id	sid	tid	token	lemma	pos
cord-262445-54ng7m92	1	1	key	key	JJ
cord-262445-54ng7m92	1	2	:	:	:
cord-262445-54ng7m92	1	3	cord-262445	cord-262445	NNP
cord-262445-54ng7m92	1	4	-	-	HYPH
cord-262445-54ng7m92	1	5	54ng7m92	54ng7m92	CD
cord-262445-54ng7m92	2	1	authors	author	NNS
cord-262445-54ng7m92	2	2	:	:	:
cord-262445-54ng7m92	2	3	Gabellini	Gabellini	NNP
cord-262445-54ng7m92	2	4	,	,	,
cord-262445-54ng7m92	2	5	Davide	Davide	NNP
cord-262445-54ng7m92	2	6	;	;	:
cord-262445-54ng7m92	2	7	Musarò	Musarò	NNP
cord-262445-54ng7m92	2	8	,	,	,
cord-262445-54ng7m92	2	9	Antonio	Antonio	NNP
cord-262445-54ng7m92	2	10	title	title	NN
cord-262445-54ng7m92	2	11	:	:	:
cord-262445-54ng7m92	2	12	16th	16th	JJ
cord-262445-54ng7m92	2	13	Meeting	Meeting	NNP
cord-262445-54ng7m92	2	14	of	of	IN
cord-262445-54ng7m92	2	15	the	the	DT
cord-262445-54ng7m92	2	16	Interuniversity	Interuniversity	NNP
cord-262445-54ng7m92	2	17	Institute	Institute	NNP
cord-262445-54ng7m92	2	18	of	of	IN
cord-262445-54ng7m92	2	19	Myology	Myology	NNP
cord-262445-54ng7m92	2	20	(	(	-LRB-
cord-262445-54ng7m92	2	21	IIM	IIM	NNP
cord-262445-54ng7m92	2	22	)	)	-RRB-
cord-262445-54ng7m92	2	23	-	-	:
cord-262445-54ng7m92	2	24	Assisi	Assisi	NNP
cord-262445-54ng7m92	2	25	(	(	-LRB-
cord-262445-54ng7m92	2	26	Italy	Italy	NNP
cord-262445-54ng7m92	2	27	)	)	-RRB-
cord-262445-54ng7m92	2	28	,	,	,
cord-262445-54ng7m92	2	29	October	October	NNP
cord-262445-54ng7m92	2	30	17	17	CD
cord-262445-54ng7m92	2	31	-	-	SYM
cord-262445-54ng7m92	2	32	20	20	CD
cord-262445-54ng7m92	2	33	,	,	,
cord-262445-54ng7m92	2	34	2019	2019	CD
cord-262445-54ng7m92	2	35	:	:	:
cord-262445-54ng7m92	3	1	Foreword	Foreword	NNP
cord-262445-54ng7m92	3	2	,	,	,
cord-262445-54ng7m92	3	3	Program	Program	NNP
cord-262445-54ng7m92	3	4	and	and	CC
cord-262445-54ng7m92	3	5	Abstracts	Abstracts	NNP
cord-262445-54ng7m92	3	6	date	date	NN
cord-262445-54ng7m92	3	7	:	:	:
cord-262445-54ng7m92	3	8	2020	2020	CD
cord-262445-54ng7m92	3	9	-	-	HYPH
cord-262445-54ng7m92	3	10	09	09	CD
cord-262445-54ng7m92	3	11	-	-	SYM
cord-262445-54ng7m92	3	12	15	15	CD
cord-262445-54ng7m92	3	13	journal	journal	NN
cord-262445-54ng7m92	3	14	:	:	:
cord-262445-54ng7m92	4	1	Eur	Eur	NNP
cord-262445-54ng7m92	4	2	J	J	NNP
cord-262445-54ng7m92	4	3	Transl	Transl	NNP
cord-262445-54ng7m92	5	1	Myol	Myol	NNP
cord-262445-54ng7m92	5	2	DOI	DOI	NNP
cord-262445-54ng7m92	5	3	:	:	:
cord-262445-54ng7m92	6	1	10.4081	10.4081	CD
cord-262445-54ng7m92	6	2	/	/	SYM
cord-262445-54ng7m92	6	3	ejtm.2020.9345	ejtm.2020.9345	NN
cord-262445-54ng7m92	6	4	sha	sha	NNP
cord-262445-54ng7m92	6	5	:	:	:
cord-262445-54ng7m92	7	1	4543923661116e811380838502dd4141e6446489	4543923661116e811380838502dd4141e6446489	LS
cord-262445-54ng7m92	7	2	doc_id	doc_id	CD
cord-262445-54ng7m92	7	3	:	:	:
cord-262445-54ng7m92	7	4	262445	262445	CD
cord-262445-54ng7m92	7	5	cord_uid	cord_uid	NNS
cord-262445-54ng7m92	7	6	:	:	:
cord-262445-54ng7m92	8	1	54ng7m92	54ng7m92	CD
cord-262445-54ng7m92	9	1	The	the	DT
cord-262445-54ng7m92	9	2	16th	16th	JJ
cord-262445-54ng7m92	9	3	Meeting	Meeting	NNP
cord-262445-54ng7m92	9	4	of	of	IN
cord-262445-54ng7m92	9	5	the	the	DT
cord-262445-54ng7m92	9	6	Interuniversity	Interuniversity	NNP
cord-262445-54ng7m92	9	7	Institute	Institute	NNP
cord-262445-54ng7m92	9	8	of	of	IN
cord-262445-54ng7m92	9	9	Myology	Myology	NNP
cord-262445-54ng7m92	9	10	(	(	-LRB-
cord-262445-54ng7m92	9	11	IIM	IIM	NNP
cord-262445-54ng7m92	9	12	)	)	-RRB-
cord-262445-54ng7m92	9	13	,	,	,
cord-262445-54ng7m92	9	14	October	October	NNP
cord-262445-54ng7m92	9	15	17	17	CD
cord-262445-54ng7m92	9	16	-	-	SYM
cord-262445-54ng7m92	9	17	20	20	CD
cord-262445-54ng7m92	9	18	,	,	,
cord-262445-54ng7m92	9	19	2019	2019	CD
cord-262445-54ng7m92	9	20	,	,	,
cord-262445-54ng7m92	9	21	Assisi	Assisi	NNP
cord-262445-54ng7m92	9	22	,	,	,
cord-262445-54ng7m92	9	23	Italy	Italy	NNP
cord-262445-54ng7m92	9	24	brought	bring	VBD
cord-262445-54ng7m92	9	25	together	together	RB
cord-262445-54ng7m92	9	26	scientists	scientist	NNS
cord-262445-54ng7m92	9	27	,	,	,
cord-262445-54ng7m92	9	28	pharma	pharma	NNS
cord-262445-54ng7m92	9	29	and	and	CC
cord-262445-54ng7m92	9	30	patient	patient	NNP
cord-262445-54ng7m92	9	31	organization	organization	NN
cord-262445-54ng7m92	9	32	representatives	representative	NNS
cord-262445-54ng7m92	9	33	discussing	discuss	VBG
cord-262445-54ng7m92	9	34	new	new	JJ
cord-262445-54ng7m92	9	35	results	result	NNS
cord-262445-54ng7m92	9	36	on	on	IN
cord-262445-54ng7m92	9	37	muscle	muscle	NN
cord-262445-54ng7m92	9	38	research	research	NN
cord-262445-54ng7m92	9	39	.	.	.
cord-262445-54ng7m92	10	1	Internationally	internationally	RB
cord-262445-54ng7m92	10	2	renowned	renowned	JJ
cord-262445-54ng7m92	10	3	Keynote	Keynote	NNP
cord-262445-54ng7m92	10	4	speakers	speaker	NNS
cord-262445-54ng7m92	10	5	presented	present	VBD
cord-262445-54ng7m92	10	6	advances	advance	NNS
cord-262445-54ng7m92	10	7	on	on	IN
cord-262445-54ng7m92	10	8	muscle	muscle	NN
cord-262445-54ng7m92	10	9	development	development	NN
cord-262445-54ng7m92	10	10	,	,	,
cord-262445-54ng7m92	10	11	homeostasis	homeostasis	NN
cord-262445-54ng7m92	10	12	,	,	,
cord-262445-54ng7m92	10	13	metabolism	metabolism	NN
cord-262445-54ng7m92	10	14	,	,	,
cord-262445-54ng7m92	10	15	and	and	CC
cord-262445-54ng7m92	10	16	disease	disease	NN
cord-262445-54ng7m92	10	17	.	.	.
cord-262445-54ng7m92	11	1	Speakers	speaker	NNS
cord-262445-54ng7m92	11	2	selected	select	VBN
cord-262445-54ng7m92	11	3	among	among	IN
cord-262445-54ng7m92	11	4	submitted	submit	VBN
cord-262445-54ng7m92	11	5	abstracts	abstract	NNS
cord-262445-54ng7m92	11	6	presented	present	VBD
cord-262445-54ng7m92	11	7	their	-PRON-	PRP$
cord-262445-54ng7m92	11	8	new	new	JJ
cord-262445-54ng7m92	11	9	,	,	,
cord-262445-54ng7m92	11	10	unpublished	unpublished	JJ
cord-262445-54ng7m92	11	11	data	datum	NNS
cord-262445-54ng7m92	11	12	in	in	IN
cord-262445-54ng7m92	11	13	seven	seven	CD
cord-262445-54ng7m92	11	14	scientific	scientific	JJ
cord-262445-54ng7m92	11	15	sessions	session	NNS
cord-262445-54ng7m92	11	16	.	.	.
cord-262445-54ng7m92	12	1	The	the	DT
cord-262445-54ng7m92	12	2	remaining	remain	VBG
cord-262445-54ng7m92	12	3	abstracts	abstract	NNS
cord-262445-54ng7m92	12	4	were	be	VBD
cord-262445-54ng7m92	12	5	showcased	showcase	VBN
cord-262445-54ng7m92	12	6	in	in	IN
cord-262445-54ng7m92	12	7	two	two	CD
cord-262445-54ng7m92	12	8	poster	poster	NN
cord-262445-54ng7m92	12	9	sessions	session	NNS
cord-262445-54ng7m92	12	10	.	.	.
cord-262445-54ng7m92	13	1	Young	young	JJ
cord-262445-54ng7m92	13	2	trainees	trainee	NNS
cord-262445-54ng7m92	13	3	where	where	WRB
cord-262445-54ng7m92	13	4	directly	directly	RB
cord-262445-54ng7m92	13	5	involved	involve	VBN
cord-262445-54ng7m92	13	6	in	in	IN
cord-262445-54ng7m92	13	7	the	the	DT
cord-262445-54ng7m92	13	8	selection	selection	NN
cord-262445-54ng7m92	13	9	of	of	IN
cord-262445-54ng7m92	13	10	keynote	keynote	JJ
cord-262445-54ng7m92	13	11	speakers	speaker	NNS
cord-262445-54ng7m92	13	12	,	,	,
cord-262445-54ng7m92	13	13	the	the	DT
cord-262445-54ng7m92	13	14	organizing	organize	VBG
cord-262445-54ng7m92	13	15	scientific	scientific	JJ
cord-262445-54ng7m92	13	16	sessions	session	NNS
cord-262445-54ng7m92	13	17	and	and	CC
cord-262445-54ng7m92	13	18	roundtables	roundtable	NNS
cord-262445-54ng7m92	13	19	discussions	discussion	NNS
cord-262445-54ng7m92	13	20	tailored	tailor	VBN
cord-262445-54ng7m92	13	21	to	to	IN
cord-262445-54ng7m92	13	22	the	the	DT
cord-262445-54ng7m92	13	23	interests	interest	NNS
cord-262445-54ng7m92	13	24	of	of	IN
cord-262445-54ng7m92	13	25	their	-PRON-	PRP$
cord-262445-54ng7m92	13	26	peers	peer	NNS
cord-262445-54ng7m92	13	27	.	.	.
cord-262445-54ng7m92	14	1	A	a	DT
cord-262445-54ng7m92	14	2	broad	broad	JJ
cord-262445-54ng7m92	14	3	Italian	italian	JJ
cord-262445-54ng7m92	14	4	,	,	,
cord-262445-54ng7m92	14	5	European	european	JJ
cord-262445-54ng7m92	14	6	and	and	CC
cord-262445-54ng7m92	14	7	North	north	JJ
cord-262445-54ng7m92	14	8	-	-	HYPH
cord-262445-54ng7m92	14	9	American	american	JJ
cord-262445-54ng7m92	14	10	audience	audience	NN
cord-262445-54ng7m92	14	11	participated	participate	VBD
cord-262445-54ng7m92	14	12	to	to	IN
cord-262445-54ng7m92	14	13	the	the	DT
cord-262445-54ng7m92	14	14	different	different	JJ
cord-262445-54ng7m92	14	15	initiatives	initiative	NNS
cord-262445-54ng7m92	14	16	.	.	.
cord-262445-54ng7m92	15	1	The	the	DT
cord-262445-54ng7m92	15	2	meeting	meeting	NN
cord-262445-54ng7m92	15	3	allowed	allow	VBD
cord-262445-54ng7m92	15	4	muscle	muscle	NN
cord-262445-54ng7m92	15	5	biology	biology	NN
cord-262445-54ng7m92	15	6	researchers	researcher	NNS
cord-262445-54ng7m92	15	7	to	to	TO
cord-262445-54ng7m92	15	8	discuss	discuss	VB
cord-262445-54ng7m92	15	9	ideas	idea	NNS
cord-262445-54ng7m92	15	10	and	and	CC
cord-262445-54ng7m92	15	11	scientific	scientific	JJ
cord-262445-54ng7m92	15	12	collaborations	collaboration	NNS
cord-262445-54ng7m92	15	13	aimed	aim	VBN
cord-262445-54ng7m92	15	14	at	at	IN
cord-262445-54ng7m92	15	15	better	well	JJR
cord-262445-54ng7m92	15	16	understanding	understand	VBG
cord-262445-54ng7m92	15	17	the	the	DT
cord-262445-54ng7m92	15	18	mechanisms	mechanism	NNS
cord-262445-54ng7m92	15	19	underlying	underlie	VBG
cord-262445-54ng7m92	15	20	muscle	muscle	NN
cord-262445-54ng7m92	15	21	diseases	disease	NNS
cord-262445-54ng7m92	15	22	in	in	IN
cord-262445-54ng7m92	15	23	order	order	NN
cord-262445-54ng7m92	15	24	to	to	TO
cord-262445-54ng7m92	15	25	develop	develop	VB
cord-262445-54ng7m92	15	26	better	well	JJR
cord-262445-54ng7m92	15	27	therapeutic	therapeutic	JJ
cord-262445-54ng7m92	15	28	strategies	strategy	NNS
cord-262445-54ng7m92	15	29	.	.	.
cord-262445-54ng7m92	16	1	The	the	DT
cord-262445-54ng7m92	16	2	active	active	JJ
cord-262445-54ng7m92	16	3	participation	participation	NN
cord-262445-54ng7m92	16	4	of	of	IN
cord-262445-54ng7m92	16	5	young	young	JJ
cord-262445-54ng7m92	16	6	trainees	trainee	NNS
cord-262445-54ng7m92	16	7	was	be	VBD
cord-262445-54ng7m92	16	8	facilitated	facilitate	VBN
cord-262445-54ng7m92	16	9	by	by	IN
cord-262445-54ng7m92	16	10	the	the	DT
cord-262445-54ng7m92	16	11	friendly	friendly	JJ
cord-262445-54ng7m92	16	12	and	and	CC
cord-262445-54ng7m92	16	13	inclusive	inclusive	JJ
cord-262445-54ng7m92	16	14	atmosphere	atmosphere	NN
cord-262445-54ng7m92	16	15	,	,	,
cord-262445-54ng7m92	16	16	which	which	WDT
cord-262445-54ng7m92	16	17	fostered	foster	VBD
cord-262445-54ng7m92	16	18	lively	lively	JJ
cord-262445-54ng7m92	16	19	discussions	discussion	NNS
cord-262445-54ng7m92	16	20	identifying	identify	VBG
cord-262445-54ng7m92	16	21	emerging	emerge	VBG
cord-262445-54ng7m92	16	22	areas	area	NNS
cord-262445-54ng7m92	16	23	of	of	IN
cord-262445-54ng7m92	16	24	myology	myology	NN
cord-262445-54ng7m92	16	25	research	research	NN
cord-262445-54ng7m92	16	26	and	and	CC
cord-262445-54ng7m92	16	27	stimulated	stimulate	VBD
cord-262445-54ng7m92	16	28	scientific	scientific	JJ
cord-262445-54ng7m92	16	29	cross	cross	NN
cord-262445-54ng7m92	16	30	-	-	NN
cord-262445-54ng7m92	16	31	fertilization	fertilization	NN
cord-262445-54ng7m92	16	32	.	.	.
cord-262445-54ng7m92	17	1	The	the	DT
cord-262445-54ng7m92	17	2	meeting	meeting	NN
cord-262445-54ng7m92	17	3	was	be	VBD
cord-262445-54ng7m92	17	4	a	a	DT
cord-262445-54ng7m92	17	5	success	success	NN
cord-262445-54ng7m92	17	6	and	and	CC
cord-262445-54ng7m92	17	7	the	the	DT
cord-262445-54ng7m92	17	8	IIM	IIM	NNP
cord-262445-54ng7m92	17	9	community	community	NN
cord-262445-54ng7m92	17	10	will	will	MD
cord-262445-54ng7m92	17	11	continue	continue	VB
cord-262445-54ng7m92	17	12	to	to	TO
cord-262445-54ng7m92	17	13	bring	bring	VB
cord-262445-54ng7m92	17	14	forward	forward	RB
cord-262445-54ng7m92	17	15	significant	significant	JJ
cord-262445-54ng7m92	17	16	contributions	contribution	NNS
cord-262445-54ng7m92	17	17	to	to	IN
cord-262445-54ng7m92	17	18	the	the	DT
cord-262445-54ng7m92	17	19	understanding	understanding	NN
cord-262445-54ng7m92	17	20	of	of	IN
cord-262445-54ng7m92	17	21	muscle	muscle	NN
cord-262445-54ng7m92	17	22	development	development	NN
cord-262445-54ng7m92	17	23	and	and	CC
cord-262445-54ng7m92	17	24	function	function	NN
cord-262445-54ng7m92	17	25	,	,	,
cord-262445-54ng7m92	17	26	the	the	DT
cord-262445-54ng7m92	17	27	pathogenesis	pathogenesis	NN
cord-262445-54ng7m92	17	28	of	of	IN
cord-262445-54ng7m92	17	29	muscular	muscular	JJ
cord-262445-54ng7m92	17	30	diseases	disease	NNS
cord-262445-54ng7m92	17	31	and	and	CC
cord-262445-54ng7m92	17	32	the	the	DT
cord-262445-54ng7m92	17	33	development	development	NN
cord-262445-54ng7m92	17	34	of	of	IN
cord-262445-54ng7m92	17	35	novel	novel	JJ
cord-262445-54ng7m92	17	36	therapeutic	therapeutic	JJ
cord-262445-54ng7m92	17	37	approaches	approach	NNS
cord-262445-54ng7m92	17	38	.	.	.
cord-262445-54ng7m92	18	1	Here	here	RB
cord-262445-54ng7m92	18	2	,	,	,
cord-262445-54ng7m92	18	3	we	-PRON-	PRP
cord-262445-54ng7m92	18	4	report	report	VBP
cord-262445-54ng7m92	18	5	abstracts	abstract	NNS
cord-262445-54ng7m92	18	6	of	of	IN
cord-262445-54ng7m92	18	7	the	the	DT
cord-262445-54ng7m92	18	8	meeting	meeting	NN
cord-262445-54ng7m92	18	9	illustrating	illustrate	VBG
cord-262445-54ng7m92	18	10	novel	novel	JJ
cord-262445-54ng7m92	18	11	results	result	NNS
cord-262445-54ng7m92	18	12	of	of	IN
cord-262445-54ng7m92	18	13	basic	basic	JJ
cord-262445-54ng7m92	18	14	,	,	,
cord-262445-54ng7m92	18	15	translational	translational	JJ
cord-262445-54ng7m92	18	16	,	,	,
cord-262445-54ng7m92	18	17	and	and	CC
cord-262445-54ng7m92	18	18	clinical	clinical	JJ
cord-262445-54ng7m92	18	19	research	research	NN
cord-262445-54ng7m92	18	20	,	,	,
cord-262445-54ng7m92	18	21	which	which	WDT
cord-262445-54ng7m92	18	22	confirms	confirm	VBZ
cord-262445-54ng7m92	18	23	that	that	IN
cord-262445-54ng7m92	18	24	the	the	DT
cord-262445-54ng7m92	18	25	Myology	Myology	NNP
cord-262445-54ng7m92	18	26	field	field	NN
cord-262445-54ng7m92	18	27	is	be	VBZ
cord-262445-54ng7m92	18	28	strong	strong	JJ
cord-262445-54ng7m92	18	29	and	and	CC
cord-262445-54ng7m92	18	30	healthy	healthy	JJ
cord-262445-54ng7m92	18	31	.	.	.
cord-262445-54ng7m92	19	1	-2	-2	LS
cord-262445-54ng7m92	20	1	-associated	-associate	VBN
cord-262445-54ng7m92	20	2	with	with	IN
cord-262445-54ng7m92	20	3	muscle	muscle	NN
cord-262445-54ng7m92	20	4	diseases	disease	NNS
cord-262445-54ng7m92	20	5	.	.	.
cord-262445-54ng7m92	21	1	1	1	LS
cord-262445-54ng7m92	21	2	Leading	lead	VBG
cord-262445-54ng7m92	21	3	experts	expert	NNS
cord-262445-54ng7m92	21	4	of	of	IN
cord-262445-54ng7m92	21	5	the	the	DT
cord-262445-54ng7m92	21	6	muscle	muscle	NN
cord-262445-54ng7m92	21	7	field	field	NN
cord-262445-54ng7m92	21	8	,	,	,
cord-262445-54ng7m92	21	9	along	along	IN
cord-262445-54ng7m92	21	10	with	with	IN
cord-262445-54ng7m92	21	11	speakers	speaker	NNS
cord-262445-54ng7m92	21	12	selected	select	VBN
cord-262445-54ng7m92	21	13	from	from	IN
cord-262445-54ng7m92	21	14	submitted	submit	VBN
cord-262445-54ng7m92	21	15	abstracts	abstract	NNS
cord-262445-54ng7m92	21	16	,	,	,
cord-262445-54ng7m92	21	17	provided	provide	VBD
cord-262445-54ng7m92	21	18	important	important	JJ
cord-262445-54ng7m92	21	19	insights	insight	NNS
cord-262445-54ng7m92	21	20	into	into	IN
cord-262445-54ng7m92	21	21	the	the	DT
cord-262445-54ng7m92	21	22	extracellular	extracellular	JJ
cord-262445-54ng7m92	21	23	agonists	agonist	NNS
cord-262445-54ng7m92	21	24	,	,	,
cord-262445-54ng7m92	21	25	receptors	receptor	NNS
cord-262445-54ng7m92	21	26	,	,	,
cord-262445-54ng7m92	21	27	protein	protein	NN
cord-262445-54ng7m92	21	28	kinases	kinase	NNS
cord-262445-54ng7m92	21	29	,	,	,
cord-262445-54ng7m92	21	30	intermediate	intermediate	JJ
cord-262445-54ng7m92	21	31	molecules	molecule	NNS
cord-262445-54ng7m92	21	32	,	,	,
cord-262445-54ng7m92	21	33	transcription	transcription	NN
cord-262445-54ng7m92	21	34	factors	factor	NNS
cord-262445-54ng7m92	21	35	,	,	,
cord-262445-54ng7m92	21	36	and	and	CC
cord-262445-54ng7m92	21	37	epigenetic	epigenetic	JJ
cord-262445-54ng7m92	21	38	mechanisms	mechanism	NNS
cord-262445-54ng7m92	21	39	involved	involve	VBN
cord-262445-54ng7m92	21	40	in	in	IN
cord-262445-54ng7m92	21	41	the	the	DT
cord-262445-54ng7m92	21	42	modulation	modulation	NN
cord-262445-54ng7m92	21	43	of	of	IN
cord-262445-54ng7m92	21	44	specific	specific	JJ
cord-262445-54ng7m92	21	45	cellular	cellular	JJ
cord-262445-54ng7m92	21	46	responses	response	NNS
cord-262445-54ng7m92	21	47	in	in	IN
cord-262445-54ng7m92	21	48	embryonic	embryonic	JJ
cord-262445-54ng7m92	21	49	and	and	CC
cord-262445-54ng7m92	21	50	adult	adult	NN
cord-262445-54ng7m92	21	51	myocytes	myocyte	NNS
cord-262445-54ng7m92	21	52	/	/	SYM
cord-262445-54ng7m92	21	53	myofibers	myofiber	NNS
cord-262445-54ng7m92	21	54	.	.	.
cord-262445-54ng7m92	22	1	[	[	-LRB-
cord-262445-54ng7m92	22	2	2	2	LS
cord-262445-54ng7m92	22	3	]	]	-RRB-
cord-262445-54ng7m92	22	4	[	[	-LRB-
cord-262445-54ng7m92	22	5	3	3	CD
cord-262445-54ng7m92	22	6	]	]	-RRB-
cord-262445-54ng7m92	22	7	[	[	-LRB-
cord-262445-54ng7m92	22	8	4	4	CD
cord-262445-54ng7m92	22	9	]	]	-RRB-
cord-262445-54ng7m92	23	1	[	[	-LRB-
cord-262445-54ng7m92	23	2	5	5	CD
cord-262445-54ng7m92	23	3	]	]	-RRB-
cord-262445-54ng7m92	23	4	Olivier	Olivier	NNP
cord-262445-54ng7m92	23	5	Pourquié	Pourquié	NNP
cord-262445-54ng7m92	23	6	demonstrated	demonstrate	VBD
cord-262445-54ng7m92	23	7	that	that	IN
cord-262445-54ng7m92	23	8	,	,	,
cord-262445-54ng7m92	23	9	mimicking	mimic	VBG
cord-262445-54ng7m92	23	10	key	key	JJ
cord-262445-54ng7m92	23	11	signaling	signal	VBG
cord-262445-54ng7m92	23	12	events	event	NNS
cord-262445-54ng7m92	23	13	leading	lead	VBG
cord-262445-54ng7m92	23	14	to	to	IN
cord-262445-54ng7m92	23	15	muscle	muscle	NN
cord-262445-54ng7m92	23	16	formation	formation	NN
cord-262445-54ng7m92	23	17	in	in	IN
cord-262445-54ng7m92	23	18	the	the	DT
cord-262445-54ng7m92	23	19	embryo	embryo	NN
cord-262445-54ng7m92	23	20	,	,	,
cord-262445-54ng7m92	23	21	it	-PRON-	PRP
cord-262445-54ng7m92	23	22	is	be	VBZ
cord-262445-54ng7m92	23	23	possible	possible	JJ
cord-262445-54ng7m92	23	24	to	to	TO
cord-262445-54ng7m92	23	25	efficiently	efficiently	RB
cord-262445-54ng7m92	23	26	produce	produce	VB
cord-262445-54ng7m92	23	27	striated	striated	JJ
cord-262445-54ng7m92	23	28	,	,	,
cord-262445-54ng7m92	23	29	millimeter	millimeter	NN
cord-262445-54ng7m92	23	30	-	-	HYPH
cord-262445-54ng7m92	23	31	long	long	JJ
cord-262445-54ng7m92	23	32	muscle	muscle	NN
cord-262445-54ng7m92	23	33	fibers	fiber	NNS
cord-262445-54ng7m92	23	34	together	together	RB
cord-262445-54ng7m92	23	35	with	with	IN
cord-262445-54ng7m92	23	36	satellite	satellite	NN
cord-262445-54ng7m92	23	37	-	-	HYPH
cord-262445-54ng7m92	23	38	like	like	JJ
cord-262445-54ng7m92	23	39	cells	cell	NNS
cord-262445-54ng7m92	23	40	from	from	IN
cord-262445-54ng7m92	23	41	human	human	JJ
cord-262445-54ng7m92	23	42	pluripotent	pluripotent	JJ
cord-262445-54ng7m92	23	43	stem	stem	NN
cord-262445-54ng7m92	23	44	cells	cell	NNS
cord-262445-54ng7m92	23	45	(	(	-LRB-
cord-262445-54ng7m92	23	46	ES	ES	NNP
cord-262445-54ng7m92	23	47	/	/	SYM
cord-262445-54ng7m92	23	48	iPS	iPS	NNP
cord-262445-54ng7m92	23	49	)	)	-RRB-
cord-262445-54ng7m92	23	50	,	,	,
cord-262445-54ng7m92	23	51	avoiding	avoid	VBG
cord-262445-54ng7m92	23	52	the	the	DT
cord-262445-54ng7m92	23	53	requirement	requirement	NN
cord-262445-54ng7m92	23	54	for	for	IN
cord-262445-54ng7m92	23	55	genetic	genetic	JJ
cord-262445-54ng7m92	23	56	modifications	modification	NNS
cord-262445-54ng7m92	23	57	or	or	CC
cord-262445-54ng7m92	23	58	cell	cell	NN
cord-262445-54ng7m92	23	59	sorting	sorting	NN
cord-262445-54ng7m92	23	60	.	.	.
cord-262445-54ng7m92	24	1	Bente	Bente	NNP
cord-262445-54ng7m92	24	2	Klarlund	Klarlund	NNP
cord-262445-54ng7m92	24	3	Pedersen	Pedersen	NNP
cord-262445-54ng7m92	24	4	discussed	discuss	VBD
cord-262445-54ng7m92	24	5	the	the	DT
cord-262445-54ng7m92	24	6	important	important	JJ
cord-262445-54ng7m92	24	7	role	role	NN
cord-262445-54ng7m92	24	8	of	of	IN
cord-262445-54ng7m92	24	9	skeletal	skeletal	JJ
cord-262445-54ng7m92	24	10	muscle	muscle	NN
cord-262445-54ng7m92	24	11	as	as	IN
cord-262445-54ng7m92	24	12	an	an	DT
cord-262445-54ng7m92	24	13	endocrine	endocrine	JJ
cord-262445-54ng7m92	24	14	organ	organ	NN
cord-262445-54ng7m92	24	15	,	,	,
cord-262445-54ng7m92	24	16	which	which	WDT
cord-262445-54ng7m92	24	17	has	have	VBZ
cord-262445-54ng7m92	24	18	the	the	DT
cord-262445-54ng7m92	24	19	capacity	capacity	NN
cord-262445-54ng7m92	24	20	to	to	TO
cord-262445-54ng7m92	24	21	produce	produce	VB
cord-262445-54ng7m92	24	22	hundreds	hundred	NNS
cord-262445-54ng7m92	24	23	of	of	IN
cord-262445-54ng7m92	24	24	myokines	myokine	NNS
cord-262445-54ng7m92	24	25	,	,	,
cord-262445-54ng7m92	24	26	providing	provide	VBG
cord-262445-54ng7m92	24	27	a	a	DT
cord-262445-54ng7m92	24	28	conceptual	conceptual	JJ
cord-262445-54ng7m92	24	29	basis	basis	NN
cord-262445-54ng7m92	24	30	for	for	IN
cord-262445-54ng7m92	24	31	understanding	understand	VBG
cord-262445-54ng7m92	24	32	how	how	WRB
cord-262445-54ng7m92	24	33	muscles	muscle	NNS
cord-262445-54ng7m92	24	34	communicate	communicate	VBP
cord-262445-54ng7m92	24	35	with	with	IN
cord-262445-54ng7m92	24	36	other	other	JJ
cord-262445-54ng7m92	24	37	organs	organ	NNS
cord-262445-54ng7m92	24	38	such	such	JJ
cord-262445-54ng7m92	24	39	as	as	IN
cord-262445-54ng7m92	24	40	adipose	adipose	JJ
cord-262445-54ng7m92	24	41	tissue	tissue	NN
cord-262445-54ng7m92	24	42	,	,	,
cord-262445-54ng7m92	24	43	liver	liver	NN
cord-262445-54ng7m92	24	44	,	,	,
cord-262445-54ng7m92	24	45	pancreas	pancrea	NNS
cord-262445-54ng7m92	24	46	,	,	,
cord-262445-54ng7m92	24	47	bones	bone	NNS
cord-262445-54ng7m92	24	48	,	,	,
cord-262445-54ng7m92	24	49	and	and	CC
cord-262445-54ng7m92	24	50	brain	brain	NN
cord-262445-54ng7m92	24	51	.	.	.
cord-262445-54ng7m92	25	1	Alessandra	Alessandra	NNP
cord-262445-54ng7m92	25	2	Sacco	Sacco	NNP
cord-262445-54ng7m92	25	3	discussed	discuss	VBD
cord-262445-54ng7m92	25	4	the	the	DT
cord-262445-54ng7m92	25	5	dynamics	dynamic	NNS
cord-262445-54ng7m92	25	6	of	of	IN
cord-262445-54ng7m92	25	7	muscle	muscle	NN
cord-262445-54ng7m92	25	8	stem	stem	NN
cord-262445-54ng7m92	25	9	cells	cell	NNS
cord-262445-54ng7m92	25	10	during	during	IN
cord-262445-54ng7m92	25	11	tissue	tissue	NN
cord-262445-54ng7m92	25	12	growth	growth	NN
cord-262445-54ng7m92	25	13	and	and	CC
cord-262445-54ng7m92	25	14	regeneration	regeneration	NN
cord-262445-54ng7m92	25	15	,	,	,
cord-262445-54ng7m92	25	16	whereas	whereas	IN
cord-262445-54ng7m92	25	17	Bénédicte	Bénédicte	NNP
cord-262445-54ng7m92	25	18	Chazaud	Chazaud	NNP
cord-262445-54ng7m92	25	19	discussed	discuss	VBD
cord-262445-54ng7m92	25	20	the	the	DT
cord-262445-54ng7m92	25	21	roles	role	NNS
cord-262445-54ng7m92	25	22	of	of	IN
cord-262445-54ng7m92	25	23	macrophages	macrophage	NNS
cord-262445-54ng7m92	25	24	in	in	IN
cord-262445-54ng7m92	25	25	normal	normal	JJ
cord-262445-54ng7m92	25	26	skeletal	skeletal	JJ
cord-262445-54ng7m92	25	27	muscle	muscle	NN
cord-262445-54ng7m92	25	28	regeneration	regeneration	NN
cord-262445-54ng7m92	25	29	versus	versus	IN
cord-262445-54ng7m92	25	30	muscle	muscle	NN
cord-262445-54ng7m92	25	31	disease	disease	NN
cord-262445-54ng7m92	25	32	.	.	.
cord-262445-54ng7m92	26	1	Muscle	muscle	NN
cord-262445-54ng7m92	26	2	regeneration	regeneration	NN
cord-262445-54ng7m92	26	3	recapitulates	recapitulate	VBZ
cord-262445-54ng7m92	26	4	many	many	JJ
cord-262445-54ng7m92	26	5	aspects	aspect	NNS
cord-262445-54ng7m92	26	6	of	of	IN
cord-262445-54ng7m92	26	7	embryonic	embryonic	JJ
cord-262445-54ng7m92	26	8	myogenesis	myogenesis	NN
cord-262445-54ng7m92	26	9	and	and	CC
cord-262445-54ng7m92	26	10	it	-PRON-	PRP
cord-262445-54ng7m92	26	11	is	be	VBZ
cord-262445-54ng7m92	26	12	an	an	DT
cord-262445-54ng7m92	26	13	important	important	JJ
cord-262445-54ng7m92	26	14	homeostatic	homeostatic	JJ
cord-262445-54ng7m92	26	15	process	process	NN
cord-262445-54ng7m92	26	16	of	of	IN
cord-262445-54ng7m92	26	17	adult	adult	JJ
cord-262445-54ng7m92	26	18	skeletal	skeletal	JJ
cord-262445-54ng7m92	26	19	muscle	muscle	NN
cord-262445-54ng7m92	26	20	,	,	,
cord-262445-54ng7m92	26	21	which	which	WDT
cord-262445-54ng7m92	26	22	,	,	,
cord-262445-54ng7m92	26	23	after	after	IN
cord-262445-54ng7m92	26	24	development	development	NN
cord-262445-54ng7m92	26	25	,	,	,
cord-262445-54ng7m92	26	26	retains	retain	VBZ
cord-262445-54ng7m92	26	27	the	the	DT
cord-262445-54ng7m92	26	28	capacity	capacity	NN
cord-262445-54ng7m92	26	29	to	to	TO
cord-262445-54ng7m92	26	30	regenerate	regenerate	VB
cord-262445-54ng7m92	26	31	in	in	IN
cord-262445-54ng7m92	26	32	response	response	NN
cord-262445-54ng7m92	26	33	to	to	IN
cord-262445-54ng7m92	26	34	appropriate	appropriate	JJ
cord-262445-54ng7m92	26	35	stimuli	stimulus	NNS
cord-262445-54ng7m92	26	36	,	,	,
cord-262445-54ng7m92	26	37	activating	activate	VBG
cord-262445-54ng7m92	26	38	the	the	DT
cord-262445-54ng7m92	26	39	muscle	muscle	NN
cord-262445-54ng7m92	26	40	compartment	compartment	NN
cord-262445-54ng7m92	26	41	of	of	IN
cord-262445-54ng7m92	26	42	stem	stem	NN
cord-262445-54ng7m92	26	43	cells	cell	NNS
cord-262445-54ng7m92	26	44	,	,	,
cord-262445-54ng7m92	26	45	namely	namely	RB
cord-262445-54ng7m92	26	46	satellite	satellite	NN
cord-262445-54ng7m92	26	47	cells	cell	NNS
cord-262445-54ng7m92	26	48	,	,	,
cord-262445-54ng7m92	26	49	and	and	CC
cord-262445-54ng7m92	26	50	other	other	JJ
cord-262445-54ng7m92	26	51	precursor	precursor	NN
cord-262445-54ng7m92	26	52	cells	cell	NNS
cord-262445-54ng7m92	26	53	.	.	.
cord-262445-54ng7m92	27	1	3	3	LS
cord-262445-54ng7m92	27	2	,	,	,
cord-262445-54ng7m92	27	3	[	[	-LRB-
cord-262445-54ng7m92	27	4	6	6	CD
cord-262445-54ng7m92	27	5	]	]	-RRB-
cord-262445-54ng7m92	27	6	[	[	-LRB-
cord-262445-54ng7m92	27	7	7	7	CD
cord-262445-54ng7m92	27	8	]	]	-RRB-
cord-262445-54ng7m92	27	9	[	[	-LRB-
cord-262445-54ng7m92	27	10	8	8	CD
cord-262445-54ng7m92	27	11	]	]	-RRB-
cord-262445-54ng7m92	28	1	Skeletal	skeletal	JJ
cord-262445-54ng7m92	28	2	muscle	muscle	NN
cord-262445-54ng7m92	28	3	stem	stem	NN
cord-262445-54ng7m92	28	4	cells	cell	NNS
cord-262445-54ng7m92	28	5	(	(	-LRB-
cord-262445-54ng7m92	28	6	MuSC	MuSC	NNP
cord-262445-54ng7m92	28	7	)	)	-RRB-
cord-262445-54ng7m92	28	8	,	,	,
cord-262445-54ng7m92	28	9	also	also	RB
cord-262445-54ng7m92	28	10	known	know	VBN
cord-262445-54ng7m92	28	11	as	as	IN
cord-262445-54ng7m92	28	12	satellite	satellite	NN
cord-262445-54ng7m92	28	13	cells	cell	NNS
cord-262445-54ng7m92	28	14	,	,	,
cord-262445-54ng7m92	28	15	are	be	VBP
cord-262445-54ng7m92	28	16	the	the	DT
cord-262445-54ng7m92	28	17	main	main	JJ
cord-262445-54ng7m92	28	18	source	source	NN
cord-262445-54ng7m92	28	19	of	of	IN
cord-262445-54ng7m92	28	20	skeletal	skeletal	JJ
cord-262445-54ng7m92	28	21	muscle	muscle	NN
cord-262445-54ng7m92	28	22	growth	growth	NN
cord-262445-54ng7m92	28	23	and	and	CC
cord-262445-54ng7m92	28	24	regeneration	regeneration	NN
cord-262445-54ng7m92	28	25	.	.	.
cord-262445-54ng7m92	29	1	Within	within	IN
cord-262445-54ng7m92	29	2	their	-PRON-	PRP$
cord-262445-54ng7m92	29	3	native	native	JJ
cord-262445-54ng7m92	29	4	tissue	tissue	NN
cord-262445-54ng7m92	29	5	microenvironment	microenvironment	NN
cord-262445-54ng7m92	29	6	,	,	,
cord-262445-54ng7m92	29	7	or	or	CC
cord-262445-54ng7m92	29	8	stem	stem	NN
cord-262445-54ng7m92	29	9	cell	cell	NN
cord-262445-54ng7m92	29	10	niche	niche	NN
cord-262445-54ng7m92	29	11	,	,	,
cord-262445-54ng7m92	29	12	they	-PRON-	PRP
cord-262445-54ng7m92	29	13	are	be	VBP
cord-262445-54ng7m92	29	14	exposed	expose	VBN
cord-262445-54ng7m92	29	15	to	to	IN
cord-262445-54ng7m92	29	16	signals	signal	NNS
cord-262445-54ng7m92	29	17	emanating	emanate	VBG
cord-262445-54ng7m92	29	18	from	from	IN
cord-262445-54ng7m92	29	19	neighboring	neighboring	NN
cord-262445-54ng7m92	29	20	cells	cell	NNS
cord-262445-54ng7m92	29	21	,	,	,
cord-262445-54ng7m92	29	22	as	as	RB
cord-262445-54ng7m92	29	23	well	well	RB
cord-262445-54ng7m92	29	24	as	as	IN
cord-262445-54ng7m92	29	25	the	the	DT
cord-262445-54ng7m92	29	26	extracellular	extracellular	JJ
cord-262445-54ng7m92	29	27	space	space	NN
cord-262445-54ng7m92	29	28	that	that	WDT
cord-262445-54ng7m92	29	29	instruct	instruct	VBP
cord-262445-54ng7m92	29	30	their	-PRON-	PRP$
cord-262445-54ng7m92	29	31	cell	cell	NN
cord-262445-54ng7m92	29	32	fate	fate	NN
cord-262445-54ng7m92	29	33	decisions	decision	NNS
cord-262445-54ng7m92	29	34	,	,	,
cord-262445-54ng7m92	29	35	whether	whether	IN
cord-262445-54ng7m92	29	36	to	to	TO
cord-262445-54ng7m92	29	37	undergo	undergo	VB
cord-262445-54ng7m92	29	38	self	self	NN
cord-262445-54ng7m92	29	39	-	-	HYPH
cord-262445-54ng7m92	29	40	renewal	renewal	NN
cord-262445-54ng7m92	29	41	or	or	CC
cord-262445-54ng7m92	29	42	commitment	commitment	NN
cord-262445-54ng7m92	29	43	and	and	CC
cord-262445-54ng7m92	29	44	differentiation	differentiation	NN
cord-262445-54ng7m92	29	45	upon	upon	IN
cord-262445-54ng7m92	29	46	cell	cell	NN
cord-262445-54ng7m92	29	47	division	division	NN
cord-262445-54ng7m92	29	48	.	.	.
cord-262445-54ng7m92	30	1	By	by	IN
cord-262445-54ng7m92	30	2	utilizing	utilize	VBG
cord-262445-54ng7m92	30	3	genetic	genetic	JJ
cord-262445-54ng7m92	30	4	and	and	CC
cord-262445-54ng7m92	30	5	pharmacological	pharmacological	JJ
cord-262445-54ng7m92	30	6	tools	tool	NNS
cord-262445-54ng7m92	30	7	,	,	,
cord-262445-54ng7m92	30	8	Sacco	Sacco	NNP
cord-262445-54ng7m92	30	9	and	and	CC
cord-262445-54ng7m92	30	10	co	co	NNS
cord-262445-54ng7m92	30	11	-	-	NNS
cord-262445-54ng7m92	30	12	workers	worker	NNS
cord-262445-54ng7m92	30	13	have	have	VBP
cord-262445-54ng7m92	30	14	identified	identify	VBN
cord-262445-54ng7m92	30	15	STAT3	STAT3	NNP
cord-262445-54ng7m92	30	16	signaling	signal	VBG
cord-262445-54ng7m92	30	17	as	as	IN
cord-262445-54ng7m92	30	18	a	a	DT
cord-262445-54ng7m92	30	19	critical	critical	JJ
cord-262445-54ng7m92	30	20	regulator	regulator	NN
cord-262445-54ng7m92	30	21	of	of	IN
cord-262445-54ng7m92	30	22	MuSC	MuSC	NNP
cord-262445-54ng7m92	30	23	fate	fate	NN
cord-262445-54ng7m92	30	24	decisions	decision	NNS
cord-262445-54ng7m92	30	25	.	.	.
cord-262445-54ng7m92	31	1	The	the	DT
cord-262445-54ng7m92	31	2	inflammatory	inflammatory	JJ
cord-262445-54ng7m92	31	3	response	response	NN
cord-262445-54ng7m92	31	4	of	of	IN
cord-262445-54ng7m92	31	5	injured	injured	JJ
cord-262445-54ng7m92	31	6	skeletal	skeletal	JJ
cord-262445-54ng7m92	31	7	muscle	muscle	NN
cord-262445-54ng7m92	31	8	plays	play	VBZ
cord-262445-54ng7m92	31	9	an	an	DT
cord-262445-54ng7m92	31	10	important	important	JJ
cord-262445-54ng7m92	31	11	and	and	CC
cord-262445-54ng7m92	31	12	critical	critical	JJ
cord-262445-54ng7m92	31	13	role	role	NN
cord-262445-54ng7m92	31	14	in	in	IN
cord-262445-54ng7m92	31	15	muscle	muscle	NN
cord-262445-54ng7m92	31	16	homeostasis	homeostasis	NN
cord-262445-54ng7m92	31	17	and	and	CC
cord-262445-54ng7m92	31	18	regeneration	regeneration	NN
cord-262445-54ng7m92	31	19	and	and	CC
cord-262445-54ng7m92	31	20	consists	consist	VBZ
cord-262445-54ng7m92	31	21	in	in	IN
cord-262445-54ng7m92	31	22	the	the	DT
cord-262445-54ng7m92	31	23	recruitment	recruitment	NN
cord-262445-54ng7m92	31	24	of	of	IN
cord-262445-54ng7m92	31	25	specific	specific	JJ
cord-262445-54ng7m92	31	26	myeloid	myeloid	JJ
cord-262445-54ng7m92	31	27	cell	cell	NN
cord-262445-54ng7m92	31	28	populations	population	NNS
cord-262445-54ng7m92	31	29	within	within	IN
cord-262445-54ng7m92	31	30	the	the	DT
cord-262445-54ng7m92	31	31	injured	injured	JJ
cord-262445-54ng7m92	31	32	area	area	NN
cord-262445-54ng7m92	31	33	.	.	.
cord-262445-54ng7m92	32	1	3	3	CD
cord-262445-54ng7m92	32	2	,	,	,
cord-262445-54ng7m92	32	3	7	7	CD
cord-262445-54ng7m92	32	4	,	,	,
cord-262445-54ng7m92	32	5	8	8	CD
cord-262445-54ng7m92	32	6	Macrophages	macrophage	NNS
cord-262445-54ng7m92	32	7	rapidly	rapidly	RB
cord-262445-54ng7m92	32	8	increases	increase	VBZ
cord-262445-54ng7m92	32	9	within	within	IN
cord-262445-54ng7m92	32	10	24	24	CD
cord-262445-54ng7m92	32	11	hours	hour	NNS
cord-262445-54ng7m92	32	12	after	after	IN
cord-262445-54ng7m92	32	13	injury	injury	NN
cord-262445-54ng7m92	32	14	,	,	,
cord-262445-54ng7m92	32	15	are	be	VBP
cord-262445-54ng7m92	32	16	the	the	DT
cord-262445-54ng7m92	32	17	predominant	predominant	JJ
cord-262445-54ng7m92	32	18	inflammatory	inflammatory	JJ
cord-262445-54ng7m92	32	19	cell	cell	NN
cord-262445-54ng7m92	32	20	type	type	NN
cord-262445-54ng7m92	32	21	within	within	IN
cord-262445-54ng7m92	32	22	the	the	DT
cord-262445-54ng7m92	32	23	injured	injured	JJ
cord-262445-54ng7m92	32	24	area	area	NN
cord-262445-54ng7m92	32	25	,	,	,
cord-262445-54ng7m92	32	26	detectable	detectable	JJ
cord-262445-54ng7m92	32	27	at	at	IN
cord-262445-54ng7m92	32	28	the	the	DT
cord-262445-54ng7m92	32	29	level	level	NN
cord-262445-54ng7m92	32	30	of	of	IN
cord-262445-54ng7m92	32	31	perimysium	perimysium	NN
cord-262445-54ng7m92	32	32	and	and	CC
cord-262445-54ng7m92	32	33	epimysium	epimysium	NN
cord-262445-54ng7m92	32	34	.	.	.
cord-262445-54ng7m92	33	1	Because	because	IN
cord-262445-54ng7m92	33	2	of	of	IN
cord-262445-54ng7m92	33	3	their	-PRON-	PRP$
cord-262445-54ng7m92	33	4	high	high	JJ
cord-262445-54ng7m92	33	5	versatility	versatility	NN
cord-262445-54ng7m92	33	6	and	and	CC
cord-262445-54ng7m92	33	7	their	-PRON-	PRP$
cord-262445-54ng7m92	33	8	impact	impact	NN
cord-262445-54ng7m92	33	9	on	on	IN
cord-262445-54ng7m92	33	10	their	-PRON-	PRP$
cord-262445-54ng7m92	33	11	environment	environment	NN
cord-262445-54ng7m92	33	12	,	,	,
cord-262445-54ng7m92	33	13	they	-PRON-	PRP
cord-262445-54ng7m92	33	14	sustain	sustain	VBP
cord-262445-54ng7m92	33	15	both	both	CC
cord-262445-54ng7m92	33	16	the	the	DT
cord-262445-54ng7m92	33	17	mounting	mount	VBG
cord-262445-54ng7m92	33	18	and	and	CC
cord-262445-54ng7m92	33	19	the	the	DT
cord-262445-54ng7m92	33	20	dampening	dampening	NN
cord-262445-54ng7m92	33	21	of	of	IN
cord-262445-54ng7m92	33	22	the	the	DT
cord-262445-54ng7m92	33	23	inflammatory	inflammatory	JJ
cord-262445-54ng7m92	33	24	response	response	NN
cord-262445-54ng7m92	33	25	.	.	.
cord-262445-54ng7m92	34	1	In	in	IN
cord-262445-54ng7m92	34	2	a	a	DT
cord-262445-54ng7m92	34	3	context	context	NN
cord-262445-54ng7m92	34	4	of	of	IN
cord-262445-54ng7m92	34	5	adult	adult	NN
cord-262445-54ng7m92	34	6	tissue	tissue	NN
cord-262445-54ng7m92	34	7	damage	damage	NN
cord-262445-54ng7m92	34	8	,	,	,
cord-262445-54ng7m92	34	9	that	that	RB
cord-262445-54ng7m92	34	10	is	is	RB
cord-262445-54ng7m92	35	1	post	post	JJ
cord-262445-54ng7m92	35	2	-	-	JJ
cord-262445-54ng7m92	35	3	injury	injury	JJ
cord-262445-54ng7m92	35	4	skeletal	skeletal	JJ
cord-262445-54ng7m92	35	5	muscle	muscle	NN
cord-262445-54ng7m92	35	6	regeneration	regeneration	NN
cord-262445-54ng7m92	35	7	,	,	,
cord-262445-54ng7m92	35	8	accumulating	accumulate	VBG
cord-262445-54ng7m92	35	9	lines	line	NNS
cord-262445-54ng7m92	35	10	of	of	IN
cord-262445-54ng7m92	35	11	evidence	evidence	NN
cord-262445-54ng7m92	35	12	of	of	IN
cord-262445-54ng7m92	35	13	the	the	DT
cord-262445-54ng7m92	35	14	beneficial	beneficial	JJ
cord-262445-54ng7m92	35	15	and	and	CC
cord-262445-54ng7m92	35	16	pleiotropic	pleiotropic	JJ
cord-262445-54ng7m92	35	17	roles	role	NNS
cord-262445-54ng7m92	35	18	of	of	IN
cord-262445-54ng7m92	35	19	macrophages	macrophage	NNS
cord-262445-54ng7m92	35	20	in	in	IN
cord-262445-54ng7m92	35	21	tissue	tissue	NN
cord-262445-54ng7m92	35	22	repair	repair	NN
cord-262445-54ng7m92	35	23	indicate	indicate	VBP
cord-262445-54ng7m92	35	24	that	that	IN
cord-262445-54ng7m92	35	25	inflammation	inflammation	NN
cord-262445-54ng7m92	35	26	should	should	MD
cord-262445-54ng7m92	35	27	not	not	RB
cord-262445-54ng7m92	35	28	be	be	VB
cord-262445-54ng7m92	35	29	considered	consider	VBN
cord-262445-54ng7m92	35	30	as	as	IN
cord-262445-54ng7m92	35	31	a	a	DT
cord-262445-54ng7m92	35	32	bad	bad	JJ
cord-262445-54ng7m92	35	33	or	or	CC
cord-262445-54ng7m92	35	34	detrimental	detrimental	JJ
cord-262445-54ng7m92	35	35	process	process	NN
cord-262445-54ng7m92	35	36	.	.	.
cord-262445-54ng7m92	36	1	Conversely	conversely	RB
cord-262445-54ng7m92	36	2	,	,	,
cord-262445-54ng7m92	36	3	as	as	IN
cord-262445-54ng7m92	36	4	discussed	discuss	VBN
cord-262445-54ng7m92	36	5	by	by	IN
cord-262445-54ng7m92	36	6	Chazaud	Chazaud	NNP
cord-262445-54ng7m92	36	7	,	,	,
cord-262445-54ng7m92	36	8	it	-PRON-	PRP
cord-262445-54ng7m92	36	9	should	should	MD
cord-262445-54ng7m92	36	10	be	be	VB
cord-262445-54ng7m92	36	11	viewed	view	VBN
cord-262445-54ng7m92	36	12	as	as	IN
cord-262445-54ng7m92	36	13	a	a	DT
cord-262445-54ng7m92	36	14	dynamic	dynamic	JJ
cord-262445-54ng7m92	36	15	process	process	NN
cord-262445-54ng7m92	36	16	of	of	IN
cord-262445-54ng7m92	36	17	which	which	WDT
cord-262445-54ng7m92	36	18	sequential	sequential	JJ
cord-262445-54ng7m92	36	19	steps	step	NNS
cord-262445-54ng7m92	36	20	must	must	MD
cord-262445-54ng7m92	36	21	be	be	VB
cord-262445-54ng7m92	36	22	tightly	tightly	RB
cord-262445-54ng7m92	36	23	coordinated	coordinate	VBN
cord-262445-54ng7m92	36	24	in	in	IN
cord-262445-54ng7m92	36	25	space	space	NN
cord-262445-54ng7m92	36	26	and	and	CC
cord-262445-54ng7m92	36	27	time	time	NN
cord-262445-54ng7m92	36	28	to	to	TO
cord-262445-54ng7m92	36	29	be	be	VB
cord-262445-54ng7m92	36	30	fully	fully	RB
cord-262445-54ng7m92	36	31	efficient	efficient	JJ
cord-262445-54ng7m92	36	32	to	to	TO
cord-262445-54ng7m92	36	33	support	support	VB
cord-262445-54ng7m92	36	34	skeletal	skeletal	JJ
cord-262445-54ng7m92	36	35	muscle	muscle	NN
cord-262445-54ng7m92	36	36	regeneration	regeneration	NN
cord-262445-54ng7m92	36	37	.	.	.
cord-262445-54ng7m92	37	1	Based	base	VBN
cord-262445-54ng7m92	37	2	on	on	IN
cord-262445-54ng7m92	37	3	the	the	DT
cord-262445-54ng7m92	37	4	submitted	submit	VBN
cord-262445-54ng7m92	37	5	abstracts	abstract	NNS
cord-262445-54ng7m92	37	6	,	,	,
cord-262445-54ng7m92	37	7	thirty	thirty	CD
cord-262445-54ng7m92	37	8	five	five	CD
cord-262445-54ng7m92	37	9	contributions	contribution	NNS
cord-262445-54ng7m92	37	10	were	be	VBD
cord-262445-54ng7m92	37	11	selected	select	VBN
cord-262445-54ng7m92	37	12	for	for	IN
cord-262445-54ng7m92	37	13	Oral	Oral	NNP
cord-262445-54ng7m92	37	14	Communications	Communications	NNPS
cord-262445-54ng7m92	37	15	that	that	WDT
cord-262445-54ng7m92	37	16	were	be	VBD
cord-262445-54ng7m92	37	17	grouped	group	VBN
cord-262445-54ng7m92	37	18	in	in	IN
cord-262445-54ng7m92	37	19	seven	seven	CD
cord-262445-54ng7m92	37	20	Sessions	session	NNS
cord-262445-54ng7m92	37	21	chaired	chair	VBN
cord-262445-54ng7m92	37	22	by	by	IN
cord-262445-54ng7m92	37	23	young	young	JJ
cord-262445-54ng7m92	37	24	trainees	trainee	NNS
cord-262445-54ng7m92	37	25	:	:	:
cord-262445-54ng7m92	37	26	1	1	CD
cord-262445-54ng7m92	37	27	.	.	.
cord-262445-54ng7m92	38	1	Genetic	genetic	JJ
cord-262445-54ng7m92	38	2	and	and	CC
cord-262445-54ng7m92	38	3	epigenetic	epigenetic	JJ
cord-262445-54ng7m92	38	4	alterations	alteration	NNS
cord-262445-54ng7m92	38	5	in	in	IN
cord-262445-54ng7m92	38	6	muscle	muscle	NN
cord-262445-54ng7m92	38	7	dystrophies	dystrophy	NNS
cord-262445-54ng7m92	38	8	and	and	CC
cord-262445-54ng7m92	38	9	myopathies	myopathy	NNS
cord-262445-54ng7m92	38	10	;	;	:
cord-262445-54ng7m92	38	11	2	2	CD
cord-262445-54ng7m92	38	12	.	.	.
cord-262445-54ng7m92	39	1	Satellite	satellite	NN
cord-262445-54ng7m92	39	2	cells	cell	NNS
cord-262445-54ng7m92	39	3	and	and	CC
cord-262445-54ng7m92	39	4	muscle	muscle	NN
cord-262445-54ng7m92	39	5	regeneration	regeneration	NN
cord-262445-54ng7m92	39	6	in	in	IN
cord-262445-54ng7m92	39	7	healthy	healthy	JJ
cord-262445-54ng7m92	39	8	muscle	muscle	NN
cord-262445-54ng7m92	39	9	and	and	CC
cord-262445-54ng7m92	39	10	in	in	IN
cord-262445-54ng7m92	39	11	diseases	disease	NNS
cord-262445-54ng7m92	39	12	;	;	:
cord-262445-54ng7m92	39	13	3	3	CD
cord-262445-54ng7m92	39	14	.	.	.
cord-262445-54ng7m92	40	1	Biophysics	Biophysics	NNP
cord-262445-54ng7m92	40	2	and	and	CC
cord-262445-54ng7m92	40	3	E	E	NNP
cord-262445-54ng7m92	40	4	-	-	NN
cord-262445-54ng7m92	40	5	C	c	NN
cord-262445-54ng7m92	40	6	coupling	coupling	NN
cord-262445-54ng7m92	40	7	in	in	IN
cord-262445-54ng7m92	40	8	the	the	DT
cord-262445-54ng7m92	40	9	pathophysiology	pathophysiology	NN
cord-262445-54ng7m92	40	10	of	of	IN
cord-262445-54ng7m92	40	11	neuromuscular	neuromuscular	JJ
cord-262445-54ng7m92	40	12	diseases	disease	NNS
cord-262445-54ng7m92	40	13	;	;	:
cord-262445-54ng7m92	40	14	4	4	CD
cord-262445-54ng7m92	40	15	.	.	.
cord-262445-54ng7m92	41	1	Signaling	signal	VBG
cord-262445-54ng7m92	41	2	in	in	IN
cord-262445-54ng7m92	41	3	muscle	muscle	NN
cord-262445-54ng7m92	41	4	growth	growth	NN
cord-262445-54ng7m92	41	5	,	,	,
cord-262445-54ng7m92	41	6	homeostasis	homeostasis	NN
cord-262445-54ng7m92	41	7	and	and	CC
cord-262445-54ng7m92	41	8	disease	disease	NN
cord-262445-54ng7m92	41	9	;	;	:
cord-262445-54ng7m92	41	10	5	5	CD
cord-262445-54ng7m92	41	11	.	.	.
cord-262445-54ng7m92	42	1	Metabolic	metabolic	JJ
cord-262445-54ng7m92	42	2	alterations	alteration	NNS
cord-262445-54ng7m92	42	3	and	and	CC
cord-262445-54ng7m92	42	4	muscle	muscle	NN
cord-262445-54ng7m92	42	5	diseases	disease	NNS
cord-262445-54ng7m92	42	6	;	;	:
cord-262445-54ng7m92	42	7	6	6	CD
cord-262445-54ng7m92	42	8	.	.	.
cord-262445-54ng7m92	43	1	Muscle	muscle	NN
cord-262445-54ng7m92	43	2	fibrosis	fibrosis	NN
cord-262445-54ng7m92	43	3	,	,	,
cord-262445-54ng7m92	43	4	sarcopenia	sarcopenia	NN
cord-262445-54ng7m92	43	5	and	and	CC
cord-262445-54ng7m92	43	6	cachexia	cachexia	NN
cord-262445-54ng7m92	43	7	;	;	:
cord-262445-54ng7m92	43	8	7	7	CD
cord-262445-54ng7m92	43	9	.	.	.
cord-262445-54ng7m92	44	1	Therapeutic	therapeutic	JJ
cord-262445-54ng7m92	44	2	approaches	approach	NNS
cord-262445-54ng7m92	44	3	for	for	IN
cord-262445-54ng7m92	44	4	muscle	muscle	NN
cord-262445-54ng7m92	44	5	diseases	disease	NNS
cord-262445-54ng7m92	44	6	.	.	.
cord-262445-54ng7m92	45	1	Twenty	twenty	CD
cord-262445-54ng7m92	45	2	seven	seven	CD
cord-262445-54ng7m92	45	3	poster	poster	NN
cord-262445-54ng7m92	45	4	presentations	presentation	NNS
cord-262445-54ng7m92	45	5	,	,	,
cord-262445-54ng7m92	45	6	always	always	RB
cord-262445-54ng7m92	45	7	on	on	IN
cord-262445-54ng7m92	45	8	display	display	NN
cord-262445-54ng7m92	45	9	during	during	IN
cord-262445-54ng7m92	45	10	the	the	DT
cord-262445-54ng7m92	45	11	entire	entire	JJ
cord-262445-54ng7m92	45	12	Meeting	meeting	NN
cord-262445-54ng7m92	45	13	,	,	,
cord-262445-54ng7m92	45	14	completed	complete	VBD
cord-262445-54ng7m92	45	15	the	the	DT
cord-262445-54ng7m92	45	16	program	program	NN
cord-262445-54ng7m92	45	17	.	.	.
cord-262445-54ng7m92	46	1	Presentations	presentation	NNS
cord-262445-54ng7m92	46	2	provided	provide	VBD
cord-262445-54ng7m92	46	3	breakthroughs	breakthrough	NNS
cord-262445-54ng7m92	46	4	in	in	IN
cord-262445-54ng7m92	46	5	the	the	DT
cord-262445-54ng7m92	46	6	muscle	muscle	NN
cord-262445-54ng7m92	46	7	field	field	NN
cord-262445-54ng7m92	46	8	,	,	,
cord-262445-54ng7m92	46	9	at	at	IN
cord-262445-54ng7m92	46	10	a	a	DT
cord-262445-54ng7m92	46	11	fundamental	fundamental	JJ
cord-262445-54ng7m92	46	12	and	and	CC
cord-262445-54ng7m92	46	13	therapeutic	therapeutic	JJ
cord-262445-54ng7m92	46	14	level	level	NN
cord-262445-54ng7m92	46	15	,	,	,
cord-262445-54ng7m92	46	16	and	and	CC
cord-262445-54ng7m92	46	17	stimulated	stimulate	VBD
cord-262445-54ng7m92	46	18	lively	lively	JJ
cord-262445-54ng7m92	46	19	and	and	CC
cord-262445-54ng7m92	46	20	exciting	exciting	JJ
cord-262445-54ng7m92	46	21	scientific	scientific	JJ
cord-262445-54ng7m92	46	22	discussions	discussion	NNS
cord-262445-54ng7m92	46	23	,	,	,
cord-262445-54ng7m92	46	24	which	which	WDT
cord-262445-54ng7m92	46	25	were	be	VBD
cord-262445-54ng7m92	46	26	continued	continue	VBN
cord-262445-54ng7m92	46	27	through	through	IN
cord-262445-54ng7m92	46	28	spontaneous	spontaneous	JJ
cord-262445-54ng7m92	46	29	gatherings	gathering	NNS
cord-262445-54ng7m92	46	30	of	of	IN
cord-262445-54ng7m92	46	31	several	several	JJ
cord-262445-54ng7m92	46	32	groups	group	NNS
cord-262445-54ng7m92	46	33	at	at	IN
cord-262445-54ng7m92	46	34	coffee	coffee	NN
cord-262445-54ng7m92	46	35	breaks	break	NNS
cord-262445-54ng7m92	46	36	and	and	CC
cord-262445-54ng7m92	46	37	after	after	IN
cord-262445-54ng7m92	46	38	lunch	lunch	NN
cord-262445-54ng7m92	46	39	and	and	CC
cord-262445-54ng7m92	46	40	dinner	dinner	NN
cord-262445-54ng7m92	46	41	leading	lead	VBG
cord-262445-54ng7m92	46	42	to	to	IN
cord-262445-54ng7m92	46	43	the	the	DT
cord-262445-54ng7m92	46	44	development	development	NN
cord-262445-54ng7m92	46	45	of	of	IN
cord-262445-54ng7m92	46	46	new	new	JJ
cord-262445-54ng7m92	46	47	collaborations	collaboration	NNS
cord-262445-54ng7m92	46	48	.	.	.
cord-262445-54ng7m92	47	1	On	on	IN
cord-262445-54ng7m92	47	2	the	the	DT
cord-262445-54ng7m92	47	3	first	first	JJ
cord-262445-54ng7m92	47	4	evening	evening	NN
cord-262445-54ng7m92	47	5	of	of	IN
cord-262445-54ng7m92	47	6	the	the	DT
cord-262445-54ng7m92	47	7	meeting	meeting	NN
cord-262445-54ng7m92	47	8	,	,	,
cord-262445-54ng7m92	47	9	there	there	EX
cord-262445-54ng7m92	47	10	were	be	VBD
cord-262445-54ng7m92	47	11	three	three	CD
cord-262445-54ng7m92	47	12	Roundtable	Roundtable	NNP
cord-262445-54ng7m92	47	13	Discussions	Discussions	NNPS
cord-262445-54ng7m92	47	14	organized	organize	VBN
cord-262445-54ng7m92	47	15	by	by	IN
cord-262445-54ng7m92	47	16	young	young	JJ
cord-262445-54ng7m92	47	17	trainees	trainee	NNS
cord-262445-54ng7m92	47	18	and	and	CC
cord-262445-54ng7m92	47	19	moderated	moderate	VBN
cord-262445-54ng7m92	47	20	by	by	IN
cord-262445-54ng7m92	47	21	the	the	DT
cord-262445-54ng7m92	47	22	invited	invite	VBN
cord-262445-54ng7m92	47	23	speakers	speaker	NNS
cord-262445-54ng7m92	47	24	and	and	CC
cord-262445-54ng7m92	47	25	selected	select	VBN
cord-262445-54ng7m92	47	26	members	member	NNS
cord-262445-54ng7m92	47	27	of	of	IN
cord-262445-54ng7m92	47	28	the	the	DT
cord-262445-54ng7m92	47	29	IIM	IIM	NNP
cord-262445-54ng7m92	47	30	.	.	.
cord-262445-54ng7m92	48	1	The	the	DT
cord-262445-54ng7m92	48	2	participants	participant	NNS
cord-262445-54ng7m92	48	3	discussed	discuss	VBD
cord-262445-54ng7m92	48	4	about	about	IN
cord-262445-54ng7m92	48	5	new	new	JJ
cord-262445-54ng7m92	48	6	ideas	idea	NNS
cord-262445-54ng7m92	48	7	concerning	concern	VBG
cord-262445-54ng7m92	48	8	muscle	muscle	NN
cord-262445-54ng7m92	48	9	development	development	NN
cord-262445-54ng7m92	48	10	&	&	CC
cord-262445-54ng7m92	48	11	regeneration	regeneration	NN
cord-262445-54ng7m92	48	12	;	;	:
cord-262445-54ng7m92	48	13	inflammation	inflammation	NN
cord-262445-54ng7m92	48	14	,	,	,
cord-262445-54ng7m92	48	15	metabolism	metabolism	NN
cord-262445-54ng7m92	48	16	;	;	,
cord-262445-54ng7m92	48	17	oxidative	oxidative	JJ
cord-262445-54ng7m92	48	18	muscle	muscle	NN
cord-262445-54ng7m92	48	19	damage	damage	NN
cord-262445-54ng7m92	48	20	.	.	.
cord-262445-54ng7m92	49	1	The	the	DT
cord-262445-54ng7m92	49	2	roundtables	roundtable	NNS
cord-262445-54ng7m92	49	3	allowed	allow	VBD
cord-262445-54ng7m92	49	4	to	to	TO
cord-262445-54ng7m92	49	5	discuss	discuss	VB
cord-262445-54ng7m92	49	6	muscle	muscle	NN
cord-262445-54ng7m92	49	7	research	research	NN
cord-262445-54ng7m92	49	8	in	in	IN
cord-262445-54ng7m92	49	9	an	an	DT
cord-262445-54ng7m92	49	10	informal	informal	JJ
cord-262445-54ng7m92	49	11	way	way	NN
cord-262445-54ng7m92	49	12	,	,	,
cord-262445-54ng7m92	49	13	over	over	IN
cord-262445-54ng7m92	49	14	food	food	NN
cord-262445-54ng7m92	49	15	and	and	CC
cord-262445-54ng7m92	49	16	drinks	drink	NNS
cord-262445-54ng7m92	49	17	provided	provide	VBN
cord-262445-54ng7m92	49	18	by	by	IN
cord-262445-54ng7m92	49	19	local	local	JJ
cord-262445-54ng7m92	49	20	producers	producer	NNS
cord-262445-54ng7m92	49	21	.	.	.
cord-262445-54ng7m92	50	1	On	on	IN
cord-262445-54ng7m92	50	2	the	the	DT
cord-262445-54ng7m92	50	3	second	second	JJ
cord-262445-54ng7m92	50	4	evening	evening	NN
cord-262445-54ng7m92	50	5	of	of	IN
cord-262445-54ng7m92	50	6	the	the	DT
cord-262445-54ng7m92	50	7	meeting	meeting	NN
cord-262445-54ng7m92	50	8	,	,	,
cord-262445-54ng7m92	50	9	guided	guide	VBN
cord-262445-54ng7m92	50	10	tours	tour	NNS
cord-262445-54ng7m92	50	11	were	be	VBD
cord-262445-54ng7m92	50	12	organized	organize	VBN
cord-262445-54ng7m92	50	13	to	to	IN
cord-262445-54ng7m92	50	14	the	the	DT
cord-262445-54ng7m92	50	15	historic	historic	JJ
cord-262445-54ng7m92	50	16	section	section	NN
cord-262445-54ng7m92	50	17	of	of	IN
cord-262445-54ng7m92	50	18	the	the	DT
cord-262445-54ng7m92	50	19	city	city	NN
cord-262445-54ng7m92	50	20	of	of	IN
cord-262445-54ng7m92	50	21	Montefalco	Montefalco	NNP
cord-262445-54ng7m92	50	22	and	and	CC
cord-262445-54ng7m92	50	23	the	the	DT
cord-262445-54ng7m92	50	24	"	"	``
cord-262445-54ng7m92	50	25	Cantina	Cantina	NNP
cord-262445-54ng7m92	50	26	Lungarotti	Lungarotti	NNP
cord-262445-54ng7m92	50	27	"	"	''
cord-262445-54ng7m92	50	28	winery	winery	NN
cord-262445-54ng7m92	50	29	,	,	,
cord-262445-54ng7m92	50	30	terminating	terminate	VBG
cord-262445-54ng7m92	50	31	with	with	IN
cord-262445-54ng7m92	50	32	a	a	DT
cord-262445-54ng7m92	50	33	wine	wine	NN
cord-262445-54ng7m92	50	34	tasting	tasting	NN
cord-262445-54ng7m92	50	35	and	and	CC
cord-262445-54ng7m92	50	36	banquet	banquet	NN
cord-262445-54ng7m92	50	37	dinner	dinner	NN
cord-262445-54ng7m92	50	38	.	.	.
cord-262445-54ng7m92	51	1	Finally	finally	RB
cord-262445-54ng7m92	51	2	,	,	,
cord-262445-54ng7m92	51	3	an	an	DT
cord-262445-54ng7m92	51	4	Award	Award	NNP
cord-262445-54ng7m92	51	5	Ceremony	Ceremony	NNP
cord-262445-54ng7m92	51	6	was	be	VBD
cord-262445-54ng7m92	51	7	held	hold	VBN
cord-262445-54ng7m92	51	8	on	on	IN
cord-262445-54ng7m92	51	9	the	the	DT
cord-262445-54ng7m92	51	10	last	last	JJ
cord-262445-54ng7m92	51	11	evening	evening	NN
cord-262445-54ng7m92	51	12	of	of	IN
cord-262445-54ng7m92	51	13	the	the	DT
cord-262445-54ng7m92	51	14	meeting	meeting	NN
cord-262445-54ng7m92	51	15	to	to	TO
cord-262445-54ng7m92	51	16	congratulate	congratulate	VB
cord-262445-54ng7m92	51	17	Marco	Marco	NNP
cord-262445-54ng7m92	51	18	Rosina	Rosina	NNP
cord-262445-54ng7m92	51	19	,	,	,
cord-262445-54ng7m92	51	20	Martina	Martina	NNP
cord-262445-54ng7m92	51	21	Sandonà	Sandonà	NNP
cord-262445-54ng7m92	51	22	and	and	CC
cord-262445-54ng7m92	51	23	Valentina	Valentina	NNP
cord-262445-54ng7m92	51	24	Taglietti	Taglietti	NNP
cord-262445-54ng7m92	51	25	,	,	,
cord-262445-54ng7m92	51	26	winners	winner	NNS
cord-262445-54ng7m92	51	27	of	of	IN
cord-262445-54ng7m92	51	28	prices	price	NNS
cord-262445-54ng7m92	51	29	for	for	IN
cord-262445-54ng7m92	51	30	best	good	JJS
cord-262445-54ng7m92	51	31	Poster	poster	NN
cord-262445-54ng7m92	51	32	,	,	,
cord-262445-54ng7m92	51	33	Oral	oral	JJ
cord-262445-54ng7m92	51	34	and	and	CC
cord-262445-54ng7m92	51	35	Active	Active	NNP
cord-262445-54ng7m92	51	36	Participation	Participation	NNP
cord-262445-54ng7m92	51	37	awards	award	NNS
cord-262445-54ng7m92	51	38	,	,	,
cord-262445-54ng7m92	51	39	respectively	respectively	RB
cord-262445-54ng7m92	51	40	,	,	,
cord-262445-54ng7m92	51	41	selected	select	VBN
cord-262445-54ng7m92	51	42	by	by	IN
cord-262445-54ng7m92	51	43	an	an	DT
cord-262445-54ng7m92	51	44	international	international	JJ
cord-262445-54ng7m92	51	45	panel	panel	NN
cord-262445-54ng7m92	51	46	composed	compose	VBN
cord-262445-54ng7m92	51	47	by	by	IN
cord-262445-54ng7m92	51	48	the	the	DT
cord-262445-54ng7m92	51	49	Invited	Invited	NNP
cord-262445-54ng7m92	51	50	Speakers	Speakers	NNP
cord-262445-54ng7m92	51	51	and	and	CC
cord-262445-54ng7m92	51	52	key	key	JJ
cord-262445-54ng7m92	51	53	members	member	NNS
cord-262445-54ng7m92	51	54	of	of	IN
cord-262445-54ng7m92	51	55	the	the	DT
cord-262445-54ng7m92	51	56	IIM	IIM	NNP
cord-262445-54ng7m92	51	57	.	.	.
cord-262445-54ng7m92	52	1	For	for	IN
cord-262445-54ng7m92	52	2	the	the	DT
cord-262445-54ng7m92	52	3	first	first	JJ
cord-262445-54ng7m92	52	4	time	time	NN
cord-262445-54ng7m92	52	5	,	,	,
cord-262445-54ng7m92	52	6	the	the	DT
cord-262445-54ng7m92	52	7	IIM	IIM	NNP
cord-262445-54ng7m92	52	8	Meeting	Meeting	NNP
cord-262445-54ng7m92	52	9	was	be	VBD
cord-262445-54ng7m92	52	10	joined	join	VBN
cord-262445-54ng7m92	52	11	with	with	IN
cord-262445-54ng7m92	52	12	a	a	DT
cord-262445-54ng7m92	52	13	High	High	NNP
cord-262445-54ng7m92	52	14	Training	training	NN
cord-262445-54ng7m92	52	15	Course	course	NN
cord-262445-54ng7m92	52	16	on	on	IN
cord-262445-54ng7m92	52	17	"	"	``
cord-262445-54ng7m92	52	18	Advanced	Advanced	NNP
cord-262445-54ng7m92	52	19	Myology	Myology	NNP
cord-262445-54ng7m92	52	20	"	"	''
cord-262445-54ng7m92	52	21	,	,	,
cord-262445-54ng7m92	52	22	organized	organize	VBN
cord-262445-54ng7m92	52	23	together	together	RB
cord-262445-54ng7m92	52	24	with	with	IN
cord-262445-54ng7m92	52	25	the	the	DT
cord-262445-54ng7m92	52	26	University	University	NNP
cord-262445-54ng7m92	52	27	of	of	IN
cord-262445-54ng7m92	52	28	Perugia	Perugia	NNP
cord-262445-54ng7m92	52	29	and	and	CC
cord-262445-54ng7m92	52	30	reserved	reserve	VBN
cord-262445-54ng7m92	52	31	to	to	IN
cord-262445-54ng7m92	52	32	young	young	JJ
cord-262445-54ng7m92	52	33	trainees	trainee	NNS
cord-262445-54ng7m92	52	34	.	.	.
cord-262445-54ng7m92	53	1	The	the	DT
cord-262445-54ng7m92	53	2	highlight	highlight	NN
cord-262445-54ng7m92	53	3	of	of	IN
cord-262445-54ng7m92	53	4	the	the	DT
cord-262445-54ng7m92	53	5	Course	course	NN
cord-262445-54ng7m92	53	6	was	be	VBD
cord-262445-54ng7m92	53	7	on	on	IN
cord-262445-54ng7m92	53	8	October	October	NNP
cord-262445-54ng7m92	53	9	20th	20th	NN
cord-262445-54ng7m92	53	10	with	with	IN
cord-262445-54ng7m92	53	11	lectures	lecture	NNS
cord-262445-54ng7m92	53	12	on	on	IN
cord-262445-54ng7m92	53	13	muscle	muscle	NN
cord-262445-54ng7m92	53	14	development	development	NN
cord-262445-54ng7m92	53	15	and	and	CC
cord-262445-54ng7m92	53	16	response	response	NN
cord-262445-54ng7m92	53	17	to	to	TO
cord-262445-54ng7m92	53	18	exercise	exercise	VB
cord-262445-54ng7m92	53	19	by	by	IN
cord-262445-54ng7m92	53	20	international	international	JJ
cord-262445-54ng7m92	53	21	speakers	speaker	NNS
cord-262445-54ng7m92	53	22	taking	take	VBG
cord-262445-54ng7m92	53	23	place	place	NN
cord-262445-54ng7m92	53	24	in	in	IN
cord-262445-54ng7m92	53	25	Palazzo	Palazzo	NNP
cord-262445-54ng7m92	53	26	Bernabei	Bernabei	NNP
cord-262445-54ng7m92	53	27	,	,	,
cord-262445-54ng7m92	53	28	a	a	DT
cord-262445-54ng7m92	53	29	beautiful	beautiful	JJ
cord-262445-54ng7m92	53	30	1400	1400	CD
cord-262445-54ng7m92	53	31	building	building	NN
cord-262445-54ng7m92	53	32	located	locate	VBN
cord-262445-54ng7m92	53	33	in	in	IN
cord-262445-54ng7m92	53	34	front	front	NN
cord-262445-54ng7m92	53	35	of	of	IN
cord-262445-54ng7m92	53	36	the	the	DT
cord-262445-54ng7m92	53	37	St.	St.	NNP
cord-262445-54ng7m92	53	38	Francis	Francis	NNP
cord-262445-54ng7m92	53	39	Basilica	Basilica	NNP
cord-262445-54ng7m92	53	40	.	.	.
cord-262445-54ng7m92	54	1	The	the	DT
cord-262445-54ng7m92	54	2	meeting	meeting	NN
cord-262445-54ng7m92	54	3	and	and	CC
cord-262445-54ng7m92	54	4	the	the	DT
cord-262445-54ng7m92	54	5	course	course	NN
cord-262445-54ng7m92	54	6	were	be	VBD
cord-262445-54ng7m92	54	7	very	very	RB
cord-262445-54ng7m92	54	8	successful	successful	JJ
cord-262445-54ng7m92	54	9	and	and	CC
cord-262445-54ng7m92	54	10	instrumental	instrumental	JJ
cord-262445-54ng7m92	54	11	to	to	TO
cord-262445-54ng7m92	54	12	foster	foster	VB
cord-262445-54ng7m92	54	13	new	new	JJ
cord-262445-54ng7m92	54	14	ideas	idea	NNS
cord-262445-54ng7m92	54	15	and	and	CC
cord-262445-54ng7m92	54	16	facilitate	facilitate	VB
cord-262445-54ng7m92	54	17	collaborations	collaboration	NNS
cord-262445-54ng7m92	54	18	among	among	IN
cord-262445-54ng7m92	54	19	the	the	DT
cord-262445-54ng7m92	54	20	different	different	JJ
cord-262445-54ng7m92	54	21	stakeholders	stakeholder	NNS
cord-262445-54ng7m92	54	22	.	.	.
cord-262445-54ng7m92	55	1	Taken	take	VBN
cord-262445-54ng7m92	55	2	together	together	RB
cord-262445-54ng7m92	55	3	,	,	,
cord-262445-54ng7m92	55	4	the	the	DT
cord-262445-54ng7m92	55	5	attendees	attendee	NNS
cord-262445-54ng7m92	55	6	of	of	IN
cord-262445-54ng7m92	55	7	the	the	DT
cord-262445-54ng7m92	55	8	IIM	IIM	NNP
cord-262445-54ng7m92	55	9	and	and	CC
cord-262445-54ng7m92	55	10	of	of	IN
cord-262445-54ng7m92	55	11	the	the	DT
cord-262445-54ng7m92	55	12	PaduaMuscleDays	paduamuscleday	NNS
cord-262445-54ng7m92	55	13	(	(	-LRB-
cord-262445-54ng7m92	55	14	PMDs	PMDs	NNPS
cord-262445-54ng7m92	55	15	,	,	,
cord-262445-54ng7m92	55	16	a	a	DT
cord-262445-54ng7m92	55	17	meeting	meeting	NN
cord-262445-54ng7m92	55	18	more	more	RBR
cord-262445-54ng7m92	55	19	oriented	oriented	JJ
cord-262445-54ng7m92	55	20	to	to	IN
cord-262445-54ng7m92	55	21	advanced	advanced	JJ
cord-262445-54ng7m92	55	22	Translational	Translational	NNP
cord-262445-54ng7m92	55	23	Myology	Myology	NNP
cord-262445-54ng7m92	55	24	)	)	-RRB-
cord-262445-54ng7m92	55	25	and	and	CC
cord-262445-54ng7m92	55	26	the	the	DT
cord-262445-54ng7m92	55	27	authors	author	NNS
cord-262445-54ng7m92	55	28	of	of	IN
cord-262445-54ng7m92	55	29	papers	paper	NNS
cord-262445-54ng7m92	55	30	e	e	NN
cord-262445-54ng7m92	55	31	-	-	HYPH
cord-262445-54ng7m92	55	32	printed	print	VBN
cord-262445-54ng7m92	55	33	in	in	IN
cord-262445-54ng7m92	55	34	the	the	DT
cord-262445-54ng7m92	55	35	European	European	NNP
cord-262445-54ng7m92	55	36	Journal	Journal	NNP
cord-262445-54ng7m92	55	37	of	of	IN
cord-262445-54ng7m92	55	38	Translational	Translational	NNP
cord-262445-54ng7m92	55	39	Myology	Myology	NNP
cord-262445-54ng7m92	55	40	(	(	-LRB-
cord-262445-54ng7m92	55	41	EJTM	EJTM	NNP
cord-262445-54ng7m92	55	42	)	)	-RRB-
cord-262445-54ng7m92	55	43	are	be	VBP
cord-262445-54ng7m92	55	44	a	a	DT
cord-262445-54ng7m92	55	45	substantial	substantial	JJ
cord-262445-54ng7m92	55	46	part	part	NN
cord-262445-54ng7m92	55	47	of	of	IN
cord-262445-54ng7m92	55	48	the	the	DT
cord-262445-54ng7m92	55	49	international	international	JJ
cord-262445-54ng7m92	55	50	community	community	NN
cord-262445-54ng7m92	55	51	of	of	IN
cord-262445-54ng7m92	55	52	Myologists	Myologists	NNP
cord-262445-54ng7m92	55	53	.	.	.
cord-262445-54ng7m92	56	1	9,10,11	9,10,11	CD
cord-262445-54ng7m92	57	1	Here	here	RB
cord-262445-54ng7m92	57	2	,	,	,
cord-262445-54ng7m92	57	3	the	the	DT
cord-262445-54ng7m92	57	4	Muscle	Muscle	NNP
cord-262445-54ng7m92	57	5	as	as	IN
cord-262445-54ng7m92	57	6	an	an	DT
cord-262445-54ng7m92	57	7	endocrine	endocrine	JJ
cord-262445-54ng7m92	57	8	organ	organ	NN
cord-262445-54ng7m92	57	9	Skeletal	skeletal	JJ
cord-262445-54ng7m92	57	10	muscle	muscle	NN
cord-262445-54ng7m92	57	11	works	work	VBZ
cord-262445-54ng7m92	57	12	as	as	IN
cord-262445-54ng7m92	57	13	an	an	DT
cord-262445-54ng7m92	57	14	endocrine	endocrine	JJ
cord-262445-54ng7m92	57	15	organ	organ	NN
cord-262445-54ng7m92	57	16	with	with	IN
cord-262445-54ng7m92	57	17	the	the	DT
cord-262445-54ng7m92	57	18	capacity	capacity	NN
cord-262445-54ng7m92	57	19	to	to	TO
cord-262445-54ng7m92	57	20	produce	produce	VB
cord-262445-54ng7m92	57	21	hundreds	hundred	NNS
cord-262445-54ng7m92	57	22	of	of	IN
cord-262445-54ng7m92	57	23	myokines	myokine	NNS
cord-262445-54ng7m92	57	24	.	.	.
cord-262445-54ng7m92	58	1	This	this	DT
cord-262445-54ng7m92	58	2	finding	finding	NN
cord-262445-54ng7m92	58	3	provides	provide	VBZ
cord-262445-54ng7m92	58	4	a	a	DT
cord-262445-54ng7m92	58	5	conceptual	conceptual	JJ
cord-262445-54ng7m92	58	6	basis	basis	NN
cord-262445-54ng7m92	58	7	for	for	IN
cord-262445-54ng7m92	58	8	understanding	understand	VBG
cord-262445-54ng7m92	58	9	how	how	WRB
cord-262445-54ng7m92	58	10	muscles	muscle	NNS
cord-262445-54ng7m92	58	11	communicate	communicate	VBP
cord-262445-54ng7m92	58	12	with	with	IN
cord-262445-54ng7m92	58	13	other	other	JJ
cord-262445-54ng7m92	58	14	organs	organ	NNS
cord-262445-54ng7m92	58	15	such	such	JJ
cord-262445-54ng7m92	58	16	as	as	IN
cord-262445-54ng7m92	58	17	adipose	adipose	JJ
cord-262445-54ng7m92	58	18	tissue	tissue	NN
cord-262445-54ng7m92	58	19	,	,	,
cord-262445-54ng7m92	58	20	liver	liver	NN
cord-262445-54ng7m92	58	21	,	,	,
cord-262445-54ng7m92	58	22	pancreas	pancrea	NNS
cord-262445-54ng7m92	58	23	,	,	,
cord-262445-54ng7m92	58	24	bones	bone	NNS
cord-262445-54ng7m92	58	25	,	,	,
cord-262445-54ng7m92	58	26	and	and	CC
cord-262445-54ng7m92	58	27	brain	brain	NN
cord-262445-54ng7m92	58	28	.	.	.
cord-262445-54ng7m92	59	1	Some	some	DT
cord-262445-54ng7m92	59	2	myokines	myokine	NNS
cord-262445-54ng7m92	59	3	are	be	VBP
cord-262445-54ng7m92	59	4	thought	think	VBN
cord-262445-54ng7m92	59	5	to	to	TO
cord-262445-54ng7m92	59	6	induce	induce	VB
cord-262445-54ng7m92	59	7	anti	anti	JJ
cord-262445-54ng7m92	59	8	-	-	JJ
cord-262445-54ng7m92	59	9	inflammatory	inflammatory	JJ
cord-262445-54ng7m92	59	10	responses	response	NNS
cord-262445-54ng7m92	59	11	with	with	IN
cord-262445-54ng7m92	59	12	each	each	DT
cord-262445-54ng7m92	59	13	bout	bout	NN
cord-262445-54ng7m92	59	14	of	of	IN
cord-262445-54ng7m92	59	15	exercise	exercise	NN
cord-262445-54ng7m92	59	16	and	and	CC
cord-262445-54ng7m92	59	17	other	other	JJ
cord-262445-54ng7m92	59	18	mediate	mediate	VB
cord-262445-54ng7m92	59	19	long	long	JJ
cord-262445-54ng7m92	59	20	-	-	HYPH
cord-262445-54ng7m92	59	21	term	term	NN
cord-262445-54ng7m92	59	22	exercise	exercise	NN
cord-262445-54ng7m92	59	23	-	-	HYPH
cord-262445-54ng7m92	59	24	induced	induce	VBN
cord-262445-54ng7m92	59	25	improvements	improvement	NNS
cord-262445-54ng7m92	59	26	in	in	IN
cord-262445-54ng7m92	59	27	cardiovascular	cardiovascular	JJ
cord-262445-54ng7m92	59	28	risk	risk	NN
cord-262445-54ng7m92	59	29	factors	factor	NNS
cord-262445-54ng7m92	59	30	,	,	,
cord-262445-54ng7m92	59	31	having	have	VBG
cord-262445-54ng7m92	59	32	an	an	DT
cord-262445-54ng7m92	59	33	indirect	indirect	JJ
cord-262445-54ng7m92	59	34	anti	anti	JJ
cord-262445-54ng7m92	59	35	-	-	JJ
cord-262445-54ng7m92	59	36	inflammatory	inflammatory	JJ
cord-262445-54ng7m92	59	37	effect	effect	NN
cord-262445-54ng7m92	59	38	.	.	.
cord-262445-54ng7m92	60	1	Myokines	Myokines	NNP
cord-262445-54ng7m92	60	2	also	also	RB
cord-262445-54ng7m92	60	3	mediate	mediate	VBP
cord-262445-54ng7m92	60	4	anticancer	anticancer	JJ
cord-262445-54ng7m92	60	5	effects	effect	NNS
cord-262445-54ng7m92	60	6	and	and	CC
cord-262445-54ng7m92	60	7	contribute	contribute	VBP
cord-262445-54ng7m92	60	8	to	to	TO
cord-262445-54ng7m92	60	9	regulate	regulate	VB
cord-262445-54ng7m92	60	10	metabolism	metabolism	NN
cord-262445-54ng7m92	60	11	and	and	CC
cord-262445-54ng7m92	60	12	cognitive	cognitive	JJ
cord-262445-54ng7m92	60	13	function	function	NN
cord-262445-54ng7m92	60	14	.	.	.
cord-262445-54ng7m92	61	1	The	the	DT
cord-262445-54ng7m92	61	2	myokine	myokine	NN
cord-262445-54ng7m92	61	3	IL-6	IL-6	NNP
cord-262445-54ng7m92	61	4	is	be	VBZ
cord-262445-54ng7m92	61	5	released	release	VBN
cord-262445-54ng7m92	61	6	into	into	IN
cord-262445-54ng7m92	61	7	the	the	DT
cord-262445-54ng7m92	61	8	blood	blood	NN
cord-262445-54ng7m92	61	9	during	during	IN
cord-262445-54ng7m92	61	10	exercise	exercise	NN
cord-262445-54ng7m92	61	11	and	and	CC
cord-262445-54ng7m92	61	12	it	-PRON-	PRP
cord-262445-54ng7m92	61	13	has	have	VBZ
cord-262445-54ng7m92	61	14	been	be	VBN
cord-262445-54ng7m92	61	15	shown	show	VBN
cord-262445-54ng7m92	61	16	that	that	IN
cord-262445-54ng7m92	61	17	IL-6	IL-6	NNP
cord-262445-54ng7m92	61	18	has	have	VBZ
cord-262445-54ng7m92	61	19	multiple	multiple	JJ
cord-262445-54ng7m92	61	20	immunologic	immunologic	JJ
cord-262445-54ng7m92	61	21	and	and	CC
cord-262445-54ng7m92	61	22	metabolic	metabolic	JJ
cord-262445-54ng7m92	61	23	effects	effect	NNS
cord-262445-54ng7m92	61	24	.	.	.
cord-262445-54ng7m92	62	1	Recent	recent	JJ
cord-262445-54ng7m92	62	2	advances	advance	NNS
cord-262445-54ng7m92	62	3	regarding	regard	VBG
cord-262445-54ng7m92	62	4	the	the	DT
cord-262445-54ng7m92	62	5	physiology	physiology	NN
cord-262445-54ng7m92	62	6	of	of	IN
cord-262445-54ng7m92	62	7	IL-6	IL-6	NNP
cord-262445-54ng7m92	62	8	will	will	MD
cord-262445-54ng7m92	62	9	be	be	VB
cord-262445-54ng7m92	62	10	discussed	discuss	VBN
cord-262445-54ng7m92	62	11	.	.	.
cord-262445-54ng7m92	63	1	Human	human	JJ
cord-262445-54ng7m92	63	2	studies	study	NNS
cord-262445-54ng7m92	63	3	show	show	VBP
cord-262445-54ng7m92	63	4	that	that	IN
cord-262445-54ng7m92	63	5	IL-6	IL-6	NNP
cord-262445-54ng7m92	63	6	infusion	infusion	NN
cord-262445-54ng7m92	63	7	delays	delay	NNS
cord-262445-54ng7m92	63	8	gastric	gastric	JJ
cord-262445-54ng7m92	63	9	emptying	emptying	NN
cord-262445-54ng7m92	63	10	,	,	,
cord-262445-54ng7m92	63	11	reduces	reduce	VBZ
cord-262445-54ng7m92	63	12	postprandial	postprandial	JJ
cord-262445-54ng7m92	63	13	glucose	glucose	NN
cord-262445-54ng7m92	63	14	concentrations	concentration	NNS
cord-262445-54ng7m92	63	15	and	and	CC
cord-262445-54ng7m92	63	16	reduces	reduce	VBZ
cord-262445-54ng7m92	63	17	insulin	insulin	NN
cord-262445-54ng7m92	63	18	secretion	secretion	NN
cord-262445-54ng7m92	63	19	,	,	,
cord-262445-54ng7m92	63	20	whereas	whereas	IN
cord-262445-54ng7m92	63	21	experimental	experimental	JJ
cord-262445-54ng7m92	63	22	studies	study	NNS
cord-262445-54ng7m92	63	23	suggest	suggest	VBP
cord-262445-54ng7m92	63	24	a	a	DT
cord-262445-54ng7m92	63	25	role	role	NN
cord-262445-54ng7m92	63	26	for	for	IN
cord-262445-54ng7m92	63	27	IL-6	IL-6	NNP
cord-262445-54ng7m92	63	28	in	in	IN
cord-262445-54ng7m92	63	29	appetite	appetite	NN
cord-262445-54ng7m92	63	30	regulation	regulation	NN
cord-262445-54ng7m92	63	31	.	.	.
cord-262445-54ng7m92	64	1	Evidence	evidence	NN
cord-262445-54ng7m92	64	2	is	be	VBZ
cord-262445-54ng7m92	64	3	also	also	RB
cord-262445-54ng7m92	64	4	accumulating	accumulate	VBG
cord-262445-54ng7m92	64	5	for	for	IN
cord-262445-54ng7m92	64	6	a	a	DT
cord-262445-54ng7m92	64	7	central	central	JJ
cord-262445-54ng7m92	64	8	role	role	NN
cord-262445-54ng7m92	64	9	of	of	IN
cord-262445-54ng7m92	64	10	IL-6	IL-6	NNP
cord-262445-54ng7m92	64	11	in	in	IN
cord-262445-54ng7m92	64	12	training	training	NN
cord-262445-54ng7m92	64	13	-	-	HYPH
cord-262445-54ng7m92	64	14	induced	induce	VBN
cord-262445-54ng7m92	64	15	loss	loss	NN
cord-262445-54ng7m92	64	16	of	of	IN
cord-262445-54ng7m92	64	17	visceral	visceral	JJ
cord-262445-54ng7m92	64	18	adipose	adipose	JJ
cord-262445-54ng7m92	64	19	tissue	tissue	NN
cord-262445-54ng7m92	64	20	mass	mass	NN
cord-262445-54ng7m92	64	21	in	in	IN
cord-262445-54ng7m92	64	22	humans	human	NNS
cord-262445-54ng7m92	64	23	.	.	.
cord-262445-54ng7m92	65	1	Moreover	moreover	RB
cord-262445-54ng7m92	65	2	,	,	,
cord-262445-54ng7m92	65	3	recent	recent	JJ
cord-262445-54ng7m92	65	4	experimental	experimental	JJ
cord-262445-54ng7m92	65	5	studies	study	NNS
cord-262445-54ng7m92	65	6	in	in	IN
cord-262445-54ng7m92	65	7	mice	mouse	NNS
cord-262445-54ng7m92	65	8	show	show	VBP
cord-262445-54ng7m92	65	9	that	that	IN
cord-262445-54ng7m92	65	10	voluntary	voluntary	JJ
cord-262445-54ng7m92	65	11	exercise	exercise	NN
cord-262445-54ng7m92	65	12	suppresses	suppress	VBZ
cord-262445-54ng7m92	65	13	tumor	tumor	NN
cord-262445-54ng7m92	65	14	growth	growth	NN
cord-262445-54ng7m92	65	15	through	through	IN
cord-262445-54ng7m92	65	16	epinephrine	epinephrine	NN
cord-262445-54ng7m92	65	17	-	-	:
cord-262445-54ng7m92	65	18	and	and	CC
cord-262445-54ng7m92	65	19	IL-6-dependent	il-6-dependent	CD
cord-262445-54ng7m92	65	20	mobilization	mobilization	NN
cord-262445-54ng7m92	65	21	and	and	CC
cord-262445-54ng7m92	65	22	redistribution	redistribution	NN
cord-262445-54ng7m92	65	23	of	of	IN
cord-262445-54ng7m92	65	24	cytotoxic	cytotoxic	JJ
cord-262445-54ng7m92	65	25	NK	NK	NNP
cord-262445-54ng7m92	65	26	cells	cell	NNS
cord-262445-54ng7m92	65	27	.	.	.
cord-262445-54ng7m92	66	1	It	-PRON-	PRP
cord-262445-54ng7m92	66	2	has	have	VBZ
cord-262445-54ng7m92	66	3	been	be	VBN
cord-262445-54ng7m92	66	4	known	know	VBN
cord-262445-54ng7m92	66	5	for	for	IN
cord-262445-54ng7m92	66	6	a	a	DT
cord-262445-54ng7m92	66	7	while	while	NN
cord-262445-54ng7m92	66	8	that	that	WDT
cord-262445-54ng7m92	66	9	IL-6	IL-6	NNP
cord-262445-54ng7m92	66	10	is	be	VBZ
cord-262445-54ng7m92	66	11	a	a	DT
cord-262445-54ng7m92	66	12	pleiotropic	pleiotropic	JJ
cord-262445-54ng7m92	66	13	molecule	molecule	NN
cord-262445-54ng7m92	66	14	,	,	,
cord-262445-54ng7m92	66	15	however	however	RB
cord-262445-54ng7m92	66	16	,	,	,
cord-262445-54ng7m92	66	17	recent	recent	JJ
cord-262445-54ng7m92	66	18	advances	advance	NNS
cord-262445-54ng7m92	66	19	suggest	suggest	VBP
cord-262445-54ng7m92	66	20	that	that	IN
cord-262445-54ng7m92	66	21	the	the	DT
cord-262445-54ng7m92	66	22	physiological	physiological	JJ
cord-262445-54ng7m92	66	23	roles	role	NNS
cord-262445-54ng7m92	66	24	of	of	IN
cord-262445-54ng7m92	66	25	IL-6	IL-6	NNP
cord-262445-54ng7m92	66	26	involve	involve	VBP
cord-262445-54ng7m92	66	27	multiple	multiple	JJ
cord-262445-54ng7m92	66	28	aspects	aspect	NNS
cord-262445-54ng7m92	66	29	of	of	IN
cord-262445-54ng7m92	66	30	metabolism	metabolism	NN
cord-262445-54ng7m92	66	31	as	as	RB
cord-262445-54ng7m92	66	32	well	well	RB
cord-262445-54ng7m92	66	33	as	as	IN
cord-262445-54ng7m92	66	34	a	a	DT
cord-262445-54ng7m92	66	35	role	role	NN
cord-262445-54ng7m92	66	36	in	in	IN
cord-262445-54ng7m92	66	37	tumor	tumor	NN
cord-262445-54ng7m92	66	38	defense	defense	NN
cord-262445-54ng7m92	66	39	.	.	.
cord-262445-54ng7m92	67	1	Bente	Bente	NNP
cord-262445-54ng7m92	67	2	Klarlund	Klarlund	NNP
cord-262445-54ng7m92	67	3	Pedersen	Pedersen	NNP
cord-262445-54ng7m92	67	4	,	,	,
cord-262445-54ng7m92	67	5	MD	MD	NNP
cord-262445-54ng7m92	67	6	MDSc	MDSc	NNP
cord-262445-54ng7m92	67	7	,	,	,
cord-262445-54ng7m92	67	8	is	be	VBZ
cord-262445-54ng7m92	67	9	Professor	Professor	NNP
cord-262445-54ng7m92	67	10	of	of	IN
cord-262445-54ng7m92	67	11	Integrative	Integrative	NNP
cord-262445-54ng7m92	67	12	Medicine	Medicine	NNP
cord-262445-54ng7m92	67	13	and	and	CC
cord-262445-54ng7m92	67	14	a	a	DT
cord-262445-54ng7m92	67	15	specialist	specialist	NN
cord-262445-54ng7m92	67	16	in	in	IN
cord-262445-54ng7m92	67	17	infectious	infectious	JJ
cord-262445-54ng7m92	67	18	diseases	disease	NNS
cord-262445-54ng7m92	67	19	and	and	CC
cord-262445-54ng7m92	67	20	internal	internal	JJ
cord-262445-54ng7m92	67	21	medicine	medicine	NN
cord-262445-54ng7m92	67	22	.	.	.
cord-262445-54ng7m92	68	1	She	-PRON-	PRP
cord-262445-54ng7m92	68	2	is	be	VBZ
cord-262445-54ng7m92	68	3	the	the	DT
cord-262445-54ng7m92	68	4	Director	Director	NNP
cord-262445-54ng7m92	68	5	of	of	IN
cord-262445-54ng7m92	68	6	the	the	DT
cord-262445-54ng7m92	68	7	Centre	Centre	NNP
cord-262445-54ng7m92	68	8	of	of	IN
cord-262445-54ng7m92	68	9	Inflammation	Inflammation	NNP
cord-262445-54ng7m92	68	10	and	and	CC
cord-262445-54ng7m92	68	11	Metabolism	Metabolism	NNP
cord-262445-54ng7m92	68	12	(	(	-LRB-
cord-262445-54ng7m92	68	13	CIM	CIM	NNP
cord-262445-54ng7m92	68	14	)	)	-RRB-
cord-262445-54ng7m92	68	15	and	and	CC
cord-262445-54ng7m92	68	16	the	the	DT
cord-262445-54ng7m92	68	17	Centre	Centre	NNP
cord-262445-54ng7m92	68	18	for	for	IN
cord-262445-54ng7m92	68	19	Physical	Physical	NNP
cord-262445-54ng7m92	68	20	Activity	Activity	NNP
cord-262445-54ng7m92	68	21	Research	Research	NNP
cord-262445-54ng7m92	68	22	(	(	-LRB-
cord-262445-54ng7m92	68	23	CFAS	CFAS	NNP
cord-262445-54ng7m92	68	24	)	)	-RRB-
cord-262445-54ng7m92	68	25	funded	fund	VBN
cord-262445-54ng7m92	68	26	by	by	IN
cord-262445-54ng7m92	68	27	TrygFonden	TrygFonden	NNP
cord-262445-54ng7m92	68	28	.	.	.
cord-262445-54ng7m92	69	1	CIM	CIM	NNP
cord-262445-54ng7m92	69	2	and	and	CC
cord-262445-54ng7m92	69	3	CFAS	CFAS	NNP
cord-262445-54ng7m92	69	4	count	count	VBP
cord-262445-54ng7m92	69	5	17	17	CD
cord-262445-54ng7m92	69	6	senior	senior	JJ
cord-262445-54ng7m92	69	7	researchers	researcher	NNS
cord-262445-54ng7m92	69	8	/	/	SYM
cord-262445-54ng7m92	69	9	postdocs	postdoc	NNS
cord-262445-54ng7m92	69	10	,	,	,
cord-262445-54ng7m92	69	11	17	17	CD
cord-262445-54ng7m92	69	12	PhD	phd	NN
cord-262445-54ng7m92	69	13	students	student	NNS
cord-262445-54ng7m92	69	14	,	,	,
cord-262445-54ng7m92	69	15	21	21	CD
cord-262445-54ng7m92	69	16	other	other	JJ
cord-262445-54ng7m92	69	17	academic	academic	JJ
cord-262445-54ng7m92	69	18	and	and	CC
cord-262445-54ng7m92	69	19	technical	technical	JJ
cord-262445-54ng7m92	69	20	personnel	personnel	NNS
cord-262445-54ng7m92	69	21	,	,	,
cord-262445-54ng7m92	69	22	5	5	CD
cord-262445-54ng7m92	69	23	pre	pre	JJ
cord-262445-54ng7m92	69	24	-	-	JJ
cord-262445-54ng7m92	69	25	graduate	graduate	JJ
cord-262445-54ng7m92	69	26	students	student	NNS
cord-262445-54ng7m92	69	27	and	and	CC
cord-262445-54ng7m92	69	28	an	an	DT
cord-262445-54ng7m92	69	29	administration	administration	NN
cord-262445-54ng7m92	69	30	of	of	IN
cord-262445-54ng7m92	69	31	5	5	CD
cord-262445-54ng7m92	69	32	persons	person	NNS
cord-262445-54ng7m92	69	33	(	(	-LRB-
cord-262445-54ng7m92	69	34	http://aktivsundhed.dk	http://aktivsundhed.dk	NNP
cord-262445-54ng7m92	69	35	)	)	-RRB-
cord-262445-54ng7m92	69	36	.	.	.
cord-262445-54ng7m92	70	1	She	-PRON-	PRP
cord-262445-54ng7m92	70	2	has	have	VBZ
cord-262445-54ng7m92	70	3	supervised	supervise	VBN
cord-262445-54ng7m92	70	4	47	47	CD
cord-262445-54ng7m92	70	5	PhD	phd	NN
cord-262445-54ng7m92	70	6	projects	project	NNS
cord-262445-54ng7m92	70	7	and	and	CC
cord-262445-54ng7m92	70	8	been	be	VBN
cord-262445-54ng7m92	70	9	a	a	DT
cord-262445-54ng7m92	70	10	mentor	mentor	NN
cord-262445-54ng7m92	70	11	of	of	IN
cord-262445-54ng7m92	70	12	5	5	CD
cord-262445-54ng7m92	70	13	doctoral	doctoral	PDT
cord-262445-54ng7m92	70	14	these	these	DT
cord-262445-54ng7m92	70	15	s	s	NNS
cord-262445-54ng7m92	70	16	.	.	.
cord-262445-54ng7m92	71	1	The	the	DT
cord-262445-54ng7m92	71	2	research	research	NN
cord-262445-54ng7m92	71	3	group	group	NN
cord-262445-54ng7m92	71	4	has	have	VBZ
cord-262445-54ng7m92	71	5	identified	identify	VBN
cord-262445-54ng7m92	71	6	skeletal	skeletal	JJ
cord-262445-54ng7m92	71	7	muscle	muscle	NN
cord-262445-54ng7m92	71	8	as	as	IN
cord-262445-54ng7m92	71	9	an	an	DT
cord-262445-54ng7m92	71	10	endocrine	endocrine	JJ
cord-262445-54ng7m92	71	11	organ	organ	NN
cord-262445-54ng7m92	71	12	that	that	WDT
cord-262445-54ng7m92	71	13	produces	produce	VBZ
cord-262445-54ng7m92	71	14	and	and	CC
cord-262445-54ng7m92	71	15	releases	release	VBZ
cord-262445-54ng7m92	71	16	so	so	RB
cord-262445-54ng7m92	71	17	-	-	HYPH
cord-262445-54ng7m92	71	18	called	call	VBN
cord-262445-54ng7m92	71	19	"	"	``
cord-262445-54ng7m92	71	20	myokines	myokine	NNS
cord-262445-54ng7m92	71	21	"	"	''
cord-262445-54ng7m92	71	22	.	.	.
cord-262445-54ng7m92	72	1	The	the	DT
cord-262445-54ng7m92	72	2	identification	identification	NN
cord-262445-54ng7m92	72	3	of	of	IN
cord-262445-54ng7m92	72	4	myokines	myokines	NNP
cord-262445-54ng7m92	72	5	provides	provide	VBZ
cord-262445-54ng7m92	72	6	a	a	DT
cord-262445-54ng7m92	72	7	conceptual	conceptual	JJ
cord-262445-54ng7m92	72	8	basis	basis	NN
cord-262445-54ng7m92	72	9	for	for	IN
cord-262445-54ng7m92	72	10	understanding	understand	VBG
cord-262445-54ng7m92	72	11	how	how	WRB
cord-262445-54ng7m92	72	12	muscles	muscle	NNS
cord-262445-54ng7m92	72	13	communicate	communicate	VBP
cord-262445-54ng7m92	72	14	with	with	IN
cord-262445-54ng7m92	72	15	other	other	JJ
cord-262445-54ng7m92	72	16	organs	organ	NNS
cord-262445-54ng7m92	72	17	.	.	.
cord-262445-54ng7m92	73	1	Through	through	IN
cord-262445-54ng7m92	73	2	translational	translational	JJ
cord-262445-54ng7m92	73	3	research	research	NN
cord-262445-54ng7m92	73	4	,	,	,
cord-262445-54ng7m92	73	5	the	the	DT
cord-262445-54ng7m92	73	6	aim	aim	NN
cord-262445-54ng7m92	73	7	is	be	VBZ
cord-262445-54ng7m92	73	8	to	to	TO
cord-262445-54ng7m92	73	9	develop	develop	VB
cord-262445-54ng7m92	73	10	targeted	target	VBN
cord-262445-54ng7m92	73	11	exercise	exercise	NN
cord-262445-54ng7m92	73	12	training	training	NN
cord-262445-54ng7m92	73	13	regimes	regime	NNS
cord-262445-54ng7m92	73	14	for	for	IN
cord-262445-54ng7m92	73	15	specific	specific	JJ
cord-262445-54ng7m92	73	16	disease	disease	NN
cord-262445-54ng7m92	73	17	groups	group	NNS
cord-262445-54ng7m92	73	18	by	by	IN
cord-262445-54ng7m92	73	19	applying	apply	VBG
cord-262445-54ng7m92	73	20	a	a	DT
cord-262445-54ng7m92	73	21	translational	translational	JJ
cord-262445-54ng7m92	73	22	strategy	strategy	NN
cord-262445-54ng7m92	73	23	:	:	:
cord-262445-54ng7m92	73	24	"	"	``
cord-262445-54ng7m92	73	25	from	from	IN
cord-262445-54ng7m92	73	26	bedside	bedside	NN
cord-262445-54ng7m92	73	27	to	to	TO
cord-262445-54ng7m92	73	28	bench	bench	VB
cord-262445-54ng7m92	73	29	and	and	CC
cord-262445-54ng7m92	73	30	back	back	NN
cord-262445-54ng7m92	73	31	"	"	''
cord-262445-54ng7m92	73	32	.	.	.
cord-262445-54ng7m92	74	1	BKP	BKP	NNP
cord-262445-54ng7m92	74	2	has	have	VBZ
cord-262445-54ng7m92	74	3	had	have	VBN
cord-262445-54ng7m92	74	4	many	many	JJ
cord-262445-54ng7m92	74	5	positions	position	NNS
cord-262445-54ng7m92	74	6	of	of	IN
cord-262445-54ng7m92	74	7	trust	trust	NN
cord-262445-54ng7m92	74	8	and	and	CC
cord-262445-54ng7m92	74	9	is	be	VBZ
cord-262445-54ng7m92	74	10	a	a	DT
cord-262445-54ng7m92	74	11	member	member	NN
cord-262445-54ng7m92	74	12	of	of	IN
cord-262445-54ng7m92	74	13	the	the	DT
cord-262445-54ng7m92	74	14	Royal	Royal	NNP
cord-262445-54ng7m92	74	15	Danish	Danish	NNP
cord-262445-54ng7m92	74	16	Academy	Academy	NNP
cord-262445-54ng7m92	74	17	of	of	IN
cord-262445-54ng7m92	74	18	Sciences	Sciences	NNPS
cord-262445-54ng7m92	74	19	and	and	CC
cord-262445-54ng7m92	74	20	Letters	Letters	NNPS
cord-262445-54ng7m92	74	21	.	.	.
cord-262445-54ng7m92	75	1	BKP	BKP	NNP
cord-262445-54ng7m92	75	2	has	have	VBZ
cord-262445-54ng7m92	75	3	more	more	JJR
cord-262445-54ng7m92	75	4	than	than	IN
cord-262445-54ng7m92	75	5	650	650	CD
cord-262445-54ng7m92	75	6	scientific	scientific	JJ
cord-262445-54ng7m92	75	7	publications	publication	NNS
cord-262445-54ng7m92	75	8	,	,	,
cord-262445-54ng7m92	75	9	>	>	XX
cord-262445-54ng7m92	76	1	41.000	41.000	CD
cord-262445-54ng7m92	76	2	citation	citation	NN
cord-262445-54ng7m92	76	3	and	and	CC
cord-262445-54ng7m92	76	4	her	-PRON-	PRP$
cord-262445-54ng7m92	76	5	"	"	``
cord-262445-54ng7m92	76	6	H"-index	H"-index	NNP
cord-262445-54ng7m92	77	1	is	be	VBZ
cord-262445-54ng7m92	77	2	107	107	CD
cord-262445-54ng7m92	78	1	(	(	-LRB-
cord-262445-54ng7m92	78	2	Web	web	NN
cord-262445-54ng7m92	78	3	of	of	IN
cord-262445-54ng7m92	78	4	Science	Science	NNP
cord-262445-54ng7m92	78	5	)	)	-RRB-
cord-262445-54ng7m92	78	6	.	.	.
cord-262445-54ng7m92	79	1	Inflammation	inflammation	NN
cord-262445-54ng7m92	79	2	after	after	IN
cord-262445-54ng7m92	79	3	a	a	DT
cord-262445-54ng7m92	79	4	tissue	tissue	NN
cord-262445-54ng7m92	79	5	damage	damage	NN
cord-262445-54ng7m92	79	6	encompasses	encompass	VBZ
cord-262445-54ng7m92	79	7	several	several	JJ
cord-262445-54ng7m92	79	8	sequential	sequential	JJ
cord-262445-54ng7m92	79	9	phases	phase	NNS
cord-262445-54ng7m92	79	10	including	include	VBG
cord-262445-54ng7m92	79	11	:	:	:
cord-262445-54ng7m92	79	12	(	(	-LRB-
cord-262445-54ng7m92	79	13	1	1	LS
cord-262445-54ng7m92	79	14	)	)	-RRB-
cord-262445-54ng7m92	79	15	the	the	DT
cord-262445-54ng7m92	79	16	mounting	mounting	NN
cord-262445-54ng7m92	79	17	of	of	IN
cord-262445-54ng7m92	79	18	the	the	DT
cord-262445-54ng7m92	79	19	inflammatory	inflammatory	JJ
cord-262445-54ng7m92	79	20	response	response	NN
cord-262445-54ng7m92	79	21	,	,	,
cord-262445-54ng7m92	79	22	characterized	characterize	VBN
cord-262445-54ng7m92	79	23	by	by	IN
cord-262445-54ng7m92	79	24	the	the	DT
cord-262445-54ng7m92	79	25	infiltration	infiltration	NN
cord-262445-54ng7m92	79	26	of	of	IN
cord-262445-54ng7m92	79	27	immune	immune	JJ
cord-262445-54ng7m92	79	28	cells	cell	NNS
cord-262445-54ng7m92	79	29	to	to	IN
cord-262445-54ng7m92	79	30	the	the	DT
cord-262445-54ng7m92	79	31	site	site	NN
cord-262445-54ng7m92	79	32	of	of	IN
cord-262445-54ng7m92	79	33	injury	injury	NN
cord-262445-54ng7m92	79	34	and	and	CC
cord-262445-54ng7m92	79	35	the	the	DT
cord-262445-54ng7m92	79	36	release	release	NN
cord-262445-54ng7m92	79	37	of	of	IN
cord-262445-54ng7m92	79	38	proinflammatory	proinflammatory	JJ
cord-262445-54ng7m92	79	39	effectors	effector	NNS
cord-262445-54ng7m92	79	40	;	;	:
cord-262445-54ng7m92	79	41	(	(	-LRB-
cord-262445-54ng7m92	79	42	2	2	LS
cord-262445-54ng7m92	79	43	)	)	-RRB-
cord-262445-54ng7m92	79	44	the	the	DT
cord-262445-54ng7m92	79	45	resolution	resolution	NN
cord-262445-54ng7m92	79	46	of	of	IN
cord-262445-54ng7m92	79	47	inflammation	inflammation	NN
cord-262445-54ng7m92	79	48	,	,	,
cord-262445-54ng7m92	79	49	characterized	characterize	VBN
cord-262445-54ng7m92	79	50	by	by	IN
cord-262445-54ng7m92	79	51	a	a	DT
cord-262445-54ng7m92	79	52	shift	shift	NN
cord-262445-54ng7m92	79	53	from	from	IN
cord-262445-54ng7m92	79	54	a	a	DT
cord-262445-54ng7m92	79	55	proinflammatory	proinflammatory	JJ
cord-262445-54ng7m92	79	56	environment	environment	NN
cord-262445-54ng7m92	79	57	to	to	IN
cord-262445-54ng7m92	79	58	the	the	DT
cord-262445-54ng7m92	79	59	establishment	establishment	NN
cord-262445-54ng7m92	79	60	of	of	IN
cord-262445-54ng7m92	79	61	the	the	DT
cord-262445-54ng7m92	79	62	anti	anti	JJ
cord-262445-54ng7m92	79	63	-	-	JJ
cord-262445-54ng7m92	79	64	inflammatory	inflammatory	JJ
cord-262445-54ng7m92	79	65	phase	phase	NN
cord-262445-54ng7m92	79	66	of	of	IN
cord-262445-54ng7m92	79	67	inflammation	inflammation	NN
cord-262445-54ng7m92	79	68	;	;	:
cord-262445-54ng7m92	79	69	and	and	CC
cord-262445-54ng7m92	79	70	(	(	-LRB-
cord-262445-54ng7m92	79	71	3	3	LS
cord-262445-54ng7m92	79	72	)	)	-RRB-
cord-262445-54ng7m92	79	73	tissue	tissue	NN
cord-262445-54ng7m92	79	74	repair	repair	NN
cord-262445-54ng7m92	79	75	/	/	SYM
cord-262445-54ng7m92	79	76	regeneration	regeneration	NN
cord-262445-54ng7m92	79	77	including	include	VBG
cord-262445-54ng7m92	79	78	angiogenesis	angiogenesis	NN
cord-262445-54ng7m92	79	79	,	,	,
cord-262445-54ng7m92	79	80	matrix	matrix	NN
cord-262445-54ng7m92	79	81	remodeling	remodeling	NN
cord-262445-54ng7m92	79	82	and	and	CC
cord-262445-54ng7m92	79	83	return	return	VB
cord-262445-54ng7m92	79	84	to	to	IN
cord-262445-54ng7m92	79	85	homeostasis	homeostasis	NN
cord-262445-54ng7m92	79	86	.	.	.
cord-262445-54ng7m92	80	1	Almost	almost	RB
cord-262445-54ng7m92	80	2	all	all	DT
cord-262445-54ng7m92	80	3	immune	immune	JJ
cord-262445-54ng7m92	80	4	cell	cell	NN
cord-262445-54ng7m92	80	5	types	type	NNS
cord-262445-54ng7m92	80	6	participate	participate	VBP
cord-262445-54ng7m92	80	7	in	in	IN
cord-262445-54ng7m92	80	8	this	this	DT
cord-262445-54ng7m92	80	9	inflammatory	inflammatory	JJ
cord-262445-54ng7m92	80	10	process	process	NN
cord-262445-54ng7m92	80	11	.	.	.
cord-262445-54ng7m92	81	1	However	however	RB
cord-262445-54ng7m92	81	2	,	,	,
cord-262445-54ng7m92	81	3	macrophages	macrophage	NNS
cord-262445-54ng7m92	81	4	are	be	VBP
cord-262445-54ng7m92	81	5	present	present	JJ
cord-262445-54ng7m92	81	6	in	in	IN
cord-262445-54ng7m92	81	7	high	high	JJ
cord-262445-54ng7m92	81	8	number	number	NN
cord-262445-54ng7m92	81	9	and	and	CC
cord-262445-54ng7m92	81	10	during	during	IN
cord-262445-54ng7m92	81	11	all	all	PDT
cord-262445-54ng7m92	81	12	the	the	DT
cord-262445-54ng7m92	81	13	sequences	sequence	NNS
cord-262445-54ng7m92	81	14	of	of	IN
cord-262445-54ng7m92	81	15	the	the	DT
cord-262445-54ng7m92	81	16	inflammatory	inflammatory	JJ
cord-262445-54ng7m92	81	17	response	response	NN
cord-262445-54ng7m92	81	18	.	.	.
cord-262445-54ng7m92	82	1	Because	because	IN
cord-262445-54ng7m92	82	2	of	of	IN
cord-262445-54ng7m92	82	3	their	-PRON-	PRP$
cord-262445-54ng7m92	82	4	high	high	JJ
cord-262445-54ng7m92	82	5	versatility	versatility	NN
cord-262445-54ng7m92	82	6	and	and	CC
cord-262445-54ng7m92	82	7	their	-PRON-	PRP$
cord-262445-54ng7m92	82	8	impact	impact	NN
cord-262445-54ng7m92	82	9	on	on	IN
cord-262445-54ng7m92	82	10	their	-PRON-	PRP$
cord-262445-54ng7m92	82	11	environment	environment	NN
cord-262445-54ng7m92	82	12	,	,	,
cord-262445-54ng7m92	82	13	they	-PRON-	PRP
cord-262445-54ng7m92	82	14	sustain	sustain	VBP
cord-262445-54ng7m92	82	15	both	both	CC
cord-262445-54ng7m92	82	16	the	the	DT
cord-262445-54ng7m92	82	17	mounting	mount	VBG
cord-262445-54ng7m92	82	18	and	and	CC
cord-262445-54ng7m92	82	19	the	the	DT
cord-262445-54ng7m92	82	20	dampening	dampening	NN
cord-262445-54ng7m92	82	21	of	of	IN
cord-262445-54ng7m92	82	22	the	the	DT
cord-262445-54ng7m92	82	23	inflammatory	inflammatory	JJ
cord-262445-54ng7m92	82	24	response	response	NN
cord-262445-54ng7m92	82	25	.	.	.
cord-262445-54ng7m92	83	1	In	in	IN
cord-262445-54ng7m92	83	2	a	a	DT
cord-262445-54ng7m92	83	3	context	context	NN
cord-262445-54ng7m92	83	4	of	of	IN
cord-262445-54ng7m92	83	5	adult	adult	NN
cord-262445-54ng7m92	83	6	tissue	tissue	NN
cord-262445-54ng7m92	83	7	damage	damage	NN
cord-262445-54ng7m92	83	8	,	,	,
cord-262445-54ng7m92	83	9	that	that	RB
cord-262445-54ng7m92	83	10	is	is	RB
cord-262445-54ng7m92	84	1	post	post	JJ
cord-262445-54ng7m92	84	2	-	-	JJ
cord-262445-54ng7m92	84	3	injury	injury	JJ
cord-262445-54ng7m92	84	4	skeletal	skeletal	JJ
cord-262445-54ng7m92	84	5	muscle	muscle	NN
cord-262445-54ng7m92	84	6	regeneration	regeneration	NN
cord-262445-54ng7m92	84	7	,	,	,
cord-262445-54ng7m92	84	8	accumulating	accumulate	VBG
cord-262445-54ng7m92	84	9	lines	line	NNS
cord-262445-54ng7m92	84	10	of	of	IN
cord-262445-54ng7m92	84	11	evidence	evidence	NN
cord-262445-54ng7m92	84	12	of	of	IN
cord-262445-54ng7m92	84	13	the	the	DT
cord-262445-54ng7m92	84	14	beneficial	beneficial	JJ
cord-262445-54ng7m92	84	15	and	and	CC
cord-262445-54ng7m92	84	16	pleiotropic	pleiotropic	JJ
cord-262445-54ng7m92	84	17	roles	role	NNS
cord-262445-54ng7m92	84	18	of	of	IN
cord-262445-54ng7m92	84	19	macrophages	macrophage	NNS
cord-262445-54ng7m92	84	20	in	in	IN
cord-262445-54ng7m92	84	21	tissue	tissue	NN
cord-262445-54ng7m92	84	22	repair	repair	NN
cord-262445-54ng7m92	84	23	indicate	indicate	VBP
cord-262445-54ng7m92	84	24	that	that	IN
cord-262445-54ng7m92	84	25	inflammation	inflammation	NN
cord-262445-54ng7m92	84	26	should	should	MD
cord-262445-54ng7m92	84	27	not	not	RB
cord-262445-54ng7m92	84	28	be	be	VB
cord-262445-54ng7m92	84	29	considered	consider	VBN
cord-262445-54ng7m92	84	30	as	as	IN
cord-262445-54ng7m92	84	31	a	a	DT
cord-262445-54ng7m92	84	32	bad	bad	JJ
cord-262445-54ng7m92	84	33	or	or	CC
cord-262445-54ng7m92	84	34	detrimental	detrimental	JJ
cord-262445-54ng7m92	84	35	process	process	NN
cord-262445-54ng7m92	84	36	.	.	.
cord-262445-54ng7m92	85	1	Conversely	conversely	RB
cord-262445-54ng7m92	85	2	,	,	,
cord-262445-54ng7m92	85	3	it	-PRON-	PRP
cord-262445-54ng7m92	85	4	should	should	MD
cord-262445-54ng7m92	85	5	be	be	VB
cord-262445-54ng7m92	85	6	viewed	view	VBN
cord-262445-54ng7m92	85	7	as	as	IN
cord-262445-54ng7m92	85	8	a	a	DT
cord-262445-54ng7m92	85	9	dynamic	dynamic	JJ
cord-262445-54ng7m92	85	10	process	process	NN
cord-262445-54ng7m92	85	11	of	of	IN
cord-262445-54ng7m92	85	12	which	which	WDT
cord-262445-54ng7m92	85	13	sequential	sequential	JJ
cord-262445-54ng7m92	85	14	steps	step	NNS
cord-262445-54ng7m92	85	15	must	must	MD
cord-262445-54ng7m92	85	16	be	be	VB
cord-262445-54ng7m92	85	17	tightly	tightly	RB
cord-262445-54ng7m92	85	18	coordinated	coordinate	VBN
cord-262445-54ng7m92	85	19	in	in	IN
cord-262445-54ng7m92	85	20	space	space	NN
cord-262445-54ng7m92	85	21	and	and	CC
cord-262445-54ng7m92	85	22	time	time	NN
cord-262445-54ng7m92	85	23	to	to	TO
cord-262445-54ng7m92	85	24	be	be	VB
cord-262445-54ng7m92	85	25	fully	fully	RB
cord-262445-54ng7m92	85	26	efficient	efficient	JJ
cord-262445-54ng7m92	85	27	to	to	TO
cord-262445-54ng7m92	85	28	support	support	VB
cord-262445-54ng7m92	85	29	skeletal	skeletal	JJ
cord-262445-54ng7m92	85	30	muscle	muscle	NN
cord-262445-54ng7m92	85	31	regeneration	regeneration	NN
cord-262445-54ng7m92	85	32	.	.	.
cord-262445-54ng7m92	86	1	Particularly	particularly	RB
cord-262445-54ng7m92	86	2	,	,	,
cord-262445-54ng7m92	86	3	macrophages	macrophage	NNS
cord-262445-54ng7m92	86	4	exert	exert	VBP
cord-262445-54ng7m92	86	5	specific	specific	JJ
cord-262445-54ng7m92	86	6	actions	action	NNS
cord-262445-54ng7m92	86	7	on	on	IN
cord-262445-54ng7m92	86	8	muscle	muscle	NN
cord-262445-54ng7m92	86	9	stem	stem	NN
cord-262445-54ng7m92	86	10	cells	cell	NNS
cord-262445-54ng7m92	86	11	during	during	IN
cord-262445-54ng7m92	86	12	the	the	DT
cord-262445-54ng7m92	86	13	sequential	sequential	JJ
cord-262445-54ng7m92	86	14	phases	phase	NNS
cord-262445-54ng7m92	86	15	of	of	IN
cord-262445-54ng7m92	86	16	myogenesis	myogenesis	NN
cord-262445-54ng7m92	86	17	,	,	,
cord-262445-54ng7m92	86	18	as	as	IN
cord-262445-54ng7m92	86	19	they	-PRON-	PRP
cord-262445-54ng7m92	86	20	first	first	RB
cord-262445-54ng7m92	86	21	support	support	VBP
cord-262445-54ng7m92	86	22	the	the	DT
cord-262445-54ng7m92	86	23	expansion	expansion	NN
cord-262445-54ng7m92	86	24	of	of	IN
cord-262445-54ng7m92	86	25	muscle	muscle	NN
cord-262445-54ng7m92	86	26	stem	stem	NN
cord-262445-54ng7m92	86	27	cells	cell	NNS
cord-262445-54ng7m92	86	28	,	,	,
cord-262445-54ng7m92	86	29	then	then	RB
cord-262445-54ng7m92	86	30	their	-PRON-	PRP$
cord-262445-54ng7m92	86	31	differentiation	differentiation	NN
cord-262445-54ng7m92	86	32	and	and	CC
cord-262445-54ng7m92	86	33	fusion	fusion	NN
cord-262445-54ng7m92	86	34	into	into	IN
cord-262445-54ng7m92	86	35	new	new	JJ
cord-262445-54ng7m92	86	36	functional	functional	JJ
cord-262445-54ng7m92	86	37	myofibers	myofiber	NNS
cord-262445-54ng7m92	86	38	.	.	.
cord-262445-54ng7m92	87	1	Conversely	conversely	RB
cord-262445-54ng7m92	87	2	,	,	,
cord-262445-54ng7m92	87	3	in	in	IN
cord-262445-54ng7m92	87	4	chronic	chronic	JJ
cord-262445-54ng7m92	87	5	degenerative	degenerative	JJ
cord-262445-54ng7m92	87	6	muscle	muscle	NN
cord-262445-54ng7m92	87	7	diseases	disease	NNS
cord-262445-54ng7m92	87	8	,	,	,
cord-262445-54ng7m92	87	9	such	such	JJ
cord-262445-54ng7m92	87	10	as	as	IN
cord-262445-54ng7m92	87	11	in	in	IN
cord-262445-54ng7m92	87	12	muscle	muscle	NN
cord-262445-54ng7m92	87	13	dystrophies	dystrophy	NNS
cord-262445-54ng7m92	87	14	,	,	,
cord-262445-54ng7m92	87	15	phenotypes	phenotype	NNS
cord-262445-54ng7m92	87	16	and	and	CC
cord-262445-54ng7m92	87	17	functions	function	NNS
cord-262445-54ng7m92	87	18	of	of	IN
cord-262445-54ng7m92	87	19	macrophages	macrophage	NNS
cord-262445-54ng7m92	87	20	are	be	VBP
cord-262445-54ng7m92	87	21	altered	alter	VBN
cord-262445-54ng7m92	87	22	,	,	,
cord-262445-54ng7m92	87	23	participating	participate	VBG
cord-262445-54ng7m92	87	24	to	to	IN
cord-262445-54ng7m92	87	25	the	the	DT
cord-262445-54ng7m92	87	26	pathogeny	pathogeny	NN
cord-262445-54ng7m92	87	27	of	of	IN
cord-262445-54ng7m92	87	28	the	the	DT
cord-262445-54ng7m92	87	29	disease	disease	NN
cord-262445-54ng7m92	87	30	.	.	.
cord-262445-54ng7m92	88	1	Our	-PRON-	PRP$
cord-262445-54ng7m92	88	2	recent	recent	JJ
cord-262445-54ng7m92	88	3	investigations	investigation	NNS
cord-262445-54ng7m92	88	4	indicate	indicate	VBP
cord-262445-54ng7m92	88	5	that	that	IN
cord-262445-54ng7m92	88	6	the	the	DT
cord-262445-54ng7m92	88	7	inflammatory	inflammatory	JJ
cord-262445-54ng7m92	88	8	status	status	NN
cord-262445-54ng7m92	88	9	of	of	IN
cord-262445-54ng7m92	88	10	macrophages	macrophage	NNS
cord-262445-54ng7m92	88	11	may	may	MD
cord-262445-54ng7m92	88	12	be	be	VB
cord-262445-54ng7m92	88	13	a	a	DT
cord-262445-54ng7m92	88	14	therapeutic	therapeutic	JJ
cord-262445-54ng7m92	88	15	target	target	NN
cord-262445-54ng7m92	88	16	to	to	TO
cord-262445-54ng7m92	88	17	alleviate	alleviate	VB
cord-262445-54ng7m92	88	18	muscle	muscle	NN
cord-262445-54ng7m92	88	19	dystrophies	dystrophy	NNS
cord-262445-54ng7m92	88	20	.	.	.
cord-262445-54ng7m92	89	1	Dr.	Dr.	NNP
cord-262445-54ng7m92	89	2	Bénédicte	Bénédicte	NNP
cord-262445-54ng7m92	89	3	Chazaud	Chazaud	NNP
cord-262445-54ng7m92	89	4	is	be	VBZ
cord-262445-54ng7m92	89	5	Director	Director	NNP
cord-262445-54ng7m92	89	6	of	of	IN
cord-262445-54ng7m92	89	7	Research	Research	NNP
cord-262445-54ng7m92	89	8	class	class	NN
cord-262445-54ng7m92	89	9	1	1	CD
cord-262445-54ng7m92	89	10	(	(	-LRB-
cord-262445-54ng7m92	89	11	eq	eq	NNP
cord-262445-54ng7m92	89	12	.	.	.
cord-262445-54ng7m92	89	13	of	of	IN
cord-262445-54ng7m92	89	14	Professor	Professor	NNP
cord-262445-54ng7m92	89	15	)	)	-RRB-
cord-262445-54ng7m92	89	16	and	and	CC
cord-262445-54ng7m92	89	17	Leader	Leader	NNP
cord-262445-54ng7m92	89	18	of	of	IN
cord-262445-54ng7m92	89	19	the	the	DT
cord-262445-54ng7m92	89	20	team	team	NN
cord-262445-54ng7m92	89	21	"	"	``
cord-262445-54ng7m92	89	22	Stem	stem	JJ
cord-262445-54ng7m92	89	23	cell	cell	NN
cord-262445-54ng7m92	89	24	environment	environment	NN
cord-262445-54ng7m92	89	25	and	and	CC
cord-262445-54ng7m92	89	26	skeletal	skeletal	JJ
cord-262445-54ng7m92	89	27	muscle	muscle	NN
cord-262445-54ng7m92	89	28	homeostasis	homeostasis	NN
cord-262445-54ng7m92	89	29	"	"	''
cord-262445-54ng7m92	89	30	at	at	IN
cord-262445-54ng7m92	89	31	Institut	Institut	NNP
cord-262445-54ng7m92	89	32	NeuroMyoGène	NeuroMyoGène	NNP
cord-262445-54ng7m92	89	33	(	(	-LRB-
cord-262445-54ng7m92	89	34	INMG	INMG	NNP
cord-262445-54ng7m92	89	35	)	)	-RRB-
cord-262445-54ng7m92	89	36	INSERM	INSERM	NNP
cord-262445-54ng7m92	89	37	U1217-CNRS	U1217-CNRS	NNP
cord-262445-54ng7m92	89	38	5310	5310	CD
cord-262445-54ng7m92	89	39	,	,	,
cord-262445-54ng7m92	89	40	Université	Université	NNP
cord-262445-54ng7m92	89	41	Claude	Claude	NNP
cord-262445-54ng7m92	89	42	Bernard	Bernard	NNP
cord-262445-54ng7m92	89	43	in	in	IN
cord-262445-54ng7m92	89	44	Lyon	Lyon	NNP
cord-262445-54ng7m92	89	45	,	,	,
cord-262445-54ng7m92	89	46	France	France	NNP
cord-262445-54ng7m92	89	47	.	.	.
cord-262445-54ng7m92	90	1	The	the	DT
cord-262445-54ng7m92	90	2	research	research	NN
cord-262445-54ng7m92	90	3	of	of	IN
cord-262445-54ng7m92	90	4	her	-PRON-	PRP$
cord-262445-54ng7m92	90	5	team	team	NN
cord-262445-54ng7m92	90	6	is	be	VBZ
cord-262445-54ng7m92	90	7	dedicated	dedicated	JJ
cord-262445-54ng7m92	90	8	on	on	IN
cord-262445-54ng7m92	90	9	the	the	DT
cord-262445-54ng7m92	90	10	role	role	NN
cord-262445-54ng7m92	90	11	of	of	IN
cord-262445-54ng7m92	90	12	environmental	environmental	JJ
cord-262445-54ng7m92	90	13	cells	cell	NNS
cord-262445-54ng7m92	90	14	on	on	IN
cord-262445-54ng7m92	90	15	adult	adult	NN
cord-262445-54ng7m92	90	16	muscle	muscle	NN
cord-262445-54ng7m92	90	17	stem	stem	NN
cord-262445-54ng7m92	90	18	cell	cell	NN
cord-262445-54ng7m92	90	19	behavior	behavior	NN
cord-262445-54ng7m92	90	20	in	in	IN
cord-262445-54ng7m92	90	21	skeletal	skeletal	JJ
cord-262445-54ng7m92	90	22	muscle	muscle	NN
cord-262445-54ng7m92	90	23	regeneration	regeneration	NN
cord-262445-54ng7m92	90	24	and	and	CC
cord-262445-54ng7m92	90	25	during	during	IN
cord-262445-54ng7m92	90	26	myopathies	myopathy	NNS
cord-262445-54ng7m92	90	27	.	.	.
cord-262445-54ng7m92	91	1	The	the	DT
cord-262445-54ng7m92	91	2	Chazaud	Chazaud	NNP
cord-262445-54ng7m92	91	3	lab	lab	NN
cord-262445-54ng7m92	91	4	was	be	VBD
cord-262445-54ng7m92	91	5	pioneer	pioneer	NN
cord-262445-54ng7m92	91	6	in	in	IN
cord-262445-54ng7m92	91	7	bringing	bring	VBG
cord-262445-54ng7m92	91	8	the	the	DT
cord-262445-54ng7m92	91	9	concept	concept	NN
cord-262445-54ng7m92	91	10	of	of	IN
cord-262445-54ng7m92	91	11	a	a	DT
cord-262445-54ng7m92	91	12	stromal	stromal	JJ
cord-262445-54ng7m92	91	13	support	support	NN
cord-262445-54ng7m92	91	14	for	for	IN
cord-262445-54ng7m92	91	15	these	these	DT
cord-262445-54ng7m92	91	16	cells	cell	NNS
cord-262445-54ng7m92	91	17	to	to	TO
cord-262445-54ng7m92	91	18	promote	promote	VB
cord-262445-54ng7m92	91	19	an	an	DT
cord-262445-54ng7m92	91	20	efficient	efficient	JJ
cord-262445-54ng7m92	91	21	muscle	muscle	NN
cord-262445-54ng7m92	91	22	regeneration	regeneration	NN
cord-262445-54ng7m92	91	23	.	.	.
cord-262445-54ng7m92	92	1	Particularly	particularly	RB
cord-262445-54ng7m92	92	2	,	,	,
cord-262445-54ng7m92	92	3	they	-PRON-	PRP
cord-262445-54ng7m92	92	4	have	have	VBP
cord-262445-54ng7m92	92	5	been	be	VBN
cord-262445-54ng7m92	92	6	extensively	extensively	RB
cord-262445-54ng7m92	92	7	studying	study	VBG
cord-262445-54ng7m92	92	8	macrophage	macrophage	NN
cord-262445-54ng7m92	92	9	biology	biology	NN
cord-262445-54ng7m92	92	10	in	in	IN
cord-262445-54ng7m92	92	11	this	this	DT
cord-262445-54ng7m92	92	12	process	process	NN
cord-262445-54ng7m92	92	13	.	.	.
cord-262445-54ng7m92	93	1	They	-PRON-	PRP
cord-262445-54ng7m92	93	2	described	describe	VBD
cord-262445-54ng7m92	93	3	that	that	IN
cord-262445-54ng7m92	93	4	beyond	beyond	IN
cord-262445-54ng7m92	93	5	their	-PRON-	PRP$
cord-262445-54ng7m92	93	6	role	role	NN
cord-262445-54ng7m92	93	7	in	in	IN
cord-262445-54ng7m92	93	8	innate	innate	JJ
cord-262445-54ng7m92	93	9	immunity	immunity	NN
cord-262445-54ng7m92	93	10	through	through	IN
cord-262445-54ng7m92	93	11	scavenging	scavenging	NN
cord-262445-54ng7m92	93	12	debris	debris	NN
cord-262445-54ng7m92	93	13	,	,	,
cord-262445-54ng7m92	93	14	macrophages	macrophage	NNS
cord-262445-54ng7m92	93	15	directly	directly	RB
cord-262445-54ng7m92	93	16	act	act	VB
cord-262445-54ng7m92	93	17	on	on	IN
cord-262445-54ng7m92	93	18	muscle	muscle	NN
cord-262445-54ng7m92	93	19	stem	stem	NN
cord-262445-54ng7m92	93	20	cells	cell	NNS
cord-262445-54ng7m92	93	21	to	to	TO
cord-262445-54ng7m92	93	22	regulate	regulate	VB
cord-262445-54ng7m92	93	23	adult	adult	NN
cord-262445-54ng7m92	93	24	myogenesis	myogenesis	NN
cord-262445-54ng7m92	93	25	.	.	.
cord-262445-54ng7m92	94	1	Similarly	similarly	RB
cord-262445-54ng7m92	94	2	,	,	,
cord-262445-54ng7m92	94	3	while	while	IN
cord-262445-54ng7m92	94	4	vessels	vessel	NNS
cord-262445-54ng7m92	94	5	are	be	VBP
cord-262445-54ng7m92	94	6	usually	usually	RB
cord-262445-54ng7m92	94	7	considered	consider	VBN
cord-262445-54ng7m92	94	8	only	only	RB
cord-262445-54ng7m92	94	9	as	as	IN
cord-262445-54ng7m92	94	10	oxygen	oxygen	NN
cord-262445-54ng7m92	94	11	and	and	CC
cord-262445-54ng7m92	94	12	nutriment	nutriment	NN
cord-262445-54ng7m92	94	13	providers	provider	NNS
cord-262445-54ng7m92	94	14	,	,	,
cord-262445-54ng7m92	94	15	the	the	DT
cord-262445-54ng7m92	94	16	work	work	NN
cord-262445-54ng7m92	94	17	from	from	IN
cord-262445-54ng7m92	94	18	Dr.	Dr.	NNP
cord-262445-54ng7m92	94	19	Chazaud	Chazaud	NNP
cord-262445-54ng7m92	94	20	identified	identify	VBD
cord-262445-54ng7m92	94	21	new	new	JJ
cord-262445-54ng7m92	94	22	interactions	interaction	NNS
cord-262445-54ng7m92	94	23	between	between	IN
cord-262445-54ng7m92	94	24	endothelial	endothelial	JJ
cord-262445-54ng7m92	94	25	or	or	CC
cord-262445-54ng7m92	94	26	peri	peri	JJ
cord-262445-54ng7m92	94	27	-	-	HYPH
cord-262445-54ng7m92	94	28	endothelial	endothelial	JJ
cord-262445-54ng7m92	94	29	cells	cell	NNS
cord-262445-54ng7m92	94	30	with	with	IN
cord-262445-54ng7m92	94	31	muscle	muscle	NN
cord-262445-54ng7m92	94	32	stem	stem	NN
cord-262445-54ng7m92	94	33	cells	cell	NNS
cord-262445-54ng7m92	94	34	that	that	WDT
cord-262445-54ng7m92	94	35	regulate	regulate	VBP
cord-262445-54ng7m92	94	36	their	-PRON-	PRP$
cord-262445-54ng7m92	94	37	fate	fate	NN
cord-262445-54ng7m92	94	38	.	.	.
cord-262445-54ng7m92	95	1	The	the	DT
cord-262445-54ng7m92	95	2	goal	goal	NN
cord-262445-54ng7m92	95	3	of	of	IN
cord-262445-54ng7m92	95	4	these	these	DT
cord-262445-54ng7m92	95	5	studies	study	NNS
cord-262445-54ng7m92	95	6	is	be	VBZ
cord-262445-54ng7m92	95	7	to	to	TO
cord-262445-54ng7m92	95	8	decipher	decipher	VB
cord-262445-54ng7m92	95	9	the	the	DT
cord-262445-54ng7m92	95	10	cell	cell	NN
cord-262445-54ng7m92	95	11	interactions	interaction	NNS
cord-262445-54ng7m92	95	12	that	that	WDT
cord-262445-54ng7m92	95	13	allow	allow	VBP
cord-262445-54ng7m92	95	14	a	a	DT
cord-262445-54ng7m92	95	15	proper	proper	JJ
cord-262445-54ng7m92	95	16	myogenesis	myogenesis	NN
cord-262445-54ng7m92	95	17	after	after	IN
cord-262445-54ng7m92	95	18	muscle	muscle	NN
cord-262445-54ng7m92	95	19	injury	injury	NN
cord-262445-54ng7m92	95	20	and	and	CC
cord-262445-54ng7m92	95	21	to	to	TO
cord-262445-54ng7m92	95	22	identify	identify	VB
cord-262445-54ng7m92	95	23	the	the	DT
cord-262445-54ng7m92	95	24	molecular	molecular	JJ
cord-262445-54ng7m92	95	25	mechanisms	mechanism	NNS
cord-262445-54ng7m92	95	26	underlying	underlie	VBG
cord-262445-54ng7m92	95	27	these	these	DT
cord-262445-54ng7m92	95	28	interactions	interaction	NNS
cord-262445-54ng7m92	95	29	.	.	.
cord-262445-54ng7m92	96	1	These	these	DT
cord-262445-54ng7m92	96	2	investigations	investigation	NNS
cord-262445-54ng7m92	96	3	are	be	VBP
cord-262445-54ng7m92	96	4	pursued	pursue	VBN
cord-262445-54ng7m92	96	5	in	in	IN
cord-262445-54ng7m92	96	6	both	both	DT
cord-262445-54ng7m92	96	7	normal	normal	JJ
cord-262445-54ng7m92	96	8	muscle	muscle	NN
cord-262445-54ng7m92	96	9	regeneration	regeneration	NN
cord-262445-54ng7m92	96	10	as	as	RB
cord-262445-54ng7m92	96	11	well	well	RB
cord-262445-54ng7m92	96	12	as	as	IN
cord-262445-54ng7m92	96	13	in	in	IN
cord-262445-54ng7m92	96	14	the	the	DT
cord-262445-54ng7m92	96	15	context	context	NN
cord-262445-54ng7m92	96	16	of	of	IN
cord-262445-54ng7m92	96	17	degenerating	degenerate	VBG
cord-262445-54ng7m92	96	18	myopathies	myopathy	NNS
cord-262445-54ng7m92	96	19	.	.	.
cord-262445-54ng7m92	97	1	In	in	IN
cord-262445-54ng7m92	97	2	vitro	vitro	FW
cord-262445-54ng7m92	97	3	modeling	modeling	NN
cord-262445-54ng7m92	97	4	of	of	IN
cord-262445-54ng7m92	97	5	human	human	JJ
cord-262445-54ng7m92	97	6	muscle	muscle	NN
cord-262445-54ng7m92	97	7	development	development	NN
cord-262445-54ng7m92	97	8	and	and	CC
cord-262445-54ng7m92	97	9	disease	disease	NN
cord-262445-54ng7m92	97	10	Progress	Progress	NNP
cord-262445-54ng7m92	97	11	toward	toward	IN
cord-262445-54ng7m92	97	12	finding	find	VBG
cord-262445-54ng7m92	97	13	a	a	DT
cord-262445-54ng7m92	97	14	cure	cure	NN
cord-262445-54ng7m92	97	15	for	for	IN
cord-262445-54ng7m92	97	16	muscle	muscle	NN
cord-262445-54ng7m92	97	17	diseases	disease	NNS
cord-262445-54ng7m92	97	18	has	have	VBZ
cord-262445-54ng7m92	97	19	been	be	VBN
cord-262445-54ng7m92	97	20	slow	slow	JJ
cord-262445-54ng7m92	97	21	because	because	IN
cord-262445-54ng7m92	97	22	of	of	IN
cord-262445-54ng7m92	97	23	the	the	DT
cord-262445-54ng7m92	97	24	absence	absence	NN
cord-262445-54ng7m92	97	25	of	of	IN
cord-262445-54ng7m92	97	26	relevant	relevant	JJ
cord-262445-54ng7m92	97	27	cellular	cellular	JJ
cord-262445-54ng7m92	97	28	models	model	NNS
cord-262445-54ng7m92	97	29	and	and	CC
cord-262445-54ng7m92	97	30	the	the	DT
cord-262445-54ng7m92	97	31	lack	lack	NN
cord-262445-54ng7m92	97	32	of	of	IN
cord-262445-54ng7m92	97	33	a	a	DT
cord-262445-54ng7m92	97	34	reliable	reliable	JJ
cord-262445-54ng7m92	97	35	source	source	NN
cord-262445-54ng7m92	97	36	of	of	IN
cord-262445-54ng7m92	97	37	muscle	muscle	NN
cord-262445-54ng7m92	97	38	progenitors	progenitor	NNS
cord-262445-54ng7m92	97	39	for	for	IN
cord-262445-54ng7m92	97	40	biomedical	biomedical	JJ
cord-262445-54ng7m92	97	41	investigation	investigation	NN
cord-262445-54ng7m92	97	42	.	.	.
cord-262445-54ng7m92	98	1	We	-PRON-	PRP
cord-262445-54ng7m92	98	2	have	have	VBP
cord-262445-54ng7m92	98	3	developed	develop	VBN
cord-262445-54ng7m92	98	4	an	an	DT
cord-262445-54ng7m92	98	5	optimized	optimize	VBN
cord-262445-54ng7m92	98	6	serum	serum	NN
cord-262445-54ng7m92	98	7	-	-	HYPH
cord-262445-54ng7m92	98	8	free	free	JJ
cord-262445-54ng7m92	98	9	differentiation	differentiation	NN
cord-262445-54ng7m92	98	10	protocol	protocol	NN
cord-262445-54ng7m92	98	11	to	to	TO
cord-262445-54ng7m92	98	12	efficiently	efficiently	RB
cord-262445-54ng7m92	98	13	produce	produce	VB
cord-262445-54ng7m92	98	14	striated	striated	JJ
cord-262445-54ng7m92	98	15	,	,	,
cord-262445-54ng7m92	98	16	millimeter	millimeter	NN
cord-262445-54ng7m92	98	17	-	-	HYPH
cord-262445-54ng7m92	98	18	long	long	JJ
cord-262445-54ng7m92	98	19	muscle	muscle	NN
cord-262445-54ng7m92	98	20	fibers	fiber	NNS
cord-262445-54ng7m92	98	21	together	together	RB
cord-262445-54ng7m92	98	22	with	with	IN
cord-262445-54ng7m92	98	23	satellite	satellite	NN
cord-262445-54ng7m92	98	24	-	-	HYPH
cord-262445-54ng7m92	98	25	like	like	JJ
cord-262445-54ng7m92	98	26	cells	cell	NNS
cord-262445-54ng7m92	98	27	from	from	IN
cord-262445-54ng7m92	98	28	human	human	JJ
cord-262445-54ng7m92	98	29	pluripotent	pluripotent	JJ
cord-262445-54ng7m92	98	30	stem	stem	NN
cord-262445-54ng7m92	98	31	cells	cell	NNS
cord-262445-54ng7m92	98	32	(	(	-LRB-
cord-262445-54ng7m92	98	33	ES	ES	NNP
cord-262445-54ng7m92	98	34	/	/	SYM
cord-262445-54ng7m92	98	35	iPS	iPS	NNP
cord-262445-54ng7m92	98	36	)	)	-RRB-
cord-262445-54ng7m92	98	37	in	in	IN
cord-262445-54ng7m92	98	38	vitro	vitro	FW
cord-262445-54ng7m92	98	39	.	.	.
cord-262445-54ng7m92	99	1	By	by	IN
cord-262445-54ng7m92	99	2	mimicking	mimic	VBG
cord-262445-54ng7m92	99	3	key	key	JJ
cord-262445-54ng7m92	99	4	signaling	signal	VBG
cord-262445-54ng7m92	99	5	events	event	NNS
cord-262445-54ng7m92	99	6	leading	lead	VBG
cord-262445-54ng7m92	99	7	to	to	IN
cord-262445-54ng7m92	99	8	muscle	muscle	NN
cord-262445-54ng7m92	99	9	formation	formation	NN
cord-262445-54ng7m92	99	10	in	in	IN
cord-262445-54ng7m92	99	11	the	the	DT
cord-262445-54ng7m92	99	12	embryo	embryo	NN
cord-262445-54ng7m92	99	13	,	,	,
cord-262445-54ng7m92	99	14	this	this	DT
cord-262445-54ng7m92	99	15	directed	direct	VBN
cord-262445-54ng7m92	99	16	differentiation	differentiation	NN
cord-262445-54ng7m92	99	17	protocol	protocol	NN
cord-262445-54ng7m92	99	18	recapitulates	recapitulate	VBZ
cord-262445-54ng7m92	99	19	the	the	DT
cord-262445-54ng7m92	99	20	developmental	developmental	JJ
cord-262445-54ng7m92	99	21	sequence	sequence	NN
cord-262445-54ng7m92	99	22	of	of	IN
cord-262445-54ng7m92	99	23	myogenesis	myogenesis	NN
cord-262445-54ng7m92	99	24	and	and	CC
cord-262445-54ng7m92	99	25	avoids	avoid	VBZ
cord-262445-54ng7m92	99	26	the	the	DT
cord-262445-54ng7m92	99	27	requirement	requirement	NN
cord-262445-54ng7m92	99	28	for	for	IN
cord-262445-54ng7m92	99	29	genetic	genetic	JJ
cord-262445-54ng7m92	99	30	modifications	modification	NNS
cord-262445-54ng7m92	99	31	or	or	CC
cord-262445-54ng7m92	99	32	cell	cell	NN
cord-262445-54ng7m92	99	33	sorting	sorting	NN
cord-262445-54ng7m92	99	34	.	.	.
cord-262445-54ng7m92	100	1	We	-PRON-	PRP
cord-262445-54ng7m92	100	2	engineered	engineer	VBD
cord-262445-54ng7m92	100	3	a	a	DT
cord-262445-54ng7m92	100	4	series	series	NN
cord-262445-54ng7m92	100	5	of	of	IN
cord-262445-54ng7m92	100	6	human	human	JJ
cord-262445-54ng7m92	100	7	iPS	iPS	NNP
cord-262445-54ng7m92	100	8	reporter	reporter	NN
cord-262445-54ng7m92	100	9	lines	line	NNS
cord-262445-54ng7m92	100	10	including	include	VBG
cord-262445-54ng7m92	100	11	PAX7-YFP	PAX7-YFP	NNP
cord-262445-54ng7m92	100	12	,	,	,
cord-262445-54ng7m92	100	13	MYOG	MYOG	NNP
cord-262445-54ng7m92	100	14	-	-	HYPH
cord-262445-54ng7m92	100	15	YFP	YFP	NNP
cord-262445-54ng7m92	100	16	and	and	CC
cord-262445-54ng7m92	100	17	PAX7-YFP	PAX7-YFP	NNP
cord-262445-54ng7m92	100	18	/	/	SYM
cord-262445-54ng7m92	100	19	MYOD1-Cherry	MYOD1-Cherry	NNP
cord-262445-54ng7m92	100	20	that	that	WDT
cord-262445-54ng7m92	100	21	we	-PRON-	PRP
cord-262445-54ng7m92	100	22	used	use	VBD
cord-262445-54ng7m92	100	23	to	to	TO
cord-262445-54ng7m92	100	24	characterize	characterize	VB
cord-262445-54ng7m92	100	25	the	the	DT
cord-262445-54ng7m92	100	26	differentiation	differentiation	NN
cord-262445-54ng7m92	100	27	of	of	IN
cord-262445-54ng7m92	100	28	the	the	DT
cord-262445-54ng7m92	100	29	myogenic	myogenic	NNP
cord-262445-54ng7m92	100	30	lineage	lineage	NN
cord-262445-54ng7m92	100	31	in	in	IN
cord-262445-54ng7m92	100	32	human	human	JJ
cord-262445-54ng7m92	100	33	myogenic	myogenic	JJ
cord-262445-54ng7m92	100	34	cultures	culture	NNS
cord-262445-54ng7m92	100	35	.	.	.
cord-262445-54ng7m92	101	1	We	-PRON-	PRP
cord-262445-54ng7m92	101	2	are	be	VBP
cord-262445-54ng7m92	101	3	particularly	particularly	RB
cord-262445-54ng7m92	101	4	interested	interested	JJ
cord-262445-54ng7m92	101	5	in	in	IN
cord-262445-54ng7m92	101	6	the	the	DT
cord-262445-54ng7m92	101	7	ontogeny	ontogeny	NN
cord-262445-54ng7m92	101	8	of	of	IN
cord-262445-54ng7m92	101	9	the	the	DT
cord-262445-54ng7m92	101	10	human	human	JJ
cord-262445-54ng7m92	101	11	PAX7-expressing	pax7-expressing	NN
cord-262445-54ng7m92	101	12	lineage	lineage	NN
cord-262445-54ng7m92	101	13	that	that	WDT
cord-262445-54ng7m92	101	14	leads	lead	VBZ
cord-262445-54ng7m92	101	15	to	to	IN
cord-262445-54ng7m92	101	16	the	the	DT
cord-262445-54ng7m92	101	17	adult	adult	NN
cord-262445-54ng7m92	101	18	satellite	satellite	NN
cord-262445-54ng7m92	101	19	cells	cell	NNS
cord-262445-54ng7m92	101	20	.	.	.
cord-262445-54ng7m92	102	1	We	-PRON-	PRP
cord-262445-54ng7m92	102	2	show	show	VBP
cord-262445-54ng7m92	102	3	that	that	IN
cord-262445-54ng7m92	102	4	human	human	JJ
cord-262445-54ng7m92	102	5	PAX7-YFP	PAX7-YFP	NNP
cord-262445-54ng7m92	102	6	cells	cell	NNS
cord-262445-54ng7m92	102	7	produced	produce	VBN
cord-262445-54ng7m92	102	8	in	in	IN
cord-262445-54ng7m92	102	9	vitro	vitro	FW
cord-262445-54ng7m92	102	10	exhibit	exhibit	NN
cord-262445-54ng7m92	102	11	characteristics	characteristic	NNS
cord-262445-54ng7m92	102	12	of	of	IN
cord-262445-54ng7m92	102	13	fetal	fetal	JJ
cord-262445-54ng7m92	102	14	satellite	satellite	NN
cord-262445-54ng7m92	102	15	cells	cell	NNS
cord-262445-54ng7m92	102	16	.	.	.
cord-262445-54ng7m92	103	1	We	-PRON-	PRP
cord-262445-54ng7m92	103	2	performed	perform	VBD
cord-262445-54ng7m92	103	3	single	single	JJ
cord-262445-54ng7m92	103	4	cell	cell	NN
cord-262445-54ng7m92	103	5	RNA	rna	NN
cord-262445-54ng7m92	103	6	sequencing	sequencing	NN
cord-262445-54ng7m92	103	7	of	of	IN
cord-262445-54ng7m92	103	8	the	the	DT
cord-262445-54ng7m92	103	9	PAX7-YFP	PAX7-YFP	NNP
cord-262445-54ng7m92	103	10	cells	cell	NNS
cord-262445-54ng7m92	103	11	generated	generate	VBN
cord-262445-54ng7m92	103	12	in	in	IN
cord-262445-54ng7m92	103	13	vitro	vitro	FW
cord-262445-54ng7m92	103	14	and	and	CC
cord-262445-54ng7m92	103	15	identified	identify	VBD
cord-262445-54ng7m92	103	16	the	the	DT
cord-262445-54ng7m92	103	17	major	major	JJ
cord-262445-54ng7m92	103	18	steps	step	NNS
cord-262445-54ng7m92	103	19	of	of	IN
cord-262445-54ng7m92	103	20	the	the	DT
cord-262445-54ng7m92	103	21	differentiation	differentiation	NN
cord-262445-54ng7m92	103	22	of	of	IN
cord-262445-54ng7m92	103	23	this	this	DT
cord-262445-54ng7m92	103	24	lineage	lineage	NN
cord-262445-54ng7m92	103	25	.	.	.
cord-262445-54ng7m92	104	1	This	this	DT
cord-262445-54ng7m92	104	2	work	work	NN
cord-262445-54ng7m92	104	3	provides	provide	VBZ
cord-262445-54ng7m92	104	4	a	a	DT
cord-262445-54ng7m92	104	5	framework	framework	NN
cord-262445-54ng7m92	104	6	to	to	TO
cord-262445-54ng7m92	104	7	study	study	VB
cord-262445-54ng7m92	104	8	early	early	JJ
cord-262445-54ng7m92	104	9	stages	stage	NNS
cord-262445-54ng7m92	104	10	of	of	IN
cord-262445-54ng7m92	104	11	human	human	JJ
cord-262445-54ng7m92	104	12	myogenesis	myogenesis	NN
cord-262445-54ng7m92	104	13	which	which	WDT
cord-262445-54ng7m92	104	14	are	be	VBP
cord-262445-54ng7m92	104	15	poorly	poorly	RB
cord-262445-54ng7m92	104	16	accessible	accessible	JJ
cord-262445-54ng7m92	104	17	in	in	IN
cord-262445-54ng7m92	104	18	the	the	DT
cord-262445-54ng7m92	104	19	embryo	embryo	NN
cord-262445-54ng7m92	104	20	.	.	.
cord-262445-54ng7m92	105	1	Olivier	Olivier	NNP
cord-262445-54ng7m92	105	2	Pourquie	Pourquie	NNP
cord-262445-54ng7m92	105	3	is	be	VBZ
cord-262445-54ng7m92	105	4	Professor	Professor	NNP
cord-262445-54ng7m92	105	5	in	in	IN
cord-262445-54ng7m92	105	6	the	the	DT
cord-262445-54ng7m92	105	7	Department	Department	NNP
cord-262445-54ng7m92	105	8	of	of	IN
cord-262445-54ng7m92	105	9	Genetics	Genetics	NNP
cord-262445-54ng7m92	105	10	at	at	IN
cord-262445-54ng7m92	105	11	Harvard	Harvard	NNP
cord-262445-54ng7m92	105	12	Medical	Medical	NNP
cord-262445-54ng7m92	105	13	School	School	NNP
cord-262445-54ng7m92	105	14	and	and	CC
cord-262445-54ng7m92	105	15	Professor	Professor	NNP
cord-262445-54ng7m92	105	16	of	of	IN
cord-262445-54ng7m92	105	17	Pathology	Pathology	NNP
cord-262445-54ng7m92	105	18	at	at	IN
cord-262445-54ng7m92	105	19	the	the	DT
cord-262445-54ng7m92	105	20	Brigham	Brigham	NNP
cord-262445-54ng7m92	105	21	and	and	CC
cord-262445-54ng7m92	105	22	Women	Women	NNP
cord-262445-54ng7m92	105	23	's	's	POS
cord-262445-54ng7m92	105	24	Hospital	Hospital	NNP
cord-262445-54ng7m92	105	25	.	.	.
cord-262445-54ng7m92	106	1	He	-PRON-	PRP
cord-262445-54ng7m92	106	2	is	be	VBZ
cord-262445-54ng7m92	106	3	an	an	DT
cord-262445-54ng7m92	106	4	Associate	Associate	NNP
cord-262445-54ng7m92	106	5	Member	Member	NNP
cord-262445-54ng7m92	106	6	of	of	IN
cord-262445-54ng7m92	106	7	the	the	DT
cord-262445-54ng7m92	106	8	Broad	Broad	NNP
cord-262445-54ng7m92	106	9	Institute	Institute	NNP
cord-262445-54ng7m92	106	10	and	and	CC
cord-262445-54ng7m92	106	11	a	a	DT
cord-262445-54ng7m92	106	12	Principal	Principal	NNP
cord-262445-54ng7m92	106	13	Faculty	Faculty	NNP
cord-262445-54ng7m92	106	14	member	member	NN
cord-262445-54ng7m92	106	15	at	at	IN
cord-262445-54ng7m92	106	16	the	the	DT
cord-262445-54ng7m92	106	17	Harvard	Harvard	NNP
cord-262445-54ng7m92	106	18	Stem	Stem	NNP
cord-262445-54ng7m92	106	19	Cell	Cell	NNP
cord-262445-54ng7m92	106	20	Institute	Institute	NNP
cord-262445-54ng7m92	106	21	.	.	.
cord-262445-54ng7m92	107	1	He	-PRON-	PRP
cord-262445-54ng7m92	107	2	was	be	VBD
cord-262445-54ng7m92	107	3	the	the	DT
cord-262445-54ng7m92	107	4	director	director	NN
cord-262445-54ng7m92	107	5	of	of	IN
cord-262445-54ng7m92	107	6	the	the	DT
cord-262445-54ng7m92	107	7	Institute	Institute	NNP
cord-262445-54ng7m92	107	8	for	for	IN
cord-262445-54ng7m92	107	9	Genetics	Genetics	NNP
cord-262445-54ng7m92	107	10	and	and	CC
cord-262445-54ng7m92	107	11	Molecular	Molecular	NNP
cord-262445-54ng7m92	107	12	and	and	CC
cord-262445-54ng7m92	107	13	Cellular	Cellular	NNP
cord-262445-54ng7m92	107	14	Biology	Biology	NNP
cord-262445-54ng7m92	107	15	(	(	-LRB-
cord-262445-54ng7m92	107	16	IGBMC	IGBMC	NNP
cord-262445-54ng7m92	107	17	)	)	-RRB-
cord-262445-54ng7m92	107	18	in	in	IN
cord-262445-54ng7m92	107	19	France	France	NNP
cord-262445-54ng7m92	107	20	and	and	CC
cord-262445-54ng7m92	107	21	before	before	IN
cord-262445-54ng7m92	107	22	that	that	DT
cord-262445-54ng7m92	107	23	a	a	DT
cord-262445-54ng7m92	107	24	Howard	Howard	NNP
cord-262445-54ng7m92	107	25	Hughes	Hughes	NNP
cord-262445-54ng7m92	107	26	Medical	Medical	NNP
cord-262445-54ng7m92	107	27	Institute	Institute	NNP
cord-262445-54ng7m92	107	28	Investigator	Investigator	NNP
cord-262445-54ng7m92	107	29	at	at	IN
cord-262445-54ng7m92	107	30	the	the	DT
cord-262445-54ng7m92	107	31	Stowers	Stowers	NNP
cord-262445-54ng7m92	107	32	Institute	Institute	NNP
cord-262445-54ng7m92	107	33	for	for	IN
cord-262445-54ng7m92	107	34	Medical	Medical	NNP
cord-262445-54ng7m92	107	35	Institute	Institute	NNP
cord-262445-54ng7m92	107	36	in	in	IN
cord-262445-54ng7m92	107	37	Kansas	Kansas	NNP
cord-262445-54ng7m92	107	38	City	City	NNP
cord-262445-54ng7m92	107	39	.	.	.
cord-262445-54ng7m92	108	1	The	the	DT
cord-262445-54ng7m92	108	2	Pourquie	Pourquie	NNP
cord-262445-54ng7m92	108	3	laboratory	laboratory	NN
cord-262445-54ng7m92	108	4	is	be	VBZ
cord-262445-54ng7m92	108	5	a	a	DT
cord-262445-54ng7m92	108	6	world	world	NN
cord-262445-54ng7m92	108	7	leader	leader	NN
cord-262445-54ng7m92	108	8	in	in	IN
cord-262445-54ng7m92	108	9	vertebrate	vertebrate	JJ
cord-262445-54ng7m92	108	10	musculo	musculo	JJ
cord-262445-54ng7m92	108	11	-	-	JJ
cord-262445-54ng7m92	108	12	skeletal	skeletal	JJ
cord-262445-54ng7m92	108	13	axis	axis	NN
cord-262445-54ng7m92	108	14	development	development	NN
cord-262445-54ng7m92	108	15	.	.	.
cord-262445-54ng7m92	109	1	Using	use	VBG
cord-262445-54ng7m92	109	2	chicken	chicken	NN
cord-262445-54ng7m92	109	3	and	and	CC
cord-262445-54ng7m92	109	4	mouse	mouse	NN
cord-262445-54ng7m92	109	5	embryos	embryo	NNS
cord-262445-54ng7m92	109	6	as	as	IN
cord-262445-54ng7m92	109	7	model	model	NN
cord-262445-54ng7m92	109	8	systems	system	NNS
cord-262445-54ng7m92	109	9	,	,	,
cord-262445-54ng7m92	109	10	they	-PRON-	PRP
cord-262445-54ng7m92	109	11	combine	combine	VBP
cord-262445-54ng7m92	109	12	developmental	developmental	JJ
cord-262445-54ng7m92	109	13	biology	biology	NN
cord-262445-54ng7m92	109	14	and	and	CC
cord-262445-54ng7m92	109	15	genomic	genomic	JJ
cord-262445-54ng7m92	109	16	approaches	approach	NNS
cord-262445-54ng7m92	109	17	to	to	TO
cord-262445-54ng7m92	109	18	study	study	VB
cord-262445-54ng7m92	109	19	patterning	patterning	NN
cord-262445-54ng7m92	109	20	and	and	CC
cord-262445-54ng7m92	109	21	differentiation	differentiation	NN
cord-262445-54ng7m92	109	22	of	of	IN
cord-262445-54ng7m92	109	23	the	the	DT
cord-262445-54ng7m92	109	24	precursors	precursor	NNS
cord-262445-54ng7m92	109	25	of	of	IN
cord-262445-54ng7m92	109	26	muscles	muscle	NNS
cord-262445-54ng7m92	109	27	and	and	CC
cord-262445-54ng7m92	109	28	vertebrae	vertebrae	NN
cord-262445-54ng7m92	109	29	.	.	.
cord-262445-54ng7m92	110	1	They	-PRON-	PRP
cord-262445-54ng7m92	110	2	also	also	RB
cord-262445-54ng7m92	110	3	develop	develop	VBP
cord-262445-54ng7m92	110	4	quantitative	quantitative	JJ
cord-262445-54ng7m92	110	5	approaches	approach	NNS
cord-262445-54ng7m92	110	6	at	at	IN
cord-262445-54ng7m92	110	7	the	the	DT
cord-262445-54ng7m92	110	8	interface	interface	NN
cord-262445-54ng7m92	110	9	with	with	IN
cord-262445-54ng7m92	110	10	physics	physic	NNS
cord-262445-54ng7m92	110	11	to	to	TO
cord-262445-54ng7m92	110	12	study	study	VB
cord-262445-54ng7m92	110	13	morphogenesis	morphogenesis	NN
cord-262445-54ng7m92	110	14	of	of	IN
cord-262445-54ng7m92	110	15	the	the	DT
cord-262445-54ng7m92	110	16	vertebral	vertebral	JJ
cord-262445-54ng7m92	110	17	column	column	NN
cord-262445-54ng7m92	110	18	.	.	.
cord-262445-54ng7m92	111	1	While	while	IN
cord-262445-54ng7m92	111	2	most	most	JJS
cord-262445-54ng7m92	111	3	of	of	IN
cord-262445-54ng7m92	111	4	this	this	DT
cord-262445-54ng7m92	111	5	work	work	NN
cord-262445-54ng7m92	111	6	is	be	VBZ
cord-262445-54ng7m92	111	7	being	be	VBG
cord-262445-54ng7m92	111	8	carried	carry	VBN
cord-262445-54ng7m92	111	9	out	out	RP
cord-262445-54ng7m92	111	10	in	in	IN
cord-262445-54ng7m92	111	11	vivo	vivo	NN
cord-262445-54ng7m92	111	12	,	,	,
cord-262445-54ng7m92	111	13	they	-PRON-	PRP
cord-262445-54ng7m92	111	14	also	also	RB
cord-262445-54ng7m92	111	15	develop	develop	VBP
cord-262445-54ng7m92	111	16	protocols	protocol	NNS
cord-262445-54ng7m92	111	17	to	to	TO
cord-262445-54ng7m92	111	18	recapitulate	recapitulate	VB
cord-262445-54ng7m92	111	19	these	these	DT
cord-262445-54ng7m92	111	20	early	early	JJ
cord-262445-54ng7m92	111	21	developmental	developmental	JJ
cord-262445-54ng7m92	111	22	processes	process	NNS
cord-262445-54ng7m92	111	23	in	in	IN
cord-262445-54ng7m92	111	24	vitro	vitro	FW
cord-262445-54ng7m92	111	25	using	use	VBG
cord-262445-54ng7m92	111	26	mouse	mouse	NN
cord-262445-54ng7m92	111	27	and	and	CC
cord-262445-54ng7m92	111	28	human	human	JJ
cord-262445-54ng7m92	111	29	embryonic	embryonic	NNS
cord-262445-54ng7m92	111	30	or	or	CC
cord-262445-54ng7m92	111	31	reprogrammed	reprogramme	VBN
cord-262445-54ng7m92	111	32	stem	stem	NN
cord-262445-54ng7m92	111	33	cells	cell	NNS
cord-262445-54ng7m92	111	34	.	.	.
cord-262445-54ng7m92	112	1	They	-PRON-	PRP
cord-262445-54ng7m92	112	2	are	be	VBP
cord-262445-54ng7m92	112	3	also	also	RB
cord-262445-54ng7m92	112	4	turning	turn	VBG
cord-262445-54ng7m92	112	5	to	to	IN
cord-262445-54ng7m92	112	6	translational	translational	JJ
cord-262445-54ng7m92	112	7	approaches	approach	NNS
cord-262445-54ng7m92	112	8	,	,	,
cord-262445-54ng7m92	112	9	using	use	VBG
cord-262445-54ng7m92	112	10	their	-PRON-	PRP$
cord-262445-54ng7m92	112	11	understanding	understanding	NN
cord-262445-54ng7m92	112	12	of	of	IN
cord-262445-54ng7m92	112	13	the	the	DT
cord-262445-54ng7m92	112	14	early	early	JJ
cord-262445-54ng7m92	112	15	development	development	NN
cord-262445-54ng7m92	112	16	to	to	TO
cord-262445-54ng7m92	112	17	produce	produce	VB
cord-262445-54ng7m92	112	18	cells	cell	NNS
cord-262445-54ng7m92	112	19	of	of	IN
cord-262445-54ng7m92	112	20	the	the	DT
cord-262445-54ng7m92	112	21	muscle	muscle	NN
cord-262445-54ng7m92	112	22	and	and	CC
cord-262445-54ng7m92	112	23	vertebral	vertebral	JJ
cord-262445-54ng7m92	112	24	lineages	lineage	NNS
cord-262445-54ng7m92	112	25	in	in	IN
cord-262445-54ng7m92	112	26	vitro	vitro	FW
cord-262445-54ng7m92	112	27	from	from	IN
cord-262445-54ng7m92	112	28	pluripotent	pluripotent	JJ
cord-262445-54ng7m92	112	29	cells	cell	NNS
cord-262445-54ng7m92	112	30	to	to	TO
cord-262445-54ng7m92	112	31	study	study	VB
cord-262445-54ng7m92	112	32	human	human	JJ
cord-262445-54ng7m92	112	33	diseases	disease	NNS
cord-262445-54ng7m92	112	34	of	of	IN
cord-262445-54ng7m92	112	35	the	the	DT
cord-262445-54ng7m92	112	36	musculo	musculo	JJ
cord-262445-54ng7m92	112	37	-	-	JJ
cord-262445-54ng7m92	112	38	skeletal	skeletal	JJ
cord-262445-54ng7m92	112	39	axis	axis	NN
cord-262445-54ng7m92	112	40	and	and	CC
cord-262445-54ng7m92	112	41	for	for	IN
cord-262445-54ng7m92	112	42	cell	cell	NN
cord-262445-54ng7m92	112	43	therapy	therapy	NN
cord-262445-54ng7m92	112	44	approaches	approach	NNS
cord-262445-54ng7m92	112	45	.	.	.
