id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-267110-2g6owogs	Sharma, Suvasini	Acute Disseminated Encephalomyelitis	2017-11-17		.txt	text/plain	5206	328	38	In patients who have a relapse, biomarkers and imaging should help differentiate multiphasic ADEM, neuromyelitis optica spectrum disorder, anti-MOG antibody–associated relapsing demyelination, and multiple sclerosis. Acute disseminated encephalomyelitis (ADEM) is an acute immune-mediated inflammatory demyelinating condition involving the brain and spinal cord, which presents clinically with new-onset polyfocal neurologic features, which by definition include encephalopathy. A third ADEM-like event is not consistent with a diagnosis of multiphasic ADEM but indicates a chronic relapsing demyelinating disorder, such as relapsing optic neuritis, neuromyelitis optica spectrum disorder associated with antiaquaporin-4 antibodies, relapsing anti-MOG antibody-associated demyelination, or MS depending the clinical phenotype, biomarker, and neuroimaging findings. A long-term follow-up study using the 2007 International Pediatrics Multiple Sclerosis Study Group criteria evaluated the parameters at initial diagnosis and eventual conversion to MS in a cohort of 123 children with a first episode of acute CNS demyelination. Multiple sclerosis and acute disseminated encephalomyelitis diagnosed in children after long-term follow-up: comparison of presenting features An adult case of anti-myelin oligodendrocyte glycoprotein (MOG) antibody-associated multiphasic acute disseminated encephalomyelitis at 33-year intervals	./cache/cord-267110-2g6owogs.txt	./txt/cord-267110-2g6owogs.txt