs 200 19 consider consider VB cord-258129-c38q6xxs 200 20 how how WRB cord-258129-c38q6xxs 200 21 their -PRON- PRP$ cord-258129-c38q6xxs 200 22 regulation regulation NN cord-258129-c38q6xxs 200 23 may may MD cord-258129-c38q6xxs 200 24 be be VB cord-258129-c38q6xxs 200 25 disturbed disturb VBN cord-258129-c38q6xxs 200 26 in in IN cord-258129-c38q6xxs 200 27 states state NNS cord-258129-c38q6xxs 200 28 of of IN cord-258129-c38q6xxs 200 29 airway airway JJ cord-258129-c38q6xxs 200 30 inflammation inflammation NN cord-258129-c38q6xxs 200 31 induced induce VBN cord-258129-c38q6xxs 200 32 by by IN cord-258129-c38q6xxs 200 33 infection infection NN cord-258129-c38q6xxs 200 34 , , , cord-258129-c38q6xxs 200 35 for for IN cord-258129-c38q6xxs 200 36 examples example NNS cord-258129-c38q6xxs 200 37 acute acute JJ cord-258129-c38q6xxs 200 38 respiratory respiratory JJ cord-258129-c38q6xxs 200 39 distress distress NN cord-258129-c38q6xxs 200 40 syndrome syndrome NN cord-258129-c38q6xxs 200 41 . . . cord-258129-c38q6xxs 201 1 Notably notably RB cord-258129-c38q6xxs 201 2 , , , cord-258129-c38q6xxs 201 3 pulmonary pulmonary JJ cord-258129-c38q6xxs 201 4 production production NN cord-258129-c38q6xxs 201 5 of of IN cord-258129-c38q6xxs 201 6 protectin protectin NNP cord-258129-c38q6xxs 201 7 was be VBD cord-258129-c38q6xxs 201 8 found find VBN cord-258129-c38q6xxs 201 9 to to TO cord-258129-c38q6xxs 201 10 be be VB cord-258129-c38q6xxs 201 11 suppressed suppress VBN cord-258129-c38q6xxs 201 12 by by IN cord-258129-c38q6xxs 201 13 highly highly RB cord-258129-c38q6xxs 201 14 pathogenic pathogenic JJ cord-258129-c38q6xxs 201 15 influenza influenza NN cord-258129-c38q6xxs 201 16 A a DT cord-258129-c38q6xxs 201 17 strains strain NNS cord-258129-c38q6xxs 201 18 . . . cord-258129-c38q6xxs 202 1 37 37 CD cord-258129-c38q6xxs 202 2 Evidence evidence NN cord-258129-c38q6xxs 202 3 from from IN cord-258129-c38q6xxs 202 4 Cilloniz Cilloniz NNP cord-258129-c38q6xxs 202 5 et et NNP cord-258129-c38q6xxs 202 6 al al NNP cord-258129-c38q6xxs 202 7 . . . cord-258129-c38q6xxs 203 1 12 12 CD cord-258129-c38q6xxs 203 2 suggests suggest VBZ cord-258129-c38q6xxs 203 3 that that IN cord-258129-c38q6xxs 203 4 lipoxin lipoxin NN cord-258129-c38q6xxs 203 5 - - HYPH cord-258129-c38q6xxs 203 6 mediated mediate VBN cord-258129-c38q6xxs 203 7 activity activity NN cord-258129-c38q6xxs 203 8 is be VBZ cord-258129-c38q6xxs 203 9 also also RB cord-258129-c38q6xxs 203 10 altered alter VBN cord-258129-c38q6xxs 203 11 during during IN cord-258129-c38q6xxs 203 12 influenza influenza NN cord-258129-c38q6xxs 203 13 A a DT cord-258129-c38q6xxs 203 14 virus virus NN cord-258129-c38q6xxs 203 15 infection infection NN cord-258129-c38q6xxs 203 16 . . . cord-258129-c38q6xxs 204 1 Disturbed Disturbed NNP cord-258129-c38q6xxs 204 2 lipoxin lipoxin NNP cord-258129-c38q6xxs 204 3 regulation regulation NN cord-258129-c38q6xxs 204 4 could could MD cord-258129-c38q6xxs 204 5 have have VB cord-258129-c38q6xxs 204 6 a a DT cord-258129-c38q6xxs 204 7 role role NN cord-258129-c38q6xxs 204 8 in in IN cord-258129-c38q6xxs 204 9 the the DT cord-258129-c38q6xxs 204 10 predisposition predisposition NN cord-258129-c38q6xxs 204 11 towards towards IN cord-258129-c38q6xxs 204 12 asthma asthma NN cord-258129-c38q6xxs 204 13 seen see VBN cord-258129-c38q6xxs 204 14 in in IN cord-258129-c38q6xxs 204 15 infants infant NNS cord-258129-c38q6xxs 204 16 following follow VBG cord-258129-c38q6xxs 204 17 RSV RSV NNP cord-258129-c38q6xxs 204 18 bronchiolitis bronchiolitis NN cord-258129-c38q6xxs 204 19 , , , cord-258129-c38q6xxs 204 20 39 39 CD cord-258129-c38q6xxs 204 21 , , , cord-258129-c38q6xxs 204 22 40 40 CD cord-258129-c38q6xxs 204 23 especially especially RB cord-258129-c38q6xxs 204 24 when when WRB cord-258129-c38q6xxs 204 25 considering consider VBG cord-258129-c38q6xxs 204 26 the the DT cord-258129-c38q6xxs 204 27 finding finding NN cord-258129-c38q6xxs 204 28 that that IN cord-258129-c38q6xxs 204 29 mice mouse NNS cord-258129-c38q6xxs 204 30 unable unable JJ cord-258129-c38q6xxs 204 31 to to TO cord-258129-c38q6xxs 204 32 synthesize synthesize VB cord-258129-c38q6xxs 204 33 lipoxin lipoxin NNP cord-258129-c38q6xxs 204 34 fail fail VB cord-258129-c38q6xxs 204 35 to to TO cord-258129-c38q6xxs 204 36 elicit elicit VB cord-258129-c38q6xxs 204 37 alternative alternative JJ cord-258129-c38q6xxs 204 38 macrophage macrophage NN cord-258129-c38q6xxs 204 39 differentiation differentiation NN cord-258129-c38q6xxs 204 40 , , , cord-258129-c38q6xxs 204 41 required require VBN cord-258129-c38q6xxs 204 42 for for IN cord-258129-c38q6xxs 204 43 the the DT cord-258129-c38q6xxs 204 44 resolution resolution NN cord-258129-c38q6xxs 204 45 of of IN cord-258129-c38q6xxs 204 46 RSV RSV NNP cord-258129-c38q6xxs 204 47 disease disease NN cord-258129-c38q6xxs 204 48 . . . cord-258129-c38q6xxs 205 1 15 15 CD cord-258129-c38q6xxs 205 2 , , , cord-258129-c38q6xxs 205 3 16 16 CD cord-258129-c38q6xxs 206 1 If if IN cord-258129-c38q6xxs 206 2 the the DT cord-258129-c38q6xxs 206 3 beneficial beneficial JJ cord-258129-c38q6xxs 206 4 effects effect NNS cord-258129-c38q6xxs 206 5 of of IN cord-258129-c38q6xxs 206 6 these these DT cord-258129-c38q6xxs 206 7 mediators mediator NNS cord-258129-c38q6xxs 206 8 translate translate VBP cord-258129-c38q6xxs 206 9 from from IN cord-258129-c38q6xxs 