cord-262445-54ng7m92	113	1	Dr.	Dr.	NNP
cord-262445-54ng7m92	113	2	Pourquie	Pourquie	NNP
cord-262445-54ng7m92	113	3	graduated	graduate	VBD
cord-262445-54ng7m92	113	4	as	as	IN
cord-262445-54ng7m92	113	5	an	an	DT
cord-262445-54ng7m92	113	6	engineer	engineer	NN
cord-262445-54ng7m92	113	7	in	in	IN
cord-262445-54ng7m92	113	8	France	France	NNP
cord-262445-54ng7m92	113	9	and	and	CC
cord-262445-54ng7m92	113	10	trained	train	VBN
cord-262445-54ng7m92	113	11	with	with	IN
cord-262445-54ng7m92	113	12	Nicole	Nicole	NNP
cord-262445-54ng7m92	113	13	Le	Le	NNP
cord-262445-54ng7m92	113	14	Douarin	Douarin	NNP
cord-262445-54ng7m92	113	15	in	in	IN
cord-262445-54ng7m92	113	16	Paris	Paris	NNP
cord-262445-54ng7m92	113	17	.	.	.
cord-262445-54ng7m92	114	1	He	-PRON-	PRP
cord-262445-54ng7m92	114	2	authored	author	VBD
cord-262445-54ng7m92	114	3	more	more	JJR
cord-262445-54ng7m92	114	4	than	than	IN
cord-262445-54ng7m92	114	5	100	100	CD
cord-262445-54ng7m92	114	6	peer	peer	NN
cord-262445-54ng7m92	114	7	-	-	HYPH
cord-262445-54ng7m92	114	8	reviewed	review	VBN
cord-262445-54ng7m92	114	9	publications	publication	NNS
cord-262445-54ng7m92	114	10	.	.	.
cord-262445-54ng7m92	115	1	He	-PRON-	PRP
cord-262445-54ng7m92	115	2	is	be	VBZ
cord-262445-54ng7m92	115	3	an	an	DT
cord-262445-54ng7m92	115	4	elected	elect	VBN
cord-262445-54ng7m92	115	5	member	member	NN
cord-262445-54ng7m92	115	6	of	of	IN
cord-262445-54ng7m92	115	7	the	the	DT
cord-262445-54ng7m92	115	8	European	European	NNP
cord-262445-54ng7m92	115	9	Molecular	Molecular	NNP
cord-262445-54ng7m92	115	10	Biology	Biology	NNP
cord-262445-54ng7m92	115	11	Organization	Organization	NNP
cord-262445-54ng7m92	115	12	and	and	CC
cord-262445-54ng7m92	115	13	of	of	IN
cord-262445-54ng7m92	115	14	the	the	DT
cord-262445-54ng7m92	115	15	Academia	Academia	NNP
cord-262445-54ng7m92	115	16	Europea	Europea	NNP
cord-262445-54ng7m92	115	17	.	.	.
cord-262445-54ng7m92	116	1	His	-PRON-	PRP$
cord-262445-54ng7m92	116	2	work	work	NN
cord-262445-54ng7m92	116	3	on	on	IN
cord-262445-54ng7m92	116	4	the	the	DT
cord-262445-54ng7m92	116	5	segmentation	segmentation	NN
cord-262445-54ng7m92	116	6	clock	clock	NN
cord-262445-54ng7m92	116	7	that	that	WDT
cord-262445-54ng7m92	116	8	controls	control	VBZ
cord-262445-54ng7m92	116	9	the	the	DT
cord-262445-54ng7m92	116	10	periodicity	periodicity	NN
cord-262445-54ng7m92	116	11	of	of	IN
cord-262445-54ng7m92	116	12	vertebrae	vertebrae	NN
cord-262445-54ng7m92	116	13	was	be	VBD
cord-262445-54ng7m92	116	14	recognized	recognize	VBN
cord-262445-54ng7m92	116	15	as	as	IN
cord-262445-54ng7m92	116	16	one	one	CD
cord-262445-54ng7m92	116	17	of	of	IN
cord-262445-54ng7m92	116	18	the	the	DT
cord-262445-54ng7m92	116	19	milestones	milestone	NNS
cord-262445-54ng7m92	116	20	in	in	IN
cord-262445-54ng7m92	116	21	developmental	developmental	JJ
cord-262445-54ng7m92	116	22	biology	biology	NN
cord-262445-54ng7m92	116	23	of	of	IN
cord-262445-54ng7m92	116	24	the	the	DT
cord-262445-54ng7m92	116	25	20th	20th	JJ
cord-262445-54ng7m92	116	26	century	century	NN
cord-262445-54ng7m92	116	27	by	by	IN
cord-262445-54ng7m92	116	28	Nature	Nature	NNP
cord-262445-54ng7m92	116	29	Magazine	Magazine	NNP
cord-262445-54ng7m92	116	30	.	.	.
cord-262445-54ng7m92	117	1	Amyotrophic	Amyotrophic	NNP
cord-262445-54ng7m92	117	2	Lateral	Lateral	NNP
cord-262445-54ng7m92	117	3	Sclerosis	Sclerosis	NNP
cord-262445-54ng7m92	117	4	(	(	-LRB-
cord-262445-54ng7m92	117	5	ALS	ALS	NNP
cord-262445-54ng7m92	117	6	)	)	-RRB-
cord-262445-54ng7m92	117	7	is	be	VBZ
cord-262445-54ng7m92	117	8	a	a	DT
cord-262445-54ng7m92	117	9	fatal	fatal	JJ
cord-262445-54ng7m92	117	10	neurodegenerative	neurodegenerative	JJ
cord-262445-54ng7m92	117	11	disease	disease	NN
cord-262445-54ng7m92	117	12	,	,	,
cord-262445-54ng7m92	117	13	characterised	characterise	VBN
cord-262445-54ng7m92	117	14	by	by	IN
cord-262445-54ng7m92	117	15	muscle	muscle	NN
cord-262445-54ng7m92	117	16	atrophy	atrophy	NN
cord-262445-54ng7m92	117	17	,	,	,
cord-262445-54ng7m92	117	18	weakness	weakness	NN
cord-262445-54ng7m92	117	19	,	,	,
cord-262445-54ng7m92	117	20	and	and	CC
cord-262445-54ng7m92	117	21	progressive	progressive	JJ
cord-262445-54ng7m92	117	22	degeneration	degeneration	NN
cord-262445-54ng7m92	117	23	of	of	IN
cord-262445-54ng7m92	117	24	motor	motor	NN
cord-262445-54ng7m92	117	25	neurons	neuron	NNS
cord-262445-54ng7m92	117	26	,	,	,
cord-262445-54ng7m92	117	27	leading	lead	VBG
cord-262445-54ng7m92	117	28	to	to	IN
cord-262445-54ng7m92	117	29	death	death	NN
cord-262445-54ng7m92	117	30	by	by	IN
cord-262445-54ng7m92	117	31	respiratory	respiratory	JJ
cord-262445-54ng7m92	117	32	failure	failure	NN
cord-262445-54ng7m92	117	33	within	within	IN
cord-262445-54ng7m92	117	34	2/5	2/5	CD
cord-262445-54ng7m92	117	35	years	year	NNS
cord-262445-54ng7m92	117	36	from	from	IN
cord-262445-54ng7m92	117	37	the	the	DT
cord-262445-54ng7m92	117	38	onset	onset	NN
cord-262445-54ng7m92	117	39	of	of	IN
cord-262445-54ng7m92	117	40	clinical	clinical	JJ
cord-262445-54ng7m92	117	41	symptoms	symptom	NNS
cord-262445-54ng7m92	117	42	.	.	.
cord-262445-54ng7m92	118	1	Diagnosis	diagnosis	NN
cord-262445-54ng7m92	118	2	of	of	IN
cord-262445-54ng7m92	118	3	ALS	als	NN
cord-262445-54ng7m92	118	4	relies	rely	VBZ
cord-262445-54ng7m92	118	5	only	only	RB
cord-262445-54ng7m92	118	6	on	on	IN
cord-262445-54ng7m92	118	7	clinical	clinical	JJ
cord-262445-54ng7m92	118	8	,	,	,
cord-262445-54ng7m92	118	9	electrophysiological	electrophysiological	JJ
cord-262445-54ng7m92	118	10	and	and	CC
cord-262445-54ng7m92	118	11	neuropathological	neuropathological	JJ
cord-262445-54ng7m92	118	12	examination	examination	NN
cord-262445-54ng7m92	118	13	,	,	,
cord-262445-54ng7m92	118	14	and	and	CC
cord-262445-54ng7m92	118	15	is	be	VBZ
cord-262445-54ng7m92	118	16	based	base	VBN
cord-262445-54ng7m92	118	17	on	on	IN
cord-262445-54ng7m92	118	18	the	the	DT
cord-262445-54ng7m92	118	19	exclusion	exclusion	NN
cord-262445-54ng7m92	118	20	of	of	IN
cord-262445-54ng7m92	118	21	alternative	alternative	JJ
cord-262445-54ng7m92	118	22	related	relate	VBN
cord-262445-54ng7m92	118	23	pathologies	pathology	NNS
cord-262445-54ng7m92	118	24	.	.	.
cord-262445-54ng7m92	119	1	Nowadays	nowadays	RB
cord-262445-54ng7m92	119	2	specific	specific	JJ
cord-262445-54ng7m92	119	3	molecular	molecular	JJ
cord-262445-54ng7m92	119	4	markers	marker	NNS
cord-262445-54ng7m92	119	5	for	for	IN
cord-262445-54ng7m92	119	6	ALS	als	NN
cord-262445-54ng7m92	119	7	diagnosis	diagnosis	NN
cord-262445-54ng7m92	119	8	or	or	CC
cord-262445-54ng7m92	119	9	prognosis	prognosis	NN
cord-262445-54ng7m92	119	10	are	be	VBP
cord-262445-54ng7m92	119	11	not	not	RB
cord-262445-54ng7m92	119	12	available	available	JJ
cord-262445-54ng7m92	119	13	.	.	.
cord-262445-54ng7m92	120	1	MicroRNAs	microrna	NNS
cord-262445-54ng7m92	120	2	are	be	VBP
cord-262445-54ng7m92	120	3	a	a	DT
cord-262445-54ng7m92	120	4	class	class	NN
cord-262445-54ng7m92	120	5	of	of	IN
cord-262445-54ng7m92	120	6	highly	highly	RB
cord-262445-54ng7m92	120	7	stable	stable	JJ
cord-262445-54ng7m92	120	8	molecules	molecule	NNS
cord-262445-54ng7m92	120	9	,	,	,
cord-262445-54ng7m92	120	10	detectable	detectable	JJ
cord-262445-54ng7m92	120	11	in	in	IN
cord-262445-54ng7m92	120	12	serum	serum	NN
cord-262445-54ng7m92	120	13	samples	sample	NNS
cord-262445-54ng7m92	120	14	,	,	,
cord-262445-54ng7m92	120	15	recently	recently	RB
cord-262445-54ng7m92	120	16	proposed	propose	VBN
cord-262445-54ng7m92	120	17	as	as	IN
cord-262445-54ng7m92	120	18	biomarkers	biomarker	NNS
cord-262445-54ng7m92	120	19	for	for	IN
cord-262445-54ng7m92	120	20	several	several	JJ
cord-262445-54ng7m92	120	21	human	human	JJ
cord-262445-54ng7m92	120	22	diseases	disease	NNS
cord-262445-54ng7m92	120	23	,	,	,
cord-262445-54ng7m92	120	24	such	such	JJ
cord-262445-54ng7m92	120	25	as	as	IN
cord-262445-54ng7m92	120	26	cancer	cancer	NN
cord-262445-54ng7m92	120	27	and	and	CC
cord-262445-54ng7m92	120	28	muscular	muscular	JJ
cord-262445-54ng7m92	120	29	disorders	disorder	NNS
cord-262445-54ng7m92	120	30	.	.	.
cord-262445-54ng7m92	121	1	The	the	DT
cord-262445-54ng7m92	121	2	aim	aim	NN
cord-262445-54ng7m92	121	3	of	of	IN
cord-262445-54ng7m92	121	4	the	the	DT
cord-262445-54ng7m92	121	5	present	present	JJ
cord-262445-54ng7m92	121	6	study	study	NN
cord-262445-54ng7m92	121	7	was	be	VBD
cord-262445-54ng7m92	121	8	to	to	TO
cord-262445-54ng7m92	121	9	identify	identify	VB
cord-262445-54ng7m92	121	10	circulating	circulate	VBG
cord-262445-54ng7m92	121	11	microRNAs	microrna	NNS
cord-262445-54ng7m92	121	12	as	as	IN
cord-262445-54ng7m92	121	13	serum	serum	NN
cord-262445-54ng7m92	121	14	molecular	molecular	JJ
cord-262445-54ng7m92	121	15	markers	marker	NNS
cord-262445-54ng7m92	121	16	of	of	IN
cord-262445-54ng7m92	121	17	ALS	als	NN
cord-262445-54ng7m92	121	18	disease	disease	NN
cord-262445-54ng7m92	121	19	.	.	.
cord-262445-54ng7m92	122	1	Indeed	indeed	RB
cord-262445-54ng7m92	122	2	,	,	,
cord-262445-54ng7m92	122	3	we	-PRON-	PRP
cord-262445-54ng7m92	122	4	performed	perform	VBD
cord-262445-54ng7m92	122	5	an	an	DT
cord-262445-54ng7m92	122	6	NGS	NGS	NNP
cord-262445-54ng7m92	122	7	analysis	analysis	NN
cord-262445-54ng7m92	122	8	on	on	IN
cord-262445-54ng7m92	122	9	a	a	DT
cord-262445-54ng7m92	122	10	sub	sub	NN
cord-262445-54ng7m92	122	11	-	-	JJ
cord-262445-54ng7m92	122	12	cohort	cohort	NN
cord-262445-54ng7m92	122	13	of	of	IN
cord-262445-54ng7m92	122	14	patients	patient	NNS
cord-262445-54ng7m92	122	15	,	,	,
cord-262445-54ng7m92	122	16	and	and	CC
cord-262445-54ng7m92	122	17	we	-PRON-	PRP
cord-262445-54ng7m92	122	18	identified	identify	VBD
cord-262445-54ng7m92	122	19	several	several	JJ
cord-262445-54ng7m92	122	20	differentially	differentially	RB
cord-262445-54ng7m92	122	21	expressed	express	VBN
cord-262445-54ng7m92	122	22	microRNAs	microrna	NNS
cord-262445-54ng7m92	122	23	.	.	.
cord-262445-54ng7m92	123	1	Moreover	moreover	RB
cord-262445-54ng7m92	123	2	,	,	,
cord-262445-54ng7m92	123	3	we	-PRON-	PRP
cord-262445-54ng7m92	123	4	analysed	analyse	VBD
cord-262445-54ng7m92	123	5	a	a	DT
cord-262445-54ng7m92	123	6	subset	subset	NN
cord-262445-54ng7m92	123	7	of	of	IN
cord-262445-54ng7m92	123	8	microRNAs	microRNAs	NNPS
cord-262445-54ng7m92	123	9	preferentially	preferentially	RB
cord-262445-54ng7m92	123	10	expressed	express	VBN
cord-262445-54ng7m92	123	11	in	in	IN
cord-262445-54ng7m92	123	12	skeletal	skeletal	JJ
cord-262445-54ng7m92	123	13	muscle	muscle	NN
cord-262445-54ng7m92	123	14	(	(	-LRB-
cord-262445-54ng7m92	123	15	myo	myo	NNP
cord-262445-54ng7m92	123	16	-	-	HYPH
cord-262445-54ng7m92	123	17	miRNAs	miRNAs	NNP
cord-262445-54ng7m92	123	18	)	)	-RRB-
cord-262445-54ng7m92	123	19	,	,	,
cord-262445-54ng7m92	123	20	involved	involve	VBN
cord-262445-54ng7m92	123	21	in	in	IN
cord-262445-54ng7m92	123	22	myogenesis	myogenesis	NN
cord-262445-54ng7m92	123	23	,	,	,
cord-262445-54ng7m92	123	24	and	and	CC
cord-262445-54ng7m92	123	25	skeletal	skeletal	JJ
cord-262445-54ng7m92	123	26	muscle	muscle	NN
cord-262445-54ng7m92	123	27	differentiation	differentiation	NN
cord-262445-54ng7m92	123	28	and	and	CC
cord-262445-54ng7m92	123	29	regeneration	regeneration	NN
cord-262445-54ng7m92	123	30	.	.	.
cord-262445-54ng7m92	124	1	Here	here	RB
cord-262445-54ng7m92	124	2	we	-PRON-	PRP
cord-262445-54ng7m92	124	3	provide	provide	VBP
cord-262445-54ng7m92	124	4	a	a	DT
cord-262445-54ng7m92	124	5	longitudinal	longitudinal	JJ
cord-262445-54ng7m92	124	6	study	study	NN
cord-262445-54ng7m92	124	7	on	on	IN
cord-262445-54ng7m92	124	8	serum	serum	NN
cord-262445-54ng7m92	124	9	samples	sample	NNS
cord-262445-54ng7m92	124	10	of	of	IN
cord-262445-54ng7m92	124	11	27	27	CD
cord-262445-54ng7m92	124	12	spinalonset	spinalonset	NNS
cord-262445-54ng7m92	124	13	ALS	ALS	NNP
cord-262445-54ng7m92	124	14	patients	patient	NNS
cord-262445-54ng7m92	124	15	,	,	,
cord-262445-54ng7m92	124	16	analysed	analyse	VBD
cord-262445-54ng7m92	124	17	every	every	DT
cord-262445-54ng7m92	124	18	three	three	CD
cord-262445-54ng7m92	124	19	months	month	NNS
cord-262445-54ng7m92	124	20	by	by	IN
cord-262445-54ng7m92	124	21	absolute	absolute	JJ
cord-262445-54ng7m92	124	22	RT	RT	NNP
cord-262445-54ng7m92	124	23	quantification	quantification	NN
cord-262445-54ng7m92	124	24	.	.	.
cord-262445-54ng7m92	125	1	We	-PRON-	PRP
cord-262445-54ng7m92	125	2	associated	associate	VBD
cord-262445-54ng7m92	125	3	serum	serum	NN
cord-262445-54ng7m92	125	4	levels	level	NNS
cord-262445-54ng7m92	125	5	of	of	IN
cord-262445-54ng7m92	125	6	the	the	DT
cord-262445-54ng7m92	125	7	identified	identify	VBN
cord-262445-54ng7m92	125	8	microRNAs	microRNAs	NNPS
cord-262445-54ng7m92	125	9	with	with	IN
cord-262445-54ng7m92	125	10	the	the	DT
cord-262445-54ng7m92	125	11	disease	disease	NN
cord-262445-54ng7m92	125	12	stage	stage	NN
cord-262445-54ng7m92	125	13	,	,	,
cord-262445-54ng7m92	125	14	evaluated	evaluate	VBN
cord-262445-54ng7m92	125	15	by	by	IN
cord-262445-54ng7m92	125	16	ALS	ALS	NNP
cord-262445-54ng7m92	126	1	-Health	-Health	NFP
cord-262445-54ng7m92	126	2	State	State	NNP
cord-262445-54ng7m92	126	3	Scale	Scale	NNP
cord-262445-54ng7m92	126	4	(	(	-LRB-
cord-262445-54ng7m92	126	5	ALS	als	NN
cord-262445-54ng7m92	126	6	-	-	HYPH
cord-262445-54ng7m92	126	7	HSS	HSS	NNP
cord-262445-54ng7m92	126	8	)	)	-RRB-
cord-262445-54ng7m92	126	9	,	,	.
cord-262445-54ng7m92	127	1	and	and	CC
cord-262445-54ng7m92	127	2	we	-PRON-	PRP
cord-262445-54ng7m92	127	3	observed	observe	VBD
cord-262445-54ng7m92	127	4	that	that	IN
cord-262445-54ng7m92	127	5	some	some	DT
cord-262445-54ng7m92	127	6	microRNAs	microRNAs	NNPS
cord-262445-54ng7m92	127	7	significantly	significantly	RB
cord-262445-54ng7m92	127	8	changed	change	VBD
cord-262445-54ng7m92	127	9	during	during	IN
cord-262445-54ng7m92	127	10	disease	disease	NN
cord-262445-54ng7m92	127	11	progression	progression	NN
cord-262445-54ng7m92	127	12	,	,	,
cord-262445-54ng7m92	127	13	while	while	IN
cord-262445-54ng7m92	127	14	the	the	DT
cord-262445-54ng7m92	127	15	others	other	NNS
cord-262445-54ng7m92	127	16	were	be	VBD
cord-262445-54ng7m92	127	17	good	good	JJ
cord-262445-54ng7m92	127	18	biomarkers	biomarker	NNS
cord-262445-54ng7m92	127	19	for	for	IN
cord-262445-54ng7m92	127	20	early	early	JJ
cord-262445-54ng7m92	127	21	and	and	CC
cord-262445-54ng7m92	127	22	late	late	JJ
cord-262445-54ng7m92	127	23	stages	stage	NNS
cord-262445-54ng7m92	127	24	of	of	IN
cord-262445-54ng7m92	127	25	the	the	DT
cord-262445-54ng7m92	127	26	disease	disease	NN
cord-262445-54ng7m92	127	27	.	.	.
cord-262445-54ng7m92	128	1	Furthermore	furthermore	RB
cord-262445-54ng7m92	128	2	,	,	,
cord-262445-54ng7m92	128	3	since	since	IN
cord-262445-54ng7m92	128	4	ALS	als	NN
cord-262445-54ng7m92	128	5	disease	disease	NN
cord-262445-54ng7m92	128	6	progression	progression	NN
cord-262445-54ng7m92	128	7	is	be	VBZ
cord-262445-54ng7m92	128	8	variable	variable	JJ
cord-262445-54ng7m92	128	9	in	in	IN
cord-262445-54ng7m92	128	10	terms	term	NNS
cord-262445-54ng7m92	128	11	of	of	IN
cord-262445-54ng7m92	128	12	velocity	velocity	NN
cord-262445-54ng7m92	128	13	and	and	CC
cord-262445-54ng7m92	128	14	aggressiveness	aggressiveness	NN
cord-262445-54ng7m92	128	15	,	,	,
cord-262445-54ng7m92	128	16	we	-PRON-	PRP
cord-262445-54ng7m92	128	17	divided	divide	VBD
cord-262445-54ng7m92	128	18	patients	patient	NNS
cord-262445-54ng7m92	128	19	cohort	cohort	JJ
cord-262445-54ng7m92	128	20	into	into	IN
cord-262445-54ng7m92	128	21	two	two	CD
cord-262445-54ng7m92	128	22	subgroups	subgroup	NNS
cord-262445-54ng7m92	128	23	with	with	IN
cord-262445-54ng7m92	128	24	a	a	DT
cord-262445-54ng7m92	128	25	different	different	JJ
cord-262445-54ng7m92	128	26	disease	disease	NN
cord-262445-54ng7m92	128	27	progression	progression	NN
cord-262445-54ng7m92	128	28	rate	rate	NN
cord-262445-54ng7m92	128	29	(	(	-LRB-
cord-262445-54ng7m92	128	30	slow	slow	JJ
cord-262445-54ng7m92	128	31	and	and	CC
cord-262445-54ng7m92	128	32	fast	fast	RB
cord-262445-54ng7m92	128	33	)	)	-RRB-
cord-262445-54ng7m92	128	34	,	,	,
cord-262445-54ng7m92	128	35	evaluated	evaluate	VBN
cord-262445-54ng7m92	128	36	by	by	IN
cord-262445-54ng7m92	128	37	ALS	ALS	NNP
cord-262445-54ng7m92	128	38	-Functional	-functional	CC
cord-262445-54ng7m92	128	39	Rating	rating	NN
cord-262445-54ng7m92	128	40	Scale	scale	NN
cord-262445-54ng7m92	128	41	(	(	-LRB-
cord-262445-54ng7m92	128	42	ALS	ALS	NNP
cord-262445-54ng7m92	128	43	-	-	HYPH
cord-262445-54ng7m92	128	44	FRS	FRS	NNP
cord-262445-54ng7m92	128	45	)	)	-RRB-
cord-262445-54ng7m92	128	46	.	.	.
cord-262445-54ng7m92	129	1	We	-PRON-	PRP
cord-262445-54ng7m92	129	2	identified	identify	VBD
cord-262445-54ng7m92	129	3	a	a	DT
cord-262445-54ng7m92	129	4	group	group	NN
cord-262445-54ng7m92	129	5	of	of	IN
cord-262445-54ng7m92	129	6	microRNAs	microRNAs	NNPS
cord-262445-54ng7m92	129	7	differentially	differentially	RB
cord-262445-54ng7m92	129	8	modulated	modulate	VBN
cord-262445-54ng7m92	129	9	in	in	IN
cord-262445-54ng7m92	129	10	slow	slow	JJ
cord-262445-54ng7m92	129	11	and	and	CC
cord-262445-54ng7m92	129	12	fast	fast	RB
cord-262445-54ng7m92	129	13	progressing	progress	VBG
cord-262445-54ng7m92	129	14	patients	patient	NNS
cord-262445-54ng7m92	129	15	,	,	,
cord-262445-54ng7m92	129	16	that	that	WDT
cord-262445-54ng7m92	129	17	resulted	result	VBD
cord-262445-54ng7m92	129	18	as	as	IN
cord-262445-54ng7m92	129	19	good	good	JJ
cord-262445-54ng7m92	129	20	prognostic	prognostic	JJ
cord-262445-54ng7m92	129	21	biomarkers	biomarker	NNS
cord-262445-54ng7m92	129	22	for	for	IN
cord-262445-54ng7m92	129	23	ALS	als	NN
cord-262445-54ng7m92	129	24	patients	patient	NNS
cord-262445-54ng7m92	129	25	at	at	IN
cord-262445-54ng7m92	129	26	the	the	DT
cord-262445-54ng7m92	129	27	moment	moment	NN
cord-262445-54ng7m92	129	28	of	of	IN
cord-262445-54ng7m92	129	29	the	the	DT
cord-262445-54ng7m92	129	30	diagnosis	diagnosis	NN
cord-262445-54ng7m92	129	31	.	.	.
cord-262445-54ng7m92	130	1	Overall	overall	RB
cord-262445-54ng7m92	130	2	the	the	DT
cord-262445-54ng7m92	130	3	results	result	NNS
cord-262445-54ng7m92	130	4	of	of	IN
cord-262445-54ng7m92	130	5	our	-PRON-	PRP$
cord-262445-54ng7m92	130	6	study	study	NN
cord-262445-54ng7m92	130	7	can	can	MD
cord-262445-54ng7m92	130	8	contribute	contribute	VB
cord-262445-54ng7m92	130	9	to	to	TO
cord-262445-54ng7m92	130	10	define	define	VB
cord-262445-54ng7m92	130	11	a	a	DT
cord-262445-54ng7m92	130	12	molecular	molecular	JJ
cord-262445-54ng7m92	130	13	signature	signature	NN
cord-262445-54ng7m92	130	14	of	of	IN
cord-262445-54ng7m92	130	15	ALS	als	NN
cord-262445-54ng7m92	130	16	phenotypes	phenotype	NNS
cord-262445-54ng7m92	130	17	,	,	,
cord-262445-54ng7m92	130	18	and	and	CC
cord-262445-54ng7m92	130	19	can	can	MD
cord-262445-54ng7m92	130	20	allow	allow	VB
cord-262445-54ng7m92	130	21	to	to	TO
cord-262445-54ng7m92	130	22	better	better	RB
cord-262445-54ng7m92	130	23	characterise	characterise	VB
cord-262445-54ng7m92	130	24	patients	patient	NNS
cord-262445-54ng7m92	130	25	to	to	TO
cord-262445-54ng7m92	130	26	enrol	enrol	VB
cord-262445-54ng7m92	130	27	in	in	IN
cord-262445-54ng7m92	130	28	clinical	clinical	JJ
cord-262445-54ng7m92	130	29	trials	trial	NNS
cord-262445-54ng7m92	130	30	.	.	.
cord-262445-54ng7m92	131	1	Exon	exon	NN
cord-262445-54ng7m92	131	2	skipping	skipping	NN
cord-262445-54ng7m92	131	3	is	be	VBZ
cord-262445-54ng7m92	131	4	one	one	CD
cord-262445-54ng7m92	131	5	of	of	IN
cord-262445-54ng7m92	131	6	the	the	DT
cord-262445-54ng7m92	131	7	promising	promising	JJ
cord-262445-54ng7m92	131	8	strategies	strategy	NNS
cord-262445-54ng7m92	131	9	to	to	TO
cord-262445-54ng7m92	131	10	treat	treat	VB
cord-262445-54ng7m92	131	11	Duchenne	Duchenne	NNP
cord-262445-54ng7m92	131	12	Muscular	muscular	JJ
cord-262445-54ng7m92	131	13	Dystrophy	Dystrophy	NNP
cord-262445-54ng7m92	131	14	.	.	.
cord-262445-54ng7m92	132	1	Recently	recently	RB
cord-262445-54ng7m92	132	2	we	-PRON-	PRP
cord-262445-54ng7m92	132	3	have	have	VBP
cord-262445-54ng7m92	132	4	studied	study	VBN
cord-262445-54ng7m92	132	5	the	the	DT
cord-262445-54ng7m92	132	6	case	case	NN
cord-262445-54ng7m92	132	7	of	of	IN
cord-262445-54ng7m92	132	8	a	a	DT
cord-262445-54ng7m92	132	9	Duchenne	Duchenne	NNP
cord-262445-54ng7m92	132	10	patient	patient	NN
cord-262445-54ng7m92	132	11	(	(	-LRB-
cord-262445-54ng7m92	132	12	GS44	GS44	NNP
cord-262445-54ng7m92	132	13	)	)	-RRB-
cord-262445-54ng7m92	132	14	characterized	characterize	VBN
cord-262445-54ng7m92	132	15	by	by	IN
cord-262445-54ng7m92	132	16	a	a	DT
cord-262445-54ng7m92	132	17	slower	slow	JJR
cord-262445-54ng7m92	132	18	progression	progression	NN
cord-262445-54ng7m92	132	19	of	of	IN
cord-262445-54ng7m92	132	20	the	the	DT
cord-262445-54ng7m92	132	21	pathology	pathology	NN
cord-262445-54ng7m92	132	22	and	and	CC
cord-262445-54ng7m92	132	23	healthier	healthy	JJR
cord-262445-54ng7m92	132	24	conditions	condition	NNS
cord-262445-54ng7m92	132	25	,	,	,
cord-262445-54ng7m92	132	26	if	if	IN
cord-262445-54ng7m92	132	27	compared	compare	VBN
cord-262445-54ng7m92	132	28	to	to	IN
cord-262445-54ng7m92	132	29	other	other	JJ
cord-262445-54ng7m92	132	30	age	age	NN
cord-262445-54ng7m92	132	31	-	-	HYPH
cord-262445-54ng7m92	132	32	matched	match	VBN
cord-262445-54ng7m92	132	33	Duchenne	Duchenne	NNP
cord-262445-54ng7m92	132	34	patients	patient	NNS
cord-262445-54ng7m92	132	35	.	.	.
cord-262445-54ng7m92	133	1	Studies	study	NNS
cord-262445-54ng7m92	133	2	in	in	IN
cord-262445-54ng7m92	133	3	our	-PRON-	PRP$
cord-262445-54ng7m92	133	4	lab	lab	NN
cord-262445-54ng7m92	133	5	revealed	reveal	VBD
cord-262445-54ng7m92	133	6	that	that	IN
cord-262445-54ng7m92	133	7	his	-PRON-	PRP$
cord-262445-54ng7m92	133	8	situation	situation	NN
cord-262445-54ng7m92	133	9	is	be	VBZ
cord-262445-54ng7m92	133	10	due	due	JJ
cord-262445-54ng7m92	133	11	to	to	IN
cord-262445-54ng7m92	133	12	a	a	DT
cord-262445-54ng7m92	133	13	natural	natural	JJ
cord-262445-54ng7m92	133	14	exon	exon	NN
cord-262445-54ng7m92	133	15	skipping	skip	VBG
cord-262445-54ng7m92	133	16	occurring	occur	VBG
cord-262445-54ng7m92	133	17	in	in	IN
cord-262445-54ng7m92	133	18	his	-PRON-	PRP$
cord-262445-54ng7m92	133	19	cells	cell	NNS
cord-262445-54ng7m92	133	20	.	.	.
cord-262445-54ng7m92	134	1	Briefly	briefly	RB
cord-262445-54ng7m92	134	2	,	,	,
cord-262445-54ng7m92	134	3	muscles	muscle	NNS
cord-262445-54ng7m92	134	4	of	of	IN
cord-262445-54ng7m92	134	5	this	this	DT
cord-262445-54ng7m92	134	6	subject	subject	JJ
cord-262445-54ng7m92	134	7	lack	lack	NN
cord-262445-54ng7m92	134	8	the	the	DT
cord-262445-54ng7m92	134	9	expression	expression	NN
cord-262445-54ng7m92	134	10	of	of	IN
cord-262445-54ng7m92	134	11	CELF2a	CELF2a	NNP
cord-262445-54ng7m92	134	12	splicing	splicing	NN
cord-262445-54ng7m92	134	13	enhancer	enhancer	NN
cord-262445-54ng7m92	134	14	.	.	.
cord-262445-54ng7m92	135	1	This	this	DT
cord-262445-54ng7m92	135	2	protein	protein	NN
cord-262445-54ng7m92	135	3	is	be	VBZ
cord-262445-54ng7m92	135	4	involved	involve	VBN
cord-262445-54ng7m92	135	5	in	in	IN
cord-262445-54ng7m92	135	6	splicing	splicing	NN
cord-262445-54ng7m92	135	7	of	of	IN
cord-262445-54ng7m92	135	8	exon	exon	NN
cord-262445-54ng7m92	135	9	45	45	CD
cord-262445-54ng7m92	135	10	,	,	,
cord-262445-54ng7m92	135	11	and	and	CC
cord-262445-54ng7m92	135	12	when	when	WRB
cord-262445-54ng7m92	135	13	is	be	VBZ
cord-262445-54ng7m92	135	14	absent	absent	JJ
cord-262445-54ng7m92	135	15	,	,	,
cord-262445-54ng7m92	135	16	like	like	IN
cord-262445-54ng7m92	135	17	in	in	IN
cord-262445-54ng7m92	135	18	GS44	GS44	NNP
cord-262445-54ng7m92	135	19	,	,	,
cord-262445-54ng7m92	135	20	this	this	DT
cord-262445-54ng7m92	135	21	exon	exon	NN
cord-262445-54ng7m92	135	22	is	be	VBZ
cord-262445-54ng7m92	135	23	n't	not	RB
cord-262445-54ng7m92	135	24	properly	properly	RB
cord-262445-54ng7m92	135	25	recognized	recognize	VBN
cord-262445-54ng7m92	135	26	and	and	CC
cord-262445-54ng7m92	135	27	,	,	,
cord-262445-54ng7m92	135	28	in	in	IN
cord-262445-54ng7m92	135	29	a	a	DT
cord-262445-54ng7m92	135	30	sub	sub	NN
cord-262445-54ng7m92	135	31	-	-	JJ
cord-262445-54ng7m92	135	32	population	population	NN
cord-262445-54ng7m92	135	33	of	of	IN
cord-262445-54ng7m92	135	34	Dystrophin	Dystrophin	NNP
cord-262445-54ng7m92	135	35	transcripts	transcript	NNS
cord-262445-54ng7m92	135	36	,	,	,
cord-262445-54ng7m92	135	37	is	be	VBZ
cord-262445-54ng7m92	135	38	skipped	skip	VBN
cord-262445-54ng7m92	135	39	.	.	.
cord-262445-54ng7m92	136	1	This	this	DT
cord-262445-54ng7m92	136	2	phenomenon	phenomenon	NN
cord-262445-54ng7m92	136	3	,	,	,
cord-262445-54ng7m92	136	4	in	in	IN
cord-262445-54ng7m92	136	5	a	a	DT
cord-262445-54ng7m92	136	6	DMD	DMD	NNP
cord-262445-54ng7m92	136	7	44	44	NNP
cord-262445-54ng7m92	136	8	context	context	NN
cord-262445-54ng7m92	136	9	,	,	,
cord-262445-54ng7m92	136	10	like	like	IN
cord-262445-54ng7m92	136	11	the	the	DT
cord-262445-54ng7m92	136	12	GS44	GS44	NNP
cord-262445-54ng7m92	136	13	one	one	CD
cord-262445-54ng7m92	136	14	,	,	,
cord-262445-54ng7m92	136	15	allows	allow	VBZ
cord-262445-54ng7m92	136	16	the	the	DT
cord-262445-54ng7m92	136	17	restoration	restoration	NN
cord-262445-54ng7m92	136	18	of	of	IN
cord-262445-54ng7m92	136	19	the	the	DT
cord-262445-54ng7m92	136	20	frame	frame	NN
cord-262445-54ng7m92	136	21	of	of	IN
cord-262445-54ng7m92	136	22	the	the	DT
cord-262445-54ng7m92	136	23	transcript	transcript	NN
cord-262445-54ng7m92	136	24	and	and	CC
cord-262445-54ng7m92	136	25	the	the	DT
cord-262445-54ng7m92	136	26	production	production	NN
cord-262445-54ng7m92	136	27	of	of	IN
cord-262445-54ng7m92	136	28	a	a	DT
cord-262445-54ng7m92	136	29	small	small	JJ
cord-262445-54ng7m92	136	30	amount	amount	NN
cord-262445-54ng7m92	136	31	of	of	IN
cord-262445-54ng7m92	136	32	the	the	DT
cord-262445-54ng7m92	136	33	Dystrophin	Dystrophin	NNP
cord-262445-54ng7m92	136	34	protein	protein	NN
cord-262445-54ng7m92	136	35	.	.	.
cord-262445-54ng7m92	137	1	Starting	start	VBG
cord-262445-54ng7m92	137	2	from	from	IN
cord-262445-54ng7m92	137	3	this	this	DT
cord-262445-54ng7m92	137	4	evidence	evidence	NN
cord-262445-54ng7m92	137	5	,	,	,
cord-262445-54ng7m92	137	6	it	-PRON-	PRP
cord-262445-54ng7m92	137	7	seemed	seem	VBD
cord-262445-54ng7m92	137	8	interesting	interesting	JJ
cord-262445-54ng7m92	137	9	to	to	TO
cord-262445-54ng7m92	137	10	deepen	deepen	VB
cord-262445-54ng7m92	137	11	the	the	DT
cord-262445-54ng7m92	137	12	study	study	NN
cord-262445-54ng7m92	137	13	of	of	IN
cord-262445-54ng7m92	137	14	the	the	DT
cord-262445-54ng7m92	137	15	regulation	regulation	NN
cord-262445-54ng7m92	137	16	of	of	IN
cord-262445-54ng7m92	137	17	this	this	DT
cord-262445-54ng7m92	137	18	protein	protein	NN
cord-262445-54ng7m92	137	19	since	since	IN
cord-262445-54ng7m92	137	20	its	-PRON-	PRP$
cord-262445-54ng7m92	137	21	inhibition	inhibition	NN
cord-262445-54ng7m92	137	22	could	could	MD
cord-262445-54ng7m92	137	23	be	be	VB
cord-262445-54ng7m92	137	24	a	a	DT
cord-262445-54ng7m92	137	25	treatment	treatment	NN
cord-262445-54ng7m92	137	26	for	for	IN
cord-262445-54ng7m92	137	27	those	those	DT
cord-262445-54ng7m92	137	28	patients	patient	NNS
cord-262445-54ng7m92	137	29	in	in	IN
cord-262445-54ng7m92	137	30	which	which	WDT
cord-262445-54ng7m92	137	31	the	the	DT
cord-262445-54ng7m92	137	32	skipping	skipping	NN
cord-262445-54ng7m92	137	33	of	of	IN
cord-262445-54ng7m92	137	34	exon	exon	NN
cord-262445-54ng7m92	137	35	45	45	CD
cord-262445-54ng7m92	137	36	could	could	MD
cord-262445-54ng7m92	137	37	recover	recover	VB
cord-262445-54ng7m92	137	38	the	the	DT
cord-262445-54ng7m92	137	39	Dystrophin	Dystrophin	NNP
cord-262445-54ng7m92	137	40	mRNA	mRNA	NNP
cord-262445-54ng7m92	137	41	frame	frame	NN
cord-262445-54ng7m92	137	42	.	.	.
cord-262445-54ng7m92	138	1	At	at	IN
cord-262445-54ng7m92	138	2	first	first	RB
cord-262445-54ng7m92	138	3	,	,	,
cord-262445-54ng7m92	138	4	we	-PRON-	PRP
cord-262445-54ng7m92	138	5	investigated	investigate	VBD
cord-262445-54ng7m92	138	6	the	the	DT
cord-262445-54ng7m92	138	7	reason	reason	NN
cord-262445-54ng7m92	138	8	of	of	IN
cord-262445-54ng7m92	138	9	the	the	DT
cord-262445-54ng7m92	138	10	absence	absence	NN
cord-262445-54ng7m92	138	11	of	of	IN
cord-262445-54ng7m92	138	12	the	the	DT
cord-262445-54ng7m92	138	13	protein	protein	NN
cord-262445-54ng7m92	138	14	in	in	IN
cord-262445-54ng7m92	138	15	this	this	DT
cord-262445-54ng7m92	138	16	individual	individual	NN
cord-262445-54ng7m92	138	17	.	.	.
cord-262445-54ng7m92	139	1	Genetic	genetic	JJ
cord-262445-54ng7m92	139	2	mutations	mutation	NNS
cord-262445-54ng7m92	139	3	were	be	VBD
cord-262445-54ng7m92	139	4	identified	identify	VBN
cord-262445-54ng7m92	139	5	nor	nor	CC
cord-262445-54ng7m92	139	6	in	in	IN
cord-262445-54ng7m92	139	7	the	the	DT
cord-262445-54ng7m92	139	8	promoter	promoter	NN
cord-262445-54ng7m92	139	9	neither	neither	CC
cord-262445-54ng7m92	139	10	in	in	IN
cord-262445-54ng7m92	139	11	the	the	DT
cord-262445-54ng7m92	139	12	coding	coding	NN
cord-262445-54ng7m92	139	13	sequence	sequence	NN
cord-262445-54ng7m92	139	14	.	.	.
cord-262445-54ng7m92	140	1	Moreover	moreover	RB
cord-262445-54ng7m92	140	2	,	,	,
cord-262445-54ng7m92	140	3	iPSC	iPSC	NNP
cord-262445-54ng7m92	140	4	derived	derive	VBN
cord-262445-54ng7m92	140	5	from	from	IN
cord-262445-54ng7m92	140	6	GS44	GS44	NNP
cord-262445-54ng7m92	140	7	fibroblasts	fibroblast	NNS
cord-262445-54ng7m92	140	8	and	and	CC
cord-262445-54ng7m92	140	9	differentiated	differentiate	VBN
cord-262445-54ng7m92	140	10	to	to	IN
cord-262445-54ng7m92	140	11	myotubes	myotubes	NNP
cord-262445-54ng7m92	140	12	,	,	,
cord-262445-54ng7m92	140	13	regain	regain	VB
cord-262445-54ng7m92	140	14	the	the	DT
cord-262445-54ng7m92	140	15	expression	expression	NN
cord-262445-54ng7m92	140	16	of	of	IN
cord-262445-54ng7m92	140	17	CELF2a	CELF2a	NNP
cord-262445-54ng7m92	140	18	.	.	.
cord-262445-54ng7m92	141	1	These	these	DT
cord-262445-54ng7m92	141	2	data	datum	NNS
cord-262445-54ng7m92	141	3	suggest	suggest	VBP
cord-262445-54ng7m92	141	4	that	that	IN
cord-262445-54ng7m92	141	5	an	an	DT
cord-262445-54ng7m92	141	6	aberrant	aberrant	JJ
cord-262445-54ng7m92	141	7	epigenetic	epigenetic	JJ
cord-262445-54ng7m92	141	8	control	control	NN
cord-262445-54ng7m92	141	9	does	do	VBZ
cord-262445-54ng7m92	141	10	n't	not	RB
cord-262445-54ng7m92	141	11	allow	allow	VB
cord-262445-54ng7m92	141	12	CELF2a	CELF2a	NNP
cord-262445-54ng7m92	141	13	expression	expression	NN
cord-262445-54ng7m92	141	14	in	in	IN
cord-262445-54ng7m92	141	15	the	the	DT
cord-262445-54ng7m92	141	16	patient	patient	NN
cord-262445-54ng7m92	141	17	.	.	.
cord-262445-54ng7m92	142	1	In	in	IN
cord-262445-54ng7m92	142	2	order	order	NN
cord-262445-54ng7m92	142	3	to	to	TO
cord-262445-54ng7m92	142	4	elucidate	elucidate	VB
cord-262445-54ng7m92	142	5	this	this	DT
cord-262445-54ng7m92	142	6	regulation	regulation	NN
cord-262445-54ng7m92	142	7	,	,	,
cord-262445-54ng7m92	142	8	we	-PRON-	PRP
cord-262445-54ng7m92	142	9	decided	decide	VBD
cord-262445-54ng7m92	142	10	to	to	TO
cord-262445-54ng7m92	142	11	perform	perform	VB
cord-262445-54ng7m92	142	12	ChIP	chip	NN
cord-262445-54ng7m92	142	13	-	-	HYPH
cord-262445-54ng7m92	142	14	seq	seq	NNP
cord-262445-54ng7m92	142	15	and	and	CC
cord-262445-54ng7m92	142	16	ATAC	ATAC	NNP
cord-262445-54ng7m92	142	17	-	-	HYPH
cord-262445-54ng7m92	142	18	seq	seq	NNP
cord-262445-54ng7m92	142	19	in	in	IN
cord-262445-54ng7m92	142	20	GS44	GS44	NNP
cord-262445-54ng7m92	142	21	versus	versus	IN
cord-262445-54ng7m92	142	22	control	control	NN
cord-262445-54ng7m92	142	23	myoblasts	myoblast	NNS
cord-262445-54ng7m92	142	24	.	.	.
cord-262445-54ng7m92	143	1	The	the	DT
cord-262445-54ng7m92	143	2	first	first	JJ
cord-262445-54ng7m92	143	3	was	be	VBD
cord-262445-54ng7m92	143	4	performed	perform	VBN
cord-262445-54ng7m92	143	5	to	to	TO
cord-262445-54ng7m92	143	6	study	study	VB
cord-262445-54ng7m92	143	7	common	common	JJ
cord-262445-54ng7m92	143	8	histones	histone	NNS
cord-262445-54ng7m92	143	9	modifications	modification	NNS
cord-262445-54ng7m92	143	10	,	,	,
cord-262445-54ng7m92	143	11	the	the	DT
cord-262445-54ng7m92	143	12	latter	latter	JJ
cord-262445-54ng7m92	143	13	to	to	TO
cord-262445-54ng7m92	143	14	take	take	VB
cord-262445-54ng7m92	143	15	a	a	DT
cord-262445-54ng7m92	143	16	snapshot	snapshot	NN
cord-262445-54ng7m92	143	17	of	of	IN
cord-262445-54ng7m92	143	18	the	the	DT
cord-262445-54ng7m92	143	19	genome	genome	NN
cord-262445-54ng7m92	143	20	wide	wide	JJ
cord-262445-54ng7m92	143	21	conformation	conformation	NN
cord-262445-54ng7m92	143	22	of	of	IN
cord-262445-54ng7m92	143	23	the	the	DT
cord-262445-54ng7m92	143	24	chromatin	chromatin	NN
cord-262445-54ng7m92	143	25	.	.	.
cord-262445-54ng7m92	144	1	In	in	IN
cord-262445-54ng7m92	144	2	this	this	DT
cord-262445-54ng7m92	144	3	way	way	NN
cord-262445-54ng7m92	144	4	we	-PRON-	PRP
cord-262445-54ng7m92	144	5	discriminate	discriminate	VBP
cord-262445-54ng7m92	144	6	loci	locus	NNS
cord-262445-54ng7m92	144	7	characterized	characterize	VBN
cord-262445-54ng7m92	144	8	by	by	IN
cord-262445-54ng7m92	144	9	opened	open	VBN
cord-262445-54ng7m92	144	10	and	and	CC
cord-262445-54ng7m92	144	11	actively	actively	RB
cord-262445-54ng7m92	144	12	transcribed	transcribe	VBN
cord-262445-54ng7m92	144	13	chromatin	chromatin	NN
cord-262445-54ng7m92	144	14	and	and	CC
cord-262445-54ng7m92	144	15	closed	closed	JJ
cord-262445-54ng7m92	144	16	and	and	CC
cord-262445-54ng7m92	144	17	inactive	inactive	JJ
cord-262445-54ng7m92	144	18	regions	region	NNS
cord-262445-54ng7m92	144	19	.	.	.
cord-262445-54ng7m92	145	1	CELF2a	CELF2a	NNP
cord-262445-54ng7m92	145	2	regulatory	regulatory	JJ
cord-262445-54ng7m92	145	3	region	region	NN
cord-262445-54ng7m92	145	4	is	be	VBZ
cord-262445-54ng7m92	145	5	marked	mark	VBN
cord-262445-54ng7m92	145	6	by	by	IN
cord-262445-54ng7m92	145	7	closed	closed	JJ
cord-262445-54ng7m92	145	8	chromatin	chromatin	NN
cord-262445-54ng7m92	145	9	and	and	CC
cord-262445-54ng7m92	145	10	repressive	repressive	JJ
cord-262445-54ng7m92	145	11	histone	histone	NN
cord-262445-54ng7m92	145	12	labels	label	NNS
cord-262445-54ng7m92	145	13	in	in	IN
cord-262445-54ng7m92	145	14	GS44	GS44	NNP
cord-262445-54ng7m92	145	15	(	(	-LRB-
cord-262445-54ng7m92	145	16	H3K27me3	H3K27me3	NNP
cord-262445-54ng7m92	145	17	)	)	-RRB-
cord-262445-54ng7m92	145	18	,	,	,
cord-262445-54ng7m92	145	19	while	while	IN
cord-262445-54ng7m92	145	20	in	in	IN
cord-262445-54ng7m92	145	21	control	control	NN
cord-262445-54ng7m92	145	22	is	be	VBZ
cord-262445-54ng7m92	145	23	open	open	JJ
cord-262445-54ng7m92	145	24	and	and	CC
cord-262445-54ng7m92	145	25	shows	show	VBZ
cord-262445-54ng7m92	145	26	histone	histone	NN
cord-262445-54ng7m92	145	27	modifications	modification	NNS
cord-262445-54ng7m92	145	28	that	that	WDT
cord-262445-54ng7m92	145	29	are	be	VBP
cord-262445-54ng7m92	145	30	usually	usually	RB
cord-262445-54ng7m92	145	31	enriched	enrich	VBN
cord-262445-54ng7m92	145	32	at	at	IN
cord-262445-54ng7m92	145	33	active	active	JJ
cord-262445-54ng7m92	145	34	chromatin	chromatin	NN
cord-262445-54ng7m92	145	35	regions	region	NNS
cord-262445-54ng7m92	145	36	(	(	-LRB-
cord-262445-54ng7m92	145	37	H3K4me3	H3K4me3	NNP
cord-262445-54ng7m92	145	38	and	and	CC
cord-262445-54ng7m92	145	39	H3K27ac	H3K27ac	NNP
cord-262445-54ng7m92	145	40	)	)	-RRB-
cord-262445-54ng7m92	145	41	,	,	,
cord-262445-54ng7m92	145	42	in	in	IN
cord-262445-54ng7m92	145	43	line	line	NN
cord-262445-54ng7m92	145	44	with	with	IN
cord-262445-54ng7m92	145	45	our	-PRON-	PRP$
cord-262445-54ng7m92	145	46	observations	observation	NNS
cord-262445-54ng7m92	145	47	.	.	.
cord-262445-54ng7m92	146	1	To	to	TO
cord-262445-54ng7m92	146	2	further	further	RB
cord-262445-54ng7m92	146	3	understand	understand	VB
cord-262445-54ng7m92	146	4	the	the	DT
cord-262445-54ng7m92	146	5	reason	reason	NN
cord-262445-54ng7m92	146	6	of	of	IN
cord-262445-54ng7m92	146	7	the	the	DT
cord-262445-54ng7m92	146	8	missing	missing	JJ
cord-262445-54ng7m92	146	9	expression	expression	NN
cord-262445-54ng7m92	146	10	of	of	IN
cord-262445-54ng7m92	146	11	CELF2a	CELF2a	NNP
cord-262445-54ng7m92	146	12	in	in	IN
cord-262445-54ng7m92	146	13	the	the	DT
cord-262445-54ng7m92	146	14	patient	patient	NN
cord-262445-54ng7m92	146	15	,	,	,
cord-262445-54ng7m92	146	16	RNA	RNA	NNP
cord-262445-54ng7m92	146	17	-	-	HYPH
cord-262445-54ng7m92	146	18	seq	seq	NNP
cord-262445-54ng7m92	146	19	analysis	analysis	NN
cord-262445-54ng7m92	146	20	was	be	VBD
cord-262445-54ng7m92	146	21	performed	perform	VBN
cord-262445-54ng7m92	146	22	on	on	IN
cord-262445-54ng7m92	146	23	GS44	GS44	NNP
cord-262445-54ng7m92	146	24	and	and	CC
cord-262445-54ng7m92	146	25	control	control	NN
cord-262445-54ng7m92	146	26	myoblasts	myoblast	NNS
cord-262445-54ng7m92	146	27	,	,	,
cord-262445-54ng7m92	146	28	in	in	IN
cord-262445-54ng7m92	146	29	order	order	NN
cord-262445-54ng7m92	146	30	to	to	TO
cord-262445-54ng7m92	146	31	find	find	VB
cord-262445-54ng7m92	146	32	a	a	DT
cord-262445-54ng7m92	146	33	regulator	regulator	NN
cord-262445-54ng7m92	146	34	of	of	IN
cord-262445-54ng7m92	146	35	the	the	DT
cord-262445-54ng7m92	146	36	factor	factor	NN
cord-262445-54ng7m92	146	37	.	.	.
cord-262445-54ng7m92	147	1	No	no	DT
cord-262445-54ng7m92	147	2	differences	difference	NNS
cord-262445-54ng7m92	147	3	in	in	IN
cord-262445-54ng7m92	147	4	transcription	transcription	NN
cord-262445-54ng7m92	147	5	factor	factor	NN
cord-262445-54ng7m92	147	6	expression	expression	NN
cord-262445-54ng7m92	147	7	,	,	,
cord-262445-54ng7m92	147	8	between	between	IN
cord-262445-54ng7m92	147	9	the	the	DT
cord-262445-54ng7m92	147	10	two	two	CD
cord-262445-54ng7m92	147	11	condition	condition	NN
cord-262445-54ng7m92	147	12	,	,	,
cord-262445-54ng7m92	147	13	were	be	VBD
cord-262445-54ng7m92	147	14	found	find	VBN
cord-262445-54ng7m92	147	15	.	.	.
cord-262445-54ng7m92	148	1	Instead	instead	RB
cord-262445-54ng7m92	148	2	we	-PRON-	PRP
cord-262445-54ng7m92	148	3	identified	identify	VBD
cord-262445-54ng7m92	148	4	some	some	DT
cord-262445-54ng7m92	148	5	long	long	JJ
cord-262445-54ng7m92	148	6	noncoding	noncoding	JJ
cord-262445-54ng7m92	148	7	differentially	differentially	RB
cord-262445-54ng7m92	148	8	expressed	express	VBN
cord-262445-54ng7m92	148	9	.	.	.
cord-262445-54ng7m92	149	1	Among	among	IN
cord-262445-54ng7m92	149	2	these	these	DT
cord-262445-54ng7m92	149	3	,	,	,
cord-262445-54ng7m92	149	4	one	one	CD
cord-262445-54ng7m92	149	5	is	be	VBZ
cord-262445-54ng7m92	149	6	particular	particular	RB
cord-262445-54ng7m92	149	7	interesting	interesting	JJ
cord-262445-54ng7m92	149	8	:	:	:
cord-262445-54ng7m92	149	9	some	some	DT
cord-262445-54ng7m92	149	10	experiments	experiment	NNS
cord-262445-54ng7m92	149	11	correlated	correlate	VBD
cord-262445-54ng7m92	149	12	its	-PRON-	PRP$
cord-262445-54ng7m92	149	13	presence	presence	NN
cord-262445-54ng7m92	149	14	in	in	IN
cord-262445-54ng7m92	149	15	the	the	DT
cord-262445-54ng7m92	149	16	patient	patient	NN
cord-262445-54ng7m92	149	17	to	to	IN
cord-262445-54ng7m92	149	18	the	the	DT
cord-262445-54ng7m92	149	19	absence	absence	NN
cord-262445-54ng7m92	149	20	of	of	IN
cord-262445-54ng7m92	149	21	CELF2a	CELF2a	NNP
cord-262445-54ng7m92	149	22	.	.	.
cord-262445-54ng7m92	150	1	We	-PRON-	PRP
cord-262445-54ng7m92	150	2	hypothesize	hypothesize	VBP
cord-262445-54ng7m92	150	3	that	that	IN
cord-262445-54ng7m92	150	4	this	this	DT
cord-262445-54ng7m92	150	5	long	long	JJ
cord-262445-54ng7m92	150	6	noncoding	noncoding	JJ
cord-262445-54ng7m92	150	7	could	could	MD
cord-262445-54ng7m92	150	8	repress	repress	VB
cord-262445-54ng7m92	150	9	CELF2a	CELF2a	NNP
cord-262445-54ng7m92	150	10	expression	expression	NN
cord-262445-54ng7m92	150	11	through	through	IN
cord-262445-54ng7m92	150	12	the	the	DT
cord-262445-54ng7m92	150	13	fine	fine	JJ
cord-262445-54ng7m92	150	14	-	-	HYPH
cord-262445-54ng7m92	150	15	tuning	tuning	NN
cord-262445-54ng7m92	150	16	of	of	IN
cord-262445-54ng7m92	150	17	chromatin	chromatin	NN
cord-262445-54ng7m92	150	18	accessibility	accessibility	NN
cord-262445-54ng7m92	150	19	.	.	.
cord-262445-54ng7m92	151	1	At	at	IN
cord-262445-54ng7m92	151	2	the	the	DT
cord-262445-54ng7m92	151	3	same	same	JJ
cord-262445-54ng7m92	151	4	time	time	NN
cord-262445-54ng7m92	151	5	,	,	,
cord-262445-54ng7m92	151	6	fibroblasts	fibroblast	NNS
cord-262445-54ng7m92	151	7	derived	derive	VBN
cord-262445-54ng7m92	151	8	from	from	IN
cord-262445-54ng7m92	151	9	a	a	DT
cord-262445-54ng7m92	151	10	44	44	NNP
cord-262445-54ng7m92	151	11	patient	patient	NN
cord-262445-54ng7m92	151	12	were	be	VBD
cord-262445-54ng7m92	151	13	reprogramed	reprogramed	JJ
cord-262445-54ng7m92	151	14	to	to	IN
cord-262445-54ng7m92	151	15	iPSC	iPSC	NNP
cord-262445-54ng7m92	151	16	and	and	CC
cord-262445-54ng7m92	151	17	clones	clone	NNS
cord-262445-54ng7m92	151	18	knock	knock	VBP
cord-262445-54ng7m92	151	19	out	out	RP
cord-262445-54ng7m92	151	20	for	for	IN
cord-262445-54ng7m92	151	21	CELF2a	CELF2a	NNP
cord-262445-54ng7m92	151	22	were	be	VBD
cord-262445-54ng7m92	151	23	obtained	obtain	VBN
cord-262445-54ng7m92	151	24	through	through	IN
cord-262445-54ng7m92	151	25	CRISPr	CRISPr	NNP
cord-262445-54ng7m92	151	26	/	/	SYM
cord-262445-54ng7m92	151	27	Cas9	Cas9	NNP
cord-262445-54ng7m92	151	28	technique	technique	NN
cord-262445-54ng7m92	151	29	.	.	.
cord-262445-54ng7m92	152	1	Interestingly	interestingly	RB
cord-262445-54ng7m92	152	2	these	these	DT
cord-262445-54ng7m92	152	3	clones	clone	NNS
cord-262445-54ng7m92	152	4	are	be	VBP
cord-262445-54ng7m92	152	5	able	able	JJ
cord-262445-54ng7m92	152	6	to	to	TO
cord-262445-54ng7m92	152	7	skip	skip	VB
cord-262445-54ng7m92	152	8	exon	exon	NN
cord-262445-54ng7m92	152	9	45	45	CD
cord-262445-54ng7m92	152	10	thus	thus	RB
cord-262445-54ng7m92	152	11	confirming	confirm	VBG
cord-262445-54ng7m92	152	12	the	the	DT
cord-262445-54ng7m92	152	13	therapeutical	therapeutical	JJ
cord-262445-54ng7m92	152	14	potential	potential	NN
cord-262445-54ng7m92	152	15	of	of	IN
cord-262445-54ng7m92	152	16	the	the	DT
cord-262445-54ng7m92	152	17	inhibition	inhibition	NN
cord-262445-54ng7m92	152	18	of	of	IN
cord-262445-54ng7m92	152	19	CELF2a	CELF2a	NNP
cord-262445-54ng7m92	152	20	.	.	.
cord-262445-54ng7m92	153	1	Histone	Histone	NNP
cord-262445-54ng7m92	153	2	deacetylase	deacetylase	NN
cord-262445-54ng7m92	153	3	4	4	CD
cord-262445-54ng7m92	154	1	(	(	-LRB-
cord-262445-54ng7m92	154	2	HDAC4	HDAC4	NNP
cord-262445-54ng7m92	154	3	)	)	-RRB-
cord-262445-54ng7m92	154	4	is	be	VBZ
cord-262445-54ng7m92	154	5	a	a	DT
cord-262445-54ng7m92	154	6	member	member	NN
cord-262445-54ng7m92	154	7	of	of	IN
cord-262445-54ng7m92	154	8	class	class	NN
cord-262445-54ng7m92	154	9	II	ii	NN
cord-262445-54ng7m92	154	10	HDACs	hdac	NNS
cord-262445-54ng7m92	154	11	which	which	WDT
cord-262445-54ng7m92	154	12	,	,	,
cord-262445-54ng7m92	154	13	by	by	IN
cord-262445-54ng7m92	154	14	cooperating	cooperate	VBG
cord-262445-54ng7m92	154	15	with	with	IN
cord-262445-54ng7m92	154	16	class	class	NN
cord-262445-54ng7m92	154	17	I	-PRON-	PRP
cord-262445-54ng7m92	154	18	HDACs	hdac	NNS
cord-262445-54ng7m92	154	19	,	,	,
cord-262445-54ng7m92	154	20	deacetylates	deacetylate	NNS
cord-262445-54ng7m92	154	21	proteins	protein	NNS
cord-262445-54ng7m92	154	22	,	,	,
cord-262445-54ng7m92	154	23	thereby	thereby	RB
cord-262445-54ng7m92	154	24	mediating	mediate	VBG
cord-262445-54ng7m92	154	25	the	the	DT
cord-262445-54ng7m92	154	26	response	response	NN
cord-262445-54ng7m92	154	27	to	to	IN
cord-262445-54ng7m92	154	28	different	different	JJ
cord-262445-54ng7m92	154	29	stimuli	stimulus	NNS
cord-262445-54ng7m92	154	30	in	in	IN
cord-262445-54ng7m92	154	31	skeletal	skeletal	JJ
cord-262445-54ng7m92	154	32	muscle	muscle	NN
cord-262445-54ng7m92	154	33	.	.	.
cord-262445-54ng7m92	155	1	Recently	recently	RB
cord-262445-54ng7m92	155	2	its	-PRON-	PRP$
cord-262445-54ng7m92	155	3	protective	protective	JJ
cord-262445-54ng7m92	155	4	,	,	,
cord-262445-54ng7m92	155	5	essential	essential	JJ
cord-262445-54ng7m92	155	6	role	role	NN
cord-262445-54ng7m92	155	7	in	in	IN
cord-262445-54ng7m92	155	8	maintaining	maintain	VBG
cord-262445-54ng7m92	155	9	skeletal	skeletal	JJ
cord-262445-54ng7m92	155	10	muscle	muscle	NN
cord-262445-54ng7m92	155	11	homeostasis	homeostasis	NN
cord-262445-54ng7m92	155	12	after	after	IN
cord-262445-54ng7m92	155	13	long	long	JJ
cord-262445-54ng7m92	155	14	-	-	HYPH
cord-262445-54ng7m92	155	15	term	term	NN
cord-262445-54ng7m92	155	16	denervation	denervation	NN
cord-262445-54ng7m92	155	17	(	(	-LRB-
cord-262445-54ng7m92	155	18	1	1	CD
cord-262445-54ng7m92	155	19	)	)	-RRB-
cord-262445-54ng7m92	155	20	or	or	CC
cord-262445-54ng7m92	155	21	in	in	IN
cord-262445-54ng7m92	155	22	Amyotrophic	Amyotrophic	NNP
cord-262445-54ng7m92	155	23	Lateral	Lateral	NNP
cord-262445-54ng7m92	155	24	Sclerosis	Sclerosis	NNP
cord-262445-54ng7m92	155	25	(	(	-LRB-
cord-262445-54ng7m92	155	26	2	2	CD
cord-262445-54ng7m92	155	27	)	)	-RRB-
cord-262445-54ng7m92	155	28	and	and	CC
cord-262445-54ng7m92	155	29	in	in	IN
cord-262445-54ng7m92	155	30	satellite	satellite	NN
cord-262445-54ng7m92	155	31	cell	cell	NN
cord-262445-54ng7m92	155	32	proliferation	proliferation	NN
cord-262445-54ng7m92	155	33	and	and	CC
cord-262445-54ng7m92	155	34	differentiation	differentiation	NN
cord-262445-54ng7m92	155	35	(	(	-LRB-
cord-262445-54ng7m92	155	36	3	3	CD
cord-262445-54ng7m92	155	37	)	)	-RRB-
cord-262445-54ng7m92	155	38	has	have	VBZ
cord-262445-54ng7m92	155	39	been	be	VBN
cord-262445-54ng7m92	155	40	clarified	clarify	VBN
cord-262445-54ng7m92	155	41	.	.	.
cord-262445-54ng7m92	156	1	Further	further	RB
cord-262445-54ng7m92	156	2	,	,	,
cord-262445-54ng7m92	156	3	HDAC4	HDAC4	NNP
cord-262445-54ng7m92	156	4	is	be	VBZ
cord-262445-54ng7m92	156	5	crucial	crucial	JJ
cord-262445-54ng7m92	156	6	for	for	IN
cord-262445-54ng7m92	156	7	skeletal	skeletal	JJ
cord-262445-54ng7m92	156	8	muscle	muscle	NN
cord-262445-54ng7m92	156	9	regeneration	regeneration	NN
cord-262445-54ng7m92	156	10	by	by	IN
cord-262445-54ng7m92	156	11	mediating	mediate	VBG
cord-262445-54ng7m92	156	12	soluble	soluble	JJ
cord-262445-54ng7m92	156	13	factors	factor	NNS
cord-262445-54ng7m92	156	14	that	that	WDT
cord-262445-54ng7m92	156	15	influence	influence	VBP
cord-262445-54ng7m92	156	16	musclederived	musclederived	JJ
cord-262445-54ng7m92	156	17	cell	cell	NN
cord-262445-54ng7m92	156	18	proliferation	proliferation	NN
cord-262445-54ng7m92	156	19	and	and	CC
cord-262445-54ng7m92	156	20	differentiation	differentiation	NN
cord-262445-54ng7m92	156	21	after	after	IN
cord-262445-54ng7m92	156	22	injury	injury	NN
cord-262445-54ng7m92	156	23	(	(	-LRB-
cord-262445-54ng7m92	156	24	4	4	CD
cord-262445-54ng7m92	156	25	)	)	-RRB-
cord-262445-54ng7m92	156	26	.	.	.
cord-262445-54ng7m92	157	1	Duchenne	Duchenne	NNP
cord-262445-54ng7m92	157	2	Muscular	Muscular	NNP
cord-262445-54ng7m92	157	3	Dystrophy	Dystrophy	NNP
cord-262445-54ng7m92	157	4	(	(	-LRB-
cord-262445-54ng7m92	157	5	DMD	DMD	NNP
cord-262445-54ng7m92	157	6	)	)	-RRB-
cord-262445-54ng7m92	157	7	is	be	VBZ
cord-262445-54ng7m92	157	8	a	a	DT
cord-262445-54ng7m92	157	9	fatal	fatal	JJ
cord-262445-54ng7m92	157	10	inherited	inherit	VBN
cord-262445-54ng7m92	157	11	muscle	muscle	NN
cord-262445-54ng7m92	157	12	-	-	HYPH
cord-262445-54ng7m92	157	13	wasting	waste	VBG
cord-262445-54ng7m92	157	14	disease	disease	NN
cord-262445-54ng7m92	157	15	,	,	,
cord-262445-54ng7m92	157	16	caused	cause	VBN
cord-262445-54ng7m92	157	17	by	by	IN
cord-262445-54ng7m92	157	18	mutations	mutation	NNS
cord-262445-54ng7m92	157	19	in	in	IN
cord-262445-54ng7m92	157	20	the	the	DT
cord-262445-54ng7m92	157	21	dystrophin	dystrophin	NN
cord-262445-54ng7m92	157	22	gene	gene	NN
cord-262445-54ng7m92	157	23	(	(	-LRB-
cord-262445-54ng7m92	157	24	5	5	CD
cord-262445-54ng7m92	157	25	)	)	-RRB-
cord-262445-54ng7m92	157	26	and	and	CC
cord-262445-54ng7m92	157	27	characterized	characterize	VBN
cord-262445-54ng7m92	157	28	by	by	IN
cord-262445-54ng7m92	157	29	progressive	progressive	JJ
cord-262445-54ng7m92	157	30	muscle	muscle	NN
cord-262445-54ng7m92	157	31	weakness	weakness	NN
cord-262445-54ng7m92	157	32	and	and	CC
cord-262445-54ng7m92	157	33	degeneration	degeneration	NN
cord-262445-54ng7m92	157	34	.	.	.
cord-262445-54ng7m92	158	1	The	the	DT
cord-262445-54ng7m92	158	2	membrane	membrane	NN
cord-262445-54ng7m92	158	3	repair	repair	NN
cord-262445-54ng7m92	158	4	response	response	NN
cord-262445-54ng7m92	158	5	,	,	,
cord-262445-54ng7m92	158	6	which	which	WDT
cord-262445-54ng7m92	158	7	involves	involve	VBZ
cord-262445-54ng7m92	158	8	multiple	multiple	JJ
cord-262445-54ng7m92	158	9	proteins	protein	NNS
cord-262445-54ng7m92	158	10	such	such	JJ
cord-262445-54ng7m92	158	11	as	as	IN
cord-262445-54ng7m92	158	12	dysferlin	dysferlin	NNP
cord-262445-54ng7m92	158	13	,	,	,
cord-262445-54ng7m92	158	14	MG53	MG53	NNP
cord-262445-54ng7m92	158	15	and	and	CC
cord-262445-54ng7m92	158	16	Annexin	Annexin	NNP
cord-262445-54ng7m92	158	17	1	1	CD
cord-262445-54ng7m92	158	18	,	,	,
cord-262445-54ng7m92	158	19	is	be	VBZ
cord-262445-54ng7m92	158	20	enhanced	enhance	VBN
cord-262445-54ng7m92	158	21	to	to	TO
cord-262445-54ng7m92	158	22	actively	actively	RB
cord-262445-54ng7m92	158	23	maintain	maintain	VB
cord-262445-54ng7m92	158	24	membrane	membrane	NN
cord-262445-54ng7m92	158	25	integrity	integrity	NN
cord-262445-54ng7m92	158	26	in	in	IN
cord-262445-54ng7m92	158	27	DMD	DMD	NNP
cord-262445-54ng7m92	158	28	(	(	-LRB-
cord-262445-54ng7m92	158	29	6	6	CD
cord-262445-54ng7m92	158	30	)	)	-RRB-
cord-262445-54ng7m92	158	31	.	.	.
cord-262445-54ng7m92	159	1	The	the	DT
cord-262445-54ng7m92	159	2	pan	pan	JJ
cord-262445-54ng7m92	159	3	-	-	JJ
cord-262445-54ng7m92	159	4	HDAC	HDAC	NNP
cord-262445-54ng7m92	159	5	inhibitor	inhibitor	NN
cord-262445-54ng7m92	159	6	givinostat	givinostat	NN
cord-262445-54ng7m92	159	7	is	be	VBZ
cord-262445-54ng7m92	159	8	presently	presently	RB
cord-262445-54ng7m92	159	9	in	in	IN
cord-262445-54ng7m92	159	10	phase	phase	NN
cord-262445-54ng7m92	159	11	III	iii	CD
cord-262445-54ng7m92	159	12	clinical	clinical	JJ
cord-262445-54ng7m92	159	13	trial	trial	NN
cord-262445-54ng7m92	159	14	for	for	IN
cord-262445-54ng7m92	159	15	the	the	DT
cord-262445-54ng7m92	159	16	treatment	treatment	NN
cord-262445-54ng7m92	159	17	of	of	IN
cord-262445-54ng7m92	159	18	DMD	DMD	NNP
cord-262445-54ng7m92	159	19	,	,	,
cord-262445-54ng7m92	159	20	despite	despite	IN
cord-262445-54ng7m92	159	21	no	no	DT
cord-262445-54ng7m92	159	22	efficacy	efficacy	NN
cord-262445-54ng7m92	159	23	in	in	IN
cord-262445-54ng7m92	159	24	skeletal	skeletal	JJ
cord-262445-54ng7m92	159	25	muscle	muscle	NN
cord-262445-54ng7m92	159	26	function	function	NN
cord-262445-54ng7m92	159	27	has	have	VBZ
cord-262445-54ng7m92	159	28	been	be	VBN
cord-262445-54ng7m92	159	29	registered	register	VBN
cord-262445-54ng7m92	159	30	in	in	IN
cord-262445-54ng7m92	159	31	DMD	DMD	NNP
cord-262445-54ng7m92	159	32	patients	patient	NNS
cord-262445-54ng7m92	159	33	(	(	-LRB-
cord-262445-54ng7m92	159	34	7	7	CD
cord-262445-54ng7m92	159	35	)	)	-RRB-
cord-262445-54ng7m92	159	36	,	,	,
cord-262445-54ng7m92	159	37	highlighting	highlight	VBG
cord-262445-54ng7m92	159	38	the	the	DT
cord-262445-54ng7m92	159	39	needs	need	NNS
cord-262445-54ng7m92	159	40	to	to	TO
cord-262445-54ng7m92	159	41	study	study	VB
cord-262445-54ng7m92	159	42	the	the	DT
cord-262445-54ng7m92	159	43	HDAC	HDAC	NNP
cord-262445-54ng7m92	159	44	functions	function	NNS
cord-262445-54ng7m92	159	45	in	in	IN
cord-262445-54ng7m92	159	46	skeletal	skeletal	JJ
cord-262445-54ng7m92	159	47	muscle	muscle	NN
cord-262445-54ng7m92	159	48	in	in	IN
cord-262445-54ng7m92	159	49	DMD	DMD	NNP
cord-262445-54ng7m92	159	50	further	further	RB
cord-262445-54ng7m92	159	51	.	.	.
cord-262445-54ng7m92	160	1	While	while	IN
cord-262445-54ng7m92	160	2	the	the	DT
cord-262445-54ng7m92	160	3	function	function	NN
cord-262445-54ng7m92	160	4	of	of	IN
cord-262445-54ng7m92	160	5	class	class	NN
cord-262445-54ng7m92	160	6	I	-PRON-	PRP
cord-262445-54ng7m92	160	7	HDACs	hdac	VBZ
cord-262445-54ng7m92	160	8	in	in	IN
cord-262445-54ng7m92	160	9	DMD	DMD	NNP
cord-262445-54ng7m92	160	10	has	have	VBZ
cord-262445-54ng7m92	160	11	been	be	VBN
cord-262445-54ng7m92	160	12	partially	partially	RB
cord-262445-54ng7m92	160	13	elucidated	elucidate	VBN
cord-262445-54ng7m92	160	14	(	(	-LRB-
cord-262445-54ng7m92	160	15	8)	8)	NN
cord-262445-54ng7m92	160	16	,	,	,
cord-262445-54ng7m92	160	17	little	little	JJ
cord-262445-54ng7m92	160	18	is	be	VBZ
cord-262445-54ng7m92	160	19	known	know	VBN
cord-262445-54ng7m92	160	20	about	about	IN
cord-262445-54ng7m92	160	21	the	the	DT
cord-262445-54ng7m92	160	22	role	role	NN
cord-262445-54ng7m92	160	23	of	of	IN
cord-262445-54ng7m92	160	24	class	class	NN
cord-262445-54ng7m92	160	25	II	ii	NN
cord-262445-54ng7m92	160	26	HDACs	hdac	NNS
cord-262445-54ng7m92	160	27	.	.	.
cord-262445-54ng7m92	161	1	To	to	TO
cord-262445-54ng7m92	161	2	shed	shed	VB
cord-262445-54ng7m92	161	3	light	light	NN
cord-262445-54ng7m92	161	4	on	on	IN
cord-262445-54ng7m92	161	5	additional	additional	JJ
cord-262445-54ng7m92	161	6	functions	function	NNS
cord-262445-54ng7m92	161	7	of	of	IN
cord-262445-54ng7m92	161	8	HDAC4	hdac4	NN
cord-262445-54ng7m92	161	9	in	in	IN
cord-262445-54ng7m92	161	10	skeletal	skeletal	JJ
cord-262445-54ng7m92	161	11	muscle	muscle	NN
cord-262445-54ng7m92	161	12	,	,	,
cord-262445-54ng7m92	161	13	we	-PRON-	PRP
cord-262445-54ng7m92	161	14	are	be	VBP
cord-262445-54ng7m92	161	15	currently	currently	RB
cord-262445-54ng7m92	161	16	studying	study	VBG
cord-262445-54ng7m92	161	17	the	the	DT
cord-262445-54ng7m92	161	18	role	role	NN
cord-262445-54ng7m92	161	19	of	of	IN
cord-262445-54ng7m92	161	20	HDAC4	HDAC4	NNP
cord-262445-54ng7m92	161	21	in	in	IN
cord-262445-54ng7m92	161	22	DMD	DMD	NNP
cord-262445-54ng7m92	161	23	by	by	IN
cord-262445-54ng7m92	161	24	using	use	VBG
cord-262445-54ng7m92	161	25	a	a	DT
cord-262445-54ng7m92	161	26	genetic	genetic	JJ
cord-262445-54ng7m92	161	27	approach	approach	NN
cord-262445-54ng7m92	161	28	.	.	.
cord-262445-54ng7m92	162	1	We	-PRON-	PRP
cord-262445-54ng7m92	162	2	generated	generate	VBD
cord-262445-54ng7m92	162	3	DMD	DMD	NNP
cord-262445-54ng7m92	162	4	mice	mouse	NNS
cord-262445-54ng7m92	162	5	with	with	IN
cord-262445-54ng7m92	162	6	HDAC4	HDAC4	NNS
cord-262445-54ng7m92	162	7	deleted	delete	VBN
cord-262445-54ng7m92	162	8	in	in	IN
cord-262445-54ng7m92	162	9	skeletal	skeletal	JJ
cord-262445-54ng7m92	162	10	muscle	muscle	NN
cord-262445-54ng7m92	162	11	(	(	-LRB-
cord-262445-54ng7m92	162	12	mdx;HDAC4mKO	mdx;hdac4mko	NN
cord-262445-54ng7m92	162	13	)	)	-RRB-
cord-262445-54ng7m92	162	14	,	,	,
cord-262445-54ng7m92	162	15	by	by	IN
cord-262445-54ng7m92	162	16	crossing	cross	VBG
cord-262445-54ng7m92	162	17	mice	mouse	NNS
cord-262445-54ng7m92	162	18	with	with	IN
cord-262445-54ng7m92	162	19	a	a	DT
cord-262445-54ng7m92	162	20	skeletal	skeletal	JJ
cord-262445-54ng7m92	162	21	muscle	muscle	NN
cord-262445-54ng7m92	162	22	-	-	HYPH
cord-262445-54ng7m92	162	23	specific	specific	JJ
cord-262445-54ng7m92	162	24	deletion	deletion	NN
cord-262445-54ng7m92	162	25	of	of	IN
cord-262445-54ng7m92	162	26	HDAC4	HDAC4	NNP
cord-262445-54ng7m92	162	27	(	(	-LRB-
cord-262445-54ng7m92	162	28	HDAC4	HDAC4	NNP
cord-262445-54ng7m92	162	29	mKO	mKO	NNP
cord-262445-54ng7m92	162	30	)	)	-RRB-
cord-262445-54ng7m92	162	31	with	with	IN
cord-262445-54ng7m92	162	32	mdx	mdx	NNP
cord-262445-54ng7m92	162	33	mice	mouse	NNS
cord-262445-54ng7m92	162	34	,	,	,
cord-262445-54ng7m92	162	35	a	a	DT
cord-262445-54ng7m92	162	36	mouse	mouse	NN
cord-262445-54ng7m92	162	37	model	model	NN
cord-262445-54ng7m92	162	38	of	of	IN
cord-262445-54ng7m92	162	39	DMD	DMD	NNP
cord-262445-54ng7m92	162	40	.	.	.
cord-262445-54ng7m92	163	1	To	to	TO
cord-262445-54ng7m92	163	2	determine	determine	VB
cord-262445-54ng7m92	163	3	HDAC4	HDAC4	NNP
cord-262445-54ng7m92	163	4	functions	function	NNS
cord-262445-54ng7m92	163	5	,	,	,
cord-262445-54ng7m92	163	6	muscular	muscular	JJ
cord-262445-54ng7m92	163	7	dystrophy	dystrophy	NN
cord-262445-54ng7m92	163	8	progression	progression	NN
cord-262445-54ng7m92	163	9	has	have	VBZ
cord-262445-54ng7m92	163	10	been	be	VBN
cord-262445-54ng7m92	163	11	analyzed	analyze	VBN
cord-262445-54ng7m92	163	12	over	over	IN
cord-262445-54ng7m92	163	13	time	time	NN
cord-262445-54ng7m92	163	14	,	,	,
cord-262445-54ng7m92	163	15	by	by	IN
cord-262445-54ng7m92	163	16	histological	histological	JJ
cord-262445-54ng7m92	163	17	and	and	CC
cord-262445-54ng7m92	163	18	functional	functional	JJ
cord-262445-54ng7m92	163	19	analyses	analysis	NNS
cord-262445-54ng7m92	163	20	.	.	.
cord-262445-54ng7m92	164	1	The	the	DT
cord-262445-54ng7m92	164	2	deletion	deletion	NN
cord-262445-54ng7m92	164	3	of	of	IN
cord-262445-54ng7m92	164	4	HDAC4	hdac4	NN
cord-262445-54ng7m92	164	5	in	in	IN
cord-262445-54ng7m92	164	6	skeletal	skeletal	JJ
cord-262445-54ng7m92	164	7	muscles	muscle	NNS
cord-262445-54ng7m92	164	8	exacerbates	exacerbate	VBZ
cord-262445-54ng7m92	164	9	muscle	muscle	NN
cord-262445-54ng7m92	164	10	degeneration	degeneration	NN
cord-262445-54ng7m92	164	11	,	,	,
cord-262445-54ng7m92	164	12	increases	increase	VBZ
cord-262445-54ng7m92	164	13	circulating	circulate	VBG
cord-262445-54ng7m92	164	14	creatine	creatine	NN
cord-262445-54ng7m92	164	15	kinase	kinase	NN
cord-262445-54ng7m92	164	16	levels	level	NNS
cord-262445-54ng7m92	164	17	and	and	CC
cord-262445-54ng7m92	164	18	decreases	decrease	VBZ
cord-262445-54ng7m92	164	19	muscle	muscle	NN
cord-262445-54ng7m92	164	20	functionality	functionality	NN
cord-262445-54ng7m92	164	21	over	over	IN
cord-262445-54ng7m92	164	22	time	time	NN
cord-262445-54ng7m92	164	23	.	.	.
cord-262445-54ng7m92	165	1	Further	further	JJ
cord-262445-54ng7m92	165	2	investigations	investigation	NNS
cord-262445-54ng7m92	165	3	have	have	VBP
cord-262445-54ng7m92	165	4	highlighted	highlight	VBN
cord-262445-54ng7m92	165	5	an	an	DT
cord-262445-54ng7m92	165	6	impaired	impaired	JJ
cord-262445-54ng7m92	165	7	membrane	membrane	NN
cord-262445-54ng7m92	165	8	repair	repair	NN
cord-262445-54ng7m92	165	9	mechanism	mechanism	NN
cord-262445-54ng7m92	165	10	in	in	IN
cord-262445-54ng7m92	165	11	mdx;HDAC4mKO	mdx;hdac4mko	NN
cord-262445-54ng7m92	165	12	mice	mouse	NNS
cord-262445-54ng7m92	165	13	that	that	WDT
cord-262445-54ng7m92	165	14	may	may	MD
cord-262445-54ng7m92	165	15	underpin	underpin	VB
cord-262445-54ng7m92	165	16	the	the	DT
cord-262445-54ng7m92	165	17	more	more	RBR
cord-262445-54ng7m92	165	18	pronounced	pronounced	JJ
cord-262445-54ng7m92	165	19	progression	progression	NN
cord-262445-54ng7m92	165	20	of	of	IN
cord-262445-54ng7m92	165	21	the	the	DT
cord-262445-54ng7m92	165	22	pathology	pathology	NN
cord-262445-54ng7m92	165	23	.	.	.
cord-262445-54ng7m92	166	1	From	from	IN
cord-262445-54ng7m92	166	2	our	-PRON-	PRP$
cord-262445-54ng7m92	166	3	results	result	NNS
cord-262445-54ng7m92	166	4	,	,	,
cord-262445-54ng7m92	166	5	we	-PRON-	PRP
cord-262445-54ng7m92	166	6	conclude	conclude	VBP
cord-262445-54ng7m92	166	7	that	that	IN
cord-262445-54ng7m92	166	8	HDAC4	HDAC4	NNP
cord-262445-54ng7m92	166	9	is	be	VBZ
cord-262445-54ng7m92	166	10	important	important	JJ
cord-262445-54ng7m92	166	11	for	for	IN
cord-262445-54ng7m92	166	12	maintaining	maintain	VBG
cord-262445-54ng7m92	166	13	skeletal	skeletal	JJ
cord-262445-54ng7m92	166	14	muscle	muscle	NN
cord-262445-54ng7m92	166	15	integrity	integrity	NN
cord-262445-54ng7m92	166	16	in	in	IN
cord-262445-54ng7m92	166	17	DMD	DMD	NNP
cord-262445-54ng7m92	166	18	mice	mouse	NNS
cord-262445-54ng7m92	166	19	.	.	.
cord-262445-54ng7m92	167	1	Ongoing	ongoing	JJ
cord-262445-54ng7m92	167	2	studies	study	NNS
cord-262445-54ng7m92	167	3	are	be	VBP
cord-262445-54ng7m92	167	4	necessary	necessary	JJ
cord-262445-54ng7m92	167	5	to	to	TO
cord-262445-54ng7m92	167	6	define	define	VB
cord-262445-54ng7m92	167	7	the	the	DT
cord-262445-54ng7m92	167	8	molecular	molecular	JJ
cord-262445-54ng7m92	167	9	signaling	signaling	NN
cord-262445-54ng7m92	167	10	modulated	modulate	VBN
cord-262445-54ng7m92	167	11	by	by	IN
cord-262445-54ng7m92	167	12	HDAC4	HDAC4	NNP
cord-262445-54ng7m92	167	13	in	in	IN
cord-262445-54ng7m92	167	14	DMD	DMD	NNP
cord-262445-54ng7m92	167	15	in	in	IN
cord-262445-54ng7m92	167	16	order	order	NN
cord-262445-54ng7m92	167	17	to	to	TO
cord-262445-54ng7m92	167	18	provide	provide	VB
cord-262445-54ng7m92	167	19	the	the	DT
cord-262445-54ng7m92	167	20	experimental	experimental	JJ
cord-262445-54ng7m92	167	21	basis	basis	NN
cord-262445-54ng7m92	167	22	for	for	IN
cord-262445-54ng7m92	167	23	a	a	DT
cord-262445-54ng7m92	167	24	more	more	RBR
cord-262445-54ng7m92	167	25	efficacious	efficacious	JJ
cord-262445-54ng7m92	167	26	pharmacological	pharmacological	JJ
cord-262445-54ng7m92	167	27	therapy	therapy	NN
cord-262445-54ng7m92	167	28	.	.	.
cord-262445-54ng7m92	168	1	Cerebral	cerebral	JJ
cord-262445-54ng7m92	168	2	palsy	palsy	NN
cord-262445-54ng7m92	168	3	(	(	-LRB-
cord-262445-54ng7m92	168	4	CP	CP	NNP
cord-262445-54ng7m92	168	5	)	)	-RRB-
cord-262445-54ng7m92	168	6	is	be	VBZ
cord-262445-54ng7m92	168	7	the	the	DT
cord-262445-54ng7m92	168	8	single	single	JJ
cord-262445-54ng7m92	168	9	largest	large	JJS
cord-262445-54ng7m92	168	10	condition	condition	NN
cord-262445-54ng7m92	168	11	leading	lead	VBG
cord-262445-54ng7m92	168	12	to	to	IN
cord-262445-54ng7m92	168	13	childhood	childhood	NN
cord-262445-54ng7m92	168	14	physical	physical	JJ
cord-262445-54ng7m92	168	15	disability	disability	NN
cord-262445-54ng7m92	168	16	.	.	.
cord-262445-54ng7m92	169	1	This	this	DT
cord-262445-54ng7m92	169	2	neurodevelopmental	neurodevelopmental	JJ
cord-262445-54ng7m92	169	3	disorder	disorder	NN
cord-262445-54ng7m92	169	4	is	be	VBZ
cord-262445-54ng7m92	169	5	characterized	characterize	VBN
cord-262445-54ng7m92	169	6	primarily	primarily	RB
cord-262445-54ng7m92	169	7	by	by	IN
cord-262445-54ng7m92	169	8	neural	neural	JJ
cord-262445-54ng7m92	169	9	deficits	deficit	NNS
cord-262445-54ng7m92	169	10	caused	cause	VBN
cord-262445-54ng7m92	169	11	by	by	IN
cord-262445-54ng7m92	169	12	a	a	DT
cord-262445-54ng7m92	169	13	non	non	JJ
cord-262445-54ng7m92	169	14	-	-	JJ
cord-262445-54ng7m92	169	15	progressive	progressive	JJ
cord-262445-54ng7m92	169	16	lesion	lesion	NN
cord-262445-54ng7m92	169	17	in	in	IN
cord-262445-54ng7m92	169	18	the	the	DT
cord-262445-54ng7m92	169	19	immature	immature	JJ
cord-262445-54ng7m92	169	20	brain	brain	NN
cord-262445-54ng7m92	169	21	,	,	,
cord-262445-54ng7m92	169	22	and	and	CC
cord-262445-54ng7m92	169	23	secondly	secondly	RB
cord-262445-54ng7m92	169	24	by	by	IN
cord-262445-54ng7m92	169	25	musculoskeletal	musculoskeletal	JJ
cord-262445-54ng7m92	169	26	problems	problem	NNS
cord-262445-54ng7m92	169	27	that	that	WDT
cord-262445-54ng7m92	169	28	progress	progress	VBP
cord-262445-54ng7m92	169	29	with	with	IN
cord-262445-54ng7m92	169	30	age	age	NN
cord-262445-54ng7m92	169	31	.	.	.
cord-262445-54ng7m92	170	1	Alterations	alteration	NNS
cord-262445-54ng7m92	170	2	at	at	IN
cord-262445-54ng7m92	170	3	the	the	DT
cord-262445-54ng7m92	170	4	level	level	NN
cord-262445-54ng7m92	170	5	of	of	IN
cord-262445-54ng7m92	170	6	the	the	DT
cord-262445-54ng7m92	170	7	muscle	muscle	NN
cord-262445-54ng7m92	170	8	have	have	VBP
cord-262445-54ng7m92	170	9	been	be	VBN
cord-262445-54ng7m92	170	10	observed	observe	VBN
cord-262445-54ng7m92	170	11	in	in	IN
cord-262445-54ng7m92	170	12	comparison	comparison	NN
cord-262445-54ng7m92	170	13	to	to	IN
cord-262445-54ng7m92	170	14	normal	normal	JJ
cord-262445-54ng7m92	170	15	developing	develop	VBG
cord-262445-54ng7m92	170	16	children	child	NNS
cord-262445-54ng7m92	170	17	on	on	IN
cord-262445-54ng7m92	170	18	both	both	DT
cord-262445-54ng7m92	170	19	macroscopic	macroscopic	JJ
cord-262445-54ng7m92	170	20	(	(	-LRB-
cord-262445-54ng7m92	170	21	e.g.	e.g.	RB
cord-262445-54ng7m92	170	22	reduced	reduce	VBN
cord-262445-54ng7m92	170	23	muscle	muscle	NN
cord-262445-54ng7m92	170	24	volume	volume	NN
cord-262445-54ng7m92	170	25	,	,	,
cord-262445-54ng7m92	170	26	shorter	short	JJR
cord-262445-54ng7m92	170	27	muscle	muscle	NN
cord-262445-54ng7m92	170	28	belly	belly	NN
cord-262445-54ng7m92	170	29	,	,	,
cord-262445-54ng7m92	170	30	longer	long	JJR
cord-262445-54ng7m92	170	31	tendons	tendon	NNS
cord-262445-54ng7m92	170	32	)	)	-RRB-
cord-262445-54ng7m92	170	33	and	and	CC
cord-262445-54ng7m92	170	34	microscopic	microscopic	JJ
cord-262445-54ng7m92	170	35	(	(	-LRB-
cord-262445-54ng7m92	170	36	e.g.	e.g.	IN
cord-262445-54ng7m92	170	37	hypertrophic	hypertrophic	JJ
cord-262445-54ng7m92	170	38	extracellular	extracellular	JJ
cord-262445-54ng7m92	170	39	matrix	matrix	NN
cord-262445-54ng7m92	170	40	and	and	CC
cord-262445-54ng7m92	170	41	fibrotic	fibrotic	JJ
cord-262445-54ng7m92	170	42	tissue	tissue	NN
cord-262445-54ng7m92	170	43	accumulation	accumulation	NN
cord-262445-54ng7m92	170	44	)	)	-RRB-
cord-262445-54ng7m92	170	45	levels	level	NNS
cord-262445-54ng7m92	170	46	.	.	.
cord-262445-54ng7m92	171	1	Unfortunately	unfortunately	RB
cord-262445-54ng7m92	171	2	,	,	,
cord-262445-54ng7m92	171	3	the	the	DT
cord-262445-54ng7m92	171	4	onset	onset	NN
cord-262445-54ng7m92	171	5	and	and	CC
cord-262445-54ng7m92	171	6	the	the	DT
cord-262445-54ng7m92	171	7	development	development	NN
cord-262445-54ng7m92	171	8	of	of	IN
cord-262445-54ng7m92	171	9	these	these	DT
cord-262445-54ng7m92	171	10	muscle	muscle	NN
cord-262445-54ng7m92	171	11	alterations	alteration	NNS
cord-262445-54ng7m92	171	12	are	be	VBP
cord-262445-54ng7m92	171	13	not	not	RB
cord-262445-54ng7m92	171	14	well	well	RB
cord-262445-54ng7m92	171	15	understood	understand	VBN
cord-262445-54ng7m92	171	16	,	,	,
cord-262445-54ng7m92	171	17	since	since	IN
cord-262445-54ng7m92	171	18	data	datum	NNS
cord-262445-54ng7m92	171	19	on	on	IN
cord-262445-54ng7m92	171	20	young	young	JJ
cord-262445-54ng7m92	171	21	CP	cp	NN
cord-262445-54ng7m92	171	22	patients	patient	NNS
cord-262445-54ng7m92	171	23	are	be	VBP
cord-262445-54ng7m92	171	24	still	still	RB
cord-262445-54ng7m92	171	25	lacking	lack	VBG
cord-262445-54ng7m92	171	26	.	.	.
cord-262445-54ng7m92	172	1	The	the	DT
cord-262445-54ng7m92	172	2	skeletal	skeletal	JJ
cord-262445-54ng7m92	172	3	muscle	muscle	NN
cord-262445-54ng7m92	172	4	is	be	VBZ
cord-262445-54ng7m92	172	5	a	a	DT
cord-262445-54ng7m92	172	6	highly	highly	RB
cord-262445-54ng7m92	172	7	dynamic	dynamic	JJ
cord-262445-54ng7m92	172	8	tissue	tissue	NN
cord-262445-54ng7m92	172	9	and	and	CC
cord-262445-54ng7m92	172	10	resident	resident	NN
cord-262445-54ng7m92	172	11	stem	stem	NN
cord-262445-54ng7m92	172	12	cells	cell	NNS
cord-262445-54ng7m92	172	13	are	be	VBP
cord-262445-54ng7m92	172	14	the	the	DT
cord-262445-54ng7m92	172	15	postnatal	postnatal	JJ
cord-262445-54ng7m92	172	16	actors	actor	NNS
cord-262445-54ng7m92	172	17	of	of	IN
cord-262445-54ng7m92	172	18	repair	repair	NN
cord-262445-54ng7m92	172	19	and	and	CC
cord-262445-54ng7m92	172	20	remodelling	remodelling	NN
cord-262445-54ng7m92	172	21	processes	process	NNS
cord-262445-54ng7m92	172	22	.	.	.
cord-262445-54ng7m92	173	1	Therefore	therefore	RB
cord-262445-54ng7m92	173	2	,	,	,
cord-262445-54ng7m92	173	3	to	to	TO
cord-262445-54ng7m92	173	4	better	better	RB
cord-262445-54ng7m92	173	5	understand	understand	VB
cord-262445-54ng7m92	173	6	the	the	DT
cord-262445-54ng7m92	173	7	impaired	impaired	JJ
cord-262445-54ng7m92	173	8	development	development	NN
cord-262445-54ng7m92	173	9	of	of	IN
cord-262445-54ng7m92	173	10	the	the	DT
cord-262445-54ng7m92	173	11	muscle	muscle	NN
cord-262445-54ng7m92	173	12	and	and	CC
cord-262445-54ng7m92	173	13	the	the	DT
cord-262445-54ng7m92	173	14	underlying	underlie	VBG
cord-262445-54ng7m92	173	15	mechanisms	mechanism	NNS
cord-262445-54ng7m92	173	16	responsible	responsible	JJ
cord-262445-54ng7m92	173	17	for	for	IN
cord-262445-54ng7m92	173	18	the	the	DT
cord-262445-54ng7m92	173	19	alterations	alteration	NNS
cord-262445-54ng7m92	173	20	reported	report	VBN
cord-262445-54ng7m92	173	21	in	in	IN
cord-262445-54ng7m92	173	22	CP	CP	NNP
cord-262445-54ng7m92	173	23	children	child	NNS
cord-262445-54ng7m92	173	24	,	,	,
cord-262445-54ng7m92	173	25	we	-PRON-	PRP
cord-262445-54ng7m92	173	26	aim	aim	VBP
cord-262445-54ng7m92	173	27	to	to	TO
cord-262445-54ng7m92	173	28	comprehensively	comprehensively	RB
cord-262445-54ng7m92	173	29	describe	describe	VB
cord-262445-54ng7m92	173	30	the	the	DT
cord-262445-54ng7m92	173	31	features	feature	NNS
cord-262445-54ng7m92	173	32	of	of	IN
cord-262445-54ng7m92	173	33	the	the	DT
cord-262445-54ng7m92	173	34	stem	stem	NN
cord-262445-54ng7m92	173	35	cells	cell	NNS
cord-262445-54ng7m92	173	36	from	from	IN
cord-262445-54ng7m92	173	37	CP	cp	NN
cord-262445-54ng7m92	173	38	children	child	NNS
cord-262445-54ng7m92	173	39	compared	compare	VBN
cord-262445-54ng7m92	173	40	to	to	IN
cord-262445-54ng7m92	173	41	stem	stem	NN
cord-262445-54ng7m92	173	42	cells	cell	NNS
cord-262445-54ng7m92	173	43	from	from	IN
cord-262445-54ng7m92	173	44	Typically	typically	RB
cord-262445-54ng7m92	173	45	Developing	develop	VBG
cord-262445-54ng7m92	173	46	children	child	NNS
cord-262445-54ng7m92	173	47	(	(	-LRB-
cord-262445-54ng7m92	173	48	TD	TD	NNP
cord-262445-54ng7m92	173	49	)	)	-RRB-
cord-262445-54ng7m92	173	50	.	.	.
cord-262445-54ng7m92	174	1	As	as	IN
cord-262445-54ng7m92	174	2	a	a	DT
cord-262445-54ng7m92	174	3	starting	starting	NN
cord-262445-54ng7m92	174	4	point	point	NN
cord-262445-54ng7m92	174	5	for	for	IN
cord-262445-54ng7m92	174	6	an	an	DT
cord-262445-54ng7m92	174	7	extended	extended	JJ
cord-262445-54ng7m92	174	8	research	research	NN
cord-262445-54ng7m92	174	9	project	project	NN
cord-262445-54ng7m92	174	10	on	on	IN
cord-262445-54ng7m92	174	11	the	the	DT
cord-262445-54ng7m92	174	12	macroscopic	macroscopic	JJ
cord-262445-54ng7m92	174	13	and	and	CC
cord-262445-54ng7m92	174	14	microscopic	microscopic	JJ
cord-262445-54ng7m92	174	15	muscle	muscle	NN
cord-262445-54ng7m92	174	16	properties	property	NNS
cord-262445-54ng7m92	174	17	of	of	IN
cord-262445-54ng7m92	174	18	these	these	DT
cord-262445-54ng7m92	174	19	children	child	NNS
cord-262445-54ng7m92	174	20	,	,	,
cord-262445-54ng7m92	174	21	the	the	DT
cord-262445-54ng7m92	174	22	current	current	JJ
cord-262445-54ng7m92	174	23	study	study	NN
cord-262445-54ng7m92	174	24	reports	report	VBZ
cord-262445-54ng7m92	174	25	the	the	DT
cord-262445-54ng7m92	174	26	pilot	pilot	NN
cord-262445-54ng7m92	174	27	results	result	VBZ
cord-262445-54ng7m92	174	28	on	on	IN
cord-262445-54ng7m92	174	29	the	the	DT
cord-262445-54ng7m92	174	30	microscopic	microscopic	JJ
cord-262445-54ng7m92	174	31	level	level	NN
cord-262445-54ng7m92	174	32	.	.	.
cord-262445-54ng7m92	175	1	A	a	DT
cord-262445-54ng7m92	175	2	minimally	minimally	RB
cord-262445-54ng7m92	175	3	invasive	invasive	JJ
cord-262445-54ng7m92	175	4	needle	needle	NN
cord-262445-54ng7m92	175	5	microbiopsy	microbiopsy	NN
cord-262445-54ng7m92	175	6	(	(	-LRB-
cord-262445-54ng7m92	175	7	16	16	CD
cord-262445-54ng7m92	175	8	G	G	NNP
cord-262445-54ng7m92	175	9	)	)	-RRB-
cord-262445-54ng7m92	175	10	was	be	VBD
cord-262445-54ng7m92	175	11	applied	apply	VBN
cord-262445-54ng7m92	175	12	to	to	TO
cord-262445-54ng7m92	175	13	obtain	obtain	VB
cord-262445-54ng7m92	175	14	muscle	muscle	NN
cord-262445-54ng7m92	175	15	biopsies	biopsy	NNS
cord-262445-54ng7m92	175	16	from	from	IN
cord-262445-54ng7m92	175	17	the	the	DT
cord-262445-54ng7m92	175	18	Medial	Medial	NNP
cord-262445-54ng7m92	175	19	Gastrocnemius	Gastrocnemius	NNP
cord-262445-54ng7m92	175	20	,	,	,
cord-262445-54ng7m92	175	21	during	during	IN
cord-262445-54ng7m92	175	22	interventions	intervention	NNS
cord-262445-54ng7m92	175	23	that	that	WDT
cord-262445-54ng7m92	175	24	required	require	VBD
cord-262445-54ng7m92	175	25	general	general	JJ
cord-262445-54ng7m92	175	26	anaesthesia	anaesthesia	NN
cord-262445-54ng7m92	175	27	.	.	.
cord-262445-54ng7m92	176	1	A	a	DT
cord-262445-54ng7m92	176	2	total	total	NN
cord-262445-54ng7m92	176	3	of	of	IN
cord-262445-54ng7m92	176	4	10	10	CD
cord-262445-54ng7m92	176	5	CP	cp	NN
cord-262445-54ng7m92	176	6	patients	patient	NNS
cord-262445-54ng7m92	176	7	with	with	IN
cord-262445-54ng7m92	176	8	Gross	Gross	NNP
cord-262445-54ng7m92	176	9	Motor	Motor	NNP
cord-262445-54ng7m92	176	10	Function	Function	NNP
cord-262445-54ng7m92	176	11	Classification	Classification	NNP
cord-262445-54ng7m92	176	12	System	System	NNP
cord-262445-54ng7m92	176	13	level	level	NN
cord-262445-54ng7m92	176	14	I	I	NNP
cord-262445-54ng7m92	176	15	-	-	HYPH
cord-262445-54ng7m92	176	16	III	III	NNP
cord-262445-54ng7m92	176	17	were	be	VBD
cord-262445-54ng7m92	176	18	included	include	VBN
cord-262445-54ng7m92	176	19	within	within	IN
cord-262445-54ng7m92	176	20	a	a	DT
cord-262445-54ng7m92	176	21	range	range	NN
cord-262445-54ng7m92	176	22	from	from	IN
cord-262445-54ng7m92	176	23	2	2	CD
cord-262445-54ng7m92	176	24	to	to	TO
cord-262445-54ng7m92	176	25	9	9	CD
cord-262445-54ng7m92	176	26	years	year	NNS
cord-262445-54ng7m92	176	27	old	old	JJ
cord-262445-54ng7m92	176	28	.	.	.
cord-262445-54ng7m92	177	1	Biopsies	biopsy	NNS
cord-262445-54ng7m92	177	2	on	on	IN
cord-262445-54ng7m92	177	3	TD	TD	NNP
cord-262445-54ng7m92	177	4	children	child	NNS
cord-262445-54ng7m92	177	5	are	be	VBP
cord-262445-54ng7m92	177	6	currently	currently	RB
cord-262445-54ng7m92	177	7	ongoing	ongoing	JJ
cord-262445-54ng7m92	177	8	.	.	.
cord-262445-54ng7m92	178	1	The	the	DT
cord-262445-54ng7m92	178	2	microbiopsy	microbiopsy	JJ
cord-262445-54ng7m92	178	3	technique	technique	NN
cord-262445-54ng7m92	178	4	was	be	VBD
cord-262445-54ng7m92	178	5	well	well	RB
cord-262445-54ng7m92	178	6	-	-	HYPH
cord-262445-54ng7m92	178	7	tolerated	tolerate	VBN
cord-262445-54ng7m92	178	8	.	.	.
cord-262445-54ng7m92	179	1	The	the	DT
cord-262445-54ng7m92	179	2	explant	explant	NN
cord-262445-54ng7m92	179	3	technique	technique	NN
cord-262445-54ng7m92	179	4	resulted	result	VBD
cord-262445-54ng7m92	179	5	in	in	IN
cord-262445-54ng7m92	179	6	a	a	DT
cord-262445-54ng7m92	179	7	reasonable	reasonable	JJ
cord-262445-54ng7m92	179	8	number	number	NN
cord-262445-54ng7m92	179	9	of	of	IN
cord-262445-54ng7m92	179	10	cells	cell	NNS
cord-262445-54ng7m92	179	11	for	for	IN
cord-262445-54ng7m92	179	12	all	all	PDT
cord-262445-54ng7m92	179	13	the	the	DT
cord-262445-54ng7m92	179	14	planned	plan	VBN
cord-262445-54ng7m92	179	15	in	in	IN
cord-262445-54ng7m92	179	16	vitro	vitro	FW
cord-262445-54ng7m92	179	17	examinations	examination	NNS
cord-262445-54ng7m92	179	18	.	.	.
cord-262445-54ng7m92	180	1	Satellite	satellite	NN
cord-262445-54ng7m92	180	2	cells	cell	NNS
cord-262445-54ng7m92	180	3	(	(	-LRB-
cord-262445-54ng7m92	180	4	SCs	SCs	NNP
cord-262445-54ng7m92	180	5	)	)	-RRB-
cord-262445-54ng7m92	180	6	,	,	,
cord-262445-54ng7m92	180	7	mesoangioblasts	mesoangioblast	NNS
cord-262445-54ng7m92	180	8	and	and	CC
cord-262445-54ng7m92	180	9	fibro	fibro	NN
cord-262445-54ng7m92	180	10	-	-	HYPH
cord-262445-54ng7m92	180	11	adipogenic	adipogenic	JJ
cord-262445-54ng7m92	180	12	progenitor	progenitor	NN
cord-262445-54ng7m92	180	13	-	-	HYPH
cord-262445-54ng7m92	180	14	like	like	JJ
cord-262445-54ng7m92	180	15	cells	cell	NNS
cord-262445-54ng7m92	180	16	were	be	VBD
cord-262445-54ng7m92	180	17	isolated	isolate	VBN
cord-262445-54ng7m92	180	18	using	use	VBG
cord-262445-54ng7m92	180	19	Fluorescence	fluorescence	NN
cord-262445-54ng7m92	180	20	-	-	HYPH
cord-262445-54ng7m92	180	21	activated	activate	VBN
cord-262445-54ng7m92	180	22	cell	cell	NN
cord-262445-54ng7m92	180	23	sorting	sorting	NN
cord-262445-54ng7m92	180	24	based	base	VBN
cord-262445-54ng7m92	180	25	on	on	IN
cord-262445-54ng7m92	180	26	respectively	respectively	RB
cord-262445-54ng7m92	180	27	CD56	CD56	NNP
cord-262445-54ng7m92	180	28	,	,	,
cord-262445-54ng7m92	180	29	Alkaline	Alkaline	NNP
cord-262445-54ng7m92	180	30	Phosphatase	Phosphatase	NNP
cord-262445-54ng7m92	180	31	and	and	CC
cord-262445-54ng7m92	180	32	PDGFRa	pdgfra	NN
cord-262445-54ng7m92	180	33	protein	protein	NN
cord-262445-54ng7m92	180	34	expression	expression	NN
cord-262445-54ng7m92	180	35	.	.	.
cord-262445-54ng7m92	181	1	All	all	DT
cord-262445-54ng7m92	181	2	cell	cell	NN
cord-262445-54ng7m92	181	3	types	type	NNS
cord-262445-54ng7m92	181	4	were	be	VBD
cord-262445-54ng7m92	181	5	characterised	characterise	VBN
cord-262445-54ng7m92	181	6	by	by	IN
cord-262445-54ng7m92	181	7	their	-PRON-	PRP$
cord-262445-54ng7m92	181	8	myogenic	myogenic	NNS
cord-262445-54ng7m92	181	9	and/or	and/or	CC
cord-262445-54ng7m92	181	10	adipogenic	adipogenic	JJ
cord-262445-54ng7m92	181	11	differentiation	differentiation	NN
cord-262445-54ng7m92	181	12	potential	potential	NN
cord-262445-54ng7m92	181	13	.	.	.
cord-262445-54ng7m92	182	1	Six	six	CD
cord-262445-54ng7m92	182	2	-	-	HYPH
cord-262445-54ng7m92	182	3	day	day	NN
cord-262445-54ng7m92	182	4	differentiation	differentiation	NN
cord-262445-54ng7m92	182	5	of	of	IN
cord-262445-54ng7m92	182	6	SCs	sc	NNS
cord-262445-54ng7m92	182	7	led	lead	VBD
cord-262445-54ng7m92	182	8	to	to	IN
cord-262445-54ng7m92	182	9	heterogeneous	heterogeneous	JJ
cord-262445-54ng7m92	182	10	levels	level	NNS
cord-262445-54ng7m92	182	11	of	of	IN
cord-262445-54ng7m92	182	12	differentiation	differentiation	NN
cord-262445-54ng7m92	182	13	and	and	CC
cord-262445-54ng7m92	182	14	maturation	maturation	NN
cord-262445-54ng7m92	182	15	based	base	VBN
cord-262445-54ng7m92	182	16	on	on	IN
cord-262445-54ng7m92	182	17	the	the	DT
cord-262445-54ng7m92	182	18	expression	expression	NN
cord-262445-54ng7m92	182	19	of	of	IN
cord-262445-54ng7m92	182	20	Myosin	Myosin	NNP
cord-262445-54ng7m92	182	21	Heavy	Heavy	NNP
cord-262445-54ng7m92	182	22	Chain	Chain	NNP
cord-262445-54ng7m92	182	23	protein	protein	NN
cord-262445-54ng7m92	182	24	and	and	CC
cord-262445-54ng7m92	182	25	on	on	IN
cord-262445-54ng7m92	182	26	fusion	fusion	NN
cord-262445-54ng7m92	182	27	indexes	index	NNS
cord-262445-54ng7m92	182	28	.	.	.
cord-262445-54ng7m92	183	1	In	in	IN
cord-262445-54ng7m92	183	2	addition	addition	NN
cord-262445-54ng7m92	183	3	,	,	,
cord-262445-54ng7m92	183	4	on	on	IN
cord-262445-54ng7m92	183	5	these	these	DT
cord-262445-54ng7m92	183	6	myotubes	myotube	NNS
cord-262445-54ng7m92	183	7	,	,	,
cord-262445-54ng7m92	183	8	disturbed	disturbed	JJ
cord-262445-54ng7m92	183	9	nuclear	nuclear	JJ
cord-262445-54ng7m92	183	10	migration	migration	NN
cord-262445-54ng7m92	183	11	was	be	VBD
cord-262445-54ng7m92	183	12	observed	observe	VBN
cord-262445-54ng7m92	183	13	.	.	.
cord-262445-54ng7m92	184	1	In	in	IN
cord-262445-54ng7m92	184	2	conclusion	conclusion	NN
cord-262445-54ng7m92	184	3	,	,	,
cord-262445-54ng7m92	184	4	microbiopsy	microbiopsy	NNP
cord-262445-54ng7m92	184	5	proved	prove	VBD
cord-262445-54ng7m92	184	6	to	to	TO
cord-262445-54ng7m92	184	7	be	be	VB
cord-262445-54ng7m92	184	8	harmless	harmless	JJ
cord-262445-54ng7m92	184	9	and	and	CC
cord-262445-54ng7m92	184	10	efficient	efficient	JJ
cord-262445-54ng7m92	184	11	for	for	IN
cord-262445-54ng7m92	184	12	our	-PRON-	PRP$
cord-262445-54ng7m92	184	13	purposes	purpose	NNS
cord-262445-54ng7m92	184	14	.	.	.
cord-262445-54ng7m92	185	1	In	in	IN
cord-262445-54ng7m92	185	2	ongoing	ongoing	JJ
cord-262445-54ng7m92	185	3	research	research	NN
cord-262445-54ng7m92	185	4	,	,	,
cord-262445-54ng7m92	185	5	a	a	DT
cord-262445-54ng7m92	185	6	higher	high	JJR
cord-262445-54ng7m92	185	7	number	number	NN
cord-262445-54ng7m92	185	8	of	of	IN
cord-262445-54ng7m92	185	9	patients	patient	NNS
cord-262445-54ng7m92	185	10	and	and	CC
cord-262445-54ng7m92	185	11	multiple	multiple	JJ
cord-262445-54ng7m92	185	12	age	age	NN
cord-262445-54ng7m92	185	13	-	-	HYPH
cord-262445-54ng7m92	185	14	matched	match	VBN
cord-262445-54ng7m92	185	15	TD	TD	NNP
cord-262445-54ng7m92	185	16	children	child	NNS
cord-262445-54ng7m92	185	17	are	be	VBP
cord-262445-54ng7m92	185	18	being	be	VBG
cord-262445-54ng7m92	185	19	included	include	VBN
cord-262445-54ng7m92	185	20	to	to	TO
cord-262445-54ng7m92	185	21	confirm	confirm	VB
cord-262445-54ng7m92	185	22	our	-PRON-	PRP$
cord-262445-54ng7m92	185	23	preliminary	preliminary	JJ
cord-262445-54ng7m92	185	24	observations	observation	NNS
cord-262445-54ng7m92	185	25	.	.	.
cord-262445-54ng7m92	186	1	Future	future	JJ
cord-262445-54ng7m92	186	2	analysis	analysis	NN
cord-262445-54ng7m92	186	3	will	will	MD
cord-262445-54ng7m92	186	4	focus	focus	VB
cord-262445-54ng7m92	186	5	on	on	IN
cord-262445-54ng7m92	186	6	nuclear	nuclear	JJ
cord-262445-54ng7m92	186	7	migration	migration	NN
cord-262445-54ng7m92	186	8	and	and	CC
cord-262445-54ng7m92	186	9	other	other	JJ
cord-262445-54ng7m92	186	10	impaired	impair	VBN
cord-262445-54ng7m92	186	11	features	feature	NNS
cord-262445-54ng7m92	186	12	that	that	WDT
cord-262445-54ng7m92	186	13	will	will	MD
cord-262445-54ng7m92	186	14	be	be	VB
cord-262445-54ng7m92	186	15	further	further	RB
cord-262445-54ng7m92	186	16	assessed	assess	VBN
cord-262445-54ng7m92	186	17	in	in	IN
cord-262445-54ng7m92	186	18	the	the	DT
cord-262445-54ng7m92	186	19	upcoming	upcoming	JJ
cord-262445-54ng7m92	186	20	months	month	NNS
cord-262445-54ng7m92	186	21	.	.	.
cord-262445-54ng7m92	187	1	Mitochondrial	mitochondrial	JJ
cord-262445-54ng7m92	187	2	calcium	calcium	NN
cord-262445-54ng7m92	187	3	uptake	uptake	NN
cord-262445-54ng7m92	187	4	plays	play	VBZ
cord-262445-54ng7m92	187	5	a	a	DT
cord-262445-54ng7m92	187	6	key	key	JJ
cord-262445-54ng7m92	187	7	role	role	NN
cord-262445-54ng7m92	187	8	in	in	IN
cord-262445-54ng7m92	187	9	modulating	modulate	VBG
cord-262445-54ng7m92	187	10	cell	cell	NN
cord-262445-54ng7m92	187	11	metabolism	metabolism	NN
cord-262445-54ng7m92	187	12	,	,	,
cord-262445-54ng7m92	187	13	cell	cell	NN
cord-262445-54ng7m92	187	14	survival	survival	NN
cord-262445-54ng7m92	187	15	and	and	CC
cord-262445-54ng7m92	187	16	other	other	JJ
cord-262445-54ng7m92	187	17	crucial	crucial	JJ
cord-262445-54ng7m92	187	18	cell	cell	NN
cord-262445-54ng7m92	187	19	functions	function	NNS
cord-262445-54ng7m92	187	20	.	.	.
cord-262445-54ng7m92	188	1	Calcium	calcium	NN
cord-262445-54ng7m92	188	2	accumulates	accumulate	VBZ
cord-262445-54ng7m92	188	3	into	into	IN
cord-262445-54ng7m92	188	4	the	the	DT
cord-262445-54ng7m92	188	5	mitochondrial	mitochondrial	JJ
cord-262445-54ng7m92	188	6	matrix	matrix	NN
cord-262445-54ng7m92	188	7	through	through	IN
cord-262445-54ng7m92	188	8	the	the	DT
cord-262445-54ng7m92	188	9	mitochondrial	mitochondrial	JJ
cord-262445-54ng7m92	188	10	calcium	calcium	NN
cord-262445-54ng7m92	188	11	uniporter	uniporter	NN
cord-262445-54ng7m92	188	12	(	(	-LRB-
cord-262445-54ng7m92	188	13	MCU	MCU	NNP
cord-262445-54ng7m92	188	14	)	)	-RRB-
cord-262445-54ng7m92	188	15	.	.	.
cord-262445-54ng7m92	189	1	Few	few	JJ
cord-262445-54ng7m92	189	2	years	year	NNS
cord-262445-54ng7m92	189	3	ago	ago	RB
cord-262445-54ng7m92	189	4	a	a	DT
cord-262445-54ng7m92	189	5	MCU	MCU	NNP
cord-262445-54ng7m92	189	6	homolog	homolog	NN
cord-262445-54ng7m92	189	7	has	have	VBZ
cord-262445-54ng7m92	189	8	been	be	VBN
cord-262445-54ng7m92	189	9	discovered	discover	VBN
cord-262445-54ng7m92	189	10	,	,	,
cord-262445-54ng7m92	189	11	that	that	WDT
cord-262445-54ng7m92	189	12	was	be	VBD
cord-262445-54ng7m92	189	13	called	call	VBN
cord-262445-54ng7m92	189	14	MCUb	MCUb	NNS
cord-262445-54ng7m92	189	15	.	.	.
cord-262445-54ng7m92	190	1	MCU	MCU	NNP
cord-262445-54ng7m92	190	2	and	and	CC
cord-262445-54ng7m92	190	3	MCUb	MCUb	NNP
cord-262445-54ng7m92	190	4	share	share	VBP
cord-262445-54ng7m92	190	5	a	a	DT
cord-262445-54ng7m92	190	6	50	50	CD
cord-262445-54ng7m92	190	7	%	%	NN
cord-262445-54ng7m92	190	8	sequence	sequence	NN
cord-262445-54ng7m92	190	9	and	and	CC
cord-262445-54ng7m92	190	10	structure	structure	NN
cord-262445-54ng7m92	190	11	similarity	similarity	NN
cord-262445-54ng7m92	190	12	although	although	IN
cord-262445-54ng7m92	190	13	some	some	DT
cord-262445-54ng7m92	190	14	conserved	conserved	JJ
cord-262445-54ng7m92	190	15	differences	difference	NNS
cord-262445-54ng7m92	190	16	in	in	IN
cord-262445-54ng7m92	190	17	the	the	DT
cord-262445-54ng7m92	190	18	primary	primary	JJ
cord-262445-54ng7m92	190	19	sequence	sequence	NN
cord-262445-54ng7m92	190	20	prevent	prevent	VBP
cord-262445-54ng7m92	190	21	MCUb	MCUb	NNS
cord-262445-54ng7m92	190	22	from	from	IN
cord-262445-54ng7m92	190	23	forming	form	VBG
cord-262445-54ng7m92	190	24	a	a	DT
cord-262445-54ng7m92	190	25	Ca	Ca	NNP
cord-262445-54ng7m92	190	26	2	2	CD
cord-262445-54ng7m92	190	27	+	+	CC
cord-262445-54ng7m92	190	28	-permeable	-permeable	JJ
cord-262445-54ng7m92	190	29	channel	channel	NN
cord-262445-54ng7m92	190	30	,	,	,
cord-262445-54ng7m92	190	31	thus	thus	RB
cord-262445-54ng7m92	190	32	acting	act	VBG
cord-262445-54ng7m92	190	33	as	as	IN
cord-262445-54ng7m92	190	34	a	a	DT
cord-262445-54ng7m92	190	35	dominant	dominant	JJ
cord-262445-54ng7m92	190	36	-	-	HYPH
cord-262445-54ng7m92	190	37	negative	negative	JJ
cord-262445-54ng7m92	190	38	subunit	subunit	NN
cord-262445-54ng7m92	190	39	.	.	.
cord-262445-54ng7m92	191	1	Interestingly	interestingly	RB
cord-262445-54ng7m92	191	2	,	,	,
cord-262445-54ng7m92	191	3	MCUb	MCUb	NNP
cord-262445-54ng7m92	191	4	/	/	SYM
cord-262445-54ng7m92	191	5	MCU	MCU	NNP
cord-262445-54ng7m92	191	6	expression	expression	NN
cord-262445-54ng7m92	191	7	ratio	ratio	NN
cord-262445-54ng7m92	191	8	varies	vary	VBZ
cord-262445-54ng7m92	191	9	greatly	greatly	RB
cord-262445-54ng7m92	191	10	among	among	IN
cord-262445-54ng7m92	191	11	tissues	tissue	NNS
cord-262445-54ng7m92	191	12	,	,	,
cord-262445-54ng7m92	191	13	suggesting	suggest	VBG
cord-262445-54ng7m92	191	14	that	that	IN
cord-262445-54ng7m92	191	15	it	-PRON-	PRP
cord-262445-54ng7m92	191	16	might	may	MD
cord-262445-54ng7m92	191	17	contribute	contribute	VB
cord-262445-54ng7m92	191	18	to	to	IN
cord-262445-54ng7m92	191	19	the	the	DT
cord-262445-54ng7m92	191	20	spatiotemporal	spatiotemporal	JJ
cord-262445-54ng7m92	191	21	control	control	NN
cord-262445-54ng7m92	191	22	of	of	IN
cord-262445-54ng7m92	191	23	mitochondrial	mitochondrial	JJ
cord-262445-54ng7m92	191	24	calcium	calcium	NN
cord-262445-54ng7m92	191	25	uptake	uptake	NN
cord-262445-54ng7m92	191	26	.	.	.
cord-262445-54ng7m92	192	1	Here	here	RB
cord-262445-54ng7m92	192	2	we	-PRON-	PRP
cord-262445-54ng7m92	192	3	show	show	VBP
cord-262445-54ng7m92	192	4	that	that	IN
cord-262445-54ng7m92	192	5	MCUb	mcub	NN
cord-262445-54ng7m92	192	6	is	be	VBZ
cord-262445-54ng7m92	192	7	highly	highly	RB
cord-262445-54ng7m92	192	8	expressed	express	VBN
cord-262445-54ng7m92	192	9	during	during	IN
cord-262445-54ng7m92	192	10	skeletal	skeletal	JJ
cord-262445-54ng7m92	192	11	muscle	muscle	NN
cord-262445-54ng7m92	192	12	regeneration	regeneration	NN
cord-262445-54ng7m92	192	13	,	,	,
cord-262445-54ng7m92	192	14	a	a	DT
cord-262445-54ng7m92	192	15	process	process	NN
cord-262445-54ng7m92	192	16	that	that	WDT
cord-262445-54ng7m92	192	17	is	be	VBZ
cord-262445-54ng7m92	192	18	mainly	mainly	RB
cord-262445-54ng7m92	192	19	regulated	regulate	VBN
cord-262445-54ng7m92	192	20	by	by	IN
cord-262445-54ng7m92	192	21	phenotypic	phenotypic	JJ
cord-262445-54ng7m92	192	22	skewing	skewing	NN
cord-262445-54ng7m92	192	23	of	of	IN
cord-262445-54ng7m92	192	24	tissue	tissue	NN
cord-262445-54ng7m92	192	25	resident	resident	NN
cord-262445-54ng7m92	192	26	and	and	CC
cord-262445-54ng7m92	192	27	freshly	freshly	RB
cord-262445-54ng7m92	192	28	recruited	recruit	VBN
cord-262445-54ng7m92	192	29	macrophages	macrophage	NNS
cord-262445-54ng7m92	192	30	.	.	.
cord-262445-54ng7m92	193	1	We	-PRON-	PRP
cord-262445-54ng7m92	193	2	have	have	VBP
cord-262445-54ng7m92	193	3	demonstrated	demonstrate	VBN
cord-262445-54ng7m92	193	4	that	that	IN
cord-262445-54ng7m92	193	5	MCUb	mcub	JJ
cord-262445-54ng7m92	193	6	expression	expression	NN
cord-262445-54ng7m92	193	7	is	be	VBZ
cord-262445-54ng7m92	193	8	specifically	specifically	RB
cord-262445-54ng7m92	193	9	induced	induce	VBN
cord-262445-54ng7m92	193	10	in	in	IN
cord-262445-54ng7m92	193	11	macrophages	macrophage	NNS
cord-262445-54ng7m92	193	12	,	,	,
cord-262445-54ng7m92	193	13	the	the	DT
cord-262445-54ng7m92	193	14	most	most	RBS
cord-262445-54ng7m92	193	15	abundant	abundant	JJ
cord-262445-54ng7m92	193	16	cell	cell	NN
cord-262445-54ng7m92	193	17	population	population	NN
cord-262445-54ng7m92	193	18	in	in	IN
cord-262445-54ng7m92	193	19	a	a	DT
cord-262445-54ng7m92	193	20	regenerating	regenerate	VBG
cord-262445-54ng7m92	193	21	muscle	muscle	NN
cord-262445-54ng7m92	193	22	that	that	WDT
cord-262445-54ng7m92	193	23	drive	drive	VBP
cord-262445-54ng7m92	193	24	both	both	CC
cord-262445-54ng7m92	193	25	the	the	DT
cord-262445-54ng7m92	193	26	proliferation	proliferation	NN
cord-262445-54ng7m92	193	27	and	and	CC
cord-262445-54ng7m92	193	28	differentiation	differentiation	NN
cord-262445-54ng7m92	193	29	of	of	IN
cord-262445-54ng7m92	193	30	the	the	DT
cord-262445-54ng7m92	193	31	muscle	muscle	NN
cord-262445-54ng7m92	193	32	stem	stem	NN
cord-262445-54ng7m92	193	33	cells	cell	NNS
cord-262445-54ng7m92	193	34	,	,	,
cord-262445-54ng7m92	193	35	satellite	satellite	NN
cord-262445-54ng7m92	193	36	cells	cell	NNS
cord-262445-54ng7m92	193	37	,	,	,
cord-262445-54ng7m92	193	38	thus	thus	RB
cord-262445-54ng7m92	193	39	affecting	affect	VBG
cord-262445-54ng7m92	193	40	the	the	DT
cord-262445-54ng7m92	193	41	progression	progression	NN
cord-262445-54ng7m92	193	42	of	of	IN
cord-262445-54ng7m92	193	43	healing	healing	NN
cord-262445-54ng7m92	193	44	after	after	IN
cord-262445-54ng7m92	193	45	muscle	muscle	NN
cord-262445-54ng7m92	193	46	damage	damage	NN
cord-262445-54ng7m92	193	47	.	.	.
cord-262445-54ng7m92	194	1	In	in	IN
cord-262445-54ng7m92	194	2	vitro	vitro	FW
cord-262445-54ng7m92	194	3	and	and	CC
cord-262445-54ng7m92	194	4	in	in	IN
cord-262445-54ng7m92	194	5	vivo	vivo	NN
cord-262445-54ng7m92	194	6	experiments	experiment	NNS
cord-262445-54ng7m92	194	7	demonstrated	demonstrate	VBD
cord-262445-54ng7m92	194	8	that	that	IN
cord-262445-54ng7m92	194	9	the	the	DT
cord-262445-54ng7m92	194	10	absence	absence	NN
cord-262445-54ng7m92	194	11	of	of	IN
cord-262445-54ng7m92	194	12	MCU	MCU	NNP
cord-262445-54ng7m92	194	13	affects	affect	VBZ
cord-262445-54ng7m92	194	14	macrophages	macrophage	NNS
cord-262445-54ng7m92	194	15	skewing	skew	VBG
cord-262445-54ng7m92	194	16	from	from	IN
cord-262445-54ng7m92	194	17	a	a	DT
cord-262445-54ng7m92	194	18	pro	pro	JJ
cord-262445-54ng7m92	194	19	(	(	-LRB-
cord-262445-54ng7m92	194	20	M1	M1	NNP
cord-262445-54ng7m92	194	21	)	)	-RRB-
cord-262445-54ng7m92	194	22	to	to	IN
cord-262445-54ng7m92	194	23	an	an	DT
cord-262445-54ng7m92	194	24	anti	anti	JJ
cord-262445-54ng7m92	194	25	-	-	JJ
cord-262445-54ng7m92	194	26	inflammatory	inflammatory	JJ
cord-262445-54ng7m92	194	27	profile	profile	NN
cord-262445-54ng7m92	194	28	(	(	-LRB-
cord-262445-54ng7m92	194	29	M2	M2	NNP
cord-262445-54ng7m92	194	30	)	)	-RRB-
cord-262445-54ng7m92	194	31	.	.	.
cord-262445-54ng7m92	195	1	Indeed	indeed	RB
cord-262445-54ng7m92	195	2	,	,	,
cord-262445-54ng7m92	195	3	macrophages	macrophage	NNS
cord-262445-54ng7m92	195	4	of	of	IN
cord-262445-54ng7m92	195	5	mice	mouse	NNS
cord-262445-54ng7m92	195	6	lacking	lack	VBG
cord-262445-54ng7m92	195	7	MCUb	MCUb	NNS
cord-262445-54ng7m92	195	8	are	be	VBP
cord-262445-54ng7m92	195	9	more	more	RBR
cord-262445-54ng7m92	195	10	prone	prone	JJ
cord-262445-54ng7m92	195	11	to	to	TO
cord-262445-54ng7m92	195	12	acquire	acquire	VB
cord-262445-54ng7m92	195	13	a	a	DT
cord-262445-54ng7m92	195	14	pro	pro	JJ
cord-262445-54ng7m92	195	15	-	-	JJ
cord-262445-54ng7m92	195	16	inflammatory	inflammatory	JJ
cord-262445-54ng7m92	195	17	M1	M1	NNP
cord-262445-54ng7m92	195	18	profile	profile	NN
cord-262445-54ng7m92	195	19	.	.	.
cord-262445-54ng7m92	196	1	Since	since	IN
cord-262445-54ng7m92	196	2	M2	m2	JJ
cord-262445-54ng7m92	196	3	macrophages	macrophage	NNS
cord-262445-54ng7m92	196	4	have	have	VBP
cord-262445-54ng7m92	196	5	a	a	DT
cord-262445-54ng7m92	196	6	proregenerative	proregenerative	JJ
cord-262445-54ng7m92	196	7	role	role	NN
cord-262445-54ng7m92	196	8	and	and	CC
cord-262445-54ng7m92	196	9	promote	promote	VB
cord-262445-54ng7m92	196	10	myogenic	myogenic	JJ
cord-262445-54ng7m92	196	11	precursor	precursor	NN
cord-262445-54ng7m92	196	12	cell	cell	NN
cord-262445-54ng7m92	196	13	differentiation	differentiation	NN
cord-262445-54ng7m92	196	14	,	,	,
cord-262445-54ng7m92	196	15	we	-PRON-	PRP
cord-262445-54ng7m92	196	16	hypothesized	hypothesize	VBD
cord-262445-54ng7m92	196	17	that	that	IN
cord-262445-54ng7m92	196	18	MCUb	mcub	JJ
cord-262445-54ng7m92	196	19	absence	absence	NN
cord-262445-54ng7m92	196	20	,	,	,
cord-262445-54ng7m92	196	21	by	by	IN
cord-262445-54ng7m92	196	22	affecting	affect	VBG
cord-262445-54ng7m92	196	23	M2	m2	JJ
cord-262445-54ng7m92	196	24	polarization	polarization	NN
cord-262445-54ng7m92	196	25	,	,	,
cord-262445-54ng7m92	196	26	might	may	MD
cord-262445-54ng7m92	196	27	influence	influence	VB
cord-262445-54ng7m92	196	28	the	the	DT
cord-262445-54ng7m92	196	29	correct	correct	JJ
cord-262445-54ng7m92	196	30	remodeling	remodeling	NN
cord-262445-54ng7m92	196	31	and	and	CC
cord-262445-54ng7m92	196	32	reorganization	reorganization	NN
cord-262445-54ng7m92	196	33	of	of	IN
cord-262445-54ng7m92	196	34	skeletal	skeletal	JJ
cord-262445-54ng7m92	196	35	muscle	muscle	NN
cord-262445-54ng7m92	196	36	structure	structure	NN
cord-262445-54ng7m92	196	37	after	after	IN
cord-262445-54ng7m92	196	38	damage	damage	NN
cord-262445-54ng7m92	196	39	.	.	.
cord-262445-54ng7m92	197	1	Our	-PRON-	PRP$
cord-262445-54ng7m92	197	2	results	result	NNS
cord-262445-54ng7m92	197	3	clearly	clearly	RB
cord-262445-54ng7m92	197	4	show	show	VBP
cord-262445-54ng7m92	197	5	that	that	IN
cord-262445-54ng7m92	197	6	regenerating	regenerate	VBG
cord-262445-54ng7m92	197	7	muscles	muscle	NNS
cord-262445-54ng7m92	197	8	lacking	lack	VBG
cord-262445-54ng7m92	197	9	MCUb	MCUb	NNS
cord-262445-54ng7m92	197	10	show	show	VBP
cord-262445-54ng7m92	197	11	a	a	DT
cord-262445-54ng7m92	197	12	decrease	decrease	NN
cord-262445-54ng7m92	197	13	in	in	IN
cord-262445-54ng7m92	197	14	the	the	DT
cord-262445-54ng7m92	197	15	expression	expression	NN
cord-262445-54ng7m92	197	16	level	level	NN
cord-262445-54ng7m92	197	17	of	of	IN
cord-262445-54ng7m92	197	18	myogenic	myogenic	JJ
cord-262445-54ng7m92	197	19	regulatory	regulatory	JJ
cord-262445-54ng7m92	197	20	transcription	transcription	NN
cord-262445-54ng7m92	197	21	factors	factor	NNS
cord-262445-54ng7m92	197	22	involved	involve	VBN
cord-262445-54ng7m92	197	23	in	in	IN
cord-262445-54ng7m92	197	24	satellite	satellite	NN
cord-262445-54ng7m92	197	25	cells	cell	NNS
cord-262445-54ng7m92	197	26	activation	activation	NN
cord-262445-54ng7m92	197	27	and	and	CC
cord-262445-54ng7m92	197	28	differentiation	differentiation	NN
cord-262445-54ng7m92	197	29	.	.	.
cord-262445-54ng7m92	198	1	We	-PRON-	PRP
cord-262445-54ng7m92	198	2	also	also	RB
cord-262445-54ng7m92	198	3	observed	observe	VBD
cord-262445-54ng7m92	198	4	a	a	DT
cord-262445-54ng7m92	198	5	decrease	decrease	NN
cord-262445-54ng7m92	198	6	in	in	IN
cord-262445-54ng7m92	198	7	the	the	DT
cord-262445-54ng7m92	198	8	percentage	percentage	NN
cord-262445-54ng7m92	198	9	of	of	IN
cord-262445-54ng7m92	198	10	regenerating	regenerate	VBG
cord-262445-54ng7m92	198	11	myofibers	myofiber	NNS
cord-262445-54ng7m92	198	12	and	and	CC
cord-262445-54ng7m92	198	13	a	a	DT
cord-262445-54ng7m92	198	14	decrease	decrease	NN
cord-262445-54ng7m92	198	15	in	in	IN
cord-262445-54ng7m92	198	16	collagen	collagen	NN
cord-262445-54ng7m92	198	17	deposition	deposition	NN
cord-262445-54ng7m92	198	18	.	.	.
cord-262445-54ng7m92	199	1	In	in	IN
cord-262445-54ng7m92	199	2	addition	addition	NN
cord-262445-54ng7m92	199	3	,	,	,
cord-262445-54ng7m92	199	4	co	co	NN
cord-262445-54ng7m92	199	5	-	-	NN
cord-262445-54ng7m92	199	6	culture	culture	JJ
cord-262445-54ng7m92	199	7	experiments	experiment	NNS
cord-262445-54ng7m92	199	8	demonstrated	demonstrate	VBD
cord-262445-54ng7m92	199	9	that	that	IN
cord-262445-54ng7m92	199	10	macrophage	macrophage	NN
cord-262445-54ng7m92	199	11	-	-	HYPH
cord-262445-54ng7m92	199	12	conditioned	condition	VBN
cord-262445-54ng7m92	199	13	medium	medium	NN
cord-262445-54ng7m92	199	14	from	from	IN
cord-262445-54ng7m92	199	15	M2	M2	NNP
cord-262445-54ng7m92	199	16	MCUb	MCUb	NNP
cord-262445-54ng7m92	199	17	KO	KO	NNP
cord-262445-54ng7m92	199	18	macrophages	macrophage	NNS
cord-262445-54ng7m92	199	19	drastically	drastically	RB
cord-262445-54ng7m92	199	20	decreases	decrease	VBZ
cord-262445-54ng7m92	199	21	satellite	satellite	NN
cord-262445-54ng7m92	199	22	cell	cell	NN
cord-262445-54ng7m92	199	23	differentiation	differentiation	NN
cord-262445-54ng7m92	199	24	.	.	.
cord-262445-54ng7m92	200	1	Altogether	altogether	RB
cord-262445-54ng7m92	200	2	these	these	DT
cord-262445-54ng7m92	200	3	results	result	NNS
cord-262445-54ng7m92	200	4	demonstrate	demonstrate	VBP
cord-262445-54ng7m92	200	5	the	the	DT
cord-262445-54ng7m92	200	6	role	role	NN
cord-262445-54ng7m92	200	7	of	of	IN
cord-262445-54ng7m92	200	8	mitochondrial	mitochondrial	NN
cord-262445-54ng7m92	201	1	Ca	ca	NN
cord-262445-54ng7m92	201	2	2	2	CD
cord-262445-54ng7m92	201	3	+	+	CC
cord-262445-54ng7m92	201	4	uptake	uptake	NN
cord-262445-54ng7m92	201	5	in	in	IN
cord-262445-54ng7m92	201	6	promoting	promote	VBG
cord-262445-54ng7m92	201	7	the	the	DT
cord-262445-54ng7m92	201	8	polarization	polarization	NN
cord-262445-54ng7m92	201	9	of	of	IN
cord-262445-54ng7m92	201	10	macrophages	macrophage	NNS
cord-262445-54ng7m92	201	11	towards	towards	IN
cord-262445-54ng7m92	201	12	an	an	DT
cord-262445-54ng7m92	201	13	M2	m2	JJ
cord-262445-54ng7m92	201	14	pro	pro	JJ
cord-262445-54ng7m92	201	15	-	-	JJ
cord-262445-54ng7m92	201	16	regenerative	regenerative	JJ
cord-262445-54ng7m92	201	17	profile	profile	NN
cord-262445-54ng7m92	201	18	during	during	IN
cord-262445-54ng7m92	201	19	skeletal	skeletal	JJ
cord-262445-54ng7m92	201	20	muscle	muscle	NN
cord-262445-54ng7m92	201	21	regeneration	regeneration	NN
cord-262445-54ng7m92	201	22	.	.	.
cord-262445-54ng7m92	202	1	Further	further	JJ
cord-262445-54ng7m92	202	2	experiments	experiment	NNS
cord-262445-54ng7m92	202	3	will	will	MD
cord-262445-54ng7m92	202	4	help	help	VB
cord-262445-54ng7m92	202	5	to	to	TO
cord-262445-54ng7m92	202	6	clarify	clarify	VB
cord-262445-54ng7m92	202	7	the	the	DT
cord-262445-54ng7m92	202	8	role	role	NN
cord-262445-54ng7m92	202	9	of	of	IN
cord-262445-54ng7m92	202	10	mitochondrial	mitochondrial	JJ
cord-262445-54ng7m92	202	11	calcium	calcium	NN
cord-262445-54ng7m92	202	12	during	during	IN
cord-262445-54ng7m92	202	13	skeletal	skeletal	JJ
cord-262445-54ng7m92	202	14	muscle	muscle	NN
cord-262445-54ng7m92	202	15	regeneration	regeneration	NN
cord-262445-54ng7m92	202	16	.	.	.
cord-262445-54ng7m92	203	1	Dystrophic	dystrophic	JJ
cord-262445-54ng7m92	203	2	muscle	muscle	NN
cord-262445-54ng7m92	203	3	is	be	VBZ
cord-262445-54ng7m92	203	4	characterised	characterise	VBN
cord-262445-54ng7m92	203	5	by	by	IN
cord-262445-54ng7m92	203	6	chronic	chronic	JJ
cord-262445-54ng7m92	203	7	injury	injury	NN
cord-262445-54ng7m92	203	8	,	,	,
cord-262445-54ng7m92	203	9	and	and	CC
cord-262445-54ng7m92	203	10	a	a	DT
cord-262445-54ng7m92	203	11	steady	steady	JJ
cord-262445-54ng7m92	203	12	recruitment	recruitment	NN
cord-262445-54ng7m92	203	13	of	of	IN
cord-262445-54ng7m92	203	14	inflammatory	inflammatory	JJ
cord-262445-54ng7m92	203	15	Ly6C	Ly6C	NNP
cord-262445-54ng7m92	203	16	hi	hi	UH
cord-262445-54ng7m92	203	17	monocytes	monocyte	NNS
cord-262445-54ng7m92	203	18	.	.	.
cord-262445-54ng7m92	204	1	Recent	recent	JJ
cord-262445-54ng7m92	204	2	studies	study	NNS
cord-262445-54ng7m92	204	3	have	have	VBP
cord-262445-54ng7m92	204	4	identified	identify	VBN
cord-262445-54ng7m92	204	5	the	the	DT
cord-262445-54ng7m92	204	6	spleen	spleen	NNS
cord-262445-54ng7m92	204	7	as	as	IN
cord-262445-54ng7m92	204	8	the	the	DT
cord-262445-54ng7m92	204	9	dominant	dominant	JJ
cord-262445-54ng7m92	204	10	reservoir	reservoir	NN
cord-262445-54ng7m92	204	11	of	of	IN
cord-262445-54ng7m92	204	12	these	these	DT
cord-262445-54ng7m92	204	13	cells	cell	NNS
cord-262445-54ng7m92	204	14	during	during	IN
cord-262445-54ng7m92	204	15	chronic	chronic	JJ
cord-262445-54ng7m92	204	16	inflammation	inflammation	NN
cord-262445-54ng7m92	204	17	.	.	.
cord-262445-54ng7m92	205	1	Here	here	RB
cord-262445-54ng7m92	205	2	we	-PRON-	PRP
cord-262445-54ng7m92	205	3	investigated	investigate	VBD
cord-262445-54ng7m92	205	4	the	the	DT
cord-262445-54ng7m92	205	5	hitherto	hitherto	RB
cord-262445-54ng7m92	205	6	unexplored	unexplored	JJ
cord-262445-54ng7m92	205	7	contribution	contribution	NN
cord-262445-54ng7m92	205	8	of	of	IN
cord-262445-54ng7m92	205	9	splenic	splenic	JJ
cord-262445-54ng7m92	205	10	Ly6C	Ly6C	NNP
cord-262445-54ng7m92	205	11	hi	hi	UH
cord-262445-54ng7m92	205	12	monocytes	monocyte	NNS
cord-262445-54ng7m92	205	13	to	to	TO
cord-262445-54ng7m92	205	14	dystrophic	dystrophic	VB
cord-262445-54ng7m92	205	15	muscle	muscle	NN
cord-262445-54ng7m92	205	16	pathology	pathology	NN
cord-262445-54ng7m92	205	17	.	.	.
cord-262445-54ng7m92	206	1	Using	use	VBG
cord-262445-54ng7m92	206	2	the	the	DT
cord-262445-54ng7m92	206	3	mdx	mdx	NNP
cord-262445-54ng7m92	206	4	mouse	mouse	NN
cord-262445-54ng7m92	206	5	model	model	NN
cord-262445-54ng7m92	206	6	of	of	IN
cord-262445-54ng7m92	206	7	muscular	muscular	JJ
cord-262445-54ng7m92	206	8	dystrophy	dystrophy	NN
cord-262445-54ng7m92	206	9	,	,	,
cord-262445-54ng7m92	206	10	we	-PRON-	PRP
cord-262445-54ng7m92	206	11	show	show	VBP
cord-262445-54ng7m92	206	12	that	that	IN
cord-262445-54ng7m92	206	13	Ly6C	Ly6C	NNP
cord-262445-54ng7m92	206	14	hi	hi	UH
cord-262445-54ng7m92	206	15	monocytes	monocyte	NNS
cord-262445-54ng7m92	206	16	accumulate	accumulate	VBP
cord-262445-54ng7m92	206	17	in	in	IN
cord-262445-54ng7m92	206	18	great	great	JJ
cord-262445-54ng7m92	206	19	numbers	number	NNS
cord-262445-54ng7m92	206	20	in	in	IN
cord-262445-54ng7m92	206	21	the	the	DT
cord-262445-54ng7m92	206	22	spleen	spleen	NN
cord-262445-54ng7m92	206	23	over	over	IN
cord-262445-54ng7m92	206	24	the	the	DT
cord-262445-54ng7m92	206	25	course	course	NN
cord-262445-54ng7m92	206	26	of	of	IN
cord-262445-54ng7m92	206	27	the	the	DT
cord-262445-54ng7m92	206	28	disease	disease	NN
cord-262445-54ng7m92	206	29	.	.	.
cord-262445-54ng7m92	207	1	The	the	DT
cord-262445-54ng7m92	207	2	chemokine	chemokine	NN
cord-262445-54ng7m92	207	3	receptor	receptor	NN
cord-262445-54ng7m92	207	4	CCR2	CCR2	NNP
cord-262445-54ng7m92	207	5	was	be	VBD
cord-262445-54ng7m92	207	6	upregulated	upregulate	VBN
cord-262445-54ng7m92	207	7	before	before	IN
cord-262445-54ng7m92	207	8	disease	disease	NN
cord-262445-54ng7m92	207	9	onset	onset	NN
cord-262445-54ng7m92	207	10	,	,	,
cord-262445-54ng7m92	207	11	enabling	enable	VBG
cord-262445-54ng7m92	207	12	their	-PRON-	PRP$
cord-262445-54ng7m92	207	13	egress	egress	NN
cord-262445-54ng7m92	207	14	from	from	IN
cord-262445-54ng7m92	207	15	the	the	DT
cord-262445-54ng7m92	207	16	spleen	spleen	NN
cord-262445-54ng7m92	207	17	.	.	.
cord-262445-54ng7m92	208	1	Splenectomy	Splenectomy	NNP
cord-262445-54ng7m92	208	2	performed	perform	VBD
cord-262445-54ng7m92	208	3	before	before	IN
cord-262445-54ng7m92	208	4	disease	disease	NN
cord-262445-54ng7m92	208	5	onset	onset	NN
cord-262445-54ng7m92	208	6	significantly	significantly	RB
cord-262445-54ng7m92	208	7	reduced	reduce	VBD
cord-262445-54ng7m92	208	8	the	the	DT
cord-262445-54ng7m92	208	9	number	number	NN
cord-262445-54ng7m92	208	10	of	of	IN
cord-262445-54ng7m92	208	11	Ly6C	ly6c	JJ
cord-262445-54ng7m92	208	12	hi	hi	UH
cord-262445-54ng7m92	208	13	monocytes	monocyte	NNS
cord-262445-54ng7m92	208	14	infiltrating	infiltrate	VBG
cord-262445-54ng7m92	208	15	dystrophic	dystrophic	JJ
cord-262445-54ng7m92	208	16	limb	limb	NN
cord-262445-54ng7m92	208	17	muscle	muscle	NN
cord-262445-54ng7m92	208	18	.	.	.
cord-262445-54ng7m92	209	1	Moreover	moreover	RB
cord-262445-54ng7m92	209	2	,	,	,
cord-262445-54ng7m92	209	3	in	in	IN
cord-262445-54ng7m92	209	4	the	the	DT
cord-262445-54ng7m92	209	5	absence	absence	NN
cord-262445-54ng7m92	209	6	of	of	IN
cord-262445-54ng7m92	209	7	splenic	splenic	JJ
cord-262445-54ng7m92	209	8	Ly6C	ly6c	JJ
cord-262445-54ng7m92	209	9	hi	hi	UH
cord-262445-54ng7m92	209	10	monocytes	monocyte	NNS
cord-262445-54ng7m92	209	11	there	there	EX
cord-262445-54ng7m92	209	12	was	be	VBD
cord-262445-54ng7m92	209	13	a	a	DT
cord-262445-54ng7m92	209	14	significant	significant	JJ
cord-262445-54ng7m92	209	15	reduction	reduction	NN
cord-262445-54ng7m92	209	16	in	in	IN
cord-262445-54ng7m92	209	17	dystrophic	dystrophic	JJ
cord-262445-54ng7m92	209	18	muscle	muscle	NN
cord-262445-54ng7m92	209	19	inflammation	inflammation	NN
cord-262445-54ng7m92	209	20	and	and	CC
cord-262445-54ng7m92	209	21	necrosis	necrosis	NN
cord-262445-54ng7m92	209	22	,	,	,
cord-262445-54ng7m92	209	23	along	along	IN
cord-262445-54ng7m92	209	24	with	with	IN
cord-262445-54ng7m92	209	25	improved	improve	VBN
cord-262445-54ng7m92	209	26	regeneration	regeneration	NN
cord-262445-54ng7m92	209	27	during	during	IN
cord-262445-54ng7m92	209	28	early	early	JJ
cord-262445-54ng7m92	209	29	disease	disease	NN
cord-262445-54ng7m92	209	30	.	.	.
cord-262445-54ng7m92	210	1	However	however	RB
cord-262445-54ng7m92	210	2	,	,	,
cord-262445-54ng7m92	210	3	during	during	IN
cord-262445-54ng7m92	210	4	late	late	JJ
cord-262445-54ng7m92	210	5	disease	disease	NN
cord-262445-54ng7m92	210	6	,	,	,
cord-262445-54ng7m92	210	7	lack	lack	NN
cord-262445-54ng7m92	210	8	of	of	IN
cord-262445-54ng7m92	210	9	splenic	splenic	JJ
cord-262445-54ng7m92	210	10	Ly6C	ly6c	JJ
cord-262445-54ng7m92	210	11	hi	hi	UH
cord-262445-54ng7m92	210	12	monocytes	monocyte	NNS
cord-262445-54ng7m92	210	13	adversely	adversely	RB
cord-262445-54ng7m92	210	14	affected	affect	VBN
cord-262445-54ng7m92	210	15	muscle	muscle	NN
cord-262445-54ng7m92	210	16	fiber	fiber	NN
cord-262445-54ng7m92	210	17	repair	repair	NN
cord-262445-54ng7m92	210	18	,	,	,
cord-262445-54ng7m92	210	19	caused	cause	VBD
cord-262445-54ng7m92	210	20	a	a	DT
cord-262445-54ng7m92	210	21	delay	delay	NN
cord-262445-54ng7m92	210	22	in	in	IN
cord-262445-54ng7m92	210	23	the	the	DT
cord-262445-54ng7m92	210	24	phenotypic	phenotypic	JJ
cord-262445-54ng7m92	210	25	shift	shift	NN
cord-262445-54ng7m92	210	26	of	of	IN
cord-262445-54ng7m92	210	27	pro	pro	JJ
cord-262445-54ng7m92	210	28	-	-	JJ
cord-262445-54ng7m92	210	29	inflammatory	inflammatory	JJ
cord-262445-54ng7m92	210	30	F4/80	F4/80	NNS
cord-262445-54ng7m92	211	1	+	+	CC
cord-262445-54ng7m92	212	1	/Ly6C	/Ly6C	.
cord-262445-54ng7m92	213	1	hi	hi	UH
cord-262445-54ng7m92	213	2	/CD206	/CD206	.
cord-262445-54ng7m92	214	1	lo	lo	NNP
cord-262445-54ng7m92	214	2	to	to	IN
cord-262445-54ng7m92	214	3	anti	anti	JJ
cord-262445-54ng7m92	214	4	-	-	JJ
cord-262445-54ng7m92	214	5	inflammatory	inflammatory	JJ
cord-262445-54ng7m92	214	6	F4/80	F4/80	NNS
cord-262445-54ng7m92	215	1	+	+	CC
cord-262445-54ng7m92	216	1	/Ly6C	/Ly6C	NFP
cord-262445-54ng7m92	216	2	lo	lo	NNP
cord-262445-54ng7m92	216	3	/CD206	/CD206	.
cord-262445-54ng7m92	217	1	+	+	CC
cord-262445-54ng7m92	217	2	macrophages	macrophage	NNS
cord-262445-54ng7m92	217	3	,	,	,
cord-262445-54ng7m92	217	4	and	and	CC
cord-262445-54ng7m92	217	5	was	be	VBD
cord-262445-54ng7m92	217	6	associated	associate	VBN
cord-262445-54ng7m92	217	7	with	with	IN
cord-262445-54ng7m92	217	8	increased	increase	VBN
cord-262445-54ng7m92	217	9	fibrosis	fibrosis	NN
cord-262445-54ng7m92	217	10	.	.	.
cord-262445-54ng7m92	218	1	Overall	overall	RB
cord-262445-54ng7m92	218	2	,	,	,
cord-262445-54ng7m92	218	3	we	-PRON-	PRP
cord-262445-54ng7m92	218	4	show	show	VBP
cord-262445-54ng7m92	218	5	that	that	IN
cord-262445-54ng7m92	218	6	the	the	DT
cord-262445-54ng7m92	218	7	spleen	spleen	NN
cord-262445-54ng7m92	218	8	is	be	VBZ
cord-262445-54ng7m92	218	9	an	an	DT
cord-262445-54ng7m92	218	10	indispensable	indispensable	JJ
cord-262445-54ng7m92	218	11	source	source	NN
cord-262445-54ng7m92	218	12	of	of	IN
cord-262445-54ng7m92	218	13	Ly6C	ly6c	JJ
cord-262445-54ng7m92	218	14	hi	hi	UH
cord-262445-54ng7m92	218	15	monocytes	monocyte	NNS
cord-262445-54ng7m92	218	16	in	in	IN
cord-262445-54ng7m92	218	17	muscular	muscular	JJ
cord-262445-54ng7m92	218	18	dystrophy	dystrophy	NN
cord-262445-54ng7m92	218	19	,	,	,
cord-262445-54ng7m92	218	20	and	and	CC
cord-262445-54ng7m92	218	21	that	that	IN
cord-262445-54ng7m92	218	22	splenic	splenic	JJ
cord-262445-54ng7m92	218	23	monocytes	monocyte	NNS
cord-262445-54ng7m92	218	24	are	be	VBP
cord-262445-54ng7m92	218	25	critical	critical	JJ
cord-262445-54ng7m92	218	26	players	player	NNS
cord-262445-54ng7m92	218	27	in	in	IN
cord-262445-54ng7m92	218	28	both	both	DT
cord-262445-54ng7m92	218	29	muscle	muscle	NN
cord-262445-54ng7m92	218	30	fiber	fiber	NN
cord-262445-54ng7m92	218	31	injury	injury	NN
cord-262445-54ng7m92	218	32	and	and	CC
cord-262445-54ng7m92	218	33	repair	repair	NN
cord-262445-54ng7m92	218	34	.	.	.
cord-262445-54ng7m92	219	1	Muscular	muscular	JJ
cord-262445-54ng7m92	219	2	Dystrophies	Dystrophies	NNPS
cord-262445-54ng7m92	219	3	(	(	-LRB-
cord-262445-54ng7m92	219	4	MDs	MDs	NNP
cord-262445-54ng7m92	219	5	)	)	-RRB-
cord-262445-54ng7m92	219	6	are	be	VBP
cord-262445-54ng7m92	219	7	severe	severe	JJ
cord-262445-54ng7m92	219	8	genetic	genetic	JJ
cord-262445-54ng7m92	219	9	disorders	disorder	NNS
cord-262445-54ng7m92	219	10	mainly	mainly	RB
cord-262445-54ng7m92	219	11	due	due	JJ
cord-262445-54ng7m92	219	12	to	to	IN
cord-262445-54ng7m92	219	13	mutations	mutation	NNS
cord-262445-54ng7m92	219	14	in	in	IN
cord-262445-54ng7m92	219	15	structural	structural	JJ
cord-262445-54ng7m92	219	16	proteins	protein	NNS
cord-262445-54ng7m92	219	17	,	,	,
cord-262445-54ng7m92	219	18	causing	cause	VBG
cord-262445-54ng7m92	219	19	contraction	contraction	NN
cord-262445-54ng7m92	219	20	-	-	HYPH
cord-262445-54ng7m92	219	21	induced	induce	VBN
cord-262445-54ng7m92	219	22	damages	damage	NNS
cord-262445-54ng7m92	219	23	.	.	.
cord-262445-54ng7m92	220	1	Previous	previous	JJ
cord-262445-54ng7m92	220	2	attempts	attempt	NNS
cord-262445-54ng7m92	220	3	to	to	TO
cord-262445-54ng7m92	220	4	treat	treat	VB
cord-262445-54ng7m92	220	5	these	these	DT
cord-262445-54ng7m92	220	6	diseases	disease	NNS
cord-262445-54ng7m92	220	7	raised	raise	VBN
cord-262445-54ng7m92	220	8	from	from	IN
cord-262445-54ng7m92	220	9	the	the	DT
cord-262445-54ng7m92	220	10	idea	idea	NN
cord-262445-54ng7m92	220	11	that	that	IN
cord-262445-54ng7m92	220	12	accelerating	accelerate	VBG
cord-262445-54ng7m92	220	13	muscle	muscle	NN
cord-262445-54ng7m92	220	14	growth	growth	NN
cord-262445-54ng7m92	220	15	and	and	CC
cord-262445-54ng7m92	220	16	regeneration	regeneration	NN
cord-262445-54ng7m92	220	17	would	would	MD
cord-262445-54ng7m92	220	18	exert	exert	VB
cord-262445-54ng7m92	220	19	beneficial	beneficial	JJ
cord-262445-54ng7m92	220	20	effects	effect	NNS
cord-262445-54ng7m92	220	21	.	.	.
cord-262445-54ng7m92	221	1	We	-PRON-	PRP
cord-262445-54ng7m92	221	2	recently	recently	RB
cord-262445-54ng7m92	221	3	demonstrated	demonstrate	VBD
cord-262445-54ng7m92	221	4	that	that	IN
cord-262445-54ng7m92	221	5	slowing	slow	VBG
cord-262445-54ng7m92	221	6	down	down	IN
cord-262445-54ng7m92	221	7	the	the	DT
cord-262445-54ng7m92	221	8	degeneration	degeneration	NN
cord-262445-54ng7m92	221	9	-	-	HYPH
cord-262445-54ng7m92	221	10	regeneration	regeneration	NN
cord-262445-54ng7m92	221	11	cycles	cycle	NNS
cord-262445-54ng7m92	221	12	and	and	CC
cord-262445-54ng7m92	221	13	switching	switch	VBG
cord-262445-54ng7m92	221	14	muscle	muscle	NN
cord-262445-54ng7m92	221	15	fibers	fiber	NNS
cord-262445-54ng7m92	221	16	towards	towards	IN
cord-262445-54ng7m92	221	17	a	a	DT
cord-262445-54ng7m92	221	18	slow	slow	RB
cord-262445-54ng7m92	221	19	-	-	HYPH
cord-262445-54ng7m92	221	20	twitching	twitch	VBG
cord-262445-54ng7m92	221	21	phenotype	phenotype	NN
cord-262445-54ng7m92	221	22	by	by	IN
cord-262445-54ng7m92	221	23	silencing	silence	VBG
cord-262445-54ng7m92	221	24	the	the	DT
cord-262445-54ng7m92	221	25	transcription	transcription	NN
cord-262445-54ng7m92	221	26	factor	factor	NN
cord-262445-54ng7m92	222	1	Nfix	Nfix	NNP
cord-262445-54ng7m92	222	2	leads	lead	VBZ
cord-262445-54ng7m92	222	3	to	to	IN
cord-262445-54ng7m92	222	4	a	a	DT
cord-262445-54ng7m92	222	5	morphological	morphological	JJ
cord-262445-54ng7m92	222	6	and	and	CC
cord-262445-54ng7m92	222	7	functional	functional	JJ
cord-262445-54ng7m92	222	8	amelioration	amelioration	NN
cord-262445-54ng7m92	222	9	of	of	IN
cord-262445-54ng7m92	222	10	the	the	DT
cord-262445-54ng7m92	222	11	dystrophic	dystrophic	JJ
cord-262445-54ng7m92	222	12	phenotype	phenotype	NN
cord-262445-54ng7m92	222	13	.	.	.
cord-262445-54ng7m92	223	1	On	on	IN
cord-262445-54ng7m92	223	2	the	the	DT
cord-262445-54ng7m92	223	3	basis	basis	NN
cord-262445-54ng7m92	223	4	of	of	IN
cord-262445-54ng7m92	223	5	the	the	DT
cord-262445-54ng7m92	223	6	identification	identification	NN
cord-262445-54ng7m92	223	7	of	of	IN
cord-262445-54ng7m92	223	8	the	the	DT
cord-262445-54ng7m92	223	9	molecular	molecular	JJ
cord-262445-54ng7m92	223	10	pathways	pathway	NNS
cord-262445-54ng7m92	223	11	regulating	regulate	VBG
cord-262445-54ng7m92	223	12	Nfix	Nfix	NNP
cord-262445-54ng7m92	223	13	expression	expression	NN
cord-262445-54ng7m92	223	14	,	,	,
cord-262445-54ng7m92	223	15	we	-PRON-	PRP
cord-262445-54ng7m92	223	16	are	be	VBP
cord-262445-54ng7m92	223	17	now	now	RB
cord-262445-54ng7m92	223	18	developing	develop	VBG
cord-262445-54ng7m92	223	19	a	a	DT
cord-262445-54ng7m92	223	20	pharmacological	pharmacological	JJ
cord-262445-54ng7m92	223	21	approach	approach	NN
cord-262445-54ng7m92	223	22	to	to	TO
cord-262445-54ng7m92	223	23	inhibit	inhibit	VB
cord-262445-54ng7m92	223	24	Nfix	Nfix	NNP
cord-262445-54ng7m92	223	25	in	in	IN
cord-262445-54ng7m92	223	26	MDs	MDs	NNP
cord-262445-54ng7m92	223	27	which	which	WDT
cord-262445-54ng7m92	223	28	is	be	VBZ
cord-262445-54ng7m92	223	29	based	base	VBN
cord-262445-54ng7m92	223	30	on	on	IN
cord-262445-54ng7m92	223	31	the	the	DT
cord-262445-54ng7m92	223	32	inhibition	inhibition	NN
cord-262445-54ng7m92	223	33	of	of	IN
cord-262445-54ng7m92	223	34	the	the	DT
cord-262445-54ng7m92	223	35	ERK	ERK	NNP
cord-262445-54ng7m92	223	36	pathway	pathway	NN
cord-262445-54ng7m92	223	37	by	by	IN
cord-262445-54ng7m92	223	38	using	use	VBG
cord-262445-54ng7m92	223	39	two	two	CD
cord-262445-54ng7m92	223	40	FDA	FDA	NNP
cord-262445-54ng7m92	223	41	-	-	HYPH
cord-262445-54ng7m92	223	42	and	and	CC
cord-262445-54ng7m92	223	43	EMA	EMA	NNP
cord-262445-54ng7m92	223	44	approved	approve	VBD
cord-262445-54ng7m92	223	45	drugs	drug	NNS
cord-262445-54ng7m92	223	46	for	for	IN
cord-262445-54ng7m92	223	47	cancer	cancer	NN
cord-262445-54ng7m92	223	48	.	.	.
cord-262445-54ng7m92	224	1	At	at	IN
cord-262445-54ng7m92	224	2	the	the	DT
cord-262445-54ng7m92	224	3	same	same	JJ
cord-262445-54ng7m92	224	4	time	time	NN
cord-262445-54ng7m92	224	5	,	,	,
cord-262445-54ng7m92	224	6	another	another	DT
cord-262445-54ng7m92	224	7	strategy	strategy	NN
cord-262445-54ng7m92	224	8	considered	consider	VBN
cord-262445-54ng7m92	224	9	is	be	VBZ
cord-262445-54ng7m92	224	10	the	the	DT
cord-262445-54ng7m92	224	11	use	use	NN
cord-262445-54ng7m92	224	12	of	of	IN
cord-262445-54ng7m92	224	13	antioxidants	antioxidant	NNS
cord-262445-54ng7m92	224	14	to	to	TO
cord-262445-54ng7m92	224	15	protect	protect	VB
cord-262445-54ng7m92	224	16	myofibers	myofiber	NNS
cord-262445-54ng7m92	224	17	from	from	IN
cord-262445-54ng7m92	224	18	oxidative	oxidative	JJ
cord-262445-54ng7m92	224	19	stress	stress	NN
cord-262445-54ng7m92	224	20	generated	generate	VBN
cord-262445-54ng7m92	224	21	by	by	IN
cord-262445-54ng7m92	224	22	muscular	muscular	JJ
cord-262445-54ng7m92	224	23	contraction	contraction	NN
cord-262445-54ng7m92	224	24	.	.	.
cord-262445-54ng7m92	225	1	Different	different	JJ
cord-262445-54ng7m92	225	2	evidences	evidence	NNS
cord-262445-54ng7m92	225	3	are	be	VBP
cord-262445-54ng7m92	225	4	indeed	indeed	RB
cord-262445-54ng7m92	225	5	establishing	establish	VBG
cord-262445-54ng7m92	225	6	the	the	DT
cord-262445-54ng7m92	225	7	importance	importance	NN
cord-262445-54ng7m92	225	8	of	of	IN
cord-262445-54ng7m92	225	9	dietary	dietary	JJ
cord-262445-54ng7m92	225	10	anthocyanin	anthocyanin	NN
cord-262445-54ng7m92	225	11	's	's	POS
cord-262445-54ng7m92	225	12	for	for	IN
cord-262445-54ng7m92	225	13	preventive	preventive	JJ
cord-262445-54ng7m92	225	14	and	and	CC
cord-262445-54ng7m92	225	15	ameliorative	ameliorative	JJ
cord-262445-54ng7m92	225	16	strategies	strategy	NNS
cord-262445-54ng7m92	225	17	against	against	IN
cord-262445-54ng7m92	225	18	chronic	chronic	JJ
cord-262445-54ng7m92	225	19	diseases	disease	NNS
cord-262445-54ng7m92	225	20	.	.	.
cord-262445-54ng7m92	226	1	We	-PRON-	PRP
cord-262445-54ng7m92	226	2	therefore	therefore	RB
cord-262445-54ng7m92	226	3	tested	test	VBD
cord-262445-54ng7m92	226	4	the	the	DT
cord-262445-54ng7m92	226	5	therapeutic	therapeutic	JJ
cord-262445-54ng7m92	226	6	benefit	benefit	NN
cord-262445-54ng7m92	226	7	of	of	IN
cord-262445-54ng7m92	226	8	a	a	DT
cord-262445-54ng7m92	226	9	cyanidinenriched	cyanidinenriched	JJ
cord-262445-54ng7m92	226	10	diet	diet	NN
cord-262445-54ng7m92	226	11	in	in	IN
cord-262445-54ng7m92	226	12	the	the	DT
cord-262445-54ng7m92	226	13	progression	progression	NN
cord-262445-54ng7m92	226	14	of	of	IN
cord-262445-54ng7m92	226	15	the	the	DT
cord-262445-54ng7m92	226	16	MD	MD	NNP
cord-262445-54ng7m92	226	17	.	.	.
cord-262445-54ng7m92	227	1	Interestingly	interestingly	RB
cord-262445-54ng7m92	227	2	,	,	,
cord-262445-54ng7m92	227	3	dystrophic	dystrophic	JJ
cord-262445-54ng7m92	227	4	mice	mouse	NNS
cord-262445-54ng7m92	227	5	fed	feed	VBN
cord-262445-54ng7m92	227	6	with	with	IN
cord-262445-54ng7m92	227	7	a	a	DT
cord-262445-54ng7m92	227	8	cyanidin	cyanidin	NN
cord-262445-54ng7m92	227	9	-	-	HYPH
cord-262445-54ng7m92	227	10	enriched	enrich	VBN
cord-262445-54ng7m92	227	11	diet	diet	NN
cord-262445-54ng7m92	227	12	show	show	VBP
cord-262445-54ng7m92	227	13	a	a	DT
cord-262445-54ng7m92	227	14	morphological	morphological	JJ
cord-262445-54ng7m92	227	15	and	and	CC
cord-262445-54ng7m92	227	16	functional	functional	JJ
cord-262445-54ng7m92	227	17	amelioration	amelioration	NN
cord-262445-54ng7m92	227	18	of	of	IN
cord-262445-54ng7m92	227	19	the	the	DT
cord-262445-54ng7m92	227	20	dystrophic	dystrophic	JJ
cord-262445-54ng7m92	227	21	phenotype	phenotype	NN
cord-262445-54ng7m92	227	22	through	through	IN
cord-262445-54ng7m92	227	23	mechanisms	mechanism	NNS
cord-262445-54ng7m92	227	24	that	that	WDT
cord-262445-54ng7m92	227	25	involve	involve	VBP
cord-262445-54ng7m92	227	26	both	both	DT
cord-262445-54ng7m92	227	27	cell	cell	NN
cord-262445-54ng7m92	227	28	survival	survival	NN
cord-262445-54ng7m92	227	29	and	and	CC
cord-262445-54ng7m92	227	30	anti	anti	JJ
cord-262445-54ng7m92	227	31	-	-	JJ
cord-262445-54ng7m92	227	32	inflammatory	inflammatory	JJ
cord-262445-54ng7m92	227	33	pathways	pathway	NNS
cord-262445-54ng7m92	227	34	.	.	.
cord-262445-54ng7m92	228	1	All	all	PDT
cord-262445-54ng7m92	228	2	this	this	DT
cord-262445-54ng7m92	228	3	evidence	evidence	NN
cord-262445-54ng7m92	228	4	,	,	,
cord-262445-54ng7m92	228	5	strongly	strongly	RB
cord-262445-54ng7m92	228	6	demonstrate	demonstrate	VB
cord-262445-54ng7m92	228	7	that	that	IN
cord-262445-54ng7m92	228	8	promising	promise	VBG
cord-262445-54ng7m92	228	9	therapeutic	therapeutic	JJ
cord-262445-54ng7m92	228	10	and	and	CC
cord-262445-54ng7m92	228	11	supporting	support	VBG
cord-262445-54ng7m92	228	12	strategies	strategy	NNS
cord-262445-54ng7m92	228	13	to	to	TO
cord-262445-54ng7m92	228	14	slow	slow	VB
cord-262445-54ng7m92	228	15	down	down	RP
cord-262445-54ng7m92	228	16	the	the	DT
cord-262445-54ng7m92	228	17	disease	disease	NN
cord-262445-54ng7m92	228	18	progression	progression	NN
cord-262445-54ng7m92	228	19	in	in	IN
cord-262445-54ng7m92	228	20	dystrophic	dystrophic	JJ
cord-262445-54ng7m92	228	21	patients	patient	NNS
cord-262445-54ng7m92	228	22	is	be	VBZ
cord-262445-54ng7m92	228	23	to	to	TO
cord-262445-54ng7m92	228	24	reduce	reduce	VB
cord-262445-54ng7m92	228	25	,	,	,
cord-262445-54ng7m92	228	26	the	the	DT
cord-262445-54ng7m92	228	27	oxidative	oxidative	JJ
cord-262445-54ng7m92	228	28	stress	stress	NN
cord-262445-54ng7m92	228	29	,	,	,
cord-262445-54ng7m92	228	30	muscle	muscle	NN
cord-262445-54ng7m92	228	31	regeneration	regeneration	NN
cord-262445-54ng7m92	228	32	and	and	CC
cord-262445-54ng7m92	228	33	muscle	muscle	NN
cord-262445-54ng7m92	228	34	contraction	contraction	NN
cord-262445-54ng7m92	228	35	achievable	achievable	JJ
cord-262445-54ng7m92	228	36	through	through	IN
cord-262445-54ng7m92	228	37	different	different	JJ
cord-262445-54ng7m92	228	38	and	and	CC
cord-262445-54ng7m92	228	39	synergistic	synergistic	JJ
cord-262445-54ng7m92	228	40	strategies	strategy	NNS
cord-262445-54ng7m92	228	41	.	.	.
