id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-303292-iheq50ub	De Jong, Audrey	How to ventilate obese patients in the ICU	2020-10-23		.txt	text/plain	7496	355	41	Regarding mechanical ventilation in patients with and without acute respiratory distress syndrome (ARDS), low tidal volume (6 ml/kg of predicted body weight) and moderate to high positive end-expiratory pressure (PEEP), with careful recruitment maneuver in selected patients, are advised. During invasive mechanical ventilation, patients with obesity are more prone to lung collapse and require higher PEEP to avoid it; low V T is calculated on predicted body weight. In a randomized controlled trial of the same team comparing HFNC to standard oxygen [87] in high-risk non-hypercapnic patients including 22% of patients with obesity, the study was stopped due to low recruitment after 155 patients, without any difference in extubation failure rate found between the two groups. PBW predicted body weight, PEEP positive end-expiratory pressure, ARDS acute respiratory distress syndrome, ECMO extracorporeal membrane oxygenation, CPAP continuous positive airway pressure, NIV noninvasive ventilation, HFNC high-flow nasal cannula oxygen patients.	./cache/cord-303292-iheq50ub.txt	./txt/cord-303292-iheq50ub.txt