206 10 pre pre JJ cord-258129-c38q6xxs 206 11 - - JJ cord-258129-c38q6xxs 206 12 clinical clinical JJ cord-258129-c38q6xxs 206 13 studies study NNS cord-258129-c38q6xxs 206 14 into into IN cord-258129-c38q6xxs 206 15 clinical clinical JJ cord-258129-c38q6xxs 206 16 trials trial NNS cord-258129-c38q6xxs 206 17 , , , cord-258129-c38q6xxs 206 18 they -PRON- PRP cord-258129-c38q6xxs 206 19 represent represent VBP cord-258129-c38q6xxs 206 20 promising promising JJ cord-258129-c38q6xxs 206 21 new new JJ cord-258129-c38q6xxs 206 22 strategies strategy NNS cord-258129-c38q6xxs 206 23 in in IN cord-258129-c38q6xxs 206 24 the the DT cord-258129-c38q6xxs 206 25 management management NN cord-258129-c38q6xxs 206 26 of of IN cord-258129-c38q6xxs 206 27 infectious infectious JJ cord-258129-c38q6xxs 206 28 disease disease NN cord-258129-c38q6xxs 206 29 . . . cord-258129-c38q6xxs 207 1 The the DT cord-258129-c38q6xxs 207 2 pro pro JJ cord-258129-c38q6xxs 207 3 - - JJ cord-258129-c38q6xxs 207 4 resolution resolution JJ cord-258129-c38q6xxs 207 5 , , , cord-258129-c38q6xxs 207 6 anti anti JJ cord-258129-c38q6xxs 207 7 - - JJ cord-258129-c38q6xxs 207 8 inflammatory inflammatory JJ cord-258129-c38q6xxs 207 9 and and CC cord-258129-c38q6xxs 207 10 antimicrobial antimicrobial NN cord-258129-c38q6xxs 207 11 - - HYPH cord-258129-c38q6xxs 207 12 enhancing enhance VBG cord-258129-c38q6xxs 207 13 effects effect NNS cord-258129-c38q6xxs 207 14 of of IN cord-258129-c38q6xxs 207 15 resolvins resolvin NNS cord-258129-c38q6xxs 207 16 , , , cord-258129-c38q6xxs 207 17 protectin protectin NNP cord-258129-c38q6xxs 207 18 and and CC cord-258129-c38q6xxs 207 19 possibly possibly RB cord-258129-c38q6xxs 207 20 lipoxins lipoxins NNP cord-258129-c38q6xxs 207 21 make make VBP cord-258129-c38q6xxs 207 22 these these DT cord-258129-c38q6xxs 207 23 appealing appeal VBG cord-258129-c38q6xxs 207 24 candidates candidate NNS cord-258129-c38q6xxs 207 25 for for IN cord-258129-c38q6xxs 207 26 further further JJ cord-258129-c38q6xxs 207 27 study study NN cord-258129-c38q6xxs 207 28 in in IN cord-258129-c38q6xxs 207 29 humans human NNS cord-258129-c38q6xxs 207 30 . . . cord-258129-c38q6xxs 208 1 From from IN cord-258129-c38q6xxs 208 2 a a DT cord-258129-c38q6xxs 208 3 therapeutic therapeutic JJ cord-258129-c38q6xxs 208 4 perspective perspective NN cord-258129-c38q6xxs 208 5 it -PRON- PRP cord-258129-c38q6xxs 208 6 is be VBZ cord-258129-c38q6xxs 208 7 important important JJ cord-258129-c38q6xxs 208 8 to to TO cord-258129-c38q6xxs 208 9 note note VB cord-258129-c38q6xxs 208 10 that that IN cord-258129-c38q6xxs 208 11 these these DT cord-258129-c38q6xxs 208 12 pro pro JJ cord-258129-c38q6xxs 208 13 - - JJ cord-258129-c38q6xxs 208 14 resolution resolution JJ cord-258129-c38q6xxs 208 15 mediators mediator NNS cord-258129-c38q6xxs 208 16 enjoy enjoy VBP cord-258129-c38q6xxs 208 17 a a DT cord-258129-c38q6xxs 208 18 substantial substantial JJ cord-258129-c38q6xxs 208 19 advantage advantage NN cord-258129-c38q6xxs 208 20 over over IN cord-258129-c38q6xxs 208 21 steroids steroid NNS cord-258129-c38q6xxs 208 22 for for IN cord-258129-c38q6xxs 208 23 use use NN cord-258129-c38q6xxs 208 24 in in IN cord-258129-c38q6xxs 208 25 the the DT cord-258129-c38q6xxs 208 26 treatment treatment NN cord-258129-c38q6xxs 208 27 of of IN cord-258129-c38q6xxs 208 28 infectious infectious JJ cord-258129-c38q6xxs 208 29 inflammation inflammation NN cord-258129-c38q6xxs 208 30 , , , cord-258129-c38q6xxs 208 31 or or CC cord-258129-c38q6xxs 208 32 other other JJ cord-258129-c38q6xxs 208 33 systemic systemic JJ cord-258129-c38q6xxs 208 34 inflammatory inflammatory JJ cord-258129-c38q6xxs 208 35 states state NNS cord-258129-c38q6xxs 208 36 , , , cord-258129-c38q6xxs 208 37 as as IN cord-258129-c38q6xxs 208 38 they -PRON- PRP cord-258129-c38q6xxs 208 39 are be VBP cord-258129-c38q6xxs 208 40 not not RB cord-258129-c38q6xxs 208 41 immunosuppressive immunosuppressive JJ cord-258129-c38q6xxs 208 42 agents agent NNS cord-258129-c38q6xxs 208 43 . . . cord-258129-c38q6xxs 208 44 ' ' '' cord-258129-c38q6xxs 209 1 Aspirin aspirin NN cord-258129-c38q6xxs 209 2 - - HYPH cord-258129-c38q6xxs 209 3 triggered trigger VBN cord-258129-c38q6xxs 209 4 ' ' '' cord-258129-c38q6xxs 209 5 lipoxins lipoxin NNS cord-258129-c38q6xxs 209 6 and and CC cord-258129-c38q6xxs 209 7 resolvins resolvins NNP cord-258129-c38q6xxs 209 8 share share VBP cord-258129-c38q6xxs 209 9 the the DT cord-258129-c38q6xxs 209 10 pro pro JJ cord-258129-c38q6xxs 209 11 - - JJ cord-258129-c38q6xxs 209 12 resolution resolution JJ cord-258129-c38q6xxs 209 13 effects effect NNS cord-258129-c38q6xxs 209 14 of of IN cord-258129-c38q6xxs 209 15 lipoxin lipoxin NNP cord-258129-c38q6xxs 209 16 A4 A4 NNP cord-258129-c38q6xxs 209 17 and and CC cord-258129-c38q6xxs 209 18 resolvin resolvin NNP cord-258129-c38q6xxs 209 19 D1 D1 NNP cord-258129-c38q6xxs 209 20 , , , cord-258129-c38q6xxs 209 21 respectively respectively RB cord-258129-c38q6xxs 209 22 , , , cord-258129-c38q6xxs 209 23 and and CC cord-258129-c38q6xxs 209 24 act act VB cord-258129-c38q6xxs 209 25 by by IN cord-258129-c38q6xxs 209 26 the the DT cord-258129-c38q6xxs 209 27 same same JJ cord-258129-c38q6xxs 209 28 intracellular intracellular JJ cord-258129-c38q6xxs 209 29 pathways pathway NNS cord-258129-c38q6xxs 209 30 . . . cord-258129-c38q6xxs 210 1 11 11 CD