cord-262445-54ng7m92	228	42	 	 	_SP
cord-262445-54ng7m92	229	1	profiled	profile	VBN
cord-262445-54ng7m92	229	2	both	both	CC
cord-262445-54ng7m92	229	3	the	the	DT
cord-262445-54ng7m92	229	4	cytokines	cytokine	NNS
cord-262445-54ng7m92	229	5	and	and	CC
cord-262445-54ng7m92	229	6	the	the	DT
cord-262445-54ng7m92	229	7	EVs	ev	NNS
cord-262445-54ng7m92	229	8	at	at	IN
cord-262445-54ng7m92	229	9	different	different	JJ
cord-262445-54ng7m92	229	10	time	time	NN
cord-262445-54ng7m92	229	11	points	point	NNS
cord-262445-54ng7m92	229	12	during	during	IN
cord-262445-54ng7m92	229	13	muscle	muscle	NN
cord-262445-54ng7m92	229	14	regeneration	regeneration	NN
cord-262445-54ng7m92	229	15	of	of	IN
cord-262445-54ng7m92	229	16	the	the	DT
cord-262445-54ng7m92	229	17	cardiotoxin	cardiotoxin	NNP
cord-262445-54ng7m92	229	18	injured	injure	VBN
cord-262445-54ng7m92	229	19	mouse	mouse	NN
cord-262445-54ng7m92	229	20	model	model	NN
cord-262445-54ng7m92	229	21	.	.	.
cord-262445-54ng7m92	230	1	We	-PRON-	PRP
cord-262445-54ng7m92	230	2	performed	perform	VBD
cord-262445-54ng7m92	230	3	a	a	DT
cord-262445-54ng7m92	230	4	multiplex	multiplex	NN
cord-262445-54ng7m92	230	5	ELISA	ELISA	NNP
cord-262445-54ng7m92	230	6	assay	assay	NN
cord-262445-54ng7m92	230	7	of	of	IN
cord-262445-54ng7m92	230	8	the	the	DT
cord-262445-54ng7m92	230	9	mononuclear	mononuclear	JJ
cord-262445-54ng7m92	230	10	cell	cell	NN
cord-262445-54ng7m92	230	11	compartment	compartment	NN
cord-262445-54ng7m92	230	12	lysate	lysate	NN
cord-262445-54ng7m92	230	13	to	to	TO
cord-262445-54ng7m92	230	14	analyze	analyze	VB
cord-262445-54ng7m92	230	15	the	the	DT
cord-262445-54ng7m92	230	16	expression	expression	NN
cord-262445-54ng7m92	230	17	kinetics	kinetics	NN
cord-262445-54ng7m92	230	18	of	of	IN
cord-262445-54ng7m92	230	19	90	90	CD
cord-262445-54ng7m92	230	20	cytokines	cytokine	NNS
cord-262445-54ng7m92	230	21	.	.	.
cord-262445-54ng7m92	231	1	In	in	IN
cord-262445-54ng7m92	231	2	addition	addition	NN
cord-262445-54ng7m92	231	3	,	,	,
cord-262445-54ng7m92	231	4	by	by	IN
cord-262445-54ng7m92	231	5	profiling	profile	VBG
cord-262445-54ng7m92	231	6	the	the	DT
cord-262445-54ng7m92	231	7	RNA	RNA	NNP
cord-262445-54ng7m92	231	8	expression	expression	NN
cord-262445-54ng7m92	231	9	profile	profile	NN
cord-262445-54ng7m92	231	10	of	of	IN
cord-262445-54ng7m92	231	11	four	four	CD
cord-262445-54ng7m92	231	12	cell	cell	NN
cord-262445-54ng7m92	231	13	populations	population	NNS
cord-262445-54ng7m92	231	14	,	,	,
cord-262445-54ng7m92	231	15	we	-PRON-	PRP
cord-262445-54ng7m92	231	16	determined	determine	VBD
cord-262445-54ng7m92	231	17	the	the	DT
cord-262445-54ng7m92	231	18	cell	cell	NN
cord-262445-54ng7m92	231	19	types	type	NNS
cord-262445-54ng7m92	231	20	that	that	WDT
cord-262445-54ng7m92	231	21	have	have	VBP
cord-262445-54ng7m92	231	22	the	the	DT
cord-262445-54ng7m92	231	23	potential	potential	NN
cord-262445-54ng7m92	231	24	to	to	TO
cord-262445-54ng7m92	231	25	secrete	secrete	VB
cord-262445-54ng7m92	231	26	the	the	DT
cord-262445-54ng7m92	231	27	different	different	JJ
cord-262445-54ng7m92	231	28	cytokines	cytokine	NNS
cord-262445-54ng7m92	231	29	and	and	CC
cord-262445-54ng7m92	231	30	those	those	DT
cord-262445-54ng7m92	231	31	that	that	WDT
cord-262445-54ng7m92	231	32	synthetize	synthetize	VBP
cord-262445-54ng7m92	231	33	the	the	DT
cord-262445-54ng7m92	231	34	specific	specific	JJ
cord-262445-54ng7m92	231	35	receptors	receptor	NNS
cord-262445-54ng7m92	231	36	.	.	.
cord-262445-54ng7m92	232	1	Based	base	VBN
cord-262445-54ng7m92	232	2	on	on	IN
cord-262445-54ng7m92	232	3	the	the	DT
cord-262445-54ng7m92	232	4	kinetic	kinetic	NN
cord-262445-54ng7m92	232	5	of	of	IN
cord-262445-54ng7m92	232	6	their	-PRON-	PRP$
cord-262445-54ng7m92	232	7	expression	expression	NN
cord-262445-54ng7m92	232	8	during	during	IN
cord-262445-54ng7m92	232	9	damage	damage	NN
cord-262445-54ng7m92	232	10	recovery	recovery	NN
cord-262445-54ng7m92	232	11	,	,	,
cord-262445-54ng7m92	232	12	we	-PRON-	PRP
cord-262445-54ng7m92	232	13	selected	select	VBD
cord-262445-54ng7m92	232	14	15	15	CD
cord-262445-54ng7m92	232	15	cytokines	cytokine	NNS
cord-262445-54ng7m92	232	16	to	to	TO
cord-262445-54ng7m92	232	17	be	be	VB
cord-262445-54ng7m92	232	18	tested	test	VBN
cord-262445-54ng7m92	232	19	in	in	IN
cord-262445-54ng7m92	232	20	vitro	vitro	FW
cord-262445-54ng7m92	232	21	on	on	IN
cord-262445-54ng7m92	232	22	fibro	fibro	NN
cord-262445-54ng7m92	232	23	-	-	HYPH
cord-262445-54ng7m92	232	24	adipogenic	adipogenic	JJ
cord-262445-54ng7m92	232	25	progenitors	progenitor	NNS
cord-262445-54ng7m92	232	26	(	(	-LRB-
cord-262445-54ng7m92	232	27	FAPs	FAPs	NNP
cord-262445-54ng7m92	232	28	)	)	-RRB-
cord-262445-54ng7m92	232	29	.	.	.
cord-262445-54ng7m92	233	1	Using	use	VBG
cord-262445-54ng7m92	233	2	this	this	DT
cord-262445-54ng7m92	233	3	approach	approach	NN
cord-262445-54ng7m92	233	4	we	-PRON-	PRP
cord-262445-54ng7m92	233	5	identified	identify	VBD
cord-262445-54ng7m92	233	6	cytokines	cytokine	NNS
cord-262445-54ng7m92	233	7	that	that	WDT
cord-262445-54ng7m92	233	8	influence	influence	VBP
cord-262445-54ng7m92	233	9	FAP	fap	NN
cord-262445-54ng7m92	233	10	proliferation	proliferation	NN
cord-262445-54ng7m92	233	11	and	and	CC
cord-262445-54ng7m92	233	12	differentiation	differentiation	NN
cord-262445-54ng7m92	233	13	decisions	decision	NNS
cord-262445-54ng7m92	233	14	.	.	.
cord-262445-54ng7m92	234	1	In	in	IN
cord-262445-54ng7m92	234	2	addition	addition	NN
cord-262445-54ng7m92	234	3	,	,	,
cord-262445-54ng7m92	234	4	by	by	IN
cord-262445-54ng7m92	234	5	culturing	culture	VBG
cord-262445-54ng7m92	234	6	injured	injure	VBN
cord-262445-54ng7m92	234	7	muscles	muscle	NNS
cord-262445-54ng7m92	234	8	ex	ex	NN
cord-262445-54ng7m92	234	9	-	-	NN
cord-262445-54ng7m92	234	10	vivo	vivo	NN
cord-262445-54ng7m92	234	11	,	,	,
cord-262445-54ng7m92	234	12	we	-PRON-	PRP
cord-262445-54ng7m92	234	13	obtained	obtain	VBD
cord-262445-54ng7m92	234	14	the	the	DT
cord-262445-54ng7m92	234	15	EVs	ev	NNS
cord-262445-54ng7m92	234	16	secreted	secrete	VBN
cord-262445-54ng7m92	234	17	by	by	IN
cord-262445-54ng7m92	234	18	the	the	DT
cord-262445-54ng7m92	234	19	tissue	tissue	NN
cord-262445-54ng7m92	234	20	during	during	IN
cord-262445-54ng7m92	234	21	the	the	DT
cord-262445-54ng7m92	234	22	regeneration	regeneration	NN
cord-262445-54ng7m92	234	23	process	process	NN
cord-262445-54ng7m92	234	24	.	.	.
cord-262445-54ng7m92	235	1	To	to	TO
cord-262445-54ng7m92	235	2	analyze	analyze	VB
cord-262445-54ng7m92	235	3	their	-PRON-	PRP$
cord-262445-54ng7m92	235	4	cargo	cargo	NN
cord-262445-54ng7m92	235	5	,	,	,
cord-262445-54ng7m92	235	6	we	-PRON-	PRP
cord-262445-54ng7m92	235	7	characterized	characterize	VBD
cord-262445-54ng7m92	235	8	the	the	DT
cord-262445-54ng7m92	235	9	vesicle	vesicle	NN
cord-262445-54ng7m92	235	10	heterogeneity	heterogeneity	NN
cord-262445-54ng7m92	235	11	by	by	IN
cord-262445-54ng7m92	235	12	using	use	VBG
cord-262445-54ng7m92	235	13	a	a	DT
cord-262445-54ng7m92	235	14	flow	flow	NN
cord-262445-54ng7m92	235	15	cytometry	cytometry	NN
cord-262445-54ng7m92	235	16	approach	approach	NN
cord-262445-54ng7m92	235	17	.	.	.
cord-262445-54ng7m92	236	1	Specifically	specifically	RB
cord-262445-54ng7m92	236	2	,	,	,
cord-262445-54ng7m92	236	3	we	-PRON-	PRP
cord-262445-54ng7m92	236	4	identified	identify	VBD
cord-262445-54ng7m92	236	5	and	and	CC
cord-262445-54ng7m92	236	6	quantified	quantify	VBD
cord-262445-54ng7m92	236	7	the	the	DT
cord-262445-54ng7m92	236	8	RNAs	rna	NNS
cord-262445-54ng7m92	236	9	-	-	:
cord-262445-54ng7m92	236	10	and	and	CC
cord-262445-54ng7m92	236	11	enzymes	enzyme	NNS
cord-262445-54ng7m92	236	12	-	-	HYPH
cord-262445-54ng7m92	236	13	containing	contain	VBG
cord-262445-54ng7m92	236	14	EVs	ev	NNS
cord-262445-54ng7m92	236	15	.	.	.
cord-262445-54ng7m92	237	1	Finally	finally	RB
cord-262445-54ng7m92	237	2	,	,	,
cord-262445-54ng7m92	237	3	we	-PRON-	PRP
cord-262445-54ng7m92	237	4	investigated	investigate	VBD
cord-262445-54ng7m92	237	5	their	-PRON-	PRP$
cord-262445-54ng7m92	237	6	ability	ability	NN
cord-262445-54ng7m92	237	7	to	to	TO
cord-262445-54ng7m92	237	8	interact	interact	VB
cord-262445-54ng7m92	237	9	with	with	IN
cord-262445-54ng7m92	237	10	different	different	JJ
cord-262445-54ng7m92	237	11	muscle	muscle	NN
cord-262445-54ng7m92	237	12	-	-	HYPH
cord-262445-54ng7m92	237	13	derived	derive	VBN
cord-262445-54ng7m92	237	14	cell	cell	NN
cord-262445-54ng7m92	237	15	populations	population	NNS
cord-262445-54ng7m92	237	16	,	,	,
cord-262445-54ng7m92	237	17	influencing	influence	VBG
cord-262445-54ng7m92	237	18	their	-PRON-	PRP$
cord-262445-54ng7m92	237	19	proliferation	proliferation	NN
cord-262445-54ng7m92	237	20	and	and	CC
cord-262445-54ng7m92	237	21	differentiation	differentiation	NN
cord-262445-54ng7m92	237	22	potential	potential	NN
cord-262445-54ng7m92	237	23	.	.	.
cord-262445-54ng7m92	238	1	Our	-PRON-	PRP$
cord-262445-54ng7m92	238	2	data	datum	NNS
cord-262445-54ng7m92	238	3	,	,	,
cord-262445-54ng7m92	238	4	combined	combine	VBN
cord-262445-54ng7m92	238	5	with	with	IN
cord-262445-54ng7m92	238	6	in	in	IN
cord-262445-54ng7m92	238	7	silico	silico	NN
cord-262445-54ng7m92	238	8	modeling	modeling	NN
cord-262445-54ng7m92	238	9	,	,	,
cord-262445-54ng7m92	238	10	will	will	MD
cord-262445-54ng7m92	238	11	increase	increase	VB
cord-262445-54ng7m92	238	12	our	-PRON-	PRP$
cord-262445-54ng7m92	238	13	understanding	understanding	NN
cord-262445-54ng7m92	238	14	of	of	IN
cord-262445-54ng7m92	238	15	cell	cell	NN
cord-262445-54ng7m92	238	16	-	-	HYPH
cord-262445-54ng7m92	238	17	cell	cell	NN
cord-262445-54ng7m92	238	18	communication	communication	NN
cord-262445-54ng7m92	238	19	during	during	IN
cord-262445-54ng7m92	238	20	muscle	muscle	NN
cord-262445-54ng7m92	238	21	regeneration	regeneration	NN
cord-262445-54ng7m92	238	22	.	.	.
cord-262445-54ng7m92	239	1	The	the	DT
cord-262445-54ng7m92	239	2	neuromuscular	neuromuscular	JJ
cord-262445-54ng7m92	239	3	junction	junction	NN
cord-262445-54ng7m92	239	4	(	(	-LRB-
cord-262445-54ng7m92	239	5	NMJ	NMJ	NNP
cord-262445-54ng7m92	239	6	)	)	-RRB-
cord-262445-54ng7m92	239	7	is	be	VBZ
cord-262445-54ng7m92	239	8	a	a	DT
cord-262445-54ng7m92	239	9	chemical	chemical	JJ
cord-262445-54ng7m92	239	10	synapse	synapse	NN
cord-262445-54ng7m92	239	11	localized	localize	VBN
cord-262445-54ng7m92	239	12	between	between	IN
cord-262445-54ng7m92	239	13	the	the	DT
cord-262445-54ng7m92	239	14	terminal	terminal	JJ
cord-262445-54ng7m92	239	15	branches	branch	NNS
cord-262445-54ng7m92	239	16	of	of	IN
cord-262445-54ng7m92	239	17	the	the	DT
cord-262445-54ng7m92	239	18	spinal	spinal	JJ
cord-262445-54ng7m92	239	19	motor	motor	NN
cord-262445-54ng7m92	239	20	neurons	neuron	NNS
cord-262445-54ng7m92	239	21	and	and	CC
cord-262445-54ng7m92	239	22	the	the	DT
cord-262445-54ng7m92	239	23	skeletal	skeletal	JJ
cord-262445-54ng7m92	239	24	muscle	muscle	NN
cord-262445-54ng7m92	239	25	fibers	fiber	NNS
cord-262445-54ng7m92	239	26	.	.	.
cord-262445-54ng7m92	240	1	In	in	IN
cord-262445-54ng7m92	240	2	the	the	DT
cord-262445-54ng7m92	240	3	past	past	JJ
cord-262445-54ng7m92	240	4	two	two	CD
cord-262445-54ng7m92	240	5	decades	decade	NNS
cord-262445-54ng7m92	240	6	co	co	NN
cord-262445-54ng7m92	240	7	-	-	JJ
cord-262445-54ng7m92	240	8	culture	culture	JJ
cord-262445-54ng7m92	240	9	systems	system	NNS
cord-262445-54ng7m92	240	10	to	to	TO
cord-262445-54ng7m92	240	11	recreate	recreate	VB
cord-262445-54ng7m92	240	12	the	the	DT
cord-262445-54ng7m92	240	13	NMJ	NMJ	NNP
cord-262445-54ng7m92	240	14	in	in	IN
cord-262445-54ng7m92	240	15	vitro	vitro	FW
cord-262445-54ng7m92	240	16	were	be	VBD
cord-262445-54ng7m92	240	17	developed	develop	VBN
cord-262445-54ng7m92	240	18	to	to	TO
cord-262445-54ng7m92	240	19	address	address	VB
cord-262445-54ng7m92	240	20	concerns	concern	NNS
cord-262445-54ng7m92	240	21	about	about	IN
cord-262445-54ng7m92	240	22	animal	animal	NN
cord-262445-54ng7m92	240	23	models	model	NNS
cord-262445-54ng7m92	240	24	,	,	,
cord-262445-54ng7m92	240	25	nevertheless	nevertheless	RB
cord-262445-54ng7m92	240	26	the	the	DT
cord-262445-54ng7m92	240	27	complexity	complexity	NN
cord-262445-54ng7m92	240	28	of	of	IN
cord-262445-54ng7m92	240	29	its	-PRON-	PRP$
cord-262445-54ng7m92	240	30	highly	highly	RB
cord-262445-54ng7m92	240	31	specialized	specialized	JJ
cord-262445-54ng7m92	240	32	structure	structure	NN
cord-262445-54ng7m92	240	33	makes	make	VBZ
cord-262445-54ng7m92	240	34	the	the	DT
cord-262445-54ng7m92	240	35	in	in	FW
cord-262445-54ng7m92	240	36	vitro	vitro	FW
cord-262445-54ng7m92	240	37	modeling	model	VBG
cord-262445-54ng7m92	240	38	a	a	DT
cord-262445-54ng7m92	240	39	challenging	challenging	JJ
cord-262445-54ng7m92	240	40	task	task	NN
cord-262445-54ng7m92	240	41	.	.	.
cord-262445-54ng7m92	241	1	However	however	RB
cord-262445-54ng7m92	241	2	,	,	,
cord-262445-54ng7m92	241	3	a	a	DT
cord-262445-54ng7m92	241	4	further	further	JJ
cord-262445-54ng7m92	241	5	improvement	improvement	NN
cord-262445-54ng7m92	241	6	in	in	IN
cord-262445-54ng7m92	241	7	this	this	DT
cord-262445-54ng7m92	241	8	issue	issue	NN
cord-262445-54ng7m92	241	9	was	be	VBD
cord-262445-54ng7m92	241	10	recently	recently	RB
cord-262445-54ng7m92	241	11	provided	provide	VBN
cord-262445-54ng7m92	241	12	by	by	IN
cord-262445-54ng7m92	241	13	microfluidics	microfluidic	NNS
cord-262445-54ng7m92	241	14	that	that	WDT
cord-262445-54ng7m92	241	15	,	,	,
cord-262445-54ng7m92	241	16	unlike	unlike	IN
cord-262445-54ng7m92	241	17	in	in	IN
cord-262445-54ng7m92	241	18	mass	mass	JJ
cord-262445-54ng7m92	241	19	co	co	NNS
cord-262445-54ng7m92	241	20	-	-	NNS
cord-262445-54ng7m92	241	21	cultures	culture	NNS
cord-262445-54ng7m92	241	22	,	,	,
cord-262445-54ng7m92	241	23	allow	allow	VB
cord-262445-54ng7m92	241	24	spatial	spatial	JJ
cord-262445-54ng7m92	241	25	and	and	CC
cord-262445-54ng7m92	241	26	temporal	temporal	JJ
cord-262445-54ng7m92	241	27	control	control	NN
cord-262445-54ng7m92	241	28	over	over	IN
cord-262445-54ng7m92	241	29	different	different	JJ
cord-262445-54ng7m92	241	30	microenvironment	microenvironment	NN
cord-262445-54ng7m92	241	31	by	by	IN
cord-262445-54ng7m92	241	32	manipulating	manipulate	VBG
cord-262445-54ng7m92	241	33	either	either	DT
cord-262445-54ng7m92	241	34	neural	neural	JJ
cord-262445-54ng7m92	241	35	cells	cell	NNS
cord-262445-54ng7m92	241	36	or	or	CC
cord-262445-54ng7m92	241	37	muscle	muscle	NN
cord-262445-54ng7m92	241	38	cells	cell	NNS
cord-262445-54ng7m92	241	39	populations	population	NNS
cord-262445-54ng7m92	241	40	independently	independently	RB
cord-262445-54ng7m92	241	41	.	.	.
cord-262445-54ng7m92	242	1	This	this	DT
cord-262445-54ng7m92	242	2	enables	enable	VBZ
cord-262445-54ng7m92	242	3	the	the	DT
cord-262445-54ng7m92	242	4	investigation	investigation	NN
cord-262445-54ng7m92	242	5	of	of	IN
cord-262445-54ng7m92	242	6	mechanisms	mechanism	NNS
cord-262445-54ng7m92	242	7	involved	involve	VBN
cord-262445-54ng7m92	242	8	in	in	IN
cord-262445-54ng7m92	242	9	the	the	DT
cord-262445-54ng7m92	242	10	formation	formation	NN
cord-262445-54ng7m92	242	11	and	and	CC
cord-262445-54ng7m92	242	12	the	the	DT
cord-262445-54ng7m92	242	13	maintenance	maintenance	NN
cord-262445-54ng7m92	242	14	of	of	IN
cord-262445-54ng7m92	242	15	a	a	DT
cord-262445-54ng7m92	242	16	stable	stable	JJ
cord-262445-54ng7m92	242	17	and	and	CC
cord-262445-54ng7m92	242	18	functional	functional	JJ
cord-262445-54ng7m92	242	19	NMJ	NMJ	NNP
cord-262445-54ng7m92	242	20	.	.	.
cord-262445-54ng7m92	243	1	Therefore	therefore	RB
cord-262445-54ng7m92	243	2	,	,	,
cord-262445-54ng7m92	243	3	exploiting	exploit	VBG
cord-262445-54ng7m92	243	4	an	an	DT
cord-262445-54ng7m92	243	5	organ	organ	NN
cord-262445-54ng7m92	243	6	-	-	HYPH
cord-262445-54ng7m92	243	7	on	on	IN
cord-262445-54ng7m92	243	8	-	-	HYPH
cord-262445-54ng7m92	243	9	a	a	DT
cord-262445-54ng7m92	243	10	-	-	HYPH
cord-262445-54ng7m92	243	11	chip	chip	NN
cord-262445-54ng7m92	243	12	approach	approach	NN
cord-262445-54ng7m92	243	13	,	,	,
cord-262445-54ng7m92	243	14	our	-PRON-	PRP$
cord-262445-54ng7m92	243	15	aim	aim	NN
cord-262445-54ng7m92	243	16	is	be	VBZ
cord-262445-54ng7m92	243	17	to	to	TO
cord-262445-54ng7m92	243	18	obtain	obtain	VB
cord-262445-54ng7m92	243	19	a	a	DT
cord-262445-54ng7m92	243	20	reliable	reliable	JJ
cord-262445-54ng7m92	243	21	and	and	CC
cord-262445-54ng7m92	243	22	predictive	predictive	JJ
cord-262445-54ng7m92	243	23	in	in	FW
cord-262445-54ng7m92	243	24	vitro	vitro	FW
cord-262445-54ng7m92	243	25	human	human	JJ
cord-262445-54ng7m92	243	26	model	model	NN
cord-262445-54ng7m92	243	27	of	of	IN
cord-262445-54ng7m92	243	28	NMJ	NMJ	NNP
cord-262445-54ng7m92	243	29	in	in	IN
cord-262445-54ng7m92	243	30	physiological	physiological	JJ
cord-262445-54ng7m92	243	31	and	and	CC
cord-262445-54ng7m92	243	32	pathological	pathological	JJ
cord-262445-54ng7m92	243	33	conditions	condition	NNS
cord-262445-54ng7m92	243	34	,	,	,
cord-262445-54ng7m92	243	35	to	to	TO
cord-262445-54ng7m92	243	36	investigate	investigate	VB
cord-262445-54ng7m92	243	37	the	the	DT
cord-262445-54ng7m92	243	38	occurrence	occurrence	NN
cord-262445-54ng7m92	243	39	of	of	IN
cord-262445-54ng7m92	243	40	synapse	synapse	NN
cord-262445-54ng7m92	243	41	detriment	detriment	NN
cord-262445-54ng7m92	243	42	in	in	IN
cord-262445-54ng7m92	243	43	neuromuscular	neuromuscular	JJ
cord-262445-54ng7m92	243	44	diseases	disease	NNS
cord-262445-54ng7m92	243	45	.	.	.
cord-262445-54ng7m92	244	1	For	for	IN
cord-262445-54ng7m92	244	2	this	this	DT
cord-262445-54ng7m92	244	3	purpose	purpose	NN
cord-262445-54ng7m92	244	4	,	,	,
cord-262445-54ng7m92	244	5	motor	motor	NN
cord-262445-54ng7m92	244	6	neurons	neuron	NNS
cord-262445-54ng7m92	244	7	derived	derive	VBN
cord-262445-54ng7m92	244	8	from	from	IN
cord-262445-54ng7m92	244	9	human	human	NN
cord-262445-54ng7m92	244	10	iPSCs	ipscs	CD
cord-262445-54ng7m92	244	11	and	and	CC
cord-262445-54ng7m92	244	12	human	human	JJ
cord-262445-54ng7m92	244	13	skeletal	skeletal	JJ
cord-262445-54ng7m92	244	14	muscle	muscle	NN
cord-262445-54ng7m92	244	15	cells	cell	NNS
cord-262445-54ng7m92	244	16	derived	derive	VBN
cord-262445-54ng7m92	244	17	from	from	IN
cord-262445-54ng7m92	244	18	either	either	DT
cord-262445-54ng7m92	244	19	perivascular	perivascular	JJ
cord-262445-54ng7m92	244	20	muscle	muscle	NN
cord-262445-54ng7m92	244	21	progenitors	progenitor	NNS
cord-262445-54ng7m92	244	22	,	,	,
cord-262445-54ng7m92	244	23	namely	namely	RB
cord-262445-54ng7m92	244	24	Pericytes	Pericytes	NNPS
cord-262445-54ng7m92	244	25	,	,	,
cord-262445-54ng7m92	244	26	or	or	CC
cord-262445-54ng7m92	244	27	immortalized	immortalize	VBN
cord-262445-54ng7m92	244	28	myoblasts	myoblast	NNS
cord-262445-54ng7m92	244	29	are	be	VBP
cord-262445-54ng7m92	244	30	seeded	seed	VBN
cord-262445-54ng7m92	244	31	in	in	IN
cord-262445-54ng7m92	244	32	two	two	CD
cord-262445-54ng7m92	244	33	separated	separated	JJ
cord-262445-54ng7m92	244	34	chambers	chamber	NNS
cord-262445-54ng7m92	244	35	of	of	IN
cord-262445-54ng7m92	244	36	a	a	DT
cord-262445-54ng7m92	244	37	microfluidic	microfluidic	JJ
cord-262445-54ng7m92	244	38	device	device	NN
cord-262445-54ng7m92	244	39	.	.	.
cord-262445-54ng7m92	245	1	The	the	DT
cord-262445-54ng7m92	245	2	two	two	CD
cord-262445-54ng7m92	245	3	side	side	NN
cord-262445-54ng7m92	245	4	of	of	IN
cord-262445-54ng7m92	245	5	the	the	DT
cord-262445-54ng7m92	245	6	device	device	NN
cord-262445-54ng7m92	245	7	are	be	VBP
cord-262445-54ng7m92	245	8	linked	link	VBN
cord-262445-54ng7m92	245	9	together	together	RB
cord-262445-54ng7m92	245	10	through	through	IN
cord-262445-54ng7m92	245	11	microchannels	microchannel	NNS
cord-262445-54ng7m92	245	12	that	that	WDT
cord-262445-54ng7m92	245	13	enable	enable	VBP
cord-262445-54ng7m92	245	14	the	the	DT
cord-262445-54ng7m92	245	15	axonal	axonal	JJ
cord-262445-54ng7m92	245	16	outgrowth	outgrowth	NN
cord-262445-54ng7m92	245	17	to	to	IN
cord-262445-54ng7m92	245	18	the	the	DT
cord-262445-54ng7m92	245	19	muscle	muscle	NN
cord-262445-54ng7m92	245	20	side	side	NN
cord-262445-54ng7m92	245	21	,	,	,
cord-262445-54ng7m92	245	22	but	but	CC
cord-262445-54ng7m92	245	23	not	not	RB
cord-262445-54ng7m92	245	24	cell	cell	NN
cord-262445-54ng7m92	245	25	bodies	body	NNS
cord-262445-54ng7m92	245	26	migration	migration	NN
cord-262445-54ng7m92	245	27	,	,	,
cord-262445-54ng7m92	245	28	allowing	allow	VBG
cord-262445-54ng7m92	245	29	the	the	DT
cord-262445-54ng7m92	245	30	compartmentalization	compartmentalization	NN
cord-262445-54ng7m92	245	31	of	of	IN
cord-262445-54ng7m92	245	32	the	the	DT
cord-262445-54ng7m92	245	33	cell	cell	NN
cord-262445-54ng7m92	245	34	populations	population	NNS
cord-262445-54ng7m92	245	35	without	without	IN
cord-262445-54ng7m92	245	36	interrupting	interrupt	VBG
cord-262445-54ng7m92	245	37	cell	cell	NN
cord-262445-54ng7m92	245	38	-	-	HYPH
cord-262445-54ng7m92	245	39	cell	cell	NN
cord-262445-54ng7m92	245	40	communication	communication	NN
cord-262445-54ng7m92	245	41	.	.	.
cord-262445-54ng7m92	246	1	While	while	IN
cord-262445-54ng7m92	246	2	being	be	VBG
cord-262445-54ng7m92	246	3	designed	design	VBN
cord-262445-54ng7m92	246	4	as	as	IN
cord-262445-54ng7m92	246	5	a	a	DT
cord-262445-54ng7m92	246	6	reliable	reliable	JJ
cord-262445-54ng7m92	246	7	platform	platform	NN
cord-262445-54ng7m92	246	8	to	to	TO
cord-262445-54ng7m92	246	9	investigate	investigate	VB
cord-262445-54ng7m92	246	10	the	the	DT
cord-262445-54ng7m92	246	11	molecular	molecular	JJ
cord-262445-54ng7m92	246	12	actors	actor	NNS
cord-262445-54ng7m92	246	13	of	of	IN
cord-262445-54ng7m92	246	14	NMJ	NMJ	NNP
cord-262445-54ng7m92	246	15	processes	process	NNS
cord-262445-54ng7m92	246	16	,	,	,
cord-262445-54ng7m92	246	17	the	the	DT
cord-262445-54ng7m92	246	18	setup	setup	NN
cord-262445-54ng7m92	246	19	is	be	VBZ
cord-262445-54ng7m92	246	20	versatile	versatile	JJ
cord-262445-54ng7m92	246	21	enough	enough	RB
cord-262445-54ng7m92	246	22	to	to	TO
cord-262445-54ng7m92	246	23	host	host	VB
cord-262445-54ng7m92	246	24	patient	patient	JJ
cord-262445-54ng7m92	246	25	-	-	HYPH
cord-262445-54ng7m92	246	26	specific	specific	JJ
cord-262445-54ng7m92	246	27	cells	cell	NNS
cord-262445-54ng7m92	246	28	and	and	CC
cord-262445-54ng7m92	246	29	perform	perform	VB
cord-262445-54ng7m92	246	30	functional	functional	JJ
cord-262445-54ng7m92	246	31	and	and	CC
cord-262445-54ng7m92	246	32	molecular	molecular	JJ
cord-262445-54ng7m92	246	33	analysis	analysis	NN
cord-262445-54ng7m92	246	34	.	.	.
cord-262445-54ng7m92	247	1	Spinal	spinal	JJ
cord-262445-54ng7m92	247	2	and	and	CC
cord-262445-54ng7m92	247	3	bulbar	bulbar	JJ
cord-262445-54ng7m92	247	4	muscular	muscular	JJ
cord-262445-54ng7m92	247	5	atrophy	atrophy	NN
cord-262445-54ng7m92	247	6	(	(	-LRB-
cord-262445-54ng7m92	247	7	SBMA	SBMA	NNP
cord-262445-54ng7m92	247	8	)	)	-RRB-
cord-262445-54ng7m92	247	9	is	be	VBZ
cord-262445-54ng7m92	247	10	caused	cause	VBN
cord-262445-54ng7m92	247	11	by	by	IN
cord-262445-54ng7m92	247	12	polyglutamine	polyglutamine	NNP
cord-262445-54ng7m92	247	13	(	(	-LRB-
cord-262445-54ng7m92	247	14	polyQ	polyQ	NNP
cord-262445-54ng7m92	247	15	)	)	-RRB-
cord-262445-54ng7m92	247	16	expansions	expansion	NNS
cord-262445-54ng7m92	247	17	in	in	IN
cord-262445-54ng7m92	247	18	the	the	DT
cord-262445-54ng7m92	247	19	AR	AR	NNP
cord-262445-54ng7m92	247	20	gene	gene	NN
cord-262445-54ng7m92	247	21	.	.	.
cord-262445-54ng7m92	248	1	Although	although	IN
cord-262445-54ng7m92	248	2	clinical	clinical	JJ
cord-262445-54ng7m92	248	3	and	and	CC
cord-262445-54ng7m92	248	4	experimental	experimental	JJ
cord-262445-54ng7m92	248	5	evidence	evidence	NN
cord-262445-54ng7m92	248	6	highlight	highlight	VBP
cord-262445-54ng7m92	248	7	a	a	DT
cord-262445-54ng7m92	248	8	primary	primary	JJ
cord-262445-54ng7m92	248	9	role	role	NN
cord-262445-54ng7m92	248	10	for	for	IN
cord-262445-54ng7m92	248	11	skeletal	skeletal	JJ
cord-262445-54ng7m92	248	12	muscle	muscle	NN
cord-262445-54ng7m92	248	13	in	in	IN
cord-262445-54ng7m92	248	14	the	the	DT
cord-262445-54ng7m92	248	15	onset	onset	NN
cord-262445-54ng7m92	248	16	,	,	,
cord-262445-54ng7m92	248	17	progression	progression	NN
cord-262445-54ng7m92	248	18	,	,	,
cord-262445-54ng7m92	248	19	and	and	CC
cord-262445-54ng7m92	248	20	outcome	outcome	NN
cord-262445-54ng7m92	248	21	of	of	IN
cord-262445-54ng7m92	248	22	SBMA	SBMA	NNP
cord-262445-54ng7m92	248	23	,	,	,
cord-262445-54ng7m92	248	24	the	the	DT
cord-262445-54ng7m92	248	25	pathophysiological	pathophysiological	JJ
cord-262445-54ng7m92	248	26	and	and	CC
cord-262445-54ng7m92	248	27	molecular	molecular	JJ
cord-262445-54ng7m92	248	28	processes	process	NNS
cord-262445-54ng7m92	249	1	underlying	underlie	VBG
cord-262445-54ng7m92	249	2	SBMA	SBMA	NNP
cord-262445-54ng7m92	249	3	muscle	muscle	NN
cord-262445-54ng7m92	249	4	atrophy	atrophy	NN
cord-262445-54ng7m92	249	5	are	be	VBP
cord-262445-54ng7m92	249	6	poorly	poorly	RB
cord-262445-54ng7m92	249	7	understood	understand	VBN
cord-262445-54ng7m92	249	8	.	.	.
cord-262445-54ng7m92	250	1	We	-PRON-	PRP
cord-262445-54ng7m92	250	2	show	show	VBP
cord-262445-54ng7m92	250	3	that	that	IN
cord-262445-54ng7m92	250	4	polyQ	polyQ	NNP
cord-262445-54ng7m92	250	5	-	-	HYPH
cord-262445-54ng7m92	250	6	expanded	expand	VBN
cord-262445-54ng7m92	250	7	AR	AR	NNP
cord-262445-54ng7m92	250	8	alters	alter	VBZ
cord-262445-54ng7m92	250	9	intrinsic	intrinsic	JJ
cord-262445-54ng7m92	250	10	muscle	muscle	NN
cord-262445-54ng7m92	250	11	force	force	NN
cord-262445-54ng7m92	250	12	generation	generation	NN
cord-262445-54ng7m92	250	13	before	before	IN
cord-262445-54ng7m92	250	14	denervation	denervation	NN
cord-262445-54ng7m92	250	15	.	.	.
cord-262445-54ng7m92	251	1	Reduced	reduce	VBN
cord-262445-54ng7m92	251	2	muscle	muscle	NN
cord-262445-54ng7m92	251	3	force	force	NN
cord-262445-54ng7m92	251	4	was	be	VBD
cord-262445-54ng7m92	251	5	associated	associate	VBN
cord-262445-54ng7m92	251	6	with	with	IN
cord-262445-54ng7m92	251	7	a	a	DT
cord-262445-54ng7m92	251	8	switch	switch	NN
cord-262445-54ng7m92	251	9	in	in	IN
cord-262445-54ng7m92	251	10	fiber	fiber	NN
cord-262445-54ng7m92	251	11	-	-	HYPH
cord-262445-54ng7m92	251	12	type	type	NN
cord-262445-54ng7m92	251	13	composition	composition	NN
cord-262445-54ng7m92	251	14	,	,	,
cord-262445-54ng7m92	251	15	disrupted	disrupt	VBD
cord-262445-54ng7m92	251	16	muscle	muscle	NN
cord-262445-54ng7m92	251	17	striation	striation	NN
cord-262445-54ng7m92	251	18	,	,	,
cord-262445-54ng7m92	251	19	altered	alter	VBN
cord-262445-54ng7m92	251	20	calcium	calcium	NN
cord-262445-54ng7m92	251	21	(	(	-LRB-
cord-262445-54ng7m92	251	22	Ca++	Ca++	NNP
cord-262445-54ng7m92	251	23	)	)	-RRB-
cord-262445-54ng7m92	251	24	dynamics	dynamic	NNS
cord-262445-54ng7m92	251	25	in	in	IN
cord-262445-54ng7m92	251	26	response	response	NN
cord-262445-54ng7m92	251	27	to	to	IN
cord-262445-54ng7m92	251	28	muscle	muscle	NN
cord-262445-54ng7m92	251	29	contraction	contraction	NN
cord-262445-54ng7m92	251	30	,	,	,
cord-262445-54ng7m92	251	31	and	and	CC
cord-262445-54ng7m92	251	32	aberrant	aberrant	JJ
cord-262445-54ng7m92	251	33	expression	expression	NN
cord-262445-54ng7m92	251	34	of	of	IN
cord-262445-54ng7m92	251	35	excitation	excitation	NN
cord-262445-54ng7m92	251	36	-	-	HYPH
cord-262445-54ng7m92	251	37	contraction	contraction	NN
cord-262445-54ng7m92	251	38	coupling	coupling	NN
cord-262445-54ng7m92	251	39	(	(	-LRB-
cord-262445-54ng7m92	251	40	ECC	ECC	NNP
cord-262445-54ng7m92	251	41	)	)	-RRB-
cord-262445-54ng7m92	251	42	machinery	machinery	NN
cord-262445-54ng7m92	251	43	genes	gene	NNS
cord-262445-54ng7m92	251	44	in	in	IN
cord-262445-54ng7m92	251	45	transgenic	transgenic	JJ
cord-262445-54ng7m92	251	46	,	,	,
cord-262445-54ng7m92	251	47	knock	knock	NN
cord-262445-54ng7m92	251	48	-	-	HYPH
cord-262445-54ng7m92	251	49	in	in	NN
cord-262445-54ng7m92	251	50	and	and	CC
cord-262445-54ng7m92	251	51	inducible	inducible	JJ
cord-262445-54ng7m92	251	52	SBMA	SBMA	NNP
cord-262445-54ng7m92	251	53	mice	mouse	NNS
cord-262445-54ng7m92	251	54	and	and	CC
cord-262445-54ng7m92	251	55	patients	patient	NNS
cord-262445-54ng7m92	251	56	.	.	.
cord-262445-54ng7m92	252	1	Acute	acute	JJ
cord-262445-54ng7m92	252	2	suppression	suppression	NN
cord-262445-54ng7m92	252	3	of	of	IN
cord-262445-54ng7m92	252	4	AR	AR	NNP
cord-262445-54ng7m92	252	5	activation	activation	NN
cord-262445-54ng7m92	252	6	by	by	IN
cord-262445-54ng7m92	252	7	surgical	surgical	JJ
cord-262445-54ng7m92	252	8	castration	castration	NN
cord-262445-54ng7m92	252	9	elicited	elicit	VBD
cord-262445-54ng7m92	252	10	similar	similar	JJ
cord-262445-54ng7m92	252	11	ECC	ECC	NNP
cord-262445-54ng7m92	252	12	gene	gene	NN
cord-262445-54ng7m92	252	13	expression	expression	NN
cord-262445-54ng7m92	252	14	changes	change	NNS
cord-262445-54ng7m92	252	15	in	in	IN
cord-262445-54ng7m92	252	16	normal	normal	JJ
cord-262445-54ng7m92	252	17	mice	mouse	NNS
cord-262445-54ng7m92	252	18	,	,	,
cord-262445-54ng7m92	252	19	suggesting	suggest	VBG
cord-262445-54ng7m92	252	20	that	that	IN
cord-262445-54ng7m92	252	21	AR	AR	NNP
cord-262445-54ng7m92	252	22	regulates	regulate	VBZ
cord-262445-54ng7m92	252	23	the	the	DT
cord-262445-54ng7m92	252	24	expression	expression	NN
cord-262445-54ng7m92	252	25	of	of	IN
cord-262445-54ng7m92	252	26	these	these	DT
cord-262445-54ng7m92	252	27	genes	gene	NNS
cord-262445-54ng7m92	252	28	in	in	IN
cord-262445-54ng7m92	252	29	physiological	physiological	JJ
cord-262445-54ng7m92	252	30	conditions	condition	NNS
cord-262445-54ng7m92	252	31	.	.	.
cord-262445-54ng7m92	253	1	Importantly	importantly	RB
cord-262445-54ng7m92	253	2	,	,	,
cord-262445-54ng7m92	253	3	treatment	treatment	NN
cord-262445-54ng7m92	253	4	to	to	TO
cord-262445-54ng7m92	253	5	suppress	suppress	VB
cord-262445-54ng7m92	253	6	polyQ	polyQ	NNP
cord-262445-54ng7m92	253	7	-	-	HYPH
cord-262445-54ng7m92	253	8	expanded	expand	VBN
cord-262445-54ng7m92	253	9	AR	AR	NNP
cord-262445-54ng7m92	253	10	expression	expression	NN
cord-262445-54ng7m92	253	11	restored	restore	VBD
cord-262445-54ng7m92	253	12	ECC	ECC	NNP
cord-262445-54ng7m92	253	13	gene	gene	NN
cord-262445-54ng7m92	253	14	expression	expression	NN
cord-262445-54ng7m92	253	15	back	back	RB
cord-262445-54ng7m92	253	16	to	to	IN
cord-262445-54ng7m92	253	17	normal	normal	JJ
cord-262445-54ng7m92	253	18	.	.	.
cord-262445-54ng7m92	254	1	Bioinformatic	bioinformatic	JJ
cord-262445-54ng7m92	254	2	analysis	analysis	NN
cord-262445-54ng7m92	254	3	revealed	reveal	VBD
cord-262445-54ng7m92	254	4	the	the	DT
cord-262445-54ng7m92	254	5	presence	presence	NN
cord-262445-54ng7m92	254	6	of	of	IN
cord-262445-54ng7m92	254	7	androgen	androgen	NN
cord-262445-54ng7m92	254	8	-	-	HYPH
cord-262445-54ng7m92	254	9	responsive	responsive	JJ
cord-262445-54ng7m92	254	10	elements	element	NNS
cord-262445-54ng7m92	254	11	on	on	IN
cord-262445-54ng7m92	254	12	several	several	JJ
cord-262445-54ng7m92	254	13	genes	gene	NNS
cord-262445-54ng7m92	254	14	involved	involve	VBN
cord-262445-54ng7m92	254	15	in	in	IN
cord-262445-54ng7m92	254	16	muscle	muscle	NN
cord-262445-54ng7m92	254	17	function	function	NN
cord-262445-54ng7m92	254	18	and	and	CC
cord-262445-54ng7m92	254	19	homeostasis	homeostasis	NN
cord-262445-54ng7m92	254	20	.	.	.
cord-262445-54ng7m92	255	1	Experimental	experimental	JJ
cord-262445-54ng7m92	255	2	evidence	evidence	NN
cord-262445-54ng7m92	255	3	showed	show	VBD
cord-262445-54ng7m92	255	4	ARdependent	ardependent	JJ
cord-262445-54ng7m92	255	5	regulation	regulation	NN
cord-262445-54ng7m92	255	6	of	of	IN
cord-262445-54ng7m92	255	7	expression	expression	NN
cord-262445-54ng7m92	255	8	and	and	CC
cord-262445-54ng7m92	255	9	promoter	promoter	NN
cord-262445-54ng7m92	255	10	occupancy	occupancy	NN
cord-262445-54ng7m92	255	11	of	of	IN
cord-262445-54ng7m92	255	12	the	the	DT
cord-262445-54ng7m92	255	13	most	most	RBS
cord-262445-54ng7m92	255	14	up	up	RB
cord-262445-54ng7m92	255	15	-	-	HYPH
cord-262445-54ng7m92	255	16	regulated	regulate	VBN
cord-262445-54ng7m92	255	17	gene	gene	NN
cord-262445-54ng7m92	255	18	from	from	IN
cord-262445-54ng7m92	255	19	transcriptomic	transcriptomic	NNP
cord-262445-54ng7m92	255	20	analysis	analysis	NN
cord-262445-54ng7m92	255	21	in	in	IN
cord-262445-54ng7m92	255	22	SBMA	SBMA	NNP
cord-262445-54ng7m92	255	23	muscle	muscle	NN
cord-262445-54ng7m92	255	24	.	.	.
cord-262445-54ng7m92	256	1	These	these	DT
cord-262445-54ng7m92	256	2	observations	observation	NNS
cord-262445-54ng7m92	256	3	reveal	reveal	VBP
cord-262445-54ng7m92	256	4	an	an	DT
cord-262445-54ng7m92	256	5	unpredicted	unpredicted	JJ
cord-262445-54ng7m92	256	6	role	role	NN
cord-262445-54ng7m92	256	7	for	for	IN
cord-262445-54ng7m92	256	8	AR	AR	NNP
cord-262445-54ng7m92	256	9	in	in	IN
cord-262445-54ng7m92	256	10	the	the	DT
cord-262445-54ng7m92	256	11	regulation	regulation	NN
cord-262445-54ng7m92	256	12	of	of	IN
cord-262445-54ng7m92	256	13	expression	expression	NN
cord-262445-54ng7m92	256	14	of	of	IN
cord-262445-54ng7m92	256	15	genes	gene	NNS
cord-262445-54ng7m92	256	16	involved	involve	VBN
cord-262445-54ng7m92	256	17	in	in	IN
cord-262445-54ng7m92	256	18	muscle	muscle	NN
cord-262445-54ng7m92	256	19	contraction	contraction	NN
cord-262445-54ng7m92	256	20	and	and	CC
cord-262445-54ng7m92	256	21	Ca++	Ca++	NNP
cord-262445-54ng7m92	256	22	dynamics	dynamic	NNS
cord-262445-54ng7m92	256	23	,	,	,
cord-262445-54ng7m92	256	24	a	a	DT
cord-262445-54ng7m92	256	25	level	level	NN
cord-262445-54ng7m92	256	26	of	of	IN
cord-262445-54ng7m92	256	27	muscle	muscle	NN
cord-262445-54ng7m92	256	28	function	function	NN
cord-262445-54ng7m92	256	29	regulation	regulation	NN
cord-262445-54ng7m92	256	30	that	that	WDT
cord-262445-54ng7m92	256	31	is	be	VBZ
cord-262445-54ng7m92	256	32	disrupted	disrupt	VBN
cord-262445-54ng7m92	256	33	in	in	IN
cord-262445-54ng7m92	256	34	SBMA	SBMA	NNP
cord-262445-54ng7m92	256	35	muscle	muscle	NN
cord-262445-54ng7m92	256	36	,	,	,
cord-262445-54ng7m92	256	37	yet	yet	CC
cord-262445-54ng7m92	256	38	restored	restore	VBN
cord-262445-54ng7m92	256	39	by	by	IN
cord-262445-54ng7m92	256	40	pharmacologic	pharmacologic	JJ
cord-262445-54ng7m92	256	41	treatment	treatment	NN
cord-262445-54ng7m92	256	42	.	.	.
cord-262445-54ng7m92	257	1	The	the	DT
cord-262445-54ng7m92	257	2	aim	aim	NN
cord-262445-54ng7m92	257	3	of	of	IN
cord-262445-54ng7m92	257	4	this	this	DT
cord-262445-54ng7m92	257	5	project	project	NN
cord-262445-54ng7m92	257	6	is	be	VBZ
cord-262445-54ng7m92	257	7	to	to	TO
cord-262445-54ng7m92	257	8	dissect	dissect	VB
cord-262445-54ng7m92	257	9	the	the	DT
cord-262445-54ng7m92	257	10	identity	identity	NN
cord-262445-54ng7m92	257	11	and	and	CC
cord-262445-54ng7m92	257	12	localization	localization	NN
cord-262445-54ng7m92	257	13	of	of	IN
cord-262445-54ng7m92	257	14	the	the	DT
cord-262445-54ng7m92	257	15	nascent	nascent	JJ
cord-262445-54ng7m92	257	16	muscle	muscle	NN
cord-262445-54ng7m92	257	17	proteome	proteome	NN
cord-262445-54ng7m92	257	18	in	in	IN
cord-262445-54ng7m92	257	19	vivo	vivo	NNP
cord-262445-54ng7m92	257	20	.	.	.
cord-262445-54ng7m92	258	1	The	the	DT
cord-262445-54ng7m92	258	2	tool	tool	NN
cord-262445-54ng7m92	258	3	of	of	IN
cord-262445-54ng7m92	258	4	choice	choice	NN
cord-262445-54ng7m92	258	5	is	be	VBZ
cord-262445-54ng7m92	258	6	the	the	DT
cord-262445-54ng7m92	258	7	transgenic	transgenic	JJ
cord-262445-54ng7m92	258	8	mouse	mouse	NN
cord-262445-54ng7m92	258	9	MetRS	MetRS	NNP
cord-262445-54ng7m92	258	10	,	,	,
cord-262445-54ng7m92	258	11	expressing	express	VBG
cord-262445-54ng7m92	258	12	a	a	DT
cord-262445-54ng7m92	258	13	mutant	mutant	JJ
cord-262445-54ng7m92	258	14	methionyl	methionyl	NN
cord-262445-54ng7m92	258	15	-	-	HYPH
cord-262445-54ng7m92	258	16	tRNA	trna	NN
cord-262445-54ng7m92	258	17	synthetase	synthetase	NN
cord-262445-54ng7m92	258	18	together	together	RB
cord-262445-54ng7m92	258	19	with	with	IN
cord-262445-54ng7m92	258	20	a	a	DT
cord-262445-54ng7m92	258	21	green	green	JJ
cord-262445-54ng7m92	258	22	fluorescent	fluorescent	NN
cord-262445-54ng7m92	258	23	protein	protein	NN
cord-262445-54ng7m92	258	24	.	.	.
cord-262445-54ng7m92	259	1	We	-PRON-	PRP
cord-262445-54ng7m92	259	2	crossed	cross	VBD
cord-262445-54ng7m92	259	3	this	this	DT
cord-262445-54ng7m92	259	4	mouse	mouse	NN
cord-262445-54ng7m92	259	5	with	with	IN
cord-262445-54ng7m92	259	6	a	a	DT
cord-262445-54ng7m92	259	7	skeletal	skeletal	JJ
cord-262445-54ng7m92	259	8	muscle	muscle	NN
cord-262445-54ng7m92	259	9	specific	specific	JJ
cord-262445-54ng7m92	259	10	CRE	CRE	NNP
cord-262445-54ng7m92	259	11	-	-	HYPH
cord-262445-54ng7m92	259	12	expressing	express	VBG
cord-262445-54ng7m92	259	13	mouse	mouse	NN
cord-262445-54ng7m92	259	14	to	to	TO
cord-262445-54ng7m92	259	15	obtain	obtain	VB
cord-262445-54ng7m92	259	16	a	a	DT
cord-262445-54ng7m92	259	17	tissue	tissue	NN
cord-262445-54ng7m92	259	18	specific	specific	JJ
cord-262445-54ng7m92	259	19	expression	expression	NN
cord-262445-54ng7m92	259	20	.	.	.
cord-262445-54ng7m92	260	1	The	the	DT
cord-262445-54ng7m92	260	2	mutated	mutated	JJ
cord-262445-54ng7m92	260	3	methionyl	methionyl	NN
cord-262445-54ng7m92	260	4	-	-	HYPH
cord-262445-54ng7m92	260	5	tRNA	trna	NN
cord-262445-54ng7m92	260	6	synthetase	synthetase	NN
cord-262445-54ng7m92	260	7	can	can	MD
cord-262445-54ng7m92	260	8	integrate	integrate	VB
cord-262445-54ng7m92	260	9	a	a	DT
cord-262445-54ng7m92	260	10	synthetic	synthetic	JJ
cord-262445-54ng7m92	260	11	amino	amino	NN
cord-262445-54ng7m92	260	12	acid	acid	NN
cord-262445-54ng7m92	260	13	(	(	-LRB-
cord-262445-54ng7m92	260	14	ANL	ANL	NNP
cord-262445-54ng7m92	260	15	)	)	-RRB-
cord-262445-54ng7m92	260	16	instead	instead	RB
cord-262445-54ng7m92	260	17	of	of	IN
cord-262445-54ng7m92	260	18	a	a	DT
cord-262445-54ng7m92	260	19	methionine	methionine	NN
cord-262445-54ng7m92	260	20	in	in	IN
cord-262445-54ng7m92	260	21	a	a	DT
cord-262445-54ng7m92	260	22	nascent	nascent	JJ
cord-262445-54ng7m92	260	23	peptide	peptide	NN
cord-262445-54ng7m92	260	24	chain	chain	NN
cord-262445-54ng7m92	260	25	.	.	.
cord-262445-54ng7m92	261	1	The	the	DT
cord-262445-54ng7m92	261	2	synthetic	synthetic	JJ
cord-262445-54ng7m92	261	3	amino	amino	NN
cord-262445-54ng7m92	261	4	acid	acid	NN
cord-262445-54ng7m92	261	5	side	side	NN
cord-262445-54ng7m92	261	6	chain	chain	NN
cord-262445-54ng7m92	261	7	ends	end	VBZ
cord-262445-54ng7m92	261	8	with	with	IN
cord-262445-54ng7m92	261	9	an	an	DT
cord-262445-54ng7m92	261	10	azide	azide	NN
cord-262445-54ng7m92	261	11	,	,	,
cord-262445-54ng7m92	261	12	allowing	allow	VBG
cord-262445-54ng7m92	261	13	the	the	DT
cord-262445-54ng7m92	261	14	formation	formation	NN
cord-262445-54ng7m92	261	15	of	of	IN
cord-262445-54ng7m92	261	16	a	a	DT
cord-262445-54ng7m92	261	17	covalent	covalent	JJ
cord-262445-54ng7m92	261	18	bond	bond	NN
cord-262445-54ng7m92	261	19	with	with	IN
cord-262445-54ng7m92	261	20	an	an	DT
cord-262445-54ng7m92	261	21	alkyne	alkyne	NN
cord-262445-54ng7m92	261	22	by	by	IN
cord-262445-54ng7m92	261	23	a	a	DT
cord-262445-54ng7m92	261	24	click	click	NN
cord-262445-54ng7m92	261	25	chemistry	chemistry	NN
cord-262445-54ng7m92	261	26	reaction	reaction	NN
cord-262445-54ng7m92	261	27	.	.	.
cord-262445-54ng7m92	262	1	To	to	TO
cord-262445-54ng7m92	262	2	visualize	visualize	VB
cord-262445-54ng7m92	262	3	the	the	DT
cord-262445-54ng7m92	262	4	GFP-2A	GFP-2A	NNP
cord-262445-54ng7m92	262	5	-	-	HYPH
cord-262445-54ng7m92	262	6	MetRS	MetRS	NNP
cord-262445-54ng7m92	262	7	expression	expression	NN
cord-262445-54ng7m92	262	8	,	,	,
cord-262445-54ng7m92	262	9	a	a	DT
cord-262445-54ng7m92	262	10	western	western	JJ
cord-262445-54ng7m92	262	11	-	-	HYPH
cord-262445-54ng7m92	262	12	blot	blot	NN
cord-262445-54ng7m92	262	13	with	with	IN
cord-262445-54ng7m92	262	14	anti	anti	JJ
cord-262445-54ng7m92	262	15	GFP	GFP	NNP
cord-262445-54ng7m92	262	16	antibody	antibody	NN
cord-262445-54ng7m92	262	17	has	have	VBZ
cord-262445-54ng7m92	262	18	been	be	VBN
cord-262445-54ng7m92	262	19	performed	perform	VBN
cord-262445-54ng7m92	262	20	as	as	RB
cord-262445-54ng7m92	262	21	well	well	RB
cord-262445-54ng7m92	262	22	as	as	IN
cord-262445-54ng7m92	262	23	immunohistochemistry	immunohistochemistry	NN
cord-262445-54ng7m92	262	24	on	on	IN
cord-262445-54ng7m92	262	25	cryosections	cryosection	NNS
cord-262445-54ng7m92	262	26	.	.	.
cord-262445-54ng7m92	263	1	The	the	DT
cord-262445-54ng7m92	263	2	flexibility	flexibility	NN
cord-262445-54ng7m92	263	3	of	of	IN
cord-262445-54ng7m92	263	4	the	the	DT
cord-262445-54ng7m92	263	5	click	click	NN
cord-262445-54ng7m92	263	6	reaction	reaction	NN
cord-262445-54ng7m92	263	7	allows	allow	VBZ
cord-262445-54ng7m92	263	8	the	the	DT
cord-262445-54ng7m92	263	9	visualization	visualization	NN
cord-262445-54ng7m92	263	10	of	of	IN
cord-262445-54ng7m92	263	11	nascent	nascent	JJ
cord-262445-54ng7m92	263	12	peptide	peptide	NN
cord-262445-54ng7m92	263	13	chains	chain	NNS
cord-262445-54ng7m92	263	14	either	either	CC
cord-262445-54ng7m92	263	15	by	by	IN
cord-262445-54ng7m92	263	16	western	western	JJ
cord-262445-54ng7m92	263	17	blot	blot	NN
cord-262445-54ng7m92	263	18	or	or	CC
cord-262445-54ng7m92	263	19	immunofluorescence	immunofluorescence	NN
cord-262445-54ng7m92	263	20	.	.	.
cord-262445-54ng7m92	264	1	Intraperitoneal	intraperitoneal	JJ
cord-262445-54ng7m92	264	2	injections	injection	NNS
cord-262445-54ng7m92	264	3	of	of	IN
cord-262445-54ng7m92	264	4	ANL	anl	NN
cord-262445-54ng7m92	264	5	for	for	IN
cord-262445-54ng7m92	264	6	different	different	JJ
cord-262445-54ng7m92	264	7	time	time	NN
cord-262445-54ng7m92	264	8	periods	period	NNS
cord-262445-54ng7m92	264	9	resulted	result	VBN
cord-262445-54ng7m92	264	10	in	in	IN
cord-262445-54ng7m92	264	11	a	a	DT
cord-262445-54ng7m92	264	12	significant	significant	JJ
cord-262445-54ng7m92	264	13	labelling	labelling	NN
cord-262445-54ng7m92	264	14	of	of	IN
cord-262445-54ng7m92	264	15	the	the	DT
cord-262445-54ng7m92	264	16	muscle	muscle	NN
cord-262445-54ng7m92	264	17	proteome	proteome	NN
cord-262445-54ng7m92	264	18	after	after	IN
cord-262445-54ng7m92	264	19	1	1	CD
cord-262445-54ng7m92	264	20	,	,	,
cord-262445-54ng7m92	264	21	2	2	CD
cord-262445-54ng7m92	264	22	and	and	CC
cord-262445-54ng7m92	264	23	7	7	CD
cord-262445-54ng7m92	264	24	days	day	NNS
cord-262445-54ng7m92	264	25	.	.	.
cord-262445-54ng7m92	265	1	After	after	IN
cord-262445-54ng7m92	265	2	the	the	DT
cord-262445-54ng7m92	265	3	protein	protein	NN
cord-262445-54ng7m92	265	4	extraction	extraction	NN
cord-262445-54ng7m92	265	5	,	,	,
cord-262445-54ng7m92	265	6	each	each	DT
cord-262445-54ng7m92	265	7	whole	whole	JJ
cord-262445-54ng7m92	265	8	cell	cell	NN
cord-262445-54ng7m92	265	9	lysate	lysate	NN
cord-262445-54ng7m92	265	10	has	have	VBZ
cord-262445-54ng7m92	265	11	been	be	VBN
cord-262445-54ng7m92	265	12	clicked	click	VBN
cord-262445-54ng7m92	265	13	with	with	IN
cord-262445-54ng7m92	265	14	biotin	biotin	NN
cord-262445-54ng7m92	265	15	labelled	label	VBN
cord-262445-54ng7m92	265	16	alkyne	alkyne	NN
cord-262445-54ng7m92	265	17	in	in	IN
cord-262445-54ng7m92	265	18	the	the	DT
cord-262445-54ng7m92	265	19	presence	presence	NN
cord-262445-54ng7m92	265	20	of	of	IN
cord-262445-54ng7m92	265	21	copper	copper	NN
cord-262445-54ng7m92	265	22	(	(	-LRB-
cord-262445-54ng7m92	265	23	II	II	NNP
cord-262445-54ng7m92	265	24	)	)	-RRB-
cord-262445-54ng7m92	265	25	sulphate	sulphate	NN
cord-262445-54ng7m92	265	26	and	and	CC
cord-262445-54ng7m92	265	27	ascorbic	ascorbic	NN
cord-262445-54ng7m92	265	28	acid	acid	NN
cord-262445-54ng7m92	265	29	and	and	CC
cord-262445-54ng7m92	265	30	labelled	label	VBN
cord-262445-54ng7m92	265	31	proteins	protein	NNS
cord-262445-54ng7m92	265	32	were	be	VBD
cord-262445-54ng7m92	265	33	revealed	reveal	VBN
cord-262445-54ng7m92	265	34	by	by	IN
cord-262445-54ng7m92	265	35	western	western	JJ
cord-262445-54ng7m92	265	36	blotting	blotting	NN
cord-262445-54ng7m92	265	37	.	.	.
cord-262445-54ng7m92	266	1	Labelled	label	VBN
cord-262445-54ng7m92	266	2	proteins	protein	NNS
cord-262445-54ng7m92	266	3	can	can	MD
cord-262445-54ng7m92	266	4	also	also	RB
cord-262445-54ng7m92	266	5	be	be	VB
cord-262445-54ng7m92	266	6	revealed	reveal	VBN
cord-262445-54ng7m92	266	7	by	by	IN
cord-262445-54ng7m92	266	8	IHC	IHC	NNP
cord-262445-54ng7m92	266	9	performing	perform	VBG
cord-262445-54ng7m92	266	10	FUNCAT	FUNCAT	NNP
cord-262445-54ng7m92	266	11	(	(	-LRB-
cord-262445-54ng7m92	266	12	Fluorescent	fluorescent	JJ
cord-262445-54ng7m92	266	13	non	non	JJ
cord-262445-54ng7m92	266	14	-	-	JJ
cord-262445-54ng7m92	266	15	canonical	canonical	JJ
cord-262445-54ng7m92	266	16	amino	amino	NN
cord-262445-54ng7m92	266	17	-	-	HYPH
cord-262445-54ng7m92	266	18	acid	acid	NN
cord-262445-54ng7m92	266	19	tagging	tagging	NN
cord-262445-54ng7m92	266	20	)	)	-RRB-
cord-262445-54ng7m92	266	21	on	on	IN
cord-262445-54ng7m92	266	22	cryosections	cryosection	NNS
cord-262445-54ng7m92	266	23	.	.	.
cord-262445-54ng7m92	267	1	This	this	DT
cord-262445-54ng7m92	267	2	way	way	NN
cord-262445-54ng7m92	267	3	we	-PRON-	PRP
cord-262445-54ng7m92	267	4	were	be	VBD
cord-262445-54ng7m92	267	5	able	able	JJ
cord-262445-54ng7m92	267	6	to	to	TO
cord-262445-54ng7m92	267	7	identify	identify	VB
cord-262445-54ng7m92	267	8	that	that	IN
cord-262445-54ng7m92	267	9	a	a	DT
cord-262445-54ng7m92	267	10	specific	specific	JJ
cord-262445-54ng7m92	267	11	proteome	proteome	NN
cord-262445-54ng7m92	267	12	was	be	VBD
cord-262445-54ng7m92	267	13	synthesized	synthesize	VBN
cord-262445-54ng7m92	267	14	during	during	IN
cord-262445-54ng7m92	267	15	a	a	DT
cord-262445-54ng7m92	267	16	determined	determined	JJ
cord-262445-54ng7m92	267	17	amount	amount	NN
cord-262445-54ng7m92	267	18	of	of	IN
cord-262445-54ng7m92	267	19	time	time	NN
cord-262445-54ng7m92	267	20	.	.	.
cord-262445-54ng7m92	268	1	These	these	DT
cord-262445-54ng7m92	268	2	preliminary	preliminary	JJ
cord-262445-54ng7m92	268	3	studies	study	NNS
cord-262445-54ng7m92	268	4	will	will	MD
cord-262445-54ng7m92	268	5	give	give	VB
cord-262445-54ng7m92	268	6	us	-PRON-	PRP
cord-262445-54ng7m92	268	7	the	the	DT
cord-262445-54ng7m92	268	8	necessary	necessary	JJ
cord-262445-54ng7m92	268	9	tools	tool	NNS
cord-262445-54ng7m92	268	10	to	to	TO
cord-262445-54ng7m92	268	11	better	better	RB
cord-262445-54ng7m92	268	12	understand	understand	VB
cord-262445-54ng7m92	268	13	the	the	DT
cord-262445-54ng7m92	268	14	skeletal	skeletal	JJ
cord-262445-54ng7m92	268	15	muscle	muscle	NN
cord-262445-54ng7m92	268	16	proteome	proteome	NN
cord-262445-54ng7m92	268	17	in	in	IN
cord-262445-54ng7m92	268	18	physiological	physiological	JJ
cord-262445-54ng7m92	268	19	and	and	CC
cord-262445-54ng7m92	268	20	pathological	pathological	JJ
cord-262445-54ng7m92	268	21	conditions	condition	NNS
cord-262445-54ng7m92	268	22	.	.	.
cord-262445-54ng7m92	269	1	Mitochondria	mitochondrion	NNS
cord-262445-54ng7m92	269	2	change	change	VB
cord-262445-54ng7m92	269	3	distribution	distribution	NN
cord-262445-54ng7m92	269	4	across	across	IN
cord-262445-54ng7m92	269	5	cells	cell	NNS
cord-262445-54ng7m92	269	6	following	follow	VBG
cord-262445-54ng7m92	269	7	a	a	DT
cord-262445-54ng7m92	269	8	variety	variety	NN
cord-262445-54ng7m92	269	9	of	of	IN
cord-262445-54ng7m92	269	10	pathophysiological	pathophysiological	JJ
cord-262445-54ng7m92	269	11	stimuli	stimulus	NNS
cord-262445-54ng7m92	269	12	.	.	.
cord-262445-54ng7m92	270	1	The	the	DT
cord-262445-54ng7m92	270	2	mechanisms	mechanism	NNS
cord-262445-54ng7m92	270	3	presiding	preside	VBG
cord-262445-54ng7m92	270	4	over	over	IN
cord-262445-54ng7m92	270	5	this	this	DT
cord-262445-54ng7m92	270	6	redistribution	redistribution	NN
cord-262445-54ng7m92	270	7	are	be	VBP
cord-262445-54ng7m92	270	8	yet	yet	RB
cord-262445-54ng7m92	270	9	undefined	undefined	JJ
cord-262445-54ng7m92	270	10	.	.	.
cord-262445-54ng7m92	271	1	In	in	IN
cord-262445-54ng7m92	271	2	a	a	DT
cord-262445-54ng7m92	271	3	murine	murine	JJ
cord-262445-54ng7m92	271	4	model	model	NN
cord-262445-54ng7m92	271	5	overexpressing	overexpresse	VBG
cord-262445-54ng7m92	271	6	Drp1	Drp1	NNP
cord-262445-54ng7m92	271	7	specifically	specifically	RB
cord-262445-54ng7m92	271	8	in	in	IN
cord-262445-54ng7m92	271	9	skeletal	skeletal	JJ
cord-262445-54ng7m92	271	10	muscle	muscle	NN
cord-262445-54ng7m92	271	11	,	,	,
cord-262445-54ng7m92	271	12	we	-PRON-	PRP
cord-262445-54ng7m92	271	13	find	find	VBP
cord-262445-54ng7m92	271	14	marked	marked	JJ
cord-262445-54ng7m92	271	15	mitochondria	mitochondrion	NNS
cord-262445-54ng7m92	271	16	repositioning	reposition	VBG
cord-262445-54ng7m92	271	17	in	in	IN
cord-262445-54ng7m92	271	18	muscle	muscle	NN
cord-262445-54ng7m92	271	19	fibres	fibre	NNS
cord-262445-54ng7m92	271	20	and	and	CC
cord-262445-54ng7m92	271	21	we	-PRON-	PRP
cord-262445-54ng7m92	271	22	demonstrate	demonstrate	VBP
cord-262445-54ng7m92	271	23	that	that	IN
cord-262445-54ng7m92	271	24	Drp1	Drp1	NNP
cord-262445-54ng7m92	271	25	is	be	VBZ
cord-262445-54ng7m92	271	26	involved	involve	VBN
cord-262445-54ng7m92	271	27	in	in	IN
cord-262445-54ng7m92	271	28	this	this	DT
cord-262445-54ng7m92	271	29	process	process	NN
cord-262445-54ng7m92	271	30	.	.	.
cord-262445-54ng7m92	272	1	Drp1	Drp1	NNP
cord-262445-54ng7m92	272	2	binds	bind	VBZ
cord-262445-54ng7m92	272	3	KLC1	KLC1	NNP
cord-262445-54ng7m92	272	4	and	and	CC
cord-262445-54ng7m92	272	5	enhances	enhance	VBZ
cord-262445-54ng7m92	272	6	microtubule	microtubule	NN
cord-262445-54ng7m92	272	7	-	-	HYPH
cord-262445-54ng7m92	272	8	dependent	dependent	JJ
cord-262445-54ng7m92	272	9	transport	transport	NN
cord-262445-54ng7m92	272	10	of	of	IN
cord-262445-54ng7m92	272	11	mitochondria	mitochondrion	NNS
cord-262445-54ng7m92	272	12	.	.	.
cord-262445-54ng7m92	273	1	Drp1-KLC1	drp1-klc1	NN
cord-262445-54ng7m92	273	2	coupling	coupling	NN
cord-262445-54ng7m92	273	3	triggers	trigger	VBZ
cord-262445-54ng7m92	273	4	the	the	DT
cord-262445-54ng7m92	273	5	displacement	displacement	NN
cord-262445-54ng7m92	273	6	of	of	IN
cord-262445-54ng7m92	273	7	KIF5B	KIF5B	NNP
cord-262445-54ng7m92	273	8	from	from	IN
cord-262445-54ng7m92	273	9	kinesin-1	kinesin-1	NNP
cord-262445-54ng7m92	273	10	complex	complex	RB
cord-262445-54ng7m92	273	11	increasing	increase	VBG
cord-262445-54ng7m92	273	12	its	-PRON-	PRP$
cord-262445-54ng7m92	273	13	binding	binding	NN
cord-262445-54ng7m92	273	14	to	to	IN
cord-262445-54ng7m92	273	15	microtubule	microtubule	NN
cord-262445-54ng7m92	273	16	tracks	track	NNS
cord-262445-54ng7m92	273	17	and	and	CC
cord-262445-54ng7m92	273	18	mitochondrial	mitochondrial	JJ
cord-262445-54ng7m92	273	19	transport	transport	NN
cord-262445-54ng7m92	273	20	.	.	.
cord-262445-54ng7m92	274	1	High	high	JJ
cord-262445-54ng7m92	274	2	levels	level	NNS
cord-262445-54ng7m92	274	3	of	of	IN
cord-262445-54ng7m92	274	4	Drp1	Drp1	NNS
cord-262445-54ng7m92	274	5	exacerbate	exacerbate	VBP
cord-262445-54ng7m92	274	6	this	this	DT
cord-262445-54ng7m92	274	7	mechanism	mechanism	NN
cord-262445-54ng7m92	274	8	leading	lead	VBG
cord-262445-54ng7m92	274	9	to	to	IN
cord-262445-54ng7m92	274	10	the	the	DT
cord-262445-54ng7m92	274	11	repositioning	repositioning	NN
cord-262445-54ng7m92	274	12	of	of	IN
cord-262445-54ng7m92	274	13	mitochondria	mitochondrion	NNS
cord-262445-54ng7m92	274	14	closer	close	RBR
cord-262445-54ng7m92	274	15	to	to	IN
cord-262445-54ng7m92	274	16	nuclei	nucleus	NNS
cord-262445-54ng7m92	274	17	.	.	.
cord-262445-54ng7m92	275	1	The	the	DT
cord-262445-54ng7m92	275	2	reduction	reduction	NN
cord-262445-54ng7m92	275	3	of	of	IN
cord-262445-54ng7m92	275	4	Drp1	Drp1	NNP
cord-262445-54ng7m92	275	5	levels	level	NNS
cord-262445-54ng7m92	275	6	decreases	decrease	VBZ
cord-262445-54ng7m92	275	7	kinesin-1	kinesin-1	NNP
cord-262445-54ng7m92	275	8	activation	activation	NN
cord-262445-54ng7m92	275	9	and	and	CC
cord-262445-54ng7m92	275	10	induces	induce	VBZ
cord-262445-54ng7m92	275	11	the	the	DT
cord-262445-54ng7m92	275	12	partial	partial	JJ
cord-262445-54ng7m92	275	13	recovery	recovery	NN
cord-262445-54ng7m92	275	14	of	of	IN
cord-262445-54ng7m92	275	15	mitochondrial	mitochondrial	JJ
cord-262445-54ng7m92	275	16	distribution	distribution	NN
cord-262445-54ng7m92	275	17	,	,	,
cord-262445-54ng7m92	275	18	thus	thus	RB
cord-262445-54ng7m92	275	19	linking	link	VBG
cord-262445-54ng7m92	275	20	mitochondrial	mitochondrial	JJ
cord-262445-54ng7m92	275	21	movements	movement	NNS
cord-262445-54ng7m92	275	22	to	to	IN
cord-262445-54ng7m92	275	23	Drp1	Drp1	NNP
cord-262445-54ng7m92	275	24	levels	level	NNS
cord-262445-54ng7m92	275	25	.	.	.
cord-262445-54ng7m92	276	1	This	this	DT
cord-262445-54ng7m92	276	2	aberrant	aberrant	JJ
cord-262445-54ng7m92	276	3	positioning	positioning	NN
cord-262445-54ng7m92	276	4	of	of	IN
cord-262445-54ng7m92	276	5	mitochondria	mitochondrion	NNS
cord-262445-54ng7m92	276	6	is	be	VBZ
cord-262445-54ng7m92	276	7	accompanied	accompany	VBN
cord-262445-54ng7m92	276	8	by	by	IN
cord-262445-54ng7m92	276	9	the	the	DT
cord-262445-54ng7m92	276	10	collapse	collapse	NN
cord-262445-54ng7m92	276	11	and	and	CC
cord-262445-54ng7m92	276	12	aggregation	aggregation	NN
cord-262445-54ng7m92	276	13	of	of	IN
cord-262445-54ng7m92	276	14	desmin	desmin	NNP
cord-262445-54ng7m92	276	15	confirming	confirm	VBG
cord-262445-54ng7m92	276	16	that	that	IN
cord-262445-54ng7m92	276	17	the	the	DT
cord-262445-54ng7m92	276	18	loss	loss	NN
cord-262445-54ng7m92	276	19	of	of	IN
cord-262445-54ng7m92	276	20	mitochondria	mitochondrion	NNS
cord-262445-54ng7m92	276	21	anchoring	anchor	VBG
cord-262445-54ng7m92	276	22	system	system	NN
cord-262445-54ng7m92	276	23	may	may	MD
cord-262445-54ng7m92	276	24	contribute	contribute	VB
cord-262445-54ng7m92	276	25	to	to	IN
cord-262445-54ng7m92	276	26	mitochondria	mitochondrion	NNS
cord-262445-54ng7m92	276	27	distribution	distribution	NN
cord-262445-54ng7m92	276	28	.	.	.
cord-262445-54ng7m92	277	1	We	-PRON-	PRP
cord-262445-54ng7m92	277	2	conclude	conclude	VBP
cord-262445-54ng7m92	277	3	that	that	IN
cord-262445-54ng7m92	277	4	desmin	desmin	NNP
cord-262445-54ng7m92	277	5	alterations	alteration	NNS
cord-262445-54ng7m92	277	6	accompanied	accompany	VBN
cord-262445-54ng7m92	277	7	by	by	IN
cord-262445-54ng7m92	277	8	increased	increase	VBN
cord-262445-54ng7m92	277	9	Drp1	Drp1	NNP
cord-262445-54ng7m92	277	10	levels	level	NNS
cord-262445-54ng7m92	277	11	enhance	enhance	VBP
cord-262445-54ng7m92	277	12	microtubule	microtubule	NN
cord-262445-54ng7m92	277	13	-	-	HYPH
cord-262445-54ng7m92	277	14	dependent	dependent	JJ
cord-262445-54ng7m92	277	15	trafficking	trafficking	NN
cord-262445-54ng7m92	277	16	promoting	promote	VBG
cord-262445-54ng7m92	277	17	changes	change	NNS
cord-262445-54ng7m92	277	18	in	in	IN
cord-262445-54ng7m92	277	19	mitochondrial	mitochondrial	JJ
cord-262445-54ng7m92	277	20	positioning	positioning	NN
cord-262445-54ng7m92	277	21	unravelling	unravel	VBG
cord-262445-54ng7m92	277	22	a	a	DT
cord-262445-54ng7m92	277	23	hitherto	hitherto	RB
cord-262445-54ng7m92	277	24	unknown	unknown	JJ
cord-262445-54ng7m92	277	25	function	function	NN
cord-262445-54ng7m92	277	26	of	of	IN
cord-262445-54ng7m92	277	27	Drp1	Drp1	NNP
cord-262445-54ng7m92	277	28	in	in	IN
cord-262445-54ng7m92	277	29	the	the	DT
cord-262445-54ng7m92	277	30	regulation	regulation	NN
cord-262445-54ng7m92	277	31	of	of	IN
cord-262445-54ng7m92	277	32	kinesin-1	kinesin-1	NNP
cord-262445-54ng7m92	277	33	complex	complex	NN
cord-262445-54ng7m92	277	34	.	.	.
cord-262445-54ng7m92	278	1	Valentina	Valentina	NNP
cord-262445-54ng7m92	278	2	Taglietti	Taglietti	NNP
cord-262445-54ng7m92	279	1	The	the	DT
cord-262445-54ng7m92	279	2	"	"	``
cord-262445-54ng7m92	279	3	ubiquitous	ubiquitous	JJ
cord-262445-54ng7m92	279	4	"	"	''
cord-262445-54ng7m92	279	5	CCAAT	ccaat	NN
cord-262445-54ng7m92	279	6	-	-	HYPH
cord-262445-54ng7m92	279	7	binding	bind	VBG
cord-262445-54ng7m92	279	8	transcription	transcription	NN
cord-262445-54ng7m92	279	9	factor	factor	NN
cord-262445-54ng7m92	280	1	NF	NF	NNP
cord-262445-54ng7m92	280	2	-	-	HYPH
cord-262445-54ng7m92	280	3	Y	Y	NNP
cord-262445-54ng7m92	280	4	is	be	VBZ
cord-262445-54ng7m92	280	5	a	a	DT
cord-262445-54ng7m92	280	6	trimer	trimer	NN
cord-262445-54ng7m92	280	7	formed	form	VBN
cord-262445-54ng7m92	280	8	by	by	IN
cord-262445-54ng7m92	280	9	the	the	DT
cord-262445-54ng7m92	280	10	histone	histone	NN
cord-262445-54ng7m92	280	11	-	-	HYPH
cord-262445-54ng7m92	280	12	like	like	JJ
cord-262445-54ng7m92	280	13	NF	nf	NN
cord-262445-54ng7m92	280	14	-	-	HYPH
cord-262445-54ng7m92	280	15	YB	YB	NNP
cord-262445-54ng7m92	280	16	/	/	SYM
cord-262445-54ng7m92	280	17	NF	NF	NNP
cord-262445-54ng7m92	280	18	-	-	HYPH
cord-262445-54ng7m92	280	19	YC	YC	NNP
cord-262445-54ng7m92	280	20	and	and	CC
cord-262445-54ng7m92	280	21	the	the	DT
cord-262445-54ng7m92	280	22	sequence	sequence	NN
cord-262445-54ng7m92	280	23	-	-	HYPH
cord-262445-54ng7m92	280	24	specific	specific	JJ
cord-262445-54ng7m92	280	25	NF	nf	NN
cord-262445-54ng7m92	280	26	-	-	HYPH
cord-262445-54ng7m92	280	27	YA	YA	NNP
cord-262445-54ng7m92	280	28	,	,	,
cord-262445-54ng7m92	280	29	present	present	JJ
cord-262445-54ng7m92	280	30	in	in	IN
cord-262445-54ng7m92	280	31	two	two	CD
cord-262445-54ng7m92	280	32	isoforms	isoform	NNS
cord-262445-54ng7m92	280	33	.	.	.
cord-262445-54ng7m92	281	1	All	all	DT
cord-262445-54ng7m92	281	2	three	three	CD
cord-262445-54ng7m92	281	3	subunits	subunit	NNS
cord-262445-54ng7m92	281	4	are	be	VBP
cord-262445-54ng7m92	281	5	required	require	VBN
cord-262445-54ng7m92	281	6	for	for	IN
cord-262445-54ng7m92	281	7	DNA	dna	NN
cord-262445-54ng7m92	281	8	-	-	HYPH
cord-262445-54ng7m92	281	9	binding	binding	NN
cord-262445-54ng7m92	281	10	and	and	CC
cord-262445-54ng7m92	281	11	function	function	NN
cord-262445-54ng7m92	281	12	.	.	.
cord-262445-54ng7m92	282	1	The	the	DT
cord-262445-54ng7m92	282	2	role	role	NN
cord-262445-54ng7m92	282	3	of	of	IN
cord-262445-54ng7m92	282	4	NF	NF	NNP
cord-262445-54ng7m92	282	5	-	-	HYPH
cord-262445-54ng7m92	282	6	Y	Y	NNP
cord-262445-54ng7m92	282	7	in	in	IN
cord-262445-54ng7m92	282	8	muscle	muscle	NN
cord-262445-54ng7m92	282	9	physiology	physiology	NN
cord-262445-54ng7m92	282	10	is	be	VBZ
cord-262445-54ng7m92	282	11	not	not	RB
cord-262445-54ng7m92	282	12	clear	clear	JJ
cord-262445-54ng7m92	282	13	:	:	:
cord-262445-54ng7m92	282	14	if	if	IN
cord-262445-54ng7m92	282	15	overexpressed	overexpresse	VBN
cord-262445-54ng7m92	282	16	,	,	,
cord-262445-54ng7m92	282	17	the	the	DT
cord-262445-54ng7m92	282	18	"	"	``
cord-262445-54ng7m92	282	19	long	long	JJ
cord-262445-54ng7m92	282	20	"	"	''
cord-262445-54ng7m92	282	21	NF	nf	NN
cord-262445-54ng7m92	282	22	-	-	HYPH
cord-262445-54ng7m92	282	23	YA	YA	NNP
cord-262445-54ng7m92	282	24	isoform	isoform	NN
cord-262445-54ng7m92	282	25	favors	favor	VBZ
cord-262445-54ng7m92	282	26	differentiation	differentiation	NN
cord-262445-54ng7m92	282	27	,	,	,
cord-262445-54ng7m92	282	28	yet	yet	CC
cord-262445-54ng7m92	282	29	it	-PRON-	PRP
cord-262445-54ng7m92	282	30	is	be	VBZ
cord-262445-54ng7m92	282	31	negatively	negatively	RB
cord-262445-54ng7m92	282	32	regulated	regulate	VBN
cord-262445-54ng7m92	282	33	during	during	IN
cord-262445-54ng7m92	282	34	the	the	DT
cord-262445-54ng7m92	282	35	process	process	NN
cord-262445-54ng7m92	282	36	.	.	.
cord-262445-54ng7m92	283	1	We	-PRON-	PRP
cord-262445-54ng7m92	283	2	targeted	target	VBD
cord-262445-54ng7m92	283	3	NF	NF	NNP
cord-262445-54ng7m92	283	4	-	-	HYPH
cord-262445-54ng7m92	283	5	YA	YA	NNP
cord-262445-54ng7m92	283	6	Exon	Exon	NNP
cord-262445-54ng7m92	283	7	3	3	CD
cord-262445-54ng7m92	283	8	by	by	IN
cord-262445-54ng7m92	283	9	CRISPR	CRISPR	NNP
cord-262445-54ng7m92	283	10	-	-	HYPH
cord-262445-54ng7m92	283	11	Cas9	Cas9	NNP
cord-262445-54ng7m92	283	12	in	in	IN
cord-262445-54ng7m92	283	13	mouse	mouse	NN
cord-262445-54ng7m92	283	14	C2C12	C2C12	NNP
cord-262445-54ng7m92	283	15	,	,	,
cord-262445-54ng7m92	283	16	thus	thus	RB
cord-262445-54ng7m92	283	17	ablating	ablate	VBG
cord-262445-54ng7m92	283	18	the	the	DT
cord-262445-54ng7m92	283	19	"	"	``
cord-262445-54ng7m92	283	20	long	long	JJ
cord-262445-54ng7m92	283	21	"	"	''
cord-262445-54ng7m92	283	22	NF	nf	NN
cord-262445-54ng7m92	283	23	-	-	HYPH
cord-262445-54ng7m92	283	24	YA	YA	NNP
cord-262445-54ng7m92	283	25	:	:	:
cord-262445-54ng7m92	283	26	despite	despite	IN
cord-262445-54ng7m92	283	27	expression	expression	NN
cord-262445-54ng7m92	283	28	of	of	IN
cord-262445-54ng7m92	283	29	NF	nf	NN
cord-262445-54ng7m92	283	30	-	-	HYPH
cord-262445-54ng7m92	283	31	YA	YA	NNP
cord-262445-54ng7m92	283	32	"	"	''
cord-262445-54ng7m92	283	33	short	short	JJ
cord-262445-54ng7m92	283	34	"	"	''
cord-262445-54ng7m92	283	35	,	,	,
cord-262445-54ng7m92	283	36	differentiation	differentiation	NN
cord-262445-54ng7m92	283	37	is	be	VBZ
cord-262445-54ng7m92	283	38	blocked	block	VBN
cord-262445-54ng7m92	283	39	.	.	.
cord-262445-54ng7m92	284	1	To	to	TO
cord-262445-54ng7m92	284	2	understand	understand	VB
cord-262445-54ng7m92	284	3	the	the	DT
cord-262445-54ng7m92	284	4	NF	NF	NNP
cord-262445-54ng7m92	284	5	-	-	HYPH
cord-262445-54ng7m92	284	6	Y	Y	NNP
cord-262445-54ng7m92	284	7	regulome	regulome	NN
cord-262445-54ng7m92	284	8	in	in	IN
cord-262445-54ng7m92	284	9	a	a	DT
cord-262445-54ng7m92	284	10	more	more	RBR
cord-262445-54ng7m92	284	11	physiological	physiological	JJ
cord-262445-54ng7m92	284	12	system	system	NN
cord-262445-54ng7m92	284	13	,	,	,
cord-262445-54ng7m92	284	14	we	-PRON-	PRP
cord-262445-54ng7m92	284	15	turned	turn	VBD
cord-262445-54ng7m92	284	16	to	to	IN
cord-262445-54ng7m92	284	17	primary	primary	JJ
cord-262445-54ng7m92	284	18	mouse	mouse	NN
cord-262445-54ng7m92	284	19	fetal	fetal	JJ
cord-262445-54ng7m92	284	20	myoblasts	myoblast	NNS
cord-262445-54ng7m92	284	21	,	,	,
cord-262445-54ng7m92	284	22	performing	perform	VBG
cord-262445-54ng7m92	284	23	ChIP	chip	NN
cord-262445-54ng7m92	284	24	-	-	HYPH
cord-262445-54ng7m92	284	25	Seq	Seq	NNP
cord-262445-54ng7m92	284	26	,	,	,
cord-262445-54ng7m92	284	27	RNA	RNA	NNP
cord-262445-54ng7m92	284	28	-	-	HYPH
cord-262445-54ng7m92	284	29	Seq	Seq	NNP
cord-262445-54ng7m92	284	30	after	after	IN
cord-262445-54ng7m92	284	31	NF	NF	NNP
cord-262445-54ng7m92	284	32	-	-	HYPH
cord-262445-54ng7m92	284	33	YB	YB	NNP
cord-262445-54ng7m92	284	34	RNAi	RNAi	NNS
cord-262445-54ng7m92	284	35	,	,	,
cord-262445-54ng7m92	284	36	and	and	CC
cord-262445-54ng7m92	284	37	monitoring	monitor	VBG
cord-262445-54ng7m92	284	38	gene	gene	NN
cord-262445-54ng7m92	284	39	expression	expression	NN
cord-262445-54ng7m92	284	40	from	from	IN
cord-262445-54ng7m92	284	41	myoblasts	myoblast	NNS
cord-262445-54ng7m92	284	42	to	to	IN
cord-262445-54ng7m92	284	43	myotubes	myotubes	NNP
cord-262445-54ng7m92	284	44	.	.	.
cord-262445-54ng7m92	285	1	NF	NF	NNP
cord-262445-54ng7m92	285	2	-	-	HYPH
cord-262445-54ng7m92	285	3	Y	Y	NNP
cord-262445-54ng7m92	285	4	locations	location	NNS
cord-262445-54ng7m92	285	5	are	be	VBP
cord-262445-54ng7m92	285	6	similar	similar	JJ
cord-262445-54ng7m92	285	7	before	before	IN
cord-262445-54ng7m92	285	8	and	and	CC
cord-262445-54ng7m92	285	9	after	after	IN
cord-262445-54ng7m92	285	10	differentiation	differentiation	NN
cord-262445-54ng7m92	285	11	,	,	,
cord-262445-54ng7m92	285	12	despite	despite	IN
cord-262445-54ng7m92	285	13	far	far	RB
cord-262445-54ng7m92	285	14	lower	low	JJR
cord-262445-54ng7m92	285	15	levels	level	NNS
cord-262445-54ng7m92	285	16	of	of	IN
cord-262445-54ng7m92	285	17	NF	nf	NN
cord-262445-54ng7m92	285	18	-	-	HYPH
cord-262445-54ng7m92	285	19	YA	YA	NNP
cord-262445-54ng7m92	285	20	.	.	.
cord-262445-54ng7m92	286	1	Notably	notably	RB
cord-262445-54ng7m92	286	2	,	,	,
cord-262445-54ng7m92	286	3	the	the	DT
cord-262445-54ng7m92	286	4	NF	NF	NNP
cord-262445-54ng7m92	286	5	-	-	HYPH
cord-262445-54ng7m92	286	6	Y	Y	NNP
cord-262445-54ng7m92	286	7	regulome	regulome	NN
cord-262445-54ng7m92	286	8	is	be	VBZ
cord-262445-54ng7m92	286	9	devoid	devoid	JJ
cord-262445-54ng7m92	286	10	of	of	IN
cord-262445-54ng7m92	286	11	binding	bind	VBG
cord-262445-54ng7m92	286	12	sites	site	NNS
cord-262445-54ng7m92	286	13	of	of	IN
cord-262445-54ng7m92	286	14	MRFs	mrf	NNS
cord-262445-54ng7m92	286	15	-Muscle	-Muscle	.
cord-262445-54ng7m92	286	16	Regulatory	Regulatory	NNP
cord-262445-54ng7m92	286	17	Factors	Factors	NNP
cord-262445-54ng7m92	286	18	-	-	:
cord-262445-54ng7m92	286	19	and	and	CC
cord-262445-54ng7m92	286	20	myotubes	myotubes	JJ
cord-262445-54ng7m92	286	21	-	-	HYPH
cord-262445-54ng7m92	286	22	specific	specific	JJ
cord-262445-54ng7m92	286	23	genes	gene	NNS
cord-262445-54ng7m92	286	24	are	be	VBP
cord-262445-54ng7m92	286	25	not	not	RB
cord-262445-54ng7m92	286	26	targeted	target	VBN
cord-262445-54ng7m92	286	27	.	.	.
cord-262445-54ng7m92	287	1	Instead	instead	RB
cord-262445-54ng7m92	287	2	,	,	,
cord-262445-54ng7m92	287	3	we	-PRON-	PRP
cord-262445-54ng7m92	287	4	observe	observe	VBP
cord-262445-54ng7m92	287	5	a	a	DT
cord-262445-54ng7m92	287	6	positive	positive	JJ
cord-262445-54ng7m92	287	7	functional	functional	JJ
cord-262445-54ng7m92	287	8	partnership	partnership	NN
cord-262445-54ng7m92	287	9	with	with	IN
cord-262445-54ng7m92	287	10	SREBPs	srebps	NN
cord-262445-54ng7m92	287	11	,	,	,
cord-262445-54ng7m92	287	12	master	master	NN
cord-262445-54ng7m92	287	13	regulators	regulator	NNS
cord-262445-54ng7m92	287	14	of	of	IN
cord-262445-54ng7m92	287	15	lipids	lipid	NNS
cord-262445-54ng7m92	287	16	biosynthesis	biosynthesis	NN
cord-262445-54ng7m92	287	17	,	,	,
cord-262445-54ng7m92	287	18	and	and	CC
cord-262445-54ng7m92	287	19	a	a	DT
cord-262445-54ng7m92	287	20	negative	negative	JJ
cord-262445-54ng7m92	287	21	one	one	NN
cord-262445-54ng7m92	287	22	on	on	IN
cord-262445-54ng7m92	287	23	cell	cell	NN
cord-262445-54ng7m92	287	24	-	-	HYPH
cord-262445-54ng7m92	287	25	cycle	cycle	NN
cord-262445-54ng7m92	287	26	genes	gene	NNS
cord-262445-54ng7m92	287	27	.	.	.
cord-262445-54ng7m92	288	1	SREBP-2	SREBP-2	NNP
cord-262445-54ng7m92	288	2	is	be	VBZ
cord-262445-54ng7m92	288	3	active	active	JJ
cord-262445-54ng7m92	288	4	in	in	IN
cord-262445-54ng7m92	288	5	differentiation	differentiation	NN
cord-262445-54ng7m92	288	6	and	and	CC
cord-262445-54ng7m92	288	7	bound	bind	VBN
cord-262445-54ng7m92	288	8	to	to	IN
cord-262445-54ng7m92	288	9	promoters	promoter	NNS
cord-262445-54ng7m92	288	10	of	of	IN
cord-262445-54ng7m92	288	11	genes	gene	NNS
cord-262445-54ng7m92	288	12	co	co	VBD
cord-262445-54ng7m92	288	13	-	-	VBN
cord-262445-54ng7m92	288	14	regulated	regulate	VBN
cord-262445-54ng7m92	288	15	with	with	IN
cord-262445-54ng7m92	288	16	NF	nf	NN
cord-262445-54ng7m92	289	1	-Y.	-Y.	NFP
cord-262445-54ng7m92	289	2	These	these	DT
cord-262445-54ng7m92	289	3	data	datum	NNS
cord-262445-54ng7m92	289	4	establish	establish	VBP
cord-262445-54ng7m92	289	5	that	that	DT
cord-262445-54ng7m92	289	6	NF	NF	NNP
cord-262445-54ng7m92	289	7	-	-	HYPH
cord-262445-54ng7m92	289	8	Y	Y	NNP
cord-262445-54ng7m92	289	9	,	,	,
cord-262445-54ng7m92	289	10	and	and	CC
cord-262445-54ng7m92	289	11	specifically	specifically	RB
cord-262445-54ng7m92	289	12	the	the	DT
cord-262445-54ng7m92	289	13	"	"	``
cord-262445-54ng7m92	289	14	long	long	JJ
cord-262445-54ng7m92	289	15	"	"	''
cord-262445-54ng7m92	289	16	NF	nf	NN
cord-262445-54ng7m92	289	17	-	-	HYPH
cord-262445-54ng7m92	289	18	YA	YA	NNP
cord-262445-54ng7m92	289	19	isoform	isoform	NN
cord-262445-54ng7m92	289	20	,	,	,
cord-262445-54ng7m92	289	21	is	be	VBZ
cord-262445-54ng7m92	289	22	essential	essential	JJ
cord-262445-54ng7m92	289	23	for	for	IN
cord-262445-54ng7m92	289	24	myotubes	myotubes	NNP
cord-262445-54ng7m92	289	25	formation	formation	NN
cord-262445-54ng7m92	289	26	,	,	,
cord-262445-54ng7m92	289	27	but	but	CC
cord-262445-54ng7m92	289	28	marginally	marginally	RB
cord-262445-54ng7m92	289	29	,	,	,
cord-262445-54ng7m92	290	1	if	if	IN
cord-262445-54ng7m92	290	2	at	at	RB
cord-262445-54ng7m92	290	3	all	all	RB
cord-262445-54ng7m92	290	4	,	,	,
cord-262445-54ng7m92	290	5	through	through	IN
cord-262445-54ng7m92	290	6	direct	direct	JJ
cord-262445-54ng7m92	290	7	activation	activation	NN
cord-262445-54ng7m92	290	8	of	of	IN
cord-262445-54ng7m92	290	9	muscle	muscle	NN
cord-262445-54ng7m92	290	10	-	-	HYPH
cord-262445-54ng7m92	290	11	specific	specific	JJ
cord-262445-54ng7m92	290	12	genes	gene	NNS
cord-262445-54ng7m92	290	13	.	.	.
cord-262445-54ng7m92	291	1	Instead	instead	RB
cord-262445-54ng7m92	291	2	,	,	,
cord-262445-54ng7m92	291	3	it	-PRON-	PRP
cord-262445-54ng7m92	291	4	teams	team	VBZ
cord-262445-54ng7m92	291	5	up	up	RP
cord-262445-54ng7m92	291	6	with	with	IN
cord-262445-54ng7m92	291	7	SREBPs	srebp	NNS
cord-262445-54ng7m92	291	8	to	to	TO
cord-262445-54ng7m92	291	9	activate	activate	VB
cord-262445-54ng7m92	291	10	crucial	crucial	JJ
cord-262445-54ng7m92	291	11	steps	step	NNS
cord-262445-54ng7m92	291	12	of	of	IN
cord-262445-54ng7m92	291	13	lipids	lipid	NNS
cord-262445-54ng7m92	291	14	metabolic	metabolic	JJ
cord-262445-54ng7m92	291	15	pathways	pathway	NNS
cord-262445-54ng7m92	291	16	required	require	VBN
cord-262445-54ng7m92	291	17	for	for	IN
cord-262445-54ng7m92	291	18	the	the	DT
cord-262445-54ng7m92	291	19	process	process	NN
cord-262445-54ng7m92	291	20	.	.	.
cord-262445-54ng7m92	292	1	The	the	DT
cord-262445-54ng7m92	292	2	NF	NF	NNP
cord-262445-54ng7m92	292	3	-	-	HYPH
cord-262445-54ng7m92	292	4	Y	Y	NNP
cord-262445-54ng7m92	292	5	/	/	SYM
cord-262445-54ng7m92	292	6	SREBPs	srebps	NN
cord-262445-54ng7m92	292	7	partnership	partnership	NN
cord-262445-54ng7m92	292	8	will	will	MD
cord-262445-54ng7m92	292	9	be	be	VB
cord-262445-54ng7m92	292	10	discussed	discuss	VBN
cord-262445-54ng7m92	292	11	.	.	.
cord-262445-54ng7m92	293	1	CK2	CK2	NNP
cord-262445-54ng7m92	293	2	is	be	VBZ
cord-262445-54ng7m92	293	3	a	a	DT
cord-262445-54ng7m92	293	4	tetrameric	tetrameric	JJ
cord-262445-54ng7m92	293	5	protein	protein	NN
cord-262445-54ng7m92	293	6	-	-	HYPH
cord-262445-54ng7m92	293	7	kinase	kinase	NN
cord-262445-54ng7m92	293	8	,	,	,
cord-262445-54ng7m92	293	9	composed	compose	VBN
cord-262445-54ng7m92	293	10	of	of	IN
cord-262445-54ng7m92	293	11	two	two	CD
cord-262445-54ng7m92	293	12	catalytic	catalytic	JJ
cord-262445-54ng7m92	293	13	(	(	-LRB-
cord-262445-54ng7m92	293	14			NNP
cord-262445-54ng7m92	293	15	and/or	and/or	CC
cord-262445-54ng7m92	293	16			NNP
cord-262445-54ng7m92	293	17	'	'	''
cord-262445-54ng7m92	293	18	)	)	-RRB-
cord-262445-54ng7m92	293	19	and	and	CC
cord-262445-54ng7m92	293	20	two	two	CD
cord-262445-54ng7m92	293	21	regulatory	regulatory	JJ
cord-262445-54ng7m92	293	22	β	β	NN
cord-262445-54ng7m92	293	23	-	-	HYPH
cord-262445-54ng7m92	293	24	subunits	subunit	NNS
cord-262445-54ng7m92	293	25	.	.	.
cord-262445-54ng7m92	294	1	Our	-PRON-	PRP$
cord-262445-54ng7m92	294	2	study	study	NN
cord-262445-54ng7m92	294	3	provides	provide	VBZ
cord-262445-54ng7m92	294	4	the	the	DT
cord-262445-54ng7m92	294	5	first	first	JJ
cord-262445-54ng7m92	294	6	molecular	molecular	JJ
cord-262445-54ng7m92	294	7	and	and	CC
cord-262445-54ng7m92	294	8	cellular	cellular	JJ
cord-262445-54ng7m92	294	9	characterization	characterization	NN
cord-262445-54ng7m92	294	10	of	of	IN
cord-262445-54ng7m92	294	11	the	the	DT
cord-262445-54ng7m92	294	12	different	different	JJ
cord-262445-54ng7m92	294	13	CK2-subunits	ck2-subunit	NNS
cord-262445-54ng7m92	294	14	highlighting	highlight	VBG
cord-262445-54ng7m92	294	15	their	-PRON-	PRP$
cord-262445-54ng7m92	294	16	individual	individual	JJ
cord-262445-54ng7m92	294	17	roles	role	NNS
cord-262445-54ng7m92	294	18	in	in	IN
cord-262445-54ng7m92	294	19	skeletal	skeletal	JJ
cord-262445-54ng7m92	294	20	muscle	muscle	NN
cord-262445-54ng7m92	294	21	specification	specification	NN
cord-262445-54ng7m92	294	22	and	and	CC
cord-262445-54ng7m92	294	23	differentiation	differentiation	NN
cord-262445-54ng7m92	294	24	.	.	.
cord-262445-54ng7m92	295	1	Analysis	analysis	NN
cord-262445-54ng7m92	295	2	of	of	IN
cord-262445-54ng7m92	295	3	C2C12	c2c12	JJ
cord-262445-54ng7m92	295	4	cells	cell	NNS
cord-262445-54ng7m92	295	5	knockout	knockout	NN
cord-262445-54ng7m92	295	6	for	for	IN
cord-262445-54ng7m92	295	7	each	each	DT
cord-262445-54ng7m92	295	8	CK2-subunit	CK2-subunit	NNP
cord-262445-54ng7m92	295	9	reveals	reveal	VBZ
cord-262445-54ng7m92	295	10	that	that	DT
cord-262445-54ng7m92	295	11	:	:	:
cord-262445-54ng7m92	295	12	i	i	LS
cord-262445-54ng7m92	295	13	)	)	-RRB-
cord-262445-54ng7m92	296	1	CK2β	CK2β	NNP
cord-262445-54ng7m92	296	2	is	be	VBZ
cord-262445-54ng7m92	296	3	mandatory	mandatory	JJ
cord-262445-54ng7m92	296	4	for	for	IN
cord-262445-54ng7m92	296	5	the	the	DT
cord-262445-54ng7m92	296	6	expression	expression	NN
cord-262445-54ng7m92	296	7	of	of	IN
cord-262445-54ng7m92	296	8	the	the	DT
cord-262445-54ng7m92	296	9	muscle	muscle	NN
cord-262445-54ng7m92	296	10	master	master	NN
cord-262445-54ng7m92	296	11	-	-	HYPH
cord-262445-54ng7m92	296	12	regulator	regulator	NN
cord-262445-54ng7m92	296	13	MyoD	MyoD	NNP
cord-262445-54ng7m92	296	14	in	in	IN
cord-262445-54ng7m92	296	15	proliferating	proliferate	VBG
cord-262445-54ng7m92	296	16	myoblasts	myoblast	NNS
cord-262445-54ng7m92	296	17	,	,	,
cord-262445-54ng7m92	296	18	thus	thus	RB
cord-262445-54ng7m92	296	19	controlling	control	VBG
cord-262445-54ng7m92	296	20	both	both	DT
cord-262445-54ng7m92	296	21	myogenic	myogenic	JJ
cord-262445-54ng7m92	296	22	commitment	commitment	NN
cord-262445-54ng7m92	296	23	and	and	CC
cord-262445-54ng7m92	296	24	subsequent	subsequent	JJ
cord-262445-54ng7m92	296	25	muscle	muscle	NN
cord-262445-54ng7m92	296	26	-	-	HYPH
cord-262445-54ng7m92	296	27	specific	specific	JJ
cord-262445-54ng7m92	296	28	gene	gene	NN
cord-262445-54ng7m92	296	29	expression	expression	NN
cord-262445-54ng7m92	296	30	and	and	CC
cord-262445-54ng7m92	296	31	myotube	myotube	NN
cord-262445-54ng7m92	296	32	formation	formation	NN
cord-262445-54ng7m92	296	33	;	;	.
cord-262445-54ng7m92	297	1	ii	ii	LS
cord-262445-54ng7m92	297	2	)	)	-RRB-
cord-262445-54ng7m92	297	3	CK2	CK2	NNP
cord-262445-54ng7m92	297	4	is	be	VBZ
cord-262445-54ng7m92	297	5	involved	involve	VBN
cord-262445-54ng7m92	297	6	in	in	IN
cord-262445-54ng7m92	297	7	the	the	DT
cord-262445-54ng7m92	297	8	activation	activation	NN
cord-262445-54ng7m92	297	9	of	of	IN
cord-262445-54ng7m92	297	10	the	the	DT
cord-262445-54ng7m92	297	11	muscle	muscle	NN
cord-262445-54ng7m92	297	12	-	-	HYPH
cord-262445-54ng7m92	297	13	specific	specific	JJ
cord-262445-54ng7m92	297	14	gene	gene	NN
cord-262445-54ng7m92	297	15	-	-	HYPH
cord-262445-54ng7m92	297	16	program	program	NN
cord-262445-54ng7m92	297	17	;	;	:
cord-262445-54ng7m92	297	18	iii	iii	LS
cord-262445-54ng7m92	297	19	)	)	-RRB-
cord-262445-54ng7m92	297	20	CK2'-activity	CK2'-activity	NNP
cord-262445-54ng7m92	297	21	regulates	regulate	VBZ
cord-262445-54ng7m92	297	22	myoblast	myoblast	NN
cord-262445-54ng7m92	297	23	fusion	fusion	NN
cord-262445-54ng7m92	297	24	by	by	IN
cord-262445-54ng7m92	297	25	mediating	mediate	VBG
cord-262445-54ng7m92	297	26	plasma	plasma	NN
cord-262445-54ng7m92	297	27	membrane	membrane	NN
cord-262445-54ng7m92	297	28	translocation	translocation	NN
cord-262445-54ng7m92	297	29	of	of	IN
cord-262445-54ng7m92	297	30	fusogenic	fusogenic	JJ
cord-262445-54ng7m92	297	31	proteins	protein	NNS
cord-262445-54ng7m92	297	32	essential	essential	JJ
cord-262445-54ng7m92	297	33	for	for	IN
cord-262445-54ng7m92	297	34	membrane	membrane	NN
cord-262445-54ng7m92	297	35	coalescence	coalescence	NN
cord-262445-54ng7m92	297	36	,	,	,
cord-262445-54ng7m92	297	37	like	like	IN
cord-262445-54ng7m92	297	38	myomixer	myomixer	NNP
cord-262445-54ng7m92	297	39	.	.	.
cord-262445-54ng7m92	298	1	Accordingly	accordingly	RB
cord-262445-54ng7m92	298	2	,	,	,
cord-262445-54ng7m92	298	3	CK2	CK2	NNP
cord-262445-54ng7m92	298	4	'	'	POS
cord-262445-54ng7m92	298	5	overexpression	overexpression	NN
cord-262445-54ng7m92	298	6	in	in	IN
cord-262445-54ng7m92	298	7	C2C12	c2c12	JJ
cord-262445-54ng7m92	298	8	cells	cell	NNS
cord-262445-54ng7m92	298	9	and	and	CC
cord-262445-54ng7m92	298	10	in	in	IN
cord-262445-54ng7m92	298	11	mouse	mouse	NN
cord-262445-54ng7m92	298	12	regenerating	regenerate	VBG
cord-262445-54ng7m92	298	13	muscle	muscle	NN
cord-262445-54ng7m92	298	14	is	be	VBZ
cord-262445-54ng7m92	298	15	sufficient	sufficient	JJ
cord-262445-54ng7m92	298	16	to	to	TO
cord-262445-54ng7m92	298	17	increase	increase	VB
cord-262445-54ng7m92	298	18	myofiber	myofiber	NN
cord-262445-54ng7m92	298	19	size	size	NN
cord-262445-54ng7m92	298	20	and	and	CC
cord-262445-54ng7m92	298	21	myonuclei	myonuclei	NN
cord-262445-54ng7m92	298	22	content	content	NN
cord-262445-54ng7m92	298	23	via	via	IN
cord-262445-54ng7m92	298	24	enhanced	enhanced	JJ
cord-262445-54ng7m92	298	25	satellite	satellite	NN
cord-262445-54ng7m92	298	26	cell	cell	NN
cord-262445-54ng7m92	298	27	fusion	fusion	NN
cord-262445-54ng7m92	298	28	.	.	.
cord-262445-54ng7m92	299	1	Consistent	consistent	JJ
cord-262445-54ng7m92	299	2	with	with	IN
cord-262445-54ng7m92	299	3	these	these	DT
cord-262445-54ng7m92	299	4	results	result	NNS
cord-262445-54ng7m92	299	5	,	,	,
cord-262445-54ng7m92	299	6	pharmacological	pharmacological	JJ
cord-262445-54ng7m92	299	7	inhibition	inhibition	NN
cord-262445-54ng7m92	299	8	of	of	IN
cord-262445-54ng7m92	299	9	CK2-activity	ck2-activity	NN
cord-262445-54ng7m92	299	10	substantially	substantially	RB
cord-262445-54ng7m92	299	11	blocks	block	VBZ
cord-262445-54ng7m92	299	12	the	the	DT
cord-262445-54ng7m92	299	13	expression	expression	NN
cord-262445-54ng7m92	299	14	of	of	IN
cord-262445-54ng7m92	299	15	myogenic	myogenic	NNP
cord-262445-54ng7m92	299	16	markers	marker	NNS
cord-262445-54ng7m92	299	17	and	and	CC
cord-262445-54ng7m92	299	18	muscle	muscle	NN
cord-262445-54ng7m92	299	19	cell	cell	NN
cord-262445-54ng7m92	299	20	fusion	fusion	NN
cord-262445-54ng7m92	299	21	both	both	CC
cord-262445-54ng7m92	299	22	in	in	IN
cord-262445-54ng7m92	299	23	vitro	vitro	FW
cord-262445-54ng7m92	299	24	,	,	,
cord-262445-54ng7m92	299	25	in	in	IN
cord-262445-54ng7m92	299	26	C2C12	c2c12	JJ
cord-262445-54ng7m92	299	27	and	and	CC
cord-262445-54ng7m92	299	28	primary	primary	JJ
cord-262445-54ng7m92	299	29	myoblasts	myoblast	NNS
cord-262445-54ng7m92	299	30	,	,	,
cord-262445-54ng7m92	299	31	and	and	CC
cord-262445-54ng7m92	299	32	in	in	IN
cord-262445-54ng7m92	299	33	vivo	vivo	NNP
cord-262445-54ng7m92	299	34	,	,	,
cord-262445-54ng7m92	299	35	in	in	IN
cord-262445-54ng7m92	299	36	mouse	mouse	NN
cord-262445-54ng7m92	299	37	regenerating	regenerate	VBG
cord-262445-54ng7m92	299	38	muscle	muscle	NN
cord-262445-54ng7m92	299	39	and	and	CC
cord-262445-54ng7m92	299	40	zebrafish	zebrafish	NN
cord-262445-54ng7m92	299	41	development	development	NN
cord-262445-54ng7m92	299	42	.	.	.
cord-262445-54ng7m92	300	1	Concluding	conclude	VBG
cord-262445-54ng7m92	300	2	,	,	,
cord-262445-54ng7m92	300	3	our	-PRON-	PRP$
cord-262445-54ng7m92	300	4	work	work	NN
cord-262445-54ng7m92	300	5	describes	describe	VBZ
cord-262445-54ng7m92	300	6	the	the	DT
cord-262445-54ng7m92	300	7	specific	specific	JJ
cord-262445-54ng7m92	300	8	and	and	CC
cord-262445-54ng7m92	300	9	coordinated	coordinated	JJ
cord-262445-54ng7m92	300	10	functions	function	NNS
cord-262445-54ng7m92	300	11	of	of	IN
cord-262445-54ng7m92	300	12	CK2-subunits	ck2-subunit	NNS
cord-262445-54ng7m92	300	13	in	in	IN
cord-262445-54ng7m92	300	14	orchestrating	orchestrate	VBG
cord-262445-54ng7m92	300	15	muscle	muscle	NN
cord-262445-54ng7m92	300	16	differentiation	differentiation	NN
cord-262445-54ng7m92	300	17	and	and	CC
cord-262445-54ng7m92	300	18	fusogenic	fusogenic	JJ
cord-262445-54ng7m92	300	19	activity	activity	NN
cord-262445-54ng7m92	300	20	,	,	,
cord-262445-54ng7m92	300	21	highlighting	highlight	VBG
cord-262445-54ng7m92	300	22	CK2	ck2	NN
cord-262445-54ng7m92	300	23	relevance	relevance	NN
cord-262445-54ng7m92	300	24	in	in	IN
cord-262445-54ng7m92	300	25	the	the	DT
cord-262445-54ng7m92	300	26	physiopathology	physiopathology	NN
cord-262445-54ng7m92	300	27	of	of	IN
cord-262445-54ng7m92	300	28	skeletal	skeletal	JJ
cord-262445-54ng7m92	300	29	muscle	muscle	NN
cord-262445-54ng7m92	300	30	tissue	tissue	NN
cord-262445-54ng7m92	300	31	.	.	.
cord-262445-54ng7m92	301	1	Fibro	fibro	NN
cord-262445-54ng7m92	301	2	/	/	SYM
cord-262445-54ng7m92	301	3	adipogenic	adipogenic	JJ
cord-262445-54ng7m92	301	4	progenitors	progenitor	NNS
cord-262445-54ng7m92	301	5	(	(	-LRB-
cord-262445-54ng7m92	301	6	FAPs	fap	NNS
cord-262445-54ng7m92	301	7	)	)	-RRB-
cord-262445-54ng7m92	301	8	are	be	VBP
cord-262445-54ng7m92	301	9	muscle	muscle	NN
cord-262445-54ng7m92	301	10	interstitial	interstitial	JJ
cord-262445-54ng7m92	301	11	progenitors	progenitor	NNS
cord-262445-54ng7m92	301	12	mediating	mediate	VBG
cord-262445-54ng7m92	301	13	pro	pro	JJ
cord-262445-54ng7m92	301	14	-	-	JJ
cord-262445-54ng7m92	301	15	myogenic	myogenic	JJ
cord-262445-54ng7m92	301	16	signals	signal	NNS
cord-262445-54ng7m92	301	17	that	that	WDT
cord-262445-54ng7m92	301	18	are	be	VBP
cord-262445-54ng7m92	301	19	critical	critical	JJ
cord-262445-54ng7m92	301	20	in	in	IN
cord-262445-54ng7m92	301	21	muscle	muscle	NN
cord-262445-54ng7m92	301	22	homeostasis	homeostasis	NN
cord-262445-54ng7m92	301	23	and	and	CC
cord-262445-54ng7m92	301	24	regeneration	regeneration	NN
cord-262445-54ng7m92	301	25	.	.	.
cord-262445-54ng7m92	302	1	In	in	IN
cord-262445-54ng7m92	302	2	pathological	pathological	JJ
cord-262445-54ng7m92	302	3	conditions	condition	NNS
cord-262445-54ng7m92	302	4	,	,	,
cord-262445-54ng7m92	302	5	including	include	VBG
cord-262445-54ng7m92	302	6	ageing	age	VBG
cord-262445-54ng7m92	302	7	and	and	CC
cord-262445-54ng7m92	302	8	myopathies	myopathy	NNS
cord-262445-54ng7m92	302	9	,	,	,
cord-262445-54ng7m92	302	10	the	the	DT
cord-262445-54ng7m92	302	11	autocrine	autocrine	NN
cord-262445-54ng7m92	302	12	/	/	SYM
cord-262445-54ng7m92	302	13	paracrine	paracrine	JJ
cord-262445-54ng7m92	302	14	constraints	constraint	NNS
cord-262445-54ng7m92	302	15	controlling	control	VBG
cord-262445-54ng7m92	302	16	FAP	fap	VB
cord-262445-54ng7m92	302	17	adipogenic	adipogenic	JJ
cord-262445-54ng7m92	302	18	potential	potential	NN
cord-262445-54ng7m92	302	19	are	be	VBP
cord-262445-54ng7m92	302	20	released	release	VBN
cord-262445-54ng7m92	302	21	causing	cause	VBG
cord-262445-54ng7m92	302	22	the	the	DT
cord-262445-54ng7m92	302	23	formation	formation	NN
cord-262445-54ng7m92	302	24	of	of	IN
cord-262445-54ng7m92	302	25	fat	fat	JJ
cord-262445-54ng7m92	302	26	infiltrates	infiltrate	NNS
cord-262445-54ng7m92	302	27	.	.	.
cord-262445-54ng7m92	303	1	To	to	TO
cord-262445-54ng7m92	303	2	reveal	reveal	VB
cord-262445-54ng7m92	303	3	pathways	pathway	NNS
cord-262445-54ng7m92	303	4	that	that	WDT
cord-262445-54ng7m92	303	5	transduce	transduce	VBP
cord-262445-54ng7m92	303	6	the	the	DT
cord-262445-54ng7m92	303	7	niche	niche	NN
cord-262445-54ng7m92	303	8	messages	message	NNS
cord-262445-54ng7m92	303	9	controlling	control	VBG
cord-262445-54ng7m92	303	10	FAP	FAP	NNP
cord-262445-54ng7m92	303	11	adipogenesis	adipogenesis	NNP
cord-262445-54ng7m92	303	12	,	,	,
cord-262445-54ng7m92	303	13	we	-PRON-	PRP
cord-262445-54ng7m92	303	14	have	have	VBP
cord-262445-54ng7m92	303	15	screened	screen	VBN
cord-262445-54ng7m92	303	16	a	a	DT
cord-262445-54ng7m92	303	17	library	library	NN
cord-262445-54ng7m92	303	18	of	of	IN
cord-262445-54ng7m92	303	19	inhibitors	inhibitor	NNS
cord-262445-54ng7m92	303	20	targeting	target	VBG
cord-262445-54ng7m92	303	21	a	a	DT
cord-262445-54ng7m92	303	22	large	large	JJ
cord-262445-54ng7m92	303	23	fraction	fraction	NN
cord-262445-54ng7m92	303	24	of	of	IN
cord-262445-54ng7m92	303	25	the	the	DT
cord-262445-54ng7m92	303	26	human	human	JJ
cord-262445-54ng7m92	303	27	/	/	SYM
cord-262445-54ng7m92	303	28	murine	murine	JJ
cord-262445-54ng7m92	303	29	kinome	kinome	NNP
cord-262445-54ng7m92	303	30	,	,	,
cord-262445-54ng7m92	303	31	looking	look	VBG
cord-262445-54ng7m92	303	32	for	for	IN
cord-262445-54ng7m92	303	33	molecules	molecule	NNS
cord-262445-54ng7m92	303	34	with	with	IN
cord-262445-54ng7m92	303	35	a	a	DT
cord-262445-54ng7m92	303	36	potential	potential	NN
cord-262445-54ng7m92	303	37	to	to	TO
cord-262445-54ng7m92	303	38	modulate	modulate	VB
cord-262445-54ng7m92	303	39	FAP	fap	NN
cord-262445-54ng7m92	303	40	differentiation	differentiation	NN
cord-262445-54ng7m92	303	41	.	.	.
cord-262445-54ng7m92	304	1	Hit	hit	VB
cord-262445-54ng7m92	304	2	selection	selection	NN
cord-262445-54ng7m92	304	3	criteria	criterion	NNS
cord-262445-54ng7m92	304	4	enrich	enrich	VBP
cord-262445-54ng7m92	304	5	compounds	compound	NNS
cord-262445-54ng7m92	304	6	targeting	target	VBG
cord-262445-54ng7m92	304	7	Glycogen	Glycogen	NNP
cord-262445-54ng7m92	304	8	Synthase	Synthase	NNP
cord-262445-54ng7m92	304	9	Kinase	Kinase	NNP
cord-262445-54ng7m92	304	10	3	3	CD
cord-262445-54ng7m92	304	11	(	(	-LRB-
cord-262445-54ng7m92	304	12	GSK3	GSK3	NNP
cord-262445-54ng7m92	304	13	)	)	-RRB-
cord-262445-54ng7m92	304	14	,	,	,
cord-262445-54ng7m92	304	15	thus	thus	RB
cord-262445-54ng7m92	304	16	unveiling	unveil	VBG
cord-262445-54ng7m92	304	17	its	-PRON-	PRP$
cord-262445-54ng7m92	304	18	crucial	crucial	JJ
cord-262445-54ng7m92	304	19	role	role	NN
cord-262445-54ng7m92	304	20	in	in	IN
cord-262445-54ng7m92	304	21	FAP	FAP	NNP
cord-262445-54ng7m92	304	22	adipogenesis	adipogenesis	NNP
cord-262445-54ng7m92	304	23	.	.	.
cord-262445-54ng7m92	305	1	Consistently	consistently	RB
cord-262445-54ng7m92	305	2	,	,	,
cord-262445-54ng7m92	305	3	we	-PRON-	PRP
cord-262445-54ng7m92	305	4	show	show	VBP
cord-262445-54ng7m92	305	5	that	that	IN
cord-262445-54ng7m92	305	6	the	the	DT
cord-262445-54ng7m92	305	7	pharmacological	pharmacological	JJ
cord-262445-54ng7m92	305	8	blockade	blockade	NN
cord-262445-54ng7m92	305	9	of	of	IN
cord-262445-54ng7m92	305	10	GSK3	GSK3	NNP
cord-262445-54ng7m92	305	11	,	,	,
cord-262445-54ng7m92	305	12	by	by	IN
cord-262445-54ng7m92	305	13	using	use	VBG
cord-262445-54ng7m92	305	14	the	the	DT
cord-262445-54ng7m92	305	15	high	high	RB
cord-262445-54ng7m92	305	16	-	-	HYPH
cord-262445-54ng7m92	305	17	selective	selective	JJ
cord-262445-54ng7m92	305	18	inhibitor	inhibitor	NN
cord-262445-54ng7m92	305	19	LY2090314	LY2090314	NNP
cord-262445-54ng7m92	305	20	,	,	,
cord-262445-54ng7m92	305	21	severely	severely	RB
cord-262445-54ng7m92	305	22	impedes	impede	VBZ
cord-262445-54ng7m92	305	23	FAP	fap	NN
cord-262445-54ng7m92	305	24	adipogenesis	adipogenesis	NN
cord-262445-54ng7m92	305	25	ex	ex	NN
cord-262445-54ng7m92	305	26	vivo	vivo	NN
cord-262445-54ng7m92	305	27	while	while	IN
cord-262445-54ng7m92	305	28	limiting	limit	VBG
cord-262445-54ng7m92	305	29	intramuscular	intramuscular	JJ
cord-262445-54ng7m92	305	30	fat	fat	JJ
cord-262445-54ng7m92	305	31	infiltrations	infiltration	NNS
cord-262445-54ng7m92	305	32	upon	upon	IN
cord-262445-54ng7m92	305	33	glycerol	glycerol	NN
cord-262445-54ng7m92	305	34	-	-	HYPH
cord-262445-54ng7m92	305	35	induced	induce	VBN
cord-262445-54ng7m92	305	36	muscle	muscle	NN
cord-262445-54ng7m92	305	37	injury	injury	NN
cord-262445-54ng7m92	305	38	,	,	,
cord-262445-54ng7m92	305	39	in	in	IN
cord-262445-54ng7m92	305	40	vivo	vivo	NNP
cord-262445-54ng7m92	305	41	.	.	.
cord-262445-54ng7m92	306	1	By	by	IN
cord-262445-54ng7m92	306	2	exploiting	exploit	VBG
cord-262445-54ng7m92	306	3	high	high	JJ
cord-262445-54ng7m92	306	4	-	-	HYPH
cord-262445-54ng7m92	306	5	dimensional	dimensional	JJ
cord-262445-54ng7m92	306	6	single	single	JJ
cord-262445-54ng7m92	306	7	-	-	HYPH
cord-262445-54ng7m92	306	8	cell	cell	NN
cord-262445-54ng7m92	306	9	mass	mass	NN
cord-262445-54ng7m92	306	10	cytometry	cytometry	NN
cord-262445-54ng7m92	306	11	,	,	,
cord-262445-54ng7m92	306	12	we	-PRON-	PRP
cord-262445-54ng7m92	306	13	demonstrate	demonstrate	VBP
cord-262445-54ng7m92	306	14	that	that	IN
cord-262445-54ng7m92	306	15	-catenin	-catenin	HYPH
cord-262445-54ng7m92	306	16	down	down	IN
cord-262445-54ng7m92	306	17	-	-	HYPH
cord-262445-54ng7m92	306	18	regulation	regulation	NN
cord-262445-54ng7m92	306	19	is	be	VBZ
cord-262445-54ng7m92	306	20	critical	critical	JJ
cord-262445-54ng7m92	306	21	for	for	IN
cord-262445-54ng7m92	306	22	PPAR	PPAR	NNP
cord-262445-54ng7m92	306	23	expression	expression	NN
cord-262445-54ng7m92	306	24	.	.	.
cord-262445-54ng7m92	307	1	LY2090314	LY2090314	NNP
cord-262445-54ng7m92	307	2	,	,	,
cord-262445-54ng7m92	307	3	by	by	IN
cord-262445-54ng7m92	307	4	targeting	target	VBG
cord-262445-54ng7m92	307	5	GSK3	GSK3	NNP
cord-262445-54ng7m92	307	6	,	,	,
cord-262445-54ng7m92	307	7	counteracts	counteract	VBZ
cord-262445-54ng7m92	307	8	this	this	DT
cord-262445-54ng7m92	307	9	process	process	NN
cord-262445-54ng7m92	307	10	and	and	CC
cord-262445-54ng7m92	307	11	prevents	prevent	VBZ
cord-262445-54ng7m92	307	12	FAP	fap	NN
cord-262445-54ng7m92	307	13	adipogenesis	adipogenesis	NN
cord-262445-54ng7m92	307	14	.	.	.
cord-262445-54ng7m92	308	1	By	by	IN
cord-262445-54ng7m92	308	2	combining	combine	VBG
cord-262445-54ng7m92	308	3	computational	computational	JJ
cord-262445-54ng7m92	308	4	strategies	strategy	NNS
cord-262445-54ng7m92	308	5	based	base	VBN
cord-262445-54ng7m92	308	6	on	on	IN
cord-262445-54ng7m92	308	7	the	the	DT
cord-262445-54ng7m92	308	8	interrogation	interrogation	NN
cord-262445-54ng7m92	308	9	of	of	IN
cord-262445-54ng7m92	308	10	single	single	JJ
cord-262445-54ng7m92	308	11	-	-	HYPH
cord-262445-54ng7m92	308	12	cell	cell	NN
cord-262445-54ng7m92	308	13	transcriptomes	transcriptome	NNS
cord-262445-54ng7m92	308	14	,	,	,
cord-262445-54ng7m92	308	15	in	in	IN
cord-262445-54ng7m92	308	16	silico	silico	NN
cord-262445-54ng7m92	308	17	network	network	NN
cord-262445-54ng7m92	308	18	modeling	modeling	NN
cord-262445-54ng7m92	308	19	and	and	CC
cord-262445-54ng7m92	308	20	RNAseq	RNAseq	NNP
cord-262445-54ng7m92	308	21	data	data	NN
cord-262445-54ng7m92	308	22	integration	integration	NN
cord-262445-54ng7m92	308	23	,	,	,
cord-262445-54ng7m92	308	24	we	-PRON-	PRP
cord-262445-54ng7m92	308	25	conclude	conclude	VBP
cord-262445-54ng7m92	308	26	that	that	DT
cord-262445-54ng7m92	308	27	:	:	:
cord-262445-54ng7m92	308	28	i	i	LS
cord-262445-54ng7m92	308	29	)	)	-RRB-
cord-262445-54ng7m92	308	30	FAPs	FAPs	NNP
cord-262445-54ng7m92	308	31	are	be	VBP
cord-262445-54ng7m92	308	32	the	the	DT
cord-262445-54ng7m92	308	33	main	main	JJ
cord-262445-54ng7m92	308	34	source	source	NN
cord-262445-54ng7m92	308	35	of	of	IN
cord-262445-54ng7m92	308	36	Wnt	Wnt	NNP
cord-262445-54ng7m92	308	37	ligands	ligand	NNS
cord-262445-54ng7m92	308	38	in	in	IN
cord-262445-54ng7m92	308	39	the	the	DT
cord-262445-54ng7m92	308	40	muscle	muscle	NN
cord-262445-54ng7m92	308	41	and	and	CC
cord-262445-54ng7m92	308	42	that	that	IN
cord-262445-54ng7m92	308	43	the	the	DT
cord-262445-54ng7m92	308	44	release	release	NN
cord-262445-54ng7m92	308	45	of	of	IN
cord-262445-54ng7m92	308	46	these	these	DT
cord-262445-54ng7m92	308	47	cytokines	cytokine	NNS
cord-262445-54ng7m92	308	48	may	may	MD
cord-262445-54ng7m92	308	49	trigger	trigger	VB
cord-262445-54ng7m92	308	50	autocrine	autocrine	NN
cord-262445-54ng7m92	308	51	/	/	SYM
cord-262445-54ng7m92	308	52	paracrine	paracrine	JJ
cord-262445-54ng7m92	308	53	responses	response	NNS
cord-262445-54ng7m92	308	54	;	;	:
cord-262445-54ng7m92	308	55	ii	ii	LS
cord-262445-54ng7m92	308	56	)	)	-RRB-
cord-262445-54ng7m92	308	57	the	the	DT
cord-262445-54ng7m92	308	58	Wnt	Wnt	NNP
cord-262445-54ng7m92	308	59	pathway	pathway	NN
cord-262445-54ng7m92	308	60	has	have	VBZ
cord-262445-54ng7m92	308	61	a	a	DT
cord-262445-54ng7m92	308	62	dominant	dominant	JJ
cord-262445-54ng7m92	308	63	role	role	NN
cord-262445-54ng7m92	308	64	in	in	IN
cord-262445-54ng7m92	308	65	regulating	regulate	VBG
cord-262445-54ng7m92	308	66	the	the	DT
cord-262445-54ng7m92	308	67	adipogenic	adipogenic	JJ
cord-262445-54ng7m92	308	68	network	network	NN
cord-262445-54ng7m92	308	69	of	of	IN
cord-262445-54ng7m92	308	70	FAPs	FAPs	NNP
cord-262445-54ng7m92	308	71	;	;	:
cord-262445-54ng7m92	308	72	iii	iii	LS
cord-262445-54ng7m92	308	73	)	)	-RRB-
cord-262445-54ng7m92	309	1	Wnt5a	Wnt5a	NNP
cord-262445-54ng7m92	309	2	expression	expression	NN
cord-262445-54ng7m92	309	3	is	be	VBZ
cord-262445-54ng7m92	309	4	impaired	impair	VBN
cord-262445-54ng7m92	309	5	in	in	IN
cord-262445-54ng7m92	309	6	FAPs	fap	NNS
cord-262445-54ng7m92	309	7	from	from	IN
cord-262445-54ng7m92	309	8	dystrophic	dystrophic	JJ
cord-262445-54ng7m92	309	9	mice	mouse	NNS
cord-262445-54ng7m92	309	10	.	.	.
cord-262445-54ng7m92	310	1	Finally	finally	RB
cord-262445-54ng7m92	310	2	,	,	,
cord-262445-54ng7m92	310	3	we	-PRON-	PRP
cord-262445-54ng7m92	310	4	show	show	VBP
cord-262445-54ng7m92	310	5	that	that	IN
cord-262445-54ng7m92	310	6	exogenous	exogenous	JJ
cord-262445-54ng7m92	310	7	treatment	treatment	NN
cord-262445-54ng7m92	310	8	of	of	IN
cord-262445-54ng7m92	310	9	dystrophic	dystrophic	JJ
cord-262445-54ng7m92	310	10	FAPs	fap	NNS
cord-262445-54ng7m92	310	11	with	with	IN
cord-262445-54ng7m92	310	12	Wnt5a	Wnt5a	NNP
cord-262445-54ng7m92	310	13	is	be	VBZ
cord-262445-54ng7m92	310	14	sufficient	sufficient	JJ
cord-262445-54ng7m92	310	15	to	to	TO
cord-262445-54ng7m92	310	16	repress	repress	VB
cord-262445-54ng7m92	310	17	PPAR	PPAR	NNP
cord-262445-54ng7m92	310	18	expression	expression	NN
cord-262445-54ng7m92	310	19	and	and	CC
cord-262445-54ng7m92	310	20	the	the	DT
cord-262445-54ng7m92	310	21	adipogenic	adipogenic	JJ
cord-262445-54ng7m92	310	22	conversion	conversion	NN
cord-262445-54ng7m92	310	23	of	of	IN
cord-262445-54ng7m92	310	24	FAPs	FAPs	NNP
cord-262445-54ng7m92	310	25	into	into	IN
cord-262445-54ng7m92	310	26	adipocytes	adipocyte	NNS
cord-262445-54ng7m92	310	27	.	.	.
cord-262445-54ng7m92	311	1	These	these	DT
cord-262445-54ng7m92	311	2	results	result	NNS
cord-262445-54ng7m92	311	3	suggest	suggest	VBP
cord-262445-54ng7m92	311	4	that	that	IN
cord-262445-54ng7m92	311	5	by	by	IN
cord-262445-54ng7m92	311	6	modulating	modulate	VBG
cord-262445-54ng7m92	311	7	the	the	DT
cord-262445-54ng7m92	311	8	Wnt	Wnt	NNP
cord-262445-54ng7m92	311	9	pathway	pathway	NN
cord-262445-54ng7m92	311	10	either	either	CC
cord-262445-54ng7m92	311	11	by	by	IN
cord-262445-54ng7m92	311	12	targeting	target	VBG
cord-262445-54ng7m92	311	13	GSK3	GSK3	NNP
cord-262445-54ng7m92	311	14	or	or	CC
cord-262445-54ng7m92	311	15	by	by	IN
cord-262445-54ng7m92	311	16	restoring	restore	VBG
cord-262445-54ng7m92	311	17	autocrine	autocrine	NN
cord-262445-54ng7m92	311	18	Wnt5a	Wnt5a	NNP
cord-262445-54ng7m92	311	19	signaling	signal	VBG
cord-262445-54ng7m92	311	20	in	in	IN
cord-262445-54ng7m92	311	21	FAPs	fap	NNS
cord-262445-54ng7m92	311	22	might	may	MD
cord-262445-54ng7m92	311	23	be	be	VB
cord-262445-54ng7m92	311	24	a	a	DT
cord-262445-54ng7m92	311	25	strategy	strategy	NN
cord-262445-54ng7m92	311	26	to	to	TO
cord-262445-54ng7m92	311	27	counteract	counteract	VB
cord-262445-54ng7m92	311	28	intramuscular	intramuscular	JJ
cord-262445-54ng7m92	311	29	fat	fat	JJ
cord-262445-54ng7m92	311	30	infiltrations	infiltration	NNS
cord-262445-54ng7m92	311	31	in	in	IN
cord-262445-54ng7m92	311	32	myopathies	myopathy	NNS
cord-262445-54ng7m92	311	33	.	.	.
cord-262445-54ng7m92	312	1	In	in	IN
cord-262445-54ng7m92	312	2	skeletal	skeletal	JJ
cord-262445-54ng7m92	312	3	muscle	muscle	NN
cord-262445-54ng7m92	312	4	,	,	,
cord-262445-54ng7m92	312	5	mitochondrial	mitochondrial	NN
cord-262445-54ng7m92	313	1	Ca	ca	NN
cord-262445-54ng7m92	313	2	2	2	CD
cord-262445-54ng7m92	313	3	+	+	CC
cord-262445-54ng7m92	313	4	uptake	uptake	NN
cord-262445-54ng7m92	313	5	plays	play	VBZ
cord-262445-54ng7m92	313	6	important	important	JJ
cord-262445-54ng7m92	313	7	roles	role	NNS
cord-262445-54ng7m92	313	8	in	in	IN
cord-262445-54ng7m92	313	9	organ	organ	NN
cord-262445-54ng7m92	313	10	homeostasis	homeostasis	NN
cord-262445-54ng7m92	313	11	,	,	,
cord-262445-54ng7m92	313	12	ranging	range	VBG
cord-262445-54ng7m92	313	13	from	from	IN
cord-262445-54ng7m92	313	14	control	control	NN
cord-262445-54ng7m92	313	15	of	of	IN
cord-262445-54ng7m92	313	16	metabolism	metabolism	NN
cord-262445-54ng7m92	313	17	to	to	IN
cord-262445-54ng7m92	313	18	regulation	regulation	NN
cord-262445-54ng7m92	313	19	of	of	IN
cord-262445-54ng7m92	313	20	fiber	fiber	NN
cord-262445-54ng7m92	313	21	trophism	trophism	NN
cord-262445-54ng7m92	313	22	.	.	.
cord-262445-54ng7m92	314	1	Still	still	RB
cord-262445-54ng7m92	314	2	debated	debate	VBN
cord-262445-54ng7m92	314	3	is	be	VBZ
cord-262445-54ng7m92	314	4	whether	whether	IN
cord-262445-54ng7m92	314	5	in	in	IN
cord-262445-54ng7m92	314	6	muscle	muscle	NN
cord-262445-54ng7m92	314	7	mitochondria	mitochondrion	NNS
cord-262445-54ng7m92	314	8	can	can	MD
cord-262445-54ng7m92	314	9	buffer	buffer	VB
cord-262445-54ng7m92	314	10	cytosolic	cytosolic	JJ
cord-262445-54ng7m92	314	11	Ca	Ca	NNP
cord-262445-54ng7m92	314	12	2	2	CD
cord-262445-54ng7m92	314	13	+	+	SYM
cord-262445-54ng7m92	314	14	increases	increase	NNS
cord-262445-54ng7m92	314	15	.	.	.
cord-262445-54ng7m92	315	1	To	to	TO
cord-262445-54ng7m92	315	2	answer	answer	VB
cord-262445-54ng7m92	315	3	to	to	IN
cord-262445-54ng7m92	315	4	this	this	DT
cord-262445-54ng7m92	315	5	question	question	NN
cord-262445-54ng7m92	315	6	,	,	,
cord-262445-54ng7m92	315	7	we	-PRON-	PRP
cord-262445-54ng7m92	315	8	explored	explore	VBD
cord-262445-54ng7m92	315	9	the	the	DT
cord-262445-54ng7m92	315	10	effect	effect	NN
cord-262445-54ng7m92	315	11	of	of	IN
cord-262445-54ng7m92	315	12	removing	remove	VBG
cord-262445-54ng7m92	315	13	parvalbumin	parvalbumin	FW
cord-262445-54ng7m92	315	14	(	(	-LRB-
cord-262445-54ng7m92	315	15	PV	PV	NNP
cord-262445-54ng7m92	315	16	)	)	-RRB-
cord-262445-54ng7m92	315	17	,	,	,
cord-262445-54ng7m92	315	18	the	the	DT
cord-262445-54ng7m92	315	19	most	most	RBS
cord-262445-54ng7m92	315	20	important	important	JJ
cord-262445-54ng7m92	315	21	muscle	muscle	NN
cord-262445-54ng7m92	315	22	cytosolic	cytosolic	JJ
cord-262445-54ng7m92	316	1	Ca	ca	NN
cord-262445-54ng7m92	316	2	2	2	CD
cord-262445-54ng7m92	316	3	+	+	CC
cord-262445-54ng7m92	316	4	buffer	buffer	NN
cord-262445-54ng7m92	316	5	.	.	.
cord-262445-54ng7m92	317	1	By	by	IN
cord-262445-54ng7m92	317	2	using	use	VBG
cord-262445-54ng7m92	317	3	a	a	DT
cord-262445-54ng7m92	317	4	PV	pv	NN
cord-262445-54ng7m92	317	5	knockout	knockout	NN
cord-262445-54ng7m92	317	6	(	(	-LRB-
cord-262445-54ng7m92	317	7	KO	KO	NNP
cord-262445-54ng7m92	317	8	)	)	-RRB-
cord-262445-54ng7m92	317	9	mouse	mouse	NN
cord-262445-54ng7m92	317	10	model	model	NN
cord-262445-54ng7m92	317	11	,	,	,
cord-262445-54ng7m92	317	12	we	-PRON-	PRP
cord-262445-54ng7m92	317	13	are	be	VBP
cord-262445-54ng7m92	317	14	investigating	investigate	VBG
cord-262445-54ng7m92	317	15	whether	whether	IN
cord-262445-54ng7m92	317	16	the	the	DT
cord-262445-54ng7m92	317	17	absence	absence	NN
cord-262445-54ng7m92	317	18	of	of	IN
cord-262445-54ng7m92	317	19	PV	PV	NNP
cord-262445-54ng7m92	317	20	induces	induce	VBZ
cord-262445-54ng7m92	317	21	compensatory	compensatory	JJ
cord-262445-54ng7m92	317	22	mechanisms	mechanism	NNS
cord-262445-54ng7m92	317	23	on	on	IN
cord-262445-54ng7m92	317	24	the	the	DT
cord-262445-54ng7m92	317	25	expression	expression	NN
cord-262445-54ng7m92	317	26	and	and	CC
cord-262445-54ng7m92	317	27	function	function	NN
cord-262445-54ng7m92	317	28	of	of	IN
cord-262445-54ng7m92	317	29	the	the	DT
cord-262445-54ng7m92	317	30	mitochondrial	mitochondrial	NN
cord-262445-54ng7m92	318	1	Ca	ca	NN
cord-262445-54ng7m92	318	2	2	2	CD
cord-262445-54ng7m92	318	3	+	+	CC
cord-262445-54ng7m92	318	4	uptake	uptake	NN
cord-262445-54ng7m92	318	5	machinery	machinery	NN
cord-262445-54ng7m92	318	6	(	(	-LRB-
cord-262445-54ng7m92	318	7	MCU	MCU	NNP
cord-262445-54ng7m92	318	8	)	)	-RRB-
cord-262445-54ng7m92	318	9	.	.	.
cord-262445-54ng7m92	319	1	The	the	DT
cord-262445-54ng7m92	319	2	data	datum	NNS
cord-262445-54ng7m92	319	3	obtained	obtain	VBN
cord-262445-54ng7m92	319	4	so	so	RB
cord-262445-54ng7m92	319	5	far	far	RB
cord-262445-54ng7m92	319	6	confirm	confirm	VB
cord-262445-54ng7m92	319	7	that	that	IN
cord-262445-54ng7m92	319	8	the	the	DT
cord-262445-54ng7m92	319	9	absence	absence	NN
cord-262445-54ng7m92	319	10	of	of	IN
cord-262445-54ng7m92	319	11	PV	PV	NNP
cord-262445-54ng7m92	319	12	induces	induce	VBZ
cord-262445-54ng7m92	319	13	an	an	DT
cord-262445-54ng7m92	319	14	increase	increase	NN
cord-262445-54ng7m92	319	15	of	of	IN
cord-262445-54ng7m92	319	16	mitochondrial	mitochondrial	NN
cord-262445-54ng7m92	320	1	Ca	ca	NN
cord-262445-54ng7m92	320	2	2	2	CD
cord-262445-54ng7m92	320	3	+	+	CC
cord-262445-54ng7m92	320	4	uptake	uptake	NN
cord-262445-54ng7m92	320	5	and	and	CC
cord-262445-54ng7m92	320	6	this	this	DT
cord-262445-54ng7m92	320	7	is	be	VBZ
cord-262445-54ng7m92	320	8	accompanied	accompany	VBN
cord-262445-54ng7m92	320	9	by	by	IN
cord-262445-54ng7m92	320	10	the	the	DT
cord-262445-54ng7m92	320	11	induction	induction	NN
cord-262445-54ng7m92	320	12	of	of	IN
cord-262445-54ng7m92	320	13	the	the	DT
cord-262445-54ng7m92	320	14	expression	expression	NN
cord-262445-54ng7m92	320	15	of	of	IN
cord-262445-54ng7m92	320	16	the	the	DT
cord-262445-54ng7m92	320	17	MCU	MCU	NNP
cord-262445-54ng7m92	320	18	coin	coin	NN
cord-262445-54ng7m92	320	19	vitromplex	vitromplex	NN
cord-262445-54ng7m92	320	20	components	component	NNS
cord-262445-54ng7m92	320	21	.	.	.
cord-262445-54ng7m92	321	1	Moreover	moreover	RB
cord-262445-54ng7m92	321	2	,	,	,
cord-262445-54ng7m92	321	3	electron	electron	NN
cord-262445-54ng7m92	321	4	microscopy	microscopy	NN
cord-262445-54ng7m92	321	5	analysis	analysis	NN
cord-262445-54ng7m92	321	6	performed	perform	VBN
cord-262445-54ng7m92	321	7	on	on	IN
cord-262445-54ng7m92	321	8	extensor	extensor	FW
cord-262445-54ng7m92	321	9	digitorum	digitorum	NNP
cord-262445-54ng7m92	321	10	longus	longus	NN
cord-262445-54ng7m92	321	11	(	(	-LRB-
cord-262445-54ng7m92	321	12	EDL	EDL	NNP
cord-262445-54ng7m92	321	13	)	)	-RRB-
cord-262445-54ng7m92	321	14	muscle	muscle	NN
cord-262445-54ng7m92	321	15	of	of	IN
cord-262445-54ng7m92	321	16	WT	WT	NNP
cord-262445-54ng7m92	321	17	and	and	CC
cord-262445-54ng7m92	321	18	PV	PV	NNP
cord-262445-54ng7m92	321	19	KO	KO	NNP
cord-262445-54ng7m92	321	20	mice	mouse	NNS
cord-262445-54ng7m92	321	21	,	,	,
cord-262445-54ng7m92	321	22	demonstrated	demonstrate	VBD
cord-262445-54ng7m92	321	23	that	that	IN
cord-262445-54ng7m92	321	24	PV	PV	NNP
cord-262445-54ng7m92	321	25	KO	KO	NNP
cord-262445-54ng7m92	321	26	mitochondria	mitochondrion	NNS
cord-262445-54ng7m92	321	27	are	be	VBP
cord-262445-54ng7m92	321	28	significantly	significantly	RB
cord-262445-54ng7m92	321	29	larger	large	JJR
cord-262445-54ng7m92	321	30	than	than	IN
cord-262445-54ng7m92	321	31	WT	WT	NNP
cord-262445-54ng7m92	321	32	controls	control	NNS
cord-262445-54ng7m92	321	33	and	and	CC
cord-262445-54ng7m92	321	34	with	with	IN
cord-262445-54ng7m92	321	35	a	a	DT
cord-262445-54ng7m92	321	36	different	different	JJ
cord-262445-54ng7m92	321	37	redistribution	redistribution	NN
cord-262445-54ng7m92	321	38	in	in	IN
cord-262445-54ng7m92	321	39	the	the	DT
cord-262445-54ng7m92	321	40	muscular	muscular	JJ
cord-262445-54ng7m92	321	41	tissue	tissue	NN
cord-262445-54ng7m92	321	42	,	,	,
cord-262445-54ng7m92	321	43	suggesting	suggest	VBG
cord-262445-54ng7m92	321	44	a	a	DT
cord-262445-54ng7m92	321	45	strict	strict	JJ
cord-262445-54ng7m92	321	46	connection	connection	NN
cord-262445-54ng7m92	321	47	and	and	CC
cord-262445-54ng7m92	321	48	regulation	regulation	NN
cord-262445-54ng7m92	321	49	between	between	IN
cord-262445-54ng7m92	321	50	PV	pv	NN
cord-262445-54ng7m92	321	51	expression	expression	NN
cord-262445-54ng7m92	321	52	and	and	CC
cord-262445-54ng7m92	321	53	mitochondrial	mitochondrial	JJ
cord-262445-54ng7m92	321	54	morphology	morphology	NN
cord-262445-54ng7m92	321	55	and	and	CC
cord-262445-54ng7m92	321	56	function	function	NN
cord-262445-54ng7m92	321	57	in	in	IN
cord-262445-54ng7m92	321	58	muscle	muscle	NN
cord-262445-54ng7m92	321	59	cells	cell	NNS
cord-262445-54ng7m92	321	60	.	.	.
cord-262445-54ng7m92	322	1	Furthermore	furthermore	RB
cord-262445-54ng7m92	322	2	,	,	,
cord-262445-54ng7m92	322	3	cytosolic	cytosolic	JJ
cord-262445-54ng7m92	322	4	Ca	Ca	NNP
cord-262445-54ng7m92	322	5	2	2	CD
cord-262445-54ng7m92	322	6	+	+	SYM
cord-262445-54ng7m92	322	7	transients	transient	NNS
cord-262445-54ng7m92	322	8	in	in	IN
cord-262445-54ng7m92	322	9	PV	PV	NNP
cord-262445-54ng7m92	322	10	KO	KO	NNP
cord-262445-54ng7m92	322	11	muscle	muscle	NN
cord-262445-54ng7m92	322	12	fibers	fiber	NNS
cord-262445-54ng7m92	322	13	show	show	VBP
cord-262445-54ng7m92	322	14	that	that	IN
cord-262445-54ng7m92	322	15	the	the	DT
cord-262445-54ng7m92	322	16	time	time	NN
cord-262445-54ng7m92	322	17	to	to	TO
cord-262445-54ng7m92	322	18	reach	reach	VB
cord-262445-54ng7m92	322	19	the	the	DT
cord-262445-54ng7m92	322	20	peak	peak	NN
cord-262445-54ng7m92	322	21	upon	upon	IN
cord-262445-54ng7m92	322	22	stimulation	stimulation	NN
cord-262445-54ng7m92	322	23	and	and	CC
cord-262445-54ng7m92	322	24	the	the	DT
cord-262445-54ng7m92	322	25	time	time	NN
cord-262445-54ng7m92	322	26	to	to	IN
cord-262445-54ng7m92	322	27	half	half	JJ
cord-262445-54ng7m92	322	28	relaxation	relaxation	NN
cord-262445-54ng7m92	322	29	are	be	VBP
cord-262445-54ng7m92	322	30	prolonged	prolong	VBN
cord-262445-54ng7m92	322	31	in	in	IN
cord-262445-54ng7m92	322	32	PV	PV	NNP
cord-262445-54ng7m92	322	33	KO	KO	NNP
cord-262445-54ng7m92	322	34	muscles	muscle	NNS
cord-262445-54ng7m92	322	35	.	.	.
cord-262445-54ng7m92	323	1	To	to	TO
cord-262445-54ng7m92	323	2	verify	verify	VB
cord-262445-54ng7m92	323	3	whether	whether	IN
cord-262445-54ng7m92	323	4	the	the	DT
cord-262445-54ng7m92	323	5	increase	increase	NN
cord-262445-54ng7m92	323	6	of	of	IN
cord-262445-54ng7m92	323	7	mitochondrial	mitochondrial	NN
cord-262445-54ng7m92	324	1	Ca	ca	NN
cord-262445-54ng7m92	324	2	2	2	CD
cord-262445-54ng7m92	324	3	+	+	CC
cord-262445-54ng7m92	324	4	uptake	uptake	NN
cord-262445-54ng7m92	324	5	in	in	IN
cord-262445-54ng7m92	324	6	KO	KO	NNP
cord-262445-54ng7m92	324	7	fibers	fiber	NNS
cord-262445-54ng7m92	324	8	is	be	VBZ
cord-262445-54ng7m92	324	9	due	due	JJ
cord-262445-54ng7m92	324	10	to	to	IN
cord-262445-54ng7m92	324	11	mitochondrial	mitochondrial	JJ
cord-262445-54ng7m92	324	12	adaptation	adaptation	NN
cord-262445-54ng7m92	324	13	and	and	CC
cord-262445-54ng7m92	324	14	whether	whether	IN
cord-262445-54ng7m92	324	15	MCU	MCU	NNP
cord-262445-54ng7m92	324	16	is	be	VBZ
cord-262445-54ng7m92	324	17	responsible	responsible	JJ
cord-262445-54ng7m92	324	18	of	of	IN
cord-262445-54ng7m92	324	19	buffering	buffer	VBG
cord-262445-54ng7m92	324	20	cytosolic	cytosolic	JJ
cord-262445-54ng7m92	325	1	Ca	ca	NN
cord-262445-54ng7m92	325	2	2	2	CD
cord-262445-54ng7m92	325	3	+	+	CC
cord-262445-54ng7m92	325	4	increase	increase	NN
cord-262445-54ng7m92	325	5	,	,	,
cord-262445-54ng7m92	325	6	we	-PRON-	PRP
cord-262445-54ng7m92	325	7	decided	decide	VBD
cord-262445-54ng7m92	325	8	to	to	IN
cord-262445-54ng7m92	325	9	silencing	silence	VBG
cord-262445-54ng7m92	325	10	MCU	MCU	NNP
cord-262445-54ng7m92	325	11	and	and	CC
cord-262445-54ng7m92	325	12	measure	measure	VB
cord-262445-54ng7m92	325	13	[	[	-LRB-
cord-262445-54ng7m92	326	1	Ca	ca	NN
cord-262445-54ng7m92	326	2	2	2	CD
cord-262445-54ng7m92	326	3	+	+	SYM
cord-262445-54ng7m92	326	4	]	]	-RRB-
cord-262445-54ng7m92	326	5	cyt	cyt	NN
cord-262445-54ng7m92	326	6	on	on	IN
cord-262445-54ng7m92	326	7	FDB	FDB	NNP
cord-262445-54ng7m92	326	8	muscles	muscle	NNS
cord-262445-54ng7m92	326	9	of	of	IN
cord-262445-54ng7m92	326	10	WT	WT	NNP
cord-262445-54ng7m92	326	11	and	and	CC
cord-262445-54ng7m92	326	12	PV	PV	NNP
cord-262445-54ng7m92	326	13	KO	KO	NNP
cord-262445-54ng7m92	326	14	animals	animal	NNS
cord-262445-54ng7m92	326	15	.	.	.
cord-262445-54ng7m92	327	1	[	[	-LRB-
cord-262445-54ng7m92	327	2	Ca	Ca	NNP
cord-262445-54ng7m92	327	3	2	2	CD
cord-262445-54ng7m92	327	4	+	+	SYM
cord-262445-54ng7m92	327	5	]	]	-RRB-
cord-262445-54ng7m92	327	6	cyt	cyt	NN
cord-262445-54ng7m92	327	7	was	be	VBD
cord-262445-54ng7m92	327	8	almost	almost	RB
cord-262445-54ng7m92	327	9	unaffected	unaffected	JJ
cord-262445-54ng7m92	327	10	by	by	IN
cord-262445-54ng7m92	327	11	the	the	DT
cord-262445-54ng7m92	327	12	absence	absence	NN
cord-262445-54ng7m92	327	13	of	of	IN
cord-262445-54ng7m92	327	14	MCU	MCU	NNP
cord-262445-54ng7m92	327	15	in	in	IN
cord-262445-54ng7m92	327	16	WT	WT	NNP
cord-262445-54ng7m92	327	17	animals	animal	NNS
cord-262445-54ng7m92	327	18	while	while	IN
cord-262445-54ng7m92	327	19	,	,	,
cord-262445-54ng7m92	327	20	in	in	IN
cord-262445-54ng7m92	327	21	PV	PV	NNP
cord-262445-54ng7m92	327	22	KO	KO	NNP
cord-262445-54ng7m92	327	23	fibers	fiber	NNS
cord-262445-54ng7m92	327	24	,	,	,
cord-262445-54ng7m92	327	25	[	[	-LRB-
cord-262445-54ng7m92	327	26	Ca	Ca	NNP
cord-262445-54ng7m92	327	27	2	2	CD
cord-262445-54ng7m92	327	28	+	+	SYM
cord-262445-54ng7m92	327	29	]	]	-RRB-
cord-262445-54ng7m92	327	30	cyt	cyt	NN
cord-262445-54ng7m92	327	31	was	be	VBD
cord-262445-54ng7m92	327	32	significantly	significantly	RB
cord-262445-54ng7m92	327	33	higher	high	JJR
cord-262445-54ng7m92	327	34	upon	upon	IN
cord-262445-54ng7m92	327	35	stimulation	stimulation	NN
cord-262445-54ng7m92	327	36	.	.	.
cord-262445-54ng7m92	328	1	Furthermore	furthermore	RB
cord-262445-54ng7m92	328	2	,	,	,
cord-262445-54ng7m92	328	3	since	since	IN
cord-262445-54ng7m92	328	4	PV	PV	NNP
cord-262445-54ng7m92	328	5	is	be	VBZ
cord-262445-54ng7m92	328	6	one	one	CD
cord-262445-54ng7m92	328	7	of	of	IN
cord-262445-54ng7m92	328	8	the	the	DT
cord-262445-54ng7m92	328	9	most	most	RBS
cord-262445-54ng7m92	328	10	downregulated	downregulated	JJ
cord-262445-54ng7m92	328	11	atrogenes	atrogene	NNS
cord-262445-54ng7m92	328	12	,	,	,
cord-262445-54ng7m92	328	13	the	the	DT
cord-262445-54ng7m92	328	14	genes	gene	NNS
cord-262445-54ng7m92	328	15	commonly	commonly	RB
cord-262445-54ng7m92	328	16	up	up	IN
cord-262445-54ng7m92	328	17	-	-	HYPH
cord-262445-54ng7m92	328	18	and	and	CC
cord-262445-54ng7m92	328	19	down	down	RB
cord-262445-54ng7m92	328	20	-	-	HYPH
cord-262445-54ng7m92	328	21	regulated	regulate	VBN
cord-262445-54ng7m92	328	22	during	during	IN
cord-262445-54ng7m92	328	23	several	several	JJ
cord-262445-54ng7m92	328	24	types	type	NNS
cord-262445-54ng7m92	328	25	of	of	IN
cord-262445-54ng7m92	328	26	atrophy	atrophy	NN
cord-262445-54ng7m92	328	27	,	,	,
cord-262445-54ng7m92	328	28	and	and	CC
cord-262445-54ng7m92	328	29	that	that	DT
cord-262445-54ng7m92	328	30	mitochondrial	mitochondrial	NN
cord-262445-54ng7m92	329	1	Ca	ca	NN
cord-262445-54ng7m92	329	2	2	2	CD
cord-262445-54ng7m92	329	3	+	+	SYM
cord-262445-54ng7m92	329	4	controls	control	NNS
cord-262445-54ng7m92	329	5	skeletal	skeletal	JJ
cord-262445-54ng7m92	329	6	muscle	muscle	NN
cord-262445-54ng7m92	329	7	trophism	trophism	NN
cord-262445-54ng7m92	329	8	,	,	,
cord-262445-54ng7m92	329	9	we	-PRON-	PRP
cord-262445-54ng7m92	329	10	decided	decide	VBD
cord-262445-54ng7m92	329	11	to	to	TO
cord-262445-54ng7m92	329	12	study	study	VB
cord-262445-54ng7m92	329	13	the	the	DT
cord-262445-54ng7m92	329	14	role	role	NN
cord-262445-54ng7m92	329	15	of	of	IN
cord-262445-54ng7m92	329	16	PV	PV	NNP
cord-262445-54ng7m92	329	17	on	on	IN
cord-262445-54ng7m92	329	18	muscle	muscle	NN
cord-262445-54ng7m92	329	19	mass	mass	NN
cord-262445-54ng7m92	329	20	through	through	IN
cord-262445-54ng7m92	329	21	denervation	denervation	NN
cord-262445-54ng7m92	329	22	experiments	experiment	NNS
cord-262445-54ng7m92	329	23	.	.	.
cord-262445-54ng7m92	330	1	When	when	WRB
cord-262445-54ng7m92	330	2	PV	PV	NNP
cord-262445-54ng7m92	330	3	is	be	VBZ
cord-262445-54ng7m92	330	4	absent	absent	JJ
cord-262445-54ng7m92	330	5	,	,	,
cord-262445-54ng7m92	330	6	loss	loss	NN
cord-262445-54ng7m92	330	7	of	of	IN
cord-262445-54ng7m92	330	8	muscle	muscle	NN
cord-262445-54ng7m92	330	9	mass	mass	NN
cord-262445-54ng7m92	330	10	is	be	VBZ
cord-262445-54ng7m92	330	11	reduced	reduce	VBN
cord-262445-54ng7m92	330	12	compared	compare	VBN
cord-262445-54ng7m92	330	13	to	to	IN
cord-262445-54ng7m92	330	14	WT	wt	NN
cord-262445-54ng7m92	330	15	fibers	fiber	NNS
cord-262445-54ng7m92	330	16	,	,	,
cord-262445-54ng7m92	330	17	demonstrating	demonstrate	VBG
cord-262445-54ng7m92	330	18	that	that	IN
cord-262445-54ng7m92	330	19	PV	pv	NN
cord-262445-54ng7m92	330	20	can	can	MD
cord-262445-54ng7m92	330	21	partially	partially	RB
cord-262445-54ng7m92	330	22	protect	protect	VB
cord-262445-54ng7m92	330	23	muscles	muscle	NNS
cord-262445-54ng7m92	330	24	from	from	IN
cord-262445-54ng7m92	330	25	denervation	denervation	NN
cord-262445-54ng7m92	330	26	-	-	HYPH
cord-262445-54ng7m92	330	27	induced	induce	VBN
cord-262445-54ng7m92	330	28	atrophy	atrophy	NN
cord-262445-54ng7m92	330	29	.	.	.
cord-262445-54ng7m92	331	1	Overall	overall	RB
cord-262445-54ng7m92	331	2	,	,	,
cord-262445-54ng7m92	331	3	our	-PRON-	PRP$
cord-262445-54ng7m92	331	4	results	result	NNS
cord-262445-54ng7m92	331	5	indicate	indicate	VBP
cord-262445-54ng7m92	331	6	that	that	IN
cord-262445-54ng7m92	331	7	PV	PV	NNP
cord-262445-54ng7m92	331	8	plays	play	VBZ
cord-262445-54ng7m92	331	9	an	an	DT
cord-262445-54ng7m92	331	10	important	important	JJ
cord-262445-54ng7m92	331	11	role	role	NN
cord-262445-54ng7m92	331	12	in	in	IN
cord-262445-54ng7m92	331	13	spatiotemporal	spatiotemporal	JJ
cord-262445-54ng7m92	331	14	control	control	NN
cord-262445-54ng7m92	331	15	of	of	IN
cord-262445-54ng7m92	331	16	cytosolic	cytosolic	JJ
cord-262445-54ng7m92	331	17	Ca	Ca	NNP
cord-262445-54ng7m92	331	18	2	2	CD
cord-262445-54ng7m92	332	1	+	+	CC
cord-262445-54ng7m92	332	2	responses	response	NNS
cord-262445-54ng7m92	332	3	on	on	IN
cord-262445-54ng7m92	332	4	mitochondrial	mitochondrial	NN
cord-262445-54ng7m92	333	1	Ca	ca	NN
cord-262445-54ng7m92	333	2	2	2	CD
cord-262445-54ng7m92	333	3	+	+	CC
cord-262445-54ng7m92	333	4	uptake	uptake	NN
cord-262445-54ng7m92	333	5	and	and	CC
cord-262445-54ng7m92	333	6	have	have	VB
cord-262445-54ng7m92	333	7	a	a	DT
cord-262445-54ng7m92	333	8	profound	profound	JJ
cord-262445-54ng7m92	333	9	impact	impact	NN
cord-262445-54ng7m92	333	10	on	on	IN
cord-262445-54ng7m92	333	11	skeletal	skeletal	JJ
cord-262445-54ng7m92	333	12	muscle	muscle	NN
cord-262445-54ng7m92	333	13	trophism	trophism	NN
cord-262445-54ng7m92	333	14	.	.	.
cord-262445-54ng7m92	334	1	The	the	DT
cord-262445-54ng7m92	334	2	second	second	JJ
cord-262445-54ng7m92	334	3	messenger	messenger	NN
cord-262445-54ng7m92	335	1	Ca	ca	NN
cord-262445-54ng7m92	335	2	2	2	CD
cord-262445-54ng7m92	335	3	+	+	SYM
cord-262445-54ng7m92	335	4	regulates	regulate	VBZ
cord-262445-54ng7m92	335	5	a	a	DT
cord-262445-54ng7m92	335	6	broad	broad	JJ
cord-262445-54ng7m92	335	7	repertoire	repertoire	NN
cord-262445-54ng7m92	335	8	of	of	IN
cord-262445-54ng7m92	335	9	cellular	cellular	JJ
cord-262445-54ng7m92	335	10	processes	process	NNS
cord-262445-54ng7m92	335	11	.	.	.
cord-262445-54ng7m92	336	1	Upon	upon	IN
cord-262445-54ng7m92	336	2	physiological	physiological	JJ
cord-262445-54ng7m92	336	3	stimuli	stimulus	NNS
cord-262445-54ng7m92	336	4	,	,	,
cord-262445-54ng7m92	336	5	skeletal	skeletal	JJ
cord-262445-54ng7m92	336	6	muscle	muscle	NN
cord-262445-54ng7m92	336	7	mitochondria	mitochondrion	NNS
cord-262445-54ng7m92	336	8	rapidly	rapidly	RB
cord-262445-54ng7m92	336	9	and	and	CC
cord-262445-54ng7m92	336	10	efficiently	efficiently	RB
cord-262445-54ng7m92	336	11	accumulate	accumulate	VB
cord-262445-54ng7m92	337	1	Ca	ca	NN
cord-262445-54ng7m92	337	2	2	2	CD
cord-262445-54ng7m92	337	3	+	+	CC
cord-262445-54ng7m92	337	4	into	into	IN
cord-262445-54ng7m92	337	5	their	-PRON-	PRP$
cord-262445-54ng7m92	337	6	matrix	matrix	NN
cord-262445-54ng7m92	337	7	via	via	IN
cord-262445-54ng7m92	337	8	an	an	DT
cord-262445-54ng7m92	337	9	electrogenic	electrogenic	JJ
cord-262445-54ng7m92	337	10	pathway	pathway	NN
cord-262445-54ng7m92	337	11	,	,	,
cord-262445-54ng7m92	337	12	that	that	WDT
cord-262445-54ng7m92	337	13	relies	rely	VBZ
cord-262445-54ng7m92	337	14	on	on	IN
cord-262445-54ng7m92	337	15	the	the	DT
cord-262445-54ng7m92	337	16	driving	drive	VBG
cord-262445-54ng7m92	337	17	force	force	NN
cord-262445-54ng7m92	337	18	of	of	IN
cord-262445-54ng7m92	337	19	a	a	DT
cord-262445-54ng7m92	337	20	steep	steep	JJ
cord-262445-54ng7m92	337	21	electrochemical	electrochemical	JJ
cord-262445-54ng7m92	337	22	gradient	gradient	NN
cord-262445-54ng7m92	337	23	.	.	.
cord-262445-54ng7m92	338	1	A	a	DT
cord-262445-54ng7m92	338	2	large	large	JJ
cord-262445-54ng7m92	338	3	[	[	-LRB-
cord-262445-54ng7m92	339	1	Ca	ca	NN
cord-262445-54ng7m92	339	2	2	2	CD
cord-262445-54ng7m92	339	3	+	+	CD
cord-262445-54ng7m92	339	4	]	]	-RRB-
cord-262445-54ng7m92	340	1	mt	mt	NNP
cord-262445-54ng7m92	340	2	peak	peak	NN
cord-262445-54ng7m92	340	3	occurs	occur	VBZ
cord-262445-54ng7m92	340	4	dynamically	dynamically	RB
cord-262445-54ng7m92	340	5	in	in	IN
cord-262445-54ng7m92	340	6	parallel	parallel	NN
cord-262445-54ng7m92	340	7	to	to	IN
cord-262445-54ng7m92	340	8	agonist	agonist	NN
cord-262445-54ng7m92	340	9	-	-	HYPH
cord-262445-54ng7m92	340	10	induced	induce	VBN
cord-262445-54ng7m92	340	11	[	[	-LRB-
cord-262445-54ng7m92	340	12	Ca	Ca	NNP
cord-262445-54ng7m92	340	13	2	2	CD
cord-262445-54ng7m92	340	14	+	+	SYM
cord-262445-54ng7m92	340	15	]	]	-RRB-
cord-262445-54ng7m92	340	16	cyt	cyt	NN
cord-262445-54ng7m92	340	17	increases	increase	NNS
cord-262445-54ng7m92	340	18	,	,	,
cord-262445-54ng7m92	340	19	thanks	thank	NNS
cord-262445-54ng7m92	340	20	to	to	IN
cord-262445-54ng7m92	340	21	the	the	DT
cord-262445-54ng7m92	340	22	activity	activity	NN
cord-262445-54ng7m92	340	23	of	of	IN
cord-262445-54ng7m92	340	24	the	the	DT
cord-262445-54ng7m92	340	25	Mitochondrial	Mitochondrial	NNP
cord-262445-54ng7m92	340	26	Calcium	Calcium	NNP
cord-262445-54ng7m92	340	27	Uniporter	Uniporter	NNP
cord-262445-54ng7m92	340	28	(	(	-LRB-
cord-262445-54ng7m92	340	29	MCU	MCU	NNP
cord-262445-54ng7m92	340	30	)	)	-RRB-
cord-262445-54ng7m92	340	31	,	,	,
cord-262445-54ng7m92	340	32	the	the	DT
cord-262445-54ng7m92	340	33	highly	highly	RB
cord-262445-54ng7m92	340	34	selective	selective	JJ
cord-262445-54ng7m92	340	35	channel	channel	NN
cord-262445-54ng7m92	340	36	responsible	responsible	JJ
cord-262445-54ng7m92	340	37	for	for	IN
cord-262445-54ng7m92	340	38	mitochondrial	mitochondrial	NN
cord-262445-54ng7m92	341	1	Ca	ca	NN
cord-262445-54ng7m92	341	2	2	2	CD
cord-262445-54ng7m92	341	3	+	+	CC
cord-262445-54ng7m92	341	4	accumulation	accumulation	NN
cord-262445-54ng7m92	341	5	.	.	.
cord-262445-54ng7m92	342	1	MCU	MCU	NNP
cord-262445-54ng7m92	342	2	positively	positively	RB
cord-262445-54ng7m92	342	3	regulates	regulate	VBZ
cord-262445-54ng7m92	342	4	myofiber	myofiber	NN
cord-262445-54ng7m92	342	5	size	size	NN
cord-262445-54ng7m92	342	6	in	in	IN
cord-262445-54ng7m92	342	7	physiological	physiological	JJ
cord-262445-54ng7m92	342	8	conditions	condition	NNS
cord-262445-54ng7m92	342	9	,	,	,
cord-262445-54ng7m92	342	10	and	and	CC
cord-262445-54ng7m92	342	11	counteracts	counteract	VBZ
cord-262445-54ng7m92	342	12	pathological	pathological	JJ
cord-262445-54ng7m92	342	13	loss	loss	NN
cord-262445-54ng7m92	342	14	of	of	IN
cord-262445-54ng7m92	342	15	muscle	muscle	NN
cord-262445-54ng7m92	342	16	mass	mass	NN
cord-262445-54ng7m92	342	17	.	.	.
cord-262445-54ng7m92	343	1	We	-PRON-	PRP
cord-262445-54ng7m92	343	2	have	have	VBP
cord-262445-54ng7m92	343	3	previously	previously	RB
cord-262445-54ng7m92	343	4	demonstrated	demonstrate	VBN
cord-262445-54ng7m92	343	5	that	that	IN
cord-262445-54ng7m92	343	6	skeletal	skeletal	JJ
cord-262445-54ng7m92	343	7	muscle	muscle	NN
cord-262445-54ng7m92	343	8	-	-	HYPH
cord-262445-54ng7m92	343	9	specific	specific	JJ
cord-262445-54ng7m92	343	10	MCU	MCU	NNP
cord-262445-54ng7m92	343	11	deletion	deletion	NN
cord-262445-54ng7m92	343	12	(	(	-LRB-
cord-262445-54ng7m92	343	13	MCU	MCU	NNP
cord-262445-54ng7m92	343	14	-/-	-/-	NNP
cord-262445-54ng7m92	343	15	)	)	-RRB-
cord-262445-54ng7m92	343	16	inhibits	inhibit	VBZ
cord-262445-54ng7m92	343	17	myofiber	myofiber	NN
cord-262445-54ng7m92	343	18	mitochondrial	mitochondrial	NN
cord-262445-54ng7m92	344	1	Ca	ca	NN
cord-262445-54ng7m92	344	2	2	2	CD
cord-262445-54ng7m92	344	3	+	+	CC
cord-262445-54ng7m92	344	4	uptake	uptake	NN
cord-262445-54ng7m92	344	5	,	,	,
cord-262445-54ng7m92	344	6	impairs	impair	VBZ
cord-262445-54ng7m92	344	7	muscle	muscle	NN
cord-262445-54ng7m92	344	8	force	force	NN
cord-262445-54ng7m92	344	9	and	and	CC
cord-262445-54ng7m92	344	10	exercise	exercise	NN
cord-262445-54ng7m92	344	11	performance	performance	NN
cord-262445-54ng7m92	344	12	.	.	.
cord-262445-54ng7m92	345	1	Mitochondrial	mitochondrial	NN
cord-262445-54ng7m92	346	1	Ca	ca	NN
cord-262445-54ng7m92	346	2	2	2	CD
cord-262445-54ng7m92	346	3	+	+	CC
cord-262445-54ng7m92	346	4	uptake	uptake	NN
cord-262445-54ng7m92	346	5	is	be	VBZ
cord-262445-54ng7m92	346	6	required	require	VBN
cord-262445-54ng7m92	346	7	for	for	IN
cord-262445-54ng7m92	346	8	effective	effective	JJ
cord-262445-54ng7m92	346	9	glucose	glucose	NN
cord-262445-54ng7m92	346	10	oxidation	oxidation	NN
cord-262445-54ng7m92	346	11	and	and	CC
cord-262445-54ng7m92	346	12	efficient	efficient	JJ
cord-262445-54ng7m92	346	13	mitochondrial	mitochondrial	JJ
cord-262445-54ng7m92	346	14	activity	activity	NN
cord-262445-54ng7m92	346	15	.	.	.
cord-262445-54ng7m92	347	1	Nonetheless	nonetheless	RB
cord-262445-54ng7m92	347	2	in	in	IN
cord-262445-54ng7m92	347	3	MCU	MCU	NNP
cord-262445-54ng7m92	347	4	-/myofibres	-/myofibres	NNP
cord-262445-54ng7m92	347	5	,	,	,
cord-262445-54ng7m92	347	6	impaired	impaired	JJ
cord-262445-54ng7m92	347	7	oxidative	oxidative	JJ
cord-262445-54ng7m92	347	8	capacity	capacity	NN
cord-262445-54ng7m92	347	9	is	be	VBZ
cord-262445-54ng7m92	347	10	partially	partially	RB
cord-262445-54ng7m92	347	11	sustained	sustain	VBN
cord-262445-54ng7m92	347	12	by	by	IN
cord-262445-54ng7m92	347	13	increased	increase	VBN
cord-262445-54ng7m92	347	14	fatty	fatty	JJ
cord-262445-54ng7m92	347	15	acid	acid	NN
cord-262445-54ng7m92	347	16	(	(	-LRB-
cord-262445-54ng7m92	347	17	FA	fa	NN
cord-262445-54ng7m92	347	18	)	)	-RRB-
cord-262445-54ng7m92	347	19	oxidation	oxidation	NN
cord-262445-54ng7m92	347	20	.	.	.
