id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-346565-vsgbmxzv	Cascella, Marco	Rapid and Impressive Response to a Combined Treatment with Single-Dose Tocilizumab and NIV in a Patient with COVID-19 Pneumonia/ARDS	2020-07-27		.txt	text/plain	3855	200	48	Treatment of acute respiratory distress syndrome (ARDS) due to COVID-19 pneumonia (CARDS) represents a clinical challenge, requiring often invasive mechanical ventilation (IMV). Despite that at the beginning of the pandemic, early invasive mechanical ventilation was indicated as the optimal strategy for CARDS management, in COVID-19 pneumonia the clinical picture of severe hypoxemia contrasted with the typical ARDS respiratory mechanics. Clinical experience, for example, suggested that non-invasive ventilation (NIV) has a role of primary importance in the management of CARDS as it can improve oxygenation, limiting the work of the respiratory muscles and preventing the onset of the patient self-inflicted lung injury (P-SILI) [2] . In this setting, adding the prone position to NIV could improve oxygenation, decrease respiratory effort, reducing self-induced lung injury, and avoid the need of intubation and invasive ventilation, which could be particularly useful in the case of reduced availability of intensive care unit (ICU) beds [4] [5] [6] .	./cache/cord-346565-vsgbmxzv.txt	./txt/cord-346565-vsgbmxzv.txt