cord-258129-c38q6xxs 210 2 , , , cord-258129-c38q6xxs 210 3 14 14 CD cord-258129-c38q6xxs 210 4 , , , cord-258129-c38q6xxs 210 5 41 41 CD cord-258129-c38q6xxs 210 6 This this DT cord-258129-c38q6xxs 210 7 effect effect NN cord-258129-c38q6xxs 210 8 is be VBZ cord-258129-c38q6xxs 210 9 unique unique JJ cord-258129-c38q6xxs 210 10 to to TO cord-258129-c38q6xxs 210 11 aspirin aspirin VB cord-258129-c38q6xxs 210 12 , , , cord-258129-c38q6xxs 210 13 and and CC cord-258129-c38q6xxs 210 14 is be VBZ cord-258129-c38q6xxs 210 15 not not RB cord-258129-c38q6xxs 210 16 shared share VBN cord-258129-c38q6xxs 210 17 with with IN cord-258129-c38q6xxs 210 18 non non JJ cord-258129-c38q6xxs 210 19 - - JJ cord-258129-c38q6xxs 210 20 steroidal steroidal JJ cord-258129-c38q6xxs 210 21 anti anti JJ cord-258129-c38q6xxs 210 22 - - JJ cord-258129-c38q6xxs 210 23 inflammatory inflammatory JJ cord-258129-c38q6xxs 210 24 drugs drug NNS cord-258129-c38q6xxs 210 25 , , , cord-258129-c38q6xxs 210 26 which which WDT cord-258129-c38q6xxs 210 27 do do VBP cord-258129-c38q6xxs 210 28 not not RB cord-258129-c38q6xxs 210 29 trigger trigger VB cord-258129-c38q6xxs 210 30 the the DT cord-258129-c38q6xxs 210 31 biosynthesis biosynthesis NN cord-258129-c38q6xxs 210 32 of of IN cord-258129-c38q6xxs 210 33 these these DT cord-258129-c38q6xxs 210 34 mediators mediator NNS cord-258129-c38q6xxs 210 35 . . . cord-258129-c38q6xxs 211 1 Due due IN cord-258129-c38q6xxs 211 2 to to IN cord-258129-c38q6xxs 211 3 its -PRON- PRP$ cord-258129-c38q6xxs 211 4 ability ability NN cord-258129-c38q6xxs 211 5 to to TO cord-258129-c38q6xxs 211 6 trigger trigger VB cord-258129-c38q6xxs 211 7 the the DT cord-258129-c38q6xxs 211 8 production production NN cord-258129-c38q6xxs 211 9 of of IN cord-258129-c38q6xxs 211 10 these these DT cord-258129-c38q6xxs 211 11 pro pro JJ cord-258129-c38q6xxs 211 12 - - JJ cord-258129-c38q6xxs 211 13 resolution resolution JJ cord-258129-c38q6xxs 211 14 mediators mediator NNS cord-258129-c38q6xxs 211 15 there there RB cord-258129-c38q6xxs 211 16 may may MD cord-258129-c38q6xxs 211 17 be be VB cord-258129-c38q6xxs 211 18 a a DT cord-258129-c38q6xxs 211 19 new new JJ cord-258129-c38q6xxs 211 20 role role NN cord-258129-c38q6xxs 211 21 for for IN cord-258129-c38q6xxs 211 22 aspirin aspirin NN cord-258129-c38q6xxs 211 23 in in IN cord-258129-c38q6xxs 211 24 managing manage VBG cord-258129-c38q6xxs 211 25 the the DT cord-258129-c38q6xxs 211 26 inflammatory inflammatory JJ cord-258129-c38q6xxs 211 27 sequelae sequela NNS cord-258129-c38q6xxs 211 28 of of IN cord-258129-c38q6xxs 211 29 infectious infectious JJ cord-258129-c38q6xxs 211 30 disease disease NN cord-258129-c38q6xxs 211 31 . . . cord-258129-c38q6xxs 212 1 The the DT cord-258129-c38q6xxs 212 2 authors author NNS cord-258129-c38q6xxs 212 3 declare declare VBP cord-258129-c38q6xxs 212 4 that that IN cord-258129-c38q6xxs 212 5 they -PRON- PRP cord-258129-c38q6xxs 212 6 have have VBP cord-258129-c38q6xxs 212 7 no no DT cord-258129-c38q6xxs 212 8 competing compete VBG cord-258129-c38q6xxs 212 9 interests interest NNS cord-258129-c38q6xxs 212 10 . . . cord-258129-c38q6xxs 213 1 The the DT cord-258129-c38q6xxs 213 2 acute acute JJ cord-258129-c38q6xxs 213 3 respiratory respiratory JJ cord-258129-c38q6xxs 213 4 distress distress NN cord-258129-c38q6xxs 213 5 syndrome syndrome NN cord-258129-c38q6xxs 213 6 Molecular molecular JJ cord-258129-c38q6xxs 213 7 circuits circuit NNS cord-258129-c38q6xxs 213 8 of of IN cord-258129-c38q6xxs 213 9 resolution resolution NN cord-258129-c38q6xxs 213 10 : : : cord-258129-c38q6xxs 214 1 formation formation NN cord-258129-c38q6xxs 214 2 and and CC cord-258129-c38q6xxs 214 3 actions action NNS cord-258129-c38q6xxs 214 4 of of IN cord-258129-c38q6xxs 214 5 resolvins resolvins NNP cord-258129-c38q6xxs 214 6 and and CC cord-258129-c38q6xxs 214 7 protectins protectins NNP cord-258129-c38q6xxs 214 8 Resolvin Resolvin NNP cord-258129-c38q6xxs 214 9 E1 E1 NNP cord-258129-c38q6xxs 214 10 and and CC cord-258129-c38q6xxs 214 11 protectin protectin NNP cord-258129-c38q6xxs 214 12 D1 D1 NNP cord-258129-c38q6xxs 214 13 activate activate VBP cord-258129-c38q6xxs 214 14 inflammation inflammation NN cord-258129-c38q6xxs 214 15 - - HYPH cord-258129-c38q6xxs 214 16 resolution resolution NN cord-258129-c38q6xxs 214 17 programmes programme NNS cord-258129-c38q6xxs 214 18 Lipoxin Lipoxin NNP cord-258129-c38q6xxs 214 19 biosynthesis biosynthesis NN cord-258129-c38q6xxs 214 20 and and CC cord-258129-c38q6xxs 214 21 its -PRON- PRP$ cord-258129-c38q6xxs 214 22 impact impact NN cord-258129-c38q6xxs 214 23 in in IN cord-258129-c38q6xxs 214 24 inflammatory inflammatory JJ cord-258129-c38q6xxs 214 25 and and CC cord-258129-c38q6xxs 214 26 vascular vascular JJ cord-258129-c38q6xxs 214 27 events event NNS cord-258129-c38q6xxs 215 1 Lipoxins Lipoxins NNP cord-258129-c38q6xxs 215 2 and and CC cord-258129-c38q6xxs 215 3 aspirin aspirin NN cord-258129-c38q6xxs 215 4 - - HYPH cord-258129-c38q6xxs 215 5 triggered trigger VBN cord-258129-c38q6xxs 215 6 15-epi 15-epi CD cord-258129-c38q6xxs 215 7 - - HYPH cord-258129-c38q6xxs 215 8 lipoxins lipoxin NNS cord-258129-c38q6xxs 215 9 are be VBP cord-258129-c38q6xxs 215 10 the the DT cord-258129-c38q6xxs 215 11 first first JJ cord-258129-c38q6xxs 215 12 lipid lipid NN cord-258129-c38q6xxs 215 13 mediators mediator NNS