cord-262445-54ng7m92	348	1	The	the	DT
cord-262445-54ng7m92	348	2	main	main	JJ
cord-262445-54ng7m92	348	3	trigger	trigger	NN
cord-262445-54ng7m92	348	4	of	of	IN
cord-262445-54ng7m92	348	5	this	this	DT
cord-262445-54ng7m92	348	6	metabolic	metabolic	JJ
cord-262445-54ng7m92	348	7	rewiring	rewiring	NN
cord-262445-54ng7m92	348	8	is	be	VBZ
cord-262445-54ng7m92	348	9	the	the	DT
cord-262445-54ng7m92	348	10	decreased	decrease	VBN
cord-262445-54ng7m92	348	11	pyruvate	pyruvate	NN
cord-262445-54ng7m92	348	12	dehydrogenase	dehydrogenase	NN
cord-262445-54ng7m92	348	13	activity	activity	NN
cord-262445-54ng7m92	348	14	which	which	WDT
cord-262445-54ng7m92	348	15	is	be	VBZ
cord-262445-54ng7m92	348	16	tightly	tightly	RB
cord-262445-54ng7m92	348	17	controlled	control	VBN
cord-262445-54ng7m92	348	18	by	by	IN
cord-262445-54ng7m92	348	19	mitochondrial	mitochondrial	NN
cord-262445-54ng7m92	349	1	Ca	ca	NN
cord-262445-54ng7m92	349	2	2	2	CD
cord-262445-54ng7m92	349	3	+	+	CC
cord-262445-54ng7m92	349	4	accumulation	accumulation	NN
cord-262445-54ng7m92	349	5	.	.	.
cord-262445-54ng7m92	350	1	Here	here	RB
cord-262445-54ng7m92	350	2	,	,	,
cord-262445-54ng7m92	350	3	we	-PRON-	PRP
cord-262445-54ng7m92	350	4	have	have	VBP
cord-262445-54ng7m92	350	5	investigated	investigate	VBN
cord-262445-54ng7m92	350	6	the	the	DT
cord-262445-54ng7m92	350	7	role	role	NN
cord-262445-54ng7m92	350	8	of	of	IN
cord-262445-54ng7m92	350	9	mitochondrial	mitochondrial	NN
cord-262445-54ng7m92	351	1	Ca	ca	NN
cord-262445-54ng7m92	351	2	2	2	CD
cord-262445-54ng7m92	351	3	+	+	CC
cord-262445-54ng7m92	351	4	uptake	uptake	NN
cord-262445-54ng7m92	351	5	during	during	IN
cord-262445-54ng7m92	351	6	skeletal	skeletal	JJ
cord-262445-54ng7m92	351	7	muscle	muscle	NN
cord-262445-54ng7m92	351	8	aging	aging	NN
cord-262445-54ng7m92	351	9	.	.	.
cord-262445-54ng7m92	352	1	In	in	IN
cord-262445-54ng7m92	352	2	detail	detail	NN
cord-262445-54ng7m92	352	3	,	,	,
cord-262445-54ng7m92	352	4	we	-PRON-	PRP
cord-262445-54ng7m92	352	5	show	show	VBP
cord-262445-54ng7m92	352	6	that	that	IN
cord-262445-54ng7m92	352	7	mitochondrial	mitochondrial	NN
cord-262445-54ng7m92	353	1	Ca	ca	NN
cord-262445-54ng7m92	353	2	2	2	CD
cord-262445-54ng7m92	353	3	+	+	CC
cord-262445-54ng7m92	353	4	accumulation	accumulation	NN
cord-262445-54ng7m92	353	5	is	be	VBZ
cord-262445-54ng7m92	353	6	decreased	decrease	VBN
cord-262445-54ng7m92	353	7	in	in	IN
cord-262445-54ng7m92	353	8	24	24	CD
cord-262445-54ng7m92	353	9	months	month	NNS
cord-262445-54ng7m92	353	10	old	old	JJ
cord-262445-54ng7m92	353	11	mice	mouse	NNS
cord-262445-54ng7m92	353	12	and	and	CC
cord-262445-54ng7m92	353	13	this	this	DT
cord-262445-54ng7m92	353	14	condition	condition	NN
cord-262445-54ng7m92	353	15	is	be	VBZ
cord-262445-54ng7m92	353	16	accompanied	accompany	VBN
cord-262445-54ng7m92	353	17	by	by	IN
cord-262445-54ng7m92	353	18	a	a	DT
cord-262445-54ng7m92	353	19	decreased	decrease	VBN
cord-262445-54ng7m92	353	20	pyruvate	pyruvate	NN
cord-262445-54ng7m92	353	21	dehydrogenase	dehydrogenase	NN
cord-262445-54ng7m92	353	22	activity	activity	NN
cord-262445-54ng7m92	353	23	.	.	.
cord-262445-54ng7m92	354	1	In	in	IN
cord-262445-54ng7m92	354	2	this	this	DT
cord-262445-54ng7m92	354	3	scenario	scenario	NN
cord-262445-54ng7m92	354	4	we	-PRON-	PRP
cord-262445-54ng7m92	354	5	demonstrate	demonstrate	VBP
cord-262445-54ng7m92	354	6	a	a	DT
cord-262445-54ng7m92	354	7	rewiring	rewiring	NN
cord-262445-54ng7m92	354	8	of	of	IN
cord-262445-54ng7m92	354	9	skeletal	skeletal	JJ
cord-262445-54ng7m92	354	10	muscle	muscle	NN
cord-262445-54ng7m92	354	11	metabolism	metabolism	NN
cord-262445-54ng7m92	354	12	where	where	WRB
cord-262445-54ng7m92	354	13	mitochondrial	mitochondrial	JJ
cord-262445-54ng7m92	354	14	activity	activity	NN
cord-262445-54ng7m92	354	15	is	be	VBZ
cord-262445-54ng7m92	354	16	sustained	sustain	VBN
cord-262445-54ng7m92	354	17	by	by	IN
cord-262445-54ng7m92	354	18	FA	FA	NNP
cord-262445-54ng7m92	354	19	oxidation	oxidation	NN
cord-262445-54ng7m92	354	20	rather	rather	RB
cord-262445-54ng7m92	354	21	than	than	IN
cord-262445-54ng7m92	354	22	glucose	glucose	NN
cord-262445-54ng7m92	354	23	.	.	.
cord-262445-54ng7m92	355	1	Further	further	JJ
cord-262445-54ng7m92	355	2	studies	study	NNS
cord-262445-54ng7m92	355	3	are	be	VBP
cord-262445-54ng7m92	355	4	needed	need	VBN
cord-262445-54ng7m92	355	5	to	to	TO
cord-262445-54ng7m92	355	6	evaluate	evaluate	VB
cord-262445-54ng7m92	355	7	whether	whether	IN
cord-262445-54ng7m92	355	8	the	the	DT
cord-262445-54ng7m92	355	9	restore	restore	NN
cord-262445-54ng7m92	355	10	of	of	IN
cord-262445-54ng7m92	355	11	glucose	glucose	NN
cord-262445-54ng7m92	355	12	as	as	IN
cord-262445-54ng7m92	355	13	the	the	DT
cord-262445-54ng7m92	355	14	main	main	JJ
cord-262445-54ng7m92	355	15	fuel	fuel	NN
cord-262445-54ng7m92	355	16	for	for	IN
cord-262445-54ng7m92	355	17	oxidative	oxidative	JJ
cord-262445-54ng7m92	355	18	metabolism	metabolism	NN
cord-262445-54ng7m92	355	19	will	will	MD
cord-262445-54ng7m92	355	20	be	be	VB
cord-262445-54ng7m92	355	21	sufficient	sufficient	JJ
cord-262445-54ng7m92	355	22	to	to	IN
cord-262445-54ng7m92	355	23	counteracting	counteract	VBG
cord-262445-54ng7m92	355	24	aging	aging	NN
cord-262445-54ng7m92	355	25	process	process	NN
cord-262445-54ng7m92	355	26	,	,	,
cord-262445-54ng7m92	355	27	including	include	VBG
cord-262445-54ng7m92	355	28	force	force	NN
cord-262445-54ng7m92	355	29	and	and	CC
cord-262445-54ng7m92	355	30	performance	performance	NN
cord-262445-54ng7m92	355	31	,	,	,
cord-262445-54ng7m92	355	32	in	in	IN
cord-262445-54ng7m92	355	33	skeletal	skeletal	JJ
cord-262445-54ng7m92	355	34	muscles	muscle	NNS
cord-262445-54ng7m92	355	35	.	.	.
cord-262445-54ng7m92	356	1	Dystrophin	dystrophin	JJ
cord-262445-54ng7m92	356	2	deficiency	deficiency	NN
cord-262445-54ng7m92	356	3	causes	cause	VBZ
cord-262445-54ng7m92	356	4	chronic	chronic	JJ
cord-262445-54ng7m92	356	5	wasting	wasting	NN
cord-262445-54ng7m92	356	6	of	of	IN
cord-262445-54ng7m92	356	7	the	the	DT
cord-262445-54ng7m92	356	8	skeletal	skeletal	JJ
cord-262445-54ng7m92	356	9	muscle	muscle	NN
cord-262445-54ng7m92	356	10	tissue	tissue	NN
cord-262445-54ng7m92	356	11	leading	lead	VBG
cord-262445-54ng7m92	356	12	to	to	IN
cord-262445-54ng7m92	356	13	patient	patient	JJ
cord-262445-54ng7m92	356	14	respiratory	respiratory	NN
cord-262445-54ng7m92	356	15	or	or	CC
cord-262445-54ng7m92	356	16	heart	heart	NN
cord-262445-54ng7m92	356	17	failure	failure	NN
cord-262445-54ng7m92	356	18	and	and	CC
cord-262445-54ng7m92	356	19	,	,	,
cord-262445-54ng7m92	356	20	finally	finally	RB
cord-262445-54ng7m92	356	21	,	,	,
cord-262445-54ng7m92	356	22	death	death	NN
cord-262445-54ng7m92	356	23	.	.	.
cord-262445-54ng7m92	357	1	In	in	IN
cord-262445-54ng7m92	357	2	addition	addition	NN
cord-262445-54ng7m92	357	3	to	to	IN
cord-262445-54ng7m92	357	4	fiber	fiber	NN
cord-262445-54ng7m92	357	5	fragility	fragility	NN
cord-262445-54ng7m92	357	6	,	,	,
cord-262445-54ng7m92	357	7	the	the	DT
cord-262445-54ng7m92	357	8	absence	absence	NN
cord-262445-54ng7m92	357	9	of	of	IN
cord-262445-54ng7m92	357	10	the	the	DT
cord-262445-54ng7m92	357	11	dystrophin	dystrophin	NN
cord-262445-54ng7m92	357	12	protein	protein	NN
cord-262445-54ng7m92	357	13	,	,	,
cord-262445-54ng7m92	357	14	as	as	IN
cord-262445-54ng7m92	357	15	in	in	IN
cord-262445-54ng7m92	357	16	Duchenne	Duchenne	NNP
cord-262445-54ng7m92	357	17	Muscular	Muscular	NNP
cord-262445-54ng7m92	357	18	Dystrophy	Dystrophy	NNP
cord-262445-54ng7m92	357	19	(	(	-LRB-
cord-262445-54ng7m92	357	20	DMD	DMD	NNP
cord-262445-54ng7m92	357	21	)	)	-RRB-
cord-262445-54ng7m92	357	22	,	,	,
cord-262445-54ng7m92	357	23	causes	cause	VBZ
cord-262445-54ng7m92	357	24	a	a	DT
cord-262445-54ng7m92	357	25	variety	variety	NN
cord-262445-54ng7m92	357	26	of	of	IN
cord-262445-54ng7m92	357	27	poorly	poorly	RB
cord-262445-54ng7m92	357	28	understood	understand	VBN
cord-262445-54ng7m92	357	29	secondary	secondary	JJ
cord-262445-54ng7m92	357	30	effects	effect	NNS
cord-262445-54ng7m92	357	31	.	.	.
cord-262445-54ng7m92	358	1	Notably	notably	IN
cord-262445-54ng7m92	358	2	muscle	muscle	NN
cord-262445-54ng7m92	358	3	fibers	fiber	NNS
cord-262445-54ng7m92	358	4	of	of	IN
cord-262445-54ng7m92	358	5	dystrophic	dystrophic	JJ
cord-262445-54ng7m92	358	6	individuals	individual	NNS
cord-262445-54ng7m92	358	7	are	be	VBP
cord-262445-54ng7m92	358	8	characterized	characterize	VBN
cord-262445-54ng7m92	358	9	by	by	IN
cord-262445-54ng7m92	358	10	mitochondrial	mitochondrial	JJ
cord-262445-54ng7m92	358	11	dysfunctions	dysfunction	NNS
cord-262445-54ng7m92	358	12	,	,	,
cord-262445-54ng7m92	358	13	as	as	IN
cord-262445-54ng7m92	358	14	revealed	reveal	VBN
cord-262445-54ng7m92	358	15	by	by	IN
cord-262445-54ng7m92	358	16	a	a	DT
cord-262445-54ng7m92	358	17	reduced	reduce	VBN
cord-262445-54ng7m92	358	18	ATP	ATP	NNP
cord-262445-54ng7m92	358	19	production	production	NN
cord-262445-54ng7m92	358	20	rate	rate	NN
cord-262445-54ng7m92	358	21	and	and	CC
cord-262445-54ng7m92	358	22	by	by	IN
cord-262445-54ng7m92	358	23	defective	defective	JJ
cord-262445-54ng7m92	358	24	oxidative	oxidative	JJ
cord-262445-54ng7m92	358	25	phosphorylation	phosphorylation	NN
cord-262445-54ng7m92	358	26	(	(	-LRB-
cord-262445-54ng7m92	358	27	OxPhos	OxPhos	NNP
cord-262445-54ng7m92	358	28	)	)	-RRB-
cord-262445-54ng7m92	358	29	.	.	.
cord-262445-54ng7m92	359	1	We	-PRON-	PRP
cord-262445-54ng7m92	359	2	recently	recently	RB
cord-262445-54ng7m92	359	3	discovered	discover	VBD
cord-262445-54ng7m92	359	4	that	that	IN
cord-262445-54ng7m92	359	5	in	in	IN
cord-262445-54ng7m92	359	6	a	a	DT
cord-262445-54ng7m92	359	7	mouse	mouse	NN
cord-262445-54ng7m92	359	8	model	model	NN
cord-262445-54ng7m92	359	9	of	of	IN
cord-262445-54ng7m92	359	10	DMD	DMD	NNP
cord-262445-54ng7m92	359	11	(	(	-LRB-
cord-262445-54ng7m92	359	12	mdx	mdx	NNP
cord-262445-54ng7m92	359	13	)	)	-RRB-
cord-262445-54ng7m92	359	14	,	,	,
cord-262445-54ng7m92	359	15	the	the	DT
cord-262445-54ng7m92	359	16	interstitial	interstitial	JJ
cord-262445-54ng7m92	359	17	Fibro	Fibro	NNP
cord-262445-54ng7m92	359	18	/	/	SYM
cord-262445-54ng7m92	359	19	Adipogenic	Adipogenic	NNP
cord-262445-54ng7m92	359	20	Progenitor	Progenitor	NNP
cord-262445-54ng7m92	359	21	(	(	-LRB-
cord-262445-54ng7m92	359	22	FAP	FAP	NNP
cord-262445-54ng7m92	359	23	)	)	-RRB-
cord-262445-54ng7m92	359	24	cells	cell	NNS
cord-262445-54ng7m92	359	25	are	be	VBP
cord-262445-54ng7m92	359	26	also	also	RB
cord-262445-54ng7m92	359	27	characterized	characterize	VBN
cord-262445-54ng7m92	359	28	by	by	IN
cord-262445-54ng7m92	359	29	a	a	DT
cord-262445-54ng7m92	359	30	dysfunctional	dysfunctional	JJ
cord-262445-54ng7m92	359	31	mitochondrial	mitochondrial	JJ
cord-262445-54ng7m92	359	32	metabolism	metabolism	NN
cord-262445-54ng7m92	359	33	which	which	WDT
cord-262445-54ng7m92	359	34	correlates	correlate	VBZ
cord-262445-54ng7m92	359	35	with	with	IN
cord-262445-54ng7m92	359	36	an	an	DT
cord-262445-54ng7m92	359	37	increased	increase	VBN
cord-262445-54ng7m92	359	38	adipogenic	adipogenic	JJ
cord-262445-54ng7m92	359	39	differentiation	differentiation	NN
cord-262445-54ng7m92	359	40	potential	potential	NN
cord-262445-54ng7m92	359	41	.	.	.
cord-262445-54ng7m92	360	1	Using	use	VBG
cord-262445-54ng7m92	360	2	high	high	JJ
cord-262445-54ng7m92	360	3	-	-	HYPH
cord-262445-54ng7m92	360	4	sensitivity	sensitivity	NN
cord-262445-54ng7m92	360	5	mass	mass	NN
cord-262445-54ng7m92	360	6	spectrometry	spectrometry	NN
cord-262445-54ng7m92	360	7	-	-	HYPH
cord-262445-54ng7m92	360	8	based	base	VBN
cord-262445-54ng7m92	360	9	proteomics	proteomic	NNS
cord-262445-54ng7m92	360	10	,	,	,
cord-262445-54ng7m92	360	11	we	-PRON-	PRP
cord-262445-54ng7m92	360	12	highlighted	highlight	VBD
cord-262445-54ng7m92	360	13	that	that	IN
cord-262445-54ng7m92	360	14	a	a	DT
cord-262445-54ng7m92	360	15	short	short	JJ
cord-262445-54ng7m92	360	16	-	-	HYPH
cord-262445-54ng7m92	360	17	term	term	NN
cord-262445-54ng7m92	360	18	high	high	JJ
cord-262445-54ng7m92	360	19	-	-	HYPH
cord-262445-54ng7m92	360	20	fat	fat	NN
cord-262445-54ng7m92	360	21	diet	diet	NN
cord-262445-54ng7m92	360	22	regimen	regimen	NN
cord-262445-54ng7m92	360	23	reprograms	reprogram	VBZ
cord-262445-54ng7m92	360	24	dystrophic	dystrophic	NNP
cord-262445-54ng7m92	360	25	FAP	FAP	NNP
cord-262445-54ng7m92	360	26	metabolism	metabolism	NN
cord-262445-54ng7m92	360	27	in	in	IN
cord-262445-54ng7m92	360	28	vivo	vivo	NN
cord-262445-54ng7m92	360	29	.	.	.
cord-262445-54ng7m92	361	1	By	by	IN
cord-262445-54ng7m92	361	2	combining	combine	VBG
cord-262445-54ng7m92	361	3	our	-PRON-	PRP$
cord-262445-54ng7m92	361	4	proteomic	proteomic	JJ
cord-262445-54ng7m92	361	5	dataset	dataset	NN
cord-262445-54ng7m92	361	6	with	with	IN
cord-262445-54ng7m92	361	7	a	a	DT
cord-262445-54ng7m92	361	8	literature	literature	NN
cord-262445-54ng7m92	361	9	-	-	HYPH
cord-262445-54ng7m92	361	10	derived	derive	VBN
cord-262445-54ng7m92	361	11	signaling	signal	VBG
cord-262445-54ng7m92	361	12	network	network	NN
cord-262445-54ng7m92	361	13	,	,	,
cord-262445-54ng7m92	361	14	we	-PRON-	PRP
cord-262445-54ng7m92	361	15	discovered	discover	VBD
cord-262445-54ng7m92	361	16	a	a	DT
cord-262445-54ng7m92	361	17	high	high	JJ
cord-262445-54ng7m92	361	18	-	-	HYPH
cord-262445-54ng7m92	361	19	fat	fat	NN
cord-262445-54ng7m92	361	20	dependent	dependent	JJ
cord-262445-54ng7m92	361	21	modulation	modulation	NN
cord-262445-54ng7m92	361	22	of	of	IN
cord-262445-54ng7m92	361	23	the	the	DT
cord-262445-54ng7m92	361	24	crucial	crucial	JJ
cord-262445-54ng7m92	361	25	hub	hub	NN
cord-262445-54ng7m92	361	26	protein	protein	NN
cord-262445-54ng7m92	361	27	,	,	,
cord-262445-54ng7m92	361	28	-catenin	-catenin	CD
cord-262445-54ng7m92	361	29	,	,	,
cord-262445-54ng7m92	361	30	which	which	WDT
cord-262445-54ng7m92	361	31	controls	control	VBZ
cord-262445-54ng7m92	361	32	follistatin	follistatin	NNP
cord-262445-54ng7m92	361	33	expression	expression	NN
cord-262445-54ng7m92	361	34	.	.	.
cord-262445-54ng7m92	362	1	Our	-PRON-	PRP$
cord-262445-54ng7m92	362	2	results	result	NNS
cord-262445-54ng7m92	362	3	reveal	reveal	VBP
cord-262445-54ng7m92	362	4	that	that	IN
cord-262445-54ng7m92	362	5	a	a	DT
cord-262445-54ng7m92	362	6	short	short	JJ
cord-262445-54ng7m92	362	7	-	-	HYPH
cord-262445-54ng7m92	362	8	term	term	NN
cord-262445-54ng7m92	362	9	highfat	highfat	JJ
cord-262445-54ng7m92	362	10	diet	diet	NN
cord-262445-54ng7m92	362	11	restores	restore	VBZ
cord-262445-54ng7m92	362	12	the	the	DT
cord-262445-54ng7m92	362	13	key	key	JJ
cord-262445-54ng7m92	362	14	role	role	NN
cord-262445-54ng7m92	362	15	of	of	IN
cord-262445-54ng7m92	362	16	FAPs	FAPs	NNP
cord-262445-54ng7m92	362	17	in	in	IN
cord-262445-54ng7m92	362	18	enhancing	enhance	VBG
cord-262445-54ng7m92	362	19	the	the	DT
cord-262445-54ng7m92	362	20	myogenic	myogenic	NNP
cord-262445-54ng7m92	362	21	activity	activity	NN
cord-262445-54ng7m92	362	22	of	of	IN
cord-262445-54ng7m92	362	23	the	the	DT
cord-262445-54ng7m92	362	24	skeletal	skeletal	JJ
cord-262445-54ng7m92	362	25	muscle	muscle	NN
cord-262445-54ng7m92	362	26	stem	stem	NN
cord-262445-54ng7m92	362	27	cells	cell	NNS
cord-262445-54ng7m92	362	28	in	in	IN
cord-262445-54ng7m92	362	29	dystrophic	dystrophic	JJ
cord-262445-54ng7m92	362	30	mice	mouse	NNS
cord-262445-54ng7m92	362	31	.	.	.
cord-262445-54ng7m92	363	1	Consistently	consistently	RB
cord-262445-54ng7m92	363	2	,	,	,
cord-262445-54ng7m92	363	3	we	-PRON-	PRP
cord-262445-54ng7m92	363	4	observe	observe	VBP
cord-262445-54ng7m92	363	5	that	that	IN
cord-262445-54ng7m92	363	6	muscle	muscle	NN
cord-262445-54ng7m92	363	7	regeneration	regeneration	NN
cord-262445-54ng7m92	363	8	in	in	IN
cord-262445-54ng7m92	363	9	the	the	DT
cord-262445-54ng7m92	363	10	mdx	mdx	NNP
cord-262445-54ng7m92	363	11	mouse	mouse	NN
cord-262445-54ng7m92	363	12	is	be	VBZ
cord-262445-54ng7m92	363	13	significantly	significantly	RB
cord-262445-54ng7m92	363	14	improved	improve	VBN
cord-262445-54ng7m92	363	15	by	by	IN
cord-262445-54ng7m92	363	16	the	the	DT
cord-262445-54ng7m92	363	17	short	short	JJ
cord-262445-54ng7m92	363	18	-	-	HYPH
cord-262445-54ng7m92	363	19	term	term	NN
cord-262445-54ng7m92	363	20	high	high	JJ
cord-262445-54ng7m92	363	21	-	-	HYPH
cord-262445-54ng7m92	363	22	fat	fat	NN
cord-262445-54ng7m92	363	23	diet	diet	NN
cord-262445-54ng7m92	363	24	.	.	.
cord-262445-54ng7m92	364	1	Our	-PRON-	PRP$
cord-262445-54ng7m92	364	2	results	result	NNS
cord-262445-54ng7m92	364	3	support	support	VBP
cord-262445-54ng7m92	364	4	metabolic	metabolic	JJ
cord-262445-54ng7m92	364	5	reprogramming	reprogramming	NN
cord-262445-54ng7m92	364	6	of	of	IN
cord-262445-54ng7m92	364	7	muscle	muscle	NN
cord-262445-54ng7m92	364	8	interstitial	interstitial	JJ
cord-262445-54ng7m92	364	9	progenitor	progenitor	NN
cord-262445-54ng7m92	364	10	cells	cell	NNS
cord-262445-54ng7m92	364	11	as	as	IN
cord-262445-54ng7m92	364	12	a	a	DT
cord-262445-54ng7m92	364	13	novel	novel	JJ
cord-262445-54ng7m92	364	14	approach	approach	NN
cord-262445-54ng7m92	364	15	to	to	TO
cord-262445-54ng7m92	364	16	alleviate	alleviate	VB
cord-262445-54ng7m92	364	17	some	some	DT
cord-262445-54ng7m92	364	18	of	of	IN
cord-262445-54ng7m92	364	19	the	the	DT
cord-262445-54ng7m92	364	20	adverse	adverse	JJ
cord-262445-54ng7m92	364	21	outcomes	outcome	NNS
cord-262445-54ng7m92	364	22	of	of	IN
cord-262445-54ng7m92	364	23	Duchenne	Duchenne	NNP
cord-262445-54ng7m92	364	24	Muscular	Muscular	NNP
cord-262445-54ng7m92	364	25	Dystrophy	Dystrophy	NNP
cord-262445-54ng7m92	364	26	.	.	.
cord-262445-54ng7m92	365	1	If	if	IN
cord-262445-54ng7m92	365	2	we	-PRON-	PRP
cord-262445-54ng7m92	365	3	concentrate	concentrate	VBP
cord-262445-54ng7m92	365	4	Homo	homo	NN
cord-262445-54ng7m92	365	5	sapiens	sapiens	JJ
cord-262445-54ng7m92	365	6	existence	existence	NN
cord-262445-54ng7m92	365	7	in	in	IN
cord-262445-54ng7m92	365	8	just	just	RB
cord-262445-54ng7m92	365	9	24	24	CD
cord-262445-54ng7m92	365	10	hours	hour	NNS
cord-262445-54ng7m92	365	11	,	,	,
cord-262445-54ng7m92	365	12	the	the	DT
cord-262445-54ng7m92	365	13	time	time	NN
cord-262445-54ng7m92	365	14	he	-PRON-	PRP
cord-262445-54ng7m92	365	15	started	start	VBD
cord-262445-54ng7m92	365	16	to	to	TO
cord-262445-54ng7m92	365	17	be	be	VB
cord-262445-54ng7m92	365	18	totally	totally	RB
cord-262445-54ng7m92	365	19	sedentary	sedentary	JJ
cord-262445-54ng7m92	365	20	is	be	VBZ
cord-262445-54ng7m92	365	21	just	just	RB
cord-262445-54ng7m92	365	22	30	30	CD
cord-262445-54ng7m92	365	23	seconds	second	NNS
cord-262445-54ng7m92	365	24	ago	ago	RB
cord-262445-54ng7m92	365	25	,	,	,
cord-262445-54ng7m92	365	26	while	while	IN
cord-262445-54ng7m92	365	27	his	-PRON-	PRP$
cord-262445-54ng7m92	365	28	life	life	NN
cord-262445-54ng7m92	365	29	expectation	expectation	NN
cord-262445-54ng7m92	365	30	exceeded	exceed	VBD
cord-262445-54ng7m92	365	31	the	the	DT
cord-262445-54ng7m92	365	32	60-year	60-year	JJ
cord-262445-54ng7m92	365	33	during	during	IN
cord-262445-54ng7m92	365	34	the	the	DT
cord-262445-54ng7m92	365	35	last	last	JJ
cord-262445-54ng7m92	365	36	25	25	CD
cord-262445-54ng7m92	365	37	seconds	second	NNS
cord-262445-54ng7m92	365	38	.	.	.
cord-262445-54ng7m92	366	1	The	the	DT
cord-262445-54ng7m92	366	2	combination	combination	NN
cord-262445-54ng7m92	366	3	of	of	IN
cord-262445-54ng7m92	366	4	a	a	DT
cord-262445-54ng7m92	366	5	novel	novel	JJ
cord-262445-54ng7m92	366	6	life	life	NN
cord-262445-54ng7m92	366	7	-	-	HYPH
cord-262445-54ng7m92	366	8	style	style	NN
cord-262445-54ng7m92	366	9	with	with	IN
cord-262445-54ng7m92	366	10	an	an	DT
cord-262445-54ng7m92	366	11	increased	increase	VBN
cord-262445-54ng7m92	366	12	life	life	NN
cord-262445-54ng7m92	366	13	-	-	HYPH
cord-262445-54ng7m92	366	14	span	span	NN
cord-262445-54ng7m92	366	15	,	,	,
cord-262445-54ng7m92	366	16	two	two	CD
cord-262445-54ng7m92	366	17	conditions	condition	NNS
cord-262445-54ng7m92	366	18	that	that	WDT
cord-262445-54ng7m92	366	19	our	-PRON-	PRP$
cord-262445-54ng7m92	366	20	species	specie	NNS
cord-262445-54ng7m92	366	21	never	never	RB
cord-262445-54ng7m92	366	22	experienced	experience	VBN
cord-262445-54ng7m92	366	23	before	before	RB
cord-262445-54ng7m92	366	24	,	,	,
cord-262445-54ng7m92	366	25	resulted	result	VBD
cord-262445-54ng7m92	366	26	in	in	IN
cord-262445-54ng7m92	366	27	the	the	DT
cord-262445-54ng7m92	366	28	onset	onset	NN
cord-262445-54ng7m92	366	29	of	of	IN
cord-262445-54ng7m92	366	30	many	many	JJ
cord-262445-54ng7m92	366	31	chronic	chronic	JJ
cord-262445-54ng7m92	366	32	and	and	CC
cord-262445-54ng7m92	366	33	metabolic	metabolic	JJ
cord-262445-54ng7m92	366	34	diseases	disease	NNS
cord-262445-54ng7m92	366	35	.	.	.
cord-262445-54ng7m92	367	1	Nevertheless	nevertheless	RB
cord-262445-54ng7m92	367	2	,	,	,
cord-262445-54ng7m92	367	3	emerging	emerge	VBG
cord-262445-54ng7m92	367	4	evidence	evidence	NN
cord-262445-54ng7m92	367	5	shows	show	VBZ
cord-262445-54ng7m92	367	6	that	that	IN
cord-262445-54ng7m92	367	7	readopting	readopte	VBG
cord-262445-54ng7m92	367	8	a	a	DT
cord-262445-54ng7m92	367	9	"	"	``
cord-262445-54ng7m92	367	10	more	more	RBR
cord-262445-54ng7m92	367	11	active	active	JJ
cord-262445-54ng7m92	367	12	"	"	''
cord-262445-54ng7m92	367	13	life	life	NN
cord-262445-54ng7m92	367	14	-	-	HYPH
cord-262445-54ng7m92	367	15	style	style	NN
cord-262445-54ng7m92	367	16	is	be	VBZ
cord-262445-54ng7m92	367	17	associated	associate	VBN
cord-262445-54ng7m92	367	18	with	with	IN
cord-262445-54ng7m92	367	19	healthier	healthy	JJR
cord-262445-54ng7m92	367	20	and	and	CC
cord-262445-54ng7m92	367	21	longer	long	JJR
cord-262445-54ng7m92	367	22	life	life	NN
cord-262445-54ng7m92	367	23	-	-	HYPH
cord-262445-54ng7m92	367	24	span	span	NN
cord-262445-54ng7m92	367	25	.	.	.
cord-262445-54ng7m92	368	1	Whole	whole	JJ
cord-262445-54ng7m92	368	2	-	-	HYPH
cord-262445-54ng7m92	368	3	body	body	NN
cord-262445-54ng7m92	368	4	beneficial	beneficial	JJ
cord-262445-54ng7m92	368	5	effects	effect	NNS
cord-262445-54ng7m92	368	6	of	of	IN
cord-262445-54ng7m92	368	7	physical	physical	JJ
cord-262445-54ng7m92	368	8	activity	activity	NN
cord-262445-54ng7m92	368	9	are	be	VBP
cord-262445-54ng7m92	368	10	the	the	DT
cord-262445-54ng7m92	368	11	consequence	consequence	NN
cord-262445-54ng7m92	368	12	of	of	IN
cord-262445-54ng7m92	368	13	adaptive	adaptive	JJ
cord-262445-54ng7m92	368	14	metabolic	metabolic	JJ
cord-262445-54ng7m92	368	15	changes	change	NNS
cord-262445-54ng7m92	368	16	established	establish	VBN
cord-262445-54ng7m92	368	17	in	in	IN
cord-262445-54ng7m92	368	18	the	the	DT
cord-262445-54ng7m92	368	19	entire	entire	JJ
cord-262445-54ng7m92	368	20	organism	organism	NN
cord-262445-54ng7m92	368	21	to	to	TO
cord-262445-54ng7m92	368	22	sustain	sustain	VB
cord-262445-54ng7m92	368	23	the	the	DT
cord-262445-54ng7m92	368	24	high	high	JJ
cord-262445-54ng7m92	368	25	energy	energy	NN
cord-262445-54ng7m92	368	26	expenditure	expenditure	NN
cord-262445-54ng7m92	368	27	of	of	IN
cord-262445-54ng7m92	368	28	contracting	contract	VBG
cord-262445-54ng7m92	368	29	skeletal	skeletal	JJ
cord-262445-54ng7m92	368	30	muscles	muscle	NNS
cord-262445-54ng7m92	368	31	.	.	.
cord-262445-54ng7m92	369	1	During	during	IN
cord-262445-54ng7m92	369	2	last	last	JJ
cord-262445-54ng7m92	369	3	years	year	NNS
cord-262445-54ng7m92	369	4	,	,	,
cord-262445-54ng7m92	369	5	many	many	JJ
cord-262445-54ng7m92	369	6	efforts	effort	NNS
cord-262445-54ng7m92	369	7	have	have	VBP
cord-262445-54ng7m92	369	8	been	be	VBN
cord-262445-54ng7m92	369	9	made	make	VBN
cord-262445-54ng7m92	369	10	to	to	TO
cord-262445-54ng7m92	369	11	dissect	dissect	VB
cord-262445-54ng7m92	369	12	the	the	DT
cord-262445-54ng7m92	369	13	molecular	molecular	JJ
cord-262445-54ng7m92	369	14	mechanisms	mechanism	NNS
cord-262445-54ng7m92	369	15	explaining	explain	VBG
cord-262445-54ng7m92	369	16	why	why	WRB
cord-262445-54ng7m92	369	17	physical	physical	JJ
cord-262445-54ng7m92	369	18	activity	activity	NN
cord-262445-54ng7m92	369	19	sustains	sustain	VBZ
cord-262445-54ng7m92	369	20	and	and	CC
cord-262445-54ng7m92	369	21	improves	improve	VBZ
cord-262445-54ng7m92	369	22	life	life	NN
cord-262445-54ng7m92	369	23	quality	quality	NN
cord-262445-54ng7m92	369	24	.	.	.
cord-262445-54ng7m92	370	1	Recently	recently	RB
cord-262445-54ng7m92	370	2	,	,	,
cord-262445-54ng7m92	370	3	our	-PRON-	PRP$
cord-262445-54ng7m92	370	4	group	group	NN
cord-262445-54ng7m92	370	5	identified	identify	VBD
cord-262445-54ng7m92	370	6	the	the	DT
cord-262445-54ng7m92	370	7	Trascription	Trascription	NNP
cord-262445-54ng7m92	370	8	-	-	HYPH
cord-262445-54ng7m92	370	9	Factor	Factor	NNP
cord-262445-54ng7m92	370	10	EB	EB	NNP
cord-262445-54ng7m92	370	11	as	as	IN
cord-262445-54ng7m92	370	12	a	a	DT
cord-262445-54ng7m92	370	13	muscular	muscular	JJ
cord-262445-54ng7m92	370	14	master	master	NN
cord-262445-54ng7m92	370	15	metabolic	metabolic	JJ
cord-262445-54ng7m92	370	16	regulator	regulator	NN
cord-262445-54ng7m92	370	17	that	that	WDT
cord-262445-54ng7m92	370	18	translocates	translocate	VBZ
cord-262445-54ng7m92	370	19	into	into	IN
cord-262445-54ng7m92	370	20	myonuclei	myonuclei	NNP
cord-262445-54ng7m92	370	21	in	in	IN
cord-262445-54ng7m92	370	22	response	response	NN
cord-262445-54ng7m92	370	23	to	to	TO
cord-262445-54ng7m92	370	24	exercise	exercise	VB
cord-262445-54ng7m92	370	25	promoting	promote	VBG
cord-262445-54ng7m92	370	26	the	the	DT
cord-262445-54ng7m92	370	27	expression	expression	NN
cord-262445-54ng7m92	370	28	of	of	IN
cord-262445-54ng7m92	370	29	genes	gene	NNS
cord-262445-54ng7m92	370	30	for	for	IN
cord-262445-54ng7m92	370	31	different	different	JJ
cord-262445-54ng7m92	370	32	fuel	fuel	NN
cord-262445-54ng7m92	370	33	disposal	disposal	NN
cord-262445-54ng7m92	370	34	and	and	CC
cord-262445-54ng7m92	370	35	utilization	utilization	NN
cord-262445-54ng7m92	370	36	.	.	.
cord-262445-54ng7m92	371	1	These	these	DT
cord-262445-54ng7m92	371	2	findings	finding	NNS
cord-262445-54ng7m92	371	3	strongly	strongly	RB
cord-262445-54ng7m92	371	4	support	support	VBP
cord-262445-54ng7m92	371	5	TFEB	TFEB	NNP
cord-262445-54ng7m92	371	6	activity	activity	NN
cord-262445-54ng7m92	371	7	as	as	IN
cord-262445-54ng7m92	371	8	crucial	crucial	JJ
cord-262445-54ng7m92	371	9	for	for	IN
cord-262445-54ng7m92	371	10	the	the	DT
cord-262445-54ng7m92	371	11	beneficial	beneficial	JJ
cord-262445-54ng7m92	371	12	effects	effect	NNS
cord-262445-54ng7m92	371	13	of	of	IN
cord-262445-54ng7m92	371	14	exercise	exercise	NN
cord-262445-54ng7m92	371	15	.	.	.
cord-262445-54ng7m92	372	1	Starting	start	VBG
cord-262445-54ng7m92	372	2	from	from	IN
cord-262445-54ng7m92	372	3	this	this	DT
cord-262445-54ng7m92	372	4	evidence	evidence	NN
cord-262445-54ng7m92	372	5	we	-PRON-	PRP
cord-262445-54ng7m92	372	6	decided	decide	VBD
cord-262445-54ng7m92	372	7	to	to	TO
cord-262445-54ng7m92	372	8	discover	discover	VB
cord-262445-54ng7m92	372	9	new	new	JJ
cord-262445-54ng7m92	372	10	uncharacterized	uncharacterized	JJ
cord-262445-54ng7m92	372	11	genes	gene	NNS
cord-262445-54ng7m92	372	12	that	that	WDT
cord-262445-54ng7m92	372	13	may	may	MD
cord-262445-54ng7m92	372	14	mechanistically	mechanistically	RB
cord-262445-54ng7m92	372	15	explain	explain	VB
cord-262445-54ng7m92	372	16	adaptive	adaptive	JJ
cord-262445-54ng7m92	372	17	effects	effect	NNS
cord-262445-54ng7m92	372	18	of	of	IN
cord-262445-54ng7m92	372	19	TFEB	TFEB	NNP
cord-262445-54ng7m92	372	20	on	on	IN
cord-262445-54ng7m92	372	21	skeletal	skeletal	JJ
cord-262445-54ng7m92	372	22	muscle	muscle	NN
cord-262445-54ng7m92	372	23	.	.	.
cord-262445-54ng7m92	373	1	By	by	IN
cord-262445-54ng7m92	373	2	crossing	cross	VBG
cord-262445-54ng7m92	373	3	gene	gene	NN
cord-262445-54ng7m92	373	4	expression	expression	NN
cord-262445-54ng7m92	373	5	data	datum	NNS
cord-262445-54ng7m92	373	6	of	of	IN
cord-262445-54ng7m92	373	7	TFEB	TFEB	NNP
cord-262445-54ng7m92	373	8	transgenic	transgenic	JJ
cord-262445-54ng7m92	373	9	and	and	CC
cord-262445-54ng7m92	373	10	trained	train	VBN
cord-262445-54ng7m92	373	11	muscles	muscle	NNS
cord-262445-54ng7m92	373	12	,	,	,
cord-262445-54ng7m92	373	13	we	-PRON-	PRP
cord-262445-54ng7m92	373	14	found	find	VBD
cord-262445-54ng7m92	373	15	a	a	DT
cord-262445-54ng7m92	373	16	gene	gene	NN
cord-262445-54ng7m92	373	17	of	of	IN
cord-262445-54ng7m92	373	18	unknown	unknown	JJ
cord-262445-54ng7m92	373	19	function	function	NN
cord-262445-54ng7m92	373	20	belonging	belong	VBG
cord-262445-54ng7m92	373	21	to	to	IN
cord-262445-54ng7m92	373	22	the	the	DT
cord-262445-54ng7m92	373	23	Riken	Riken	NNP
cord-262445-54ng7m92	373	24	cDNA	cdna	NN
cord-262445-54ng7m92	373	25	collection	collection	NN
cord-262445-54ng7m92	373	26	that	that	WDT
cord-262445-54ng7m92	373	27	we	-PRON-	PRP
cord-262445-54ng7m92	373	28	called	call	VBD
cord-262445-54ng7m92	373	29	Exe	Exe	NNP
cord-262445-54ng7m92	373	30	-	-	HYPH
cord-262445-54ng7m92	373	31	Riken	Riken	NNP
cord-262445-54ng7m92	373	32	.	.	.
cord-262445-54ng7m92	374	1	Exe	Exe	NNP
cord-262445-54ng7m92	374	2	-	-	HYPH
cord-262445-54ng7m92	374	3	Riken	Riken	NNP
cord-262445-54ng7m92	374	4	encodes	encode	VBZ
cord-262445-54ng7m92	374	5	a	a	DT
cord-262445-54ng7m92	374	6	putative	putative	JJ
cord-262445-54ng7m92	374	7	125	125	CD
cord-262445-54ng7m92	374	8	residues	residue	NNS
cord-262445-54ng7m92	374	9	protein	protein	NN
cord-262445-54ng7m92	374	10	highly	highly	RB
cord-262445-54ng7m92	374	11	conserved	conserve	VBN
cord-262445-54ng7m92	374	12	among	among	IN
cord-262445-54ng7m92	374	13	mammals	mammal	NNS
cord-262445-54ng7m92	374	14	;	;	:
cord-262445-54ng7m92	374	15	interestingly	interestingly	RB
cord-262445-54ng7m92	374	16	,	,	,
cord-262445-54ng7m92	374	17	Exe	Exe	NNP
cord-262445-54ng7m92	374	18	-	-	HYPH
cord-262445-54ng7m92	374	19	Riken	Riken	NNP
cord-262445-54ng7m92	374	20	coding	coding	NN
cord-262445-54ng7m92	374	21	sequence	sequence	NN
cord-262445-54ng7m92	374	22	translates	translate	VBZ
cord-262445-54ng7m92	374	23	in	in	IN
cord-262445-54ng7m92	374	24	a	a	DT
cord-262445-54ng7m92	374	25	real	real	JJ
cord-262445-54ng7m92	374	26	protein	protein	NN
cord-262445-54ng7m92	374	27	when	when	WRB
cord-262445-54ng7m92	374	28	expressed	express	VBN
cord-262445-54ng7m92	374	29	in	in	IN
cord-262445-54ng7m92	374	30	vitro	vitro	FW
cord-262445-54ng7m92	374	31	and	and	CC
cord-262445-54ng7m92	374	32	in	in	IN
cord-262445-54ng7m92	374	33	vivo	vivo	NNP
cord-262445-54ng7m92	374	34	.	.	.
cord-262445-54ng7m92	375	1	Based	base	VBN
cord-262445-54ng7m92	375	2	on	on	IN
cord-262445-54ng7m92	375	3	gene	gene	NN
cord-262445-54ng7m92	375	4	expression	expression	NN
cord-262445-54ng7m92	375	5	databases	database	NNS
cord-262445-54ng7m92	375	6	,	,	,
cord-262445-54ng7m92	375	7	brown	brown	JJ
cord-262445-54ng7m92	375	8	adipose	adipose	NN
cord-262445-54ng7m92	375	9	and	and	CC
cord-262445-54ng7m92	375	10	gut	gut	NN
cord-262445-54ng7m92	375	11	are	be	VBP
cord-262445-54ng7m92	375	12	the	the	DT
cord-262445-54ng7m92	375	13	tissues	tissue	NNS
cord-262445-54ng7m92	375	14	with	with	IN
cord-262445-54ng7m92	375	15	higher	high	JJR
cord-262445-54ng7m92	375	16	basal	basal	NN
cord-262445-54ng7m92	375	17	Exe	Exe	NNP
cord-262445-54ng7m92	375	18	-	-	HYPH
cord-262445-54ng7m92	375	19	Riken	Riken	NNP
cord-262445-54ng7m92	375	20	expression	expression	NN
cord-262445-54ng7m92	375	21	in	in	IN
cord-262445-54ng7m92	375	22	mice	mouse	NNS
cord-262445-54ng7m92	375	23	.	.	.
cord-262445-54ng7m92	376	1	On	on	IN
cord-262445-54ng7m92	376	2	the	the	DT
cord-262445-54ng7m92	376	3	other	other	JJ
cord-262445-54ng7m92	376	4	hand	hand	NN
cord-262445-54ng7m92	376	5	,	,	,
cord-262445-54ng7m92	376	6	skeletal	skeletal	JJ
cord-262445-54ng7m92	376	7	muscle	muscle	NN
cord-262445-54ng7m92	376	8	transcript	transcript	NN
cord-262445-54ng7m92	376	9	levels	level	NNS
cord-262445-54ng7m92	376	10	are	be	VBP
cord-262445-54ng7m92	376	11	very	very	RB
cord-262445-54ng7m92	376	12	low	low	JJ
cord-262445-54ng7m92	376	13	,	,	,
cord-262445-54ng7m92	376	14	type	type	NN
cord-262445-54ng7m92	376	15	of	of	IN
cord-262445-54ng7m92	376	16	muscle	muscle	NN
cord-262445-54ng7m92	376	17	specific	specific	JJ
cord-262445-54ng7m92	376	18	and	and	CC
cord-262445-54ng7m92	376	19	finely	finely	RB
cord-262445-54ng7m92	376	20	tuned	tune	VBN
cord-262445-54ng7m92	376	21	with	with	IN
cord-262445-54ng7m92	376	22	different	different	JJ
cord-262445-54ng7m92	376	23	exercise	exercise	NN
cord-262445-54ng7m92	376	24	protocol	protocol	NN
cord-262445-54ng7m92	376	25	.	.	.
cord-262445-54ng7m92	377	1	In	in	IN
cord-262445-54ng7m92	377	2	addition	addition	NN
cord-262445-54ng7m92	377	3	,	,	,
cord-262445-54ng7m92	377	4	Exe	Exe	NNP
cord-262445-54ng7m92	377	5	-	-	HYPH
cord-262445-54ng7m92	377	6	Riken	Riken	NNP
cord-262445-54ng7m92	377	7	protein	protein	NN
cord-262445-54ng7m92	377	8	sequence	sequence	NN
cord-262445-54ng7m92	377	9	presents	present	VBZ
cord-262445-54ng7m92	377	10	a	a	DT
cord-262445-54ng7m92	377	11	Nuclear	Nuclear	NNP
cord-262445-54ng7m92	377	12	Export	Export	NNP
cord-262445-54ng7m92	377	13	Signal	Signal	NNP
cord-262445-54ng7m92	377	14	(	(	-LRB-
cord-262445-54ng7m92	377	15	NES	NES	NNP
cord-262445-54ng7m92	377	16	)	)	-RRB-
cord-262445-54ng7m92	377	17	and	and	CC
cord-262445-54ng7m92	377	18	Nuclear	Nuclear	NNP
cord-262445-54ng7m92	377	19	Localization	Localization	NNP
cord-262445-54ng7m92	377	20	Signal	Signal	NNP
cord-262445-54ng7m92	377	21	(	(	-LRB-
cord-262445-54ng7m92	377	22	NLS	NLS	NNP
cord-262445-54ng7m92	377	23	)	)	-RRB-
cord-262445-54ng7m92	377	24	,	,	,
cord-262445-54ng7m92	377	25	suggesting	suggest	VBG
cord-262445-54ng7m92	377	26	a	a	DT
cord-262445-54ng7m92	377	27	potential	potential	JJ
cord-262445-54ng7m92	377	28	shuttling	shuttle	VBG
cord-262445-54ng7m92	377	29	behavior	behavior	NN
cord-262445-54ng7m92	377	30	upon	upon	IN
cord-262445-54ng7m92	377	31	appropriate	appropriate	JJ
cord-262445-54ng7m92	377	32	stimuli	stimulus	NNS
cord-262445-54ng7m92	377	33	.	.	.
cord-262445-54ng7m92	378	1	Supporting	support	VBG
cord-262445-54ng7m92	378	2	this	this	DT
cord-262445-54ng7m92	378	3	idea	idea	NN
cord-262445-54ng7m92	378	4	,	,	,
cord-262445-54ng7m92	378	5	in	in	IN
cord-262445-54ng7m92	378	6	vivo	vivo	NN
cord-262445-54ng7m92	378	7	experiments	experiment	NNS
cord-262445-54ng7m92	378	8	demonstrate	demonstrate	VBP
cord-262445-54ng7m92	378	9	Exe	Exe	NNP
cord-262445-54ng7m92	378	10	-	-	HYPH
cord-262445-54ng7m92	378	11	Riken	Riken	NNP
cord-262445-54ng7m92	378	12	nuclear	nuclear	JJ
cord-262445-54ng7m92	378	13	translocation	translocation	NN
cord-262445-54ng7m92	378	14	upon	upon	IN
cord-262445-54ng7m92	378	15	exercise	exercise	NN
cord-262445-54ng7m92	378	16	.	.	.
cord-262445-54ng7m92	379	1	Finally	finally	RB
cord-262445-54ng7m92	379	2	,	,	,
cord-262445-54ng7m92	379	3	overexpression	overexpression	NN
cord-262445-54ng7m92	379	4	studies	study	NNS
cord-262445-54ng7m92	379	5	in	in	IN
cord-262445-54ng7m92	379	6	adult	adult	NN
cord-262445-54ng7m92	379	7	Tibialis	Tibialis	NNP
cord-262445-54ng7m92	379	8	Anterior	Anterior	NNP
cord-262445-54ng7m92	379	9	muscle	muscle	NN
cord-262445-54ng7m92	379	10	showed	show	VBD
cord-262445-54ng7m92	379	11	an	an	DT
cord-262445-54ng7m92	379	12	increased	increase	VBN
cord-262445-54ng7m92	379	13	SDH	SDH	NNP
cord-262445-54ng7m92	379	14	activity	activity	NN
cord-262445-54ng7m92	379	15	and	and	CC
cord-262445-54ng7m92	379	16	a	a	DT
cord-262445-54ng7m92	379	17	decreased	decrease	VBN
cord-262445-54ng7m92	379	18	PAS	pas	NN
cord-262445-54ng7m92	379	19	staining	staining	NN
cord-262445-54ng7m92	379	20	,	,	,
cord-262445-54ng7m92	379	21	suggesting	suggest	VBG
cord-262445-54ng7m92	379	22	its	-PRON-	PRP$
cord-262445-54ng7m92	379	23	impact	impact	NN
cord-262445-54ng7m92	379	24	in	in	IN
cord-262445-54ng7m92	379	25	muscle	muscle	NN
cord-262445-54ng7m92	379	26	metabolism	metabolism	NN
cord-262445-54ng7m92	379	27	.	.	.
cord-262445-54ng7m92	380	1	Overall	overall	RB
cord-262445-54ng7m92	380	2	these	these	DT
cord-262445-54ng7m92	380	3	findings	finding	NNS
cord-262445-54ng7m92	380	4	highlight	highlight	VBP
cord-262445-54ng7m92	380	5	a	a	DT
cord-262445-54ng7m92	380	6	possible	possible	JJ
cord-262445-54ng7m92	380	7	role	role	NN
cord-262445-54ng7m92	380	8	of	of	IN
cord-262445-54ng7m92	380	9	this	this	DT
cord-262445-54ng7m92	380	10	new	new	JJ
cord-262445-54ng7m92	380	11	gene	gene	NN
cord-262445-54ng7m92	380	12	in	in	IN
cord-262445-54ng7m92	380	13	controlling	control	VBG
cord-262445-54ng7m92	380	14	metabolic	metabolic	JJ
cord-262445-54ng7m92	380	15	adaptations	adaptation	NNS
cord-262445-54ng7m92	380	16	during	during	IN
cord-262445-54ng7m92	380	17	physical	physical	JJ
cord-262445-54ng7m92	380	18	activity	activity	NN
cord-262445-54ng7m92	380	19	.	.	.
cord-262445-54ng7m92	381	1	Cholecalciferol	Cholecalciferol	NNP
cord-262445-54ng7m92	381	2	,	,	,
cord-262445-54ng7m92	381	3	or	or	CC
cord-262445-54ng7m92	381	4	vitamin	vitamin	NN
cord-262445-54ng7m92	381	5	D3	D3	NNP
cord-262445-54ng7m92	381	6	(	(	-LRB-
cord-262445-54ng7m92	381	7	VD	VD	NNP
cord-262445-54ng7m92	381	8	hereafter	hereafter	RB
cord-262445-54ng7m92	381	9	for	for	IN
cord-262445-54ng7m92	381	10	brevity	brevity	NN
cord-262445-54ng7m92	381	11	)	)	-RRB-
cord-262445-54ng7m92	381	12	,	,	,
cord-262445-54ng7m92	381	13	besides	besides	IN
cord-262445-54ng7m92	381	14	its	-PRON-	PRP$
cord-262445-54ng7m92	381	15	well	well	RB
cord-262445-54ng7m92	381	16	-	-	HYPH
cord-262445-54ng7m92	381	17	known	know	VBN
cord-262445-54ng7m92	381	18	role	role	NN
cord-262445-54ng7m92	381	19	in	in	IN
cord-262445-54ng7m92	381	20	regulation	regulation	NN
cord-262445-54ng7m92	381	21	of	of	IN
cord-262445-54ng7m92	381	22	calcium	calcium	NN
cord-262445-54ng7m92	381	23	and	and	CC
cord-262445-54ng7m92	381	24	phosphate	phosphate	NN
cord-262445-54ng7m92	381	25	homeostasis	homeostasis	NN
cord-262445-54ng7m92	381	26	,	,	,
cord-262445-54ng7m92	381	27	impacts	impact	NNS
cord-262445-54ng7m92	381	28	on	on	IN
cord-262445-54ng7m92	381	29	skeletal	skeletal	JJ
cord-262445-54ng7m92	381	30	muscle	muscle	NN
cord-262445-54ng7m92	381	31	homeostasis	homeostasis	NN
cord-262445-54ng7m92	381	32	as	as	RB
cord-262445-54ng7m92	381	33	well	well	RB
cord-262445-54ng7m92	381	34	,	,	,
cord-262445-54ng7m92	381	35	and	and	CC
cord-262445-54ng7m92	381	36	VD	VD	NNP
cord-262445-54ng7m92	381	37	deficiency	deficiency	NN
cord-262445-54ng7m92	381	38	has	have	VBZ
cord-262445-54ng7m92	381	39	been	be	VBN
cord-262445-54ng7m92	381	40	correlated	correlate	VBN
cord-262445-54ng7m92	381	41	with	with	IN
cord-262445-54ng7m92	381	42	decrease	decrease	NN
cord-262445-54ng7m92	381	43	in	in	IN
cord-262445-54ng7m92	381	44	muscle	muscle	NN
cord-262445-54ng7m92	381	45	mass	mass	NN
cord-262445-54ng7m92	381	46	,	,	,
cord-262445-54ng7m92	381	47	function	function	NN
cord-262445-54ng7m92	381	48	,	,	,
cord-262445-54ng7m92	381	49	and	and	CC
cord-262445-54ng7m92	381	50	performance	performance	NN
cord-262445-54ng7m92	381	51	in	in	IN
cord-262445-54ng7m92	381	52	elderly	elderly	JJ
cord-262445-54ng7m92	381	53	subjects	subject	NNS
cord-262445-54ng7m92	381	54	,	,	,
cord-262445-54ng7m92	381	55	as	as	RB
cord-262445-54ng7m92	381	56	well	well	RB
cord-262445-54ng7m92	381	57	as	as	IN
cord-262445-54ng7m92	381	58	in	in	IN
cord-262445-54ng7m92	381	59	cachectic	cachectic	JJ
cord-262445-54ng7m92	381	60	cancer	cancer	NN
cord-262445-54ng7m92	381	61	patients	patient	NNS
cord-262445-54ng7m92	381	62	.	.	.
cord-262445-54ng7m92	382	1	While	while	IN
cord-262445-54ng7m92	382	2	VD	VD	NNP
cord-262445-54ng7m92	382	3	supplementation	supplementation	NN
cord-262445-54ng7m92	382	4	was	be	VBD
cord-262445-54ng7m92	382	5	able	able	JJ
cord-262445-54ng7m92	382	6	to	to	TO
cord-262445-54ng7m92	382	7	restore	restore	VB
cord-262445-54ng7m92	382	8	muscle	muscle	NN
cord-262445-54ng7m92	382	9	strength	strength	NN
cord-262445-54ng7m92	382	10	and	and	CC
cord-262445-54ng7m92	382	11	prevent	prevent	VB
cord-262445-54ng7m92	382	12	muscle	muscle	NN
cord-262445-54ng7m92	382	13	mass	mass	NN
cord-262445-54ng7m92	382	14	loss	loss	NN
cord-262445-54ng7m92	382	15	in	in	IN
cord-262445-54ng7m92	382	16	frail	frail	JJ
cord-262445-54ng7m92	382	17	elderly	elderly	JJ
cord-262445-54ng7m92	382	18	subjects	subject	NNS
cord-262445-54ng7m92	382	19	,	,	,
cord-262445-54ng7m92	382	20	it	-PRON-	PRP
cord-262445-54ng7m92	382	21	was	be	VBD
cord-262445-54ng7m92	382	22	ineffective	ineffective	JJ
cord-262445-54ng7m92	382	23	in	in	IN
cord-262445-54ng7m92	382	24	the	the	DT
cord-262445-54ng7m92	382	25	case	case	NN
cord-262445-54ng7m92	382	26	of	of	IN
cord-262445-54ng7m92	382	27	cancer	cancer	NN
cord-262445-54ng7m92	382	28	cachexia	cachexia	NN
cord-262445-54ng7m92	382	29	-	-	HYPH
cord-262445-54ng7m92	382	30	associated	associate	VBN
cord-262445-54ng7m92	382	31	muscle	muscle	NN
cord-262445-54ng7m92	382	32	wasting	wasting	NN
cord-262445-54ng7m92	382	33	.	.	.
cord-262445-54ng7m92	383	1	Investigating	investigate	VBG
cord-262445-54ng7m92	383	2	the	the	DT
cord-262445-54ng7m92	383	3	direct	direct	JJ
cord-262445-54ng7m92	383	4	effects	effect	NNS
cord-262445-54ng7m92	383	5	of	of	IN
cord-262445-54ng7m92	383	6	the	the	DT
cord-262445-54ng7m92	383	7	main	main	JJ
cord-262445-54ng7m92	383	8	cholecalciferol	cholecalciferol	NN
cord-262445-54ng7m92	383	9	-	-	HYPH
cord-262445-54ng7m92	383	10	derived	derive	VBN
cord-262445-54ng7m92	383	11	metabolites	metabolite	NNS
cord-262445-54ng7m92	383	12	-namely	-namely	RB
cord-262445-54ng7m92	383	13	1,25-(OH)2-VD	1,25-(oh)2-vd	CD
cord-262445-54ng7m92	383	14	and	and	CC
cord-262445-54ng7m92	383	15	its	-PRON-	PRP$
cord-262445-54ng7m92	383	16	precursor	precursor	NN
cord-262445-54ng7m92	383	17	25-OH	25-oh	CD
cord-262445-54ng7m92	383	18	-	-	HYPH
cord-262445-54ng7m92	383	19	VD	vd	NN
cord-262445-54ng7m92	383	20	-	-	HYPH
cord-262445-54ng7m92	383	21	on	on	RP
cord-262445-54ng7m92	383	22	skeletal	skeletal	JJ
cord-262445-54ng7m92	383	23	muscle	muscle	NN
cord-262445-54ng7m92	383	24	cells	cell	NNS
cord-262445-54ng7m92	383	25	,	,	,
cord-262445-54ng7m92	383	26	we	-PRON-	PRP
cord-262445-54ng7m92	383	27	found	find	VBD
cord-262445-54ng7m92	383	28	divergent	divergent	JJ
cord-262445-54ng7m92	383	29	effects	effect	NNS
cord-262445-54ng7m92	383	30	of	of	IN
cord-262445-54ng7m92	383	31	these	these	DT
cord-262445-54ng7m92	383	32	molecules	molecule	NNS
cord-262445-54ng7m92	383	33	in	in	IN
cord-262445-54ng7m92	383	34	promoting	promote	VBG
cord-262445-54ng7m92	383	35	/	/	SYM
cord-262445-54ng7m92	383	36	preserving	preserve	VBG
cord-262445-54ng7m92	383	37	from	from	IN
cord-262445-54ng7m92	383	38	atrophy	atrophy	NN
cord-262445-54ng7m92	383	39	induced	induce	VBN
cord-262445-54ng7m92	383	40	by	by	IN
cord-262445-54ng7m92	383	41	pro	pro	JJ
cord-262445-54ng7m92	383	42	-	-	JJ
cord-262445-54ng7m92	383	43	cachectic	cachectic	JJ
cord-262445-54ng7m92	383	44	cytokines	cytokine	NNS
cord-262445-54ng7m92	383	45	.	.	.
cord-262445-54ng7m92	384	1	Given	give	VBN
cord-262445-54ng7m92	384	2	the	the	DT
cord-262445-54ng7m92	384	3	anti	anti	JJ
cord-262445-54ng7m92	384	4	-	-	JJ
cord-262445-54ng7m92	384	5	atrophic	atrophic	JJ
cord-262445-54ng7m92	384	6	action	action	NN
cord-262445-54ng7m92	384	7	of	of	IN
cord-262445-54ng7m92	384	8	25-OH	25-oh	CD
cord-262445-54ng7m92	384	9	-	-	HYPH
cord-262445-54ng7m92	384	10	VD	VD	NNP
cord-262445-54ng7m92	384	11	,	,	,
cord-262445-54ng7m92	384	12	we	-PRON-	PRP
cord-262445-54ng7m92	384	13	wondered	wonder	VBD
cord-262445-54ng7m92	384	14	if	if	IN
cord-262445-54ng7m92	384	15	also	also	RB
cord-262445-54ng7m92	384	16	the	the	DT
cord-262445-54ng7m92	384	17	pro	pro	JJ
cord-262445-54ng7m92	384	18	-	-	JJ
cord-262445-54ng7m92	384	19	hormone	hormone	JJ
cord-262445-54ng7m92	384	20	VD	vd	NN
cord-262445-54ng7m92	384	21	could	could	MD
cord-262445-54ng7m92	384	22	have	have	VB
cord-262445-54ng7m92	384	23	a	a	DT
cord-262445-54ng7m92	384	24	direct	direct	JJ
cord-262445-54ng7m92	384	25	activity	activity	NN
cord-262445-54ng7m92	384	26	on	on	IN
cord-262445-54ng7m92	384	27	skeletal	skeletal	JJ
cord-262445-54ng7m92	384	28	muscle	muscle	NN
cord-262445-54ng7m92	384	29	cells	cell	NNS
cord-262445-54ng7m92	384	30	.	.	.
cord-262445-54ng7m92	385	1	For	for	IN
cord-262445-54ng7m92	385	2	this	this	DT
cord-262445-54ng7m92	385	3	purpose	purpose	NN
cord-262445-54ng7m92	385	4	,	,	,
cord-262445-54ng7m92	385	5	we	-PRON-	PRP
cord-262445-54ng7m92	385	6	used	use	VBD
cord-262445-54ng7m92	385	7	an	an	DT
cord-262445-54ng7m92	385	8	in	in	FW
cord-262445-54ng7m92	385	9	vitro	vitro	FW
cord-262445-54ng7m92	385	10	model	model	NN
cord-262445-54ng7m92	385	11	of	of	IN
cord-262445-54ng7m92	385	12	cytokine	cytokine	NN
cord-262445-54ng7m92	385	13	-	-	HYPH
cord-262445-54ng7m92	385	14	induced	induce	VBN
cord-262445-54ng7m92	385	15	atrophy	atrophy	NN
cord-262445-54ng7m92	385	16	and	and	CC
cord-262445-54ng7m92	385	17	found	find	VBD
cord-262445-54ng7m92	385	18	that	that	IN
cord-262445-54ng7m92	385	19	also	also	RB
cord-262445-54ng7m92	385	20	VD	VD	NNP
cord-262445-54ng7m92	385	21	has	have	VBZ
cord-262445-54ng7m92	385	22	a	a	DT
cord-262445-54ng7m92	385	23	protective	protective	JJ
cord-262445-54ng7m92	385	24	action	action	NN
cord-262445-54ng7m92	385	25	.	.	.
cord-262445-54ng7m92	386	1	Intriguingly	intriguingly	RB
cord-262445-54ng7m92	386	2	,	,	,
cord-262445-54ng7m92	386	3	the	the	DT
cord-262445-54ng7m92	386	4	activity	activity	NN
cord-262445-54ng7m92	386	5	of	of	IN
cord-262445-54ng7m92	386	6	VD	VD	NNP
cord-262445-54ng7m92	386	7	is	be	VBZ
cord-262445-54ng7m92	386	8	notmediated	notmediate	VBN
cord-262445-54ng7m92	386	9	by	by	IN
cord-262445-54ng7m92	386	10	an	an	DT
cord-262445-54ng7m92	386	11	intracellular	intracellular	JJ
cord-262445-54ng7m92	386	12	conversion	conversion	NN
cord-262445-54ng7m92	386	13	in	in	IN
cord-262445-54ng7m92	386	14	the	the	DT
cord-262445-54ng7m92	386	15	protective	protective	JJ
cord-262445-54ng7m92	386	16	form	form	NN
cord-262445-54ng7m92	386	17	25-OH	25-oh	CD
cord-262445-54ng7m92	386	18	-	-	HYPH
cord-262445-54ng7m92	386	19	VD	VD	NNP
cord-262445-54ng7m92	386	20	.	.	.
cord-262445-54ng7m92	387	1	Our	-PRON-	PRP$
cord-262445-54ng7m92	387	2	recent	recent	JJ
cord-262445-54ng7m92	387	3	study	study	NN
cord-262445-54ng7m92	387	4	revealed	reveal	VBD
cord-262445-54ng7m92	387	5	the	the	DT
cord-262445-54ng7m92	387	6	existence	existence	NN
cord-262445-54ng7m92	387	7	of	of	IN
cord-262445-54ng7m92	387	8	a	a	DT
cord-262445-54ng7m92	387	9	novel	novel	JJ
cord-262445-54ng7m92	387	10	embryonic	embryonic	JJ
cord-262445-54ng7m92	387	11	isoform	isoform	NN
cord-262445-54ng7m92	387	12	of	of	IN
cord-262445-54ng7m92	387	13	CaVβ1	CaVβ1	NNS
cord-262445-54ng7m92	387	14	(	(	-LRB-
cord-262445-54ng7m92	387	15	CaVβ1E	CaVβ1E	NNP
cord-262445-54ng7m92	387	16	)	)	-RRB-
cord-262445-54ng7m92	387	17	,	,	,
cord-262445-54ng7m92	387	18	the	the	DT
cord-262445-54ng7m92	387	19	beta	beta	NN
cord-262445-54ng7m92	387	20	subunit	subunit	NN
cord-262445-54ng7m92	387	21	of	of	IN
cord-262445-54ng7m92	387	22	CaV1.1	CaV1.1	NNS
cord-262445-54ng7m92	387	23	,	,	,
cord-262445-54ng7m92	387	24	which	which	WDT
cord-262445-54ng7m92	387	25	expression	expression	NN
cord-262445-54ng7m92	387	26	increases	increase	VBZ
cord-262445-54ng7m92	387	27	in	in	IN
cord-262445-54ng7m92	387	28	adult	adult	NN
cord-262445-54ng7m92	387	29	muscle	muscle	NN
cord-262445-54ng7m92	387	30	after	after	IN
cord-262445-54ng7m92	387	31	denervation	denervation	NN
cord-262445-54ng7m92	387	32	.	.	.
cord-262445-54ng7m92	388	1	The	the	DT
cord-262445-54ng7m92	388	2	increase	increase	NN
cord-262445-54ng7m92	388	3	of	of	IN
cord-262445-54ng7m92	388	4	CaVβ1E	CaVβ1E	NNP
cord-262445-54ng7m92	388	5	expression	expression	NN
cord-262445-54ng7m92	388	6	boosts	boost	VBZ
cord-262445-54ng7m92	388	7	downstream	downstream	JJ
cord-262445-54ng7m92	388	8	Gdf5	Gdf5	NNP
cord-262445-54ng7m92	388	9	signaling	signal	VBG
cord-262445-54ng7m92	388	10	to	to	TO
cord-262445-54ng7m92	388	11	counteract	counteract	VB
cord-262445-54ng7m92	388	12	muscle	muscle	NN
cord-262445-54ng7m92	388	13	atrophy	atrophy	NN
cord-262445-54ng7m92	388	14	due	due	IN
cord-262445-54ng7m92	388	15	to	to	IN
cord-262445-54ng7m92	388	16	nerve	nerve	NN
cord-262445-54ng7m92	388	17	damage	damage	NN
cord-262445-54ng7m92	388	18	.	.	.
cord-262445-54ng7m92	389	1	We	-PRON-	PRP
cord-262445-54ng7m92	389	2	further	further	RB
cord-262445-54ng7m92	389	3	reported	report	VBD
cord-262445-54ng7m92	389	4	that	that	IN
cord-262445-54ng7m92	389	5	aged	aged	JJ
cord-262445-54ng7m92	389	6	muscle	muscle	NN
cord-262445-54ng7m92	389	7	expresses	express	VBZ
cord-262445-54ng7m92	389	8	significantly	significantly	RB
cord-262445-54ng7m92	389	9	reduced	reduce	VBN
cord-262445-54ng7m92	389	10	levels	level	NNS
cord-262445-54ng7m92	389	11	of	of	IN
cord-262445-54ng7m92	389	12	CaVβ1E	CaVβ1E	NNP
cord-262445-54ng7m92	389	13	and	and	CC
cord-262445-54ng7m92	389	14	that	that	IN
cord-262445-54ng7m92	389	15	its	-PRON-	PRP$
cord-262445-54ng7m92	389	16	overexpression	overexpression	NN
cord-262445-54ng7m92	389	17	improves	improve	VBZ
cord-262445-54ng7m92	389	18	mass	mass	NN
cord-262445-54ng7m92	389	19	wasting	wasting	NN
cord-262445-54ng7m92	389	20	in	in	IN
cord-262445-54ng7m92	389	21	aging	age	VBG
cord-262445-54ng7m92	389	22	muscle	muscle	NN
cord-262445-54ng7m92	389	23	by	by	IN
cord-262445-54ng7m92	389	24	increasing	increase	VBG
cord-262445-54ng7m92	389	25	Gdf5	Gdf5	NNP
cord-262445-54ng7m92	389	26	expression	expression	NN
cord-262445-54ng7m92	389	27	.	.	.
cord-262445-54ng7m92	390	1	Crucially	crucially	RB
cord-262445-54ng7m92	390	2	,	,	,
cord-262445-54ng7m92	390	3	we	-PRON-	PRP
cord-262445-54ng7m92	390	4	also	also	RB
cord-262445-54ng7m92	390	5	identified	identify	VBD
cord-262445-54ng7m92	390	6	the	the	DT
cord-262445-54ng7m92	390	7	human	human	JJ
cord-262445-54ng7m92	390	8	CaVβ1E	CaVβ1E	NNP
cord-262445-54ng7m92	390	9	analogous	analogous	JJ
cord-262445-54ng7m92	390	10	and	and	CC
cord-262445-54ng7m92	390	11	showed	show	VBD
cord-262445-54ng7m92	390	12	a	a	DT
cord-262445-54ng7m92	390	13	correlation	correlation	NN
cord-262445-54ng7m92	390	14	between	between	IN
cord-262445-54ng7m92	390	15	the	the	DT
cord-262445-54ng7m92	390	16	decrease	decrease	NN
cord-262445-54ng7m92	390	17	of	of	IN
cord-262445-54ng7m92	390	18	CaVβ1E	CaVβ1E	NNP
cord-262445-54ng7m92	390	19	expression	expression	NN
cord-262445-54ng7m92	390	20	and	and	CC
cord-262445-54ng7m92	390	21	the	the	DT
cord-262445-54ng7m92	390	22	age	age	NN
cord-262445-54ng7m92	390	23	-	-	HYPH
cord-262445-54ng7m92	390	24	related	relate	VBN
cord-262445-54ng7m92	390	25	muscle	muscle	NN
cord-262445-54ng7m92	390	26	mass	mass	NN
cord-262445-54ng7m92	390	27	decline	decline	NN
cord-262445-54ng7m92	390	28	in	in	IN
cord-262445-54ng7m92	390	29	people	people	NNS
cord-262445-54ng7m92	390	30	.	.	.
cord-262445-54ng7m92	391	1	Altogether	altogether	RB
cord-262445-54ng7m92	391	2	,	,	,
cord-262445-54ng7m92	391	3	our	-PRON-	PRP$
cord-262445-54ng7m92	391	4	data	datum	NNS
cord-262445-54ng7m92	391	5	open	open	VBP
cord-262445-54ng7m92	391	6	a	a	DT
cord-262445-54ng7m92	391	7	new	new	JJ
cord-262445-54ng7m92	391	8	field	field	NN
cord-262445-54ng7m92	391	9	in	in	IN
cord-262445-54ng7m92	391	10	the	the	DT
cord-262445-54ng7m92	391	11	development	development	NN
cord-262445-54ng7m92	391	12	of	of	IN
cord-262445-54ng7m92	391	13	strategies	strategy	NNS
cord-262445-54ng7m92	391	14	against	against	IN
cord-262445-54ng7m92	391	15	muscle	muscle	NN
cord-262445-54ng7m92	391	16	mass	mass	NN
cord-262445-54ng7m92	391	17	loss	loss	NN
cord-262445-54ng7m92	391	18	during	during	IN
cord-262445-54ng7m92	391	19	senescence	senescence	NN
cord-262445-54ng7m92	391	20	.	.	.
cord-262445-54ng7m92	392	1	Here	here	RB
cord-262445-54ng7m92	392	2	,	,	,
cord-262445-54ng7m92	392	3	we	-PRON-	PRP
cord-262445-54ng7m92	392	4	have	have	VBP
cord-262445-54ng7m92	392	5	preliminary	preliminary	JJ
cord-262445-54ng7m92	392	6	data	datum	NNS
cord-262445-54ng7m92	392	7	indicating	indicate	VBG
cord-262445-54ng7m92	392	8	that	that	IN
cord-262445-54ng7m92	392	9	the	the	DT
cord-262445-54ng7m92	392	10	systemic	systemic	JJ
cord-262445-54ng7m92	392	11	administration	administration	NN
cord-262445-54ng7m92	392	12	of	of	IN
cord-262445-54ng7m92	392	13	the	the	DT
cord-262445-54ng7m92	392	14	recombinant	recombinant	JJ
cord-262445-54ng7m92	392	15	Gdf5	Gdf5	NNP
cord-262445-54ng7m92	392	16	protein	protein	NN
cord-262445-54ng7m92	392	17	(	(	-LRB-
cord-262445-54ng7m92	392	18	rGdf5	rGdf5	NNP
cord-262445-54ng7m92	392	19	)	)	-RRB-
cord-262445-54ng7m92	392	20	represents	represent	VBZ
cord-262445-54ng7m92	392	21	a	a	DT
cord-262445-54ng7m92	392	22	promising	promising	JJ
cord-262445-54ng7m92	392	23	therapeutic	therapeutic	JJ
cord-262445-54ng7m92	392	24	approach	approach	NN
cord-262445-54ng7m92	392	25	to	to	TO
cord-262445-54ng7m92	392	26	improve	improve	VB
cord-262445-54ng7m92	392	27	age	age	NN
cord-262445-54ng7m92	392	28	-	-	HYPH
cord-262445-54ng7m92	392	29	related	relate	VBN
cord-262445-54ng7m92	392	30	muscle	muscle	NN
cord-262445-54ng7m92	392	31	wasting	wasting	NN
cord-262445-54ng7m92	392	32	.	.	.
cord-262445-54ng7m92	393	1	In	in	IN
cord-262445-54ng7m92	393	2	a	a	DT
cord-262445-54ng7m92	393	3	pilot	pilot	NN
cord-262445-54ng7m92	393	4	study	study	NN
cord-262445-54ng7m92	393	5	,	,	,
cord-262445-54ng7m92	393	6	old	old	JJ
cord-262445-54ng7m92	393	7	mice	mouse	NNS
cord-262445-54ng7m92	393	8	(	(	-LRB-
cord-262445-54ng7m92	393	9	90	90	CD
cord-262445-54ng7m92	393	10	weeks	week	NNS
cord-262445-54ng7m92	393	11	old	old	JJ
cord-262445-54ng7m92	393	12	)	)	-RRB-
cord-262445-54ng7m92	393	13	were	be	VBD
cord-262445-54ng7m92	393	14	treated	treat	VBN
cord-262445-54ng7m92	393	15	with	with	IN
cord-262445-54ng7m92	393	16	rGdf5	rGdf5	NNP
cord-262445-54ng7m92	393	17	,	,	,
cord-262445-54ng7m92	393	18	by	by	IN
cord-262445-54ng7m92	393	19	systemic	systemic	JJ
cord-262445-54ng7m92	393	20	delivery	delivery	NN
cord-262445-54ng7m92	393	21	,	,	,
cord-262445-54ng7m92	393	22	for	for	IN
cord-262445-54ng7m92	393	23	ten	ten	CD
cord-262445-54ng7m92	393	24	weeks	week	NNS
cord-262445-54ng7m92	393	25	.	.	.
cord-262445-54ng7m92	394	1	Strikingly	strikingly	RB
cord-262445-54ng7m92	394	2	,	,	,
cord-262445-54ng7m92	394	3	rGdf5	rGdf5	NNP
cord-262445-54ng7m92	394	4	implementation	implementation	NN
cord-262445-54ng7m92	394	5	induced	induce	VBD
cord-262445-54ng7m92	394	6	a	a	DT
cord-262445-54ng7m92	394	7	significant	significant	JJ
cord-262445-54ng7m92	394	8	increase	increase	NN
cord-262445-54ng7m92	394	9	of	of	IN
cord-262445-54ng7m92	394	10	lean	lean	JJ
cord-262445-54ng7m92	394	11	mass	mass	NN
cord-262445-54ng7m92	394	12	and	and	CC
cord-262445-54ng7m92	394	13	a	a	DT
cord-262445-54ng7m92	394	14	decrease	decrease	NN
cord-262445-54ng7m92	394	15	of	of	IN
cord-262445-54ng7m92	394	16	the	the	DT
cord-262445-54ng7m92	394	17	fat	fat	JJ
cord-262445-54ng7m92	394	18	mass	mass	NN
cord-262445-54ng7m92	394	19	.	.	.
cord-262445-54ng7m92	395	1	Indeed	indeed	RB
cord-262445-54ng7m92	395	2	,	,	,
cord-262445-54ng7m92	395	3	muscle	muscle	NN
cord-262445-54ng7m92	395	4	/	/	SYM
cord-262445-54ng7m92	395	5	body	body	NN
cord-262445-54ng7m92	395	6	-	-	HYPH
cord-262445-54ng7m92	395	7	weight	weight	NN
cord-262445-54ng7m92	395	8	ratios	ratio	NNS
cord-262445-54ng7m92	395	9	of	of	IN
cord-262445-54ng7m92	395	10	TAs	ta	NNS
cord-262445-54ng7m92	395	11	and	and	CC
cord-262445-54ng7m92	395	12	Quadriceps	Quadriceps	NNPS
cord-262445-54ng7m92	395	13	(	(	-LRB-
cord-262445-54ng7m92	395	14	Quad	Quad	NNP
cord-262445-54ng7m92	395	15	)	)	-RRB-
cord-262445-54ng7m92	395	16	were	be	VBD
cord-262445-54ng7m92	395	17	significantly	significantly	RB
cord-262445-54ng7m92	395	18	increased	increase	VBN
cord-262445-54ng7m92	395	19	in	in	IN
cord-262445-54ng7m92	395	20	the	the	DT
cord-262445-54ng7m92	395	21	rGdf5	rGdf5	NNP
cord-262445-54ng7m92	395	22	-	-	HYPH
cord-262445-54ng7m92	395	23	100	100	CD
cord-262445-54ng7m92	395	24	weeks	week	NNS
cord-262445-54ng7m92	395	25	old	old	JJ
cord-262445-54ng7m92	395	26	mice	mouse	NNS
cord-262445-54ng7m92	395	27	compared	compare	VBN
cord-262445-54ng7m92	395	28	to	to	IN
cord-262445-54ng7m92	395	29	vehicle	vehicle	NN
cord-262445-54ng7m92	395	30	-	-	HYPH
cord-262445-54ng7m92	395	31	treated	treat	VBN
cord-262445-54ng7m92	395	32	old	old	JJ
cord-262445-54ng7m92	395	33	mice	mouse	NNS
cord-262445-54ng7m92	395	34	.	.	.
cord-262445-54ng7m92	396	1	In	in	IN
cord-262445-54ng7m92	396	2	order	order	NN
cord-262445-54ng7m92	396	3	to	to	TO
cord-262445-54ng7m92	396	4	evaluate	evaluate	VB
cord-262445-54ng7m92	396	5	the	the	DT
cord-262445-54ng7m92	396	6	possible	possible	JJ
cord-262445-54ng7m92	396	7	mechanisms	mechanism	NNS
cord-262445-54ng7m92	396	8	behind	behind	IN
cord-262445-54ng7m92	396	9	rGdf5	rGdf5	NNP
cord-262445-54ng7m92	396	10	effects	effect	NNS
cord-262445-54ng7m92	396	11	in	in	IN
cord-262445-54ng7m92	396	12	muscle	muscle	NN
cord-262445-54ng7m92	396	13	,	,	,
cord-262445-54ng7m92	396	14	we	-PRON-	PRP
cord-262445-54ng7m92	396	15	analyzed	analyze	VBD
cord-262445-54ng7m92	396	16	:	:	:
cord-262445-54ng7m92	396	17	a	a	LS
cord-262445-54ng7m92	396	18	)	)	-RRB-
cord-262445-54ng7m92	396	19	Myostatin	Myostatin	NNP
cord-262445-54ng7m92	396	20	(	(	-LRB-
cord-262445-54ng7m92	396	21	Gdf8	Gdf8	NNP
cord-262445-54ng7m92	396	22	)	)	-RRB-
cord-262445-54ng7m92	396	23	pathway	pathway	NN
cord-262445-54ng7m92	396	24	,	,	,
cord-262445-54ng7m92	396	25	involved	involve	VBN
cord-262445-54ng7m92	396	26	in	in	IN
cord-262445-54ng7m92	396	27	protein	protein	NN
cord-262445-54ng7m92	396	28	degradation	degradation	NN
cord-262445-54ng7m92	396	29	;	;	:
cord-262445-54ng7m92	396	30	b	b	LS
cord-262445-54ng7m92	396	31	)	)	-RRB-
cord-262445-54ng7m92	396	32	neuromuscular	neuromuscular	NN
cord-262445-54ng7m92	396	33	junction	junction	NN
cord-262445-54ng7m92	396	34	(	(	-LRB-
cord-262445-54ng7m92	396	35	NMJ	NMJ	NNP
cord-262445-54ng7m92	396	36	)	)	-RRB-
cord-262445-54ng7m92	396	37	status	status	NN
cord-262445-54ng7m92	396	38	by	by	IN
cord-262445-54ng7m92	396	39	measuring	measure	VBG
cord-262445-54ng7m92	396	40	the	the	DT
cord-262445-54ng7m92	396	41	expression	expression	NN
cord-262445-54ng7m92	396	42	of	of	IN
cord-262445-54ng7m92	396	43	acetylcholin	acetylcholin	NNP
cord-262445-54ng7m92	396	44	receptor	receptor	NN
cord-262445-54ng7m92	396	45	subunit	subunit	NN
cord-262445-54ng7m92	396	46	epsilon	epsilon	NN
cord-262445-54ng7m92	396	47	(	(	-LRB-
cord-262445-54ng7m92	396	48	Chrnε	Chrnε	NNP
cord-262445-54ng7m92	396	49	)	)	-RRB-
cord-262445-54ng7m92	396	50	.	.	.
cord-262445-54ng7m92	397	1	We	-PRON-	PRP
cord-262445-54ng7m92	397	2	found	find	VBD
cord-262445-54ng7m92	397	3	a	a	DT
cord-262445-54ng7m92	397	4	significant	significant	JJ
cord-262445-54ng7m92	397	5	decrease	decrease	NN
cord-262445-54ng7m92	397	6	in	in	IN
cord-262445-54ng7m92	397	7	myostatin	myostatin	NN
cord-262445-54ng7m92	397	8	pathway	pathway	NN
cord-262445-54ng7m92	397	9	activation	activation	NN
cord-262445-54ng7m92	397	10	in	in	IN
cord-262445-54ng7m92	397	11	muscle	muscle	NN
cord-262445-54ng7m92	397	12	treated	treat	VBN
cord-262445-54ng7m92	397	13	with	with	IN
cord-262445-54ng7m92	397	14	rGdf5	rGdf5	NNP
cord-262445-54ng7m92	397	15	,	,	,
cord-262445-54ng7m92	397	16	suggesting	suggest	VBG
cord-262445-54ng7m92	397	17	his	-PRON-	PRP$
cord-262445-54ng7m92	397	18	protective	protective	JJ
cord-262445-54ng7m92	397	19	role	role	NN
cord-262445-54ng7m92	397	20	against	against	IN
cord-262445-54ng7m92	397	21	myostatin	myostatin	NN
cord-262445-54ng7m92	397	22	-	-	HYPH
cord-262445-54ng7m92	397	23	dependent	dependent	JJ
cord-262445-54ng7m92	397	24	protein	protein	NN
cord-262445-54ng7m92	397	25	degradation	degradation	NN
cord-262445-54ng7m92	397	26	.	.	.
cord-262445-54ng7m92	398	1	Furthermore	furthermore	RB
cord-262445-54ng7m92	398	2	,	,	,
cord-262445-54ng7m92	398	3	while	while	IN
cord-262445-54ng7m92	398	4	Chrnε	Chrnε	NNP
cord-262445-54ng7m92	398	5	transcription	transcription	NN
cord-262445-54ng7m92	398	6	was	be	VBD
cord-262445-54ng7m92	398	7	significantly	significantly	RB
cord-262445-54ng7m92	398	8	decreased	decrease	VBN
cord-262445-54ng7m92	398	9	during	during	IN
cord-262445-54ng7m92	398	10	aging	age	VBG
cord-262445-54ng7m92	398	11	revealing	reveal	VBG
cord-262445-54ng7m92	398	12	an	an	DT
cord-262445-54ng7m92	398	13	alteration	alteration	NN
cord-262445-54ng7m92	398	14	of	of	IN
cord-262445-54ng7m92	398	15	NMJ	NMJ	NNP
cord-262445-54ng7m92	398	16	,	,	,
cord-262445-54ng7m92	398	17	rGdf5	rGdf5	NNP
cord-262445-54ng7m92	398	18	administration	administration	NN
cord-262445-54ng7m92	398	19	led	lead	VBD
cord-262445-54ng7m92	398	20	to	to	IN
cord-262445-54ng7m92	398	21	Chrnε	Chrnε	NNP
cord-262445-54ng7m92	398	22	re	re	NN
cord-262445-54ng7m92	398	23	-	-	NN
cord-262445-54ng7m92	398	24	expression	expression	NN
cord-262445-54ng7m92	398	25	suggesting	suggest	VBG
cord-262445-54ng7m92	398	26	an	an	DT
cord-262445-54ng7m92	398	27	improvement	improvement	NN
cord-262445-54ng7m92	398	28	of	of	IN
cord-262445-54ng7m92	398	29	NMJ	NMJ	NNP
cord-262445-54ng7m92	398	30	state	state	NN
cord-262445-54ng7m92	398	31	.	.	.
cord-262445-54ng7m92	399	1	All	all	RB
cord-262445-54ng7m92	399	2	together	together	RB
cord-262445-54ng7m92	399	3	these	these	DT
cord-262445-54ng7m92	399	4	data	datum	NNS
cord-262445-54ng7m92	399	5	show	show	VBP
cord-262445-54ng7m92	399	6	that	that	IN
cord-262445-54ng7m92	399	7	rGdf5	rGdf5	NNP
cord-262445-54ng7m92	399	8	implementation	implementation	NN
cord-262445-54ng7m92	399	9	efficiently	efficiently	RB
cord-262445-54ng7m92	399	10	counteracts	counteract	VBZ
cord-262445-54ng7m92	399	11	age	age	NN
cord-262445-54ng7m92	399	12	-	-	HYPH
cord-262445-54ng7m92	399	13	related	relate	VBN
cord-262445-54ng7m92	399	14	muscle	muscle	NN
cord-262445-54ng7m92	399	15	wasting	wasting	NN
cord-262445-54ng7m92	399	16	and	and	CC
cord-262445-54ng7m92	399	17	,	,	,
cord-262445-54ng7m92	399	18	more	more	RBR
cord-262445-54ng7m92	399	19	generally	generally	RB
cord-262445-54ng7m92	399	20	,	,	,
cord-262445-54ng7m92	399	21	could	could	MD
cord-262445-54ng7m92	399	22	ameliorate	ameliorate	VB
cord-262445-54ng7m92	399	23	neuromuscular	neuromuscular	JJ
cord-262445-54ng7m92	399	24	decline	decline	NN
cord-262445-54ng7m92	399	25	and	and	CC
cord-262445-54ng7m92	399	26	protein	protein	NN
cord-262445-54ng7m92	399	27	degradation	degradation	NN
cord-262445-54ng7m92	399	28	underlying	underlie	VBG
cord-262445-54ng7m92	399	29	several	several	JJ
cord-262445-54ng7m92	399	30	(	(	-LRB-
cord-262445-54ng7m92	399	31	neuro	neuro	NNP
cord-262445-54ng7m92	399	32	)	)	-RRB-
cord-262445-54ng7m92	399	33	muscular	muscular	JJ
cord-262445-54ng7m92	399	34	diseases	disease	NNS
cord-262445-54ng7m92	399	35	.	.	.
cord-262445-54ng7m92	400	1	Cachexia	cachexia	NN
cord-262445-54ng7m92	400	2	is	be	VBZ
cord-262445-54ng7m92	400	3	a	a	DT
cord-262445-54ng7m92	400	4	highly	highly	RB
cord-262445-54ng7m92	400	5	debilitating	debilitating	JJ
cord-262445-54ng7m92	400	6	multifactorial	multifactorial	JJ
cord-262445-54ng7m92	400	7	syndrome	syndrome	NN
cord-262445-54ng7m92	400	8	associated	associate	VBN
cord-262445-54ng7m92	400	9	with	with	IN
cord-262445-54ng7m92	400	10	various	various	JJ
cord-262445-54ng7m92	400	11	diseases	disease	NNS
cord-262445-54ng7m92	400	12	and	and	CC
cord-262445-54ng7m92	400	13	is	be	VBZ
cord-262445-54ng7m92	400	14	characterized	characterize	VBN
cord-262445-54ng7m92	400	15	by	by	IN
cord-262445-54ng7m92	400	16	severe	severe	JJ
cord-262445-54ng7m92	400	17	muscle	muscle	NN
cord-262445-54ng7m92	400	18	wasting	waste	VBG
cord-262445-54ng7m92	400	19	leading	lead	VBG
cord-262445-54ng7m92	400	20	to	to	IN
cord-262445-54ng7m92	400	21	pronounced	pronounced	JJ
cord-262445-54ng7m92	400	22	weight	weight	NN
cord-262445-54ng7m92	400	23	loss	loss	NN
cord-262445-54ng7m92	400	24	,	,	,
cord-262445-54ng7m92	400	25	impaired	impaired	JJ
cord-262445-54ng7m92	400	26	quality	quality	NN
cord-262445-54ng7m92	400	27	of	of	IN
cord-262445-54ng7m92	400	28	life	life	NN
cord-262445-54ng7m92	400	29	,	,	,
cord-262445-54ng7m92	400	30	reduced	reduce	VBN
cord-262445-54ng7m92	400	31	response	response	NN
cord-262445-54ng7m92	400	32	to	to	IN
cord-262445-54ng7m92	400	33	therapy	therapy	NN
cord-262445-54ng7m92	400	34	,	,	,
cord-262445-54ng7m92	400	35	and	and	CC
cord-262445-54ng7m92	400	36	premature	premature	JJ
cord-262445-54ng7m92	400	37	death	death	NN
cord-262445-54ng7m92	400	38	.	.	.
cord-262445-54ng7m92	401	1	Vitamin	vitamin	NN
cord-262445-54ng7m92	401	2	D	d	NN
cord-262445-54ng7m92	401	3	binding	bind	VBG
cord-262445-54ng7m92	401	4	protein	protein	NN
cord-262445-54ng7m92	401	5	(	(	-LRB-
cord-262445-54ng7m92	401	6	VDBP	VDBP	NNP
cord-262445-54ng7m92	401	7	)	)	-RRB-
cord-262445-54ng7m92	401	8	,	,	,
cord-262445-54ng7m92	401	9	also	also	RB
cord-262445-54ng7m92	401	10	known	know	VBN
cord-262445-54ng7m92	401	11	as	as	IN
cord-262445-54ng7m92	401	12	Group	group	NN
cord-262445-54ng7m92	401	13	-	-	HYPH
cord-262445-54ng7m92	401	14	specific	specific	JJ
cord-262445-54ng7m92	401	15	component	component	NN
cord-262445-54ng7m92	401	16	(	(	-LRB-
cord-262445-54ng7m92	401	17	Gc	Gc	NNP
cord-262445-54ng7m92	401	18	-	-	HYPH
cord-262445-54ng7m92	401	19	globulin	globulin	NNP
cord-262445-54ng7m92	401	20	)	)	-RRB-
cord-262445-54ng7m92	401	21	,	,	,
cord-262445-54ng7m92	401	22	is	be	VBZ
cord-262445-54ng7m92	401	23	a	a	DT
cord-262445-54ng7m92	401	24	multifunctional	multifunctional	JJ
cord-262445-54ng7m92	401	25	serum	serum	NN
cord-262445-54ng7m92	401	26	glycoprotein	glycoprotein	NN
cord-262445-54ng7m92	401	27	synthesized	synthesize	VBN
cord-262445-54ng7m92	401	28	by	by	IN
cord-262445-54ng7m92	401	29	hepatocytes	hepatocyte	NNS
cord-262445-54ng7m92	401	30	that	that	WDT
cord-262445-54ng7m92	401	31	belongs	belong	VBZ
cord-262445-54ng7m92	401	32	to	to	IN
cord-262445-54ng7m92	401	33	the	the	DT
cord-262445-54ng7m92	401	34	albumin	albumin	NN
cord-262445-54ng7m92	401	35	gene	gene	NN
cord-262445-54ng7m92	401	36	family	family	NN
cord-262445-54ng7m92	401	37	.	.	.
cord-262445-54ng7m92	402	1	Besides	besides	IN
cord-262445-54ng7m92	402	2	the	the	DT
cord-262445-54ng7m92	402	3	binding	binding	NN
cord-262445-54ng7m92	402	4	and	and	CC
cord-262445-54ng7m92	402	5	transport	transport	NN
cord-262445-54ng7m92	402	6	of	of	IN
cord-262445-54ng7m92	402	7	vitamin	vitamin	NN
cord-262445-54ng7m92	402	8	D	d	NN
cord-262445-54ng7m92	402	9	metabolites	metabolite	NNS
cord-262445-54ng7m92	402	10	in	in	IN
cord-262445-54ng7m92	402	11	blood	blood	NN
cord-262445-54ng7m92	402	12	,	,	,
cord-262445-54ng7m92	402	13	VDBP	VDBP	NNP
cord-262445-54ng7m92	402	14	has	have	VBZ
cord-262445-54ng7m92	402	15	other	other	JJ
cord-262445-54ng7m92	402	16	activities	activity	NNS
cord-262445-54ng7m92	402	17	,	,	,
cord-262445-54ng7m92	402	18	including	include	VBG
cord-262445-54ng7m92	402	19	binding	binding	NN
cord-262445-54ng7m92	402	20	and	and	CC
cord-262445-54ng7m92	402	21	clearance	clearance	NN
cord-262445-54ng7m92	402	22	of	of	IN
cord-262445-54ng7m92	402	23	monomeric	monomeric	JJ
cord-262445-54ng7m92	402	24	G	g	NN
cord-262445-54ng7m92	402	25	-	-	HYPH
cord-262445-54ng7m92	402	26	actin	actin	NN
cord-262445-54ng7m92	402	27	released	release	VBN
cord-262445-54ng7m92	402	28	from	from	IN
cord-262445-54ng7m92	402	29	dead	dead	JJ
cord-262445-54ng7m92	402	30	cells	cell	NNS
cord-262445-54ng7m92	402	31	and	and	CC
cord-262445-54ng7m92	402	32	acting	act	VBG
cord-262445-54ng7m92	402	33	as	as	IN
cord-262445-54ng7m92	402	34	a	a	DT
cord-262445-54ng7m92	402	35	chemotactic	chemotactic	JJ
cord-262445-54ng7m92	402	36	cofactor	cofactor	NN
cord-262445-54ng7m92	402	37	for	for	IN
cord-262445-54ng7m92	402	38	C5a	C5a	NNS
cord-262445-54ng7m92	402	39	.	.	.
cord-262445-54ng7m92	403	1	Proteomic	proteomic	JJ
cord-262445-54ng7m92	403	2	analysis	analysis	NN
cord-262445-54ng7m92	403	3	of	of	IN
cord-262445-54ng7m92	403	4	samples	sample	NNS
cord-262445-54ng7m92	403	5	from	from	IN
cord-262445-54ng7m92	403	6	patients	patient	NNS
cord-262445-54ng7m92	403	7	affected	affect	VBN
cord-262445-54ng7m92	403	8	by	by	IN
cord-262445-54ng7m92	403	9	pathologies	pathology	NNS
cord-262445-54ng7m92	403	10	susceptible	susceptible	JJ
cord-262445-54ng7m92	403	11	to	to	IN
cord-262445-54ng7m92	403	12	progressive	progressive	JJ
cord-262445-54ng7m92	403	13	muscle	muscle	NN
cord-262445-54ng7m92	403	14	loss	loss	NN
cord-262445-54ng7m92	403	15	or	or	CC
cord-262445-54ng7m92	403	16	cachexia	cachexia	NN
cord-262445-54ng7m92	403	17	,	,	,
cord-262445-54ng7m92	403	18	including	include	VBG
cord-262445-54ng7m92	403	19	several	several	JJ
cord-262445-54ng7m92	403	20	types	type	NNS
cord-262445-54ng7m92	403	21	of	of	IN
cord-262445-54ng7m92	403	22	cancers	cancer	NNS
cord-262445-54ng7m92	403	23	,	,	,
cord-262445-54ng7m92	403	24	shows	show	VBZ
cord-262445-54ng7m92	403	25	upregulation	upregulation	NN
cord-262445-54ng7m92	403	26	of	of	IN
cord-262445-54ng7m92	403	27	vitamin	vitamin	NN
cord-262445-54ng7m92	403	28	D	d	NN
cord-262445-54ng7m92	403	29	binding	bind	VBG
cord-262445-54ng7m92	403	30	protein	protein	NN
cord-262445-54ng7m92	403	31	(	(	-LRB-
cord-262445-54ng7m92	403	32	VDBP	VDBP	NNP
cord-262445-54ng7m92	403	33	)	)	-RRB-
cord-262445-54ng7m92	403	34	,	,	,
cord-262445-54ng7m92	403	35	raising	raise	VBG
cord-262445-54ng7m92	403	36	the	the	DT
cord-262445-54ng7m92	403	37	hypothesis	hypothesis	NN
cord-262445-54ng7m92	403	38	that	that	IN
cord-262445-54ng7m92	403	39	VDBP	VDBP	NNP
cord-262445-54ng7m92	403	40	might	may	MD
cord-262445-54ng7m92	403	41	play	play	VB
cord-262445-54ng7m92	403	42	a	a	DT
cord-262445-54ng7m92	403	43	role	role	NN
cord-262445-54ng7m92	403	44	in	in	IN
cord-262445-54ng7m92	403	45	cancer	cancer	NN
cord-262445-54ng7m92	403	46	cachexia	cachexia	NN
cord-262445-54ng7m92	403	47	-	-	HYPH
cord-262445-54ng7m92	403	48	associated	associate	VBN
cord-262445-54ng7m92	403	49	muscle	muscle	NN
cord-262445-54ng7m92	403	50	loss	loss	NN
cord-262445-54ng7m92	403	51	.	.	.
cord-262445-54ng7m92	404	1	We	-PRON-	PRP
cord-262445-54ng7m92	404	2	found	find	VBD
cord-262445-54ng7m92	404	3	that	that	IN
cord-262445-54ng7m92	404	4	VDBP	VDBP	NNP
cord-262445-54ng7m92	404	5	expression	expression	NN
cord-262445-54ng7m92	404	6	increases	increase	NNS
cord-262445-54ng7m92	404	7	in	in	IN
cord-262445-54ng7m92	404	8	tumor	tumor	NN
cord-262445-54ng7m92	404	9	-	-	HYPH
cord-262445-54ng7m92	404	10	bearing	bear	VBG
cord-262445-54ng7m92	404	11	mice	mouse	NNS
cord-262445-54ng7m92	404	12	undergoing	undergo	VBG
cord-262445-54ng7m92	404	13	cachexia	cachexia	NN
cord-262445-54ng7m92	404	14	,	,	,
cord-262445-54ng7m92	404	15	further	further	RB
cord-262445-54ng7m92	404	16	supporting	support	VBG
cord-262445-54ng7m92	404	17	the	the	DT
cord-262445-54ng7m92	404	18	notion	notion	NN
cord-262445-54ng7m92	404	19	that	that	IN
cord-262445-54ng7m92	404	20	VDBP	VDBP	NNP
cord-262445-54ng7m92	404	21	could	could	MD
cord-262445-54ng7m92	404	22	play	play	VB
cord-262445-54ng7m92	404	23	a	a	DT
cord-262445-54ng7m92	404	24	role	role	NN
cord-262445-54ng7m92	404	25	in	in	IN
cord-262445-54ng7m92	404	26	the	the	DT
cord-262445-54ng7m92	404	27	onset	onset	NN
cord-262445-54ng7m92	404	28	/	/	SYM
cord-262445-54ng7m92	404	29	progression	progression	NN
cord-262445-54ng7m92	404	30	of	of	IN
cord-262445-54ng7m92	404	31	cancer	cancer	NN
cord-262445-54ng7m92	404	32	-	-	HYPH
cord-262445-54ng7m92	404	33	associated	associate	VBN
cord-262445-54ng7m92	404	34	muscle	muscle	NN
cord-262445-54ng7m92	404	35	wasting	wasting	NN
cord-262445-54ng7m92	404	36	.	.	.
cord-262445-54ng7m92	405	1	We	-PRON-	PRP
cord-262445-54ng7m92	405	2	explored	explore	VBD
cord-262445-54ng7m92	405	3	the	the	DT
cord-262445-54ng7m92	405	4	direct	direct	JJ
cord-262445-54ng7m92	405	5	action	action	NN
cord-262445-54ng7m92	405	6	of	of	IN
cord-262445-54ng7m92	405	7	VDBP	VDBP	NNP
cord-262445-54ng7m92	405	8	in	in	IN
cord-262445-54ng7m92	405	9	skeletal	skeletal	JJ
cord-262445-54ng7m92	405	10	muscle	muscle	NN
cord-262445-54ng7m92	405	11	and	and	CC
cord-262445-54ng7m92	405	12	found	find	VBD
cord-262445-54ng7m92	405	13	that	that	IN
cord-262445-54ng7m92	405	14	VDBP	VDBP	NNP
cord-262445-54ng7m92	405	15	indeed	indeed	RB
cord-262445-54ng7m92	405	16	induces	induce	VBZ
cord-262445-54ng7m92	405	17	atrophy	atrophy	NN
cord-262445-54ng7m92	405	18	in	in	IN
cord-262445-54ng7m92	405	19	C2C12	c2c12	JJ
cord-262445-54ng7m92	405	20	myotubes	myotube	NNS
cord-262445-54ng7m92	405	21	and	and	CC
cord-262445-54ng7m92	405	22	that	that	IN
cord-262445-54ng7m92	405	23	mice	mice	NN
cord-262445-54ng7m92	405	24	devoid	devoid	JJ
cord-262445-54ng7m92	405	25	of	of	IN
cord-262445-54ng7m92	405	26	VDBP	VDBP	NNP
cord-262445-54ng7m92	405	27	are	be	VBP
cord-262445-54ng7m92	405	28	protected	protect	VBN
cord-262445-54ng7m92	405	29	from	from	IN
cord-262445-54ng7m92	405	30	cancer	cancer	NN
cord-262445-54ng7m92	405	31	-	-	HYPH
cord-262445-54ng7m92	405	32	associated	associate	VBN
cord-262445-54ng7m92	405	33	cachexia	cachexia	NN
cord-262445-54ng7m92	405	34	.	.	.
cord-262445-54ng7m92	406	1	Our	-PRON-	PRP$
cord-262445-54ng7m92	406	2	preliminary	preliminary	JJ
cord-262445-54ng7m92	406	3	results	result	NNS
cord-262445-54ng7m92	406	4	demonstrate	demonstrate	VBP
cord-262445-54ng7m92	406	5	that	that	IN
cord-262445-54ng7m92	406	6	VDBP	VDBP	NNP
cord-262445-54ng7m92	406	7	is	be	VBZ
cord-262445-54ng7m92	406	8	not	not	RB
cord-262445-54ng7m92	406	9	a	a	DT
cord-262445-54ng7m92	406	10	simple	simple	JJ
cord-262445-54ng7m92	406	11	carrier	carrier	NN
cord-262445-54ng7m92	406	12	that	that	WDT
cord-262445-54ng7m92	406	13	modulates	modulate	VBZ
cord-262445-54ng7m92	406	14	the	the	DT
cord-262445-54ng7m92	406	15	bioavailability	bioavailability	NN
cord-262445-54ng7m92	406	16	of	of	IN
cord-262445-54ng7m92	406	17	vitamin	vitamin	NN
cord-262445-54ng7m92	406	18	D	d	NN
cord-262445-54ng7m92	406	19	but	but	CC
cord-262445-54ng7m92	406	20	an	an	DT
cord-262445-54ng7m92	406	21	active	active	JJ
cord-262445-54ng7m92	406	22	hormone	hormone	NN
cord-262445-54ng7m92	406	23	in	in	IN
cord-262445-54ng7m92	406	24	itself	-PRON-	PRP
cord-262445-54ng7m92	406	25	with	with	IN
cord-262445-54ng7m92	406	26	pro	pro	JJ
cord-262445-54ng7m92	406	27	-	-	JJ
cord-262445-54ng7m92	406	28	cachectic	cachectic	JJ
cord-262445-54ng7m92	406	29	effects	effect	NNS
cord-262445-54ng7m92	406	30	on	on	IN
cord-262445-54ng7m92	406	31	skeletal	skeletal	JJ
cord-262445-54ng7m92	406	32	muscle	muscle	NN
cord-262445-54ng7m92	406	33	Cancer	cancer	NN
cord-262445-54ng7m92	406	34	cachexia	cachexia	NN
cord-262445-54ng7m92	406	35	is	be	VBZ
cord-262445-54ng7m92	406	36	a	a	DT
cord-262445-54ng7m92	406	37	devasting	devasting	JJ
cord-262445-54ng7m92	406	38	multifactorial	multifactorial	JJ
cord-262445-54ng7m92	406	39	syndrome	syndrome	NN
cord-262445-54ng7m92	406	40	characterized	characterize	VBN
cord-262445-54ng7m92	406	41	by	by	IN
cord-262445-54ng7m92	406	42	the	the	DT
cord-262445-54ng7m92	406	43	progressive	progressive	JJ
cord-262445-54ng7m92	406	44	unintentional	unintentional	JJ
cord-262445-54ng7m92	406	45	body	body	NN
cord-262445-54ng7m92	406	46	weight	weight	NN
cord-262445-54ng7m92	406	47	loss	loss	NN
cord-262445-54ng7m92	406	48	mainly	mainly	RB
cord-262445-54ng7m92	406	49	due	due	JJ
cord-262445-54ng7m92	406	50	to	to	IN
cord-262445-54ng7m92	406	51	skeletal	skeletal	JJ
cord-262445-54ng7m92	406	52	muscle	muscle	NN
cord-262445-54ng7m92	406	53	wasting	wasting	NN
cord-262445-54ng7m92	406	54	and	and	CC
cord-262445-54ng7m92	406	55	atrophy	atrophy	NN
cord-262445-54ng7m92	406	56	that	that	WDT
cord-262445-54ng7m92	406	57	occurs	occur	VBZ
cord-262445-54ng7m92	406	58	in	in	IN
cord-262445-54ng7m92	406	59	the	the	DT
cord-262445-54ng7m92	406	60	majority	majority	NN
cord-262445-54ng7m92	406	61	of	of	IN
cord-262445-54ng7m92	406	62	terminally	terminally	RB
cord-262445-54ng7m92	406	63	-	-	HYPH
cord-262445-54ng7m92	406	64	ill	ill	JJ
cord-262445-54ng7m92	406	65	cancer	cancer	NN
cord-262445-54ng7m92	406	66	patients	patient	NNS
cord-262445-54ng7m92	406	67	.	.	.
cord-262445-54ng7m92	407	1	Notably	notably	RB
cord-262445-54ng7m92	407	2	,	,	,
cord-262445-54ng7m92	407	3	cancer	cancer	NN
cord-262445-54ng7m92	407	4	-	-	HYPH
cord-262445-54ng7m92	407	5	induced	induce	VBN
cord-262445-54ng7m92	407	6	muscle	muscle	NN
cord-262445-54ng7m92	407	7	wasting	waste	VBG
cord-262445-54ng7m92	407	8	markedly	markedly	RB
cord-262445-54ng7m92	407	9	results	result	VBZ
cord-262445-54ng7m92	407	10	in	in	IN
cord-262445-54ng7m92	407	11	a	a	DT
cord-262445-54ng7m92	407	12	drastic	drastic	JJ
cord-262445-54ng7m92	407	13	worsening	worsening	NN
cord-262445-54ng7m92	407	14	of	of	IN
cord-262445-54ng7m92	407	15	patient	patient	JJ
cord-262445-54ng7m92	407	16	prognosis	prognosis	NN
cord-262445-54ng7m92	407	17	and	and	CC
cord-262445-54ng7m92	407	18	quality	quality	NN
cord-262445-54ng7m92	407	19	of	of	IN
cord-262445-54ng7m92	407	20	life	life	NN
cord-262445-54ng7m92	407	21	.	.	.
cord-262445-54ng7m92	408	1	Furthermore	furthermore	RB
cord-262445-54ng7m92	408	2	,	,	,
cord-262445-54ng7m92	408	3	cancer	cancer	NN
cord-262445-54ng7m92	408	4	-	-	HYPH
cord-262445-54ng7m92	408	5	driven	drive	VBN
cord-262445-54ng7m92	408	6	cachexia	cachexia	NN
cord-262445-54ng7m92	408	7	also	also	RB
cord-262445-54ng7m92	408	8	limits	limit	VBZ
cord-262445-54ng7m92	408	9	the	the	DT
cord-262445-54ng7m92	408	10	therapeutic	therapeutic	JJ
cord-262445-54ng7m92	408	11	options	option	NNS
cord-262445-54ng7m92	408	12	,	,	,
cord-262445-54ng7m92	408	13	as	as	IN
cord-262445-54ng7m92	408	14	cachectic	cachectic	JJ
cord-262445-54ng7m92	408	15	patients	patient	NNS
cord-262445-54ng7m92	408	16	usually	usually	RB
cord-262445-54ng7m92	408	17	manifest	manifest	VBP
cord-262445-54ng7m92	408	18	reduced	reduce	VBN
cord-262445-54ng7m92	408	19	tolerance	tolerance	NN
cord-262445-54ng7m92	408	20	and	and	CC
cord-262445-54ng7m92	408	21	response	response	NN
cord-262445-54ng7m92	408	22	to	to	IN
cord-262445-54ng7m92	408	23	antineoplastic	antineoplastic	JJ
cord-262445-54ng7m92	408	24	treatments	treatment	NNS
cord-262445-54ng7m92	408	25	.	.	.
cord-262445-54ng7m92	409	1	Aside	aside	RB
cord-262445-54ng7m92	409	2	from	from	IN
cord-262445-54ng7m92	409	3	this	this	DT
cord-262445-54ng7m92	409	4	,	,	,
cord-262445-54ng7m92	409	5	cachexia	cachexia	NN
cord-262445-54ng7m92	409	6	directly	directly	RB
cord-262445-54ng7m92	409	7	accounts	account	VBZ
cord-262445-54ng7m92	409	8	for	for	IN
cord-262445-54ng7m92	409	9	nearly	nearly	RB
cord-262445-54ng7m92	409	10	20	20	CD
cord-262445-54ng7m92	409	11	%	%	NN
cord-262445-54ng7m92	409	12	of	of	IN
cord-262445-54ng7m92	409	13	all	all	DT
cord-262445-54ng7m92	409	14	cancer	cancer	NN
cord-262445-54ng7m92	409	15	-	-	HYPH
cord-262445-54ng7m92	409	16	related	relate	VBN
cord-262445-54ng7m92	409	17	deaths	death	NNS
cord-262445-54ng7m92	409	18	,	,	,
cord-262445-54ng7m92	409	19	as	as	IN
cord-262445-54ng7m92	409	20	the	the	DT
cord-262445-54ng7m92	409	21	cachectic	cachectic	JJ
cord-262445-54ng7m92	409	22	skeletal	skeletal	JJ
cord-262445-54ng7m92	409	23	muscle	muscle	NN
cord-262445-54ng7m92	409	24	wasting	waste	VBG
cord-262445-54ng7m92	409	25	also	also	RB
cord-262445-54ng7m92	409	26	affects	affect	VBZ
cord-262445-54ng7m92	409	27	survival	survival	NN
cord-262445-54ng7m92	409	28	needed	need	VBD
cord-262445-54ng7m92	409	29	muscles	muscle	NNS
cord-262445-54ng7m92	409	30	such	such	JJ
cord-262445-54ng7m92	409	31	as	as	IN
cord-262445-54ng7m92	409	32	diaphragm	diaphragm	NN
cord-262445-54ng7m92	409	33	and	and	CC
cord-262445-54ng7m92	409	34	cardiac	cardiac	JJ
cord-262445-54ng7m92	409	35	muscle	muscle	NN
cord-262445-54ng7m92	409	36	,	,	,
cord-262445-54ng7m92	409	37	leading	lead	VBG
cord-262445-54ng7m92	409	38	to	to	IN
cord-262445-54ng7m92	409	39	respiratory	respiratory	JJ
cord-262445-54ng7m92	409	40	and	and	CC
cord-262445-54ng7m92	409	41	cardiac	cardiac	JJ
cord-262445-54ng7m92	409	42	failure	failure	NN
cord-262445-54ng7m92	409	43	.	.	.
cord-262445-54ng7m92	410	1	In	in	IN
cord-262445-54ng7m92	410	2	the	the	DT
cord-262445-54ng7m92	410	3	last	last	JJ
cord-262445-54ng7m92	410	4	decade	decade	NN
cord-262445-54ng7m92	410	5	,	,	,
cord-262445-54ng7m92	410	6	the	the	DT
cord-262445-54ng7m92	410	7	pivotal	pivotal	JJ
cord-262445-54ng7m92	410	8	role	role	NN
cord-262445-54ng7m92	410	9	of	of	IN
cord-262445-54ng7m92	410	10	cancer	cancer	NN
cord-262445-54ng7m92	410	11	-	-	HYPH
cord-262445-54ng7m92	410	12	driven	drive	VBN
cord-262445-54ng7m92	410	13	inflammation	inflammation	NN
cord-262445-54ng7m92	410	14	both	both	CC
cord-262445-54ng7m92	410	15	in	in	IN
cord-262445-54ng7m92	410	16	tumour	tumour	NN
cord-262445-54ng7m92	410	17	progression	progression	NN
cord-262445-54ng7m92	410	18	and	and	CC
cord-262445-54ng7m92	410	19	cachexia	cachexia	NN
cord-262445-54ng7m92	410	20	onset	onset	NN
cord-262445-54ng7m92	410	21	has	have	VBZ
cord-262445-54ng7m92	410	22	clearly	clearly	RB
cord-262445-54ng7m92	410	23	emerged	emerge	VBN
cord-262445-54ng7m92	410	24	,	,	,
cord-262445-54ng7m92	410	25	as	as	RB
cord-262445-54ng7m92	410	26	well	well	RB
cord-262445-54ng7m92	410	27	as	as	IN
cord-262445-54ng7m92	410	28	cancer	cancer	NN
cord-262445-54ng7m92	410	29	cachexia	cachexia	NN
cord-262445-54ng7m92	410	30	is	be	VBZ
cord-262445-54ng7m92	410	31	associated	associate	VBN
cord-262445-54ng7m92	410	32	to	to	IN
cord-262445-54ng7m92	410	33	a	a	DT
cord-262445-54ng7m92	410	34	broad	broad	JJ
cord-262445-54ng7m92	410	35	range	range	NN
cord-262445-54ng7m92	410	36	of	of	IN
cord-262445-54ng7m92	410	37	metabolic	metabolic	JJ
cord-262445-54ng7m92	410	38	and	and	CC
cord-262445-54ng7m92	410	39	endocrine	endocrine	JJ
cord-262445-54ng7m92	410	40	impairments	impairment	NNS
cord-262445-54ng7m92	410	41	leading	lead	VBG
cord-262445-54ng7m92	410	42	to	to	IN
cord-262445-54ng7m92	410	43	tissue	tissue	NN
cord-262445-54ng7m92	410	44	function	function	NN
cord-262445-54ng7m92	410	45	disruptions	disruption	NNS
cord-262445-54ng7m92	410	46	.	.	.
cord-262445-54ng7m92	411	1	Nevertheless	nevertheless	RB
cord-262445-54ng7m92	411	2	,	,	,
cord-262445-54ng7m92	411	3	the	the	DT
cord-262445-54ng7m92	411	4	potential	potential	JJ
cord-262445-54ng7m92	411	5	role	role	NN
cord-262445-54ng7m92	411	6	of	of	IN
cord-262445-54ng7m92	411	7	muscle	muscle	NN
cord-262445-54ng7m92	411	8	metabolic	metabolic	JJ
cord-262445-54ng7m92	411	9	alterations	alteration	NNS
cord-262445-54ng7m92	411	10	in	in	IN
cord-262445-54ng7m92	411	11	the	the	DT
cord-262445-54ng7m92	411	12	activation	activation	NN
cord-262445-54ng7m92	411	13	and	and	CC
cord-262445-54ng7m92	411	14	development	development	NN
cord-262445-54ng7m92	411	15	of	of	IN
cord-262445-54ng7m92	411	16	cancer	cancer	NN
cord-262445-54ng7m92	411	17	cachexia	cachexia	NN
cord-262445-54ng7m92	411	18	has	have	VBZ
cord-262445-54ng7m92	411	19	been	be	VBN
cord-262445-54ng7m92	411	20	little	little	RB
cord-262445-54ng7m92	411	21	studied	study	VBN
cord-262445-54ng7m92	411	22	so	so	RB
cord-262445-54ng7m92	411	23	far	far	RB
cord-262445-54ng7m92	411	24	.	.	.
cord-262445-54ng7m92	412	1	Here	here	RB
cord-262445-54ng7m92	412	2	,	,	,
cord-262445-54ng7m92	412	3	we	-PRON-	PRP
cord-262445-54ng7m92	412	4	report	report	VBP
cord-262445-54ng7m92	412	5	that	that	IN
cord-262445-54ng7m92	412	6	conditioned	condition	VBN
cord-262445-54ng7m92	412	7	media	medium	NNS
cord-262445-54ng7m92	412	8	(	(	-LRB-
cord-262445-54ng7m92	412	9	CM	CM	NNP
cord-262445-54ng7m92	412	10	)	)	-RRB-
cord-262445-54ng7m92	412	11	from	from	IN
cord-262445-54ng7m92	412	12	murine	murine	JJ
cord-262445-54ng7m92	412	13	and	and	CC
cord-262445-54ng7m92	412	14	human	human	JJ
cord-262445-54ng7m92	412	15	carcinoma	carcinoma	NN
cord-262445-54ng7m92	412	16	cell	cell	NN
cord-262445-54ng7m92	412	17	lines	line	NNS
cord-262445-54ng7m92	412	18	able	able	JJ
cord-262445-54ng7m92	412	19	to	to	TO
cord-262445-54ng7m92	412	20	trigger	trigger	VB
cord-262445-54ng7m92	412	21	cachexia	cachexia	NN
cord-262445-54ng7m92	412	22	in	in	IN
cord-262445-54ng7m92	412	23	vivo	vivo	NN
cord-262445-54ng7m92	412	24	,	,	,
cord-262445-54ng7m92	412	25	induce	induce	VBP
cord-262445-54ng7m92	412	26	cachexia	cachexia	NN
cord-262445-54ng7m92	412	27	in	in	IN
cord-262445-54ng7m92	412	28	C2C12	c2c12	JJ
cord-262445-54ng7m92	412	29	myotubes	myotube	NNS
cord-262445-54ng7m92	412	30	that	that	WDT
cord-262445-54ng7m92	412	31	is	be	VBZ
cord-262445-54ng7m92	412	32	associated	associate	VBN
cord-262445-54ng7m92	412	33	to	to	IN
cord-262445-54ng7m92	412	34	a	a	DT
cord-262445-54ng7m92	412	35	metabolic	metabolic	JJ
cord-262445-54ng7m92	412	36	shift	shift	NN
cord-262445-54ng7m92	412	37	towards	towards	IN
cord-262445-54ng7m92	412	38	fermentation	fermentation	NN
cord-262445-54ng7m92	412	39	.	.	.
cord-262445-54ng7m92	413	1	Our	-PRON-	PRP$
cord-262445-54ng7m92	413	2	findings	finding	NNS
cord-262445-54ng7m92	413	3	suggest	suggest	VBP
cord-262445-54ng7m92	413	4	that	that	IN
cord-262445-54ng7m92	413	5	this	this	DT
cord-262445-54ng7m92	413	6	metabolic	metabolic	JJ
cord-262445-54ng7m92	413	7	shift	shift	NN
cord-262445-54ng7m92	413	8	is	be	VBZ
cord-262445-54ng7m92	413	9	crucially	crucially	RB
cord-262445-54ng7m92	413	10	involved	involve	VBN
cord-262445-54ng7m92	413	11	in	in	IN
cord-262445-54ng7m92	413	12	the	the	DT
cord-262445-54ng7m92	413	13	activation	activation	NN
cord-262445-54ng7m92	413	14	of	of	IN
cord-262445-54ng7m92	413	15	cachexia	cachexia	NN
cord-262445-54ng7m92	413	16	in	in	IN
cord-262445-54ng7m92	413	17	C2C12	c2c12	JJ
cord-262445-54ng7m92	413	18	myotubes	myotube	NNS
cord-262445-54ng7m92	413	19	,	,	,
cord-262445-54ng7m92	413	20	since	since	IN
cord-262445-54ng7m92	413	21	the	the	DT
cord-262445-54ng7m92	413	22	abolishment	abolishment	NN
cord-262445-54ng7m92	413	23	through	through	IN
cord-262445-54ng7m92	413	24	glycolysis	glycolysis	NN
cord-262445-54ng7m92	413	25	block	block	NN
cord-262445-54ng7m92	413	26	or	or	CC
cord-262445-54ng7m92	413	27	lactate	lactate	NN
cord-262445-54ng7m92	413	28	dehydrogenase	dehydrogenase	NN
cord-262445-54ng7m92	413	29	inhibition	inhibition	NN
cord-262445-54ng7m92	413	30	,	,	,
cord-262445-54ng7m92	413	31	prevents	prevent	VBZ
cord-262445-54ng7m92	413	32	the	the	DT
cord-262445-54ng7m92	413	33	onset	onset	NN
cord-262445-54ng7m92	413	34	of	of	IN
cord-262445-54ng7m92	413	35	the	the	DT
cord-262445-54ng7m92	413	36	cachectic	cachectic	JJ
cord-262445-54ng7m92	413	37	phenotype	phenotype	NN
cord-262445-54ng7m92	413	38	.	.	.
cord-262445-54ng7m92	414	1	Furthermore	furthermore	RB
cord-262445-54ng7m92	414	2	,	,	,
cord-262445-54ng7m92	414	3	our	-PRON-	PRP$
cord-262445-54ng7m92	414	4	evidences	evidence	NNS
cord-262445-54ng7m92	414	5	suggest	suggest	VBP
cord-262445-54ng7m92	414	6	that	that	IN
cord-262445-54ng7m92	414	7	CM	cm	NN
cord-262445-54ng7m92	414	8	from	from	IN
cord-262445-54ng7m92	414	9	cancer	cancer	NN
cord-262445-54ng7m92	414	10	cell	cell	NN
cord-262445-54ng7m92	414	11	lines	line	NNS
cord-262445-54ng7m92	414	12	able	able	JJ
cord-262445-54ng7m92	414	13	to	to	TO
cord-262445-54ng7m92	414	14	induce	induce	VB
cord-262445-54ng7m92	414	15	cachexia	cachexia	NN
cord-262445-54ng7m92	414	16	express	express	VB
cord-262445-54ng7m92	414	17	high	high	JJ
cord-262445-54ng7m92	414	18	levels	level	NNS
cord-262445-54ng7m92	414	19	of	of	IN
cord-262445-54ng7m92	414	20	IFN	IFN	NNP
cord-262445-54ng7m92	414	21	-	-	HYPH
cord-262445-54ng7m92	414	22	γ	γ	NNP
cord-262445-54ng7m92	414	23	and	and	CC
cord-262445-54ng7m92	414	24	IL-6	IL-6	NNP
cord-262445-54ng7m92	414	25	and	and	CC
cord-262445-54ng7m92	414	26	that	that	IN
cord-262445-54ng7m92	414	27	these	these	DT
cord-262445-54ng7m92	414	28	two	two	CD
cord-262445-54ng7m92	414	29	proinflammatory	proinflammatory	JJ
cord-262445-54ng7m92	414	30	cytokines	cytokine	NNS
cord-262445-54ng7m92	414	31	could	could	MD
cord-262445-54ng7m92	414	32	be	be	VB
cord-262445-54ng7m92	414	33	involved	involve	VBN
cord-262445-54ng7m92	414	34	in	in	IN
cord-262445-54ng7m92	414	35	the	the	DT
cord-262445-54ng7m92	414	36	metabolic	metabolic	JJ
cord-262445-54ng7m92	414	37	shift	shift	NN
cord-262445-54ng7m92	414	38	towards	towards	IN
cord-262445-54ng7m92	414	39	fermentation	fermentation	NN
cord-262445-54ng7m92	414	40	that	that	WDT
cord-262445-54ng7m92	414	41	occurs	occur	VBZ
cord-262445-54ng7m92	414	42	in	in	IN
cord-262445-54ng7m92	414	43	CM	cm	NN
cord-262445-54ng7m92	414	44	-	-	HYPH
cord-262445-54ng7m92	414	45	treated	treat	VBN
cord-262445-54ng7m92	414	46	myotubes	myotube	NNS
cord-262445-54ng7m92	414	47	,	,	,
cord-262445-54ng7m92	414	48	thus	thus	RB
cord-262445-54ng7m92	414	49	leading	lead	VBG
cord-262445-54ng7m92	414	50	to	to	IN
cord-262445-54ng7m92	414	51	cachectic	cachectic	JJ
cord-262445-54ng7m92	414	52	phenotype	phenotype	NN
cord-262445-54ng7m92	414	53	.	.	.
cord-262445-54ng7m92	415	1	Overall	overall	RB
cord-262445-54ng7m92	415	2	,	,	,
cord-262445-54ng7m92	415	3	our	-PRON-	PRP$
cord-262445-54ng7m92	415	4	results	result	NNS
cord-262445-54ng7m92	415	5	show	show	VBP
cord-262445-54ng7m92	415	6	the	the	DT
cord-262445-54ng7m92	415	7	possible	possible	JJ
cord-262445-54ng7m92	415	8	key	key	JJ
cord-262445-54ng7m92	415	9	role	role	NN
cord-262445-54ng7m92	415	10	of	of	IN
cord-262445-54ng7m92	415	11	the	the	DT
cord-262445-54ng7m92	415	12	metabolic	metabolic	JJ
cord-262445-54ng7m92	415	13	reprogramming	reprogramming	NN
cord-262445-54ng7m92	415	14	towards	towards	IN
cord-262445-54ng7m92	415	15	fermentation	fermentation	NN
cord-262445-54ng7m92	415	16	in	in	IN
cord-262445-54ng7m92	415	17	the	the	DT
cord-262445-54ng7m92	415	18	induction	induction	NN
cord-262445-54ng7m92	415	19	of	of	IN
cord-262445-54ng7m92	415	20	cachexia	cachexia	NN
cord-262445-54ng7m92	415	21	in	in	IN
cord-262445-54ng7m92	415	22	myotubes	myotubes	NNP
cord-262445-54ng7m92	415	23	,	,	,
cord-262445-54ng7m92	415	24	thus	thus	RB
cord-262445-54ng7m92	415	25	opening	open	VBG
cord-262445-54ng7m92	415	26	the	the	DT
cord-262445-54ng7m92	415	27	study	study	NN
cord-262445-54ng7m92	415	28	to	to	IN
cord-262445-54ng7m92	415	29	new	new	JJ
cord-262445-54ng7m92	415	30	drugs	drug	NNS
cord-262445-54ng7m92	415	31	that	that	WDT
cord-262445-54ng7m92	415	32	could	could	MD
cord-262445-54ng7m92	415	33	counteract	counteract	VB
cord-262445-54ng7m92	415	34	the	the	DT
cord-262445-54ng7m92	415	35	metabolic	metabolic	JJ
cord-262445-54ng7m92	415	36	shift	shift	NN
cord-262445-54ng7m92	415	37	and	and	CC
cord-262445-54ng7m92	415	38	inhibit	inhibit	VB
cord-262445-54ng7m92	415	39	the	the	DT
cord-262445-54ng7m92	415	40	cachectic	cachectic	JJ
cord-262445-54ng7m92	415	41	phenotype	phenotype	NN
cord-262445-54ng7m92	415	42	.	.	.
cord-262445-54ng7m92	416	1	Aging	age	VBG
cord-262445-54ng7m92	416	2	is	be	VBZ
cord-262445-54ng7m92	416	3	associated	associate	VBN
cord-262445-54ng7m92	416	4	with	with	IN
cord-262445-54ng7m92	416	5	a	a	DT
cord-262445-54ng7m92	416	6	progressive	progressive	JJ
cord-262445-54ng7m92	416	7	loss	loss	NN
cord-262445-54ng7m92	416	8	in	in	IN
cord-262445-54ng7m92	416	9	skeletal	skeletal	JJ
cord-262445-54ng7m92	416	10	muscle	muscle	NN
cord-262445-54ng7m92	416	11	mass	mass	NN
cord-262445-54ng7m92	416	12	and	and	CC
cord-262445-54ng7m92	416	13	strength	strength	NN
cord-262445-54ng7m92	416	14	,	,	,
cord-262445-54ng7m92	416	15	known	know	VBN
cord-262445-54ng7m92	416	16	as	as	IN
cord-262445-54ng7m92	416	17	sarcopenia	sarcopenia	NN
cord-262445-54ng7m92	416	18	.	.	.
cord-262445-54ng7m92	417	1	Sarcopenia	Sarcopenia	NNP
cord-262445-54ng7m92	417	2	results	result	VBZ
cord-262445-54ng7m92	417	3	in	in	IN
cord-262445-54ng7m92	417	4	a	a	DT
cord-262445-54ng7m92	417	5	decrease	decrease	NN
cord-262445-54ng7m92	417	6	in	in	IN
cord-262445-54ng7m92	417	7	mobility	mobility	NN
cord-262445-54ng7m92	417	8	and	and	CC
cord-262445-54ng7m92	417	9	an	an	DT
cord-262445-54ng7m92	417	10	increased	increase	VBN
cord-262445-54ng7m92	417	11	risk	risk	NN
cord-262445-54ng7m92	417	12	of	of	IN
cord-262445-54ng7m92	417	13	developing	develop	VBG
cord-262445-54ng7m92	417	14	chronic	chronic	JJ
cord-262445-54ng7m92	417	15	metabolic	metabolic	JJ
cord-262445-54ng7m92	417	16	disease	disease	NN
cord-262445-54ng7m92	418	1	,	,	,
cord-262445-54ng7m92	418	2	thus	thus	RB
cord-262445-54ng7m92	418	3	it	-PRON-	PRP
cord-262445-54ng7m92	418	4	represents	represent	VBZ
cord-262445-54ng7m92	418	5	a	a	DT
cord-262445-54ng7m92	418	6	major	major	JJ
cord-262445-54ng7m92	418	7	socio	socio	JJ
cord-262445-54ng7m92	418	8	-	-	HYPH
cord-262445-54ng7m92	418	9	economical	economical	JJ
cord-262445-54ng7m92	418	10	problem	problem	NN
cord-262445-54ng7m92	418	11	.	.	.
cord-262445-54ng7m92	419	1	Age	age	NN
cord-262445-54ng7m92	419	2	-	-	HYPH
cord-262445-54ng7m92	419	3	related	relate	VBN
cord-262445-54ng7m92	419	4	muscle	muscle	NN
cord-262445-54ng7m92	419	5	loss	loss	NN
cord-262445-54ng7m92	419	6	can	can	MD
cord-262445-54ng7m92	419	7	not	not	RB
cord-262445-54ng7m92	419	8	be	be	VB
cord-262445-54ng7m92	419	9	consistently	consistently	RB
cord-262445-54ng7m92	419	10	prevented	prevent	VBN
cord-262445-54ng7m92	419	11	by	by	IN
cord-262445-54ng7m92	419	12	physical	physical	JJ
cord-262445-54ng7m92	419	13	therapy	therapy	NN
cord-262445-54ng7m92	419	14	and	and	CC
cord-262445-54ng7m92	419	15	a	a	DT
cord-262445-54ng7m92	419	16	pharmacologic	pharmacologic	JJ
cord-262445-54ng7m92	419	17	therapy	therapy	NN
cord-262445-54ng7m92	419	18	does	do	VBZ
cord-262445-54ng7m92	419	19	not	not	RB
cord-262445-54ng7m92	419	20	exist	exist	VB
cord-262445-54ng7m92	419	21	,	,	,
cord-262445-54ng7m92	419	22	probably	probably	RB
cord-262445-54ng7m92	419	23	because	because	IN
cord-262445-54ng7m92	419	24	the	the	DT
cord-262445-54ng7m92	419	25	molecular	molecular	JJ
cord-262445-54ng7m92	419	26	basis	basis	NN
cord-262445-54ng7m92	419	27	of	of	IN
cord-262445-54ng7m92	419	28	this	this	DT
cord-262445-54ng7m92	419	29	condition	condition	NN
cord-262445-54ng7m92	419	30	is	be	VBZ
cord-262445-54ng7m92	419	31	still	still	RB
cord-262445-54ng7m92	419	32	largely	largely	RB
cord-262445-54ng7m92	419	33	unknown	unknown	JJ
cord-262445-54ng7m92	419	34	.	.	.
cord-262445-54ng7m92	420	1	Many	many	JJ
cord-262445-54ng7m92	420	2	factors	factor	NNS
cord-262445-54ng7m92	420	3	such	such	JJ
cord-262445-54ng7m92	420	4	as	as	IN
cord-262445-54ng7m92	420	5	mitochondrial	mitochondrial	JJ
cord-262445-54ng7m92	420	6	dysfunction	dysfunction	NN
cord-262445-54ng7m92	420	7	,	,	,
cord-262445-54ng7m92	420	8	oxidative	oxidative	JJ
cord-262445-54ng7m92	420	9	stress	stress	NN
cord-262445-54ng7m92	420	10	,	,	,
cord-262445-54ng7m92	420	11	inflammation	inflammation	NN
cord-262445-54ng7m92	420	12	,	,	,
cord-262445-54ng7m92	420	13	changes	change	NNS
cord-262445-54ng7m92	420	14	in	in	IN
cord-262445-54ng7m92	420	15	the	the	DT
cord-262445-54ng7m92	420	16	innervation	innervation	NN
cord-262445-54ng7m92	420	17	of	of	IN
cord-262445-54ng7m92	420	18	muscle	muscle	NN
cord-262445-54ng7m92	420	19	fibers	fiber	NNS
cord-262445-54ng7m92	420	20	probably	probably	RB
cord-262445-54ng7m92	420	21	play	play	VBP
cord-262445-54ng7m92	420	22	an	an	DT
cord-262445-54ng7m92	420	23	important	important	JJ
cord-262445-54ng7m92	420	24	role	role	NN
cord-262445-54ng7m92	420	25	in	in	IN
cord-262445-54ng7m92	420	26	age	age	NN
cord-262445-54ng7m92	420	27	-	-	HYPH
cord-262445-54ng7m92	420	28	related	relate	VBN
cord-262445-54ng7m92	420	29	muscle	muscle	NN
cord-262445-54ng7m92	420	30	decline	decline	NN
cord-262445-54ng7m92	420	31	.	.	.
cord-262445-54ng7m92	421	1	PIN1	PIN1	NNP
cord-262445-54ng7m92	421	2	is	be	VBZ
cord-262445-54ng7m92	421	3	a	a	DT
cord-262445-54ng7m92	421	4	widely	widely	RB
cord-262445-54ng7m92	421	5	expressed	express	VBN
cord-262445-54ng7m92	421	6	Peptydyl	Peptydyl	NNP
cord-262445-54ng7m92	421	7	Prolyl	Prolyl	NNP
cord-262445-54ng7m92	421	8	cis	cis	NNP
cord-262445-54ng7m92	421	9	/	/	SYM
cord-262445-54ng7m92	421	10	trans	trans	NNP
cord-262445-54ng7m92	421	11	isomerase	isomerase	NN
cord-262445-54ng7m92	421	12	,	,	,
cord-262445-54ng7m92	421	13	involved	involve	VBN
cord-262445-54ng7m92	421	14	in	in	IN
cord-262445-54ng7m92	421	15	post	post	JJ
cord-262445-54ng7m92	421	16	-	-	JJ
cord-262445-54ng7m92	421	17	phosphorylation	phosphorylation	JJ
cord-262445-54ng7m92	421	18	control	control	NN
cord-262445-54ng7m92	421	19	of	of	IN
cord-262445-54ng7m92	421	20	the	the	DT
cord-262445-54ng7m92	421	21	function	function	NN
cord-262445-54ng7m92	421	22	of	of	IN
cord-262445-54ng7m92	421	23	multiple	multiple	JJ
cord-262445-54ng7m92	421	24	target	target	NN
cord-262445-54ng7m92	421	25	proteins	protein	NNS
cord-262445-54ng7m92	421	26	.	.	.
cord-262445-54ng7m92	422	1	Many	many	JJ
cord-262445-54ng7m92	422	2	evidences	evidence	NNS
cord-262445-54ng7m92	422	3	indicate	indicate	VBP
cord-262445-54ng7m92	422	4	that	that	IN
cord-262445-54ng7m92	422	5	PIN1	PIN1	NNP
cord-262445-54ng7m92	422	6	controls	control	VBZ
cord-262445-54ng7m92	422	7	signaling	signal	VBG
cord-262445-54ng7m92	422	8	pathways	pathway	NNS
cord-262445-54ng7m92	422	9	involved	involve	VBN
cord-262445-54ng7m92	422	10	in	in	IN
cord-262445-54ng7m92	422	11	skeletal	skeletal	JJ
cord-262445-54ng7m92	422	12	muscle	muscle	NN
cord-262445-54ng7m92	422	13	wasting	wasting	NN
cord-262445-54ng7m92	422	14	.	.	.
cord-262445-54ng7m92	423	1	Our	-PRON-	PRP$
cord-262445-54ng7m92	423	2	results	result	NNS
cord-262445-54ng7m92	423	3	indicate	indicate	VBP
cord-262445-54ng7m92	423	4	that	that	IN
cord-262445-54ng7m92	423	5	skeletal	skeletal	JJ
cord-262445-54ng7m92	423	6	muscle	muscle	NN
cord-262445-54ng7m92	423	7	of	of	IN
cord-262445-54ng7m92	423	8	Pin1	Pin1	NNP
cord-262445-54ng7m92	423	9	KO	KO	NNP
cord-262445-54ng7m92	423	10	mice	mouse	NNS
cord-262445-54ng7m92	423	11	is	be	VBZ
cord-262445-54ng7m92	423	12	protected	protect	VBN
cord-262445-54ng7m92	423	13	against	against	IN
cord-262445-54ng7m92	423	14	muscle	muscle	NN
cord-262445-54ng7m92	423	15	loss	loss	NN
cord-262445-54ng7m92	423	16	and	and	CC
cord-262445-54ng7m92	423	17	weakness	weakness	NN
cord-262445-54ng7m92	423	18	during	during	IN
cord-262445-54ng7m92	423	19	aging	age	VBG
cord-262445-54ng7m92	423	20	.	.	.
cord-262445-54ng7m92	424	1	At	at	IN
cord-262445-54ng7m92	424	2	the	the	DT
cord-262445-54ng7m92	424	3	molecular	molecular	JJ
cord-262445-54ng7m92	424	4	level	level	NN
cord-262445-54ng7m92	424	5	,	,	,
cord-262445-54ng7m92	424	6	we	-PRON-	PRP
cord-262445-54ng7m92	424	7	found	find	VBD
cord-262445-54ng7m92	424	8	1	1	CD
cord-262445-54ng7m92	424	9	)	)	-RRB-
cord-262445-54ng7m92	424	10	an	an	DT
cord-262445-54ng7m92	424	11	increased	increase	VBN
cord-262445-54ng7m92	424	12	expression	expression	NN
cord-262445-54ng7m92	424	13	of	of	IN
cord-262445-54ng7m92	424	14	Peroxisome	Peroxisome	NNP
cord-262445-54ng7m92	424	15	proliferator	proliferator	NN
cord-262445-54ng7m92	424	16	-	-	HYPH
cord-262445-54ng7m92	424	17	activated	activate	VBN
cord-262445-54ng7m92	424	18	receptor	receptor	NN
cord-262445-54ng7m92	424	19	gamma	gamma	NN
cord-262445-54ng7m92	424	20	coactivator	coactivator	NNP
cord-262445-54ng7m92	424	21	1-alpha	1-alpha	CD
cord-262445-54ng7m92	424	22	(	(	-LRB-
cord-262445-54ng7m92	424	23	PGC1α	PGC1α	NNP
cord-262445-54ng7m92	424	24	)	)	-RRB-
cord-262445-54ng7m92	424	25	,	,	,
cord-262445-54ng7m92	424	26	a	a	DT
cord-262445-54ng7m92	424	27	transcription	transcription	NN
cord-262445-54ng7m92	424	28	factor	factor	NN
cord-262445-54ng7m92	424	29	that	that	WDT
cord-262445-54ng7m92	424	30	promotes	promote	VBZ
cord-262445-54ng7m92	424	31	mitochondrial	mitochondrial	JJ
cord-262445-54ng7m92	424	32	biogenesis	biogenesis	NN
cord-262445-54ng7m92	424	33	,	,	,
cord-262445-54ng7m92	424	34	in	in	IN
cord-262445-54ng7m92	424	35	skeletal	skeletal	JJ
cord-262445-54ng7m92	424	36	muscle	muscle	NN
cord-262445-54ng7m92	424	37	of	of	IN
cord-262445-54ng7m92	424	38	Pin1	Pin1	NNP
cord-262445-54ng7m92	424	39	KO	KO	NNP
cord-262445-54ng7m92	424	40	mice	mouse	NNS
cord-262445-54ng7m92	424	41	.	.	.
cord-262445-54ng7m92	425	1	Coherently	coherently	RB
cord-262445-54ng7m92	425	2	with	with	IN
cord-262445-54ng7m92	425	3	their	-PRON-	PRP$
cord-262445-54ng7m92	425	4	resistance	resistance	NN
cord-262445-54ng7m92	425	5	to	to	IN
cord-262445-54ng7m92	425	6	muscle	muscle	NN
cord-262445-54ng7m92	425	7	loss	loss	NN
cord-262445-54ng7m92	425	8	,	,	,
cord-262445-54ng7m92	425	9	we	-PRON-	PRP
cord-262445-54ng7m92	425	10	also	also	RB
cord-262445-54ng7m92	425	11	found	find	VBD
cord-262445-54ng7m92	425	12	2	2	CD
cord-262445-54ng7m92	425	13	)	)	-RRB-
cord-262445-54ng7m92	425	14	an	an	DT
cord-262445-54ng7m92	425	15	increase	increase	NN
cord-262445-54ng7m92	425	16	in	in	IN
cord-262445-54ng7m92	425	17	the	the	DT
cord-262445-54ng7m92	425	18	expression	expression	NN
cord-262445-54ng7m92	425	19	of	of	IN
cord-262445-54ng7m92	425	20	the	the	DT
cord-262445-54ng7m92	425	21	protein	protein	NN
cord-262445-54ng7m92	425	22	synthetic	synthetic	NN
cord-262445-54ng7m92	425	23	signaling	signal	VBG
cord-262445-54ng7m92	425	24	proteins	protein	NNS
cord-262445-54ng7m92	425	25	p70	p70	CD
cord-262445-54ng7m92	425	26	ribosomal	ribosomal	JJ
cord-262445-54ng7m92	425	27	S6	S6	NNP
cord-262445-54ng7m92	425	28	kinase	kinase	NN
cord-262445-54ng7m92	425	29	(	(	-LRB-
cord-262445-54ng7m92	425	30	S6	S6	NNP
cord-262445-54ng7m92	425	31	K	K	NNP
cord-262445-54ng7m92	425	32	)	)	-RRB-
cord-262445-54ng7m92	425	33	and	and	CC
cord-262445-54ng7m92	425	34	of	of	IN
cord-262445-54ng7m92	425	35	its	-PRON-	PRP$
cord-262445-54ng7m92	425	36	phosphorylated	phosphorylated	JJ
cord-262445-54ng7m92	425	37	form	form	NN
cord-262445-54ng7m92	425	38	in	in	IN
cord-262445-54ng7m92	425	39	aged	aged	JJ
cord-262445-54ng7m92	425	40	skeletal	skeletal	JJ
cord-262445-54ng7m92	425	41	muscle	muscle	NN
cord-262445-54ng7m92	425	42	of	of	IN
cord-262445-54ng7m92	425	43	Pin1	Pin1	NNP
cord-262445-54ng7m92	425	44	KO	KO	NNP
cord-262445-54ng7m92	425	45	mice	mouse	NNS
cord-262445-54ng7m92	425	46	compared	compare	VBN
cord-262445-54ng7m92	425	47	to	to	IN
cord-262445-54ng7m92	425	48	the	the	DT
cord-262445-54ng7m92	425	49	wild	wild	JJ
cord-262445-54ng7m92	425	50	type	type	NN
cord-262445-54ng7m92	425	51	controls	control	NNS
cord-262445-54ng7m92	425	52	,	,	,
cord-262445-54ng7m92	425	53	suggesting	suggest	VBG
cord-262445-54ng7m92	425	54	that	that	IN
cord-262445-54ng7m92	425	55	in	in	IN
cord-262445-54ng7m92	425	56	these	these	DT
cord-262445-54ng7m92	425	57	mice	mice	NN
cord-262445-54ng7m92	425	58	protein	protein	NN
cord-262445-54ng7m92	425	59	synthesis	synthesis	NN
cord-262445-54ng7m92	425	60	is	be	VBZ
cord-262445-54ng7m92	425	61	maintained	maintain	VBN
cord-262445-54ng7m92	425	62	efficient	efficient	JJ
cord-262445-54ng7m92	425	63	.	.	.
cord-262445-54ng7m92	426	1	We	-PRON-	PRP
cord-262445-54ng7m92	426	2	also	also	RB
cord-262445-54ng7m92	426	3	found	find	VBD
cord-262445-54ng7m92	426	4	3	3	CD
cord-262445-54ng7m92	426	5	)	)	-RRB-
cord-262445-54ng7m92	426	6	a	a	DT
cord-262445-54ng7m92	426	7	significant	significant	JJ
cord-262445-54ng7m92	426	8	decrease	decrease	NN
cord-262445-54ng7m92	426	9	of	of	IN
cord-262445-54ng7m92	426	10	Myostatin	Myostatin	NNP
cord-262445-54ng7m92	426	11	levels	level	NNS
cord-262445-54ng7m92	426	12	in	in	IN
cord-262445-54ng7m92	426	13	skeletal	skeletal	JJ
cord-262445-54ng7m92	426	14	muscle	muscle	NN
cord-262445-54ng7m92	426	15	of	of	IN
cord-262445-54ng7m92	426	16	aged	aged	JJ
cord-262445-54ng7m92	426	17	Pin1	Pin1	NNP
cord-262445-54ng7m92	426	18	KO	KO	NNP
cord-262445-54ng7m92	426	19	mice	mouse	NNS
cord-262445-54ng7m92	426	20	.	.	.
cord-262445-54ng7m92	427	1	It	-PRON-	PRP
cord-262445-54ng7m92	427	2	is	be	VBZ
cord-262445-54ng7m92	427	3	well	well	RB
cord-262445-54ng7m92	427	4	known	know	VBN
cord-262445-54ng7m92	427	5	that	that	IN
cord-262445-54ng7m92	427	6	Myostatin	Myostatin	NNP
cord-262445-54ng7m92	427	7	is	be	VBZ
cord-262445-54ng7m92	427	8	up	up	RB
cord-262445-54ng7m92	427	9	regulated	regulated	JJ
cord-262445-54ng7m92	427	10	sarcopenia	sarcopenia	NN
cord-262445-54ng7m92	427	11	;	;	:
cord-262445-54ng7m92	427	12	it	-PRON-	PRP
cord-262445-54ng7m92	427	13	activates	activate	VBZ
cord-262445-54ng7m92	427	14	SMAD2/3	SMAD2/3	NNP
cord-262445-54ng7m92	427	15	signaling	signal	VBG
cord-262445-54ng7m92	427	16	and	and	CC
cord-262445-54ng7m92	427	17	contributes	contribute	VBZ
cord-262445-54ng7m92	427	18	to	to	IN
cord-262445-54ng7m92	427	19	protein	protein	NN
cord-262445-54ng7m92	427	20	degradation	degradation	NN
cord-262445-54ng7m92	427	21	and	and	CC
cord-262445-54ng7m92	427	22	muscle	muscle	NN
cord-262445-54ng7m92	427	23	atrophy	atrophy	NN
cord-262445-54ng7m92	427	24	.	.	.
cord-262445-54ng7m92	428	1	The	the	DT
cord-262445-54ng7m92	428	2	transcriptional	transcriptional	JJ
cord-262445-54ng7m92	428	3	effects	effect	NNS
cord-262445-54ng7m92	428	4	of	of	IN
cord-262445-54ng7m92	428	5	Pin1	Pin1	NNP
cord-262445-54ng7m92	428	6	depletion	depletion	NN
cord-262445-54ng7m92	428	7	on	on	IN
cord-262445-54ng7m92	428	8	PGC1α	PGC1α	NNP
cord-262445-54ng7m92	428	9	and	and	CC
cord-262445-54ng7m92	428	10	S6	S6	NNP
cord-262445-54ng7m92	428	11	K	K	NNP
cord-262445-54ng7m92	428	12	genes	gene	NNS
cord-262445-54ng7m92	428	13	must	must	MD
cord-262445-54ng7m92	428	14	be	be	VB
cord-262445-54ng7m92	428	15	mediated	mediate	VBN
cord-262445-54ng7m92	428	16	by	by	IN
cord-262445-54ng7m92	428	17	a	a	DT
cord-262445-54ng7m92	428	18	transcription	transcription	NN
cord-262445-54ng7m92	428	19	factor	factor	NN
cord-262445-54ng7m92	428	20	.	.	.
cord-262445-54ng7m92	429	1	A	a	DT
cord-262445-54ng7m92	429	2	putative	putative	JJ
cord-262445-54ng7m92	429	3	candidate	candidate	NN
cord-262445-54ng7m92	429	4	to	to	TO
cord-262445-54ng7m92	429	5	mediate	mediate	VB
cord-262445-54ng7m92	429	6	these	these	DT
cord-262445-54ng7m92	429	7	effects	effect	NNS
cord-262445-54ng7m92	429	8	is	be	VBZ
cord-262445-54ng7m92	429	9	represented	represent	VBN
cord-262445-54ng7m92	429	10	by	by	IN
cord-262445-54ng7m92	429	11	the	the	DT
cord-262445-54ng7m92	429	12	transcription	transcription	NN
cord-262445-54ng7m92	429	13	factor	factor	NN
cord-262445-54ng7m92	429	14	Myocyte	Myocyte	NNP
cord-262445-54ng7m92	429	15	Enhancer	Enhancer	NNP
cord-262445-54ng7m92	429	16	Factor	Factor	NNP
cord-262445-54ng7m92	429	17	2C	2c	NN
cord-262445-54ng7m92	429	18	(	(	-LRB-
cord-262445-54ng7m92	429	19	MEF2C	MEF2C	NNP
cord-262445-54ng7m92	429	20	)	)	-RRB-
cord-262445-54ng7m92	429	21	,	,	,
cord-262445-54ng7m92	429	22	a	a	DT
cord-262445-54ng7m92	429	23	known	know	VBN
cord-262445-54ng7m92	429	24	PIN1	PIN1	NNP
cord-262445-54ng7m92	429	25	target	target	NN
cord-262445-54ng7m92	429	26	.	.	.
cord-262445-54ng7m92	430	1	In	in	IN
cord-262445-54ng7m92	430	2	skeletal	skeletal	JJ
cord-262445-54ng7m92	430	3	muscle	muscle	NN
cord-262445-54ng7m92	430	4	cells	cell	NNS
cord-262445-54ng7m92	430	5	a	a	DT
cord-262445-54ng7m92	430	6	specific	specific	JJ
cord-262445-54ng7m92	430	7	splice	splice	NN
cord-262445-54ng7m92	430	8	variant	variant	NN
cord-262445-54ng7m92	430	9	of	of	IN
cord-262445-54ng7m92	430	10	MEF2C	mef2c	NN
cord-262445-54ng7m92	430	11	,	,	,
cord-262445-54ng7m92	430	12	MEF2C	MEF2C	NNP
cord-262445-54ng7m92	430	13	α1	α1	NNP
cord-262445-54ng7m92	430	14	,	,	,
cord-262445-54ng7m92	430	15	activates	activate	VBZ
cord-262445-54ng7m92	430	16	the	the	DT
cord-262445-54ng7m92	430	17	increase	increase	NN
cord-262445-54ng7m92	430	18	of	of	IN
cord-262445-54ng7m92	430	19	skeletal	skeletal	JJ
cord-262445-54ng7m92	430	20	muscle	muscle	NN
cord-262445-54ng7m92	430	21	mass	mass	NN
cord-262445-54ng7m92	430	22	by	by	IN
cord-262445-54ng7m92	430	23	activating	activate	VBG
cord-262445-54ng7m92	430	24	the	the	DT
cord-262445-54ng7m92	430	25	expression	expression	NN
cord-262445-54ng7m92	430	26	of	of	IN
cord-262445-54ng7m92	430	27	IGF1	IGF1	NNP
cord-262445-54ng7m92	430	28	and	and	CC
cord-262445-54ng7m92	430	29	S6K.	S6K.	NNPS
cord-262445-54ng7m92	430	30	These	these	DT
cord-262445-54ng7m92	430	31	activities	activity	NNS
cord-262445-54ng7m92	430	32	are	be	VBP
cord-262445-54ng7m92	430	33	repressed	repress	VBN
cord-262445-54ng7m92	430	34	by	by	IN
cord-262445-54ng7m92	430	35	its	-PRON-	PRP$
cord-262445-54ng7m92	430	36	phosphorylation	phosphorylation	NN
cord-262445-54ng7m92	430	37	,	,	,
cord-262445-54ng7m92	430	38	that	that	WDT
cord-262445-54ng7m92	430	39	renders	render	VBZ
cord-262445-54ng7m92	430	40	it	-PRON-	PRP
cord-262445-54ng7m92	430	41	a	a	DT
cord-262445-54ng7m92	430	42	target	target	NN
cord-262445-54ng7m92	430	43	for	for	IN
cord-262445-54ng7m92	430	44	the	the	DT
cord-262445-54ng7m92	430	45	inhibitory	inhibitory	JJ
cord-262445-54ng7m92	430	46	effect	effect	NN
cord-262445-54ng7m92	430	47	of	of	IN
cord-262445-54ng7m92	430	48	PIN1	PIN1	NNP
cord-262445-54ng7m92	430	49	on	on	IN
cord-262445-54ng7m92	430	50	its	-PRON-	PRP$
cord-262445-54ng7m92	430	51	protein	protein	NN
cord-262445-54ng7m92	430	52	stability	stability	NN
cord-262445-54ng7m92	430	53	and	and	CC
cord-262445-54ng7m92	430	54	activity	activity	NN
cord-262445-54ng7m92	430	55	.	.	.
cord-262445-54ng7m92	431	1	Coherently	coherently	RB
cord-262445-54ng7m92	431	2	with	with	IN
cord-262445-54ng7m92	431	3	these	these	DT
cord-262445-54ng7m92	431	4	premises	premise	NNS
cord-262445-54ng7m92	431	5	,	,	,
cord-262445-54ng7m92	431	6	we	-PRON-	PRP
cord-262445-54ng7m92	431	7	found	find	VBD
cord-262445-54ng7m92	431	8	4	4	CD
cord-262445-54ng7m92	431	9	)	)	-RRB-
cord-262445-54ng7m92	431	10	a	a	DT
cord-262445-54ng7m92	431	11	decrease	decrease	NN
cord-262445-54ng7m92	431	12	of	of	IN
cord-262445-54ng7m92	431	13	MEF2C	mef2c	NN
cord-262445-54ng7m92	431	14	protein	protein	NN
cord-262445-54ng7m92	431	15	phosphorylation	phosphorylation	NN
cord-262445-54ng7m92	431	16	levels	level	NNS
cord-262445-54ng7m92	431	17	in	in	IN
cord-262445-54ng7m92	431	18	aged	aged	JJ
cord-262445-54ng7m92	431	19	KO	KO	NNP
cord-262445-54ng7m92	431	20	mice	mouse	NNS
cord-262445-54ng7m92	431	21	compared	compare	VBN
cord-262445-54ng7m92	431	22	to	to	IN
cord-262445-54ng7m92	431	23	the	the	DT
cord-262445-54ng7m92	431	24	control	control	NN
cord-262445-54ng7m92	431	25	animals	animal	NNS
cord-262445-54ng7m92	431	26	.	.	.
cord-262445-54ng7m92	432	1	This	this	DT
cord-262445-54ng7m92	432	2	might	may	MD
cord-262445-54ng7m92	432	3	at	at	IN
cord-262445-54ng7m92	432	4	least	least	RBS
cord-262445-54ng7m92	432	5	partially	partially	RB
cord-262445-54ng7m92	432	6	contribute	contribute	VB
cord-262445-54ng7m92	432	7	to	to	IN
cord-262445-54ng7m92	432	8	the	the	DT
cord-262445-54ng7m92	432	9	increased	increase	VBN
cord-262445-54ng7m92	432	10	expression	expression	NN
cord-262445-54ng7m92	432	11	of	of	IN
cord-262445-54ng7m92	432	12	PGC1α	PGC1α	NNP
cord-262445-54ng7m92	432	13	and	and	CC
cord-262445-54ng7m92	432	14	of	of	IN
cord-262445-54ng7m92	433	1	S6K.	S6K.	NNP
cord-262445-54ng7m92	433	2	Our	-PRON-	PRP$
cord-262445-54ng7m92	433	3	results	result	NNS
cord-262445-54ng7m92	433	4	indicate	indicate	VBP
cord-262445-54ng7m92	433	5	that	that	IN
cord-262445-54ng7m92	433	6	PIN1	PIN1	NNP
cord-262445-54ng7m92	433	7	could	could	MD
cord-262445-54ng7m92	433	8	represent	represent	VB
cord-262445-54ng7m92	433	9	a	a	DT
cord-262445-54ng7m92	433	10	valuable	valuable	JJ
cord-262445-54ng7m92	433	11	pharmacological	pharmacological	JJ
cord-262445-54ng7m92	433	12	target	target	NN
cord-262445-54ng7m92	433	13	to	to	TO
cord-262445-54ng7m92	433	14	counteract	counteract	VB
cord-262445-54ng7m92	433	15	age	age	NN
cord-262445-54ng7m92	433	16	-	-	HYPH
cord-262445-54ng7m92	433	17	related	relate	VBN
cord-262445-54ng7m92	433	18	muscle	muscle	NN
cord-262445-54ng7m92	433	19	loss	loss	NN
cord-262445-54ng7m92	433	20	,	,	,
cord-262445-54ng7m92	433	21	simultaneously	simultaneously	RB
cord-262445-54ng7m92	433	22	modulating	modulate	VBG
cord-262445-54ng7m92	433	23	multiple	multiple	JJ
cord-262445-54ng7m92	433	24	targets	target	NNS
cord-262445-54ng7m92	433	25	in	in	IN
cord-262445-54ng7m92	433	26	a	a	DT
cord-262445-54ng7m92	433	27	concerted	concerted	JJ
cord-262445-54ng7m92	433	28	way	way	NN
cord-262445-54ng7m92	433	29	.	.	.
cord-262445-54ng7m92	434	1	Skeletal	skeletal	JJ
cord-262445-54ng7m92	434	2	muscle	muscle	NN
cord-262445-54ng7m92	434	3	(	(	-LRB-
cord-262445-54ng7m92	434	4	SkM	skm	NN
cord-262445-54ng7m92	434	5	)	)	-RRB-
cord-262445-54ng7m92	434	6	atrophy	atrophy	NN
cord-262445-54ng7m92	434	7	is	be	VBZ
cord-262445-54ng7m92	434	8	determined	determine	VBN
cord-262445-54ng7m92	434	9	by	by	IN
cord-262445-54ng7m92	434	10	several	several	JJ
cord-262445-54ng7m92	434	11	physiological	physiological	JJ
cord-262445-54ng7m92	434	12	and	and	CC
cord-262445-54ng7m92	434	13	pathological	pathological	JJ
cord-262445-54ng7m92	434	14	conditions	condition	NNS
cord-262445-54ng7m92	434	15	,	,	,
cord-262445-54ng7m92	434	16	such	such	JJ
cord-262445-54ng7m92	434	17	as	as	IN
cord-262445-54ng7m92	434	18	cancer	cancer	NN
cord-262445-54ng7m92	434	19	and	and	CC
cord-262445-54ng7m92	434	20	neuromuscular	neuromuscular	JJ
cord-262445-54ng7m92	434	21	disorders	disorder	NNS
cord-262445-54ng7m92	434	22	.	.	.
cord-262445-54ng7m92	435	1	Biomolecular	biomolecular	JJ
cord-262445-54ng7m92	435	2	characteristics	characteristic	NNS
cord-262445-54ng7m92	435	3	of	of	IN
cord-262445-54ng7m92	435	4	most	most	JJS
cord-262445-54ng7m92	435	5	types	type	NNS
cord-262445-54ng7m92	435	6	of	of	IN
cord-262445-54ng7m92	435	7	SkM	skm	NN
cord-262445-54ng7m92	435	8	atrophy	atrophy	NN
cord-262445-54ng7m92	435	9	are	be	VBP
cord-262445-54ng7m92	435	10	the	the	DT
cord-262445-54ng7m92	435	11	suppression	suppression	NN
cord-262445-54ng7m92	435	12	of	of	IN
cord-262445-54ng7m92	435	13	protein	protein	NN
cord-262445-54ng7m92	435	14	synthesis	synthesis	NN
cord-262445-54ng7m92	435	15	and	and	CC
cord-262445-54ng7m92	435	16	the	the	DT
cord-262445-54ng7m92	435	17	increase	increase	NN
cord-262445-54ng7m92	435	18	in	in	IN
cord-262445-54ng7m92	435	19	protein	protein	NN
cord-262445-54ng7m92	435	20	degradation	degradation	NN
cord-262445-54ng7m92	435	21	.	.	.
cord-262445-54ng7m92	436	1	Although	although	IN
cord-262445-54ng7m92	436	2	the	the	DT
cord-262445-54ng7m92	436	3	signalling	signal	VBG
cord-262445-54ng7m92	436	4	pathways	pathway	NNS
cord-262445-54ng7m92	436	5	involved	involve	VBN
cord-262445-54ng7m92	436	6	in	in	IN
cord-262445-54ng7m92	436	7	the	the	DT
cord-262445-54ng7m92	436	8	control	control	NN
cord-262445-54ng7m92	436	9	of	of	IN
cord-262445-54ng7m92	436	10	SkM	skm	NN
cord-262445-54ng7m92	436	11	waste	waste	NN
cord-262445-54ng7m92	436	12	are	be	VBP
cord-262445-54ng7m92	436	13	multiple	multiple	JJ
cord-262445-54ng7m92	436	14	,	,	,
cord-262445-54ng7m92	436	15	the	the	DT
cord-262445-54ng7m92	436	16	regulatory	regulatory	JJ
cord-262445-54ng7m92	436	17	role	role	NN
cord-262445-54ng7m92	436	18	of	of	IN
cord-262445-54ng7m92	436	19	lipids	lipid	NNS
cord-262445-54ng7m92	436	20	is	be	VBZ
cord-262445-54ng7m92	436	21	only	only	RB
cord-262445-54ng7m92	436	22	in	in	IN
cord-262445-54ng7m92	436	23	part	part	NN
cord-262445-54ng7m92	436	24	known	know	VBN
cord-262445-54ng7m92	436	25	.	.	.
cord-262445-54ng7m92	437	1	Sphingolipids	Sphingolipids	NNP
cord-262445-54ng7m92	437	2	(	(	-LRB-
cord-262445-54ng7m92	437	3	SLs	SLs	NNP
cord-262445-54ng7m92	437	4	)	)	-RRB-
cord-262445-54ng7m92	437	5	represent	represent	VBP
cord-262445-54ng7m92	437	6	a	a	DT
cord-262445-54ng7m92	437	7	class	class	NN
cord-262445-54ng7m92	437	8	of	of	IN
cord-262445-54ng7m92	437	9	bioactive	bioactive	JJ
cord-262445-54ng7m92	437	10	molecules	molecule	NNS
cord-262445-54ng7m92	437	11	capable	capable	JJ
cord-262445-54ng7m92	437	12	of	of	IN
cord-262445-54ng7m92	437	13	modulating	modulate	VBG
cord-262445-54ng7m92	437	14	the	the	DT
cord-262445-54ng7m92	437	15	destiny	destiny	NN
cord-262445-54ng7m92	437	16	of	of	IN
cord-262445-54ng7m92	437	17	many	many	JJ
cord-262445-54ng7m92	437	18	cell	cell	NN
cord-262445-54ng7m92	437	19	types	type	NNS
cord-262445-54ng7m92	437	20	,	,	,
cord-262445-54ng7m92	437	21	including	include	VBG
cord-262445-54ng7m92	437	22	SkM	skm	NN
cord-262445-54ng7m92	437	23	cells	cell	NNS
cord-262445-54ng7m92	437	24	.	.	.
cord-262445-54ng7m92	438	1	Here	here	RB
cord-262445-54ng7m92	438	2	,	,	,
cord-262445-54ng7m92	438	3	we	-PRON-	PRP
cord-262445-54ng7m92	438	4	investigated	investigate	VBD
cord-262445-54ng7m92	438	5	the	the	DT
cord-262445-54ng7m92	438	6	role	role	NN
cord-262445-54ng7m92	438	7	of	of	IN
cord-262445-54ng7m92	438	8	ceramide	ceramide	NN
cord-262445-54ng7m92	438	9	kinase	kinase	NN
cord-262445-54ng7m92	438	10	(	(	-LRB-
cord-262445-54ng7m92	438	11	CerK	CerK	NNP
cord-262445-54ng7m92	438	12	)	)	-RRB-
cord-262445-54ng7m92	438	13	,	,	,
cord-262445-54ng7m92	438	14	the	the	DT
cord-262445-54ng7m92	438	15	enzyme	enzyme	NN
cord-262445-54ng7m92	438	16	involved	involve	VBN
cord-262445-54ng7m92	438	17	in	in	IN
cord-262445-54ng7m92	438	18	the	the	DT
cord-262445-54ng7m92	438	19	phosphorylation	phosphorylation	NN
cord-262445-54ng7m92	438	20	of	of	IN
cord-262445-54ng7m92	438	21	Ceramide	ceramide	NN
cord-262445-54ng7m92	438	22	(	(	-LRB-
cord-262445-54ng7m92	438	23	Cer	Cer	NNP
cord-262445-54ng7m92	438	24	)	)	-RRB-
cord-262445-54ng7m92	438	25	to	to	IN
cord-262445-54ng7m92	438	26	Ceramide	ceramide	NN
cord-262445-54ng7m92	438	27	1-phosphate	1-phosphate	CD
cord-262445-54ng7m92	438	28	(	(	-LRB-
cord-262445-54ng7m92	438	29	C1P	c1p	CD
cord-262445-54ng7m92	438	30	)	)	-RRB-
cord-262445-54ng7m92	438	31	.	.	.
cord-262445-54ng7m92	439	1	We	-PRON-	PRP
cord-262445-54ng7m92	439	2	found	find	VBD
cord-262445-54ng7m92	439	3	that	that	IN
cord-262445-54ng7m92	439	4	the	the	DT
cord-262445-54ng7m92	439	5	expression	expression	NN
cord-262445-54ng7m92	439	6	of	of	IN
cord-262445-54ng7m92	439	7	CerK	CerK	NNP
cord-262445-54ng7m92	439	8	was	be	VBD
cord-262445-54ng7m92	439	9	comparable	comparable	JJ
cord-262445-54ng7m92	439	10	in	in	IN
cord-262445-54ng7m92	439	11	C2C12	c2c12	JJ
cord-262445-54ng7m92	439	12	myoblasts	myoblast	NNS
cord-262445-54ng7m92	439	13	and	and	CC
cord-262445-54ng7m92	439	14	in	in	IN
cord-262445-54ng7m92	439	15	terminally	terminally	RB
cord-262445-54ng7m92	439	16	differentiated	differentiate	VBN
cord-262445-54ng7m92	439	17	myotubes	myotube	NNS
cord-262445-54ng7m92	439	18	excluding	exclude	VBG
cord-262445-54ng7m92	439	19	that	that	IN
cord-262445-54ng7m92	439	20	CerK	CerK	NNP
cord-262445-54ng7m92	439	21	expression	expression	NN
cord-262445-54ng7m92	439	22	modulators	modulator	NNS
cord-262445-54ng7m92	439	23	may	may	MD
cord-262445-54ng7m92	439	24	be	be	VB
cord-262445-54ng7m92	439	25	required	require	VBN
cord-262445-54ng7m92	439	26	for	for	IN
cord-262445-54ng7m92	439	27	the	the	DT
cord-262445-54ng7m92	439	28	achievement	achievement	NN
cord-262445-54ng7m92	439	29	of	of	IN
cord-262445-54ng7m92	439	30	myogenic	myogenic	JJ
cord-262445-54ng7m92	439	31	differentiation	differentiation	NN
cord-262445-54ng7m92	439	32	.	.	.
cord-262445-54ng7m92	440	1	However	however	RB
cord-262445-54ng7m92	440	2	,	,	,
cord-262445-54ng7m92	440	3	CerK	CerK	NNP
cord-262445-54ng7m92	440	4	inhibition	inhibition	NN
cord-262445-54ng7m92	440	5	promotes	promote	VBZ
cord-262445-54ng7m92	440	6	myoblast	myoblast	JJ
cord-262445-54ng7m92	440	7	cell	cell	NN
cord-262445-54ng7m92	440	8	growth	growth	NN
cord-262445-54ng7m92	440	9	arrest	arrest	NN
cord-262445-54ng7m92	440	10	and	and	CC
cord-262445-54ng7m92	440	11	myotubes	myotubes	JJ
cord-262445-54ng7m92	440	12	reduction	reduction	NN
cord-262445-54ng7m92	440	13	in	in	IN
cord-262445-54ng7m92	440	14	size	size	NN
cord-262445-54ng7m92	440	15	suggesting	suggest	VBG
cord-262445-54ng7m92	440	16	a	a	DT
cord-262445-54ng7m92	440	17	role	role	NN
cord-262445-54ng7m92	440	18	of	of	IN
cord-262445-54ng7m92	440	19	Cer	Cer	NNP
cord-262445-54ng7m92	440	20	/	/	SYM
cord-262445-54ng7m92	440	21	CerK	CerK	NNP
cord-262445-54ng7m92	440	22	axis	axis	NN
cord-262445-54ng7m92	440	23	in	in	IN
cord-262445-54ng7m92	440	24	the	the	DT
cord-262445-54ng7m92	440	25	maintenance	maintenance	NN
cord-262445-54ng7m92	440	26	of	of	IN
cord-262445-54ng7m92	440	27	normal	normal	JJ
cord-262445-54ng7m92	440	28	mature	mature	JJ
cord-262445-54ng7m92	440	29	phenotype	phenotype	NN
cord-262445-54ng7m92	440	30	.	.	.
cord-262445-54ng7m92	441	1	Notably	notably	RB
cord-262445-54ng7m92	441	2	a	a	DT
cord-262445-54ng7m92	441	3	drastic	drastic	JJ
cord-262445-54ng7m92	441	4	decrease	decrease	NN
cord-262445-54ng7m92	441	5	of	of	IN
cord-262445-54ng7m92	441	6	CerK	CerK	NNP
cord-262445-54ng7m92	441	7	protein	protein	NN
cord-262445-54ng7m92	441	8	expression	expression	NN
cord-262445-54ng7m92	441	9	was	be	VBD
cord-262445-54ng7m92	441	10	observed	observe	VBN
cord-262445-54ng7m92	441	11	in	in	IN
cord-262445-54ng7m92	441	12	SkM	skm	NN
cord-262445-54ng7m92	441	13	tissues	tissue	NNS
cord-262445-54ng7m92	441	14	obtained	obtain	VBN
cord-262445-54ng7m92	441	15	from	from	IN
cord-262445-54ng7m92	441	16	animals	animal	NNS
cord-262445-54ng7m92	441	17	bearing	bear	VBG
cord-262445-54ng7m92	441	18	the	the	DT
cord-262445-54ng7m92	441	19	C26	C26	NNP
cord-262445-54ng7m92	441	20	tumor	tumor	NN
cord-262445-54ng7m92	441	21	,	,	,
cord-262445-54ng7m92	441	22	a	a	DT
cord-262445-54ng7m92	441	23	well	well	RB
cord-262445-54ng7m92	441	24	-	-	HYPH
cord-262445-54ng7m92	441	25	characterized	characterize	VBN
cord-262445-54ng7m92	441	26	experimental	experimental	JJ
cord-262445-54ng7m92	441	27	model	model	NN
cord-262445-54ng7m92	441	28	of	of	IN
cord-262445-54ng7m92	441	29	cancer	cancer	NN
cord-262445-54ng7m92	441	30	cachexia	cachexia	NN
cord-262445-54ng7m92	441	31	,	,	,
cord-262445-54ng7m92	441	32	and	and	CC
cord-262445-54ng7m92	441	33	in	in	IN
cord-262445-54ng7m92	441	34	C2C12	c2c12	JJ
cord-262445-54ng7m92	441	35	myotubes	myotube	NNS
cord-262445-54ng7m92	441	36	treated	treat	VBN
cord-262445-54ng7m92	441	37	with	with	IN
cord-262445-54ng7m92	441	38	the	the	DT
cord-262445-54ng7m92	441	39	glucocorticoid	glucocorticoid	NN
cord-262445-54ng7m92	441	40	Dexamethasone	Dexamethasone	NNP
cord-262445-54ng7m92	441	41	.	.	.