cord-258129-c38q6xxs 215 14 of of IN cord-258129-c38q6xxs 215 15 endogenous endogenous JJ cord-258129-c38q6xxs 215 16 anti anti JJ cord-258129-c38q6xxs 215 17 - - JJ cord-258129-c38q6xxs 215 18 inflammation inflammation JJ cord-258129-c38q6xxs 215 19 and and CC cord-258129-c38q6xxs 215 20 resolution resolution NN cord-258129-c38q6xxs 215 21 Resolvins Resolvins NNP cord-258129-c38q6xxs 215 22 : : : cord-258129-c38q6xxs 215 23 a a DT cord-258129-c38q6xxs 215 24 family family NN cord-258129-c38q6xxs 215 25 of of IN cord-258129-c38q6xxs 215 26 bioactive bioactive JJ cord-258129-c38q6xxs 215 27 products product NNS cord-258129-c38q6xxs 215 28 of of IN cord-258129-c38q6xxs 215 29 omega-3 omega-3 NN cord-258129-c38q6xxs 215 30 fatty fatty JJ cord-258129-c38q6xxs 215 31 acid acid NN cord-258129-c38q6xxs 215 32 transformation transformation NN cord-258129-c38q6xxs 215 33 circuits circuit NNS cord-258129-c38q6xxs 215 34 initiated initiate VBN cord-258129-c38q6xxs 215 35 by by IN cord-258129-c38q6xxs 215 36 aspirin aspirin NN cord-258129-c38q6xxs 215 37 treatment treatment NN cord-258129-c38q6xxs 215 38 that that WDT cord-258129-c38q6xxs 215 39 counter counter VBP cord-258129-c38q6xxs 215 40 proinflammation proinflammation NN cord-258129-c38q6xxs 215 41 signals signal VBZ cord-258129-c38q6xxs 215 42 Anti anti JJ cord-258129-c38q6xxs 215 43 - - JJ cord-258129-c38q6xxs 215 44 inflammatory inflammatory JJ cord-258129-c38q6xxs 215 45 actions action NNS cord-258129-c38q6xxs 215 46 of of IN cord-258129-c38q6xxs 215 47 neuroprotectin neuroprotectin NNP cord-258129-c38q6xxs 215 48 D1 D1 NNP cord-258129-c38q6xxs 215 49 / / SYM cord-258129-c38q6xxs 215 50 protectin protectin NNP cord-258129-c38q6xxs 215 51 D1 D1 NNP cord-258129-c38q6xxs 215 52 and and CC cord-258129-c38q6xxs 215 53 its -PRON- PRP$ cord-258129-c38q6xxs 215 54 natural natural JJ cord-258129-c38q6xxs 215 55 stereoisomers stereoisomer NNS cord-258129-c38q6xxs 215 56 : : : cord-258129-c38q6xxs 215 57 assignments assignment NNS cord-258129-c38q6xxs 215 58 of of IN cord-258129-c38q6xxs 215 59 dihydroxy dihydroxy NN cord-258129-c38q6xxs 215 60 - - HYPH cord-258129-c38q6xxs 215 61 containing contain VBG cord-258129-c38q6xxs 215 62 docosatrienes docosatrienes NNP cord-258129-c38q6xxs 215 63 Multi multi JJ cord-258129-c38q6xxs 215 64 - - JJ cord-258129-c38q6xxs 215 65 pronged pronged JJ cord-258129-c38q6xxs 215 66 inhibition inhibition NN cord-258129-c38q6xxs 215 67 of of IN cord-258129-c38q6xxs 215 68 airway airway JJ cord-258129-c38q6xxs 215 69 hyper hyper NN cord-258129-c38q6xxs 215 70 - - NN cord-258129-c38q6xxs 215 71 responsiveness responsiveness NN cord-258129-c38q6xxs 215 72 and and CC cord-258129-c38q6xxs 215 73 inflammation inflammation NN cord-258129-c38q6xxs 215 74 by by IN cord-258129-c38q6xxs 215 75 lipoxin lipoxin NNP cord-258129-c38q6xxs 216 1 A(4 a(4 LS cord-258129-c38q6xxs 216 2 ) ) -RRB- cord-258129-c38q6xxs 217 1 Resolvin Resolvin NNP cord-258129-c38q6xxs 217 2 E1 E1 NNP cord-258129-c38q6xxs 217 3 regulates regulate VBZ cord-258129-c38q6xxs 217 4 interleukin interleukin NN cord-258129-c38q6xxs 217 5 23 23 CD cord-258129-c38q6xxs 217 6 , , , cord-258129-c38q6xxs 217 7 interferon interferon NN cord-258129-c38q6xxs 217 8 - - HYPH cord-258129-c38q6xxs 217 9 c c NNP cord-258129-c38q6xxs 217 10 and and CC cord-258129-c38q6xxs 217 11 lipoxin lipoxin NNP cord-258129-c38q6xxs 217 12 A4 A4 NNP cord-258129-c38q6xxs 217 13 to to TO cord-258129-c38q6xxs 217 14 promote promote VB cord-258129-c38q6xxs 217 15 the the DT cord-258129-c38q6xxs 217 16 resolution resolution NN cord-258129-c38q6xxs 217 17 of of IN cord-258129-c38q6xxs 217 18 allergic allergic JJ cord-258129-c38q6xxs 217 19 airway airway NN cord-258129-c38q6xxs 217 20 inflammation inflammation NN cord-258129-c38q6xxs 217 21 Protectin Protectin NNP cord-258129-c38q6xxs 217 22 D1 d1 NN cord-258129-c38q6xxs 217 23 is be VBZ cord-258129-c38q6xxs 217 24 generated generate VBN cord-258129-c38q6xxs 217 25 in in IN cord-258129-c38q6xxs 217 26 asthma asthma NN cord-258129-c38q6xxs 217 27 and and CC cord-258129-c38q6xxs 217 28 dampens dampen VBZ cord-258129-c38q6xxs 217 29 airway airway JJ cord-258129-c38q6xxs 217 30 inflammation inflammation NN cord-258129-c38q6xxs 217 31 and and CC cord-258129-c38q6xxs 217 32 hyperresponsiveness hyperresponsiveness NNP cord-258129-c38q6xxs 217 33 Resolvin Resolvin NNP cord-258129-c38q6xxs 217 34 D1 D1 NNP cord-258129-c38q6xxs 217 35 and and CC cord-258129-c38q6xxs 217 36 aspirin aspirin NN cord-258129-c38q6xxs 217 37 - - HYPH cord-258129-c38q6xxs 217 38 triggered trigger VBN cord-258129-c38q6xxs 217 39 resolvin resolvin NNP cord-258129-c38q6xxs 217 40 D1 D1 NNP cord-258129-c38q6xxs 217 41 promote promote VB cord-258129-c38q6xxs 217 42 resolution resolution NN cord-258129-c38q6xxs 217 43 of of IN cord-258129-c38q6xxs 217 44 allergic allergic JJ cord-258129-c38q6xxs 217 45 airways airway NNS cord-258129-c38q6xxs 217 46 responses response NNS cord-258129-c38q6xxs 217 47 Lethal lethal JJ cord-258129-c38q6xxs 217 48 dissemination dissemination NN cord-258129-c38q6xxs 217 49 of of IN cord-258129-c38q6xxs 217 50 H5N1 H5N1 NNP cord-258129-c38q6xxs 217 51 influenza influenza NN cord-258129-c38q6xxs 217 52 virus virus NN cord-258129-c38q6xxs 217 53 is be VBZ cord-258129-c38q6xxs 217 54 associated associate VBN cord-258129-c38q6xxs 217 55 with with IN cord-258129-c38q6xxs 