cord-262445-54ng7m92	442	1	These	these	DT
cord-262445-54ng7m92	442	2	findings	finding	NNS
cord-262445-54ng7m92	442	3	provide	provide	VBP
cord-262445-54ng7m92	442	4	the	the	DT
cord-262445-54ng7m92	442	5	evidence	evidence	NN
cord-262445-54ng7m92	442	6	that	that	IN
cord-262445-54ng7m92	442	7	Cer	Cer	NNP
cord-262445-54ng7m92	442	8	/	/	SYM
cord-262445-54ng7m92	442	9	CerK	CerK	NNP
cord-262445-54ng7m92	442	10	axis	axis	NN
cord-262445-54ng7m92	442	11	acts	act	VBZ
cord-262445-54ng7m92	442	12	as	as	IN
cord-262445-54ng7m92	442	13	a	a	DT
cord-262445-54ng7m92	442	14	molecular	molecular	JJ
cord-262445-54ng7m92	442	15	regulator	regulator	NN
cord-262445-54ng7m92	442	16	of	of	IN
cord-262445-54ng7m92	442	17	SkM	skm	NN
cord-262445-54ng7m92	442	18	atrophy	atrophy	NN
cord-262445-54ng7m92	442	19	,	,	,
cord-262445-54ng7m92	442	20	thereby	thereby	RB
cord-262445-54ng7m92	442	21	representing	represent	VBG
cord-262445-54ng7m92	442	22	a	a	DT
cord-262445-54ng7m92	442	23	new	new	JJ
cord-262445-54ng7m92	442	24	possible	possible	JJ
cord-262445-54ng7m92	442	25	target	target	NN
cord-262445-54ng7m92	442	26	for	for	IN
cord-262445-54ng7m92	442	27	therapy	therapy	NN
cord-262445-54ng7m92	442	28	in	in	IN
cord-262445-54ng7m92	442	29	pathophysiological	pathophysiological	JJ
cord-262445-54ng7m92	442	30	muscle	muscle	NN
cord-262445-54ng7m92	442	31	conditions	condition	NNS
cord-262445-54ng7m92	442	32	.	.	.
cord-262445-54ng7m92	443	1	Cachexia	cachexia	NN
cord-262445-54ng7m92	443	2	is	be	VBZ
cord-262445-54ng7m92	443	3	a	a	DT
cord-262445-54ng7m92	443	4	debilitating	debilitating	JJ
cord-262445-54ng7m92	443	5	syndrome	syndrome	NN
cord-262445-54ng7m92	443	6	affecting	affect	VBG
cord-262445-54ng7m92	443	7	the	the	DT
cord-262445-54ng7m92	443	8	majority	majority	NN
cord-262445-54ng7m92	443	9	of	of	IN
cord-262445-54ng7m92	443	10	patients	patient	NNS
cord-262445-54ng7m92	443	11	with	with	IN
cord-262445-54ng7m92	443	12	advanced	advanced	JJ
cord-262445-54ng7m92	443	13	cancer	cancer	NN
cord-262445-54ng7m92	443	14	,	,	,
cord-262445-54ng7m92	443	15	and	and	CC
cord-262445-54ng7m92	443	16	directly	directly	RB
cord-262445-54ng7m92	443	17	responsible	responsible	JJ
cord-262445-54ng7m92	443	18	for	for	IN
cord-262445-54ng7m92	443	19	about	about	RB
cord-262445-54ng7m92	443	20	20	20	CD
cord-262445-54ng7m92	443	21	%	%	NN
cord-262445-54ng7m92	443	22	of	of	IN
cord-262445-54ng7m92	443	23	all	all	DT
cord-262445-54ng7m92	443	24	cancer	cancer	NN
cord-262445-54ng7m92	443	25	-	-	HYPH
cord-262445-54ng7m92	443	26	associated	associate	VBN
cord-262445-54ng7m92	443	27	deaths	death	NNS
cord-262445-54ng7m92	443	28	.	.	.
cord-262445-54ng7m92	444	1	The	the	DT
cord-262445-54ng7m92	444	2	major	major	JJ
cord-262445-54ng7m92	444	3	clinical	clinical	JJ
cord-262445-54ng7m92	444	4	feature	feature	NN
cord-262445-54ng7m92	444	5	of	of	IN
cord-262445-54ng7m92	444	6	cachexia	cachexia	NN
cord-262445-54ng7m92	444	7	is	be	VBZ
cord-262445-54ng7m92	444	8	skeletal	skeletal	JJ
cord-262445-54ng7m92	444	9	muscle	muscle	NN
cord-262445-54ng7m92	444	10	atrophy	atrophy	NN
cord-262445-54ng7m92	444	11	that	that	WDT
cord-262445-54ng7m92	444	12	leads	lead	VBZ
cord-262445-54ng7m92	444	13	to	to	IN
cord-262445-54ng7m92	444	14	pronounced	pronounced	VB
cord-262445-54ng7m92	444	15	weight	weight	NN
cord-262445-54ng7m92	444	16	loss	loss	NN
cord-262445-54ng7m92	444	17	,	,	,
cord-262445-54ng7m92	444	18	drastically	drastically	RB
cord-262445-54ng7m92	444	19	dampens	dampen	VBZ
cord-262445-54ng7m92	444	20	patients	patient	NNS
cord-262445-54ng7m92	444	21	'	'	POS
cord-262445-54ng7m92	444	22	quality	quality	NN
cord-262445-54ng7m92	444	23	of	of	IN
cord-262445-54ng7m92	444	24	life	life	NN
cord-262445-54ng7m92	444	25	,	,	,
cord-262445-54ng7m92	444	26	reduces	reduce	VBZ
cord-262445-54ng7m92	444	27	the	the	DT
cord-262445-54ng7m92	444	28	response	response	NN
cord-262445-54ng7m92	444	29	and	and	CC
cord-262445-54ng7m92	444	30	tolerance	tolerance	NN
cord-262445-54ng7m92	444	31	to	to	IN
cord-262445-54ng7m92	444	32	chemotherapy	chemotherapy	NN
cord-262445-54ng7m92	444	33	,	,	,
cord-262445-54ng7m92	444	34	and	and	CC
cord-262445-54ng7m92	444	35	is	be	VBZ
cord-262445-54ng7m92	444	36	associated	associate	VBN
cord-262445-54ng7m92	444	37	with	with	IN
cord-262445-54ng7m92	444	38	poor	poor	JJ
cord-262445-54ng7m92	444	39	prognosis	prognosis	NN
cord-262445-54ng7m92	444	40	and	and	CC
cord-262445-54ng7m92	444	41	outcome	outcome	NN
cord-262445-54ng7m92	444	42	(	(	-LRB-
cord-262445-54ng7m92	444	43	1	1	CD
cord-262445-54ng7m92	444	44	)	)	-RRB-
cord-262445-54ng7m92	444	45	.	.	.
cord-262445-54ng7m92	445	1	The	the	DT
cord-262445-54ng7m92	445	2	identification	identification	NN
cord-262445-54ng7m92	445	3	of	of	IN
cord-262445-54ng7m92	445	4	reliable	reliable	JJ
cord-262445-54ng7m92	445	5	biomarkers	biomarker	NNS
cord-262445-54ng7m92	445	6	of	of	IN
cord-262445-54ng7m92	445	7	cachexia	cachexia	NN
cord-262445-54ng7m92	445	8	is	be	VBZ
cord-262445-54ng7m92	445	9	of	of	IN
cord-262445-54ng7m92	445	10	great	great	JJ
cord-262445-54ng7m92	445	11	importance	importance	NN
cord-262445-54ng7m92	445	12	to	to	TO
cord-262445-54ng7m92	445	13	identify	identify	VB
cord-262445-54ng7m92	445	14	patients	patient	NNS
cord-262445-54ng7m92	445	15	in	in	IN
cord-262445-54ng7m92	445	16	the	the	DT
cord-262445-54ng7m92	445	17	different	different	JJ
cord-262445-54ng7m92	445	18	phases	phase	NNS
cord-262445-54ng7m92	445	19	of	of	IN
cord-262445-54ng7m92	445	20	the	the	DT
cord-262445-54ng7m92	445	21	disease	disease	NN
cord-262445-54ng7m92	445	22	and	and	CC
cord-262445-54ng7m92	445	23	to	to	TO
cord-262445-54ng7m92	445	24	monitor	monitor	VB
cord-262445-54ng7m92	445	25	the	the	DT
cord-262445-54ng7m92	445	26	treatment	treatment	NN
cord-262445-54ng7m92	445	27	outcome	outcome	NN
cord-262445-54ng7m92	445	28	(	(	-LRB-
cord-262445-54ng7m92	445	29	2	2	CD
cord-262445-54ng7m92	445	30	)	)	-RRB-
cord-262445-54ng7m92	445	31	.	.	.
cord-262445-54ng7m92	446	1	RAGE	rage	NN
cord-262445-54ng7m92	447	1	(	(	-LRB-
cord-262445-54ng7m92	447	2	receptor	receptor	NN
cord-262445-54ng7m92	447	3	for	for	IN
cord-262445-54ng7m92	447	4	advanced	advanced	JJ
cord-262445-54ng7m92	447	5	glycation	glycation	NN
cord-262445-54ng7m92	447	6	end	end	NN
cord-262445-54ng7m92	447	7	-	-	HYPH
cord-262445-54ng7m92	447	8	products	product	NNS
cord-262445-54ng7m92	447	9	)	)	-RRB-
cord-262445-54ng7m92	447	10	is	be	VBZ
cord-262445-54ng7m92	447	11	a	a	DT
cord-262445-54ng7m92	447	12	multiligand	multiligand	NN
cord-262445-54ng7m92	447	13	receptor	receptor	NN
cord-262445-54ng7m92	447	14	of	of	IN
cord-262445-54ng7m92	447	15	the	the	DT
cord-262445-54ng7m92	447	16	immunoglobulin	immunoglobulin	NN
cord-262445-54ng7m92	447	17	superfamily	superfamily	NN
cord-262445-54ng7m92	447	18	physiologically	physiologically	RB
cord-262445-54ng7m92	447	19	involved	involve	VBN
cord-262445-54ng7m92	447	20	in	in	IN
cord-262445-54ng7m92	447	21	skeletal	skeletal	JJ
cord-262445-54ng7m92	447	22	muscle	muscle	NN
cord-262445-54ng7m92	447	23	development	development	NN
cord-262445-54ng7m92	447	24	and	and	CC
cord-262445-54ng7m92	447	25	homeostasis	homeostasis	NN
cord-262445-54ng7m92	447	26	(	(	-LRB-
cord-262445-54ng7m92	447	27	3	3	CD
cord-262445-54ng7m92	447	28	)	)	-RRB-
cord-262445-54ng7m92	447	29	.	.	.
cord-262445-54ng7m92	448	1	In	in	IN
cord-262445-54ng7m92	448	2	cancer	cancer	NN
cord-262445-54ng7m92	448	3	conditions	condition	NNS
cord-262445-54ng7m92	448	4	,	,	,
cord-262445-54ng7m92	448	5	the	the	DT
cord-262445-54ng7m92	448	6	increase	increase	NN
cord-262445-54ng7m92	448	7	of	of	IN
cord-262445-54ng7m92	448	8	RAGE	rage	NN
cord-262445-54ng7m92	448	9	ligands	ligand	NNS
cord-262445-54ng7m92	448	10	levels	level	NNS
cord-262445-54ng7m92	448	11	leads	lead	VBZ
cord-262445-54ng7m92	448	12	to	to	IN
cord-262445-54ng7m92	448	13	hyperstimulation	hyperstimulation	NN
cord-262445-54ng7m92	448	14	of	of	IN
cord-262445-54ng7m92	448	15	the	the	DT
cord-262445-54ng7m92	448	16	receptor	receptor	NN
cord-262445-54ng7m92	448	17	translating	translate	VBG
cord-262445-54ng7m92	448	18	into	into	IN
cord-262445-54ng7m92	448	19	systemic	systemic	JJ
cord-262445-54ng7m92	448	20	inflammation	inflammation	NN
cord-262445-54ng7m92	448	21	and	and	CC
cord-262445-54ng7m92	448	22	muscle	muscle	NN
cord-262445-54ng7m92	448	23	wasting	wasting	NN
cord-262445-54ng7m92	448	24	,	,	,
cord-262445-54ng7m92	448	25	and	and	CC
cord-262445-54ng7m92	448	26	reducing	reduce	VBG
cord-262445-54ng7m92	448	27	mouse	mouse	NN
cord-262445-54ng7m92	448	28	survival	survival	NN
cord-262445-54ng7m92	448	29	(	(	-LRB-
cord-262445-54ng7m92	448	30	4	4	CD
cord-262445-54ng7m92	448	31	)	)	-RRB-
cord-262445-54ng7m92	448	32	.	.	.
cord-262445-54ng7m92	449	1	We	-PRON-	PRP
cord-262445-54ng7m92	449	2	analysed	analyse	VBD
cord-262445-54ng7m92	449	3	RAGE	rage	NN
cord-262445-54ng7m92	449	4	expression	expression	NN
cord-262445-54ng7m92	449	5	in	in	IN
cord-262445-54ng7m92	449	6	muscle	muscle	NN
cord-262445-54ng7m92	449	7	tissue	tissue	NN
cord-262445-54ng7m92	449	8	of	of	IN
cord-262445-54ng7m92	449	9	different	different	JJ
cord-262445-54ng7m92	449	10	preclinical	preclinical	JJ
cord-262445-54ng7m92	449	11	mouse	mouse	NN
cord-262445-54ng7m92	449	12	models	model	NNS
cord-262445-54ng7m92	449	13	of	of	IN
cord-262445-54ng7m92	449	14	cancer	cancer	NN
cord-262445-54ng7m92	449	15	cachexia	cachexia	NN
cord-262445-54ng7m92	449	16	[	[	-LRB-
cord-262445-54ng7m92	449	17	Lewis	Lewis	NNP
cord-262445-54ng7m92	449	18	lung	lung	NN
cord-262445-54ng7m92	449	19	carcinoma	carcinoma	NN
cord-262445-54ng7m92	449	20	(	(	-LRB-
cord-262445-54ng7m92	449	21	LLC)-bearing	llc)-beare	VBG
cord-262445-54ng7m92	449	22	C57Bl/6	C57Bl/6	NNPS
cord-262445-54ng7m92	449	23	and	and	CC
cord-262445-54ng7m92	449	24	colon	colon	NN
cord-262445-54ng7m92	449	25	adenocarcinoma	adenocarcinoma	NN
cord-262445-54ng7m92	450	1	(	(	-LRB-
cord-262445-54ng7m92	450	2	C26-ADK)-bearing	c26-adk)-beare	VBG
cord-262445-54ng7m92	450	3	BALB	BALB	NNP
cord-262445-54ng7m92	450	4	/	/	SYM
cord-262445-54ng7m92	450	5	c	c	NN
cord-262445-54ng7m92	450	6	mice	mouse	NNS
cord-262445-54ng7m92	450	7	]	]	-RRB-
cord-262445-54ng7m92	450	8	in	in	IN
cord-262445-54ng7m92	450	9	the	the	DT
cord-262445-54ng7m92	450	10	absence	absence	NN
cord-262445-54ng7m92	450	11	or	or	CC
cord-262445-54ng7m92	450	12	presence	presence	NN
cord-262445-54ng7m92	450	13	of	of	IN
cord-262445-54ng7m92	450	14	voluntary	voluntary	JJ
cord-262445-54ng7m92	450	15	endurance	endurance	NN
cord-262445-54ng7m92	450	16	exercise	exercise	NN
cord-262445-54ng7m92	450	17	(	(	-LRB-
cord-262445-54ng7m92	450	18	wheel	wheel	NN
cord-262445-54ng7m92	450	19	)	)	-RRB-
cord-262445-54ng7m92	450	20	,	,	,
cord-262445-54ng7m92	450	21	which	which	WDT
cord-262445-54ng7m92	450	22	has	have	VBZ
cord-262445-54ng7m92	450	23	been	be	VBN
cord-262445-54ng7m92	450	24	reported	report	VBN
cord-262445-54ng7m92	450	25	to	to	TO
cord-262445-54ng7m92	450	26	partially	partially	RB
cord-262445-54ng7m92	450	27	antagonize	antagonize	VB
cord-262445-54ng7m92	450	28	muscle	muscle	NN
cord-262445-54ng7m92	450	29	wasting	waste	VBG
cord-262445-54ng7m92	450	30	in	in	IN
cord-262445-54ng7m92	450	31	mice	mouse	NNS
cord-262445-54ng7m92	450	32	(	(	-LRB-
cord-262445-54ng7m92	450	33	5	5	CD
cord-262445-54ng7m92	450	34	)	)	-RRB-
cord-262445-54ng7m92	450	35	,	,	,
cord-262445-54ng7m92	450	36	and	and	CC
cord-262445-54ng7m92	450	37	correlated	correlate	VBN
cord-262445-54ng7m92	450	38	RAGE	rage	NN
cord-262445-54ng7m92	450	39	expression	expression	NN
cord-262445-54ng7m92	450	40	with	with	IN
cord-262445-54ng7m92	450	41	myofiber	myofiber	NNP
cord-262445-54ng7m92	450	42	crosssectional	crosssectional	NNP
cord-262445-54ng7m92	450	43	area	area	NN
cord-262445-54ng7m92	450	44	(	(	-LRB-
cord-262445-54ng7m92	450	45	CSA	CSA	NNP
cord-262445-54ng7m92	450	46	)	)	-RRB-
cord-262445-54ng7m92	450	47	and	and	CC
cord-262445-54ng7m92	450	48	hallmarks	hallmark	NNS
cord-262445-54ng7m92	450	49	of	of	IN
cord-262445-54ng7m92	450	50	muscle	muscle	NN
cord-262445-54ng7m92	450	51	atrophy	atrophy	NN
cord-262445-54ng7m92	450	52	(	(	-LRB-
cord-262445-54ng7m92	450	53	body	body	NN
cord-262445-54ng7m92	450	54	and	and	CC
cord-262445-54ng7m92	450	55	muscle	muscle	NN
cord-262445-54ng7m92	450	56	weights	weight	NNS
cord-262445-54ng7m92	450	57	,	,	,
cord-262445-54ng7m92	450	58	protein	protein	NN
cord-262445-54ng7m92	450	59	degradation	degradation	NN
cord-262445-54ng7m92	450	60	extent	extent	NN
cord-262445-54ng7m92	450	61	,	,	,
cord-262445-54ng7m92	450	62	and	and	CC
cord-262445-54ng7m92	450	63	activation	activation	NN
cord-262445-54ng7m92	450	64	of	of	IN
cord-262445-54ng7m92	450	65	proteolytic	proteolytic	JJ
cord-262445-54ng7m92	450	66	systems	system	NNS
cord-262445-54ng7m92	450	67	)	)	-RRB-
cord-262445-54ng7m92	450	68	.	.	.
cord-262445-54ng7m92	451	1	We	-PRON-	PRP
cord-262445-54ng7m92	451	2	also	also	RB
cord-262445-54ng7m92	451	3	analysed	analyse	VBD
cord-262445-54ng7m92	451	4	RAGE	rage	NN
cord-262445-54ng7m92	451	5	expression	expression	NN
cord-262445-54ng7m92	451	6	in	in	IN
cord-262445-54ng7m92	451	7	muscle	muscle	NN
cord-262445-54ng7m92	451	8	biopsies	biopsy	NNS
cord-262445-54ng7m92	451	9	from	from	IN
cord-262445-54ng7m92	451	10	cancer	cancer	NN
cord-262445-54ng7m92	451	11	patients	patient	NNS
cord-262445-54ng7m92	451	12	.	.	.
cord-262445-54ng7m92	452	1	We	-PRON-	PRP
cord-262445-54ng7m92	452	2	found	find	VBD
cord-262445-54ng7m92	452	3	that	that	DT
cord-262445-54ng7m92	452	4	:	:	:
cord-262445-54ng7m92	452	5	i	i	LS
cord-262445-54ng7m92	452	6	)	)	-RRB-
cord-262445-54ng7m92	452	7	LLC	LLC	NNP
cord-262445-54ng7m92	452	8	-	-	HYPH
cord-262445-54ng7m92	452	9	and	and	CC
cord-262445-54ng7m92	452	10	C26-ADK	C26-ADK	NNS
cord-262445-54ng7m92	452	11	-	-	HYPH
cord-262445-54ng7m92	452	12	bearing	bear	VBG
cord-262445-54ng7m92	452	13	mice	mouse	NNS
cord-262445-54ng7m92	452	14	express	express	VBP
cord-262445-54ng7m92	452	15	RAGE	rage	NN
cord-262445-54ng7m92	452	16	in	in	IN
cord-262445-54ng7m92	452	17	myofibers	myofiber	NNS
cord-262445-54ng7m92	452	18	in	in	IN
cord-262445-54ng7m92	452	19	coincidence	coincidence	NN
cord-262445-54ng7m92	452	20	with	with	IN
cord-262445-54ng7m92	452	21	reduced	reduce	VBN
cord-262445-54ng7m92	452	22	body	body	NN
cord-262445-54ng7m92	452	23	and	and	CC
cord-262445-54ng7m92	452	24	muscle	muscle	NN
cord-262445-54ng7m92	452	25	weights	weight	NNS
cord-262445-54ng7m92	452	26	and	and	CC
cord-262445-54ng7m92	452	27	induction	induction	NN
cord-262445-54ng7m92	452	28	of	of	IN
cord-262445-54ng7m92	452	29	proteolysis	proteolysis	NN
cord-262445-54ng7m92	452	30	;	;	:
cord-262445-54ng7m92	452	31	ii	ii	LS
cord-262445-54ng7m92	452	32	)	)	-RRB-
cord-262445-54ng7m92	452	33	an	an	DT
cord-262445-54ng7m92	452	34	inverse	inverse	JJ
cord-262445-54ng7m92	452	35	relationship	relationship	NN
cord-262445-54ng7m92	452	36	exists	exist	VBZ
cord-262445-54ng7m92	452	37	between	between	IN
cord-262445-54ng7m92	452	38	RAGE	rage	NN
cord-262445-54ng7m92	452	39	expression	expression	NN
cord-262445-54ng7m92	452	40	in	in	IN
cord-262445-54ng7m92	452	41	muscles	muscle	NNS
cord-262445-54ng7m92	452	42	and	and	CC
cord-262445-54ng7m92	452	43	tumor	tumor	NN
cord-262445-54ng7m92	452	44	masses	masse	NNS
cord-262445-54ng7m92	452	45	and	and	CC
cord-262445-54ng7m92	452	46	the	the	DT
cord-262445-54ng7m92	452	47	beneficial	beneficial	JJ
cord-262445-54ng7m92	452	48	effects	effect	NNS
cord-262445-54ng7m92	452	49	of	of	IN
cord-262445-54ng7m92	452	50	endurance	endurance	NN
cord-262445-54ng7m92	452	51	exercise	exercise	NN
cord-262445-54ng7m92	452	52	in	in	IN
cord-262445-54ng7m92	452	53	LLC	LLC	NNP
cord-262445-54ng7m92	452	54	-	-	HYPH
cord-262445-54ng7m92	452	55	bearing	bear	VBG
cord-262445-54ng7m92	452	56	mice	mouse	NNS
cord-262445-54ng7m92	452	57	;	;	:
cord-262445-54ng7m92	452	58	iii	iii	LS
cord-262445-54ng7m92	452	59	)	)	-RRB-
cord-262445-54ng7m92	453	1	RAGE	rage	NN
cord-262445-54ng7m92	453	2	expression	expression	NN
cord-262445-54ng7m92	453	3	increases	increase	VBZ
cord-262445-54ng7m92	453	4	in	in	IN
cord-262445-54ng7m92	453	5	muscles	muscle	NNS
cord-262445-54ng7m92	453	6	during	during	IN
cord-262445-54ng7m92	453	7	cachexia	cachexia	NN
cord-262445-54ng7m92	453	8	progression	progression	NN
cord-262445-54ng7m92	453	9	;	;	:
cord-262445-54ng7m92	453	10	iv	iv	LS
cord-262445-54ng7m92	453	11	)	)	-RRB-
cord-262445-54ng7m92	453	12	RAGE	rage	NN
cord-262445-54ng7m92	453	13	is	be	VBZ
cord-262445-54ng7m92	453	14	not	not	RB
cord-262445-54ng7m92	453	15	expressed	express	VBN
cord-262445-54ng7m92	453	16	in	in	IN
cord-262445-54ng7m92	453	17	myofibers	myofiber	NNS
cord-262445-54ng7m92	453	18	of	of	IN
cord-262445-54ng7m92	453	19	athymic	athymic	JJ
cord-262445-54ng7m92	453	20	-	-	HYPH
cord-262445-54ng7m92	453	21	nude	nude	JJ
cord-262445-54ng7m92	453	22	mice	mouse	NNS
cord-262445-54ng7m92	453	23	injected	inject	VBN
cord-262445-54ng7m92	453	24	subcutaneously	subcutaneously	RB
cord-262445-54ng7m92	453	25	with	with	IN
cord-262445-54ng7m92	453	26	LLC	LLC	NNP
cord-262445-54ng7m92	453	27	or	or	CC
cord-262445-54ng7m92	453	28	melanoma	melanoma	NN
cord-262445-54ng7m92	453	29	A375	a375	CD
cord-262445-54ng7m92	453	30	cells	cell	NNS
cord-262445-54ng7m92	453	31	,	,	,
cord-262445-54ng7m92	453	32	which	which	WDT
cord-262445-54ng7m92	453	33	do	do	VBP
cord-262445-54ng7m92	453	34	not	not	RB
cord-262445-54ng7m92	453	35	develop	develop	VB
cord-262445-54ng7m92	453	36	cachexia	cachexia	NN
cord-262445-54ng7m92	453	37	;	;	:
cord-262445-54ng7m92	453	38	and	and	CC
cord-262445-54ng7m92	453	39	v	v	LS
cord-262445-54ng7m92	453	40	)	)	-RRB-
cord-262445-54ng7m92	453	41	muscles	muscle	NNS
cord-262445-54ng7m92	453	42	of	of	IN
cord-262445-54ng7m92	453	43	cachectic	cachectic	JJ
cord-262445-54ng7m92	453	44	patients	patient	NNS
cord-262445-54ng7m92	453	45	express	express	VBP
cord-262445-54ng7m92	453	46	higher	high	JJR
cord-262445-54ng7m92	453	47	amounts	amount	NNS
cord-262445-54ng7m92	453	48	of	of	IN
cord-262445-54ng7m92	453	49	RAGE	rage	NN
cord-262445-54ng7m92	453	50	than	than	IN
cord-262445-54ng7m92	453	51	non	non	JJ
cord-262445-54ng7m92	453	52	-	-	JJ
cord-262445-54ng7m92	453	53	cachectic	cachectic	JJ
cord-262445-54ng7m92	453	54	subjects	subject	NNS
cord-262445-54ng7m92	453	55	.	.	.
cord-262445-54ng7m92	454	1	Altogether	altogether	RB
cord-262445-54ng7m92	454	2	,	,	,
cord-262445-54ng7m92	454	3	our	-PRON-	PRP$
cord-262445-54ng7m92	454	4	results	result	NNS
cord-262445-54ng7m92	454	5	suggest	suggest	VBP
cord-262445-54ng7m92	454	6	that	that	IN
cord-262445-54ng7m92	454	7	RAGE	rage	NN
cord-262445-54ng7m92	454	8	might	may	MD
cord-262445-54ng7m92	454	9	represent	represent	VB
cord-262445-54ng7m92	454	10	a	a	DT
cord-262445-54ng7m92	454	11	biomarker	biomarker	NN
cord-262445-54ng7m92	454	12	to	to	TO
cord-262445-54ng7m92	454	13	monitor	monitor	VB
cord-262445-54ng7m92	454	14	the	the	DT
cord-262445-54ng7m92	454	15	cachectic	cachectic	JJ
cord-262445-54ng7m92	454	16	stage	stage	NN
cord-262445-54ng7m92	454	17	at	at	IN
cord-262445-54ng7m92	454	18	muscle	muscle	NN
cord-262445-54ng7m92	454	19	level	level	NN
cord-262445-54ng7m92	454	20	.	.	.
cord-262445-54ng7m92	455	1	Tissue	tissue	NN
cord-262445-54ng7m92	455	2	engineering	engineering	NN
cord-262445-54ng7m92	455	3	(	(	-LRB-
cord-262445-54ng7m92	455	4	TE	TE	NNP
cord-262445-54ng7m92	455	5	)	)	-RRB-
cord-262445-54ng7m92	455	6	and	and	CC
cord-262445-54ng7m92	455	7	regenerative	regenerative	JJ
cord-262445-54ng7m92	455	8	medicine	medicine	NN
cord-262445-54ng7m92	455	9	approaches	approach	NNS
cord-262445-54ng7m92	455	10	are	be	VBP
cord-262445-54ng7m92	455	11	designed	design	VBN
cord-262445-54ng7m92	455	12	to	to	TO
cord-262445-54ng7m92	455	13	increase	increase	VB
cord-262445-54ng7m92	455	14	skeletal	skeletal	JJ
cord-262445-54ng7m92	455	15	muscle	muscle	NN
cord-262445-54ng7m92	455	16	damage	damage	NN
cord-262445-54ng7m92	455	17	response	response	NN
cord-262445-54ng7m92	455	18	.	.	.
cord-262445-54ng7m92	456	1	Scientific	scientific	JJ
cord-262445-54ng7m92	456	2	advances	advance	NNS
cord-262445-54ng7m92	456	3	in	in	IN
cord-262445-54ng7m92	456	4	biomaterials	biomaterial	NNS
cord-262445-54ng7m92	456	5	and	and	CC
cord-262445-54ng7m92	456	6	stem	stem	NN
cord-262445-54ng7m92	456	7	cells	cell	NNS
cord-262445-54ng7m92	456	8	allowed	allow	VBD
cord-262445-54ng7m92	456	9	the	the	DT
cord-262445-54ng7m92	456	10	opportunities	opportunity	NNS
cord-262445-54ng7m92	456	11	to	to	TO
cord-262445-54ng7m92	456	12	generate	generate	VB
cord-262445-54ng7m92	456	13	tissues	tissue	NNS
cord-262445-54ng7m92	456	14	from	from	IN
cord-262445-54ng7m92	456	15	combinations	combination	NNS
cord-262445-54ng7m92	456	16	of	of	IN
cord-262445-54ng7m92	456	17	engineered	engineer	VBN
cord-262445-54ng7m92	456	18	extracellular	extracellular	JJ
cord-262445-54ng7m92	456	19	matrices	matrix	NNS
cord-262445-54ng7m92	456	20	,	,	,
cord-262445-54ng7m92	456	21	cells	cell	NNS
cord-262445-54ng7m92	456	22	and	and	CC
cord-262445-54ng7m92	456	23	biologically	biologically	RB
cord-262445-54ng7m92	456	24	active	active	JJ
cord-262445-54ng7m92	456	25	molecules	molecule	NNS
cord-262445-54ng7m92	456	26	in	in	IN
cord-262445-54ng7m92	456	27	order	order	NN
cord-262445-54ng7m92	456	28	to	to	TO
cord-262445-54ng7m92	456	29	promote	promote	VB
cord-262445-54ng7m92	456	30	muscle	muscle	NN
cord-262445-54ng7m92	456	31	regenerative	regenerative	JJ
cord-262445-54ng7m92	456	32	response	response	NN
cord-262445-54ng7m92	456	33	.	.	.
cord-262445-54ng7m92	457	1	Therefore	therefore	RB
cord-262445-54ng7m92	457	2	,	,	,
cord-262445-54ng7m92	457	3	functional	functional	JJ
cord-262445-54ng7m92	457	4	contractile	contractile	JJ
cord-262445-54ng7m92	457	5	properties	property	NNS
cord-262445-54ng7m92	457	6	as	as	RB
cord-262445-54ng7m92	457	7	close	close	JJ
cord-262445-54ng7m92	457	8	as	as	IN
cord-262445-54ng7m92	457	9	possible	possible	JJ
cord-262445-54ng7m92	457	10	to	to	IN
cord-262445-54ng7m92	457	11	that	that	DT
cord-262445-54ng7m92	457	12	of	of	IN
cord-262445-54ng7m92	457	13	healthy	healthy	JJ
cord-262445-54ng7m92	457	14	muscles	muscle	NNS
cord-262445-54ng7m92	457	15	are	be	VBP
cord-262445-54ng7m92	457	16	requested	request	VBN
cord-262445-54ng7m92	457	17	to	to	TO
cord-262445-54ng7m92	457	18	allow	allow	VB
cord-262445-54ng7m92	457	19	for	for	IN
cord-262445-54ng7m92	457	20	a	a	DT
cord-262445-54ng7m92	457	21	good	good	JJ
cord-262445-54ng7m92	457	22	compatibility	compatibility	NN
cord-262445-54ng7m92	457	23	and	and	CC
cord-262445-54ng7m92	457	24	a	a	DT
cord-262445-54ng7m92	457	25	proper	proper	JJ
cord-262445-54ng7m92	457	26	functional	functional	JJ
cord-262445-54ng7m92	457	27	contribution	contribution	NN
cord-262445-54ng7m92	457	28	.	.	.
cord-262445-54ng7m92	458	1	The	the	DT
cord-262445-54ng7m92	458	2	X	X	NNP
cord-262445-54ng7m92	458	3	-	-	HYPH
cord-262445-54ng7m92	458	4	MET	MET	NNP
cord-262445-54ng7m92	458	5	is	be	VBZ
cord-262445-54ng7m92	458	6	an	an	DT
cord-262445-54ng7m92	458	7	engineering	engineering	NN
cord-262445-54ng7m92	458	8	vascularized	vascularized	JJ
cord-262445-54ng7m92	458	9	skeletal	skeletal	JJ
cord-262445-54ng7m92	458	10	muscle	muscle	NN
cord-262445-54ng7m92	458	11	tissue	tissue	NN
cord-262445-54ng7m92	458	12	able	able	JJ
cord-262445-54ng7m92	458	13	to	to	TO
cord-262445-54ng7m92	458	14	recapitulate	recapitulate	VB
cord-262445-54ng7m92	458	15	the	the	DT
cord-262445-54ng7m92	458	16	complex	complex	JJ
cord-262445-54ng7m92	458	17	morphological	morphological	JJ
cord-262445-54ng7m92	458	18	properties	property	NNS
cord-262445-54ng7m92	458	19	,	,	,
cord-262445-54ng7m92	458	20	the	the	DT
cord-262445-54ng7m92	458	21	architecture	architecture	NN
cord-262445-54ng7m92	458	22	and	and	CC
cord-262445-54ng7m92	458	23	the	the	DT
cord-262445-54ng7m92	458	24	function	function	NN
cord-262445-54ng7m92	458	25	of	of	IN
cord-262445-54ng7m92	458	26	skeletal	skeletal	JJ
cord-262445-54ng7m92	458	27	muscle	muscle	NN
cord-262445-54ng7m92	458	28	.	.	.
cord-262445-54ng7m92	459	1	The	the	DT
cord-262445-54ng7m92	459	2	X	X	NNP
cord-262445-54ng7m92	459	3	-	-	HYPH
cord-262445-54ng7m92	459	4	MET	MET	NNP
cord-262445-54ng7m92	459	5	shows	show	VBZ
cord-262445-54ng7m92	459	6	biomechanical	biomechanical	JJ
cord-262445-54ng7m92	459	7	properties	property	NNS
cord-262445-54ng7m92	459	8	like	like	IN
cord-262445-54ng7m92	459	9	muscles	muscle	NNS
cord-262445-54ng7m92	459	10	,	,	,
cord-262445-54ng7m92	459	11	can	can	MD
cord-262445-54ng7m92	459	12	contract	contract	VB
cord-262445-54ng7m92	459	13	spontaneously	spontaneously	RB
cord-262445-54ng7m92	459	14	as	as	RB
cord-262445-54ng7m92	459	15	well	well	RB
cord-262445-54ng7m92	459	16	as	as	IN
cord-262445-54ng7m92	459	17	to	to	TO
cord-262445-54ng7m92	459	18	respond	respond	VB
cord-262445-54ng7m92	459	19	to	to	IN
cord-262445-54ng7m92	459	20	electrical	electrical	JJ
cord-262445-54ng7m92	459	21	stimulation	stimulation	NN
cord-262445-54ng7m92	459	22	.	.	.
cord-262445-54ng7m92	460	1	The	the	DT
cord-262445-54ng7m92	460	2	aim	aim	NN
cord-262445-54ng7m92	460	3	of	of	IN
cord-262445-54ng7m92	460	4	our	-PRON-	PRP$
cord-262445-54ng7m92	460	5	study	study	NN
cord-262445-54ng7m92	460	6	is	be	VBZ
cord-262445-54ng7m92	460	7	to	to	TO
cord-262445-54ng7m92	460	8	define	define	VB
cord-262445-54ng7m92	460	9	the	the	DT
cord-262445-54ng7m92	460	10	functional	functional	JJ
cord-262445-54ng7m92	460	11	plasticity	plasticity	NN
cord-262445-54ng7m92	460	12	of	of	IN
cord-262445-54ng7m92	460	13	X	X	NNP
cord-262445-54ng7m92	460	14	-	-	:
cord-262445-54ng7m92	460	15	MET	MET	NNP
cord-262445-54ng7m92	460	16	subjected	subject	VBN
cord-262445-54ng7m92	460	17	to	to	IN
cord-262445-54ng7m92	460	18	mechanical	mechanical	JJ
cord-262445-54ng7m92	460	19	stimuli	stimulus	NNS
cord-262445-54ng7m92	460	20	.	.	.
cord-262445-54ng7m92	461	1	Interestingly	interestingly	RB
cord-262445-54ng7m92	461	2	,	,	,
cord-262445-54ng7m92	461	3	preliminary	preliminary	JJ
cord-262445-54ng7m92	461	4	evidences	evidence	NNS
cord-262445-54ng7m92	461	5	suggest	suggest	VBP
cord-262445-54ng7m92	461	6	that	that	IN
cord-262445-54ng7m92	461	7	different	different	JJ
cord-262445-54ng7m92	461	8	mechanical	mechanical	JJ
cord-262445-54ng7m92	461	9	tensions	tension	NNS
cord-262445-54ng7m92	461	10	induce	induce	VBP
cord-262445-54ng7m92	461	11	a	a	DT
cord-262445-54ng7m92	461	12	functional	functional	JJ
cord-262445-54ng7m92	461	13	remodeling	remodeling	NN
cord-262445-54ng7m92	461	14	of	of	IN
cord-262445-54ng7m92	461	15	X	x	NN
cord-262445-54ng7m92	461	16	-	-	:
cord-262445-54ng7m92	461	17	MET	MET	NNP
cord-262445-54ng7m92	461	18	toward	toward	IN
cord-262445-54ng7m92	461	19	a	a	DT
cord-262445-54ng7m92	461	20	non	non	JJ
cord-262445-54ng7m92	461	21	-	-	JJ
cord-262445-54ng7m92	461	22	skeletal	skeletal	JJ
cord-262445-54ng7m92	461	23	muscle	muscle	NN
cord-262445-54ng7m92	461	24	phenotype	phenotype	NN
cord-262445-54ng7m92	461	25	.	.	.
cord-262445-54ng7m92	462	1	In	in	IN
cord-262445-54ng7m92	462	2	this	this	DT
cord-262445-54ng7m92	462	3	work	work	NN
cord-262445-54ng7m92	462	4	,	,	,
cord-262445-54ng7m92	462	5	we	-PRON-	PRP
cord-262445-54ng7m92	462	6	demonstrated	demonstrate	VBD
cord-262445-54ng7m92	462	7	that	that	IN
cord-262445-54ng7m92	462	8	X	X	NNP
cord-262445-54ng7m92	462	9	-	-	HYPH
cord-262445-54ng7m92	462	10	MET	MET	NNP
cord-262445-54ng7m92	462	11	show	show	NN
cord-262445-54ng7m92	462	12	preserved	preserve	VBD
cord-262445-54ng7m92	462	13	cellular	cellular	JJ
cord-262445-54ng7m92	462	14	communication	communication	NN
cord-262445-54ng7m92	462	15	junctions	junction	NNS
cord-262445-54ng7m92	462	16	,	,	,
cord-262445-54ng7m92	462	17	endogenous	endogenous	JJ
cord-262445-54ng7m92	462	18	extracellular	extracellular	JJ
cord-262445-54ng7m92	462	19	matrix	matrix	NN
cord-262445-54ng7m92	462	20	(	(	-LRB-
cord-262445-54ng7m92	462	21	ECM	ECM	NNP
cord-262445-54ng7m92	462	22	)	)	-RRB-
cord-262445-54ng7m92	462	23	,	,	,
cord-262445-54ng7m92	462	24	and	and	CC
cord-262445-54ng7m92	462	25	integrative	integrative	JJ
cord-262445-54ng7m92	462	26	adhesive	adhesive	JJ
cord-262445-54ng7m92	462	27	agents	agent	NNS
cord-262445-54ng7m92	462	28	that	that	WDT
cord-262445-54ng7m92	462	29	could	could	MD
cord-262445-54ng7m92	462	30	create	create	VB
cord-262445-54ng7m92	462	31	a	a	DT
cord-262445-54ng7m92	462	32	favorable	favorable	JJ
cord-262445-54ng7m92	462	33	environment	environment	NN
cord-262445-54ng7m92	462	34	for	for	IN
cord-262445-54ng7m92	462	35	survival	survival	NN
cord-262445-54ng7m92	462	36	and	and	CC
cord-262445-54ng7m92	462	37	integration	integration	NN
cord-262445-54ng7m92	462	38	of	of	IN
cord-262445-54ng7m92	462	39	the	the	DT
cord-262445-54ng7m92	462	40	X	X	NNP
cord-262445-54ng7m92	462	41	-	-	NNP
cord-262445-54ng7m92	462	42	MET	MET	NNP
cord-262445-54ng7m92	462	43	in	in	IN
cord-262445-54ng7m92	462	44	the	the	DT
cord-262445-54ng7m92	462	45	host	host	NN
cord-262445-54ng7m92	462	46	tissue	tissue	NN
cord-262445-54ng7m92	462	47	.	.	.
cord-262445-54ng7m92	463	1	For	for	IN
cord-262445-54ng7m92	463	2	this	this	DT
cord-262445-54ng7m92	463	3	features	feature	NNS
cord-262445-54ng7m92	463	4	,	,	,
cord-262445-54ng7m92	463	5	X	X	NNP
cord-262445-54ng7m92	463	6	-	-	:
cord-262445-54ng7m92	463	7	MET	MET	NNP
cord-262445-54ng7m92	463	8	can	can	MD
cord-262445-54ng7m92	463	9	be	be	VB
cord-262445-54ng7m92	463	10	considered	consider	VBN
cord-262445-54ng7m92	463	11	a	a	DT
cord-262445-54ng7m92	463	12	useful	useful	JJ
cord-262445-54ng7m92	463	13	experimental	experimental	JJ
cord-262445-54ng7m92	463	14	tool	tool	NN
cord-262445-54ng7m92	463	15	for	for	IN
cord-262445-54ng7m92	463	16	in	in	FW
cord-262445-54ng7m92	463	17	vitro	vitro	FW
cord-262445-54ng7m92	463	18	and	and	CC
cord-262445-54ng7m92	463	19	in	in	IN
cord-262445-54ng7m92	463	20	vivo	vivo	NNP
cord-262445-54ng7m92	463	21	studies	study	NNS
cord-262445-54ng7m92	463	22	to	to	TO
cord-262445-54ng7m92	463	23	improve	improve	VB
cord-262445-54ng7m92	463	24	drug	drug	NN
cord-262445-54ng7m92	463	25	discovery	discovery	NN
cord-262445-54ng7m92	463	26	technologies	technology	NNS
cord-262445-54ng7m92	463	27	,	,	,
cord-262445-54ng7m92	463	28	to	to	TO
cord-262445-54ng7m92	463	29	supersede	supersede	VB
cord-262445-54ng7m92	463	30	current	current	JJ
cord-262445-54ng7m92	463	31	preclinical	preclinical	JJ
cord-262445-54ng7m92	463	32	animal	animal	NN
cord-262445-54ng7m92	463	33	models	model	NNS
cord-262445-54ng7m92	463	34	of	of	IN
cord-262445-54ng7m92	463	35	disease	disease	NN
cord-262445-54ng7m92	463	36	and	and	CC
cord-262445-54ng7m92	463	37	to	to	TO
cord-262445-54ng7m92	463	38	restore	restore	VB
cord-262445-54ng7m92	463	39	the	the	DT
cord-262445-54ng7m92	463	40	lost	lost	JJ
cord-262445-54ng7m92	463	41	function	function	NN
cord-262445-54ng7m92	463	42	of	of	IN
cord-262445-54ng7m92	463	43	muscles	muscle	NNS
cord-262445-54ng7m92	463	44	.	.	.
cord-262445-54ng7m92	464	1	Sertoli	sertoli	JJ
cord-262445-54ng7m92	464	2	cells	cell	NNS
cord-262445-54ng7m92	464	3	(	(	-LRB-
cord-262445-54ng7m92	464	4	SeC	SeC	NNP
cord-262445-54ng7m92	464	5	)	)	-RRB-
cord-262445-54ng7m92	464	6	are	be	VBP
cord-262445-54ng7m92	464	7	the	the	DT
cord-262445-54ng7m92	464	8	major	major	JJ
cord-262445-54ng7m92	464	9	component	component	NN
cord-262445-54ng7m92	464	10	of	of	IN
cord-262445-54ng7m92	464	11	the	the	DT
cord-262445-54ng7m92	464	12	seminiferous	seminiferous	JJ
cord-262445-54ng7m92	464	13	tubules	tubule	NNS
cord-262445-54ng7m92	464	14	in	in	IN
cord-262445-54ng7m92	464	15	the	the	DT
cord-262445-54ng7m92	464	16	testes	testis	NNS
cord-262445-54ng7m92	464	17	,	,	,
cord-262445-54ng7m92	464	18	where	where	WRB
cord-262445-54ng7m92	464	19	they	-PRON-	PRP
cord-262445-54ng7m92	464	20	secrete	secrete	VBP
cord-262445-54ng7m92	464	21	a	a	DT
cord-262445-54ng7m92	464	22	plethora	plethora	NN
cord-262445-54ng7m92	464	23	of	of	IN
cord-262445-54ng7m92	464	24	trophic	trophic	NN
cord-262445-54ng7m92	464	25	and	and	CC
cord-262445-54ng7m92	464	26	immunomodulatory	immunomodulatory	JJ
cord-262445-54ng7m92	464	27	factors	factor	NNS
cord-262445-54ng7m92	464	28	necessary	necessary	JJ
cord-262445-54ng7m92	464	29	for	for	IN
cord-262445-54ng7m92	464	30	development	development	NN
cord-262445-54ng7m92	464	31	of	of	IN
cord-262445-54ng7m92	464	32	germ	germ	NN
cord-262445-54ng7m92	464	33	cells	cell	NNS
cord-262445-54ng7m92	464	34	and	and	CC
cord-262445-54ng7m92	464	35	to	to	TO
cord-262445-54ng7m92	464	36	protect	protect	VB
cord-262445-54ng7m92	464	37	developing	develop	VBG
cord-262445-54ng7m92	464	38	germ	germ	NN
cord-262445-54ng7m92	464	39	cells	cell	NNS
cord-262445-54ng7m92	464	40	against	against	IN
cord-262445-54ng7m92	464	41	the	the	DT
cord-262445-54ng7m92	464	42	immune	immune	JJ
cord-262445-54ng7m92	464	43	system	system	NN
cord-262445-54ng7m92	464	44	attack	attack	NN
cord-262445-54ng7m92	464	45	,	,	,
cord-262445-54ng7m92	464	46	respectively	respectively	RB
cord-262445-54ng7m92	464	47	.	.	.
cord-262445-54ng7m92	465	1	Naked	naked	JJ
cord-262445-54ng7m92	465	2	or	or	CC
cord-262445-54ng7m92	465	3	encapsulated	encapsulate	VBN
cord-262445-54ng7m92	465	4	SeC	sec	NN
cord-262445-54ng7m92	465	5	have	have	VBP
cord-262445-54ng7m92	465	6	been	be	VBN
cord-262445-54ng7m92	465	7	widely	widely	RB
cord-262445-54ng7m92	465	8	used	use	VBN
cord-262445-54ng7m92	465	9	as	as	IN
cord-262445-54ng7m92	465	10	a	a	DT
cord-262445-54ng7m92	465	11	therapeutic	therapeutic	JJ
cord-262445-54ng7m92	465	12	approach	approach	NN
cord-262445-54ng7m92	465	13	to	to	IN
cord-262445-54ng7m92	465	14	many	many	JJ
cord-262445-54ng7m92	465	15	pre	pre	JJ
cord-262445-54ng7m92	465	16	-	-	JJ
cord-262445-54ng7m92	465	17	clinical	clinical	JJ
cord-262445-54ng7m92	465	18	studies	study	NNS
cord-262445-54ng7m92	465	19	[	[	-LRB-
cord-262445-54ng7m92	465	20	1	1	CD
cord-262445-54ng7m92	465	21	,	,	,
cord-262445-54ng7m92	465	22	2	2	CD
cord-262445-54ng7m92	465	23	]	]	-RRB-
cord-262445-54ng7m92	465	24	.	.	.
cord-262445-54ng7m92	466	1	A	a	DT
cord-262445-54ng7m92	466	2	single	single	JJ
cord-262445-54ng7m92	466	3	intraperitoneal	intraperitoneal	NN
cord-262445-54ng7m92	466	4	(	(	-LRB-
cord-262445-54ng7m92	466	5	i.p	i.p	NNP
cord-262445-54ng7m92	466	6	.	.	NNP
cord-262445-54ng7m92	466	7	)	)	-RRB-
cord-262445-54ng7m92	466	8	injection	injection	NN
cord-262445-54ng7m92	466	9	of	of	IN
cord-262445-54ng7m92	466	10	microencapsulated	microencapsulated	JJ
cord-262445-54ng7m92	466	11	porcine	porcine	JJ
cord-262445-54ng7m92	466	12	SeC	sec	NN
cord-262445-54ng7m92	466	13	(	(	-LRB-
cord-262445-54ng7m92	466	14	SeC	SeC	NNP
cord-262445-54ng7m92	466	15	-	-	HYPH
cord-262445-54ng7m92	466	16	MC	MC	NNP
cord-262445-54ng7m92	466	17	)	)	-RRB-
cord-262445-54ng7m92	466	18	translated	translate	VBD
cord-262445-54ng7m92	466	19	into	into	IN
cord-262445-54ng7m92	466	20	recovery	recovery	NN
cord-262445-54ng7m92	466	21	of	of	IN
cord-262445-54ng7m92	466	22	muscle	muscle	NN
cord-262445-54ng7m92	466	23	morphology	morphology	NN
cord-262445-54ng7m92	466	24	and	and	CC
cord-262445-54ng7m92	466	25	performance	performance	NN
cord-262445-54ng7m92	466	26	in	in	IN
cord-262445-54ng7m92	466	27	dystrophic	dystrophic	NNP
cord-262445-54ng7m92	466	28	(	(	-LRB-
cord-262445-54ng7m92	466	29	mdx	mdx	NNP
cord-262445-54ng7m92	466	30	)	)	-RRB-
cord-262445-54ng7m92	466	31	mice	mouse	NNS
cord-262445-54ng7m92	466	32	in	in	IN
cord-262445-54ng7m92	466	33	the	the	DT
cord-262445-54ng7m92	466	34	absence	absence	NN
cord-262445-54ng7m92	466	35	of	of	IN
cord-262445-54ng7m92	466	36	pharmacological	pharmacological	JJ
cord-262445-54ng7m92	466	37	immunosuppression	immunosuppression	NN
cord-262445-54ng7m92	466	38	,	,	,
cord-262445-54ng7m92	466	39	thanks	thank	NNS
cord-262445-54ng7m92	466	40	to	to	IN
cord-262445-54ng7m92	466	41	a	a	DT
cord-262445-54ng7m92	466	42	double	double	JJ
cord-262445-54ng7m92	466	43	SeC	sec	NN
cord-262445-54ng7m92	466	44	effect	effect	NN
cord-262445-54ng7m92	466	45	,	,	,
cord-262445-54ng7m92	466	46	i.e.	i.e.	FW
cord-262445-54ng7m92	466	47	,	,	,
cord-262445-54ng7m92	466	48	an	an	DT
cord-262445-54ng7m92	466	49	antiinflammatory	antiinflammatory	JJ
cord-262445-54ng7m92	466	50	action	action	NN
cord-262445-54ng7m92	466	51	and	and	CC
cord-262445-54ng7m92	466	52	heregulin	heregulin	NNP
cord-262445-54ng7m92	466	53	beta	beta	NNP
cord-262445-54ng7m92	466	54	1-dependent	1-dependent	CD
cord-262445-54ng7m92	466	55	induction	induction	NN
cord-262445-54ng7m92	466	56	of	of	IN
cord-262445-54ng7m92	466	57	utrophin	utrophin	NN
cord-262445-54ng7m92	466	58	at	at	IN
cord-262445-54ng7m92	466	59	the	the	DT
cord-262445-54ng7m92	466	60	sarcolemma	sarcolemma	NNP
cord-262445-54ng7m92	466	61	[	[	-LRB-
cord-262445-54ng7m92	466	62	3	3	CD
cord-262445-54ng7m92	466	63	]	]	-RRB-
cord-262445-54ng7m92	466	64	.	.	.
cord-262445-54ng7m92	467	1	This	this	DT
cord-262445-54ng7m92	467	2	opened	open	VBD
cord-262445-54ng7m92	467	3	a	a	DT
cord-262445-54ng7m92	467	4	new	new	JJ
cord-262445-54ng7m92	467	5	route	route	NN
cord-262445-54ng7m92	467	6	of	of	IN
cord-262445-54ng7m92	467	7	treatment	treatment	NN
cord-262445-54ng7m92	467	8	for	for	IN
cord-262445-54ng7m92	467	9	Duchenne	Duchenne	NNP
cord-262445-54ng7m92	467	10	muscular	muscular	JJ
cord-262445-54ng7m92	467	11	dystrophy	dystrophy	NN
cord-262445-54ng7m92	467	12	(	(	-LRB-
cord-262445-54ng7m92	467	13	DMD	DMD	NNP
cord-262445-54ng7m92	467	14	)	)	-RRB-
cord-262445-54ng7m92	467	15	patients	patient	NNS
cord-262445-54ng7m92	467	16	.	.	.
cord-262445-54ng7m92	468	1	However	however	RB
cord-262445-54ng7m92	468	2	,	,	,
cord-262445-54ng7m92	468	3	it	-PRON-	PRP
cord-262445-54ng7m92	468	4	is	be	VBZ
cord-262445-54ng7m92	468	5	still	still	RB
cord-262445-54ng7m92	468	6	debating	debate	VBG
cord-262445-54ng7m92	468	7	if	if	IN
cord-262445-54ng7m92	468	8	SeC	SeC	NNP
cord-262445-54ng7m92	468	9	exert	exert	VBP
cord-262445-54ng7m92	468	10	immunomodulatory	immunomodulatory	JJ
cord-262445-54ng7m92	468	11	or	or	CC
cord-262445-54ng7m92	468	12	immunosuppressive	immunosuppressive	JJ
cord-262445-54ng7m92	468	13	effects	effect	NNS
cord-262445-54ng7m92	468	14	,	,	,
cord-262445-54ng7m92	468	15	which	which	WDT
cord-262445-54ng7m92	468	16	is	be	VBZ
cord-262445-54ng7m92	468	17	of	of	IN
cord-262445-54ng7m92	468	18	relevance	relevance	NN
cord-262445-54ng7m92	468	19	in	in	IN
cord-262445-54ng7m92	468	20	view	view	NN
cord-262445-54ng7m92	468	21	of	of	IN
cord-262445-54ng7m92	468	22	their	-PRON-	PRP$
cord-262445-54ng7m92	468	23	application	application	NN
cord-262445-54ng7m92	468	24	in	in	IN
cord-262445-54ng7m92	468	25	humans	human	NNS
cord-262445-54ng7m92	468	26	.	.	.
cord-262445-54ng7m92	469	1	Here	here	RB
cord-262445-54ng7m92	469	2	we	-PRON-	PRP
cord-262445-54ng7m92	469	3	show	show	VBP
cord-262445-54ng7m92	469	4	that	that	IN
cord-262445-54ng7m92	469	5	mice	mouse	NNS
cord-262445-54ng7m92	469	6	previously	previously	RB
cord-262445-54ng7m92	469	7	injected	inject	VBD
cord-262445-54ng7m92	469	8	i.p	i.p	NNP
cord-262445-54ng7m92	469	9	.	.	NNP
cord-262445-54ng7m92	469	10	with	with	IN
cord-262445-54ng7m92	469	11	SeC	SeC	NNP
cord-262445-54ng7m92	469	12	-	-	HYPH
cord-262445-54ng7m92	469	13	MC	MC	NNP
cord-262445-54ng7m92	469	14	were	be	VBD
cord-262445-54ng7m92	469	15	more	more	RBR
cord-262445-54ng7m92	469	16	able	able	JJ
cord-262445-54ng7m92	469	17	to	to	TO
cord-262445-54ng7m92	469	18	solve	solve	VB
cord-262445-54ng7m92	469	19	pulmonary	pulmonary	JJ
cord-262445-54ng7m92	469	20	infection	infection	NN
cord-262445-54ng7m92	469	21	by	by	IN
cord-262445-54ng7m92	469	22	Aspergillus	aspergillus	NN
cord-262445-54ng7m92	469	23	fumigatus	fumigatus	NN
cord-262445-54ng7m92	469	24	,	,	,
cord-262445-54ng7m92	469	25	one	one	CD
cord-262445-54ng7m92	469	26	of	of	IN
cord-262445-54ng7m92	469	27	the	the	DT
cord-262445-54ng7m92	469	28	most	most	RBS
cord-262445-54ng7m92	469	29	common	common	JJ
cord-262445-54ng7m92	469	30	species	specie	NNS
cord-262445-54ng7m92	469	31	causing	cause	VBG
cord-262445-54ng7m92	469	32	disease	disease	NN
cord-262445-54ng7m92	469	33	in	in	IN
cord-262445-54ng7m92	469	34	immunodeficient	immunodeficient	JJ
cord-262445-54ng7m92	469	35	individuals	individual	NNS
cord-262445-54ng7m92	469	36	,	,	,
cord-262445-54ng7m92	469	37	compared	compare	VBN
cord-262445-54ng7m92	469	38	to	to	IN
cord-262445-54ng7m92	469	39	control	control	NN
cord-262445-54ng7m92	469	40	mice	mouse	NNS
cord-262445-54ng7m92	469	41	injected	inject	VBN
cord-262445-54ng7m92	469	42	with	with	IN
cord-262445-54ng7m92	469	43	empty	empty	JJ
cord-262445-54ng7m92	469	44	microcapsules	microcapsule	NNS
cord-262445-54ng7m92	470	1	(	(	-LRB-
cord-262445-54ng7m92	470	2	E	E	NNP
cord-262445-54ng7m92	470	3	-	-	NNP
cord-262445-54ng7m92	470	4	MC	MC	NNP
cord-262445-54ng7m92	470	5	)	)	-RRB-
cord-262445-54ng7m92	470	6	,	,	,
cord-262445-54ng7m92	470	7	as	as	IN
cord-262445-54ng7m92	470	8	evaluated	evaluate	VBN
cord-262445-54ng7m92	470	9	by	by	IN
cord-262445-54ng7m92	470	10	analysis	analysis	NN
cord-262445-54ng7m92	470	11	of	of	IN
cord-262445-54ng7m92	470	12	bronchoalveolar	bronchoalveolar	NNP
cord-262445-54ng7m92	470	13	lavage	lavage	NN
cord-262445-54ng7m92	470	14	,	,	,
cord-262445-54ng7m92	470	15	fungal	fungal	JJ
cord-262445-54ng7m92	470	16	growth	growth	NN
cord-262445-54ng7m92	470	17	,	,	,
cord-262445-54ng7m92	470	18	histology	histology	NN
cord-262445-54ng7m92	470	19	(	(	-LRB-
cord-262445-54ng7m92	470	20	PAS	pas	NN
cord-262445-54ng7m92	470	21	and	and	CC
cord-262445-54ng7m92	470	22	Grocott	Grocott	NNP
cord-262445-54ng7m92	470	23	staining	stain	VBG
cord-262445-54ng7m92	470	24	)	)	-RRB-
cord-262445-54ng7m92	470	25	,	,	,
cord-262445-54ng7m92	470	26	and	and	CC
cord-262445-54ng7m92	470	27	inflammatory	inflammatory	JJ
cord-262445-54ng7m92	470	28	chemokines	chemokine	NNS
cord-262445-54ng7m92	470	29	and	and	CC
cord-262445-54ng7m92	470	30	cytokines	cytokine	NNS
cord-262445-54ng7m92	470	31	expression	expression	NN
cord-262445-54ng7m92	470	32	(	(	-LRB-
cord-262445-54ng7m92	470	33	RT	RT	NNP
cord-262445-54ng7m92	470	34	-	-	HYPH
cord-262445-54ng7m92	470	35	PCR	PCR	NNP
cord-262445-54ng7m92	470	36	)	)	-RRB-
cord-262445-54ng7m92	470	37	in	in	IN
cord-262445-54ng7m92	470	38	lungs	lung	NNS
cord-262445-54ng7m92	470	39	.	.	.
cord-262445-54ng7m92	471	1	Moreover	moreover	RB
cord-262445-54ng7m92	471	2	,	,	,
cord-262445-54ng7m92	471	3	mice	mouse	NNS
cord-262445-54ng7m92	471	4	previously	previously	RB
cord-262445-54ng7m92	471	5	injected	inject	VBD
cord-262445-54ng7m92	471	6	i.p	i.p	NNP
cord-262445-54ng7m92	471	7	.	.	NNP
cord-262445-54ng7m92	471	8	with	with	IN
cord-262445-54ng7m92	471	9	SeC	SeC	NNP
cord-262445-54ng7m92	471	10	-	-	HYPH
cord-262445-54ng7m92	471	11	MC	MC	NNP
cord-262445-54ng7m92	471	12	and	and	CC
cord-262445-54ng7m92	471	13	later	later	RB
cord-262445-54ng7m92	471	14	injected	inject	VBD
cord-262445-54ng7m92	471	15	subcutaneously	subcutaneously	RB
cord-262445-54ng7m92	471	16	with	with	IN
cord-262445-54ng7m92	471	17	LLC	LLC	NNP
cord-262445-54ng7m92	471	18	(	(	-LRB-
cord-262445-54ng7m92	471	19	Lewis	Lewis	NNP
cord-262445-54ng7m92	471	20	lung	lung	NN
cord-262445-54ng7m92	471	21	carcinoma	carcinoma	NN
cord-262445-54ng7m92	471	22	)	)	-RRB-
cord-262445-54ng7m92	471	23	cells	cell	NNS
cord-262445-54ng7m92	471	24	showed	show	VBD
cord-262445-54ng7m92	471	25	similar	similar	JJ
cord-262445-54ng7m92	471	26	tumor	tumor	NN
cord-262445-54ng7m92	471	27	growth	growth	NN
cord-262445-54ng7m92	471	28	over	over	IN
cord-262445-54ng7m92	471	29	time	time	NN
cord-262445-54ng7m92	471	30	to	to	IN
cord-262445-54ng7m92	471	31	mice	mouse	NNS
cord-262445-54ng7m92	471	32	injected	inject	VBN
cord-262445-54ng7m92	471	33	with	with	IN
cord-262445-54ng7m92	471	34	E	E	NNP
cord-262445-54ng7m92	471	35	-	-	NNP
cord-262445-54ng7m92	471	36	MC	MC	NNP
cord-262445-54ng7m92	471	37	,	,	,
cord-262445-54ng7m92	471	38	further	further	RB
cord-262445-54ng7m92	471	39	suggesting	suggest	VBG
cord-262445-54ng7m92	471	40	that	that	IN
cord-262445-54ng7m92	471	41	SeC	SeC	NNP
cord-262445-54ng7m92	471	42	do	do	VBP
cord-262445-54ng7m92	471	43	not	not	RB
cord-262445-54ng7m92	471	44	exert	exert	VB
cord-262445-54ng7m92	471	45	an	an	DT
cord-262445-54ng7m92	471	46	immunosuppressive	immunosuppressive	JJ
cord-262445-54ng7m92	471	47	role	role	NN
cord-262445-54ng7m92	471	48	.	.	.
cord-262445-54ng7m92	472	1	This	this	DT
cord-262445-54ng7m92	472	2	was	be	VBD
cord-262445-54ng7m92	472	3	also	also	RB
cord-262445-54ng7m92	472	4	confirmed	confirm	VBN
cord-262445-54ng7m92	472	5	by	by	IN
cord-262445-54ng7m92	472	6	the	the	DT
cord-262445-54ng7m92	472	7	observation	observation	NN
cord-262445-54ng7m92	472	8	that	that	IN
cord-262445-54ng7m92	472	9	one	one	CD
cord-262445-54ng7m92	472	10	year	year	NN
cord-262445-54ng7m92	472	11	from	from	IN
cord-262445-54ng7m92	472	12	i.p	i.p	NNP
cord-262445-54ng7m92	472	13	.	.	NNP
cord-262445-54ng7m92	472	14	injection	injection	NNP
cord-262445-54ng7m92	472	15	SeC	SeC	NNP
cord-262445-54ng7m92	472	16	-	-	HYPH
cord-262445-54ng7m92	472	17	MC	MC	NNP
cord-262445-54ng7m92	472	18	-	-	HYPH
cord-262445-54ng7m92	472	19	injected	inject	VBN
cord-262445-54ng7m92	472	20	mdx	mdx	NNP
cord-262445-54ng7m92	472	21	mice	mouse	NNS
cord-262445-54ng7m92	472	22	did	do	VBD
cord-262445-54ng7m92	472	23	not	not	RB
cord-262445-54ng7m92	472	24	show	show	VB
cord-262445-54ng7m92	472	25	neither	neither	CC
cord-262445-54ng7m92	472	26	adverse	adverse	JJ
cord-262445-54ng7m92	472	27	effects	effect	NNS
cord-262445-54ng7m92	472	28	nor	nor	CC
cord-262445-54ng7m92	472	29	increased	increase	VBN
cord-262445-54ng7m92	472	30	incidence	incidence	NN
cord-262445-54ng7m92	472	31	of	of	IN
cord-262445-54ng7m92	472	32	tumor	tumor	NN
cord-262445-54ng7m92	472	33	formation	formation	NN
cord-262445-54ng7m92	472	34	.	.	.
cord-262445-54ng7m92	473	1	Altogether	altogether	RB
cord-262445-54ng7m92	473	2	,	,	,
cord-262445-54ng7m92	473	3	our	-PRON-	PRP$
cord-262445-54ng7m92	473	4	data	datum	NNS
cord-262445-54ng7m92	473	5	suggest	suggest	VBP
cord-262445-54ng7m92	473	6	that	that	IN
cord-262445-54ng7m92	473	7	SeC	SeC	NNP
cord-262445-54ng7m92	473	8	exert	exert	VB
cord-262445-54ng7m92	473	9	immunomodulatory	immunomodulatory	NNP
cord-262445-54ng7m92	473	10	rather	rather	RB
cord-262445-54ng7m92	473	11	than	than	IN
cord-262445-54ng7m92	473	12	immunosuppressive	immunosuppressive	JJ
cord-262445-54ng7m92	473	13	effect	effect	NN
cord-262445-54ng7m92	473	14	,	,	,
cord-262445-54ng7m92	473	15	further	further	RB
cord-262445-54ng7m92	473	16	supporting	support	VBG
cord-262445-54ng7m92	473	17	the	the	DT
cord-262445-54ng7m92	473	18	use	use	NN
cord-262445-54ng7m92	473	19	of	of	IN
cord-262445-54ng7m92	473	20	i.p	i.p	NNP
cord-262445-54ng7m92	473	21	.	.	NNP
cord-262445-54ng7m92	473	22	injection	injection	NN
cord-262445-54ng7m92	473	23	of	of	IN
cord-262445-54ng7m92	473	24	SeC	SeC	NNP
cord-262445-54ng7m92	473	25	-	-	HYPH
cord-262445-54ng7m92	473	26	MC	MC	NNP
cord-262445-54ng7m92	473	27	as	as	IN
cord-262445-54ng7m92	473	28	a	a	DT
cord-262445-54ng7m92	473	29	potential	potential	JJ
cord-262445-54ng7m92	473	30	treatment	treatment	NN
cord-262445-54ng7m92	473	31	of	of	IN
cord-262445-54ng7m92	473	32	DMD	DMD	NNP
cord-262445-54ng7m92	473	33	patients	patient	NNS
cord-262445-54ng7m92	473	34	and	and	CC
cord-262445-54ng7m92	473	35	diseases	disease	NNS
cord-262445-54ng7m92	473	36	characterized	characterize	VBN
cord-262445-54ng7m92	473	37	by	by	IN
cord-262445-54ng7m92	473	38	an	an	DT
cord-262445-54ng7m92	473	39	inflammatory	inflammatory	JJ
cord-262445-54ng7m92	473	40	or	or	CC
cord-262445-54ng7m92	473	41	autoimmunity	autoimmunity	NN
cord-262445-54ng7m92	473	42	environment	environment	NN
cord-262445-54ng7m92	473	43	.	.	.
cord-262445-54ng7m92	474	1	Duchenne	Duchenne	NNP
cord-262445-54ng7m92	474	2	Muscular	Muscular	NNP
cord-262445-54ng7m92	474	3	Dystrophy	Dystrophy	NNP
cord-262445-54ng7m92	474	4	(	(	-LRB-
cord-262445-54ng7m92	474	5	DMD	DMD	NNP
cord-262445-54ng7m92	474	6	)	)	-RRB-
cord-262445-54ng7m92	474	7	,	,	,
cord-262445-54ng7m92	474	8	caused	cause	VBN
cord-262445-54ng7m92	474	9	by	by	IN
cord-262445-54ng7m92	474	10	genetic	genetic	JJ
cord-262445-54ng7m92	474	11	mutations	mutation	NNS
cord-262445-54ng7m92	474	12	leading	lead	VBG
cord-262445-54ng7m92	474	13	to	to	IN
cord-262445-54ng7m92	474	14	the	the	DT
cord-262445-54ng7m92	474	15	absence	absence	NN
cord-262445-54ng7m92	474	16	of	of	IN
cord-262445-54ng7m92	474	17	dystrophin	dystrophin	NN
cord-262445-54ng7m92	474	18	,	,	,
cord-262445-54ng7m92	474	19	is	be	VBZ
cord-262445-54ng7m92	474	20	the	the	DT
cord-262445-54ng7m92	474	21	most	most	RBS
cord-262445-54ng7m92	474	22	common	common	JJ
cord-262445-54ng7m92	474	23	and	and	CC
cord-262445-54ng7m92	474	24	severe	severe	JJ
cord-262445-54ng7m92	474	25	muscular	muscular	JJ
cord-262445-54ng7m92	474	26	dystrophy	dystrophy	NN
cord-262445-54ng7m92	474	27	,	,	,
cord-262445-54ng7m92	474	28	characterised	characterise	VBN
cord-262445-54ng7m92	474	29	by	by	IN
cord-262445-54ng7m92	474	30	progressive	progressive	JJ
cord-262445-54ng7m92	474	31	muscle	muscle	NN
cord-262445-54ng7m92	474	32	degeneration	degeneration	NN
cord-262445-54ng7m92	474	33	leading	lead	VBG
cord-262445-54ng7m92	474	34	to	to	IN
cord-262445-54ng7m92	474	35	premature	premature	JJ
cord-262445-54ng7m92	474	36	death	death	NN
cord-262445-54ng7m92	474	37	by	by	IN
cord-262445-54ng7m92	474	38	the	the	DT
cord-262445-54ng7m92	474	39	age	age	NN
cord-262445-54ng7m92	474	40	of	of	IN
cord-262445-54ng7m92	474	41	20	20	CD
cord-262445-54ng7m92	474	42	-	-	SYM
cord-262445-54ng7m92	474	43	30	30	CD
cord-262445-54ng7m92	474	44	years	year	NNS
cord-262445-54ng7m92	474	45	old	old	JJ
cord-262445-54ng7m92	474	46	.	.	.
cord-262445-54ng7m92	475	1	In	in	IN
cord-262445-54ng7m92	475	2	DMD	DMD	NNP
cord-262445-54ng7m92	475	3	skeletal	skeletal	JJ
cord-262445-54ng7m92	475	4	muscle	muscle	NN
cord-262445-54ng7m92	475	5	,	,	,
cord-262445-54ng7m92	475	6	the	the	DT
cord-262445-54ng7m92	475	7	repeated	repeated	JJ
cord-262445-54ng7m92	475	8	episodes	episode	NNS
cord-262445-54ng7m92	475	9	of	of	IN
cord-262445-54ng7m92	475	10	muscle	muscle	NN
cord-262445-54ng7m92	475	11	fiber	fiber	NN
cord-262445-54ng7m92	475	12	injury	injury	NN
cord-262445-54ng7m92	475	13	and	and	CC
cord-262445-54ng7m92	475	14	necrosis	necrosis	NN
cord-262445-54ng7m92	475	15	,	,	,
cord-262445-54ng7m92	475	16	and	and	CC
cord-262445-54ng7m92	475	17	the	the	DT
cord-262445-54ng7m92	475	18	subsequent	subsequent	JJ
cord-262445-54ng7m92	475	19	fibrosis	fibrosis	NN
cord-262445-54ng7m92	475	20	are	be	VBP
cord-262445-54ng7m92	475	21	driven	drive	VBN
cord-262445-54ng7m92	475	22	to	to	IN
cord-262445-54ng7m92	475	23	a	a	DT
cord-262445-54ng7m92	475	24	large	large	JJ
cord-262445-54ng7m92	475	25	extent	extent	NN
cord-262445-54ng7m92	475	26	by	by	IN
cord-262445-54ng7m92	475	27	complex	complex	JJ
cord-262445-54ng7m92	475	28	interactions	interaction	NNS
cord-262445-54ng7m92	475	29	between	between	IN
cord-262445-54ng7m92	475	30	dystrophin	dystrophin	NN
cord-262445-54ng7m92	475	31	deficiency	deficiency	NN
cord-262445-54ng7m92	475	32	and	and	CC
cord-262445-54ng7m92	475	33	the	the	DT
cord-262445-54ng7m92	475	34	host	host	NN
cord-262445-54ng7m92	475	35	immune	immune	JJ
cord-262445-54ng7m92	475	36	response	response	NN
cord-262445-54ng7m92	475	37	.	.	.
cord-262445-54ng7m92	476	1	This	this	DT
cord-262445-54ng7m92	476	2	has	have	VBZ
cord-262445-54ng7m92	476	3	been	be	VBN
cord-262445-54ng7m92	476	4	demonstrated	demonstrate	VBN
cord-262445-54ng7m92	476	5	by	by	IN
cord-262445-54ng7m92	476	6	removing	remove	VBG
cord-262445-54ng7m92	476	7	macrophages	macrophage	NNS
cord-262445-54ng7m92	476	8	and	and	CC
cord-262445-54ng7m92	476	9	other	other	JJ
cord-262445-54ng7m92	476	10	inflammatory	inflammatory	JJ
cord-262445-54ng7m92	476	11	cell	cell	NN
cord-262445-54ng7m92	476	12	types	type	NNS
cord-262445-54ng7m92	476	13	in	in	IN
cord-262445-54ng7m92	476	14	the	the	DT
cord-262445-54ng7m92	476	15	mdx	mdx	NNP
cord-262445-54ng7m92	476	16	mouse	mouse	NN
cord-262445-54ng7m92	476	17	model	model	NN
cord-262445-54ng7m92	476	18	of	of	IN
cord-262445-54ng7m92	476	19	DMD	DMD	NNP
cord-262445-54ng7m92	476	20	as	as	RB
cord-262445-54ng7m92	476	21	well	well	RB
cord-262445-54ng7m92	476	22	as	as	IN
cord-262445-54ng7m92	476	23	through	through	IN
cord-262445-54ng7m92	476	24	the	the	DT
cord-262445-54ng7m92	476	25	inhibition	inhibition	NN
cord-262445-54ng7m92	476	26	of	of	IN
cord-262445-54ng7m92	476	27	key	key	JJ
cord-262445-54ng7m92	476	28	mediators	mediator	NNS
cord-262445-54ng7m92	476	29	of	of	IN
cord-262445-54ng7m92	476	30	inflammation	inflammation	NN
cord-262445-54ng7m92	476	31	.	.	.
cord-262445-54ng7m92	477	1	The	the	DT
cord-262445-54ng7m92	477	2	approved	approve	VBN
cord-262445-54ng7m92	477	3	therapies	therapy	NNS
cord-262445-54ng7m92	477	4	,	,	,
cord-262445-54ng7m92	477	5	based	base	VBN
cord-262445-54ng7m92	477	6	on	on	IN
cord-262445-54ng7m92	477	7	corticosteroids	corticosteroid	NNS
cord-262445-54ng7m92	477	8	,	,	,
cord-262445-54ng7m92	477	9	support	support	VBP
cord-262445-54ng7m92	477	10	the	the	DT
cord-262445-54ng7m92	477	11	evidence	evidence	NN
cord-262445-54ng7m92	477	12	of	of	IN
cord-262445-54ng7m92	477	13	the	the	DT
cord-262445-54ng7m92	477	14	major	major	JJ
cord-262445-54ng7m92	477	15	role	role	NN
cord-262445-54ng7m92	477	16	of	of	IN
cord-262445-54ng7m92	477	17	inflammation	inflammation	NN
cord-262445-54ng7m92	477	18	in	in	IN
cord-262445-54ng7m92	477	19	this	this	DT
cord-262445-54ng7m92	477	20	disease	disease	NN
cord-262445-54ng7m92	477	21	.	.	.
cord-262445-54ng7m92	478	1	Nevertheless	nevertheless	RB
cord-262445-54ng7m92	478	2	,	,	,
cord-262445-54ng7m92	478	3	due	due	IN
cord-262445-54ng7m92	478	4	to	to	IN
cord-262445-54ng7m92	478	5	their	-PRON-	PRP$
cord-262445-54ng7m92	478	6	limitations	limitation	NNS
cord-262445-54ng7m92	478	7	in	in	IN
cord-262445-54ng7m92	478	8	terms	term	NNS
cord-262445-54ng7m92	478	9	of	of	IN
cord-262445-54ng7m92	478	10	efficacy	efficacy	NN
cord-262445-54ng7m92	478	11	and	and	CC
cord-262445-54ng7m92	478	12	adverse	adverse	JJ
cord-262445-54ng7m92	478	13	events	event	NNS
cord-262445-54ng7m92	478	14	,	,	,
cord-262445-54ng7m92	478	15	they	-PRON-	PRP
cord-262445-54ng7m92	478	16	encourage	encourage	VBP
cord-262445-54ng7m92	478	17	us	-PRON-	PRP
cord-262445-54ng7m92	478	18	to	to	TO
cord-262445-54ng7m92	478	19	find	find	VB
cord-262445-54ng7m92	478	20	alternative	alternative	JJ
cord-262445-54ng7m92	478	21	approaches	approach	NNS
cord-262445-54ng7m92	478	22	derived	derive	VBN
cord-262445-54ng7m92	478	23	from	from	IN
cord-262445-54ng7m92	478	24	the	the	DT
cord-262445-54ng7m92	478	25	identification	identification	NN
cord-262445-54ng7m92	478	26	of	of	IN
cord-262445-54ng7m92	478	27	novel	novel	JJ
cord-262445-54ng7m92	478	28	suitable	suitable	JJ
cord-262445-54ng7m92	478	29	therapeutic	therapeutic	JJ
cord-262445-54ng7m92	478	30	targets	target	NNS
cord-262445-54ng7m92	478	31	.	.	.
cord-262445-54ng7m92	479	1	To	to	IN
cord-262445-54ng7m92	479	2	this	this	DT
cord-262445-54ng7m92	479	3	end	end	NN
cord-262445-54ng7m92	479	4	we	-PRON-	PRP
cord-262445-54ng7m92	479	5	have	have	VBP
cord-262445-54ng7m92	479	6	been	be	VBN
cord-262445-54ng7m92	479	7	investigating	investigate	VBG
cord-262445-54ng7m92	479	8	,	,	,
cord-262445-54ng7m92	479	9	in	in	IN
cord-262445-54ng7m92	479	10	DMD	DMD	NNP
cord-262445-54ng7m92	479	11	progression	progression	NN
cord-262445-54ng7m92	479	12	,	,	,
cord-262445-54ng7m92	479	13	the	the	DT
cord-262445-54ng7m92	479	14	pathway	pathway	NN
cord-262445-54ng7m92	479	15	of	of	IN
cord-262445-54ng7m92	479	16	the	the	DT
cord-262445-54ng7m92	479	17	sphingolipid	sphingolipid	NN
cord-262445-54ng7m92	479	18	metabolising	metabolise	VBG
cord-262445-54ng7m92	479	19	enzyme	enzyme	NN
cord-262445-54ng7m92	479	20	,	,	,
cord-262445-54ng7m92	479	21	acid	acid	NNP
cord-262445-54ng7m92	479	22	sphingomyelinase	sphingomyelinase	NN
cord-262445-54ng7m92	479	23	(	(	-LRB-
cord-262445-54ng7m92	479	24	A	A	NNP
cord-262445-54ng7m92	479	25	-	-	HYPH
cord-262445-54ng7m92	479	26	SMase	SMase	NNP
cord-262445-54ng7m92	479	27	)	)	-RRB-
cord-262445-54ng7m92	479	28	,	,	,
cord-262445-54ng7m92	479	29	which	which	WDT
cord-262445-54ng7m92	479	30	has	have	VBZ
cord-262445-54ng7m92	479	31	recently	recently	RB
cord-262445-54ng7m92	479	32	been	be	VBN
cord-262445-54ng7m92	479	33	demonstrated	demonstrate	VBN
cord-262445-54ng7m92	479	34	to	to	TO
cord-262445-54ng7m92	479	35	be	be	VB
cord-262445-54ng7m92	479	36	involved	involve	VBN
cord-262445-54ng7m92	479	37	in	in	IN
cord-262445-54ng7m92	479	38	inflammatory	inflammatory	JJ
cord-262445-54ng7m92	479	39	related	related	JJ
cord-262445-54ng7m92	479	40	disorders	disorder	NNS
cord-262445-54ng7m92	479	41	.	.	.
cord-262445-54ng7m92	480	1	Our	-PRON-	PRP$
cord-262445-54ng7m92	480	2	results	result	NNS
cord-262445-54ng7m92	480	3	in	in	IN
cord-262445-54ng7m92	480	4	mdx	mdx	NNP
cord-262445-54ng7m92	480	5	mice	mice	NN
cord-262445-54ng7m92	480	6	muscles	muscle	NNS
cord-262445-54ng7m92	480	7	revealed	reveal	VBD
cord-262445-54ng7m92	480	8	an	an	DT
cord-262445-54ng7m92	480	9	upregulation	upregulation	NN
cord-262445-54ng7m92	480	10	of	of	IN
cord-262445-54ng7m92	480	11	A	a	DT
cord-262445-54ng7m92	480	12	-	-	HYPH
cord-262445-54ng7m92	480	13	SMase	smase	JJ
cord-262445-54ng7m92	480	14	expression	expression	NN
cord-262445-54ng7m92	480	15	and	and	CC
cord-262445-54ng7m92	480	16	activity	activity	NN
cord-262445-54ng7m92	480	17	strongly	strongly	RB
cord-262445-54ng7m92	480	18	connected	connect	VBN
cord-262445-54ng7m92	480	19	to	to	IN
cord-262445-54ng7m92	480	20	inflammation	inflammation	NN
cord-262445-54ng7m92	480	21	.	.	.
cord-262445-54ng7m92	481	1	Muscle	muscle	NN
cord-262445-54ng7m92	481	2	regeneration	regeneration	NN
cord-262445-54ng7m92	481	3	in	in	IN
cord-262445-54ng7m92	481	4	DMD	DMD	NNP
cord-262445-54ng7m92	481	5	can	can	MD
cord-262445-54ng7m92	481	6	be	be	VB
cord-262445-54ng7m92	481	7	impaired	impair	VBN
cord-262445-54ng7m92	481	8	due	due	IN
cord-262445-54ng7m92	481	9	to	to	IN
cord-262445-54ng7m92	481	10	an	an	DT
cord-262445-54ng7m92	481	11	imbalance	imbalance	NN
cord-262445-54ng7m92	481	12	in	in	IN
cord-262445-54ng7m92	481	13	M1	M1	NNP
cord-262445-54ng7m92	481	14	(	(	-LRB-
cord-262445-54ng7m92	481	15	pro	pro	JJ
cord-262445-54ng7m92	481	16	-	-	JJ
cord-262445-54ng7m92	481	17	inflammatory	inflammatory	JJ
cord-262445-54ng7m92	481	18	)	)	-RRB-
cord-262445-54ng7m92	481	19	and	and	CC
cord-262445-54ng7m92	481	20	M2	M2	NNP
cord-262445-54ng7m92	481	21	(	(	-LRB-
cord-262445-54ng7m92	481	22	anti	anti	JJ
cord-262445-54ng7m92	481	23	-	-	JJ
cord-262445-54ng7m92	481	24	inflammatory	inflammatory	JJ
cord-262445-54ng7m92	481	25	)	)	-RRB-
cord-262445-54ng7m92	481	26	macrophage	macrophage	NN
cord-262445-54ng7m92	481	27	phenotypes	phenotype	NNS
cord-262445-54ng7m92	481	28	.	.	.
cord-262445-54ng7m92	482	1	Our	-PRON-	PRP$
cord-262445-54ng7m92	482	2	studies	study	NNS
cord-262445-54ng7m92	482	3	in	in	IN
cord-262445-54ng7m92	482	4	A	a	DT
cord-262445-54ng7m92	482	5	-	-	HYPH
cord-262445-54ng7m92	482	6	SMase	smase	NN
cord-262445-54ng7m92	482	7	-/mice	-/mice	NN
cord-262445-54ng7m92	482	8	,	,	,
cord-262445-54ng7m92	482	9	to	to	TO
cord-262445-54ng7m92	482	10	investigate	investigate	VB
cord-262445-54ng7m92	482	11	deeper	deep	JJR
cord-262445-54ng7m92	482	12	the	the	DT
cord-262445-54ng7m92	482	13	role	role	NN
cord-262445-54ng7m92	482	14	of	of	IN
cord-262445-54ng7m92	482	15	A	a	DT
cord-262445-54ng7m92	482	16	-	-	HYPH
cord-262445-54ng7m92	482	17	SMase	SMase	NNP
cord-262445-54ng7m92	482	18	show	show	VBP
cord-262445-54ng7m92	482	19	that	that	IN
cord-262445-54ng7m92	482	20	this	this	DT
cord-262445-54ng7m92	482	21	enzyme	enzyme	NN
cord-262445-54ng7m92	482	22	is	be	VBZ
cord-262445-54ng7m92	482	23	fundamental	fundamental	JJ
cord-262445-54ng7m92	482	24	for	for	IN
cord-262445-54ng7m92	482	25	M1	M1	NNP
cord-262445-54ng7m92	482	26	macrophage	macrophage	NN
cord-262445-54ng7m92	482	27	polarization	polarization	NN
cord-262445-54ng7m92	482	28	and	and	CC
cord-262445-54ng7m92	482	29	that	that	IN
cord-262445-54ng7m92	482	30	following	follow	VBG
cord-262445-54ng7m92	482	31	injury	injury	NN
cord-262445-54ng7m92	482	32	in	in	IN
cord-262445-54ng7m92	482	33	A	a	DT
cord-262445-54ng7m92	482	34	-	-	HYPH
cord-262445-54ng7m92	482	35	SMase	smase	NN
cord-262445-54ng7m92	483	1	-/mice	-/mice	.
cord-262445-54ng7m92	484	1	there	there	EX
cord-262445-54ng7m92	484	2	is	be	VBZ
cord-262445-54ng7m92	484	3	a	a	DT
cord-262445-54ng7m92	484	4	short	short	JJ
cord-262445-54ng7m92	484	5	M1	M1	NNP
cord-262445-54ng7m92	484	6	macrophage	macrophage	NN
cord-262445-54ng7m92	484	7	phenotype	phenotype	NN
cord-262445-54ng7m92	484	8	retention	retention	NN
cord-262445-54ng7m92	484	9	phase	phase	NN
cord-262445-54ng7m92	484	10	and	and	CC
cord-262445-54ng7m92	484	11	a	a	DT
cord-262445-54ng7m92	484	12	corresponding	corresponding	JJ
cord-262445-54ng7m92	484	13	enhanced	enhance	VBN
cord-262445-54ng7m92	484	14	M2	m2	JJ
cord-262445-54ng7m92	484	15	macrophage	macrophage	NN
cord-262445-54ng7m92	484	16	phenotype	phenotype	NN
cord-262445-54ng7m92	484	17	function	function	NN
cord-262445-54ng7m92	484	18	.	.	.
cord-262445-54ng7m92	485	1	As	as	IN
cord-262445-54ng7m92	485	2	a	a	DT
cord-262445-54ng7m92	485	3	proof	proof	NN
cord-262445-54ng7m92	485	4	-	-	HYPH
cord-262445-54ng7m92	485	5	of	of	IN
cord-262445-54ng7m92	485	6	-	-	HYPH
cord-262445-54ng7m92	485	7	concept	concept	NN
cord-262445-54ng7m92	485	8	of	of	IN
cord-262445-54ng7m92	485	9	pharmacological	pharmacological	JJ
cord-262445-54ng7m92	485	10	inhibition	inhibition	NN
cord-262445-54ng7m92	485	11	of	of	IN
cord-262445-54ng7m92	485	12	A	A	NNP
cord-262445-54ng7m92	485	13	-	-	HYPH
cord-262445-54ng7m92	485	14	SMase	SMase	NNP
cord-262445-54ng7m92	485	15	as	as	IN
cord-262445-54ng7m92	485	16	a	a	DT
cord-262445-54ng7m92	485	17	potential	potential	JJ
cord-262445-54ng7m92	485	18	strategy	strategy	NN
cord-262445-54ng7m92	485	19	for	for	IN
cord-262445-54ng7m92	485	20	DMD	DMD	NNP
cord-262445-54ng7m92	485	21	we	-PRON-	PRP
cord-262445-54ng7m92	485	22	analysed	analyse	VBD
cord-262445-54ng7m92	485	23	A	a	DT
cord-262445-54ng7m92	485	24	-	-	HYPH
cord-262445-54ng7m92	485	25	SMase	smase	JJ
cord-262445-54ng7m92	485	26	expression	expression	NN
cord-262445-54ng7m92	485	27	or	or	CC
cord-262445-54ng7m92	485	28	activity	activity	NN
cord-262445-54ng7m92	485	29	in	in	IN
cord-262445-54ng7m92	485	30	mice	mouse	NNS
cord-262445-54ng7m92	485	31	treated	treat	VBN
cord-262445-54ng7m92	485	32	with	with	IN
cord-262445-54ng7m92	485	33	drugs	drug	NNS
cord-262445-54ng7m92	485	34	already	already	RB
cord-262445-54ng7m92	485	35	proven	prove	VBN
cord-262445-54ng7m92	485	36	to	to	TO
cord-262445-54ng7m92	485	37	be	be	VB
cord-262445-54ng7m92	485	38	beneficial	beneficial	JJ
cord-262445-54ng7m92	485	39	for	for	IN
cord-262445-54ng7m92	485	40	mdx	mdx	NNP
cord-262445-54ng7m92	485	41	mice	mouse	NNS
cord-262445-54ng7m92	485	42	:	:	:
cord-262445-54ng7m92	485	43	the	the	DT
cord-262445-54ng7m92	485	44	anti	anti	JJ
cord-262445-54ng7m92	485	45	-	-	JJ
cord-262445-54ng7m92	485	46	inflammatory	inflammatory	JJ
cord-262445-54ng7m92	485	47	drugs	drug	NNS
cord-262445-54ng7m92	485	48	naproxen	naproxen	NNP
cord-262445-54ng7m92	485	49	/	/	SYM
cord-262445-54ng7m92	485	50	naproxcinod	naproxcinod	NNP
cord-262445-54ng7m92	485	51	and	and	CC
cord-262445-54ng7m92	485	52	amitriptyline	amitriptyline	NNP
cord-262445-54ng7m92	485	53	,	,	,
cord-262445-54ng7m92	485	54	a	a	DT
cord-262445-54ng7m92	485	55	functional	functional	JJ
cord-262445-54ng7m92	485	56	inhibitor	inhibitor	NN
cord-262445-54ng7m92	485	57	of	of	IN
cord-262445-54ng7m92	485	58	A	A	NNP
cord-262445-54ng7m92	485	59	-	-	HYPH
cord-262445-54ng7m92	485	60	SMase	SMase	NNP
cord-262445-54ng7m92	485	61	(	(	-LRB-
cord-262445-54ng7m92	485	62	FIASMA	FIASMA	NNP
cord-262445-54ng7m92	485	63	)	)	-RRB-
cord-262445-54ng7m92	485	64	.	.	.
cord-262445-54ng7m92	486	1	We	-PRON-	PRP
cord-262445-54ng7m92	486	2	found	find	VBD
cord-262445-54ng7m92	486	3	that	that	IN
cord-262445-54ng7m92	486	4	the	the	DT
cord-262445-54ng7m92	486	5	anti	anti	JJ
cord-262445-54ng7m92	486	6	-	-	JJ
cord-262445-54ng7m92	486	7	inflammatory	inflammatory	JJ
cord-262445-54ng7m92	486	8	drugs	drug	NNS
cord-262445-54ng7m92	486	9	inhibited	inhibit	VBN
cord-262445-54ng7m92	486	10	expression	expression	NN
cord-262445-54ng7m92	486	11	and	and	CC
cord-262445-54ng7m92	486	12	activity	activity	NN
cord-262445-54ng7m92	486	13	of	of	IN
cord-262445-54ng7m92	486	14	A	a	NN
cord-262445-54ng7m92	486	15	-	-	HYPH
cord-262445-54ng7m92	486	16	SMase	SMase	NNP
cord-262445-54ng7m92	486	17	while	while	IN
cord-262445-54ng7m92	486	18	amitriptyline	amitriptyline	NN
cord-262445-54ng7m92	486	19	reduced	reduce	VBD
cord-262445-54ng7m92	486	20	the	the	DT
cord-262445-54ng7m92	486	21	enzyme	enzyme	NN
cord-262445-54ng7m92	486	22	activity	activity	NN
cord-262445-54ng7m92	486	23	.	.	.
cord-262445-54ng7m92	487	1	Our	-PRON-	PRP$
cord-262445-54ng7m92	487	2	next	next	JJ
cord-262445-54ng7m92	487	3	step	step	NN
cord-262445-54ng7m92	487	4	is	be	VBZ
cord-262445-54ng7m92	487	5	to	to	TO
cord-262445-54ng7m92	487	6	test	test	VB
cord-262445-54ng7m92	487	7	the	the	DT
cord-262445-54ng7m92	487	8	in	in	IN
cord-262445-54ng7m92	487	9	vivo	vivo	NN
cord-262445-54ng7m92	487	10	efficacy	efficacy	NN
cord-262445-54ng7m92	487	11	of	of	IN
cord-262445-54ng7m92	487	12	other	other	JJ
cord-262445-54ng7m92	487	13	FIASMAs	fiasma	NNS
cord-262445-54ng7m92	487	14	(	(	-LRB-
cord-262445-54ng7m92	487	15	i.e.	i.e.	FW
cord-262445-54ng7m92	487	16	the	the	DT
cord-262445-54ng7m92	487	17	SSRI	SSRI	NNP
cord-262445-54ng7m92	487	18	fluoxetine	fluoxetine	NN
cord-262445-54ng7m92	487	19	and	and	CC
cord-262445-54ng7m92	487	20	sertraline	sertraline	NN
cord-262445-54ng7m92	487	21	)	)	-RRB-
cord-262445-54ng7m92	487	22	with	with	IN
cord-262445-54ng7m92	487	23	a	a	DT
cord-262445-54ng7m92	487	24	better	well	JJR
cord-262445-54ng7m92	487	25	safety	safety	NN
cord-262445-54ng7m92	487	26	profile	profile	NN
cord-262445-54ng7m92	487	27	than	than	IN
cord-262445-54ng7m92	487	28	amitriptyline	amitriptyline	NN
cord-262445-54ng7m92	487	29	.	.	.
cord-262445-54ng7m92	488	1	The	the	DT
cord-262445-54ng7m92	488	2	advantage	advantage	NN
cord-262445-54ng7m92	488	3	of	of	IN
cord-262445-54ng7m92	488	4	this	this	DT
cord-262445-54ng7m92	488	5	strategy	strategy	NN
cord-262445-54ng7m92	488	6	is	be	VBZ
cord-262445-54ng7m92	488	7	manifold	manifold	JJ
cord-262445-54ng7m92	488	8	:	:	:
cord-262445-54ng7m92	488	9	i.	i.	NN
cord-262445-54ng7m92	488	10	these	these	DT
cord-262445-54ng7m92	488	11	drugs	drug	NNS
cord-262445-54ng7m92	488	12	are	be	VBP
cord-262445-54ng7m92	488	13	already	already	RB
cord-262445-54ng7m92	488	14	approved	approve	VBN
cord-262445-54ng7m92	488	15	by	by	IN
cord-262445-54ng7m92	488	16	the	the	DT
cord-262445-54ng7m92	488	17	EMA	EMA	NNP
cord-262445-54ng7m92	488	18	and	and	CC
cord-262445-54ng7m92	488	19	the	the	DT
cord-262445-54ng7m92	488	20	FDA	FDA	NNP
cord-262445-54ng7m92	488	21	,	,	,
cord-262445-54ng7m92	488	22	confirmed	confirm	VBD
cord-262445-54ng7m92	488	23	minimally	minimally	RB
cord-262445-54ng7m92	488	24	toxic	toxic	JJ
cord-262445-54ng7m92	488	25	and	and	CC
cord-262445-54ng7m92	488	26	potentially	potentially	RB
cord-262445-54ng7m92	488	27	rapidly	rapidly	RB
cord-262445-54ng7m92	488	28	available	available	JJ
cord-262445-54ng7m92	488	29	for	for	IN
cord-262445-54ng7m92	488	30	clinical	clinical	JJ
cord-262445-54ng7m92	488	31	use	use	NN
cord-262445-54ng7m92	488	32	as	as	IN
cord-262445-54ng7m92	488	33	repositioned	reposition	VBN
cord-262445-54ng7m92	488	34	drugs	drug	NNS
cord-262445-54ng7m92	488	35	;	;	:
cord-262445-54ng7m92	488	36	ii	ii	NN
cord-262445-54ng7m92	488	37	.	.	.
cord-262445-54ng7m92	489	1	they	-PRON-	PRP
cord-262445-54ng7m92	489	2	can	can	MD
cord-262445-54ng7m92	489	3	also	also	RB
cord-262445-54ng7m92	489	4	alleviate	alleviate	VB
cord-262445-54ng7m92	489	5	the	the	DT
cord-262445-54ng7m92	489	6	depressive	depressive	JJ
cord-262445-54ng7m92	489	7	symptoms	symptom	NNS
cord-262445-54ng7m92	489	8	often	often	RB
cord-262445-54ng7m92	489	9	displayed	display	VBN
cord-262445-54ng7m92	489	10	by	by	IN
cord-262445-54ng7m92	489	11	patients	patient	NNS
cord-262445-54ng7m92	489	12	;	;	:
cord-262445-54ng7m92	489	13	iii	iii	NNP
cord-262445-54ng7m92	489	14	.	.	.
cord-262445-54ng7m92	490	1	they	-PRON-	PRP
cord-262445-54ng7m92	490	2	can	can	MD
cord-262445-54ng7m92	490	3	synergise	synergise	VB
cord-262445-54ng7m92	490	4	with	with	IN
cord-262445-54ng7m92	490	5	the	the	DT
cord-262445-54ng7m92	490	6	gene	gene	NN
cord-262445-54ng7m92	490	7	-	-	HYPH
cord-262445-54ng7m92	490	8	based	base	VBN
cord-262445-54ng7m92	490	9	therapies	therapy	NNS
cord-262445-54ng7m92	490	10	currently	currently	RB
cord-262445-54ng7m92	490	11	under	under	IN
cord-262445-54ng7m92	490	12	investigation	investigation	NN
cord-262445-54ng7m92	490	13	.	.	.
cord-262445-54ng7m92	491	1	The	the	DT
cord-262445-54ng7m92	491	2	skeletal	skeletal	JJ
cord-262445-54ng7m92	491	3	muscle	muscle	NN
cord-262445-54ng7m92	491	4	tissue	tissue	NN
cord-262445-54ng7m92	491	5	exhibits	exhibit	VBZ
cord-262445-54ng7m92	491	6	regenerative	regenerative	JJ
cord-262445-54ng7m92	491	7	capabilities	capability	NNS
cord-262445-54ng7m92	491	8	related	relate	VBN
cord-262445-54ng7m92	491	9	to	to	IN
cord-262445-54ng7m92	491	10	damage	damage	NN
cord-262445-54ng7m92	491	11	extension	extension	NN
cord-262445-54ng7m92	491	12	.	.	.
cord-262445-54ng7m92	492	1	In	in	IN
cord-262445-54ng7m92	492	2	fact	fact	NN
cord-262445-54ng7m92	492	3	,	,	,
cord-262445-54ng7m92	492	4	it	-PRON-	PRP
cord-262445-54ng7m92	492	5	is	be	VBZ
cord-262445-54ng7m92	492	6	able	able	JJ
cord-262445-54ng7m92	492	7	to	to	TO
cord-262445-54ng7m92	492	8	restore	restore	VB
cord-262445-54ng7m92	492	9	limited	limited	JJ
cord-262445-54ng7m92	492	10	injuries	injury	NNS
cord-262445-54ng7m92	492	11	while	while	IN
cord-262445-54ng7m92	492	12	,	,	,
cord-262445-54ng7m92	492	13	following	follow	VBG
cord-262445-54ng7m92	492	14	volumetric	volumetric	JJ
cord-262445-54ng7m92	492	15	muscle	muscle	NN
cord-262445-54ng7m92	492	16	loss	loss	NN
cord-262445-54ng7m92	492	17	(	(	-LRB-
cord-262445-54ng7m92	492	18	VML	VML	NNP
cord-262445-54ng7m92	492	19	)	)	-RRB-
cord-262445-54ng7m92	492	20	,	,	,
cord-262445-54ng7m92	492	21	the	the	DT
cord-262445-54ng7m92	492	22	recovery	recovery	NN
cord-262445-54ng7m92	492	23	is	be	VBZ
cord-262445-54ng7m92	492	24	poor	poor	JJ
cord-262445-54ng7m92	492	25	accompanied	accompany	VBN
cord-262445-54ng7m92	492	26	by	by	IN
cord-262445-54ng7m92	492	27	scar	scar	NN
cord-262445-54ng7m92	492	28	formation	formation	NN
cord-262445-54ng7m92	492	29	and	and	CC
cord-262445-54ng7m92	492	30	functional	functional	JJ
cord-262445-54ng7m92	492	31	detriment	detriment	NN
cord-262445-54ng7m92	492	32	.	.	.
cord-262445-54ng7m92	493	1	This	this	DT
cord-262445-54ng7m92	493	2	condition	condition	NN
cord-262445-54ng7m92	493	3	negatively	negatively	RB
cord-262445-54ng7m92	493	4	affects	affect	VBZ
cord-262445-54ng7m92	493	5	the	the	DT
cord-262445-54ng7m92	493	6	quality	quality	NN
cord-262445-54ng7m92	493	7	of	of	IN
cord-262445-54ng7m92	493	8	life	life	NN
cord-262445-54ng7m92	493	9	of	of	IN
cord-262445-54ng7m92	493	10	patients	patient	NNS
cord-262445-54ng7m92	493	11	affected	affect	VBN
cord-262445-54ng7m92	493	12	by	by	IN
cord-262445-54ng7m92	493	13	VML	VML	NNP
cord-262445-54ng7m92	493	14	,	,	,
cord-262445-54ng7m92	493	15	making	make	VBG
cord-262445-54ng7m92	493	16	necessary	necessary	JJ
cord-262445-54ng7m92	493	17	reconstructive	reconstructive	JJ
cord-262445-54ng7m92	493	18	therapeutic	therapeutic	JJ
cord-262445-54ng7m92	493	19	approaches	approach	NNS
cord-262445-54ng7m92	493	20	.	.	.
cord-262445-54ng7m92	494	1	Even	even	RB
cord-262445-54ng7m92	494	2	if	if	IN
cord-262445-54ng7m92	494	3	surgical	surgical	JJ
cord-262445-54ng7m92	494	4	autologous	autologous	JJ
cord-262445-54ng7m92	494	5	transplantation	transplantation	NN
cord-262445-54ng7m92	494	6	is	be	VBZ
cord-262445-54ng7m92	494	7	a	a	DT
cord-262445-54ng7m92	494	8	standardized	standardized	JJ
cord-262445-54ng7m92	494	9	procedure	procedure	NN
cord-262445-54ng7m92	494	10	,	,	,
cord-262445-54ng7m92	494	11	the	the	DT
cord-262445-54ng7m92	494	12	outcomes	outcome	NNS
cord-262445-54ng7m92	494	13	are	be	VBP
cord-262445-54ng7m92	494	14	often	often	RB
cord-262445-54ng7m92	494	15	unsatisfactory	unsatisfactory	JJ
cord-262445-54ng7m92	494	16	.	.	.
cord-262445-54ng7m92	495	1	Hence	hence	RB
cord-262445-54ng7m92	495	2	,	,	,
cord-262445-54ng7m92	495	3	the	the	DT
cord-262445-54ng7m92	495	4	pressing	press	VBG
cord-262445-54ng7m92	495	5	need	need	NN
cord-262445-54ng7m92	495	6	to	to	TO
cord-262445-54ng7m92	495	7	develop	develop	VB
cord-262445-54ng7m92	495	8	engineered	engineer	VBN
cord-262445-54ng7m92	495	9	artificial	artificial	JJ
cord-262445-54ng7m92	495	10	tissues	tissue	NNS
cord-262445-54ng7m92	495	11	to	to	TO
cord-262445-54ng7m92	495	12	replace	replace	VB
cord-262445-54ng7m92	495	13	wasted	waste	VBN
cord-262445-54ng7m92	495	14	muscle	muscle	NN
cord-262445-54ng7m92	495	15	.	.	.
cord-262445-54ng7m92	496	1	Tissue	tissue	NN
cord-262445-54ng7m92	496	2	engineering	engineering	NN
cord-262445-54ng7m92	496	3	(	(	-LRB-
cord-262445-54ng7m92	496	4	TE	TE	NNP
cord-262445-54ng7m92	496	5	)	)	-RRB-
cord-262445-54ng7m92	496	6	,	,	,
cord-262445-54ng7m92	496	7	exploiting	exploit	VBG
cord-262445-54ng7m92	496	8	stem	stem	NN
cord-262445-54ng7m92	496	9	cells	cell	NNS
cord-262445-54ng7m92	496	10	embedded	embed	VBN
cord-262445-54ng7m92	496	11	in	in	IN
cord-262445-54ng7m92	496	12	biomimetic	biomimetic	JJ
cord-262445-54ng7m92	496	13	scaffolds	scaffold	NNS
cord-262445-54ng7m92	496	14	,	,	,
cord-262445-54ng7m92	496	15	aims	aim	VBZ
cord-262445-54ng7m92	496	16	to	to	TO
cord-262445-54ng7m92	496	17	mimic	mimic	VB
cord-262445-54ng7m92	496	18	organogenesis	organogenesi	NNS
cord-262445-54ng7m92	496	19	by	by	IN
cord-262445-54ng7m92	496	20	building	build	VBG
cord-262445-54ng7m92	496	21	artificial	artificial	JJ
cord-262445-54ng7m92	496	22	tissues	tissue	NNS
cord-262445-54ng7m92	496	23	to	to	TO
cord-262445-54ng7m92	496	24	replace	replace	VB
cord-262445-54ng7m92	496	25	the	the	DT
cord-262445-54ng7m92	496	26	damaged	damage	VBN
cord-262445-54ng7m92	496	27	ones	one	NNS
cord-262445-54ng7m92	496	28	.	.	.
cord-262445-54ng7m92	497	1	Skeletal	skeletal	JJ
cord-262445-54ng7m92	497	2	muscle	muscle	NN
cord-262445-54ng7m92	497	3	TE	TE	NNP
cord-262445-54ng7m92	497	4	is	be	VBZ
cord-262445-54ng7m92	497	5	an	an	DT
cord-262445-54ng7m92	497	6	up	up	JJ
cord-262445-54ng7m92	497	7	-	-	HYPH
cord-262445-54ng7m92	497	8	and	and	CC
cord-262445-54ng7m92	497	9	-	-	HYPH
cord-262445-54ng7m92	497	10	coming	come	VBG
cord-262445-54ng7m92	497	11	biotechnology	biotechnology	NN
cord-262445-54ng7m92	497	12	with	with	IN
cord-262445-54ng7m92	497	13	great	great	JJ
cord-262445-54ng7m92	497	14	potential	potential	NN
cord-262445-54ng7m92	497	15	for	for	IN
cord-262445-54ng7m92	497	16	muscle	muscle	NN
cord-262445-54ng7m92	497	17	repair	repair	NN
cord-262445-54ng7m92	497	18	,	,	,
cord-262445-54ng7m92	497	19	but	but	CC
cord-262445-54ng7m92	497	20	no	no	DT
cord-262445-54ng7m92	497	21	conclusive	conclusive	JJ
cord-262445-54ng7m92	497	22	strategy	strategy	NN
cord-262445-54ng7m92	497	23	has	have	VBZ
cord-262445-54ng7m92	497	24	been	be	VBN
cord-262445-54ng7m92	497	25	conceived	conceive	VBN
cord-262445-54ng7m92	497	26	yet	yet	RB
cord-262445-54ng7m92	497	27	.	.	.
cord-262445-54ng7m92	498	1	Reconstructing	reconstruct	VBG
cord-262445-54ng7m92	498	2	the	the	DT
cord-262445-54ng7m92	498	3	skeletal	skeletal	JJ
cord-262445-54ng7m92	498	4	muscle	muscle	NN
cord-262445-54ng7m92	498	5	architecture	architecture	NN
cord-262445-54ng7m92	498	6	and	and	CC
cord-262445-54ng7m92	498	7	function	function	NN
cord-262445-54ng7m92	498	8	is	be	VBZ
cord-262445-54ng7m92	498	9	still	still	RB
cord-262445-54ng7m92	498	10	a	a	DT
cord-262445-54ng7m92	498	11	challenge	challenge	NN
cord-262445-54ng7m92	498	12	requiring	require	VBG
cord-262445-54ng7m92	498	13	the	the	DT
cord-262445-54ng7m92	498	14	parallel	parallel	JJ
cord-262445-54ng7m92	498	15	alignment	alignment	NN
cord-262445-54ng7m92	498	16	of	of	IN
cord-262445-54ng7m92	498	17	myofibrils	myofibril	NNS
cord-262445-54ng7m92	498	18	arranged	arrange	VBN
cord-262445-54ng7m92	498	19	into	into	IN
cord-262445-54ng7m92	498	20	organized	organized	JJ
cord-262445-54ng7m92	498	21	sarcomeres	sarcomere	NNS
cord-262445-54ng7m92	498	22	.	.	.
cord-262445-54ng7m92	499	1	Recently	recently	RB
cord-262445-54ng7m92	499	2	we	-PRON-	PRP
cord-262445-54ng7m92	499	3	demonstrated	demonstrate	VBD
cord-262445-54ng7m92	499	4	the	the	DT
cord-262445-54ng7m92	499	5	great	great	JJ
cord-262445-54ng7m92	499	6	potential	potential	NN
cord-262445-54ng7m92	499	7	of	of	IN
cord-262445-54ng7m92	499	8	a	a	DT
cord-262445-54ng7m92	499	9	hybrid	hybrid	JJ
cord-262445-54ng7m92	499	10	biomimetic	biomimetic	JJ
cord-262445-54ng7m92	499	11	matrix	matrix	NN
cord-262445-54ng7m92	499	12	,	,	,
cord-262445-54ng7m92	499	13	namely	namely	RB
cord-262445-54ng7m92	499	14	PEG	PEG	NNP
cord-262445-54ng7m92	499	15	-	-	HYPH
cord-262445-54ng7m92	499	16	Fibrinogen	Fibrinogen	NNP
cord-262445-54ng7m92	499	17	,	,	,
cord-262445-54ng7m92	499	18	for	for	IN
cord-262445-54ng7m92	499	19	enhancing	enhance	VBG
cord-262445-54ng7m92	499	20	the	the	DT
cord-262445-54ng7m92	499	21	engraftment	engraftment	NN
cord-262445-54ng7m92	499	22	of	of	IN
cord-262445-54ng7m92	499	23	myogenic	myogenic	NNP
cord-262445-54ng7m92	499	24	cell	cell	NN
cord-262445-54ng7m92	499	25	progenitors	progenitor	NNS
cord-262445-54ng7m92	499	26	by	by	IN
cord-262445-54ng7m92	499	27	providing	provide	VBG
cord-262445-54ng7m92	499	28	a	a	DT
cord-262445-54ng7m92	499	29	suitable	suitable	JJ
cord-262445-54ng7m92	499	30	3D	3d	JJ
cord-262445-54ng7m92	499	31	environment	environment	NN
cord-262445-54ng7m92	499	32	for	for	IN
cord-262445-54ng7m92	499	33	mouse	mouse	NN
cord-262445-54ng7m92	499	34	muscle	muscle	NN
cord-262445-54ng7m92	499	35	reconstruction	reconstruction	NN
cord-262445-54ng7m92	499	36	.	.	.
cord-262445-54ng7m92	500	1	Starting	start	VBG
cord-262445-54ng7m92	500	2	from	from	IN
cord-262445-54ng7m92	500	3	these	these	DT
cord-262445-54ng7m92	500	4	observations	observation	NNS
cord-262445-54ng7m92	500	5	,	,	,
cord-262445-54ng7m92	500	6	we	-PRON-	PRP
cord-262445-54ng7m92	500	7	chose	choose	VBD
cord-262445-54ng7m92	500	8	to	to	TO
cord-262445-54ng7m92	500	9	use	use	VB
cord-262445-54ng7m92	500	10	a	a	DT
cord-262445-54ng7m92	500	11	novel	novel	JJ
cord-262445-54ng7m92	500	12	approach	approach	NN
cord-262445-54ng7m92	500	13	for	for	IN
cord-262445-54ng7m92	500	14	the	the	DT
cord-262445-54ng7m92	500	15	regeneration	regeneration	NN
cord-262445-54ng7m92	500	16	and/or	and/or	CC
cord-262445-54ng7m92	500	17	reconstruction	reconstruction	NN
cord-262445-54ng7m92	500	18	of	of	IN
cord-262445-54ng7m92	500	19	skeletal	skeletal	JJ
cord-262445-54ng7m92	500	20	muscle	muscle	NN
cord-262445-54ng7m92	500	21	tissue	tissue	NN
cord-262445-54ng7m92	500	22	combining	combine	VBG
cord-262445-54ng7m92	500	23	muscle	muscle	NN
cord-262445-54ng7m92	500	24	progenitors	progenitor	NNS
cord-262445-54ng7m92	500	25	with	with	IN
cord-262445-54ng7m92	500	26	3D	3D	NNP
cord-262445-54ng7m92	500	27	bio	bio	NNP
cord-262445-54ng7m92	500	28	-	-	HYPH
cord-262445-54ng7m92	500	29	printing	print	VBG
cord-262445-54ng7m92	500	30	technology	technology	NN
cord-262445-54ng7m92	500	31	to	to	TO
cord-262445-54ng7m92	500	32	guarantee	guarantee	VB
cord-262445-54ng7m92	500	33	a	a	DT
cord-262445-54ng7m92	500	34	functional	functional	JJ
cord-262445-54ng7m92	500	35	architecture	architecture	NN
cord-262445-54ng7m92	500	36	.	.	.
cord-262445-54ng7m92	501	1	In	in	IN
cord-262445-54ng7m92	501	2	particular	particular	JJ
cord-262445-54ng7m92	501	3	we	-PRON-	PRP
cord-262445-54ng7m92	501	4	have	have	VBP
cord-262445-54ng7m92	501	5	developed	develop	VBN
cord-262445-54ng7m92	501	6	a	a	DT
cord-262445-54ng7m92	501	7	microfluidic	microfluidic	JJ
cord-262445-54ng7m92	501	8	wet	wet	RB
cord-262445-54ng7m92	501	9	-	-	HYPH
cord-262445-54ng7m92	501	10	spinning	spin	VBG
cord-262445-54ng7m92	501	11	system	system	NN
cord-262445-54ng7m92	501	12	that	that	WDT
cord-262445-54ng7m92	501	13	allows	allow	VBZ
cord-262445-54ng7m92	501	14	to	to	TO
cord-262445-54ng7m92	501	15	fabricate	fabricate	VB
cord-262445-54ng7m92	501	16	rapidly	rapidly	RB
cord-262445-54ng7m92	501	17	macroscopic	macroscopic	JJ
cord-262445-54ng7m92	501	18	yarns	yarn	NNS
cord-262445-54ng7m92	501	19	of	of	IN
cord-262445-54ng7m92	501	20	cell	cell	NN
cord-262445-54ng7m92	501	21	-	-	HYPH
cord-262445-54ng7m92	501	22	laden	laden	JJ
cord-262445-54ng7m92	501	23	hydrogel	hydrogel	NN
cord-262445-54ng7m92	501	24	microfibers	microfiber	NNS
cord-262445-54ng7m92	501	25	that	that	WDT
cord-262445-54ng7m92	501	26	closely	closely	RB
cord-262445-54ng7m92	501	27	mimic	mimic	VBP
cord-262445-54ng7m92	501	28	the	the	DT
cord-262445-54ng7m92	501	29	structure	structure	NN
cord-262445-54ng7m92	501	30	of	of	IN
cord-262445-54ng7m92	501	31	skeletal	skeletal	JJ
cord-262445-54ng7m92	501	32	muscle	muscle	NN
cord-262445-54ng7m92	501	33	tissue	tissue	NN
cord-262445-54ng7m92	501	34	.	.	.
cord-262445-54ng7m92	502	1	In	in	IN
cord-262445-54ng7m92	502	2	vitro	vitro	FW
cord-262445-54ng7m92	502	3	and	and	CC
cord-262445-54ng7m92	502	4	in	in	IN
cord-262445-54ng7m92	502	5	vivo	vivo	NN
cord-262445-54ng7m92	502	6	characterization	characterization	NN
cord-262445-54ng7m92	502	7	of	of	IN
cord-262445-54ng7m92	502	8	cell	cell	NN
cord-262445-54ng7m92	502	9	-	-	HYPH
cord-262445-54ng7m92	502	10	laden	laden	JJ
cord-262445-54ng7m92	502	11	constructs	construct	NNS
cord-262445-54ng7m92	502	12	showed	show	VBD
cord-262445-54ng7m92	502	13	enhanced	enhance	VBN
cord-262445-54ng7m92	502	14	myogenesis	myogenesis	NN
cord-262445-54ng7m92	502	15	and	and	CC
cord-262445-54ng7m92	502	16	positive	positive	JJ
cord-262445-54ng7m92	502	17	myo	myo	NN
cord-262445-54ng7m92	502	18	-	-	HYPH
cord-262445-54ng7m92	502	19	structure	structure	NN
cord-262445-54ng7m92	502	20	alignment	alignment	NN
cord-262445-54ng7m92	502	21	.	.	.
cord-262445-54ng7m92	503	1	Oxidative	oxidative	JJ
cord-262445-54ng7m92	503	2	stress	stress	NN
cord-262445-54ng7m92	503	3	and	and	CC
cord-262445-54ng7m92	503	4	mitochondrial	mitochondrial	JJ
cord-262445-54ng7m92	503	5	dysfunction	dysfunction	NN
cord-262445-54ng7m92	503	6	play	play	VBP
cord-262445-54ng7m92	503	7	a	a	DT
cord-262445-54ng7m92	503	8	crucial	crucial	JJ
cord-262445-54ng7m92	503	9	role	role	NN
cord-262445-54ng7m92	503	10	in	in	IN
cord-262445-54ng7m92	503	11	the	the	DT
cord-262445-54ng7m92	503	12	pathophysiology	pathophysiology	NN
cord-262445-54ng7m92	503	13	of	of	IN
cord-262445-54ng7m92	503	14	muscular	muscular	JJ
cord-262445-54ng7m92	503	15	dystrophies	dystrophy	NNS
cord-262445-54ng7m92	503	16	.	.	.
cord-262445-54ng7m92	504	1	We	-PRON-	PRP
cord-262445-54ng7m92	504	2	recently	recently	RB
cord-262445-54ng7m92	504	3	reported	report	VBD
cord-262445-54ng7m92	504	4	that	that	IN
cord-262445-54ng7m92	504	5	the	the	DT
cord-262445-54ng7m92	504	6	reactive	reactive	JJ
cord-262445-54ng7m92	504	7	oxygen	oxygen	NN
cord-262445-54ng7m92	504	8	species	specie	NNS
cord-262445-54ng7m92	504	9	(	(	-LRB-
cord-262445-54ng7m92	504	10	ROS	ROS	NNP
cord-262445-54ng7m92	504	11	)	)	-RRB-
cord-262445-54ng7m92	504	12	produced	produce	VBN
cord-262445-54ng7m92	504	13	by	by	IN
cord-262445-54ng7m92	504	14	the	the	DT
cord-262445-54ng7m92	504	15	mitochondrial	mitochondrial	JJ
cord-262445-54ng7m92	504	16	enzyme	enzyme	NN
cord-262445-54ng7m92	504	17	monoamine	monoamine	NN
cord-262445-54ng7m92	504	18	oxidase	oxidase	NN
cord-262445-54ng7m92	504	19	B	B	NNP
cord-262445-54ng7m92	504	20	(	(	-LRB-
cord-262445-54ng7m92	504	21	MAO	MAO	NNP
cord-262445-54ng7m92	504	22	-	-	HYPH
cord-262445-54ng7m92	504	23	B	B	NNP
cord-262445-54ng7m92	504	24	)	)	-RRB-
cord-262445-54ng7m92	504	25	are	be	VBP
cord-262445-54ng7m92	504	26	causally	causally	RB
cord-262445-54ng7m92	504	27	involved	involve	VBN
cord-262445-54ng7m92	504	28	in	in	IN
cord-262445-54ng7m92	504	29	Duchenne	Duchenne	NNP
cord-262445-54ng7m92	504	30	pathophysiology	pathophysiology	NN
cord-262445-54ng7m92	504	31	,	,	,
cord-262445-54ng7m92	504	32	as	as	IN
cord-262445-54ng7m92	504	33	demonstrated	demonstrate	VBN
cord-262445-54ng7m92	504	34	by	by	IN
cord-262445-54ng7m92	504	35	the	the	DT
cord-262445-54ng7m92	504	36	results	result	NNS
cord-262445-54ng7m92	504	37	we	-PRON-	PRP
cord-262445-54ng7m92	504	38	obtained	obtain	VBD
cord-262445-54ng7m92	504	39	by	by	IN
cord-262445-54ng7m92	504	40	treating	treat	VBG
cord-262445-54ng7m92	504	41	mdx	mdx	NNP
cord-262445-54ng7m92	504	42	mice	mouse	NNS
cord-262445-54ng7m92	504	43	with	with	IN
cord-262445-54ng7m92	504	44	the	the	DT
cord-262445-54ng7m92	504	45	MAO	MAO	NNP
cord-262445-54ng7m92	504	46	-	-	HYPH
cord-262445-54ng7m92	504	47	B	B	NNP
cord-262445-54ng7m92	504	48	specific	specific	JJ
cord-262445-54ng7m92	504	49	inhibitor	inhibitor	NN
cord-262445-54ng7m92	504	50	safinamide	safinamide	NN
cord-262445-54ng7m92	504	51	.	.	.
cord-262445-54ng7m92	505	1	We	-PRON-	PRP
cord-262445-54ng7m92	505	2	now	now	RB
cord-262445-54ng7m92	505	3	show	show	VBP
cord-262445-54ng7m92	505	4	that	that	IN
cord-262445-54ng7m92	505	5	a	a	DT
cord-262445-54ng7m92	505	6	novel	novel	JJ
cord-262445-54ng7m92	505	7	drug	drug	NN
cord-262445-54ng7m92	505	8	,	,	,
cord-262445-54ng7m92	505	9	PXS	PXS	NNP
cord-262445-54ng7m92	505	10	,	,	,
cord-262445-54ng7m92	505	11	designed	design	VBN
cord-262445-54ng7m92	505	12	to	to	TO
cord-262445-54ng7m92	505	13	inhibit	inhibit	VB
cord-262445-54ng7m92	505	14	both	both	DT
cord-262445-54ng7m92	505	15	MAO	MAO	NNP
cord-262445-54ng7m92	505	16	-	-	HYPH
cord-262445-54ng7m92	505	17	B	B	NNP
cord-262445-54ng7m92	505	18	and	and	CC
cord-262445-54ng7m92	505	19	the	the	DT
cord-262445-54ng7m92	505	20	amino	amino	NN
cord-262445-54ng7m92	505	21	oxidase	oxidase	NN
cord-262445-54ng7m92	505	22	VAP-1	VAP-1	NNP
cord-262445-54ng7m92	505	23	(	(	-LRB-
cord-262445-54ng7m92	505	24	a	a	DT
cord-262445-54ng7m92	505	25	glycoprotein	glycoprotein	NN
cord-262445-54ng7m92	505	26	found	find	VBN
cord-262445-54ng7m92	505	27	on	on	IN
cord-262445-54ng7m92	505	28	the	the	DT
cord-262445-54ng7m92	505	29	plasma	plasma	NN
cord-262445-54ng7m92	505	30	membrane	membrane	NN
cord-262445-54ng7m92	505	31	of	of	IN
cord-262445-54ng7m92	505	32	several	several	JJ
cord-262445-54ng7m92	505	33	cell	cell	NN
cord-262445-54ng7m92	505	34	types	type	NNS
cord-262445-54ng7m92	505	35	)	)	-RRB-
cord-262445-54ng7m92	505	36	,	,	,
cord-262445-54ng7m92	505	37	provides	provide	VBZ
cord-262445-54ng7m92	505	38	comparable	comparable	JJ
cord-262445-54ng7m92	505	39	or	or	CC
cord-262445-54ng7m92	505	40	superior	superior	JJ
cord-262445-54ng7m92	505	41	effect	effect	NN
cord-262445-54ng7m92	505	42	to	to	IN
cord-262445-54ng7m92	505	43	safinamide	safinamide	NN
cord-262445-54ng7m92	505	44	,	,	,
cord-262445-54ng7m92	505	45	but	but	CC
cord-262445-54ng7m92	505	46	at	at	IN
cord-262445-54ng7m92	505	47	a	a	DT
cord-262445-54ng7m92	505	48	much	much	RB
cord-262445-54ng7m92	505	49	lower	low	JJR
cord-262445-54ng7m92	505	50	dosage	dosage	NN
cord-262445-54ng7m92	505	51	.	.	.
cord-262445-54ng7m92	506	1	Specifically	specifically	RB
cord-262445-54ng7m92	506	2	,	,	,
cord-262445-54ng7m92	506	3	we	-PRON-	PRP
cord-262445-54ng7m92	506	4	found	find	VBD
cord-262445-54ng7m92	506	5	that	that	IN
cord-262445-54ng7m92	506	6	a	a	DT
cord-262445-54ng7m92	506	7	30-day	30-day	CD
cord-262445-54ng7m92	506	8	treatment	treatment	NN
cord-262445-54ng7m92	506	9	with	with	IN
cord-262445-54ng7m92	506	10	PXS	PXS	NNP
cord-262445-54ng7m92	506	11	in	in	IN
cord-262445-54ng7m92	506	12	one	one	CD
cord-262445-54ng7m92	506	13	-	-	HYPH
cord-262445-54ng7m92	506	14	and	and	CC
cord-262445-54ng7m92	506	15	three	three	CD
cord-262445-54ng7m92	506	16	-	-	HYPH
cord-262445-54ng7m92	506	17	month	month	NN
cord-262445-54ng7m92	506	18	-	-	HYPH
cord-262445-54ng7m92	506	19	old	old	JJ
cord-262445-54ng7m92	506	20	mdx	mdx	NNP
cord-262445-54ng7m92	506	21	mice	mouse	NNS
cord-262445-54ng7m92	506	22	greatly	greatly	RB
cord-262445-54ng7m92	506	23	reduced	reduce	VBN
cord-262445-54ng7m92	506	24	fibrosis	fibrosis	NN
cord-262445-54ng7m92	506	25	,	,	,
cord-262445-54ng7m92	506	26	inflammation	inflammation	NN
cord-262445-54ng7m92	506	27	and	and	CC
cord-262445-54ng7m92	506	28	oxidative	oxidative	JJ
cord-262445-54ng7m92	506	29	stress	stress	NN
cord-262445-54ng7m92	506	30	in	in	IN
cord-262445-54ng7m92	506	31	both	both	DT
cord-262445-54ng7m92	506	32	diaphragm	diaphragm	NN
cord-262445-54ng7m92	506	33	and	and	CC
cord-262445-54ng7m92	506	34	tibialis	tibialis	NNP
cord-262445-54ng7m92	506	35	anterior	anterior	NNP
cord-262445-54ng7m92	506	36	,	,	,
cord-262445-54ng7m92	506	37	while	while	IN
cord-262445-54ng7m92	506	38	also	also	RB
cord-262445-54ng7m92	506	39	improving	improve	VBG
cord-262445-54ng7m92	506	40	muscle	muscle	NN
cord-262445-54ng7m92	506	41	contractile	contractile	JJ
cord-262445-54ng7m92	506	42	properties	property	NNS
cord-262445-54ng7m92	506	43	in	in	IN
cord-262445-54ng7m92	506	44	diaphragm	diaphragm	NN
cord-262445-54ng7m92	506	45	and	and	CC
cord-262445-54ng7m92	506	46	gastrocnemius	gastrocnemius	NN
cord-262445-54ng7m92	506	47	.	.	.
cord-262445-54ng7m92	507	1	Importantly	importantly	RB
cord-262445-54ng7m92	507	2	,	,	,
cord-262445-54ng7m92	507	3	we	-PRON-	PRP
cord-262445-54ng7m92	507	4	have	have	VBP
cord-262445-54ng7m92	507	5	also	also	RB
cord-262445-54ng7m92	507	6	obtained	obtain	VBN
cord-262445-54ng7m92	507	7	preliminary	preliminary	JJ
cord-262445-54ng7m92	507	8	indications	indication	NNS
cord-262445-54ng7m92	507	9	that	that	IN
cord-262445-54ng7m92	507	10	a	a	DT
cord-262445-54ng7m92	507	11	90-day	90-day	CD
cord-262445-54ng7m92	507	12	treatment	treatment	NN
cord-262445-54ng7m92	507	13	with	with	IN
cord-262445-54ng7m92	507	14	PXS	PXS	NNP
cord-262445-54ng7m92	507	15	led	lead	VBD
cord-262445-54ng7m92	507	16	to	to	IN
cord-262445-54ng7m92	507	17	a	a	DT
cord-262445-54ng7m92	507	18	decrease	decrease	NN
cord-262445-54ng7m92	507	19	in	in	IN
cord-262445-54ng7m92	507	20	heart	heart	NN
cord-262445-54ng7m92	507	21	fibrosis	fibrosis	NN
cord-262445-54ng7m92	507	22	in	in	IN
cord-262445-54ng7m92	507	23	ninemonth	ninemonth	JJ
cord-262445-54ng7m92	507	24	-	-	HYPH
cord-262445-54ng7m92	507	25	old	old	JJ
cord-262445-54ng7m92	507	26	animals	animal	NNS
cord-262445-54ng7m92	507	27	.	.	.
cord-262445-54ng7m92	508	1	Considering	consider	VBG
cord-262445-54ng7m92	508	2	that	that	IN
cord-262445-54ng7m92	508	3	MAO	MAO	NNP
cord-262445-54ng7m92	508	4	-	-	HYPH
cord-262445-54ng7m92	508	5	B	B	NNP
cord-262445-54ng7m92	508	6	inhibitors	inhibitor	NNS
cord-262445-54ng7m92	508	7	have	have	VBP
cord-262445-54ng7m92	508	8	been	be	VBN
cord-262445-54ng7m92	508	9	in	in	IN
cord-262445-54ng7m92	508	10	clinical	clinical	JJ
cord-262445-54ng7m92	508	11	use	use	NN
cord-262445-54ng7m92	508	12	for	for	IN
cord-262445-54ng7m92	508	13	many	many	JJ
cord-262445-54ng7m92	508	14	years	year	NNS
cord-262445-54ng7m92	508	15	and	and	CC
cord-262445-54ng7m92	508	16	that	that	IN
cord-262445-54ng7m92	508	17	PXS	PXS	NNP
cord-262445-54ng7m92	508	18	has	have	VBZ
cord-262445-54ng7m92	508	19	already	already	RB
cord-262445-54ng7m92	508	20	passed	pass	VBN
cord-262445-54ng7m92	508	21	all	all	DT
cord-262445-54ng7m92	508	22	toxicity	toxicity	NN
cord-262445-54ng7m92	508	23	tests	test	NNS
cord-262445-54ng7m92	508	24	in	in	IN
cord-262445-54ng7m92	508	25	several	several	JJ
cord-262445-54ng7m92	508	26	animal	animal	NN
cord-262445-54ng7m92	508	27	models	model	NNS
cord-262445-54ng7m92	508	28	,	,	,
cord-262445-54ng7m92	508	29	our	-PRON-	PRP$
cord-262445-54ng7m92	508	30	findings	finding	NNS
cord-262445-54ng7m92	508	31	indicate	indicate	VBP
cord-262445-54ng7m92	508	32	that	that	IN
cord-262445-54ng7m92	508	33	PXS	PXS	NNP
cord-262445-54ng7m92	508	34	could	could	MD
cord-262445-54ng7m92	508	35	be	be	VB
cord-262445-54ng7m92	508	36	a	a	DT
cord-262445-54ng7m92	508	37	promising	promising	JJ
cord-262445-54ng7m92	508	38	candidate	candidate	NN
cord-262445-54ng7m92	508	39	for	for	IN
cord-262445-54ng7m92	508	40	the	the	DT
cord-262445-54ng7m92	508	41	treatment	treatment	NN
cord-262445-54ng7m92	508	42	of	of	IN
cord-262445-54ng7m92	508	43	DMD	DMD	NNP
cord-262445-54ng7m92	508	44	.	.	.
cord-262445-54ng7m92	509	1	Lurbinectedin	Lurbinectedin	NNP
cord-262445-54ng7m92	509	2	(	(	-LRB-
cord-262445-54ng7m92	509	3	PM01183	PM01183	NNP
cord-262445-54ng7m92	509	4	,	,	,
cord-262445-54ng7m92	509	5	PM	PM	NNP
cord-262445-54ng7m92	509	6	)	)	-RRB-
cord-262445-54ng7m92	509	7	is	be	VBZ
cord-262445-54ng7m92	509	8	a	a	DT
cord-262445-54ng7m92	509	9	synthetic	synthetic	JJ
cord-262445-54ng7m92	509	10	alkaloid	alkaloid	NN
cord-262445-54ng7m92	509	11	derivate	derivate	NN
cord-262445-54ng7m92	509	12	of	of	IN
cord-262445-54ng7m92	509	13	trabectedin	trabectedin	NNP
cord-262445-54ng7m92	509	14	(	(	-LRB-
cord-262445-54ng7m92	509	15	ET743	ET743	NNP
cord-262445-54ng7m92	509	16	,	,	,
cord-262445-54ng7m92	509	17	ET	ET	NNP
cord-262445-54ng7m92	509	18	)	)	-RRB-
cord-262445-54ng7m92	509	19	,	,	,
cord-262445-54ng7m92	509	20	a	a	DT
cord-262445-54ng7m92	509	21	marine	marine	NN
cord-262445-54ng7m92	509	22	-	-	HYPH
cord-262445-54ng7m92	509	23	derived	derive	VBN
cord-262445-54ng7m92	509	24	anticancer	anticancer	JJ
cord-262445-54ng7m92	509	25	agent	agent	NN
cord-262445-54ng7m92	509	26	.	.	.
cord-262445-54ng7m92	510	1	PM	pm	NN
cord-262445-54ng7m92	510	2	is	be	VBZ
cord-262445-54ng7m92	510	3	a	a	DT
cord-262445-54ng7m92	510	4	DNA	dna	NN
cord-262445-54ng7m92	510	5	minor	minor	JJ
cord-262445-54ng7m92	510	6	groove	groove	NN
cord-262445-54ng7m92	510	7	covalent	covalent	JJ
cord-262445-54ng7m92	510	8	binder	binder	NN
cord-262445-54ng7m92	510	9	that	that	WDT
cord-262445-54ng7m92	510	10	has	have	VBZ
cord-262445-54ng7m92	510	11	been	be	VBN
cord-262445-54ng7m92	510	12	tested	test	VBN
cord-262445-54ng7m92	510	13	in	in	IN
cord-262445-54ng7m92	510	14	different	different	JJ
cord-262445-54ng7m92	510	15	Phase	phase	NN
cord-262445-54ng7m92	510	16	I	I	NNP
cord-262445-54ng7m92	510	17	-	-	HYPH
cord-262445-54ng7m92	510	18	III	iii	CD
cord-262445-54ng7m92	510	19	trials	trial	NNS
cord-262445-54ng7m92	510	20	.	.	.
cord-262445-54ng7m92	511	1	It	-PRON-	PRP
cord-262445-54ng7m92	511	2	affects	affect	VBZ
cord-262445-54ng7m92	511	3	tumor	tumor	NN
cord-262445-54ng7m92	511	4	microenvironment	microenvironment	NN
cord-262445-54ng7m92	511	5	by	by	IN
cord-262445-54ng7m92	511	6	limiting	limit	VBG
cord-262445-54ng7m92	511	7	the	the	DT
cord-262445-54ng7m92	511	8	production	production	NN
cord-262445-54ng7m92	511	9	of	of	IN
cord-262445-54ng7m92	511	10	inflammatory	inflammatory	JJ
cord-262445-54ng7m92	511	11	cytokines	cytokine	NNS
cord-262445-54ng7m92	511	12	.	.	.
cord-262445-54ng7m92	512	1	Some	some	DT
cord-262445-54ng7m92	512	2	of	of	IN
cord-262445-54ng7m92	512	3	these	these	DT
cord-262445-54ng7m92	512	4	cytokines	cytokine	NNS
cord-262445-54ng7m92	512	5	are	be	VBP
cord-262445-54ng7m92	512	6	elevated	elevate	VBN
cord-262445-54ng7m92	512	7	in	in	IN
cord-262445-54ng7m92	512	8	various	various	JJ
cord-262445-54ng7m92	512	9	cancers	cancer	NNS
cord-262445-54ng7m92	512	10	characterized	characterize	VBN
cord-262445-54ng7m92	512	11	by	by	IN
cord-262445-54ng7m92	512	12	rapid	rapid	JJ
cord-262445-54ng7m92	512	13	body	body	NN
cord-262445-54ng7m92	512	14	wasting	waste	VBG
cord-262445-54ng7m92	512	15	with	with	IN
cord-262445-54ng7m92	512	16	muscle	muscle	NN
cord-262445-54ng7m92	512	17	,	,	,
cord-262445-54ng7m92	512	18	fat	fat	JJ
cord-262445-54ng7m92	512	19	and	and	CC
cord-262445-54ng7m92	512	20	cardiac	cardiac	JJ
cord-262445-54ng7m92	512	21	tissue	tissue	NN
cord-262445-54ng7m92	512	22	depletion	depletion	NN
cord-262445-54ng7m92	512	23	(	(	-LRB-
cord-262445-54ng7m92	512	24	i.e.	i.e.	FW
cord-262445-54ng7m92	512	25	cachexia	cachexia	NN
cord-262445-54ng7m92	512	26	)	)	-RRB-
cord-262445-54ng7m92	512	27	.	.	.
cord-262445-54ng7m92	513	1	Differing	differ	VBG
cord-262445-54ng7m92	513	2	from	from	IN
cord-262445-54ng7m92	513	3	ET	ET	NNP
cord-262445-54ng7m92	513	4	,	,	,
cord-262445-54ng7m92	513	5	PM	PM	NNP
cord-262445-54ng7m92	513	6	displays	display	VBZ
cord-262445-54ng7m92	513	7	less	less	JJR
cord-262445-54ng7m92	513	8	liver	liver	NN
cord-262445-54ng7m92	513	9	toxicity	toxicity	NN
cord-262445-54ng7m92	513	10	,	,	,
cord-262445-54ng7m92	513	11	and	and	CC
cord-262445-54ng7m92	513	12	less	less	RBR
cord-262445-54ng7m92	513	13	endothelial	endothelial	JJ
cord-262445-54ng7m92	513	14	inflammation	inflammation	NN
cord-262445-54ng7m92	513	15	at	at	IN
cord-262445-54ng7m92	513	16	the	the	DT
cord-262445-54ng7m92	513	17	site	site	NN
cord-262445-54ng7m92	513	18	of	of	IN
cord-262445-54ng7m92	513	19	injection	injection	NN
cord-262445-54ng7m92	513	20	.	.	.
cord-262445-54ng7m92	514	1	Mice	mouse	NNS
cord-262445-54ng7m92	514	2	injected	inject	VBD
cord-262445-54ng7m92	514	3	with	with	IN
cord-262445-54ng7m92	514	4	murine	murine	JJ
cord-262445-54ng7m92	514	5	colon	colon	NN
cord-262445-54ng7m92	514	6	adenocarcinoma	adenocarcinoma	NN
cord-262445-54ng7m92	514	7	C26	C26	NNP
cord-262445-54ng7m92	514	8	cells	cell	NNS
cord-262445-54ng7m92	514	9	display	display	VBP
cord-262445-54ng7m92	514	10	cachexia	cachexia	NN
cord-262445-54ng7m92	514	11	,	,	,
cord-262445-54ng7m92	514	12	increased	increase	VBN
cord-262445-54ng7m92	514	13	circulating	circulate	VBG
cord-262445-54ng7m92	514	14	levels	level	NNS
cord-262445-54ng7m92	514	15	of	of	IN
cord-262445-54ng7m92	514	16	inflammatory	inflammatory	JJ
cord-262445-54ng7m92	514	17	cytokines	cytokine	NNS
cord-262445-54ng7m92	514	18	,	,	,
cord-262445-54ng7m92	514	19	acute	acute	JJ
cord-262445-54ng7m92	514	20	phase	phase	NN
cord-262445-54ng7m92	514	21	response	response	NN
cord-262445-54ng7m92	514	22	activation	activation	NN
cord-262445-54ng7m92	514	23	and	and	CC
cord-262445-54ng7m92	514	24	subsequent	subsequent	JJ
cord-262445-54ng7m92	514	25	splenomegaly	splenomegaly	NN
cord-262445-54ng7m92	514	26	.	.	.
cord-262445-54ng7m92	515	1	Thus	thus	RB
cord-262445-54ng7m92	515	2	,	,	,
cord-262445-54ng7m92	515	3	we	-PRON-	PRP
cord-262445-54ng7m92	515	4	tested	test	VBD
cord-262445-54ng7m92	515	5	whether	whether	IN
cord-262445-54ng7m92	515	6	PM	PM	NNP
cord-262445-54ng7m92	515	7	,	,	,
cord-262445-54ng7m92	515	8	at	at	IN
cord-262445-54ng7m92	515	9	doses	dose	NNS
cord-262445-54ng7m92	515	10	with	with	IN
cord-262445-54ng7m92	515	11	no	no	DT
cord-262445-54ng7m92	515	12	antitumoral	antitumoral	JJ
cord-262445-54ng7m92	515	13	activity	activity	NN
cord-262445-54ng7m92	515	14	on	on	IN
cord-262445-54ng7m92	515	15	C26	C26	NNP
cord-262445-54ng7m92	515	16	colon	colon	NN
cord-262445-54ng7m92	515	17	adenocarcinoma	adenocarcinoma	NN
cord-262445-54ng7m92	515	18	,	,	,
cord-262445-54ng7m92	515	19	has	have	VBZ
cord-262445-54ng7m92	515	20	any	any	DT
cord-262445-54ng7m92	515	21	beneficial	beneficial	JJ
cord-262445-54ng7m92	515	22	effects	effect	NNS
cord-262445-54ng7m92	515	23	in	in	IN
cord-262445-54ng7m92	515	24	mice	mouse	NNS
cord-262445-54ng7m92	515	25	against	against	IN
cord-262445-54ng7m92	515	26	C26-induced	C26-induced	NNP
cord-262445-54ng7m92	515	27	cachexia	cachexia	NN
cord-262445-54ng7m92	515	28	.	.	.
cord-262445-54ng7m92	516	1	10-weeks	10-weeks	CD
cord-262445-54ng7m92	517	1	old	old	JJ
cord-262445-54ng7m92	517	2	BALB	BALB	NNP
cord-262445-54ng7m92	517	3	/	/	SYM
cord-262445-54ng7m92	517	4	c	c	NN
cord-262445-54ng7m92	517	5	mice	mouse	NNS
cord-262445-54ng7m92	517	6	were	be	VBD
cord-262445-54ng7m92	517	7	injected	inject	VBN
cord-262445-54ng7m92	517	8	subcutaneously	subcutaneously	RB
cord-262445-54ng7m92	517	9	with	with	IN
cord-262445-54ng7m92	517	10	C26	C26	NNP
cord-262445-54ng7m92	517	11	cells	cell	NNS
cord-262445-54ng7m92	517	12	and	and	CC
cord-262445-54ng7m92	517	13	three	three	CD
cord-262445-54ng7m92	517	14	days	day	NNS
cord-262445-54ng7m92	517	15	later	later	RB
cord-262445-54ng7m92	517	16	randomized	randomize	VBN
cord-262445-54ng7m92	517	17	to	to	TO
cord-262445-54ng7m92	517	18	receive	receive	VB
cord-262445-54ng7m92	517	19	into	into	IN
cord-262445-54ng7m92	517	20	their	-PRON-	PRP$
cord-262445-54ng7m92	517	21	tail	tail	NN
cord-262445-54ng7m92	517	22	vein	vein	NN
cord-262445-54ng7m92	517	23	,	,	,
cord-262445-54ng7m92	517	24	three	three	CD
cord-262445-54ng7m92	517	25	times	time	NNS
cord-262445-54ng7m92	517	26	a	a	DT
cord-262445-54ng7m92	517	27	week	week	NN
cord-262445-54ng7m92	517	28	for	for	IN
cord-262445-54ng7m92	517	29	three	three	CD
cord-262445-54ng7m92	517	30	weeks	week	NNS
cord-262445-54ng7m92	518	1	0.07	0.07	CD
cord-262445-54ng7m92	518	2	mg	mg	NNP
cord-262445-54ng7m92	518	3	/	/	SYM
cord-262445-54ng7m92	518	4	kg	kg	NNP
cord-262445-54ng7m92	518	5	PM	PM	NNP
cord-262445-54ng7m92	518	6	(	(	-LRB-
cord-262445-54ng7m92	518	7	n	n	NN
cord-262445-54ng7m92	518	8	=	=	SYM
cord-262445-54ng7m92	518	9	8)	8)	NN
cord-262445-54ng7m92	518	10	or	or	CC
cord-262445-54ng7m92	518	11	vehicle	vehicle	NN
cord-262445-54ng7m92	518	12	(	(	-LRB-
cord-262445-54ng7m92	518	13	n	n	NN
cord-262445-54ng7m92	518	14	=	=	SYM
cord-262445-54ng7m92	518	15	8)	8)	NN
cord-262445-54ng7m92	518	16	.	.	.
cord-262445-54ng7m92	519	1	C26-carrying	c26-carrying	NN
cord-262445-54ng7m92	519	2	mice	mouse	NNS
cord-262445-54ng7m92	519	3	showed	show	VBD
cord-262445-54ng7m92	519	4	decreased	decreased	JJ
cord-262445-54ng7m92	519	5	body	body	NN
cord-262445-54ng7m92	519	6	weights	weight	NNS
cord-262445-54ng7m92	519	7	and	and	CC
cord-262445-54ng7m92	519	8	premature	premature	JJ
cord-262445-54ng7m92	519	9	death	death	NN
cord-262445-54ng7m92	519	10	.	.	.
cord-262445-54ng7m92	520	1	Strikingly	strikingly	RB
cord-262445-54ng7m92	520	2	,	,	,
cord-262445-54ng7m92	520	3	PM	PM	NNP
cord-262445-54ng7m92	520	4	was	be	VBD
cord-262445-54ng7m92	520	5	able	able	JJ
cord-262445-54ng7m92	520	6	to	to	TO
cord-262445-54ng7m92	520	7	extend	extend	VB
cord-262445-54ng7m92	520	8	the	the	DT
cord-262445-54ng7m92	520	9	lifespan	lifespan	NN
cord-262445-54ng7m92	520	10	of	of	IN
cord-262445-54ng7m92	520	11	C26-bearing	C26-bearing	NNP
cord-262445-54ng7m92	520	12	mice	mouse	NNS
cord-262445-54ng7m92	520	13	by	by	IN
cord-262445-54ng7m92	520	14	about	about	RB
cord-262445-54ng7m92	520	15	85	85	CD
cord-262445-54ng7m92	520	16	%	%	NN
cord-262445-54ng7m92	520	17	from	from	IN
cord-262445-54ng7m92	520	18	a	a	DT
cord-262445-54ng7m92	520	19	median	median	JJ
cord-262445-54ng7m92	520	20	survival	survival	NN
cord-262445-54ng7m92	520	21	time	time	NN
cord-262445-54ng7m92	520	22	of	of	IN
cord-262445-54ng7m92	520	23	20	20	CD
cord-262445-54ng7m92	520	24	days	day	NNS
cord-262445-54ng7m92	520	25	(	(	-LRB-
cord-262445-54ng7m92	520	26	range	range	VBP
cord-262445-54ng7m92	520	27	day	day	NNP
cord-262445-54ng7m92	520	28	10	10	CD
cord-262445-54ng7m92	520	29	-	-	SYM
cord-262445-54ng7m92	520	30	31	31	CD
cord-262445-54ng7m92	520	31	)	)	-RRB-
cord-262445-54ng7m92	520	32	to	to	IN
cord-262445-54ng7m92	520	33	a	a	DT
cord-262445-54ng7m92	520	34	median	median	JJ
cord-262445-54ng7m92	520	35	survival	survival	NN
cord-262445-54ng7m92	520	36	time	time	NN
cord-262445-54ng7m92	520	37	of	of	IN
cord-262445-54ng7m92	520	38	37	37	CD
cord-262445-54ng7m92	520	39	(	(	-LRB-
cord-262445-54ng7m92	520	40	range	range	NNP
cord-262445-54ng7m92	520	41	day	day	NNP
cord-262445-54ng7m92	520	42	14	14	CD
cord-262445-54ng7m92	520	43	-	-	SYM
cord-262445-54ng7m92	520	44	41	41	CD
cord-262445-54ng7m92	520	45	)	)	-RRB-
cord-262445-54ng7m92	520	46	.	.	.
cord-262445-54ng7m92	521	1	This	this	DT
cord-262445-54ng7m92	521	2	occurred	occur	VBD
cord-262445-54ng7m92	521	3	without	without	IN
cord-262445-54ng7m92	521	4	affecting	affect	VBG
cord-262445-54ng7m92	521	5	tumor	tumor	NN
cord-262445-54ng7m92	521	6	growth	growth	NN
cord-262445-54ng7m92	521	7	or	or	CC
cord-262445-54ng7m92	521	8	food	food	NN
cord-262445-54ng7m92	521	9	intake	intake	NN
cord-262445-54ng7m92	521	10	or	or	CC
cord-262445-54ng7m92	521	11	the	the	DT
cord-262445-54ng7m92	521	12	number	number	NN
cord-262445-54ng7m92	521	13	of	of	IN
cord-262445-54ng7m92	521	14	lung	lung	NN
cord-262445-54ng7m92	521	15	metastases	metastasis	NNS
cord-262445-54ng7m92	521	16	.	.	.
cord-262445-54ng7m92	522	1	Another	another	DT
cord-262445-54ng7m92	522	2	set	set	NN
cord-262445-54ng7m92	522	3	of	of	IN
cord-262445-54ng7m92	522	4	mice	mouse	NNS
cord-262445-54ng7m92	522	5	were	be	VBD
cord-262445-54ng7m92	522	6	sacrificed	sacrifice	VBN
cord-262445-54ng7m92	522	7	at	at	IN
cord-262445-54ng7m92	522	8	10	10	CD
cord-262445-54ng7m92	522	9	-	-	SYM
cord-262445-54ng7m92	522	10	13	13	CD
cord-262445-54ng7m92	522	11	days	day	NNS
cord-262445-54ng7m92	522	12	from	from	IN
cord-262445-54ng7m92	522	13	C26	C26	NNP
cord-262445-54ng7m92	522	14	implant	implant	JJ
cord-262445-54ng7m92	522	15	.	.	.
cord-262445-54ng7m92	523	1	PM	PM	NNP
cord-262445-54ng7m92	523	2	did	do	VBD
cord-262445-54ng7m92	523	3	not	not	RB
cord-262445-54ng7m92	523	4	grossly	grossly	RB
cord-262445-54ng7m92	523	5	protect	protect	VB
cord-262445-54ng7m92	523	6	multiple	multiple	JJ
cord-262445-54ng7m92	523	7	tissues	tissue	NNS
cord-262445-54ng7m92	523	8	(	(	-LRB-
cord-262445-54ng7m92	523	9	fat	fat	JJ
cord-262445-54ng7m92	523	10	,	,	,
cord-262445-54ng7m92	523	11	muscle	muscle	NN
cord-262445-54ng7m92	523	12	,	,	,
cord-262445-54ng7m92	523	13	heart	heart	NN
cord-262445-54ng7m92	523	14	)	)	-RRB-
cord-262445-54ng7m92	523	15	from	from	IN
cord-262445-54ng7m92	523	16	cachexia	cachexia	NN
cord-262445-54ng7m92	523	17	.	.	.
cord-262445-54ng7m92	524	1	Preliminary	preliminary	JJ
cord-262445-54ng7m92	524	2	data	datum	NNS
cord-262445-54ng7m92	524	3	showed	show	VBD
cord-262445-54ng7m92	524	4	that	that	IN
cord-262445-54ng7m92	524	5	C26-induced	C26-induced	NNP
cord-262445-54ng7m92	524	6	splenomegaly	splenomegaly	NN
cord-262445-54ng7m92	524	7	was	be	VBD
cord-262445-54ng7m92	524	8	inhibited	inhibit	VBN
cord-262445-54ng7m92	524	9	by	by	IN
cord-262445-54ng7m92	524	10	PM	PM	NNP
cord-262445-54ng7m92	524	11	administration	administration	NN
cord-262445-54ng7m92	524	12	as	as	RB
cord-262445-54ng7m92	524	13	long	long	RB
cord-262445-54ng7m92	524	14	as	as	IN
cord-262445-54ng7m92	524	15	PM	pm	NN
cord-262445-54ng7m92	524	16	treatment	treatment	NN
cord-262445-54ng7m92	524	17	lasted	last	VBD
cord-262445-54ng7m92	524	18	.	.	.
cord-262445-54ng7m92	525	1	In	in	IN
cord-262445-54ng7m92	525	2	C26-bearing	C26-bearing	NNP
cord-262445-54ng7m92	525	3	mice	mouse	NNS
cord-262445-54ng7m92	525	4	,	,	,
cord-262445-54ng7m92	525	5	this	this	DT
cord-262445-54ng7m92	525	6	effect	effect	NN
cord-262445-54ng7m92	525	7	exerted	exert	VBN
cord-262445-54ng7m92	525	8	by	by	IN
cord-262445-54ng7m92	525	9	PM	PM	NNP
cord-262445-54ng7m92	525	10	seems	seem	VBZ
cord-262445-54ng7m92	525	11	to	to	TO
cord-262445-54ng7m92	525	12	be	be	VB
cord-262445-54ng7m92	525	13	associated	associate	VBN
cord-262445-54ng7m92	525	14	also	also	RB
cord-262445-54ng7m92	525	15	to	to	IN
cord-262445-54ng7m92	525	16	restrained	restrain	VBN
cord-262445-54ng7m92	525	17	circulating	circulating	JJ
cord-262445-54ng7m92	525	18	levels	level	NNS
cord-262445-54ng7m92	525	19	of	of	IN
cord-262445-54ng7m92	525	20	M	M	NNP
cord-262445-54ng7m92	525	21	-	-	HYPH
cord-262445-54ng7m92	525	22	CSF	CSF	NNP
cord-262445-54ng7m92	525	23	,	,	,
cord-262445-54ng7m92	525	24	but	but	CC
cord-262445-54ng7m92	525	25	not	not	RB
cord-262445-54ng7m92	525	26	of	of	IN
cord-262445-54ng7m92	525	27	other	other	JJ
cord-262445-54ng7m92	525	28	inflammatory	inflammatory	JJ
cord-262445-54ng7m92	525	29	cytokines	cytokine	NNS
cord-262445-54ng7m92	525	30	(	(	-LRB-
cord-262445-54ng7m92	525	31	i.e.	i.e.	FW
cord-262445-54ng7m92	525	32	IL-6	IL-6	NNP
cord-262445-54ng7m92	525	33	,	,	,
cord-262445-54ng7m92	525	34	G	G	NNP
cord-262445-54ng7m92	525	35	-	-	HYPH
cord-262445-54ng7m92	525	36	CSF	CSF	NNP
cord-262445-54ng7m92	525	37	or	or	CC
cord-262445-54ng7m92	525	38	GM	GM	NNP
cord-262445-54ng7m92	525	39	-	-	HYPH
cord-262445-54ng7m92	525	40	CSF	CSF	NNP
cord-262445-54ng7m92	525	41	)	)	-RRB-
cord-262445-54ng7m92	525	42	.	.	.
cord-262445-54ng7m92	526	1	Further	further	RB
cord-262445-54ng7m92	526	2	studied	study	VBN
cord-262445-54ng7m92	526	3	are	be	VBP
cord-262445-54ng7m92	526	4	necessary	necessary	JJ
cord-262445-54ng7m92	526	5	to	to	TO
cord-262445-54ng7m92	526	6	correlate	correlate	VB
cord-262445-54ng7m92	526	7	the	the	DT
cord-262445-54ng7m92	526	8	improved	improved	JJ
cord-262445-54ng7m92	526	9	survival	survival	NN
cord-262445-54ng7m92	526	10	with	with	IN
cord-262445-54ng7m92	526	11	the	the	DT
cord-262445-54ng7m92	526	12	pharmacodynamic	pharmacodynamic	JJ
cord-262445-54ng7m92	526	13	effect	effect	NN
cord-262445-54ng7m92	526	14	observed	observe	VBD
cord-262445-54ng7m92	526	15	.	.	.
cord-262445-54ng7m92	527	1	Oxytocin	oxytocin	NN
cord-262445-54ng7m92	527	2	,	,	,
cord-262445-54ng7m92	527	3	classically	classically	RB
cord-262445-54ng7m92	527	4	known	know	VBN
cord-262445-54ng7m92	527	5	for	for	IN
cord-262445-54ng7m92	527	6	its	-PRON-	PRP$
cord-262445-54ng7m92	527	7	effects	effect	NNS
cord-262445-54ng7m92	527	8	on	on	IN
cord-262445-54ng7m92	527	9	uterus	uterus	NN
cord-262445-54ng7m92	527	10	,	,	,
cord-262445-54ng7m92	527	11	lactation	lactation	NN
cord-262445-54ng7m92	527	12	,	,	,
cord-262445-54ng7m92	527	13	CNS	CNS	NNP
cord-262445-54ng7m92	527	14	,	,	,
cord-262445-54ng7m92	527	15	is	be	VBZ
cord-262445-54ng7m92	527	16	also	also	RB
cord-262445-54ng7m92	527	17	a	a	DT
cord-262445-54ng7m92	527	18	powerful	powerful	JJ
cord-262445-54ng7m92	527	19	regulator	regulator	NN
cord-262445-54ng7m92	527	20	of	of	IN
cord-262445-54ng7m92	527	21	myogenic	myogenic	JJ
cord-262445-54ng7m92	527	22	differentiation	differentiation	NN
cord-262445-54ng7m92	527	23	and	and	CC
cord-262445-54ng7m92	527	24	muscular	muscular	JJ
cord-262445-54ng7m92	527	25	homeostasis	homeostasis	NN
cord-262445-54ng7m92	527	26	.	.	.
cord-262445-54ng7m92	528	1	Previous	previous	JJ
cord-262445-54ng7m92	528	2	works	work	NNS
cord-262445-54ng7m92	528	3	have	have	VBP
cord-262445-54ng7m92	528	4	shown	show	VBN
cord-262445-54ng7m92	528	5	that	that	IN
cord-262445-54ng7m92	528	6	the	the	DT
cord-262445-54ng7m92	528	7	addition	addition	NN
cord-262445-54ng7m92	528	8	of	of	IN
cord-262445-54ng7m92	528	9	OT	ot	NN
cord-262445-54ng7m92	528	10	stimulates	stimulate	VBZ
cord-262445-54ng7m92	528	11	differentiation	differentiation	NN
cord-262445-54ng7m92	528	12	of	of	IN
cord-262445-54ng7m92	528	13	myogenic	myogenic	NNP
cord-262445-54ng7m92	528	14	precursors	precursor	NNS
cord-262445-54ng7m92	528	15	and	and	CC
cord-262445-54ng7m92	528	16	induces	induce	VBZ
cord-262445-54ng7m92	528	17	myotube	myotube	NN
cord-262445-54ng7m92	528	18	hypertrophy	hypertrophy	NN
cord-262445-54ng7m92	528	19	.	.	.
cord-262445-54ng7m92	529	1	Interestingly	interestingly	RB
cord-262445-54ng7m92	529	2	,	,	,
cord-262445-54ng7m92	529	3	in	in	IN
cord-262445-54ng7m92	529	4	sarcopenia	sarcopenia	NN
cord-262445-54ng7m92	529	5	(	(	-LRB-
cord-262445-54ng7m92	529	6	senile	senile	JJ
cord-262445-54ng7m92	529	7	muscular	muscular	JJ
cord-262445-54ng7m92	529	8	atrophy	atrophy	NN
cord-262445-54ng7m92	529	9	)	)	-RRB-
cord-262445-54ng7m92	530	1	exogenous	exogenous	JJ
cord-262445-54ng7m92	530	2	OT	OT	NNP
cord-262445-54ng7m92	530	3	antagonizes	antagonize	VBZ
cord-262445-54ng7m92	530	4	skeletal	skeletal	JJ
cord-262445-54ng7m92	530	5	muscle	muscle	NN
cord-262445-54ng7m92	530	6	atrophy	atrophy	NN
cord-262445-54ng7m92	530	7	and	and	CC
cord-262445-54ng7m92	530	8	restores	restore	VBZ
cord-262445-54ng7m92	530	9	skeletal	skeletal	JJ
cord-262445-54ng7m92	530	10	muscle	muscle	NN
cord-262445-54ng7m92	530	11	trophism	trophism	NN
cord-262445-54ng7m92	530	12	in	in	IN
cord-262445-54ng7m92	530	13	mice	mouse	NNS
cord-262445-54ng7m92	530	14	.	.	.
cord-262445-54ng7m92	531	1	Neoplastic	neoplastic	JJ
cord-262445-54ng7m92	531	2	cachexia	cachexia	NN
cord-262445-54ng7m92	531	3	has	have	VBZ
cord-262445-54ng7m92	531	4	a	a	DT
cord-262445-54ng7m92	531	5	strong	strong	JJ
cord-262445-54ng7m92	531	6	negative	negative	JJ
cord-262445-54ng7m92	531	7	prognostic	prognostic	JJ
cord-262445-54ng7m92	531	8	significance	significance	NN
cord-262445-54ng7m92	531	9	in	in	IN
cord-262445-54ng7m92	531	10	cancer	cancer	NN
cord-262445-54ng7m92	531	11	patients	patient	NNS
cord-262445-54ng7m92	531	12	,	,	,
cord-262445-54ng7m92	531	13	being	be	VBG
cord-262445-54ng7m92	531	14	associated	associate	VBN
cord-262445-54ng7m92	531	15	with	with	IN
cord-262445-54ng7m92	531	16	a	a	DT
cord-262445-54ng7m92	531	17	reduction	reduction	NN
cord-262445-54ng7m92	531	18	in	in	IN
cord-262445-54ng7m92	531	19	quality	quality	NN
cord-262445-54ng7m92	531	20	of	of	IN
cord-262445-54ng7m92	531	21	life	life	NN
cord-262445-54ng7m92	531	22	and	and	CC
cord-262445-54ng7m92	531	23	response	response	NN
cord-262445-54ng7m92	531	24	to	to	IN
cord-262445-54ng7m92	531	25	therapies	therapy	NNS
cord-262445-54ng7m92	531	26	.	.	.
cord-262445-54ng7m92	532	1	Several	several	JJ
cord-262445-54ng7m92	532	2	pharmacological	pharmacological	JJ
cord-262445-54ng7m92	532	3	and	and	CC
cord-262445-54ng7m92	532	4	hormonal	hormonal	JJ
cord-262445-54ng7m92	532	5	treatment	treatment	NN
cord-262445-54ng7m92	532	6	have	have	VBP
cord-262445-54ng7m92	532	7	been	be	VBN
cord-262445-54ng7m92	532	8	proposed	propose	VBN
cord-262445-54ng7m92	532	9	to	to	TO
cord-262445-54ng7m92	532	10	counteract	counteract	VB
cord-262445-54ng7m92	532	11	cachexia	cachexia	NN
cord-262445-54ng7m92	532	12	,	,	,
cord-262445-54ng7m92	532	13	but	but	CC
cord-262445-54ng7m92	532	14	this	this	DT
cord-262445-54ng7m92	532	15	syndrome	syndrome	NN
cord-262445-54ng7m92	532	16	is	be	VBZ
cord-262445-54ng7m92	532	17	still	still	RB
cord-262445-54ng7m92	532	18	incurable	incurable	JJ
cord-262445-54ng7m92	532	19	.	.	.
cord-262445-54ng7m92	533	1	Oxytocin	oxytocin	NN
cord-262445-54ng7m92	533	2	(	(	-LRB-
cord-262445-54ng7m92	533	3	OT	OT	NNP
cord-262445-54ng7m92	533	4	)	)	-RRB-
cord-262445-54ng7m92	533	5	plays	play	VBZ
cord-262445-54ng7m92	533	6	a	a	DT
cord-262445-54ng7m92	533	7	physiological	physiological	JJ
cord-262445-54ng7m92	533	8	role	role	NN
cord-262445-54ng7m92	533	9	in	in	IN
cord-262445-54ng7m92	533	10	the	the	DT
cord-262445-54ng7m92	533	11	maintenance	maintenance	NN
cord-262445-54ng7m92	533	12	of	of	IN
cord-262445-54ng7m92	533	13	muscle	muscle	NN
cord-262445-54ng7m92	533	14	homeostasis	homeostasis	NN
cord-262445-54ng7m92	533	15	in	in	IN
cord-262445-54ng7m92	533	16	aging	age	VBG
cord-262445-54ng7m92	533	17	.	.	.
cord-262445-54ng7m92	534	1	Therefore	therefore	RB
cord-262445-54ng7m92	534	2	,	,	,
cord-262445-54ng7m92	534	3	we	-PRON-	PRP
cord-262445-54ng7m92	534	4	propose	propose	VBP
cord-262445-54ng7m92	534	5	to	to	TO
cord-262445-54ng7m92	534	6	study	study	VB
cord-262445-54ng7m92	534	7	whether	whether	IN
cord-262445-54ng7m92	534	8	the	the	DT
cord-262445-54ng7m92	534	9	administration	administration	NN
cord-262445-54ng7m92	534	10	of	of	IN
cord-262445-54ng7m92	534	11	OT	OT	NNP
cord-262445-54ng7m92	534	12	counteracts	counteract	VBZ
cord-262445-54ng7m92	534	13	skeletal	skeletal	JJ
cord-262445-54ng7m92	534	14	musculature	musculature	NN
cord-262445-54ng7m92	534	15	atrophy	atrophy	NN
cord-262445-54ng7m92	534	16	in	in	IN
cord-262445-54ng7m92	534	17	cancer	cancer	NN
cord-262445-54ng7m92	534	18	-	-	HYPH
cord-262445-54ng7m92	534	19	cachexia	cachexia	NN
cord-262445-54ng7m92	534	20	.	.	.
cord-262445-54ng7m92	535	1	To	to	TO
cord-262445-54ng7m92	535	2	mimic	mimic	VB
cord-262445-54ng7m92	535	3	cancer	cancer	NN
cord-262445-54ng7m92	535	4	cellmediated	cellmediate	VBN
cord-262445-54ng7m92	535	5	effects	effect	NNS
cord-262445-54ng7m92	535	6	on	on	IN
cord-262445-54ng7m92	535	7	muscle	muscle	NN
cord-262445-54ng7m92	535	8	cells	cell	NNS
cord-262445-54ng7m92	535	9	,	,	,
cord-262445-54ng7m92	535	10	we	-PRON-	PRP
cord-262445-54ng7m92	535	11	incubated	incubate	VBD
cord-262445-54ng7m92	535	12	L6	L6	NNP
cord-262445-54ng7m92	535	13	myoblasts	myoblast	NNS
cord-262445-54ng7m92	535	14	with	with	IN
cord-262445-54ng7m92	535	15	C26	C26	NNP
cord-262445-54ng7m92	535	16	tumor	tumor	NN
cord-262445-54ng7m92	535	17	-	-	HYPH
cord-262445-54ng7m92	535	18	conditioned	condition	VBN
cord-262445-54ng7m92	535	19	medium	medium	NN
cord-262445-54ng7m92	535	20	(	(	-LRB-
cord-262445-54ng7m92	535	21	C26	C26	NNP
cord-262445-54ng7m92	535	22	CM	CM	NNP
cord-262445-54ng7m92	535	23	)	)	-RRB-
cord-262445-54ng7m92	535	24	.	.	.
cord-262445-54ng7m92	536	1	Preliminary	preliminary	JJ
cord-262445-54ng7m92	536	2	observations	observation	NNS
cord-262445-54ng7m92	536	3	suggest	suggest	VBP
cord-262445-54ng7m92	536	4	that	that	IN
cord-262445-54ng7m92	536	5	in	in	IN
cord-262445-54ng7m92	536	6	vitro	vitro	FW
cord-262445-54ng7m92	536	7	the	the	DT
cord-262445-54ng7m92	536	8	inhibition	inhibition	NN
cord-262445-54ng7m92	536	9	of	of	IN
cord-262445-54ng7m92	536	10	differentiation	differentiation	NN
cord-262445-54ng7m92	536	11	by	by	IN
cord-262445-54ng7m92	536	12	C26	C26	NNP
cord-262445-54ng7m92	536	13	CM	CM	NNP
cord-262445-54ng7m92	536	14	is	be	VBZ
cord-262445-54ng7m92	536	15	reversed	reverse	VBN
cord-262445-54ng7m92	536	16	by	by	IN
cord-262445-54ng7m92	536	17	the	the	DT
cord-262445-54ng7m92	536	18	addition	addition	NN
cord-262445-54ng7m92	536	19	of	of	IN
cord-262445-54ng7m92	536	20	OT	ot	NN
cord-262445-54ng7m92	536	21	in	in	IN
cord-262445-54ng7m92	536	22	the	the	DT
cord-262445-54ng7m92	536	23	culture	culture	NN
cord-262445-54ng7m92	536	24	medium	medium	NN
cord-262445-54ng7m92	536	25	of	of	IN
cord-262445-54ng7m92	536	26	myogenic	myogenic	JJ
cord-262445-54ng7m92	536	27	cells	cell	NNS
cord-262445-54ng7m92	536	28	.	.	.
cord-262445-54ng7m92	537	1	We	-PRON-	PRP
cord-262445-54ng7m92	537	2	also	also	RB
cord-262445-54ng7m92	537	3	showed	show	VBD
cord-262445-54ng7m92	537	4	that	that	IN
cord-262445-54ng7m92	537	5	in	in	IN
cord-262445-54ng7m92	537	6	vivo	vivo	NN
cord-262445-54ng7m92	537	7	,	,	,
cord-262445-54ng7m92	537	8	OT	OT	NNP
cord-262445-54ng7m92	537	9	counteracts	counteract	VBZ
cord-262445-54ng7m92	537	10	the	the	DT
cord-262445-54ng7m92	537	11	TNF	TNF	NNP
cord-262445-54ng7m92	537	12	effects	effect	NNS
cord-262445-54ng7m92	537	13	on	on	IN
cord-262445-54ng7m92	537	14	muscle	muscle	NN
cord-262445-54ng7m92	537	15	regeneration	regeneration	NN
cord-262445-54ng7m92	537	16	of	of	IN
cord-262445-54ng7m92	537	17	the	the	DT
cord-262445-54ng7m92	537	18	Tibialis	Tibialis	NNP
cord-262445-54ng7m92	537	19	muscle	muscle	NN
cord-262445-54ng7m92	537	20	following	follow	VBG
cord-262445-54ng7m92	537	21	freeze	freeze	NN
cord-262445-54ng7m92	537	22	-	-	HYPH
cord-262445-54ng7m92	537	23	injury	injury	NN
cord-262445-54ng7m92	537	24	.	.	.
cord-262445-54ng7m92	538	1	Since	since	IN
cord-262445-54ng7m92	538	2	hampered	hamper	VBN
cord-262445-54ng7m92	538	3	muscle	muscle	NN
cord-262445-54ng7m92	538	4	regeneration	regeneration	NN
cord-262445-54ng7m92	538	5	and	and	CC
cord-262445-54ng7m92	538	6	satellite	satellite	NN
cord-262445-54ng7m92	538	7	cell	cell	NN
cord-262445-54ng7m92	538	8	function	function	NN
cord-262445-54ng7m92	538	9	is	be	VBZ
cord-262445-54ng7m92	538	10	a	a	DT
cord-262445-54ng7m92	538	11	key	key	JJ
cord-262445-54ng7m92	538	12	feature	feature	NN
cord-262445-54ng7m92	538	13	of	of	IN
cord-262445-54ng7m92	538	14	cachexia	cachexia	NN
cord-262445-54ng7m92	538	15	,	,	,
cord-262445-54ng7m92	538	16	contributing	contribute	VBG
cord-262445-54ng7m92	538	17	to	to	IN
cord-262445-54ng7m92	538	18	muscle	muscle	NN
cord-262445-54ng7m92	538	19	wasting	wasting	NN
cord-262445-54ng7m92	538	20	,	,	,
cord-262445-54ng7m92	538	21	our	-PRON-	PRP$
cord-262445-54ng7m92	538	22	preliminary	preliminary	JJ
cord-262445-54ng7m92	538	23	data	datum	NNS
cord-262445-54ng7m92	538	24	suggest	suggest	VBP
cord-262445-54ng7m92	538	25	that	that	IN
cord-262445-54ng7m92	538	26	indeed	indeed	RB
cord-262445-54ng7m92	538	27	OT	ot	NN
cord-262445-54ng7m92	538	28	treatment	treatment	NN
cord-262445-54ng7m92	538	29	may	may	MD
cord-262445-54ng7m92	538	30	have	have	VB
cord-262445-54ng7m92	538	31	a	a	DT
cord-262445-54ng7m92	538	32	beneficial	beneficial	JJ
cord-262445-54ng7m92	538	33	effect	effect	NN
cord-262445-54ng7m92	538	34	on	on	IN
cord-262445-54ng7m92	538	35	muscle	muscle	NN
cord-262445-54ng7m92	538	36	homeostasis	homeostasis	NN
cord-262445-54ng7m92	538	37	in	in	IN
cord-262445-54ng7m92	538	38	tumor	tumor	NN
cord-262445-54ng7m92	538	39	bearing	bear	VBG
cord-262445-54ng7m92	538	40	mice	mouse	NNS
cord-262445-54ng7m92	538	41	.	.	.
cord-262445-54ng7m92	539	1	Thanks	thank	NNS
cord-262445-54ng7m92	539	2	to	to	IN
cord-262445-54ng7m92	539	3	the	the	DT
cord-262445-54ng7m92	539	4	fact	fact	NN
cord-262445-54ng7m92	539	5	that	that	IN
cord-262445-54ng7m92	539	6	OT	OT	NNP
cord-262445-54ng7m92	539	7	is	be	VBZ
cord-262445-54ng7m92	539	8	already	already	RB
cord-262445-54ng7m92	539	9	approved	approve	VBN
cord-262445-54ng7m92	539	10	for	for	IN
cord-262445-54ng7m92	539	11	clinical	clinical	JJ
cord-262445-54ng7m92	539	12	use	use	NN
cord-262445-54ng7m92	539	13	,	,	,
cord-262445-54ng7m92	539	14	this	this	DT
cord-262445-54ng7m92	539	15	work	work	NN
cord-262445-54ng7m92	539	16	seems	seem	VBZ
cord-262445-54ng7m92	539	17	promising	promise	VBG
cord-262445-54ng7m92	539	18	to	to	TO
cord-262445-54ng7m92	539	19	prevent	prevent	VB
cord-262445-54ng7m92	539	20	cancer	cancer	NN
cord-262445-54ng7m92	539	21	-	-	HYPH
cord-262445-54ng7m92	539	22	cachexia	cachexia	NN
cord-262445-54ng7m92	539	23	skeletal	skeletal	JJ
cord-262445-54ng7m92	539	24	muscle	muscle	NN
cord-262445-54ng7m92	539	25	atrophy	atrophy	NN
cord-262445-54ng7m92	539	26	in	in	IN
cord-262445-54ng7m92	539	27	patients	patient	NNS
cord-262445-54ng7m92	539	28	.	.	.