217 56 dysregulation dysregulation NN cord-258129-c38q6xxs 217 57 of of IN cord-258129-c38q6xxs 217 58 inflammation inflammation NN cord-258129-c38q6xxs 217 59 and and CC cord-258129-c38q6xxs 217 60 lipoxin lipoxin NNP cord-258129-c38q6xxs 217 61 signaling signal VBG cord-258129-c38q6xxs 217 62 in in IN cord-258129-c38q6xxs 217 63 a a DT cord-258129-c38q6xxs 217 64 mouse mouse NN cord-258129-c38q6xxs 217 65 model model NN cord-258129-c38q6xxs 217 66 of of IN cord-258129-c38q6xxs 217 67 infection infection NN cord-258129-c38q6xxs 217 68 Emergence emergence NN cord-258129-c38q6xxs 217 69 and and CC cord-258129-c38q6xxs 217 70 pandemic pandemic NN cord-258129-c38q6xxs 217 71 potential potential NN cord-258129-c38q6xxs 217 72 of of IN cord-258129-c38q6xxs 217 73 swine swine NN cord-258129-c38q6xxs 217 74 - - HYPH cord-258129-c38q6xxs 217 75 origin origin NN cord-258129-c38q6xxs 217 76 H1N1 H1N1 NNP cord-258129-c38q6xxs 217 77 influenza influenza NN cord-258129-c38q6xxs 217 78 virus virus NN cord-258129-c38q6xxs 217 79 Antiinflammatory antiinflammatory JJ cord-258129-c38q6xxs 217 80 actions action NNS cord-258129-c38q6xxs 217 81 of of IN cord-258129-c38q6xxs 217 82 lipoxin lipoxin NNP cord-258129-c38q6xxs 217 83 A4 A4 NNP cord-258129-c38q6xxs 217 84 and and CC cord-258129-c38q6xxs 217 85 aspirin aspirin NN cord-258129-c38q6xxs 217 86 - - HYPH cord-258129-c38q6xxs 217 87 triggered trigger VBN cord-258129-c38q6xxs 217 88 lipoxin lipoxin NN cord-258129-c38q6xxs 217 89 are be VBP cord-258129-c38q6xxs 217 90 SOCS-2 socs-2 JJ cord-258129-c38q6xxs 217 91 dependent dependent JJ cord-258129-c38q6xxs 217 92 Role role NN cord-258129-c38q6xxs 217 93 of of IN cord-258129-c38q6xxs 217 94 the the DT cord-258129-c38q6xxs 217 95 lipoxygenase lipoxygenase NN cord-258129-c38q6xxs 217 96 pathway pathway NN cord-258129-c38q6xxs 217 97 in in IN cord-258129-c38q6xxs 217 98 RSV RSV NNP cord-258129-c38q6xxs 217 99 - - HYPH cord-258129-c38q6xxs 217 100 induced induce VBN cord-258129-c38q6xxs 217 101 alternatively alternatively RB cord-258129-c38q6xxs 217 102 activated activate VBD cord-258129-c38q6xxs 217 103 macrophages macrophage NNS cord-258129-c38q6xxs 217 104 leading lead VBG cord-258129-c38q6xxs 217 105 to to IN cord-258129-c38q6xxs 217 106 resolution resolution NN cord-258129-c38q6xxs 217 107 of of IN cord-258129-c38q6xxs 217 108 lung lung NN cord-258129-c38q6xxs 217 109 pathology pathology NN cord-258129-c38q6xxs 217 110 Control Control NNP cord-258129-c38q6xxs 217 111 of of IN cord-258129-c38q6xxs 217 112 RSV RSV NNP cord-258129-c38q6xxs 217 113 - - HYPH cord-258129-c38q6xxs 217 114 induced induce VBN cord-258129-c38q6xxs 217 115 lung lung NN cord-258129-c38q6xxs 217 116 injury injury NN cord-258129-c38q6xxs 217 117 by by IN cord-258129-c38q6xxs 217 118 alternatively alternatively RB cord-258129-c38q6xxs 217 119 activated activate VBN cord-258129-c38q6xxs 217 120 macrophages macrophage NNS cord-258129-c38q6xxs 218 1 is be VBZ cord-258129-c38q6xxs 218 2 IL-4Ra- IL-4Ra- NNP cord-258129-c38q6xxs 218 3 , , , cord-258129-c38q6xxs 219 1 TLR4- tlr4- NN cord-258129-c38q6xxs 219 2 , , , cord-258129-c38q6xxs 219 3 and and CC cord-258129-c38q6xxs 219 4 IFN IFN NNP cord-258129-c38q6xxs 219 5 - - HYPH cord-258129-c38q6xxs 219 6 b b NN cord-258129-c38q6xxs 219 7 - - HYPH cord-258129-c38q6xxs 219 8 dependent dependent JJ cord-258129-c38q6xxs 219 9 Elevated elevated JJ cord-258129-c38q6xxs 219 10 formation formation NN cord-258129-c38q6xxs 219 11 of of IN cord-258129-c38q6xxs 219 12 lipoxins lipoxin NNS cord-258129-c38q6xxs 219 13 in in IN cord-258129-c38q6xxs 219 14 viral viral JJ cord-258129-c38q6xxs 219 15 antibody antibody NN cord-258129-c38q6xxs 219 16 - - HYPH cord-258129-c38q6xxs 219 17 positive positive JJ cord-258129-c38q6xxs 219 18 rat rat NN cord-258129-c38q6xxs 219 19 alveolar alveolar NN cord-258129-c38q6xxs 219 20 macrophages macrophage NNS cord-258129-c38q6xxs 219 21 Cytokines cytokine NNS cord-258129-c38q6xxs 219 22 and and CC cord-258129-c38q6xxs 219 23 arachidonic arachidonic JJ cord-258129-c38q6xxs 219 24 metabolites metabolite NNS cord-258129-c38q6xxs 219 25 produced produce VBN cord-258129-c38q6xxs 219 26 during during IN cord-258129-c38q6xxs 219 27 human human JJ cord-258129-c38q6xxs 219 28 immunodeficiency immunodeficiency NN cord-258129-c38q6xxs 219 29 virus virus NN cord-258129-c38q6xxs 219 30 ( ( -LRB- cord-258129-c38q6xxs 219 31 HIV)-infected hiv)-infected JJ cord-258129-c38q6xxs 219 32 macrophage macrophage NN cord-258129-c38q6xxs 219 33 - - HYPH cord-258129-c38q6xxs 219 34 astroglia astroglia JJ cord-258129-c38q6xxs 219 35 interactions interaction NNS cord-258129-c38q6xxs 219 36 : : : cord-258129-c38q6xxs 219 37 implications implication NNS cord-258129-c38q6xxs 219 38 for for IN cord-258129-c38q6xxs 219 39 the the DT cord-258129-c38q6xxs 219 40 neuropathogenesis neuropathogenesis NN cord-258129-c38q6xxs 219 41 of of IN cord-258129-c38q6xxs 219 42 HIV HIV NNP cord-258129-c38q6xxs 219 43 disease disease NN cord-258129-c38q6xxs 219 44 Host Host NNP cord-258129-c38q6xxs 219 45 control control NN cord-258129-c38q6xxs 219 46 of of IN cord-258129-c38q6xxs 219 47 Mycobacterium Mycobacterium NNP cord-258129-c38q6xxs 219 48 tuberculosis tuberculosis NN cord-258129-c38q6xxs 219 49 is be VBZ cord-258129-c38q6xxs 219 50 regulated regulate VBN cord-258129-c38q6xxs 219 51 by by IN cord-258129-c38q6xxs 219 52 5-lipoxygenase 5-lipoxygenase CD cord-258129-c38q6xxs 219 53 - - HYPH cord-258129-c38q6xxs 219 54 dependent dependent JJ cord-258129-c38q6xxs 219 55 lipoxin lipoxin NNP cord-258129-c38q6xxs 219 56 production production NN cord-258129-c38q6xxs 219 57 Identification identification NN cord-258129-c38q6xxs 219 58 of of IN cord-258129-c38q6xxs 219 59 nitric nitric JJ cord-258129-c38q6xxs 219 60 oxide oxide NN cord-258129-c38q6xxs 219 61 synthase synthase NN cord-258129-c38q6xxs 219 62 as as IN cord-258129-c38q6xxs 219 63 a a DT cord-258129-c38q6xxs 219 64 protective protective JJ cord-258129-c38q6xxs 219 65 locus locus NN cord-258129-c38q6xxs 219 66 against against IN cord-258129-c38q6xxs 219 67 tuberculosis tuberculosis NN cord-258129-c38q6xxs 219 68 Parasite parasite NN cord-258129-c38q6xxs 219 69 - - HYPH cord-258129-c38q6xxs 219 70 induced induce VBN cord-258129-c38q6xxs 219 71 lipoxin lipoxin NNP cord-258129-c38q6xxs 219 72 A4 A4 NNP cord-258129-c38q6xxs 219 73 is be VBZ cord-258129-c38q6xxs 219 74 an an DT cord-258129-c38q6xxs 219 75 endogenous endogenous JJ cord-258129-c38q6xxs 219 76 regulator regulator NN cord-258129-c38q6xxs 219 77 of of IN cord-258129-c38q6xxs 219 78 IL-12 IL-12 NNP cord-258129-c38q6xxs 219 79 production production NN cord-258129-c38q6xxs 219 80 and and CC cord-258129-c38q6xxs 219 81 immunopathology immunopathology NN cord-258129-c38q6xxs 219 82 in in IN cord-258129-c38q6xxs 219 83 Toxoplasma toxoplasma JJ cord-258129-c38q6xxs 219 84 gondii gondii NN cord-258129-c38q6xxs 219 85 infection infection NN cord-258129-c38q6xxs 219 86 Lipoxin Lipoxin NNP cord-258129-c38q6xxs 219 87 - - HYPH cord-258129-c38q6xxs 219 88 mediated mediate VBN cord-258129-c38q6xxs 219 89 inhibition inhibition NN cord-258129-c38q6xxs 219 90 of of IN cord-258129-c38q6xxs 219 91 IL-12 IL-12 NNP cord-258129-c38q6xxs 219 92 production production NN cord-258129-c38q6xxs 219 93 by by IN cord-258129-c38q6xxs 219 94 DCs DCs NNP cord-258129-c38q6xxs 219 95 : : : cord-258129-c38q6xxs 219 96 a a DT cord-258129-c38q6xxs 219 97 mechanism mechanism NN cord-258129-c38q6xxs 219 98 for for IN cord-258129-c38q6xxs 219 99 regulation regulation NN cord-258129-c38q6xxs 219 100 of of IN cord-258129-c38q6xxs 219 101 microbial microbial JJ cord-258129-c38q6xxs 219 102 immunity immunity NN cord-258129-c38q6xxs 219 103 Protective protective JJ cord-258129-c38q6xxs 219 104 role role NN cord-258129-c38q6xxs 219 105 of of IN cord-258129-c38q6xxs 219 106 acetylsalicylic acetylsalicylic JJ cord-258129-c38q6xxs 219 107 acid acid NN cord-258129-c38q6xxs 219 108 in in IN cord-258129-c38q6xxs 219 109 experimental experimental JJ cord-258129-c38q6xxs 219 110 Trypanosoma Trypanosoma NNP cord-258129-c38q6xxs 219 111 cruzi cruzi NNP cord-258129-c38q6xxs 219 112 infection infection NN cord-258129-c38q6xxs 219 113 : : : cord-258129-c38q6xxs 219 114 evidence evidence NN cord-258129-c38q6xxs 219 115 of of IN cord-258129-c38q6xxs 219 116 a a DT cord-258129-c38q6xxs 219 117 15-epi 15-epi CD cord-258129-c38q6xxs 219 118 - - HYPH cord-258129-c38q6xxs 219 119 lipoxin lipoxin NN cord-258129-c38q6xxs 219 120 A₄-mediated a₄-mediate VBN cord-258129-c38q6xxs 219 121 effect effect NN cord-258129-c38q6xxs 219 122 Lipoxin Lipoxin NNP cord-258129-c38q6xxs 219 123 A₄ A₄ NNP cord-258129-c38q6xxs 219 124 and and CC cord-258129-c38q6xxs 219 125 15-epi 15-epi CD cord-258129-c38q6xxs 219 126 - - HYPH cord-258129-c38q6xxs 219 127 lipoxin lipoxin NNP cord-258129-c38q6xxs 219 128 A₄ A₄ NNP cord-258129-c38q6xxs 219 129 protect protect NN cord-258129-c38q6xxs 219 130 against against IN cord-258129-c38q6xxs 219 131 experimental experimental JJ cord-258129-c38q6xxs 219 132 cerebral cerebral JJ cord-258129-c38q6xxs 219 133 malaria malaria NN cord-258129-c38q6xxs 219 134 by by IN cord-258129-c38q6xxs 219 135 inhibiting inhibit VBG cord-258129-c38q6xxs 219 136 IL-12/ IL-12/ NNP cord-258129-c38q6xxs 219 137 IFN IFN NNP cord-258129-c38q6xxs 219 138 - - HYPH cord-258129-c38q6xxs 219 139 c c NNP cord-258129-c38q6xxs 219 140 in in IN cord-258129-c38q6xxs 219 141 the the DT cord-258129-c38q6xxs 219 142 brain brain NN cord-258129-c38q6xxs 220 1 Reduced reduce VBN cord-258129-c38q6xxs 220 2 inflammation inflammation NN cord-258129-c38q6xxs 220 3 and and CC cord-258129-c38q6xxs 220 4 tissue tissue NN cord-258129-c38q6xxs 220 5 damage damage NN cord-258129-c38q6xxs 220 6 in in IN cord-258129-c38q6xxs 220 7 transgenic transgenic JJ cord-258129-c38q6xxs 220 8 rabbits rabbit NNS cord-258129-c38q6xxs 220 9 overexpressing overexpresse VBG cord-258129-c38q6xxs 220 10 15-lipoxygenase 15-lipoxygenase CD cord-258129-c38q6xxs 220 11 and and CC cord-258129-c38q6xxs 220 12 endogenous endogenous JJ cord-258129-c38q6xxs 220 13 anti anti JJ cord-258129-c38q6xxs 220 14 - - JJ cord-258129-c38q6xxs 220 15 inflammatory inflammatory JJ cord-258129-c38q6xxs 220 16 lipid lipid NN cord-258129-c38q6xxs 220 17 mediators mediator NNS cord-258129-c38q6xxs 220 18 Resolution resolution NN cord-258129-c38q6xxs 220 19 of of IN cord-258129-c38q6xxs 220 20 inflammation inflammation NN cord-258129-c38q6xxs 220 21 : : : cord-258129-c38q6xxs 220 22 a a DT cord-258129-c38q6xxs 220 23 new new JJ cord-258129-c38q6xxs 220 24 paradigm paradigm NN cord-258129-c38q6xxs 220 25 for for IN cord-258129-c38q6xxs 220 26 the the DT cord-258129-c38q6xxs 220 27 pathogenesis pathogenesis NN