cord-262445-54ng7m92	540	1	-41	-41	NN
cord-262445-54ng7m92	541	1	-ameliorate	-ameliorate	JJ
cord-262445-54ng7m92	541	2	muscle	muscle	NN
cord-262445-54ng7m92	541	3	wasting	wasting	NN
cord-262445-54ng7m92	541	4	.	.	.
cord-262445-54ng7m92	542	1	In	in	IN
cord-262445-54ng7m92	542	2	addition	addition	NN
cord-262445-54ng7m92	542	3	,	,	,
cord-262445-54ng7m92	542	4	we	-PRON-	PRP
cord-262445-54ng7m92	542	5	recently	recently	RB
cord-262445-54ng7m92	542	6	described	describe	VBD
cord-262445-54ng7m92	542	7	the	the	DT
cord-262445-54ng7m92	542	8	essential	essential	JJ
cord-262445-54ng7m92	542	9	role	role	NN
cord-262445-54ng7m92	542	10	of	of	IN
cord-262445-54ng7m92	542	11	autophagy	autophagy	NN
cord-262445-54ng7m92	542	12	in	in	IN
cord-262445-54ng7m92	542	13	driving	drive	VBG
cord-262445-54ng7m92	542	14	MSC	MSC	NNP
cord-262445-54ng7m92	542	15	function	function	NN
cord-262445-54ng7m92	542	16	toward	toward	IN
cord-262445-54ng7m92	542	17	efficient	efficient	JJ
cord-262445-54ng7m92	542	18	muscle	muscle	NN
cord-262445-54ng7m92	542	19	regeneration	regeneration	NN
cord-262445-54ng7m92	542	20	.	.	.
cord-262445-54ng7m92	543	1	The	the	DT
cord-262445-54ng7m92	543	2	established	establish	VBN
cord-262445-54ng7m92	543	3	role	role	NN
cord-262445-54ng7m92	543	4	of	of	IN
cord-262445-54ng7m92	543	5	autophagy	autophagy	NN
cord-262445-54ng7m92	543	6	in	in	IN
cord-262445-54ng7m92	543	7	maintaining	maintain	VBG
cord-262445-54ng7m92	543	8	muscle	muscle	NN
cord-262445-54ng7m92	543	9	mass	mass	NN
cord-262445-54ng7m92	543	10	and	and	CC
cord-262445-54ng7m92	543	11	tissue	tissue	NN
cord-262445-54ng7m92	543	12	homeostasis	homeostasis	NN
cord-262445-54ng7m92	543	13	together	together	RB
cord-262445-54ng7m92	543	14	with	with	IN
cord-262445-54ng7m92	543	15	the	the	DT
cord-262445-54ng7m92	543	16	emerging	emerge	VBG
cord-262445-54ng7m92	543	17	role	role	NN
cord-262445-54ng7m92	543	18	of	of	IN
cord-262445-54ng7m92	543	19	STAT3	STAT3	NNP
cord-262445-54ng7m92	543	20	in	in	IN
cord-262445-54ng7m92	543	21	regulating	regulate	VBG
cord-262445-54ng7m92	543	22	the	the	DT
cord-262445-54ng7m92	543	23	autophagic	autophagic	NN
cord-262445-54ng7m92	543	24	process	process	NN
cord-262445-54ng7m92	543	25	inspired	inspire	VBD
cord-262445-54ng7m92	543	26	the	the	DT
cord-262445-54ng7m92	543	27	rationale	rationale	NN
cord-262445-54ng7m92	543	28	behind	behind	IN
cord-262445-54ng7m92	543	29	this	this	DT
cord-262445-54ng7m92	543	30	work	work	NN
cord-262445-54ng7m92	543	31	which	which	WDT
cord-262445-54ng7m92	543	32	resides	reside	VBZ
cord-262445-54ng7m92	543	33	in	in	IN
cord-262445-54ng7m92	543	34	the	the	DT
cord-262445-54ng7m92	543	35	study	study	NN
cord-262445-54ng7m92	543	36	of	of	IN
cord-262445-54ng7m92	543	37	the	the	DT
cord-262445-54ng7m92	543	38	autophagic	autophagic	NNP
cord-262445-54ng7m92	543	39	contribution	contribution	NN
cord-262445-54ng7m92	543	40	in	in	IN
cord-262445-54ng7m92	543	41	mediating	mediate	VBG
cord-262445-54ng7m92	543	42	STAT3	STAT3	NNP
cord-262445-54ng7m92	543	43	signalling	signal	VBG
cord-262445-54ng7m92	543	44	toward	toward	IN
cord-262445-54ng7m92	543	45	skeletal	skeletal	JJ
cord-262445-54ng7m92	543	46	muscle	muscle	NN
cord-262445-54ng7m92	543	47	repair	repair	NN
cord-262445-54ng7m92	543	48	,	,	,
cord-262445-54ng7m92	543	49	a	a	DT
cord-262445-54ng7m92	543	50	function	function	NN
cord-262445-54ng7m92	543	51	that	that	WDT
cord-262445-54ng7m92	543	52	is	be	VBZ
cord-262445-54ng7m92	543	53	compromised	compromise	VBN
cord-262445-54ng7m92	543	54	during	during	IN
cord-262445-54ng7m92	543	55	aging	age	VBG
cord-262445-54ng7m92	543	56	.	.	.
cord-262445-54ng7m92	544	1	Our	-PRON-	PRP$
cord-262445-54ng7m92	544	2	hypothesis	hypothesis	NN
cord-262445-54ng7m92	544	3	is	be	VBZ
cord-262445-54ng7m92	544	4	that	that	IN
cord-262445-54ng7m92	544	5	STAT3	STAT3	NNP
cord-262445-54ng7m92	544	6	might	may	MD
cord-262445-54ng7m92	544	7	have	have	VB
cord-262445-54ng7m92	544	8	a	a	DT
cord-262445-54ng7m92	544	9	role	role	NN
cord-262445-54ng7m92	544	10	in	in	IN
cord-262445-54ng7m92	544	11	regulating	regulate	VBG
cord-262445-54ng7m92	544	12	myogenic	myogenic	NNP
cord-262445-54ng7m92	544	13	lineage	lineage	NN
cord-262445-54ng7m92	544	14	and	and	CC
cord-262445-54ng7m92	544	15	regeneration	regeneration	NN
cord-262445-54ng7m92	544	16	process	process	NN
cord-262445-54ng7m92	544	17	by	by	IN
cord-262445-54ng7m92	544	18	affecting	affect	VBG
cord-262445-54ng7m92	544	19	the	the	DT
cord-262445-54ng7m92	544	20	autophagic	autophagic	NN
cord-262445-54ng7m92	544	21	process	process	NN
cord-262445-54ng7m92	544	22	thereby	thereby	RB
cord-262445-54ng7m92	544	23	restoring	restore	VBG
cord-262445-54ng7m92	544	24	the	the	DT
cord-262445-54ng7m92	544	25	pro	pro	JJ
cord-262445-54ng7m92	544	26	-	-	JJ
cord-262445-54ng7m92	544	27	myogenic	myogenic	JJ
cord-262445-54ng7m92	544	28	niche	niche	NN
cord-262445-54ng7m92	544	29	that	that	WDT
cord-262445-54ng7m92	544	30	support	support	VBP
cord-262445-54ng7m92	544	31	muscle	muscle	NN
cord-262445-54ng7m92	544	32	regeneration	regeneration	NN
cord-262445-54ng7m92	544	33	.	.	.
cord-262445-54ng7m92	545	1	We	-PRON-	PRP
cord-262445-54ng7m92	545	2	show	show	VBP
cord-262445-54ng7m92	545	3	that	that	IN
cord-262445-54ng7m92	545	4	the	the	DT
cord-262445-54ng7m92	545	5	autophagic	autophagic	NNP
cord-262445-54ng7m92	545	6	process	process	NN
cord-262445-54ng7m92	545	7	influences	influence	VBZ
cord-262445-54ng7m92	545	8	MSC	MSC	NNP
cord-262445-54ng7m92	545	9	activation	activation	NN
cord-262445-54ng7m92	545	10	and	and	CC
cord-262445-54ng7m92	545	11	proliferation	proliferation	NN
cord-262445-54ng7m92	545	12	suggesting	suggest	VBG
cord-262445-54ng7m92	545	13	that	that	IN
cord-262445-54ng7m92	545	14	autophagy	autophagy	NN
cord-262445-54ng7m92	545	15	might	may	MD
cord-262445-54ng7m92	545	16	exert	exert	VB
cord-262445-54ng7m92	545	17	different	different	JJ
cord-262445-54ng7m92	545	18	functions	function	NNS
cord-262445-54ng7m92	545	19	depending	depend	VBG
cord-262445-54ng7m92	545	20	on	on	IN
cord-262445-54ng7m92	545	21	MSC	MSC	NNP
cord-262445-54ng7m92	545	22	proliferative	proliferative	JJ
cord-262445-54ng7m92	545	23	vs.	vs.	FW
cord-262445-54ng7m92	545	24	myogenic	myogenic	JJ
cord-262445-54ng7m92	545	25	state	state	NN
cord-262445-54ng7m92	545	26	and	and	CC
cord-262445-54ng7m92	545	27	in	in	IN
cord-262445-54ng7m92	545	28	muscle	muscle	NN
cord-262445-54ng7m92	545	29	fibers	fiber	NNS
cord-262445-54ng7m92	545	30	.	.	.
cord-262445-54ng7m92	546	1	Likely	likely	RB
cord-262445-54ng7m92	546	2	,	,	,
cord-262445-54ng7m92	546	3	a	a	DT
cord-262445-54ng7m92	546	4	combination	combination	NN
cord-262445-54ng7m92	546	5	of	of	IN
cord-262445-54ng7m92	546	6	autophagy	autophagy	NN
cord-262445-54ng7m92	546	7	impairment	impairment	NN
cord-262445-54ng7m92	546	8	in	in	IN
cord-262445-54ng7m92	546	9	both	both	DT
cord-262445-54ng7m92	546	10	compartments	compartment	NNS
cord-262445-54ng7m92	546	11	cooperates	cooperate	VBZ
cord-262445-54ng7m92	546	12	in	in	IN
cord-262445-54ng7m92	546	13	muscle	muscle	NN
cord-262445-54ng7m92	546	14	wasting	waste	VBG
cord-262445-54ng7m92	546	15	during	during	IN
cord-262445-54ng7m92	546	16	sarcopenia	sarcopenia	NN
cord-262445-54ng7m92	546	17	.	.	.
cord-262445-54ng7m92	547	1	Our	-PRON-	PRP$
cord-262445-54ng7m92	547	2	further	further	JJ
cord-262445-54ng7m92	547	3	analysis	analysis	NN
cord-262445-54ng7m92	547	4	indicates	indicate	VBZ
cord-262445-54ng7m92	547	5	that	that	IN
cord-262445-54ng7m92	547	6	STAT3	STAT3	NNP
cord-262445-54ng7m92	547	7	displays	display	VBZ
cord-262445-54ng7m92	547	8	nuclear	nuclear	JJ
cord-262445-54ng7m92	547	9	localization	localization	NN
cord-262445-54ng7m92	547	10	in	in	IN
cord-262445-54ng7m92	547	11	conditions	condition	NNS
cord-262445-54ng7m92	547	12	of	of	IN
cord-262445-54ng7m92	547	13	active	active	JJ
cord-262445-54ng7m92	547	14	autophagy	autophagy	NN
cord-262445-54ng7m92	547	15	-i.e	-i.e	NFP
cord-262445-54ng7m92	547	16	.	.	.
cord-262445-54ng7m92	548	1	young	young	JJ
cord-262445-54ng7m92	548	2	mice	mouse	NNS
cord-262445-54ng7m92	548	3	-	-	:
cord-262445-54ng7m92	548	4	while	while	IN
cord-262445-54ng7m92	548	5	STAT3	STAT3	NNP
cord-262445-54ng7m92	548	6	localize	localize	VBP
cord-262445-54ng7m92	548	7	in	in	IN
cord-262445-54ng7m92	548	8	the	the	DT
cord-262445-54ng7m92	548	9	cytoplasm	cytoplasm	NN
cord-262445-54ng7m92	548	10	in	in	IN
cord-262445-54ng7m92	548	11	aged	aged	JJ
cord-262445-54ng7m92	548	12	muscles	muscle	NNS
cord-262445-54ng7m92	548	13	,	,	,
cord-262445-54ng7m92	548	14	characterized	characterize	VBN
cord-262445-54ng7m92	548	15	by	by	IN
cord-262445-54ng7m92	548	16	reduced	reduce	VBN
cord-262445-54ng7m92	548	17	autophagic	autophagic	NN
cord-262445-54ng7m92	548	18	process	process	NN
cord-262445-54ng7m92	548	19	.	.	.
cord-262445-54ng7m92	549	1	Altogether	altogether	RB
cord-262445-54ng7m92	549	2	,	,	,
cord-262445-54ng7m92	549	3	these	these	DT
cord-262445-54ng7m92	549	4	evidences	evidence	NNS
cord-262445-54ng7m92	549	5	suggest	suggest	VBP
cord-262445-54ng7m92	549	6	that	that	IN
cord-262445-54ng7m92	549	7	the	the	DT
cord-262445-54ng7m92	549	8	nuclear	nuclear	JJ
cord-262445-54ng7m92	549	9	/	/	SYM
cord-262445-54ng7m92	549	10	cytoplasmic	cytoplasmic	JJ
cord-262445-54ng7m92	549	11	compartmentalization	compartmentalization	NN
cord-262445-54ng7m92	549	12	of	of	IN
cord-262445-54ng7m92	549	13	STAT3	STAT3	NNP
cord-262445-54ng7m92	549	14	regulates	regulate	VBZ
cord-262445-54ng7m92	549	15	the	the	DT
cord-262445-54ng7m92	549	16	autophagic	autophagic	NN
cord-262445-54ng7m92	549	17	process	process	NN
cord-262445-54ng7m92	549	18	and	and	CC
cord-262445-54ng7m92	549	19	the	the	DT
cord-262445-54ng7m92	549	20	regenerative	regenerative	JJ
cord-262445-54ng7m92	549	21	drive	drive	NN
cord-262445-54ng7m92	549	22	,	,	,
cord-262445-54ng7m92	549	23	highlighting	highlight	VBG
cord-262445-54ng7m92	549	24	potential	potential	JJ
cord-262445-54ng7m92	549	25	biological	biological	JJ
cord-262445-54ng7m92	549	26	targets	target	NNS
cord-262445-54ng7m92	549	27	that	that	WDT
cord-262445-54ng7m92	549	28	preclude	preclude	VBP
cord-262445-54ng7m92	549	29	an	an	DT
cord-262445-54ng7m92	549	30	efficient	efficient	JJ
cord-262445-54ng7m92	549	31	regenerative	regenerative	JJ
cord-262445-54ng7m92	549	32	response	response	NN
cord-262445-54ng7m92	549	33	in	in	IN
cord-262445-54ng7m92	549	34	aged	aged	JJ
cord-262445-54ng7m92	549	35	mice	mouse	NNS
cord-262445-54ng7m92	549	36	.	.	.
cord-262445-54ng7m92	550	1	Ageing	age	VBG
cord-262445-54ng7m92	550	2	,	,	,
cord-262445-54ng7m92	550	3	in	in	IN
cord-262445-54ng7m92	550	4	humans	human	NNS
cord-262445-54ng7m92	550	5	,	,	,
cord-262445-54ng7m92	550	6	is	be	VBZ
cord-262445-54ng7m92	550	7	characterized	characterize	VBN
cord-262445-54ng7m92	550	8	by	by	IN
cord-262445-54ng7m92	550	9	a	a	DT
cord-262445-54ng7m92	550	10	progressive	progressive	JJ
cord-262445-54ng7m92	550	11	loss	loss	NN
cord-262445-54ng7m92	550	12	of	of	IN
cord-262445-54ng7m92	550	13	muscle	muscle	NN
cord-262445-54ng7m92	550	14	mass	mass	NN
cord-262445-54ng7m92	550	15	and	and	CC
cord-262445-54ng7m92	550	16	strength	strength	NN
cord-262445-54ng7m92	550	17	,	,	,
cord-262445-54ng7m92	550	18	known	know	VBN
cord-262445-54ng7m92	550	19	as	as	IN
cord-262445-54ng7m92	550	20	sarcopenia	sarcopenia	NN
cord-262445-54ng7m92	550	21	.	.	.
cord-262445-54ng7m92	551	1	In	in	IN
cord-262445-54ng7m92	551	2	the	the	DT
cord-262445-54ng7m92	551	3	sarcopenic	sarcopenic	JJ
cord-262445-54ng7m92	551	4	muscle	muscle	NN
cord-262445-54ng7m92	551	5	,	,	,
cord-262445-54ng7m92	551	6	the	the	DT
cord-262445-54ng7m92	551	7	regenerative	regenerative	JJ
cord-262445-54ng7m92	551	8	capacity	capacity	NN
cord-262445-54ng7m92	551	9	of	of	IN
cord-262445-54ng7m92	551	10	satellite	satellite	NN
cord-262445-54ng7m92	551	11	cells	cell	NNS
cord-262445-54ng7m92	551	12	(	(	-LRB-
cord-262445-54ng7m92	551	13	SCs	SCs	NNP
cord-262445-54ng7m92	551	14	)	)	-RRB-
cord-262445-54ng7m92	551	15	,	,	,
cord-262445-54ng7m92	551	16	adult	adult	NN
cord-262445-54ng7m92	551	17	muscle	muscle	NN
cord-262445-54ng7m92	551	18	stem	stem	NN
cord-262445-54ng7m92	551	19	cells	cell	NNS
cord-262445-54ng7m92	551	20	,	,	,
cord-262445-54ng7m92	551	21	is	be	VBZ
cord-262445-54ng7m92	551	22	compromised	compromise	VBN
cord-262445-54ng7m92	551	23	.	.	.
cord-262445-54ng7m92	552	1	The	the	DT
cord-262445-54ng7m92	552	2	SCs	sc	NNS
cord-262445-54ng7m92	552	3	are	be	VBP
cord-262445-54ng7m92	552	4	responsible	responsible	JJ
cord-262445-54ng7m92	552	5	for	for	IN
cord-262445-54ng7m92	552	6	the	the	DT
cord-262445-54ng7m92	552	7	postnatal	postnatal	JJ
cord-262445-54ng7m92	552	8	muscle	muscle	NN
cord-262445-54ng7m92	552	9	growth	growth	NN
cord-262445-54ng7m92	552	10	and	and	CC
cord-262445-54ng7m92	552	11	the	the	DT
cord-262445-54ng7m92	552	12	maintenance	maintenance	NN
cord-262445-54ng7m92	552	13	of	of	IN
cord-262445-54ng7m92	552	14	muscular	muscular	JJ
cord-262445-54ng7m92	552	15	mass	mass	NN
cord-262445-54ng7m92	552	16	in	in	IN
cord-262445-54ng7m92	552	17	the	the	DT
cord-262445-54ng7m92	552	18	adulthood	adulthood	NN
cord-262445-54ng7m92	552	19	.	.	.
cord-262445-54ng7m92	553	1	These	these	DT
cord-262445-54ng7m92	553	2	cells	cell	NNS
cord-262445-54ng7m92	553	3	are	be	VBP
cord-262445-54ng7m92	553	4	the	the	DT
cord-262445-54ng7m92	553	5	main	main	JJ
cord-262445-54ng7m92	553	6	source	source	NN
cord-262445-54ng7m92	553	7	of	of	IN
cord-262445-54ng7m92	553	8	muscle	muscle	NN
cord-262445-54ng7m92	553	9	stem	stem	NN
cord-262445-54ng7m92	553	10	cells	cell	NNS
cord-262445-54ng7m92	553	11	able	able	JJ
cord-262445-54ng7m92	553	12	to	to	TO
cord-262445-54ng7m92	553	13	regenerate	regenerate	VB
cord-262445-54ng7m92	553	14	the	the	DT
cord-262445-54ng7m92	553	15	skeletal	skeletal	JJ
cord-262445-54ng7m92	553	16	muscle	muscle	NN
cord-262445-54ng7m92	553	17	tissue	tissue	NN
cord-262445-54ng7m92	553	18	.	.	.
cord-262445-54ng7m92	554	1	During	during	IN
cord-262445-54ng7m92	554	2	aging	age	VBG
cord-262445-54ng7m92	554	3	,	,	,
cord-262445-54ng7m92	554	4	the	the	DT
cord-262445-54ng7m92	554	5	myogenic	myogenic	NNP
cord-262445-54ng7m92	554	6	capability	capability	NN
cord-262445-54ng7m92	554	7	of	of	IN
cord-262445-54ng7m92	554	8	SCs	sc	NNS
cord-262445-54ng7m92	554	9	decreased	decrease	VBD
cord-262445-54ng7m92	554	10	and	and	CC
cord-262445-54ng7m92	554	11	it	-PRON-	PRP
cord-262445-54ng7m92	554	12	results	result	VBZ
cord-262445-54ng7m92	554	13	in	in	IN
cord-262445-54ng7m92	554	14	the	the	DT
cord-262445-54ng7m92	554	15	failure	failure	NN
cord-262445-54ng7m92	554	16	to	to	TO
cord-262445-54ng7m92	554	17	complete	complete	VB
cord-262445-54ng7m92	554	18	the	the	DT
cord-262445-54ng7m92	554	19	differentiation	differentiation	NN
cord-262445-54ng7m92	554	20	program	program	NN
cord-262445-54ng7m92	554	21	.	.	.
cord-262445-54ng7m92	555	1	However	however	RB
cord-262445-54ng7m92	555	2	,	,	,
cord-262445-54ng7m92	555	3	the	the	DT
cord-262445-54ng7m92	555	4	mechanisms	mechanism	NNS
cord-262445-54ng7m92	555	5	behind	behind	IN
cord-262445-54ng7m92	555	6	the	the	DT
cord-262445-54ng7m92	555	7	impaired	impaired	JJ
cord-262445-54ng7m92	555	8	myogenic	myogenic	JJ
cord-262445-54ng7m92	555	9	differentiation	differentiation	NN
cord-262445-54ng7m92	555	10	process	process	NN
cord-262445-54ng7m92	555	11	of	of	IN
cord-262445-54ng7m92	555	12	elderly	elderly	JJ
cord-262445-54ng7m92	555	13	are	be	VBP
cord-262445-54ng7m92	555	14	not	not	RB
cord-262445-54ng7m92	555	15	fully	fully	RB
cord-262445-54ng7m92	555	16	understood	understand	VBN
cord-262445-54ng7m92	555	17	.	.	.
cord-262445-54ng7m92	556	1	Moreover	moreover	RB
cord-262445-54ng7m92	556	2	,	,	,
cord-262445-54ng7m92	556	3	during	during	IN
cord-262445-54ng7m92	556	4	ageing	age	VBG
cord-262445-54ng7m92	556	5	in	in	IN
cord-262445-54ng7m92	556	6	the	the	DT
cord-262445-54ng7m92	556	7	skeletal	skeletal	JJ
cord-262445-54ng7m92	556	8	muscle	muscle	NN
cord-262445-54ng7m92	556	9	,	,	,
cord-262445-54ng7m92	556	10	there	there	EX
cord-262445-54ng7m92	556	11	is	be	VBZ
cord-262445-54ng7m92	556	12	an	an	DT
cord-262445-54ng7m92	556	13	imbalance	imbalance	NN
cord-262445-54ng7m92	556	14	between	between	IN
cord-262445-54ng7m92	556	15	reactive	reactive	JJ
cord-262445-54ng7m92	556	16	oxygen	oxygen	NN
cord-262445-54ng7m92	556	17	species	specie	NNS
cord-262445-54ng7m92	556	18	(	(	-LRB-
cord-262445-54ng7m92	556	19	ROS	ROS	NNP
cord-262445-54ng7m92	556	20	)	)	-RRB-
cord-262445-54ng7m92	556	21	production	production	NN
cord-262445-54ng7m92	556	22	and	and	CC
cord-262445-54ng7m92	556	23	antioxidant	antioxidant	JJ
cord-262445-54ng7m92	556	24	enzyme	enzyme	NN
cord-262445-54ng7m92	556	25	activity	activity	NN
cord-262445-54ng7m92	556	26	and	and	CC
cord-262445-54ng7m92	556	27	alterations	alteration	NNS
cord-262445-54ng7m92	556	28	in	in	IN
cord-262445-54ng7m92	556	29	the	the	DT
cord-262445-54ng7m92	556	30	gene	gene	NN
cord-262445-54ng7m92	556	31	expression	expression	NN
cord-262445-54ng7m92	556	32	1	1	CD
cord-262445-54ng7m92	556	33	.	.	.
cord-262445-54ng7m92	557	1	The	the	DT
cord-262445-54ng7m92	557	2	oxidative	oxidative	JJ
cord-262445-54ng7m92	557	3	stress	stress	NN
cord-262445-54ng7m92	557	4	is	be	VBZ
cord-262445-54ng7m92	557	5	harmful	harmful	JJ
cord-262445-54ng7m92	557	6	for	for	IN
cord-262445-54ng7m92	557	7	the	the	DT
cord-262445-54ng7m92	557	8	maintenance	maintenance	NN
cord-262445-54ng7m92	557	9	of	of	IN
cord-262445-54ng7m92	557	10	skeletal	skeletal	JJ
cord-262445-54ng7m92	557	11	muscle	muscle	NN
cord-262445-54ng7m92	557	12	structure	structure	NN
cord-262445-54ng7m92	557	13	and	and	CC
cord-262445-54ng7m92	557	14	function	function	NN
cord-262445-54ng7m92	557	15	,	,	,
cord-262445-54ng7m92	557	16	and	and	CC
cord-262445-54ng7m92	557	17	is	be	VBZ
cord-262445-54ng7m92	557	18	considered	consider	VBN
cord-262445-54ng7m92	557	19	one	one	CD
cord-262445-54ng7m92	557	20	of	of	IN
cord-262445-54ng7m92	557	21	the	the	DT
cord-262445-54ng7m92	557	22	main	main	JJ
cord-262445-54ng7m92	557	23	contributors	contributor	NNS
cord-262445-54ng7m92	557	24	causing	cause	VBG
cord-262445-54ng7m92	557	25	cellular	cellular	JJ
cord-262445-54ng7m92	557	26	aging	aging	NN
cord-262445-54ng7m92	557	27	.	.	.
cord-262445-54ng7m92	558	1	An	an	DT
cord-262445-54ng7m92	558	2	effective	effective	JJ
cord-262445-54ng7m92	558	3	exercise	exercise	NN
cord-262445-54ng7m92	558	4	protocol	protocol	NN
cord-262445-54ng7m92	558	5	might	may	MD
cord-262445-54ng7m92	558	6	be	be	VB
cord-262445-54ng7m92	558	7	particularly	particularly	RB
cord-262445-54ng7m92	558	8	useful	useful	JJ
cord-262445-54ng7m92	558	9	to	to	TO
cord-262445-54ng7m92	558	10	counteract	counteract	VB
cord-262445-54ng7m92	558	11	the	the	DT
cord-262445-54ng7m92	558	12	detrimental	detrimental	JJ
cord-262445-54ng7m92	558	13	decline	decline	NN
cord-262445-54ng7m92	558	14	that	that	WDT
cord-262445-54ng7m92	558	15	occurs	occur	VBZ
cord-262445-54ng7m92	558	16	in	in	IN
cord-262445-54ng7m92	558	17	sarcopenic	sarcopenic	JJ
cord-262445-54ng7m92	558	18	muscle	muscle	NN
cord-262445-54ng7m92	558	19	.	.	.
cord-262445-54ng7m92	559	1	Indeed	indeed	RB
cord-262445-54ng7m92	559	2	,	,	,
cord-262445-54ng7m92	559	3	the	the	DT
cord-262445-54ng7m92	559	4	exercise	exercise	NN
cord-262445-54ng7m92	559	5	could	could	MD
cord-262445-54ng7m92	559	6	promote	promote	VB
cord-262445-54ng7m92	559	7	cellular	cellular	JJ
cord-262445-54ng7m92	559	8	and	and	CC
cord-262445-54ng7m92	559	9	molecular	molecular	JJ
cord-262445-54ng7m92	559	10	adaptation	adaptation	NN
cord-262445-54ng7m92	559	11	mediated	mediate	VBN
cord-262445-54ng7m92	559	12	by	by	IN
cord-262445-54ng7m92	559	13	microRNAs	micrornas	JJ
cord-262445-54ng7m92	559	14	modulation	modulation	NN
cord-262445-54ng7m92	559	15	2	2	CD
cord-262445-54ng7m92	559	16	.	.	.
cord-262445-54ng7m92	560	1	Furthermore	furthermore	RB
cord-262445-54ng7m92	560	2	,	,	,
cord-262445-54ng7m92	560	3	we	-PRON-	PRP
cord-262445-54ng7m92	560	4	showed	show	VBD
cord-262445-54ng7m92	560	5	that	that	IN
cord-262445-54ng7m92	560	6	during	during	IN
cord-262445-54ng7m92	560	7	aging	age	VBG
cord-262445-54ng7m92	560	8	activated	activate	VBN
cord-262445-54ng7m92	560	9	SCs	SCs	NNP
cord-262445-54ng7m92	560	10	display	display	VBP
cord-262445-54ng7m92	560	11	a	a	DT
cord-262445-54ng7m92	560	12	complex	complex	JJ
cord-262445-54ng7m92	560	13	picture	picture	NN
cord-262445-54ng7m92	560	14	of	of	IN
cord-262445-54ng7m92	560	15	impaired	impaired	JJ
cord-262445-54ng7m92	560	16	regenerative	regenerative	JJ
cord-262445-54ng7m92	560	17	potential	potential	NN
cord-262445-54ng7m92	560	18	,	,	,
cord-262445-54ng7m92	560	19	linked	link	VBN
cord-262445-54ng7m92	560	20	to	to	IN
cord-262445-54ng7m92	560	21	altered	alter	VBN
cord-262445-54ng7m92	560	22	ROS	ROS	NNP
cord-262445-54ng7m92	560	23	production	production	NN
cord-262445-54ng7m92	560	24	and	and	CC
cord-262445-54ng7m92	560	25	miR-1	mir-1	NN
cord-262445-54ng7m92	560	26	and	and	CC
cord-262445-54ng7m92	560	27	miR-133	miR-133	NNP
cord-262445-54ng7m92	560	28	dysregulation	dysregulation	NN
cord-262445-54ng7m92	560	29	3	3	CD
cord-262445-54ng7m92	560	30	.	.	.
cord-262445-54ng7m92	561	1	The	the	DT
cord-262445-54ng7m92	561	2	aim	aim	NN
cord-262445-54ng7m92	561	3	of	of	IN
cord-262445-54ng7m92	561	4	this	this	DT
cord-262445-54ng7m92	561	5	study	study	NN
cord-262445-54ng7m92	561	6	was	be	VBD
cord-262445-54ng7m92	561	7	to	to	TO
cord-262445-54ng7m92	561	8	determine	determine	VB
cord-262445-54ng7m92	561	9	whether	whether	IN
cord-262445-54ng7m92	561	10	endurance	endurance	NN
cord-262445-54ng7m92	561	11	and	and	CC
cord-262445-54ng7m92	561	12	resistance	resistance	NN
cord-262445-54ng7m92	561	13	training	training	NN
cord-262445-54ng7m92	561	14	and	and	CC
cord-262445-54ng7m92	561	15	neuromuscular	neuromuscular	JJ
cord-262445-54ng7m92	561	16	electrical	electrical	JJ
cord-262445-54ng7m92	561	17	stimulation	stimulation	NN
cord-262445-54ng7m92	561	18	(	(	-LRB-
cord-262445-54ng7m92	561	19	NMES	NMES	NNP
cord-262445-54ng7m92	561	20	)	)	-RRB-
cord-262445-54ng7m92	561	21	affect	affect	VBP
cord-262445-54ng7m92	561	22	muscle	muscle	NN
cord-262445-54ng7m92	561	23	regeneration	regeneration	NN
cord-262445-54ng7m92	561	24	modulating	modulate	VBG
cord-262445-54ng7m92	561	25	microRNAs	microRNAs	NNPS
cord-262445-54ng7m92	561	26	and	and	CC
cord-262445-54ng7m92	561	27	oxidative	oxidative	JJ
cord-262445-54ng7m92	561	28	management	management	NN
cord-262445-54ng7m92	561	29	in	in	IN
cord-262445-54ng7m92	561	30	healthy	healthy	JJ
cord-262445-54ng7m92	561	31	elderly	elderly	JJ
cord-262445-54ng7m92	561	32	.	.	.
cord-262445-54ng7m92	562	1	To	to	TO
cord-262445-54ng7m92	562	2	achieve	achieve	VB
cord-262445-54ng7m92	562	3	this	this	DT
cord-262445-54ng7m92	562	4	goal	goal	NN
cord-262445-54ng7m92	562	5	,	,	,
cord-262445-54ng7m92	562	6	healthy	healthy	JJ
cord-262445-54ng7m92	562	7	male	male	JJ
cord-262445-54ng7m92	562	8	elderly	elderly	JJ
cord-262445-54ng7m92	562	9	subjects	subject	NNS
cord-262445-54ng7m92	562	10	(	(	-LRB-
cord-262445-54ng7m92	562	11	76.6±3.7	76.6±3.7	CD
cord-262445-54ng7m92	562	12	years	year	NNS
cord-262445-54ng7m92	562	13	;	;	:
cord-262445-54ng7m92	562	14	n=50	n=50	NN
cord-262445-54ng7m92	562	15	)	)	-RRB-
cord-262445-54ng7m92	562	16	volunteers	volunteer	NNS
cord-262445-54ng7m92	562	17	were	be	VBD
cord-262445-54ng7m92	562	18	recruited	recruit	VBN
cord-262445-54ng7m92	562	19	and	and	CC
cord-262445-54ng7m92	562	20	randomly	randomly	RB
cord-262445-54ng7m92	562	21	assigned	assign	VBN
cord-262445-54ng7m92	562	22	to	to	IN
cord-262445-54ng7m92	562	23	different	different	JJ
cord-262445-54ng7m92	562	24	training	training	NN
cord-262445-54ng7m92	562	25	and	and	CC
cord-262445-54ng7m92	562	26	control	control	NN
cord-262445-54ng7m92	562	27	groups	group	NNS
cord-262445-54ng7m92	562	28	;	;	:
cord-262445-54ng7m92	562	29	training	training	NN
cord-262445-54ng7m92	562	30	plans	plan	NNS
cord-262445-54ng7m92	562	31	consisted	consist	VBN
cord-262445-54ng7m92	562	32	in	in	IN
cord-262445-54ng7m92	562	33	12	12	CD
cord-262445-54ng7m92	562	34	weeks	week	NNS
cord-262445-54ng7m92	562	35	,	,	,
cord-262445-54ng7m92	562	36	3	3	CD
cord-262445-54ng7m92	562	37	sessions	session	NNS
cord-262445-54ng7m92	562	38	/	/	SYM
cord-262445-54ng7m92	562	39	w	w	NN
cord-262445-54ng7m92	562	40	.	.	.
cord-262445-54ng7m92	563	1	Functional	functional	JJ
cord-262445-54ng7m92	563	2	evaluation	evaluation	NN
cord-262445-54ng7m92	563	3	tests	test	NNS
cord-262445-54ng7m92	563	4	revealed	reveal	VBD
cord-262445-54ng7m92	563	5	specific	specific	JJ
cord-262445-54ng7m92	563	6	improvements	improvement	NNS
cord-262445-54ng7m92	563	7	of	of	IN
cord-262445-54ng7m92	563	8	elderly	elderly	JJ
cord-262445-54ng7m92	563	9	performance	performance	NN
cord-262445-54ng7m92	563	10	.	.	.
cord-262445-54ng7m92	564	1	Furthermore	furthermore	RB
cord-262445-54ng7m92	564	2	,	,	,
cord-262445-54ng7m92	564	3	at	at	IN
cord-262445-54ng7m92	564	4	the	the	DT
cord-262445-54ng7m92	564	5	volunteer	volunteer	NN
cord-262445-54ng7m92	564	6	were	be	VBD
cord-262445-54ng7m92	564	7	done	do	VBN
cord-262445-54ng7m92	564	8	the	the	DT
cord-262445-54ng7m92	564	9	skeletal	skeletal	JJ
cord-262445-54ng7m92	564	10	muscle	muscle	NN
cord-262445-54ng7m92	564	11	biopsy	biopsy	NN
cord-262445-54ng7m92	564	12	before	before	IN
cord-262445-54ng7m92	564	13	(	(	-LRB-
cord-262445-54ng7m92	564	14	Pre-	Pre-	NNP
cord-262445-54ng7m92	564	15	)	)	-RRB-
cord-262445-54ng7m92	564	16	and	and	CC
cord-262445-54ng7m92	564	17	after	after	IN
cord-262445-54ng7m92	564	18	(	(	-LRB-
cord-262445-54ng7m92	564	19	Post-	Post-	NNP
cord-262445-54ng7m92	564	20	)	)	-RRB-
cord-262445-54ng7m92	564	21	training	training	NN
cord-262445-54ng7m92	564	22	.	.	.
cord-262445-54ng7m92	565	1	In	in	IN
cord-262445-54ng7m92	565	2	detailed	detailed	JJ
cord-262445-54ng7m92	565	3	1	1	CD
cord-262445-54ng7m92	565	4	)	)	-RRB-
cord-262445-54ng7m92	565	5	Pre	pre	VB
cord-262445-54ng7m92	565	6	-	-	:
cord-262445-54ng7m92	565	7	and	and	CC
cord-262445-54ng7m92	565	8	Post	Post	NNP
cord-262445-54ng7m92	565	9	-	-	NNP
cord-262445-54ng7m92	565	10	SCs	sc	NNS
cord-262445-54ng7m92	565	11	were	be	VBD
cord-262445-54ng7m92	565	12	isolated	isolate	VBN
cord-262445-54ng7m92	565	13	and	and	CC
cord-262445-54ng7m92	565	14	characterized	characterize	VBN
cord-262445-54ng7m92	565	15	;	;	:
cord-262445-54ng7m92	565	16	2	2	LS
cord-262445-54ng7m92	565	17	)	)	-RRB-
cord-262445-54ng7m92	565	18	myo	myo	NN
cord-262445-54ng7m92	565	19	-	-	HYPH
cord-262445-54ng7m92	565	20	microRNAs	microRNAs	NNP
cord-262445-54ng7m92	565	21	(	(	-LRB-
cord-262445-54ng7m92	565	22	miR133a	mir133a	UH
cord-262445-54ng7m92	565	23	,	,	,
cord-262445-54ng7m92	565	24	miR133b	miR133b	NNP
cord-262445-54ng7m92	565	25	,	,	,
cord-262445-54ng7m92	565	26	miR-1	miR-1	NNP
cord-262445-54ng7m92	565	27	,	,	,
cord-262445-54ng7m92	565	28	miR206	mir206	LS
cord-262445-54ng7m92	565	29	)	)	-RRB-
cord-262445-54ng7m92	565	30	were	be	VBD
cord-262445-54ng7m92	565	31	analyzed	analyze	VBN
cord-262445-54ng7m92	565	32	;	;	:
cord-262445-54ng7m92	565	33	3	3	LS
cord-262445-54ng7m92	565	34	)	)	-RRB-
cord-262445-54ng7m92	565	35	oxidative	oxidative	JJ
cord-262445-54ng7m92	565	36	status	status	NN
cord-262445-54ng7m92	565	37	were	be	VBD
cord-262445-54ng7m92	565	38	assessed	assess	VBN
cord-262445-54ng7m92	565	39	.	.	.
cord-262445-54ng7m92	566	1	In	in	IN
cord-262445-54ng7m92	566	2	conclusion	conclusion	NN
cord-262445-54ng7m92	566	3	,	,	,
cord-262445-54ng7m92	566	4	our	-PRON-	PRP$
cord-262445-54ng7m92	566	5	data	datum	NNS
cord-262445-54ng7m92	566	6	suggested	suggest	VBD
cord-262445-54ng7m92	566	7	that	that	IN
cord-262445-54ng7m92	566	8	endurance	endurance	NN
cord-262445-54ng7m92	566	9	and	and	CC
cord-262445-54ng7m92	566	10	NMES	NMES	NNP
cord-262445-54ng7m92	566	11	protocols	protocol	NNS
cord-262445-54ng7m92	566	12	promoted	promote	VBD
cord-262445-54ng7m92	566	13	a	a	DT
cord-262445-54ng7m92	566	14	higher	high	JJR
cord-262445-54ng7m92	566	15	antioxidant	antioxidant	NN
cord-262445-54ng7m92	566	16	status	status	NN
cord-262445-54ng7m92	566	17	.	.	.
cord-262445-54ng7m92	567	1	Strikingly	strikingly	RB
cord-262445-54ng7m92	567	2	,	,	,
cord-262445-54ng7m92	567	3	we	-PRON-	PRP
cord-262445-54ng7m92	567	4	found	find	VBD
cord-262445-54ng7m92	567	5	that	that	IN
cord-262445-54ng7m92	567	6	physical	physical	JJ
cord-262445-54ng7m92	567	7	intervention	intervention	NN
cord-262445-54ng7m92	567	8	is	be	VBZ
cord-262445-54ng7m92	567	9	able	able	JJ
cord-262445-54ng7m92	567	10	to	to	TO
cord-262445-54ng7m92	567	11	modify	modify	VB
cord-262445-54ng7m92	567	12	myo	myo	NN
cord-262445-54ng7m92	567	13	-	-	HYPH
cord-262445-54ng7m92	567	14	microRNAs	micrornas	JJ
cord-262445-54ng7m92	567	15	expression	expression	NN
cord-262445-54ng7m92	567	16	.	.	.
cord-262445-54ng7m92	568	1	Indeed	indeed	RB
cord-262445-54ng7m92	568	2	,	,	,
cord-262445-54ng7m92	568	3	they	-PRON-	PRP
cord-262445-54ng7m92	568	4	were	be	VBD
cord-262445-54ng7m92	568	5	specifically	specifically	RB
cord-262445-54ng7m92	568	6	down	down	RB
cord-262445-54ng7m92	568	7	-	-	:
cord-262445-54ng7m92	568	8	or	or	CC
cord-262445-54ng7m92	568	9	up	up	RB
cord-262445-54ng7m92	568	10	-	-	HYPH
cord-262445-54ng7m92	568	11	regulated	regulate	VBN
cord-262445-54ng7m92	568	12	by	by	IN
cord-262445-54ng7m92	568	13	the	the	DT
cord-262445-54ng7m92	568	14	training	training	NN
cord-262445-54ng7m92	568	15	typologies	typology	NNS
cord-262445-54ng7m92	568	16	.	.	.
cord-262445-54ng7m92	569	1	-42	-42	NNP
cord-262445-54ng7m92	570	1	-glycosylation	-glycosylation	CD
cord-262445-54ng7m92	570	2	inhibition	inhibition	NN
cord-262445-54ng7m92	570	3	on	on	IN
cord-262445-54ng7m92	570	4	myoblast	myoblast	NN
cord-262445-54ng7m92	570	5	differentiation	differentiation	NN
cord-262445-54ng7m92	570	6	.	.	.
cord-262445-54ng7m92	571	1	C2C12	c2c12	JJ
cord-262445-54ng7m92	571	2	cells	cell	NNS
cord-262445-54ng7m92	571	3	were	be	VBD
cord-262445-54ng7m92	571	4	treated	treat	VBN
cord-262445-54ng7m92	571	5	with	with	IN
cord-262445-54ng7m92	571	6	the	the	DT
cord-262445-54ng7m92	571	7	N	n	CD
cord-262445-54ng7m92	571	8	-	-	HYPH
cord-262445-54ng7m92	571	9	glycosylation	glycosylation	NN
cord-262445-54ng7m92	571	10	inhibitor	inhibitor	NN
cord-262445-54ng7m92	571	11	tunicamycin	tunicamycin	NNS
cord-262445-54ng7m92	571	12	(	(	-LRB-
cord-262445-54ng7m92	571	13	TM	TM	NNP
cord-262445-54ng7m92	571	14	)	)	-RRB-
cord-262445-54ng7m92	571	15	(	(	-LRB-
cord-262445-54ng7m92	571	16	0.01µg	0.01µg	NN
cord-262445-54ng7m92	571	17	/	/	SYM
cord-262445-54ng7m92	571	18	ml	ml	NN
cord-262445-54ng7m92	571	19	)	)	-RRB-
cord-262445-54ng7m92	571	20	and	and	CC
cord-262445-54ng7m92	571	21	the	the	DT
cord-262445-54ng7m92	571	22	mRNA	mRNA	NNP
cord-262445-54ng7m92	571	23	expression	expression	NN
cord-262445-54ng7m92	571	24	of	of	IN
cord-262445-54ng7m92	571	25	CCND1	ccnd1	NN
cord-262445-54ng7m92	571	26	,	,	,
cord-262445-54ng7m92	571	27	Pax7	Pax7	NNP
cord-262445-54ng7m92	571	28	,	,	,
cord-262445-54ng7m92	571	29	Myogenin	Myogenin	NNP
cord-262445-54ng7m92	571	30	,	,	,
cord-262445-54ng7m92	571	31	MyoD	MyoD	NNP
cord-262445-54ng7m92	571	32	,	,	,
cord-262445-54ng7m92	571	33	MRF4	MRF4	NNP
cord-262445-54ng7m92	571	34	and	and	CC
cord-262445-54ng7m92	571	35	Desmin	Desmin	NNP
cord-262445-54ng7m92	571	36	was	be	VBD
cord-262445-54ng7m92	571	37	quantified	quantify	VBN
cord-262445-54ng7m92	571	38	in	in	IN
cord-262445-54ng7m92	571	39	proliferative	proliferative	JJ
cord-262445-54ng7m92	571	40	myoblasts	myoblast	NNS
cord-262445-54ng7m92	571	41	and	and	CC
cord-262445-54ng7m92	571	42	differentiated	differentiate	VBN
cord-262445-54ng7m92	571	43	myotubes	myotube	NNS
cord-262445-54ng7m92	571	44	.	.	.
cord-262445-54ng7m92	572	1	PCNA	PCNA	NNS
cord-262445-54ng7m92	572	2	,	,	,
cord-262445-54ng7m92	572	3	myosin	myosin	NNS
cord-262445-54ng7m92	572	4	(	(	-LRB-
cord-262445-54ng7m92	572	5	MF20	MF20	NNP
cord-262445-54ng7m92	572	6	)	)	-RRB-
cord-262445-54ng7m92	572	7	,	,	,
cord-262445-54ng7m92	572	8	IGF-1R	IGF-1R	NNP
cord-262445-54ng7m92	572	9	,	,	,
cord-262445-54ng7m92	572	10	IGF-1R	IGF-1R	NNP
cord-262445-54ng7m92	572	11	pathway	pathway	NN
cord-262445-54ng7m92	572	12	activation	activation	NN
cord-262445-54ng7m92	572	13	and	and	CC
cord-262445-54ng7m92	572	14	myogenic	myogenic	NNP
cord-262445-54ng7m92	572	15	index	index	NN
cord-262445-54ng7m92	572	16	were	be	VBD
cord-262445-54ng7m92	572	17	also	also	RB
cord-262445-54ng7m92	572	18	quantified	quantify	VBN
cord-262445-54ng7m92	572	19	by	by	IN
cord-262445-54ng7m92	572	20	western	western	JJ
cord-262445-54ng7m92	572	21	blot	blot	NN
cord-262445-54ng7m92	572	22	and	and	CC
cord-262445-54ng7m92	572	23	fluorescent	fluorescent	NN
cord-262445-54ng7m92	572	24	imaging	imaging	NN
cord-262445-54ng7m92	572	25	,	,	,
cord-262445-54ng7m92	572	26	respectively	respectively	RB
cord-262445-54ng7m92	572	27	.	.	.
cord-262445-54ng7m92	573	1	Finally	finally	RB
cord-262445-54ng7m92	573	2	,	,	,
cord-262445-54ng7m92	573	3	we	-PRON-	PRP
cord-262445-54ng7m92	573	4	tested	test	VBD
cord-262445-54ng7m92	573	5	whether	whether	IN
cord-262445-54ng7m92	573	6	the	the	DT
cord-262445-54ng7m92	573	7	siRNA	siRNA	NNP
cord-262445-54ng7m92	573	8	knockdown	knockdown	NN
cord-262445-54ng7m92	573	9	of	of	IN
cord-262445-54ng7m92	573	10	the	the	DT
cord-262445-54ng7m92	573	11	PMM2	PMM2	NNP
cord-262445-54ng7m92	573	12	gene	gene	NN
cord-262445-54ng7m92	573	13	produces	produce	VBZ
cord-262445-54ng7m92	573	14	effects	effect	NNS
cord-262445-54ng7m92	573	15	on	on	IN
cord-262445-54ng7m92	573	16	myoblast	myoblast	NN
cord-262445-54ng7m92	573	17	differentiation	differentiation	NN
cord-262445-54ng7m92	573	18	resembling	resemble	VBG
cord-262445-54ng7m92	573	19	the	the	DT
cord-262445-54ng7m92	573	20	TM	TM	NNP
cord-262445-54ng7m92	573	21	administration	administration	NN
cord-262445-54ng7m92	573	22	.	.	.
cord-262445-54ng7m92	574	1	As	as	IN
cord-262445-54ng7m92	574	2	expected	expect	VBN
cord-262445-54ng7m92	574	3	,	,	,
cord-262445-54ng7m92	574	4	CCND1	ccnd1	NN
cord-262445-54ng7m92	574	5	and	and	CC
cord-262445-54ng7m92	574	6	Pax7	Pax7	NNP
cord-262445-54ng7m92	574	7	were	be	VBD
cord-262445-54ng7m92	574	8	expressed	express	VBN
cord-262445-54ng7m92	574	9	in	in	IN
cord-262445-54ng7m92	574	10	control	control	NN
cord-262445-54ng7m92	574	11	myoblasts	myoblast	NNS
cord-262445-54ng7m92	574	12	and	and	CC
cord-262445-54ng7m92	574	13	were	be	VBD
cord-262445-54ng7m92	574	14	downregulated	downregulate	VBN
cord-262445-54ng7m92	574	15	in	in	IN
cord-262445-54ng7m92	574	16	myotubes	myotubes	NNP
cord-262445-54ng7m92	574	17	,	,	,
cord-262445-54ng7m92	574	18	while	while	IN
cord-262445-54ng7m92	574	19	Myogenin	Myogenin	NNP
cord-262445-54ng7m92	574	20	and	and	CC
cord-262445-54ng7m92	574	21	Desmin	Desmin	NNP
cord-262445-54ng7m92	574	22	showed	show	VBD
cord-262445-54ng7m92	574	23	the	the	DT
cord-262445-54ng7m92	574	24	opposite	opposite	JJ
cord-262445-54ng7m92	574	25	trend	trend	NN
cord-262445-54ng7m92	574	26	.	.	.
cord-262445-54ng7m92	575	1	TMtreated	tmtreate	VBN
cord-262445-54ng7m92	575	2	myoblasts	myoblast	NNS
cord-262445-54ng7m92	575	3	failed	fail	VBD
cord-262445-54ng7m92	575	4	to	to	TO
cord-262445-54ng7m92	575	5	down	down	RB
cord-262445-54ng7m92	575	6	-	-	HYPH
cord-262445-54ng7m92	575	7	regulate	regulate	VB
cord-262445-54ng7m92	576	1	CCND1	CCND1	NNP
cord-262445-54ng7m92	576	2	mRNA	mRNA	NNP
cord-262445-54ng7m92	577	1	after	after	IN
cord-262445-54ng7m92	577	2	induction	induction	NN
cord-262445-54ng7m92	577	3	of	of	IN
cord-262445-54ng7m92	577	4	differentiation	differentiation	NN
cord-262445-54ng7m92	577	5	and	and	CC
cord-262445-54ng7m92	577	6	the	the	DT
cord-262445-54ng7m92	577	7	expression	expression	NN
cord-262445-54ng7m92	577	8	of	of	IN
cord-262445-54ng7m92	577	9	CCND1	ccnd1	NN
cord-262445-54ng7m92	577	10	and	and	CC
cord-262445-54ng7m92	577	11	Pax7	Pax7	NNP
cord-262445-54ng7m92	577	12	remained	remain	VBD
cord-262445-54ng7m92	577	13	higher	high	JJR
cord-262445-54ng7m92	577	14	in	in	IN
cord-262445-54ng7m92	577	15	TM	TM	NNP
cord-262445-54ng7m92	577	16	-	-	HYPH
cord-262445-54ng7m92	577	17	treated	treat	VBN
cord-262445-54ng7m92	577	18	compared	compare	VBN
cord-262445-54ng7m92	577	19	to	to	IN
cord-262445-54ng7m92	577	20	control	control	VB
cord-262445-54ng7m92	577	21	myotubes	myotubes	NNP
cord-262445-54ng7m92	577	22	.	.	.
cord-262445-54ng7m92	578	1	Conversely	conversely	RB
cord-262445-54ng7m92	578	2	,	,	,
cord-262445-54ng7m92	578	3	TM	TM	NNP
cord-262445-54ng7m92	578	4	-	-	HYPH
cord-262445-54ng7m92	578	5	treated	treat	VBN
cord-262445-54ng7m92	578	6	myotubes	myotube	NNS
cord-262445-54ng7m92	578	7	expressed	express	VBD
cord-262445-54ng7m92	578	8	lower	low	JJR
cord-262445-54ng7m92	578	9	level	level	NN
cord-262445-54ng7m92	578	10	of	of	IN
cord-262445-54ng7m92	578	11	Myogenin	Myogenin	NNP
cord-262445-54ng7m92	578	12	and	and	CC
cord-262445-54ng7m92	578	13	Desmin	Desmin	NNP
cord-262445-54ng7m92	578	14	compared	compare	VBD
cord-262445-54ng7m92	578	15	to	to	IN
cord-262445-54ng7m92	578	16	control	control	NN
cord-262445-54ng7m92	578	17	.	.	.
cord-262445-54ng7m92	579	1	Moreover	moreover	RB
cord-262445-54ng7m92	579	2	,	,	,
cord-262445-54ng7m92	579	3	MF20	MF20	NNP
cord-262445-54ng7m92	579	4	protein	protein	NN
cord-262445-54ng7m92	579	5	and	and	CC
cord-262445-54ng7m92	579	6	myogenic	myogenic	NNP
cord-262445-54ng7m92	579	7	index	index	NN
cord-262445-54ng7m92	579	8	were	be	VBD
cord-262445-54ng7m92	579	9	significantly	significantly	RB
cord-262445-54ng7m92	579	10	reduced	reduce	VBN
cord-262445-54ng7m92	579	11	in	in	IN
cord-262445-54ng7m92	579	12	TM	TM	NNP
cord-262445-54ng7m92	579	13	-	-	HYPH
cord-262445-54ng7m92	579	14	treated	treat	VBN
cord-262445-54ng7m92	579	15	myotubes	myotube	NNS
cord-262445-54ng7m92	579	16	.	.	.
cord-262445-54ng7m92	580	1	Glycosylation	glycosylation	NN
cord-262445-54ng7m92	580	2	inhibition	inhibition	NN
cord-262445-54ng7m92	580	3	also	also	RB
cord-262445-54ng7m92	580	4	decreased	decrease	VBD
cord-262445-54ng7m92	580	5	the	the	DT
cord-262445-54ng7m92	580	6	IGF-1R	IGF-1R	NNP
cord-262445-54ng7m92	580	7	level	level	NN
cord-262445-54ng7m92	580	8	and	and	CC
cord-262445-54ng7m92	580	9	markedly	markedly	RB
cord-262445-54ng7m92	580	10	attenuated	attenuate	VBD
cord-262445-54ng7m92	580	11	the	the	DT
cord-262445-54ng7m92	580	12	IGF-1-induced	igf-1-induce	VBN
cord-262445-54ng7m92	580	13	ERK-1/2	ERK-1/2	NNP
cord-262445-54ng7m92	580	14	and	and	CC
cord-262445-54ng7m92	580	15	Akt	Akt	NNP
cord-262445-54ng7m92	580	16	phosphorylation	phosphorylation	NN
cord-262445-54ng7m92	580	17	.	.	.
cord-262445-54ng7m92	581	1	Interestingly	interestingly	RB
cord-262445-54ng7m92	581	2	,	,	,
cord-262445-54ng7m92	581	3	70	70	CD
cord-262445-54ng7m92	581	4	%	%	NN
cord-262445-54ng7m92	581	5	mRNA	mrna	NN
cord-262445-54ng7m92	581	6	knockdown	knockdown	NN
cord-262445-54ng7m92	581	7	of	of	IN
cord-262445-54ng7m92	581	8	PMM2	PMM2	NNP
cord-262445-54ng7m92	581	9	increased	increase	VBD
cord-262445-54ng7m92	581	10	CCND1	ccnd1	NN
cord-262445-54ng7m92	581	11	in	in	IN
cord-262445-54ng7m92	581	12	myoblasts	myoblast	NNS
cord-262445-54ng7m92	581	13	and	and	CC
cord-262445-54ng7m92	581	14	reduced	reduce	VBN
cord-262445-54ng7m92	581	15	Myogenin	Myogenin	NNP
cord-262445-54ng7m92	581	16	,	,	,
cord-262445-54ng7m92	581	17	MyoD	MyoD	NNP
cord-262445-54ng7m92	581	18	and	and	CC
cord-262445-54ng7m92	581	19	MRF4	MRF4	NNP
cord-262445-54ng7m92	582	1	mRNAs	mRNAs	NNP
cord-262445-54ng7m92	582	2	and	and	CC
cord-262445-54ng7m92	582	3	MF20	MF20	NNP
cord-262445-54ng7m92	582	4	expression	expression	NN
cord-262445-54ng7m92	582	5	in	in	IN
cord-262445-54ng7m92	582	6	myotubes	myotubes	NNP
cord-262445-54ng7m92	582	7	.	.	.
cord-262445-54ng7m92	583	1	In	in	IN
cord-262445-54ng7m92	583	2	conclusion	conclusion	NN
cord-262445-54ng7m92	583	3	,	,	,
cord-262445-54ng7m92	583	4	we	-PRON-	PRP
cord-262445-54ng7m92	583	5	found	find	VBD
cord-262445-54ng7m92	583	6	a	a	DT
cord-262445-54ng7m92	583	7	reduction	reduction	NN
cord-262445-54ng7m92	583	8	of	of	IN
cord-262445-54ng7m92	583	9	myoblast	myoblast	JJ
cord-262445-54ng7m92	583	10	differentiation	differentiation	NN
cord-262445-54ng7m92	583	11	after	after	IN
cord-262445-54ng7m92	583	12	N	n	CD
cord-262445-54ng7m92	583	13	-	-	HYPH
cord-262445-54ng7m92	583	14	glycosylation	glycosylation	NN
cord-262445-54ng7m92	583	15	inhibition	inhibition	NN
cord-262445-54ng7m92	583	16	by	by	IN
cord-262445-54ng7m92	583	17	TM	TM	NNP
cord-262445-54ng7m92	583	18	and	and	CC
cord-262445-54ng7m92	583	19	PMM2	PMM2	NNP
cord-262445-54ng7m92	583	20	silencing	silence	VBG
cord-262445-54ng7m92	583	21	.	.	.
cord-262445-54ng7m92	584	1	TM	TM	NNP
cord-262445-54ng7m92	584	2	administration	administration	NN
cord-262445-54ng7m92	584	3	also	also	RB
cord-262445-54ng7m92	584	4	affected	affect	VBD
cord-262445-54ng7m92	584	5	the	the	DT
cord-262445-54ng7m92	584	6	IGF-1R	IGF-1R	NNP
cord-262445-54ng7m92	584	7	pathway	pathway	NN
cord-262445-54ng7m92	584	8	reducing	reduce	VBG
cord-262445-54ng7m92	584	9	the	the	DT
cord-262445-54ng7m92	584	10	IGF-1R	IGF-1R	NNP
cord-262445-54ng7m92	584	11	expression	expression	NN
cord-262445-54ng7m92	584	12	and	and	CC
cord-262445-54ng7m92	584	13	inhibiting	inhibit	VBG
cord-262445-54ng7m92	584	14	ERK-1/2	ERK-1/2	NNP
cord-262445-54ng7m92	584	15	and	and	CC
cord-262445-54ng7m92	584	16	Akt	Akt	NNP
cord-262445-54ng7m92	584	17	activation	activation	NN
cord-262445-54ng7m92	584	18	.	.	.
cord-262445-54ng7m92	585	1	The	the	DT
cord-262445-54ng7m92	585	2	decrement	decrement	NN
cord-262445-54ng7m92	585	3	in	in	IN
cord-262445-54ng7m92	585	4	the	the	DT
cord-262445-54ng7m92	585	5	expression	expression	NN
cord-262445-54ng7m92	585	6	of	of	IN
cord-262445-54ng7m92	585	7	differentiation	differentiation	NN
cord-262445-54ng7m92	585	8	markers	marker	NNS
cord-262445-54ng7m92	585	9	observed	observe	VBN
cord-262445-54ng7m92	585	10	here	here	RB
cord-262445-54ng7m92	585	11	after	after	IN
cord-262445-54ng7m92	585	12	PMM2	PMM2	NNP
cord-262445-54ng7m92	585	13	silencing	silencing	NN
cord-262445-54ng7m92	585	14	,	,	,
cord-262445-54ng7m92	585	15	suggests	suggest	VBZ
cord-262445-54ng7m92	585	16	that	that	IN
cord-262445-54ng7m92	585	17	a	a	DT
cord-262445-54ng7m92	585	18	deficit	deficit	NN
cord-262445-54ng7m92	585	19	in	in	IN
cord-262445-54ng7m92	585	20	muscle	muscle	NN
cord-262445-54ng7m92	585	21	cell	cell	NN
cord-262445-54ng7m92	585	22	differentiation	differentiation	NN
cord-262445-54ng7m92	585	23	could	could	MD
cord-262445-54ng7m92	585	24	be	be	VB
cord-262445-54ng7m92	585	25	present	present	JJ
cord-262445-54ng7m92	585	26	in	in	IN
cord-262445-54ng7m92	585	27	CDG	CDG	NNP
cord-262445-54ng7m92	585	28	patients	patient	NNS
cord-262445-54ng7m92	585	29	.	.	.
cord-262445-54ng7m92	586	1	Duchenne	Duchenne	NNP
cord-262445-54ng7m92	586	2	Muscular	Muscular	NNP
cord-262445-54ng7m92	586	3	Dystrophy	Dystrophy	NNP
cord-262445-54ng7m92	586	4	(	(	-LRB-
cord-262445-54ng7m92	586	5	DMD	DMD	NNP
cord-262445-54ng7m92	586	6	)	)	-RRB-
cord-262445-54ng7m92	586	7	is	be	VBZ
cord-262445-54ng7m92	586	8	an	an	DT
cord-262445-54ng7m92	586	9	X	x	NN
cord-262445-54ng7m92	586	10	-	-	HYPH
cord-262445-54ng7m92	586	11	linked	link	VBN
cord-262445-54ng7m92	586	12	genetic	genetic	JJ
cord-262445-54ng7m92	586	13	disorder	disorder	NN
cord-262445-54ng7m92	586	14	resulting	result	VBG
cord-262445-54ng7m92	586	15	from	from	IN
cord-262445-54ng7m92	586	16	mutations	mutation	NNS
cord-262445-54ng7m92	586	17	and	and	CC
cord-262445-54ng7m92	586	18	deletions	deletion	NNS
cord-262445-54ng7m92	586	19	of	of	IN
cord-262445-54ng7m92	586	20	the	the	DT
cord-262445-54ng7m92	586	21	dystrophin	dystrophin	NN
cord-262445-54ng7m92	586	22	gene	gene	NN
cord-262445-54ng7m92	586	23	that	that	WDT
cord-262445-54ng7m92	586	24	leads	lead	VBZ
cord-262445-54ng7m92	586	25	to	to	IN
cord-262445-54ng7m92	586	26	severe	severe	JJ
cord-262445-54ng7m92	586	27	degeneration	degeneration	NN
cord-262445-54ng7m92	586	28	of	of	IN
cord-262445-54ng7m92	586	29	muscle	muscle	NN
cord-262445-54ng7m92	586	30	tissue	tissue	NN
cord-262445-54ng7m92	586	31	that	that	WDT
cord-262445-54ng7m92	586	32	is	be	VBZ
cord-262445-54ng7m92	586	33	progressively	progressively	RB
cord-262445-54ng7m92	586	34	substituted	substitute	VBN
cord-262445-54ng7m92	586	35	by	by	IN
cord-262445-54ng7m92	586	36	fat	fat	JJ
cord-262445-54ng7m92	586	37	and	and	CC
cord-262445-54ng7m92	586	38	fibrous	fibrous	JJ
cord-262445-54ng7m92	586	39	tissue	tissue	NN
cord-262445-54ng7m92	586	40	.	.	.
cord-262445-54ng7m92	587	1	Among	among	IN
cord-262445-54ng7m92	587	2	the	the	DT
cord-262445-54ng7m92	587	3	cytokines	cytokine	NNS
cord-262445-54ng7m92	587	4	involved	involve	VBN
cord-262445-54ng7m92	587	5	in	in	IN
cord-262445-54ng7m92	587	6	this	this	DT
cord-262445-54ng7m92	587	7	process	process	NN
cord-262445-54ng7m92	587	8	,	,	,
cord-262445-54ng7m92	587	9	TGF-	TGF-	NNP
cord-262445-54ng7m92	587	10	is	be	VBZ
cord-262445-54ng7m92	587	11	a	a	DT
cord-262445-54ng7m92	587	12	key	key	JJ
cord-262445-54ng7m92	587	13	player	player	NN
cord-262445-54ng7m92	587	14	polypeptide	polypeptide	NN
cord-262445-54ng7m92	587	15	that	that	WDT
cord-262445-54ng7m92	587	16	orchestrates	orchestrate	VBZ
cord-262445-54ng7m92	587	17	the	the	DT
cord-262445-54ng7m92	587	18	crosstalk	crosstalk	NN
cord-262445-54ng7m92	587	19	between	between	IN
cord-262445-54ng7m92	587	20	parenchymal	parenchymal	NN
cord-262445-54ng7m92	587	21	,	,	,
cord-262445-54ng7m92	587	22	inflammatory	inflammatory	JJ
cord-262445-54ng7m92	587	23	and	and	CC
cord-262445-54ng7m92	587	24	collagen	collagen	NN
cord-262445-54ng7m92	587	25	-	-	HYPH
cord-262445-54ng7m92	587	26	expressing	express	VBG
cord-262445-54ng7m92	587	27	cells	cell	NNS
cord-262445-54ng7m92	587	28	with	with	IN
cord-262445-54ng7m92	587	29	a	a	DT
cord-262445-54ng7m92	587	30	recognized	recognize	VBN
cord-262445-54ng7m92	587	31	pro	pro	JJ
cord-262445-54ng7m92	587	32	-	-	JJ
cord-262445-54ng7m92	587	33	fibrotic	fibrotic	JJ
cord-262445-54ng7m92	587	34	role	role	NN
cord-262445-54ng7m92	587	35	.	.	.
cord-262445-54ng7m92	588	1	In	in	IN
cord-262445-54ng7m92	588	2	DMD	DMD	NNP
cord-262445-54ng7m92	588	3	patients	patient	NNS
cord-262445-54ng7m92	588	4	,	,	,
cord-262445-54ng7m92	588	5	TGF-	TGF-	NNP
cord-262445-54ng7m92	588	6	is	be	VBZ
cord-262445-54ng7m92	588	7	elevated	elevate	VBN
cord-262445-54ng7m92	588	8	both	both	CC
cord-262445-54ng7m92	588	9	in	in	IN
cord-262445-54ng7m92	588	10	plasma	plasma	NN
cord-262445-54ng7m92	588	11	and	and	CC
cord-262445-54ng7m92	588	12	in	in	IN
cord-262445-54ng7m92	588	13	muscles	muscle	NNS
cord-262445-54ng7m92	588	14	and	and	CC
cord-262445-54ng7m92	588	15	its	-PRON-	PRP$
cord-262445-54ng7m92	588	16	expression	expression	NN
cord-262445-54ng7m92	588	17	correlates	correlate	VBZ
cord-262445-54ng7m92	588	18	with	with	IN
cord-262445-54ng7m92	588	19	increased	increase	VBN
cord-262445-54ng7m92	588	20	fibrosis	fibrosis	NN
cord-262445-54ng7m92	588	21	.	.	.
cord-262445-54ng7m92	589	1	In	in	IN
cord-262445-54ng7m92	589	2	vitro	vitro	FW
cord-262445-54ng7m92	589	3	,	,	,
cord-262445-54ng7m92	589	4	it	-PRON-	PRP
cord-262445-54ng7m92	589	5	has	have	VBZ
cord-262445-54ng7m92	589	6	been	be	VBN
cord-262445-54ng7m92	589	7	found	find	VBN
cord-262445-54ng7m92	589	8	highly	highly	RB
cord-262445-54ng7m92	589	9	expressed	express	VBN
cord-262445-54ng7m92	589	10	in	in	IN
cord-262445-54ng7m92	589	11	DMD	DMD	NNP
cord-262445-54ng7m92	589	12	myotubes	myotube	NNS
cord-262445-54ng7m92	589	13	and	and	CC
cord-262445-54ng7m92	589	14	in	in	IN
cord-262445-54ng7m92	589	15	muscle	muscle	NN
cord-262445-54ng7m92	589	16	derived	derive	VBN
cord-262445-54ng7m92	589	17	fibroblasts	fibroblast	NNS
cord-262445-54ng7m92	589	18	.	.	.
cord-262445-54ng7m92	590	1	TGF-	tgf-	JJ
cord-262445-54ng7m92	590	2	activity	activity	NN
cord-262445-54ng7m92	590	3	is	be	VBZ
cord-262445-54ng7m92	590	4	strictly	strictly	RB
cord-262445-54ng7m92	590	5	controlled	control	VBN
cord-262445-54ng7m92	590	6	at	at	IN
cord-262445-54ng7m92	590	7	various	various	JJ
cord-262445-54ng7m92	590	8	levels	level	NNS
cord-262445-54ng7m92	590	9	and	and	CC
cord-262445-54ng7m92	590	10	the	the	DT
cord-262445-54ng7m92	590	11	cytokine	cytokine	NN
cord-262445-54ng7m92	590	12	is	be	VBZ
cord-262445-54ng7m92	590	13	secreted	secrete	VBN
cord-262445-54ng7m92	590	14	as	as	IN
cord-262445-54ng7m92	590	15	a	a	DT
cord-262445-54ng7m92	590	16	latent	latent	JJ
cord-262445-54ng7m92	590	17	complex	complex	NN
cord-262445-54ng7m92	590	18	where	where	WRB
cord-262445-54ng7m92	590	19	it	-PRON-	PRP
cord-262445-54ng7m92	590	20	is	be	VBZ
cord-262445-54ng7m92	590	21	tightly	tightly	RB
cord-262445-54ng7m92	590	22	bound	bind	VBN
cord-262445-54ng7m92	590	23	to	to	IN
cord-262445-54ng7m92	590	24	the	the	DT
cord-262445-54ng7m92	590	25	so	so	RB
cord-262445-54ng7m92	590	26	-	-	HYPH
cord-262445-54ng7m92	590	27	called	call	VBN
cord-262445-54ng7m92	590	28	latent	latent	JJ
cord-262445-54ng7m92	590	29	TGF-	TGF-	NNP
cord-262445-54ng7m92	590	30	binding	bind	VBG
cord-262445-54ng7m92	590	31	protein	protein	NN
cord-262445-54ng7m92	590	32	(	(	-LRB-
cord-262445-54ng7m92	590	33	LTBP	LTBP	NNP
cord-262445-54ng7m92	590	34	)	)	-RRB-
cord-262445-54ng7m92	590	35	and	and	CC
cord-262445-54ng7m92	590	36	released	release	VBN
cord-262445-54ng7m92	590	37	as	as	IN
cord-262445-54ng7m92	590	38	active	active	JJ
cord-262445-54ng7m92	590	39	polypeptide	polypeptide	NN
cord-262445-54ng7m92	590	40	upon	upon	IN
cord-262445-54ng7m92	590	41	specific	specific	JJ
cord-262445-54ng7m92	590	42	proteolytic	proteolytic	JJ
cord-262445-54ng7m92	590	43	cleavage	cleavage	NN
cord-262445-54ng7m92	590	44	.	.	.
cord-262445-54ng7m92	591	1	Among	among	IN
cord-262445-54ng7m92	591	2	the	the	DT
cord-262445-54ng7m92	591	3	LTBPs	ltbp	NNS
cord-262445-54ng7m92	591	4	described	describe	VBN
cord-262445-54ng7m92	591	5	,	,	,
cord-262445-54ng7m92	591	6	the	the	DT
cord-262445-54ng7m92	591	7	LTBP4	ltbp4	NN
cord-262445-54ng7m92	591	8	gene	gene	NN
cord-262445-54ng7m92	591	9	was	be	VBD
cord-262445-54ng7m92	591	10	discovered	discover	VBN
cord-262445-54ng7m92	591	11	as	as	IN
cord-262445-54ng7m92	591	12	a	a	DT
cord-262445-54ng7m92	591	13	modifier	modifier	NN
cord-262445-54ng7m92	591	14	of	of	IN
cord-262445-54ng7m92	591	15	murine	murine	JJ
cord-262445-54ng7m92	591	16	muscular	muscular	JJ
cord-262445-54ng7m92	591	17	dystrophy	dystrophy	NN
cord-262445-54ng7m92	591	18	.	.	.
cord-262445-54ng7m92	592	1	Studies	study	NNS
cord-262445-54ng7m92	592	2	in	in	IN
cord-262445-54ng7m92	592	3	DMD	DMD	NNP
cord-262445-54ng7m92	592	4	patients	patient	NNS
cord-262445-54ng7m92	592	5	revealed	reveal	VBD
cord-262445-54ng7m92	592	6	that	that	IN
cord-262445-54ng7m92	592	7	four	four	CD
cord-262445-54ng7m92	592	8	LTBP4	ltbp4	NN
cord-262445-54ng7m92	592	9	SNPs	SNPs	NNPS
cord-262445-54ng7m92	592	10	were	be	VBD
cord-262445-54ng7m92	592	11	predictive	predictive	JJ
cord-262445-54ng7m92	592	12	of	of	IN
cord-262445-54ng7m92	592	13	the	the	DT
cord-262445-54ng7m92	592	14	age	age	NN
cord-262445-54ng7m92	592	15	at	at	IN
cord-262445-54ng7m92	592	16	onset	onset	NN
cord-262445-54ng7m92	592	17	of	of	IN
cord-262445-54ng7m92	592	18	loss	loss	NN
cord-262445-54ng7m92	592	19	of	of	IN
cord-262445-54ng7m92	592	20	ambulation	ambulation	NN
cord-262445-54ng7m92	592	21	and	and	CC
cord-262445-54ng7m92	592	22	of	of	IN
cord-262445-54ng7m92	592	23	dilated	dilated	JJ
cord-262445-54ng7m92	592	24	cardiomyopathy	cardiomyopathy	NN
cord-262445-54ng7m92	592	25	.	.	.
cord-262445-54ng7m92	593	1	Further	further	JJ
cord-262445-54ng7m92	593	2	studies	study	NNS
cord-262445-54ng7m92	593	3	in	in	IN
cord-262445-54ng7m92	593	4	mice	mouse	NNS
cord-262445-54ng7m92	593	5	and	and	CC
cord-262445-54ng7m92	593	6	cell	cell	NN
cord-262445-54ng7m92	593	7	culture	culture	NN
cord-262445-54ng7m92	593	8	demonstrated	demonstrate	VBD
cord-262445-54ng7m92	593	9	that	that	IN
cord-262445-54ng7m92	593	10	more	more	JJR
cord-262445-54ng7m92	593	11	TGF	TGF	NNP
cord-262445-54ng7m92	593	12	-	-	HYPH
cord-262445-54ng7m92	593	13	β	β	NNP
cord-262445-54ng7m92	593	14	is	be	VBZ
cord-262445-54ng7m92	593	15	released	release	VBN
cord-262445-54ng7m92	593	16	from	from	IN
cord-262445-54ng7m92	593	17	the	the	DT
cord-262445-54ng7m92	593	18	LTBP4	LTBP4	VBN
cord-262445-54ng7m92	593	19	VTTT	VTTT	NNP
cord-262445-54ng7m92	593	20	variant	variant	NN
cord-262445-54ng7m92	593	21	compared	compare	VBN
cord-262445-54ng7m92	593	22	to	to	IN
cord-262445-54ng7m92	593	23	the	the	DT
cord-262445-54ng7m92	593	24	IAAM	IAAM	NNP
cord-262445-54ng7m92	593	25	-	-	HYPH
cord-262445-54ng7m92	593	26	containing	contain	VBG
cord-262445-54ng7m92	593	27	LTBP4	ltbp4	NN
cord-262445-54ng7m92	593	28	variant	variant	NN
cord-262445-54ng7m92	593	29	,	,	,
cord-262445-54ng7m92	593	30	the	the	DT
cord-262445-54ng7m92	593	31	latter	latter	JJ
cord-262445-54ng7m92	593	32	being	be	VBG
cord-262445-54ng7m92	593	33	associated	associate	VBN
cord-262445-54ng7m92	593	34	with	with	IN
cord-262445-54ng7m92	593	35	older	old	JJR
cord-262445-54ng7m92	593	36	age	age	NN
cord-262445-54ng7m92	593	37	at	at	IN
cord-262445-54ng7m92	593	38	loss	loss	NN
cord-262445-54ng7m92	593	39	of	of	IN
cord-262445-54ng7m92	593	40	ambulation	ambulation	NN
cord-262445-54ng7m92	593	41	and	and	CC
cord-262445-54ng7m92	593	42	less	less	JJR
cord-262445-54ng7m92	593	43	TGF	TGF	NNP
cord-262445-54ng7m92	593	44	-	-	HYPH
cord-262445-54ng7m92	593	45	β	β	NN
cord-262445-54ng7m92	593	46	signaling	signaling	NN
cord-262445-54ng7m92	593	47	.	.	.
cord-262445-54ng7m92	594	1	Histone	Histone	NNP
cord-262445-54ng7m92	594	2	deacetylases	deacetylase	NNS
cord-262445-54ng7m92	594	3	(	(	-LRB-
cord-262445-54ng7m92	594	4	HDACs	hdac	NNS
cord-262445-54ng7m92	594	5	)	)	-RRB-
cord-262445-54ng7m92	594	6	are	be	VBP
cord-262445-54ng7m92	594	7	involved	involve	VBN
cord-262445-54ng7m92	594	8	in	in	IN
cord-262445-54ng7m92	594	9	fibrogenesis	fibrogenesis	NN
cord-262445-54ng7m92	594	10	and	and	CC
cord-262445-54ng7m92	594	11	reduction	reduction	NN
cord-262445-54ng7m92	594	12	of	of	IN
cord-262445-54ng7m92	594	13	HDAC	HDAC	NNP
cord-262445-54ng7m92	594	14	activity	activity	NN
cord-262445-54ng7m92	594	15	by	by	IN
cord-262445-54ng7m92	594	16	inhibitors	inhibitor	NNS
cord-262445-54ng7m92	594	17	targeting	target	VBG
cord-262445-54ng7m92	594	18	both	both	DT
cord-262445-54ng7m92	594	19	class	class	NN
cord-262445-54ng7m92	594	20	I	i	NN
cord-262445-54ng7m92	594	21	and	and	CC
cord-262445-54ng7m92	594	22	II	II	NNP
cord-262445-54ng7m92	594	23	,	,	,
cord-262445-54ng7m92	594	24	hinders	hinder	VBZ
cord-262445-54ng7m92	595	1	TGF	TGF	NNP
cord-262445-54ng7m92	595	2	-	-	HYPH
cord-262445-54ng7m92	595	3	β	β	NNP
cord-262445-54ng7m92	595	4	induced	induce	VBN
cord-262445-54ng7m92	595	5	fibrosis	fibrosis	NN
cord-262445-54ng7m92	595	6	.	.	.
cord-262445-54ng7m92	596	1	Moreover	moreover	RB
cord-262445-54ng7m92	596	2	,	,	,
cord-262445-54ng7m92	596	3	it	-PRON-	PRP
cord-262445-54ng7m92	596	4	was	be	VBD
cord-262445-54ng7m92	596	5	observed	observe	VBN
cord-262445-54ng7m92	596	6	that	that	IN
cord-262445-54ng7m92	596	7	our	-PRON-	PRP$
cord-262445-54ng7m92	596	8	proprietary	proprietary	JJ
cord-262445-54ng7m92	596	9	HDAC	HDAC	NNP
cord-262445-54ng7m92	596	10	inhibitor	inhibitor	NN
cord-262445-54ng7m92	596	11	givinostat	givinostat	NN
cord-262445-54ng7m92	596	12	significantly	significantly	RB
cord-262445-54ng7m92	596	13	reduced	reduce	VBD
cord-262445-54ng7m92	596	14	fibrosis	fibrosis	NN
cord-262445-54ng7m92	596	15	in	in	IN
cord-262445-54ng7m92	596	16	mdx	mdx	NNP
cord-262445-54ng7m92	596	17	mice	mouse	NNS
cord-262445-54ng7m92	596	18	and	and	CC
cord-262445-54ng7m92	596	19	in	in	IN
cord-262445-54ng7m92	596	20	DMD	DMD	NNP
cord-262445-54ng7m92	596	21	boys	boy	NNS
cord-262445-54ng7m92	596	22	.	.	.
cord-262445-54ng7m92	597	1	The	the	DT
cord-262445-54ng7m92	597	2	aim	aim	NN
cord-262445-54ng7m92	597	3	of	of	IN
cord-262445-54ng7m92	597	4	this	this	DT
cord-262445-54ng7m92	597	5	study	study	NN
cord-262445-54ng7m92	597	6	was	be	VBD
cord-262445-54ng7m92	597	7	to	to	TO
cord-262445-54ng7m92	597	8	investigate	investigate	VB
cord-262445-54ng7m92	597	9	the	the	DT
cord-262445-54ng7m92	597	10	molecular	molecular	JJ
cord-262445-54ng7m92	597	11	effects	effect	NNS
cord-262445-54ng7m92	597	12	of	of	IN
cord-262445-54ng7m92	597	13	givinostat	givinostat	NN
cord-262445-54ng7m92	597	14	on	on	IN
cord-262445-54ng7m92	597	15	TGF	TGF	NNP
cord-262445-54ng7m92	597	16	-	-	HYPH
cord-262445-54ng7m92	597	17	β	β	NNP
cord-262445-54ng7m92	597	18	induced	induce	VBN
cord-262445-54ng7m92	597	19	fibrotic	fibrotic	JJ
cord-262445-54ng7m92	597	20	gene	gene	NN
cord-262445-54ng7m92	597	21	program	program	NN
cord-262445-54ng7m92	597	22	in	in	IN
cord-262445-54ng7m92	597	23	an	an	DT
cord-262445-54ng7m92	597	24	in	in	FW
cord-262445-54ng7m92	597	25	vitro	vitro	FW
cord-262445-54ng7m92	597	26	model	model	NN
cord-262445-54ng7m92	597	27	of	of	IN
cord-262445-54ng7m92	597	28	human	human	JJ
cord-262445-54ng7m92	597	29	healthy	healthy	JJ
cord-262445-54ng7m92	597	30	and	and	CC
cord-262445-54ng7m92	597	31	DMD	DMD	NNP
cord-262445-54ng7m92	597	32	-	-	HYPH
cord-262445-54ng7m92	597	33	derived	derive	VBN
cord-262445-54ng7m92	597	34	skeletal	skeletal	JJ
cord-262445-54ng7m92	597	35	muscle	muscle	NN
cord-262445-54ng7m92	597	36	cells	cell	NNS
cord-262445-54ng7m92	597	37	.	.	.
cord-262445-54ng7m92	598	1	In	in	IN
cord-262445-54ng7m92	598	2	agreement	agreement	NN
cord-262445-54ng7m92	598	3	with	with	IN
cord-262445-54ng7m92	598	4	its	-PRON-	PRP$
cord-262445-54ng7m92	598	5	role	role	NN
cord-262445-54ng7m92	598	6	,	,	,
cord-262445-54ng7m92	598	7	TGF	TGF	NNP
cord-262445-54ng7m92	598	8	-	-	HYPH
cord-262445-54ng7m92	598	9	β	β	NNP
cord-262445-54ng7m92	598	10	induced	induce	VBD
cord-262445-54ng7m92	598	11	the	the	DT
cord-262445-54ng7m92	598	12	expression	expression	NN
cord-262445-54ng7m92	598	13	of	of	IN
cord-262445-54ng7m92	598	14	pro	pro	JJ
cord-262445-54ng7m92	598	15	-	-	JJ
cord-262445-54ng7m92	598	16	fibrotic	fibrotic	JJ
cord-262445-54ng7m92	598	17	genes	gene	NNS
cord-262445-54ng7m92	598	18	such	such	JJ
cord-262445-54ng7m92	598	19	as	as	IN
cord-262445-54ng7m92	598	20	alpha	alpha	NN
cord-262445-54ng7m92	598	21	smooth	smooth	JJ
cord-262445-54ng7m92	598	22	muscle	muscle	NN
cord-262445-54ng7m92	598	23	actin	actin	NN
cord-262445-54ng7m92	598	24	(	(	-LRB-
cord-262445-54ng7m92	598	25	SMA	SMA	NNP
cord-262445-54ng7m92	598	26	)	)	-RRB-
cord-262445-54ng7m92	598	27	,	,	,
cord-262445-54ng7m92	598	28	fibronectin	fibronectin	NN
cord-262445-54ng7m92	598	29	(	(	-LRB-
cord-262445-54ng7m92	598	30	FN1	FN1	NNP
cord-262445-54ng7m92	598	31	)	)	-RRB-
cord-262445-54ng7m92	598	32	and	and	CC
cord-262445-54ng7m92	598	33	collagen	collagen	NNP
cord-262445-54ng7m92	598	34	III	III	NNP
cord-262445-54ng7m92	598	35	,	,	,
cord-262445-54ng7m92	598	36	both	both	DT
cord-262445-54ng7m92	598	37	in	in	IN
cord-262445-54ng7m92	598	38	healthy	healthy	JJ
cord-262445-54ng7m92	598	39	and	and	CC
cord-262445-54ng7m92	598	40	DMD	DMD	NNP
cord-262445-54ng7m92	598	41	cells	cell	NNS
cord-262445-54ng7m92	598	42	.	.	.
cord-262445-54ng7m92	599	1	Givinostat	Givinostat	NNP
cord-262445-54ng7m92	599	2	clearly	clearly	RB
cord-262445-54ng7m92	599	3	reduced	reduce	VBD
cord-262445-54ng7m92	599	4	the	the	DT
cord-262445-54ng7m92	599	5	upregulation	upregulation	NN
cord-262445-54ng7m92	599	6	of	of	IN
cord-262445-54ng7m92	599	7	SMA	SMA	NNP
cord-262445-54ng7m92	599	8	and	and	CC
cord-262445-54ng7m92	599	9	FN1	FN1	NNP
cord-262445-54ng7m92	599	10	in	in	IN
cord-262445-54ng7m92	599	11	healthy	healthy	JJ
cord-262445-54ng7m92	599	12	cells	cell	NNS
cord-262445-54ng7m92	599	13	while	while	IN
cord-262445-54ng7m92	599	14	the	the	DT
cord-262445-54ng7m92	599	15	effect	effect	NN
cord-262445-54ng7m92	599	16	on	on	IN
cord-262445-54ng7m92	599	17	DMD	DMD	NNP
cord-262445-54ng7m92	599	18	cells	cell	NNS
cord-262445-54ng7m92	599	19	was	be	VBD
cord-262445-54ng7m92	599	20	negligible	negligible	JJ
cord-262445-54ng7m92	599	21	for	for	IN
cord-262445-54ng7m92	599	22	SMA	SMA	NNP
cord-262445-54ng7m92	599	23	,	,	,
cord-262445-54ng7m92	599	24	and	and	CC
cord-262445-54ng7m92	599	25	FN1	FN1	NNP
cord-262445-54ng7m92	599	26	expression	expression	NN
cord-262445-54ng7m92	599	27	was	be	VBD
cord-262445-54ng7m92	599	28	further	further	RB
cord-262445-54ng7m92	599	29	increased	increase	VBN
cord-262445-54ng7m92	599	30	.	.	.
cord-262445-54ng7m92	600	1	Downregulation	Downregulation	NNP
cord-262445-54ng7m92	600	2	of	of	IN
cord-262445-54ng7m92	600	3	collagen	collagen	NNP
cord-262445-54ng7m92	600	4	III	III	NNP
cord-262445-54ng7m92	600	5	was	be	VBD
cord-262445-54ng7m92	600	6	observed	observe	VBN
cord-262445-54ng7m92	600	7	in	in	IN
cord-262445-54ng7m92	600	8	both	both	DT
cord-262445-54ng7m92	600	9	cell	cell	NN
cord-262445-54ng7m92	600	10	types	type	NNS
cord-262445-54ng7m92	600	11	.	.	.
cord-262445-54ng7m92	601	1	A	a	DT
cord-262445-54ng7m92	601	2	different	different	JJ
cord-262445-54ng7m92	601	3	epigenetic	epigenetic	JJ
cord-262445-54ng7m92	601	4	regulation	regulation	NN
cord-262445-54ng7m92	601	5	of	of	IN
cord-262445-54ng7m92	601	6	key	key	JJ
cord-262445-54ng7m92	601	7	genes	gene	NNS
cord-262445-54ng7m92	601	8	in	in	IN
cord-262445-54ng7m92	601	9	the	the	DT
cord-262445-54ng7m92	601	10	TGF	TGF	NNP
cord-262445-54ng7m92	601	11	-	-	HYPH
cord-262445-54ng7m92	601	12	β	β	NNP
cord-262445-54ng7m92	601	13	pathway	pathway	NN
cord-262445-54ng7m92	601	14	was	be	VBD
cord-262445-54ng7m92	601	15	also	also	RB
cord-262445-54ng7m92	601	16	highlighted	highlight	VBN
cord-262445-54ng7m92	601	17	by	by	IN
cord-262445-54ng7m92	601	18	the	the	DT
cord-262445-54ng7m92	601	19	effects	effect	NNS
cord-262445-54ng7m92	601	20	on	on	IN
cord-262445-54ng7m92	601	21	the	the	DT
cord-262445-54ng7m92	601	22	expression	expression	NN
cord-262445-54ng7m92	601	23	of	of	IN
cord-262445-54ng7m92	601	24	TGF	TGF	NNP
cord-262445-54ng7m92	601	25	-	-	HYPH
cord-262445-54ng7m92	601	26	β	β	NN
cord-262445-54ng7m92	601	27	receptor	receptor	NN
cord-262445-54ng7m92	601	28	subunits	subunit	VBZ
cord-262445-54ng7m92	601	29	TGF	TGF	NNP
cord-262445-54ng7m92	601	30	R1	R1	NNP
cord-262445-54ng7m92	601	31	an	an	DT
cord-262445-54ng7m92	601	32	R2	r2	NN
cord-262445-54ng7m92	601	33	.	.	.
cord-262445-54ng7m92	602	1	Thus	thus	RB
cord-262445-54ng7m92	602	2	,	,	,
cord-262445-54ng7m92	602	3	TGF	TGF	NNP
cord-262445-54ng7m92	602	4	R1	R1	NNP
cord-262445-54ng7m92	602	5	was	be	VBD
cord-262445-54ng7m92	602	6	upregulated	upregulate	VBN
cord-262445-54ng7m92	602	7	by	by	IN
cord-262445-54ng7m92	602	8	the	the	DT
cord-262445-54ng7m92	602	9	cytokine	cytokine	NN
cord-262445-54ng7m92	602	10	and	and	CC
cord-262445-54ng7m92	602	11	downregulated	downregulate	VBN
cord-262445-54ng7m92	602	12	by	by	IN
cord-262445-54ng7m92	602	13	givinostat	givinostat	NNP
cord-262445-54ng7m92	602	14	in	in	IN
cord-262445-54ng7m92	602	15	both	both	DT
cord-262445-54ng7m92	602	16	cell	cell	NN
cord-262445-54ng7m92	602	17	types	type	NNS
cord-262445-54ng7m92	602	18	while	while	IN
cord-262445-54ng7m92	602	19	TGF	TGF	NNP
cord-262445-54ng7m92	602	20	R2	R2	NNP
cord-262445-54ng7m92	602	21	was	be	VBD
cord-262445-54ng7m92	602	22	downmodulated	downmodulate	VBN
cord-262445-54ng7m92	602	23	by	by	IN
cord-262445-54ng7m92	602	24	TGF	TGF	NNP
cord-262445-54ng7m92	602	25	-	-	HYPH
cord-262445-54ng7m92	602	26	β	β	NN
cord-262445-54ng7m92	602	27	in	in	IN
cord-262445-54ng7m92	602	28	DMD	DMD	NNP
cord-262445-54ng7m92	602	29	cells	cell	NNS
cord-262445-54ng7m92	602	30	only	only	RB
cord-262445-54ng7m92	602	31	and	and	CC
cord-262445-54ng7m92	602	32	givinostat	givinostat	NNP
cord-262445-54ng7m92	602	33	increased	increase	VBD
cord-262445-54ng7m92	602	34	its	-PRON-	PRP$
cord-262445-54ng7m92	602	35	expression	expression	NN
cord-262445-54ng7m92	602	36	in	in	IN
cord-262445-54ng7m92	602	37	both	both	DT
cord-262445-54ng7m92	602	38	cell	cell	NN
cord-262445-54ng7m92	602	39	types	type	NNS
cord-262445-54ng7m92	602	40	.	.	.
cord-262445-54ng7m92	603	1	A	a	DT
cord-262445-54ng7m92	603	2	differential	differential	JJ
cord-262445-54ng7m92	603	3	regulation	regulation	NN
cord-262445-54ng7m92	603	4	of	of	IN
cord-262445-54ng7m92	603	5	matrix	matrix	NN
cord-262445-54ng7m92	603	6	metalloproteinases	metalloproteinase	NNS
cord-262445-54ng7m92	603	7	and	and	CC
cord-262445-54ng7m92	603	8	their	-PRON-	PRP$
cord-262445-54ng7m92	603	9	inhibitors	inhibitor	NNS
cord-262445-54ng7m92	603	10	was	be	VBD
cord-262445-54ng7m92	603	11	also	also	RB
cord-262445-54ng7m92	603	12	observed	observe	VBN
cord-262445-54ng7m92	603	13	.	.	.
cord-262445-54ng7m92	604	1	These	these	DT
cord-262445-54ng7m92	604	2	data	datum	NNS
cord-262445-54ng7m92	604	3	emphasize	emphasize	VBP
cord-262445-54ng7m92	604	4	how	how	WRB
cord-262445-54ng7m92	604	5	a	a	DT
cord-262445-54ng7m92	604	6	different	different	JJ
cord-262445-54ng7m92	604	7	epigenetic	epigenetic	JJ
cord-262445-54ng7m92	604	8	regulation	regulation	NN
cord-262445-54ng7m92	604	9	of	of	IN
cord-262445-54ng7m92	604	10	key	key	JJ
cord-262445-54ng7m92	604	11	fibrotic	fibrotic	JJ
cord-262445-54ng7m92	604	12	genes	gene	NNS
cord-262445-54ng7m92	604	13	takes	take	VBZ
cord-262445-54ng7m92	604	14	place	place	NN
cord-262445-54ng7m92	604	15	in	in	IN
cord-262445-54ng7m92	604	16	healthy	healthy	JJ
cord-262445-54ng7m92	604	17	and	and	CC
cord-262445-54ng7m92	604	18	DMD	DMD	NNP
cord-262445-54ng7m92	604	19	cells	cell	NNS
cord-262445-54ng7m92	604	20	.	.	.
cord-262445-54ng7m92	605	1	Furthermore	furthermore	RB
cord-262445-54ng7m92	605	2	,	,	,
cord-262445-54ng7m92	605	3	they	-PRON-	PRP
cord-262445-54ng7m92	605	4	also	also	RB
cord-262445-54ng7m92	605	5	highlight	highlight	VBP
cord-262445-54ng7m92	605	6	the	the	DT
cord-262445-54ng7m92	605	7	importance	importance	NN
cord-262445-54ng7m92	605	8	of	of	IN
cord-262445-54ng7m92	605	9	having	have	VBG
cord-262445-54ng7m92	605	10	an	an	DT
cord-262445-54ng7m92	605	11	in	in	FW
cord-262445-54ng7m92	605	12	vitro	vitro	FW
cord-262445-54ng7m92	605	13	model	model	NN
cord-262445-54ng7m92	605	14	whereby	whereby	WRB
cord-262445-54ng7m92	605	15	both	both	CC
cord-262445-54ng7m92	605	16	healthy	healthy	JJ
cord-262445-54ng7m92	605	17	and	and	CC
cord-262445-54ng7m92	605	18	DMD	DMD	NNP
cord-262445-54ng7m92	605	19	cells	cell	NNS
cord-262445-54ng7m92	605	20	are	be	VBP
cord-262445-54ng7m92	605	21	used	use	VBN
cord-262445-54ng7m92	605	22	to	to	TO
cord-262445-54ng7m92	605	23	study	study	VB
cord-262445-54ng7m92	605	24	the	the	DT
cord-262445-54ng7m92	605	25	specific	specific	JJ
cord-262445-54ng7m92	605	26	pathways	pathway	NNS
cord-262445-54ng7m92	605	27	that	that	WDT
cord-262445-54ng7m92	605	28	can	can	MD
cord-262445-54ng7m92	605	29	be	be	VB
cord-262445-54ng7m92	605	30	targeted	target	VBN
cord-262445-54ng7m92	605	31	in	in	IN
cord-262445-54ng7m92	605	32	diseased	diseased	JJ
cord-262445-54ng7m92	605	33	cells	cell	NNS
cord-262445-54ng7m92	605	34	to	to	IN
cord-262445-54ng7m92	605	35	more	more	RBR
cord-262445-54ng7m92	605	36	accurately	accurately	RB
cord-262445-54ng7m92	605	37	advance	advance	JJ
cord-262445-54ng7m92	605	38	drug	drug	NN
cord-262445-54ng7m92	605	39	candidates	candidate	NNS
cord-262445-54ng7m92	605	40	into	into	IN
cord-262445-54ng7m92	605	41	in	in	IN
cord-262445-54ng7m92	605	42	vivo	vivo	NN
cord-262445-54ng7m92	605	43	studies	study	NNS
cord-262445-54ng7m92	605	44	.	.	.
cord-262445-54ng7m92	606	1	Introduction	introduction	NN
cord-262445-54ng7m92	606	2	:	:	:
cord-262445-54ng7m92	607	1	Cancer	cancer	NN
cord-262445-54ng7m92	607	2	-	-	HYPH
cord-262445-54ng7m92	607	3	associated	associate	VBN
cord-262445-54ng7m92	607	4	cachexia	cachexia	NN
cord-262445-54ng7m92	607	5	is	be	VBZ
cord-262445-54ng7m92	607	6	a	a	DT
cord-262445-54ng7m92	607	7	multifactorial	multifactorial	JJ
cord-262445-54ng7m92	607	8	syndrome	syndrome	NN
cord-262445-54ng7m92	607	9	characterized	characterize	VBN
cord-262445-54ng7m92	607	10	by	by	IN
cord-262445-54ng7m92	607	11	anorexia	anorexia	NN
cord-262445-54ng7m92	607	12	and	and	CC
cord-262445-54ng7m92	607	13	body	body	NN
cord-262445-54ng7m92	607	14	weight	weight	NN
cord-262445-54ng7m92	607	15	loss	loss	NN
cord-262445-54ng7m92	607	16	,	,	,
cord-262445-54ng7m92	607	17	mainly	mainly	RB
cord-262445-54ng7m92	607	18	due	due	IN
cord-262445-54ng7m92	607	19	to	to	IN
cord-262445-54ng7m92	607	20	muscle	muscle	NN
cord-262445-54ng7m92	607	21	and	and	CC
cord-262445-54ng7m92	607	22	fat	fat	JJ
cord-262445-54ng7m92	607	23	wasting	wasting	NN
cord-262445-54ng7m92	607	24	(	(	-LRB-
cord-262445-54ng7m92	607	25	1	1	CD
cord-262445-54ng7m92	607	26	)	)	-RRB-
cord-262445-54ng7m92	607	27	.	.	.
cord-262445-54ng7m92	608	1	MicroRNAs	MicroRNAs	NNP
cord-262445-54ng7m92	609	1	(	(	-LRB-
cord-262445-54ng7m92	609	2	miRNAs	miRNAs	NNP
cord-262445-54ng7m92	609	3	)	)	-RRB-
cord-262445-54ng7m92	609	4	are	be	VBP
cord-262445-54ng7m92	609	5	a	a	DT
cord-262445-54ng7m92	609	6	class	class	NN
cord-262445-54ng7m92	609	7	of	of	IN
cord-262445-54ng7m92	609	8	non	non	JJ
cord-262445-54ng7m92	609	9	-	-	JJ
cord-262445-54ng7m92	609	10	coding	code	VBG
cord-262445-54ng7m92	609	11	posttranscriptional	posttranscriptional	JJ
cord-262445-54ng7m92	609	12	regulators	regulator	NNS
cord-262445-54ng7m92	609	13	that	that	WDT
cord-262445-54ng7m92	609	14	play	play	VBP
cord-262445-54ng7m92	609	15	,	,	,
cord-262445-54ng7m92	609	16	among	among	IN
cord-262445-54ng7m92	609	17	other	other	JJ
cord-262445-54ng7m92	609	18	functions	function	NNS
cord-262445-54ng7m92	609	19	,	,	,
cord-262445-54ng7m92	609	20	a	a	DT
cord-262445-54ng7m92	609	21	central	central	JJ
cord-262445-54ng7m92	609	22	role	role	NN
cord-262445-54ng7m92	609	23	in	in	IN
cord-262445-54ng7m92	609	24	appropriated	appropriate	VBN
cord-262445-54ng7m92	609	25	muscle	muscle	NN
cord-262445-54ng7m92	609	26	cell	cell	NN
cord-262445-54ng7m92	609	27	commitment	commitment	NN
cord-262445-54ng7m92	609	28	,	,	,
cord-262445-54ng7m92	609	29	proliferation	proliferation	NN
cord-262445-54ng7m92	609	30	and	and	CC
cord-262445-54ng7m92	609	31	differentiation	differentiation	NN
cord-262445-54ng7m92	609	32	by	by	IN
cord-262445-54ng7m92	609	33	modulating	modulate	VBG
cord-262445-54ng7m92	609	34	the	the	DT
cord-262445-54ng7m92	609	35	translation	translation	NN
cord-262445-54ng7m92	609	36	of	of	IN
cord-262445-54ng7m92	609	37	specific	specific	JJ
cord-262445-54ng7m92	609	38	genes	gene	NNS
cord-262445-54ng7m92	609	39	(	(	-LRB-
cord-262445-54ng7m92	609	40	2	2	CD
cord-262445-54ng7m92	609	41	)	)	-RRB-
cord-262445-54ng7m92	609	42	.	.	.
cord-262445-54ng7m92	610	1	The	the	DT
cord-262445-54ng7m92	610	2	present	present	JJ
cord-262445-54ng7m92	610	3	study	study	NN
cord-262445-54ng7m92	610	4	was	be	VBD
cord-262445-54ng7m92	610	5	aimed	aim	VBN
cord-262445-54ng7m92	610	6	to	to	TO
cord-262445-54ng7m92	610	7	evaluate	evaluate	VB
cord-262445-54ng7m92	610	8	the	the	DT
cord-262445-54ng7m92	610	9	possibility	possibility	NN
cord-262445-54ng7m92	610	10	to	to	TO
cord-262445-54ng7m92	610	11	use	use	VB
cord-262445-54ng7m92	610	12	dysregulated	dysregulated	JJ
cord-262445-54ng7m92	610	13	miRNAs	miRNAs	NNP
cord-262445-54ng7m92	610	14	as	as	IN
cord-262445-54ng7m92	610	15	biomarkers	biomarker	NNS
cord-262445-54ng7m92	610	16	of	of	IN
cord-262445-54ng7m92	610	17	cancer	cancer	NN
cord-262445-54ng7m92	610	18	cachexia	cachexia	NN
cord-262445-54ng7m92	610	19	.	.	.
cord-262445-54ng7m92	611	1	Methods	method	NNS
cord-262445-54ng7m92	611	2	:	:	:
cord-262445-54ng7m92	611	3	Total	Total	NNP
cord-262445-54ng7m92	611	4	RNA	RNA	NNP
cord-262445-54ng7m92	611	5	was	be	VBD
cord-262445-54ng7m92	611	6	extracted	extract	VBN
cord-262445-54ng7m92	611	7	from	from	IN
cord-262445-54ng7m92	611	8	both	both	DT
cord-262445-54ng7m92	611	9	skeletal	skeletal	JJ
cord-262445-54ng7m92	611	10	muscles	muscle	NNS
cord-262445-54ng7m92	611	11	and	and	CC
cord-262445-54ng7m92	611	12	plasma	plasma	NN
cord-262445-54ng7m92	611	13	-	-	HYPH
cord-262445-54ng7m92	611	14	derived	derive	VBN
cord-262445-54ng7m92	611	15	microvesicles	microvesicle	NNS
cord-262445-54ng7m92	611	16	from	from	IN
cord-262445-54ng7m92	611	17	controls	control	NNS
cord-262445-54ng7m92	611	18	and	and	CC
cord-262445-54ng7m92	611	19	C26	C26	NNP
cord-262445-54ng7m92	611	20	tumor	tumor	NN
cord-262445-54ng7m92	611	21	-	-	HYPH
cord-262445-54ng7m92	611	22	bearing	bear	VBG
cord-262445-54ng7m92	611	23	Balb	Balb	NNP
cord-262445-54ng7m92	611	24	/	/	SYM
cord-262445-54ng7m92	611	25	c	c	NN
cord-262445-54ng7m92	611	26	mice	mouse	NNS
cord-262445-54ng7m92	611	27	.	.	.
cord-262445-54ng7m92	612	1	Next	next	JJ
cord-262445-54ng7m92	612	2	-	-	HYPH
cord-262445-54ng7m92	612	3	generation	generation	NN
cord-262445-54ng7m92	612	4	sequencing	sequencing	NN
cord-262445-54ng7m92	612	5	(	(	-LRB-
cord-262445-54ng7m92	612	6	NGS	NGS	NNP
cord-262445-54ng7m92	612	7	)	)	-RRB-
cord-262445-54ng7m92	612	8	was	be	VBD
cord-262445-54ng7m92	612	9	used	use	VBN
cord-262445-54ng7m92	612	10	to	to	TO
cord-262445-54ng7m92	612	11	sequence	sequence	VB
cord-262445-54ng7m92	612	12	whole	whole	JJ
cord-262445-54ng7m92	612	13	miRNA	miRNA	NNP
cord-262445-54ng7m92	612	14	transcriptome	transcriptome	NN
cord-262445-54ng7m92	612	15	.	.	.
cord-262445-54ng7m92	613	1	Those	those	DT
cord-262445-54ng7m92	613	2	miRNAs	miRNAs	NNP
cord-262445-54ng7m92	613	3	differentially	differentially	RB
cord-262445-54ng7m92	613	4	regulated	regulate	VBN
cord-262445-54ng7m92	613	5	were	be	VBD
cord-262445-54ng7m92	613	6	validated	validate	VBN
cord-262445-54ng7m92	613	7	by	by	IN
cord-262445-54ng7m92	613	8	Real	Real	NNP
cord-262445-54ng7m92	613	9	Time	Time	NNP
cord-262445-54ng7m92	613	10	PCR	PCR	NNP
cord-262445-54ng7m92	613	11	.	.	.
cord-262445-54ng7m92	614	1	Results	result	NNS
cord-262445-54ng7m92	614	2	:	:	:
cord-262445-54ng7m92	615	1	Clear	clear	JJ
cord-262445-54ng7m92	615	2	differences	difference	NNS
cord-262445-54ng7m92	615	3	in	in	IN
cord-262445-54ng7m92	615	4	miRNA	miRNA	NNP
cord-262445-54ng7m92	615	5	expression	expression	NN
cord-262445-54ng7m92	615	6	between	between	IN
cord-262445-54ng7m92	615	7	the	the	DT
cord-262445-54ng7m92	615	8	two	two	CD
cord-262445-54ng7m92	615	9	experimental	experimental	JJ
cord-262445-54ng7m92	615	10	groups	group	NNS
cord-262445-54ng7m92	615	11	were	be	VBD
cord-262445-54ng7m92	615	12	observed	observe	VBN
cord-262445-54ng7m92	615	13	.	.	.
cord-262445-54ng7m92	616	1	In	in	IN
cord-262445-54ng7m92	616	2	particular	particular	JJ
cord-262445-54ng7m92	616	3	,	,	,
cord-262445-54ng7m92	616	4	miR-21a-5p	miR-21a-5p	NNP
cord-262445-54ng7m92	616	5	,	,	,
cord-262445-54ng7m92	616	6	miR-29a-3p	miR-29a-3p	NNP
cord-262445-54ng7m92	616	7	,	,	,
cord-262445-54ng7m92	616	8	miR-29c-3p	miR-29c-3p	NNP
cord-262445-54ng7m92	616	9	,	,	,
cord-262445-54ng7m92	616	10	miR-185	mir-185	NN
cord-262445-54ng7m92	616	11	-	-	HYPH
cord-262445-54ng7m92	616	12	5p	5p	NNP
cord-262445-54ng7m92	616	13	,	,	,
cord-262445-54ng7m92	616	14	miR-185	mir-185	NN
cord-262445-54ng7m92	616	15	-	-	HYPH
cord-262445-54ng7m92	616	16	3p	3p	CD
cord-262445-54ng7m92	616	17	,	,	,
cord-262445-54ng7m92	616	18	miR-223	mir-223	NN
cord-262445-54ng7m92	616	19	-	-	NNS
cord-262445-54ng7m92	616	20	3p	3p	CD
cord-262445-54ng7m92	616	21	were	be	VBD
cord-262445-54ng7m92	616	22	statistically	statistically	RB
cord-262445-54ng7m92	616	23	upregulated	upregulate	VBN
cord-262445-54ng7m92	616	24	in	in	IN
cord-262445-54ng7m92	616	25	the	the	DT
cord-262445-54ng7m92	616	26	tumor	tumor	NN
cord-262445-54ng7m92	616	27	-	-	HYPH
cord-262445-54ng7m92	616	28	bearing	bear	VBG
cord-262445-54ng7m92	616	29	mice	mouse	NNS
cord-262445-54ng7m92	616	30	.	.	.
cord-262445-54ng7m92	617	1	By	by	IN
cord-262445-54ng7m92	617	2	contrast	contrast	NN
cord-262445-54ng7m92	617	3	,	,	,
cord-262445-54ng7m92	617	4	miRNAs	miRNAs	NNP
cord-262445-54ng7m92	617	5	from	from	IN
cord-262445-54ng7m92	617	6	microvesicles	microvesicle	NNS
cord-262445-54ng7m92	617	7	were	be	VBD
cord-262445-54ng7m92	617	8	poorly	poorly	RB
cord-262445-54ng7m92	617	9	modulated	modulate	VBN
cord-262445-54ng7m92	617	10	in	in	IN
cord-262445-54ng7m92	617	11	the	the	DT
cord-262445-54ng7m92	617	12	C26	C26	NNP
cord-262445-54ng7m92	617	13	host	host	NN
cord-262445-54ng7m92	617	14	,	,	,
cord-262445-54ng7m92	617	15	only	only	RB
cord-262445-54ng7m92	617	16	three	three	CD
cord-262445-54ng7m92	617	17	miRNAs	miRNAs	NNP
cord-262445-54ng7m92	617	18	(	(	-LRB-
cord-262445-54ng7m92	617	19	miR-181a-5p	miR-181a-5p	NNP
cord-262445-54ng7m92	617	20	,	,	,
cord-262445-54ng7m92	617	21	miR-375	mir-375	NN
cord-262445-54ng7m92	617	22	-	-	HYPH
cord-262445-54ng7m92	617	23	3p	3p	CD
cord-262445-54ng7m92	617	24	,	,	,
cord-262445-54ng7m92	617	25	miR-455	mir-455	NN
cord-262445-54ng7m92	617	26	-	-	HYPH
cord-262445-54ng7m92	617	27	5p	5p	CD
cord-262445-54ng7m92	617	28	)	)	-RRB-
cord-262445-54ng7m92	617	29	were	be	VBD
cord-262445-54ng7m92	617	30	found	find	VBN
cord-262445-54ng7m92	617	31	dysregulated	dysregulate	VBN
cord-262445-54ng7m92	617	32	at	at	IN
cord-262445-54ng7m92	617	33	NGS	NGS	NNP
cord-262445-54ng7m92	617	34	analysis	analysis	NN
cord-262445-54ng7m92	617	35	,	,	,
cord-262445-54ng7m92	617	36	suggesting	suggest	VBG
cord-262445-54ng7m92	617	37	that	that	IN
cord-262445-54ng7m92	617	38	their	-PRON-	PRP$
cord-262445-54ng7m92	617	39	use	use	NN
cord-262445-54ng7m92	617	40	as	as	IN
cord-262445-54ng7m92	617	41	a	a	DT
cord-262445-54ng7m92	617	42	circulating	circulate	VBG
cord-262445-54ng7m92	617	43	biomarker	biomarker	NN
cord-262445-54ng7m92	617	44	might	may	MD
cord-262445-54ng7m92	617	45	be	be	VB
cord-262445-54ng7m92	617	46	limited	limit	VBN
cord-262445-54ng7m92	617	47	.	.	.
cord-262445-54ng7m92	618	1	Conclusion	conclusion	NN
cord-262445-54ng7m92	618	2	:	:	:
cord-262445-54ng7m92	619	1	The	the	DT
cord-262445-54ng7m92	619	2	results	result	NNS
cord-262445-54ng7m92	619	3	obtained	obtain	VBN
cord-262445-54ng7m92	619	4	in	in	IN
cord-262445-54ng7m92	619	5	the	the	DT
cord-262445-54ng7m92	619	6	present	present	JJ
cord-262445-54ng7m92	619	7	study	study	NN
cord-262445-54ng7m92	619	8	suggest	suggest	VBP
cord-262445-54ng7m92	619	9	that	that	IN
cord-262445-54ng7m92	619	10	modulations	modulation	NNS
cord-262445-54ng7m92	619	11	of	of	IN
cord-262445-54ng7m92	619	12	the	the	DT
cord-262445-54ng7m92	619	13	skeletal	skeletal	JJ
cord-262445-54ng7m92	619	14	muscle	muscle	NN
cord-262445-54ng7m92	619	15	miRNAome	miRNAome	NNP
cord-262445-54ng7m92	619	16	can	can	MD
cord-262445-54ng7m92	619	17	be	be	VB
cord-262445-54ng7m92	619	18	used	use	VBN
cord-262445-54ng7m92	619	19	as	as	IN
cord-262445-54ng7m92	619	20	effective	effective	JJ
cord-262445-54ng7m92	619	21	biomarkers	biomarker	NNS
cord-262445-54ng7m92	619	22	in	in	IN
cord-262445-54ng7m92	619	23	the	the	DT
cord-262445-54ng7m92	619	24	pathogenesis	pathogenesis	NN
cord-262445-54ng7m92	619	25	of	of	IN
cord-262445-54ng7m92	619	26	cancer	cancer	NN
cord-262445-54ng7m92	619	27	-	-	HYPH
cord-262445-54ng7m92	619	28	associated	associate	VBN
cord-262445-54ng7m92	619	29	cachexia	cachexia	NN
cord-262445-54ng7m92	619	30	in	in	IN
cord-262445-54ng7m92	619	31	murine	murine	JJ
cord-262445-54ng7m92	619	32	models	model	NNS
cord-262445-54ng7m92	619	33	.	.	.
cord-262445-54ng7m92	620	1	-44	-44	NN
cord-262445-54ng7m92	621	1	-decreases	-decrease	NNS
cord-262445-54ng7m92	621	2	in	in	IN
cord-262445-54ng7m92	621	3	C26	C26	NNP
cord-262445-54ng7m92	621	4	tumor	tumor	NN
cord-262445-54ng7m92	621	5	bearing	bear	VBG
cord-262445-54ng7m92	621	6	mice	mouse	NNS
cord-262445-54ng7m92	621	7	,	,	,
cord-262445-54ng7m92	621	8	and	and	CC
cord-262445-54ng7m92	621	9	that	that	DT
cord-262445-54ng7m92	621	10	exercise	exercise	NN
cord-262445-54ng7m92	621	11	can	can	MD
cord-262445-54ng7m92	621	12	rescue	rescue	VB
cord-262445-54ng7m92	621	13	.	.	.
cord-262445-54ng7m92	622	1	Indeed	indeed	RB
cord-262445-54ng7m92	622	2	,	,	,
cord-262445-54ng7m92	622	3	we	-PRON-	PRP
cord-262445-54ng7m92	622	4	showed	show	VBD
cord-262445-54ng7m92	622	5	a	a	DT
cord-262445-54ng7m92	622	6	decrease	decrease	NN
cord-262445-54ng7m92	622	7	of	of	IN
cord-262445-54ng7m92	622	8	SRF	SRF	NNP
cord-262445-54ng7m92	622	9	expression	expression	NN
cord-262445-54ng7m92	622	10	at	at	IN
cord-262445-54ng7m92	622	11	the	the	DT
cord-262445-54ng7m92	622	12	protein	protein	NN
cord-262445-54ng7m92	622	13	level	level	NN
cord-262445-54ng7m92	622	14	in	in	IN
cord-262445-54ng7m92	622	15	cancer	cancer	NN
cord-262445-54ng7m92	622	16	cachexia	cachexia	NN
cord-262445-54ng7m92	622	17	.	.	.
cord-262445-54ng7m92	623	1	Consistently	consistently	RB
cord-262445-54ng7m92	623	2	,	,	,
cord-262445-54ng7m92	623	3	we	-PRON-	PRP
cord-262445-54ng7m92	623	4	showed	show	VBD
cord-262445-54ng7m92	623	5	a	a	DT
cord-262445-54ng7m92	623	6	decrease	decrease	NN
cord-262445-54ng7m92	623	7	in	in	IN
cord-262445-54ng7m92	623	8	the	the	DT
cord-262445-54ng7m92	623	9	expression	expression	NN
cord-262445-54ng7m92	623	10	of	of	IN
cord-262445-54ng7m92	623	11	SRF	SRF	NNP
cord-262445-54ng7m92	623	12	target	target	NN
cord-262445-54ng7m92	623	13	genes	gene	NNS
cord-262445-54ng7m92	623	14	such	such	JJ
cord-262445-54ng7m92	623	15	as	as	IN
cord-262445-54ng7m92	623	16	MyoD	MyoD	NNP
cord-262445-54ng7m92	623	17	and	and	CC
cord-262445-54ng7m92	623	18	SK	SK	NNP
cord-262445-54ng7m92	623	19	-	-	HYPH
cord-262445-54ng7m92	623	20	Actin	Actin	NNP
cord-262445-54ng7m92	623	21	,	,	,
cord-262445-54ng7m92	623	22	which	which	WDT
cord-262445-54ng7m92	623	23	suggest	suggest	VBP
cord-262445-54ng7m92	623	24	a	a	DT
cord-262445-54ng7m92	623	25	decrease	decrease	NN
cord-262445-54ng7m92	623	26	of	of	IN
cord-262445-54ng7m92	623	27	the	the	DT
cord-262445-54ng7m92	623	28	SRF	SRF	NNP
cord-262445-54ng7m92	623	29	transcriptional	transcriptional	JJ
cord-262445-54ng7m92	623	30	activity	activity	NN
cord-262445-54ng7m92	623	31	.	.	.
cord-262445-54ng7m92	624	1	These	these	DT
cord-262445-54ng7m92	624	2	effects	effect	NNS
cord-262445-54ng7m92	624	3	were	be	VBD
cord-262445-54ng7m92	624	4	counteracted	counteract	VBN
cord-262445-54ng7m92	624	5	by	by	IN
cord-262445-54ng7m92	624	6	wheel	wheel	NN
cord-262445-54ng7m92	624	7	running	running	NN
cord-262445-54ng7m92	624	8	.	.	.
cord-262445-54ng7m92	625	1	Since	since	IN
cord-262445-54ng7m92	625	2	we	-PRON-	PRP
cord-262445-54ng7m92	625	3	observed	observe	VBD
cord-262445-54ng7m92	625	4	opposite	opposite	JJ
cord-262445-54ng7m92	625	5	effects	effect	NNS
cord-262445-54ng7m92	625	6	of	of	IN
cord-262445-54ng7m92	625	7	tumor	tumor	NN
cord-262445-54ng7m92	625	8	and	and	CC
cord-262445-54ng7m92	625	9	exercise	exercise	NN
cord-262445-54ng7m92	625	10	on	on	IN
cord-262445-54ng7m92	625	11	MyoD	MyoD	NNP
cord-262445-54ng7m92	625	12	and	and	CC
cord-262445-54ng7m92	625	13	Pax7	Pax7	NNP
cord-262445-54ng7m92	625	14	we	-PRON-	PRP
cord-262445-54ng7m92	625	15	hypothesized	hypothesize	VBD
cord-262445-54ng7m92	625	16	the	the	DT
cord-262445-54ng7m92	625	17	involvement	involvement	NN
cord-262445-54ng7m92	625	18	of	of	IN
cord-262445-54ng7m92	625	19	a	a	DT
cord-262445-54ng7m92	625	20	myogenic	myogenic	NNP
cord-262445-54ng7m92	625	21	program	program	NN
cord-262445-54ng7m92	625	22	in	in	IN
cord-262445-54ng7m92	625	23	stem	stem	NN
cord-262445-54ng7m92	625	24	cell	cell	NN
cord-262445-54ng7m92	625	25	recruitment	recruitment	NN
cord-262445-54ng7m92	625	26	to	to	IN
cord-262445-54ng7m92	625	27	muscle	muscle	NN
cord-262445-54ng7m92	625	28	fibers	fiber	NNS
cord-262445-54ng7m92	625	29	upon	upon	IN
cord-262445-54ng7m92	625	30	exercise	exercise	NN
cord-262445-54ng7m92	625	31	:	:	:
cord-262445-54ng7m92	625	32	indeed	indeed	RB
cord-262445-54ng7m92	625	33	,	,	,
cord-262445-54ng7m92	625	34	we	-PRON-	PRP
cord-262445-54ng7m92	625	35	observed	observe	VBD
cord-262445-54ng7m92	625	36	the	the	DT
cord-262445-54ng7m92	625	37	recruitment	recruitment	NN
cord-262445-54ng7m92	625	38	of	of	IN
cord-262445-54ng7m92	625	39	nuclei	nucleus	NNS
cord-262445-54ng7m92	625	40	within	within	IN
cord-262445-54ng7m92	625	41	the	the	DT
cord-262445-54ng7m92	625	42	muscle	muscle	NN
cord-262445-54ng7m92	625	43	fibers	fiber	NNS
cord-262445-54ng7m92	625	44	in	in	IN
cord-262445-54ng7m92	625	45	response	response	NN
cord-262445-54ng7m92	625	46	to	to	TO
cord-262445-54ng7m92	625	47	exercise	exercise	VB
cord-262445-54ng7m92	625	48	,	,	,
cord-262445-54ng7m92	625	49	which	which	WDT
cord-262445-54ng7m92	625	50	could	could	MD
cord-262445-54ng7m92	625	51	contribute	contribute	VB
cord-262445-54ng7m92	625	52	to	to	IN
cord-262445-54ng7m92	625	53	muscle	muscle	NN
cord-262445-54ng7m92	625	54	homeostasis	homeostasis	NN
cord-262445-54ng7m92	625	55	.	.	.
cord-262445-54ng7m92	626	1	Our	-PRON-	PRP$
cord-262445-54ng7m92	626	2	preliminary	preliminary	JJ
cord-262445-54ng7m92	626	3	results	result	NNS
cord-262445-54ng7m92	626	4	suggest	suggest	VBP
cord-262445-54ng7m92	626	5	that	that	IN
cord-262445-54ng7m92	626	6	physical	physical	JJ
cord-262445-54ng7m92	626	7	activity	activity	NN
cord-262445-54ng7m92	626	8	rescues	rescue	VBZ
cord-262445-54ng7m92	626	9	SRF	SRF	NNP
cord-262445-54ng7m92	626	10	expression	expression	NN
cord-262445-54ng7m92	626	11	as	as	RB
cord-262445-54ng7m92	626	12	well	well	RB
cord-262445-54ng7m92	626	13	as	as	IN
cord-262445-54ng7m92	626	14	its	-PRON-	PRP$
cord-262445-54ng7m92	626	15	transcriptional	transcriptional	JJ
cord-262445-54ng7m92	626	16	activity	activity	NN
cord-262445-54ng7m92	626	17	,	,	,
cord-262445-54ng7m92	626	18	highlighting	highlight	VBG
cord-262445-54ng7m92	626	19	the	the	DT
cord-262445-54ng7m92	626	20	importance	importance	NN
cord-262445-54ng7m92	626	21	of	of	IN
cord-262445-54ng7m92	626	22	genetic	genetic	JJ
cord-262445-54ng7m92	626	23	activation	activation	NN
cord-262445-54ng7m92	626	24	induced	induce	VBN
cord-262445-54ng7m92	626	25	by	by	IN
cord-262445-54ng7m92	626	26	skeletal	skeletal	JJ
cord-262445-54ng7m92	626	27	muscle	muscle	NN
cord-262445-54ng7m92	626	28	activity	activity	NN
cord-262445-54ng7m92	626	29	for	for	IN
cord-262445-54ng7m92	626	30	muscle	muscle	NN
cord-262445-54ng7m92	626	31	rescue	rescue	NN
cord-262445-54ng7m92	626	32	and	and	CC
cord-262445-54ng7m92	626	33	homeostasis	homeostasis	NN
cord-262445-54ng7m92	626	34	.	.	.
cord-262445-54ng7m92	627	1	These	these	DT
cord-262445-54ng7m92	627	2	effects	effect	NNS
cord-262445-54ng7m92	627	3	could	could	MD
cord-262445-54ng7m92	627	4	be	be	VB
cord-262445-54ng7m92	627	5	extended	extend	VBN
cord-262445-54ng7m92	627	6	to	to	IN
cord-262445-54ng7m92	627	7	the	the	DT
cord-262445-54ng7m92	627	8	fiber	fiber	NN
cord-262445-54ng7m92	627	9	microenvironment	microenvironment	NN
cord-262445-54ng7m92	627	10	,	,	,
cord-262445-54ng7m92	627	11	including	include	VBG
cord-262445-54ng7m92	627	12	myogenic	myogenic	NNP
cord-262445-54ng7m92	627	13	stem	stem	NN
cord-262445-54ng7m92	627	14	cell	cell	NN
cord-262445-54ng7m92	627	15	activity	activity	NN
cord-262445-54ng7m92	627	16	.	.	.
cord-262445-54ng7m92	628	1	Vitamin	vitamin	NN
cord-262445-54ng7m92	628	2	(	(	-LRB-
cord-262445-54ng7m92	628	3	Vit	Vit	NNP
cord-262445-54ng7m92	628	4	)	)	-RRB-
cord-262445-54ng7m92	628	5	D	D	NNP
cord-262445-54ng7m92	628	6	is	be	VBZ
cord-262445-54ng7m92	628	7	a	a	DT
cord-262445-54ng7m92	628	8	pleiotropic	pleiotropic	JJ
cord-262445-54ng7m92	628	9	hormone	hormone	NN
cord-262445-54ng7m92	628	10	synthesized	synthesize	VBN
cord-262445-54ng7m92	628	11	mainly	mainly	RB
cord-262445-54ng7m92	628	12	in	in	IN
cord-262445-54ng7m92	628	13	the	the	DT
cord-262445-54ng7m92	628	14	skin	skin	NN
cord-262445-54ng7m92	628	15	via	via	IN
cord-262445-54ng7m92	628	16	a	a	DT
cord-262445-54ng7m92	628	17	UV	uv	NN
cord-262445-54ng7m92	628	18	-	-	HYPH
cord-262445-54ng7m92	628	19	dependent	dependent	JJ
cord-262445-54ng7m92	628	20	reaction	reaction	NN
cord-262445-54ng7m92	628	21	.	.	.
cord-262445-54ng7m92	629	1	VitD	VitD	NNP
cord-262445-54ng7m92	629	2	circulates	circulate	VBZ
cord-262445-54ng7m92	629	3	in	in	IN
cord-262445-54ng7m92	629	4	the	the	DT
cord-262445-54ng7m92	629	5	blood	blood	NN
cord-262445-54ng7m92	629	6	bound	bind	VBN
cord-262445-54ng7m92	629	7	to	to	IN
cord-262445-54ng7m92	629	8	vitamin	vitamin	NN
cord-262445-54ng7m92	629	9	D	d	NN
cord-262445-54ng7m92	629	10	-	-	HYPH
cord-262445-54ng7m92	629	11	binding	bind	VBG
cord-262445-54ng7m92	629	12	proteins	protein	NNS
cord-262445-54ng7m92	629	13	,	,	,
cord-262445-54ng7m92	629	14	reaching	reach	VBG
cord-262445-54ng7m92	629	15	its	-PRON-	PRP$
cord-262445-54ng7m92	629	16	target	target	NN
cord-262445-54ng7m92	629	17	tissues	tissue	NNS
cord-262445-54ng7m92	629	18	,	,	,
cord-262445-54ng7m92	629	19	where	where	WRB
cord-262445-54ng7m92	629	20	exerts	exert	VBZ
cord-262445-54ng7m92	629	21	its	-PRON-	PRP$
cord-262445-54ng7m92	629	22	endocrine	endocrine	JJ
cord-262445-54ng7m92	629	23	actions	action	NNS
cord-262445-54ng7m92	629	24	through	through	IN
cord-262445-54ng7m92	629	25	the	the	DT
cord-262445-54ng7m92	629	26	VitD3	VitD3	NNP
cord-262445-54ng7m92	629	27	receptor	receptor	NN
cord-262445-54ng7m92	629	28	(	(	-LRB-
cord-262445-54ng7m92	629	29	VDR	VDR	NNP
cord-262445-54ng7m92	629	30	)	)	-RRB-
cord-262445-54ng7m92	629	31	,	,	,
cord-262445-54ng7m92	629	32	a	a	DT
cord-262445-54ng7m92	629	33	member	member	NN
cord-262445-54ng7m92	629	34	of	of	IN
cord-262445-54ng7m92	629	35	the	the	DT
cord-262445-54ng7m92	629	36	nuclear	nuclear	JJ
cord-262445-54ng7m92	629	37	receptor	receptor	NN
cord-262445-54ng7m92	629	38	family	family	NN
cord-262445-54ng7m92	629	39	expressed	express	VBN
cord-262445-54ng7m92	629	40	in	in	IN
cord-262445-54ng7m92	629	41	different	different	JJ
cord-262445-54ng7m92	629	42	tissues	tissue	NNS
cord-262445-54ng7m92	629	43	,	,	,
cord-262445-54ng7m92	629	44	including	include	VBG
cord-262445-54ng7m92	629	45	skeletal	skeletal	JJ
cord-262445-54ng7m92	629	46	muscle	muscle	NN
cord-262445-54ng7m92	629	47	.	.	.
cord-262445-54ng7m92	630	1	Some	some	DT
cord-262445-54ng7m92	630	2	VitD	VitD	NNP
cord-262445-54ng7m92	630	3	actions	action	NNS
cord-262445-54ng7m92	630	4	have	have	VBP
cord-262445-54ng7m92	630	5	been	be	VBN
cord-262445-54ng7m92	630	6	shown	show	VBN
cord-262445-54ng7m92	630	7	to	to	TO
cord-262445-54ng7m92	630	8	be	be	VB
cord-262445-54ng7m92	630	9	at	at	IN
cord-262445-54ng7m92	630	10	long	long	JJ
cord-262445-54ng7m92	630	11	term	term	NN
cord-262445-54ng7m92	630	12	and	and	CC
cord-262445-54ng7m92	630	13	others	other	NNS
cord-262445-54ng7m92	630	14	at	at	IN
cord-262445-54ng7m92	630	15	more	more	RBR
cord-262445-54ng7m92	630	16	immediate	immediate	JJ
cord-262445-54ng7m92	630	17	term	term	NN
cord-262445-54ng7m92	630	18	,	,	,
cord-262445-54ng7m92	630	19	suggesting	suggest	VBG
cord-262445-54ng7m92	630	20	the	the	DT
cord-262445-54ng7m92	630	21	engagement	engagement	NN
cord-262445-54ng7m92	630	22	of	of	IN
cord-262445-54ng7m92	630	23	nuclear	nuclear	JJ
cord-262445-54ng7m92	630	24	VDR	VDR	NNP
cord-262445-54ng7m92	630	25	for	for	IN
cord-262445-54ng7m92	630	26	gene	gene	NN
cord-262445-54ng7m92	630	27	expression	expression	NN
cord-262445-54ng7m92	630	28	regulation	regulation	NN
cord-262445-54ng7m92	630	29	and	and	CC
cord-262445-54ng7m92	630	30	of	of	IN
cord-262445-54ng7m92	630	31	membrane	membrane	NN
cord-262445-54ng7m92	630	32	-	-	HYPH
cord-262445-54ng7m92	630	33	associated	associate	VBN
cord-262445-54ng7m92	630	34	VDR	VDR	NNP
cord-262445-54ng7m92	630	35	for	for	IN
cord-262445-54ng7m92	630	36	the	the	DT
cord-262445-54ng7m92	630	37	control	control	NN
cord-262445-54ng7m92	630	38	of	of	IN
cord-262445-54ng7m92	630	39	specific	specific	JJ
cord-262445-54ng7m92	630	40	signalling	signal	VBG
cord-262445-54ng7m92	630	41	pathways	pathway	NNS
cord-262445-54ng7m92	630	42	.	.	.
cord-262445-54ng7m92	631	1	VitD	VitD	NNP
cord-262445-54ng7m92	631	2	deficiency	deficiency	NN
cord-262445-54ng7m92	631	3	has	have	VBZ
cord-262445-54ng7m92	631	4	been	be	VBN
cord-262445-54ng7m92	631	5	shown	show	VBN
cord-262445-54ng7m92	631	6	to	to	TO
cord-262445-54ng7m92	631	7	cause	cause	VB
cord-262445-54ng7m92	631	8	abnormalities	abnormality	NNS
cord-262445-54ng7m92	631	9	in	in	IN
cord-262445-54ng7m92	631	10	skeletal	skeletal	JJ
cord-262445-54ng7m92	631	11	muscle	muscle	NN
cord-262445-54ng7m92	631	12	,	,	,
cord-262445-54ng7m92	631	13	such	such	JJ
cord-262445-54ng7m92	631	14	as	as	IN
cord-262445-54ng7m92	631	15	reduced	reduce	VBN
cord-262445-54ng7m92	631	16	actomyosin	actomyosin	NNS
cord-262445-54ng7m92	631	17	content	content	NN
cord-262445-54ng7m92	631	18	and	and	CC
cord-262445-54ng7m92	631	19	decrease	decrease	NN
cord-262445-54ng7m92	631	20	in	in	IN
cord-262445-54ng7m92	631	21	mitochondrial	mitochondrial	NN
cord-262445-54ng7m92	632	1	Ca	ca	NN
cord-262445-54ng7m92	632	2	2	2	CD
cord-262445-54ng7m92	632	3	+	+	SYM
cord-262445-54ng7m92	632	4	levels	level	NNS
cord-262445-54ng7m92	632	5	.	.	.
cord-262445-54ng7m92	633	1	Moreover	moreover	RB
cord-262445-54ng7m92	633	2	,	,	,
cord-262445-54ng7m92	633	3	in	in	IN
cord-262445-54ng7m92	633	4	vitro	vitro	FW
cord-262445-54ng7m92	633	5	experiments	experiment	NNS
cord-262445-54ng7m92	633	6	suggest	suggest	VBP
cord-262445-54ng7m92	633	7	that	that	IN
cord-262445-54ng7m92	633	8	VDR	VDR	NNP
cord-262445-54ng7m92	633	9	is	be	VBZ
cord-262445-54ng7m92	633	10	likely	likely	JJ
cord-262445-54ng7m92	633	11	to	to	TO
cord-262445-54ng7m92	633	12	play	play	VB
cord-262445-54ng7m92	633	13	an	an	DT
cord-262445-54ng7m92	633	14	important	important	JJ
cord-262445-54ng7m92	633	15	role	role	NN
cord-262445-54ng7m92	633	16	during	during	IN
cord-262445-54ng7m92	633	17	myoblast	myoblast	NN
cord-262445-54ng7m92	633	18	differentiation	differentiation	NN
cord-262445-54ng7m92	633	19	,	,	,
cord-262445-54ng7m92	633	20	regulating	regulate	VBG
cord-262445-54ng7m92	633	21	the	the	DT
cord-262445-54ng7m92	633	22	expression	expression	NN
cord-262445-54ng7m92	633	23	of	of	IN
cord-262445-54ng7m92	633	24	myogenin	myogenin	NNP
cord-262445-54ng7m92	633	25	.	.	.
cord-262445-54ng7m92	634	1	Despite	despite	IN
cord-262445-54ng7m92	634	2	several	several	JJ
cord-262445-54ng7m92	634	3	evidence	evidence	NN
cord-262445-54ng7m92	634	4	demonstrating	demonstrate	VBG
cord-262445-54ng7m92	634	5	a	a	DT
cord-262445-54ng7m92	634	6	protective	protective	JJ
cord-262445-54ng7m92	634	7	role	role	NN
cord-262445-54ng7m92	634	8	of	of	IN
cord-262445-54ng7m92	634	9	VitD	VitD	NNP
cord-262445-54ng7m92	634	10	in	in	IN
cord-262445-54ng7m92	634	11	skeletal	skeletal	JJ
cord-262445-54ng7m92	634	12	muscle	muscle	NN
cord-262445-54ng7m92	634	13	cells	cell	NNS
cord-262445-54ng7m92	634	14	,	,	,
cord-262445-54ng7m92	634	15	the	the	DT
cord-262445-54ng7m92	634	16	characterization	characterization	NN
cord-262445-54ng7m92	634	17	of	of	IN
cord-262445-54ng7m92	634	18	biomolecules	biomolecule	NNS
cord-262445-54ng7m92	634	19	that	that	WDT
cord-262445-54ng7m92	634	20	positively	positively	RB
cord-262445-54ng7m92	634	21	affect	affect	VBP
cord-262445-54ng7m92	634	22	VDR	VDR	NNP
cord-262445-54ng7m92	634	23	expression	expression	NN
cord-262445-54ng7m92	634	24	/function	/function	.
cord-262445-54ng7m92	634	25	are	be	VBP
cord-262445-54ng7m92	634	26	limited	limit	VBN
cord-262445-54ng7m92	634	27	.	.	.
cord-262445-54ng7m92	635	1	In	in	IN
cord-262445-54ng7m92	635	2	the	the	DT
cord-262445-54ng7m92	635	3	present	present	JJ
cord-262445-54ng7m92	635	4	study	study	NN
cord-262445-54ng7m92	635	5	we	-PRON-	PRP
cord-262445-54ng7m92	635	6	investigate	investigate	VBP
cord-262445-54ng7m92	635	7	the	the	DT
cord-262445-54ng7m92	635	8	role	role	NN
cord-262445-54ng7m92	635	9	of	of	IN
cord-262445-54ng7m92	635	10	sphingolipids	sphingolipid	NNS
cord-262445-54ng7m92	635	11	in	in	IN
cord-262445-54ng7m92	635	12	the	the	DT
cord-262445-54ng7m92	635	13	regulation	regulation	NN
cord-262445-54ng7m92	635	14	of	of	IN
cord-262445-54ng7m92	635	15	VDR	VDR	NNP
cord-262445-54ng7m92	635	16	expression	expression	NN
cord-262445-54ng7m92	635	17	in	in	IN
cord-262445-54ng7m92	635	18	C2C12	c2c12	JJ
cord-262445-54ng7m92	635	19	myoblasts	myoblasts	NNP
cord-262445-54ng7m92	635	20	/	/	SYM
cord-262445-54ng7m92	635	21	myotubes	myotube	NNS
cord-262445-54ng7m92	635	22	and	and	CC
cord-262445-54ng7m92	635	23	the	the	DT
cord-262445-54ng7m92	635	24	molecular	molecular	JJ
cord-262445-54ng7m92	635	25	mechanisms	mechanism	NNS
cord-262445-54ng7m92	635	26	by	by	IN
cord-262445-54ng7m92	635	27	which	which	WDT
cord-262445-54ng7m92	635	28	SLs	SLs	NNP
cord-262445-54ng7m92	635	29	metabolites	metabolite	NNS
cord-262445-54ng7m92	635	30	,	,	,
cord-262445-54ng7m92	635	31	in	in	IN
cord-262445-54ng7m92	635	32	particular	particular	JJ
cord-262445-54ng7m92	635	33	Sphingosine-1-phosphate	Sphingosine-1-phosphate	NNP
cord-262445-54ng7m92	635	34	,	,	,
cord-262445-54ng7m92	635	35	determine	determine	VB
cord-262445-54ng7m92	635	36	an	an	DT
cord-262445-54ng7m92	635	37	increase	increase	NN
cord-262445-54ng7m92	635	38	in	in	IN
cord-262445-54ng7m92	635	39	VDR	VDR	NNP
cord-262445-54ng7m92	635	40	expression	expression	NN
cord-262445-54ng7m92	635	41	in	in	IN
cord-262445-54ng7m92	635	42	skeletal	skeletal	JJ
cord-262445-54ng7m92	635	43	muscle	muscle	NN
cord-262445-54ng7m92	635	44	cells	cell	NNS
cord-262445-54ng7m92	635	45	.	.	.
cord-262445-54ng7m92	636	1	Oxidative	oxidative	JJ
cord-262445-54ng7m92	636	2	stress	stress	NN
cord-262445-54ng7m92	636	3	and	and	CC
cord-262445-54ng7m92	636	4	chronic	chronic	JJ
cord-262445-54ng7m92	636	5	inflammation	inflammation	NN
cord-262445-54ng7m92	636	6	have	have	VBP
cord-262445-54ng7m92	636	7	been	be	VBN
cord-262445-54ng7m92	636	8	proposed	propose	VBN
cord-262445-54ng7m92	636	9	as	as	IN
cord-262445-54ng7m92	636	10	important	important	JJ
cord-262445-54ng7m92	636	11	interconnected	interconnect	VBN
cord-262445-54ng7m92	636	12	mechanisms	mechanism	NNS
cord-262445-54ng7m92	636	13	affecting	affect	VBG
cord-262445-54ng7m92	636	14	skeletal	skeletal	JJ
cord-262445-54ng7m92	636	15	muscle	muscle	NN
cord-262445-54ng7m92	636	16	homeostasis	homeostasis	NN
cord-262445-54ng7m92	636	17	under	under	IN
cord-262445-54ng7m92	636	18	pathologic	pathologic	JJ
cord-262445-54ng7m92	636	19	conditions	condition	NNS
cord-262445-54ng7m92	636	20	,	,	,
cord-262445-54ng7m92	636	21	being	be	VBG
cord-262445-54ng7m92	636	22	mutually	mutually	RB
cord-262445-54ng7m92	636	23	induced	induce	VBN
cord-262445-54ng7m92	636	24	processes	process	NNS
cord-262445-54ng7m92	636	25	.	.	.
cord-262445-54ng7m92	637	1	Although	although	IN
cord-262445-54ng7m92	637	2	reactive	reactive	JJ
cord-262445-54ng7m92	637	3	species	specie	NNS
cord-262445-54ng7m92	637	4	are	be	VBP
cord-262445-54ng7m92	637	5	physiologically	physiologically	RB
cord-262445-54ng7m92	637	6	formed	form	VBN
cord-262445-54ng7m92	637	7	inside	inside	RB
cord-262445-54ng7m92	637	8	of	of	IN
cord-262445-54ng7m92	637	9	skeletal	skeletal	JJ
cord-262445-54ng7m92	637	10	muscle	muscle	NN
cord-262445-54ng7m92	637	11	by	by	IN
cord-262445-54ng7m92	637	12	inflammatory	inflammatory	JJ
cord-262445-54ng7m92	637	13	cells	cell	NNS
cord-262445-54ng7m92	637	14	as	as	RB
cord-262445-54ng7m92	637	15	well	well	RB
cord-262445-54ng7m92	637	16	as	as	IN
cord-262445-54ng7m92	637	17	myofibers	myofiber	NNS
cord-262445-54ng7m92	637	18	,	,	,
cord-262445-54ng7m92	637	19	the	the	DT
cord-262445-54ng7m92	637	20	endogenous	endogenous	JJ
cord-262445-54ng7m92	637	21	antioxidant	antioxidant	NN
cord-262445-54ng7m92	637	22	defense	defense	NN
cord-262445-54ng7m92	637	23	is	be	VBZ
cord-262445-54ng7m92	637	24	able	able	JJ
cord-262445-54ng7m92	637	25	to	to	TO
cord-262445-54ng7m92	637	26	maintain	maintain	VB
cord-262445-54ng7m92	637	27	reactive	reactive	JJ
cord-262445-54ng7m92	637	28	radicals	radical	NNS
cord-262445-54ng7m92	637	29	at	at	IN
cord-262445-54ng7m92	637	30	functional	functional	JJ
cord-262445-54ng7m92	637	31	levels	level	NNS
cord-262445-54ng7m92	637	32	.	.	.
cord-262445-54ng7m92	638	1	Instead	instead	RB
cord-262445-54ng7m92	638	2	,	,	,
cord-262445-54ng7m92	638	3	under	under	IN
cord-262445-54ng7m92	638	4	pathological	pathological	JJ
cord-262445-54ng7m92	638	5	conditions	condition	NNS
cord-262445-54ng7m92	638	6	the	the	DT
cord-262445-54ng7m92	638	7	excess	excess	NN
cord-262445-54ng7m92	638	8	of	of	IN
cord-262445-54ng7m92	638	9	reactive	reactive	JJ
cord-262445-54ng7m92	638	10	species	specie	NNS
cord-262445-54ng7m92	638	11	can	can	MD
cord-262445-54ng7m92	638	12	overwhelm	overwhelm	VB
cord-262445-54ng7m92	638	13	antioxidant	antioxidant	JJ
cord-262445-54ng7m92	638	14	defense	defense	NN
cord-262445-54ng7m92	638	15	leading	lead	VBG
cord-262445-54ng7m92	638	16	to	to	IN
cord-262445-54ng7m92	638	17	oxidative	oxidative	JJ
cord-262445-54ng7m92	638	18	damages	damage	NNS
cord-262445-54ng7m92	638	19	and	and	CC
cord-262445-54ng7m92	638	20	to	to	IN
cord-262445-54ng7m92	638	21	the	the	DT
cord-262445-54ng7m92	638	22	activation	activation	NN
cord-262445-54ng7m92	638	23	of	of	IN
cord-262445-54ng7m92	638	24	pro	pro	JJ
cord-262445-54ng7m92	638	25	-	-	JJ
cord-262445-54ng7m92	638	26	inflammatory	inflammatory	JJ
cord-262445-54ng7m92	638	27	pathways	pathway	NNS
cord-262445-54ng7m92	638	28	.	.	.
cord-262445-54ng7m92	639	1	On	on	IN
cord-262445-54ng7m92	639	2	the	the	DT
cord-262445-54ng7m92	639	3	other	other	JJ
cord-262445-54ng7m92	639	4	hand	hand	NN
cord-262445-54ng7m92	639	5	,	,	,
cord-262445-54ng7m92	639	6	inflammatory	inflammatory	JJ
cord-262445-54ng7m92	639	7	response	response	NN
cord-262445-54ng7m92	639	8	is	be	VBZ
cord-262445-54ng7m92	639	9	considered	consider	VBN
cord-262445-54ng7m92	639	10	one	one	CD
cord-262445-54ng7m92	639	11	of	of	IN
cord-262445-54ng7m92	639	12	the	the	DT
cord-262445-54ng7m92	639	13	principal	principal	JJ
cord-262445-54ng7m92	639	14	determinants	determinant	NNS
cord-262445-54ng7m92	639	15	of	of	IN
cord-262445-54ng7m92	639	16	degenerative	degenerative	JJ
cord-262445-54ng7m92	639	17	processes	process	NNS
cord-262445-54ng7m92	639	18	in	in	IN
cord-262445-54ng7m92	639	19	degenerative	degenerative	JJ
cord-262445-54ng7m92	639	20	disorders	disorder	NNS
cord-262445-54ng7m92	639	21	.	.	.
cord-262445-54ng7m92	640	1	However	however	RB
cord-262445-54ng7m92	640	2	,	,	,
cord-262445-54ng7m92	640	3	the	the	DT
cord-262445-54ng7m92	640	4	clear	clear	JJ
cord-262445-54ng7m92	640	5	connection	connection	NN
cord-262445-54ng7m92	640	6	between	between	IN
cord-262445-54ng7m92	640	7	the	the	DT
cord-262445-54ng7m92	640	8	extent	extent	NN
cord-262445-54ng7m92	640	9	of	of	IN
cord-262445-54ng7m92	640	10	oxidative	oxidative	JJ
cord-262445-54ng7m92	640	11	stress	stress	NN
cord-262445-54ng7m92	640	12	and	and	CC
cord-262445-54ng7m92	640	13	inflammation	inflammation	NN
cord-262445-54ng7m92	640	14	has	have	VBZ
cord-262445-54ng7m92	640	15	still	still	RB
cord-262445-54ng7m92	640	16	to	to	TO
cord-262445-54ng7m92	640	17	be	be	VB
cord-262445-54ng7m92	640	18	understood	understand	VBN
cord-262445-54ng7m92	640	19	.	.	.
cord-262445-54ng7m92	641	1	Hence	hence	RB
cord-262445-54ng7m92	641	2	the	the	DT
cord-262445-54ng7m92	641	3	needs	need	NNS
cord-262445-54ng7m92	641	4	of	of	IN
cord-262445-54ng7m92	641	5	identifying	identify	VBG
cord-262445-54ng7m92	641	6	and	and	CC
cord-262445-54ng7m92	641	7	studying	study	VBG
cord-262445-54ng7m92	641	8	key	key	JJ
cord-262445-54ng7m92	641	9	factors	factor	NNS
cord-262445-54ng7m92	641	10	involved	involve	VBN
cord-262445-54ng7m92	641	11	in	in	IN
cord-262445-54ng7m92	641	12	the	the	DT
cord-262445-54ng7m92	641	13	intimate	intimate	JJ
cord-262445-54ng7m92	641	14	relation	relation	NN
cord-262445-54ng7m92	641	15	between	between	IN
cord-262445-54ng7m92	641	16	these	these	DT
cord-262445-54ng7m92	641	17	two	two	CD
cord-262445-54ng7m92	641	18	important	important	JJ
cord-262445-54ng7m92	641	19	pathogenic	pathogenic	JJ
cord-262445-54ng7m92	641	20	mechanisms	mechanism	NNS
cord-262445-54ng7m92	641	21	that	that	WDT
cord-262445-54ng7m92	641	22	might	may	MD
cord-262445-54ng7m92	641	23	allow	allow	VB
cord-262445-54ng7m92	641	24	relevant	relevant	JJ
cord-262445-54ng7m92	641	25	advances	advance	NNS
cord-262445-54ng7m92	641	26	in	in	IN
cord-262445-54ng7m92	641	27	the	the	DT
cord-262445-54ng7m92	641	28	field	field	NN
cord-262445-54ng7m92	641	29	of	of	IN
cord-262445-54ng7m92	641	30	chronic	chronic	JJ
cord-262445-54ng7m92	641	31	diseases	disease	NNS
cord-262445-54ng7m92	641	32	.	.	.
cord-262445-54ng7m92	642	1	Among	among	IN
cord-262445-54ng7m92	642	2	factors	factor	NNS
cord-262445-54ng7m92	642	3	playing	play	VBG
cord-262445-54ng7m92	642	4	a	a	DT
cord-262445-54ng7m92	642	5	critical	critical	JJ
cord-262445-54ng7m92	642	6	role	role	NN
cord-262445-54ng7m92	642	7	in	in	IN
cord-262445-54ng7m92	642	8	skeletal	skeletal	JJ
cord-262445-54ng7m92	642	9	muscle	muscle	NN
cord-262445-54ng7m92	642	10	physiopathology	physiopathology	NN
cord-262445-54ng7m92	642	11	Interleukin-6	Interleukin-6	NNP
cord-262445-54ng7m92	642	12	(	(	-LRB-
cord-262445-54ng7m92	642	13	IL-6	IL-6	NNP
cord-262445-54ng7m92	642	14	)	)	-RRB-
cord-262445-54ng7m92	642	15	is	be	VBZ
cord-262445-54ng7m92	642	16	an	an	DT
cord-262445-54ng7m92	642	17	elective	elective	JJ
cord-262445-54ng7m92	642	18	candidate	candidate	NN
cord-262445-54ng7m92	642	19	.	.	.
cord-262445-54ng7m92	643	1	Here	here	RB
cord-262445-54ng7m92	643	2	we	-PRON-	PRP
cord-262445-54ng7m92	643	3	reported	report	VBD
cord-262445-54ng7m92	643	4	that	that	IN
cord-262445-54ng7m92	643	5	increased	increase	VBN
cord-262445-54ng7m92	643	6	levels	level	NNS
cord-262445-54ng7m92	643	7	of	of	IN
cord-262445-54ng7m92	643	8	circulating	circulate	VBG
cord-262445-54ng7m92	643	9	IL-6	IL-6	NNP
cord-262445-54ng7m92	643	10	are	be	VBP
cord-262445-54ng7m92	643	11	sufficient	sufficient	JJ
cord-262445-54ng7m92	643	12	to	to	TO
cord-262445-54ng7m92	643	13	alter	alter	VB
cord-262445-54ng7m92	643	14	the	the	DT
cord-262445-54ng7m92	643	15	physiologic	physiologic	JJ
cord-262445-54ng7m92	643	16	redox	redox	NN
cord-262445-54ng7m92	643	17	balance	balance	NN
cord-262445-54ng7m92	643	18	of	of	IN
cord-262445-54ng7m92	643	19	skeletal	skeletal	JJ
cord-262445-54ng7m92	643	20	muscle	muscle	NN
cord-262445-54ng7m92	643	21	tissue	tissue	NN
cord-262445-54ng7m92	643	22	and	and	CC
cord-262445-54ng7m92	643	23	to	to	TO
cord-262445-54ng7m92	643	24	induce	induce	VB
cord-262445-54ng7m92	643	25	the	the	DT
cord-262445-54ng7m92	643	26	establishment	establishment	NN
cord-262445-54ng7m92	643	27	of	of	IN
cord-262445-54ng7m92	643	28	an	an	DT
cord-262445-54ng7m92	643	29	inflammatory	inflammatory	JJ
cord-262445-54ng7m92	643	30	milieu	milieu	NN
cord-262445-54ng7m92	643	31	.	.	.
cord-262445-54ng7m92	644	1	We	-PRON-	PRP
cord-262445-54ng7m92	644	2	revealed	reveal	VBD
cord-262445-54ng7m92	644	3	that	that	IN
cord-262445-54ng7m92	644	4	high	high	JJ
cord-262445-54ng7m92	644	5	levels	level	NNS
cord-262445-54ng7m92	644	6	of	of	IN
cord-262445-54ng7m92	644	7	IL-6	IL-6	NNP
cord-262445-54ng7m92	644	8	in	in	IN
cord-262445-54ng7m92	644	9	the	the	DT
cord-262445-54ng7m92	644	10	bloodstream	bloodstream	NN
cord-262445-54ng7m92	644	11	enhance	enhance	VBP
cord-262445-54ng7m92	644	12	the	the	DT
cord-262445-54ng7m92	644	13	production	production	NN
cord-262445-54ng7m92	644	14	and	and	CC
cord-262445-54ng7m92	644	15	accumulation	accumulation	NN
cord-262445-54ng7m92	644	16	of	of	IN
cord-262445-54ng7m92	644	17	reactive	reactive	JJ
cord-262445-54ng7m92	644	18	species	specie	NNS
cord-262445-54ng7m92	644	19	in	in	IN
cord-262445-54ng7m92	644	20	diaphragm	diaphragm	NN
cord-262445-54ng7m92	644	21	muscles	muscle	NNS
cord-262445-54ng7m92	644	22	of	of	IN
cord-262445-54ng7m92	644	23	adult	adult	NN
cord-262445-54ng7m92	644	24	NSE	NSE	NNP
cord-262445-54ng7m92	644	25	/	/	SYM
cord-262445-54ng7m92	644	26	IL-6	IL-6	NNP
cord-262445-54ng7m92	644	27	mice	mouse	NNS
cord-262445-54ng7m92	644	28	,	,	,
cord-262445-54ng7m92	644	29	by	by	IN
cord-262445-54ng7m92	644	30	impinging	impinge	VBG
cord-262445-54ng7m92	644	31	the	the	DT
cord-262445-54ng7m92	644	32	muscle	muscle	NN
cord-262445-54ng7m92	644	33	redox	redox	NN
cord-262445-54ng7m92	644	34	balance	balance	NN
cord-262445-54ng7m92	644	35	and	and	CC
cord-262445-54ng7m92	644	36	impairing	impair	VBG
cord-262445-54ng7m92	644	37	the	the	DT
cord-262445-54ng7m92	644	38	Nrf2-mediated	nrf2-mediated	JJ
cord-262445-54ng7m92	644	39	antioxidant	antioxidant	JJ
cord-262445-54ng7m92	644	40	response	response	NN
cord-262445-54ng7m92	644	41	.	.	.
cord-262445-54ng7m92	645	1	In	in	IN
cord-262445-54ng7m92	645	2	addition	addition	NN
cord-262445-54ng7m92	645	3	,	,	,
cord-262445-54ng7m92	645	4	the	the	DT
cord-262445-54ng7m92	645	5	occurrence	occurrence	NN
cord-262445-54ng7m92	645	6	of	of	IN
cord-262445-54ng7m92	645	7	pro	pro	JJ
cord-262445-54ng7m92	645	8	-	-	JJ
cord-262445-54ng7m92	645	9	oxidant	oxidant	JJ
cord-262445-54ng7m92	645	10	conditions	condition	NNS
cord-262445-54ng7m92	645	11	in	in	IN
cord-262445-54ng7m92	645	12	muscles	muscle	NNS
cord-262445-54ng7m92	645	13	exposed	expose	VBN
cord-262445-54ng7m92	645	14	to	to	IN
cord-262445-54ng7m92	645	15	abnormal	abnormal	JJ
cord-262445-54ng7m92	645	16	amounts	amount	NNS
cord-262445-54ng7m92	645	17	of	of	IN
cord-262445-54ng7m92	645	18	IL-6	IL-6	NNP
cord-262445-54ng7m92	645	19	stimulates	stimulate	VBZ
cord-262445-54ng7m92	645	20	the	the	DT
cord-262445-54ng7m92	645	21	establishment	establishment	NN
cord-262445-54ng7m92	645	22	of	of	IN
cord-262445-54ng7m92	645	23	a	a	DT
cord-262445-54ng7m92	645	24	delicate	delicate	JJ
cord-262445-54ng7m92	645	25	inflammatory	inflammatory	JJ
cord-262445-54ng7m92	645	26	balance	balance	NN
cord-262445-54ng7m92	645	27	within	within	IN
cord-262445-54ng7m92	645	28	muscle	muscle	NN
cord-262445-54ng7m92	645	29	environment	environment	NN
cord-262445-54ng7m92	645	30	,	,	,
cord-262445-54ng7m92	645	31	characterized	characterize	VBN
cord-262445-54ng7m92	645	32	by	by	IN
cord-262445-54ng7m92	645	33	the	the	DT
cord-262445-54ng7m92	645	34	induction	induction	NN
cord-262445-54ng7m92	645	35	of	of	IN
cord-262445-54ng7m92	645	36	pro	pro	JJ
cord-262445-54ng7m92	645	37	-	-	JJ
cord-262445-54ng7m92	645	38	inflammatory	inflammatory	JJ
cord-262445-54ng7m92	645	39	mediators	mediator	NNS
cord-262445-54ng7m92	645	40	.	.	.
cord-262445-54ng7m92	646	1	Thus	thus	RB
cord-262445-54ng7m92	646	2	,	,	,
cord-262445-54ng7m92	646	3	uncontrolled	uncontrolled	JJ
cord-262445-54ng7m92	646	4	levels	level	NNS
cord-262445-54ng7m92	646	5	of	of	IN
cord-262445-54ng7m92	646	6	this	this	DT
cord-262445-54ng7m92	646	7	cytokine	cytokine	NN
cord-262445-54ng7m92	646	8	,	,	,
cord-262445-54ng7m92	646	9	which	which	WDT
cord-262445-54ng7m92	646	10	characterize	characterize	VBP
cord-262445-54ng7m92	646	11	chronic	chronic	JJ
cord-262445-54ng7m92	646	12	degenerative	degenerative	JJ
cord-262445-54ng7m92	646	13	conditions	condition	NNS
cord-262445-54ng7m92	646	14	,	,	,
cord-262445-54ng7m92	646	15	can	can	MD
cord-262445-54ng7m92	646	16	alter	alter	VB
cord-262445-54ng7m92	646	17	muscle	muscle	NN
cord-262445-54ng7m92	646	18	milieu	milieu	NN
cord-262445-54ng7m92	646	19	,	,	,
cord-262445-54ng7m92	646	20	linking	link	VBG
cord-262445-54ng7m92	646	21	the	the	DT
cord-262445-54ng7m92	646	22	generation	generation	NN
cord-262445-54ng7m92	646	23	of	of	IN
cord-262445-54ng7m92	646	24	oxidative	oxidative	JJ
cord-262445-54ng7m92	646	25	stimuli	stimulus	NNS
cord-262445-54ng7m92	646	26	to	to	IN
cord-262445-54ng7m92	646	27	the	the	DT
cord-262445-54ng7m92	646	28	promotion	promotion	NN
cord-262445-54ng7m92	646	29	of	of	IN
cord-262445-54ng7m92	646	30	inflammatory	inflammatory	JJ
cord-262445-54ng7m92	646	31	changes	change	NNS
cord-262445-54ng7m92	646	32	.	.	.
cord-262445-54ng7m92	647	1	Background	background	NN
cord-262445-54ng7m92	647	2	:	:	:
cord-262445-54ng7m92	648	1	Facioscapulohumeral	Facioscapulohumeral	NNP
cord-262445-54ng7m92	648	2	Muscular	muscular	JJ
cord-262445-54ng7m92	648	3	Dystrophy	Dystrophy	NNP
cord-262445-54ng7m92	648	4	(	(	-LRB-
cord-262445-54ng7m92	648	5	FSHD	FSHD	NNP
cord-262445-54ng7m92	648	6	)	)	-RRB-
cord-262445-54ng7m92	648	7	is	be	VBZ
cord-262445-54ng7m92	648	8	a	a	DT
cord-262445-54ng7m92	648	9	frequent	frequent	JJ
cord-262445-54ng7m92	648	10	neuromuscular	neuromuscular	JJ
cord-262445-54ng7m92	648	11	disease	disease	NN
cord-262445-54ng7m92	648	12	caused	cause	VBN
cord-262445-54ng7m92	648	13	by	by	IN
cord-262445-54ng7m92	648	14	epigenetic	epigenetic	JJ
cord-262445-54ng7m92	648	15	alterations	alteration	NNS
cord-262445-54ng7m92	648	16	on	on	IN
cord-262445-54ng7m92	648	17	the	the	DT
cord-262445-54ng7m92	648	18	4q35	4q35	CD
cord-262445-54ng7m92	648	19	chromosome	chromosome	NN
cord-262445-54ng7m92	648	20	leading	lead	VBG
cord-262445-54ng7m92	648	21	to	to	IN
cord-262445-54ng7m92	648	22	gain	gain	NN
cord-262445-54ng7m92	648	23	of	of	IN
cord-262445-54ng7m92	648	24	expression	expression	NN
cord-262445-54ng7m92	648	25	of	of	IN
cord-262445-54ng7m92	648	26	the	the	DT
cord-262445-54ng7m92	648	27	double	double	JJ
cord-262445-54ng7m92	648	28	homeobox	homeobox	NN
cord-262445-54ng7m92	648	29	4	4	CD
cord-262445-54ng7m92	648	30	(	(	-LRB-
cord-262445-54ng7m92	648	31	DUX4	DUX4	NNP
cord-262445-54ng7m92	648	32	)	)	-RRB-
cord-262445-54ng7m92	648	33	gene	gene	NN
cord-262445-54ng7m92	648	34	.	.	.
cord-262445-54ng7m92	649	1	Our	-PRON-	PRP$
cord-262445-54ng7m92	649	2	laboratory	laboratory	NN
cord-262445-54ng7m92	649	3	previously	previously	RB
cord-262445-54ng7m92	649	4	showed	show	VBD
cord-262445-54ng7m92	649	5	that	that	IN
cord-262445-54ng7m92	649	6	the	the	DT
cord-262445-54ng7m92	649	7	long	long	JJ
cord-262445-54ng7m92	649	8	non	non	JJ
cord-262445-54ng7m92	649	9	-	-	JJ
cord-262445-54ng7m92	649	10	coding	coding	JJ
cord-262445-54ng7m92	649	11	RNA	RNA	NNP
cord-262445-54ng7m92	649	12	DBE	DBE	NNP
cord-262445-54ng7m92	649	13	-	-	HYPH
cord-262445-54ng7m92	649	14	T	T	NNP
cord-262445-54ng7m92	649	15	is	be	VBZ
cord-262445-54ng7m92	649	16	required	require	VBN
cord-262445-54ng7m92	649	17	for	for	IN
cord-262445-54ng7m92	649	18	aberrant	aberrant	JJ
cord-262445-54ng7m92	649	19	DUX4	DUX4	NNP
cord-262445-54ng7m92	649	20	expression	expression	NN
cord-262445-54ng7m92	649	21	in	in	IN
cord-262445-54ng7m92	649	22	FSHD	FSHD	NNP
cord-262445-54ng7m92	649	23	.	.	.
cord-262445-54ng7m92	650	1	Using	use	VBG
cord-262445-54ng7m92	650	2	affinity	affinity	NN
cord-262445-54ng7m92	650	3	purification	purification	NN
cord-262445-54ng7m92	650	4	followed	follow	VBN
cord-262445-54ng7m92	650	5	by	by	IN
cord-262445-54ng7m92	650	6	proteomics	proteomic	NNS
cord-262445-54ng7m92	650	7	,	,	,
cord-262445-54ng7m92	650	8	we	-PRON-	PRP
cord-262445-54ng7m92	650	9	identified	identify	VBD
cord-262445-54ng7m92	650	10	the	the	DT
cord-262445-54ng7m92	650	11	chromatin	chromatin	NN
cord-262445-54ng7m92	650	12	remodeling	remodeling	NN
cord-262445-54ng7m92	650	13	protein	protein	NN
cord-262445-54ng7m92	650	14	WDR5	WDR5	NNP
cord-262445-54ng7m92	650	15	,	,	,
cord-262445-54ng7m92	650	16	a	a	DT
cord-262445-54ng7m92	650	17	core	core	NN
cord-262445-54ng7m92	650	18	component	component	NN
cord-262445-54ng7m92	650	19	of	of	IN
cord-262445-54ng7m92	650	20	the	the	DT
cord-262445-54ng7m92	650	21	MLL	MLL	NNP
cord-262445-54ng7m92	650	22	/	/	SYM
cord-262445-54ng7m92	650	23	SET1	SET1	NNP
cord-262445-54ng7m92	650	24	epigenetic	epigenetic	JJ
cord-262445-54ng7m92	650	25	activation	activation	NN
cord-262445-54ng7m92	650	26	complex	complex	NN
cord-262445-54ng7m92	650	27	,	,	,
cord-262445-54ng7m92	650	28	as	as	IN
cord-262445-54ng7m92	650	29	a	a	DT
cord-262445-54ng7m92	650	30	novel	novel	JJ
cord-262445-54ng7m92	650	31	DBE	DBE	NNP
cord-262445-54ng7m92	650	32	-	-	HYPH
cord-262445-54ng7m92	650	33	T	T	NNP
cord-262445-54ng7m92	650	34	interactor	interactor	NN
cord-262445-54ng7m92	650	35	.	.	.
cord-262445-54ng7m92	651	1	The	the	DT
cord-262445-54ng7m92	651	2	goal	goal	NN
cord-262445-54ng7m92	651	3	of	of	IN
cord-262445-54ng7m92	651	4	this	this	DT
cord-262445-54ng7m92	651	5	work	work	NN
cord-262445-54ng7m92	651	6	is	be	VBZ
cord-262445-54ng7m92	651	7	to	to	TO
cord-262445-54ng7m92	651	8	analyze	analyze	VB
cord-262445-54ng7m92	651	9	the	the	DT
cord-262445-54ng7m92	651	10	role	role	NN
cord-262445-54ng7m92	651	11	of	of	IN
cord-262445-54ng7m92	651	12	WDR5	WDR5	NNP
cord-262445-54ng7m92	651	13	on	on	IN
cord-262445-54ng7m92	651	14	the	the	DT
cord-262445-54ng7m92	651	15	regulation	regulation	NN
cord-262445-54ng7m92	651	16	of	of	IN
cord-262445-54ng7m92	651	17	DUX4	DUX4	NNP
cord-262445-54ng7m92	651	18	in	in	IN
cord-262445-54ng7m92	651	19	FSHD	FSHD	NNP
cord-262445-54ng7m92	651	20	.	.	.
cord-262445-54ng7m92	652	1	Methods	method	NNS
cord-262445-54ng7m92	652	2	:	:	:
cord-262445-54ng7m92	652	3	Primary	primary	JJ
cord-262445-54ng7m92	652	4	myoblast	myoblast	NN
cord-262445-54ng7m92	652	5	isolated	isolate	VBN
cord-262445-54ng7m92	652	6	from	from	IN
cord-262445-54ng7m92	652	7	both	both	DT
cord-262445-54ng7m92	652	8	FSHD	FSHD	NNP
cord-262445-54ng7m92	652	9	and	and	CC
cord-262445-54ng7m92	652	10	healthy	healthy	JJ
cord-262445-54ng7m92	652	11	control	control	NN
cord-262445-54ng7m92	652	12	subjects	subject	NNS
cord-262445-54ng7m92	652	13	were	be	VBD
cord-262445-54ng7m92	652	14	differentiated	differentiate	VBN
cord-262445-54ng7m92	652	15	in	in	IN
cord-262445-54ng7m92	652	16	myotubes	myotube	NNS
cord-262445-54ng7m92	652	17	in	in	IN
cord-262445-54ng7m92	652	18	presence	presence	NN
cord-262445-54ng7m92	652	19	of	of	IN
cord-262445-54ng7m92	652	20	siRNAs	siRNAs	NNP
cord-262445-54ng7m92	652	21	.	.	.
cord-262445-54ng7m92	653	1	24	24	CD
cord-262445-54ng7m92	653	2	hours	hour	NNS
cord-262445-54ng7m92	653	3	after	after	IN
cord-262445-54ng7m92	653	4	induction	induction	NN
cord-262445-54ng7m92	653	5	of	of	IN
cord-262445-54ng7m92	653	6	differentiation	differentiation	NN
cord-262445-54ng7m92	653	7	,	,	,
cord-262445-54ng7m92	653	8	myotubes	myotube	NNS
cord-262445-54ng7m92	653	9	have	have	VBP
cord-262445-54ng7m92	653	10	been	be	VBN
cord-262445-54ng7m92	653	11	transfected	transfecte	VBN
cord-262445-54ng7m92	653	12	with	with	IN
cord-262445-54ng7m92	653	13	siRNA	siRNA	NNP
cord-262445-54ng7m92	653	14	on	on	IN
cord-262445-54ng7m92	653	15	-	-	HYPH
cord-262445-54ng7m92	653	16	target	target	NN
cord-262445-54ng7m92	653	17	WDR5	WDR5	NNP
cord-262445-54ng7m92	653	18	and	and	CC
cord-262445-54ng7m92	653	19	siRNA	sirna	NN
cord-262445-54ng7m92	653	20	non	non	JJ
cord-262445-54ng7m92	653	21	-	-	JJ
cord-262445-54ng7m92	653	22	targeting	targeting	JJ
cord-262445-54ng7m92	653	23	as	as	IN
cord-262445-54ng7m92	653	24	control	control	NN
cord-262445-54ng7m92	653	25	.	.	.
cord-262445-54ng7m92	654	1	Four	four	CD
cord-262445-54ng7m92	654	2	days	day	NNS
cord-262445-54ng7m92	654	3	after	after	IN
cord-262445-54ng7m92	654	4	differentiation	differentiation	NN
cord-262445-54ng7m92	654	5	in	in	IN
cord-262445-54ng7m92	654	6	mature	mature	JJ
cord-262445-54ng7m92	654	7	myotubes	myotube	NNS
cord-262445-54ng7m92	654	8	the	the	DT
cord-262445-54ng7m92	654	9	expression	expression	NN
cord-262445-54ng7m92	654	10	level	level	NN
cord-262445-54ng7m92	654	11	of	of	IN
cord-262445-54ng7m92	654	12	DUX4	DUX4	NNP
cord-262445-54ng7m92	654	13	and	and	CC
cord-262445-54ng7m92	654	14	its	-PRON-	PRP$
cord-262445-54ng7m92	654	15	known	know	VBN
cord-262445-54ng7m92	654	16	targets	target	NNS
cord-262445-54ng7m92	654	17	have	have	VBP
cord-262445-54ng7m92	654	18	been	be	VBN
cord-262445-54ng7m92	654	19	assessed	assess	VBN
cord-262445-54ng7m92	654	20	with	with	IN
cord-262445-54ng7m92	654	21	qRT	qrt	ADD
cord-262445-54ng7m92	654	22	-	-	HYPH
cord-262445-54ng7m92	654	23	PCR	PCR	NNP
cord-262445-54ng7m92	654	24	.	.	.
cord-262445-54ng7m92	655	1	Moreover	moreover	RB
cord-262445-54ng7m92	655	2	,	,	,
cord-262445-54ng7m92	655	3	the	the	DT
cord-262445-54ng7m92	655	4	myogenic	myogenic	NNP
cord-262445-54ng7m92	655	5	differentiating	differentiate	VBG
cord-262445-54ng7m92	655	6	level	level	NN
cord-262445-54ng7m92	655	7	and	and	CC
cord-262445-54ng7m92	655	8	the	the	DT
cord-262445-54ng7m92	655	9	fusion	fusion	NN
cord-262445-54ng7m92	655	10	index	index	NN
cord-262445-54ng7m92	655	11	have	have	VBP
cord-262445-54ng7m92	655	12	been	be	VBN
cord-262445-54ng7m92	655	13	assessed	assess	VBN
cord-262445-54ng7m92	655	14	through	through	IN
cord-262445-54ng7m92	655	15	immunofluorescence	immunofluorescence	NN
cord-262445-54ng7m92	655	16	analysis	analysis	NN
cord-262445-54ng7m92	655	17	of	of	IN
cord-262445-54ng7m92	655	18	the	the	DT
cord-262445-54ng7m92	655	19	myosin	myosin	NN
cord-262445-54ng7m92	655	20	heavy	heavy	JJ
cord-262445-54ng7m92	655	21	chain	chain	NN
cord-262445-54ng7m92	655	22	(	(	-LRB-
cord-262445-54ng7m92	655	23	MHC	MHC	NNP
cord-262445-54ng7m92	655	24	)	)	-RRB-
cord-262445-54ng7m92	655	25	differentiation	differentiation	NN
cord-262445-54ng7m92	655	26	marker	marker	NN
cord-262445-54ng7m92	655	27	.	.	.
cord-262445-54ng7m92	656	1	Results	result	NNS
cord-262445-54ng7m92	656	2	:	:	:
cord-262445-54ng7m92	657	1	We	-PRON-	PRP
cord-262445-54ng7m92	657	2	found	find	VBD
cord-262445-54ng7m92	657	3	that	that	IN
cord-262445-54ng7m92	657	4	the	the	DT
cord-262445-54ng7m92	657	5	expression	expression	NN
cord-262445-54ng7m92	657	6	level	level	NN
cord-262445-54ng7m92	657	7	of	of	IN
cord-262445-54ng7m92	657	8	DUX4	DUX4	NNP
cord-262445-54ng7m92	657	9	and	and	CC
cord-262445-54ng7m92	657	10	its	-PRON-	PRP$
cord-262445-54ng7m92	657	11	target	target	NN
cord-262445-54ng7m92	657	12	MBD3L2	MBD3L2	NNP
cord-262445-54ng7m92	657	13	,	,	,
cord-262445-54ng7m92	658	1	TRIM43	TRIM43	NNP
cord-262445-54ng7m92	659	1	and	and	CC
cord-262445-54ng7m92	659	2	TRIM48	TRIM48	NNS
cord-262445-54ng7m92	659	3	are	be	VBP
cord-262445-54ng7m92	659	4	significantly	significantly	RB
cord-262445-54ng7m92	659	5	reduced	reduce	VBN
cord-262445-54ng7m92	659	6	by	by	IN
cord-262445-54ng7m92	659	7	silencing	silence	VBG
cord-262445-54ng7m92	659	8	WDR5	WDR5	NNP
cord-262445-54ng7m92	659	9	.	.	.