cord-258129-c38q6xxs 220 28 of of IN cord-258129-c38q6xxs 220 29 periodontal periodontal JJ cord-258129-c38q6xxs 220 30 diseases disease NNS cord-258129-c38q6xxs 220 31 Lipid Lipid NNP cord-258129-c38q6xxs 220 32 mediator mediator NN cord-258129-c38q6xxs 220 33 - - HYPH cord-258129-c38q6xxs 220 34 induced induce VBN cord-258129-c38q6xxs 220 35 expression expression NN cord-258129-c38q6xxs 220 36 of of IN cord-258129-c38q6xxs 220 37 bactericidal bactericidal JJ cord-258129-c38q6xxs 220 38 / / SYM cord-258129-c38q6xxs 220 39 permeability permeability NN cord-258129-c38q6xxs 220 40 - - HYPH cord-258129-c38q6xxs 220 41 increasing increase VBG cord-258129-c38q6xxs 220 42 protein protein NN cord-258129-c38q6xxs 220 43 ( ( -LRB- cord-258129-c38q6xxs 220 44 BPI BPI NNP cord-258129-c38q6xxs 220 45 ) ) -RRB- cord-258129-c38q6xxs 220 46 in in IN cord-258129-c38q6xxs 220 47 human human JJ cord-258129-c38q6xxs 220 48 mucosal mucosal NN cord-258129-c38q6xxs 220 49 epithelia epithelium NNS cord-258129-c38q6xxs 220 50 Lipoxin Lipoxin NNP cord-258129-c38q6xxs 220 51 a4 a4 NNP cord-258129-c38q6xxs 220 52 analogs analog NNS cord-258129-c38q6xxs 221 1 attenuate attenuate VB cord-258129-c38q6xxs 221 2 induction induction NN cord-258129-c38q6xxs 221 3 of of IN cord-258129-c38q6xxs 221 4 intestinal intestinal JJ cord-258129-c38q6xxs 221 5 epithelial epithelial JJ cord-258129-c38q6xxs 221 6 proinflammatory proinflammatory JJ cord-258129-c38q6xxs 221 7 gene gene NN cord-258129-c38q6xxs 221 8 expression expression NN cord-258129-c38q6xxs 221 9 and and CC cord-258129-c38q6xxs 221 10 reduce reduce VB cord-258129-c38q6xxs 221 11 the the DT cord-258129-c38q6xxs 221 12 severity severity NN cord-258129-c38q6xxs 221 13 of of IN cord-258129-c38q6xxs 221 14 dextran dextran NN cord-258129-c38q6xxs 221 15 sodium sodium NN cord-258129-c38q6xxs 221 16 sulfate sulfate NN cord-258129-c38q6xxs 221 17 - - HYPH cord-258129-c38q6xxs 221 18 induced induce VBN cord-258129-c38q6xxs 221 19 colitis colitis NN cord-258129-c38q6xxs 221 20 Resolvin Resolvin NNP cord-258129-c38q6xxs 221 21 D2 D2 NNP cord-258129-c38q6xxs 221 22 is be VBZ cord-258129-c38q6xxs 221 23 a a DT cord-258129-c38q6xxs 221 24 potent potent JJ cord-258129-c38q6xxs 221 25 regulator regulator NN cord-258129-c38q6xxs 221 26 of of IN cord-258129-c38q6xxs 221 27 leukocytes leukocyte NNS cord-258129-c38q6xxs 221 28 and and CC cord-258129-c38q6xxs 221 29 controls control VBZ cord-258129-c38q6xxs 221 30 microbial microbial JJ cord-258129-c38q6xxs 221 31 sepsis sepsis NN cord-258129-c38q6xxs 221 32 Infection infection NN cord-258129-c38q6xxs 221 33 regulates regulate VBZ cord-258129-c38q6xxs 221 34 pro pro JJ cord-258129-c38q6xxs 221 35 - - JJ cord-258129-c38q6xxs 221 36 resolving resolve VBG cord-258129-c38q6xxs 221 37 mediators mediator NNS cord-258129-c38q6xxs 221 38 that that WDT cord-258129-c38q6xxs 221 39 lower lower VBP cord-258129-c38q6xxs 221 40 antibiotic antibiotic JJ cord-258129-c38q6xxs 221 41 requirements requirement NNS cord-258129-c38q6xxs 221 42 Resolvin Resolvin NNP cord-258129-c38q6xxs 221 43 D2 d2 NN cord-258129-c38q6xxs 221 44 restores restore VBZ cord-258129-c38q6xxs 221 45 neutrophil neutrophil NN cord-258129-c38q6xxs 221 46 directionality directionality NN cord-258129-c38q6xxs 221 47 and and CC cord-258129-c38q6xxs 221 48 improves improve VBZ cord-258129-c38q6xxs 221 49 survival survival NN cord-258129-c38q6xxs 221 50 after after IN cord-258129-c38q6xxs 221 51 burns burn NNS cord-258129-c38q6xxs 222 1 The the DT cord-258129-c38q6xxs 222 2 anti anti JJ cord-258129-c38q6xxs 222 3 - - JJ cord-258129-c38q6xxs 222 4 inflammatory inflammatory JJ cord-258129-c38q6xxs 222 5 and and CC cord-258129-c38q6xxs 222 6 proresolving proresolve VBG cord-258129-c38q6xxs 222 7 mediator mediator NN cord-258129-c38q6xxs 222 8 resolvin resolvin NNP cord-258129-c38q6xxs 222 9 E1 E1 NNP cord-258129-c38q6xxs 222 10 protects protect VBZ cord-258129-c38q6xxs 222 11 mice mouse NNS cord-258129-c38q6xxs 222 12 from from IN cord-258129-c38q6xxs 222 13 bacterial bacterial JJ cord-258129-c38q6xxs 222 14 pneumonia pneumonia NN cord-258129-c38q6xxs 222 15 and and CC cord-258129-c38q6xxs 223 1 acute acute JJ cord-258129-c38q6xxs 223 2 lung lung NN cord-258129-c38q6xxs 223 3 injury injury NN cord-258129-c38q6xxs 223 4 Neutrophil Neutrophil NNP cord-258129-c38q6xxs 223 5 apoptosis apoptosis NN cord-258129-c38q6xxs 223 6 : : : cord-258129-c38q6xxs 223 7 a a DT cord-258129-c38q6xxs 223 8 marker marker NN cord-258129-c38q6xxs 223 9 of of IN cord-258129-c38q6xxs 223 10 disease disease NN cord-258129-c38q6xxs 223 11 severity severity NN cord-258129-c38q6xxs 223 12 in in IN cord-258129-c38q6xxs 223 13 sepsis sepsis NN cord-258129-c38q6xxs 223 14 and and CC cord-258129-c38q6xxs 224 1 sepsis sepsis NN cord-258129-c38q6xxs 224 2 - - HYPH cord-258129-c38q6xxs 224 3 induced induce VBN cord-258129-c38q6xxs 224 4 acute acute JJ cord-258129-c38q6xxs 224 5 respiratory respiratory JJ cord-258129-c38q6xxs 224 6 distress distress NN cord-258129-c38q6xxs 224 7 syndrome syndrome NN cord-258129-c38q6xxs 224 8 Resolvin Resolvin NNP cord-258129-c38q6xxs 224 9 E1 E1 NNP cord-258129-c38q6xxs 224 10 promotes promote VBZ cord-258129-c38q6xxs 224 11 phagocytosis phagocytosis NN cord-258129-c38q6xxs 224 12 - - HYPH cord-258129-c38q6xxs 224 13 induced induce VBN cord-258129-c38q6xxs 224 14 neutrophil neutrophil NN