cord-262445-54ng7m92	660	1	Similar	similar	JJ
cord-262445-54ng7m92	660	2	results	result	NNS
cord-262445-54ng7m92	660	3	were	be	VBD
cord-262445-54ng7m92	660	4	obtained	obtain	VBN
cord-262445-54ng7m92	660	5	using	use	VBG
cord-262445-54ng7m92	660	6	a	a	DT
cord-262445-54ng7m92	660	7	WDR5	WDR5	NNP
cord-262445-54ng7m92	660	8	small	small	JJ
cord-262445-54ng7m92	660	9	molecule	molecule	NN
cord-262445-54ng7m92	660	10	inhibitor	inhibitor	NN
cord-262445-54ng7m92	660	11	.	.	.
cord-262445-54ng7m92	661	1	Remarkably	remarkably	RB
cord-262445-54ng7m92	661	2	,	,	,
cord-262445-54ng7m92	661	3	WDR5	WDR5	NNP
cord-262445-54ng7m92	661	4	knockdown	knockdown	NN
cord-262445-54ng7m92	661	5	leads	lead	VBZ
cord-262445-54ng7m92	661	6	to	to	IN
cord-262445-54ng7m92	661	7	rescue	rescue	NN
cord-262445-54ng7m92	661	8	of	of	IN
cord-262445-54ng7m92	661	9	the	the	DT
cord-262445-54ng7m92	661	10	myogenic	myogenic	NNP
cord-262445-54ng7m92	661	11	defects	defect	NNS
cord-262445-54ng7m92	661	12	of	of	IN
cord-262445-54ng7m92	661	13	FSHD	FSHD	NNP
cord-262445-54ng7m92	661	14	muscle	muscle	NN
cord-262445-54ng7m92	661	15	cells	cell	NNS
cord-262445-54ng7m92	661	16	at	at	IN
cord-262445-54ng7m92	661	17	both	both	CC
cord-262445-54ng7m92	661	18	the	the	DT
cord-262445-54ng7m92	661	19	differentiation	differentiation	NN
cord-262445-54ng7m92	661	20	level	level	NN
cord-262445-54ng7m92	661	21	and	and	CC
cord-262445-54ng7m92	661	22	the	the	DT
cord-262445-54ng7m92	661	23	fusion	fusion	NN
cord-262445-54ng7m92	661	24	index	index	NN
cord-262445-54ng7m92	661	25	.	.	.
cord-262445-54ng7m92	662	1	Conclusion	conclusion	NN
cord-262445-54ng7m92	662	2	:	:	:
cord-262445-54ng7m92	663	1	These	these	DT
cord-262445-54ng7m92	663	2	results	result	NNS
cord-262445-54ng7m92	663	3	show	show	VBP
cord-262445-54ng7m92	663	4	the	the	DT
cord-262445-54ng7m92	663	5	pivotal	pivotal	JJ
cord-262445-54ng7m92	663	6	role	role	NN
cord-262445-54ng7m92	663	7	played	play	VBN
cord-262445-54ng7m92	663	8	by	by	IN
cord-262445-54ng7m92	663	9	WDR5	WDR5	NNP
cord-262445-54ng7m92	663	10	in	in	IN
cord-262445-54ng7m92	663	11	DUX4	DUX4	NNP
cord-262445-54ng7m92	663	12	expression	expression	NN
cord-262445-54ng7m92	663	13	and	and	CC
cord-262445-54ng7m92	663	14	candidate	candidate	NN
cord-262445-54ng7m92	663	15	WDR5	WDR5	NNP
cord-262445-54ng7m92	663	16	as	as	IN
cord-262445-54ng7m92	663	17	potential	potential	JJ
cord-262445-54ng7m92	663	18	therapeutic	therapeutic	JJ
cord-262445-54ng7m92	663	19	target	target	NN
cord-262445-54ng7m92	663	20	for	for	IN
cord-262445-54ng7m92	663	21	FSHD	FSHD	NNP
cord-262445-54ng7m92	663	22	treatment	treatment	NN
cord-262445-54ng7m92	663	23	.	.	.
cord-262445-54ng7m92	663	24	.	.	.
cord-262445-54ng7m92	664	1	The	the	DT
cord-262445-54ng7m92	664	2	purpose	purpose	NN
cord-262445-54ng7m92	664	3	of	of	IN
cord-262445-54ng7m92	664	4	this	this	DT
cord-262445-54ng7m92	664	5	work	work	NN
cord-262445-54ng7m92	664	6	has	have	VBZ
cord-262445-54ng7m92	664	7	been	be	VBN
cord-262445-54ng7m92	664	8	to	to	TO
cord-262445-54ng7m92	664	9	study	study	VB
cord-262445-54ng7m92	664	10	the	the	DT
cord-262445-54ng7m92	664	11	skeletal	skeletal	JJ
cord-262445-54ng7m92	664	12	muscle	muscle	NN
cord-262445-54ng7m92	664	13	strength	strength	NN
cord-262445-54ng7m92	664	14	development	development	NN
cord-262445-54ng7m92	664	15	,	,	,
cord-262445-54ng7m92	664	16	the	the	DT
cord-262445-54ng7m92	664	17	main	main	JJ
cord-262445-54ng7m92	664	18	feature	feature	NN
cord-262445-54ng7m92	664	19	of	of	IN
cord-262445-54ng7m92	664	20	this	this	DT
cord-262445-54ng7m92	664	21	tissue	tissue	NN
cord-262445-54ng7m92	664	22	,	,	,
cord-262445-54ng7m92	664	23	when	when	WRB
cord-262445-54ng7m92	664	24	sedentary	sedentary	JJ
cord-262445-54ng7m92	664	25	adult	adult	NN
cord-262445-54ng7m92	664	26	mice	mouse	NNS
cord-262445-54ng7m92	664	27	were	be	VBD
cord-262445-54ng7m92	664	28	exposed	expose	VBN
cord-262445-54ng7m92	664	29	to	to	IN
cord-262445-54ng7m92	664	30	ELF	ELF	NNP
cord-262445-54ng7m92	664	31	-	-	HYPH
cord-262445-54ng7m92	664	32	EMFs	emf	NNS
cord-262445-54ng7m92	664	33	.	.	.
cord-262445-54ng7m92	665	1	Male	male	JJ
cord-262445-54ng7m92	665	2	C57BL/6	C57BL/6	NNP
cord-262445-54ng7m92	665	3	sedentary	sedentary	JJ
cord-262445-54ng7m92	665	4	adult	adult	NN
cord-262445-54ng7m92	665	5	mice	mouse	NNS
cord-262445-54ng7m92	665	6	were	be	VBD
cord-262445-54ng7m92	665	7	exposed	expose	VBN
cord-262445-54ng7m92	665	8	to	to	IN
cord-262445-54ng7m92	665	9	ELF	ELF	NNP
cord-262445-54ng7m92	665	10	-	-	HYPH
cord-262445-54ng7m92	665	11	EMFs	EMFs	NNP
cord-262445-54ng7m92	665	12	(	(	-LRB-
cord-262445-54ng7m92	665	13	0.1	0.1	CD
cord-262445-54ng7m92	665	14	or	or	CC
cord-262445-54ng7m92	665	15	1	1	CD
cord-262445-54ng7m92	665	16	mT	mT	NNP
cord-262445-54ng7m92	665	17	)	)	-RRB-
cord-262445-54ng7m92	665	18	generated	generate	VBN
cord-262445-54ng7m92	665	19	by	by	IN
cord-262445-54ng7m92	665	20	a	a	DT
cord-262445-54ng7m92	665	21	solenoid	solenoid	NN
cord-262445-54ng7m92	665	22	for	for	IN
cord-262445-54ng7m92	665	23	1h	1h	CD
cord-262445-54ng7m92	665	24	/	/	SYM
cord-262445-54ng7m92	665	25	die	die	VB
cord-262445-54ng7m92	665	26	up	up	IN
cord-262445-54ng7m92	665	27	to	to	TO
cord-262445-54ng7m92	665	28	5	5	CD
cord-262445-54ng7m92	665	29	weeks	week	NNS
cord-262445-54ng7m92	665	30	and	and	CC
cord-262445-54ng7m92	665	31	fed	feed	VBN
cord-262445-54ng7m92	665	32	with	with	IN
cord-262445-54ng7m92	665	33	a	a	DT
cord-262445-54ng7m92	665	34	standard	standard	JJ
cord-262445-54ng7m92	665	35	diet	diet	NN
cord-262445-54ng7m92	665	36	or	or	CC
cord-262445-54ng7m92	665	37	a	a	DT
cord-262445-54ng7m92	665	38	N	n	CD
cord-262445-54ng7m92	665	39	-	-	HYPH
cord-262445-54ng7m92	665	40	acetyl	acetyl	NN
cord-262445-54ng7m92	665	41	-	-	HYPH
cord-262445-54ng7m92	665	42	cysteine	cysteine	NN
cord-262445-54ng7m92	665	43	(	(	-LRB-
cord-262445-54ng7m92	665	44	NAC	NAC	NNP
cord-262445-54ng7m92	665	45	)	)	-RRB-
cord-262445-54ng7m92	665	46	enriched	enrich	VBN
cord-262445-54ng7m92	665	47	diet	diet	NN
cord-262445-54ng7m92	665	48	.	.	.
cord-262445-54ng7m92	666	1	Grip	grip	NN
cord-262445-54ng7m92	666	2	strength	strength	NN
cord-262445-54ng7m92	666	3	and	and	CC
cord-262445-54ng7m92	666	4	body	body	NN
cord-262445-54ng7m92	666	5	weight	weight	NN
cord-262445-54ng7m92	666	6	were	be	VBD
cord-262445-54ng7m92	666	7	measured	measure	VBN
cord-262445-54ng7m92	666	8	weekly	weekly	RB
cord-262445-54ng7m92	666	9	,	,	,
cord-262445-54ng7m92	666	10	and	and	CC
cord-262445-54ng7m92	666	11	after	after	IN
cord-262445-54ng7m92	666	12	5	5	CD
cord-262445-54ng7m92	666	13	week	week	NN
cord-262445-54ng7m92	666	14	exposure	exposure	NN
cord-262445-54ng7m92	666	15	the	the	DT
cord-262445-54ng7m92	666	16	mice	mouse	NNS
cord-262445-54ng7m92	666	17	were	be	VBD
cord-262445-54ng7m92	666	18	sacrificed	sacrifice	VBN
cord-262445-54ng7m92	666	19	and	and	CC
cord-262445-54ng7m92	666	20	skeletal	skeletal	JJ
cord-262445-54ng7m92	666	21	muscle	muscle	NN
cord-262445-54ng7m92	666	22	from	from	IN
cord-262445-54ng7m92	666	23	hind	hind	NN
cord-262445-54ng7m92	666	24	limbs	limb	NNS
cord-262445-54ng7m92	666	25	were	be	VBD
cord-262445-54ng7m92	666	26	isolated	isolate	VBN
cord-262445-54ng7m92	666	27	and	and	CC
cord-262445-54ng7m92	666	28	collected	collect	VBN
cord-262445-54ng7m92	666	29	for	for	IN
cord-262445-54ng7m92	666	30	biochemical	biochemical	JJ
cord-262445-54ng7m92	666	31	analyses	analysis	NNS
cord-262445-54ng7m92	666	32	.	.	.
cord-262445-54ng7m92	667	1	The	the	DT
cord-262445-54ng7m92	667	2	ELF	ELF	NNP
cord-262445-54ng7m92	667	3	-	-	HYPH
cord-262445-54ng7m92	667	4	EMFs	emf	NNS
cord-262445-54ng7m92	667	5	did	do	VBD
cord-262445-54ng7m92	667	6	not	not	RB
cord-262445-54ng7m92	667	7	affect	affect	VB
cord-262445-54ng7m92	667	8	the	the	DT
cord-262445-54ng7m92	667	9	body	body	NN
cord-262445-54ng7m92	667	10	weight	weight	NN
cord-262445-54ng7m92	667	11	and	and	CC
cord-262445-54ng7m92	667	12	,	,	,
cord-262445-54ng7m92	667	13	conversely	conversely	RB
cord-262445-54ng7m92	667	14	,	,	,
cord-262445-54ng7m92	667	15	increased	increase	VBD
cord-262445-54ng7m92	667	16	the	the	DT
cord-262445-54ng7m92	667	17	grip	grip	NN
cord-262445-54ng7m92	667	18	strength	strength	NN
cord-262445-54ng7m92	667	19	in	in	IN
cord-262445-54ng7m92	667	20	exposed	expose	VBN
cord-262445-54ng7m92	667	21	mice	mouse	NNS
cord-262445-54ng7m92	667	22	in	in	IN
cord-262445-54ng7m92	667	23	comparison	comparison	NN
cord-262445-54ng7m92	667	24	to	to	IN
cord-262445-54ng7m92	667	25	non	non	JJ
cord-262445-54ng7m92	667	26	-	-	JJ
cord-262445-54ng7m92	667	27	exposed	expose	VBN
cord-262445-54ng7m92	667	28	ones	one	NNS
cord-262445-54ng7m92	667	29	.	.	.
cord-262445-54ng7m92	668	1	In	in	IN
cord-262445-54ng7m92	668	2	addition	addition	NN
cord-262445-54ng7m92	668	3	,	,	,
cord-262445-54ng7m92	668	4	both	both	CC
cord-262445-54ng7m92	668	5	the	the	DT
cord-262445-54ng7m92	668	6	expression	expression	NN
cord-262445-54ng7m92	668	7	levels	level	NNS
cord-262445-54ng7m92	668	8	of	of	IN
cord-262445-54ng7m92	668	9	Pax7	Pax7	NNP
cord-262445-54ng7m92	668	10	and	and	CC
cord-262445-54ng7m92	668	11	of	of	IN
cord-262445-54ng7m92	668	12	myosin	myosin	NN
cord-262445-54ng7m92	668	13	heavy	heavy	JJ
cord-262445-54ng7m92	668	14	chain	chain	NN
cord-262445-54ng7m92	668	15	were	be	VBD
cord-262445-54ng7m92	668	16	found	find	VBN
cord-262445-54ng7m92	668	17	increased	increase	VBN
cord-262445-54ng7m92	668	18	in	in	IN
cord-262445-54ng7m92	668	19	muscle	muscle	NN
cord-262445-54ng7m92	668	20	isolated	isolate	VBN
cord-262445-54ng7m92	668	21	from	from	IN
cord-262445-54ng7m92	668	22	exposed	expose	VBN
cord-262445-54ng7m92	668	23	mice	mouse	NNS
cord-262445-54ng7m92	668	24	.	.	.
cord-262445-54ng7m92	669	1	The	the	DT
cord-262445-54ng7m92	669	2	ELF	ELF	NNP
cord-262445-54ng7m92	669	3	-	-	HYPH
cord-262445-54ng7m92	669	4	EMFs	EMFs	NNP
cord-262445-54ng7m92	669	5	failed	fail	VBD
cord-262445-54ng7m92	669	6	to	to	TO
cord-262445-54ng7m92	669	7	trigger	trigger	VB
cord-262445-54ng7m92	669	8	their	-PRON-	PRP$
cord-262445-54ng7m92	669	9	effects	effect	NNS
cord-262445-54ng7m92	669	10	when	when	WRB
cord-262445-54ng7m92	669	11	the	the	DT
cord-262445-54ng7m92	669	12	mice	mouse	NNS
cord-262445-54ng7m92	669	13	were	be	VBD
cord-262445-54ng7m92	669	14	fed	feed	VBN
cord-262445-54ng7m92	669	15	with	with	IN
cord-262445-54ng7m92	669	16	an	an	DT
cord-262445-54ng7m92	669	17	NAC	NAC	NNP
cord-262445-54ng7m92	669	18	-	-	HYPH
cord-262445-54ng7m92	669	19	enriched	enrich	VBN
cord-262445-54ng7m92	669	20	diet	diet	NN
cord-262445-54ng7m92	669	21	.	.	.
cord-262445-54ng7m92	670	1	These	these	DT
cord-262445-54ng7m92	670	2	preliminary	preliminary	JJ
cord-262445-54ng7m92	670	3	data	datum	NNS
cord-262445-54ng7m92	670	4	suggest	suggest	VBP
cord-262445-54ng7m92	670	5	that	that	IN
cord-262445-54ng7m92	670	6	ELF	ELF	NNP
cord-262445-54ng7m92	670	7	-	-	HYPH
cord-262445-54ng7m92	670	8	EMFs	emf	NNS
cord-262445-54ng7m92	670	9	may	may	MD
cord-262445-54ng7m92	670	10	provide	provide	VB
cord-262445-54ng7m92	670	11	some	some	DT
cord-262445-54ng7m92	670	12	benefits	benefit	NNS
cord-262445-54ng7m92	670	13	improving	improve	VBG
cord-262445-54ng7m92	670	14	the	the	DT
cord-262445-54ng7m92	670	15	muscle	muscle	NN
cord-262445-54ng7m92	670	16	fitness	fitness	NN
cord-262445-54ng7m92	670	17	in	in	IN
cord-262445-54ng7m92	670	18	sedentary	sedentary	JJ
cord-262445-54ng7m92	670	19	adult	adult	NN
cord-262445-54ng7m92	670	20	mice	mouse	NNS
cord-262445-54ng7m92	670	21	.	.	.
cord-262445-54ng7m92	671	1	The	the	DT
cord-262445-54ng7m92	671	2	current	current	JJ
cord-262445-54ng7m92	671	3	leading	lead	VBG
cord-262445-54ng7m92	671	4	cause	cause	NN
cord-262445-54ng7m92	671	5	of	of	IN
cord-262445-54ng7m92	671	6	death	death	NN
cord-262445-54ng7m92	671	7	in	in	IN
cord-262445-54ng7m92	671	8	Duchenne	Duchenne	NNP
cord-262445-54ng7m92	671	9	's	's	POS
cord-262445-54ng7m92	671	10	Muscular	muscular	JJ
cord-262445-54ng7m92	671	11	Dystrophy	Dystrophy	NNP
cord-262445-54ng7m92	671	12	(	(	-LRB-
cord-262445-54ng7m92	671	13	DMD	DMD	NNP
cord-262445-54ng7m92	671	14	)	)	-RRB-
cord-262445-54ng7m92	671	15	patients	patient	NNS
cord-262445-54ng7m92	671	16	is	be	VBZ
cord-262445-54ng7m92	671	17	cardio	cardio	JJ
cord-262445-54ng7m92	671	18	-	-	HYPH
cord-262445-54ng7m92	671	19	respiratory	respiratory	JJ
cord-262445-54ng7m92	671	20	failure	failure	NN
cord-262445-54ng7m92	671	21	,	,	,
cord-262445-54ng7m92	671	22	mainly	mainly	RB
cord-262445-54ng7m92	671	23	due	due	IN
cord-262445-54ng7m92	671	24	to	to	IN
cord-262445-54ng7m92	671	25	heart	heart	NN
cord-262445-54ng7m92	671	26	and	and	CC
cord-262445-54ng7m92	671	27	diaphragm	diaphragm	NN
cord-262445-54ng7m92	671	28	(	(	-LRB-
cord-262445-54ng7m92	671	29	DIA	DIA	NNP
cord-262445-54ng7m92	671	30	)	)	-RRB-
cord-262445-54ng7m92	671	31	damage	damage	NN
cord-262445-54ng7m92	671	32	and	and	CC
cord-262445-54ng7m92	671	33	fibrosis	fibrosis	NN
cord-262445-54ng7m92	671	34	during	during	IN
cord-262445-54ng7m92	671	35	the	the	DT
cord-262445-54ng7m92	671	36	late	late	JJ
cord-262445-54ng7m92	671	37	stage	stage	NN
cord-262445-54ng7m92	671	38	of	of	IN
cord-262445-54ng7m92	671	39	the	the	DT
cord-262445-54ng7m92	671	40	disease	disease	NN
cord-262445-54ng7m92	671	41	.	.	.
cord-262445-54ng7m92	672	1	Given	give	VBN
cord-262445-54ng7m92	672	2	that	that	DT
cord-262445-54ng7m92	672	3	fibrosis	fibrosis	NN
cord-262445-54ng7m92	672	4	is	be	VBZ
cord-262445-54ng7m92	672	5	considered	consider	VBN
cord-262445-54ng7m92	672	6	a	a	DT
cord-262445-54ng7m92	672	7	consequence	consequence	NN
cord-262445-54ng7m92	672	8	of	of	IN
cord-262445-54ng7m92	672	9	muscle	muscle	NN
cord-262445-54ng7m92	672	10	inflammation	inflammation	NN
cord-262445-54ng7m92	672	11	,	,	,
cord-262445-54ng7m92	672	12	the	the	DT
cord-262445-54ng7m92	672	13	role	role	NN
cord-262445-54ng7m92	672	14	of	of	IN
cord-262445-54ng7m92	672	15	the	the	DT
cord-262445-54ng7m92	672	16	immune	immune	JJ
cord-262445-54ng7m92	672	17	response	response	NN
cord-262445-54ng7m92	672	18	in	in	IN
cord-262445-54ng7m92	672	19	DMD	DMD	NNP
cord-262445-54ng7m92	672	20	heart	heart	NN
cord-262445-54ng7m92	672	21	and	and	CC
cord-262445-54ng7m92	672	22	diaphragm	diaphragm	NN
cord-262445-54ng7m92	672	23	should	should	MD
cord-262445-54ng7m92	672	24	be	be	VB
cord-262445-54ng7m92	672	25	considered	consider	VBN
cord-262445-54ng7m92	672	26	,	,	,
cord-262445-54ng7m92	672	27	to	to	TO
cord-262445-54ng7m92	672	28	better	better	RB
cord-262445-54ng7m92	672	29	understand	understand	VB
cord-262445-54ng7m92	672	30	the	the	DT
cord-262445-54ng7m92	672	31	pathological	pathological	JJ
cord-262445-54ng7m92	672	32	events	event	NNS
cord-262445-54ng7m92	672	33	during	during	IN
cord-262445-54ng7m92	672	34	and	and	CC
cord-262445-54ng7m92	672	35	prior	prior	RB
cord-262445-54ng7m92	672	36	to	to	IN
cord-262445-54ng7m92	672	37	the	the	DT
cord-262445-54ng7m92	672	38	onset	onset	NN
cord-262445-54ng7m92	672	39	of	of	IN
cord-262445-54ng7m92	672	40	fibrosis	fibrosis	NN
cord-262445-54ng7m92	672	41	.	.	.
cord-262445-54ng7m92	673	1	Indeed	indeed	RB
cord-262445-54ng7m92	673	2	,	,	,
cord-262445-54ng7m92	673	3	very	very	RB
cord-262445-54ng7m92	673	4	little	little	JJ
cord-262445-54ng7m92	673	5	is	be	VBZ
cord-262445-54ng7m92	673	6	known	know	VBN
cord-262445-54ng7m92	673	7	about	about	IN
cord-262445-54ng7m92	673	8	the	the	DT
cord-262445-54ng7m92	673	9	kinetics	kinetic	NNS
cord-262445-54ng7m92	673	10	of	of	IN
cord-262445-54ng7m92	673	11	immune	immune	JJ
cord-262445-54ng7m92	673	12	cells	cell	NNS
cord-262445-54ng7m92	673	13	infiltration	infiltration	NN
cord-262445-54ng7m92	673	14	in	in	IN
cord-262445-54ng7m92	673	15	dystrophic	dystrophic	JJ
cord-262445-54ng7m92	673	16	heart	heart	NN
cord-262445-54ng7m92	673	17	and	and	CC
cord-262445-54ng7m92	673	18	diaphragm	diaphragm	NN
cord-262445-54ng7m92	673	19	,	,	,
cord-262445-54ng7m92	673	20	that	that	DT
cord-262445-54ng7m92	673	21	likely	likely	RB
cord-262445-54ng7m92	673	22	contributes	contribute	VBZ
cord-262445-54ng7m92	673	23	to	to	IN
cord-262445-54ng7m92	673	24	the	the	DT
cord-262445-54ng7m92	673	25	fibrosis	fibrosis	NN
cord-262445-54ng7m92	673	26	and	and	CC
cord-262445-54ng7m92	673	27	chronic	chronic	JJ
cord-262445-54ng7m92	673	28	inflammation	inflammation	NN
cord-262445-54ng7m92	673	29	.	.	.
cord-262445-54ng7m92	674	1	The	the	DT
cord-262445-54ng7m92	674	2	treatment	treatment	NN
cord-262445-54ng7m92	674	3	of	of	IN
cord-262445-54ng7m92	674	4	choice	choice	NN
cord-262445-54ng7m92	674	5	in	in	IN
cord-262445-54ng7m92	674	6	dystrophic	dystrophic	JJ
cord-262445-54ng7m92	674	7	patient	patient	NN
cord-262445-54ng7m92	674	8	is	be	VBZ
cord-262445-54ng7m92	674	9	the	the	DT
cord-262445-54ng7m92	674	10	use	use	NN
cord-262445-54ng7m92	674	11	of	of	IN
cord-262445-54ng7m92	674	12	corticosteroids	corticosteroid	NNS
cord-262445-54ng7m92	674	13	,	,	,
cord-262445-54ng7m92	674	14	supporting	support	VBG
cord-262445-54ng7m92	674	15	an	an	DT
cord-262445-54ng7m92	674	16	important	important	JJ
cord-262445-54ng7m92	674	17	role	role	NN
cord-262445-54ng7m92	674	18	of	of	IN
cord-262445-54ng7m92	674	19	the	the	DT
cord-262445-54ng7m92	674	20	inflammatory	inflammatory	JJ
cord-262445-54ng7m92	674	21	compartment	compartment	NN
cord-262445-54ng7m92	674	22	in	in	IN
cord-262445-54ng7m92	674	23	the	the	DT
cord-262445-54ng7m92	674	24	disease	disease	NN
cord-262445-54ng7m92	674	25	progress	progress	NN
cord-262445-54ng7m92	674	26	.	.	.
cord-262445-54ng7m92	675	1	The	the	DT
cord-262445-54ng7m92	675	2	several	several	JJ
cord-262445-54ng7m92	675	3	and	and	CC
cord-262445-54ng7m92	675	4	severe	severe	JJ
cord-262445-54ng7m92	675	5	adverse	adverse	JJ
cord-262445-54ng7m92	675	6	effects	effect	NNS
cord-262445-54ng7m92	675	7	of	of	IN
cord-262445-54ng7m92	675	8	long	long	JJ
cord-262445-54ng7m92	675	9	-	-	HYPH
cord-262445-54ng7m92	675	10	term	term	NN
cord-262445-54ng7m92	675	11	corticosteroid	corticosteroid	NN
cord-262445-54ng7m92	675	12	treatment	treatment	NN
cord-262445-54ng7m92	675	13	also	also	RB
cord-262445-54ng7m92	675	14	highlight	highlight	VBP
cord-262445-54ng7m92	675	15	the	the	DT
cord-262445-54ng7m92	675	16	need	need	NN
cord-262445-54ng7m92	675	17	for	for	IN
cord-262445-54ng7m92	675	18	other	other	JJ
cord-262445-54ng7m92	675	19	anti	anti	JJ
cord-262445-54ng7m92	675	20	-	-	JJ
cord-262445-54ng7m92	675	21	inflammatory	inflammatory	JJ
cord-262445-54ng7m92	675	22	approaches	approach	NNS
cord-262445-54ng7m92	675	23	.	.	.
cord-262445-54ng7m92	676	1	Our	-PRON-	PRP$
cord-262445-54ng7m92	676	2	group	group	NN
cord-262445-54ng7m92	676	3	recently	recently	RB
cord-262445-54ng7m92	676	4	found	find	VBD
cord-262445-54ng7m92	676	5	that	that	IN
cord-262445-54ng7m92	676	6	pharmaceutical	pharmaceutical	NN
cord-262445-54ng7m92	676	7	-46	-46	NN
cord-262445-54ng7m92	676	8	-inhibition	-inhibition	NN
cord-262445-54ng7m92	676	9	of	of	IN
cord-262445-54ng7m92	676	10	Protein	Protein	NNP
cord-262445-54ng7m92	676	11	Kinase	Kinase	NNP
cord-262445-54ng7m92	676	12	C	C	NNP
cord-262445-54ng7m92	676	13	theta	theta	NN
cord-262445-54ng7m92	676	14	prevented	prevent	VBD
cord-262445-54ng7m92	676	15	damage	damage	NN
cord-262445-54ng7m92	676	16	in	in	IN
cord-262445-54ng7m92	676	17	limb	limb	NN
cord-262445-54ng7m92	676	18	skeletal	skeletal	JJ
cord-262445-54ng7m92	676	19	muscle	muscle	NN
cord-262445-54ng7m92	676	20	and	and	CC
cord-262445-54ng7m92	676	21	ameliorated	ameliorated	JJ
cord-262445-54ng7m92	676	22	disease	disease	NN
cord-262445-54ng7m92	676	23	when	when	WRB
cord-262445-54ng7m92	676	24	administered	administer	VBN
cord-262445-54ng7m92	676	25	in	in	IN
cord-262445-54ng7m92	676	26	young	young	JJ
cord-262445-54ng7m92	676	27	(	(	-LRB-
cord-262445-54ng7m92	676	28	2week	2week	JJ
cord-262445-54ng7m92	676	29	-	-	HYPH
cord-262445-54ng7m92	676	30	old	old	JJ
cord-262445-54ng7m92	676	31	)	)	-RRB-
cord-262445-54ng7m92	676	32	mdx	mdx	NN
cord-262445-54ng7m92	676	33	mice	mouse	NNS
cord-262445-54ng7m92	676	34	,	,	,
cord-262445-54ng7m92	676	35	acting	act	VBG
cord-262445-54ng7m92	676	36	predominantly	predominantly	RB
cord-262445-54ng7m92	676	37	through	through	IN
cord-262445-54ng7m92	676	38	inhibition	inhibition	NN
cord-262445-54ng7m92	676	39	of	of	IN
cord-262445-54ng7m92	676	40	early	early	JJ
cord-262445-54ng7m92	676	41	T	t	NN
cord-262445-54ng7m92	676	42	cell	cell	NN
cord-262445-54ng7m92	676	43	infiltration	infiltration	NN
cord-262445-54ng7m92	676	44	of	of	IN
cord-262445-54ng7m92	676	45	dystrophic	dystrophic	JJ
cord-262445-54ng7m92	676	46	muscle	muscle	NN
cord-262445-54ng7m92	676	47	.	.	.
cord-262445-54ng7m92	677	1	We	-PRON-	PRP
cord-262445-54ng7m92	677	2	now	now	RB
cord-262445-54ng7m92	677	3	plan	plan	VBP
cord-262445-54ng7m92	677	4	to	to	TO
cord-262445-54ng7m92	677	5	study	study	VB
cord-262445-54ng7m92	677	6	in	in	IN
cord-262445-54ng7m92	677	7	detail	detail	NN
cord-262445-54ng7m92	677	8	the	the	DT
cord-262445-54ng7m92	677	9	inflammatory	inflammatory	JJ
cord-262445-54ng7m92	677	10	compartment	compartment	NN
cord-262445-54ng7m92	677	11	of	of	IN
cord-262445-54ng7m92	677	12	dystrophic	dystrophic	JJ
cord-262445-54ng7m92	677	13	heart	heart	NN
cord-262445-54ng7m92	677	14	and	and	CC
cord-262445-54ng7m92	677	15	DIA	DIA	NNP
cord-262445-54ng7m92	677	16	using	use	VBG
cord-262445-54ng7m92	677	17	the	the	DT
cord-262445-54ng7m92	677	18	mouse	mouse	NN
cord-262445-54ng7m92	677	19	model	model	NN
cord-262445-54ng7m92	677	20	of	of	IN
cord-262445-54ng7m92	677	21	DMD	DMD	NNP
cord-262445-54ng7m92	677	22	,	,	,
cord-262445-54ng7m92	677	23	mdx	mdx	NNP
cord-262445-54ng7m92	677	24	.	.	.
cord-262445-54ng7m92	678	1	We	-PRON-	PRP
cord-262445-54ng7m92	678	2	will	will	MD
cord-262445-54ng7m92	678	3	characterize	characterize	VB
cord-262445-54ng7m92	678	4	in	in	IN
cord-262445-54ng7m92	678	5	detail	detail	NN
cord-262445-54ng7m92	678	6	the	the	DT
cord-262445-54ng7m92	678	7	kinetics	kinetic	NNS
cord-262445-54ng7m92	678	8	and	and	CC
cord-262445-54ng7m92	678	9	quality	quality	NN
cord-262445-54ng7m92	678	10	of	of	IN
cord-262445-54ng7m92	678	11	inflammatory	inflammatory	JJ
cord-262445-54ng7m92	678	12	cell	cell	NN
cord-262445-54ng7m92	678	13	populations	population	NNS
cord-262445-54ng7m92	678	14	in	in	IN
cord-262445-54ng7m92	678	15	mdx	mdx	NNP
cord-262445-54ng7m92	678	16	heart	heart	NN
cord-262445-54ng7m92	678	17	and	and	CC
cord-262445-54ng7m92	678	18	DIA	DIA	NNP
cord-262445-54ng7m92	678	19	,	,	,
cord-262445-54ng7m92	678	20	using	use	VBG
cord-262445-54ng7m92	678	21	our	-PRON-	PRP$
cord-262445-54ng7m92	678	22	established	establish	VBN
cord-262445-54ng7m92	678	23	9	9	CD
cord-262445-54ng7m92	678	24	color	color	NN
cord-262445-54ng7m92	678	25	cytofluorimetric	cytofluorimetric	NN
cord-262445-54ng7m92	678	26	protocol	protocol	NN
cord-262445-54ng7m92	678	27	,	,	,
cord-262445-54ng7m92	678	28	analysing	analyse	VBG
cord-262445-54ng7m92	678	29	mice	mouse	NNS
cord-262445-54ng7m92	678	30	from	from	IN
cord-262445-54ng7m92	678	31	4	4	CD
cord-262445-54ng7m92	678	32	weeks	week	NNS
cord-262445-54ng7m92	678	33	of	of	IN
cord-262445-54ng7m92	678	34	age	age	NN
cord-262445-54ng7m92	678	35	up	up	IN
cord-262445-54ng7m92	678	36	to	to	TO
cord-262445-54ng7m92	678	37	11	11	CD
cord-262445-54ng7m92	678	38	months	month	NNS
cord-262445-54ng7m92	678	39	.	.	.
cord-262445-54ng7m92	679	1	Morphological	morphological	JJ
cord-262445-54ng7m92	679	2	analysis	analysis	NN
cord-262445-54ng7m92	679	3	on	on	IN
cord-262445-54ng7m92	679	4	muscle	muscle	NN
cord-262445-54ng7m92	679	5	fibrosis	fibrosis	NN
cord-262445-54ng7m92	679	6	,	,	,
cord-262445-54ng7m92	679	7	necrosis	necrosis	NN
cord-262445-54ng7m92	679	8	and	and	CC
cord-262445-54ng7m92	679	9	organization	organization	NN
cord-262445-54ng7m92	679	10	will	will	MD
cord-262445-54ng7m92	679	11	be	be	VB
cord-262445-54ng7m92	679	12	performed	perform	VBN
cord-262445-54ng7m92	679	13	,	,	,
cord-262445-54ng7m92	679	14	as	as	RB
cord-262445-54ng7m92	679	15	well	well	RB
cord-262445-54ng7m92	679	16	as	as	IN
cord-262445-54ng7m92	679	17	molecular	molecular	JJ
cord-262445-54ng7m92	679	18	analyses	analysis	NNS
cord-262445-54ng7m92	679	19	to	to	TO
cord-262445-54ng7m92	679	20	assess	assess	VB
cord-262445-54ng7m92	679	21	cytokines	cytokine	NNS
cord-262445-54ng7m92	679	22	levels	level	NNS
cord-262445-54ng7m92	679	23	and	and	CC
cord-262445-54ng7m92	679	24	fibrosis	fibrosis	NN
cord-262445-54ng7m92	679	25	markers	marker	NNS
cord-262445-54ng7m92	679	26	.	.	.
cord-262445-54ng7m92	680	1	Given	give	VBN
cord-262445-54ng7m92	680	2	that	that	IN
cord-262445-54ng7m92	680	3	mdx	mdx	NNP
cord-262445-54ng7m92	680	4	mice	mouse	NNS
cord-262445-54ng7m92	680	5	often	often	RB
cord-262445-54ng7m92	680	6	show	show	VBP
cord-262445-54ng7m92	680	7	a	a	DT
cord-262445-54ng7m92	680	8	poor	poor	JJ
cord-262445-54ng7m92	680	9	heart	heart	NN
cord-262445-54ng7m92	680	10	pathology	pathology	NN
cord-262445-54ng7m92	680	11	,	,	,
cord-262445-54ng7m92	680	12	we	-PRON-	PRP
cord-262445-54ng7m92	680	13	are	be	VBP
cord-262445-54ng7m92	680	14	currently	currently	RB
cord-262445-54ng7m92	680	15	defining	define	VBG
cord-262445-54ng7m92	680	16	an	an	DT
cord-262445-54ng7m92	680	17	exercise	exercise	NN
cord-262445-54ng7m92	680	18	protocol	protocol	NN
cord-262445-54ng7m92	680	19	in	in	IN
cord-262445-54ng7m92	680	20	order	order	NN
cord-262445-54ng7m92	680	21	to	to	TO
cord-262445-54ng7m92	680	22	worsen	worsen	VB
cord-262445-54ng7m92	680	23	the	the	DT
cord-262445-54ng7m92	680	24	dystrophic	dystrophic	JJ
cord-262445-54ng7m92	680	25	phenotype	phenotype	NN
cord-262445-54ng7m92	680	26	,	,	,
cord-262445-54ng7m92	680	27	in	in	IN
cord-262445-54ng7m92	680	28	order	order	NN
cord-262445-54ng7m92	680	29	to	to	TO
cord-262445-54ng7m92	680	30	mirror	mirror	VB
cord-262445-54ng7m92	680	31	the	the	DT
cord-262445-54ng7m92	680	32	human	human	JJ
cord-262445-54ng7m92	680	33	pathology	pathology	NN
cord-262445-54ng7m92	680	34	.	.	.
cord-262445-54ng7m92	681	1	The	the	DT
cord-262445-54ng7m92	681	2	data	datum	NNS
cord-262445-54ng7m92	681	3	we	-PRON-	PRP
cord-262445-54ng7m92	681	4	will	will	MD
cord-262445-54ng7m92	681	5	collect	collect	VB
cord-262445-54ng7m92	681	6	in	in	IN
cord-262445-54ng7m92	681	7	this	this	DT
cord-262445-54ng7m92	681	8	part	part	NN
cord-262445-54ng7m92	681	9	of	of	IN
cord-262445-54ng7m92	681	10	the	the	DT
cord-262445-54ng7m92	681	11	study	study	NN
cord-262445-54ng7m92	681	12	will	will	MD
cord-262445-54ng7m92	681	13	be	be	VB
cord-262445-54ng7m92	681	14	instrumental	instrumental	JJ
cord-262445-54ng7m92	681	15	to	to	TO
cord-262445-54ng7m92	681	16	design	design	VB
cord-262445-54ng7m92	681	17	new	new	JJ
cord-262445-54ng7m92	681	18	pharmacological	pharmacological	JJ
cord-262445-54ng7m92	681	19	treatments	treatment	NNS
cord-262445-54ng7m92	681	20	using	use	VBG
cord-262445-54ng7m92	681	21	specific	specific	JJ
cord-262445-54ng7m92	681	22	inhibitors	inhibitor	NNS
cord-262445-54ng7m92	681	23	(	(	-LRB-
cord-262445-54ng7m92	681	24	as	as	IN
cord-262445-54ng7m92	681	25	we	-PRON-	PRP
cord-262445-54ng7m92	681	26	did	do	VBD
cord-262445-54ng7m92	681	27	for	for	IN
cord-262445-54ng7m92	681	28	skeletal	skeletal	JJ
cord-262445-54ng7m92	681	29	muscle	muscle	NN
cord-262445-54ng7m92	681	30	)	)	-RRB-
cord-262445-54ng7m92	681	31	instead	instead	RB
cord-262445-54ng7m92	681	32	of	of	IN
cord-262445-54ng7m92	681	33	broad	broad	JJ
cord-262445-54ng7m92	681	34	-	-	HYPH
cord-262445-54ng7m92	681	35	spectrum	spectrum	NN
cord-262445-54ng7m92	681	36	anti	anti	JJ
cord-262445-54ng7m92	681	37	-	-	JJ
cord-262445-54ng7m92	681	38	inflammatory	inflammatory	JJ
cord-262445-54ng7m92	681	39	compounds	compound	NNS
cord-262445-54ng7m92	681	40	.	.	.
cord-262445-54ng7m92	682	1	We	-PRON-	PRP
cord-262445-54ng7m92	682	2	hope	hope	VBP
cord-262445-54ng7m92	682	3	that	that	IN
cord-262445-54ng7m92	682	4	our	-PRON-	PRP$
cord-262445-54ng7m92	682	5	study	study	NN
cord-262445-54ng7m92	682	6	will	will	MD
cord-262445-54ng7m92	682	7	help	help	VB
cord-262445-54ng7m92	682	8	developing	develop	VBG
cord-262445-54ng7m92	682	9	more	more	RBR
cord-262445-54ng7m92	682	10	effective	effective	JJ
cord-262445-54ng7m92	682	11	and	and	CC
cord-262445-54ng7m92	682	12	fine	fine	JJ
cord-262445-54ng7m92	682	13	targeted	targeted	JJ
cord-262445-54ng7m92	682	14	treatments	treatment	NNS
cord-262445-54ng7m92	682	15	,	,	,
cord-262445-54ng7m92	682	16	with	with	IN
cord-262445-54ng7m92	682	17	less	less	RBR
cord-262445-54ng7m92	682	18	adverse	adverse	JJ
cord-262445-54ng7m92	682	19	effects	effect	NNS
cord-262445-54ng7m92	682	20	for	for	IN
cord-262445-54ng7m92	682	21	patients	patient	NNS
cord-262445-54ng7m92	682	22	Thyroid	thyroid	JJ
cord-262445-54ng7m92	682	23	hormone	hormone	NN
cord-262445-54ng7m92	682	24	(	(	-LRB-
cord-262445-54ng7m92	682	25	TH	TH	NNP
cord-262445-54ng7m92	682	26	)	)	-RRB-
cord-262445-54ng7m92	682	27	has	have	VBZ
cord-262445-54ng7m92	682	28	a	a	DT
cord-262445-54ng7m92	682	29	major	major	JJ
cord-262445-54ng7m92	682	30	role	role	NN
cord-262445-54ng7m92	682	31	in	in	IN
cord-262445-54ng7m92	682	32	the	the	DT
cord-262445-54ng7m92	682	33	control	control	NN
cord-262445-54ng7m92	682	34	of	of	IN
cord-262445-54ng7m92	682	35	systemic	systemic	JJ
cord-262445-54ng7m92	682	36	metabolism	metabolism	NN
cord-262445-54ng7m92	682	37	,	,	,
cord-262445-54ng7m92	682	38	influencing	influence	VBG
cord-262445-54ng7m92	682	39	carbohydrate	carbohydrate	NN
cord-262445-54ng7m92	682	40	,	,	,
cord-262445-54ng7m92	682	41	protein	protein	NN
cord-262445-54ng7m92	682	42	and	and	CC
cord-262445-54ng7m92	682	43	lipid	lipid	NN
cord-262445-54ng7m92	682	44	metabolism	metabolism	NN
cord-262445-54ng7m92	682	45	.	.	.
cord-262445-54ng7m92	683	1	Moreover	moreover	RB
cord-262445-54ng7m92	683	2	,	,	,
cord-262445-54ng7m92	683	3	T3	T3	NNP
cord-262445-54ng7m92	683	4	regulates	regulate	VBZ
cord-262445-54ng7m92	683	5	mitochondrial	mitochondrial	JJ
cord-262445-54ng7m92	683	6	function	function	NN
cord-262445-54ng7m92	683	7	and	and	CC
cord-262445-54ng7m92	683	8	turnover	turnover	NN
cord-262445-54ng7m92	683	9	controlling	control	VBG
cord-262445-54ng7m92	683	10	mitochondrial	mitochondrial	JJ
cord-262445-54ng7m92	683	11	biogenesis	biogenesis	NN
cord-262445-54ng7m92	683	12	,	,	,
cord-262445-54ng7m92	683	13	proton	proton	NN
cord-262445-54ng7m92	683	14	leak	leak	NN
cord-262445-54ng7m92	683	15	,	,	,
cord-262445-54ng7m92	683	16	OXPHOS	OXPHOS	NNP
cord-262445-54ng7m92	683	17	and	and	CC
cord-262445-54ng7m92	683	18	ROS	ROS	NNP
cord-262445-54ng7m92	683	19	generation	generation	NN
cord-262445-54ng7m92	683	20	.	.	.
cord-262445-54ng7m92	684	1	The	the	DT
cord-262445-54ng7m92	684	2	deiodinases	deiodinase	NNS
cord-262445-54ng7m92	684	3	enzymes	enzyme	NNS
cord-262445-54ng7m92	684	4	enable	enable	VBP
cord-262445-54ng7m92	684	5	intracellular	intracellular	JJ
cord-262445-54ng7m92	684	6	TH	TH	NNP
cord-262445-54ng7m92	684	7	activation	activation	NN
cord-262445-54ng7m92	684	8	or	or	CC
cord-262445-54ng7m92	684	9	inactivation	inactivation	NN
cord-262445-54ng7m92	684	10	,	,	,
cord-262445-54ng7m92	684	11	regardless	regardless	RB
cord-262445-54ng7m92	684	12	of	of	IN
cord-262445-54ng7m92	684	13	circulating	circulate	VBG
cord-262445-54ng7m92	684	14	hormone	hormone	NN
cord-262445-54ng7m92	684	15	levels	level	NNS
cord-262445-54ng7m92	684	16	.	.	.
cord-262445-54ng7m92	685	1	To	to	TO
cord-262445-54ng7m92	685	2	address	address	VB
cord-262445-54ng7m92	685	3	the	the	DT
cord-262445-54ng7m92	685	4	physiological	physiological	JJ
cord-262445-54ng7m92	685	5	function	function	NN
cord-262445-54ng7m92	685	6	of	of	IN
cord-262445-54ng7m92	685	7	deiodinases	deiodinase	NNS
cord-262445-54ng7m92	685	8	in	in	IN
cord-262445-54ng7m92	685	9	skeletal	skeletal	JJ
cord-262445-54ng7m92	685	10	muscle	muscle	NN
cord-262445-54ng7m92	685	11	metabolism	metabolism	NN
cord-262445-54ng7m92	685	12	,	,	,
cord-262445-54ng7m92	685	13	we	-PRON-	PRP
cord-262445-54ng7m92	685	14	used	use	VBD
cord-262445-54ng7m92	685	15	muscle	muscle	NN
cord-262445-54ng7m92	685	16	-	-	HYPH
cord-262445-54ng7m92	685	17	specific	specific	JJ
cord-262445-54ng7m92	685	18	gain	gain	NN
cord-262445-54ng7m92	685	19	-	-	HYPH
cord-262445-54ng7m92	685	20	of	of	IN
cord-262445-54ng7m92	685	21	-	-	HYPH
cord-262445-54ng7m92	685	22	function	function	NN
cord-262445-54ng7m92	685	23	approaches	approach	NNS
cord-262445-54ng7m92	685	24	.	.	.
cord-262445-54ng7m92	686	1	Here	here	RB
cord-262445-54ng7m92	686	2	,	,	,
cord-262445-54ng7m92	686	3	we	-PRON-	PRP
cord-262445-54ng7m92	686	4	show	show	VBP
cord-262445-54ng7m92	686	5	that	that	IN
cord-262445-54ng7m92	686	6	muscle	muscle	NN
cord-262445-54ng7m92	686	7	-	-	HYPH
cord-262445-54ng7m92	686	8	specific	specific	JJ
cord-262445-54ng7m92	686	9	hypothyroidism	hypothyroidism	NN
cord-262445-54ng7m92	686	10	in	in	IN
cord-262445-54ng7m92	686	11	mice	mouse	NNS
cord-262445-54ng7m92	686	12	by	by	IN
cord-262445-54ng7m92	686	13	D3	D3	NNP
cord-262445-54ng7m92	686	14	overexpression	overexpression	NN
cord-262445-54ng7m92	686	15	(	(	-LRB-
cord-262445-54ng7m92	686	16	TG	TG	NNP
cord-262445-54ng7m92	686	17	-	-	HYPH
cord-262445-54ng7m92	686	18	D3	D3	NNP
cord-262445-54ng7m92	686	19	mice	mouse	NNS
cord-262445-54ng7m92	686	20	)	)	-RRB-
cord-262445-54ng7m92	686	21	induces	induce	VBZ
cord-262445-54ng7m92	686	22	a	a	DT
cord-262445-54ng7m92	686	23	metabolic	metabolic	JJ
cord-262445-54ng7m92	686	24	reprograming	reprograming	NN
cord-262445-54ng7m92	686	25	of	of	IN
cord-262445-54ng7m92	686	26	muscle	muscle	NN
cord-262445-54ng7m92	686	27	fibers	fiber	NNS
cord-262445-54ng7m92	686	28	reducing	reduce	VBG
cord-262445-54ng7m92	686	29	glycolytic	glycolytic	JJ
cord-262445-54ng7m92	686	30	and	and	CC
cord-262445-54ng7m92	686	31	lipid	lipid	NN
cord-262445-54ng7m92	686	32	metabolism	metabolism	NN
cord-262445-54ng7m92	686	33	.	.	.
cord-262445-54ng7m92	687	1	D3	D3	NNP
cord-262445-54ng7m92	687	2	overexpression	overexpression	NN
cord-262445-54ng7m92	687	3	in	in	IN
cord-262445-54ng7m92	687	4	muscle	muscle	NN
cord-262445-54ng7m92	687	5	also	also	RB
cord-262445-54ng7m92	687	6	reduces	reduce	VBZ
cord-262445-54ng7m92	687	7	mitochondrial	mitochondrial	JJ
cord-262445-54ng7m92	687	8	dynamics	dynamic	NNS
cord-262445-54ng7m92	687	9	.	.	.
cord-262445-54ng7m92	688	1	Immunofluorescence	immunofluorescence	NN
cord-262445-54ng7m92	688	2	analysis	analysis	NN
cord-262445-54ng7m92	688	3	revealed	reveal	VBD
cord-262445-54ng7m92	688	4	a	a	DT
cord-262445-54ng7m92	688	5	structural	structural	JJ
cord-262445-54ng7m92	688	6	alteration	alteration	NN
cord-262445-54ng7m92	688	7	of	of	IN
cord-262445-54ng7m92	688	8	mitochondria	mitochondrion	NNS
cord-262445-54ng7m92	688	9	.	.	.
cord-262445-54ng7m92	689	1	FACS	FACS	NNP
cord-262445-54ng7m92	689	2	analysis	analysis	NN
cord-262445-54ng7m92	689	3	highlighted	highlight	VBD
cord-262445-54ng7m92	689	4	a	a	DT
cord-262445-54ng7m92	689	5	reduced	reduce	VBN
cord-262445-54ng7m92	689	6	mitochondrial	mitochondrial	JJ
cord-262445-54ng7m92	689	7	density	density	NN
cord-262445-54ng7m92	689	8	with	with	IN
cord-262445-54ng7m92	689	9	increased	increase	VBN
cord-262445-54ng7m92	689	10	size	size	NN
cord-262445-54ng7m92	689	11	.	.	.
cord-262445-54ng7m92	690	1	However	however	RB
cord-262445-54ng7m92	690	2	,	,	,
cord-262445-54ng7m92	690	3	the	the	DT
cord-262445-54ng7m92	690	4	increased	increase	VBN
cord-262445-54ng7m92	690	5	mitochondrial	mitochondrial	JJ
cord-262445-54ng7m92	690	6	size	size	NN
cord-262445-54ng7m92	690	7	did	do	VBD
cord-262445-54ng7m92	690	8	not	not	RB
cord-262445-54ng7m92	690	9	correlate	correlate	VB
cord-262445-54ng7m92	690	10	with	with	IN
cord-262445-54ng7m92	690	11	increased	increase	VBN
cord-262445-54ng7m92	690	12	activity	activity	NN
cord-262445-54ng7m92	690	13	.	.	.
cord-262445-54ng7m92	691	1	Consistently	consistently	RB
cord-262445-54ng7m92	691	2	with	with	IN
cord-262445-54ng7m92	691	3	these	these	DT
cord-262445-54ng7m92	691	4	findings	finding	NNS
cord-262445-54ng7m92	691	5	,	,	,
cord-262445-54ng7m92	691	6	mitochondria	mitochondrion	NNS
cord-262445-54ng7m92	691	7	turnover	turnover	NN
cord-262445-54ng7m92	691	8	genes	gene	NNS
cord-262445-54ng7m92	691	9	DRP-1	DRP-1	NNP
cord-262445-54ng7m92	691	10	,	,	,
cord-262445-54ng7m92	691	11	MFN-1	MFN-1	NNP
cord-262445-54ng7m92	691	12	and	and	CC
cord-262445-54ng7m92	691	13	OPA-1	OPA-1	NNP
cord-262445-54ng7m92	691	14	,	,	,
cord-262445-54ng7m92	691	15	as	as	RB
cord-262445-54ng7m92	691	16	well	well	RB
cord-262445-54ng7m92	691	17	as	as	IN
cord-262445-54ng7m92	691	18	PGC-1α	PGC-1α	NNP
cord-262445-54ng7m92	691	19	,	,	,
cord-262445-54ng7m92	691	20	were	be	VBD
cord-262445-54ng7m92	691	21	reduced	reduce	VBN
cord-262445-54ng7m92	691	22	in	in	IN
cord-262445-54ng7m92	691	23	TG	TG	NNP
cord-262445-54ng7m92	691	24	-	-	HYPH
cord-262445-54ng7m92	691	25	D3	D3	NNP
cord-262445-54ng7m92	691	26	muscles	muscle	NNS
cord-262445-54ng7m92	691	27	.	.	.
cord-262445-54ng7m92	692	1	These	these	DT
cord-262445-54ng7m92	692	2	data	datum	NNS
cord-262445-54ng7m92	692	3	suggest	suggest	VBP
cord-262445-54ng7m92	692	4	that	that	IN
cord-262445-54ng7m92	692	5	metabolic	metabolic	JJ
cord-262445-54ng7m92	692	6	differences	difference	NNS
cord-262445-54ng7m92	692	7	between	between	IN
cord-262445-54ng7m92	692	8	TG	TG	NNP
cord-262445-54ng7m92	692	9	-	-	HYPH
cord-262445-54ng7m92	692	10	D3	D3	NNP
cord-262445-54ng7m92	692	11	and	and	CC
cord-262445-54ng7m92	692	12	control	control	NN
cord-262445-54ng7m92	692	13	muscles	muscle	NNS
cord-262445-54ng7m92	692	14	are	be	VBP
cord-262445-54ng7m92	692	15	associated	associate	VBN
cord-262445-54ng7m92	692	16	with	with	IN
cord-262445-54ng7m92	692	17	an	an	DT
cord-262445-54ng7m92	692	18	alteration	alteration	NN
cord-262445-54ng7m92	692	19	in	in	IN
cord-262445-54ng7m92	692	20	number	number	NN
cord-262445-54ng7m92	692	21	and	and	CC
cord-262445-54ng7m92	692	22	function	function	NN
cord-262445-54ng7m92	692	23	of	of	IN
cord-262445-54ng7m92	692	24	the	the	DT
cord-262445-54ng7m92	692	25	mitochondria	mitochondrion	NNS
cord-262445-54ng7m92	692	26	.	.	.
cord-262445-54ng7m92	693	1	Interestingly	interestingly	RB
cord-262445-54ng7m92	693	2	,	,	,
cord-262445-54ng7m92	693	3	the	the	DT
cord-262445-54ng7m92	693	4	overexpression	overexpression	NN
cord-262445-54ng7m92	693	5	of	of	IN
cord-262445-54ng7m92	693	6	PGC-1α	PGC-1α	NNP
cord-262445-54ng7m92	693	7	in	in	IN
cord-262445-54ng7m92	693	8	TG	TG	NNP
cord-262445-54ng7m92	693	9	-	-	HYPH
cord-262445-54ng7m92	693	10	D3	D3	NNP
cord-262445-54ng7m92	693	11	muscles	muscle	NNS
cord-262445-54ng7m92	693	12	rescued	rescue	VBD
cord-262445-54ng7m92	693	13	the	the	DT
cord-262445-54ng7m92	693	14	mitochondrial	mitochondrial	JJ
cord-262445-54ng7m92	693	15	defects	defect	NNS
cord-262445-54ng7m92	693	16	,	,	,
cord-262445-54ng7m92	693	17	reactivating	reactivate	VBG
cord-262445-54ng7m92	693	18	the	the	DT
cord-262445-54ng7m92	693	19	expression	expression	NN
cord-262445-54ng7m92	693	20	of	of	IN
cord-262445-54ng7m92	693	21	genes	gene	NNS
cord-262445-54ng7m92	693	22	involved	involve	VBN
cord-262445-54ng7m92	693	23	in	in	IN
cord-262445-54ng7m92	693	24	mitochondrial	mitochondrial	JJ
cord-262445-54ng7m92	693	25	fusion	fusion	NN
cord-262445-54ng7m92	693	26	and	and	CC
cord-262445-54ng7m92	693	27	fission	fission	NN
cord-262445-54ng7m92	693	28	.	.	.
cord-262445-54ng7m92	694	1	Altogether	altogether	RB
cord-262445-54ng7m92	694	2	these	these	DT
cord-262445-54ng7m92	694	3	results	result	NNS
cord-262445-54ng7m92	694	4	indicate	indicate	VBP
cord-262445-54ng7m92	694	5	that	that	IN
cord-262445-54ng7m92	694	6	the	the	DT
cord-262445-54ng7m92	694	7	mitochondrial	mitochondrial	JJ
cord-262445-54ng7m92	694	8	dysfunction	dysfunction	NN
cord-262445-54ng7m92	694	9	of	of	IN
cord-262445-54ng7m92	694	10	TG	TG	NNP
cord-262445-54ng7m92	694	11	-	-	HYPH
cord-262445-54ng7m92	694	12	D3	D3	NNP
cord-262445-54ng7m92	694	13	muscles	muscle	NNS
cord-262445-54ng7m92	694	14	is	be	VBZ
cord-262445-54ng7m92	694	15	mediated	mediate	VBN
cord-262445-54ng7m92	694	16	by	by	IN
cord-262445-54ng7m92	694	17	the	the	DT
cord-262445-54ng7m92	694	18	downregulation	downregulation	NN
cord-262445-54ng7m92	694	19	of	of	IN
cord-262445-54ng7m92	694	20	PGC-1α	PGC-1α	NNP
cord-262445-54ng7m92	694	21	,	,	,
cord-262445-54ng7m92	694	22	the	the	DT
cord-262445-54ng7m92	694	23	master	master	NN
cord-262445-54ng7m92	694	24	regulator	regulator	NN
cord-262445-54ng7m92	694	25	of	of	IN
cord-262445-54ng7m92	694	26	mitochondrial	mitochondrial	JJ
cord-262445-54ng7m92	694	27	biogenesis	biogenesis	NN
cord-262445-54ng7m92	694	28	.	.	.
cord-262445-54ng7m92	695	1	Our	-PRON-	PRP$
cord-262445-54ng7m92	695	2	findings	finding	NNS
cord-262445-54ng7m92	695	3	indicate	indicate	VBP
cord-262445-54ng7m92	695	4	that	that	IN
cord-262445-54ng7m92	695	5	muscle	muscle	NN
cord-262445-54ng7m92	695	6	-	-	HYPH
cord-262445-54ng7m92	695	7	specific	specific	JJ
cord-262445-54ng7m92	695	8	hypothyroidism	hypothyroidism	NN
cord-262445-54ng7m92	695	9	via	via	IN
cord-262445-54ng7m92	695	10	D3	D3	NNP
cord-262445-54ng7m92	695	11	overexpression	overexpression	NN
cord-262445-54ng7m92	695	12	potently	potently	RB
cord-262445-54ng7m92	695	13	impacts	impact	VBZ
cord-262445-54ng7m92	695	14	on	on	IN
cord-262445-54ng7m92	695	15	mitochondrial	mitochondrial	JJ
cord-262445-54ng7m92	695	16	metabolism	metabolism	NN
cord-262445-54ng7m92	695	17	,	,	,
cord-262445-54ng7m92	695	18	identifying	identify	VBG
cord-262445-54ng7m92	695	19	the	the	DT
cord-262445-54ng7m92	695	20	deiodinases	deiodinase	NNS
cord-262445-54ng7m92	695	21	as	as	IN
cord-262445-54ng7m92	695	22	critical	critical	JJ
cord-262445-54ng7m92	695	23	metabolic	metabolic	JJ
cord-262445-54ng7m92	695	24	regulators	regulator	NNS
cord-262445-54ng7m92	695	25	.	.	.
cord-262445-54ng7m92	696	1	Understanding	understand	VBG
cord-262445-54ng7m92	696	2	the	the	DT
cord-262445-54ng7m92	696	3	mechanisms	mechanism	NNS
cord-262445-54ng7m92	696	4	of	of	IN
cord-262445-54ng7m92	696	5	action	action	NN
cord-262445-54ng7m92	696	6	of	of	IN
cord-262445-54ng7m92	696	7	deiodinases	deiodinase	NNS
cord-262445-54ng7m92	696	8	in	in	IN
cord-262445-54ng7m92	696	9	metabolism	metabolism	NN
cord-262445-54ng7m92	696	10	might	may	MD
cord-262445-54ng7m92	696	11	be	be	VB
cord-262445-54ng7m92	696	12	relevant	relevant	JJ
cord-262445-54ng7m92	696	13	for	for	IN
cord-262445-54ng7m92	696	14	therapeutic	therapeutic	JJ
cord-262445-54ng7m92	696	15	treatment	treatment	NN
cord-262445-54ng7m92	696	16	of	of	IN
cord-262445-54ng7m92	696	17	metabolic	metabolic	JJ
cord-262445-54ng7m92	696	18	disorders	disorder	NNS
cord-262445-54ng7m92	696	19	.	.	.
cord-262445-54ng7m92	697	1	Background	background	NN
cord-262445-54ng7m92	697	2	:	:	:
cord-262445-54ng7m92	698	1	Physical	physical	JJ
cord-262445-54ng7m92	698	2	activity	activity	NN
cord-262445-54ng7m92	698	3	ameliorates	ameliorate	VBZ
cord-262445-54ng7m92	698	4	the	the	DT
cord-262445-54ng7m92	698	5	prognosis	prognosis	NN
cord-262445-54ng7m92	698	6	of	of	IN
cord-262445-54ng7m92	698	7	cancer	cancer	NN
cord-262445-54ng7m92	698	8	patients	patient	NNS
cord-262445-54ng7m92	698	9	,	,	,
cord-262445-54ng7m92	698	10	also	also	RB
cord-262445-54ng7m92	698	11	by	by	IN
cord-262445-54ng7m92	698	12	contrasting	contrast	VBG
cord-262445-54ng7m92	698	13	the	the	DT
cord-262445-54ng7m92	698	14	associated	associate	VBN
cord-262445-54ng7m92	698	15	muscle	muscle	NN
cord-262445-54ng7m92	698	16	wasting	wasting	NN
cord-262445-54ng7m92	698	17	(	(	-LRB-
cord-262445-54ng7m92	698	18	i.e.	i.e.	FW
cord-262445-54ng7m92	698	19	cachexia	cachexia	NN
cord-262445-54ng7m92	698	20	)	)	-RRB-
cord-262445-54ng7m92	698	21	.	.	.
cord-262445-54ng7m92	699	1	Since	since	IN
cord-262445-54ng7m92	699	2	aerobic	aerobic	JJ
cord-262445-54ng7m92	699	3	exercise	exercise	NN
cord-262445-54ng7m92	699	4	seems	seem	VBZ
cord-262445-54ng7m92	699	5	to	to	TO
cord-262445-54ng7m92	699	6	be	be	VB
cord-262445-54ng7m92	699	7	the	the	DT
cord-262445-54ng7m92	699	8	most	most	RBS
cord-262445-54ng7m92	699	9	effective	effective	JJ
cord-262445-54ng7m92	699	10	to	to	TO
cord-262445-54ng7m92	699	11	preserve	preserve	VB
cord-262445-54ng7m92	699	12	muscles	muscle	NNS
cord-262445-54ng7m92	699	13	during	during	IN
cord-262445-54ng7m92	699	14	cancer	cancer	NN
cord-262445-54ng7m92	699	15	,	,	,
cord-262445-54ng7m92	699	16	we	-PRON-	PRP
cord-262445-54ng7m92	699	17	asked	ask	VBD
cord-262445-54ng7m92	699	18	whether	whether	IN
cord-262445-54ng7m92	699	19	it	-PRON-	PRP
cord-262445-54ng7m92	699	20	promotes	promote	VBZ
cord-262445-54ng7m92	699	21	secretion	secretion	NN
cord-262445-54ng7m92	699	22	of	of	IN
cord-262445-54ng7m92	699	23	proteins	protein	NNS
cord-262445-54ng7m92	699	24	by	by	IN
cord-262445-54ng7m92	699	25	muscles	muscle	NNS
cord-262445-54ng7m92	699	26	(	(	-LRB-
cord-262445-54ng7m92	699	27	i.e.	i.e.	FW
cord-262445-54ng7m92	699	28	myokines	myokines	NNP
cord-262445-54ng7m92	699	29	)	)	-RRB-
cord-262445-54ng7m92	699	30	that	that	WDT
cord-262445-54ng7m92	699	31	may	may	MD
cord-262445-54ng7m92	699	32	contrast	contrast	VB
cord-262445-54ng7m92	699	33	cachexia	cachexia	NN
cord-262445-54ng7m92	699	34	.	.	.
cord-262445-54ng7m92	700	1	Methods	method	NNS
cord-262445-54ng7m92	700	2	:	:	:
cord-262445-54ng7m92	700	3	To	to	TO
cord-262445-54ng7m92	700	4	mimic	mimic	VB
cord-262445-54ng7m92	700	5	aerobic	aerobic	JJ
cord-262445-54ng7m92	700	6	exercise	exercise	NN
cord-262445-54ng7m92	700	7	,	,	,
cord-262445-54ng7m92	700	8	we	-PRON-	PRP
cord-262445-54ng7m92	700	9	infected	infect	VBD
cord-262445-54ng7m92	700	10	C2C12	c2c12	JJ
cord-262445-54ng7m92	700	11	myotubes	myotube	NNS
cord-262445-54ng7m92	700	12	with	with	IN
cord-262445-54ng7m92	700	13	PGC1α	PGC1α	NNP
cord-262445-54ng7m92	700	14	expressing	express	VBG
cord-262445-54ng7m92	700	15	adenoviruses	adenovirus	NNS
cord-262445-54ng7m92	700	16	.	.	.
cord-262445-54ng7m92	701	1	In	in	IN
cord-262445-54ng7m92	701	2	vitro	vitro	FW
cord-262445-54ng7m92	701	3	we	-PRON-	PRP
cord-262445-54ng7m92	701	4	evaluated	evaluate	VBD
cord-262445-54ng7m92	701	5	the	the	DT
cord-262445-54ng7m92	701	6	effects	effect	NNS
cord-262445-54ng7m92	701	7	of	of	IN
cord-262445-54ng7m92	701	8	supernatants	supernatant	NNS
cord-262445-54ng7m92	701	9	from	from	IN
cord-262445-54ng7m92	701	10	GFP	GFP	NNP
cord-262445-54ng7m92	701	11	or	or	CC
cord-262445-54ng7m92	701	12	PGC1α	PGC1α	NNP
cord-262445-54ng7m92	701	13	-	-	HYPH
cord-262445-54ng7m92	701	14	overexpressing	overexpresse	VBG
cord-262445-54ng7m92	701	15	cells	cell	NNS
cord-262445-54ng7m92	701	16	on	on	IN
cord-262445-54ng7m92	701	17	protein	protein	NN
cord-262445-54ng7m92	701	18	synthesis	synthesis	NN
cord-262445-54ng7m92	701	19	and	and	CC
cord-262445-54ng7m92	701	20	degradation	degradation	NN
cord-262445-54ng7m92	701	21	of	of	IN
cord-262445-54ng7m92	701	22	atrophying	atrophy	VBG
cord-262445-54ng7m92	701	23	myotubes	myotube	NNS
cord-262445-54ng7m92	701	24	and	and	CC
cord-262445-54ng7m92	701	25	in	in	IN
cord-262445-54ng7m92	701	26	LucAssay	LucAssay	NNP
cord-262445-54ng7m92	701	27	.	.	.
cord-262445-54ng7m92	702	1	By	by	IN
cord-262445-54ng7m92	702	2	microarray	microarray	NN
cord-262445-54ng7m92	702	3	,	,	,
cord-262445-54ng7m92	702	4	we	-PRON-	PRP
cord-262445-54ng7m92	702	5	identified	identify	VBD
cord-262445-54ng7m92	702	6	putatively	putatively	RB
cord-262445-54ng7m92	702	7	secreted	secrete	VBN
cord-262445-54ng7m92	702	8	proteins	protein	NNS
cord-262445-54ng7m92	702	9	inducible	inducible	JJ
cord-262445-54ng7m92	702	10	by	by	IN
cord-262445-54ng7m92	702	11	PGC1α	PGC1α	NNP
cord-262445-54ng7m92	702	12	and	and	CC
cord-262445-54ng7m92	702	13	confirmed	confirm	VBN
cord-262445-54ng7m92	702	14	by	by	IN
cord-262445-54ng7m92	702	15	Q	Q	NNP
cord-262445-54ng7m92	702	16	-	-	HYPH
cord-262445-54ng7m92	702	17	PCR	PCR	NNP
cord-262445-54ng7m92	702	18	.	.	.
cord-262445-54ng7m92	703	1	We	-PRON-	PRP
cord-262445-54ng7m92	703	2	measured	measure	VBN
cord-262445-54ng7m92	703	3	by	by	IN
cord-262445-54ng7m92	703	4	Q	Q	NNP
cord-262445-54ng7m92	703	5	-	-	HYPH
cord-262445-54ng7m92	703	6	PCR	PCR	NNP
cord-262445-54ng7m92	703	7	their	-PRON-	PRP$
cord-262445-54ng7m92	703	8	expression	expression	NN
cord-262445-54ng7m92	703	9	in	in	IN
cord-262445-54ng7m92	703	10	Tibialis	Tibialis	NNP
cord-262445-54ng7m92	703	11	Anterior	Anterior	NNP
cord-262445-54ng7m92	703	12	(	(	-LRB-
cord-262445-54ng7m92	703	13	TA	TA	NNP
cord-262445-54ng7m92	703	14	)	)	-RRB-
cord-262445-54ng7m92	703	15	muscle	muscle	NN
cord-262445-54ng7m92	703	16	of	of	IN
cord-262445-54ng7m92	703	17	C26-bearing	C26-bearing	NNP
cord-262445-54ng7m92	703	18	mice	mouse	NNS
cord-262445-54ng7m92	703	19	during	during	IN
cord-262445-54ng7m92	703	20	cachexia	cachexia	NN
cord-262445-54ng7m92	703	21	and	and	CC
cord-262445-54ng7m92	703	22	plasma	plasma	NN
cord-262445-54ng7m92	703	23	levels	level	NNS
cord-262445-54ng7m92	703	24	by	by	IN
cord-262445-54ng7m92	703	25	ELISA	ELISA	NNP
cord-262445-54ng7m92	703	26	.	.	.
cord-262445-54ng7m92	704	1	To	to	TO
cord-262445-54ng7m92	704	2	induce	induce	VB
cord-262445-54ng7m92	704	3	aerobic	aerobic	JJ
cord-262445-54ng7m92	704	4	exercise	exercise	NN
cord-262445-54ng7m92	704	5	adaptations	adaptation	NNS
cord-262445-54ng7m92	704	6	,	,	,
cord-262445-54ng7m92	704	7	mice	mouse	NNS
cord-262445-54ng7m92	704	8	were	be	VBD
cord-262445-54ng7m92	704	9	run	run	VBN
cord-262445-54ng7m92	704	10	on	on	IN
cord-262445-54ng7m92	704	11	treadmill	treadmill	NN
cord-262445-54ng7m92	704	12	.	.	.
cord-262445-54ng7m92	705	1	Anaerobic	anaerobic	JJ
cord-262445-54ng7m92	705	2	exercise	exercise	NN
cord-262445-54ng7m92	705	3	-	-	HYPH
cord-262445-54ng7m92	705	4	like	like	JJ
cord-262445-54ng7m92	705	5	effects	effect	NNS
cord-262445-54ng7m92	705	6	were	be	VBD
cord-262445-54ng7m92	705	7	obtained	obtain	VBN
cord-262445-54ng7m92	705	8	in	in	IN
cord-262445-54ng7m92	705	9	vivo	vivo	NN
cord-262445-54ng7m92	705	10	in	in	IN
cord-262445-54ng7m92	705	11	overloaded	overloaded	JJ
cord-262445-54ng7m92	705	12	Plantaris	Plantaris	NNP
cord-262445-54ng7m92	705	13	muscle	muscle	NN
cord-262445-54ng7m92	705	14	and	and	CC
cord-262445-54ng7m92	705	15	in	in	IN
cord-262445-54ng7m92	705	16	vitro	vitro	FW
cord-262445-54ng7m92	705	17	in	in	IN
cord-262445-54ng7m92	705	18	myotubes	myotubes	NNP
cord-262445-54ng7m92	705	19	expressing	express	VBG
cord-262445-54ng7m92	705	20	myristoylated	myristoylate	VBN
cord-262445-54ng7m92	705	21	AKT	AKT	NNP
cord-262445-54ng7m92	705	22	.	.	.
cord-262445-54ng7m92	706	1	Results	result	NNS
cord-262445-54ng7m92	706	2	:	:	:
cord-262445-54ng7m92	707	1	Our	-PRON-	PRP$
cord-262445-54ng7m92	707	2	microarray	microarray	NN
cord-262445-54ng7m92	707	3	and	and	CC
cord-262445-54ng7m92	707	4	Q	q	NN
cord-262445-54ng7m92	707	5	-	-	HYPH
cord-262445-54ng7m92	707	6	PCR	PCR	NNP
cord-262445-54ng7m92	707	7	analyses	analysis	NNS
cord-262445-54ng7m92	707	8	showed	show	VBD
cord-262445-54ng7m92	707	9	musclin	musclin	NNP
cord-262445-54ng7m92	707	10	as	as	IN
cord-262445-54ng7m92	707	11	a	a	DT
cord-262445-54ng7m92	707	12	PGC1α	PGC1α	NNP
cord-262445-54ng7m92	707	13	-	-	HYPH
cord-262445-54ng7m92	707	14	induced	induce	VBN
cord-262445-54ng7m92	707	15	myokine	myokine	NN
cord-262445-54ng7m92	707	16	.	.	.
cord-262445-54ng7m92	708	1	Conversely	conversely	RB
cord-262445-54ng7m92	708	2	,	,	,
cord-262445-54ng7m92	708	3	its	-PRON-	PRP$
cord-262445-54ng7m92	708	4	expression	expression	NN
cord-262445-54ng7m92	708	5	was	be	VBD
cord-262445-54ng7m92	708	6	unchanged	unchanged	JJ
cord-262445-54ng7m92	708	7	in	in	IN
cord-262445-54ng7m92	708	8	myotubes	myotubes	NNP
cord-262445-54ng7m92	708	9	hypertrophying	hypertrophying	NN
cord-262445-54ng7m92	708	10	because	because	IN
cord-262445-54ng7m92	708	11	of	of	IN
cord-262445-54ng7m92	708	12	activated	activate	VBN
cord-262445-54ng7m92	708	13	AKT	AKT	NNP
cord-262445-54ng7m92	708	14	.	.	.
cord-262445-54ng7m92	709	1	Dexamethazone	Dexamethazone	NNP
cord-262445-54ng7m92	709	2	-	-	HYPH
cord-262445-54ng7m92	709	3	treated	treat	VBN
cord-262445-54ng7m92	709	4	myotubes	myotube	NNS
cord-262445-54ng7m92	709	5	or	or	CC
cord-262445-54ng7m92	709	6	constitutively	constitutively	RB
cord-262445-54ng7m92	709	7	active	active	JJ
cord-262445-54ng7m92	710	1	(	(	-LRB-
cord-262445-54ng7m92	710	2	ca)FoxO3-expressing	ca)foxo3-expressing	NN
cord-262445-54ng7m92	710	3	ones	one	NNS
cord-262445-54ng7m92	710	4	undergo	undergo	VBP
cord-262445-54ng7m92	710	5	atrophy	atrophy	NN
cord-262445-54ng7m92	710	6	as	as	IN
cord-262445-54ng7m92	710	7	measured	measure	VBN
cord-262445-54ng7m92	710	8	by	by	IN
cord-262445-54ng7m92	710	9	increased	increase	VBN
cord-262445-54ng7m92	710	10	proteolysis	proteolysis	NN
cord-262445-54ng7m92	710	11	and	and	CC
cord-262445-54ng7m92	710	12	MuRF1	MuRF1	NNP
cord-262445-54ng7m92	710	13	induction	induction	NN
cord-262445-54ng7m92	710	14	.	.	.
cord-262445-54ng7m92	711	1	Unlike	unlike	IN
cord-262445-54ng7m92	711	2	to	to	IN
cord-262445-54ng7m92	711	3	GFP	GFP	NNP
cord-262445-54ng7m92	711	4	,	,	,
cord-262445-54ng7m92	711	5	musclin	musclin	NNP
cord-262445-54ng7m92	711	6	restrained	restrain	VBD
cord-262445-54ng7m92	711	7	the	the	DT
cord-262445-54ng7m92	711	8	dexamethazone	dexamethazone	NN
cord-262445-54ng7m92	711	9	-	-	HYPH
cord-262445-54ng7m92	711	10	induced	induce	VBN
cord-262445-54ng7m92	711	11	MuRF1	MuRF1	NNP
cord-262445-54ng7m92	711	12	expression	expression	NN
cord-262445-54ng7m92	711	13	in	in	IN
cord-262445-54ng7m92	711	14	Luciferase	Luciferase	NNP
cord-262445-54ng7m92	711	15	assays	assay	NNS
cord-262445-54ng7m92	711	16	.	.	.
cord-262445-54ng7m92	712	1	Consistently	consistently	RB
cord-262445-54ng7m92	712	2	,	,	,
cord-262445-54ng7m92	712	3	musclin	musclin	NNP
cord-262445-54ng7m92	712	4	-	-	HYPH
cord-262445-54ng7m92	712	5	containing	contain	VBG
cord-262445-54ng7m92	712	6	supernatants	supernatant	NNS
cord-262445-54ng7m92	712	7	reduced	reduce	VBD
cord-262445-54ng7m92	712	8	the	the	DT
cord-262445-54ng7m92	712	9	caFoxO3-induced	cafoxo3-induce	VBN
cord-262445-54ng7m92	712	10	rates	rate	NNS
cord-262445-54ng7m92	712	11	of	of	IN
cord-262445-54ng7m92	712	12	long	long	RB
cord-262445-54ng7m92	712	13	-	-	HYPH
cord-262445-54ng7m92	712	14	lived	live	VBN
cord-262445-54ng7m92	712	15	protein	protein	NN
cord-262445-54ng7m92	712	16	degradation	degradation	NN
cord-262445-54ng7m92	712	17	.	.	.
cord-262445-54ng7m92	713	1	Among	among	IN
cord-262445-54ng7m92	713	2	the	the	DT
cord-262445-54ng7m92	713	3	newly	newly	RB
cord-262445-54ng7m92	713	4	identified	identify	VBN
cord-262445-54ng7m92	713	5	PGC1α	PGC1α	NNP
cord-262445-54ng7m92	713	6	-	-	HYPH
cord-262445-54ng7m92	713	7	induced	induce	VBN
cord-262445-54ng7m92	713	8	myokines	myokine	NNS
cord-262445-54ng7m92	713	9	,	,	,
cord-262445-54ng7m92	713	10	we	-PRON-	PRP
cord-262445-54ng7m92	713	11	found	find	VBD
cord-262445-54ng7m92	713	12	that	that	IN
cord-262445-54ng7m92	713	13	-47	-47	NNP
cord-262445-54ng7m92	713	14	-only	-only	NNP
cord-262445-54ng7m92	713	15	musclin	musclin	NNP
cord-262445-54ng7m92	713	16	(	(	-LRB-
cord-262445-54ng7m92	713	17	and	and	CC
cord-262445-54ng7m92	713	18	its	-PRON-	PRP$
cord-262445-54ng7m92	713	19	receptor	receptor	NN
cord-262445-54ng7m92	713	20	Npr3	Npr3	NNP
cord-262445-54ng7m92	713	21	)	)	-RRB-
cord-262445-54ng7m92	713	22	was	be	VBD
cord-262445-54ng7m92	713	23	strongly	strongly	RB
cord-262445-54ng7m92	713	24	downregulated	downregulate	VBN
cord-262445-54ng7m92	713	25	in	in	IN
cord-262445-54ng7m92	713	26	cachectic	cachectic	JJ
cord-262445-54ng7m92	713	27	muscles	muscle	NNS
cord-262445-54ng7m92	713	28	and	and	CC
cord-262445-54ng7m92	713	29	plasma	plasma	NN
cord-262445-54ng7m92	713	30	of	of	IN
cord-262445-54ng7m92	713	31	C26bearing	C26bearing	NNP
cord-262445-54ng7m92	713	32	mice	mouse	NNS
cord-262445-54ng7m92	713	33	.	.	.
cord-262445-54ng7m92	714	1	Thus	thus	RB
cord-262445-54ng7m92	714	2	,	,	,
cord-262445-54ng7m92	714	3	we	-PRON-	PRP
cord-262445-54ng7m92	714	4	electroporated	electroporate	VBD
cord-262445-54ng7m92	714	5	TA	TA	NNP
cord-262445-54ng7m92	714	6	of	of	IN
cord-262445-54ng7m92	714	7	C26-bearing	C26-bearing	NNP
cord-262445-54ng7m92	714	8	mice	mouse	NNS
cord-262445-54ng7m92	714	9	with	with	IN
cord-262445-54ng7m92	714	10	musclin	musclin	NNP
cord-262445-54ng7m92	714	11	or	or	CC
cord-262445-54ng7m92	714	12	Npr3-encoding	npr3-encode	VBG
cord-262445-54ng7m92	714	13	plasmids	plasmid	NNS
cord-262445-54ng7m92	714	14	and	and	CC
cord-262445-54ng7m92	714	15	found	find	VBN
cord-262445-54ng7m92	714	16	either	either	CC
cord-262445-54ng7m92	714	17	musclin	musclin	NNP
cord-262445-54ng7m92	714	18	or	or	CC
cord-262445-54ng7m92	714	19	Npr3	Npr3	NNP
cord-262445-54ng7m92	714	20	to	to	TO
cord-262445-54ng7m92	714	21	preserve	preserve	VB
cord-262445-54ng7m92	714	22	fiber	fiber	NN
cord-262445-54ng7m92	714	23	area	area	NN
cord-262445-54ng7m92	714	24	.	.	.
cord-262445-54ng7m92	715	1	Interestingly	interestingly	RB
cord-262445-54ng7m92	715	2	,	,	,
cord-262445-54ng7m92	715	3	treadmill	treadmill	NN
cord-262445-54ng7m92	715	4	exercise	exercise	NN
cord-262445-54ng7m92	715	5	protected	protect	VBN
cord-262445-54ng7m92	715	6	C26-bearing	C26-bearing	NNP
cord-262445-54ng7m92	715	7	mice	mouse	NNS
cord-262445-54ng7m92	715	8	from	from	IN
cord-262445-54ng7m92	715	9	muscle	muscle	NN
cord-262445-54ng7m92	715	10	loss	loss	NN
cord-262445-54ng7m92	715	11	,	,	,
cord-262445-54ng7m92	715	12	with	with	IN
cord-262445-54ng7m92	715	13	no	no	DT
cord-262445-54ng7m92	715	14	effect	effect	NN
cord-262445-54ng7m92	715	15	on	on	IN
cord-262445-54ng7m92	715	16	tumor	tumor	NN
cord-262445-54ng7m92	715	17	growth	growth	NN
cord-262445-54ng7m92	715	18	,	,	,
cord-262445-54ng7m92	715	19	and	and	CC
cord-262445-54ng7m92	715	20	rescued	rescue	VBD
cord-262445-54ng7m92	715	21	the	the	DT
cord-262445-54ng7m92	715	22	C26-induced	C26-induced	NNP
cord-262445-54ng7m92	715	23	downregulation	downregulation	NN
cord-262445-54ng7m92	715	24	of	of	IN
cord-262445-54ng7m92	715	25	musclin	musclin	NNP
cord-262445-54ng7m92	715	26	in	in	IN
cord-262445-54ng7m92	715	27	muscles	muscle	NNS
cord-262445-54ng7m92	715	28	and	and	CC
cord-262445-54ng7m92	715	29	plasma	plasma	NN
cord-262445-54ng7m92	715	30	.	.	.
cord-262445-54ng7m92	716	1	By	by	IN
cord-262445-54ng7m92	716	2	contrast	contrast	NN
cord-262445-54ng7m92	716	3	,	,	,
cord-262445-54ng7m92	716	4	musclin	musclin	NNP
cord-262445-54ng7m92	716	5	expression	expression	NN
cord-262445-54ng7m92	716	6	did	do	VBD
cord-262445-54ng7m92	716	7	not	not	RB
cord-262445-54ng7m92	716	8	change	change	VB
cord-262445-54ng7m92	716	9	in	in	IN
cord-262445-54ng7m92	716	10	overloaded	overloaded	JJ
cord-262445-54ng7m92	716	11	Plantaris	Plantaris	NNP
cord-262445-54ng7m92	716	12	of	of	IN
cord-262445-54ng7m92	716	13	adult	adult	NN
cord-262445-54ng7m92	716	14	mice	mouse	NNS
cord-262445-54ng7m92	716	15	.	.	.
cord-262445-54ng7m92	717	1	Conclusions	conclusion	NNS
cord-262445-54ng7m92	717	2	:	:	:
cord-262445-54ng7m92	718	1	Musclin	Musclin	NNP
cord-262445-54ng7m92	718	2	is	be	VBZ
cord-262445-54ng7m92	718	3	a	a	DT
cord-262445-54ng7m92	718	4	myokine	myokine	NN
cord-262445-54ng7m92	718	5	induced	induce	VBN
cord-262445-54ng7m92	718	6	specifically	specifically	RB
cord-262445-54ng7m92	718	7	by	by	IN
cord-262445-54ng7m92	718	8	PGC1α	PGC1α	NNP
cord-262445-54ng7m92	718	9	,	,	,
cord-262445-54ng7m92	718	10	typically	typically	RB
cord-262445-54ng7m92	718	11	increased	increase	VBN
cord-262445-54ng7m92	718	12	upon	upon	IN
cord-262445-54ng7m92	718	13	aerobic	aerobic	JJ
cord-262445-54ng7m92	718	14	exercise	exercise	NN
cord-262445-54ng7m92	718	15	and	and	CC
cord-262445-54ng7m92	718	16	preserves	preserve	VBZ
cord-262445-54ng7m92	718	17	muscles	muscle	NNS
cord-262445-54ng7m92	718	18	from	from	IN
cord-262445-54ng7m92	718	19	wasting	waste	VBG
cord-262445-54ng7m92	718	20	during	during	IN
cord-262445-54ng7m92	718	21	C26	C26	NNP
cord-262445-54ng7m92	718	22	growth	growth	NN
cord-262445-54ng7m92	718	23	or	or	CC
cord-262445-54ng7m92	718	24	myotubes	myotube	NNS
cord-262445-54ng7m92	718	25	from	from	IN
cord-262445-54ng7m92	718	26	atrophy	atrophy	NN
cord-262445-54ng7m92	718	27	.	.	.
cord-262445-54ng7m92	719	1	Overall	overall	RB
cord-262445-54ng7m92	719	2	,	,	,
cord-262445-54ng7m92	719	3	musclin	musclin	NNP
cord-262445-54ng7m92	719	4	could	could	MD
cord-262445-54ng7m92	719	5	be	be	VB
cord-262445-54ng7m92	719	6	beneficial	beneficial	JJ
cord-262445-54ng7m92	719	7	to	to	IN
cord-262445-54ng7m92	719	8	cancer	cancer	NN
cord-262445-54ng7m92	719	9	patients	patient	NNS
cord-262445-54ng7m92	719	10	that	that	WDT
cord-262445-54ng7m92	719	11	can	can	MD
cord-262445-54ng7m92	719	12	not	not	RB
cord-262445-54ng7m92	719	13	exercise	exercise	VB
cord-262445-54ng7m92	719	14	and	and	CC
cord-262445-54ng7m92	719	15	are	be	VBP
cord-262445-54ng7m92	719	16	at	at	IN
cord-262445-54ng7m92	719	17	risk	risk	NN
cord-262445-54ng7m92	719	18	of	of	IN
cord-262445-54ng7m92	719	19	developing	develop	VBG
cord-262445-54ng7m92	719	20	cachexia	cachexia	NN
cord-262445-54ng7m92	719	21	.	.	.
cord-262445-54ng7m92	720	1	Reconstruction	reconstruction	NN
cord-262445-54ng7m92	720	2	of	of	IN
cord-262445-54ng7m92	720	3	the	the	DT
cord-262445-54ng7m92	720	4	skeletal	skeletal	JJ
cord-262445-54ng7m92	720	5	muscle	muscle	NN
cord-262445-54ng7m92	720	6	tissues	tissue	NNS
cord-262445-54ng7m92	720	7	after	after	IN
cord-262445-54ng7m92	720	8	damage	damage	NN
cord-262445-54ng7m92	720	9	relies	rely	VBZ
cord-262445-54ng7m92	720	10	on	on	IN
cord-262445-54ng7m92	720	11	the	the	DT
cord-262445-54ng7m92	720	12	activation	activation	NN
cord-262445-54ng7m92	720	13	of	of	IN
cord-262445-54ng7m92	720	14	Satellite	Satellite	NNP
cord-262445-54ng7m92	720	15	Cells	Cells	NNPS
cord-262445-54ng7m92	720	16	(	(	-LRB-
cord-262445-54ng7m92	720	17	SCs	SCs	NNP
cord-262445-54ng7m92	720	18	)	)	-RRB-
cord-262445-54ng7m92	720	19	,	,	,
cord-262445-54ng7m92	720	20	a	a	DT
cord-262445-54ng7m92	720	21	population	population	NN
cord-262445-54ng7m92	720	22	of	of	IN
cord-262445-54ng7m92	720	23	resident	resident	JJ
cord-262445-54ng7m92	720	24	muscle	muscle	NN
cord-262445-54ng7m92	720	25	stem	stem	NN
cord-262445-54ng7m92	720	26	cells	cell	NNS
cord-262445-54ng7m92	720	27	.	.	.
cord-262445-54ng7m92	721	1	Several	several	JJ
cord-262445-54ng7m92	721	2	transcription	transcription	NN
cord-262445-54ng7m92	721	3	factors	factor	NNS
cord-262445-54ng7m92	721	4	are	be	VBP
cord-262445-54ng7m92	721	5	involved	involve	VBN
cord-262445-54ng7m92	721	6	in	in	IN
cord-262445-54ng7m92	721	7	SCs	SCs	NNP
cord-262445-54ng7m92	721	8	activation	activation	NN
cord-262445-54ng7m92	721	9	and	and	CC
cord-262445-54ng7m92	721	10	proliferation	proliferation	NN
cord-262445-54ng7m92	721	11	and	and	CC
cord-262445-54ng7m92	721	12	ensure	ensure	VB
cord-262445-54ng7m92	721	13	proper	proper	JJ
cord-262445-54ng7m92	721	14	temporal	temporal	JJ
cord-262445-54ng7m92	721	15	and	and	CC
cord-262445-54ng7m92	721	16	spatial	spatial	JJ
cord-262445-54ng7m92	721	17	expression	expression	NN
cord-262445-54ng7m92	721	18	of	of	IN
cord-262445-54ng7m92	721	19	muscle	muscle	NN
cord-262445-54ng7m92	721	20	-	-	HYPH
cord-262445-54ng7m92	721	21	specific	specific	JJ
cord-262445-54ng7m92	721	22	genes	gene	NNS
cord-262445-54ng7m92	721	23	during	during	IN
cord-262445-54ng7m92	721	24	muscle	muscle	NN
cord-262445-54ng7m92	721	25	regeneration	regeneration	NN
cord-262445-54ng7m92	721	26	.	.	.
cord-262445-54ng7m92	722	1	The	the	DT
cord-262445-54ng7m92	722	2	transcription	transcription	NN
cord-262445-54ng7m92	722	3	factor	factor	NN
cord-262445-54ng7m92	722	4	NF	NF	NNP
cord-262445-54ng7m92	722	5	-	-	HYPH
cord-262445-54ng7m92	722	6	Y	Y	NNP
cord-262445-54ng7m92	722	7	,	,	,
cord-262445-54ng7m92	722	8	composed	compose	VBN
cord-262445-54ng7m92	722	9	by	by	IN
cord-262445-54ng7m92	722	10	NF	NF	NNP
cord-262445-54ng7m92	722	11	-	-	HYPH
cord-262445-54ng7m92	722	12	YA	YA	NNP
cord-262445-54ng7m92	722	13	,	,	,
cord-262445-54ng7m92	722	14	NF	NF	NNP
cord-262445-54ng7m92	722	15	-	-	HYPH
cord-262445-54ng7m92	722	16	YB	YB	NNP
cord-262445-54ng7m92	722	17	and	and	CC
cord-262445-54ng7m92	722	18	NF	NF	NNP
cord-262445-54ng7m92	722	19	-	-	HYPH
cord-262445-54ng7m92	722	20	YC	YC	NNP
cord-262445-54ng7m92	722	21	subunits	subunit	NNS
cord-262445-54ng7m92	722	22	,	,	,
cord-262445-54ng7m92	722	23	has	have	VBZ
cord-262445-54ng7m92	722	24	an	an	DT
cord-262445-54ng7m92	722	25	important	important	JJ
cord-262445-54ng7m92	722	26	role	role	NN
cord-262445-54ng7m92	722	27	in	in	IN
cord-262445-54ng7m92	722	28	the	the	DT
cord-262445-54ng7m92	722	29	regulation	regulation	NN
cord-262445-54ng7m92	722	30	of	of	IN
cord-262445-54ng7m92	722	31	cellular	cellular	JJ
cord-262445-54ng7m92	722	32	proliferation	proliferation	NN
cord-262445-54ng7m92	722	33	and	and	CC
cord-262445-54ng7m92	722	34	differentiation	differentiation	NN
cord-262445-54ng7m92	722	35	in	in	IN
cord-262445-54ng7m92	722	36	different	different	JJ
cord-262445-54ng7m92	722	37	cell	cell	NN
cord-262445-54ng7m92	722	38	types	type	NNS
cord-262445-54ng7m92	722	39	,	,	,
cord-262445-54ng7m92	722	40	among	among	IN
cord-262445-54ng7m92	722	41	which	which	WDT
cord-262445-54ng7m92	722	42	muscle	muscle	NN
cord-262445-54ng7m92	722	43	cells	cell	NNS
cord-262445-54ng7m92	722	44	.	.	.
cord-262445-54ng7m92	723	1	While	while	IN
cord-262445-54ng7m92	723	2	NF	NF	NNP
cord-262445-54ng7m92	723	3	-	-	HYPH
cord-262445-54ng7m92	723	4	YA	YA	NNP
cord-262445-54ng7m92	723	5	,	,	,
cord-262445-54ng7m92	723	6	the	the	DT
cord-262445-54ng7m92	723	7	DNA	dna	NN
cord-262445-54ng7m92	723	8	binding	binding	NN
cord-262445-54ng7m92	723	9	subunit	subunit	NN
cord-262445-54ng7m92	723	10	of	of	IN
cord-262445-54ng7m92	723	11	NF	NF	NNP
cord-262445-54ng7m92	723	12	-	-	HYPH
cord-262445-54ng7m92	723	13	Y	Y	NNP
cord-262445-54ng7m92	723	14	,	,	,
cord-262445-54ng7m92	723	15	is	be	VBZ
cord-262445-54ng7m92	723	16	down	down	RB
cord-262445-54ng7m92	723	17	-	-	HYPH
cord-262445-54ng7m92	723	18	regulated	regulate	VBN
cord-262445-54ng7m92	723	19	in	in	IN
cord-262445-54ng7m92	723	20	the	the	DT
cord-262445-54ng7m92	723	21	adult	adult	NN
cord-262445-54ng7m92	723	22	muscle	muscle	NN
cord-262445-54ng7m92	723	23	of	of	IN
cord-262445-54ng7m92	723	24	WT	WT	NNP
cord-262445-54ng7m92	723	25	mice	mouse	NNS
cord-262445-54ng7m92	723	26	,	,	,
cord-262445-54ng7m92	723	27	its	-PRON-	PRP$
cord-262445-54ng7m92	723	28	expression	expression	NN
cord-262445-54ng7m92	723	29	is	be	VBZ
cord-262445-54ng7m92	723	30	observed	observe	VBN
cord-262445-54ng7m92	723	31	in	in	IN
cord-262445-54ng7m92	723	32	the	the	DT
cord-262445-54ng7m92	723	33	mdx	mdx	NNP
cord-262445-54ng7m92	723	34	mouse	mouse	NN
cord-262445-54ng7m92	723	35	and	and	CC
cord-262445-54ng7m92	723	36	correlates	correlate	VBZ
cord-262445-54ng7m92	723	37	with	with	IN
cord-262445-54ng7m92	723	38	euchromatic	euchromatic	JJ
cord-262445-54ng7m92	723	39	markers	marker	NNS
cord-262445-54ng7m92	723	40	and	and	CC
cord-262445-54ng7m92	723	41	expression	expression	NN
cord-262445-54ng7m92	723	42	of	of	IN
cord-262445-54ng7m92	723	43	NF	NF	NNP
cord-262445-54ng7m92	723	44	-	-	HYPH
cord-262445-54ng7m92	723	45	Y	Y	NNP
cord-262445-54ng7m92	723	46	target	target	NN
cord-262445-54ng7m92	723	47	genes	gene	NNS
cord-262445-54ng7m92	723	48	controlling	control	VBG
cord-262445-54ng7m92	723	49	cell	cell	NN
cord-262445-54ng7m92	723	50	growth	growth	NN
cord-262445-54ng7m92	723	51	.	.	.
cord-262445-54ng7m92	724	1	With	with	IN
cord-262445-54ng7m92	724	2	the	the	DT
cord-262445-54ng7m92	724	3	aim	aim	NN
cord-262445-54ng7m92	724	4	to	to	TO
cord-262445-54ng7m92	724	5	investigate	investigate	VB
cord-262445-54ng7m92	724	6	the	the	DT
cord-262445-54ng7m92	724	7	role	role	NN
cord-262445-54ng7m92	724	8	of	of	IN
cord-262445-54ng7m92	724	9	NF	nf	NN
cord-262445-54ng7m92	724	10	-	-	HYPH
cord-262445-54ng7m92	724	11	YA	YA	NNP
cord-262445-54ng7m92	724	12	in	in	IN
cord-262445-54ng7m92	724	13	the	the	DT
cord-262445-54ng7m92	724	14	SCs	sc	NNS
cord-262445-54ng7m92	724	15	proliferation	proliferation	NN
cord-262445-54ng7m92	724	16	and	and	CC
cord-262445-54ng7m92	724	17	differentiation	differentiation	NN
cord-262445-54ng7m92	724	18	,	,	,
cord-262445-54ng7m92	724	19	we	-PRON-	PRP
cord-262445-54ng7m92	724	20	generated	generate	VBD
cord-262445-54ng7m92	724	21	and	and	CC
cord-262445-54ng7m92	724	22	characterized	characterize	VBD
cord-262445-54ng7m92	724	23	a	a	DT
cord-262445-54ng7m92	724	24	conditional	conditional	JJ
cord-262445-54ng7m92	724	25	knock	knock	NN
cord-262445-54ng7m92	724	26	out	out	RP
cord-262445-54ng7m92	724	27	mouse	mouse	NN
cord-262445-54ng7m92	724	28	model	model	NN
cord-262445-54ng7m92	724	29	in	in	IN
cord-262445-54ng7m92	724	30	which	which	WDT
cord-262445-54ng7m92	724	31	NF	NF	NNP
cord-262445-54ng7m92	724	32	-	-	HYPH
cord-262445-54ng7m92	724	33	YA	YA	NNP
cord-262445-54ng7m92	724	34	is	be	VBZ
cord-262445-54ng7m92	724	35	deleted	delete	VBN
cord-262445-54ng7m92	724	36	in	in	IN
cord-262445-54ng7m92	724	37	Pax7	Pax7	NNP
cord-262445-54ng7m92	724	38	+	+	CC
cord-262445-54ng7m92	724	39	SCs	sc	NNS
cord-262445-54ng7m92	724	40	by	by	IN
cord-262445-54ng7m92	724	41	Tamoxifen	Tamoxifen	NNP
cord-262445-54ng7m92	724	42	induction	induction	NN
cord-262445-54ng7m92	724	43	in	in	IN
cord-262445-54ng7m92	724	44	adult	adult	NN
cord-262445-54ng7m92	724	45	NF	nf	NN
cord-262445-54ng7m92	724	46	-	-	HYPH
cord-262445-54ng7m92	724	47	YA	YA	NNP
cord-262445-54ng7m92	724	48	flox	flox	NNP
cord-262445-54ng7m92	724	49	/	/	SYM
cord-262445-54ng7m92	724	50	flox	flox	NN
cord-262445-54ng7m92	724	51	:	:	:
cord-262445-54ng7m92	725	1	Pax7	Pax7	NNP
cord-262445-54ng7m92	725	2	CreER	CreER	NNP
cord-262445-54ng7m92	725	3	mice	mouse	NNS
cord-262445-54ng7m92	725	4	(	(	-LRB-
cord-262445-54ng7m92	725	5	NF	NF	NNP
cord-262445-54ng7m92	725	6	-	-	HYPH
cord-262445-54ng7m92	725	7	YA	YA	NNP
cord-262445-54ng7m92	725	8	cKO	cKO	NNP
cord-262445-54ng7m92	725	9	)	)	-RRB-
cord-262445-54ng7m92	725	10	.	.	.
cord-262445-54ng7m92	726	1	Cellular	cellular	JJ
cord-262445-54ng7m92	726	2	and	and	CC
cord-262445-54ng7m92	726	3	molecular	molecular	JJ
cord-262445-54ng7m92	726	4	analysis	analysis	NN
cord-262445-54ng7m92	726	5	carried	carry	VBD
cord-262445-54ng7m92	726	6	out	out	RP
cord-262445-54ng7m92	726	7	on	on	IN
cord-262445-54ng7m92	726	8	isolated	isolate	VBN
cord-262445-54ng7m92	726	9	myofibers	myofiber	NNS
cord-262445-54ng7m92	726	10	and	and	CC
cord-262445-54ng7m92	726	11	SCs	sc	NNS
cord-262445-54ng7m92	726	12	from	from	IN
cord-262445-54ng7m92	726	13	WT	WT	NNP
cord-262445-54ng7m92	726	14	and	and	CC
cord-262445-54ng7m92	726	15	NF	NF	NNP
cord-262445-54ng7m92	726	16	-	-	HYPH
cord-262445-54ng7m92	726	17	YA	YA	NNP
cord-262445-54ng7m92	726	18	cKO	cKO	NNP
cord-262445-54ng7m92	726	19	mice	mouse	NNS
cord-262445-54ng7m92	726	20	highlighted	highlight	VBD
cord-262445-54ng7m92	726	21	that	that	IN
cord-262445-54ng7m92	726	22	NF	NF	NNP
cord-262445-54ng7m92	726	23	-	-	HYPH
cord-262445-54ng7m92	726	24	Y	Y	NNP
cord-262445-54ng7m92	726	25	activity	activity	NN
cord-262445-54ng7m92	726	26	is	be	VBZ
cord-262445-54ng7m92	726	27	important	important	JJ
cord-262445-54ng7m92	726	28	for	for	IN
cord-262445-54ng7m92	726	29	the	the	DT
cord-262445-54ng7m92	726	30	maintenance	maintenance	NN
cord-262445-54ng7m92	726	31	of	of	IN
cord-262445-54ng7m92	726	32	SCs	sc	NNS
cord-262445-54ng7m92	726	33	homeostasis	homeostasis	NN
cord-262445-54ng7m92	726	34	.	.	.
cord-262445-54ng7m92	727	1	NF	NF	NNP
cord-262445-54ng7m92	727	2	-	-	HYPH
cord-262445-54ng7m92	727	3	YA	YA	NNP
cord-262445-54ng7m92	727	4	loss	loss	NN
cord-262445-54ng7m92	727	5	depletes	deplete	VBZ
cord-262445-54ng7m92	727	6	Pax7	Pax7	NNP
cord-262445-54ng7m92	727	7	+	+	CC
cord-262445-54ng7m92	727	8	SCs	scs	NN
cord-262445-54ng7m92	727	9	pool	pool	NN
cord-262445-54ng7m92	727	10	and	and	CC
cord-262445-54ng7m92	727	11	impairs	impair	VBZ
cord-262445-54ng7m92	727	12	their	-PRON-	PRP$
cord-262445-54ng7m92	727	13	proliferation	proliferation	NN
cord-262445-54ng7m92	727	14	.	.	.
cord-262445-54ng7m92	728	1	Moreover	moreover	RB
cord-262445-54ng7m92	728	2	,	,	,
cord-262445-54ng7m92	728	3	SCs	sc	NNS
cord-262445-54ng7m92	728	4	-	-	HYPH
cord-262445-54ng7m92	728	5	mediated	mediate	VBN
cord-262445-54ng7m92	728	6	regeneration	regeneration	NN
cord-262445-54ng7m92	728	7	following	follow	VBG
cord-262445-54ng7m92	728	8	muscle	muscle	NN
cord-262445-54ng7m92	728	9	damage	damage	NN
cord-262445-54ng7m92	728	10	induced	induce	VBN
cord-262445-54ng7m92	728	11	by	by	IN
cord-262445-54ng7m92	728	12	cardiotoxin	cardiotoxin	NNP
cord-262445-54ng7m92	728	13	is	be	VBZ
cord-262445-54ng7m92	728	14	delayed	delay	VBN
cord-262445-54ng7m92	728	15	in	in	IN
cord-262445-54ng7m92	728	16	NF	NF	NNP
cord-262445-54ng7m92	728	17	-	-	HYPH
cord-262445-54ng7m92	728	18	YA	YA	NNP
cord-262445-54ng7m92	728	19	cKO	cKO	NNP
cord-262445-54ng7m92	728	20	.	.	.
cord-262445-54ng7m92	729	1	The	the	DT
cord-262445-54ng7m92	729	2	effect	effect	NN
cord-262445-54ng7m92	729	3	of	of	IN
cord-262445-54ng7m92	729	4	NF	nf	NN
cord-262445-54ng7m92	729	5	-	-	HYPH
cord-262445-54ng7m92	729	6	YA	YA	NNP
cord-262445-54ng7m92	729	7	abrogation	abrogation	NN
cord-262445-54ng7m92	729	8	was	be	VBD
cord-262445-54ng7m92	729	9	also	also	RB
cord-262445-54ng7m92	729	10	explored	explore	VBN
cord-262445-54ng7m92	729	11	in	in	IN
cord-262445-54ng7m92	729	12	post	post	JJ
cord-262445-54ng7m92	729	13	-	-	JJ
cord-262445-54ng7m92	729	14	natal	natal	JJ
cord-262445-54ng7m92	729	15	muscle	muscle	NN
cord-262445-54ng7m92	729	16	growth	growth	NN
cord-262445-54ng7m92	729	17	.	.	.
cord-262445-54ng7m92	730	1	Immunohistological	Immunohistological	NNP
cord-262445-54ng7m92	730	2	analysis	analysis	NN
cord-262445-54ng7m92	730	3	showed	show	VBD
cord-262445-54ng7m92	730	4	defects	defect	NNS
cord-262445-54ng7m92	730	5	in	in	IN
cord-262445-54ng7m92	730	6	muscle	muscle	NN
cord-262445-54ng7m92	730	7	morphology	morphology	NN
cord-262445-54ng7m92	730	8	and	and	CC
cord-262445-54ng7m92	730	9	a	a	DT
cord-262445-54ng7m92	730	10	decrease	decrease	NN
cord-262445-54ng7m92	730	11	in	in	IN
cord-262445-54ng7m92	730	12	SCs	SCs	NNP
cord-262445-54ng7m92	730	13	number	number	NN
cord-262445-54ng7m92	730	14	in	in	IN
cord-262445-54ng7m92	730	15	3	3	CD
cord-262445-54ng7m92	730	16	weeks	week	NNS
cord-262445-54ng7m92	730	17	aged	aged	JJ
cord-262445-54ng7m92	730	18	NF	nf	NN
cord-262445-54ng7m92	730	19	-	-	HYPH
cord-262445-54ng7m92	730	20	YA	YA	NNP
cord-262445-54ng7m92	730	21	cKO	cKO	NNP
cord-262445-54ng7m92	730	22	mice	mouse	NNS
cord-262445-54ng7m92	730	23	,	,	,
cord-262445-54ng7m92	730	24	period	period	NN
cord-262445-54ng7m92	730	25	of	of	IN
cord-262445-54ng7m92	730	26	major	major	JJ
cord-262445-54ng7m92	730	27	increment	increment	NN
cord-262445-54ng7m92	730	28	of	of	IN
cord-262445-54ng7m92	730	29	muscle	muscle	NN
cord-262445-54ng7m92	730	30	mass	mass	NN
cord-262445-54ng7m92	730	31	by	by	IN
cord-262445-54ng7m92	730	32	SCs	scs	NN
cord-262445-54ng7m92	730	33	-	-	HYPH
cord-262445-54ng7m92	730	34	mediated	mediate	VBN
cord-262445-54ng7m92	730	35	myonuclear	myonuclear	NN
cord-262445-54ng7m92	730	36	accretion	accretion	NN
cord-262445-54ng7m92	730	37	.	.	.
cord-262445-54ng7m92	731	1	The	the	DT
cord-262445-54ng7m92	731	2	molecular	molecular	JJ
cord-262445-54ng7m92	731	3	mechanism	mechanism	NN
cord-262445-54ng7m92	731	4	underlying	underlie	VBG
cord-262445-54ng7m92	731	5	the	the	DT
cord-262445-54ng7m92	731	6	impairment	impairment	NN
cord-262445-54ng7m92	731	7	of	of	IN
cord-262445-54ng7m92	731	8	SCs	sc	NNS
cord-262445-54ng7m92	731	9	activity	activity	NN
cord-262445-54ng7m92	731	10	following	follow	VBG
cord-262445-54ng7m92	731	11	NF	nf	NN
cord-262445-54ng7m92	731	12	-	-	HYPH
cord-262445-54ng7m92	731	13	YA	YA	NNP
cord-262445-54ng7m92	731	14	loss	loss	NN
cord-262445-54ng7m92	731	15	was	be	VBD
cord-262445-54ng7m92	731	16	investigated	investigate	VBN
cord-262445-54ng7m92	731	17	by	by	IN
cord-262445-54ng7m92	731	18	gene	gene	NN
cord-262445-54ng7m92	731	19	expression	expression	NN
cord-262445-54ng7m92	731	20	profiling	profiling	NN
cord-262445-54ng7m92	731	21	.	.	.
cord-262445-54ng7m92	732	1	Overall	overall	RB
cord-262445-54ng7m92	732	2	,	,	,
cord-262445-54ng7m92	732	3	our	-PRON-	PRP$
cord-262445-54ng7m92	732	4	results	result	NNS
cord-262445-54ng7m92	732	5	highlight	highlight	VBP
cord-262445-54ng7m92	732	6	a	a	DT
cord-262445-54ng7m92	732	7	role	role	NN
cord-262445-54ng7m92	732	8	of	of	IN
cord-262445-54ng7m92	732	9	NF	NF	NNP
cord-262445-54ng7m92	732	10	-	-	HYPH
cord-262445-54ng7m92	732	11	Y	Y	NNP
cord-262445-54ng7m92	732	12	in	in	IN
cord-262445-54ng7m92	732	13	muscle	muscle	NN
cord-262445-54ng7m92	732	14	regeneration	regeneration	NN
cord-262445-54ng7m92	732	15	and	and	CC
cord-262445-54ng7m92	732	16	in	in	IN
cord-262445-54ng7m92	732	17	SCs	SCs	NNP
cord-262445-54ng7m92	732	18	fate	fate	NNP
cord-262445-54ng7m92	732	19	,	,	,
cord-262445-54ng7m92	732	20	whose	whose	WP$
cord-262445-54ng7m92	732	21	modulation	modulation	NN
cord-262445-54ng7m92	732	22	could	could	MD
cord-262445-54ng7m92	732	23	be	be	VB
cord-262445-54ng7m92	732	24	useful	useful	JJ
cord-262445-54ng7m92	732	25	to	to	TO
cord-262445-54ng7m92	732	26	improve	improve	VB
cord-262445-54ng7m92	732	27	stem	stem	NN
cord-262445-54ng7m92	732	28	cell	cell	NN
cord-262445-54ng7m92	732	29	based	base	VBN
cord-262445-54ng7m92	732	30	therapies	therapy	NNS
cord-262445-54ng7m92	732	31	to	to	TO
cord-262445-54ng7m92	732	32	treat	treat	VB
cord-262445-54ng7m92	732	33	muscular	muscular	JJ
cord-262445-54ng7m92	732	34	dystrophies	dystrophy	NNS
cord-262445-54ng7m92	732	35	.	.	.
cord-262445-54ng7m92	733	1	Thyroid	thyroid	JJ
cord-262445-54ng7m92	733	2	hormone	hormone	NN
cord-262445-54ng7m92	733	3	(	(	-LRB-
cord-262445-54ng7m92	733	4	TH	TH	NNP
cord-262445-54ng7m92	733	5	)	)	-RRB-
cord-262445-54ng7m92	733	6	is	be	VBZ
cord-262445-54ng7m92	733	7	a	a	DT
cord-262445-54ng7m92	733	8	key	key	JJ
cord-262445-54ng7m92	733	9	metabolic	metabolic	JJ
cord-262445-54ng7m92	733	10	regulator	regulator	NN
cord-262445-54ng7m92	733	11	that	that	WDT
cord-262445-54ng7m92	733	12	acts	act	VBZ
cord-262445-54ng7m92	733	13	by	by	IN
cord-262445-54ng7m92	733	14	coordinating	coordinate	VBG
cord-262445-54ng7m92	733	15	short	short	JJ
cord-262445-54ng7m92	733	16	-	-	HYPH
cord-262445-54ng7m92	733	17	term	term	NN
cord-262445-54ng7m92	733	18	and	and	CC
cord-262445-54ng7m92	733	19	long	long	JJ
cord-262445-54ng7m92	733	20	-	-	HYPH
cord-262445-54ng7m92	733	21	term	term	NN
cord-262445-54ng7m92	733	22	energy	energy	NN
cord-262445-54ng7m92	733	23	needs	need	NNS
cord-262445-54ng7m92	733	24	.	.	.
cord-262445-54ng7m92	734	1	Accordingly	accordingly	RB
cord-262445-54ng7m92	734	2	,	,	,
cord-262445-54ng7m92	734	3	significant	significant	JJ
cord-262445-54ng7m92	734	4	metabolic	metabolic	JJ
cord-262445-54ng7m92	734	5	changes	change	NNS
cord-262445-54ng7m92	734	6	are	be	VBP
cord-262445-54ng7m92	734	7	depending	depend	VBG
cord-262445-54ng7m92	734	8	on	on	IN
cord-262445-54ng7m92	734	9	thyroid	thyroid	NN
cord-262445-54ng7m92	734	10	status	status	NN
cord-262445-54ng7m92	734	11	.	.	.
cord-262445-54ng7m92	735	1	Although	although	IN
cord-262445-54ng7m92	735	2	it	-PRON-	PRP
cord-262445-54ng7m92	735	3	is	be	VBZ
cord-262445-54ng7m92	735	4	established	establish	VBN
cord-262445-54ng7m92	735	5	that	that	IN
cord-262445-54ng7m92	735	6	hyperthyroidism	hyperthyroidism	NN
cord-262445-54ng7m92	735	7	augments	augment	VBZ
cord-262445-54ng7m92	735	8	basal	basal	JJ
cord-262445-54ng7m92	735	9	energy	energy	NN
cord-262445-54ng7m92	735	10	consumption	consumption	NN
cord-262445-54ng7m92	735	11	,	,	,
cord-262445-54ng7m92	735	12	thus	thus	RB
cord-262445-54ng7m92	735	13	resulting	result	VBG
cord-262445-54ng7m92	735	14	in	in	IN
cord-262445-54ng7m92	735	15	enhanced	enhanced	JJ
cord-262445-54ng7m92	735	16	metabolic	metabolic	JJ
cord-262445-54ng7m92	735	17	state	state	NN
cord-262445-54ng7m92	735	18	,	,	,
cord-262445-54ng7m92	735	19	the	the	DT
cord-262445-54ng7m92	735	20	net	net	JJ
cord-262445-54ng7m92	735	21	effects	effect	NNS
cord-262445-54ng7m92	735	22	on	on	IN
cord-262445-54ng7m92	735	23	cellular	cellular	JJ
cord-262445-54ng7m92	735	24	respiration	respiration	NN
cord-262445-54ng7m92	735	25	and	and	CC
cord-262445-54ng7m92	735	26	generation	generation	NN
cord-262445-54ng7m92	735	27	of	of	IN
cord-262445-54ng7m92	735	28	reactive	reactive	JJ
cord-262445-54ng7m92	735	29	oxygen	oxygen	NN
cord-262445-54ng7m92	735	30	species	specie	NNS
cord-262445-54ng7m92	735	31	(	(	-LRB-
cord-262445-54ng7m92	735	32	ROS	ROS	NNP
cord-262445-54ng7m92	735	33	)	)	-RRB-
cord-262445-54ng7m92	735	34	remain	remain	VBP
cord-262445-54ng7m92	735	35	unclear	unclear	JJ
cord-262445-54ng7m92	735	36	.	.	.
cord-262445-54ng7m92	736	1	To	to	TO
cord-262445-54ng7m92	736	2	elucidate	elucidate	VB
cord-262445-54ng7m92	736	3	the	the	DT
cord-262445-54ng7m92	736	4	effects	effect	NNS
cord-262445-54ng7m92	736	5	of	of	IN
cord-262445-54ng7m92	736	6	augmented	augment	VBN
cord-262445-54ng7m92	736	7	TH	TH	NNP
cord-262445-54ng7m92	736	8	signal	signal	NN
cord-262445-54ng7m92	736	9	in	in	IN
cord-262445-54ng7m92	736	10	muscle	muscle	NN
cord-262445-54ng7m92	736	11	cells	cell	NNS
cord-262445-54ng7m92	736	12	,	,	,
cord-262445-54ng7m92	736	13	we	-PRON-	PRP
cord-262445-54ng7m92	736	14	generated	generate	VBD
cord-262445-54ng7m92	736	15	a	a	DT
cord-262445-54ng7m92	736	16	doxycycline	doxycycline	NN
cord-262445-54ng7m92	736	17	-	-	HYPH
cord-262445-54ng7m92	736	18	inducible	inducible	JJ
cord-262445-54ng7m92	736	19	cell	cell	NN
cord-262445-54ng7m92	736	20	line	line	NN
cord-262445-54ng7m92	736	21	,	,	,
cord-262445-54ng7m92	736	22	in	in	IN
cord-262445-54ng7m92	736	23	which	which	WDT
cord-262445-54ng7m92	736	24	the	the	DT
cord-262445-54ng7m92	736	25	expression	expression	NN
cord-262445-54ng7m92	736	26	of	of	IN
cord-262445-54ng7m92	736	27	the	the	DT
cord-262445-54ng7m92	736	28	TH	TH	NNP
cord-262445-54ng7m92	736	29	-	-	HYPH
cord-262445-54ng7m92	736	30	activating	activate	VBG
cord-262445-54ng7m92	736	31	enzyme	enzyme	NN
cord-262445-54ng7m92	736	32	,	,	,
cord-262445-54ng7m92	736	33	type	type	NN
cord-262445-54ng7m92	736	34	II	II	NNP
cord-262445-54ng7m92	736	35	deiodinase	deiodinase	NN
cord-262445-54ng7m92	736	36	(	(	-LRB-
cord-262445-54ng7m92	736	37	D2	D2	NNP
cord-262445-54ng7m92	736	38	)	)	-RRB-
cord-262445-54ng7m92	736	39	is	be	VBZ
cord-262445-54ng7m92	736	40	reversibly	reversibly	RB
cord-262445-54ng7m92	736	41	turned	turn	VBN
cord-262445-54ng7m92	736	42	on	on	RP
cord-262445-54ng7m92	736	43	by	by	IN
cord-262445-54ng7m92	736	44	the	the	DT
cord-262445-54ng7m92	736	45	"	"	``
cord-262445-54ng7m92	736	46	Tet	Tet	NNP
cord-262445-54ng7m92	736	47	-	-	HYPH
cord-262445-54ng7m92	736	48	ON	on	NN
cord-262445-54ng7m92	736	49	"	"	''
cord-262445-54ng7m92	736	50	system	system	NN
cord-262445-54ng7m92	736	51	.	.	.
cord-262445-54ng7m92	737	1	Interestingly	interestingly	RB
cord-262445-54ng7m92	737	2	,	,	,
cord-262445-54ng7m92	737	3	increased	increase	VBN
cord-262445-54ng7m92	737	4	intracellular	intracellular	JJ
cord-262445-54ng7m92	737	5	TH	TH	NNP
cord-262445-54ng7m92	737	6	caused	cause	VBD
cord-262445-54ng7m92	737	7	a	a	DT
cord-262445-54ng7m92	737	8	net	net	JJ
cord-262445-54ng7m92	737	9	shift	shift	NN
cord-262445-54ng7m92	737	10	from	from	IN
cord-262445-54ng7m92	737	11	Oxidative	oxidative	JJ
cord-262445-54ng7m92	737	12	Phosphorylation	Phosphorylation	NNP
cord-262445-54ng7m92	737	13	(	(	-LRB-
cord-262445-54ng7m92	737	14	OXPHOS	OXPHOS	NNP
cord-262445-54ng7m92	737	15	)	)	-RRB-
cord-262445-54ng7m92	737	16	to	to	IN
cord-262445-54ng7m92	737	17	glycolysis	glycolysis	NN
cord-262445-54ng7m92	737	18	and	and	CC
cord-262445-54ng7m92	737	19	a	a	DT
cord-262445-54ng7m92	737	20	consequent	consequent	JJ
cord-262445-54ng7m92	737	21	increase	increase	NN
cord-262445-54ng7m92	737	22	in	in	IN
cord-262445-54ng7m92	737	23	extracellular	extracellular	JJ
cord-262445-54ng7m92	737	24	acidification	acidification	NN
cord-262445-54ng7m92	737	25	rate	rate	NN
cord-262445-54ng7m92	737	26	.	.	.
cord-262445-54ng7m92	738	1	As	as	IN
cord-262445-54ng7m92	738	2	a	a	DT
cord-262445-54ng7m92	738	3	result	result	NN
cord-262445-54ng7m92	738	4	,	,	,
cord-262445-54ng7m92	738	5	the	the	DT
cord-262445-54ng7m92	738	6	mitochondrial	mitochondrial	JJ
cord-262445-54ng7m92	738	7	ROS	ROS	NNP
cord-262445-54ng7m92	738	8	production	production	NN
cord-262445-54ng7m92	738	9	,	,	,
cord-262445-54ng7m92	738	10	and	and	CC
cord-262445-54ng7m92	738	11	both	both	CC
cord-262445-54ng7m92	738	12	the	the	DT
cord-262445-54ng7m92	738	13	basal	basal	NN
cord-262445-54ng7m92	738	14	and	and	CC
cord-262445-54ng7m92	738	15	doxorubicin	doxorubicin	NN
cord-262445-54ng7m92	738	16	-	-	HYPH
cord-262445-54ng7m92	738	17	induced	induce	VBN
cord-262445-54ng7m92	738	18	production	production	NN
cord-262445-54ng7m92	738	19	of	of	IN
cord-262445-54ng7m92	738	20	cellular	cellular	JJ
cord-262445-54ng7m92	738	21	ROS	ROS	NNP
cord-262445-54ng7m92	738	22	were	be	VBD
cord-262445-54ng7m92	738	23	reduced	reduce	VBN
cord-262445-54ng7m92	738	24	.	.	.
cord-262445-54ng7m92	739	1	Importantly	importantly	RB
cord-262445-54ng7m92	739	2	,	,	,
cord-262445-54ng7m92	739	3	the	the	DT
cord-262445-54ng7m92	739	4	expression	expression	NN
cord-262445-54ng7m92	739	5	of	of	IN
cord-262445-54ng7m92	739	6	a	a	DT
cord-262445-54ng7m92	739	7	set	set	NN
cord-262445-54ng7m92	739	8	of	of	IN
cord-262445-54ng7m92	739	9	antioxidant	antioxidant	JJ
cord-262445-54ng7m92	739	10	genes	gene	NNS
cord-262445-54ng7m92	739	11	was	be	VBD
cord-262445-54ng7m92	739	12	up	up	RB
cord-262445-54ng7m92	739	13	-	-	HYPH
cord-262445-54ng7m92	739	14	regulated	regulate	VBN
cord-262445-54ng7m92	739	15	,	,	,
cord-262445-54ng7m92	739	16	and	and	CC
cord-262445-54ng7m92	739	17	,	,	,
cord-262445-54ng7m92	739	18	among	among	IN
cord-262445-54ng7m92	739	19	them	-PRON-	PRP
cord-262445-54ng7m92	739	20	,	,	,
cord-262445-54ng7m92	739	21	the	the	DT
cord-262445-54ng7m92	739	22	mitochondrial	mitochondrial	JJ
cord-262445-54ng7m92	739	23	scavenger	scavenger	NN
cord-262445-54ng7m92	739	24	SOD2	SOD2	NNP
cord-262445-54ng7m92	739	25	was	be	VBD
cord-262445-54ng7m92	739	26	specifically	specifically	RB
cord-262445-54ng7m92	739	27	induced	induce	VBN
cord-262445-54ng7m92	739	28	at	at	IN
cord-262445-54ng7m92	739	29	transcriptional	transcriptional	JJ
cord-262445-54ng7m92	739	30	level	level	NN
cord-262445-54ng7m92	739	31	,	,	,
cord-262445-54ng7m92	739	32	by	by	IN
cord-262445-54ng7m92	739	33	D2-mediated	d2-mediate	VBN
cord-262445-54ng7m92	739	34	TH	TH	NNP
cord-262445-54ng7m92	739	35	activation	activation	NN
cord-262445-54ng7m92	739	36	.	.	.
cord-262445-54ng7m92	740	1	Finally	finally	RB
cord-262445-54ng7m92	740	2	,	,	,
cord-262445-54ng7m92	740	3	we	-PRON-	PRP
cord-262445-54ng7m92	740	4	observed	observe	VBD
cord-262445-54ng7m92	740	5	that	that	IN
cord-262445-54ng7m92	740	6	the	the	DT
cord-262445-54ng7m92	740	7	attenuation	attenuation	NN
cord-262445-54ng7m92	740	8	of	of	IN
cord-262445-54ng7m92	740	9	the	the	DT
cord-262445-54ng7m92	740	10	oxidative	oxidative	JJ
cord-262445-54ng7m92	740	11	stress	stress	NN
cord-262445-54ng7m92	740	12	and	and	CC
cord-262445-54ng7m92	740	13	increased	increase	VBN
cord-262445-54ng7m92	740	14	levels	level	NNS
cord-262445-54ng7m92	740	15	of	of	IN
cord-262445-54ng7m92	740	16	SOD2	SOD2	NNP
cord-262445-54ng7m92	740	17	are	be	VBP
cord-262445-54ng7m92	740	18	key	key	JJ
cord-262445-54ng7m92	740	19	elements	element	NNS
cord-262445-54ng7m92	740	20	of	of	IN
cord-262445-54ng7m92	740	21	the	the	DT
cord-262445-54ng7m92	740	22	differentiating	differentiate	VBG
cord-262445-54ng7m92	740	23	cascade	cascade	NN
cord-262445-54ng7m92	740	24	triggered	trigger	VBN
cord-262445-54ng7m92	740	25	by	by	IN
cord-262445-54ng7m92	740	26	the	the	DT
cord-262445-54ng7m92	740	27	TH	TH	NNP
cord-262445-54ng7m92	740	28	and	and	CC
cord-262445-54ng7m92	740	29	D2	D2	NNP
cord-262445-54ng7m92	740	30	,	,	,
cord-262445-54ng7m92	740	31	thereby	thereby	RB
cord-262445-54ng7m92	740	32	establishing	establish	VBG
cord-262445-54ng7m92	740	33	that	that	IN
cord-262445-54ng7m92	740	34	D2	d2	NN
cord-262445-54ng7m92	740	35	is	be	VBZ
cord-262445-54ng7m92	740	36	essential	essential	JJ
cord-262445-54ng7m92	740	37	in	in	IN
cord-262445-54ng7m92	740	38	coordinating	coordinate	VBG
cord-262445-54ng7m92	740	39	metabolic	metabolic	JJ
cord-262445-54ng7m92	740	40	reprogramming	reprogramming	NN
cord-262445-54ng7m92	740	41	of	of	IN
cord-262445-54ng7m92	740	42	myocytes	myocyte	NNS
cord-262445-54ng7m92	740	43	during	during	IN
cord-262445-54ng7m92	740	44	myogenic	myogenic	JJ
cord-262445-54ng7m92	740	45	differentiation	differentiation	NN
cord-262445-54ng7m92	740	46	.	.	.
cord-262445-54ng7m92	741	1	In	in	IN
cord-262445-54ng7m92	741	2	conclusion	conclusion	NN
cord-262445-54ng7m92	741	3	,	,	,
cord-262445-54ng7m92	741	4	our	-PRON-	PRP$
cord-262445-54ng7m92	741	5	findings	finding	NNS
cord-262445-54ng7m92	741	6	indicate	indicate	VBP
cord-262445-54ng7m92	741	7	that	that	IN
cord-262445-54ng7m92	741	8	TH	TH	NNP
cord-262445-54ng7m92	741	9	plays	play	VBZ
cord-262445-54ng7m92	741	10	a	a	DT
cord-262445-54ng7m92	741	11	key	key	JJ
cord-262445-54ng7m92	741	12	role	role	NN
cord-262445-54ng7m92	741	13	in	in	IN
cord-262445-54ng7m92	741	14	oxidative	oxidative	JJ
cord-262445-54ng7m92	741	15	stress	stress	NN
cord-262445-54ng7m92	741	16	dynamics	dynamic	NNS
cord-262445-54ng7m92	741	17	by	by	IN
cord-262445-54ng7m92	741	18	regulating	regulate	VBG
cord-262445-54ng7m92	741	19	ROS	ROS	NNP
cord-262445-54ng7m92	741	20	generation	generation	NN
cord-262445-54ng7m92	741	21	.	.	.
cord-262445-54ng7m92	742	1	Our	-PRON-	PRP$
cord-262445-54ng7m92	742	2	novel	novel	NN
cord-262445-54ng7m92	742	3	finding	finding	NN
cord-262445-54ng7m92	742	4	that	that	IN
cord-262445-54ng7m92	742	5	TH	TH	NNP
cord-262445-54ng7m92	742	6	and	and	CC
cord-262445-54ng7m92	742	7	its	-PRON-	PRP$
cord-262445-54ng7m92	742	8	intracellular	intracellular	JJ
cord-262445-54ng7m92	742	9	metabolism	metabolism	NN
cord-262445-54ng7m92	742	10	act	act	NN
cord-262445-54ng7m92	742	11	as	as	IN
cord-262445-54ng7m92	742	12	mitochondrial	mitochondrial	JJ
cord-262445-54ng7m92	742	13	detoxifying	detoxify	VBG
cord-262445-54ng7m92	742	14	agents	agent	NNS
cord-262445-54ng7m92	742	15	sheds	shed	VBZ
cord-262445-54ng7m92	742	16	new	new	JJ
cord-262445-54ng7m92	742	17	light	light	NN
cord-262445-54ng7m92	742	18	on	on	IN
cord-262445-54ng7m92	742	19	metabolic	metabolic	JJ
cord-262445-54ng7m92	742	20	processes	process	NNS
cord-262445-54ng7m92	742	21	relevant	relevant	JJ
cord-262445-54ng7m92	742	22	to	to	IN
cord-262445-54ng7m92	742	23	muscle	muscle	NN
cord-262445-54ng7m92	742	24	physiology	physiology	NN
cord-262445-54ng7m92	743	1	The	the	DT
cord-262445-54ng7m92	743	2	functional	functional	JJ
cord-262445-54ng7m92	743	3	exhaustion	exhaustion	NN
cord-262445-54ng7m92	743	4	of	of	IN
cord-262445-54ng7m92	743	5	muscle	muscle	NN
cord-262445-54ng7m92	743	6	stem	stem	NN
cord-262445-54ng7m92	743	7	cells	cell	NNS
cord-262445-54ng7m92	743	8	(	(	-LRB-
cord-262445-54ng7m92	743	9	MuSCs	MuSCs	NNP
cord-262445-54ng7m92	743	10	)	)	-RRB-
cord-262445-54ng7m92	743	11	contributes	contribute	VBZ
cord-262445-54ng7m92	743	12	to	to	IN
cord-262445-54ng7m92	743	13	Duchenne	Duchenne	NNP
cord-262445-54ng7m92	743	14	Muscular	muscular	JJ
cord-262445-54ng7m92	743	15	Dystrophy	Dystrophy	NNP
cord-262445-54ng7m92	743	16	(	(	-LRB-
cord-262445-54ng7m92	743	17	DMD	DMD	NNP
cord-262445-54ng7m92	743	18	)	)	-RRB-
cord-262445-54ng7m92	743	19	progression	progression	NN
cord-262445-54ng7m92	743	20	by	by	IN
cord-262445-54ng7m92	743	21	compromising	compromise	VBG
cord-262445-54ng7m92	743	22	the	the	DT
cord-262445-54ng7m92	743	23	compensatory	compensatory	JJ
cord-262445-54ng7m92	743	24	regeneration	regeneration	NN
cord-262445-54ng7m92	743	25	of	of	IN
cord-262445-54ng7m92	743	26	diseased	diseased	JJ
cord-262445-54ng7m92	743	27	muscles	muscle	NNS
cord-262445-54ng7m92	743	28	.	.	.
cord-262445-54ng7m92	744	1	MuSCs	MuSCs	NNP
cord-262445-54ng7m92	744	2	activity	activity	NN
cord-262445-54ng7m92	744	3	is	be	VBZ
cord-262445-54ng7m92	744	4	influenced	influence	VBN
cord-262445-54ng7m92	744	5	by	by	IN
cord-262445-54ng7m92	744	6	functional	functional	JJ
cord-262445-54ng7m92	744	7	interactions	interaction	NNS
cord-262445-54ng7m92	744	8	with	with	IN
cord-262445-54ng7m92	744	9	cell	cell	NN
cord-262445-54ng7m92	744	10	types	type	NNS
cord-262445-54ng7m92	744	11	that	that	WDT
cord-262445-54ng7m92	744	12	compose	compose	VBP
cord-262445-54ng7m92	744	13	their	-PRON-	PRP$
cord-262445-54ng7m92	744	14	niche	niche	NN
cord-262445-54ng7m92	744	15	,	,	,
cord-262445-54ng7m92	744	16	including	include	VBG
cord-262445-54ng7m92	744	17	fibro	fibro	NN
cord-262445-54ng7m92	744	18	-	-	HYPH
cord-262445-54ng7m92	744	19	adipogenic	adipogenic	JJ
cord-262445-54ng7m92	744	20	progenitors	progenitor	NNS
cord-262445-54ng7m92	744	21	(	(	-LRB-
cord-262445-54ng7m92	744	22	FAPs	FAPs	NNP
cord-262445-54ng7m92	744	23	)	)	-RRB-
cord-262445-54ng7m92	744	24	that	that	WDT
cord-262445-54ng7m92	744	25	regulate	regulate	VBP
cord-262445-54ng7m92	744	26	the	the	DT
cord-262445-54ng7m92	744	27	regenerative	regenerative	JJ
cord-262445-54ng7m92	744	28	ability	ability	NN
cord-262445-54ng7m92	744	29	of	of	IN
cord-262445-54ng7m92	744	30	skeletal	skeletal	JJ
cord-262445-54ng7m92	744	31	muscles	muscle	NNS
cord-262445-54ng7m92	744	32	in	in	IN
cord-262445-54ng7m92	744	33	physiological	physiological	JJ
cord-262445-54ng7m92	744	34	and	and	CC
cord-262445-54ng7m92	744	35	pathological	pathological	JJ
cord-262445-54ng7m92	744	36	conditions	condition	NNS
cord-262445-54ng7m92	744	37	.	.	.
cord-262445-54ng7m92	745	1	We	-PRON-	PRP
cord-262445-54ng7m92	745	2	have	have	VBP
cord-262445-54ng7m92	745	3	recently	recently	RB
cord-262445-54ng7m92	745	4	discovered	discover	VBN
cord-262445-54ng7m92	745	5	that	that	IN
cord-262445-54ng7m92	745	6	FAP	fap	NN
cord-262445-54ng7m92	745	7	-	-	HYPH
cord-262445-54ng7m92	745	8	derived	derive	VBN
cord-262445-54ng7m92	745	9	Extracellular	Extracellular	NNP
cord-262445-54ng7m92	745	10	Vesicles	Vesicles	NNP
cord-262445-54ng7m92	745	11	(	(	-LRB-
cord-262445-54ng7m92	745	12	EVs	ev	NNS
cord-262445-54ng7m92	745	13	)	)	-RRB-
cord-262445-54ng7m92	745	14	support	support	VBP
cord-262445-54ng7m92	745	15	functional	functional	JJ
cord-262445-54ng7m92	745	16	interactions	interaction	NNS
cord-262445-54ng7m92	745	17	with	with	IN
cord-262445-54ng7m92	745	18	MuSCs	MuSCs	NNP
cord-262445-54ng7m92	745	19	,	,	,
cord-262445-54ng7m92	745	20	and	and	CC
cord-262445-54ng7m92	745	21	contribute	contribute	VB
cord-262445-54ng7m92	745	22	to	to	IN
cord-262445-54ng7m92	745	23	the	the	DT
cord-262445-54ng7m92	745	24	beneficial	beneficial	JJ
cord-262445-54ng7m92	745	25	effect	effect	NN
cord-262445-54ng7m92	745	26	of	of	IN
cord-262445-54ng7m92	745	27	HDAC	HDAC	NNP
cord-262445-54ng7m92	745	28	inhibitors	inhibitor	NNS
cord-262445-54ng7m92	745	29	(	(	-LRB-
cord-262445-54ng7m92	745	30	HDACi	HDACi	NNS
cord-262445-54ng7m92	745	31	)	)	-RRB-
cord-262445-54ng7m92	745	32	on	on	IN
cord-262445-54ng7m92	745	33	DMD	DMD	NNP
cord-262445-54ng7m92	745	34	muscles	muscle	NNS
cord-262445-54ng7m92	745	35	.	.	.
cord-262445-54ng7m92	746	1	FAP	fap	VB
cord-262445-54ng7m92	746	2	-	-	HYPH
cord-262445-54ng7m92	746	3	derived	derive	VBN
cord-262445-54ng7m92	746	4	EVs	ev	NNS
cord-262445-54ng7m92	746	5	mediate	mediate	VBP
cord-262445-54ng7m92	746	6	microRNA	microRNA	NNP
cord-262445-54ng7m92	746	7	transfer	transfer	NN
cord-262445-54ng7m92	746	8	to	to	IN
cord-262445-54ng7m92	746	9	MuSCs	MuSCs	NNP
cord-262445-54ng7m92	746	10	,	,	,
cord-262445-54ng7m92	746	11	and	and	CC
cord-262445-54ng7m92	746	12	that	that	IN
cord-262445-54ng7m92	746	13	exposure	exposure	NN
cord-262445-54ng7m92	746	14	of	of	IN
cord-262445-54ng7m92	746	15	dystrophic	dystrophic	JJ
cord-262445-54ng7m92	746	16	FAPs	fap	NNS
cord-262445-54ng7m92	746	17	to	to	IN
cord-262445-54ng7m92	746	18	HDAC	HDAC	NNP
cord-262445-54ng7m92	746	19	inhibitors	inhibitor	NNS
cord-262445-54ng7m92	746	20	(	(	-LRB-
cord-262445-54ng7m92	746	21	HDACi	HDACi	NNS
cord-262445-54ng7m92	746	22	)	)	-RRB-
cord-262445-54ng7m92	746	23	increases	increase	VBZ
cord-262445-54ng7m92	746	24	the	the	DT
cord-262445-54ng7m92	746	25	intra	intra	JJ
cord-262445-54ng7m92	746	26	-	-	JJ
cord-262445-54ng7m92	746	27	EV	ev	JJ
cord-262445-54ng7m92	746	28	levels	level	NNS
cord-262445-54ng7m92	746	29	of	of	IN
cord-262445-54ng7m92	746	30	a	a	DT
cord-262445-54ng7m92	746	31	subset	subset	NN
cord-262445-54ng7m92	746	32	of	of	IN
cord-262445-54ng7m92	746	33	microRNAs	microRNAs	NNPS
cord-262445-54ng7m92	746	34	(	(	-LRB-
cord-262445-54ng7m92	746	35	miRs	miRs	NNP
cord-262445-54ng7m92	746	36	)	)	-RRB-
cord-262445-54ng7m92	746	37	,	,	,
cord-262445-54ng7m92	746	38	which	which	WDT
cord-262445-54ng7m92	746	39	cooperatively	cooperatively	RB
cord-262445-54ng7m92	746	40	target	target	VBP
cord-262445-54ng7m92	746	41	biological	biological	JJ
cord-262445-54ng7m92	746	42	processes	process	NNS
cord-262445-54ng7m92	746	43	of	of	IN
cord-262445-54ng7m92	746	44	therapeutic	therapeutic	JJ
cord-262445-54ng7m92	746	45	interest	interest	NN
cord-262445-54ng7m92	746	46	,	,	,
cord-262445-54ng7m92	746	47	including	include	VBG
cord-262445-54ng7m92	746	48	regeneration	regeneration	NN
cord-262445-54ng7m92	746	49	,	,	,
cord-262445-54ng7m92	746	50	fibrosis	fibrosis	NN
cord-262445-54ng7m92	746	51	and	and	CC
cord-262445-54ng7m92	746	52	inflammation	inflammation	NN
cord-262445-54ng7m92	746	53	.	.	.
cord-262445-54ng7m92	747	1	In	in	IN
cord-262445-54ng7m92	747	2	particular	particular	JJ
cord-262445-54ng7m92	747	3	,	,	,
cord-262445-54ng7m92	747	4	increased	increase	VBN
cord-262445-54ng7m92	747	5	levels	level	NNS
cord-262445-54ng7m92	747	6	of	of	IN
cord-262445-54ng7m92	747	7	miR206	mir206	CD
cord-262445-54ng7m92	747	8	in	in	IN
cord-262445-54ng7m92	747	9	EVs	ev	NNS
cord-262445-54ng7m92	747	10	released	release	VBN
cord-262445-54ng7m92	747	11	from	from	IN
cord-262445-54ng7m92	747	12	FAPs	fap	NNS
cord-262445-54ng7m92	747	13	of	of	IN
cord-262445-54ng7m92	747	14	muscles	muscle	NNS
cord-262445-54ng7m92	747	15	from	from	IN
cord-262445-54ng7m92	747	16	DMD	DMD	NNP
cord-262445-54ng7m92	747	17	patients	patient	NNS
cord-262445-54ng7m92	747	18	or	or	CC
cord-262445-54ng7m92	747	19	mdx	mdx	NNP
cord-262445-54ng7m92	747	20	mice	mouse	NNS
cord-262445-54ng7m92	747	21	exposed	expose	VBN
cord-262445-54ng7m92	747	22	to	to	IN
cord-262445-54ng7m92	747	23	HDACi	HDACi	NNS
cord-262445-54ng7m92	747	24	correlated	correlate	VBN
cord-262445-54ng7m92	747	25	with	with	IN
cord-262445-54ng7m92	747	26	improvement	improvement	NN
cord-262445-54ng7m92	747	27	of	of	IN
cord-262445-54ng7m92	747	28	key	key	JJ
cord-262445-54ng7m92	747	29	histological	histological	JJ
cord-262445-54ng7m92	747	30	parameters	parameter	NNS
cord-262445-54ng7m92	747	31	,	,	,
cord-262445-54ng7m92	747	32	such	such	JJ
cord-262445-54ng7m92	747	33	as	as	IN
cord-262445-54ng7m92	747	34	compensatory	compensatory	JJ
cord-262445-54ng7m92	747	35	regeneration	regeneration	NN
cord-262445-54ng7m92	747	36	and	and	CC
cord-262445-54ng7m92	747	37	inhibition	inhibition	NN
cord-262445-54ng7m92	747	38	of	of	IN
cord-262445-54ng7m92	747	39	fibrosis	fibrosis	NN
cord-262445-54ng7m92	747	40	.	.	.
cord-262445-54ng7m92	748	1	We	-PRON-	PRP
cord-262445-54ng7m92	748	2	found	find	VBD
cord-262445-54ng7m92	748	3	that	that	IN
cord-262445-54ng7m92	748	4	EVs	ev	NNS
cord-262445-54ng7m92	748	5	from	from	IN
cord-262445-54ng7m92	748	6	HDACi	HDACi	NNS
cord-262445-54ng7m92	748	7	-	-	HYPH
cord-262445-54ng7m92	748	8	treated	treat	VBN
cord-262445-54ng7m92	748	9	dystrophic	dystrophic	NN
cord-262445-54ng7m92	748	10	FAPs	fap	NNS
cord-262445-54ng7m92	748	11	stimulated	stimulate	VBD
cord-262445-54ng7m92	748	12	MuSC	MuSC	NNP
cord-262445-54ng7m92	748	13	activation	activation	NN
cord-262445-54ng7m92	748	14	and	and	CC
cord-262445-54ng7m92	748	15	expansion	expansion	NN
cord-262445-54ng7m92	748	16	ex	ex	FW
cord-262445-54ng7m92	748	17	vivo	vivo	NN
cord-262445-54ng7m92	748	18	,	,	,
cord-262445-54ng7m92	748	19	and	and	CC
cord-262445-54ng7m92	748	20	promoted	promote	VBD
cord-262445-54ng7m92	748	21	regeneration	regeneration	NN
cord-262445-54ng7m92	748	22	,	,	,
cord-262445-54ng7m92	748	23	while	while	IN
cord-262445-54ng7m92	748	24	inhibiting	inhibit	VBG
cord-262445-54ng7m92	748	25	fibrosis	fibrosis	NN
cord-262445-54ng7m92	748	26	and	and	CC
cord-262445-54ng7m92	748	27	inflammation	inflammation	NN
cord-262445-54ng7m92	748	28	of	of	IN
cord-262445-54ng7m92	748	29	dystrophic	dystrophic	JJ
cord-262445-54ng7m92	748	30	muscles	muscle	NNS
cord-262445-54ng7m92	748	31	,	,	,
cord-262445-54ng7m92	748	32	upon	upon	IN
cord-262445-54ng7m92	748	33	intramuscular	intramuscular	JJ
cord-262445-54ng7m92	748	34	transplantation	transplantation	NN
cord-262445-54ng7m92	748	35	,	,	,
cord-262445-54ng7m92	748	36	in	in	IN
cord-262445-54ng7m92	748	37	vivo	vivo	NN
cord-262445-54ng7m92	748	38	.	.	.
cord-262445-54ng7m92	749	1	These	these	DT
cord-262445-54ng7m92	749	2	data	datum	NNS
cord-262445-54ng7m92	749	3	reveal	reveal	VBP
cord-262445-54ng7m92	749	4	a	a	DT
cord-262445-54ng7m92	749	5	potential	potential	NN
cord-262445-54ng7m92	749	6	for	for	IN
cord-262445-54ng7m92	749	7	pharmacological	pharmacological	JJ
cord-262445-54ng7m92	749	8	modulation	modulation	NN
cord-262445-54ng7m92	749	9	of	of	IN
cord-262445-54ng7m92	749	10	FAP	fap	NN
cord-262445-54ng7m92	749	11	-	-	HYPH
cord-262445-54ng7m92	749	12	derived	derive	VBN
cord-262445-54ng7m92	749	13	EV	EV	NNP
cord-262445-54ng7m92	749	14	's	's	POS
cord-262445-54ng7m92	749	15	content	content	NN
cord-262445-54ng7m92	749	16	as	as	IN
cord-262445-54ng7m92	749	17	novel	novel	JJ
cord-262445-54ng7m92	749	18	strategy	strategy	NN
cord-262445-54ng7m92	749	19	for	for	IN
cord-262445-54ng7m92	749	20	local	local	JJ
cord-262445-54ng7m92	749	21	therapeutic	therapeutic	JJ
cord-262445-54ng7m92	749	22	interventions	intervention	NNS
cord-262445-54ng7m92	749	23	in	in	IN
cord-262445-54ng7m92	749	24	muscular	muscular	JJ
cord-262445-54ng7m92	749	25	diseases	disease	NNS
cord-262445-54ng7m92	749	26	.	.	.
cord-262445-54ng7m92	750	1	Sarcopenia	Sarcopenia	NNP
cord-262445-54ng7m92	750	2	is	be	VBZ
cord-262445-54ng7m92	750	3	the	the	DT
cord-262445-54ng7m92	750	4	age	age	NN
cord-262445-54ng7m92	750	5	-	-	HYPH
cord-262445-54ng7m92	750	6	related	relate	VBN
cord-262445-54ng7m92	750	7	loss	loss	NN
cord-262445-54ng7m92	750	8	of	of	IN
cord-262445-54ng7m92	750	9	muscle	muscle	NN
cord-262445-54ng7m92	750	10	mass	mass	NN
cord-262445-54ng7m92	750	11	,	,	,
cord-262445-54ng7m92	750	12	strength	strength	NN
cord-262445-54ng7m92	750	13	and	and	CC
cord-262445-54ng7m92	750	14	function	function	NN
cord-262445-54ng7m92	750	15	.	.	.
cord-262445-54ng7m92	751	1	Muscle	muscle	NN
cord-262445-54ng7m92	751	2	mass	mass	JJ
cord-262445-54ng7m92	751	3	decrease	decrease	NN
cord-262445-54ng7m92	751	4	is	be	VBZ
cord-262445-54ng7m92	751	5	directly	directly	RB
cord-262445-54ng7m92	751	6	responsible	responsible	JJ
cord-262445-54ng7m92	751	7	for	for	IN
cord-262445-54ng7m92	751	8	functional	functional	JJ
cord-262445-54ng7m92	751	9	impairment	impairment	NN
cord-262445-54ng7m92	751	10	with	with	IN
cord-262445-54ng7m92	751	11	loss	loss	NN
cord-262445-54ng7m92	751	12	of	of	IN
cord-262445-54ng7m92	751	13	strength	strength	NN
cord-262445-54ng7m92	751	14	,	,	,
cord-262445-54ng7m92	751	15	increased	increase	VBN
cord-262445-54ng7m92	751	16	likelihood	likelihood	NN
cord-262445-54ng7m92	751	17	of	of	IN
cord-262445-54ng7m92	751	18	falls	fall	NNS
cord-262445-54ng7m92	751	19	and	and	CC
cord-262445-54ng7m92	751	20	loss	loss	NN
cord-262445-54ng7m92	751	21	of	of	IN
cord-262445-54ng7m92	751	22	autonomy	autonomy	NN
cord-262445-54ng7m92	751	23	.	.	.
cord-262445-54ng7m92	752	1	Satellite	satellite	NN
cord-262445-54ng7m92	752	2	cells	cell	NNS
cord-262445-54ng7m92	752	3	are	be	VBP
cord-262445-54ng7m92	752	4	myogenic	myogenic	JJ
cord-262445-54ng7m92	752	5	progenitors	progenitor	NNS
cord-262445-54ng7m92	752	6	and	and	CC
cord-262445-54ng7m92	752	7	sarcopenia	sarcopenia	NN
cord-262445-54ng7m92	752	8	is	be	VBZ
cord-262445-54ng7m92	752	9	predicted	predict	VBN
cord-262445-54ng7m92	752	10	to	to	TO
cord-262445-54ng7m92	752	11	be	be	VB
cord-262445-54ng7m92	752	12	the	the	DT
cord-262445-54ng7m92	752	13	result	result	NN
cord-262445-54ng7m92	752	14	of	of	IN
cord-262445-54ng7m92	752	15	reduced	reduce	VBN
cord-262445-54ng7m92	752	16	satellite	satellite	NN
cord-262445-54ng7m92	752	17	cell	cell	NN
cord-262445-54ng7m92	752	18	number	number	NN
cord-262445-54ng7m92	752	19	and/or	and/or	CC
cord-262445-54ng7m92	752	20	function	function	NN
cord-262445-54ng7m92	752	21	.	.	.
cord-262445-54ng7m92	753	1	Despite	despite	IN
cord-262445-54ng7m92	753	2	several	several	JJ
cord-262445-54ng7m92	753	3	investigations	investigation	NNS
cord-262445-54ng7m92	753	4	,	,	,
cord-262445-54ng7m92	753	5	the	the	DT
cord-262445-54ng7m92	753	6	precise	precise	JJ
cord-262445-54ng7m92	753	7	molecular	molecular	JJ
cord-262445-54ng7m92	753	8	mechanisms	mechanism	NNS
cord-262445-54ng7m92	753	9	underlying	underlie	VBG
cord-262445-54ng7m92	753	10	stem	stem	NN
cord-262445-54ng7m92	753	11	cell	cell	NN
cord-262445-54ng7m92	753	12	dysfunctions	dysfunction	NNS
cord-262445-54ng7m92	753	13	in	in	IN
cord-262445-54ng7m92	753	14	the	the	DT
cord-262445-54ng7m92	753	15	age	age	NN
cord-262445-54ng7m92	753	16	-	-	HYPH
cord-262445-54ng7m92	753	17	associated	associate	VBN
cord-262445-54ng7m92	753	18	muscle	muscle	NN
cord-262445-54ng7m92	753	19	decline	decline	NN
cord-262445-54ng7m92	753	20	remains	remain	VBZ
cord-262445-54ng7m92	753	21	unclear	unclear	JJ
cord-262445-54ng7m92	753	22	.	.	.
cord-262445-54ng7m92	754	1	Recently	recently	RB
cord-262445-54ng7m92	754	2	cutting	cut	VBG
cord-262445-54ng7m92	754	3	-	-	HYPH
cord-262445-54ng7m92	754	4	edge	edge	NN
cord-262445-54ng7m92	754	5	studies	study	NNS
cord-262445-54ng7m92	754	6	highlighted	highlight	VBD
cord-262445-54ng7m92	754	7	the	the	DT
cord-262445-54ng7m92	754	8	role	role	NN
cord-262445-54ng7m92	754	9	of	of	IN
cord-262445-54ng7m92	754	10	epigenetic	epigenetic	JJ
cord-262445-54ng7m92	754	11	mechanisms	mechanism	NNS
cord-262445-54ng7m92	754	12	in	in	IN
cord-262445-54ng7m92	754	13	muscle	muscle	NN
cord-262445-54ng7m92	754	14	senescence	senescence	NN
cord-262445-54ng7m92	754	15	and	and	CC
cord-262445-54ng7m92	754	16	sarcopenia	sarcopenia	NN
cord-262445-54ng7m92	754	17	.	.	.
cord-262445-54ng7m92	755	1	Among	among	IN
cord-262445-54ng7m92	755	2	the	the	DT
cord-262445-54ng7m92	755	3	biological	biological	JJ
cord-262445-54ng7m92	755	4	mechanisms	mechanism	NNS
cord-262445-54ng7m92	755	5	involved	involve	VBN
cord-262445-54ng7m92	755	6	in	in	IN
cord-262445-54ng7m92	755	7	the	the	DT
cord-262445-54ng7m92	755	8	regulation	regulation	NN
cord-262445-54ng7m92	755	9	of	of	IN
cord-262445-54ng7m92	755	10	heterochromatin	heterochromatin	NN
cord-262445-54ng7m92	755	11	conformation	conformation	NN
cord-262445-54ng7m92	755	12	,	,	,
cord-262445-54ng7m92	755	13	we	-PRON-	PRP
cord-262445-54ng7m92	755	14	recently	recently	RB
cord-262445-54ng7m92	755	15	described	describe	VBD
cord-262445-54ng7m92	755	16	a	a	DT
cord-262445-54ng7m92	755	17	functional	functional	JJ
cord-262445-54ng7m92	755	18	and	and	CC
cord-262445-54ng7m92	755	19	evolutionary	evolutionary	JJ
cord-262445-54ng7m92	755	20	conserved	conserve	VBN
cord-262445-54ng7m92	755	21	crosstalk	crosstalk	NN
cord-262445-54ng7m92	755	22	between	between	IN
cord-262445-54ng7m92	755	23	the	the	DT
cord-262445-54ng7m92	755	24	nuclear	nuclear	JJ
cord-262445-54ng7m92	755	25	Lamin	Lamin	NNP
cord-262445-54ng7m92	755	26	A	A	NNP
cord-262445-54ng7m92	755	27	/	/	SYM
cord-262445-54ng7m92	755	28	C	C	NNP
cord-262445-54ng7m92	755	29	and	and	CC
cord-262445-54ng7m92	755	30	the	the	DT
cord-262445-54ng7m92	755	31	PcG	pcg	NN
cord-262445-54ng7m92	755	32	proteins	protein	NNS
cord-262445-54ng7m92	755	33	.	.	.
cord-262445-54ng7m92	756	1	This	this	DT
cord-262445-54ng7m92	756	2	functional	functional	JJ
cord-262445-54ng7m92	756	3	interplay	interplay	NN
cord-262445-54ng7m92	756	4	is	be	VBZ
cord-262445-54ng7m92	756	5	required	require	VBN
cord-262445-54ng7m92	756	6	for	for	IN
cord-262445-54ng7m92	756	7	the	the	DT
cord-262445-54ng7m92	756	8	maintenance	maintenance	NN
cord-262445-54ng7m92	756	9	of	of	IN
cord-262445-54ng7m92	756	10	the	the	DT
cord-262445-54ng7m92	756	11	PcG	pcg	NN
cord-262445-54ng7m92	756	12	repressive	repressive	JJ
cord-262445-54ng7m92	756	13	functions	function	NNS
cord-262445-54ng7m92	756	14	at	at	IN
cord-262445-54ng7m92	756	15	the	the	DT
cord-262445-54ng7m92	756	16	onset	onset	NN
cord-262445-54ng7m92	756	17	of	of	IN
cord-262445-54ng7m92	756	18	muscle	muscle	NN
cord-262445-54ng7m92	756	19	differentiation	differentiation	NN
cord-262445-54ng7m92	756	20	-49	-49	NNP
cord-262445-54ng7m92	757	1	-and	-and	:
cord-262445-54ng7m92	757	2	does	do	VBZ
cord-262445-54ng7m92	757	3	not	not	RB
cord-262445-54ng7m92	757	4	work	work	VB
cord-262445-54ng7m92	757	5	properly	properly	RB
cord-262445-54ng7m92	757	6	in	in	IN
cord-262445-54ng7m92	757	7	the	the	DT
cord-262445-54ng7m92	757	8	pathological	pathological	JJ
cord-262445-54ng7m92	757	9	Emery	Emery	NNP
cord-262445-54ng7m92	757	10	Dreifuss	Dreifuss	NNP
cord-262445-54ng7m92	757	11	muscular	muscular	JJ
cord-262445-54ng7m92	757	12	dystrophy	dystrophy	NN
cord-262445-54ng7m92	757	13	.	.	.
cord-262445-54ng7m92	758	1	Based	base	VBN
cord-262445-54ng7m92	758	2	on	on	IN
cord-262445-54ng7m92	758	3	these	these	DT
cord-262445-54ng7m92	758	4	findings	finding	NNS
cord-262445-54ng7m92	758	5	we	-PRON-	PRP
cord-262445-54ng7m92	758	6	hypothesize	hypothesize	VBP
cord-262445-54ng7m92	758	7	that	that	IN
cord-262445-54ng7m92	758	8	in	in	IN
cord-262445-54ng7m92	758	9	aged	aged	JJ
cord-262445-54ng7m92	758	10	satellite	satellite	NN
cord-262445-54ng7m92	758	11	cells	cell	NNS
cord-262445-54ng7m92	758	12	an	an	DT
cord-262445-54ng7m92	758	13	altered	alter	VBN
cord-262445-54ng7m92	758	14	Lamin	Lamin	NNP
cord-262445-54ng7m92	758	15	/	/	SYM
cord-262445-54ng7m92	758	16	PcG	pcg	NN
cord-262445-54ng7m92	758	17	axis	axis	NN
cord-262445-54ng7m92	758	18	could	could	MD
cord-262445-54ng7m92	758	19	determine	determine	VB
cord-262445-54ng7m92	758	20	a	a	DT
cord-262445-54ng7m92	758	21	pathological	pathological	JJ
cord-262445-54ng7m92	758	22	remodelling	remodelling	NN
cord-262445-54ng7m92	758	23	of	of	IN
cord-262445-54ng7m92	758	24	the	the	DT
cord-262445-54ng7m92	758	25	heterochromatin	heterochromatin	NN
cord-262445-54ng7m92	758	26	organization	organization	NN
cord-262445-54ng7m92	758	27	leading	lead	VBG
cord-262445-54ng7m92	758	28	to	to	IN
cord-262445-54ng7m92	758	29	the	the	DT
cord-262445-54ng7m92	758	30	loss	loss	NN
cord-262445-54ng7m92	758	31	of	of	IN
cord-262445-54ng7m92	758	32	muscle	muscle	NN
cord-262445-54ng7m92	758	33	stem	stem	NN
cord-262445-54ng7m92	758	34	cell	cell	NN
cord-262445-54ng7m92	758	35	functions	function	NNS
cord-262445-54ng7m92	758	36	.	.	.
cord-262445-54ng7m92	759	1	Taking	take	VBG
cord-262445-54ng7m92	759	2	advantage	advantage	NN
cord-262445-54ng7m92	759	3	of	of	IN
cord-262445-54ng7m92	759	4	a	a	DT
cord-262445-54ng7m92	759	5	new	new	JJ
cord-262445-54ng7m92	759	6	technique	technique	NN
cord-262445-54ng7m92	759	7	developed	develop	VBN
cord-262445-54ng7m92	759	8	in	in	IN
cord-262445-54ng7m92	759	9	our	-PRON-	PRP$
cord-262445-54ng7m92	759	10	laboratory	laboratory	NN
cord-262445-54ng7m92	759	11	,	,	,
cord-262445-54ng7m92	759	12	named	name	VBN
cord-262445-54ng7m92	759	13	Sequential	Sequential	NNP
cord-262445-54ng7m92	759	14	Analysis	Analysis	NNP
cord-262445-54ng7m92	759	15	of	of	IN
cord-262445-54ng7m92	759	16	MacroMolecules	MacroMolecules	NNP
cord-262445-54ng7m92	759	17	accessibilitY	accessibilitY	NNP
cord-262445-54ng7m92	760	1	(	(	-LRB-
cord-262445-54ng7m92	760	2	SAMMY	SAMMY	NNP
cord-262445-54ng7m92	760	3	-	-	HYPH
cord-262445-54ng7m92	760	4	seq	seq	NNP
cord-262445-54ng7m92	760	5	)	)	-RRB-
cord-262445-54ng7m92	761	1	we	-PRON-	PRP
cord-262445-54ng7m92	761	2	were	be	VBD
cord-262445-54ng7m92	761	3	able	able	JJ
cord-262445-54ng7m92	761	4	to	to	TO
cord-262445-54ng7m92	761	5	map	map	VB
cord-262445-54ng7m92	761	6	lamina	lamina	JJ
cord-262445-54ng7m92	761	7	associated	associate	VBN
cord-262445-54ng7m92	761	8	heterochromatic	heterochromatic	JJ
cord-262445-54ng7m92	761	9	regions	region	NNS
cord-262445-54ng7m92	761	10	in	in	IN
cord-262445-54ng7m92	761	11	small	small	JJ
cord-262445-54ng7m92	761	12	amount	amount	NN
cord-262445-54ng7m92	761	13	of	of	IN
cord-262445-54ng7m92	761	14	primary	primary	JJ
cord-262445-54ng7m92	761	15	cells	cell	NNS
cord-262445-54ng7m92	761	16	.	.	.
cord-262445-54ng7m92	762	1	The	the	DT
cord-262445-54ng7m92	762	2	protocol	protocol	NN
cord-262445-54ng7m92	762	3	is	be	VBZ
cord-262445-54ng7m92	762	4	based	base	VBN
cord-262445-54ng7m92	762	5	on	on	IN
cord-262445-54ng7m92	762	6	the	the	DT
cord-262445-54ng7m92	762	7	sequential	sequential	JJ
cord-262445-54ng7m92	762	8	extraction	extraction	NN
cord-262445-54ng7m92	762	9	of	of	IN
cord-262445-54ng7m92	762	10	multiple	multiple	JJ
cord-262445-54ng7m92	762	11	chromatin	chromatin	NN
cord-262445-54ng7m92	762	12	fractions	fraction	NNS
cord-262445-54ng7m92	762	13	,	,	,
cord-262445-54ng7m92	762	14	corresponding	correspond	VBG
cord-262445-54ng7m92	762	15	to	to	IN
cord-262445-54ng7m92	762	16	increasingly	increasingly	RB
cord-262445-54ng7m92	762	17	compacted	compact	VBN
cord-262445-54ng7m92	762	18	and	and	CC
cord-262445-54ng7m92	762	19	less	less	RBR
cord-262445-54ng7m92	762	20	accessible	accessible	JJ
cord-262445-54ng7m92	762	21	chromatin	chromatin	NN
cord-262445-54ng7m92	762	22	regions	region	NNS
cord-262445-54ng7m92	762	23	,	,	,
cord-262445-54ng7m92	762	24	which	which	WDT
cord-262445-54ng7m92	762	25	are	be	VBP
cord-262445-54ng7m92	762	26	mapped	map	VBN
cord-262445-54ng7m92	762	27	along	along	IN
cord-262445-54ng7m92	762	28	the	the	DT
cord-262445-54ng7m92	762	29	genome	genome	NN
cord-262445-54ng7m92	762	30	using	use	VBG
cord-262445-54ng7m92	762	31	high	high	JJ
cord-262445-54ng7m92	762	32	-	-	HYPH
cord-262445-54ng7m92	762	33	throughput	throughput	NN
cord-262445-54ng7m92	762	34	sequencing	sequencing	NN
cord-262445-54ng7m92	762	35	.	.	.
cord-262445-54ng7m92	763	1	We	-PRON-	PRP
cord-262445-54ng7m92	763	2	will	will	MD
cord-262445-54ng7m92	763	3	show	show	VB
cord-262445-54ng7m92	763	4	results	result	NNS
cord-262445-54ng7m92	763	5	obtained	obtain	VBN
cord-262445-54ng7m92	763	6	in	in	IN
cord-262445-54ng7m92	763	7	muscle	muscle	NN
cord-262445-54ng7m92	763	8	tissue	tissue	NN
cord-262445-54ng7m92	763	9	or	or	CC
cord-262445-54ng7m92	763	10	stem	stem	NN
cord-262445-54ng7m92	763	11	cells	cell	NNS
cord-262445-54ng7m92	763	12	derived	derive	VBN
cord-262445-54ng7m92	763	13	from	from	IN
cord-262445-54ng7m92	763	14	mice	mouse	NNS
cord-262445-54ng7m92	763	15	and	and	CC
cord-262445-54ng7m92	763	16	human	human	NN
cord-262445-54ng7m92	763	17	at	at	IN
cord-262445-54ng7m92	763	18	different	different	JJ
cord-262445-54ng7m92	763	19	stage	stage	NN
cord-262445-54ng7m92	763	20	of	of	IN
cord-262445-54ng7m92	763	21	muscular	muscular	JJ
cord-262445-54ng7m92	763	22	aging	aging	NN
cord-262445-54ng7m92	763	23	and	and	CC
cord-262445-54ng7m92	763	24	sarcopenia	sarcopenia	NN
cord-262445-54ng7m92	763	25	with	with	IN
cord-262445-54ng7m92	763	26	the	the	DT
cord-262445-54ng7m92	763	27	purpose	purpose	NN
cord-262445-54ng7m92	763	28	to	to	TO
cord-262445-54ng7m92	763	29	highlight	highlight	VB
cord-262445-54ng7m92	763	30	age	age	NN
cord-262445-54ng7m92	763	31	-	-	HYPH
cord-262445-54ng7m92	763	32	related	relate	VBN
cord-262445-54ng7m92	763	33	chromatin	chromatin	NN
cord-262445-54ng7m92	763	34	structural	structural	JJ
cord-262445-54ng7m92	763	35	changes	change	NNS
cord-262445-54ng7m92	763	36	,	,	,
cord-262445-54ng7m92	763	37	opening	open	VBG
cord-262445-54ng7m92	763	38	up	up	RP
cord-262445-54ng7m92	763	39	the	the	DT
cord-262445-54ng7m92	763	40	possibility	possibility	NN
cord-262445-54ng7m92	763	41	to	to	TO
cord-262445-54ng7m92	763	42	identify	identify	VB
cord-262445-54ng7m92	763	43	coding	code	VBG
cord-262445-54ng7m92	763	44	and/or	and/or	CC
cord-262445-54ng7m92	763	45	noncoding	noncoding	JJ
cord-262445-54ng7m92	763	46	genomic	genomic	JJ
cord-262445-54ng7m92	763	47	regions	region	NNS
cord-262445-54ng7m92	763	48	,	,	,
cord-262445-54ng7m92	763	49	dependent	dependent	JJ
cord-262445-54ng7m92	763	50	or	or	CC
cord-262445-54ng7m92	763	51	not	not	RB
cord-262445-54ng7m92	763	52	by	by	IN
cord-262445-54ng7m92	763	53	Polycomb	Polycomb	NNP
cord-262445-54ng7m92	763	54	proteins	protein	NNS
cord-262445-54ng7m92	763	55	,	,	,
cord-262445-54ng7m92	763	56	involved	involve	VBN
cord-262445-54ng7m92	763	57	in	in	IN
cord-262445-54ng7m92	763	58	premature	premature	JJ
cord-262445-54ng7m92	763	59	senescence	senescence	NN
cord-262445-54ng7m92	763	60	of	of	IN
cord-262445-54ng7m92	763	61	sarcopenic	sarcopenic	JJ
cord-262445-54ng7m92	763	62	muscles	muscle	NNS
cord-262445-54ng7m92	763	63	.	.	.
cord-262445-54ng7m92	764	1	Telocytes	Telocytes	NNP
cord-262445-54ng7m92	764	2	(	(	-LRB-
cord-262445-54ng7m92	764	3	TCs	TCs	NNP
cord-262445-54ng7m92	764	4	)	)	-RRB-
cord-262445-54ng7m92	764	5	represent	represent	VBP
cord-262445-54ng7m92	764	6	unique	unique	JJ
cord-262445-54ng7m92	764	7	stromal	stromal	JJ
cord-262445-54ng7m92	764	8	cells	cell	NNS
cord-262445-54ng7m92	764	9	characterized	characterize	VBN
cord-262445-54ng7m92	764	10	by	by	IN
cord-262445-54ng7m92	764	11	a	a	DT
cord-262445-54ng7m92	764	12	small	small	JJ
cord-262445-54ng7m92	764	13	cell	cell	NN
cord-262445-54ng7m92	764	14	body	body	NN
cord-262445-54ng7m92	764	15	and	and	CC
cord-262445-54ng7m92	764	16	distinctive	distinctive	JJ
cord-262445-54ng7m92	764	17	extremely	extremely	RB
cord-262445-54ng7m92	764	18	long	long	JJ
cord-262445-54ng7m92	764	19	,	,	,
cord-262445-54ng7m92	764	20	thin	thin	JJ
cord-262445-54ng7m92	764	21	and	and	CC
cord-262445-54ng7m92	764	22	moniliform	moniliform	JJ
cord-262445-54ng7m92	764	23	cytoplasmic	cytoplasmic	JJ
cord-262445-54ng7m92	764	24	extensions	extension	NNS
cord-262445-54ng7m92	764	25	called	call	VBD
cord-262445-54ng7m92	764	26	telopodes	telopode	NNS
cord-262445-54ng7m92	764	27	alternating	alternate	VBG
cord-262445-54ng7m92	764	28	slender	slender	JJ
cord-262445-54ng7m92	764	29	segments	segment	NNS
cord-262445-54ng7m92	764	30	(	(	-LRB-
cord-262445-54ng7m92	764	31	podomers	podomer	NNS
cord-262445-54ng7m92	764	32	)	)	-RRB-
cord-262445-54ng7m92	764	33	with	with	IN
cord-262445-54ng7m92	764	34	dilatations	dilatation	NNS
cord-262445-54ng7m92	764	35	(	(	-LRB-
cord-262445-54ng7m92	764	36	podoms	podoms	NNP
cord-262445-54ng7m92	764	37	)	)	-RRB-
cord-262445-54ng7m92	764	38	.	.	.
cord-262445-54ng7m92	765	1	TCs	tc	NNS
cord-262445-54ng7m92	765	2	have	have	VBP
cord-262445-54ng7m92	765	3	been	be	VBN
cord-262445-54ng7m92	765	4	identified	identify	VBN
cord-262445-54ng7m92	765	5	in	in	IN
cord-262445-54ng7m92	765	6	the	the	DT
cord-262445-54ng7m92	765	7	skeletal	skeletal	JJ
cord-262445-54ng7m92	765	8	muscle	muscle	NN
cord-262445-54ng7m92	765	9	interstitium	interstitium	NN
cord-262445-54ng7m92	765	10	with	with	IN
cord-262445-54ng7m92	765	11	their	-PRON-	PRP$
cord-262445-54ng7m92	765	12	telopodes	telopode	NNS
cord-262445-54ng7m92	765	13	being	be	VBG
cord-262445-54ng7m92	765	14	strategically	strategically	RB
cord-262445-54ng7m92	765	15	positioned	position	VBN
cord-262445-54ng7m92	765	16	in	in	IN
cord-262445-54ng7m92	765	17	the	the	DT
cord-262445-54ng7m92	765	18	close	close	JJ
cord-262445-54ng7m92	765	19	vicinity	vicinity	NN
cord-262445-54ng7m92	765	20	of	of	IN
cord-262445-54ng7m92	765	21	striated	striated	JJ
cord-262445-54ng7m92	765	22	myofiber	myofiber	NNP
cord-262445-54ng7m92	765	23	s	s	NNP
cord-262445-54ng7m92	765	24	with	with	IN
cord-262445-54ng7m92	765	25	regenerative	regenerative	JJ
cord-262445-54ng7m92	765	26	features	feature	NNS
cord-262445-54ng7m92	765	27	,	,	,
cord-262445-54ng7m92	765	28	nerve	nerve	NN
cord-262445-54ng7m92	765	29	endings	ending	NNS
cord-262445-54ng7m92	765	30	,	,	,
cord-262445-54ng7m92	765	31	small	small	JJ
cord-262445-54ng7m92	765	32	blood	blood	NN
cord-262445-54ng7m92	765	33	vessels	vessel	NNS
cord-262445-54ng7m92	765	34	,	,	,
cord-262445-54ng7m92	765	35	and	and	CC
cord-262445-54ng7m92	765	36	often	often	RB
cord-262445-54ng7m92	765	37	of	of	IN
cord-262445-54ng7m92	765	38	resident	resident	JJ
cord-262445-54ng7m92	765	39	muscle	muscle	NN
cord-262445-54ng7m92	765	40	stem	stem	NN
cord-262445-54ng7m92	765	41	cells	cell	NNS
cord-262445-54ng7m92	765	42	,	,	,
cord-262445-54ng7m92	765	43	namely	namely	RB
cord-262445-54ng7m92	765	44	satellite	satellite	NN
cord-262445-54ng7m92	765	45	cells	cell	NNS
cord-262445-54ng7m92	765	46	(	(	-LRB-
cord-262445-54ng7m92	765	47	SCs	sc	NNS
cord-262445-54ng7m92	765	48	)	)	-RRB-
cord-262445-54ng7m92	765	49	.	.	.