cord-258129-c38q6xxs 224 15 apoptosis apoptosis NN cord-258129-c38q6xxs 224 16 and and CC cord-258129-c38q6xxs 224 17 accelerates accelerate VBZ cord-258129-c38q6xxs 224 18 resolution resolution NN cord-258129-c38q6xxs 224 19 of of IN cord-258129-c38q6xxs 224 20 pulmonary pulmonary JJ cord-258129-c38q6xxs 224 21 inflammation inflammation NN cord-258129-c38q6xxs 225 1 15-epi 15-epi CD cord-258129-c38q6xxs 225 2 - - HYPH cord-258129-c38q6xxs 225 3 lipoxin lipoxin NNP cord-258129-c38q6xxs 225 4 A4 A4 NNP cord-258129-c38q6xxs 225 5 inhibits inhibit VBZ cord-258129-c38q6xxs 225 6 myeloperoxidase myeloperoxidase NN cord-258129-c38q6xxs 225 7 signaling signaling NN cord-258129-c38q6xxs 225 8 and and CC cord-258129-c38q6xxs 225 9 enhances enhance VBZ cord-258129-c38q6xxs 225 10 resolution resolution NN cord-258129-c38q6xxs 225 11 of of IN cord-258129-c38q6xxs 225 12 acute acute JJ cord-258129-c38q6xxs 225 13 lung lung NN cord-258129-c38q6xxs 225 14 injury injury NN cord-258129-c38q6xxs 225 15 Controlling control VBG cord-258129-c38q6xxs 225 16 herpes herpes NNP cord-258129-c38q6xxs 225 17 simplex simplex NNP cord-258129-c38q6xxs 225 18 virus virus NN cord-258129-c38q6xxs 225 19 - - HYPH cord-258129-c38q6xxs 225 20 induced induce VBN cord-258129-c38q6xxs 225 21 ocular ocular JJ cord-258129-c38q6xxs 225 22 inflammatory inflammatory JJ cord-258129-c38q6xxs 225 23 lesions lesion NNS cord-258129-c38q6xxs 225 24 with with IN cord-258129-c38q6xxs 225 25 the the DT cord-258129-c38q6xxs 225 26 lipid lipid NN cord-258129-c38q6xxs 225 27 - - HYPH cord-258129-c38q6xxs 225 28 derived derive VBN cord-258129-c38q6xxs 225 29 mediator mediator NN cord-258129-c38q6xxs 225 30 resolvin resolvin NNP cord-258129-c38q6xxs 225 31 E1 E1 NNP cord-258129-c38q6xxs 226 1 The the DT cord-258129-c38q6xxs 226 2 lipid lipid NN cord-258129-c38q6xxs 226 3 mediator mediator NN cord-258129-c38q6xxs 226 4 protectin protectin NNP cord-258129-c38q6xxs 226 5 D1 D1 NNP cord-258129-c38q6xxs 226 6 inhibits inhibit VBZ cord-258129-c38q6xxs 226 7 influenza influenza NN cord-258129-c38q6xxs 226 8 virus virus NN cord-258129-c38q6xxs 226 9 replication replication NN cord-258129-c38q6xxs 226 10 and and CC cord-258129-c38q6xxs 226 11 improves improve VBZ cord-258129-c38q6xxs 226 12 severe severe JJ cord-258129-c38q6xxs 226 13 influenza influenza NN cord-258129-c38q6xxs 226 14 Resolvins Resolvins NNP cord-258129-c38q6xxs 226 15 : : : cord-258129-c38q6xxs 226 16 natural natural JJ cord-258129-c38q6xxs 226 17 agonists agonist NNS cord-258129-c38q6xxs 226 18 for for IN cord-258129-c38q6xxs 226 19 resolution resolution NN cord-258129-c38q6xxs 226 20 of of IN cord-258129-c38q6xxs 226 21 pulmonary pulmonary JJ cord-258129-c38q6xxs 226 22 inflammation inflammation NN cord-258129-c38q6xxs 226 23 Severe severe JJ cord-258129-c38q6xxs 226 24 respiratory respiratory JJ cord-258129-c38q6xxs 226 25 syncytial syncytial JJ cord-258129-c38q6xxs 226 26 virus virus NN cord-258129-c38q6xxs 226 27 bronchiolitis bronchiolitis NN cord-258129-c38q6xxs 226 28 in in IN cord-258129-c38q6xxs 226 29 infancy infancy NN cord-258129-c38q6xxs 226 30 and and CC cord-258129-c38q6xxs 226 31 asthma asthma NN cord-258129-c38q6xxs 226 32 and and CC cord-258129-c38q6xxs 226 33 allergy allergy NN cord-258129-c38q6xxs 226 34 at at IN cord-258129-c38q6xxs 226 35 age age NN cord-258129-c38q6xxs 226 36 13 13 CD cord-258129-c38q6xxs 226 37 Respiratory respiratory JJ cord-258129-c38q6xxs 226 38 syncytial syncytial JJ cord-258129-c38q6xxs 226 39 virus virus NN cord-258129-c38q6xxs 226 40 in in IN cord-258129-c38q6xxs 226 41 early early JJ cord-258129-c38q6xxs 226 42 life life NN cord-258129-c38q6xxs 226 43 and and CC cord-258129-c38q6xxs 226 44 risk risk NN cord-258129-c38q6xxs 226 45 of of IN cord-258129-c38q6xxs 226 46 wheeze wheeze NN cord-258129-c38q6xxs 226 47 and and CC cord-258129-c38q6xxs 226 48 allergy allergy NN cord-258129-c38q6xxs 226 49 by by IN cord-258129-c38q6xxs 226 50 age age NN cord-258129-c38q6xxs 226 51 13 13 CD cord-258129-c38q6xxs 226 52 years year NNS cord-258129-c38q6xxs 227 1 Lipoxin Lipoxin NNP cord-258129-c38q6xxs 227 2 ( ( -LRB- cord-258129-c38q6xxs 227 3 LX LX NNP cord-258129-c38q6xxs 227 4 ) ) -RRB- cord-258129-c38q6xxs 227 5 A4 A4 NNP cord-258129-c38q6xxs 227 6 and and CC cord-258129-c38q6xxs 227 7 aspirin aspirin NN cord-258129-c38q6xxs 227 8 - - HYPH cord-258129-c38q6xxs 227 9 triggered trigger VBN cord-258129-c38q6xxs 227 10 15-epi 15-epi CD cord-258129-c38q6xxs 227 11 - - HYPH cord-258129-c38q6xxs 227 12 LXA4 LXA4 NNP cord-258129-c38q6xxs 227 13 inhibit inhibit NN cord-258129-c38q6xxs 227 14 tumor tumor NN cord-258129-c38q6xxs 227 15 necrosis necrosis NN cord-258129-c38q6xxs 227 16 factor factor NN cord-258129-c38q6xxs 227 17 1a 1a CD cord-258129-c38q6xxs 227 18 - - HYPH cord-258129-c38q6xxs 227 19 initiated initiate VBN cord-258129-c38q6xxs 227 20 neutrophil neutrophil NN cord-258129-c38q6xxs 227 21 responses response NNS cord-258129-c38q6xxs 227 22 and and CC cord-258129-c38q6xxs 227 23 trafficking trafficking NN cord-258129-c38q6xxs 227 24 : : : cord-258129-c38q6xxs 227 25 regulators regulator NNS cord-258129-c38q6xxs 227 26 of of IN cord-258129-c38q6xxs 227 27 a a DT cord-258129-c38q6xxs 227 28 cytokine cytokine JJ cord-258129-c38q6xxs 227 29 - - HYPH cord-258129-c38q6xxs 227 30 chemokine chemokine NN cord-258129-c38q6xxs 227 31 axis axis NN