cord-262445-54ng7m92	766	1	A	a	DT
cord-262445-54ng7m92	766	2	"	"	``
cord-262445-54ng7m92	766	3	nursing	nursing	NN
cord-262445-54ng7m92	766	4	"	"	''
cord-262445-54ng7m92	766	5	role	role	NN
cord-262445-54ng7m92	766	6	for	for	IN
cord-262445-54ng7m92	766	7	TCs	TCs	NNP
cord-262445-54ng7m92	766	8	in	in	IN
cord-262445-54ng7m92	766	9	SC	SC	NNP
cord-262445-54ng7m92	766	10	-	-	HYPH
cord-262445-54ng7m92	766	11	mediated	mediate	VBN
cord-262445-54ng7m92	766	12	skeletal	skeletal	JJ
cord-262445-54ng7m92	766	13	muscle	muscle	NN
cord-262445-54ng7m92	766	14	regeneration	regeneration	NN
cord-262445-54ng7m92	766	15	has	have	VBZ
cord-262445-54ng7m92	766	16	been	be	VBN
cord-262445-54ng7m92	766	17	supposed	suppose	VBN
cord-262445-54ng7m92	766	18	;	;	:
cord-262445-54ng7m92	766	19	however	however	RB
cord-262445-54ng7m92	766	20	,	,	,
cord-262445-54ng7m92	766	21	to	to	IN
cord-262445-54ng7m92	766	22	date	date	NN
cord-262445-54ng7m92	766	23	there	there	EX
cord-262445-54ng7m92	766	24	is	be	VBZ
cord-262445-54ng7m92	766	25	no	no	DT
cord-262445-54ng7m92	766	26	experimental	experimental	JJ
cord-262445-54ng7m92	766	27	evidence	evidence	NN
cord-262445-54ng7m92	766	28	demonstrating	demonstrate	VBG
cord-262445-54ng7m92	766	29	a	a	DT
cord-262445-54ng7m92	766	30	morpho	morpho	JJ
cord-262445-54ng7m92	766	31	-	-	HYPH
cord-262445-54ng7m92	766	32	functional	functional	JJ
cord-262445-54ng7m92	766	33	interaction	interaction	NN
cord-262445-54ng7m92	766	34	between	between	IN
cord-262445-54ng7m92	766	35	these	these	DT
cord-262445-54ng7m92	766	36	two	two	CD
cord-262445-54ng7m92	766	37	cell	cell	NN
cord-262445-54ng7m92	766	38	types	type	NNS
cord-262445-54ng7m92	766	39	in	in	IN
cord-262445-54ng7m92	766	40	an	an	DT
cord-262445-54ng7m92	766	41	injured	injured	JJ
cord-262445-54ng7m92	766	42	skeletal	skeletal	JJ
cord-262445-54ng7m92	766	43	muscle	muscle	NN
cord-262445-54ng7m92	766	44	.	.	.
cord-262445-54ng7m92	767	1	Hence	hence	RB
cord-262445-54ng7m92	767	2	,	,	,
cord-262445-54ng7m92	767	3	the	the	DT
cord-262445-54ng7m92	767	4	aim	aim	NN
cord-262445-54ng7m92	767	5	of	of	IN
cord-262445-54ng7m92	767	6	present	present	JJ
cord-262445-54ng7m92	767	7	morphological	morphological	JJ
cord-262445-54ng7m92	767	8	study	study	NN
cord-262445-54ng7m92	767	9	was	be	VBD
cord-262445-54ng7m92	767	10	to	to	TO
cord-262445-54ng7m92	767	11	explore	explore	VB
cord-262445-54ng7m92	767	12	the	the	DT
cord-262445-54ng7m92	767	13	presence	presence	NN
cord-262445-54ng7m92	767	14	and	and	CC
cord-262445-54ng7m92	767	15	the	the	DT
cord-262445-54ng7m92	767	16	behavior	behavior	NN
cord-262445-54ng7m92	767	17	of	of	IN
cord-262445-54ng7m92	767	18	TCs	TCs	NNP
cord-262445-54ng7m92	767	19	in	in	IN
cord-262445-54ng7m92	767	20	an	an	DT
cord-262445-54ng7m92	767	21	ex	ex	FW
cord-262445-54ng7m92	767	22	vivo	vivo	NN
cord-262445-54ng7m92	767	23	murine	murine	JJ
cord-262445-54ng7m92	767	24	model	model	NN
cord-262445-54ng7m92	767	25	of	of	IN
cord-262445-54ng7m92	767	26	skeletal	skeletal	JJ
cord-262445-54ng7m92	767	27	muscle	muscle	NN
cord-262445-54ng7m92	767	28	(	(	-LRB-
cord-262445-54ng7m92	767	29	extensor	extensor	NN
cord-262445-54ng7m92	767	30	digitorum	digitorum	NN
cord-262445-54ng7m92	768	1	longus	longus	NNP
cord-262445-54ng7m92	768	2	)	)	-RRB-
cord-262445-54ng7m92	768	3	damage	damage	NN
cord-262445-54ng7m92	768	4	induced	induce	VBN
cord-262445-54ng7m92	768	5	by	by	IN
cord-262445-54ng7m92	768	6	forced	force	VBN
cord-262445-54ng7m92	768	7	eccentric	eccentric	JJ
cord-262445-54ng7m92	768	8	contraction	contraction	NN
cord-262445-54ng7m92	768	9	(	(	-LRB-
cord-262445-54ng7m92	768	10	EC	EC	NNP
cord-262445-54ng7m92	768	11	)	)	-RRB-
cord-262445-54ng7m92	768	12	in	in	IN
cord-262445-54ng7m92	768	13	isometric	isometric	JJ
cord-262445-54ng7m92	768	14	condition	condition	NN
cord-262445-54ng7m92	768	15	,	,	,
cord-262445-54ng7m92	768	16	focusing	focus	VBG
cord-262445-54ng7m92	768	17	on	on	IN
cord-262445-54ng7m92	768	18	their	-PRON-	PRP$
cord-262445-54ng7m92	768	19	interaction	interaction	NN
cord-262445-54ng7m92	768	20	with	with	IN
cord-262445-54ng7m92	768	21	SCs	sc	NNS
cord-262445-54ng7m92	768	22	.	.	.
cord-262445-54ng7m92	769	1	EC	EC	NNP
cord-262445-54ng7m92	769	2	-	-	HYPH
cord-262445-54ng7m92	769	3	damaged	damage	VBN
cord-262445-54ng7m92	769	4	skeletal	skeletal	JJ
cord-262445-54ng7m92	769	5	muscles	muscle	NNS
cord-262445-54ng7m92	769	6	showed	show	VBD
cord-262445-54ng7m92	769	7	evidence	evidence	NN
cord-262445-54ng7m92	769	8	of	of	IN
cord-262445-54ng7m92	769	9	structural	structural	JJ
cord-262445-54ng7m92	769	10	and	and	CC
cord-262445-54ng7m92	769	11	ultrastructural	ultrastructural	JJ
cord-262445-54ng7m92	769	12	injury	injury	NN
cord-262445-54ng7m92	769	13	as	as	IN
cord-262445-54ng7m92	769	14	judged	judge	VBN
cord-262445-54ng7m92	769	15	by	by	IN
cord-262445-54ng7m92	769	16	light	light	JJ
cord-262445-54ng7m92	769	17	microscopic	microscopic	JJ
cord-262445-54ng7m92	769	18	and	and	CC
cord-262445-54ng7m92	769	19	transmission	transmission	NN
cord-262445-54ng7m92	769	20	electron	electron	NN
cord-262445-54ng7m92	769	21	microscopy	microscopy	NN
cord-262445-54ng7m92	769	22	(	(	-LRB-
cord-262445-54ng7m92	769	23	TEM	tem	NN
cord-262445-54ng7m92	769	24	)	)	-RRB-
cord-262445-54ng7m92	769	25	examination	examination	NN
cord-262445-54ng7m92	769	26	and	and	CC
cord-262445-54ng7m92	769	27	along	along	IN
cord-262445-54ng7m92	769	28	with	with	IN
cord-262445-54ng7m92	769	29	significant	significant	JJ
cord-262445-54ng7m92	769	30	electrophysiological	electrophysiological	JJ
cord-262445-54ng7m92	769	31	changes	change	NNS
cord-262445-54ng7m92	769	32	of	of	IN
cord-262445-54ng7m92	769	33	sarcolemnic	sarcolemnic	NNP
cord-262445-54ng7m92	769	34	properties	property	NNS
cord-262445-54ng7m92	769	35	.	.	.
cord-262445-54ng7m92	770	1	Specifically	specifically	RB
cord-262445-54ng7m92	770	2	,	,	,
cord-262445-54ng7m92	770	3	we	-PRON-	PRP
cord-262445-54ng7m92	770	4	observed	observe	VBD
cord-262445-54ng7m92	770	5	a	a	DT
cord-262445-54ng7m92	770	6	resting	rest	VBG
cord-262445-54ng7m92	770	7	membrane	membrane	NN
cord-262445-54ng7m92	770	8	potential	potential	JJ
cord-262445-54ng7m92	770	9	depolarization	depolarization	NN
cord-262445-54ng7m92	770	10	,	,	,
cord-262445-54ng7m92	770	11	an	an	DT
cord-262445-54ng7m92	770	12	increase	increase	NN
cord-262445-54ng7m92	770	13	of	of	IN
cord-262445-54ng7m92	770	14	membrane	membrane	NN
cord-262445-54ng7m92	770	15	capac	capac	NNP
cord-262445-54ng7m92	770	16	itance	itance	NNP
cord-262445-54ng7m92	770	17	,	,	,
cord-262445-54ng7m92	770	18	a	a	DT
cord-262445-54ng7m92	770	19	reduction	reduction	NN
cord-262445-54ng7m92	770	20	of	of	IN
cord-262445-54ng7m92	770	21	membrane	membrane	NN
cord-262445-54ng7m92	770	22	resistance	resistance	NN
cord-262445-54ng7m92	770	23	and	and	CC
cord-262445-54ng7m92	770	24	a	a	DT
cord-262445-54ng7m92	770	25	reduction	reduction	NN
cord-262445-54ng7m92	770	26	of	of	IN
cord-262445-54ng7m92	770	27	the	the	DT
cord-262445-54ng7m92	770	28	outward	outward	JJ
cord-262445-54ng7m92	770	29	K	k	NN
cord-262445-54ng7m92	770	30	+	+	CC
cord-262445-54ng7m92	770	31	current	current	JJ
cord-262445-54ng7m92	770	32	amplitude	amplitude	NN
cord-262445-54ng7m92	770	33	,	,	,
cord-262445-54ng7m92	770	34	leading	lead	VBG
cord-262445-54ng7m92	770	35	to	to	IN
cord-262445-54ng7m92	770	36	an	an	DT
cord-262445-54ng7m92	770	37	overall	overall	JJ
cord-262445-54ng7m92	770	38	alteration	alteration	NN
cord-262445-54ng7m92	770	39	of	of	IN
cord-262445-54ng7m92	770	40	myofiber	myofiber	NN
cord-262445-54ng7m92	770	41	excitability	excitability	NN
cord-262445-54ng7m92	770	42	.	.	.
cord-262445-54ng7m92	771	1	TCs	tc	NNS
cord-262445-54ng7m92	771	2	were	be	VBD
cord-262445-54ng7m92	771	3	identified	identify	VBN
cord-262445-54ng7m92	771	4	in	in	IN
cord-262445-54ng7m92	771	5	both	both	DT
cord-262445-54ng7m92	771	6	control	control	NN
cord-262445-54ng7m92	771	7	and	and	CC
cord-262445-54ng7m92	771	8	EC	EC	NNP
cord-262445-54ng7m92	771	9	-	-	HYPH
cord-262445-54ng7m92	771	10	injured	injure	VBN
cord-262445-54ng7m92	771	11	muscles	muscle	NNS
cord-262445-54ng7m92	771	12	within	within	IN
cord-262445-54ng7m92	771	13	the	the	DT
cord-262445-54ng7m92	771	14	interstitium	interstitium	NN
cord-262445-54ng7m92	771	15	,	,	,
cord-262445-54ng7m92	771	16	alongside	alongside	IN
cord-262445-54ng7m92	771	17	the	the	DT
cord-262445-54ng7m92	771	18	myofibers	myofiber	NNS
cord-262445-54ng7m92	771	19	and	and	CC
cord-262445-54ng7m92	771	20	in	in	IN
cord-262445-54ng7m92	771	21	close	close	JJ
cord-262445-54ng7m92	771	22	vicinity	vicinity	NN
cord-262445-54ng7m92	771	23	of	of	IN
cord-262445-54ng7m92	771	24	vascular	vascular	JJ
cord-262445-54ng7m92	771	25	structures	structure	NNS
cord-262445-54ng7m92	771	26	either	either	RB
cord-262445-54ng7m92	771	27	by	by	IN
cord-262445-54ng7m92	771	28	CD34	CD34	NNP
cord-262445-54ng7m92	771	29	/	/	SYM
cord-262445-54ng7m92	771	30	CD31	CD31	NNP
cord-262445-54ng7m92	771	31	double	double	JJ
cord-262445-54ng7m92	771	32	confocal	confocal	JJ
cord-262445-54ng7m92	771	33	immunofluorescence	immunofluorescence	NN
cord-262445-54ng7m92	771	34	staining	staining	NN
cord-262445-54ng7m92	771	35	(	(	-LRB-
cord-262445-54ng7m92	771	36	i.e.	i.e.	FW
cord-262445-54ng7m92	771	37	TCs	TCs	NNP
cord-262445-54ng7m92	771	38	:	:	:
cord-262445-54ng7m92	771	39	CD34	CD34	NNP
cord-262445-54ng7m92	771	40	+	+	CC
cord-262445-54ng7m92	771	41	/CD31	/CD31	NNP
cord-262445-54ng7m92	771	42	-	-	:
cord-262445-54ng7m92	771	43	;	;	,
cord-262445-54ng7m92	771	44	endothelial	endothelial	JJ
cord-262445-54ng7m92	771	45	cells	cell	NNS
cord-262445-54ng7m92	771	46	:	:	:
cord-262445-54ng7m92	772	1	CD34	CD34	NNP
cord-262445-54ng7m92	772	2	+	+	CC
cord-262445-54ng7m92	772	3	/CD31	/CD31	.
cord-262445-54ng7m92	773	1	+	+	LS
cord-262445-54ng7m92	773	2	)	)	-RRB-
cord-262445-54ng7m92	773	3	or	or	CC
cord-262445-54ng7m92	773	4	by	by	IN
cord-262445-54ng7m92	773	5	TEM	TEM	NNP
cord-262445-54ng7m92	773	6	.	.	.
cord-262445-54ng7m92	774	1	Of	of	IN
cord-262445-54ng7m92	774	2	note	note	VB
cord-262445-54ng7m92	774	3	,	,	,
cord-262445-54ng7m92	774	4	in	in	IN
cord-262445-54ng7m92	774	5	EC	EC	NNP
cord-262445-54ng7m92	774	6	-	-	HYPH
cord-262445-54ng7m92	774	7	damaged	damage	VBN
cord-262445-54ng7m92	774	8	muscles	muscle	NNS
cord-262445-54ng7m92	774	9	,	,	,
cord-262445-54ng7m92	774	10	the	the	DT
cord-262445-54ng7m92	774	11	telopode	telopode	NNP
cord-262445-54ng7m92	774	12	network	network	NN
cord-262445-54ng7m92	774	13	was	be	VBD
cord-262445-54ng7m92	774	14	more	more	RBR
cord-262445-54ng7m92	774	15	extended	extend	VBN
cord-262445-54ng7m92	774	16	and	and	CC
cord-262445-54ng7m92	774	17	arranged	arrange	VBN
cord-262445-54ng7m92	774	18	around	around	RB
cord-262445-54ng7m92	774	19	activated	activate	VBN
cord-262445-54ng7m92	774	20	SCs	sc	NNS
cord-262445-54ng7m92	774	21	displaying	display	VBG
cord-262445-54ng7m92	774	22	nuclear	nuclear	JJ
cord-262445-54ng7m92	774	23	positivity	positivity	NN
cord-262445-54ng7m92	774	24	for	for	IN
cord-262445-54ng7m92	774	25	Pax7	Pax7	NNP
cord-262445-54ng7m92	774	26	,	,	,
cord-262445-54ng7m92	774	27	the	the	DT
cord-262445-54ng7m92	774	28	most	most	RBS
cord-262445-54ng7m92	774	29	reliable	reliable	JJ
cord-262445-54ng7m92	774	30	marker	marker	NN
cord-262445-54ng7m92	774	31	of	of	IN
cord-262445-54ng7m92	774	32	SCs	sc	NNS
cord-262445-54ng7m92	774	33	,	,	,
cord-262445-54ng7m92	774	34	and	and	CC
cord-262445-54ng7m92	774	35	for	for	IN
cord-262445-54ng7m92	774	36	MyoD	MyoD	NNP
cord-262445-54ng7m92	774	37	,	,	,
cord-262445-54ng7m92	774	38	the	the	DT
cord-262445-54ng7m92	774	39	SC	SC	NNP
cord-262445-54ng7m92	774	40	activation	activation	NN
cord-262445-54ng7m92	774	41	marker	marker	NN
cord-262445-54ng7m92	774	42	.	.	.
cord-262445-54ng7m92	775	1	TEM	tem	NN
cord-262445-54ng7m92	775	2	analysis	analysis	NN
cord-262445-54ng7m92	775	3	clearly	clearly	RB
cord-262445-54ng7m92	775	4	demonstrated	demonstrate	VBD
cord-262445-54ng7m92	775	5	the	the	DT
cord-262445-54ng7m92	775	6	presence	presence	NN
cord-262445-54ng7m92	775	7	of	of	IN
cord-262445-54ng7m92	775	8	TCs	TCs	NNP
cord-262445-54ng7m92	775	9	invading	invade	VBG
cord-262445-54ng7m92	775	10	the	the	DT
cord-262445-54ng7m92	775	11	SC	SC	NNP
cord-262445-54ng7m92	775	12	niche	niche	NN
cord-262445-54ng7m92	775	13	passing	pass	VBG
cord-262445-54ng7m92	775	14	with	with	IN
cord-262445-54ng7m92	775	15	their	-PRON-	PRP$
cord-262445-54ng7m92	775	16	telopodes	telopode	NNS
cord-262445-54ng7m92	775	17	a	a	DT
cord-262445-54ng7m92	775	18	broken	break	VBN
cord-262445-54ng7m92	775	19	basal	basal	NN
cord-262445-54ng7m92	775	20	lamina	lamina	NN
cord-262445-54ng7m92	775	21	to	to	TO
cord-262445-54ng7m92	775	22	contact	contact	VB
cord-262445-54ng7m92	775	23	the	the	DT
cord-262445-54ng7m92	775	24	underlying	underlie	VBG
cord-262445-54ng7m92	775	25	activated	activate	VBN
cord-262445-54ng7m92	775	26	SC	SC	NNP
cord-262445-54ng7m92	775	27	that	that	WDT
cord-262445-54ng7m92	775	28	exhibited	exhibit	VBD
cord-262445-54ng7m92	775	29	a	a	DT
cord-262445-54ng7m92	775	30	swollen	swollen	JJ
cord-262445-54ng7m92	775	31	appearance	appearance	NN
cord-262445-54ng7m92	775	32	and	and	CC
cord-262445-54ng7m92	775	33	an	an	DT
cord-262445-54ng7m92	775	34	euchromatic	euchromatic	JJ
cord-262445-54ng7m92	775	35	nucleus	nucleus	NN
cord-262445-54ng7m92	775	36	.	.	.
cord-262445-54ng7m92	776	1	The	the	DT
cord-262445-54ng7m92	776	2	interaction	interaction	NN
cord-262445-54ng7m92	776	3	between	between	IN
cord-262445-54ng7m92	776	4	TCs	TCs	NNP
cord-262445-54ng7m92	776	5	and	and	CC
cord-262445-54ng7m92	776	6	SCs	SCs	NNP
cord-262445-54ng7m92	776	7	was	be	VBD
cord-262445-54ng7m92	776	8	confirmed	confirm	VBN
cord-262445-54ng7m92	776	9	by	by	IN
cord-262445-54ng7m92	776	10	in	in	FW
cord-262445-54ng7m92	776	11	vitro	vitro	FW
cord-262445-54ng7m92	776	12	experiments	experiment	NNS
cord-262445-54ng7m92	776	13	performed	perform	VBN
cord-262445-54ng7m92	776	14	by	by	IN
cord-262445-54ng7m92	776	15	culturing	culture	VBG
cord-262445-54ng7m92	776	16	single	single	JJ
cord-262445-54ng7m92	776	17	living	live	VBG
cord-262445-54ng7m92	776	18	endomysial	endomysial	JJ
cord-262445-54ng7m92	776	19	sheath	sheath	NN
cord-262445-54ng7m92	776	20	-	-	HYPH
cord-262445-54ng7m92	776	21	covered	cover	VBN
cord-262445-54ng7m92	776	22	myofibers	myofiber	NNS
cord-262445-54ng7m92	776	23	isolated	isolate	VBN
cord-262445-54ng7m92	776	24	from	from	IN
cord-262445-54ng7m92	776	25	ECdamaged	ecdamaged	JJ
cord-262445-54ng7m92	776	26	muscle	muscle	NN
cord-262445-54ng7m92	776	27	and	and	CC
cord-262445-54ng7m92	776	28	the	the	DT
cord-262445-54ng7m92	776	29	derived	derive	VBN
cord-262445-54ng7m92	776	30	stromal	stromal	NN
cord-262445-54ng7m92	776	31	cells	cell	NNS
cord-262445-54ng7m92	776	32	/	/	SYM
cord-262445-54ng7m92	776	33	TCs	TCs	NNPS
cord-262445-54ng7m92	776	34	and	and	CC
cord-262445-54ng7m92	776	35	SCs	sc	NNS
cord-262445-54ng7m92	776	36	.	.	.
cord-262445-54ng7m92	777	1	Interestingly	interestingly	RB
cord-262445-54ng7m92	777	2	,	,	,
cord-262445-54ng7m92	777	3	TCs	TCs	NNP
cord-262445-54ng7m92	777	4	from	from	IN
cord-262445-54ng7m92	777	5	EC	EC	NNP
cord-262445-54ng7m92	777	6	-damaged	-damaged	NNP
cord-262445-54ng7m92	777	7	myofibers	myofiber	NNS
cord-262445-54ng7m92	777	8	showed	show	VBD
cord-262445-54ng7m92	777	9	an	an	DT
cord-262445-54ng7m92	777	10	increased	increase	VBN
cord-262445-54ng7m92	777	11	expression	expression	NN
cord-262445-54ng7m92	777	12	of	of	IN
cord-262445-54ng7m92	777	13	vascular	vascular	JJ
cord-262445-54ng7m92	777	14	endothelial	endothelial	JJ
cord-262445-54ng7m92	777	15	growth	growth	NN
cord-262445-54ng7m92	777	16	factor	factor	NN
cord-262445-54ng7m92	777	17	(	(	-LRB-
cord-262445-54ng7m92	777	18	VEGF	VEGF	NNP
cord-262445-54ng7m92	777	19	)	)	-RRB-
cord-262445-54ng7m92	777	20	-A	-A	:
cord-262445-54ng7m92	777	21	,	,	,
cord-262445-54ng7m92	777	22	whose	whose	WP$
cord-262445-54ng7m92	777	23	role	role	NN
cord-262445-54ng7m92	777	24	in	in	IN
cord-262445-54ng7m92	777	25	promoting	promote	VBG
cord-262445-54ng7m92	777	26	myoblast	myoblast	NN
cord-262445-54ng7m92	777	27	proliferation	proliferation	NN
cord-262445-54ng7m92	777	28	and	and	CC
cord-262445-54ng7m92	777	29	differentiation	differentiation	NN
cord-262445-54ng7m92	777	30	is	be	VBZ
cord-262445-54ng7m92	777	31	documented	document	VBN
cord-262445-54ng7m92	777	32	.	.	.
cord-262445-54ng7m92	778	1	SCs	sc	NNS
cord-262445-54ng7m92	778	2	isolated	isolate	VBN
cord-262445-54ng7m92	778	3	from	from	IN
cord-262445-54ng7m92	778	4	the	the	DT
cord-262445-54ng7m92	778	5	same	same	JJ
cord-262445-54ng7m92	778	6	samples	sample	NNS
cord-262445-54ng7m92	778	7	exhibited	exhibit	VBD
cord-262445-54ng7m92	778	8	an	an	DT
cord-262445-54ng7m92	778	9	increased	increase	VBN
cord-262445-54ng7m92	778	10	MyoD	MyoD	NNP
cord-262445-54ng7m92	778	11	expression	expression	NN
cord-262445-54ng7m92	778	12	as	as	RB
cord-262445-54ng7m92	778	13	well	well	RB
cord-262445-54ng7m92	778	14	as	as	IN
cord-262445-54ng7m92	778	15	a	a	DT
cord-262445-54ng7m92	778	16	major	major	JJ
cord-262445-54ng7m92	778	17	tendency	tendency	NN
cord-262445-54ng7m92	778	18	to	to	TO
cord-262445-54ng7m92	778	19	fuse	fuse	VB
cord-262445-54ng7m92	778	20	into	into	IN
cord-262445-54ng7m92	778	21	myotubes	myotube	NNS
cord-262445-54ng7m92	778	22	.	.	.
cord-262445-54ng7m92	779	1	These	these	DT
cord-262445-54ng7m92	779	2	findings	finding	NNS
cord-262445-54ng7m92	779	3	establish	establish	VBP
cord-262445-54ng7m92	779	4	for	for	IN
cord-262445-54ng7m92	779	5	the	the	DT
cord-262445-54ng7m92	779	6	first	first	JJ
cord-262445-54ng7m92	779	7	time	time	NN
cord-262445-54ng7m92	779	8	a	a	DT
cord-262445-54ng7m92	779	9	morphological	morphological	JJ
cord-262445-54ng7m92	779	10	interaction	interaction	NN
cord-262445-54ng7m92	779	11	between	between	IN
cord-262445-54ng7m92	779	12	TCs	TCs	NNP
cord-262445-54ng7m92	779	13	and	and	CC
cord-262445-54ng7m92	779	14	SCs	sc	NNS
cord-262445-54ng7m92	779	15	in	in	IN
cord-262445-54ng7m92	779	16	a	a	DT
cord-262445-54ng7m92	779	17	damaged	damage	VBN
cord-262445-54ng7m92	779	18	muscle	muscle	NN
cord-262445-54ng7m92	779	19	and	and	CC
cord-262445-54ng7m92	779	20	suggest	suggest	VBP
cord-262445-54ng7m92	779	21	a	a	DT
cord-262445-54ng7m92	779	22	juxtacrine	juxtacrine	JJ
cord-262445-54ng7m92	779	23	-	-	HYPH
cord-262445-54ng7m92	779	24	paracrine	paracrine	JJ
cord-262445-54ng7m92	779	25	cell	cell	NN
cord-262445-54ng7m92	779	26	-	-	HYPH
cord-262445-54ng7m92	779	27	cell	cell	NN
cord-262445-54ng7m92	779	28	interaction	interaction	NN
cord-262445-54ng7m92	779	29	involving	involve	VBG
cord-262445-54ng7m92	779	30	VEGF	VEGF	NNP
cord-262445-54ng7m92	779	31	-	-	HYPH
cord-262445-54ng7m92	779	32	A	A	NNP
cord-262445-54ng7m92	779	33	,	,	,
cord-262445-54ng7m92	779	34	which	which	WDT
cord-262445-54ng7m92	779	35	worth	worth	JJ
cord-262445-54ng7m92	779	36	investigating	investigate	VBG
cord-262445-54ng7m92	779	37	further	further	RB
cord-262445-54ng7m92	779	38	.	.	.
cord-262445-54ng7m92	780	1	Facioscapulohumeral	facioscapulohumeral	JJ
cord-262445-54ng7m92	780	2	muscular	muscular	JJ
cord-262445-54ng7m92	780	3	dystrophy	dystrophy	NN
cord-262445-54ng7m92	780	4	(	(	-LRB-
cord-262445-54ng7m92	780	5	FSHD	FSHD	NNP
cord-262445-54ng7m92	780	6	)	)	-RRB-
cord-262445-54ng7m92	780	7	,	,	,
cord-262445-54ng7m92	780	8	the	the	DT
cord-262445-54ng7m92	780	9	third	third	JJ
cord-262445-54ng7m92	780	10	most	most	RBS
cord-262445-54ng7m92	780	11	common	common	JJ
cord-262445-54ng7m92	780	12	hereditary	hereditary	JJ
cord-262445-54ng7m92	780	13	myopathy	myopathy	NN
cord-262445-54ng7m92	780	14	,	,	,
cord-262445-54ng7m92	780	15	is	be	VBZ
cord-262445-54ng7m92	780	16	not	not	RB
cord-262445-54ng7m92	780	17	due	due	JJ
cord-262445-54ng7m92	780	18	to	to	IN
cord-262445-54ng7m92	780	19	a	a	DT
cord-262445-54ng7m92	780	20	classical	classical	JJ
cord-262445-54ng7m92	780	21	mutation	mutation	NN
cord-262445-54ng7m92	780	22	within	within	IN
cord-262445-54ng7m92	780	23	a	a	DT
cord-262445-54ng7m92	780	24	protein	protein	NN
cord-262445-54ng7m92	780	25	-	-	HYPH
cord-262445-54ng7m92	780	26	coding	code	VBG
cord-262445-54ng7m92	780	27	gene	gene	NN
cord-262445-54ng7m92	780	28	.	.	.
cord-262445-54ng7m92	781	1	Instead	instead	RB
cord-262445-54ng7m92	781	2	,	,	,
cord-262445-54ng7m92	781	3	almost	almost	RB
cord-262445-54ng7m92	781	4	all	all	DT
cord-262445-54ng7m92	781	5	FSHD	FSHD	NNP
cord-262445-54ng7m92	781	6	patients	patient	NNS
cord-262445-54ng7m92	781	7	carry	carry	VBP
cord-262445-54ng7m92	781	8	deletions	deletion	NNS
cord-262445-54ng7m92	781	9	of	of	IN
cord-262445-54ng7m92	781	10	an	an	DT
cord-262445-54ng7m92	781	11	integral	integral	JJ
cord-262445-54ng7m92	781	12	number	number	NN
cord-262445-54ng7m92	781	13	of	of	IN
cord-262445-54ng7m92	781	14	tandem	tandem	NN
cord-262445-54ng7m92	781	15	3.3-kilobase	3.3-kilobase	CD
cord-262445-54ng7m92	781	16	repeat	repeat	NN
cord-262445-54ng7m92	781	17	units	unit	NNS
cord-262445-54ng7m92	781	18	,	,	,
cord-262445-54ng7m92	781	19	termed	term	VBN
cord-262445-54ng7m92	781	20	D4Z4	D4Z4	NNP
cord-262445-54ng7m92	781	21	,	,	,
cord-262445-54ng7m92	781	22	located	locate	VBN
cord-262445-54ng7m92	781	23	on	on	IN
cord-262445-54ng7m92	781	24	chromosome	chromosome	NN
cord-262445-54ng7m92	781	25	4q35	4q35	CD
cord-262445-54ng7m92	781	26	.	.	.
cord-262445-54ng7m92	782	1	D4Z4	d4z4	JJ
cord-262445-54ng7m92	782	2	deletion	deletion	NN
cord-262445-54ng7m92	782	3	leads	lead	VBZ
cord-262445-54ng7m92	782	4	to	to	IN
cord-262445-54ng7m92	782	5	modifications	modification	NNS
cord-262445-54ng7m92	782	6	of	of	IN
cord-262445-54ng7m92	782	7	chromatin	chromatin	NN
cord-262445-54ng7m92	782	8	structure	structure	NN
cord-262445-54ng7m92	782	9	and	and	CC
cord-262445-54ng7m92	782	10	inappropriate	inappropriate	JJ
cord-262445-54ng7m92	782	11	overexpression	overexpression	NN
cord-262445-54ng7m92	782	12	of	of	IN
cord-262445-54ng7m92	782	13	4q35	4q35	CD
cord-262445-54ng7m92	782	14	genes	gene	NNS
cord-262445-54ng7m92	782	15	.	.	.
cord-262445-54ng7m92	783	1	Studies	study	NNS
cord-262445-54ng7m92	783	2	have	have	VBP
cord-262445-54ng7m92	783	3	proposed	propose	VBN
cord-262445-54ng7m92	783	4	several	several	JJ
cord-262445-54ng7m92	783	5	candidate	candidate	NN
cord-262445-54ng7m92	783	6	genes	gene	NNS
cord-262445-54ng7m92	783	7	within	within	IN
cord-262445-54ng7m92	783	8	this	this	DT
cord-262445-54ng7m92	783	9	genomic	genomic	JJ
cord-262445-54ng7m92	783	10	region	region	NN
cord-262445-54ng7m92	783	11	and	and	CC
cord-262445-54ng7m92	783	12	several	several	JJ
cord-262445-54ng7m92	783	13	mouse	mouse	NN
cord-262445-54ng7m92	783	14	models	model	NNS
cord-262445-54ng7m92	783	15	have	have	VBP
cord-262445-54ng7m92	783	16	been	be	VBN
cord-262445-54ng7m92	783	17	generated	generate	VBN
cord-262445-54ng7m92	783	18	.	.	.
cord-262445-54ng7m92	784	1	Among	among	IN
cord-262445-54ng7m92	784	2	these	these	DT
cord-262445-54ng7m92	784	3	models	model	NNS
cord-262445-54ng7m92	784	4	,	,	,
cord-262445-54ng7m92	784	5	mice	mouse	NNS
cord-262445-54ng7m92	784	6	overexpressing	overexpresse	VBG
cord-262445-54ng7m92	784	7	Facioscapulohumeral	facioscapulohumeral	JJ
cord-262445-54ng7m92	784	8	muscular	muscular	JJ
cord-262445-54ng7m92	784	9	dystrophy	dystrophy	NN
cord-262445-54ng7m92	784	10	Region	Region	NNP
cord-262445-54ng7m92	784	11	Gene	Gene	NNP
cord-262445-54ng7m92	784	12	1	1	CD
cord-262445-54ng7m92	784	13	(	(	-LRB-
cord-262445-54ng7m92	784	14	FRG1	FRG1	NNP
cord-262445-54ng7m92	784	15	)	)	-RRB-
cord-262445-54ng7m92	784	16	present	present	VBP
cord-262445-54ng7m92	784	17	a	a	DT
cord-262445-54ng7m92	784	18	progressive	progressive	JJ
cord-262445-54ng7m92	784	19	myopathy	myopathy	NN
cord-262445-54ng7m92	784	20	that	that	WDT
cord-262445-54ng7m92	784	21	recapitulate	recapitulate	VBP
cord-262445-54ng7m92	784	22	features	feature	NNS
cord-262445-54ng7m92	784	23	of	of	IN
cord-262445-54ng7m92	784	24	human	human	JJ
cord-262445-54ng7m92	784	25	disease	disease	NN
cord-262445-54ng7m92	784	26	.	.	.
cord-262445-54ng7m92	785	1	FRG1	FRG1	NNP
cord-262445-54ng7m92	785	2	encodes	encode	VBZ
cord-262445-54ng7m92	785	3	for	for	IN
cord-262445-54ng7m92	785	4	an	an	DT
cord-262445-54ng7m92	785	5	RNA	RNA	NNP
cord-262445-54ng7m92	785	6	binding	bind	VBG
cord-262445-54ng7m92	785	7	protein	protein	NN
cord-262445-54ng7m92	785	8	whose	whose	WP$
cord-262445-54ng7m92	785	9	biological	biological	JJ
cord-262445-54ng7m92	785	10	function	function	NN
cord-262445-54ng7m92	785	11	is	be	VBZ
cord-262445-54ng7m92	785	12	not	not	RB
cord-262445-54ng7m92	785	13	well	well	RB
cord-262445-54ng7m92	785	14	understood	understand	VBN
cord-262445-54ng7m92	785	15	.	.	.
cord-262445-54ng7m92	786	1	To	to	TO
cord-262445-54ng7m92	786	2	investigate	investigate	VB
cord-262445-54ng7m92	786	3	the	the	DT
cord-262445-54ng7m92	786	4	molecular	molecular	JJ
cord-262445-54ng7m92	786	5	mechanism	mechanism	NN
cord-262445-54ng7m92	786	6	triggered	trigger	VBN
cord-262445-54ng7m92	786	7	by	by	IN
cord-262445-54ng7m92	786	8	FRG1	FRG1	NNP
cord-262445-54ng7m92	786	9	overexpression	overexpression	NN
cord-262445-54ng7m92	786	10	leading	lead	VBG
cord-262445-54ng7m92	786	11	to	to	IN
cord-262445-54ng7m92	786	12	overt	overt	JJ
cord-262445-54ng7m92	786	13	myopathy	myopathy	NN
cord-262445-54ng7m92	786	14	we	-PRON-	PRP
cord-262445-54ng7m92	786	15	analyzed	analyze	VBD
cord-262445-54ng7m92	786	16	molecular	molecular	JJ
cord-262445-54ng7m92	786	17	changes	change	NNS
cord-262445-54ng7m92	786	18	occurring	occur	VBG
cord-262445-54ng7m92	786	19	during	during	IN
cord-262445-54ng7m92	786	20	disease	disease	NN
cord-262445-54ng7m92	786	21	development	development	NN
cord-262445-54ng7m92	786	22	.	.	.
cord-262445-54ng7m92	787	1	At	at	IN
cord-262445-54ng7m92	787	2	first	first	RB
cord-262445-54ng7m92	787	3	,	,	,
cord-262445-54ng7m92	787	4	gene	gene	NN
cord-262445-54ng7m92	787	5	expression	expression	NN
cord-262445-54ng7m92	787	6	profiles	profile	NNS
cord-262445-54ng7m92	787	7	of	of	IN
cord-262445-54ng7m92	787	8	skeletal	skeletal	JJ
cord-262445-54ng7m92	787	9	muscles	muscle	NNS
cord-262445-54ng7m92	787	10	of	of	IN
cord-262445-54ng7m92	787	11	mice	mouse	NNS
cord-262445-54ng7m92	787	12	overexpressing	overexpresse	VBG
cord-262445-54ng7m92	787	13	increasing	increase	VBG
cord-262445-54ng7m92	787	14	levels	level	NNS
cord-262445-54ng7m92	787	15	of	of	IN
cord-262445-54ng7m92	787	16	FRG1	FRG1	NNP
cord-262445-54ng7m92	787	17	were	be	VBD
cord-262445-54ng7m92	787	18	examined	examine	VBN
cord-262445-54ng7m92	787	19	at	at	IN
cord-262445-54ng7m92	787	20	28	28	CD
cord-262445-54ng7m92	787	21	days	day	NNS
cord-262445-54ng7m92	787	22	(	(	-LRB-
cord-262445-54ng7m92	787	23	dystrophy	dystrophy	NN
cord-262445-54ng7m92	787	24	onset	onset	NN
cord-262445-54ng7m92	787	25	)	)	-RRB-
cord-262445-54ng7m92	787	26	and	and	CC
cord-262445-54ng7m92	787	27	at	at	IN
cord-262445-54ng7m92	787	28	96	96	CD
cord-262445-54ng7m92	787	29	days	day	NNS
cord-262445-54ng7m92	787	30	(	(	-LRB-
cord-262445-54ng7m92	787	31	full	full	JJ
cord-262445-54ng7m92	787	32	dystrophy	dystrophy	NN
cord-262445-54ng7m92	787	33	)	)	-RRB-
cord-262445-54ng7m92	787	34	.	.	.
cord-262445-54ng7m92	788	1	We	-PRON-	PRP
cord-262445-54ng7m92	788	2	found	find	VBD
cord-262445-54ng7m92	788	3	a	a	DT
cord-262445-54ng7m92	788	4	profound	profound	JJ
cord-262445-54ng7m92	788	5	transcriptional	transcriptional	JJ
cord-262445-54ng7m92	788	6	deregulation	deregulation	NN
cord-262445-54ng7m92	788	7	correlating	correlate	VBG
cord-262445-54ng7m92	788	8	the	the	DT
cord-262445-54ng7m92	788	9	severity	severity	NN
cord-262445-54ng7m92	788	10	of	of	IN
cord-262445-54ng7m92	788	11	the	the	DT
cord-262445-54ng7m92	788	12	muscle	muscle	NN
cord-262445-54ng7m92	788	13	phenotype	phenotype	NN
cord-262445-54ng7m92	788	14	and	and	CC
cord-262445-54ng7m92	788	15	FRG1	frg1	JJ
cord-262445-54ng7m92	788	16	expression	expression	NN
cord-262445-54ng7m92	788	17	.	.	.
cord-262445-54ng7m92	789	1	Gene	Gene	NNP
cord-262445-54ng7m92	789	2	Set	Set	NNP
cord-262445-54ng7m92	789	3	Enrichment	Enrichment	NNP
cord-262445-54ng7m92	789	4	Analysis	Analysis	NNP
cord-262445-54ng7m92	789	5	and	and	CC
cord-262445-54ng7m92	789	6	Gene	Gene	NNP
cord-262445-54ng7m92	789	7	Ontology	Ontology	NNP
cord-262445-54ng7m92	789	8	revealed	reveal	VBD
cord-262445-54ng7m92	789	9	alterations	alteration	NNS
cord-262445-54ng7m92	789	10	in	in	IN
cord-262445-54ng7m92	789	11	pathways	pathway	NNS
cord-262445-54ng7m92	789	12	related	relate	VBN
cord-262445-54ng7m92	789	13	to	to	IN
cord-262445-54ng7m92	789	14	muscle	muscle	NN
cord-262445-54ng7m92	789	15	function	function	NN
cord-262445-54ng7m92	789	16	,	,	,
cord-262445-54ng7m92	789	17	energy	energy	NN
cord-262445-54ng7m92	789	18	metabolism	metabolism	NN
cord-262445-54ng7m92	789	19	and	and	CC
cord-262445-54ng7m92	789	20	inflammation	inflammation	NN
cord-262445-54ng7m92	789	21	.	.	.
cord-262445-54ng7m92	790	1	Indeed	indeed	RB
cord-262445-54ng7m92	790	2	,	,	,
cord-262445-54ng7m92	790	3	genes	gene	NNS
cord-262445-54ng7m92	790	4	associated	associate	VBN
cord-262445-54ng7m92	790	5	with	with	IN
cord-262445-54ng7m92	790	6	adult	adult	NN
cord-262445-54ng7m92	790	7	and	and	CC
cord-262445-54ng7m92	790	8	normal	normal	JJ
cord-262445-54ng7m92	790	9	myogenesis	myogenesis	NN
cord-262445-54ng7m92	790	10	were	be	VBD
cord-262445-54ng7m92	790	11	down	down	RB
cord-262445-54ng7m92	790	12	-	-	HYPH
cord-262445-54ng7m92	790	13	regulated	regulate	VBN
cord-262445-54ng7m92	790	14	with	with	IN
cord-262445-54ng7m92	790	15	a	a	DT
cord-262445-54ng7m92	790	16	significant	significant	JJ
cord-262445-54ng7m92	790	17	enrichment	enrichment	NN
cord-262445-54ng7m92	790	18	of	of	IN
cord-262445-54ng7m92	790	19	genes	gene	NNS
cord-262445-54ng7m92	790	20	specifically	specifically	RB
cord-262445-54ng7m92	790	21	expressed	express	VBN
cord-262445-54ng7m92	790	22	during	during	IN
cord-262445-54ng7m92	790	23	embryogenesis	embryogenesis	NN
cord-262445-54ng7m92	790	24	.	.	.
cord-262445-54ng7m92	791	1	By	by	IN
cord-262445-54ng7m92	791	2	contrast	contrast	NN
cord-262445-54ng7m92	791	3	,	,	,
cord-262445-54ng7m92	791	4	we	-PRON-	PRP
cord-262445-54ng7m92	791	5	observed	observe	VBD
cord-262445-54ng7m92	791	6	the	the	DT
cord-262445-54ng7m92	791	7	incremental	incremental	JJ
cord-262445-54ng7m92	791	8	activation	activation	NN
cord-262445-54ng7m92	791	9	of	of	IN
cord-262445-54ng7m92	791	10	inflammatory	inflammatory	JJ
cord-262445-54ng7m92	791	11	pathways	pathway	NNS
cord-262445-54ng7m92	791	12	through	through	IN
cord-262445-54ng7m92	791	13	time	time	NN
cord-262445-54ng7m92	791	14	.	.	.
cord-262445-54ng7m92	792	1	We	-PRON-	PRP
cord-262445-54ng7m92	792	2	found	find	VBD
cord-262445-54ng7m92	792	3	that	that	IN
cord-262445-54ng7m92	792	4	FRG1	FRG1	NNP
cord-262445-54ng7m92	792	5	overexpression	overexpression	NN
cord-262445-54ng7m92	792	6	causes	cause	VBZ
cord-262445-54ng7m92	792	7	the	the	DT
cord-262445-54ng7m92	792	8	global	global	JJ
cord-262445-54ng7m92	792	9	perturbation	perturbation	NN
cord-262445-54ng7m92	792	10	in	in	IN
cord-262445-54ng7m92	792	11	the	the	DT
cord-262445-54ng7m92	792	12	mechanisms	mechanism	NNS
cord-262445-54ng7m92	792	13	that	that	WDT
cord-262445-54ng7m92	792	14	guide	guide	VBP
cord-262445-54ng7m92	792	15	postnatal	postnatal	JJ
cord-262445-54ng7m92	792	16	muscle	muscle	NN
cord-262445-54ng7m92	792	17	maturation	maturation	NN
cord-262445-54ng7m92	792	18	.	.	.
cord-262445-54ng7m92	793	1	This	this	DT
cord-262445-54ng7m92	793	2	process	process	NN
cord-262445-54ng7m92	793	3	includes	include	VBZ
cord-262445-54ng7m92	793	4	the	the	DT
cord-262445-54ng7m92	793	5	anomalous	anomalous	JJ
cord-262445-54ng7m92	793	6	expression	expression	NN
cord-262445-54ng7m92	793	7	of	of	IN
cord-262445-54ng7m92	793	8	embryonic	embryonic	JJ
cord-262445-54ng7m92	793	9	/	/	SYM
cord-262445-54ng7m92	793	10	neonatal	neonatal	JJ
cord-262445-54ng7m92	793	11	proteins	protein	NNS
cord-262445-54ng7m92	793	12	fundamental	fundamental	JJ
cord-262445-54ng7m92	793	13	for	for	IN
cord-262445-54ng7m92	793	14	muscle	muscle	NN
cord-262445-54ng7m92	793	15	structures	structure	NNS
cord-262445-54ng7m92	793	16	and	and	CC
cord-262445-54ng7m92	793	17	metabolic	metabolic	JJ
cord-262445-54ng7m92	793	18	pathways	pathway	NNS
cord-262445-54ng7m92	793	19	,	,	,
cord-262445-54ng7m92	793	20	the	the	DT
cord-262445-54ng7m92	793	21	lack	lack	NN
cord-262445-54ng7m92	793	22	of	of	IN
cord-262445-54ng7m92	793	23	mature	mature	JJ
cord-262445-54ng7m92	793	24	proteins	protein	NNS
cord-262445-54ng7m92	793	25	and	and	CC
cord-262445-54ng7m92	793	26	the	the	DT
cord-262445-54ng7m92	793	27	lag	lag	NN
cord-262445-54ng7m92	793	28	of	of	IN
cord-262445-54ng7m92	793	29	muscle	muscle	NN
cord-262445-54ng7m92	793	30	growth	growth	NN
cord-262445-54ng7m92	793	31	throughout	throughout	IN
cord-262445-54ng7m92	793	32	postnatal	postnatal	JJ
cord-262445-54ng7m92	793	33	life	life	NN
cord-262445-54ng7m92	793	34	.	.	.
cord-262445-54ng7m92	794	1	In	in	IN
cord-262445-54ng7m92	794	2	particular	particular	JJ
cord-262445-54ng7m92	794	3	at	at	IN
cord-262445-54ng7m92	794	4	7	7	CD
cord-262445-54ng7m92	794	5	days	day	NNS
cord-262445-54ng7m92	794	6	and	and	CC
cord-262445-54ng7m92	794	7	14	14	CD
cord-262445-54ng7m92	794	8	days	day	NNS
cord-262445-54ng7m92	794	9	the	the	DT
cord-262445-54ng7m92	794	10	expression	expression	NN
cord-262445-54ng7m92	794	11	of	of	IN
cord-262445-54ng7m92	794	12	the	the	DT
cord-262445-54ng7m92	794	13	embryonic	embryonic	JJ
cord-262445-54ng7m92	794	14	isoforms	isoform	NNS
cord-262445-54ng7m92	794	15	of	of	IN
cord-262445-54ng7m92	794	16	myosin	myosin	NNS
cord-262445-54ng7m92	794	17	remain	remain	VBP
cord-262445-54ng7m92	794	18	high	high	JJ
cord-262445-54ng7m92	794	19	in	in	IN
cord-262445-54ng7m92	794	20	FRG1	FRG1	NNP
cord-262445-54ng7m92	794	21	mice	mouse	NNS
cord-262445-54ng7m92	794	22	instead	instead	RB
cord-262445-54ng7m92	794	23	of	of	IN
cord-262445-54ng7m92	794	24	following	follow	VBG
cord-262445-54ng7m92	794	25	the	the	DT
cord-262445-54ng7m92	794	26	physiological	physiological	JJ
cord-262445-54ng7m92	794	27	down	down	NN
cord-262445-54ng7m92	794	28	-	-	HYPH
cord-262445-54ng7m92	794	29	regulation	regulation	NN
cord-262445-54ng7m92	794	30	occurring	occur	VBG
cord-262445-54ng7m92	794	31	in	in	IN
cord-262445-54ng7m92	794	32	WT	WT	NNP
cord-262445-54ng7m92	794	33	mice	mouse	NNS
cord-262445-54ng7m92	794	34	,	,	,
cord-262445-54ng7m92	794	35	meanwhile	meanwhile	RB
cord-262445-54ng7m92	794	36	the	the	DT
cord-262445-54ng7m92	794	37	expression	expression	NN
cord-262445-54ng7m92	794	38	of	of	IN
cord-262445-54ng7m92	794	39	the	the	DT
cord-262445-54ng7m92	794	40	mature	mature	JJ
cord-262445-54ng7m92	794	41	isoforms	isoform	NNS
cord-262445-54ng7m92	794	42	is	be	VBZ
cord-262445-54ng7m92	794	43	reduced	reduce	VBN
cord-262445-54ng7m92	794	44	.	.	.
cord-262445-54ng7m92	795	1	Starting	start	VBG
cord-262445-54ng7m92	795	2	from	from	IN
cord-262445-54ng7m92	795	3	14	14	CD
cord-262445-54ng7m92	795	4	days	day	NNS
cord-262445-54ng7m92	795	5	we	-PRON-	PRP
cord-262445-54ng7m92	795	6	observed	observe	VBD
cord-262445-54ng7m92	795	7	the	the	DT
cord-262445-54ng7m92	795	8	deceleration	deceleration	NN
cord-262445-54ng7m92	795	9	of	of	IN
cord-262445-54ng7m92	795	10	body	body	NN
cord-262445-54ng7m92	795	11	weight	weight	NN
cord-262445-54ng7m92	795	12	growth	growth	NN
cord-262445-54ng7m92	795	13	curve	curve	NN
cord-262445-54ng7m92	795	14	and	and	CC
cord-262445-54ng7m92	795	15	a	a	DT
cord-262445-54ng7m92	795	16	reduction	reduction	NN
cord-262445-54ng7m92	795	17	of	of	IN
cord-262445-54ng7m92	795	18	muscle	muscle	NN
cord-262445-54ng7m92	795	19	cross	cross	JJ
cord-262445-54ng7m92	795	20	-	-	JJ
cord-262445-54ng7m92	795	21	sectional	sectional	JJ
cord-262445-54ng7m92	795	22	area	area	NN
cord-262445-54ng7m92	795	23	.	.	.
cord-262445-54ng7m92	796	1	Moreover	moreover	RB
cord-262445-54ng7m92	796	2	,	,	,
cord-262445-54ng7m92	796	3	FRG1	frg1	JJ
cord-262445-54ng7m92	796	4	muscles	muscle	NNS
cord-262445-54ng7m92	796	5	displayed	display	VBD
cord-262445-54ng7m92	796	6	the	the	DT
cord-262445-54ng7m92	796	7	significant	significant	JJ
cord-262445-54ng7m92	796	8	reduction	reduction	NN
cord-262445-54ng7m92	796	9	of	of	IN
cord-262445-54ng7m92	796	10	ATP	ATP	NNP
cord-262445-54ng7m92	796	11	and	and	CC
cord-262445-54ng7m92	796	12	the	the	DT
cord-262445-54ng7m92	796	13	phosphocreatine	phosphocreatine	NN
cord-262445-54ng7m92	796	14	in	in	IN
cord-262445-54ng7m92	796	15	association	association	NN
cord-262445-54ng7m92	796	16	with	with	IN
cord-262445-54ng7m92	796	17	the	the	DT
cord-262445-54ng7m92	796	18	transcriptional	transcriptional	JJ
cord-262445-54ng7m92	796	19	downregulation	downregulation	NN
cord-262445-54ng7m92	796	20	of	of	IN
cord-262445-54ng7m92	796	21	Glut4	Glut4	NNP
cord-262445-54ng7m92	796	22	,	,	,
cord-262445-54ng7m92	796	23	HK2	HK2	NNP
cord-262445-54ng7m92	796	24	and	and	CC
cord-262445-54ng7m92	796	25	AldoA.	AldoA.	NNP
cord-262445-54ng7m92	797	1	Our	-PRON-	PRP$
cord-262445-54ng7m92	797	2	results	result	NNS
cord-262445-54ng7m92	797	3	indicate	indicate	VBP
cord-262445-54ng7m92	797	4	that	that	IN
cord-262445-54ng7m92	797	5	FRG1	FRG1	NNP
cord-262445-54ng7m92	797	6	overexpression	overexpression	NN
cord-262445-54ng7m92	797	7	induce	induce	VBP
cord-262445-54ng7m92	797	8	the	the	DT
cord-262445-54ng7m92	797	9	impairment	impairment	NN
cord-262445-54ng7m92	797	10	of	of	IN
cord-262445-54ng7m92	797	11	muscle	muscle	NN
cord-262445-54ng7m92	797	12	maturation	maturation	NN
cord-262445-54ng7m92	797	13	and	and	CC
cord-262445-54ng7m92	797	14	energy	energy	NN
cord-262445-54ng7m92	797	15	metabolism	metabolism	NN
cord-262445-54ng7m92	797	16	that	that	WDT
cord-262445-54ng7m92	797	17	precedes	precede	VBZ
cord-262445-54ng7m92	797	18	dystrophy	dystrophy	NN
cord-262445-54ng7m92	797	19	.	.	.
cord-262445-54ng7m92	798	1	Our	-PRON-	PRP$
cord-262445-54ng7m92	798	2	study	study	NN
cord-262445-54ng7m92	798	3	opens	open	VBZ
cord-262445-54ng7m92	798	4	new	new	JJ
cord-262445-54ng7m92	798	5	perspectives	perspective	NNS
cord-262445-54ng7m92	798	6	on	on	IN
cord-262445-54ng7m92	798	7	the	the	DT
cord-262445-54ng7m92	798	8	molecular	molecular	JJ
cord-262445-54ng7m92	798	9	mechanisms	mechanism	NNS
cord-262445-54ng7m92	798	10	at	at	IN
cord-262445-54ng7m92	798	11	the	the	DT
cord-262445-54ng7m92	798	12	basis	basis	NN
cord-262445-54ng7m92	798	13	of	of	IN
cord-262445-54ng7m92	798	14	muscular	muscular	JJ
cord-262445-54ng7m92	798	15	dystrophies	dystrophy	NNS
cord-262445-54ng7m92	798	16	.	.	.
cord-262445-54ng7m92	799	1	P.	P.	NNP
cord-262445-54ng7m92	799	2	25	25	CD
cord-262445-54ng7m92	799	3	.	.	.
cord-262445-54ng7m92	800	1	Effects	effect	NNS
cord-262445-54ng7m92	800	2	of	of	IN
cord-262445-54ng7m92	800	3	aerobic	aerobic	JJ
cord-262445-54ng7m92	800	4	,	,	,
cord-262445-54ng7m92	800	5	resistance	resistance	NN
cord-262445-54ng7m92	800	6	and	and	CC
cord-262445-54ng7m92	800	7	combined	combine	VBN
cord-262445-54ng7m92	800	8	exercises	exercise	NNS
cord-262445-54ng7m92	800	9	on	on	IN
cord-262445-54ng7m92	800	10	24-hr	24-hr	JJ
cord-262445-54ng7m92	800	11	glucose	glucose	NN
cord-262445-54ng7m92	800	12	variability	variability	NN
cord-262445-54ng7m92	800	13	,	,	,
cord-262445-54ng7m92	800	14	metabolism	metabolism	NN
cord-262445-54ng7m92	800	15	and	and	CC
cord-262445-54ng7m92	800	16	muscle	muscle	NN
cord-262445-54ng7m92	800	17	signalling	signal	VBG
cord-262445-54ng7m92	800	18	pathways	pathway	NNS
cord-262445-54ng7m92	800	19	regulation	regulation	NN
cord-262445-54ng7m92	800	20	in	in	IN
cord-262445-54ng7m92	800	21	Type	type	NN
cord-262445-54ng7m92	800	22	1	1	CD
cord-262445-54ng7m92	800	23	Diabetics	diabetic	NNS
cord-262445-54ng7m92	800	24	Giosuè	Giosuè	NNP
cord-262445-54ng7m92	800	25	Annibalini	Annibalini	NNP
cord-262445-54ng7m92	800	26	a	a	DT
cord-262445-54ng7m92	800	27	#	#	NN
cord-262445-54ng7m92	800	28	,	,	,
cord-262445-54ng7m92	800	29	Dean	Dean	NNP
cord-262445-54ng7m92	800	30	Minnock	Minnock	NNP
cord-262445-54ng7m92	800	31	b	b	NNP
cord-262445-54ng7m92	800	32	#	#	NN
cord-262445-54ng7m92	800	33	,	,	,
cord-262445-54ng7m92	800	34	Giacomo	Giacomo	NNP
cord-262445-54ng7m92	800	35	Valli	Valli	NNP
cord-262445-54ng7m92	800	36	a	a	NNP
cord-262445-54ng7m92	800	37	,	,	,
cord-262445-54ng7m92	800	38	Serena	Serena	NNP
cord-262445-54ng7m92	800	39	Contarelli	Contarelli	NNP
cord-262445-54ng7m92	801	1	a	a	LS
cord-262445-54ng7m92	801	2	,	,	,
cord-262445-54ng7m92	801	3	Roberta	Roberta	NNP
cord-262445-54ng7m92	801	4	Saltarelli	Saltarelli	NNP
cord-262445-54ng7m92	801	5	a	a	NNP
cord-262445-54ng7m92	801	6	,	,	,
cord-262445-54ng7m92	801	7	Carel	Carel	NNP
cord-262445-54ng7m92	801	8	Leroux	Leroux	NNP
cord-262445-54ng7m92	801	9	c	c	NNP
cord-262445-54ng7m92	801	10	,	,	,
cord-262445-54ng7m92	802	1	Vilberto	Vilberto	NNP
cord-262445-54ng7m92	802	2	Stocchi	Stocchi	NNP
cord-262445-54ng7m92	802	3	a	a	NNP
cord-262445-54ng7m92	802	4	,	,	,
cord-262445-54ng7m92	802	5	Elena	Elena	NNP
cord-262445-54ng7m92	802	6	Barbieri	Barbieri	NNP
cord-262445-54ng7m92	803	1	a	a	LS
cord-262445-54ng7m92	803	2	,	,	,
cord-262445-54ng7m92	803	3	d	d	NN
cord-262445-54ng7m92	803	4	,	,	,
cord-262445-54ng7m92	803	5	Giuseppe	Giuseppe	NNP
cord-262445-54ng7m92	803	6	De	De	NNP
cord-262445-54ng7m92	803	7	Vito	Vito	NNP
cord-262445-54ng7m92	803	8	b	b	NNP
cord-262445-54ng7m92	803	9	;	;	:
cord-262445-54ng7m92	803	10	#	#	NN
cord-262445-54ng7m92	803	11	Equally	equally	RB
cord-262445-54ng7m92	803	12	contributing	contribute	VBG
cord-262445-54ng7m92	803	13	authors	author	NNS
cord-262445-54ng7m92	803	14	Duchenne	Duchenne	NNP
cord-262445-54ng7m92	803	15	muscular	muscular	JJ
cord-262445-54ng7m92	803	16	dystrophy	dystrophy	NN
cord-262445-54ng7m92	803	17	(	(	-LRB-
cord-262445-54ng7m92	803	18	DMD	DMD	NNP
cord-262445-54ng7m92	803	19	)	)	-RRB-
cord-262445-54ng7m92	803	20	is	be	VBZ
cord-262445-54ng7m92	803	21	a	a	DT
cord-262445-54ng7m92	803	22	neuromuscular	neuromuscular	JJ
cord-262445-54ng7m92	803	23	disease	disease	NN
cord-262445-54ng7m92	803	24	caused	cause	VBN
cord-262445-54ng7m92	803	25	by	by	IN
cord-262445-54ng7m92	803	26	a	a	DT
cord-262445-54ng7m92	803	27	deficiency	deficiency	NN
cord-262445-54ng7m92	803	28	of	of	IN
cord-262445-54ng7m92	803	29	the	the	DT
cord-262445-54ng7m92	803	30	dystrophin	dystrophin	NN
cord-262445-54ng7m92	803	31	protein	protein	NN
cord-262445-54ng7m92	803	32	.	.	.
cord-262445-54ng7m92	804	1	Currently	currently	RB
cord-262445-54ng7m92	804	2	no	no	DT
cord-262445-54ng7m92	804	3	cure	cure	NN
cord-262445-54ng7m92	804	4	is	be	VBZ
cord-262445-54ng7m92	804	5	available	available	JJ
cord-262445-54ng7m92	804	6	for	for	IN
cord-262445-54ng7m92	804	7	the	the	DT
cord-262445-54ng7m92	804	8	disease	disease	NN
cord-262445-54ng7m92	804	9	and	and	CC
cord-262445-54ng7m92	804	10	numerous	numerous	JJ
cord-262445-54ng7m92	804	11	pharmacological	pharmacological	JJ
cord-262445-54ng7m92	804	12	approaches	approach	NNS
cord-262445-54ng7m92	804	13	are	be	VBP
cord-262445-54ng7m92	804	14	being	be	VBG
cord-262445-54ng7m92	804	15	studied	study	VBN
cord-262445-54ng7m92	804	16	to	to	TO
cord-262445-54ng7m92	804	17	extend	extend	VB
cord-262445-54ng7m92	804	18	the	the	DT
cord-262445-54ng7m92	804	19	regenerative	regenerative	JJ
cord-262445-54ng7m92	804	20	phase	phase	NN
cord-262445-54ng7m92	804	21	of	of	IN
cord-262445-54ng7m92	804	22	dystrophic	dystrophic	JJ
cord-262445-54ng7m92	804	23	muscles	muscle	NNS
cord-262445-54ng7m92	804	24	.	.	.
cord-262445-54ng7m92	805	1	In	in	IN
cord-262445-54ng7m92	805	2	this	this	DT
cord-262445-54ng7m92	805	3	project	project	NN
cord-262445-54ng7m92	805	4	we	-PRON-	PRP
cord-262445-54ng7m92	805	5	aim	aim	VBP
cord-262445-54ng7m92	805	6	to	to	TO
cord-262445-54ng7m92	805	7	investigate	investigate	VB
cord-262445-54ng7m92	805	8	if	if	IN
cord-262445-54ng7m92	805	9	the	the	DT
cord-262445-54ng7m92	805	10	modulation	modulation	NN
cord-262445-54ng7m92	805	11	of	of	IN
cord-262445-54ng7m92	805	12	the	the	DT
cord-262445-54ng7m92	805	13	epi	epi	NNP
cord-262445-54ng7m92	805	14	-	-	HYPH
cord-262445-54ng7m92	805	15	transcriptome	transcriptome	NNP
cord-262445-54ng7m92	805	16	could	could	MD
cord-262445-54ng7m92	805	17	represent	represent	VB
cord-262445-54ng7m92	805	18	a	a	DT
cord-262445-54ng7m92	805	19	new	new	JJ
cord-262445-54ng7m92	805	20	pharmacological	pharmacological	JJ
cord-262445-54ng7m92	805	21	tool	tool	NN
cord-262445-54ng7m92	805	22	for	for	IN
cord-262445-54ng7m92	805	23	DMD	DMD	NNP
cord-262445-54ng7m92	805	24	.	.	.
cord-262445-54ng7m92	806	1	In	in	IN
cord-262445-54ng7m92	806	2	recent	recent	JJ
cord-262445-54ng7m92	806	3	years	year	NNS
cord-262445-54ng7m92	806	4	,	,	,
cord-262445-54ng7m92	806	5	genetic	genetic	JJ
cord-262445-54ng7m92	806	6	and	and	CC
cord-262445-54ng7m92	806	7	biochemical	biochemical	JJ
cord-262445-54ng7m92	806	8	studies	study	NNS
cord-262445-54ng7m92	806	9	have	have	VBP
cord-262445-54ng7m92	806	10	revealed	reveal	VBN
cord-262445-54ng7m92	806	11	how	how	WRB
cord-262445-54ng7m92	806	12	post	post	JJ
cord-262445-54ng7m92	806	13	-	-	JJ
cord-262445-54ng7m92	806	14	transcriptional	transcriptional	JJ
cord-262445-54ng7m92	806	15	modifications	modification	NNS
cord-262445-54ng7m92	806	16	of	of	IN
cord-262445-54ng7m92	806	17	RNA	RNA	NNP
cord-262445-54ng7m92	806	18	influence	influence	NN
cord-262445-54ng7m92	806	19	various	various	JJ
cord-262445-54ng7m92	806	20	cellular	cellular	JJ
cord-262445-54ng7m92	806	21	mechanisms	mechanism	NNS
cord-262445-54ng7m92	806	22	,	,	,
cord-262445-54ng7m92	806	23	in	in	IN
cord-262445-54ng7m92	806	24	particular	particular	JJ
cord-262445-54ng7m92	806	25	splicing	splicing	NN
cord-262445-54ng7m92	806	26	,	,	,
cord-262445-54ng7m92	806	27	miRNA	miRNA	NNP
cord-262445-54ng7m92	806	28	processing	processing	NN
cord-262445-54ng7m92	806	29	and	and	CC
cord-262445-54ng7m92	806	30	transcripts	transcript	NNS
cord-262445-54ng7m92	806	31	stability	stability	NN
cord-262445-54ng7m92	806	32	.	.	.
cord-262445-54ng7m92	807	1	One	one	CD
cord-262445-54ng7m92	807	2	of	of	IN
cord-262445-54ng7m92	807	3	the	the	DT
cord-262445-54ng7m92	807	4	most	most	RBS
cord-262445-54ng7m92	807	5	important	important	JJ
cord-262445-54ng7m92	807	6	changes	change	NNS
cord-262445-54ng7m92	807	7	in	in	IN
cord-262445-54ng7m92	807	8	RNA	RNA	NNP
cord-262445-54ng7m92	807	9	is	be	VBZ
cord-262445-54ng7m92	807	10	N6-methyladenosine	N6-methyladenosine	.
cord-262445-54ng7m92	808	1	(	(	-LRB-
cord-262445-54ng7m92	808	2	m6A	m6A	NNP
cord-262445-54ng7m92	808	3	)	)	-RRB-
cord-262445-54ng7m92	808	4	.	.	.
cord-262445-54ng7m92	809	1	This	this	DT
cord-262445-54ng7m92	809	2	modification	modification	NN
cord-262445-54ng7m92	809	3	is	be	VBZ
cord-262445-54ng7m92	809	4	added	add	VBN
cord-262445-54ng7m92	809	5	from	from	IN
cord-262445-54ng7m92	809	6	a	a	DT
cord-262445-54ng7m92	809	7	complex	complex	NN
cord-262445-54ng7m92	809	8	containing	contain	VBG
cord-262445-54ng7m92	809	9	the	the	DT
cord-262445-54ng7m92	809	10	METTL3	METTL3	NNP
cord-262445-54ng7m92	809	11	/	/	SYM
cord-262445-54ng7m92	809	12	METTL14	METTL14	NNP
cord-262445-54ng7m92	809	13	heterodimer	heterodimer	NN
cord-262445-54ng7m92	809	14	and	and	CC
cord-262445-54ng7m92	809	15	removed	remove	VBN
cord-262445-54ng7m92	809	16	from	from	IN
cord-262445-54ng7m92	809	17	RNA	RNA	NNP
cord-262445-54ng7m92	809	18	demethylases	demethylase	NNS
cord-262445-54ng7m92	809	19	such	such	JJ
cord-262445-54ng7m92	809	20	as	as	IN
cord-262445-54ng7m92	809	21	FTO	FTO	NNP
cord-262445-54ng7m92	809	22	and	and	CC
cord-262445-54ng7m92	809	23	ALKBH5	alkbh5	NN
cord-262445-54ng7m92	809	24	.	.	.
cord-262445-54ng7m92	810	1	We	-PRON-	PRP
cord-262445-54ng7m92	810	2	have	have	VBP
cord-262445-54ng7m92	810	3	recently	recently	RB
cord-262445-54ng7m92	810	4	observed	observe	VBN
cord-262445-54ng7m92	810	5	an	an	DT
cord-262445-54ng7m92	810	6	increase	increase	NN
cord-262445-54ng7m92	810	7	in	in	IN
cord-262445-54ng7m92	810	8	m6A	m6a	NN
cord-262445-54ng7m92	810	9	levels	level	NNS
cord-262445-54ng7m92	810	10	in	in	IN
cord-262445-54ng7m92	810	11	skeletal	skeletal	JJ
cord-262445-54ng7m92	810	12	muscles	muscle	NNS
cord-262445-54ng7m92	810	13	derived	derive	VBN
cord-262445-54ng7m92	810	14	from	from	IN
cord-262445-54ng7m92	810	15	dystrophic	dystrophic	JJ
cord-262445-54ng7m92	810	16	mice	mouse	NNS
cord-262445-54ng7m92	810	17	compared	compare	VBN
cord-262445-54ng7m92	810	18	to	to	IN
cord-262445-54ng7m92	810	19	wilde	wilde	NNP
cord-262445-54ng7m92	810	20	type	type	NN
cord-262445-54ng7m92	810	21	animals	animal	NNS
cord-262445-54ng7m92	810	22	,	,	,
cord-262445-54ng7m92	810	23	suggesting	suggest	VBG
cord-262445-54ng7m92	810	24	that	that	IN
cord-262445-54ng7m92	810	25	under	under	IN
cord-262445-54ng7m92	810	26	pathological	pathological	JJ
cord-262445-54ng7m92	810	27	conditions	condition	NNS
cord-262445-54ng7m92	810	28	the	the	DT
cord-262445-54ng7m92	810	29	N6-Methyladenosine	N6-Methyladenosine	NNP
cord-262445-54ng7m92	810	30	modification	modification	NN
cord-262445-54ng7m92	810	31	could	could	MD
cord-262445-54ng7m92	810	32	influence	influence	VB
cord-262445-54ng7m92	810	33	muscle	muscle	NN
cord-262445-54ng7m92	810	34	regeneration	regeneration	NN
cord-262445-54ng7m92	810	35	through	through	IN
cord-262445-54ng7m92	810	36	the	the	DT
cord-262445-54ng7m92	810	37	modulation	modulation	NN
cord-262445-54ng7m92	810	38	of	of	IN
cord-262445-54ng7m92	810	39	various	various	JJ
cord-262445-54ng7m92	810	40	cellular	cellular	JJ
cord-262445-54ng7m92	810	41	pathways	pathway	NNS
cord-262445-54ng7m92	810	42	.	.	.
cord-262445-54ng7m92	811	1	To	to	TO
cord-262445-54ng7m92	811	2	validate	validate	VB
cord-262445-54ng7m92	811	3	this	this	DT
cord-262445-54ng7m92	811	4	hypothesis	hypothesis	NN
cord-262445-54ng7m92	811	5	,	,	,
cord-262445-54ng7m92	811	6	we	-PRON-	PRP
cord-262445-54ng7m92	811	7	conducted	conduct	VBD
cord-262445-54ng7m92	811	8	several	several	JJ
cord-262445-54ng7m92	811	9	experiments	experiment	NNS
cord-262445-54ng7m92	811	10	both	both	CC
cord-262445-54ng7m92	811	11	in	in	IN
cord-262445-54ng7m92	811	12	vivo	vivo	NNP
cord-262445-54ng7m92	811	13	and	and	CC
cord-262445-54ng7m92	811	14	ex	ex	NN
cord-262445-54ng7m92	811	15	vivo	vivo	NN
cord-262445-54ng7m92	811	16	using	use	VBG
cord-262445-54ng7m92	811	17	pharmacological	pharmacological	JJ
cord-262445-54ng7m92	811	18	and	and	CC
cord-262445-54ng7m92	811	19	genetic	genetic	JJ
cord-262445-54ng7m92	811	20	approaches	approach	NNS
cord-262445-54ng7m92	811	21	,	,	,
cord-262445-54ng7m92	811	22	aimed	aim	VBN
cord-262445-54ng7m92	811	23	at	at	IN
cord-262445-54ng7m92	811	24	modulating	modulate	VBG
cord-262445-54ng7m92	811	25	the	the	DT
cord-262445-54ng7m92	811	26	expression	expression	NN
cord-262445-54ng7m92	811	27	and	and	CC
cord-262445-54ng7m92	811	28	activity	activity	NN
cord-262445-54ng7m92	811	29	of	of	IN
cord-262445-54ng7m92	811	30	components	component	NNS
cord-262445-54ng7m92	811	31	of	of	IN
cord-262445-54ng7m92	811	32	the	the	DT
cord-262445-54ng7m92	811	33	methylation	methylation	NN
cord-262445-54ng7m92	811	34	machinery	machinery	NN
cord-262445-54ng7m92	811	35	.	.	.
cord-262445-54ng7m92	812	1	In	in	IN
cord-262445-54ng7m92	812	2	the	the	DT
cord-262445-54ng7m92	812	3	pharmacological	pharmacological	JJ
cord-262445-54ng7m92	812	4	approach	approach	NN
cord-262445-54ng7m92	812	5	we	-PRON-	PRP
cord-262445-54ng7m92	812	6	have	have	VBP
cord-262445-54ng7m92	812	7	treated	treat	VBN
cord-262445-54ng7m92	812	8	dystrophic	dystrophic	JJ
cord-262445-54ng7m92	812	9	mice	mouse	NNS
cord-262445-54ng7m92	812	10	with	with	IN
cord-262445-54ng7m92	812	11	a	a	DT
cord-262445-54ng7m92	812	12	drug	drug	NN
cord-262445-54ng7m92	812	13	approved	approve	VBN
cord-262445-54ng7m92	812	14	by	by	IN
cord-262445-54ng7m92	812	15	the	the	DT
cord-262445-54ng7m92	812	16	FDA	FDA	NNP
cord-262445-54ng7m92	812	17	that	that	WDT
cord-262445-54ng7m92	812	18	has	have	VBZ
cord-262445-54ng7m92	812	19	recently	recently	RB
cord-262445-54ng7m92	812	20	shown	show	VBN
cord-262445-54ng7m92	812	21	to	to	TO
cord-262445-54ng7m92	812	22	increase	increase	VB
cord-262445-54ng7m92	812	23	RNA	RNA	NNP
cord-262445-54ng7m92	812	24	methylation	methylation	NN
cord-262445-54ng7m92	812	25	through	through	IN
cord-262445-54ng7m92	812	26	the	the	DT
cord-262445-54ng7m92	812	27	inhibition	inhibition	NN
cord-262445-54ng7m92	812	28	of	of	IN
cord-262445-54ng7m92	812	29	FTO	FTO	NNP
cord-262445-54ng7m92	812	30	demethylase	demethylase	NNP
cord-262445-54ng7m92	812	31	;	;	:
cord-262445-54ng7m92	812	32	the	the	DT
cord-262445-54ng7m92	812	33	genetic	genetic	JJ
cord-262445-54ng7m92	812	34	approach	approach	NN
cord-262445-54ng7m92	812	35	instead	instead	RB
cord-262445-54ng7m92	812	36	involves	involve	VBZ
cord-262445-54ng7m92	812	37	the	the	DT
cord-262445-54ng7m92	812	38	use	use	NN
cord-262445-54ng7m92	812	39	of	of	IN
cord-262445-54ng7m92	812	40	siRNA	siRNA	NNP
cord-262445-54ng7m92	812	41	against	against	IN
cord-262445-54ng7m92	812	42	Metll3	Metll3	NNP
cord-262445-54ng7m92	812	43	in	in	IN
cord-262445-54ng7m92	812	44	primary	primary	JJ
cord-262445-54ng7m92	812	45	myoblasts	myoblast	NNS
cord-262445-54ng7m92	812	46	.	.	.
cord-262445-54ng7m92	813	1	Our	-PRON-	PRP$
cord-262445-54ng7m92	813	2	preliminary	preliminary	JJ
cord-262445-54ng7m92	813	3	results	result	NNS
cord-262445-54ng7m92	813	4	showed	show	VBD
cord-262445-54ng7m92	813	5	that	that	IN
cord-262445-54ng7m92	813	6	the	the	DT
cord-262445-54ng7m92	813	7	RNA	RNA	NNP
cord-262445-54ng7m92	813	8	methylome	methylome	NNP
cord-262445-54ng7m92	813	9	(	(	-LRB-
cord-262445-54ng7m92	813	10	m6A	m6A	NNP
cord-262445-54ng7m92	813	11	)	)	-RRB-
cord-262445-54ng7m92	813	12	is	be	VBZ
cord-262445-54ng7m92	813	13	dynamically	dynamically	RB
cord-262445-54ng7m92	813	14	modulated	modulate	VBN
cord-262445-54ng7m92	813	15	during	during	IN
cord-262445-54ng7m92	813	16	skeletal	skeletal	JJ
cord-262445-54ng7m92	813	17	muscle	muscle	NN
cord-262445-54ng7m92	813	18	differentiation	differentiation	NN
cord-262445-54ng7m92	813	19	and	and	CC
cord-262445-54ng7m92	813	20	regeneration	regeneration	NN
cord-262445-54ng7m92	813	21	,	,	,
cord-262445-54ng7m92	813	22	pointing	point	VBG
cord-262445-54ng7m92	813	23	at	at	IN
cord-262445-54ng7m92	813	24	the	the	DT
cord-262445-54ng7m92	813	25	epi	epi	NNP
cord-262445-54ng7m92	813	26	-	-	HYPH
cord-262445-54ng7m92	813	27	transcriptome	transcriptome	NNP
cord-262445-54ng7m92	813	28	as	as	IN
cord-262445-54ng7m92	813	29	a	a	DT
cord-262445-54ng7m92	813	30	new	new	JJ
cord-262445-54ng7m92	813	31	potential	potential	JJ
cord-262445-54ng7m92	813	32	target	target	NN
cord-262445-54ng7m92	813	33	for	for	IN
cord-262445-54ng7m92	813	34	therapeutic	therapeutic	JJ
cord-262445-54ng7m92	813	35	interventions	intervention	NNS
cord-262445-54ng7m92	813	36	.	.	.
cord-262445-54ng7m92	814	1	In	in	IN
cord-262445-54ng7m92	814	2	addition	addition	NN
cord-262445-54ng7m92	814	3	,	,	,
cord-262445-54ng7m92	814	4	we	-PRON-	PRP
cord-262445-54ng7m92	814	5	identified	identify	VBD
cord-262445-54ng7m92	814	6	new	new	JJ
cord-262445-54ng7m92	814	7	METTL3	METTL3	NNP
cord-262445-54ng7m92	814	8	direct	direct	JJ
cord-262445-54ng7m92	814	9	targets	target	NNS
cord-262445-54ng7m92	814	10	in	in	IN
cord-262445-54ng7m92	814	11	muscle	muscle	NN
cord-262445-54ng7m92	814	12	cells	cell	NNS
cord-262445-54ng7m92	814	13	through	through	IN
cord-262445-54ng7m92	814	14	RNA	RNA	NNP
cord-262445-54ng7m92	814	15	-	-	HYPH
cord-262445-54ng7m92	814	16	seq	seq	NN
cord-262445-54ng7m92	814	17	experiments	experiment	NNS
cord-262445-54ng7m92	814	18	.	.	.
cord-262445-54ng7m92	815	1	Finally	finally	RB
cord-262445-54ng7m92	815	2	,	,	,
cord-262445-54ng7m92	815	3	increasing	increase	VBG
cord-262445-54ng7m92	815	4	RNA	RNA	NNP
cord-262445-54ng7m92	815	5	methylation	methylation	NN
cord-262445-54ng7m92	815	6	by	by	IN
cord-262445-54ng7m92	815	7	FTO	FTO	NNP
cord-262445-54ng7m92	815	8	inhibition	inhibition	NN
cord-262445-54ng7m92	815	9	modulates	modulate	VBZ
cord-262445-54ng7m92	815	10	the	the	DT
cord-262445-54ng7m92	815	11	regenerative	regenerative	JJ
cord-262445-54ng7m92	815	12	response	response	NN
cord-262445-54ng7m92	815	13	in	in	IN
cord-262445-54ng7m92	815	14	dystrophic	dystrophic	NNP
cord-262445-54ng7m92	815	15	mice	mouse	NNS
cord-262445-54ng7m92	815	16	.	.	.
cord-262445-54ng7m92	816	1	Altogether	altogether	RB
cord-262445-54ng7m92	816	2	,	,	,
cord-262445-54ng7m92	816	3	the	the	DT
cord-262445-54ng7m92	816	4	results	result	NNS
cord-262445-54ng7m92	816	5	derived	derive	VBN
cord-262445-54ng7m92	816	6	from	from	IN
cord-262445-54ng7m92	816	7	these	these	DT
cord-262445-54ng7m92	816	8	studies	study	NNS
cord-262445-54ng7m92	816	9	will	will	MD
cord-262445-54ng7m92	816	10	set	set	VB
cord-262445-54ng7m92	816	11	up	up	RP
cord-262445-54ng7m92	816	12	the	the	DT
cord-262445-54ng7m92	816	13	basis	basis	NN
cord-262445-54ng7m92	816	14	for	for	IN
cord-262445-54ng7m92	816	15	a	a	DT
cord-262445-54ng7m92	816	16	new	new	JJ
cord-262445-54ng7m92	816	17	therapy	therapy	NN
cord-262445-54ng7m92	816	18	based	base	VBN
cord-262445-54ng7m92	816	19	on	on	IN
cord-262445-54ng7m92	816	20	the	the	DT
cord-262445-54ng7m92	816	21	modulation	modulation	NN
cord-262445-54ng7m92	816	22	of	of	IN
cord-262445-54ng7m92	816	23	the	the	DT
cord-262445-54ng7m92	816	24	epi	epi	NN
cord-262445-54ng7m92	816	25	-	-	HYPH
cord-262445-54ng7m92	816	26	transcriptome	transcriptome	NN
cord-262445-54ng7m92	816	27	for	for	IN
cord-262445-54ng7m92	816	28	DMD	DMD	NNP
cord-262445-54ng7m92	816	29	.	.	.
cord-262445-54ng7m92	817	1	Italy	Italy	NNP
cord-262445-54ng7m92	817	2	Muscular	muscular	JJ
cord-262445-54ng7m92	817	3	dystrophies	dystrophy	NNS
cord-262445-54ng7m92	817	4	are	be	VBP
cord-262445-54ng7m92	817	5	a	a	DT
cord-262445-54ng7m92	817	6	group	group	NN
cord-262445-54ng7m92	817	7	of	of	IN
cord-262445-54ng7m92	817	8	heterogenous	heterogenous	JJ
cord-262445-54ng7m92	817	9	genetic	genetic	JJ
cord-262445-54ng7m92	817	10	neuromuscular	neuromuscular	JJ
cord-262445-54ng7m92	817	11	pathologies	pathology	NNS
cord-262445-54ng7m92	817	12	,	,	,
cord-262445-54ng7m92	817	13	usually	usually	RB
cord-262445-54ng7m92	817	14	manifesting	manifest	VBG
cord-262445-54ng7m92	817	15	a	a	DT
cord-262445-54ng7m92	817	16	progressive	progressive	JJ
cord-262445-54ng7m92	817	17	muscle	muscle	NN
cord-262445-54ng7m92	817	18	degeneration	degeneration	NN
cord-262445-54ng7m92	817	19	accompanied	accompany	VBN
cord-262445-54ng7m92	817	20	by	by	IN
cord-262445-54ng7m92	817	21	strength	strength	NN
cord-262445-54ng7m92	817	22	detriment	detriment	NN
cord-262445-54ng7m92	817	23	.	.	.
cord-262445-54ng7m92	818	1	Despite	despite	IN
cord-262445-54ng7m92	818	2	muscular	muscular	JJ
cord-262445-54ng7m92	818	3	dystrophies	dystrophy	NNS
cord-262445-54ng7m92	818	4	are	be	VBP
cord-262445-54ng7m92	818	5	present	present	JJ
cord-262445-54ng7m92	818	6	in	in	IN
cord-262445-54ng7m92	818	7	more	more	JJR
cord-262445-54ng7m92	818	8	than	than	IN
cord-262445-54ng7m92	818	9	40	40	CD
cord-262445-54ng7m92	818	10	forms	form	NNS
cord-262445-54ng7m92	818	11	,	,	,
cord-262445-54ng7m92	818	12	many	many	JJ
cord-262445-54ng7m92	818	13	of	of	IN
cord-262445-54ng7m92	818	14	these	these	DT
cord-262445-54ng7m92	818	15	affect	affect	VBP
cord-262445-54ng7m92	819	1	the	the	DT
cord-262445-54ng7m92	819	2	Dystrophin	Dystrophin	NNP
cord-262445-54ng7m92	819	3	Associated	Associated	NNP
cord-262445-54ng7m92	819	4	Glycoprotein	Glycoprotein	NNP
cord-262445-54ng7m92	819	5	Complex	Complex	NNP
cord-262445-54ng7m92	819	6	(	(	-LRB-
cord-262445-54ng7m92	819	7	DAGC	DAGC	NNP
cord-262445-54ng7m92	819	8	)	)	-RRB-
cord-262445-54ng7m92	819	9	being	be	VBG
cord-262445-54ng7m92	819	10	responsible	responsible	JJ
cord-262445-54ng7m92	819	11	for	for	IN
cord-262445-54ng7m92	819	12	phenotype	phenotype	NN
cord-262445-54ng7m92	819	13	affection	affection	NN
cord-262445-54ng7m92	819	14	.	.	.
cord-262445-54ng7m92	820	1	Concretely	concretely	RB
cord-262445-54ng7m92	820	2	,	,	,
cord-262445-54ng7m92	820	3	the	the	DT
cord-262445-54ng7m92	820	4	involvement	involvement	NN
cord-262445-54ng7m92	820	5	of	of	IN
cord-262445-54ng7m92	820	6	Sarcoglycan	sarcoglycan	JJ
cord-262445-54ng7m92	820	7	(	(	-LRB-
cord-262445-54ng7m92	820	8	SG	SG	NNP
cord-262445-54ng7m92	820	9	)	)	-RRB-
cord-262445-54ng7m92	820	10	Complex	Complex	NNP
cord-262445-54ng7m92	820	11	,	,	,
cord-262445-54ng7m92	820	12	Dystrophin	Dystrophin	NNP
cord-262445-54ng7m92	820	13	,	,	,
cord-262445-54ng7m92	820	14	or	or	CC
cord-262445-54ng7m92	820	15	α	α	NN
cord-262445-54ng7m92	820	16	-	-	HYPH
cord-262445-54ng7m92	820	17	Dystroglycan	Dystroglycan	NNP
cord-262445-54ng7m92	820	18	,	,	,
cord-262445-54ng7m92	820	19	present	present	VBP
cord-262445-54ng7m92	820	20	a	a	DT
cord-262445-54ng7m92	820	21	relative	relative	JJ
cord-262445-54ng7m92	820	22	common	common	JJ
cord-262445-54ng7m92	820	23	clinical	clinical	JJ
cord-262445-54ng7m92	820	24	manifestation	manifestation	NN
cord-262445-54ng7m92	820	25	affecting	affect	VBG
cord-262445-54ng7m92	820	26	proximal	proximal	JJ
cord-262445-54ng7m92	820	27	muscles	muscle	NNS
cord-262445-54ng7m92	820	28	differing	differ	VBG
cord-262445-54ng7m92	820	29	on	on	IN
cord-262445-54ng7m92	820	30	pathological	pathological	JJ
cord-262445-54ng7m92	820	31	severity	severity	NN
cord-262445-54ng7m92	820	32	.	.	.
cord-262445-54ng7m92	821	1	Nowadays	nowadays	RB
cord-262445-54ng7m92	821	2	,	,	,
cord-262445-54ng7m92	821	3	no	no	DT
cord-262445-54ng7m92	821	4	cure	cure	NN
cord-262445-54ng7m92	821	5	is	be	VBZ
cord-262445-54ng7m92	821	6	available	available	JJ
cord-262445-54ng7m92	821	7	for	for	IN
cord-262445-54ng7m92	821	8	these	these	DT
cord-262445-54ng7m92	821	9	disease	disease	NN
cord-262445-54ng7m92	821	10	,	,	,
cord-262445-54ng7m92	821	11	however	however	RB
cord-262445-54ng7m92	821	12	different	different	JJ
cord-262445-54ng7m92	821	13	strategies	strategy	NNS
cord-262445-54ng7m92	821	14	are	be	VBP
cord-262445-54ng7m92	821	15	emerging	emerge	VBG
cord-262445-54ng7m92	821	16	against	against	IN
cord-262445-54ng7m92	821	17	muscle	muscle	NN
cord-262445-54ng7m92	821	18	degeneration	degeneration	NN
cord-262445-54ng7m92	821	19	likewise	likewise	RB
cord-262445-54ng7m92	821	20	gene	gene	NN
cord-262445-54ng7m92	821	21	and	and	CC
cord-262445-54ng7m92	821	22	cell	cell	NN
cord-262445-54ng7m92	821	23	therapy	therapy	NN
cord-262445-54ng7m92	821	24	,	,	,
cord-262445-54ng7m92	821	25	or	or	CC
cord-262445-54ng7m92	821	26	anti	anti	JJ
cord-262445-54ng7m92	821	27	-	-	JJ
cord-262445-54ng7m92	821	28	inflammatory	inflammatory	JJ
cord-262445-54ng7m92	821	29	treatments	treatment	NNS
cord-262445-54ng7m92	821	30	.	.	.
cord-262445-54ng7m92	822	1	These	these	DT
cord-262445-54ng7m92	822	2	strategies	strategy	NNS
cord-262445-54ng7m92	822	3	aim	aim	VBP
cord-262445-54ng7m92	822	4	to	to	TO
cord-262445-54ng7m92	822	5	reestablish	reestablish	VB
cord-262445-54ng7m92	822	6	the	the	DT
cord-262445-54ng7m92	822	7	genetic	genetic	JJ
cord-262445-54ng7m92	822	8	disorders	disorder	NNS
cord-262445-54ng7m92	822	9	and	and	CC
cord-262445-54ng7m92	822	10	muscle	muscle	NN
cord-262445-54ng7m92	822	11	integrity	integrity	NN
cord-262445-54ng7m92	822	12	,	,	,
cord-262445-54ng7m92	822	13	or	or	CC
cord-262445-54ng7m92	822	14	at	at	IN
cord-262445-54ng7m92	822	15	least	least	JJS
cord-262445-54ng7m92	822	16	to	to	TO
cord-262445-54ng7m92	822	17	reduce	reduce	VB
cord-262445-54ng7m92	822	18	fibrosis	fibrosis	NN
cord-262445-54ng7m92	822	19	and	and	CC
cord-262445-54ng7m92	822	20	stop	stop	VB
cord-262445-54ng7m92	822	21	fat	fat	JJ
cord-262445-54ng7m92	822	22	replacement	replacement	NN
cord-262445-54ng7m92	822	23	.	.	.
cord-262445-54ng7m92	823	1	Nevertheless	nevertheless	RB
cord-262445-54ng7m92	823	2	,	,	,
cord-262445-54ng7m92	823	3	spontaneously	spontaneously	RB
cord-262445-54ng7m92	823	4	several	several	JJ
cord-262445-54ng7m92	823	5	muscle	muscle	NN
cord-262445-54ng7m92	823	6	groups	group	NNS
cord-262445-54ng7m92	823	7	resist	resist	VBP
cord-262445-54ng7m92	823	8	degeneration	degeneration	NN
cord-262445-54ng7m92	823	9	and	and	CC
cord-262445-54ng7m92	823	10	wasting	wasting	NN
cord-262445-54ng7m92	823	11	process	process	NN
cord-262445-54ng7m92	823	12	as	as	IN
cord-262445-54ng7m92	823	13	it	-PRON-	PRP
cord-262445-54ng7m92	823	14	occurs	occur	VBZ
cord-262445-54ng7m92	823	15	with	with	IN
cord-262445-54ng7m92	823	16	tongue	tongue	NN
cord-262445-54ng7m92	823	17	and	and	CC
cord-262445-54ng7m92	823	18	calf	calf	NN
cord-262445-54ng7m92	823	19	in	in	IN
cord-262445-54ng7m92	823	20	human	human	JJ
cord-262445-54ng7m92	823	21	patients	patient	NNS
cord-262445-54ng7m92	823	22	.	.	.
cord-262445-54ng7m92	824	1	We	-PRON-	PRP
cord-262445-54ng7m92	824	2	analyzed	analyze	VBD
cord-262445-54ng7m92	824	3	mdx	mdx	NNP
cord-262445-54ng7m92	824	4	and	and	CC
cord-262445-54ng7m92	824	5	α	α	NN
cord-262445-54ng7m92	824	6	-	-	HYPH
cord-262445-54ng7m92	824	7	sarcoglycan	sarcoglycan	JJ
cord-262445-54ng7m92	824	8	mouse	mouse	NN
cord-262445-54ng7m92	824	9	model	model	NN
cord-262445-54ng7m92	824	10	revealing	reveal	VBG
cord-262445-54ng7m92	824	11	differences	difference	NNS
cord-262445-54ng7m92	824	12	on	on	IN
cord-262445-54ng7m92	824	13	myofibers	myofiber	NNS
cord-262445-54ng7m92	824	14	degeneration	degeneration	NN
cord-262445-54ng7m92	824	15	among	among	IN
cord-262445-54ng7m92	824	16	muscle	muscle	NN
cord-262445-54ng7m92	824	17	groups	group	NNS
cord-262445-54ng7m92	824	18	of	of	IN
cord-262445-54ng7m92	824	19	the	the	DT
cord-262445-54ng7m92	824	20	same	same	JJ
cord-262445-54ng7m92	824	21	subject	subject	NN
cord-262445-54ng7m92	824	22	,	,	,
cord-262445-54ng7m92	824	23	presenting	present	VBG
cord-262445-54ng7m92	824	24	common	common	JJ
cord-262445-54ng7m92	824	25	affection	affection	NN
cord-262445-54ng7m92	824	26	frequency	frequency	NN
cord-262445-54ng7m92	824	27	.	.	.
cord-262445-54ng7m92	825	1	Our	-PRON-	PRP$
cord-262445-54ng7m92	825	2	objective	objective	NN
cord-262445-54ng7m92	825	3	is	be	VBZ
cord-262445-54ng7m92	825	4	to	to	TO
cord-262445-54ng7m92	825	5	go	go	VB
cord-262445-54ng7m92	825	6	deeper	deeply	RBR
cord-262445-54ng7m92	825	7	on	on	IN
cord-262445-54ng7m92	825	8	characterization	characterization	NN
cord-262445-54ng7m92	825	9	of	of	IN
cord-262445-54ng7m92	825	10	these	these	DT
cord-262445-54ng7m92	825	11	mice	mice	NN
cord-262445-54ng7m92	825	12	models	model	NNS
cord-262445-54ng7m92	825	13	Epigenetic	epigenetic	JJ
cord-262445-54ng7m92	825	14	tuning	tuning	NN
cord-262445-54ng7m92	825	15	of	of	IN
cord-262445-54ng7m92	825	16	miR	mir	NN
cord-262445-54ng7m92	825	17	in	in	IN
cord-262445-54ng7m92	825	18	FAP	fap	NN
cord-262445-54ng7m92	825	19	-	-	HYPH
cord-262445-54ng7m92	825	20	derived	derive	VBN
cord-262445-54ng7m92	825	21	Extracellular	Extracellular	NNP
cord-262445-54ng7m92	825	22	Vesicles	Vesicles	NNP
cord-262445-54ng7m92	825	23	promotes	promote	VBZ
cord-262445-54ng7m92	825	24	regeneration	regeneration	NN
cord-262445-54ng7m92	825	25	and	and	CC
cord-262445-54ng7m92	825	26	inhibits	inhibit	VBZ
cord-262445-54ng7m92	825	27	fibrosis	fibrosis	NN
cord-262445-54ng7m92	825	28	in	in	IN
cord-262445-54ng7m92	825	29	dystrophic	dystrophic	JJ
cord-262445-54ng7m92	825	30	muscles	muscle	VBZ
cord-262445-54ng7m92	825	31	Clinical	clinical	JJ
cord-262445-54ng7m92	825	32	R&D	R&D	NNP
cord-262445-54ng7m92	825	33	Italfarmaco	Italfarmaco	NNP
cord-262445-54ng7m92	825	34	SpA	spa	NN
cord-262445-54ng7m92	825	35	,	,	,
cord-262445-54ng7m92	825	36	Cinisello	Cinisello	NNP
cord-262445-54ng7m92	825	37	Balsamo	Balsamo	NNP
cord-262445-54ng7m92	825	38	.	.	.
cord-262445-54ng7m92	826	1	-50	-50	NN
cord-262445-54ng7m92	826	2	-60	-60	NNS
cord-262445-54ng7m92	826	3	,	,	,
cord-262445-54ng7m92	826	4	and	and	CC
cord-262445-54ng7m92	826	5	mainly	mainly	RB
cord-262445-54ng7m92	826	6	extracts	extract	VBZ
cord-262445-54ng7m92	826	7	proteins	protein	NNS
cord-262445-54ng7m92	826	8	from	from	IN
cord-262445-54ng7m92	826	9	multimeric	multimeric	JJ
cord-262445-54ng7m92	826	10	structures	structure	NNS
cord-262445-54ng7m92	826	11	.	.	.
cord-262445-54ng7m92	827	1	In	in	IN
cord-262445-54ng7m92	827	2	particular	particular	JJ
cord-262445-54ng7m92	827	3	,	,	,
cord-262445-54ng7m92	827	4	by	by	IN
cord-262445-54ng7m92	827	5	interacting	interact	VBG
cord-262445-54ng7m92	827	6	with	with	IN
cord-262445-54ng7m92	827	7	Ufd1	Ufd1	NNP
cord-262445-54ng7m92	827	8	or	or	CC
cord-262445-54ng7m92	827	9	p47	p47	CD
cord-262445-54ng7m92	827	10	,	,	,
cord-262445-54ng7m92	827	11	it	-PRON-	PRP
cord-262445-54ng7m92	827	12	facilitates	facilitate	VBZ
cord-262445-54ng7m92	827	13	the	the	DT
cord-262445-54ng7m92	827	14	rapid	rapid	JJ
cord-262445-54ng7m92	827	15	degradation	degradation	NN
cord-262445-54ng7m92	827	16	of	of	IN
cord-262445-54ng7m92	827	17	myofibrillar	myofibrillar	JJ
cord-262445-54ng7m92	827	18	proteins	protein	NNS
cord-262445-54ng7m92	827	19	during	during	IN
cord-262445-54ng7m92	827	20	muscle	muscle	NN
cord-262445-54ng7m92	827	21	atrophy	atrophy	NN
cord-262445-54ng7m92	827	22	caused	cause	VBN
cord-262445-54ng7m92	827	23	by	by	IN
cord-262445-54ng7m92	827	24	denervation	denervation	NN
cord-262445-54ng7m92	827	25	or	or	CC
cord-262445-54ng7m92	827	26	fasting	fasting	NN
cord-262445-54ng7m92	827	27	.	.	.
cord-262445-54ng7m92	828	1	The	the	DT
cord-262445-54ng7m92	828	2	aim	aim	NN
cord-262445-54ng7m92	828	3	of	of	IN
cord-262445-54ng7m92	828	4	this	this	DT
cord-262445-54ng7m92	828	5	study	study	NN
cord-262445-54ng7m92	828	6	was	be	VBD
cord-262445-54ng7m92	828	7	to	to	TO
cord-262445-54ng7m92	828	8	investigate	investigate	VB
cord-262445-54ng7m92	828	9	if	if	IN
cord-262445-54ng7m92	828	10	p97	p97	CD
cord-262445-54ng7m92	828	11	(	(	-LRB-
cord-262445-54ng7m92	828	12	and	and	CC
cord-262445-54ng7m92	828	13	through	through	IN
cord-262445-54ng7m92	828	14	which	which	WDT
cord-262445-54ng7m92	828	15	of	of	IN
cord-262445-54ng7m92	828	16	its	-PRON-	PRP$
cord-262445-54ng7m92	828	17	adaptors	adaptor	NNS
cord-262445-54ng7m92	828	18	)	)	-RRB-
cord-262445-54ng7m92	828	19	plays	play	VBZ
cord-262445-54ng7m92	828	20	a	a	DT
cord-262445-54ng7m92	828	21	role	role	NN
cord-262445-54ng7m92	828	22	also	also	RB
cord-262445-54ng7m92	828	23	during	during	IN
cord-262445-54ng7m92	828	24	cancer	cancer	NN
cord-262445-54ng7m92	828	25	cachexia	cachexia	NN
cord-262445-54ng7m92	828	26	and	and	CC
cord-262445-54ng7m92	828	27	if	if	IN
cord-262445-54ng7m92	828	28	this	this	DT
cord-262445-54ng7m92	828	29	is	be	VBZ
cord-262445-54ng7m92	828	30	modulated	modulate	VBN
cord-262445-54ng7m92	828	31	by	by	IN
cord-262445-54ng7m92	828	32	physical	physical	JJ
cord-262445-54ng7m92	828	33	exercise	exercise	NN
cord-262445-54ng7m92	828	34	.	.	.
cord-262445-54ng7m92	829	1	To	to	TO
cord-262445-54ng7m92	829	2	induce	induce	VB
cord-262445-54ng7m92	829	3	cachexia	cachexia	NN
cord-262445-54ng7m92	829	4	,	,	,
cord-262445-54ng7m92	829	5	we	-PRON-	PRP
cord-262445-54ng7m92	829	6	injected	inject	VBD
cord-262445-54ng7m92	829	7	subcutaneously	subcutaneously	RB
cord-262445-54ng7m92	829	8	one	one	CD
cord-262445-54ng7m92	829	9	million	million	CD
cord-262445-54ng7m92	829	10	of	of	IN
cord-262445-54ng7m92	829	11	colon	colon	NN
cord-262445-54ng7m92	829	12	adenocarcinoma	adenocarcinoma	NN
cord-262445-54ng7m92	829	13	(	(	-LRB-
cord-262445-54ng7m92	829	14	C26	C26	NNP
cord-262445-54ng7m92	829	15	)	)	-RRB-
cord-262445-54ng7m92	829	16	cells	cell	NNS
cord-262445-54ng7m92	829	17	in	in	IN
cord-262445-54ng7m92	829	18	BALB	BALB	NNP
cord-262445-54ng7m92	829	19	/	/	SYM
cord-262445-54ng7m92	829	20	c	c	NN
cord-262445-54ng7m92	829	21	mice	mouse	NNS
cord-262445-54ng7m92	829	22	.	.	.
cord-262445-54ng7m92	830	1	This	this	DT
cord-262445-54ng7m92	830	2	tumour	tumour	NN
cord-262445-54ng7m92	830	3	causes	cause	VBZ
cord-262445-54ng7m92	830	4	massive	massive	JJ
cord-262445-54ng7m92	830	5	muscle	muscle	NN
cord-262445-54ng7m92	830	6	depletion	depletion	NN
cord-262445-54ng7m92	830	7	with	with	IN
cord-262445-54ng7m92	830	8	premature	premature	JJ
cord-262445-54ng7m92	830	9	death	death	NN
cord-262445-54ng7m92	830	10	in	in	IN
cord-262445-54ng7m92	830	11	mice	mouse	NNS
cord-262445-54ng7m92	830	12	.	.	.
cord-262445-54ng7m92	831	1	Interestingly	interestingly	RB
cord-262445-54ng7m92	831	2	,	,	,
cord-262445-54ng7m92	831	3	by	by	IN
cord-262445-54ng7m92	831	4	microarrays	microarray	NNS
cord-262445-54ng7m92	831	5	,	,	,
cord-262445-54ng7m92	831	6	we	-PRON-	PRP
cord-262445-54ng7m92	831	7	found	find	VBD
cord-262445-54ng7m92	831	8	that	that	IN
cord-262445-54ng7m92	831	9	8	8	CD
cord-262445-54ng7m92	831	10	out	out	IN
cord-262445-54ng7m92	831	11	of	of	IN
cord-262445-54ng7m92	831	12	58	58	CD
cord-262445-54ng7m92	831	13	p97-binding	p97-binding	NN
cord-262445-54ng7m92	831	14	proteins	protein	NNS
cord-262445-54ng7m92	831	15	were	be	VBD
cord-262445-54ng7m92	831	16	induced	induce	VBN
cord-262445-54ng7m92	831	17	in	in	IN
cord-262445-54ng7m92	831	18	cachectic	cachectic	NNP
cord-262445-54ng7m92	831	19	Tibialis	Tibialis	NNP
cord-262445-54ng7m92	831	20	Anterior	Anterior	NNP
cord-262445-54ng7m92	831	21	(	(	-LRB-
cord-262445-54ng7m92	831	22	TA	TA	NNP
cord-262445-54ng7m92	831	23	)	)	-RRB-
cord-262445-54ng7m92	831	24	from	from	IN
cord-262445-54ng7m92	831	25	C26	C26	NNP
cord-262445-54ng7m92	831	26	mice	mouse	NNS
cord-262445-54ng7m92	831	27	24	24	CD
cord-262445-54ng7m92	832	1	The	the	DT
cord-262445-54ng7m92	832	2	RNA	RNA	NNP
cord-262445-54ng7m92	832	3	binding	bind	VBG
cord-262445-54ng7m92	832	4	protein	protein	NN
cord-262445-54ng7m92	832	5	FRG1	FRG1	NNP
cord-262445-54ng7m92	832	6	controls	control	NNS
cord-262445-54ng7m92	832	7	transcription	transcription	NN
cord-262445-54ng7m92	832	8	landscape	landscape	NN
cord-262445-54ng7m92	832	9	regulating	regulating	NN
cord-262445-54ng7m92	832	10	muscle	muscle	NN
cord-262445-54ng7m92	832	11	maturation	maturation	NN
cord-262445-54ng7m92	832	12	and	and	CC
cord-262445-54ng7m92	832	13	metabolism	metabolism	NN
cord-262445-54ng7m92	832	14	Mattia	Mattia	NNP
cord-262445-54ng7m92	832	15	Forcato	Forcato	NNP
cord-262445-54ng7m92	833	1	a	a	LS
cord-262445-54ng7m92	833	2	,	,	,
cord-262445-54ng7m92	833	3	Ernesto	Ernesto	NNP
cord-262445-54ng7m92	833	4	Picardi	Picardi	NNP
cord-262445-54ng7m92	833	5	b	b	NNP
cord-262445-54ng7m92	833	6	,	,	,
cord-262445-54ng7m92	833	7	Elena	Elena	NNP
cord-262445-54ng7m92	833	8	Germinario	Germinario	NNP
cord-262445-54ng7m92	833	9	c	c	NN
cord-262445-54ng7m92	833	10	,	,	,
cord-262445-54ng7m92	833	11	Bert	Bert	NNP
cord-262445-54ng7m92	833	12	Blaauw	Blaauw	NNP
cord-262445-54ng7m92	833	13	c	c	NN
cord-262445-54ng7m92	833	14	,	,	,
cord-262445-54ng7m92	833	15	Graziano	Graziano	NNP
cord-262445-54ng7m92	833	16	Pesole	Pesole	NNP
cord-262445-54ng7m92	833	17	b	b	NNP
cord-262445-54ng7m92	833	18	,	,	,
cord-262445-54ng7m92	833	19	Giuseppe	Giuseppe	NNP
cord-262445-54ng7m92	833	20	D'Antona	D'Antona	NNP
cord-262445-54ng7m92	833	21	d	d	XX
cord-262445-54ng7m92	833	22	,	,	,
cord-262445-54ng7m92	833	23	Rossella	Rossella	NNP
cord-262445-54ng7m92	833	24	Tupler	Tupler	NNP
cord-262445-54ng7m92	833	25	a	a	DT
cord-262445-54ng7m92	833	26	.	.	.
cord-262445-54ng7m92	834	1	a	a	DT
cord-262445-54ng7m92	834	2	School	School	NNP
cord-262445-54ng7m92	834	3	of	of	IN
cord-262445-54ng7m92	834	4	Public	Public	NNP
cord-262445-54ng7m92	834	5	Health	Health	NNP
cord-262445-54ng7m92	834	6	Physiotherapy	Physiotherapy	NNP
cord-262445-54ng7m92	834	7	and	and	CC
cord-262445-54ng7m92	834	8	Sports	Sports	NNPS
cord-262445-54ng7m92	834	9	Science	Science	NNP
cord-262445-54ng7m92	834	10	T1DM	T1DM	NNP
cord-262445-54ng7m92	834	11	patients	patient	NNS
cord-262445-54ng7m92	834	12	tend	tend	VBP
cord-262445-54ng7m92	834	13	to	to	TO
cord-262445-54ng7m92	834	14	avoid	avoid	VB
cord-262445-54ng7m92	834	15	exercise	exercise	NN
cord-262445-54ng7m92	834	16	to	to	TO
cord-262445-54ng7m92	834	17	reduce	reduce	VB
cord-262445-54ng7m92	834	18	the	the	DT
cord-262445-54ng7m92	834	19	risk	risk	NN
cord-262445-54ng7m92	834	20	of	of	IN
cord-262445-54ng7m92	834	21	hypoglycaemia	hypoglycaemia	NN
cord-262445-54ng7m92	834	22	[	[	-LRB-
cord-262445-54ng7m92	834	23	2	2	CD
cord-262445-54ng7m92	834	24	]	]	-RRB-
cord-262445-54ng7m92	834	25	and	and	CC
cord-262445-54ng7m92	834	26	losing	lose	VBG
cord-262445-54ng7m92	834	27	the	the	DT
cord-262445-54ng7m92	834	28	beneficial	beneficial	JJ
cord-262445-54ng7m92	834	29	effects	effect	NNS
cord-262445-54ng7m92	834	30	of	of	IN
cord-262445-54ng7m92	834	31	exercise	exercise	NN
cord-262445-54ng7m92	834	32	.	.	.
cord-262445-54ng7m92	835	1	Furthermore	furthermore	RB
cord-262445-54ng7m92	835	2	,	,	,
cord-262445-54ng7m92	835	3	T1DM	T1DM	NNP
cord-262445-54ng7m92	835	4	patients	patient	NNS
cord-262445-54ng7m92	835	5	show	show	VBP
cord-262445-54ng7m92	835	6	an	an	DT
cord-262445-54ng7m92	835	7	impairment	impairment	NN
cord-262445-54ng7m92	835	8	of	of	IN
cord-262445-54ng7m92	835	9	the	the	DT
cord-262445-54ng7m92	835	10	skeletal	skeletal	JJ
cord-262445-54ng7m92	835	11	muscle	muscle	NN
cord-262445-54ng7m92	835	12	growth	growth	NN
cord-262445-54ng7m92	835	13	,	,	,
cord-262445-54ng7m92	835	14	energy	energy	NN
cord-262445-54ng7m92	835	15	metabolism	metabolism	NN
cord-262445-54ng7m92	835	16	and	and	CC
cord-262445-54ng7m92	835	17	repair	repair	NN
cord-262445-54ng7m92	835	18	mechanisms	mechanism	NNS
cord-262445-54ng7m92	835	19	Interstitial	interstitial	JJ
cord-262445-54ng7m92	835	20	glucose	glucose	NN
cord-262445-54ng7m92	835	21	(	(	-LRB-
cord-262445-54ng7m92	835	22	IG	IG	NNP
cord-262445-54ng7m92	835	23	)	)	-RRB-
cord-262445-54ng7m92	835	24	was	be	VBD
cord-262445-54ng7m92	835	25	measured	measure	VBN
cord-262445-54ng7m92	835	26	with	with	IN
cord-262445-54ng7m92	835	27	a	a	DT
cord-262445-54ng7m92	835	28	flash	flash	NN
cord-262445-54ng7m92	835	29	glucose	glucose	NN
cord-262445-54ng7m92	835	30	monitoring	monitoring	NN
cord-262445-54ng7m92	835	31	(	(	-LRB-
cord-262445-54ng7m92	835	32	FGM	FGM	NNP
cord-262445-54ng7m92	835	33	,	,	,
cord-262445-54ng7m92	835	34	Abbott	Abbott	NNP
cord-262445-54ng7m92	835	35	FreeStyle	FreeStyle	NNP
cord-262445-54ng7m92	835	36	Libre	Libre	NNP
cord-262445-54ng7m92	835	37	)	)	-RRB-
cord-262445-54ng7m92	835	38	for	for	IN
cord-262445-54ng7m92	835	39	24-hr	24-hr	JJ
cord-262445-54ng7m92	835	40	pre	pre	NN
cord-262445-54ng7m92	835	41	and	and	CC
cord-262445-54ng7m92	835	42	post	post	JJ
cord-262445-54ng7m92	835	43	exercise	exercise	NN
cord-262445-54ng7m92	835	44	.	.	.
cord-262445-54ng7m92	836	1	The	the	DT
cord-262445-54ng7m92	836	2	mean	mean	JJ
cord-262445-54ng7m92	836	3	amplitude	amplitude	NN
cord-262445-54ng7m92	836	4	of	of	IN
cord-262445-54ng7m92	836	5	glycaemic	glycaemic	JJ
cord-262445-54ng7m92	836	6	excursions	excursion	NNS
cord-262445-54ng7m92	836	7	(	(	-LRB-
cord-262445-54ng7m92	836	8	MAGE	MAGE	NNP
cord-262445-54ng7m92	836	9	)	)	-RRB-
cord-262445-54ng7m92	836	10	,	,	,
cord-262445-54ng7m92	836	11	standard	standard	JJ
cord-262445-54ng7m92	836	12	deviation	deviation	NN
cord-262445-54ng7m92	836	13	(	(	-LRB-
cord-262445-54ng7m92	836	14	SD	sd	NN
cord-262445-54ng7m92	836	15	)	)	-RRB-
cord-262445-54ng7m92	836	16	and	and	CC
cord-262445-54ng7m92	836	17	coefficient	coefficient	NN
cord-262445-54ng7m92	836	18	variation	variation	NN
cord-262445-54ng7m92	836	19	(	(	-LRB-
cord-262445-54ng7m92	836	20	CV	cv	NN
cord-262445-54ng7m92	836	21	)	)	-RRB-
cord-262445-54ng7m92	836	22	of	of	IN
cord-262445-54ng7m92	836	23	IG	IG	NNP
cord-262445-54ng7m92	836	24	were	be	VBD
cord-262445-54ng7m92	836	25	calculated	calculate	VBN
cord-262445-54ng7m92	836	26	from	from	IN
cord-262445-54ng7m92	836	27	FGM	FGM	NNP
cord-262445-54ng7m92	836	28	data	datum	NNS
cord-262445-54ng7m92	836	29	.	.	.
cord-262445-54ng7m92	837	1	Muscle	muscle	NN
cord-262445-54ng7m92	837	2	biopsies	biopsy	NNS
cord-262445-54ng7m92	837	3	were	be	VBD
cord-262445-54ng7m92	837	4	collected	collect	VBN
cord-262445-54ng7m92	837	5	immediately	immediately	RB
cord-262445-54ng7m92	837	6	before	before	IN
cord-262445-54ng7m92	837	7	and	and	CC
cord-262445-54ng7m92	837	8	after	after	IN
cord-262445-54ng7m92	837	9	each	each	DT
cord-262445-54ng7m92	837	10	session	session	NN
cord-262445-54ng7m92	837	11	.	.	.
cord-262445-54ng7m92	838	1	Myogenesis-(Myogenin	Myogenesis-(Myogenin	NNP
cord-262445-54ng7m92	838	2	,	,	,
cord-262445-54ng7m92	838	3	MyoD	MyoD	NNP
cord-262445-54ng7m92	838	4	,	,	,
cord-262445-54ng7m92	838	5	Mrf4	Mrf4	NNP
cord-262445-54ng7m92	838	6	,	,	,
cord-262445-54ng7m92	838	7	Myf5	Myf5	NNP
cord-262445-54ng7m92	838	8	)	)	-RRB-
cord-262445-54ng7m92	838	9	,	,	,
cord-262445-54ng7m92	838	10	inflammation-(IL-6	inflammation-(IL-6	NNP
cord-262445-54ng7m92	838	11	,	,	,
cord-262445-54ng7m92	838	12	TNFα	TNFα	NNP
cord-262445-54ng7m92	838	13	,	,	,
cord-262445-54ng7m92	838	14	MCP1	MCP1	NNP
cord-262445-54ng7m92	838	15	)	)	-RRB-
cord-262445-54ng7m92	838	16	,	,	,
cord-262445-54ng7m92	838	17	oxidative	oxidative	JJ
cord-262445-54ng7m92	838	18	capacity	capacity	NN
cord-262445-54ng7m92	838	19	/	/	SYM
cord-262445-54ng7m92	838	20	metabolism-(PGC-1α1	metabolism-(PGC-1α1	NNPS
cord-262445-54ng7m92	838	21	,	,	,
cord-262445-54ng7m92	838	22	PGC-1α4	PGC-1α4	NNP
cord-262445-54ng7m92	838	23	,	,	,
cord-262445-54ng7m92	838	24	GLUT-4	GLUT-4	NNP
cord-262445-54ng7m92	838	25	)	)	-RRB-
cord-262445-54ng7m92	838	26	and	and	CC
cord-262445-54ng7m92	838	27	muscle	muscle	NN
cord-262445-54ng7m92	838	28	growth	growth	NN
cord-262445-54ng7m92	838	29	-	-	HYPH
cord-262445-54ng7m92	838	30	related	relate	VBN
cord-262445-54ng7m92	838	31	genes	gene	NNS
cord-262445-54ng7m92	838	32	(	(	-LRB-
cord-262445-54ng7m92	838	33	IGF-1	IGF-1	NNP
cord-262445-54ng7m92	838	34	isoforms	isoform	NNS
cord-262445-54ng7m92	838	35	)	)	-RRB-
cord-262445-54ng7m92	838	36	were	be	VBD
cord-262445-54ng7m92	838	37	quantified	quantify	VBN
cord-262445-54ng7m92	838	38	by	by	IN
cord-262445-54ng7m92	838	39	real	real	JJ
cord-262445-54ng7m92	838	40	-	-	HYPH
cord-262445-54ng7m92	838	41	time	time	NN
cord-262445-54ng7m92	838	42	PCR	PCR	NNP
cord-262445-54ng7m92	838	43	.	.	.
cord-262445-54ng7m92	839	1	The	the	DT
cord-262445-54ng7m92	839	2	exercise	exercise	NN
cord-262445-54ng7m92	839	3	-	-	HYPH
cord-262445-54ng7m92	839	4	induced	induce	VBN
cord-262445-54ng7m92	839	5	skeletal	skeletal	JJ
cord-262445-54ng7m92	839	6	muscle	muscle	NN
cord-262445-54ng7m92	839	7	signalling	signal	VBG
cord-262445-54ng7m92	839	8	pathways	pathway	NNS
cord-262445-54ng7m92	839	9	(	(	-LRB-
cord-262445-54ng7m92	839	10	phosphorylation	phosphorylation	NN
cord-262445-54ng7m92	839	11	of	of	IN
cord-262445-54ng7m92	839	12	Akt	Akt	NNP
cord-262445-54ng7m92	839	13	,	,	,
cord-262445-54ng7m92	839	14	p38	p38	CD
cord-262445-54ng7m92	839	15	,	,	,
cord-262445-54ng7m92	839	16	ERK1/2	ERK1/2	NNP
cord-262445-54ng7m92	839	17	,	,	,
cord-262445-54ng7m92	839	18	eEF2	eEF2	NNP
cord-262445-54ng7m92	839	19	,	,	,
cord-262445-54ng7m92	839	20	AMPK	AMPK	NNP
cord-262445-54ng7m92	839	21	)	)	-RRB-
cord-262445-54ng7m92	839	22	were	be	VBD
cord-262445-54ng7m92	839	23	quantified	quantify	VBN
cord-262445-54ng7m92	839	24	by	by	IN
cord-262445-54ng7m92	839	25	western	western	JJ
cord-262445-54ng7m92	839	26	blot	blot	NN
cord-262445-54ng7m92	839	27	.	.	.
cord-262445-54ng7m92	840	1	MAGE	MAGE	NNP
cord-262445-54ng7m92	840	2	,	,	,
cord-262445-54ng7m92	840	3	SD	SD	NNP
cord-262445-54ng7m92	840	4	and	and	CC
cord-262445-54ng7m92	840	5	CV	CV	NNP
cord-262445-54ng7m92	840	6	decreased	decrease	VBD
cord-262445-54ng7m92	840	7	24-hr	24-hr	JJ
cord-262445-54ng7m92	840	8	post	post	NN
cord-262445-54ng7m92	840	9	COMB	comb	NN
cord-262445-54ng7m92	840	10	.	.	.
cord-262445-54ng7m92	841	1	All	all	DT
cord-262445-54ng7m92	841	2	exercise	exercise	NN
cord-262445-54ng7m92	841	3	sessions	session	NNS
cord-262445-54ng7m92	841	4	reduced	reduce	VBD
cord-262445-54ng7m92	841	5	the	the	DT
cord-262445-54ng7m92	841	6	CV	cv	NN
cord-262445-54ng7m92	841	7	over	over	IN
cord-262445-54ng7m92	841	8	a	a	DT
cord-262445-54ng7m92	841	9	6	6	CD
cord-262445-54ng7m92	841	10	to12-hr	to12-hr	NNP
cord-262445-54ng7m92	841	11	period	period	NN
cord-262445-54ng7m92	841	12	after	after	IN
cord-262445-54ng7m92	841	13	exercise	exercise	NN
cord-262445-54ng7m92	841	14	.	.	.
cord-262445-54ng7m92	842	1	No	no	DT
cord-262445-54ng7m92	842	2	severe	severe	JJ
cord-262445-54ng7m92	842	3	hypoglycaemic	hypoglycaemic	JJ
cord-262445-54ng7m92	842	4	events	event	NNS
cord-262445-54ng7m92	842	5	occurred	occur	VBD
cord-262445-54ng7m92	842	6	.	.	.
cord-262445-54ng7m92	843	1	Both	both	DT
cord-262445-54ng7m92	843	2	RES	res	NN
cord-262445-54ng7m92	843	3	and	and	CC
cord-262445-54ng7m92	843	4	COMB	comb	NN
cord-262445-54ng7m92	843	5	increased	increase	VBD
cord-262445-54ng7m92	843	6	the	the	DT
cord-262445-54ng7m92	843	7	activation	activation	NN
cord-262445-54ng7m92	843	8	of	of	IN
cord-262445-54ng7m92	843	9	the	the	DT
cord-262445-54ng7m92	843	10	IGF-1	IGF-1	NNP
cord-262445-54ng7m92	843	11	/	/	SYM
cord-262445-54ng7m92	843	12	Akt	Akt	NNP
cord-262445-54ng7m92	843	13	/	/	SYM
cord-262445-54ng7m92	843	14	mTOR	mTOR	NNP
cord-262445-54ng7m92	843	15	signalling	signal	VBG
cord-262445-54ng7m92	843	16	pathway	pathway	NN
cord-262445-54ng7m92	843	17	(	(	-LRB-
cord-262445-54ng7m92	843	18	Akt	Akt	NNP
cord-262445-54ng7m92	843	19	and	and	CC
cord-262445-54ng7m92	843	20	p38MAPK	p38MAPK	NNPS
cord-262445-54ng7m92	843	21	phosphorylation	phosphorylation	NN
cord-262445-54ng7m92	843	22	)	)	-RRB-
cord-262445-54ng7m92	843	23	,	,	,
cord-262445-54ng7m92	843	24	while	while	IN
cord-262445-54ng7m92	843	25	eEF2	eEF2	NNP
cord-262445-54ng7m92	843	26	activation	activation	NN
cord-262445-54ng7m92	843	27	(	(	-LRB-
cord-262445-54ng7m92	843	28	dephosphorylation	dephosphorylation	NN
cord-262445-54ng7m92	843	29	)	)	-RRB-
cord-262445-54ng7m92	843	30	and	and	CC
cord-262445-54ng7m92	843	31	gene	gene	NN
cord-262445-54ng7m92	843	32	expression	expression	NN
cord-262445-54ng7m92	843	33	of	of	IN
cord-262445-54ng7m92	843	34	Myogenin	Myogenin	NNP
cord-262445-54ng7m92	843	35	and	and	CC
cord-262445-54ng7m92	843	36	MRF4	MRF4	NNP
cord-262445-54ng7m92	843	37	increased	increase	VBD
cord-262445-54ng7m92	843	38	only	only	RB
cord-262445-54ng7m92	843	39	after	after	IN
cord-262445-54ng7m92	843	40	COMB	comb	NN
cord-262445-54ng7m92	843	41	and	and	CC
cord-262445-54ng7m92	843	42	RES	res	NN
cord-262445-54ng7m92	843	43	.	.	.
cord-262445-54ng7m92	844	1	Both	both	DT
cord-262445-54ng7m92	844	2	AER	AER	NNP
cord-262445-54ng7m92	844	3	and	and	CC
cord-262445-54ng7m92	844	4	COMB	comb	NN
cord-262445-54ng7m92	844	5	promoted	promote	VBD
cord-262445-54ng7m92	844	6	the	the	DT
cord-262445-54ng7m92	844	7	splicing	splicing	NN
cord-262445-54ng7m92	844	8	of	of	IN
cord-262445-54ng7m92	844	9	IGF-1Ea	IGF-1Ea	NNP
cord-262445-54ng7m92	844	10	variant	variant	NN
cord-262445-54ng7m92	844	11	and	and	CC
cord-262445-54ng7m92	844	12	increased	increase	VBD
cord-262445-54ng7m92	844	13	PGC-1α	PGC-1α	NNP
cord-262445-54ng7m92	844	14	isoforms	isoform	NNS
cord-262445-54ng7m92	844	15	expression	expression	NN
cord-262445-54ng7m92	844	16	.	.	.
cord-262445-54ng7m92	845	1	The	the	DT
cord-262445-54ng7m92	845	2	expression	expression	NN
cord-262445-54ng7m92	845	3	of	of	IN
cord-262445-54ng7m92	845	4	inflammation	inflammation	NN
cord-262445-54ng7m92	845	5	-	-	HYPH
cord-262445-54ng7m92	845	6	related	relate	VBN
cord-262445-54ng7m92	845	7	genes	gene	NNS
cord-262445-54ng7m92	845	8	(	(	-LRB-
cord-262445-54ng7m92	845	9	TNF	TNF	NNP
cord-262445-54ng7m92	845	10	-	-	HYPH
cord-262445-54ng7m92	845	11	α	α	NNP
cord-262445-54ng7m92	845	12	,	,	,
cord-262445-54ng7m92	845	13	IL-6	IL-6	NNP
cord-262445-54ng7m92	845	14	and	and	CC
cord-262445-54ng7m92	845	15	MCP-1	MCP-1	NNP
cord-262445-54ng7m92	845	16	)	)	-RRB-
cord-262445-54ng7m92	845	17	increased	increase	VBD
cord-262445-54ng7m92	845	18	after	after	IN
cord-262445-54ng7m92	845	19	all	all	DT
cord-262445-54ng7m92	845	20	exercise	exercise	NN
cord-262445-54ng7m92	845	21	sessions	session	NNS
cord-262445-54ng7m92	845	22	Diabetes	diabetes	NN
cord-262445-54ng7m92	846	1	Care	care	NN
cord-262445-54ng7m92	846	2	Diabetes	diabetes	NN
cord-262445-54ng7m92	847	1	Care	care	VB
cord-262445-54ng7m92	847	2	N6-Methyladenosine	n6-methyladenosine	CC
cord-262445-54ng7m92	847	3	as	as	IN
cord-262445-54ng7m92	847	4	a	a	DT
cord-262445-54ng7m92	847	5	novel	novel	JJ
cord-262445-54ng7m92	847	6	pharmacological	pharmacological	JJ
cord-262445-54ng7m92	847	7	target	target	NN
cord-262445-54ng7m92	847	8	involved	involve	VBN
cord-262445-54ng7m92	847	9	in	in	IN
cord-262445-54ng7m92	847	10	muscle	muscle	NN
cord-262445-54ng7m92	847	11	regeneration	regeneration	NN
cord-262445-54ng7m92	847	12	Costantin	Costantin	NNP
cord-262445-54ng7m92	847	13	Heil	Heil	NNP
cord-262445-54ng7m92	848	1	a	a	LS
cord-262445-54ng7m92	848	2	,	,	,
cord-262445-54ng7m92	848	3	Francesco	Francesco	NNP
cord-262445-54ng7m92	848	4	Millozzi	Millozzi	NNP
cord-262445-54ng7m92	849	1	a	a	LS
cord-262445-54ng7m92	849	2	,	,	,
cord-262445-54ng7m92	849	3	Luca	Luca	NNP
cord-262445-54ng7m92	849	4	Madaro	Madaro	NNP
cord-262445-54ng7m92	849	5	b	b	NNP
cord-262445-54ng7m92	849	6	,	,	,
cord-262445-54ng7m92	849	7	Marco	Marco	NNP
cord-262445-54ng7m92	849	8	De	De	NNP
cord-262445-54ng7m92	849	9	Bardi	Bardi	NNP
cord-262445-54ng7m92	849	10	c	c	NNP
cord-262445-54ng7m92	849	11	,	,	,
cord-262445-54ng7m92	849	12	Daniela	Daniela	NNP
cord-262445-54ng7m92	849	13	Palacios	Palacios	NNP
cord-262445-54ng7m92	850	1	a	a	DT
cord-262445-54ng7m92	850	2	a.	a.	NN
cord-262445-54ng7m92	850	3	Laboratory	Laboratory	NNP
cord-262445-54ng7m92	850	4	of	of	IN
cord-262445-54ng7m92	850	5	Epigenetics	Epigenetics	NNP
cord-262445-54ng7m92	850	6	and	and	CC
cord-262445-54ng7m92	850	7	Signal	Signal	NNP
cord-262445-54ng7m92	850	8	Transduction	Transduction	NNP
cord-262445-54ng7m92	850	9	,	,	,
cord-262445-54ng7m92	850	10	IRCCS	IRCCS	NNP
cord-262445-54ng7m92	850	11	Fondazione	Fondazione	NNP
cord-262445-54ng7m92	850	12	Santa	Santa	NNP
cord-262445-54ng7m92	850	13	Lucia	Lucia	NNP
cord-262445-54ng7m92	850	14	,	,	,
cord-262445-54ng7m92	851	1	Via	via	IN
cord-262445-54ng7m92	852	1	del	del	NNP
cord-262445-54ng7m92	852	2	Fosso	Fosso	NNP
cord-262445-54ng7m92	852	3	di	di	FW
cord-262445-54ng7m92	852	4	Fiorano	Fiorano	NNP
cord-262445-54ng7m92	852	5	Identification	Identification	NNP
cord-262445-54ng7m92	852	6	of	of	IN
cord-262445-54ng7m92	852	7	a	a	DT
cord-262445-54ng7m92	852	8	phytotherapy	phytotherapy	NN
cord-262445-54ng7m92	852	9	formulation	formulation	NN
cord-262445-54ng7m92	852	10	to	to	TO
cord-262445-54ng7m92	852	11	counteract	counteract	VB
cord-262445-54ng7m92	852	12	muscle	muscle	NN
cord-262445-54ng7m92	852	13	atrophy	atrophy	NN
cord-262445-54ng7m92	852	14	Skeletal	skeletal	JJ
cord-262445-54ng7m92	852	15	muscle	muscle	NN
cord-262445-54ng7m92	852	16	atrophy	atrophy	NN
cord-262445-54ng7m92	852	17	is	be	VBZ
cord-262445-54ng7m92	852	18	a	a	DT
cord-262445-54ng7m92	852	19	loss	loss	NN
cord-262445-54ng7m92	852	20	of	of	IN
cord-262445-54ng7m92	852	21	muscle	muscle	NN
cord-262445-54ng7m92	852	22	mass	mass	NN
cord-262445-54ng7m92	852	23	and	and	CC
cord-262445-54ng7m92	852	24	strength	strength	NN
cord-262445-54ng7m92	852	25	associated	associate	VBN
cord-262445-54ng7m92	852	26	with	with	IN
cord-262445-54ng7m92	852	27	several	several	JJ
cord-262445-54ng7m92	852	28	pathologies	pathology	NNS
cord-262445-54ng7m92	852	29	including	include	VBG
cord-262445-54ng7m92	852	30	diseases	disease	NNS
cord-262445-54ng7m92	852	31	characterized	characterize	VBN
cord-262445-54ng7m92	852	32	by	by	IN
cord-262445-54ng7m92	852	33	systemic	systemic	JJ
cord-262445-54ng7m92	852	34	chronic	chronic	JJ
cord-262445-54ng7m92	852	35	inflammation	inflammation	NN
cord-262445-54ng7m92	853	1	The	the	DT
cord-262445-54ng7m92	853	2	increase	increase	NN
cord-262445-54ng7m92	853	3	of	of	IN
cord-262445-54ng7m92	853	4	a	a	DT
cord-262445-54ng7m92	853	5	catabolic	catabolic	JJ
cord-262445-54ng7m92	853	6	state	state	NN
cord-262445-54ng7m92	853	7	resulting	result	VBG
cord-262445-54ng7m92	853	8	in	in	IN
cord-262445-54ng7m92	853	9	the	the	DT
cord-262445-54ng7m92	853	10	breakdown	breakdown	NN
cord-262445-54ng7m92	853	11	of	of	IN
cord-262445-54ng7m92	853	12	myofibrillary	myofibrillary	JJ
cord-262445-54ng7m92	853	13	proteins	protein	NNS
cord-262445-54ng7m92	853	14	,	,	,
cord-262445-54ng7m92	853	15	especially	especially	RB
cord-262445-54ng7m92	853	16	myosin	myosin	NN
cord-262445-54ng7m92	853	17	heavy	heavy	JJ
cord-262445-54ng7m92	853	18	chain	chain	NN
cord-262445-54ng7m92	853	19	(	(	-LRB-
cord-262445-54ng7m92	853	20	MyHC	MyHC	NNP
cord-262445-54ng7m92	853	21	)	)	-RRB-
cord-262445-54ng7m92	853	22	,	,	,
cord-262445-54ng7m92	853	23	is	be	VBZ
cord-262445-54ng7m92	853	24	recognized	recognize	VBN
cord-262445-54ng7m92	853	25	as	as	IN
cord-262445-54ng7m92	853	26	the	the	DT
cord-262445-54ng7m92	853	27	main	main	JJ
cord-262445-54ng7m92	853	28	process	process	NN
cord-262445-54ng7m92	853	29	promoting	promote	VBG
cord-262445-54ng7m92	853	30	muscle	muscle	NN
cord-262445-54ng7m92	853	31	atrophy	atrophy	NN
cord-262445-54ng7m92	853	32	[	[	-LRB-
cord-262445-54ng7m92	853	33	3	3	CD
cord-262445-54ng7m92	853	34	]	]	-RRB-
cord-262445-54ng7m92	853	35	.	.	.
cord-262445-54ng7m92	854	1	Recently	recently	RB
cord-262445-54ng7m92	854	2	,	,	,
cord-262445-54ng7m92	854	3	the	the	DT
cord-262445-54ng7m92	854	4	interest	interest	NN
cord-262445-54ng7m92	854	5	in	in	IN
cord-262445-54ng7m92	854	6	plant	plant	NN
cord-262445-54ng7m92	854	7	extracts	extract	NNS
cord-262445-54ng7m92	854	8	/	/	SYM
cord-262445-54ng7m92	854	9	metabolites	metabolite	NNS
cord-262445-54ng7m92	854	10	active	active	JJ
cord-262445-54ng7m92	854	11	in	in	IN
cord-262445-54ng7m92	854	12	the	the	DT
cord-262445-54ng7m92	854	13	pathophysiology	pathophysiology	NN
cord-262445-54ng7m92	854	14	of	of	IN
cord-262445-54ng7m92	854	15	muscle	muscle	NN
cord-262445-54ng7m92	854	16	is	be	VBZ
cord-262445-54ng7m92	854	17	obtaining	obtain	VBG
cord-262445-54ng7m92	854	18	growing	grow	VBG
cord-262445-54ng7m92	854	19	attention	attention	NN
cord-262445-54ng7m92	854	20	[	[	-LRB-
cord-262445-54ng7m92	854	21	4	4	CD
cord-262445-54ng7m92	854	22	]	]	-RRB-
cord-262445-54ng7m92	854	23	.	.	.
cord-262445-54ng7m92	855	1	Starting	start	VBG
cord-262445-54ng7m92	855	2	from	from	IN
cord-262445-54ng7m92	855	3	one	one	CD
cord-262445-54ng7m92	855	4	hundred	hundred	CD
cord-262445-54ng7m92	855	5	hydroalcoholic	hydroalcoholic	JJ
cord-262445-54ng7m92	855	6	extracts	extract	NNS
cord-262445-54ng7m92	855	7	from	from	IN
cord-262445-54ng7m92	855	8	medical	medical	JJ
cord-262445-54ng7m92	855	9	plants	plant	NNS
cord-262445-54ng7m92	855	10	,	,	,
cord-262445-54ng7m92	855	11	our	-PRON-	PRP$
cord-262445-54ng7m92	855	12	work	work	NN
cord-262445-54ng7m92	855	13	was	be	VBD
cord-262445-54ng7m92	855	14	aimed	aim	VBN
cord-262445-54ng7m92	855	15	to	to	TO
cord-262445-54ng7m92	855	16	individuate	individuate	VB
cord-262445-54ng7m92	855	17	a	a	DT
cord-262445-54ng7m92	855	18	herbal	herbal	JJ
cord-262445-54ng7m92	855	19	formulation	formulation	NN
cord-262445-54ng7m92	855	20	efficient	efficient	JJ
cord-262445-54ng7m92	855	21	in	in	IN
cord-262445-54ng7m92	855	22	counteracting	counteract	VBG
cord-262445-54ng7m92	855	23	muscle	muscle	NN
cord-262445-54ng7m92	855	24	atrophy	atrophy	NN
cord-262445-54ng7m92	855	25	.	.	.
cord-262445-54ng7m92	856	1	By	by	IN
cord-262445-54ng7m92	856	2	using	use	VBG
cord-262445-54ng7m92	856	3	well	well	RB
cord-262445-54ng7m92	856	4	-	-	HYPH
cord-262445-54ng7m92	856	5	characterized	characterize	VBN
cord-262445-54ng7m92	856	6	in	in	IN
cord-262445-54ng7m92	856	7	vitro	vitro	FW
cord-262445-54ng7m92	856	8	experimental	experimental	JJ
cord-262445-54ng7m92	856	9	models	model	NNS
cord-262445-54ng7m92	856	10	mimicking	mimic	VBG
cord-262445-54ng7m92	856	11	muscle	muscle	NN
cord-262445-54ng7m92	856	12	atrophy	atrophy	NN
cord-262445-54ng7m92	856	13	,	,	,
cord-262445-54ng7m92	856	14	i.e.	i.e.	FW
cord-262445-54ng7m92	856	15	,	,	,
cord-262445-54ng7m92	856	16	treatment	treatment	NN
cord-262445-54ng7m92	856	17	of	of	IN
cord-262445-54ng7m92	856	18	myotubes	myotube	NNS
cord-262445-54ng7m92	856	19	from	from	IN
cord-262445-54ng7m92	856	20	C2C12	c2c12	JJ
cord-262445-54ng7m92	856	21	myoblasts	myoblast	NNS
cord-262445-54ng7m92	856	22	with	with	IN
cord-262445-54ng7m92	856	23	proinflammatory	proinflammatory	JJ
cord-262445-54ng7m92	856	24	cytokines	cytokine	NNS
cord-262445-54ng7m92	856	25	(	(	-LRB-
cord-262445-54ng7m92	856	26	TNFα	TNFα	NNS
cord-262445-54ng7m92	856	27	/	/	SYM
cord-262445-54ng7m92	856	28	IFNγ	IFNγ	NNS
cord-262445-54ng7m92	856	29	)	)	-RRB-
cord-262445-54ng7m92	856	30	or	or	CC
cord-262445-54ng7m92	856	31	excess	excess	JJ
cord-262445-54ng7m92	856	32	GCs	gc	NNS
cord-262445-54ng7m92	856	33	(	(	-LRB-
cord-262445-54ng7m92	856	34	dexamethasone	dexamethasone	NN
cord-262445-54ng7m92	856	35	)	)	-RRB-
cord-262445-54ng7m92	857	1	[	[	-LRB-
cord-262445-54ng7m92	857	2	3	3	CD
cord-262445-54ng7m92	857	3	]	]	-RRB-
cord-262445-54ng7m92	857	4	,	,	,
cord-262445-54ng7m92	857	5	we	-PRON-	PRP
cord-262445-54ng7m92	857	6	firstly	firstly	RB
cord-262445-54ng7m92	857	7	identified	identify	VBD
cord-262445-54ng7m92	857	8	fifteen	fifteen	CD
cord-262445-54ng7m92	857	9	extracts	extract	NNS
cord-262445-54ng7m92	857	10	able	able	JJ
cord-262445-54ng7m92	857	11	to	to	TO
cord-262445-54ng7m92	857	12	rescue	rescue	VB
cord-262445-54ng7m92	857	13	myotube	myotube	NN
cord-262445-54ng7m92	857	14	atrophy	atrophy	NN
cord-262445-54ng7m92	857	15	,	,	,
cord-262445-54ng7m92	857	16	by	by	IN
cord-262445-54ng7m92	857	17	morphological	morphological	JJ
cord-262445-54ng7m92	857	18	analysis	analysis	NN
cord-262445-54ng7m92	857	19	after	after	IN
cord-262445-54ng7m92	857	20	May	May	NNP
cord-262445-54ng7m92	857	21	-	-	HYPH
cord-262445-54ng7m92	857	22	Grunwald	Grunwald	NNP
cord-262445-54ng7m92	857	23	/	/	SYM
cord-262445-54ng7m92	857	24	Giemsa	Giemsa	NNP
cord-262445-54ng7m92	857	25	staining	stain	VBG
cord-262445-54ng7m92	857	26	.	.	.
cord-262445-54ng7m92	858	1	Ten	ten	CD
cord-262445-54ng7m92	858	2	extracts	extract	NNS
cord-262445-54ng7m92	858	3	displayed	display	VBD
cord-262445-54ng7m92	858	4	an	an	DT
cord-262445-54ng7m92	858	5	extremely	extremely	RB
cord-262445-54ng7m92	858	6	potent	potent	JJ
cord-262445-54ng7m92	858	7	protective	protective	JJ
cord-262445-54ng7m92	858	8	effect	effect	NN
cord-262445-54ng7m92	858	9	against	against	IN
cord-262445-54ng7m92	858	10	myotube	myotube	NN
cord-262445-54ng7m92	858	11	atrophy	atrophy	NN
cord-262445-54ng7m92	858	12	and	and	CC
cord-262445-54ng7m92	858	13	MyHC	myhc	NN
cord-262445-54ng7m92	858	14	degradation	degradation	NN
cord-262445-54ng7m92	858	15	,	,	,
cord-262445-54ng7m92	858	16	as	as	IN
cord-262445-54ng7m92	858	17	indicated	indicate	VBN
cord-262445-54ng7m92	858	18	by	by	IN
cord-262445-54ng7m92	858	19	measurement	measurement	NN
cord-262445-54ng7m92	858	20	of	of	IN
cord-262445-54ng7m92	858	21	myotube	myotube	NN
cord-262445-54ng7m92	858	22	diameters	diameter	NNS
cord-262445-54ng7m92	858	23	after	after	IN
cord-262445-54ng7m92	858	24	immunofluorescence	immunofluorescence	NN
cord-262445-54ng7m92	858	25	staining	staining	NN
cord-262445-54ng7m92	858	26	for	for	IN
cord-262445-54ng7m92	858	27	MyHC	MyHC	NNP
cord-262445-54ng7m92	858	28	-	-	HYPH
cord-262445-54ng7m92	858	29	IIa	IIa	NNP
cord-262445-54ng7m92	858	30	,	,	,
cord-262445-54ng7m92	858	31	even	even	RB
cord-262445-54ng7m92	858	32	if	if	IN
cord-262445-54ng7m92	858	33	at	at	IN
cord-262445-54ng7m92	858	34	different	different	JJ
cord-262445-54ng7m92	858	35	extent	extent	NN
cord-262445-54ng7m92	858	36	in	in	IN
cord-262445-54ng7m92	858	37	the	the	DT
cord-262445-54ng7m92	858	38	presence	presence	NN
cord-262445-54ng7m92	858	39	of	of	IN
cord-262445-54ng7m92	858	40	cytokines	cytokine	NNS
cord-262445-54ng7m92	858	41	or	or	CC
cord-262445-54ng7m92	858	42	dexamethasone	dexamethasone	NN
cord-262445-54ng7m92	858	43	.	.	.
cord-262445-54ng7m92	859	1	Based	base	VBN
cord-262445-54ng7m92	859	2	on	on	IN
cord-262445-54ng7m92	859	3	their	-PRON-	PRP$
cord-262445-54ng7m92	859	4	anti	anti	JJ
cord-262445-54ng7m92	859	5	-	-	JJ
cord-262445-54ng7m92	859	6	atrophic	atrophic	JJ
cord-262445-54ng7m92	859	7	potential	potential	NN
cord-262445-54ng7m92	859	8	and	and	CC
cord-262445-54ng7m92	859	9	NMR	nmr	NN
cord-262445-54ng7m92	859	10	-	-	HYPH
cord-262445-54ng7m92	859	11	based	base	VBN
cord-262445-54ng7m92	859	12	metabolic	metabolic	JJ
cord-262445-54ng7m92	859	13	profiles	profile	NNS
cord-262445-54ng7m92	859	14	,	,	,
cord-262445-54ng7m92	859	15	we	-PRON-	PRP
cord-262445-54ng7m92	859	16	selected	select	VBD
cord-262445-54ng7m92	859	17	six	six	CD
cord-262445-54ng7m92	859	18	extracts	extract	NNS
cord-262445-54ng7m92	859	19	(	(	-LRB-
cord-262445-54ng7m92	860	1	Withania	Withania	NNP
cord-262445-54ng7m92	860	2	somnifera	somnifera	VBP
cord-262445-54ng7m92	860	3	Dunal	Dunal	NNP
cord-262445-54ng7m92	860	4	,	,	,
cord-262445-54ng7m92	860	5	Panax	Panax	NNP
cord-262445-54ng7m92	860	6	ginseng	ginseng	NN
cord-262445-54ng7m92	860	7	Meyer	Meyer	NNP
cord-262445-54ng7m92	860	8	,	,	,
cord-262445-54ng7m92	860	9	Silybum	Silybum	NNP
cord-262445-54ng7m92	860	10	marianum	marianum	NNP
cord-262445-54ng7m92	860	11	Gaertner	Gaertner	NNP
cord-262445-54ng7m92	860	12	,	,	,
cord-262445-54ng7m92	860	13	Peumus	Peumus	NNP
cord-262445-54ng7m92	860	14	boldus	boldus	NNP
cord-262445-54ng7m92	860	15	Molina	Molina	NNP
cord-262445-54ng7m92	860	16	,	,	,
cord-262445-54ng7m92	860	17	Trigonella	Trigonella	NNP
cord-262445-54ng7m92	860	18	foenum	foenum	NNP
cord-262445-54ng7m92	860	19	-	-	HYPH
cord-262445-54ng7m92	860	20	graecum	graecum	NNP
cord-262445-54ng7m92	860	21	L.	L.	NNP
cord-262445-54ng7m92	860	22	and	and	CC
cord-262445-54ng7m92	860	23	Urtica	Urtica	NNP
cord-262445-54ng7m92	860	24	dioica	dioica	NNP
cord-262445-54ng7m92	860	25	L.	L.	NNP
cord-262445-54ng7m92	860	26	)	)	-RRB-
cord-262445-54ng7m92	860	27	to	to	TO
cord-262445-54ng7m92	860	28	obtain	obtain	VB
cord-262445-54ng7m92	860	29	twenty	twenty	CD
cord-262445-54ng7m92	860	30	combinations	combination	NNS
cord-262445-54ng7m92	860	31	of	of	IN
cord-262445-54ng7m92	860	32	three	three	CD
cord-262445-54ng7m92	860	33	extracts	extract	NNS
cord-262445-54ng7m92	860	34	to	to	TO
cord-262445-54ng7m92	860	35	test	test	VB
cord-262445-54ng7m92	860	36	on	on	IN
cord-262445-54ng7m92	860	37	myotube	myotube	NN
cord-262445-54ng7m92	860	38	cultures	culture	NNS
cord-262445-54ng7m92	860	39	.	.	.
cord-262445-54ng7m92	861	1	Three	three	CD
cord-262445-54ng7m92	861	2	herbal	herbal	JJ
cord-262445-54ng7m92	861	3	formulations	formulation	NNS
cord-262445-54ng7m92	861	4	showed	show	VBD
cord-262445-54ng7m92	861	5	a	a	DT
cord-262445-54ng7m92	861	6	surprising	surprising	JJ
cord-262445-54ng7m92	861	7	ability	ability	NN
cord-262445-54ng7m92	861	8	to	to	TO
cord-262445-54ng7m92	861	9	counter	counter	VB
cord-262445-54ng7m92	861	10	the	the	DT
cord-262445-54ng7m92	861	11	reduction	reduction	NN
cord-262445-54ng7m92	861	12	of	of	IN
cord-262445-54ng7m92	861	13	myotube	myotube	NN
cord-262445-54ng7m92	861	14	diameters	diameter	NNS
cord-262445-54ng7m92	861	15	and	and	CC
cord-262445-54ng7m92	861	16	degradation	degradation	NN
cord-262445-54ng7m92	861	17	of	of	IN
cord-262445-54ng7m92	861	18	MyHC	myhc	NN
cord-262445-54ng7m92	861	19	in	in	IN
cord-262445-54ng7m92	861	20	the	the	DT
cord-262445-54ng7m92	861	21	presence	presence	NN
cord-262445-54ng7m92	861	22	of	of	IN
cord-262445-54ng7m92	861	23	different	different	JJ
cord-262445-54ng7m92	861	24	atrophic	atrophic	JJ
cord-262445-54ng7m92	861	25	stimuli	stimulus	NNS
cord-262445-54ng7m92	862	1	The	the	DT
cord-262445-54ng7m92	862	2	emerging	emerge	VBG
cord-262445-54ng7m92	862	3	awareness	awareness	NN
cord-262445-54ng7m92	862	4	that	that	IN
cord-262445-54ng7m92	862	5	cell	cell	NN
cord-262445-54ng7m92	862	6	populations	population	NNS
cord-262445-54ng7m92	862	7	are	be	VBP
cord-262445-54ng7m92	862	8	heterogeneous	heterogeneous	JJ
cord-262445-54ng7m92	862	9	has	have	VBZ
cord-262445-54ng7m92	862	10	changed	change	VBN
cord-262445-54ng7m92	862	11	our	-PRON-	PRP$
cord-262445-54ng7m92	862	12	criteria	criterion	NNS
cord-262445-54ng7m92	862	13	to	to	TO
cord-262445-54ng7m92	862	14	define	define	VB
cord-262445-54ng7m92	862	15	a	a	DT
cord-262445-54ng7m92	862	16	cell	cell	NN
cord-262445-54ng7m92	862	17	type	type	NN
cord-262445-54ng7m92	862	18	.	.	.
cord-262445-54ng7m92	863	1	Among	among	IN
cord-262445-54ng7m92	863	2	the	the	DT
cord-262445-54ng7m92	863	3	non	non	JJ
cord-262445-54ng7m92	863	4	-	-	JJ
cord-262445-54ng7m92	863	5	genetic	genetic	JJ
cord-262445-54ng7m92	863	6	sources	source	NNS
cord-262445-54ng7m92	863	7	of	of	IN
cord-262445-54ng7m92	863	8	cell	cell	NN
cord-262445-54ng7m92	863	9	to	to	IN
cord-262445-54ng7m92	863	10	cell	cell	NN
cord-262445-54ng7m92	863	11	variability	variability	NN
cord-262445-54ng7m92	863	12	,	,	,
cord-262445-54ng7m92	863	13	a	a	DT
cord-262445-54ng7m92	863	14	spread	spread	NN
cord-262445-54ng7m92	863	15	in	in	IN
cord-262445-54ng7m92	863	16	a	a	DT
cord-262445-54ng7m92	863	17	bell	bell	NN
cord-262445-54ng7m92	863	18	-	-	HYPH
cord-262445-54ng7m92	863	19	shaped	shape	VBN
cord-262445-54ng7m92	863	20	distribution	distribution	NN
cord-262445-54ng7m92	863	21	of	of	IN
cord-262445-54ng7m92	863	22	a	a	DT
cord-262445-54ng7m92	863	23	feature	feature	NN
cord-262445-54ng7m92	863	24	defines	define	VBZ
cord-262445-54ng7m92	863	25	a	a	DT
cord-262445-54ng7m92	863	26	condition	condition	NN
cord-262445-54ng7m92	863	27	called	call	VBN
cord-262445-54ng7m92	863	28	micro	micro	NN
cord-262445-54ng7m92	863	29	-	-	HYPH
cord-262445-54ng7m92	863	30	heterogeneity	heterogeneity	NN
cord-262445-54ng7m92	863	31	.	.	.
cord-262445-54ng7m92	864	1	The	the	DT
cord-262445-54ng7m92	864	2	effect	effect	NN
cord-262445-54ng7m92	864	3	at	at	IN
cord-262445-54ng7m92	864	4	cellular	cellular	JJ
cord-262445-54ng7m92	864	5	and	and	CC
cord-262445-54ng7m92	864	6	physiological	physiological	JJ
cord-262445-54ng7m92	864	7	level	level	NN
cord-262445-54ng7m92	864	8	of	of	IN
cord-262445-54ng7m92	864	9	this	this	DT
cord-262445-54ng7m92	864	10	type	type	NN
cord-262445-54ng7m92	864	11	of	of	IN
cord-262445-54ng7m92	864	12	heterogeneity	heterogeneity	NN
cord-262445-54ng7m92	864	13	remains	remain	VBZ
cord-262445-54ng7m92	864	14	to	to	TO
cord-262445-54ng7m92	864	15	be	be	VB
cord-262445-54ng7m92	864	16	investigated	investigate	VBN
cord-262445-54ng7m92	864	17	.	.	.
cord-262445-54ng7m92	865	1	We	-PRON-	PRP
cord-262445-54ng7m92	865	2	chose	choose	VBD
cord-262445-54ng7m92	865	3	skeletal	skeletal	JJ
cord-262445-54ng7m92	865	4	muscle	muscle	NN
cord-262445-54ng7m92	865	5	regeneration	regeneration	NN
cord-262445-54ng7m92	865	6	and	and	CC
cord-262445-54ng7m92	865	7	fibro	fibro	NN
cord-262445-54ng7m92	865	8	/	/	SYM
cord-262445-54ng7m92	865	9	adipogenic	adipogenic	JJ
cord-262445-54ng7m92	865	10	progenitors	progenitor	NNS
cord-262445-54ng7m92	865	11	(	(	-LRB-
cord-262445-54ng7m92	865	12	FAPs	fap	NNS
cord-262445-54ng7m92	865	13	)	)	-RRB-
cord-262445-54ng7m92	865	14	to	to	TO
cord-262445-54ng7m92	865	15	address	address	VB
cord-262445-54ng7m92	865	16	this	this	DT
cord-262445-54ng7m92	865	17	issue	issue	NN
cord-262445-54ng7m92	865	18	.	.	.
cord-262445-54ng7m92	866	1	FAPs	fap	NNS
cord-262445-54ng7m92	866	2	are	be	VBP
cord-262445-54ng7m92	866	3	a	a	DT
cord-262445-54ng7m92	866	4	population	population	NN
cord-262445-54ng7m92	866	5	of	of	IN
cord-262445-54ng7m92	866	6	mesenchymal	mesenchymal	JJ
cord-262445-54ng7m92	866	7	progenitors	progenitor	NNS
cord-262445-54ng7m92	866	8	that	that	WDT
cord-262445-54ng7m92	866	9	resides	reside	VBZ
cord-262445-54ng7m92	866	10	in	in	IN
cord-262445-54ng7m92	866	11	the	the	DT
cord-262445-54ng7m92	866	12	interstitium	interstitium	NN
cord-262445-54ng7m92	866	13	of	of	IN
cord-262445-54ng7m92	866	14	skeletal	skeletal	JJ
cord-262445-54ng7m92	866	15	muscle	muscle	NN
cord-262445-54ng7m92	866	16	and	and	CC
cord-262445-54ng7m92	866	17	are	be	VBP
cord-262445-54ng7m92	866	18	identified	identify	VBN
cord-262445-54ng7m92	866	19	by	by	IN
cord-262445-54ng7m92	866	20	the	the	DT
cord-262445-54ng7m92	866	21	expression	expression	NN
cord-262445-54ng7m92	866	22	of	of	IN
cord-262445-54ng7m92	866	23	SCA1	SCA1	NNP
cord-262445-54ng7m92	866	24	.	.	.
cord-262445-54ng7m92	867	1	In	in	IN
cord-262445-54ng7m92	867	2	the	the	DT
cord-262445-54ng7m92	867	3	mdx	mdx	NNP
cord-262445-54ng7m92	867	4	mouse	mouse	NN
cord-262445-54ng7m92	867	5	,	,	,
cord-262445-54ng7m92	867	6	an	an	DT
cord-262445-54ng7m92	867	7	animal	animal	NN
cord-262445-54ng7m92	867	8	model	model	NN
cord-262445-54ng7m92	867	9	of	of	IN
cord-262445-54ng7m92	867	10	Duchenne	Duchenne	NNP
cord-262445-54ng7m92	867	11	Muscular	Muscular	NNP
cord-262445-54ng7m92	867	12	Dystrophy	Dystrophy	NNP
cord-262445-54ng7m92	867	13	(	(	-LRB-
cord-262445-54ng7m92	867	14	DMD	DMD	NNP
cord-262445-54ng7m92	867	15	)	)	-RRB-
cord-262445-54ng7m92	867	16	,	,	,
cord-262445-54ng7m92	867	17	FAPs	fap	NNS
cord-262445-54ng7m92	867	18	are	be	VBP
cord-262445-54ng7m92	867	19	one	one	CD
cord-262445-54ng7m92	867	20	of	of	IN
cord-262445-54ng7m92	867	21	the	the	DT
cord-262445-54ng7m92	867	22	populations	population	NNS
cord-262445-54ng7m92	867	23	responsible	responsible	JJ
cord-262445-54ng7m92	867	24	for	for	IN
cord-262445-54ng7m92	867	25	the	the	DT
cord-262445-54ng7m92	867	26	development	development	NN
cord-262445-54ng7m92	867	27	of	of	IN
cord-262445-54ng7m92	867	28	ectopic	ectopic	JJ
cord-262445-54ng7m92	867	29	tissues	tissue	NNS
cord-262445-54ng7m92	867	30	,	,	,
cord-262445-54ng7m92	867	31	such	such	JJ
cord-262445-54ng7m92	867	32	as	as	IN
cord-262445-54ng7m92	867	33	intramuscular	intramuscular	JJ
cord-262445-54ng7m92	867	34	adipose	adipose	JJ
cord-262445-54ng7m92	867	35	tissue	tissue	NN
cord-262445-54ng7m92	867	36	(	(	-LRB-
cord-262445-54ng7m92	867	37	IMAT	IMAT	NNP
cord-262445-54ng7m92	867	38	)	)	-RRB-
cord-262445-54ng7m92	867	39	and	and	CC
cord-262445-54ng7m92	867	40	fibrotic	fibrotic	JJ
cord-262445-54ng7m92	867	41	tissue	tissue	NN
cord-262445-54ng7m92	867	42	.	.	.
cord-262445-54ng7m92	868	1	Taking	take	VBG
cord-262445-54ng7m92	868	2	advantage	advantage	NN
cord-262445-54ng7m92	868	3	of	of	IN
cord-262445-54ng7m92	868	4	a	a	DT
cord-262445-54ng7m92	868	5	multiplex	multiplex	JJ
cord-262445-54ng7m92	868	6	flow	flow	NN
cord-262445-54ng7m92	868	7	cytometry	cytometry	NN
cord-262445-54ng7m92	868	8	analysis	analysis	NN
cord-262445-54ng7m92	868	9	we	-PRON-	PRP
cord-262445-54ng7m92	868	10	defined	define	VBD
cord-262445-54ng7m92	868	11	two	two	CD
cord-262445-54ng7m92	868	12	FAP	fap	NN
cord-262445-54ng7m92	868	13	cell	cell	NN
cord-262445-54ng7m92	868	14	states	state	NNS
cord-262445-54ng7m92	868	15	characterised	characterise	VBN
cord-262445-54ng7m92	868	16	by	by	IN
cord-262445-54ng7m92	868	17	high	high	JJ
cord-262445-54ng7m92	868	18	and	and	CC
cord-262445-54ng7m92	868	19	low	low	JJ
cord-262445-54ng7m92	868	20	SCA1	SCA1	NNP
cord-262445-54ng7m92	868	21	expression	expression	NN
cord-262445-54ng7m92	868	22	(	(	-LRB-
cord-262445-54ng7m92	868	23	SCA1	SCA1	NNP
cord-262445-54ng7m92	868	24	High	High	NNP
cord-262445-54ng7m92	868	25	and	and	CC
cord-262445-54ng7m92	868	26	SCA1	SCA1	NNP
cord-262445-54ng7m92	868	27	Low	Low	NNP
cord-262445-54ng7m92	868	28	)	)	-RRB-
cord-262445-54ng7m92	868	29	.	.	.
cord-262445-54ng7m92	869	1	These	these	DT
cord-262445-54ng7m92	869	2	two	two	CD
cord-262445-54ng7m92	869	3	sub	sub	NN
cord-262445-54ng7m92	869	4	-	-	NNS
cord-262445-54ng7m92	869	5	populations	population	NNS
cord-262445-54ng7m92	869	6	are	be	VBP
cord-262445-54ng7m92	869	7	differentially	differentially	RB
cord-262445-54ng7m92	869	8	represented	represent	VBN
cord-262445-54ng7m92	869	9	in	in	IN
cord-262445-54ng7m92	869	10	wild	wild	JJ
cord-262445-54ng7m92	869	11	type	type	NN
cord-262445-54ng7m92	869	12	and	and	CC
cord-262445-54ng7m92	869	13	mdx	mdx	NN
cord-262445-54ng7m92	869	14	mouse	mouse	NN
cord-262445-54ng7m92	869	15	.	.	.
cord-262445-54ng7m92	870	1	Next	next	RB
cord-262445-54ng7m92	870	2	,	,	,
cord-262445-54ng7m92	870	3	we	-PRON-	PRP
cord-262445-54ng7m92	870	4	isolated	isolate	VBD
cord-262445-54ng7m92	870	5	the	the	DT
cord-262445-54ng7m92	870	6	two	two	CD
cord-262445-54ng7m92	870	7	FAP	fap	NN
cord-262445-54ng7m92	870	8	sub	sub	NN
cord-262445-54ng7m92	870	9	-	-	NNS
cord-262445-54ng7m92	870	10	populations	population	NNS
cord-262445-54ng7m92	870	11	by	by	IN
cord-262445-54ng7m92	870	12	fluorescence	fluorescence	NN
cord-262445-54ng7m92	870	13	activated	activate	VBN
cord-262445-54ng7m92	870	14	cell	cell	NN
cord-262445-54ng7m92	870	15	sorting	sorting	NN
cord-262445-54ng7m92	870	16	(	(	-LRB-
cord-262445-54ng7m92	870	17	FACS	FACS	NNP
cord-262445-54ng7m92	870	18	)	)	-RRB-
cord-262445-54ng7m92	870	19	from	from	IN
cord-262445-54ng7m92	870	20	mdx	mdx	NNP
cord-262445-54ng7m92	870	21	mouse	mouse	NN
cord-262445-54ng7m92	870	22	and	and	CC
cord-262445-54ng7m92	870	23	we	-PRON-	PRP
cord-262445-54ng7m92	870	24	studied	study	VBD
cord-262445-54ng7m92	870	25	their	-PRON-	PRP$
cord-262445-54ng7m92	870	26	differentiation	differentiation	NN
cord-262445-54ng7m92	870	27	potential	potential	JJ
cord-262445-54ng7m92	870	28	ex	ex	FW
cord-262445-54ng7m92	870	29	vivo	vivo	NN
cord-262445-54ng7m92	870	30	.	.	.
cord-262445-54ng7m92	871	1	We	-PRON-	PRP
cord-262445-54ng7m92	871	2	found	find	VBD
cord-262445-54ng7m92	871	3	that	that	IN
cord-262445-54ng7m92	871	4	SCA1	SCA1	NNP
cord-262445-54ng7m92	871	5	High	High	NNP
cord-262445-54ng7m92	871	6	FAPs	fap	NNS
cord-262445-54ng7m92	871	7	have	have	VBP
cord-262445-54ng7m92	871	8	a	a	DT
cord-262445-54ng7m92	871	9	higher	high	JJR
cord-262445-54ng7m92	871	10	capability	capability	NN
cord-262445-54ng7m92	871	11	to	to	TO
cord-262445-54ng7m92	871	12	express	express	VB
cord-262445-54ng7m92	871	13	PPAR	PPAR	NNP
cord-262445-54ng7m92	871	14	-	-	HYPH
cord-262445-54ng7m92	871	15	gamma	gamma	NN
cord-262445-54ng7m92	871	16	and	and	CC
cord-262445-54ng7m92	871	17	to	to	TO
cord-262445-54ng7m92	871	18	differentiate	differentiate	VB
cord-262445-54ng7m92	871	19	into	into	IN
cord-262445-54ng7m92	871	20	mature	mature	JJ
cord-262445-54ng7m92	871	21	adipocytes	adipocyte	NNS
cord-262445-54ng7m92	871	22	.	.	.
cord-262445-54ng7m92	872	1	Whereas	whereas	IN
cord-262445-54ng7m92	872	2	,	,	,
cord-262445-54ng7m92	872	3	SCA1	SCA1	NNP
cord-262445-54ng7m92	872	4	Low	Low	NNP
cord-262445-54ng7m92	872	5	FAPs	fap	NNS
cord-262445-54ng7m92	872	6	differentiate	differentiate	VBP
cord-262445-54ng7m92	872	7	readily	readily	RB
cord-262445-54ng7m92	872	8	into	into	IN
cord-262445-54ng7m92	872	9	myofibroblasts	myofibroblast	NNS
cord-262445-54ng7m92	872	10	in	in	IN
cord-262445-54ng7m92	872	11	a	a	DT
cord-262445-54ng7m92	872	12	pro	pro	JJ
cord-262445-54ng7m92	872	13	-	-	JJ
cord-262445-54ng7m92	872	14	fibrogenic	fibrogenic	JJ
cord-262445-54ng7m92	872	15	environment	environment	NN
cord-262445-54ng7m92	872	16	.	.	.
cord-262445-54ng7m92	873	1	Moreover	moreover	RB
cord-262445-54ng7m92	873	2	,	,	,
cord-262445-54ng7m92	873	3	SCA1	SCA1	NNP
cord-262445-54ng7m92	873	4	High	High	NNP
cord-262445-54ng7m92	873	5	FAPs	fap	NNS
cord-262445-54ng7m92	873	6	exhibit	exhibit	VBP
cord-262445-54ng7m92	873	7	a	a	DT
cord-262445-54ng7m92	873	8	higher	high	JJR
cord-262445-54ng7m92	873	9	proliferation	proliferation	NN
cord-262445-54ng7m92	873	10	rate	rate	NN
cord-262445-54ng7m92	873	11	than	than	IN
cord-262445-54ng7m92	873	12	SCA1	SCA1	NNP
cord-262445-54ng7m92	873	13	Low	Low	NNP
cord-262445-54ng7m92	873	14	cells	cell	NNS
cord-262445-54ng7m92	873	15	.	.	.
cord-262445-54ng7m92	874	1	Overall	overall	RB
cord-262445-54ng7m92	874	2	,	,	,
cord-262445-54ng7m92	874	3	we	-PRON-	PRP
cord-262445-54ng7m92	874	4	demonstrate	demonstrate	VBP
cord-262445-54ng7m92	874	5	that	that	IN
cord-262445-54ng7m92	874	6	micro	micro	NN
cord-262445-54ng7m92	874	7	-	-	NN
cord-262445-54ng7m92	874	8	heterogeneity	heterogeneity	NN
cord-262445-54ng7m92	874	9	contributes	contribute	VBZ
cord-262445-54ng7m92	874	10	to	to	TO
cord-262445-54ng7m92	874	11	determine	determine	VB
cord-262445-54ng7m92	874	12	the	the	DT
cord-262445-54ng7m92	874	13	fate	fate	NN
cord-262445-54ng7m92	874	14	of	of	IN
cord-262445-54ng7m92	874	15	a	a	DT
cord-262445-54ng7m92	874	16	mesenchymal	mesenchymal	JJ
cord-262445-54ng7m92	874	17	population	population	NN
cord-262445-54ng7m92	874	18	in	in	IN
cord-262445-54ng7m92	874	19	vitro	vitro	FW
cord-262445-54ng7m92	874	20	.	.	.
cord-262445-54ng7m92	875	1	These	these	DT
cord-262445-54ng7m92	875	2	findings	finding	NNS
cord-262445-54ng7m92	875	3	raise	raise	VBP
cord-262445-54ng7m92	875	4	several	several	JJ
cord-262445-54ng7m92	875	5	questions	question	NNS
cord-262445-54ng7m92	875	6	about	about	IN
cord-262445-54ng7m92	875	7	its	-PRON-	PRP$
cord-262445-54ng7m92	875	8	interaction	interaction	NN
cord-262445-54ng7m92	875	9	with	with	IN
cord-262445-54ng7m92	875	10	in	in	IN
cord-262445-54ng7m92	875	11	vivo	vivo	NN
cord-262445-54ng7m92	875	12	microenvironment	microenvironment	NN
cord-262445-54ng7m92	875	13	and	and	CC
cord-262445-54ng7m92	875	14	its	-PRON-	PRP$
cord-262445-54ng7m92	875	15	impact	impact	NN
cord-262445-54ng7m92	875	16	in	in	IN
cord-262445-54ng7m92	875	17	pathology	pathology	NN
cord-262445-54ng7m92	875	18	progression	progression	NN
cord-262445-54ng7m92	875	19	.	.	.
cord-262445-54ng7m92	876	1	Cancer	cancer	NN
cord-262445-54ng7m92	876	2	-	-	HYPH
cord-262445-54ng7m92	876	3	cachexia	cachexia	NN
cord-262445-54ng7m92	876	4	results	result	NNS
cord-262445-54ng7m92	876	5	in	in	IN
cord-262445-54ng7m92	876	6	severe	severe	JJ
cord-262445-54ng7m92	876	7	muscle	muscle	NN
cord-262445-54ng7m92	876	8	tissue	tissue	NN
cord-262445-54ng7m92	876	9	wasting	waste	VBG
cord-262445-54ng7m92	876	10	affecting	affect	VBG
cord-262445-54ng7m92	876	11	patients	patient	NNS
cord-262445-54ng7m92	876	12	'	'	POS
cord-262445-54ng7m92	876	13	quality	quality	NN
cord-262445-54ng7m92	876	14	of	of	IN
cord-262445-54ng7m92	876	15	life	life	NN
cord-262445-54ng7m92	876	16	and	and	CC
cord-262445-54ng7m92	876	17	survival	survival	NN
cord-262445-54ng7m92	876	18	.	.	.
cord-262445-54ng7m92	877	1	Recent	recent	JJ
cord-262445-54ng7m92	877	2	studies	study	NNS
cord-262445-54ng7m92	877	3	showed	show	VBD
cord-262445-54ng7m92	877	4	that	that	IN
cord-262445-54ng7m92	877	5	physical	physical	JJ
cord-262445-54ng7m92	877	6	activity	activity	NN
cord-262445-54ng7m92	877	7	increased	increase	VBN
cord-262445-54ng7m92	877	8	survival	survival	NN
cord-262445-54ng7m92	877	9	in	in	IN
cord-262445-54ng7m92	877	10	cancer	cancer	NN
cord-262445-54ng7m92	877	11	patient	patient	NN
cord-262445-54ng7m92	877	12	and	and	CC
cord-262445-54ng7m92	877	13	animal	animal	NN
cord-262445-54ng7m92	877	14	models	model	NNS
cord-262445-54ng7m92	877	15	.	.	.
cord-262445-54ng7m92	878	1	The	the	DT
cord-262445-54ng7m92	878	2	underlying	underlie	VBG
cord-262445-54ng7m92	878	3	mechanisms	mechanism	NNS
cord-262445-54ng7m92	878	4	,	,	,
cord-262445-54ng7m92	878	5	however	however	RB
cord-262445-54ng7m92	878	6	,	,	,
cord-262445-54ng7m92	878	7	are	be	VBP
cord-262445-54ng7m92	878	8	still	still	RB
cord-262445-54ng7m92	878	9	largely	largely	RB
cord-262445-54ng7m92	878	10	unknown	unknown	JJ
cord-262445-54ng7m92	878	11	.	.	.
cord-262445-54ng7m92	879	1	To	to	TO
cord-262445-54ng7m92	879	2	identify	identify	VB
cord-262445-54ng7m92	879	3	signaling	signal	VBG
cord-262445-54ng7m92	879	4	pathways	pathway	NNS
cord-262445-54ng7m92	879	5	involved	involve	VBN
cord-262445-54ng7m92	879	6	in	in	IN
cord-262445-54ng7m92	879	7	exercisedependent	exercisedependent	NN
cord-262445-54ng7m92	879	8	maintenance	maintenance	NN
cord-262445-54ng7m92	879	9	of	of	IN
cord-262445-54ng7m92	879	10	muscle	muscle	NN
cord-262445-54ng7m92	879	11	mass	mass	NN
cord-262445-54ng7m92	879	12	and	and	CC
cord-262445-54ng7m92	879	13	function	function	VB
cord-262445-54ng7m92	879	14	in	in	IN
cord-262445-54ng7m92	879	15	cachexia	cachexia	NN
cord-262445-54ng7m92	879	16	,	,	,
cord-262445-54ng7m92	879	17	we	-PRON-	PRP
cord-262445-54ng7m92	879	18	investigated	investigate	VBD
cord-262445-54ng7m92	879	19	the	the	DT
cord-262445-54ng7m92	879	20	role	role	NN
cord-262445-54ng7m92	879	21	of	of	IN
cord-262445-54ng7m92	879	22	serum	serum	NN
cord-262445-54ng7m92	879	23	response	response	NN
cord-262445-54ng7m92	879	24	factor	factor	NN
cord-262445-54ng7m92	879	25	(	(	-LRB-
cord-262445-54ng7m92	879	26	SRF	SRF	NNP
cord-262445-54ng7m92	879	27	)	)	-RRB-
cord-262445-54ng7m92	879	28	,	,	,
cord-262445-54ng7m92	879	29	a	a	DT
cord-262445-54ng7m92	879	30	transcription	transcription	NN
cord-262445-54ng7m92	879	31	factor	factor	NN
cord-262445-54ng7m92	879	32	of	of	IN
cord-262445-54ng7m92	879	33	the	the	DT
cord-262445-54ng7m92	879	34	MADS	MADS	NNP
cord-262445-54ng7m92	879	35	-	-	HYPH
cord-262445-54ng7m92	879	36	box	box	NN
cord-262445-54ng7m92	879	37	family	family	NN
cord-262445-54ng7m92	879	38	,	,	,
cord-262445-54ng7m92	879	39	having	have	VBG
cord-262445-54ng7m92	879	40	a	a	DT
cord-262445-54ng7m92	879	41	major	major	JJ
cord-262445-54ng7m92	879	42	role	role	NN
cord-262445-54ng7m92	879	43	in	in	IN
cord-262445-54ng7m92	879	44	muscular	muscular	JJ
cord-262445-54ng7m92	879	45	growth	growth	NN
cord-262445-54ng7m92	879	46	,	,	,
cord-262445-54ng7m92	879	47	differentiation	differentiation	NN
cord-262445-54ng7m92	879	48	and	and	CC
cord-262445-54ng7m92	879	49	regeneration	regeneration	NN
cord-262445-54ng7m92	879	50	.	.	.
cord-262445-54ng7m92	880	1	We	-PRON-	PRP
cord-262445-54ng7m92	880	2	hypothesize	hypothesize	VBP
cord-262445-54ng7m92	880	3	that	that	IN
cord-262445-54ng7m92	880	4	the	the	DT
cord-262445-54ng7m92	880	5	expression	expression	NN
cord-262445-54ng7m92	880	6	and/or	and/or	CC
cord-262445-54ng7m92	880	7	transcriptional	transcriptional	JJ
cord-262445-54ng7m92	880	8	activity	activity	NN
cord-262445-54ng7m92	880	9	of	of	IN
cord-262445-54ng7m92	880	10	SRF	SRF	NNP